Intestinal Perforation in Patients Receiving an Orthtopic Liver Transplantation in the Montpellier University Hospital

Study Overview
=================
Brief Summary
-----------------
Liver transplantation enhances the prognosis of patients with cirrhoses or hepatocellular carcinoma. However some patients develop intestinal perforations for which the prognosis is poor. The aim of the study is to evaluate the risk factors of intestinal perforations using a retrospective study scheme.

Detailed Description
-----------------
Liver transplantation enhances the prognosis of patients with cirrhoses or hepatocellular carcinoma. However some patients develop intestinal perforations for which the prognosis is poor. The aim of the study is to evaluate the risk factors of intestinal perforations using a retrospective study scheme. Previous studies have shown a possible implication of drugs or medical history or intraoperative complications. The investigators aim to describe the other possible risk factors (such as portal vein clampage) and the type of surgery done after the diagnosis and its impact on survival as well.

Official Title
-----------------
Intestinal Perforation in Patients Receiving an Orthtopic Liver Transplantation in the Montpellier University Hospital: a Retrospective and Observational Study.

Conditions
-----------------
Liver Transplantation, Intestinal Perforation, Digestive System Fistula, Intestinal Fistula

Intervention / Treatment
-----------------
* Procedure: Liver transplantation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients having received an orthotopic liver transplantation in the Montpellier University Hospital from 2014 to 2019 for the group Perforation: patients having during the follow-up a complication such as intestinal perforation. The complete list uses the ICD-10 codes for intestinal perforation, esophageal perforation, duodenal perforation etc. Exclusion Criteria: No exclusion criteria

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Perforation<br>Perforation | Procedure: Liver transplantation<br>* Liver transplantation<br>|
| No perforation<br>No perforation | Procedure: Liver transplantation<br>* Liver transplantation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluate the total length of stay | Evaluate the total length of stay | 1 month | 
| Evaluate the total length of stay | Evaluate the total length of stay | 3 months | 
| Evaluate the total length of stay | Evaluate the total length of stay | 6 months. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluate the occurrence of death | Evaluate the occurrence of death | 1 month, 3 months, 6 months. | 
| Evaluate the total number of complications | Evaluate the total number of complications | 1 month, 3 months, 6 months. | 
| Evaluate the number of perforations | Evaluate the number of perforations | 1 month, 3 months, 6 months. | 
| Evaluate the quality of life | Evaluate the quality of life | 1 month, 3 months, 6 months. | 
| Evaluate the occurrence of an acute or chronic rejection | Evaluate the occurrence of an acute or chronic rejection | 1 month, 3 months, 6 months. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Risk Factors, Survival