Assessing Muscle Metabolic Phenotype by MSK Ultrasound

Study Overview
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Brief Summary
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The purpose of this study is to test whether ultrasound images (pictures) can be used as a valid assessment of muscle quality in different muscle groups during Intensive Care stay. This new approach would allow clinicians to obtain frequent skeletal muscle images and would enable doctors to observe any changes over time in muscle quality that could occur during ICU stay. Participants in this study will have ultrasound images made of their leg-, chest- and jaw muscles taken on every day until ICU discharge.

Official Title
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Assessment of Muscle Metabolic Phenotype by the Use of Point-of-care MSK Ultrasound Imaging.

Conditions
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Ultrasound, CT, MuscleSound

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: admission Duke Trauma center, SICU, MICU, or CT ICU >18 years of age Exclusion Criteria: <18 years of age prisoners

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Duke ICU/Trauma Center Patients<br>Any patient admitted to the Duke Trauma Center or Duke ICU will be approached to participate in this study. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle Quality from the rectus femoris, vastus lateralis, intermedius, intercostalis, temporalis and styloglossus | Ultrasound-derived area of intramuscular adipose tissue (IMAT) and intramuscular glycogen content from the rectus femoris, vastus lateralis, intermedius, intercostalis, temporalis and styloglossus | Minimum of every other day while in ICU (up to 10 days). Once discharged from ICU minimum of 3x a week until discharge (up to 3 weeks) | 
| Muscle volume and thickness from the rectus femoris, vastus lateralis, intermedius, intercostalis, temporalis and styloglossus | Ultrasound-derived volume and thicknessfrom the rectus femoris, vastus lateralis, intermedius, intercostalis, temporalis and styloglossus | Minimum of every other day while in ICU (up to 10 days). Once discharged from ICU minimum of 3x a week until discharge (up to 3 weeks) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of Intramuscular adipose tissue (IMAT) content and muscle volume/thickness from the psoas at the Level of L3/L4 | the change over time of (standard of care) CT-derived area of intramuscular adipose tissue in cm2 | Up to 1 year | 
| Changes of Intramuscular adipose tissue (IMAT) content and muscle volume/thickness from the intercostal muscle at the Level of Th3/Th4 | the change over time of (standard of care) CT-derived area of intramuscular adipose tissue in cm2 | Up to 1 year | 
| Changes of Intramuscular adipose tissue (IMAT) content and muscle volume/thickness from the intercostal muscle at the Level of the head | the change over time of (standard of care) CT-derived area of intramuscular adipose tissue in cm2 | Up to 1 year |