Magnetic Resonance Imaging in Myocarditis

Study Overview
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Brief Summary
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The purpose of this study is the assess the diagnostic performance of magnetic resonance imaging in patients with suspected myocarditis by applying different imaging sequences at different MR scanners

Detailed Description
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In patients with clinical suspicion of myocarditis biventricular endomyocardial biopsy is performed for definite diagnosis. In addition, patients undergo magnetic resonance imaging at 1.5 Tesla and 3.0 Tesla within 24 hours. The imaging protocol of both scan include assessment of myocardial edema respectively edema ratio; myocardial hyperemia respectively global relative enhancement (gRE); myocardial fibrosis/necrosis respectively myocardial LE and T1 and T2 mapping sentences. Diagnostic performance of different imaging protocols as compared to the findings of endomyocardial biopsies is calculated. The protocol also includes a follow-up MR can at 3 months.

Official Title
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Myocarditis and the Role of Advanced Magnetic Resonance Imaging

Conditions
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Myocarditis

Intervention / Treatment
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* Other: Endomyocardial Biopsy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Symptoms such as: Dyspnea or Orthopnea or Palpitations or Exercise intolerance or Angina Evidence of myocardial involvement: ventricular dysfunction on echocardiography or new or persistent ECG changes elevated Troponin T History of viral infection Exclusion Criteria: Contraindication for magnetic resonance imaging Impaired renal function: glomerular filtration rate ≤ 30 ml/min/m2 Patients presenting with pregnancy Patients without informed consent Participation in another trial.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Magnetic resonance imaging and endomyocardial biopsy<br>Magnetic resonance imaging and endomyocardial biopsy | Other: Endomyocardial Biopsy<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Accuracy, sensitivity and specificity of magnetic resonance imaging sequences | The diagnostic accuracy of individual and a combination of MR imaging sequences (late enhancement images, assessment of global edema, relative enhancement and T1 and T2 mapping sequences) will be determined by comparison to endomyocardial biopsies, which serve as diagnostic gold-standard | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnostic performance of biventricular endomyocardial biopsies |  | baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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myocarditis, myocardial inflammation, imaging, magnetic resonance