Outcome After Dental Implant Treatment

Study Overview
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Brief Summary
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The general aim of this project is to investigate the long-term treatment outcome after implant therapy. The patients' satisfaction with implant treatment will be studied and correlated to biological and technical problems. The survival rates of implants at patient level and the degree of bone loss of remaining teeth and implants will be calculated. The levels of cytokines and bone loss markers in peri-implantitis sites and periodontal defects and at healthy sites will be analyzed in order to study the correlation between cytokine and bone loss marker levels, and clinical conditions. Independent variables which could be regarded as significant risk factors or risk predictors on the incidence of peri-implantitis are aimed to be identified

Detailed Description
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A questionnaire study will investigate patient satisfaction 8-14 years after dental implant therapy to study if complications influence the degree of satisfaction/quality of life. The questionnaire will be sent to 587 patients treated at The Specialist Clinic Skanstull. A clinical examination of a minimum 150 patients who answered the questionnaire will be performed: to study the incidence of biological and technical complications on dental implants after a minimum of 10 year of function. to study the survival rates of implants at patient level and the degree of bone loss of remaining teeth and implants. In addition, the correlation between bone loss of remaining teeth and bone loss of implants will be studied. samples taken from the gingival crevicular fluid to investigate the profile of cytokines and bone resorption markers as well as to study the intra-individual correlation of cytokines and bone markers in gingival crevicular fluid from sites with peri-implantitis and periodontal defects in individuals with dental implants. in addition, the salivary cytokine and bone resorption markers will be analyzed in order to identify disease-specific biomarkers as well as to study the correlation between the cytokine/bone resorption markers in saliva and in gingival/peri-implant crevicular fluid. To identify significant risk factors or risk predictors on the incidence of peri-implantitis.

Official Title
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Longterm Outcome After Dental Implant Treatment

Conditions
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PROMs, Peri-implantitis, Mucositis, Periodontitis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Treated at the Specialist Clinic Skanstull, Stockholm, Sweden with dental implants between the years of 1999-2005 Exclusion Criteria: - Deceased before or during the study period

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patients satisfaction after dental implant treatment | Questionnaire and clinical examination | 10 years after implant treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complications prevalence | Self reported and registered in patients journal and detected at the clinical examination | 10 years after implant treatment | 
| Profile of inflamatory markers | Samples of saliva and gingival fluid from healthy and disease sites at both tooth and dental implants will be analyzed | 10 years after implant treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dental implant, patient satisfaction, treatment outcome, cytokine profile, risk factor, risk predictor