Use of a Novel Neuroplasticity-based Neurobehavioral Intervention for PTSD

Study Overview
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Brief Summary
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The present study will explore the effectiveness of a computer based neurobehavioral intervention in alleviating symptoms and improving emotion regulation in individuals with PTSD. It will increase understanding of psychopathology at a neural-circuit level and aid development of new non-pharmacological treatment for PTSD. The study is managed by the Etkin Lab at Stanford University in California, but participants from the entire US are welcome to participate as the study is delivered online.

Official Title
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Use of a Novel Neuroplasticity-based Neurobehavioral Intervention for PTSD - A Nationwide, Online Study

Conditions
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Anxiety, Depression

Intervention / Treatment
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* Behavioral: Computerized Neurobehavioral Intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: current PTSD internet access Exclusion Criteria: lifetime psychotic disorder, past-year substance dependence

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Engaging in Computerized tasks<br>Participants will log into a personalized website and engage in computerized tasks online. | Behavioral: Computerized Neurobehavioral Intervention<br>* Targeted, computerized interventions completed from the participants' own home on a computer.<br>|
| Experimental: Neurobehavioral computerized tasks<br>Participants will log into a personalized website and engage in computerized tasks online. | Behavioral: Computerized Neurobehavioral Intervention<br>* Targeted, computerized interventions completed from the participants' own home on a computer.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| WebNeuro Computerized Cognitive and Affective Assessment Battery | Age and gender-normed Z scores for the following measures: Sustained attention accuracy, Sustained attention lapses, Sustained attention false alarms, Working memory capacity, Visual scanning speed, Inhibition executive control, Processing speed, Maze completion executive control accuracy, Maze completion executive control speed, Immediate verbal memory, Delayed verbal memory, Inhibitory motor control accuracy, Inhibitory motor control lapses, Facial affect identification accuracy (happy, fearful, angry, sad, and disgusted), Facial affect identification speed (happy, angry, fearful, sad, or disgusted), Facial affect identity recognition accuracy (happy, angry, sad, fearful, or disgusted), Facial affect identity recognition speed (happy, sad, angry, fearful, or disgusted), Emotional conflict reaction time slowdown, Regulation of emotional conflict reaction time slowdown | Baseline and 3-month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinician-assessed PTSD symptoms | Total and symptom sub scale scores from the Clinician-Administered PTSD Scale for DSM-IV (CAPS) | Baseline and 3-month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Computerized neurobehavioral intervention