linjc16/ctgov huggingface dataset:
Acute Viral Respiratory Infections in Elderly

Study Overview
=================
Brief Summary
-----------------
This study is designed to assess the causes and impact of acute respiratory illness (common colds, flu, bronchitis, pneumonia) in adults age 65 and older. One of the ways to determine the virus causing a particular illness is to get a blood specimen when a person is sick and again later and look for the body's specific responses that identify the virus. Approximately 3000 subjects will be evaluated and their medical records assessed for details of recent illness and general health to help in understanding the subjects' current illness.

Detailed Description
-----------------
The purpose of this study is to determine the role of respiratory viruses in the etiology of medically attended acute respiratory illness in elderly populations and to assess the impact of these illnesses. Ambulatory elders presenting for health care with an acute respiratory illness will be recruited. Nose and throat swab specimens will be collected to test for one of the respiratory viruses, and acute and convalescent blood specimens will be collected to test for increases in specific antibody. Specimens will be collected within seven days of the onset of illness and then 1 month later for comparison specimens. A brief questionnaire will accompany the specimens, and more complete data on the illness and consequences will be obtained from the medical record. The pattern of illnesses by virus and their severity and duration will be determined.

Official Title
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Etiology and Impact of Acute Viral Respiratory Infections in Ambulatory Elderly Populations

Conditions
-----------------
Respiratory Infections, Acute

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 65 years of age or older Presentation to the geriatric clinic with an acute respiratory illness of less than 7 days' duration. Exclusion Criteria: Presentation to the geriatric clinic with a history of a respiratory illness of greater than 7 days' duration. Physician/physician assistant judgment that the respiratory complaints do not represent an acute infection. Patient declines to permit specimen collection.

Ages Eligible for Study
-----------------
Minimum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| observation<br>male and female adults age 65 and older with acute respiratory illness (common colds, flu, bronchitis, pneumonia) | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
respiratory illness, influenza, bronchitis, pneumonia, cold
Variability in Thermal Thresholds in Patients With Persistent Pain After Open Inguinal Herniotomy

Study Overview
=================
Brief Summary
-----------------
The study will investigate the test-retest variability of thermal thresholds in patients with persistent pain after open inguinal herniotomy. Sensory mapping with a cool metal roller delineated an area with cool sensory dysfunction on the painful site. In this area and in a contralateral area as a control, 5 sites were outlined, including the point of maximum pain. In these total 10 sites warmth detection threshold (WDT), cool detection threshold (CDT) and heat pain threshold (HPT) were assessed using quantitative sensory testing. Tests were repeated after a 4-6 weeks interval.

Official Title
-----------------
Variability in Thermal Thresholds in Patients With Persistent Pain After Open Inguinal Herniotomy

Conditions
-----------------
Persistent Pain After Open Inguinal Herniotomy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with persistent pain after open inguinal herniotomy Age > 18 years Exclusion Criteria: Cognitive impairment Drug or alcohol abuse Bilateral inguinal hernia operation Nerve injury from other causes
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Test- retest variability of thermal thresholds. | Analysis of agreement (Bland-Altman) and reliability (intraclass correlation coefficients) of thermal threshold test- retest data assessed at baseline and after 4-6 weeks. | At baseline and retest 4-6 weeks later |
Mortality, Morbidity and Risk Factors of Liver Retransplantation

Study Overview
=================
Brief Summary
-----------------
This study aims to compare the short and long term outcomes of living donor and deceased donor liver retransplantation. Bearing that in mind, the investigators will retrospectively analyze the files of patients whom underwent a liver retransplantation in Memorial Bahcelievler Hospital Organ Transplantation Center.

Official Title
-----------------
Comparison of Mortality, Morbidity and Risk Factors in Living- Donor and Deceased-Donor Liver Retransplantation

Conditions
-----------------
Liver Transplant; Complications, Liver Transplant Rejection, Liver Transplant Failure, Liver Diseases, Liver Cirrhosis, Liver Failure, Organ Transplant Failure or Rejection

Intervention / Treatment
-----------------
* Other: Liver Transplantation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Having a liver retransplantation Exclusion Criteria: N/A

Ages Eligible for Study
-----------------
Minimum Age: 0 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with Living Donor Liver Transplantation<br> | Other: Liver Transplantation<br>* Liver Transplantation<br>|
| Patients with Deceased Donor Liver Transplantation<br> | Other: Liver Transplantation<br>* Liver Transplantation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Survival ratio | Overall graft and patient survival ratio | 1 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Morbidity | Postoperative complications such as septicemia, hepatic artery thrombosis etc. | 10 minutes | 
| Peri-operative informations | Peri-operative informations such as blood loss during surgery | 15 minutes | 
| Blood Test Results | Patients' blood test results specific to liver such as International Normalization Ratio | 20 minutes |
500mg Fulvestrant Versus Exemestane in MBC

Study Overview
=================
Brief Summary
-----------------
500mg Fulvestrant versus Exemestane in MBC

