Post-operative Pain Reduction

Study Overview
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Brief Summary
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Recruited patients with necrotic pulp after application of conventional calcium hydroxide paste are assigned to group, Calcium hydroxide nanoparticle group and Combined Calcium hydroxide with silver nanoparticle group and record postoperative pain afterwards.

Detailed Description
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The investigator will recruit patients who are found eligible to the criteria, conventional calcium hydroxide paste , Calcium hydroxide nanoparticle and Combined Calcium hydroxide with silver nanoparticle . After 48 hours, patients will be randomly assigned to removal of intracanal medication After the visit, patients will be asked to record post operative pain by Numerical Rating Scale)in a given sheet

Official Title
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Post-operative Pain Reduction After Application of Three Intracanal Medicament Within Necrotic Root Canals and Pulp

Conditions
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Effects of the Elements

Intervention / Treatment
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* Drug: Conventional calcium hydroxide paste
* Drug: Calcium hydroxide nanoparticle
* Drug: Combined Calcium hydroxide with silver nanoparticle


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • Medically free patients. Patient's age between 25-50 years. Sex includes both male and female. Radiographic evidence of a periapical radiolucent lesion associated with tooth. Necrotic pulp as indicated by thermal pulp testing. No history of previous endodontic treatment of the tooth. Exclusion Criteria: • Teeth with unfavorable conditions for rubber-dam application. Teeth with acute periapical abscesses swelling. Medically compromised patients. Immature teeth with open apices. Multi rooted teeth. Pregnant women.

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Conventional calcium hydroxide paste<br>Application of Conventional calcium hydroxide paste | Drug: Conventional calcium hydroxide paste<br>* Conventional calcium hydroxide paste (Ultracal) will be removed in second visit.<br>* Other names: Ultracal;|
| Experimental: Calcium hydroxide nanoparticle<br>Application of Calcium hydroxide nanoparticle | Drug: Calcium hydroxide nanoparticle<br>* Calcium hydroxide nanoparticle. manufactured in NanoTech. institute, will be removed in second visit.<br>|
| Experimental: Combined Calcium hydroxide with silver nanoparticle<br>Application of Combined Calcium hydroxide with silver nanoparticle | Drug: Combined Calcium hydroxide with silver nanoparticle<br>* Combined Calcium hydroxide with silver nanoparticle will be removed in second visit.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in post operative pain (Visual Analogue Scale) | Numerical (0-10) | Intrappointment at 4,24,48,72 and 96 hours ] |