AS-OCT of the Cornea in Thyroid Diseases

Study Overview
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Brief Summary
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use the anterior segment optical coherence tomography (AS-OCT) to evaluate the tear meniscus parameters, total corneal thickness (CT), and epithelial thickness in active and inactive thyroid eye diseases (TED) patients and compare them with age-matched controls.

Detailed Description
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A prospective case-control clinical study. The study subjects were divided into 3 groups, group 1 of inactive thyroid patients, group 2 of active thyroid patients, and group 3 of healthy controls. The AS-OCT was used to measure lower tear meniscus parameters (tear meniscus height (TMH), tear meniscus depth (TMD), and tear meniscus area (TMA)), total CT and epithelial thickness

Official Title
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Anterior Segment Optical Coherence Tomography Study of the Tear Film and Cornea in Thyroid Eye Diseases.

Conditions
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Thyroid Eye Disease

Intervention / Treatment
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* Diagnostic Test: AS-OCT


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The inclusion criteria were patients with thyroid disorders with age between 20 to 60 years with no ocular manifestations Exclusion Criteria: being younger than 20 or older than 60, presence of systemic diseases as diabetes mellitus (DM) and autoimmune diseases as rheumatoid arthritis (RA) that may cause dry eye, previous ocular surgery, use of contact lenses, smokers, pregnant women, and breastfeeding women.
Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| group 1<br>70 eyes of 35 patients of thyroid inactive disease | Diagnostic Test: AS-OCT<br>* Optical Coherence Tomography (OCT) creates detailed cross-sectional images of the anterior and posterior segments using low coherence interferometry. OCT is a noninvasive, real-time method for evaluating the tear meniscus, total corneal thickness (CT), and corneal epithelial thickness<br>|
| Group 2<br>70 eyes of 35 patients of thyroid active disease | Diagnostic Test: AS-OCT<br>* Optical Coherence Tomography (OCT) creates detailed cross-sectional images of the anterior and posterior segments using low coherence interferometry. OCT is a noninvasive, real-time method for evaluating the tear meniscus, total corneal thickness (CT), and corneal epithelial thickness<br>|
| Group 3<br>Healthy controls | Diagnostic Test: AS-OCT<br>* Optical Coherence Tomography (OCT) creates detailed cross-sectional images of the anterior and posterior segments using low coherence interferometry. OCT is a noninvasive, real-time method for evaluating the tear meniscus, total corneal thickness (CT), and corneal epithelial thickness<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tear Meniscus Height | represented by a line joining the points corresponding to the upper corneo-meniscus junction to the lower eyelid-meniscus junction | through study completion, an average of 6 months | 
| Tear Meniscus Depth (TMD): | represented as the distance between the center of the upper boundary of the tear meniscus and the point at the bottom boundary where the cornea meets the eyelid | through study completion, an average of 6 months | 
| Tear Meniscus Area (TMA) | triangular area formed by the corneal anterior boundary, anterior boundary of the lower eyelid and anterior borderline of the tear meniscus | through study completion, an average of 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cornea- Tear film- AS-OCT