Correlation Between Body Mass Index and Progressive Grafted Bone in Cleft Patients

Study Overview
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Brief Summary
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The cleft patients received alveolar bone graft(ABG) for alveolar defect. Body mass index (BMI) was measured for each patients when receiving ABG. Bone mineral density was measured by Cone-Beam CT at two time-points: post-ABG six months, and post-ABG two years. The study was to analyze the correlation between BMI and post-operative bone mineral density.

Detailed Description
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Although childhood obesity is a growing issue, the association between BMI and the progressive bone mineral density (BMD) in grafted tissue after secondar alveolar grafting (ABG) remains little reviewed. This study compared the correlation between BMI and the progressive BMD after ABG procedure. Thirty-nine patients with unilateral or bilateral clefts were enrolled. ABG was performed at mixed-dentition age. Patient were classified into underweight, normal weight, and overweight or obese based on age- and sex-adjusted BMI. BMD was expressed in Hounsfield unit (HU) on cone-beam computed tomography (CBCT), which was obtained at 6 months (T1) and 2 years (T2) postoperatively. Calibrated BMD (HUgrafted tissue/HUpogonion¬, BMDc) was used for further analysis.

Official Title
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Correlation Between Body Mass Index and Progressive Bone Mineral Density in Cleft Patients After Secondary Alveolar Bone Grafting

Conditions
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Cleft Lip and Palate, Bone Graft; Complications

Intervention / Treatment
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* Procedure: alveolar bone grafting


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: nonsyndromic unilateral or bilateral cleft lip and alveolus with or without palate patients received secondary ABG at Chang Gung Craniofacial Center received team managements based on our current treatment protocol for cleft lip and palate Exclusion Criteria: syndromic cleft patients with failed grafted tissue

Ages Eligible for Study
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Minimum Age: 8 Years
Maximum Age: 10 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| cleft patients received alveolar bone grafting<br>alveolar bone grafting was performed when the cleft patients were aged around 9 years old. CBCT was used to analyze the bone mineral density of grafted tissue. | Procedure: alveolar bone grafting<br>* the surgery of alveolar bone graft for alveolar defect in cleft patients<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| bone mineral density | measuring the bone density from cone beam CT | post-ABG six months | 
| bone mineral density | measuring the bone density from cone beam CT | post-ABG two years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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alveolar bone grafting, body mass index, bone mineral density, cone beam computed tomography