Cardiovascular Effects of Sporting Events

Study Overview
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Brief Summary
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Major sporting events may have adverse cardiovascular effects in subjects with coronary heart disease. We also hypothesized that the adverse cardiovascular effects of sporting events are a result of psychobiological processes including stress-induced hemodynamic changes, autonomic dysfunction and parasympathetic withdrawal, and inflammatory and prothrombotic responses, all of which may in turn promote myocardial ischemia.

Detailed Description
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Observational studies suggest that exposure to sporting events may worsen symptoms of angina and trigger acute myocardial infarction. The mechanisms for this association are unknown. To date, there have been no controlled exposures in patients with coronary heart disease: an important population who may be particularly susceptible to the adverse cardiovascular effects of sporting events. In a randomized crossover controlled study, 38 patients with prior myocardial infarction will be exposed to sporting events or not. Myocardial ischemia will be quantified by ST-segment analysis using continuous 12-lead electrocardiography, and blood pressure change will be analyzed using ambulatory blood pressure monitoring. Autonomic function will be assessed by heart rate variability. Ischemic, inflammatory and prothrombotic markers will also be measured.

Official Title
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Cardiovascular Effects of Major Sporting Events in Subjects With Coronary Heart Disease

Conditions
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Coronary Heart Disease

Intervention / Treatment
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* Behavioral: Exposure to sporting events
* Behavioral: No exposure to sporting events


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Previous myocardial infarction (>6 months previously)treated by coronary revascularization On standard secondary preventative therapy Exclusion Criteria: Angina pectoris (Canadian Cardiovascular Society grade ≥2) History of arrhythmia Uncontrolled hypertension Unstable coronary disease (acute coronary syndrome or unstable symptoms within 3 months) Occupational exposure to sporting events Diabetes Hepatic or renal failure

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sham Comparator: 1<br>No exposure to sporting events | Behavioral: No exposure to sporting events<br>* No exposure to sporting events<br>|
| Experimental: 2<br>Exposure to sporting events | Behavioral: Exposure to sporting events<br>* Exposure to sporting events<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evidence of definite myocardial ischemia confirmed by Holter monitoring |  | 2 months | 
| Blood pressure measured by ambulatory blood pressure monitoring |  | 2 months | 
| Heart rate variability |  | 2 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Episode of angina |  | 3 months | 
| Episode of neurological events |  | 3 months | 
| Episode of arrhythmia |  | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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sporting events, stress, myocardial ischemia, ST-segment depression, blood pressure