Normal Values for Myocardial Left Atrial Strain

Study Overview
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Brief Summary
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Transversal retrospective and unicentric study. The investigators sought to determine the normal values for two-dimensional myocardial left atrial strain for the cardiology ultrasound system available in their centre (Philips EPIQ ultrasound machine and 10.8.5 QLAB cardiac analysis software). Studies performed in their department which meet the criteria for an adequate strain analysis will be retrospectively reviewed.

Official Title
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Normal Values for Myocardial Left Atrial Strain

Conditions
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Atrial Function

Intervention / Treatment
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* Diagnostic Test: two-dimensional speckle tracking


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: No history of cardiopathy / pneumopathy. No history of hypertension or mellitus diabetes. Exclusion Criteria: Pregnancy. Athletes. Body mass index < 16 or => 30 kg/m2. Previous treatment with cardiotoxic chemotherapy. Dilated left ventricle (telediastolic diameter index > 30 mm/m2). Interventricular septal thickness => 12 mm. Dilated left atria (volume => 31 ml/m2). Systolic pulmonary pressure => 35 mmHg. Moderate or severe valvulopathy. Incomplete or suboptimal left atrial visualization. Frame rate < 50 fps.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: two-dimensional speckle tracking|Analysis of myocardial left atrial strain using two-dimensional speckle tracking echocardiography.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Global peak reservoir strain. | Percentage of peak reservoir strain for 4-, 2- and 3-chambers will be combined to report percentage of global peak reservoir strain. | Through study completion, an average of 4 months. | 
| Global pump strain. | Percentage of pump reservoir strain for 4-, 2- and 3-chambers will be combined to report percentage of global pump strain. | Through study completion, an average of 4 months. | 
| Global conductance strain. | Measured as the difference between global reservoir strain and gobal pump strain. | Through study completion, an average of 4 months. | 
| Global reservoir strain rate. | Reservoir strain rate for 4-, 2- and 3-chambers will be combined to report global reservoir strain rate. | Through study completion, an average of 4 months. | 
| Global conductance strain rate. | Conductance strain rate for 4-, 2- and 3-chambers will be combined to report global conductance strain rate. | Through study completion, an average of 4 months. | 
| Global pump strain rate. | Pump strain rate for 4-, 2- and 3-chambers will be combined to report global pump strain rate. | Through study completion, an average of 4 months. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Age in years |  | Through study completion, an average of 4 months. | 
| Sex | male or female | Through study completion, an average of 4 months. | 
| Weight in kilograms |  | Through study completion, an average of 4 months. | 
| Height in meters |  | Through study completion, an average of 4 months. | 
| Left atrial volume | Measured by biplanar volumetric method | Through study completion, an average of 4 months. | 
| Left ventricular ejection fraction | Measured by biplanar Simpson's method | Through study completion, an average of 4 months. | 
| Left ventricular telediastolic volume | Measured by Simpson's method | Through study completion, an average of 4 months. | 
| Left ventricular dimensions | Assessed by the following parameters: telediastolic diameter, interventricular septal thickness, posterior wall thickness (in mm) | Through study completion, an average of 4 months. | 
| E/A ratio | Transmitral flow profile. | Through study completion, an average of 4 months. | 
| E/e' ratio | Tissue doppler derived parameter. | Through study completion, an average of 4 months. |