Use of Preanesthetic Dexmedetomidine in Elderly, Treated-hypertensive Patients

Study Overview
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Brief Summary
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Background: Dexmedetomidine is an alpha 2 adrenergic agonist with sedative, anxiolytic, and analgesic properties. This study was designed to evaluate the inhibitory effects of preoperative 0.5 μg/kg dexmedetomidine on hemodynamic responses caused by endotracheal intubation in elderly patients being treated for hypertension. Methods: Forty elderly (≥ 65 years) treated-hypertensive patients of American Society of Anesthesiologists physical status II undergoing elective noncardiac surgery were randomly and assigned to two groups. Group C received normal saline and group D received 0.5 μg/kg dexmedetomidine intravenously over 10 min just before endotracheal intubation. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and heart rate (HR) were recorded preoperatively at ward, immediately after study drug administration, and at 1, 3, and 5 minutes after endotracheal intubation.

Official Title
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Effects of Preanesthetic Dexmedetomidine on Hemodynamic Responses to Endotracheal Intubation in Elderly Patients Being Treated for Hypertension: A Randomized Trial

Conditions
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Perioperative Care

Intervention / Treatment
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* Drug: Dexmedetomidine
* Drug: Normal Saline


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: American Society of Anesthesiologists physical status II Scheduled for elective noncardiac surgery Being treated with anti-hypertensive medication Exclusion Criteria: Endotracheal intubation attempted more than twice Morbidly obese (BMI > 35 kg/m2)

Ages Eligible for Study
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Minimum Age: 65 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: dexmedetomidine<br>0.5 mcg/kg dexmedetomidine is administered before endotracheal intubation for 10 minutes | Drug: Dexmedetomidine<br> <br> |
| Placebo Comparator: Normal Saline<br> | Drug: Normal Saline<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in systolic blood pressure | Units of Measure : mmHg | 2 minutes before intubation and 1, 3, 5 minutes after intubation | 
| Changes in diastolic blood pressure | Units of Measure : mmHg | 2 minutes before intubation and 1, 3, 5 minutes after intubation | 
| Changes in mean arterial pressure | Units of Measure : mmHg | 2 minutes before intubation and 1, 3, 5 minutes after intubation | 
| Changes in heart rate | Units of Measure : beats/min | 2 minutes before intubation and 1, 3, 5 minutes after intubation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dexmedetomidine