linjc16/ctgov huggingface dataset:
Comorbidities and Indirect Health State Utility in Hip and Knee Osteoarthritis

Study Overview
=================
Brief Summary
-----------------
National cohort study aimed to investigate the impact of comorbidities (number and type of comorbidities) on health utility state change in lower lim osteoarthritis (hip and knee OA).

Detailed Description
-----------------
The concept of health utility state was developed by economists to explain individual choices and preferences for health states. It is expressed as the desirability or preference that individuals exhibit for the condition. This health utility state can be measured indirectly using health-relation quality of life questionnaires. Chronic diseases such as OA are known to be associated with impairment of quality of life. Given that OA prevalence increases with age, OA is often associated with other diseases (comorbidities). A cross-sectional study showed that comorbidities are associated with lower health utility state in OA. Investigation of longitudinal impact of comorbidities on health utility state change is need. Main objective: Determine the impact of comorbidities on change in health utility state among patients with lower limb OA. Secondary objective: Determine the Minimal Clinically important Difference in health utility state among patients with lower limb OA. The COMUTAR study uses longitudinal data from the Knee and Hip Osteoarthritis Longitudinal Assessment (KHOALA) cohort study. Health utility state is measured indirectly using Medical Outcome Study Short Form-36 quality of life questionnaire Comorbidities are assessed using the Functional Comorbidity Index

Official Title
-----------------
Impact of Comorbidities on Measure of Indirect Utility Change in Hip and Knee Ostearthritis

Conditions
-----------------
Osteoarthritis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age: 40-75 years Uni or bilateral lower limb osteoarthritis (OA) according to the American College of Rheumatology (ACR) and European league against rheumatism (EULAR) criteria Exclusion Criteria: Hip or knee prothesis Antecedent of osteotomy Severe comorbidity Adult under legal protection

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in health utility state | Change in health state utility score between the inclusion in the KHOALA cohort and 5 years later (T5-T0) | Five years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Minimal Clinically Important Difference (MCID) of health utility state |  | Five years |
The Influence of Coping Strategies and Catastrophizing on Patients With Back and Neck Pain

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the influence of coping strategies and catastrophizing thoughts on disability and the prognosis of back and neck pain in patients treated within the Spanish National Health Service. Patients will be given a visual analog scale (VAS) to rate intensity of pain, the Roland Morris Questionnaire (RMQ) or the Neck Disability Index (NDI) to rate the degree of disability, and the Coping Strategies Questionnaire (CSQ) to rate coping strategies and catastrophizing. Questionnaires will be given at baseline and three months later.

Official Title
-----------------
The Influence of Coping Strategies and Catastrophizing on Patients With Back and Neck Pain Treated Within the Spanish National Health Service

Conditions
-----------------
Back Pain, Neck Pain

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subjects treated for back or neck pain in the Spanish National Health Service. Able to read and write Spanish. Have signed the informed consent form. Exclusion Criteria: Diagnosis or red flags for systemic diseases (e.g., cancer, infection). Pain due to fracture or direct trauma to the neck or back. Criteria for referral to surgery (e.g., neurogenic claudication due to spinal stenosis, cauda equina syndrome, serious nerve root compression for more than 6 weeks due to disc herniation).

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disability |  | Baseline and 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain |  | Baseline and 3 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
back pain, neck pain, prognosis, catastrophizing, coping strategies, disability, Prognosis for back and neck pain
Vitamin D During Pregnancy

Study Overview
=================
Brief Summary
-----------------
Vitamin D insufficiency is common globally. Pregnant women, who need an increased supply of this vitamin for the proper development of the fetus, are a significant risk group. The purpose of this study is to examine which factors - education, knowledge from non-professional sources, recommendations from medical staff - influence the use of vitamin D among pregnant women in light of the lack of a clear health policy, and to help formulating guidelines for a new health policy with specific recommendations for vitamin D dosage in pregnancy.

Official Title
-----------------
Evaluation of the Influence of Education, Knowledge and Existing Guidelines on the Consumption of Vitamin D During Pregnancy.

