Blood Transfusion Among Patients With Pelvic Fracture in China

Study Overview
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Brief Summary
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According to the patient's blood management concept, this study intends to collect basic information, surgical data, blood transfusion related data and patient prognosis data of patients with pelvic fractures, and to construct a predictive model of intraoperative blood transfusion in patients with pelvic fractures by multiple linear regression analysis. To guide physicians use blood accurately during surgery. Prompt doctors to reduce blood transfusion dose and improve patient prognosis by stopping bleeding and blood recovery before surgery.

Detailed Description
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2.1 Research Objectives: This study aims to construct a blood transfusion model for pelvic fractures, to guide the rational use of blood during surgery, and to improve the prognosis of patients. 2.2 Research content: 2.2.1 Collect basic data, surgical data, blood transfusion related data and patient prognosis related data of patients with pelvic fractures. 2.2.2 Gradually incorporate and exclude data from multiple linear regression models. 2.2.3 Verify the specificity and sensitivity of the intraoperative blood transfusion prediction model. 2.2.4 Create a visualization window to guide clinical blood. 2.2.5 Put into clinical trial and feedback, and continue to verify 2.3 Key issues to be resolved 2.3.1 The factors related to intraoperative blood transfusion in patients with pelvic fractures (such as blood oxygenation, blood loss, HB value, intraoperative autologous blood recovery, blood pressure, heart rate, etc.) were initially screened by univariate analysis. 2.3.2 Reasonably standardize the objective and subjective indicators of different units and different institutions. 2.4 Expected research results Intraoperative blood transfusion prediction model and window for patients with pelvic fractures. 2.5 Assessment indicators Published 1-2 papers. Create a visual applet and put it into trial.

Official Title
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Establishment for Prediction Model of Intraoperative Blood Transfusion for Patients With Pelvic Fracture in China: A Multicenter Observational Study

Conditions
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Pelvic Fracture, Transfusion Reaction, Blood Transfusion Complication

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: (1) 1<Age<80, and Chinese residents living in China more than 3 years; (2) Hemoglobin value less than 100g/L during hospitalization; Exclusion Criteria: (1) Participants who suffered from pelvic fracture within 3 months (2) Participants who suffer from pathological fractures of the pelvis caused by malignant tumors (3) Participants with chronic anemia and coagulopathy (4) Participants who rufuse blood transfusion

Ages Eligible for Study
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Minimum Age: 1 Year
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pelvic fracture patients<br>(1) 1<Age<80, and Chinese residents living in China more than 3 years; (2) Hemoglobin value less than 100g/L during hospitalization; Not suffered from pelvic fracture within 3 months; Not suffer from pathological fractures of the pelvis caused by malignant tumors; without chronic anemia and coagulopathy; accept blood transfusion | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Matta Radiographic Scoring | Reductions were graded by the maximal displacement measured on the 3 standard views of the pelvis. Criteria were: excellent 4 mm or less, good 5 to 10 mm, fair 10 to 20 mm, and poor more than 20 mm. | 6 months of postoperation | 
| Mortality | Mortality during hospitalization | 24 hours after the Patients' Hospitalization | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hb difference | Hb difference before and after transfusion | 24 hours after transfusion | 
| Pain assessed by the VAS | Change in the Pain Intensity Score (0-10 NRS) | 15 minutes, 30 minutes, 1 hours, 2 hours, 4 hours, 6 hours, 12 hours, 18 hours, 24 hours postoperatively | 
| Postoperative Duration of Stay in Hospital of patients | The postoperative duration of stay in hospital of patients between the restrictive transfusion group and the liberal transfusion group are compared. | 52 Weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pelvic Fracture, Predictive Model, Blood Transfusion, Perioperative period