Start Treatment and Recovery for Opioid Use Disorder

Study Overview
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Brief Summary
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The purpose of this study is 1) to evaluate whether emergency department-initiated medically assisted treatment with Buprenorphine/Naloxone in patients presenting with opioid use disorder will produce positive outcomes at 1 week, 3 months and 6 months after treatment initiation.

Detailed Description
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The emergency department is a critical missed opportunity to engage patients with opioid use disorder in medication-assisted treatment, the most effective current treatment for the disorder. Patients presenting at the emergency department with opioid use disorder will be given the opportunity to immediately start medication assisted treatment with Naloxone/Buprenorphine then referred either to a specialized addiction bridge clinic or a local waivered provider for further treatment.

Official Title
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Effectiveness of Bridge Clinic Following Emergency Department-Initiated Intervention for Opioid Use Disorder

Conditions
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Opioid-use Disorder, Mental Disorder, Opioid Medication Assisted Treatment

Intervention / Treatment
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* Other: Bridge Clinic


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient at Emergency Department Diagnosis opioid use disorder according to criteria Diagnostic and Statistical Manual (DSM) 5 Exclusion Criteria: Participating in alternate treatment program for opioid use disorder Prisoner Inability to communicate Psychosis Suicidality History of Buprenorphine injection Critical Illness

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Bridge Clinic<br>Medication assisted treatment supervised by addiction bridge clinic until stabilized in treatment. | Other: Bridge Clinic<br>* Specialized addiction bridge clinic<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants With Self-reported Treatment Retention | Self-reported enrollment in treatment for opioid use disorder after 1 week | 1 week | 
| Number of Participants With Self-reported Treatment Retention | Self-reported enrollment in treatment for opioid use disorder after 3 months | 3 months | 
| Number of Participants With Self-reported Treatment Retention | Self-reported enrollment in treatment for opioid use disorder after 6 months | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants With Illicit Opioid Use | Urine analyzed for opioids (buprenorphine, methadone, oxycodone, hydrocodone, hydromorphone, heroin, fentanyl) and other drugs (cocaine, amphetamines, benzodiazepines, cannabinoids) via enzyme multiplied immunoassay. Note buprenorphine and methadone positive results not treated as illicit. | 1 week | 
| Number of Participants With Illicit Opioid Use | Urine analyzed for opioids (buprenorphine, methadone, oxycodone, hydrocodone, hydromorphone, heroin, fentanyl) and other drugs (cocaine, amphetamines, benzodiazepines, cannabinoids) via enzyme multiplied immunoassay. Note buprenorphine and methadone positive results not treated as illicit. | 3 months | 
| Number of Participants With Illicit Opioid Use | Urine analyzed for opioids (buprenorphine, methadone, oxycodone, hydrocodone, hydromorphone, heroin, fentanyl) and other drugs (cocaine, amphetamines, benzodiazepines, cannabinoids) via enzyme multiplied immunoassay. Note buprenorphine and methadone positive results not treated as illicit. | 6 months |