Effective Rehabilitation of Patients Operated With Total Knee Arthroplasty

Study Overview
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Brief Summary
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The purpose of this study is to investigate the effect of maximal strength training (MST) compared to standard rehabilitation in patients operated with total knee arthroplasty. Previous studies report reduced physical function and muscle strength despite successful surgery inserting an artificial implant. Furthermore, great loss of muscle strength has been found in these patients in the early postoperative phase. The study is a randomized controlled trial. The investigators hypothesize that MST will increase muscle strength and physical function more than standard rehabilitation.

Official Title
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Effective Rehabilitation of Patients Operated With Total Knee Arthroplasty

Conditions
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Osteoarthritis

Intervention / Treatment
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* Other: Maximal strength training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: unilateral osteoarthritis, < 75 years Exclusion Criteria: disease(s) that compromise testing/training, unable to understand written and verbal instructions and information, osteoarthritis in the contralateral leg that needs treatment.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Maximal strenght training<br>Training maximal strength training 3 times a week/1 physiotherapy session for 8 weeks | Other: Maximal strength training<br> <br> |
| No Intervention: Standard rehabilitation<br>2-3 physiotherapy sessions a week for 8 weeks/telephone contact by project leader once a week/writing training diary | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle strength in leg extension and leg press | Measured preoperatively implies measuring the outcome within the last month prior to surgery | Measured preoperatively, after 7 days, 10 wks and 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 6 minute walk test | Measuring the outcome preoperatively implies testing within the last month prior to surgery | preopertively, 7 days postoperatively and after 1 year | 
| KOOS; Knee injury and osteosarthritis outcome score |  | Preoperatively (within 1 month prior to surgery), 7 days postoperatively and 10 wks and 1 year postoperatively | 
| EQ-5D (measure of health outcome) |  | Preoperatively (within 1 month prior to surgery), 7 days, 10 wks and 1 year postoperatively | 
| VAS scale recording pain |  | preoperatively (within 1 month prior to surgery), 7 days, 10 wks and 1 year postoperatively | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Resistance training