ARMOR Study: COVID-19 Seroprevalence Among Healthcare Workers

Study Overview
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Brief Summary
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The novel coronavirus (SARS-CoV-2) has spread all around the world and testing has posed a challenge globally. Health care providers are highly exposed and are an important group to test. On top of these concerns, health care workers are also stressed by the needs on responders in the COVID-19 crisis. The investigators will look at different ways to measure how common COVID-19 is among health care workers, how common is the presence of antibodies by serological tests (also known as serostatus). The investigators will describe health worker mental and emotional well-being and their coping strategies in their institutional settings. Lastly, the investigators will describe how knowing serostatus can affect individuals' mental and emotional well-being and how to cope in the midst of the COVID-19 response. This will help to how to better test and help healthcare workers in the COVID-19 pandemic and prepare for possible future outbreaks.

Detailed Description
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The rapid spread of the novel coronavirus SARS-CoV-2 has resulted in pandemic levels and a global challenge in diagnosing infection. Diagnosing infection, defining recovery and immunity has been challenging. Health care providers in particular are very interested in knowing their status as they are highly exposed, and if infectious, can potentially transmit infection nosocomially (in the healthcare workplace setting) and to their household. In addition to understanding their exposure risk, infectious period, and immunity status, health care workers are reporting high levels of psychosocial distress including anxiety and burnout. The investigators aim to assess the baseline and cumulative seroprevalence of SARS-CoV-2 among health care workers using both quantitative and qualitative serological assays; describe psychosocial well-being and coping strategies among health workers in their institutional settings and describe how knowledge of one's serostatus affect psychosocial well-being, and coping strategies. Findings from this study will inform; 1) use of serological assays and testing algorithms, and 2) approaches to manage psychosocial stress for healthcare workers.

Official Title
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SARS-CoV-2 Seroprevalence Among Healthcare Workers: ARMOR Study Demonstration Project

Conditions
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Covid-19, Coronavirus Infection, Coronavirus

Intervention / Treatment
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* Other: COVID-19 Serology
* Behavioral: Health Care Worker Survey


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 years of age or older NewYork-Presbyterian (NYP) healthcare personnel employee or affiliate Understands and reads English Exclusion Criteria: Younger than 18 years of age Mentally and/or physically unable to complete study requirements

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Prior Positive polymerase chain reaction (PCR) and Recovered<br>Prior Positive PCR result, fully recovered, back at work and symptom free for greater than or equal than 14 days. | Other: COVID-19 Serology<br>* Quantitate Serology enzyme-linked immunosorbent assay (ELISA) for COVID-19<br>Behavioral: Health Care Worker Survey<br>* The purpose of this survey is to assess how healthcare workers are experiencing and coping with the COVID-19 crisis.<br>|
| Never tested, history of COVID-19 Symptoms and Recovered<br>Never tested and history of COVID-19 symptoms and symptom-free for more than 14 days | Other: COVID-19 Serology<br>* Quantitate Serology enzyme-linked immunosorbent assay (ELISA) for COVID-19<br>Behavioral: Health Care Worker Survey<br>* The purpose of this survey is to assess how healthcare workers are experiencing and coping with the COVID-19 crisis.<br>|
| Never tested and current COVID-19 Symptoms<br>Never tested and current COVID-19 Symptoms (e.g. referred by a provider or clinic) | Other: COVID-19 Serology<br>* Quantitate Serology enzyme-linked immunosorbent assay (ELISA) for COVID-19<br>Behavioral: Health Care Worker Survey<br>* The purpose of this survey is to assess how healthcare workers are experiencing and coping with the COVID-19 crisis.<br>|
| Never tested and asymptomatic<br>Never tested and asymptomatic for COVID-19 symptoms, including asymptomatic health care worker | Other: COVID-19 Serology<br>* Quantitate Serology enzyme-linked immunosorbent assay (ELISA) for COVID-19<br>Behavioral: Health Care Worker Survey<br>* The purpose of this survey is to assess how healthcare workers are experiencing and coping with the COVID-19 crisis.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion seropositive | Percentage of health care workers with positive serological markers to describe patterns in exposure, re-infection, clinical symptom, serological responses among health care workers based on their baseline serological status over a one year period. | Up to 12 months after collection visit |