Detailed Description
-----------------
500mg Fulvestrant versus Exemestane in Metastatic Breast Cancer (MBC) resistant to adjuvant Non-steroidal Aromatase Inhibitors in clinical practice- a multicenter retrospective study

Official Title
-----------------
500mg Fulvestrant Versus Exemestane in Metastatic Breast Cancer (MBC) Resistant to Adjuvant Non-steroidal Aromatase Inhibitors in Clinical Practice- a Multicenter Retrospective Study

Conditions
-----------------
Breast Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Postmenopausal woman, age > 18 years old Diagnosed with ER/PR+，HER2- Metastatic Breast Cancer Adjuvant treatment of Non-steroidal Aromatase Inhibitors First line of Metastatic Breast Cancer is 500mg Fulvestrant or Exemestane for at least one month, starting from 2014.01.01-2017.06.01 Available medical history Exclusion Criteria: Incomplete medical history

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Fulvestrant<br>Fulvestrant 500 mg on days 0, 14, and 28, and every 28 days thereafter | |
| Exemestane<br>Exemestane 25mg per day | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PFS | Progression free survival | 6 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of participants with treatment-related adverse events as assessed by CTCAE v4.0 |  | 6 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Fulvestrant, Exemestane
Estimation of Injection Volume for Caudal Epidural Block Using Dynamic US Imaging in Children

Study Overview
=================
Brief Summary
-----------------
Caudal epidural block is the most commonly used technique for analgesia in pediatric patients. Although there are clinically used doses of local anesthetics for caudal epidural block, we do not know exactly how much levels are blocked in young children. Thus, we aimed to identify the spreading of injection of local anesthetics for caudal epidural block using ultrasound imaging in young children.

Official Title
-----------------
Estimation of Injection Volume for Caudal Epidural Block Using Dynamic Ultrasound Imaging in Young Pediatric Patients: an Observational Study

Conditions
-----------------
Caudal Epidural Block

Intervention / Treatment
-----------------
* Procedure: ultrasound guided caudal epidural block


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age: 6-24months ASA 1-3 body weight: 5-20kg Exclusion Criteria: patients who refuse to participate local site infection, pilonidal cyst, spina bifida spinal/meningeal abnormality patients who discharge after surgery without admission patients who is judged ineligible for other reasons by the authors

Ages Eligible for Study
-----------------
Minimum Age: 6 Months
Maximum Age: 24 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: ultrasound guided caudal epidural block|dynamic ultrasound imaging of the spread of local anesthetics|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Required volume of local anesthetics | Required volume of local anesthetics to reach each level | 1 day |
A Pilot Study to Investigate Filiation Between Primary and Secondary Lesions in Acne Patients

Study Overview
=================
Brief Summary
-----------------
Exploratory, international, multi-centre, randomized, investigator blinded study in acne

Official Title
-----------------
A Pilot Study to Investigate Filiation Between Primary and Secondary Lesions in Acne Patients

Conditions
-----------------
Acne

Intervention / Treatment
-----------------
* Drug: CD0271 0.1%/CD1579 2.5% gel
* Drug: CD0271 0.1%/CD1579 2.5% gel vehicle


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male or female subjects aged 18 to 35 years inclusive Subjects with active, moderate acne Exclusion Criteria: The subject has a secondary acne form (chloracne, drug-induced acne, etc.) (Screening) The subject has a severity of acne that is not amenable to treatment with CD0271-CD1579 (Screening)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: CD0271 0.1%/CD1579 2.5% gel<br>Split-face design, one application a day for 6 months | Drug: CD0271 0.1%/CD1579 2.5% gel vehicle<br>* one application (pea-sized amount according to the labelling) on a half-face, 5 to 7 days for 6 months<br>|
| Placebo Comparator: CD0271 0.1%/CD1579 2.5% gel vehicle<br>Split-face design, one application a day for 6 months | Drug: CD0271 0.1%/CD1579 2.5% gel<br>* one application (pea-sized amount according to the labelling) on a half-face, 5 to 7 days for 6 months<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Description and documentation of acne lesions |  | over 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Treatment effect on acne lesions |  | over 6 months |
Synbiotics in Infants With Cyanotic Congenital Heart Disease

Study Overview
=================
Brief Summary
-----------------
Infants with congenital heart disease have more frequent infections and exposures to antibiotics than healthy infants. The investigators hypothesized that synbiotics may reduce the rate of sepsis and necrotizing enterocolitis in infants with CHD

Detailed Description
-----------------
Infants with congenital heart disease have more frequent infections and exposures to antibiotics than healthy infants. Probiotics may prevent pathogen colonization in infants with CHD. Therefore, the investigators hypothesized that synbiotics may reduce the rate of sepsis and necrotizing enterocolitis in infants with CHD

Official Title
-----------------
Efficacy of Synbiotics in Infants With Cyanotic Congenital Heart Disease

