Comparison of Two Different Anesthesia Methods in IVF Procedure

Study Overview
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Brief Summary
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In this study; during the oocyte retrieval procedure, it was aimed to compare two different general anesthesia methods, in which propofol was administered as infusion according to the patient's Bispectral index system (BIS) value or in bolus doses according to the patient's clinic.The hypothesis of the study; during the oocyte retrieval process, when propofol is administered as an infusion and accompanied by BIS monitoring, adequate anesthesia level will be achieved with less amount of bolus doses according to the clinical condition of the patient.

Detailed Description
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130 patients over the age of 18, ASA I-II, who underwent oocyte retrieval for IVF treatment were included in the study. The patients divided into two groups. In induction, 2mg/kg fentanyl, 40mg lidocaine and 2mg/kg propofol administered to all patients. Patients in group 1; propofol added in bolus doses of 0.5mg/kg. Doses determined according to the clinical condition of the patient. Patients in group 2; propofol administered as 10mg/kg/hour infusion. The infusion dose adjusted so that the Bispectral index (BIS) is in the range of 40-60.

Official Title
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Comparison of Two Different Anesthesia Methods During Oocyte Retrieval for in Vitro Fertilization

Conditions
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Oocyte Retrieval

Intervention / Treatment
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* Drug: propofol bolus
* Drug: propofol infusion


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Over 18 years ASA I-II Patients who underwent oocyte retrieval for IVF treatment Exclusion Criteria: The patient does not want to participate ASA > II patients Patients under 18 years of age Patients who are allergic to the drugs used Patients with mental illness Patients with alcohol or substance addiction

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group bolus<br>Propofol will be administered in bolus doses of 0.5mg/kg. Doses will be determined according to the clinical condition of the patient. | Drug: propofol bolus<br>* Propofol will be added in bolus doses of 0.5mg/kg.<br>|
| Active Comparator: Group infusion<br>Propofol will be administered as 10mg/kg/hour infusion. The infusion dose will be adjusted so that the Bispectral index (BIS) is in the range of 40-60. | Drug: propofol infusion<br>* Propofol will be administered as 10mg/kg/hour infusion.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Propofol | The total amount of Propofol (mg) administered during the procedure | up to 1 hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Observer's assessment of sedation scale (OSS) | Time to reach 5 on the observer's assessment of sedation scale of the patients | up to 1 hour | 
| (Post Anesthetic Discharge Scoring System) PADSS | Time of patients to reach PADSS ≥ 9 (Min:0 and Max: 10) PADSS ≥ 9 is suitable for discharge of the patient | up to 6 hour | 
| (Satisfaction of patients) STF 1 | Patient satisfaction (The scale is in the range of 1-4. 1: the best) | up to 6 hour | 
| (Satisfaction of gynecologist) STF 2 | Satisfaction of the doctor performing the procedure(The scale is in the range of 1-4. 1: the best) | up to 1 hour |