Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure

Study Overview
=================
Brief Summary
-----------------
Premature ovarian failure (POF) is known to be associated with an increased risk of ocular surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen in this condition. From preliminary data, we suspect that women with Turners syndrome (45, XO), a genetic abnormality that affects sex hormone levels, are also at increased risk of ocular surface disease. Comparing POF and TS women may allow us to distinguish different mechanisms for ocular surface disease, due to the different etiologies of hormonal (estrogen and androgen) alterations posed by POF and TS.

Detailed Description
-----------------
Premature ovarian failure (POF) is known to be associated with an increased risk of ocular surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen in this condition. From preliminary data, we suspect that women with Turners syndrome (45, XO), a genetic abnormality that affects sex hormone levels, are also at increased risk of ocular surface disease. Comparing POF and TS women may allow us to distinguish different mechanisms for ocular surface disease, due to the different etiologies of hormonal (estrogen and androgen) alterations posed by POF and TS.

Official Title
-----------------
Ocular Impact of X Chromosome Karyotype and Sex Hormones in Turner Syndrome

Conditions
-----------------
Turner Syndrome, Ovarian Failure, Premature, Sex Chromosome Aberrations, Menopause, Perimenopause

Participation Criteria
=================
Eligibility Criteria
-----------------
INCLUSION CRITERIA: Ability to understand and give informed consent. Meet the diagnostic criteria for TS (45, X0) or premature ovarian failure OR age matched control for study participant with TS or POF. For non Turner syndrome subjects only - Negative pregnancy test or post menopausal status for greater than or equal to 1 year. Karyotype of XO for TS subjects or XX for POF and age matched control subjects. EXCLUSION CRITERIA: Persons less than 18 years old. Persons with ophthalmic diseases associated with ocular surface disease. Hyperprolactinemia. Cushing s syndrome. Other endocrine disorders which impact sex steroid hormones. AIDS Pregnancy or lactation. For age matched control population ONLY- complaints of dry eye. For age matched control population ONLY- oral contraceptives or menopausal hormone therapy or any medications which alter sex hormone levels in the blood or chronic usage of medications that induce dry eye.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Ocular Surface Disease, Imprinting, Eye Abnormalities, Ovarian Insufficiency, Women's Eye Health and Disease, Turner Syndrome, TS, Premature Ovarian Failure, POF, Healthy Volunteer, HV