A Study to Evaluate the Safety and Efficacy of ASP015K in Moderate to Severe Rheumatoid Arthritis

Study Overview
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Brief Summary
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The purpose of this study is to evaluate the safety and efficacy of ASP015K in moderate to severe rheumatoid arthritis (RA) subjects

Detailed Description
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Subjects will take ASP015K or matching placebo orally with food for 12 weeks after randomization. Potential subjects who have previously used disease-modifying antirheumatic drugs (DMARDs) and/or biologic agents may be eligible to participate after completing a washout period. Subjects who complete the 12-week dosing period in this study may be eligible to participate in a long-term, open-label Extension Study.

Official Title
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A Phase 2b, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Dose-Finding, Multi-Center Study to Evaluate the Safety and Efficacy of ASP015K in Moderate to Severe Rheumatoid Arthritis Patients

Conditions
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Arthritis, Rheumatoid

Intervention / Treatment
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* Drug: peficitinib
* Drug: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ≥ 6 tender/painful joints; ≥ 6 swollen joints C-Reactive Protein (CRP) of ≥ 0.8 mg/dL or Erythrocyte Sedimentation Rate (ESR) of ≥ 28 mm/hr Subject meets the ACR 1991 Revised Criteria for Global Functional Status in RA Class I, II or III at Screening and Baseline Use of non-steroidal anti-inflammatory drugs [NSAIDs], cyclooxygenase-2 (COX-2) inhibitors, or oral corticosteroids for the treatment of RA must be stable for at least 28 days prior to start of the study Male and female subjects must be willing to comply with contraception requirements as well as restrictions regarding egg and sperm donation Female subject must not be breastfeeding at Screening or during the study period, and for 60 days after the final study drug administration Subject agrees not to participate in another interventional study while on treatment Exclusion Criteria: Positive Mycobacterium tuberculosis (TB) test within 90 days of Screening Abnormal chest x-ray indicative of an acute or chronic infectious process or malignancy Receipt of live or live attenuated virus vaccination within 30 days prior to the first dose of study drug Known history of positive test for hepatitis B surface antigen (HBsAg) or hepatitis C antibody or history of a positive test for human immunodeficiency virus (HIV) infection History of any other autoimmune rheumatic disease, other than Sjogren's syndrome Previous history of clinically significant infections or illness (requiring hospitalization or requiring parenteral therapy) within 90 days of the Baseline visit, or a history of any illness that would preclude participation in the study History of any malignancy, except for successfully treated basal or squamous cell carcinoma of the skin or in-situ carcinoma of the cervix. Does not meet specified washout criteria for the following RA medications: gold, azathioprine, minocycline, penicillamine, etanercept, certolizumab, adalimumab, golimumab, infliximab, cyclophosphamide, and leflunomide Previous intolerance to Janus kinase (JAK) inhibitors Receipt of intra-articular or parenteral corticosteroid within 28 days prior to the first dose of study drug or is currently taking > 30 mg oral morphine (or narcotic equivalent) per day Receipt of plasma exchange therapy within 60 days prior to the start of study drug Receipt of any investigational agent within 30 days or 5 half-lives, whichever is longer, prior to first dose of study drug Receipt of medications that are CYP3A substrates with narrow therapeutic range within 14 days prior to first dose of study drug History of heart failure, defined as New York Heart Association (NYHA) grade 3 or greater History of long QT syndrome or prolonged QT interval Any ongoing severe, progressive, or uncontrolled renal, hepatic, hematological, gastrointestinal, metabolic, endocrine, pulmonary, cardiac, neurological, or infectious disease, or any ongoing illness which would make the subject unsuitable for the study Subject has any condition possibly affecting oral absorption (e.g., gastrectomy, other malabsorption syndromes, or clinically significant diabetic gastroenteropathy)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: ASP015K lowest dose<br>ASP015K lowest dose once daily | Drug: peficitinib<br>* oral<br>* Other names: ASP015K;|
| Experimental: ASP015K low dose<br>ASP015K low dose once daily | Drug: peficitinib<br>* oral<br>* Other names: ASP015K;|
| Experimental: ASP015K medium dose<br>ASP015K medium dose once daily | Drug: peficitinib<br>* oral<br>* Other names: ASP015K;|
| Experimental: ASP015K high dose<br>ASP015K high dose once daily | Drug: peficitinib<br>* oral<br>* Other names: ASP015K;|
| Placebo Comparator: Placebo<br>Matching placebo once daily | Drug: Placebo<br>* oral<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of subjects achieving American College of Rheumatology Criteria 20 (ACR 20) response |  | Week 12 | 
| Trough plasma concentration of ASP015K and metabolite(s) |  | up to Week 12 (6 time points) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of subjects achieving ACR 50 response |  | Week 12 | 
| Percentage of subjects achieving ACR 70 response |  | Week 12 | 
| Change from baseline in Disease Activity Score using 28 joint count and C Reactive Protein (DAS28-CRP) |  | Baseline and Week 12 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Rheumatoid Arthritis, ASP015K