COVID-19 - SARS-CoV-2 Community Contamination in Children and Adults (Dyn3CEA_Nosocor)

Study Overview
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Brief Summary
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Unlike other respiratory viruses such as influenza and Respiratory Syncytial Virus (RSV) where the child is the essential reservoir and central vector of intrafamilial contamination, the child is likely to be a small player in the transmission of Severe Acute Respiratory Syndrome CoronaVirus 2 (SRAS-CoV2) infection. This study aims to describe the age category of the first contact, within 14 days before the appearance of the first symptoms of the index case in order to describe the age categories of this first contaminant, globally, in the group of children and finally in the group of adults. This work is intended to provide food for discussion and to justify the distancing and containment measures imposed on children when their isolation has a deleterious impact that has now been established for some children.

Official Title
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Epidemiology of CoV-2 SARS Infections: Dynamics of Community Contamination in Children and Adults

Conditions
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Infection Viral

Intervention / Treatment
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* Other: Review of medical patient file
* Other: Phone call interview


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Children after hospitalized in Hospices Civils de Lyon with Polymerase Chain Reaction (PCR) positive SARS-CoV2, Adults hospitalized in Hospices Civils de Lyon and included in the NOSO-COR study with matching criteria described below. Matching will be performed on family age characteristics and on the period of contamination included in the containment period to minimize bias, and if possible frequency matching according to admission in Intensive Care Unit ICU/Pediatric Intensive Care Unit (PICU), and to family structure (n of children / n of adults in the family). Exclusion Criteria: Any patient suspected of nosocomial infection. Any patient death during the Covid-19 infection. Any adult patient without children living home. Opposition to participate.

Ages Eligible for Study
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Minimum Age: 0 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Children<br>Hospitalized children, 0 to 17 years of age, 25 subjects, consecutive sample survey | Other: Review of medical patient file<br>* Review of medical patient file, including patient tracing, brief summary of the disease course, barrier gestures, social distancing.<br>|
| Adults<br>Hospitalized adults, 18 years and above, 50 matched subjects | Other: Phone call interview<br>* less than 15 minutes phone call<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of possible contaminants, adults, adolescents and children with Covid-19 | To describe the age category of the 1st possible contaminant in the index case to show the preponderance of possible adult and adolescent contaminants in the SARS-Cov-2 contamination. Percentage of possible contaminants, adults, adolescents and children, in matched children and adults with Covid-19. | at inclusion |