Non-invasive Measurement of Central Hemodynamics by Electrical Impedance Tomography

Study Overview
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Brief Summary
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The purpose of this study is to evaluate the ability to measure central hemodynamics and heart-lung interactions non-invasively by electrical impedance tomography and compare it to clinically established hemodynamic monitoring.

Detailed Description
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The purpose of this study is to evaluate the ability to measure central hemodynamics and heart-lung interactions non-invasively by electrical impedance tomography and compare it to clinically established hemodynamic monitoring.

Official Title
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Non-invasive Measurement of Central Hemodynamics and Heart-lung Interactions by Electrical Impedance Tomography

Conditions
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Comparison of Availability for Prediction of Volume Responsiveness, Comparison of Limits of Agreement for Invasive and Non-invasive Measurement of Stroke Volume Variation

Intervention / Treatment
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* Other: volume loading


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age >18 years Indication for advanced invasive hemodynamic monitoring due to operative procedure Necessity of postoperative invasive ventilation Exclusion Criteria: Age <18 years known affections cardiac function presence of cardiac arrhythmias contraindication for placement of central venous or femoral artery catheter

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: study group<br>comparison of ability to predict volume responsiveness and precision of measurement of stroke volume variation assessed by electrical impedance tomography in comparison to clinically established invasive hemodynamic monitoring devices, i.e. arterial pulse contour analysis during volume loading procedures | Other: volume loading<br>* volume loading according to functional parameters of cardiac preload, i.e. stroke volume variations measured by arterial pulse contour analysis<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ability to assess volume responsiveness by electrical impedance tomography | Assessment of volume responsiveness by electrical impedance tomography in mechanically ventilated patients by measurement of stroke volume variations under stepwise volume loading | within 3 hrs after surgical procedure | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| precision of estimation of non invasive measurement of stroke volume variation | precision of estimation of non invasive measurement of stroke volume variation by electrical impedance tomography in comparison to clinically established, invasive advanced hemodynamic monitoring devices | within 3 hours after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hemodynamic monitoring, volume responsiveness, electrical impedance tomography