Identification of Biomarkers for Early Detection of Pancreatic Cancer

Study Overview
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Brief Summary
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RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study is examining blood samples from patients with cancer to identify biomarkers that may help in the early detection of pancreatic cancer.

Detailed Description
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OBJECTIVES: Identify specific proteins of interest to evaluate for their potential role as markers for pancreatic cancer. Analyze serum proteins directly by mass spectrometry to identify new biomarkers of pancreatic cancer that can be used for early diagnosis. OUTLINE: Blood from patients is collected prior to treatment. Plasma proteins are analyzed by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS) and/or electrospray mass spectrometry (ESI/MS). PROJECTED ACCRUAL: A total of 120 patients will be accrued for this study.

Official Title
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Michigan Center for Pancreatic Cancer Molecular Diagnosis: The Serum Protein Microarray Project

Conditions
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Pancreatic Cancer

Intervention / Treatment
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* Genetic: protein expression analysis
* Other: laboratory biomarker analysis
* Other: mass spectrometry
* Other: surface-enhanced laser desorption/ionization-time of flight mass spectrometry


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Diagnosis of pancreatic cancer Newly diagnosed disease Planning to undergo surgery or other treatment for pancreatic cancer at Karmanos Cancer Institute or its affiliates PATIENT CHARACTERISTICS: Not specified PRIOR CONCURRENT THERAPY: See Disease Characteristics

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 120 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Genetic: protein expression analysis|Venous blood collection|
|Other: laboratory biomarker analysis|Venous blood collection|
|Other: mass spectrometry|Venous blood collection|
|Other: surface-enhanced laser desorption/ionization-time of flight mass spectrometry|Venous blood collection|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Identification of specific proteins of interest to evaluate for their potential role as markers for pancreatic cancer |  | Upon collection when patient agrees to provide a one time venous blood collection | 
| Analysis of serum proteins directly by mass spectrometry to identify new biomarkers of pancreatic cancer that can be used for early diagnosis |  | After separation from the plasma | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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stage I pancreatic cancer, stage II pancreatic cancer, stage III pancreatic cancer, stage IV pancreatic cancer