Conditions
-----------------
Congenital Heart Disease

Intervention / Treatment
-----------------
* Dietary Supplement: Bifidobacterium lactis plus inulin
* Dietary Supplement: Maltodextrin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Cyanotic congenital heart disease infants >35 weeks of gestational age Born at or transferred to Sami Ulus CH Exclusion Criteria: Congenital anomalies of the intestinal tract

Ages Eligible for Study
-----------------
Minimum Age: 1 Day
Maximum Age: 3 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Bifidobacterium lactis plus inulin<br>Bifidobacterium lactis plus inulin | Dietary Supplement: Maltodextrin<br>* same amount of maltodextrin per day will be given as placebo<br>|
| Placebo Comparator: maltodextrin<br>maltodextrin | Dietary Supplement: Bifidobacterium lactis plus inulin<br>* 5 billion unit Bifidobacterium lactis plus 900 mg inulin per day will be given<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sepsis |  | 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Necrotizing enterocolitis |  | 8 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
congenital heart disease, probiotic, prebiotic
Comparison of Different Drilling Speed to Classify Bone Quality by Tactile Sensation on a Saw Bone Model

Study Overview
=================
Brief Summary
-----------------
Comparison of different drilling speed to classify bone quality by tactile sensation on a saw bone model

Detailed Description
-----------------
Bone quality is one of the major factors influencing the dental implant survival rate. Bone quality is believed to have effects on initial implant stability and success of osseointegration. Different implant designs and surgical protocols were developed for improving the survival rate in different bone quality. Although bone quality can be partly diagnosed by radiographic images, lots of experienced surgeons also evaluate bone quality with tactile sensation when they drill the bone. However, variations in evaluation of bone density maybe exist among different surgeons. The drilling speed also may have effect on the outcome of evaluation. For less experienced dentists, it is difficult to diagnose bone quality with tactile sensation in the beginning. The purpose of this study is to find proper drilling speed to classify bone quality by tactile sensation on a saw bone model. Saw bones of variant densities are used as training & testing materials. The proper drilling speed to distinguish different bone quality will be evaluated and offered to junior dentists for better implant treatment outcome.

Official Title
-----------------
Comparison of Different Drilling Speed to Classify Bone Quality by Tactile Sensation on a Saw Bone Model

Conditions
-----------------
Missing Teeth, Dental Implant

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult dentist, with license no more than 5 years No clinical implant surgery experience or with experience less than 10 implants. Exclusion Criteria: -Subject who couldn't hold the test procedure

Ages Eligible for Study
-----------------
Minimum Age: 24 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Units on a Visual Analog Score for bone density | the range of the visual analog score was from 0 to 100, 0 indicated drilling into the air, 100 indicated drilling into the hardest jaw bone. The investigators will provide participants several saw bone blocks with different density. Participants needed to answer each bone density of blocks on the scale by drilling feedback sensation after drilling. It's better result that the answers close to the correct bone density of the saw bone blocks. | 30 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
dental implant, bone quality, tactile sensation, drilling speed
ADC in Assessing Femoral Tunnel Position

Study Overview
=================
Brief Summary
-----------------
To examine the consistency between postoperative CT scan and intraoperative arthroscopic measurement in evaluating femoral tunnel position for anterior cruciate ligament （ACL）reconstruction，both using the apex of the deep cartilage（ADC）as the marker.

Detailed Description
-----------------
The position of the center of femoral tunnel was decided in the complete femoral stub. Then the length from the ADC to the anterior cartilage margin（L1）and to the center of femoral tunnel（l1），as well as the center to the distal cartilage margin（D1）were measured under arthroscopy and on post-operative CT scan（L2，l2 and D2）. Moreover，P1 and P2 were calculated through l1/L1 and l2/L2.

Official Title
-----------------
The Role of the Apex of the Deep Cartilage in Assessing Femoral Tunnel Position for Anterior Cruciate Ligament Reconstruction

Conditions
-----------------
ACL Injury

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adults aged 18-55 who need anterior cruciate ligament reconstruction Exclusion Criteria: Volunteers unsuitable for anterior cruciate ligament reconstruction

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| length from ADC to anterior cartilage margin (L1) under arthroscopy | length from ADC to anterior cartilage margin (L1) under arthroscopy | during operation | 
| length from ADC to the center of femoral tunnel (l1) under arthroscopy | length from ADC to the center of femoral tunnel (l1) under arthroscopy | during operation | 
| length from the center of femoral tunnel to the distal cartilage margin(D1) under arthroscopy | length from the center of femoral tunnel to the distal cartilage margin(D1) under arthroscopy | during operation | 
| length from ADC to anterior cartilage margin (L2) on CT | length from ADC to anterior cartilage margin (L2) on CT | 1 day after operation | 
| length from ADC to the center of femoral tunnel (l1) on CT | length from ADC to the center of femoral tunnel (l1) on CT | 1 day after operation | 
| length from the center of femoral tunnel to the distal cartilage margin(D1) on CT | length from the center of femoral tunnel to the distal cartilage margin(D1) on CT | 1 day after operation | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
femoral tunnel, apex of the deep cartilage（ADC）