Association Between BMI and COVID-19

Study Overview
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Brief Summary
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This study will involve collection of pseudonymized data from hospital-based data reporting at multiple international sites. Collating data from a large volume of patients with COVID-19 admitted in ICU across multiple international sites will enable investigation of whether obesity is a risk factor for complicated from of SARS-CoV-2 in adult patients and whether this association is independent of other cardiometabolic risk factors.

Detailed Description
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The COVID-19 pandemic is characterized by a high frequency of patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), who often require invasive mechanical ventilation (IMV). Body mass index (BMI) was however rarely mentioned in early clinical reports. Disease severity gradually increased with body mass index (BMI) categories among patients admitted in intensive care unit (ICU) for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the need for invasive mechanical ventilation (IMV), reaching 85% in patients with class II or III obesity ( BMI > 35 kg/m2). In summary, there is an urgent need for more evidence on the specific role played by obesity in the development of COVID-19 complications, and more particularly of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)

Official Title
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Relationship Between Obesity and Severe Acute Respiratory Syndrome Coronavirus-2 in Patient With SARS-CoV-2 Admitted in Intensive Care : A Multicenter Retrospective Cohort Study

Conditions
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SARS-CoV 2

Intervention / Treatment
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* Other: Patients admitted to Intensive Care Unit with SARS-CoV2


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participant is aged 18 years or over Has been admitted to ICU with COVID-19 disease. COVID-19 disease has been confirmed by PCR for SARS-CoV-2 Height and weight or BMI on admission has been recorded Data has been collected in an ethical manner as part of a national database or clinical auditing process approved by the local institution or collaboration Exclusion Criteria: -There are no exclusion criteria

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| BMI SARS-CoV-2<br>Patients admitted to Intensive Care Unit with SARS-CoV-2 | Other: Patients admitted to Intensive Care Unit with SARS-CoV2<br>* Patients admitted to Intensive Care Unit with SARS-CoV2<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Relationship between body mass index (BMI) and SARS-CoV-2 | The primary objective of this study is to investigate the relationship between obesity, as determined by body mass index (BMI), and severe pneumonia, as defined by the need of invasive mechanical ventilation ( IMV), among patient admitted in ICU for SARS-CoV-2, across multiple centers, in multiple countries. | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Associations between BMI and outcomes is independent of the known cardiometabolic risk factors | Investigate whether the associations between BMI and outcomes is independent of the known cardiometabolic risk factors, hypertension, diabetes, dyslipidemia, and current smoking. | 3 months | 
| Investigate the modifying effects of age and sex on the associations between BMI and outcome: Invasive mechanical ventilation | Investigate the modifying effects of age and sex on the associations between BMI and outcome: Invasive mechanical ventilation | 3 months | 
| Investigate the modifying effects of age and sex on the associations between BMI and outcome: mortality | Investigate the modifying effects of age and sex on the associations between BMI and outcome: mortality | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Intensive Care, Invasive Mechanical Ventilation, Body Mass Index, Obesity