Metabolic Effects of One-weak Heavy Drinking

Study Overview
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Brief Summary
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Examination of the effect of one week's unhealthy lifestyle on glucose metabolism and liver parameters in a group of young, healthy males participating in Roskilde Festival 2016.

Detailed Description
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Metabolic effects of intermittent unhealthy lifestyle in otherwise young healthy adults are poorly studied. The investigators evaluated the effect of one week's unhealthy lifestyle on glucose metabolism and liver parameters in a group of young, healthy males participating in Roskilde Festival 2016. Festival participants were studied before and after participation (one week) in Roskilde Festival 2016 and matched with controls who lead a normal life for an equivalent period of time. An oral glucose tolerance test (OGTT), abdominal ultrasound and strain elastography for liver stiffness were performed together with a bioimpedance scan and cognitive tests.

Official Title
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Metabolic Effects of One-Week Heavy Drinking and Fast Food Intake During Roskilde Festival in Young Healthy Male Adults

Conditions
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Metabolic Disturbance, Alcohol; Harmful Use, Glucose Intolerance

Intervention / Treatment
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* Behavioral: Festival participation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: BMI of 18,5-25 kg/m2 Normal liver function (assessed by ASAT, ALAT, GGT, alkaline phosphatase, albumin and bilirubin, coagulation factors II, VII and X, INR and platelets) Exclusion Criteria: Planning alcohol withdrawal or dieting/a special low-fat diet during Roskilde Festival Diabetes or pre-diabetes First degree relatives with diabetes Kidney disease (eGFT<60 ml/min and/or albuminuria) Chronic diseases (in addition to those already mentioned) that could affect participation in festival activities (concerts and parties) Any condition in which the investigator believed would make it impossible to participate

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control subjects<br>1 week of normal daily life and only by the National Health Board recommendated alcohol consumption. | |
| Experimental: Festival subjects<br>1 week's participation in Roskilde Festival 2016 | Behavioral: Festival participation<br>* One week's participation in Roskilde Festival 2016 or living a normal daily life.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Impairment of glucose tolerance | Evaluated by OGTT | First day after intervention week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hepatic steatosis | Evaluated by abdominal ultrasound scan | First day after intervention week |