Lung Functions in Menopausal Obese Women After COVID 19 Recovery

Study Overview
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Brief Summary
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The COVID-19 pandemic has presented considerable challenges to global health services and dictates almost every aspect of medical practice and policy. The menopausal transition may have significant consequences for respiratory health as COVID 19 symptoms subsides, lung function testing should be done to assess the consequences of this virus on lung health especially in menopausal woman.

Detailed Description
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The study group will consist of (40) obese menopausal women whom were recently recovered from mild-moderate COVID 19 for one month. The control group will consist of (40) obese menopausal women; whom will not affected by COVID 19. Using incentive spirometer, we will measure forced vital capacity FVC, forced expiratory volume FEV, Tiffano index TI and peak expiratory force PEF in both groups.

Official Title
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Assessment of Lung Functions in Menopausal Obese Women After COVID 19 Recovery

Conditions
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Lung Function Decreased, Obesity, Menopause, Covid19

Intervention / Treatment
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* Device: Spirometry


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participants recovered from mild to moderated signs and symptoms of COVID- 19 after one month. Ability to perform pulmonary function tests correctly. COVID-19 was diagnosed by positive polymerase chain reaction (PCR) testing on nasopharyngeal swab, oxygen saturation was ranged between 92-96% during illness period. CT chest shows ground glass opacity. Their D-dimer was less than 0.5 μg/ml. Two successive negative PCR were before included in study. Participants were in home isolation during illness period. Exclusion Criteria: Chronic respiratory disease. Chronic heart disease. Diabetes mellitus. Smoking. Centralized isolation. Severe COVID-19.

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Study group<br>The study group will consist of (20) obese menopausal women whom are recently recovered from mild-moderate COVID-19 after one month. | Device: Spirometry<br>* Spirometry assesses the integrated mechanical function of the lung, chest wall, respiratory muscles, and airways by measuring the total volume of air exhaled from a full lung (total lung capacity [TLC]) to maximal expiration (residual volume [RV]). This volume, the forced vital capacity (FVC) and the forced expiratory volume in the first second of the forceful exhalation (FEV1), should be repeatable to within 0.15 L upon repeat efforts in the same measurement unless the largest value for either parameter is less than 1 L. In this case, the expected repeatability is to within 0.1 L of the largest value.<br>|
| Control group<br>The control group will consist of (20) obese menopausal women; whom are not be affected by COVID-19. | Device: Spirometry<br>* Spirometry assesses the integrated mechanical function of the lung, chest wall, respiratory muscles, and airways by measuring the total volume of air exhaled from a full lung (total lung capacity [TLC]) to maximal expiration (residual volume [RV]). This volume, the forced vital capacity (FVC) and the forced expiratory volume in the first second of the forceful exhalation (FEV1), should be repeatable to within 0.15 L upon repeat efforts in the same measurement unless the largest value for either parameter is less than 1 L. In this case, the expected repeatability is to within 0.1 L of the largest value.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Forced expiratory volume in the first second (FEV1) | is a measurement of your ability to expel air from your lungs. More specifically, and as its name suggests, it is the amount that is exhaled in the first second of purposefully trying to breathe out as much air as possible. | FEV1 will be measured after 1 month post COVID19 recovery. | 
| forced vital capacity (FVC) | is the total amount of air exhaled during the FEV test. | FVC will be measured after 1 month post COVID19 recovery. | 
| FEV1/FVC ratio | The FEV1/FVC ratio, also called Tiffeneau-Pinelli index, is a calculated ratio used in the diagnosis of obstructive and restrictive lung disease. It represents the proportion of a person's vital capacity that they are able to expire in the first second of forced expiration to the full, forced vital capacity. | FEV1/FVC ratio will be measured after 1 month post COVID19 recovery. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Lung funnctions, Menopause, Obesity, Covid19