Effect of Physical Activity Following Thoracic Mobilization on Heart Rate Variability and Pressure Pain Threshold.

Study Overview
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Brief Summary
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Comparison of the effects of physical activity (treadmill running) plus thoracic mobilization, physical activity only or a placebo intervention (only manual contact thoracic mobilization), on heart rate variability and pressure pain threshold.

Official Title
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Effect of Physical Activity Following Thoracic Mobilization on Heart Rate Variability and Pressure Pain Threshold in Asymptomatic Subjects: a Randomized Clinical Trial.

Conditions
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Healthy

Intervention / Treatment
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* Procedure: Physical activity plus thoracic mobilization
* Procedure: Physical activity
* Procedure: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Asymptomatic subjects Sedentary Exclusion Criteria: Spinal pain Historic of trauma/surgery to the spine Diabetes Hypo/hyperthyroidism Alcoholic Smoker Hypertension

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Physical activity plus thoracic mobilization<br>Subjects randomly allocated to this arm will be submitted to a 10 minutes anaerobic exercise (2 minutes warming up, 5 minutes of 75% to 85% maximal heat rate, 3 minutes slowdown), followed by 5 minutes of passive intervertebral thoracic mobilization (3 sets of 1 minute, grade III, and 1 minute rest between each set). | Procedure: Physical activity plus thoracic mobilization<br>* Information already included in arm/group descriptions.<br>|
| Active Comparator: Physical activity<br>Subjects allocated to this arm will be submitted to the same anaerobic exercise protocol, without the thoracic mobilization. | Procedure: Physical activity<br>* Information already included in arm/group descriptions.<br>|
| Placebo Comparator: Placebo<br>Subjects in this group will be conducted to a placebo thoracic mobilization, without anaerobic exercise protocol. The investigator will apply only a manual contact, to mimic the genuine thoracic mobilization. The same 5 minutes period will be respected, and the same position of therapist and subject. | Procedure: Placebo<br>* Information already included in arm/group descriptions.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart rate variability |  | Change from baseline, immediately after, and 15 minutes after the intervention. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pressure pain threshold | Digital algometer will be applied to C7 and T4 spinous process, right hand and right tibialis anterior muscle belly | Change from baseline, mimediately after, and 15 minutes after the intervention. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Asymptomatic individuals