Cardiac Assessment in Obese and Overweight Children

Study Overview
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Brief Summary
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Is to assess cardiac functions of overweight and obese children attending assiut University children hospital in one year duration .

Detailed Description
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The prevalence of overweight and obesity in children is increasing worldwide at an alarming rate in both developing and developed countries .the relation between obesity and cardiac structure and function in children is less well documented and conflicting results have been reported .In addition, obesity is associated with a heterogeneity of metabolic abnormalities , (e.g., dyslipidemia , insulin resistance hyperglycaemia and hypertension , that may provide a plausible biologic link between obesity and the increased risk of cardiovascular morbidity and mortality .The clustering of these risk factors for cardiovascular disease is referred to as the metabolic syndrome. Although the concept and definition of the metabolic syndrome are controversial at the moment, there is no doubt that a cluster of cardiovascular risk factors is present in obese children and adolescents and that their presence increases with worsening obesity .children are likely to be the ideal candidates for providing insight into the myocardial changes related to obesity because they are suggested to be free of other cardiovascular risk factors indifferent echocardiographic studies .

Official Title
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Cardiac Assessment of Obese and Overweight Children Attending Asyut University Children Hospital

Conditions
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Obesity, Childhood

Intervention / Treatment
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* Device: Echocardiography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Age: children at 2-18 years . - Overweight children whose body mass index at or above the 85th percentile and below the 95th percentile for the same age and sex - Obese children whose body mass index at or above the 95th percentile for the same age and sex. Exclusion Criteria: 1- Obese children below two years 2 - Cases with syndromic obesity, diabetes thyroid and parathyroid and those with congenital heart diseases

Ages Eligible for Study
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Minimum Age: 2 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Echocardiography|Echocardiographic parameters in obese and overweight|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiac assessment of obese and overweight children | Echocardiography performed by an expert cardiologist using a Philips envisor c machine to assess the following parameters (left ventricle end-diastolic diameter (LVEDD), left ventricle end-systolic diameter (LVESD), interventricular septal systolic diameter (IVSSD), interventricular septal diastolic diameter (IVSDD) left ventricle fraction shortening (FS), left ventricle ejection fraction (EF), left atrium to aorta ratio (LA:AO), mitral annular plane area systolic excursion (MAPSE), fraction area shortening of the right ventricle (FAC), tricuspid annular plane systolic excursion (TAPSE) | Baseline | 
| Assessment of body mass index | BMI described in kg / m² | baseline |