linjc16/ctgov huggingface dataset:
Effects of a Hypoglycemia Protocol With Glucose Gel on Neonatal Intensive Care Unit (NICU) Admission

Study Overview
=================
Brief Summary
-----------------
Evaluate if the implementation of a hypoglycemia protocol with glucose gel has reduced the NICU admission rate of neonates with low-acuity neonatal hypoglycemia.

Official Title
-----------------
A Retrospective Analysis of the Effects of a Hypoglycemia Protocol With Glucose Gel on NICU Admission

Conditions
-----------------
Hypoglycemia, Neonatal Hypoglycemia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All neonates born at Banner University Hospital during January 01, 2014 - November 30, 2016 and January 01, 2018 - November 30 2018 who qualify for hypoglycemia protocol. Exclusion Criteria: Neonates <34 weeks gestational age or with birth weight less than 2000 grams. Infants with serious congenital malformation Infants with a terminal disorder.

Ages Eligible for Study
-----------------
Minimum Age: 34 Weeks

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pre implementation of hypoglycemia protocol with glucose gel<br>All neonates born at Banner University Hospital during January 01, 2014 - November 30, 2016 who qualify for hypoglycemia protocol | |
| Post implementation of hypoglycemia protocol with glucose gel<br>All neonates born at Banner University Hospital during January 01, 2018 - November 30 2018 who qualify for hypoglycemia protocol | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean NICU length of stay rounded to the day | Mean NICU length of stay rounded to the day | 30 days | 
| Mean maximum glucose infusion rate | Mean maximum glucose infusion rate | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assess for complications | - Number of neonates identified to have any type of infection | 30 days | 
| Assess for weight loss | - Maximum weight loss as percent below birth weight during NICU admission | 30 days | 
| Evaluate for persistent symptomatic or asymptomatic hypoglycemia | Number of neonates with symptomatic hypoglycemia Number of neonates with asymptomatic hypoglycemia | 30 days | 
| Number of neonates who received formula | Time to gain back to birthweight (if occurred while in-house), rounded to day of life | 30 days | 
| Number of neonates with any breastfeeding during hospitalization | Time to gain back to birthweight (if occurred while in-house), rounded to day of life | 30 days | 
| Number of neonates with breastfeeding at time of discharge | Time to gain back to birthweight (if occurred while in-house), rounded to day of life | 30 days |
Obstetric Complications in Women Who Smoke During Pregnancy

Study Overview
=================
Brief Summary
-----------------
This will be a retrospective study. Details on all women who delivered in McGill University between 2001-2007 will be retrieved anonymously from the MOND database (McGill University Obstetrics and Neonatal database). Women will be divided to 2 groups according to their smoking status in pregnancy. Obstetric complications will be recorded in both groups.

Detailed Description
-----------------
This will be a retrospective study using the McGill University Obstetrics and Neonatal database (MOND). This is a comprehensive database the contains details on all women delivering in McGill University Health Center in Montreal Canada. Details on all women who delivered in McGill University between 2001-2007 will be retrieved anonymously from the MOND database (McGill University Obstetrics and Neonatal database). Women will be divided to 2 groups according to their smoking status in pregnancy. Obstetric complications will be recorded in both groups. Statistic tests would be applied in order to assess relation between smoking and Obstetrical complications.

Official Title
-----------------
Obstetric Complications in Women Who Smoke During Pregnancy

Conditions
-----------------
Smoking

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria:all All women who delivered in McGill University health center between 2001-2008 Exclusion Criteria: delivery prior to 24 weeks (data on <24 weeks not included in the database..)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Non smokers<br>Women who did not report smoking in pregnancy | |
| Smokers in pregnancy<br>Women who report smoking in pregnancy | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neonatal Intensive Care Unit admission rate in women who smoke in pregnancy | Using the MOND database We will assess NICU admission rate of babies to women who smoke | pregnancy 40 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Birthweight | we will assess birth weight of babies to mothers who smoke Vs those who don't | 40 weeks of pregnancy | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
smoking, pregnancy
Establishment of Acute Lymphocytic Leukemia Data Base in the Department of Oncology

