Hantavirus Nephropathy in North-Eastern France : Severity Risk Factors and Prognostic Tools

Study Overview
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Brief Summary
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Hantaviruses are emerging pathogens responsible for hemorrhagic fever with renal syndrome. Severity risks factors aren't consensual in litterature, mostly related to scandinavian cohorts. A prognostic score was created to help patient's orientation in healthcare system but wasn't independantly validated (Hentzien, Emerging infectious diseases 2018). This retrospective cohort of hantavirus infected hospitalized adults patients in the north-eastern quarter of France between 2013 and 2022 will specify the kidney damage during infection and risk factors for a severe form (defined par acute kidney injury KDIGO 3). The previous prognostic score performance will be evaluated in this cohort.

Official Title
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Hantavirus Nephropathy in North-Eastern France : Severity Risk Factors and Prognostic Tools

Conditions
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Hantavirus Nephropathy, Hantavirus Infection

Intervention / Treatment
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* Other: HANTA-NE


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: hantavirus proven by serology infection age above 18 years Hospitalisation Exclusion Criteria: age under 18 years fulfill opposition form

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 125 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| HANTA-NE<br>All adult patient hospitalized for hantavirus infection between 01/01/2013 and 31/12/2022 in North Eastern France | Other: HANTA-NE<br>* Observational cohort study<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Creatinin level | Acute Kidney injury KDIGO 3 | Through study completion, an average of 2 years | 
| Hemorrhagic syndrome | Major bleeding requiring blood transfusion | Through study completion, an average of 2 years | 
| Death | Death | Through study completion, an average of 2 years | 
| Hospitalisation in intensive care unit | Hospitalisation in intensive care unit | Through study completion, an average of 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Score performance to predict severity | Correlation between severity predicted by the score and bio-clinical severity during hospitalization. Score composition : Hematuria = 7 Visual disorders = 8 Leucocyte count > 10 x 10^9 cells/L = 9 Nephrotoxic drug exposure (NSAID, iodinated contrast media, diuretics, renin angiotensin aldosterone system inhibitors, aminoglycosides, glycopeptides) = 10 Thrombocytopenia < or = 90 000/mm3 = 11 Risk group according score scale 0-10 Low risk 11-19 intermediate risk 20-45 high risk | Through study completion, an average of 2 years | 
| Hypotension | Lowest systolic blood presure during hospitalisation < 90mmHg | Through study completion, an average of 2 years | 
| Proteinuria | Proteinuria during hospitalisation defined by proteinuria/creatininuria above 500 mg/g or equivalent | Through study completion,an average of 2 years | 
| Urinary dipstick | Leucocyturia or hematuria | Through study completion, an average of 2 years | 
| ALAT, ASAT | Liver cytolysis | Through study completion, an average of 2 years | 
| calcium | hypocalcemia, hypercalcemia | Through study completion, an average of 2 years | 
| phosphorus | hypophaspahtaemia, hyperphasphatemia | Through study completion, an average of 2 years | 
| potassium | hypokaliemia, hyperkaliemia | Through study completion, an average of 2 years | 
| sodium | blood sodium level disorders | Through study completion, an average of 2 years | 
| bicarbonate blood level | metabolic acidosis, metabolic alcalosis | Through study completion, an average of 2 years | 
| Heamoglobin | Anemia | Through study completion, an average of 2 years | 
| platelets level | thrombocytemia | Through study completion, an average of 2 years | 
| Urine output | Polyruria above 3 L/day | Through study completion, an average of 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Acute kidney injury, Hantavirus infection, Hantavirus nephropathy