ABTECT-1 - ABX464 Treatment Evaluation for Ulcerative Colitis Therapy -1

Study Overview
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Brief Summary
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This is a multicenter, randomized, placebo controlled study to evaluate the efficacy and safety of ABX464 given at 25 or 50 mg QD in inducing clinical remission in subjects with moderately to severely active ulcerative colitis who have inadequate response, no response, a loss of response, or an intolerance to either conventional therapies [corticosteroids, immunosuppressant (i.e. azathioprine, 6-mercaptopurine, methotrexate)] and/or advanced therapies [biologics (TNF inhibitors, anti-integrins, anti-IL-23), and/or S1P receptor modulators, and/or JAK inhibitors].

Official Title
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A Randomized, Double-blind, Placebo-controlled, Multicenter Phase III Study to Evaluate the Efficacy and Safety of ABX464 Once Daily for Induction Treatment in Subjects With Moderately to Severely Active Ulcerative Colitis

Conditions
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Ulcerative Colitis

Intervention / Treatment
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* Drug: ABX464
* Drug: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men or women at least 16 years old; Adolescent subjects will only be enrolled if approved by the country regulatory/health authority. If these approvals have not been granted, only subjects ≥ 18 years old will be enrolled. To be eligible, adolescent subjects must weight ≥ 40 kg and meet the definition of Tanner Stage 5 at the screening visit. Subjects must understand, sign and date the written voluntary informed consent form at the visit prior to any protocol-specific procedures. For under-aged subjects, national requirements regarding consent should also be met. Documented diagnosis of UC > 90 days prior to baseline, confirmed by endoscopy and histology. Should histology results not be available at screening, results from biopsies taken at screening may be used. Active disease defined by modified Mayo score (MMS) ≥ 5 with rectal bleeding subscore (RBS) ≥ 1 and endoscopy subscore (MES) of 2 or 3 (confirmed by central reader). Subjects with documented inadequate response (defined as lack of response or loss of response or intolerance) to at least one of the following treatments: corticosteroids, immunosuppressant, biologic therapies, S1P receptor modulators and/or JAK inhibitors and/or new drugs approved during the study (note: failure to only 5-ASA is not accepted). Women of childbearing potential (WOCBP) subjects and male subjects with WOCBP partner must agree to use highly effective contraception methods Subjects able and willing to comply with study visits and procedures as per protocol. Subjects should be affiliated to a health insurance policy whenever required by a participating country or state Exclusion Criteria: Subjects with ulcerative colitis limited to an isolated proctitis (≤ 15cm from anal verge). Subjects with primary sclerosing cholangitis or autoimmune hepatitis. Subjects who have failed on 5-ASA therapy only. Subjects with CD or presence or history of fistula, indeterminate colitis, infectious/ischemic colitis or microscopic colitis (lymphocytic and collagenous colitis). History or current evidence of toxic megacolon, fulminant colitis, bowel perforation. History of colon cancer, past or current evidence of low grade or high grade colonic dysplasia and/or adenomatous polyps that have not been completely removed. Recent or planned bowel surgery or history of proctocolectomy or partial colectomy or current stoma. Subjects on antidiarrheals (e.g., loperamide, diphenoxylate with atropine, etc.). Subjects on probiotics (e.g., Culturelle® [Lactobacillus GG, i-Health, Inc.], Saccharomyces boulardii). Subjects who do not meet the washout period requirements prior to the screening endoscopy Subjects with the following hematological and biochemical laboratory parameters obtained during the screening period: Hemoglobin ≤ 8.0 g dL-1 Absolute neutrophil count < 750 mm-3 Platelets < 100,000 mm-3 Creatinine clearance < 50 mL.min-1 (Cockroft-Gault formula) Total serum bilirubin > 1.5 x ULN Alkaline phosphatase, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) > 2 x ULN Subjects with the following conditions (infection): Subjects with chronic or recurrent grade 3 or grade 4 infection, or with opportunistic infection within the last 2 months prior to screening. Herpes zoster reactivation within the last 2 months prior to screening. Subjects with active infection at screening or any major episode of infection that required hospitalization or treatment with intravenous antibiotics within 1 month of screening or during screening. Fungal infection of nail beds is allowed. Positive assay or stool culture for pathogens (ova and parasite examination, bacteria) or positive test for Clostridium difficile toxin at screening. If C. difficile is positive, subject may be treated and retested ≥ 2 weeks after completing treatment. Subjects with HIV infection. Subjects having acute or chronic hepatitis B infection at screening (positive for hepatitis B surface antigen [HbsAg], or negative for HbsAg and positive for anti-hepatitis B core antibody in conjunction with detectable HBV DNA, or detectable HBV DNA). Subjects having acute or chronic hepatitis C infection at screening as defined by positive for hepatitis C antibody (subjects successfully treated and without recurrence ≥ 1 year with no detectable HCV RNA [assessed centrally] are eligible). Active tuberculosis (TB) or untreated latent TB are ruled out. For subjects with positive or intermediate QuantiFERON test see section 5.3.8.1 of the current study protocol. Subjects with an uncontrolled ischemic heart disease and/or a history of congestive heart failure with New York Heart Association (NYHA) class 3 or 4 symptoms. Subjects with a family or personal history of congenital or acquired long QT syndrome, or subjects with a marked baseline prolongation of QT/QTc interval (e.g., repeated demonstration of a QTc interval [Fridericia or Bazett correction] >450 milliseconds for male and > 460 milliseconds for female). Subjects with a history of torsade de pointe (TdP). Acute or chronic of clinically relevant pulmonary, hepatic, pancreatic or renal functional abnormality, encephalopathy, neuropathy or unstable central nervous system pathology such as seizure disorder, or any other clinically significant medical problems as determined by physical examination and/or laboratory screening tests and/or medical history (note: treated autoimmune hypothyroidy and autoimmune diabetes are allowed). History or active malignancy (subjects with a 5-year disease free survival are eligible). Serious illness requiring hospitalization within 4 weeks prior to screening (except UC flare). Subjects previously treated with ABX464. Pregnant or breast-feeding women. Illicit drug or alcohol abuse or dependence. Subjects who received live vaccine within 3 months prior to screening and/or who's planning to receive such a vaccine during the study duration. Use of any investigational or non-registered product within 3 months or within 5 half-lives preceding baseline, whichever is longer, and during the study. Any condition, which in the opinion of the investigator, could compromise the subject's safety or adherence to the study protocol

