linjc16/ctgov huggingface dataset:
Effect of Heart Rate on Left Ventricular Performance

Study Overview
=================
Brief Summary
-----------------
The current study is aimed at determining the normal response to increasing heart rates. For this purpose, atrial pacing will be used to increase heart rate.

Detailed Description
-----------------
Participants will be patients with pacemakers and normal A-V node conduction with a possibility for right atrial pacing mode. Detailed Echo studies will be performed at baseline. Echo studies will be repeated at each pacing stage, stages defined as 10 bpm increments in paced heart rate. Each stage will last 2-3 min or as long as it takes to record the echo study. Heart rate will be increased to 85% of predicted heart rate for age or at to appearance of signs of ischemia. Hemodynamic parameters will be recorded and segmental longitudinal strain will be calculated (as well as other Echo data), for each stage.

Official Title
-----------------
Effect of Heart Rate on Left Ventricular Performance

Conditions
-----------------
Myocardial Function, Myocardial Strain

Intervention / Treatment
-----------------
* Procedure: Increase in paced heart rate


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with AAI or DDD pacemaker with intact AV nodal conduction that can be set to work in AAI mode. Stable rhythm (either sinus or paced). Good quality baseline echo. Able and willing to sign Informed Consent Form. Exclusion Criteria: Prior heart failure or ischemic heart disease. Severe valvular lesions. Severe pulmonary hypertension. Known intolerance to rapid pacing. Multiple extrasystoles (more than 1 per echo or monitor screen). Age over 70.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Increase in paced heart rate|The pacing rate will be increased by 10 bps at every stage|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Segmental Strain | Segmental Strain by speckle tracking method will be calculated for every stage of each study. | approx. 20 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| LV function | Parameters of systolic and diastolic function will be calculated at each stage. | Approx. 20 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Strain, Ejection fraction, Diastolic function
Effects of Ritalin on Postural Stability of Old Adults

Study Overview
=================
Brief Summary
-----------------
Experimental design overview The proposed project is a prospective experimental study design. independent old adults(age 65 years old and older) who do not suffer from balance problems willing to participate in the study will be tested with well-established measuring techniques of Balance control before and 2 hours after taking of Methylphenidate (Ritalin) in the movement and Rehabilitation Laboratory at BGU. An automated algorithm will be used to extract standardized stabilogram-diffusion parameters from each of the COP data sets collected during quiet standing. These parameters include diffusion coefficients, critical displacement, critical time and scaling exponents for both lateral and anterior-posterior sway directions (Collins & De Luca, 1993). For each of the conditions (before and 1 hour after the use of Ritalin) in three task conditions single task; dual task (concentrating and identifying specific music); and just Listening to a relaxing music. Participants will be required to stand on the platform 10 times for 30 s. For each trial, they will be instructed to sway as little as possible.

Official Title
-----------------
Effects of Methylphenidate on Postural Stability of Old Adults Under Single and Dual Task Conditions.

Conditions
-----------------
Postural Imbalance

Intervention / Treatment
-----------------
* Drug: Methylphenidate


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 65 years old and older independent elderly adults do not suffer from balance prblems minimental score 24 and above Exclusion Criteria: old adults who suffer from neurological disease or stroke old adults who suffer from psychiatric state old adults who suffer from orthopedic condition (1/2 a year after a fracture in the lower limb) old adults who suffer from heart conditions old adults who suffer from blindness

Ages Eligible for Study
-----------------
Minimum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Methylphenidate<br> | Drug: Methylphenidate<br>* The effect of ritalin on postural stability of old adults (65 years old and over) will be measured using RCT study design<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postural sway measures |  | Time 1: pre test' and hour later time 2: post testinng proceedure | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Dual tasking, Postural Control, Methylphenidate (Ritalin), old adults
Thromboelastography (TEG) Reference Range Study

Study Overview
=================
Brief Summary
-----------------
As part of a system wide reagent verification plan Haemoscope Corporation will be running a study to verify the reference intervals of many of the reagents. Reference intervals will be constructed following the guidelines set out in CLSI document C28-A3c. This guideline calls for a reference interval to be constructed from at least 120 donors. Some reagents currently have ranges in place based on fewer donors than that stated in the guideline. This procedure will provide additional testing results to meet the requirements outlined in the CLSI guideline. Reagents that currently have no reference intervals will be tested and will include a minimum of 146 donors.