Study Overview
=================
Brief Summary
-----------------
Establishment of Acute Lymphocytic Leukemia Data Base in the Department of Oncology

Detailed Description
-----------------
Establishment of Acute Lymphocytic Leukemia Data Base in the Department of Oncology

Official Title
-----------------
Establishment of Acute Lymphocytic Leukemia Data Base in the Department of Oncology

Conditions
-----------------
Acute Lymphocytic Leukemia

Intervention / Treatment
-----------------
* Other: Database


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with diagnosed Acute Lymphocytic Leukemia Exclusion Criteria: Patients with diagnosis other than Acute Lymphocytic Leukemia

Ages Eligible for Study
-----------------
Minimum Age: 14 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Database|Database|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Acute Lymphocytic Leukemia
Comparison of Efficacy of Ivabradine Versus Metoprolol

Study Overview
=================
Brief Summary
-----------------
Ivabradine may be better than Metoprolol for controlling heart rate before Coronary CTA.

Official Title
-----------------
Comparison of Efficacy and Safety of Ivabradine Versus Metoprolol for Controlling Heart Rate Prior to 640-Slice Computed Tomographic Angiography in Elective Patients

Conditions
-----------------
Coronary Artery Disease

Intervention / Treatment
-----------------
* Drug: Ivabradine and Metoprolol


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: elective patient on scheduled for 640 slices CT coronary at Phramonkutklao hospital Resting heart rate > 70 BPM age > 18 years and informed consent Exclusion Criteria: Heart rate > 100 BPM BP <100/60 mmHg recent congestive heart failure in 1 mo. SA node, AV node disease and AF on permanent pacemaker CrCL < 15ml/min. , AST or ALT > 3x UNL on HR reducing drug such as diltiazem, verapamil, digitalis contraindication for ivabradine or metoprolol

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Ivabradine<br>Patients will recieved ivabradine(5) 1 tab bid pc for 3 day and the day of CT, and recieve placebo of metoprolol | Drug: Ivabradine and Metoprolol<br> <br> |
| Active Comparator: metoprolol<br>Metoprolol (100) 1/2 tab bid pc for 3 day and the day of CT coronary , and placebo of ivabradine | Drug: Ivabradine and Metoprolol<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart rate of patient before CT coronary |  | 1 January 2013 to 31 december 2013 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| safety and side effect of Metoprolol and Ivabradine |  | 1 january 2013 to 31 december 2013 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
CT coronary, Coronary arterial disease, ivabradine, metoprolol
Radiographic Findings and Their Temporal Changes in COVID-19 Positive Changes Patients: A Prospective Study

Study Overview
=================
Brief Summary
-----------------
All Patient irrespective of age with confirmed COVID-19 admitted to hospital and who underwent chest radiograph will be enrolled in the study to find raduigraphic findings and their temporal changes in COVID-19.

Detailed Description
-----------------
In this prospective trial the investigator will work on radiology findings and their temporal changes in COVID-19 positive patients and who underwent chest radiograph will be enrolled in our study. Patient selection will be consecutive in addition of age , gender and comorbid conditions clinical information will included travel,expose and contact history. All patients should be positive for COVID-19 via laboratory testing with real time reverse transcriptase polymerase chain reaction(rRT-PCR) In addition, the number of rRT-PCR tests performed on each patient, on which test a positive result was found,and the number of days between symptomology onset and date of first positive test will be recorded. In view of the current dynamics, any other reliable diagnostic test(s) if added to the clinical protocol will also be considered for inclusion in this study. Tabulation of radiographic findings for all consecutive X-rays will be done along with the temporal changes of these findings. further, the clinical findings with the outcomes(duration of hospital findings, ventilatory support and discharge/death).

