Normotensive and Hypertensive Placental Abruptions

Study Overview
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Brief Summary
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Placental abruption is a significant cause of both maternal morbidity and neonatal morbidity and mortality. Most abruptions accept to be related to a chronic placental disease process. Therefore, it is very important to understand these processes. To analyze maternal and neonatal effects of placental abruption(PA) through a novel classification in the presence of hypertension. Initial hemoglobin parameters were also compared to predict pregnancy outcomes in addition to hypertension.

Detailed Description
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Objective: We aimed to classify placental abruption according to hypertension status. Methods: This retrospective cohort designed study was conducted on 115 pregnant women with placental abruption. The main parameters scanned and recorded from the hospital database and patient medical files. Two groups were classified regarding of presence or absence of hypertension (53 hypertensive, 62 normotensive). Maternal demographical and clinical characteristics (abdominal pain, vaginal bleeding) were recorded. APGAR scores below 5 at 1 and 5 min., fetal or neonatal death, admission and length of stay in Neonatal Intensive Care Unit(NICU) were also investigated and compared between the groups.

Official Title
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Comparison of Maternal Neonatal Outcomes of Normotensive and Hypertensive Placental Abruptions: A Novel Approach

Conditions
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Abruptio Placentae; Affecting Fetus or Newborn

Intervention / Treatment
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* Other: clinical assesment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: spontaneous, singleton pregnancies above 25 weeks of gestations with positive fetal cardiac activity Exclusion Criteria: multiple gestations, presence of fetal or maternal infection, chronic inflammatory diseases or connective tissue disorders history of myocardial infarction, thrombosis history of steroid drug usage.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1 (with hypertension )<br>Two groups were classified regarding of presence or absence of hypertension (53 hypertensive, 62 normotensive). | Other: clinical assesment<br>* Comparison of Hypertensive group and normotensive group<br>|
| Group 2( without hypertension)<br>Two groups were classified regarding of presence or absence of hypertension (53 hypertensive, 62 normotensive). | Other: clinical assesment<br>* Comparison of Hypertensive group and normotensive group<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| blood pressure measurement | mm Hg | 2 minute | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hemogram parameters WBC(white blood cell) ,PLT(Platelet), MPV(mean platelet volume), HGB(hemoglobin), Neutrophil lymphocyte ratio..) | complete blood test retrospective complete blood count analysis | first 1 hour | 
| maternal and newborn length, weight | centimeters,kilogram | 5 minute | 
| APGAR score | 1st and 5th minute newborn assesment | 5 minute | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Abruptio placenta, complete blood count, hypertension, perinatal outcome., mean platelet volume