Official Title
-----------------
Procedure for the Reference Range Study for Haemoscope Reagents

Conditions
-----------------
Coagulation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male or Female over the age of 18 years. Exclusion Criteria: Genetic bleeding disorders Currently Pregnant Oral Contraceptives On anti-coagulants or anti-platelet therapy Took ASA (Acetylsalicylic Acid)within 1 week prior Recent surgery (within 4 weeks) Recent injury leading to substantial bruising (within 2 weeks)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy Volunteers<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
TEG, Thromboelastography, Coagulation
Smartphone-based Stress Management Intervention for Employees

Study Overview
=================
Brief Summary
-----------------
Participants were able to use the application the investigators developed for four weeks. With the application, the participants were able to monitor their stress level and life style patterns. The participants were also provided personalized stress management techniques including psychoeducation and cognitive behavioral technique. In 2014, additional relaxation techniques-abdominal breathing, progressive muscular relaxation, and meditation-were incorporated. Participants' mental health status and life style patterns were evaluated at baseline and at 4 weeks. Pre- and post-intervention statuses were compared after adjusting for degrees of life stress factors. Brief encounter psychosocial instrument (BEPSI-K) score and Center for Epidemiologic Studies Depression Scale (CES-D) score were used as primary outcome measures.

Official Title
-----------------
Development of Stress Guide for Employees: Smartphone-based Stress Management Intervention

Conditions
-----------------
Stress, Psychological

Intervention / Treatment
-----------------
* Behavioral: Stress guide


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Any employee from three corporations (the Korea Gas Corporation (KOGAS), the Korea District Heating Corporation (KDHC), and the Korea Expressway Corporation (KEC)); any individual who visited the health promotion center for a health checkup at Seoul National University Bundang Hospital Exclusion Criteria: None

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Interventional Model Description: Healthy individuals recruited through advertisement
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: treatment arm<br>All individual is instructed to use the application we developed for 4 weeks | Behavioral: Stress guide<br>* smartphone-based application that can evaluate stress level and teach how to manage their stress<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline Center for Epidemiologic Studies Depression Scale (CES-D) score at 4 weeks | Change from baseline Center for Epidemiologic Studies Depression Scale (CES-D) score at 4 weeks | Baseline and after the intervention for 4 weeks | 
| Change from baseline Brief encounter psychosocial instrument (BEPSI-K) score at 4 weeks | Change from baseline Brief encounter psychosocial instrument (BEPSI-K) score at 4 weeks | Baseline and after the intervention for 4 weeks |
Accuracy of Pulse Oximeters With Profound Hypoxia

Study Overview
=================
Brief Summary
-----------------
This study to assess the oxygen saturation accuracy of the Beddr SleepTuner in profound hypoxia.

Official Title
-----------------
Accuracy of Pulse Oximeters With Profound Hypoxia

Conditions
-----------------
Oximetry

Intervention / Treatment
-----------------
* Device: Oximeter


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The subject is male or female, aged ≥18 and <50. The subject is in good general health with no evidence of any medical problems. The subject is fluent in both written and spoken English. The subject has provided informed consent and is willing to comply with the study procedures. Exclusion Criteria: The subject is obese (BMI>30). The subject has a known history of heart disease, lung disease, kidney or liver disease. Diagnosis of asthma, sleep apnea, or use of CPAP. Subject has diabetes. Subject has a clotting disorder. The subject a hemoglobinopathy or history of anemia, per subject report or the first bloodsample, that in the opinion of the investigator, would make them unsuitable for study participation. The subject has any other serious systemic illness. The subject is a current smoker. Any injury, deformity, or abnormality at the sensor sites that in the opinion of the investigators' would interfere with the sensors working correctly. The subject has a history of fainting or vasovagal response. The subject has a history of sensitivity to local anesthesia. The subject has a diagnosis of Raynaud's disease. The subject has unacceptable collateral circulation based on exam by the investigator (Allen's test). The subject is pregnant, lactating or trying to get pregnant. The subject is unable or unwilling to provide informed consent, or is unable or unwilling to comply with study procedures. The subject has any other condition, which in the opinion of the investigators' would make them unsuitable for the study.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy Adult Volunteer<br> | Device: Oximeter<br>* Participants breathe a controlled gas mixture to induce several reduced oxygen states while oximeter measurements are taken for comparison to corresponding arterial blood draw samples to assess oximeter accuracy.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| SpO2 Accuracy | Collect and analyze data to determine SpO2 accuracy of oximeters under test. | 60 minutes |
Cervical Length in Cases of Placenta Previa

Study Overview
=================
Brief Summary
-----------------
This study establishes the relationship between cervical length and whether it can be used to predict haemorrhage and preterm delivery in cases of placenta previa.

Detailed Description
-----------------
Some studies have reported an association between ultrasonographic decreased cervical length and the likelihood of complications as antepartum or post-partum haemorrhage requiring an emergency caesarean section (CS) . The safety of trans-vaginal scanning is not in doubt, and the technique now has widespread acceptance. As a consequence, the clinical presentation of placenta previa has changed and most low lying placentas are diagnosed during the second trimester anomaly scan. The objective of this study was to establish if there is a relation between transvaginal ultrasonographic measurement of cervical length in cases of placenta previa and whether it can be used as a predictor for antepartum haemorrhage or not.

