Effects of Desflurane and Propofol During Lung Volume Reduction Surgery

Study Overview
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Brief Summary
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Patients presenting for lung volume reduction are very high risk patients and it is important they receive the best anesthetic available. This study aims to answer which is the best anesthetic for managing such cases.

Detailed Description
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The anesthetic technique for lung volume reduction surgery consists of a thoracic epidural in combination with a general anesthetic. The thoracic epidural is routine for this operation and allows administration of local anesthetics and painkillers in the epidural space which results in profound pain relief in the area of surgery. The epidural is routinely used for pain control during the surgery and after the surgery when the patient is awake. The general anesthetic used may be a volatile agent (gas for example Desflurane), which is administered through the anesthesia machine, or an intravenous anesthetic agent, which is administered into a vein through an intravenous line as a continuous infusion (example Propofol). The use of an anesthetic agent and an epidural often causes a decrease in blood pressure which is treated with medication. The investigators are comparing the two anesthetic techniques regarding their effect on blood pressure and the amount of medication needed to treat it.

Official Title
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A Comparison of the Anesthetic and Hemodynamic Effects of a Volatile Anesthetic (Desflurane) and an Intravenous Anesthetic (Propofol), During Lung Volume Reduction Surgery

Conditions
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Lung Volume Reduction Surgery

Intervention / Treatment
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* Drug: Propofol
* Drug: Desflurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Scheduled to undergo lung volume reduction surgery (LVRS) Exclusion Criteria: Does not sign a study consent form

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Patients were randomized to receive propofol or desflurane as the maintenance anesthetic.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Propofol<br>Patients will receive Propofol as an intravenous (IV) agent, which is administered into a vein through an IV line as a continuous infusion. | Drug: Propofol<br>* Intravenous administration<br>* Other names: Diprivan;|
| Active Comparator: Desflurane<br>Patients will receive Desflurane as a gas that is administered through an anesthesia machine. | Drug: Desflurane<br>* Volatile administration<br>* Other names: Suprane;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time of discontinuation of anesthetic to eye opening | Measured in minutes | Up to 30 minutes (during procedure) | 
| Time of discontinuation of anesthetic to tidal volume (TV) 300ml | Measured in minutes | Up to 30 minutes (during procedure) | 
| Time of discontinuation of anesthetic to extubation | Measured in minutes | Up to 30 minutes (during procedure) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of intensive care unit (ICU) stay | Measured in days | Up to 1 month from procedure | 
| Duration of hospital stay | Measured in days | Up to 1 month from procedure | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Anesthesia