Clinical Effect of Preventive Use of Tylenol on Fever After Removal of Drainage Tube in Lumbar Fusion Surgery

Study Overview
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Brief Summary
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This study evaluates the influence of Non-steroidal Anti-inflammatory Drugs on preventing fever after the removal of drainage tube in the patients who suffered lumbar fusion surgery, if the outcome turn out positive, the preventive use of non-steroidal anti-inflammatory drugs could decrease the possibility of fever happening when we remove the tube.

Official Title
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Randomized Controlled Study of Fever Probability, Risk Factors and Preventive Use of Non-steroidal Anti-inflammatory Drugs on Fever After Removal of Drainage Tube After Lumbar Fusion

Conditions
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Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Radiculopathy

Intervention / Treatment
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* Drug: Tylenol


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adult patient diagnosis of lumbar spinal stenosis perform decompression and fusion surgery and lay a drainage tube understand the test and could sign the name Exclusion Criteria: beside the inclusion criteria

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Experimental Group<br>preventive use non-steroidal anti-inflammatory drugs to before the removal of drainage tube | Drug: Tylenol<br>* when we decide to remove the drainage tube, we ask the patient to take a pill of tylenol, and another pill in 12h later<br>|
| No Intervention: Control Group<br>without any intervention when remove the drainage tube | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the rate of fever after the removal of drainage tube | we test the temperature of the patient in 24h after the removal of tube, we define fever if the temperature is higher than 37.8 degree | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the level of WBC | we compare the change of the level of WBC of two groups in 24h after the removal of the drainage tube | 24 hours | 
| the level of CRP | we compare the change of the level of CRP of two groups in 24h after the removal of the drainage tube | 24 hours | 
| the level of ESR | we compare the change of the level of ESR of two groups in 24h after the removal of the drainage tube | 24 hours | 
| the temperature | we compare the change of the level of temperature of two groups in 24h after the removal of the drainage tube | 24 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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lumbar spinal stenosis, lumbar fusion surgery, drainage tube, removal of drainage tube, fever, prevention of fever, preventive use of non-steroidal inflammatory drug