Vestibular Socket Therapy in Immediate Implants With Grafting Materials

Study Overview
=================
Brief Summary
-----------------
The current research aims at evaluating the outcomes of the vestibular socket therapy in immediate implants using collagen plug, demineralized freeze-dried bone allograft, and deproteinized bovine bone minerals at both radiographic and clinical levels

Official Title
-----------------
A Comparative Study Evaluating Vestibular Socket Therapy in Immediate Implants Using Different Grafting Materials

Conditions
-----------------
Tooth Extraction, Dental Implant, Extarction Socket

Intervention / Treatment
-----------------
* Other: VST with collagen plug soaked in blood
* Other: VST with Allograft Demineralized bone matrix Grafton
* Other: VST with a particulate bone graft composed of two thirds autogenous cortical chips harvested from the surgical site and one third of bovine deprotinzed particles


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients will be included if they have one or more hopeless teeth without signs of acute infection in the maxillary anterior region. Remaining roots or non-restorable teeth with sufficient bone apically and palatably to allow proper implant positioning with sufficient primary stability. Optimal compliance as evidenced by no missed treatment appointments and a positive attitude towards oral hygiene. Medically free Exclusion Criteria: Medically compromised patients and systemic conditions precluding implant and periodontal surgery. Smokers, diabetics, pregnant or lactating women. History of chemotherapy, radiotherapy in head and/or neck region. Bisphosphonate therapy

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: VST with collagen plug soaked in blood<br> | Other: VST with collagen plug soaked in blood<br>* -A sub mucoperiosteal tunnel will be created, a membrane shield will be trimmed to fit the facial wall of the socket and introduced through the tunnel lying over the facial bone plate, and the facial gap will be filled with collagen plug soaked in blood<br>|
| Active Comparator: VST with Allograft Demineralized bone matrix Grafton<br> | Other: VST with Allograft Demineralized bone matrix Grafton<br>* -A sub mucoperiosteal tunnel will be created, a membrane shield will be trimmed to fit the facial wall of the socket and introduced through the tunnel lying over the facial bone plate, and the facial gap will be filled with Allograft Demineralized bone matrix Grafton<br>|
| Active Comparator: VST with autogenous cortical chips and bovine deprotinzed particles<br> | Other: VST with a particulate bone graft composed of two thirds autogenous cortical chips harvested from the surgical site and one third of bovine deprotinzed particles<br>* -A sub mucoperiosteal tunnel will be created, a membrane shield will be trimmed to fit the facial wall of the socket and introduced through the tunnel lying over the facial bone plate, and the facial gap will be filled with a particulate bone graft composed of two thirds autogenous cortical chips harvested from the surgical site and one third of bovine deprotinzed particles<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes in facial plate thickness | Each group will be subjected to: Cone beam computed tomography (CBCT) at baseline, 6 months, and 12months to assess the thickness of the labial (facial) plate of bone and implant survival | at baseline, 6 and 12 months | 
| changes in facial plate height | Each group will be subjected to: Cone beam computed tomography (CBCT) at baseline, 6 months, and 12months to assess height of labial (facial) plate of bone and implant survival | at baseline, 6 and 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes in peri-implant mucosal level | Each group will be subjected to Intraoral scanning at baseline, 6 months and 12 months. The changes in peri-implant mucosal level will be assessed by superimposition of scanning files of different intervals to monitor the changes in surface area calculated by software. | at baseline, 3rd and 6th months |