linjc16/ctgov huggingface dataset:
Artificial Intelligence for Improved Echocardiography

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to assess the effect of artificial intelligence algorithms on image quality in echocardiography.

Detailed Description
-----------------
The study population will be recruited from appointed patients at the Clinic of Cardiology, St. Olavs Hospital. After being informed about the study, all patients giving informed consent and meeting the eligibility requirements will undergo their standard clinical echocardiographic exam performed by a sonographer at the clinic. Two additional examinations will then be performed by a different sonographer and an expert cardiologist, respectively. In one of the study arms the sonographer randomized to perform the second exam will use the AI algorithm (intervention).

Official Title
-----------------
Technology Revisiting Ultrasound Solutions of Tomorrow - Artificial Intelligence for Improved Echocardiography

Conditions
-----------------
Heart Diseases

Intervention / Treatment
-----------------
* Other: AI algorithm for apical foreshortening in echocardiography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Capacity to consent Exclusion Criteria: Indication for echocardiographic contrast agents

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: With AI algorithm<br>In the With AI algorithm arm, the sonographer will perform the echocardiographic exam using the AI algorithm. | Other: AI algorithm for apical foreshortening in echocardiography<br>* The algorithm is based on artificial intelligence, giving the sonographer performing the echocardiographic exam real-time feedback on left ventricular apical foreshortening.The algorithm is developed using deep learning techniques by technologists at the Department of Circulation and Medical Imaging, NTNU.<br>|
| No Intervention: Without AI algorithm<br>In the Without AI algorithm, the echocardiographic exam will be performed without the use of the AI algorithm. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Left ventricular apical foreshortening | Apical foreshortening will be evaluated in a blinded manner by echocardiography experts post hoc. The two study arms will be compared. | 0 days |
Effect of Anaesthesia on Basic Aminoacids

Study Overview
=================
Brief Summary
-----------------
Basic amino acids are acids that contains amino groups more than carboxylic groups. At least five basic amino acids namely; Arginine, citrulline, ornithine, lysine and hydroxylysine metabolize in our body. Loss of body protein represents a typical feature of the catabolic response to surgery.

Official Title
-----------------
Effect of Anaesthesia and Surgery on Plasma Levels of Nitric Oxide and Basic Aminoacids

Conditions
-----------------
Effect of Anaesthesia on Basic Aminoacids

Intervention / Treatment
-----------------
* Procedure: CABG


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: elective surgery ASA II,III Exclusion Criteria: Emergency surgery Associated renal or liver disease Chronic disease as D.M

Ages Eligible for Study
-----------------
Minimum Age: 55 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| coronary artery bypass<br> | Procedure: CABG<br>* aminoacids and NO levels<br>|
| thoracic surgery<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| basic aminoacids and NO levels |  | 72 hours |
Improvement of Accommodation With Anti-Oxidant Supplementation in Visual Display Terminal Users

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine the antioxidant supplementation effect on accommodation among visual display terminal (VDT) users.

Conditions
-----------------
Ocular Accommodation

Intervention / Treatment
-----------------
* Drug: CDR2


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: best corrected visual acuity is over 20/20 Exclusion Criteria: receiving any medication or supplement that would alter the accommodation status within a week from the commencement of this study using multifocal spectacles or contact lenses pregnant or lactating mothers subjects with a history of drug allergy

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 49 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: CDR2|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| accommodation changes |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Accommodation, visual display terminal (VDT), antioxidant
Changing Minds - Supporting Depressed Elderly People With an Individually Tailored Service Model

Study Overview
=================
Brief Summary
-----------------
Depression is one of the leading causes of emotional suffering in later life. It has been estimated that 2-5% of community-dwelling elderly people suffer from major depression, but according to recent studies, as much as 25 % have clinically significant depressive symptoms.Typically, depressive symptoms in the elderly are treated solely with antidepressants. The aim of this project is to study the effects of a comprehensive psychosocial intervention on the psychological well-being, quality of life and use of services in depressed elderly people. In addition, the processes of intervention are studied from the perspective of the participants as well as the service system. The research is conducted in collaboration with the city of Espoo. The design of the study combines clinical trial with qualitative process analysis.

