Evaluation of an Arterial Calcification Score as a Predictive Factor of Anastomotic Leakage in Right Colectomy

Study Overview
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Brief Summary
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Anastomotic leakage is the major postoperative complication in right colectomy. Evaluation of calcification on coeliac trunk and mesenteric arteries on the preoperative CT scan could allow the identification of patient at-risk of postoperative complications. A monocentric retrospective study performed at CHD Vendée concluded than a calcification score over or equal to 3 was associated with a higher risk of developping an anastomotic leakage. The aim of this prospective multicentric study is to validate a calcification score based on preoperative CT scan analysis and focussing at coeliac trunk and mesenteric arteries.This study will involve patients operated on with a scheduled right colectomy.

Official Title
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Evaluation of an Arterial Calcification Score as a Predictive Factor of Anastomotic Leakage in Right Colectomy

Conditions
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Right Colectomy

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥ 18 years old Scheduled right colectomy with restoration of digestive continuity Patient who has had or will have a preoperative abdominal-pelvic CT scan with or without contrast injection Patient with the ability to understand the protocol and agree to participate in the study. Affiliated with a social security system Exclusion Criteria: Patient requiring a right colectomy or ileocaecal resection for chronic inflammatory bowel disease or on long-term corticosteroid therapy Patient with a history of colic resection Patient under guardianship, curatorship, or deprived of liberty Pregnant, postpartum or breastfeeding women Minor patients

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Right colectomy<br>Patient with scheduled right colectomy and with a documented preoperative scan. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total calcification score associated with the occurrence of anastomotic leakage | Sum of the calcification scores of the following 4 segments (≥3) associated with the occurrence of anastomotic leakage within 6 weeks postoperatively. 4 segments: Ostium of celiac artery Ostium of superior mesenteric artery first segment of superior mesenteric artery distal segment of superior mesenteric artery Each segment will be assigned a score between 0 and 2. Total score range : 0-8 | 6 weeks after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Calcification score of each segment associated with the occurrence of anastomotic leakage | 4 segments: Ostium of celiac artery Ostium of superior mesenteric artery first segment of superior mesenteric artery distal segment of superior mesenteric artery Each segment will be assigned a score between 0 and 2. | 6 weeks after surgery | 
| Morbidities defined according to Clavien-Dindo classification | Morbidities defined according to Clavien-Dindo classification occurring at 6 weeks postoperatively | 6 weeks after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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right colectomy, calcification, anastomotic leakage