Cardiovascular Prophylaxis for Postmenopausal Women

Study Overview
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Brief Summary
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The purpose of this study was to examine the effect of 6 months moderate intensity exercise training completed three times per week upon traditional and emerging cardiovascular disease risk factors in postmenopausal women both with and without type 2 diabetes. These risk factors include blood markers associated with increased risk such as cholesterol, insulin, glucose and markers of inflammation plus measures of body fat, heart and lung fitness, vascular stiffness and vascular function. The study hypothesised that moderate intensity exercise training would intervene in the exaggerated risk seen in women following the menopause, especially in those with type 2 diabetes.

Official Title
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Can a Moderate Intensity Exercise Training Programme Improve Cardiac Function and Known Cardiovascular Risk Factors in Middle-aged Women?

Conditions
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Cardiovascular Disease

Intervention / Treatment
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* Behavioral: Exercise training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy and stable type II diabetic postmenopausal women (cessation of menstrual periods for 12 months and confirmed with LH/FSH samples) aged 45 - 65 years old for the cross sectional analysis and exercise training study. Exclusion Criteria: Identified abnormalities during baseline testing. Vigorously active women. Women who are pregnant. Women with serious systemic or psychological disorders (e.g. COPD, asthma, clinical depression). Women with known coronary artery disease. Women with significant cardiovascular pathologies and associated medication. Women with type 1 or insulin treated diabetes. Women with diabetes with complications. Women with unstable diabetes or hypertension. Women with any cancer. Women with musculoskeletal impairments or contraindications to exercise.

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Exercise training|6 months of moderate intensity exercise training 3 times per week|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximal oxygen uptake |  | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| lipoprotein profile |  | 6 months | 
| Flow mediated dilation |  | 6 months | 
| Cardiac power output |  | 6 months | 
| Arterial stiffness |  | 6 months | 
| Inflammatory markers |  | 6 months | 
| Body composition |  | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Body composition, Endothelial function, Lipoprotein profile, Inflammatory markers, Aerobic capacity, Thrombotic markers, Arterial stiffness, Cardiac function, Traditional and emerging cardiovascular disease risk factors