Official Title
-----------------
Changing Minds - Studying the Effects of a Tailored Psychosocial Support Model on Depressive Mood and Quality of Life in Depressive Elderly People

Conditions
-----------------
Depression, Psychological Well-Being

Intervention / Treatment
-----------------
* Behavioral: Comprehensive psychosocial support for depressed elderly


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age 60+ Exclusion Criteria: severe memory disease

Ages Eligible for Study
-----------------
Minimum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Counseling<br> | Behavioral: Comprehensive psychosocial support for depressed elderly<br>* The model includes a psychiatric nurse as a care manager, a multiprofessional team with a physiotherapist, psychologist and psychiatrist. Each participant receives individually tailored services such as therapeutic groups, conversation groups, physical exercise, music therapy, art therapy and nutritional counseling<br>* Other names: Individually tailored support model for old age depression;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Alleviating depressive symptoms measured with Geriatric Depression Scale |  | base line, 6 months, 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of life measured with WHO QuolBref |  | base line, 6 months, 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Depression, Aging, Psychological well-being, Psychosocial intervention
Efficacy of Vitamin E in Preventing Contrast-Induced Acute Kidney Injury Following Coronary Angiography

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the effect of vitamin E on preventing from incidence of contrast induced acute kidney injury (CI-AKI) in the patients who undergone coronary angiography.

Conditions
-----------------
Post MI, Stable Angina, Unstable Angina, Non ST Segment Elevation Myocardial Infarction

Intervention / Treatment
-----------------
* Drug: Vitamin E


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients whon have either stable coronary artery disease (CAD) or recent acute coronary disease (ACS) and are scheduled for coronary angiography. Patients who have eGFR ≤60 ml/min/1.73 m2 Exclusion Criteria: Allergy to contrast media Cardiogenic shock Pulmonary edema Overt cardiac failure or left ventricular ejection fraction ≤ 30% Acute kidney injury The history of receiving contrast media for any medical diagnostic or therapeutic procedures during previous 5 days The history of dialysis Being pregnant Having recent acute myocardial infarction Taking antioxidants and nephrotoxic drugs including NSAID and ACE-I on previous 2 days

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo<br> | |
| Active Comparator: Vit-E<br>600 IU on 12 hours before angiography and 400 IU on 2 hours before angiography | Drug: Vitamin E<br> <br> * Other names: Alpha-tocopherol;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The development of CI-AKI in group receiving vitamin E compared with placebo |  | Within 72 hours after coronary angiography | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in the serum level of Cr and the amount of eGFR |  | Within 72 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Coronary angiography, Alpha-tocopherol, Vitamin E, Contrast-Induced Acute Kidney Injury
Role of Proteomics and Metallomics in Cerebral Vasospasm Following Subarachnoid Hemorrhage

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine the role of Proteomics and Metallomics in Cerebral Vasospasm following Subarachnoid Hemorrhage

Official Title
-----------------
Role of Proteomics and Metallomics in Cerebral Vasospasm Following Subarachnoid Hemorrhage

Conditions
-----------------
Subarachnoid Hemorrhage, Cerebral Vasospasm, Hydrocephalus

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Non traumatic SAH documented by CT scan Patient with SAH who would need external ventricular drain (EVD) for the management of hydrocephalus Patients with normal pressure Hydrocephalus that require an external drain Control (non - hemorrhagic) group - CSF collected from patients with posterior fossa tumor or stroke with EVD in place for the management of hydrocephalus. Exclusion Criteria: Recent infection within last 1 month of presentation- can increase inflammatory markers Recent surgery or acute myocardial infarction within last 1 month of presentation Age > 89 years or < 18 years

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 89 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| SAH Patients<br>Patients admitted with the diagnosis of aneurismal subarachnoid hemorrhage (SAH) and cerebral angiogram negative SAH who would need to have the external ventricular drain (EVD) placed for the management of hydrocephalus. | |
| Control Patients<br>Patients with non-hemorrhagic brain pathology such as posterior fossa tumor or stroke who will have the CSF sampling for diagnostic or therapeutic purposes. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Protein identification and concentration |  | For the duration of CSF drainage, or until the 21st day after admission. | 
| Metal ion identification and concentration |  | For the duration of CSF drainage, or until the 21st day after admission. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Xanthine Oxidase, Cerebrospinal fluid
Hyperpronation and Foot Pain

Study Overview
=================
Brief Summary
-----------------
Effects of training and pellots

Official Title
-----------------
Effect of Training and Pellots in Treatment of Foot Pain Caused by Hyperpronation

Conditions
-----------------
Arthritis of Knee

Intervention / Treatment
-----------------
* Procedure: training and pellots


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 110 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1<br>training and pellots | Procedure: training and pellots<br>* training and pellots<br>|
| No Intervention: 2<br>control | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Magnesium Treatment in Hypoparathyroidism

Study Overview
=================
Brief Summary
-----------------
Study hypothesis: supplementary magnesium may influence the blood calcium level in treated hypoparathyroid patients. Patients will be treated with supplementary magnesium (350 mg/day) for 3 weeks. Calcium and other relevant blood parameters will be measured before the treatment, at the end of treatment and 2 weeks after stopping treatment.

