Title: Comparison of Anti-plaque Efficacy of Natural Honey With Chlorhexidine Mouthwash: A Randomized Controlled Trial

Study Overview
=================
Brief Summary
-----------------
The rationale of our study is to compare the efficacy of natural honey base preparation with other commercially available mouthwashes i.e chlorhexidine base in prevention of dental plaque formation as honey is readily available and cost effective and organic in nature. This study will help to provide the data of our community and positive result may provide a new method of oral hygiene maintenance with fewer side effects. We will be able to deliver the best anti-plaque agent.

Detailed Description
-----------------
In this study, participants will assigned into 2 group those who will fulfilled the inclusion and exclusion criteria. After the informed consent, they were divided into 2 group. Group A will received Chlorhexidine mouthwash and Group B will provided with honey based mouthwash. The participant will blinded as solution will be provided in dark color bottle to mask the study. After which the baseline plaque index will be taken followed by recording plaque index on 7th, 14th, and 21st day. The statistical analysis will be done to compare the mean difference between these 2 groups

Official Title
-----------------
Comparison of Anti-plaque Efficacy of Natural Honey With Chlorhexidine Mouthwash: A Randomized Controlled Trial

Conditions
-----------------
Dental Plaque

Intervention / Treatment
-----------------
* Other: Natural honey
* Drug: Chlorhexidine mouthwash


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Individual aged between 18-25 Retained 28 number of teeth excluding wisdom teeth Exclusion Criteria: Individual with medical illness affecting oral cavity like diabetes, sjögren syndrome, crohn disease etc Multiple extraction , overhang restoration, wearing any appliance Periodontal problem with pocket depth more than 3mm Current or recent history of antibiotic consumption Noncompliance that is unable to maintain their hygiene. Pan, Betel quid and any other oral habit will not be included in study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 25 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: The participants divided into two groups. one group will received honey based oral rinses and other group received chlorhexidine mouthwash and will evaluate the reduction of dental plaque
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Chlorhexidine<br>these are the group which received chlorhexidine based preparation for plaque reduction | Drug: Chlorhexidine mouthwash<br>* Chlorhexidine gluconate 0.12% mouthwash is used as intervention in Group A (Arm Group A) for the comparison of plaque reduction among group A and B<br>* Other names: Chlorhexidine Gluconate;|
| Experimental: Natural honey<br>these group will received the honey base mouthwash and the its effect on plaque reduction will be observed in follow up visits | Other: Natural honey<br>* Natural Sidr honey based mouthwash used as intervention group B (Arm Group B) for the reduction of plaque index<br>* Other names: Sidr Honey;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dental Plaque | primary outcome is to assessed the reduction on plaque level among Group A and Group B | reduction of plaque index will be assessed on 7th day, 14th day and on 21st day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Dental plaque, Honey, Chlorhexidine