Effects of Panax Ginseng and Salvia Miltiorrhiza Supplementation on Vascular Function

Study Overview
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Brief Summary
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The purpose of is to determine the preventive effects of Chinese herb supplement with panax ginseng and salvia miltiorrhiza prior to eccentric resistance exercise on arterial stiffness and vascular reactivity by using a double-blind randomized control design and to examine the effects of a 12-week progressive eccentric resistance exercise training on arterial elasticity and vascular reactivity, and whether a long-term supplementation would ameliorate arterial stiffening effects elicited by exercise-induced inflammation and improve endothelial function.

Official Title
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Effects of Panax Ginseng and Salvia Miltiorrhiza Supplementation on Preventing Arterial Stiffening Effects Induced by Acute and Chronic Eccentric Exercise

Conditions
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Healthy

Intervention / Treatment
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* Behavioral: Eccentric exercise training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: -Healthy sedentary adults Exclusion Criteria: obesity (BMI >30 kg/m2) smoking within past six months hypertension (high blood pressure >140/90 mmHg) personal history of diabetes (fasting blood glucose >126 mg/dL), heart disease, or other cardiovascular problems orthopedic injury that may prevent him or her from completing the exercise the use of over-the-counter supplements or vitamins

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Herbs<br>participants assigned to experimental arm will take 300mg panax ginseng and 300mg salvia miltiorrhiza extracts in capsules for 12 weeks along with eccentric exercise training | Behavioral: Eccentric exercise training<br>* 12 weeks of lower leg eccentric training<br>|
| Placebo Comparator: Placebo<br>parcipants in this group will take placebo capsule containing microcrystalline cellulose | Behavioral: Eccentric exercise training<br>* 12 weeks of lower leg eccentric training<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pulse Wave Velocity | PWV will be measured before, 6th week, 12th week of eccentric exercise training. | Before eccentric exercise and training | 
| Pulse Wave Velocity | PWV will be measured before, 6th week, 12th week of eccentric exercise training. | 6th week of eccentric exercise traininig | 
| Pulse Wave Velocity | PWV will be measured before, 6th week, 12th week of eccentric exercise training. | 12th week of eccentric exercise training | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood pressure | Morning blood pressure will be measured before, during, and after 12 week of dietary and eccentric exercise intervention. | Before intervention | 
| Blood pressure | Morning blood pressure will be measured before, 6th, and after 12 week of dietary and eccentric exercise intervention. | 6th week of intervention | 
| Blood pressure | Morning blood pressure will be measured before, during, and after 12 week of dietary and eccentric exercise intervention. | 12th week of intervention |