Organosilane for Surface Cleaning in Intensive Care Units

Study Overview
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Brief Summary
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The purpose of this study is to evaluate if surface disinfection with organosilane associated with traditional cleaning reduces the incidence of healthcare-associated infections (HAIs) in intensive care units when compared with traditional cleaning alone.

Official Title
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Organosilane for Surface Cleaning in Intensive Care Units: A Cluster Randomized, Controlled, Crossover, Clinical Trial

Conditions
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Infection, Hospital

Intervention / Treatment
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* Other: Surface disinfection with Organosilane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients aged 18 years and older who will be admitted to the participating ICUs Exclusion Criteria: Patients under 18 years ICUs that may use any organosilane formulation for surface disinfection

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: Randomized, controlled, cluster, crossover, trial
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Surface disinfection with organosilane<br>Organosilane will be sprayed on the surfaces, using an atomizer. When the environment has been completely covered (i.e., when all surfaces and equipment have a slightly damp film), we will proceed with the second phase of the disinfection of all heavily touched surfaces. surfaces of the bed, with a microfiber cloth with organosilane. | Other: Surface disinfection with Organosilane<br>* Organosilane will be sprayed on the surfaces, using an atomizer. When the environment has been completely covered (i.e., when all surfaces and equipment have a slightly damp film), we will proceed with the second phase of the disinfection of all heavily touched surfaces. surfaces of the bed, with a microfiber cloth with organosilane.<br>|
| No Intervention: Usual surface disinfection<br>The control group will perform standard cleaning and disinfection of the beds and the environment according to their previous protocols, using the usual products. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of healthcare associated infections |  | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Contamination of environmental surfaces by multi-resistant microorganisms | We will collect environmental samples from 4 surfaces highly touched by the patient, health team and family (bed rails, monitor and infusion pump buttons, meal table or procedure table, and IV drip stand) before and after the intervention. (end of the 6 months). For analysis of the environmental samples, characterization of the density and microbiological profile of biofilms on the different surfaces of the ICU beds will be performed using large-scale DNA sequencing techniques associated with bioinformatics analysis. | 6 months | 
| Incidence of ventilator-associated pneumonia |  | 6 months | 
| Incidence of central line-associated blood stream infections |  | 6 months | 
| Incidence of catheter-associated urinary tract infection |  | 6 months | 
| Intensive care unit length of stay costs |  | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Infection Control, Infections, Intensive Care Units, Pneumonia, Ventilator Associated, Catheter-Related Infections, Urinary Tract Infections, Organosilanes, Costs and Cost Analyses