Evaluation of Respiratory Muscle in Patient With Pulmonary Arterial Hypertension

Study Overview
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Brief Summary
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The aim of the study is that evaluation of basic and accessory respiratory muscles and their relationship of six minute walk test in patient with pulmonary arterial hypertension (PAH)

Official Title
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Evaluation of Primary and Accessory Respiratory Muscles and Their Influence on Exercise Capacity and Dyspnea in Pulmonary Arterial Hypertension

Conditions
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Pulmonary Artery Hypertension

Intervention / Treatment
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* Diagnostic Test: patient assessment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with diagnosis of pulmonary arterial hypertension patients with stabil drug therapy at least three months Exclusion Criteria: patients with obstructive and/ or restrictive lung disease comorbidity severe orthopedic and/ or neurological comorbidity patients with heart failure patients with ischemic heart disease uncooperative patients

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 64 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients<br>Maximal mouth pressure will be evaluated for determine respiratory muscle strength, m. pectoralis, m. serratus anterior, m. sternocloideumasteoideus and quadriceps muscles strengths will be measured to evaluate accessory respiratory muscle strength, London chest activity of daily living scale will be done for assessment of dyspnea and six minute walk test will be used for determination of functionally capacity | Diagnostic Test: patient assessment<br>* subjective and objective measurement will be performed in patients with PAH<br>|
| Control group<br>Maximal mouth pressure will be evaluated for determine respiratory muscle strength, m. pectoralis, m. serratus anterior, m. sternocloideumasteoideus and quadriceps muscles strengths will be measured to evaluate accessory respiratory muscle strength, London chest activity of daily living scale will be done for assessment of dyspnea and six minute walk test will be used for determination of functionally capacity | Diagnostic Test: patient assessment<br>* subjective and objective measurement will be performed in patients with PAH<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pectoralis muscle strength | pectoralis muscle strength will be evaluated with hand held dynamometers according to muscle test technique | 15 minute | 
| serratus anterior muscle strength | Serratus anterior muscle strength will be evaluated with hand held dynamometers according to muscle test technique | 15 minutes | 
| sternocleidomasteoideus muscle strength | sternocleidomasteoideus muscle strength will be evaluated with hand held dynamometers according to muscle test technique | 15 minutes | 
| Respiratory mouth pressure | Respiratory mouth pressure will be measured to determine maximally inspiratory pressure and maximally expiratory pressure according to ATS/ERS guidelines. | 15 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Six Minute Walk Test (6MWT) | Six minute walk test will be performed to evalute functionally exercise capacity according to ATS/ERS guidelines | 30 minutes | 
| Dyspnea assessment | London Chest Activity of Daily Living Scale will be used to sensation of dyspnea during activity of daily living.The scale consists of four domains: self-care (four items), domestic (six items), physical (two items) and leisure (three items). In total, the scale consisting of 15 items scored of 0 to 5. 0 means that I wouldn't do anyway and 5 means that Someone else does it for me. Higher values indicate greater limitation due to the dyspnea | 20 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dyspnea, respiratory muscle strength, exercise capacity, accessory respiratory muscle