Continuous Versus Interval Walking Training in Patients With COPD - a Pilot Study

Study Overview
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Brief Summary
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This study will investigate the effects of interval walking training versus continuous walking training in patients with chronic obstructive pulmonary disease. Patients will be recruited during a 3-week inpatient pulmonary rehabilitation program and will be randomized to one of the two intervention groups. All walking training sessions will be performed on the same treadmill. Walking intensity in the continuous walking group will be 60 percent of the average speed of the 6-minute walking test. Patients in the interval training group will perform high intensity intervals at 120% of the 6-minute walking test speed for 60 seconds alternating with 60 seconds of rest. The total exercise duration will be progressively increased from 10 to 32 minutes.

Official Title
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Continuous Versus Interval Walking Training in Patients With Severe Chronic Obstructive Pulmonary Disease - a Pilot Study

Conditions
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Chronic Obstructive Airway Disease

Intervention / Treatment
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* Device: Treadmill
* Other: walking training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: COPD stage III or IV according to the Global Initiative for chronic obstructive lung disease [GOLD] stationary patient in the Schön Klinik Berchtesgadener Land Exclusion Criteria: acute, severe exacerbation of COPD failure to comply with study process
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Continuous walking training<br>n=10 patients with COPD Walking intensity 60 percent of 6-minute walking test speed | Device: Treadmill<br> <br> Other: walking training<br> <br> |
| Active Comparator: Interval walking training<br>n=10 patients with COPD Walking intensity 120 percent of 6-minute walking test speed for 1 minute alternating with 1 minute of rest | Device: Treadmill<br> <br> Other: walking training<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| perceived exertion for dyspnea during walking training | measured via modified Borg scale (0 to 10) | day 1 to 21 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| heart rate during walking training |  | day 1 to 21 | 
| perceived exertion for leg fatigue (Borg-scale) |  | during three weeks of rehabilitation | 
| Oxygen saturation during walking training | measured via pulse oximeter | day 1 to 21 | 
| fat free mass in kilogram | measured via Bioimpedance Analysis | day 1 to 21 | 
| forced expiratory volume in 1 second (FEV1) in liter | measured by spirometry | day 1 to 21 | 
| Sit-to-stand-test | 5 repetitions of standing up and sitting down from a chair with crossed arms as quick as possible | day 1 to 21 | 
| 6-minute walking test | the best 6-minute walking test out of two tests on admission and at discharge will be taken | day 1 to 21 | 
| 36 item short-form health Survey (SF-36) | questionnaire for disease unspecific quality of life | day 1 to 21 | 
| chronic respiratory questionnaire (CRQ) | disease specific quality of life questionnaire | day 1 to 21 | 
| hospital anxiety and depression scale (HADS) | questionnaire on symptoms of anxiety and depression | day 1 to 21 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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chronic obstructive pulmonary disease, endurance training, interval training, continuous training, walking training