Prospective Follow-up, Marathon, Long Term, Inflammation and Cardiovascular System

Study Overview
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Brief Summary
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Pro-MagIC is a prospective observational study and includes participants of the Be-MaGIC-Study 2009 (n=277/NCT00933218). We aim to detect exercise-induced physiological changes (inter alia of the cardiovascular system) induced by repetitive ultra-endurance strain over a period of 10 years.

Detailed Description
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Physical activity is associated with health benefits. Acute prolonged and strenuous exercise, i.e. Marathon running, leads to hemodynamic, endothelial and myocardial functional changes. Whether these myocardial, endothelial and hemodynamic changes can also develop and persist through repetitive extreme and prolonged physical activity is currently still a matter of controversy. In addition, it is not known whether adaptations and changes over time can develop into clinically relevant cardiovascular events with negative health consequences in healthy athletes. The aim of this study is to detect exercise-induced physiological changes (inter alia of the cardiovascular system) induced by repetitive ultra-endurance strain over a period of 10 years. For this purpose, 277 male participants from the Be-MaGIC study (Marathon 2009) are examined in this prospective observational study. A single examination with the following components will take place: Anthropometry, clinical examination, laboratory, resting / exercise electrocardiography cardiopulmonary stress test, echocardiography, and fundus camera. Further examinations will be conducted in participants with abnormal examination results in line with current clinical recommendations.

Official Title
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Prospective Long Term Follow-up Analysis of Exercise-induced Physiological Changes in Male Runners

Conditions
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Participants of the Be-MaGIC-Study 2009

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Declaration of consent Participants must have participated in the Be-MaGIC study in 2009 current age: 30 - 70 years sex: male Exclusion Criteria: -

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of right ventricular systolic function (RV-EF) | Echocardiography | 10 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in left ventricular ejection fraction (LV-EF) | Echocardiography | 10 years | 
| Changes in left ventricular diastolic function (E/e´) | Echocardiography | 10 years | 
| Change in cardiac markers (e.g. cardiac Troponin) | Clinical chemistry (blood samples) | 10 years | 
| Change in inflammation markers (e.g. C-reactive Protein) | Clinical chemistry (blood samples) | 10 years | 
| Change in microcirculation (e.g. arteriolar-to-venular ratio) | Static Retinal Vessel Analyzer | 10 years | 
| Change in macrocirculation (e.g. Intima media thickness) | Carotid sonography | 10 years | 
| Change of prevalence of cardiovascular diseases | Questionnaire | 10 years | 
| Association between changes of aforementioned parameters (see Topics 1-8) and potential underlying causes (e.g. sports history like number of ultraendurance competitions) in the examined cohort |  | 10 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Prolonged exercise, marathon, cardiovascular disease, long term