Exercise in Pregnant Women With Gestational Diabetes

Study Overview
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Brief Summary
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Gestational diabetes (GDM) impacts 1 in 10 pregnancies; hyperglycemia and hypertriglyceridemia are common features of the condition. Women are recommended to do at least 150 minutes of moderate-intensity aerobic activity a week during pregnancy and the postpartum period. Exercise both during and out of pregnancy has been shown to be an effective non-pharmacologic tool to reduce glucose and lipid profiles. The goals and purpose of this pilot study is to 1) determine the influence of exercise and the timing of exercise surrounding a meal on glucose and lipid metabolism in pregnant women with GDM and 2) determine the feasibility of low-resistance and aerobic activity and measuring exercise metrics during pregnancy. The overarching objective of this study is to determine the effects of low-resistance and aerobic exercise on glucose and lipids following a meal in pregnant women with GDM.

Detailed Description
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Gestational diabetes (GDM) impacts 1 in 10 pregnancies; hyperglycemia and hypertriglyceridemia are common features of the condition. Women are recommended to do at least 150 minutes of moderate-intensity aerobic activity a week during pregnancy and the postpartum period. Exercise both during and out of pregnancy has been shown to be an effective non-pharmacologic tool to reduce glucose and lipid profiles. The goals and purpose of this pilot study is to 1) determine the influence of exercise and the timing of exercise surrounding a meal on glucose and lipid metabolism in pregnant women with GDM and 2) determine the feasibility of low-resistance and aerobic activity and measuring exercise metrics during pregnancy. The overarching objective of this study is to determine the effects of low-resistance and aerobic exercise on glucose and lipids following a meal in pregnant women with GDM. Women will perform either low-resistance or aerobic exercise. Blood will be taken before and 2 hours after a fixed meal. For safety, women will have supervised exercise and oxygen consumption will be measured throughout the activity.

Official Title
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Evaluating the Effects of Low-resistance and Aerobic Exercise on Glucose and Lipids in Pregnant Women With Gestational Diabetes

Conditions
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Gestational Diabetes

Intervention / Treatment
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* Behavioral: physical activity


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: diet and lifestyle controlled gestational diabetes Gestational age 28 weeks-32 weeks gestation Age 18-50 years Singleton pregnancy Exclusion Criteria: Chronic hypertension Pregestational diabetes History of peripartum cardiomyopathy Any condition contraindicating for exercise Taking any cardiovascular modifying medications (beta-blockers, calcium channel blockers, corticosteroids) Asthma or other underlying lung disease that is equivalent or worse than persistent mild classification (defined as at least >2 day/week asthmatic symptoms, 1-2x/month nighttime awakenings, >2days/week short-acting beta-agonist use for symptom control, and minor limitations with normal activity; ≥2 exacerbations in 6 months requiring oral systemic corticosteroids, ≥4 wheezing episodes/1 year lasting >1 day) Congenital anomalies Multifetal gestation Current alcohol use Current tobacco use

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Single Group Assignment
Interventional Model Description: all women with diet and lifestyle controlled gestational diabetes. each will serve as their own control
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: low-resistance<br>women will perform low-resistance physical activity | Behavioral: physical activity<br>* exercise<br>|
| Experimental: aerobic<br>women will perform aerobic physical activity | Behavioral: physical activity<br>* exercise<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postprandial glucose | glucose measure after meal following exercise compared to no exercise | 2 hours after meal | 
| postprandial triglyceride | triglyceride measure after meal following exercise compared to no exercise | 2 hours after meal | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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gestational diabetes, pregnancy, exercise