Official Title
-----------------
Radiographic Findings and Their Temporal Changes in COVID-19 Positive Changes Patients: A Prospective Study

Conditions
-----------------
COVID

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1.Patients confirmed positive for COVID-19 by rRT-PCR irrespective of age. Exclusion Criteria: 1.Patients with flu like symptoms but negative for COVID-19 by rRT-PCR.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Radiographic findings and their temporal changes in COVID-19 positive patient: A Prospective study | Determine the radiographic findings in chest X-ray of COVID-19 positive patients. | 1-2 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Radiographic findings and their temporal changes in COVID-19 positive patient: A Prospective study | Correlation of clinical findings with the outcomes (duration of hospital stay, ventilatory support, and discharge/death) | 4-8 weeks |
Short Term Corticosteroids in SARS-CoV2 Patients

Study Overview
=================
Brief Summary
-----------------
The investigators reviewed the charts of SARS-CoV-2 patients with pneumonia and moderate to severely elevated CRP and worsening hypoxemia who were treated with early, short-term dexamethasone.

Official Title
-----------------
The Effect of the Short-term Use of Systemic Corticosteroids in COVID-19 Patients in Regard to Hospital Length of Stay, Morbidly and/or Mortality.

Conditions
-----------------
Corticosteroids, Covid19, SARS-CoV 2, Steroids, Dexamethasone

Intervention / Treatment
-----------------
* Drug: Dexamethasone


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Moderate disease with at least a 30% increase in CRP within 36 hours of admission, and with increasing oxygen requirements. All patients with severe disease with evidence of escalating oxygen requirements The presence of secondary bacterial infections as a probable cause of increasing CRP levels was excluded in all selected patients. Pulmonary embolism and /or cardiac dysfunction were excluded as probable causes of worsening hypoxia in all selected patients. Exclusion Criteria: All patients on other treatment modalities- Remdesivir and/or Convalescent plasma who showed evidence of clinical improvement as per decrease in CRP levels and/or oxygen requirements were excluded. Patient with associated COPD exacerbation who would benefit from the use of steroids. Patients with Diabetic ketoacidosis, hyperglycemic hyperosmolar state, active concurrent bacterial infections. Patients with history of steroid-induced mania and/or psychosis.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| SARS-CoV2 patients that received dexamethasone<br> | Drug: Dexamethasone<br>* 4mg dexamethasone was given to some patients three times daily for 2 days, 2 times daily for 2 days, once daily for 2 days.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect on transfers to ICU and escalation of care needing mechanical ventilation |  | 2 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect on length of stay |  | 2 months | 
| Change in CRP levels |  | 2 months |
Multimodal Intervention in Allogeneic Stem Cell Transplantation

Study Overview
=================
Brief Summary
-----------------
Objective: To evaluate the feasibility and safety of a 4-6 weeks exercise - psycho-educational intervention in patients undergoing allogeneic stem cell transplantation (allo-HCST). The intervention included structured and supervised exercise, relaxation and psycho-educational components. It was hypothesized that the intervention would minimize loss of physical capacity during hospitalization.

Official Title
-----------------
Pilot Study of an Exercise an Psycho-Educational Intervention During Allogeneic Stem Cell Transplantation

Conditions
-----------------
Allogeneic Stem Cell Transplantation, Leukemia

Intervention / Treatment
-----------------
* Behavioral: Multimodal exercise and psychosocial program


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18-65 yrs patients undergoing allogeneic stem cell transplantation Exclusion Criteria: recent cardiovascular or pulmonary disease abnormal EKG psychiatric disorder motor function, musculoskeletal or neurological disturbances bony metastasis

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Multimodal exercise and psychosocial program|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physical capacity VO2 max, muscle strength (1RM, Isometric), stair test |  | Baseline, post | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| quality of life indices |  | baseline, post, 3 and 6 months | 
| FACT-An, EORTC, HADS, Mini-Mac, Symptom Assessment form |  | baseline, post, 3 and 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Patients undergoing allogeneic stem cell transplantations
Characterization and Differential Diagnosis of Vertebral Osteomyelitis

Study Overview
=================
Brief Summary
-----------------
Vertebral osteomyelitis is a uncommon disease that can lead to neurologic deficits if not diagnosed in time. The etiologies of vertebral osteomyelitis include pyogenic bacteria, M. tuberculosis, Brucella species, and fungus. The aim of this study is to describe the clinical features and microbiological/radiological characteristics of patients with vertebral osteomyelitis, and investigate the useful tips for the differential diagnosis of vertebral osteomyelitis.

