Proteomic Pattern Associated With the Diagnosis of Chronic Thromboembolic Pulmonary Hypertension

Study Overview
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Brief Summary
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Chronic ThromboEmbolic Pulmonary Hypertension (CTEPH) is a rare but severe complication of pulmonary embolism (PE). CTEPH is evoked in patients with persistent dyspnea. According to international guidelines, symptomatic patients with perfusion defects on lung scan and Pulmonary Hypertension (PH)-likely transthoracic echo (TTE) must be evaluated in Pulmonary Hypertension (PH)-centers with right heart catheterism, to confirm or rule out the presence of precapillary Pulmonary Hypertension (PH), and precise the group of Pulmonary Hypertension (PH).

Detailed Description
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However, persistent dyspnea and perfusion defects are frequent after pulmonary embolism (PE), and the accuracy of transthoracic echo (TTE) is not great for precapillary Pulmonary Hypertension (PH). This study proposed to seek for a specific proteomic pattern in patients admitted for a suspicion of Chronic ThromboEmbolic Pulmonary Hypertension (CTEPH).

Official Title
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Proteomic Pattern Associated With the Diagnosis of Chronic Thromboembolic Pulmonary Hypertension : PROTEO-CTEPH Study.

Conditions
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Chronic Thromboembolic Pulmonary Hypertension

Intervention / Treatment
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* Biological: blood sample


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient with a suspicion of Chronic thromboembolic pulmonary hypertension (CTEPH) with a combination of a perfusion lung scan and transthoracic perfusion scan and transthoracic echocardiography compatible with the diagnosis (according to French recommendations) Patients who require a right heart catheterization. Patient affiliated or entitled to a social security plan Patient having received informed information about the study informed about the study Exclusion Criteria: Patient with a normal perfusion lung scan Person under legal guardianship

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patient with suspicion of Chronic ThromboEmbolic Pulmonary Hypertension (CTEPH)<br>right cardiac catheterization (usual practice) a blood sample (inclusion for all patients with suspicion) if diagnosis of Chronic thromboembolic pulmonary hypertension confirmed a another bood sample at 6 months | Biological: blood sample<br>* to realize proteomic analysis.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proteomic pattern associated with the diagnosis of Chronic thromboembolic pulmonary hypertension (CTEPH) | Analysis of the final diagnosis retained for the patient : Chronic thromboembolic pulmonary hypertension (CTEPH) (population of interest), pre-capillary Pulmonary Hypertension (PH) other than Chronic thromboembolic pulmonary hypertension (CTEPH), post-capillary Pulmonary Hypertension (PH), no Pulmonary Hypertension (PH). | Day: 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analysis of recording of hemodynamic data at diagnosis | hemodynamic data : pulmonary vascular resistance, cardiac index, pulmonary arterial pressures | Day: 0 | 
| Analysis of recording of hemodynamic data at diagnosis | hemodynamic data : pulmonary vascular resistance, | Day: 0 | 
| Analysis of recording of hemodynamic data at diagnosis | hemodynamic data : cardiac index | Day: 0 | 
| Analysis of recording of hemodynamic data at diagnosis | hemodynamic data : pulmonary arterial pressures | Day: 0 | 
| Analysis of recording of hemodynamic after 6 months of treatment | hemodynamic data : pulmonary vascular resistance, | 6 months | 
| Analysis of recording of hemodynamic after 6 months of treatment | hemodynamic data : cardiac index | 6 months | 
| Analysis of recording of hemodynamic data at diagnosis and at death | hemodynamic data : pulmonary arterial pressures | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pulmonary hypertension;, chronic thromboembolic pulmonary hypertension, pulmonary embolism, proteomic pattern