Establishment and Validation of a Predictive Model for the Risk of Colorectal Advanced Adenomas

Study Overview
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Brief Summary
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The study aimed to analyze the risk factors of colorectal advanced adenoma and constructe a model to predict the high-risk individuals of harbouring colorectal advanced adenomas, so as to better identify screening participants and provide an important theoretical basis for the prevention of colorectal cancer.

Detailed Description
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A large cohort of eligible patients were included in the analysis, and classified into derivation and validation cohorts at a ratio of 7:3. Demographic and clinicopathological characteristics of participants were utilized to develop a prediction model for colorectal advanced polyps. In the derivation cohort, the LASSO regression method was applied to filter variables and multivariate logistic regression analysis was used to identify important predictors.A prediction model was established based on the results of multivariate logistic regression analysis. The predictive performance of the model was evaluated with respect to its discrimination, calibration and clinical usefulness.

Official Title
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Establishment and Validation of a Predictive Model for the Risk of Colorectal Advanced Adenomas

Conditions
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Colorectal Adenoma

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged ≥18 and ≤75 years old. Patients with complete data on demography and clinicopathology. Exclusion Criteria: Patients with a history of inflammatory bowel disease, enterophthisis, familial adenomatous polyposis, P-J syndrome and intestinal lymphoma. Patients with a previous history of colorectal neoplasm. Patients with a history of severe systemic diseases. Lack of complete clinical data for analysis.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients with colorectal advanced adenomas<br> | |
| patients without colorectal advanced adenomas<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Demographic characteristics of patients with colorectal adenomas checklist | Age (years), sex (man/woman), family history of colorectal cancer (in first-degree relatives, including parents and siblings), history of smoking (never, past, current), history of alcohol consumption (never, past, current), regular use of non-steroidal anti-inflammatory drugs | 1 year | 
| weight (kilograms) | Clinicopathological characteristics of patients with colorectal adenomas | 1 year | 
| height (meters) | Clinicopathological characteristics of patients with colorectal adenomas | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The important high-risk factors of colorectal advanced adenoma | The important high-risk factors with p value < 0.05 | 1 year |