Effect of Papaverine on Renal Artery Blood Flow Volume

Study Overview
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Brief Summary
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The purpose of this study is to evaluate the effect of papaverine on renal artery blood flow after declamping of renal artery.

Detailed Description
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The purpose of this study is to evaluate the effect of papaverine on renal artery blood flow after declamping of renal artery in patients undergoing robot assisted partial nephrectomy.

Official Title
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Effect of Papaverine on Intraoperative Renal Artery Blood Flow Volume in Patients Undergoing Robot-assisted Partial Nephrectomy : a Randomized, Placebo-controlled Study

Conditions
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Kidney Cancer

Intervention / Treatment
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* Drug: Papaverine
* Drug: Normal saline


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients diagnosed with kidney cancer. Patients undergoing robot assisted partial nephrectomy under general anesthesia 20 years old ≤ age <80 years old Patients who voluntarily agreed to this clinical study eGFR ≥ 60 ml / min / 1.73 m2 (Chronic Kidney Disease Epidemiology Patients with Collaboration) Exclusion Criteria: The tumor ≥ 7 cm in size Multiple renal mass If the surgery plan is changed due to open When surgery is performed together with other surgery Multiple renal artery Patients with hypersensitivity to papaverine Patients with atrioventricular block Pregnant and lactating women Patients using levodopa Refusal of patient

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 79 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Papaverine group<br>Immediately after the renal artery declamping, papaverine 30 mg (1 ample, 1 ml) is mixed with 5 ml of normal saline (total 6 ml) and sprinkled around the renal artery. | Drug: Papaverine<br>* Immediately after the renal artery declamping, papaverine 30 mg (1 ample, 1 ml) is mixed with 5 ml of normal saline (total 6 ml) and sprinkled around the renal artery.<br>|
| Active Comparator: Normal saline group<br>Immediately after the renal artery declamping, normal saline 6 ml is sprinkled around the renal artery. | Drug: Normal saline<br>* Immediately after the renal artery declamping, normal saline 6 ml is sprinkled around the renal artery.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Renal artery blood flow | Renal artery blood flow 2 minutes after papaverine administration by doppler sonography | at 2 minutes after papaverine administration | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| estimated glomerular filtration rate | estimated glomerular filtration rate using KIDGO equation | at postoperative day 0 | 
| estimated glomerular filtration rate | estimated glomerular filtration rate using KIDGO equation | at postoperative day 1 | 
| estimated glomerular filtration rate | estimated glomerular filtration rate using KIDGO equation | at postoperative day 4 | 
| estimated glomerular filtration rate | estimated glomerular filtration rate using KIDGO equation | at postoperative day 14 | 
| estimated glomerular filtration rate | estimated glomerular filtration rate using KIDGO equation | at postoperative month 3 | 
| glomerular filtration rate using renal scan | glomerular filtration rate using renal scan | at postoperative month 3 |