An Advanced Echocardiographic Evaluation of Nebivolol

Study Overview
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Brief Summary
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The purpose of this study is to determine if Nebivolol has any effect on heart function determined by changes in echocardiographic data or exercise tolerance.

Detailed Description
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Subjects will be given either 5 or 10 mg daily of oral Nebivolol for blood pressure control. They will undergo stress echocardiography at baseline, day 14, 90 and 180.

Official Title
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An Advanced Echocardiographic Evaluation of Nebivolol

Conditions
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Hypertension

Intervention / Treatment
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* Drug: nebivolol


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis of hypertension Written informed consent before initiation of any study related procedure Baseline Blood pressure > 140 systolic or >90 diastolic if on no antihypertensive therapy. Currently taking one antihypertensive or one antihypertensive and one diuretic for the treatment of hypertension. Exclusion Criteria: Physical limitations resulting in a limited ability to walk on treadmill for stress echo Intolerance to beta blockers On more than one medication for the treatment of hypertension unless the second medication is a diuretic. Currently pregnant or breast feeding. LFT > 3 X ULN HgA1C > 7 Participation in other clinical research studies involving the evaluation of other investigational drugs or devices within past 30 days of enrollment Unwilling to follow protocol or return for study related procedures. Any of the following conditions: Coronary artery disease Heart failure Valvular heart disease Ischemic heart disease Atrial fibrillation Pacemaker ICD Hyperlipidemia Diabetes Mellitus Stroke/TIA Anemia COPD Asthma Renal failure requiring dialysis Liver failure Cirrhosis Thyroid dysfunction Any other medical condition that in the PI's opinion could affect myocardial function. Current ETOH or illicit drug abuse -

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Nebivolol 5 or 10 mg, oral, daily<br>Subject will receive either 5 or 10 mg of oral nebivolol daily. Dose will be determined by control of blood pressure. | Drug: nebivolol<br>* nebivolol 5 or 10 mg oral, daily<br>* Other names: Bystolic;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Systolic and Diastolic Myocardial Function | Cannot report as only 1 patient was evaluated and data will not be able to remain anonymous. | Baseline to day 180 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Exercise Tolerance | Changes in exercise tolerance and time from baseline to 180 days. | Baseline to day 180. |