Official Title
-----------------
Effect of Magnesium Treatment on Plasma Calcium in Hypoparathyroid Patients

Conditions
-----------------
Hypoparathyroidism

Intervention / Treatment
-----------------
* Dietary Supplement: magnesium


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: primary or secondary hypoparathyroidism treatment with calcium plus vitamin D analogue ionized calcium 1,0-1,29 mmol/L magnesium level 0,7-1,05 mmol/L TSH 0.1- 10 imU/L Exclusion Criteria: any other disease known to influence plasma Ca level pregnancy creatinine > 150 microM/L patient has used supplementary magnesium within 2 previous months

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Dietary Supplement: magnesium|magnesium 350 mg tablets once a day for 3 weeks|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Calcium level at the end of magnesium treatment compared to pretreatment level |  | 3 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Calcium level after stopping treatment compared to the level at the end of magnesium treatment |  | 2 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
primary hypoparathyroidism, secondary hypoparathyroidism, magnesium
Medical Record Review of Hypohidrotic Ectodermal Dysplasia Clinical Phenotype

Study Overview
=================
Brief Summary
-----------------
This study is being done to collect information about people who have or may have Hypohidrotic Ectodermal Dysplasia (HED) or X-linked Hypohidrotic Ectodermal Dysplasia (XLHED). This study will allow Edimer Pharmaceuticals to know more about HED/XLHED so that hopefully the investigators can develop a drug to treat this condition. In this study Edimer will retrospectively review and abstract (summarize) medical records of people that have or may have HED/XLHED in order to further understand the natural history and disease characteristics.

Official Title
-----------------
Medical Record Review of Hypohidrotic Ectodermal Dysplasia Clinical Phenotype

Conditions
-----------------
Hypohidrotic Ectodermal Dysplasia, X-Linked Hypohidrotic Ectodermal Dysplasia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: -Males or females with: the clinical characteristics of HED, including at least two of the following characteristics: a history of decreased sweating;abnormal teeth (fewer permanent teeth, teeth are smaller than average and often have conical crowns);sparseness of scalp and body hair. -OR- genetically confirmed HED or XLHED;
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
HED, XLHED, X-linked Hypohidrotic Ectodermal Dysplasia (XLHED)
Improving Work Outcomes for Veterans With Traumatic Brain Injury

Study Overview
=================
Brief Summary
-----------------
The 12-month study will investigate a cognitive training augmentation of supported employment to improve cognitive performance and work outcomes, which are expected to result in improved quality of life and community integration for veterans with mild to moderate traumatic brain injuries. The primary hypothesis is that compared to veterans who receive enhanced supported employment, those who receive supported employment plus cognitive training will work more weeks during the 12 months.

Official Title
-----------------
Improving Work Outcomes for Veterans With Traumatic Brain Injury

Conditions
-----------------
Traumatic Brain Injury

Intervention / Treatment
-----------------
* Behavioral: Supported employment plus cognitive training
* Behavioral: Enhanced supported employment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: OEF/OIF veteran History of mild-to-moderate TBI (loss of consciousness <6 hours; post-traumatic amnesia <7 days) Documented impairment in at least one neuropsychological domain Unemployed, but stating a goal of work Written informed consent to participate in the study Exclusion Criteria: Current alcohol/substance abuse or dependence Participation in other intervention studies

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Supported employment for 12 months plus cognitive training for the first 12 weeks | Behavioral: Supported employment plus cognitive training<br>* Supported employment for 12 months plus cognitive training for the first 12 weeks<br>|
| Active Comparator: 2<br>Supported employment for 12 months plus one additional supported employment session per week for the first 12 weeks | Behavioral: Enhanced supported employment<br>* Supported employment for 12 months plus one additional supported employment session per week for the first 12 weeks.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Weeks worked |  | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hours worked |  | 12 months | 
| Dollars earned from working |  | 12 months | 
| Cognitive performance |  | 3, 6, and 12 months | 
| Neurobehavioral symptoms |  | 3, 6, and 12 months | 
| Quality of life |  | 3, 6, and 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
veterans, vocational rehabilitation, supported employment, cognitive training, cognitive remediation, cognitive rehabilitation