Official Title
-----------------
Value of Third Trimester Cervical Length Measurement in Predicting Risk and Severity if Antepartum Haemorrhage in Cases of Placenta Previa

Conditions
-----------------
Placenta Previa

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age: 20-45 years old Single Pregnancy Fetal gestational age 28 to < 36 weeks Normal amniotic fluid index (AFI) Diagnosis of placenta previa by pelvic ultrasound that was confirmed when the lower placental edge overlies the internal cervical os on transvaginal ultrasound (TVS). Exclusion Criteria: Threatened preterm labor and maternal use of vaginal progesterone. Preterm premature rupture of membranes; Polyhydramnios; Presence of cercelage and history of cervical cone biopsy which both affect cervical length. Diagnosis of multiple fetal anomalies; Women with other risk factors for intra-partum hemorrhage

Ages Eligible for Study
-----------------
Minimum Age: 25 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cervical length measured in mm in relation to antepartum haemorrhage | To find out the relationship between cervical length measured by transvaginal ultrasound and occurrence of antepartum hemorrhage in cases of placenta previa. | 4 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Need for blood transfusion | Yes or no and no.of packed units | 4 months | 
| Need for caesarean hysterectomy | Yes or no | 4 months | 
| Type of cesarean delivery | Elective or emergency cesarean delivery | 4 months | 
| Need for neonatal ICU | Yes or no | 4 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Placenta previa, Cervical length, Antepartum haemorrhage
Pulse Oximeter Screening in Congenital Heart Disease

Study Overview
=================
Brief Summary
-----------------
Pulse oximetry screening of newborn infants increases early detection of critical congenital heart disease and minimises the risk of circulatory collapse before surgery. This study provides an update on the implementation of pulse oximetry screening in Turkey

Detailed Description
-----------------
The early detection of life-threatening, critical congenital heart defects in newborn babies still presents an important clinical challenge. Most defects are amenable to intervention but timely diagnosis (ie, before presentation with cardiovascular collapse or death) is crucial. In high-income countries, examination and, increasingly, antenatal ultrasound have formed the basis of screening, but test accuracy of these procedures is variable and many babies with critical congenital heart defects are discharged before diagnosis. Pulse oximetry screening of newborn infants increases early detection of critical congenital heart disease and minimises the risk of circulatory collapse before surgery. This study provides an update on the implementation of pulse oximetry screening in Turkey

Official Title
-----------------
Pulse Oximeter Screening for Critical Congenital Heart Disease in Newborns

Conditions
-----------------
Congenital Heart Disease

Intervention / Treatment
-----------------
* Other: Prospective screening study


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Babies within the first 24-72 hours followed up in well baby nurseries Babies prior to discharge, if discharged before 24 hours of age, Babies ≤5 days and still followed up in well baby nurseries Babies born ≥35 gestational weeks Exclusion Criteria: Babies within the first 12 hours of life Babies >5 days of life Babies with a gestational age of >35 weeks Babies with major congenital anomaly except congenial heart disease Babies who had a prenatal diagnosis of congenital heart disease

Ages Eligible for Study
-----------------
Minimum Age: 1 Day
Maximum Age: 5 Days

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Prospective screening study|Prospective screening study in newborns|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pulse oximeter positivity | Congenital heart disease detection by pulse oximeter | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| echocardiographic confirmation | echocardiographic confirmation of congenital heart disease | 12 months |
Registry of Acute Coronary Syndromes in the Lazio Region of Italy

Study Overview
=================
Brief Summary
-----------------
The NET-SCA Registry has been designed to document and evaluate the clinical epidemiology and current management of Acute Coronary Syndromes in the Lazio Region of Italy.

Detailed Description
-----------------
Lazio is a region of central Italy with a resident population of about 5,600,000. The NET-SCA Registry has been designed to document and evaluate the current presentation and clinical management of Acute Coronary Syndromes (ACS) in this specific regional area of Italy. All consecutive patients with ACS admitted to CCU of 15 hospitals of the Lazio Region will be included in the registry.

Official Title
-----------------
First Prospective Observational Registry of the Lazio Regional Network for Acute Coronary Syndromes

Conditions
-----------------
Acute Coronary Syndromes

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: admission to CCU for ACS Exclusion Criteria: ACS due to major extracardiac causes (i.e. traumatic)
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total Mortality |  | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiovascular Mortality |  | 12 months | 
| New admissions of ACS |  | 12 months | 
| New admissions for heart failure |  | 12 months | 
| New admissions for coronary revascularization |  | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Acute Coronary Syndrome