Virtual Reality Exposure Therapy in the Intensive Treatment of Social Anxiety Disorder

Study Overview
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Brief Summary
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To explore the efficacy of drugs combined with virtual reality exposure therapy in the treatment of phobias compared with single drug treatment.

Official Title
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A Randomized Controlled Study of Virtual Reality Exposure Therapy in the Intensive Treatment of Social Anxiety Disorder

Conditions
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Phobia

Intervention / Treatment
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* Device: vert
* Drug: Sertraline


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Meet the diagnostic criteria for phobias in DSM-IV. Age from 18 to 45 years old. Graduated from junior high school or above. No serious physical disease, no serious visual impairment, and no family history of mental illness. Exclusion Criteria: Exclude other psychiatric diagnosis and treatment history.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: drug only<br>Sertraline was given as a single drug, with an initial dose of 50 mg/d, and gradually increased to the maximum dose of 200 mg/d after 2 weeks. The treating physician will determine the specific dose adjustment according to the patient's condition. | Drug: Sertraline<br>* Sertraline was given as a single drug, with an initial dose of 50 mg/d, and gradually increased to the maximum dose of 200 mg/d after 2 weeks. The treating physician will determine the specific dose adjustment according to the patient's condition.<br>|
| Experimental: vert combine with drug<br>On the basis of sertraline drug treatment, phobia patients were given 2d/times from the 5th week, each 35-45min VR exposure treatment, 15 times as a course of treatment. | Device: vert<br>* On the basis of sertraline drug treatment, phobia patients were given 2d/times from the 5th week, each 35-45min VR exposure treatment, 15 times as a course of treatment.<br>Drug: Sertraline<br>* Sertraline was given as a single drug, with an initial dose of 50 mg/d, and gradually increased to the maximum dose of 200 mg/d after 2 weeks. The treating physician will determine the specific dose adjustment according to the patient's condition.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the level of anxiety | the score of Hamilton anxiety scale, the minimum and maximum values are 0 and 56, and higher scores mean a worse outcome. | 3 months | 
| heart rate of the patients | take the heart rate as a biomarker of fear, the faster heart rate means the participate is more afraid | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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phobia, VR