Severe Septic Shock Complications

Study Overview
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Brief Summary
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Adults older than 18 years old, admitted to the ICU with a Severe Septic Shock, requiring Norepinephrine at more than 0.25mcg/kg/min, who have signed informed consent form, will be consecutively included, from december 2018 to december 2019. The primary goal is to look for risk factors associated with an increased in lactate clearance Secondary goals are the following: To look for risk factors associated with an increase risk of Hospital and ICU length of stay. To look for risk factors associated with an increase risk of Acute Kidney Injury. To look for risk factors associated with a decrease in days alive and free of Mechanical Ventilation, Vasopressors and Renal Replacement Therapy. To look for risk factors associated with a decrease in Ventilator-free days. To look for risk factors associated with a decrease in Vasopressor-free days. To look for risk factors associated with an increase risk of in-hospital mortality. To look for risk factors associated with an increase risk of Myocardial Infarction and myocardial injury. To look for risk factors associated with an increase risk of Acute Respiratory Distress Syndrome. To compare and validate different risk scores in our cohort.

Official Title
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Identifying Risk Factors for Complications in Severe Septic Shock

Conditions
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Septic Shock

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adults older than 18 years old admitted to ICU with Severe Septic Shock Exclusion Criteria: Rejecting participation by not signing informed consent form.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lactate clearance | Time from hospital arrival to documented serum lactate of less than or equal to 2 mmol/L | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Days alive and free of Mechanical Ventilation, Vasopressors and Renal Replacement Therapy | Number of days from the last day free of vasopressors, mechanical ventilation and Renal Replacement Therapy up to day 28. If patients dies it scores 0. | 28 days | 
| Mechanical Ventilation-free days | Days free of mechanical ventilation up to day 28 | 28 days | 
| Vasopressors-free days | Days free of vasopressors up to day 28 | 28 days | 
| Rate of Acute Kidney Injury | Kidney Disease: Improving Global Outcomes definition | 28 days | 
| ICU length of stay | Days in ICU | 28 days | 
| Hospital length of stay | Days in Hospital | 30 days | 
| Rate of In-hospital Mortality | Any cause mortality | 30 days | 
| Rate of Acute Respiratory Distress Syndrome | Berlin definition | 28 days | 
| Rate of New Atrial Fibrilation | New atrial fibrilation requiring treatment | 28 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Severe Septic Shock, Lactate clearance, Acute Kidney Injury, Days alive and free, Ventilation-free days, Vasopressor-free days