Retinal and Choroidal Microvascular Changes During Pregnancy Period Detected With Optical Coherence Tomography Angiography

Study Overview
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Brief Summary
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During pregnancy many physiological changes and adaptations occur.Hormonal, hematological and hemodynamic changes are responsible for most of the ocular adaptations.We are planning to compare the choroid and retinal blood flow values and choroidal thickness of pregnant women and healthy non pregnant women with optical coherence tomography and optic coherence tomography angiography

Detailed Description
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During pregnancy many physiological changes and adaptations occur such as pulmonary, renal, endocrinological, haematological and visual system changes are happening. In previous studies, retinal and choroidal pregnancy-related changes in blood flow and choroidal thickness have been demonstrated. Optical coherence tomography angiography (OCTA) detects the contrast of motion in the blood flow, detecting the capillary of the retina and choroid. It is a new functional method that visualizes the retinal networks and outer retina without using dyes.It is a non-invasive method that provides volumetric angiography information. In this study evaluation of the variability of choroidal and retinal blood flow changes and choroidal thickness, between trimesters of pregnancy and the non-pregnant control group is planned. Choroid and Retinal Blood Flow Values and Choroidal thickness in 41 pregnant women in the first trimester and it would be repeated at second and third trimesters. We compare measured values between trimesters and 45 healthy non-pregnant women.

Official Title
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Evaluation of Retinal and Choroidal Microvascular Structures: Comparison With Three Trimesters of Healthy Pregnant Women and Healthy Non-pregnant Women Using Optical Coherence Tomography Angiography

Conditions
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Pregnancy Related

Intervention / Treatment
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* Diagnostic Test: Optical Coherence Tomography,Optical Coherence Tomography Angiography(Topcon)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy pregnant women Age > 18 years Exclusion Criteria: Systemical disease such as diabetes mellitus or hypertension Refractive error; spherical equivalence > 4 diopters Ocular disease or surgery history

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pregnant Women<br>Healty pregnant women between 18-45 years,with no history of eye surgery and systemical disease.In 1st , 2nd and 3rd trimesters the measurements will be repeated | Diagnostic Test: Optical Coherence Tomography,Optical Coherence Tomography Angiography(Topcon)<br>* Optical coherence tomography optical coherence tomography angiography<br>* Other names: Blood Pressure Measurement;|
| Control Group<br>Healty non-pregnant women between 18-45 years with no history of eye surgery and systemical disease. | Diagnostic Test: Optical Coherence Tomography,Optical Coherence Tomography Angiography(Topcon)<br>* Optical coherence tomography optical coherence tomography angiography<br>* Other names: Blood Pressure Measurement;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Choroidal thickness | Choroidal thickness is measured by optical coherence tomography | 40 weeks | 
| Retinal thickness | Retinal thickness is measured by optical coherence tomography | 40 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Foveal avascular zone(FAZ) area measurement | FAZ area is measured by optical coherence tomography anjiography | 40 weeks | 
| Retinal vascular density | % of retinal vascular density is measured by optical coherence tomography angiography | 40 weeks | 
| Retinal nerve fiber layer thickness | Retinal nerve fiber layer thickness (um) is measured by optical coherence tomography | 40 weeks | 
| Ganglion cell layer measurement | Ganglion cell layer measurement is measured by optical coherence tomography | 40 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pregnancy, Tomography, Optical Coherence, Choroid, retina