Serum Resistin Level Following Non-surgical Periodontal Therapy in Diabetic Patients With Chronic Periodontitis

Study Overview
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Brief Summary
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non-surgical periodontal debridement was performed for diabetic patients with chronic periodontitis as well as for non-diabetic patients but also with chronic periodontitis. Serum resistin level was assessed in the two groups before and after periodontal therapy and also was compared to a healthy control group.

Detailed Description
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Background: Resisitin is a recognized marker for chronic inflammatory conditions that could be directly linked with type 2 diabetes mellitus. The aim of this study was to assess serum resistin level in type 2 diabetic patients with chronic periodontitis. Methods: Forty individuals were recruited in this study and were divided into three groups, diabetic group consisted of 15 diabetic patients (type 2 diabetes mellitus) with moderate to severe chronic periodontitis, non-diabetic group consisted of 15 non-diabetic patients with moderate to severe chronic periodontitis and healthy group consisted of 10 non-diabetic individuals with healthy periodontium. Non-surgical periodontal therapy with supra and subgingival debridement was performed for the diabetic and non-diabetic groups. Pocket depth, clinical attachment level, plaque index, gingival index, serum Resistin and high sensitivity C-Reactive Protein assay were recorded for both groups before and after treatment, while HbA1c was recorded for the diabetic group.

Official Title
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The Effect of Non-surgical Periodontal Therapy on Serum Resistin Level in Chronic Periodontitis Patients With or Without Type 2 Diabetes Mellitus

Conditions
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Type2 Diabetes

Intervention / Treatment
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* Procedure: non-surgical periodontal therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: diagnosed with moderate to severe chronic periodontitis. Presence of a minimum of 15 natural teeth Presence of at least four teeth with one or more sites with probing pocket depth (PPD) ≥5mm and clinical attachment level (CAL) ≥4mm agreement to participate in the study and sign a written informed consent Exclusion Criteria: Patients who received any periodontal treatment or professional scaling and root planing of the teeth for at least 6 months prior to the study initiation A history of antibiotics therapy and anti-inflammatory drugs within the previous 6 months Pregnancy or use of contraceptives or any medication related to diabetes former or current smokers ˂ 5 years.

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: group1: diabetic patients with chronic periodontitis group2: non diabetic patients with chronic periodontitis
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: diabetic group<br>diabetic patients with chronic periodontitis | Procedure: non-surgical periodontal therapy<br>* supra and subgingival debridement<br>|
| Active Comparator: non-diabetic group<br>non diabetic patients with chronic periodontitis | Procedure: non-surgical periodontal therapy<br>* supra and subgingival debridement<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| serum resistin | ng/ml | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| C-reactive protein | μg/mL | 3 months | 
| probing pocket depth | mm | 3 months | 
| clinical attachment loss | mm | 3 months |