Development of a Screening Tool By Utilising Cervical Length Measurement In Relation To Body Mass Index (BMI) For Early Identification And Intervention Of Preterm Birth

Study Overview
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Brief Summary
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This is a prospective study where pregnant women between 16-24 weeks gestation attending the Antenatal Clinic, Fetomaternal clinic or Obstetrics & Gynaecology Admission Centre (OGAC) at Hospital Serdang or Hospital Pengajar UPM will be recruited. BMI will be taken both during booking of pregnancy and at recruitment. Cervical length will be measured via transvaginal scan at recruitment time. We aim to assess the association between body mass index, cervical length and risk of preterm birth.

Detailed Description
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General Objective To assess the association between body mass index, cervical length and risk of preterm birth. Specific Objectives To examine the relationship between body mass index and cervical length To identify cut-off value of cervical length leading to high risk of spontaneous preterm birth among Malaysian women To assess the association between different cervical length and preterm birth To examine the association between body mass index and preterm birth To develop an individualised screening tool for assessing risk of preterm birth

Official Title
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Towards Development of an Individualised Screening Tool By Utilising Cervical Length Measurement In Relation To Body Mass Index (BMI) For Early Identification And Intervention Of Preterm Birth

Conditions
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Cervical Length, Preterm Birth

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Singleton pregnancy between 16-24 weeks gestation No history of previous spontaneous preterm birth (gestation between 24-36+6 weeks) Agreement to follow up and consented for the study Exclusion Criteria: Major fetal anomaly Multiple pregnancy Uterine anatomic malformation Those require iatrogenic preterm delivery due to various condition
Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 1. To examine the relationship between body mass index (BMI) and cervical length (CL) | Association of BMI and CL | till February 2023 | 
| 2. To identify cut-off value of cervical length | Value leading to high risk of spontaneous preterm birth among Malaysian women | till February 2023 | 
| 3. To assess the association between different cervical length and preterm birth | Association of CL and PTB | till February 2023 | 
| 4. To examine the association between body mass index and preterm birth | Association of BMI and PTB | till February 2023 | 
| 5. To develop an individualised screening tool for assessing risk of preterm birth | Attributable risk of preterm birth with relation to BMI and CL | Till May 2023 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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body mass index, preterm labour, preterm birth, cervical length