Autophagy Markers in Endometrial Polyps

Study Overview
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Brief Summary
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The aim of this research is to evaluate autophagy markers in patients with endometrial polyps

Detailed Description
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Endometrial polyp are benign formations that are frequently encountered in gynecology practice and have malignant potential. It may be asymptomatic in the clinic or may present with abnormal uterine bleeding. Although its pathophysiology has not been clearly revealed, there are many studies in the literature about it. However, the autophagy pathway emerges as a subject that has never been evaluated. In this study, the investigators would like to prospectively evaluate Beclin 1, LC3A / B and p62 markers in the autophagy pathway in endometrial polyp tissue samples by immunohistochemistry and reveal their importance.

Official Title
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Investigation of Autophagy Markers in Endometrial Polyps

Conditions
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Endometrial Polyp, Autophagy

Intervention / Treatment
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* Genetic: Beclin 1 gene


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients over 35 years of age with a histopathologically confirmed diagnosis of endometrial polyp patients over the age of 35 whose histopathologically reported normal endometrial biopsy results. Exclusion Criteria: Are under the age of 35, those with cognitive dysfunction, diagnosed with any type of cancer who are under treatment for cancer, diabetes mellitus, hypertension, endometriosis, adenomyosis, chronic endometritis, have an acute or chronic illness, patients who have smoked and used alcohol in the last 10 years

Ages Eligible for Study
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Minimum Age: 35 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Study group<br>endometrial polyp | Genetic: Beclin 1 gene<br>* The determination of Beclin 1, LC3-II and p62 genes, which are evaluated by immunohistochemistry, at the protein level will be done by ELISA method in MSKU Medical Faculty Medical Biology Laboratory.<br>* Other names: p62 gene;|
| Control group<br>normal endometrium | Genetic: Beclin 1 gene<br>* The determination of Beclin 1, LC3-II and p62 genes, which are evaluated by immunohistochemistry, at the protein level will be done by ELISA method in MSKU Medical Faculty Medical Biology Laboratory.<br>* Other names: p62 gene;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| autophagy marker | Beclin 1 gene level | through study completion, an average of 1 year | 
| autophagy marker | LC3II gene level | through study completion, an average of 1 year | 
| autophagy marker | p62 gene level | through study completion, an average of 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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polyp, endometrium, beclin 1, LC3, p62