Serum AMH Levels in Patients Who Underwent Hypogastric Artery Ligation

Study Overview
=================
Brief Summary
-----------------
To observe the effects of hypogastric artery ligation on serum antimullerian hormone levels.

Detailed Description
-----------------
To measure and compare serum antimullerian hormone levels in patients who underwent hypogastric artery ligation/ hypogastric artery ligation+ hysterectomy and postpartum control. The procedures performed as an emergency life saving method during delivery. The reasons for hypogastric artery ligation/ hypogastric artery ligation+ hysterectomy were obstetric hemorrhage mainly uterine atony. The serum levels of antimullerian hormone were measured 6 months after the operations and compared with matching postpartum controls. Serum levels of FSH, LH, PRL and TSH were also measured 6 months after the operation. Further, antral follicle count measured along with the aforementioned blood tests.

Official Title
-----------------
Serum Antimullerian Hormone Levels in Patients Who Underwent Hypogastric Artery Ligation

Conditions
-----------------
AMH

Intervention / Treatment
-----------------
* Procedure: hypogastric artery ligation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age 18- 40 years no systemic or endocrine diseases patients who had hypogastric artery ligation and/or hysterectomy healthy postpartum patients as controls Exclusion Criteria: history of chemotherapy and/or radiotherapy Obese patients patients with previous/present endometriosis patients with PCOS

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hypogastric artery ligation (HAL)<br>Patients who underwent only hypogastric artery ligation performed during the delivery of their babies. Six months after the operation they will evaluated for their ovarian reserve via hormones and astral follicle count (AFC) | Procedure: hypogastric artery ligation<br>* hypogastric artery ligation is the ligation of the internal iliac artery to stop bleeding related to obstetrics obstetric hemorrhage Hysterectomy is the removal of the uterus if bleeding can't stop by hypogastric artery ligation<br>* Other names: hysterectomy;|
| HAL and hysterectomy<br>Patients who underwent both hypogastric artery ligation and hysterectomy performed during the delivery of their babies. Six months after the operation they will evaluated for their ovarian reserve via hormones and astral follicle count (AFC) | Procedure: hypogastric artery ligation<br>* hypogastric artery ligation is the ligation of the internal iliac artery to stop bleeding related to obstetrics obstetric hemorrhage Hysterectomy is the removal of the uterus if bleeding can't stop by hypogastric artery ligation<br>* Other names: hysterectomy;|
| Postpartum<br>Postpartum control group constituted of patients delivered baby without any complication and evaluated 6 months later. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ovarian reserve | To evaluate postoperative ovarian reserve using anti-mullerian hormones and other ovary related hormones including FSH,LH | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
hypogastric artery, anti-mullerian hormone, ovarian reserve, postpartum