Probiotics and Overreaching Recovery

Study Overview
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Brief Summary
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Overloading is a key training principle used by athletes and coaches to improve physical performance. Intensified training periods are therefore commonly incorporated into the course of a regular training season. From a clinical point of view, very intense periods of training are associated with a temporary immunological deficiency which can lead to teh overreaching syndroms. During periods of overreaching, nutritional strategies are mainly aimed at ensuring sufficient amounts of energy to support the increase in effort. However less is known about nutritional supplements to attenuated the inflammatory/immunological response to training stress. Probiotic bacteria are defined as live food ingredients beneficial to the host's health. Numerous health benefits have been attributed to probiotics, including effects on gastrointestinal tract function and disease, immune function, hyperlipidemia, hypertension, and allergic conditions. Studies in the literature on the ergogenic effect of probiotics in athletes are still scarce today. this study aims to explore the potential role of probiotics on performance, recovery from fatigue and immune function during intensive period of training.

Official Title
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Probiotics for Athlete's Recovery and Immune System

Conditions
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Fatigue; Muscle, Heart, Immunosuppression

Intervention / Treatment
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* Dietary Supplement: probiotics
* Dietary Supplement: placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age 25-55 years Body mass index:> 18 and <30 kg / m2 Stable body weight for at least 3 months regular practice of physical activity for at least 2 years Exclusion Criteria: Chronic diseases (cardiovascular, hepatic, respiratory, cancer) Acute inflammatory states, infections or other pathologies Regular use of probiotics Use or treatment with steroids (within the previous 3 months)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Probiotics<br>participants will train for 15 days while consuming the dietary supplement. During the last 8 days the intensity of training will increase to induce overreaching. | Dietary Supplement: probiotics<br>* participants will be given probiotics twice a day for 15 days<br>|
| Placebo Comparator: Placebo<br>participants will train for 15 days while consuming the dietary supplement. During the last 8 days the intensity of training will increase to induce overreaching. | Dietary Supplement: placebo<br>* participants will be given a placebo twice a day for 15 days<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| lymphocyte subpopulation total T (CD3+) | lymphocyte subpopulation: total T (CD3+) % | Change from baseline to up to 15 days | 
| T-helper (CD4+) | lymphocyte subpopulation: T-helper (CD4+) % | Change from baseline to up to 15 days | 
| T-suppressor (CD8+) | lymphocyte subpopulation: T-suppressor (CD8+) % | Change from baseline to up to 15 days |