Changes in Volumetric Hemodynamic Parameters Induced by Fluid Removal on Hemodialysis

Study Overview
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Brief Summary
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Changes in volumetric hemodynamic parameters and fluid overload (Cardiac Index,Stroke Volume, Thoracic Fluid Content, Systemic Vascular Resistance) were measured using a impedance cardiography (ICG) (CardioScreen 1000 - Haemodynamic Measurement System, Medis. GmbH Ilmenau) beginning 15 min prior to midweek dialysis session and continuous measurement thereafter, with a 15-min period after the termination of hemodialysis. Fluid overload were measured by BCM Monitor Fresenius before hemodialysis.

Official Title
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Changes in Volumetric Hemodynamic Parameters Induced by Fluid Removal on Hemodialysis

Conditions
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End Stage Renal Failure on Dialysis, Body Fluid Retention, Impedance, Cardiac Output, Low

Intervention / Treatment
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* Device: CardioScreen 1000 - Haemodynamic Measurement System, Medis
* Device: BCM- Body Composition Monitor, Fresenius Medical Care
* Device: SCHILLER, BR-102 plus, Ambulatory Blood Pressure Monitoring System


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: give voluntary consent to participate in the study patients on maintenance hemodialysis at least 3 months stable dry weight single-pool Kt/V >1.4 no clinical cardiovascular disease during the 6 months preceding entry Exclusion Criteria: not meet the above criteria episode of illness (for example: infection) pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hemodialysis patients<br>midweek dialysis session patients on maintenance hemodialysis at least 3 months stable dry weight single-pool Kt/V >1.4 no clinical cardiovascular disease during the 6 months preceding entry | Device: CardioScreen 1000 - Haemodynamic Measurement System, Medis<br>* Impedance cardiography (ICG)<br>Device: BCM- Body Composition Monitor, Fresenius Medical Care<br>* Information about the individual fluid status and the nutritional status.<br>Device: SCHILLER, BR-102 plus, Ambulatory Blood Pressure Monitoring System<br>* Blood pressure monitoring every 15 min during hemodialysis<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in volumetric hemodynamic parameter- cardiac index [l/min/m2]) induced by fluid removal on hemodialysis. |  | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in volumetric hemodynamic parameter- stroke volume [ml] induced by fluid removal on hemodialysis. |  | 1 day | 
| Changes in volumetric hemodynamic parameter- systemic vascular resistance [dyn·s·cm-5] induced by fluid removal on hemodialysis. |  | 1 day | 
| Changes in fluid removal parameter- thoracic fluid content [1/kOhm] during hemodialysis. |  | 1 day | 
| Changes in blood pressure values [mmHg] induced by fluid removal on hemodialysis. |  | 1 day |