Detailed Description
-----------------
Besides description of characteristics of patients with vertebral osteomyelitis, we also will investigate the usefulness of 16S rRNA gene sequence analysis of biopsy specimen. MRI findings during the antibiotic treatment will be monitored and compared for the differential diagnosis of meningitis.

Official Title
-----------------
Clinical Features, Microbiological-, Radiological Characteristics, and Differential Diagnosis of Vertebral Osteomyelitis

Conditions
-----------------
Vertebral Osteomyelitis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Symptoms or signs consistent with spinal column infection MRI findings suggestive of infection Antibiotic treatment for vertebral myelitis Exclusion Criteria: Patients already treated more than 2 weeks for osteomyelitis in transferring hospital

Ages Eligible for Study
-----------------
Minimum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Spondylitis<br>Patients who checked spine MRI for back pain | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Identification of etiology of vertebral osteomyelitis |  | within 6 weeks after the diagnosis of vertebral osteomyelitis | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Unfavorable outcomes (death or permanent neurologic deficit) |  | within 6 months after the diagnosis of vertebral osteomyelitis | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
osteomyelitis, 16S rRNA, spine, Magnetic resonance imaging
Evaluation of Mental Flexibility Through Language Tests in Adolescents With Frontal Brain Damage and in Healthy Children in Ages 8-17

Study Overview
=================
Brief Summary
-----------------
This study aims to shed light on the theoretical concept of mental flexibility and its manifestation in adolescents following frontal lobe damage, and to develop a test battery for young Hebrew speakers.

Conditions
-----------------
Persons With Frontal Lobe Damage With no Specific Language Disorder

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: frontal lobe damage at least one year after injury native hebrew speaker Exclusion Criteria: specific language disorder premorbid learning disability

Ages Eligible for Study
-----------------
Minimum Age: 8 Years
Maximum Age: 17 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Anxiety and / or Depressive Disorders in a Population of French Airline Pilot

Study Overview
=================
Brief Summary
-----------------
Throughout their career, the medical abilities of airline pilots are regularly assessed. This population is exposed to occupational constraints and risks, in particular psychosocial, and could constitute a population at risk of developing anxiety and/or depressive disorders. However, mental health remains difficult to apprehend in this population because of a strong stigmatization of mental disorders and the risk of loss of medical certification to fly. In the literature, there are very few studies dealing with mental disorders in airline pilots and the results are heterogeneous, with a prevalence of anxiety and/or depressive disorders ranging from 1.9 to 12.6%. There is no study of this type among airline pilots employed in France. Therefore it seems useful to determine the prevalence of anxiety and/or depressive disorders in this population and to describe the co-factors associated with these disorders.

Official Title
-----------------
Descriptive Study of Anxiety and/or Depressive Disorders in a Population of Airline Pilots Employed in France and Unionized at the SNPL

Conditions
-----------------
Anxiety Disorders, Depressive Disorder

Intervention / Treatment
-----------------
* Behavioral: Survey


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Airline pilot, employed in France and unionized at the Syndicat National des Pilote de Ligne (SNPL) Exclusion Criteria: None

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Survey|Survey is proposed to all pilots who are members of the National Union of Airline Pilots|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Depressive and anxiety disorders | Anxiety and depressive disorders as measured by Hospital Anxiety and Depression Scale (HAD-S). The HADS consists of 14 items, seven items indicating anxiety and seven items indicating depression. The answer format offers four options, scored with values from 0 to 3. This results in scale values between 0 and 21 for each scale. Three ranges were defined by the original test authors: 0-7 (non-cases), 8-10 (doubtful cases), and 11-21 (cases) | at baseline |