Long-term Surgical Therapeutic Outcomes of Peri-Implantitis

Study Overview
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Brief Summary
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This study focuses on evaluating the success of different treatment methods for peri-implantitis (gum disease around implants) and to understand the factors that might affect the success of the treatment provided.

Detailed Description
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Qualifying patients will be asked to participate in clinical measurements to compare the long-term success of their treatments. The aims of the current study are to 1) assess the long-term outcome of the surgical treatment of peri-implantitis and to 2) evaluate the success of the different treatment modalities of peri-implantitis.

Official Title
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Long-term Surgical Therapeutic Outcomes of Peri-Implantitis

Conditions
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Peri-Implantitis

Intervention / Treatment
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* Other: Observation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The patient is at least 18 years of age, was initially diagnosed with peri-implantitis at ≥1 implant (peri-implant probing depth (PPD) ≥ 6 mm together with bleeding and/or suppuration on probing (BOP/SoP) and radiologically assessed marginal bone loss ≥ 3 mm), had received treatment for peri-implantitis at least 5 years ago at the Graduate Clinic of Periodontics at University of Michigan, and documentation from ≥ 5 years of clinical and radiological follow-up is available from U of M patients records. Exclusion Criteria: Has received or is currently receiving radiotherapy, are currently pregnant, unsure of their pregnancy status, or are lactating (as reported by the patient), has health condition(s) or takes medication(s) that are known to affect soft tissue or bone (e.g., Phenytoin)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Peri-implantitis<br>Subjects who were diagnosed with peri-implantitis and received treatment at least five years ago at the Graduate Periodontics Clinic at University of Michigan with sufficient baseline data. Soft tissue measurements (observation) of the implant will be completed. | Other: Observation<br>* Soft tissue implant measurements<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Therapeutic resolution of the peri-implantitis as measured by radiographic bone loss | The implant has no further radiographic bone loss when compared to previous radiographs. | At least five years after the implant was treated for peri-implantitis | 
| Therapeutic resolution of the peri-implantitis as measured by erythema | The implant has no current erythema of the peri-implant mucosa. | At least five years after the implant was treated for peri-implantitis | 
| Therapeutic resolution of the peri-implantitis as measured by probing depths | The implant has probing depths less than or equal to 5 millimeters. | At least five years after the implant was treated for peri-implantitis | 
| Survival rate of the peri-implantitis treated dental implants | Survival rate will be determined by the duration of implant survival (functioning, non-symptomatic implant after peri-implantitis treatment). | At least five years after the implant was treated for peri-implantitis |