Run, Recovery, Repeat, Always Healthy (Corre, Recupera, Repite, Siempre Saludable)

Study Overview
=================
Brief Summary
-----------------
This study has as main objective to know how the processes of recovery are realized after a race of marathon. For this, the participants of a marathon race are divided into three work groups during the 9 days post-marathon, one with rest in the recovery period, another with continuous race three sessions every 48h and another with three sessions of elliptical every 48h .

Detailed Description
-----------------
The marathon runners suffer a high fatigue, as has been studied by different investigations, the proposal of this study is to know how the recovery processes are produced in runners who have completed a 42km test. To do this, baseline measurements of the runners have been made through stress tests and determinations of biomarkers in blood and urine. Subsequently blood and urine samples were taken the day before the marathon test and blood and urine samples were then taken again on arrival at 24h, 48h, 96h, 144h, and 196h. At the same time, an intervention was carried out in the recovery phase, with the runners in three groups. The first one performed rests during the 9 days after the race, the second performed continuous race monitored every 48h from the end of the race, and the third group performed aerobic work on an elliptical machine under the same conditions as the group of Continuous race

Official Title
-----------------
Corre, Recupera, Repite, Siempre Saludable.

Conditions
-----------------
Physical Exertion

Intervention / Treatment
-----------------
* Other: Athletics track
* Other: Elliptical machine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adults healthy with 30-45 years BMI between 16-24,99 Time in marathon between 3h-4h in men Time in marathon between 3h:30min-4h:40min in women Exclusion Criteria: Having heart disease Having kidney disease Taking a medication on an ongoing basis

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: The first one performed rests during the 9 days after the race, the second performed continuous race monitored every 48h from the end of the race, and the third group performed aerobic work on an elliptical machine under the same conditions as the group of Continuous race
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Rest Group<br>Rest during the 9 days after the race | |
| Experimental: Running Group<br>Running at 95-105% aerobic Threshold on athletics track 48h, 96h, 144h after the race. Control heart devices | Other: Athletics track<br>* Running at 95-105% aerobic Threshold on athletics track 48h, 96h, 144h after the race. Control heart devices<br>|
| Experimental: Elliptical Group<br>Running at 95-105% aerobic Threshold on elliptical machine 48h, 96h, 144h after the race. Control heart devices | Other: Elliptical machine<br>* Running at 95-105% aerobic Threshold on elliptical machine 48h, 96h, 144h after the race. Control heart devices<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in the Blood Physiological parameters | Blood test | baseline, 0, 24, 48, 96, 144 and 192 hours post-race | 
| Analysis of tne changes in the Physical activity data | Physical activity measured by wearing accelerometer devices. Physical activity defined as sedentary, light, moderate and vigorous. The aim to wear accelerometers devices is to monitor individuals during recovery time post-marathon race | One month before the pre-race, accelerometers were worn during seven days. Accelerometers were also worn during nine days starting from the night before the marathon race | 
| Change in the Urin Physiological parameters | Urin test | baseline, 0, 48, 96, 144 and 192 hours post-race | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Self-reported questionnaire | Personal questionnaire asking for social and training habits | One month before the race day | 
| Strength level | Squat Jump (cm). Two jumps per person | pre-marathon race and 0, 48, 96, 144 hours post-marathon race | 
| Analysis of the change of body mass index | BMI | one month before the marathon race day, 24 hours before the marathon race, 2 hours before the marathon race and 10 minutes after the marathon race | 
| Physical Condition | Maximal oxygen consumption | One month before the marathon race day | 
| Body composition | Bioimpedance analysis | One month before the marathon race day | 
| Heart rate | Recording the number of contractions of the heart per minute (bpm) by using a heart rate monitor during all the marathon race | Through marathon completion, an average of 4 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Marathon, runners, biomarkers, recovery