Desmopressin for Improving Nocturnal Enuresis in Patients After Radical Cystectomy With Bladder Reconstruction

Study Overview
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Brief Summary
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The purpose of this study is to prospectively assess whether Desmopressin, given for a period of month to patients after radical cystectomy with orthotopic bladder reconstruction, improves and lowers the rate of nocturnal enuresis.

Detailed Description
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We will prospectively assess the utilization of Desmopressin in improving nocturnal enuresis in patients after radical cystectomy with orthotopic bladder reconstruction. Patients after radical cystectomy with neobladder reconstruction will be given Desmopressin 0.1 mg once a day for a duration of one month. Before beginning treatment patients will be given the NNES-Q questionnaire to assess severity of nocturnal enuresis. At the end of treatment, the same questionnaire will be given to all patients to assess if nocturnal enuresis improved. Sodium levels will be tested before treatment, 2 weeks after beginning treatment and at the end of treatment.

Official Title
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Usage of Desmopressin fo Improving Nocturnal Enuresis in Patients After Radical Cystectomy With Orthotopic Bladder Reconstruction

Conditions
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Nocturnal Enuresis

Intervention / Treatment
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* Drug: Desmopressin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age above 18 Able to give informed consent Patients afte radical cystectomy with orthotopic bladder reconstruction with night time incontinence Exclusion Criteria: Patients with after radical cystectomy with orthotopic bladder reconstruction with daytime urinary incontinence Patients already treated with Desmopressin due to other reasons. Patients with an allergy or insensitivity to Desmopressin. Patients with known hyponatremia Patients with severe chronic renal failure and creatinine clearance of below 50 cc/sec. Patients with severe congestive heart failure Patients with active urinary tract infection Patients taking drug therapy which can interact with Desmopressin and affect it's action.Examples include Diuretics, Tricyclic antidepressants, Carbamezapine and Chlorpropamide AND Indomethacin. Patients with an indwelling urinary catheter.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Desmopressin<br> | Drug: Desmopressin<br>* Patients after radical cystectomy with orthotopic bladder reconstruction that suffer from night time urinary incontinence will be enrolled in the study. They will be given for a period of one month after informed consent, Desmopressin At a dosage of 0.1 MG per day. The rate of improvement of night time urinary incontinence will be measured.<br>* Other names: Nocturnal Enuresis;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of improvement in Nocturnal incontinence |  | One month |