Comparison of TUSP Versus TURP for Treatment of Benign Prostatic Hyperplasia in a Small Prostate Volume

Study Overview
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Brief Summary
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Comparison of transurethral split of the prostate versus transurethral resection of the prostate for treatment of benign prostatic hyperplasia in a small prostate volume: A prospective controlled study

Detailed Description
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Transurethral resection of the prostate (TURP) was considered as the golden standard to treat benign prostatic hyperplasia (BPH) for decades. However, TURP was associated with low efficiency to alleviate the lower urinary tract symptoms and a significantly higher risk of bladder neck contracture (BNC) for patients with small-volume BPH. We aimed to compare the therapeutic effect of transurethral split of the prostate (TUSP) with TURP for patients with small-volume BPH (<30 ml). In this study, some selected small-volume BPH patients were randomly divided into two groups (TUSP and TURP group). The patient's baseline characteristics and perioperative outcomes were recorded. The follow-up was made at 6 months, 1 year and 2 years after surgical treatment.

Official Title
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Comparison of Transurethral Split of the Prostate Versus Transurethral Resection of the Prostate for Treatment of Benign Prostatic Hyperplasia in a Small Prostate Volume: A Prospective Controlled Study

Conditions
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Benign Prostatic Hyperplasia

Intervention / Treatment
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* Procedure: TUSP
* Procedure: TURP


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Benign prostatic hyperplasia patients with surgical indication Maximum flow rate <12ml/s Prostate volume <30ml The international prostate symptoms score>21 Medication of α-adrenergic blockers for at least 3 months Exclusion Criteria: Acute prostatitis and urethritis Neurogenic bladder Abnormal prostate-specific antigen level Urethral injury history

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Test Group<br>Patients received the transurethral split of the prostate(TUSP) treatment. | Procedure: TUSP<br>* Patients received the transurethral split of the prostate(TUSP) treatment.<br>|
| Active Comparator: Control Group<br>Patients received the transurethral resection of the prostate(TURP) treatment. | Procedure: TURP<br>* Patients received the transurethral resection of the prostate(TURP) treatment.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| international prostate symptoms score（IPSS） | Measuring the International Prostate Symptoms Score by a questionnaire (which minimum value is zero and the maximum value is 35; higher scores mean a worse outcome) | within 24 months after surgery | 
| maximum urinary flow rate（Qmax） | Measuring the maximum urinary flow rate by a urodynamic study | within 24 months after surgery |