NHANES Urinary Sodium Calibration Study

Study Overview
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Brief Summary
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This proposed calibration study is designed to evaluate the correlation of urinary sodium excretion between NHANES timed urine and 24-hour urine collections.

Detailed Description
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The study will be conducted with 400 volunteer participants aged 18-39 years old. Participants will be asked to collect urine samples over a 24-hour period. One-third of the participants (n=133) will be asked to collect a second 24-hour urine 4-11 days later. A 24-hour dietary recall interview will be collected after the completion of each 24-hour urine collection. Results from this study will be used to assess how well the sodium excretion estimated from NHANES timed urine correlates with data from 24-hour urine collection. It will provide valuable information on the potential of NHANES timed urine collections to be used to characterize trends in U.S. population sodium intake.

Official Title
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National Health and Nutrition Examination Survey (NHANES), Urinary Sodium Calibration Study

Conditions
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Nutrition Assessment

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: English speaking Aged 18-39 years old 50% Black; 50% all other 50% male; 50% female At least 50 (25 male; 25 female) of the 400 participants likely to have high sodium diet indicated by selected dietary behaviors At least 50 (25 male; 25 female) of the 400 participants likely to have low sodium diet indicated by selected dietary behaviors Exclusion Criteria: Pregnant or trying to get pregnant. Taking loop diuretics Chronic kidney disease New hypertension treatment or change in hypertension treatment in the last 2 weeks

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 39 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Adults 18-39 years<br>Healthy adults aged 18-39 years | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Usual sodium intake | Usual sodium intake based on 24-hour sodium excretions (two measurements for a one-third subset 4-11 days after the first collection) using measurement error models | one day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Usual potassium intake | Usual potassium intake based on 24-hour potassium excretions (two measurements for a one-third subset) using measurement error models | one day | 
| Creatinine excretion | Based on 24-hour creatinine excretion | one day | 
| Usual iodine intake | Usual sodium intake based on 24-hour sodium excretions (two measurements for a one-third subset 4-11 days after the first collection) using measurement error models | one day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Sodium, Potassium, Iodine, Creatinine