Focused TTE for Hemodynamic Instable High Risk Patients

Study Overview
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Brief Summary
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Focused transthoracic echocardiography (TTE) is a technique, which allows quick and non-invasive diagnosis and monitoring in hemodynamic instable patients. There are preliminary data supporting the hypothesis that TTE is feasible in the operating theatre. The purpose of this study is to test the hypothesis that intraoperative focused TTE has an impact on high risk patients´ management when it is added to standard extended monitoring practices in hemodynamic instabilities.

Detailed Description
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Focused TTE is en emerging matter in anesthesia, intensive care and emergency medicine. The value of intraoperative TTE is unclear. There are preliminary data that it is feasible For intraoperative transesophageal echocardiography (TEE) an impact on cardiac and non-cardiac surgery patients´ management has been shown. Purpose of this study is to evaluate the application of focused TTE in patients with increased perioperative risk undergoing moderate to high risk surgery who become hemodynamic instable during anesthesia in the operating theatre. When hemodynamic instability under anesthesia occurs focused TTE is conducted and the obtained diagnostic information are used for further patient management. Any change in management or therapy will be recorded.

Official Title
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Intraoperative Focused TTE - Impact on High Risk Patients´ Management in Hemodynamic Instabilities

Conditions
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Hemodynamic Instability During Anesthesia, High Risk Surgery

Intervention / Treatment
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* Other: intraoperative TTE


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: gender: male, female Age ≥ 18 years increased perioperative risk, at least one of the following: coronary artery disease congestive heart disease insulin dependent diabetes mellitus renal insufficiency, creatinine > 2,0 mg/dl cerebrovascular disease Sepsis Procedure with at least moderate increased risk intraperitoneal surgery intrathoracal surgery major orthopedic/traumatologic surgery prostatic surgery vascular surgery Hemodynamic instability, at least one of the following: Hypotension (systolic blood pressure < 80 mmHg or mean blood pressure <50 mmHg) and/or Bradycardia < 45/min. orr Tachycardia > 120/min and/or Cardiac index < 2,0 l/min/m2 Exclusion Criteria: cardiac surgery

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: intraoperative TTE<br>TTE if a hemodynamic instability occurs | Other: intraoperative TTE<br> <br> * Other names: intraoperative transthoracic echocardiography;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of patients´ management | Recordings of TTE findings influencing change of patient´s management in the operating theatre | at time of anesthesia / surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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focused TTE, intraoperative TTE, transthoracic echocardiography, high risk non-cardiac surgery, hemodynamic instabilities