Khalifa Acute Effects

Study Overview
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Brief Summary
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The primary hypothesis is that Khalifa's therapy has different acute effects in various organ systems i.e. proprioceptive, neuro-muscular, endogenous dopamine system, etc. These effects might indicate the pathway of the therapy.

Detailed Description
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According to our previous study that evaluated the efficacy of Khalifa's therapy the investigators have seen that the therapy has acute effects which resulted in better knee function and later even in better healing of the ACL injury. This study should clear exactly which effects and pathways are involved in the therapy from multiple (interdisciplinary) point of views. Therefore the investigators will measure parameters that might be associated with this special technique directly before and after the therapy.

Official Title
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Interdisciplinary Evaluation of Acute Effects From Khalifa's Therapy at Patients With Fully Ruptured Anterior Cruciate Ligament (ACL).

Conditions
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Totally Ruptured Anterior Cruciate Ligament in the Knee

Intervention / Treatment
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* Other: Khalifa Therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: totally ruptured ACL - MRI verified, 2 weeks old as a maximum knee function: Any functional inhibition (stretching, bending or load) BMI: 18-25 athletically active Exclusion Criteria: any surgical procedures at the injured knee at any previous time any acute surgical indication diabetes mellitus and/or high blood pressure any permanent drug treatment

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 49 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: K-Pat<br>Getting one time one hour of Khalifa's therapy for ACL injury treatment. | Other: Khalifa Therapy<br>* One hour of Khalifa's therapy which is specially applied pressure to the skin.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Laser Doppler-Flow | Perfusion | 1 hour | 
| NIRS | Near infrared spectroscopy, Oxygen saturation | 1 hour | 
| IR Thermography | Infrared thermography, temperature | 1 hour | 
| QST | Quantitative sensoric testing, pain | 1 hour | 
| HRV | Heart rate variability, sympathicus/parasympathicus activation | 1 hour | 
| EEG | Electroencephalogram, brain waves | 1 hour | 
| Knee function | IKDC Score KT-1000 test Clinical / physical examination | 1 hour | 
| SportsScience | Posturomed Motion capture proprioception muscle power range of motion | 2 hours | 
| Blood | Catecholamines endorphins standard blood parameters | 1 hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Questionnaire | Different questions about pain, lifestyle, subjective parameters | 1 hour | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ACL, Knee, Ligament, Cruciate, Anterior