Ages Eligible for Study
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Minimum Age: 16 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: ABX464 50mg<br>Subjects will be orally dosed daily in a fed condition (regular breakfast) in the morning with a glass of water during 8 weeks | Drug: ABX464<br>* Administered once daily in the morning with food<br>* Other names: Obefazimod;|
| Experimental: ABX464 25mg<br>Subjects will be orally dosed daily in a fed condition (regular breakfast) in the morning with a glass of water during 8 weeks | Drug: ABX464<br>* Administered once daily in the morning with food<br>* Other names: Obefazimod;|
| Placebo Comparator: Placebo<br>Subjects will be orally dosed daily in a fed condition (regular breakfast) in the morning with a glass of water during 8 weeks | Drug: Placebo<br>* Administered once daily in the morning with food<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of subjects who achieve clinical remission per Modified Mayo Score at week 8 | To compare the efficacy of ABX464 versus placebo on clinical remission | 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of subjects who achieve endoscopic improvement at week 8 | To compare the efficacy of ABX464 versus placebo on endoscopic improvement | 8 weeks | 
| Proportion of subjects who achieve clinical response per MMS at week 8 | To compare the efficacy of ABX464 versus placebo on clinical response as per MMS | 8 weeks | 
| Proportion of subjects with symptomatic remission at week 8 | To compare the efficacy of ABX464 versus placebo on symptomatic remission | 8 weeks | 
| Proportion of subjects with HEMI per Geboes at week 8 | To compare the efficacy of ABX464 versus placebo on histologic-endoscopic mucosal improvement (HEMI). | 8 weeks |