Hot Snare Versus Hot Snare Polypectomy With Saline Injection for Colorectal Polyps

Study Overview
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Brief Summary
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The complete removal of colorectal polyp is required to prevent tumor recurrence and development of potential interval cancers. However, several studies have shown high incomplete resection rate in endoscopic removal of neoplastic colorectal polyps larger than 5 mm. The polypectomy techniques using hot snare are usually used for the removal of these polyps. However, the optimal technique for complete resection of these polyps is unknown. There are few data comparing hot snare polypectomy with hot snare polypectomy after saline injection for complete resection of colorectal polyps (5mm or larger). The aim of this study is to compare hot snare polypectomy with hot snare polypectomy after saline injection for removal of 5-10mm sized colorectal polyps.

Official Title
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Hot Snare Polypectomy Vs. Hot Snare Polypectomy After Saline Injection for the Complete Resection of Neoplastic Colorectal Polyps: Prospective, Randomized Controlled Trial

Conditions
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Polyp of Large Intestine

Intervention / Treatment
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* Procedure: hot snare polypectomy
* Procedure: hot snare polypectomy after saline injection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients over the age of 30 5 10mm sized colorectal polyps Informed consent Exclusion Criteria: Inflammatory bowel diseases (Crohn's disease, or ulcerative colitis) Patient undergoing antiplatelets (aspirin, clopidogrel and others) or anticoagulant therapy ASA class III or more Any condition which, in the opinion of the Investigator, places the patient at unacceptable risk if he/she were to participate in the study

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Hot snare polypectomy<br>Intervention: Procedure: removal of eligible polyps using hot snare polypectomy technique | Procedure: hot snare polypectomy<br>* hot snare polypectomy using electrosurgical snare with application of electrocautery for eligible polyps<br>|
| Experimental: Hot snare polypectomy(saline injection)<br>Intervention: Procedure: removal of eligible polyps using hot snare polypectomy after saline injection technique | Procedure: hot snare polypectomy after saline injection<br>* hot snare polypectomy after saline injection using electrosurgical snare with application of electrocautery for eligible polyps<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complete Resection Rate | Complete resection was defined as the absence of residual polyp in the resection margin | 2 weeks after | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lateral Margin | Observation of maring on a recsected specimen | 2 weeks after | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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neoplastic colorectal polyp, hot snare polypectomy, hot snare polypectomy after saline injection