Conditions
-----------------
Vitamin D Deficiency

Intervention / Treatment
-----------------
* Other: completion of a questionnaire
* Other: Blood draw


Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria for the pregnant of newly post-partum women: women between 18-50 pregnant or just given birth and still hospitalized understand and can read Hebrew Exclusion Criteria: those who do not understand or read Hebrew

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pregnant or newly post partum women<br> | Other: completion of a questionnaire<br>* Completion of a questionnaire<br>Other: Blood draw<br>* A subset of 100 women will have a blood test to measure Vitamin D levels<br>|
| family practice physicians and obstetricians<br> | Other: completion of a questionnaire<br>* Completion of a questionnaire<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Use of Vitamin D in Pregnant Women |  | 3 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pregnancy, Vitamin D
Pain Perception is Attenuated in Patients With Painless Myocardial Infarction

Study Overview
=================
Brief Summary
-----------------
To explore whether reduced systemic pain perception in response to painful stimuli and personality pain related variables characterizes silent MI patients.

Detailed Description
-----------------
Objective: Silent myocardial infarction (MI) is an event of severe myocardial ischemia without pain experience. The lack of pain alarm leads to increased morbidity and mortality, because the patients do not sick timely medical treatment. This study aims to explore whether reduced systemic pain perception in response to painful stimuli and personality pain related variables characterizes silent MI patients. Methods: Level of chest pain intensity was assessed by visual analogue scale (VAS), range from 0 (no pain) to 100 (maximal pain). Heat pain threshold, magnitude estimation of supra-threshold painful stimuli at 47ºC as well as pain catastrophizing scores were assessed in 90 acute MI patients (mean age 66±12.1, range 33-79) with chest pain (n=65) and without pain symptoms(n=25). All stimuli were performed by Thermal Sensory Analysis (TSA) and applied to the right forearm. Results: The demographic variables, history of ischemic heart, risk factors for coronary artery disease, ST-T segment changes on ECG and troponin levels were similar in both groups. Greater intensity of chest pain VAS scores was inversely correlated with lower pain threshold (r= -0.417, p<0.001), and directly associated with higher pain scores in response to the heat pain (r=0.354, p=0.002). Patients with painful MI demonstrated lower pain threshold (41.9±3.6 vs. 44.9±3.8, p=0.001), higher VAS scores in response to the supra-threshold painful stimuli (50.2 ±21.8 vs. 27.0±25.2, p=0.002), and higher catastrophizing level (10.6±12.0 vs. 5.4±8.8, p=0.032). Chest pain complaint was not related to ST-T changes as well as concomitant diseases. Conclusions: This study suggests that reduced systemic pain perception as well as cognitive personality variables play an important role in the etiology of Silent MI.

Official Title
-----------------
Clinical and Experimental Pain Perception is Attenuated in Patients With Painless Myocardial Infarction

Conditions
-----------------
Myocardial Infarction, Myocardial Ischemia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria:All patients with painless or painful myocardial infarction - Exclusion Criteria:Patients who can't give informed concent or couldn't cooperate -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Therma,pain, Silent myocardial ischemia, catastrophizing
Validity and Reliability of The Turkish Version of Breathlessness Beliefs Questionnaire

Study Overview
=================
Brief Summary
-----------------
In our study, we aimed to evaluate the validity and reliability of the Turkish version of the Breathlessness Beliefs Questionnaire-BBQ in our study.

Detailed Description
-----------------
Pulmonary diseases are a common cause of mortality and morbidity throughout the world. In pulmonary diseases such as asthma and COPD, the main symptom is dyspnea and it causes activity limitation. Dyspnea is defined as the difficulty that a person experiences during breathing. As a result of painful situations or injuries, avoidance of physical activity or movement due to the fear of repetition of the problem are defined as kinesophobia. Pulmonary patients are compensated by reducing the rate of activity, while avoiding dyspnea.This reduces the severity of the symptom that precedes the symptom that may occur. As a result, dyspnea causes kinesyphobia. Decrease in the level of activity; social isolation, fear of dyspnea, depression and anxiety result in a stubborn cycle, quality of life is reduced. The Breathlessness Beliefs Questionnaire (BBQ) was developed based on the Tampa Kinesiophobia Scale to assess dyspnea and dyspnoea-related kinesophobia and anxiety in respiratory diseases.

Official Title
-----------------
Validity and Reliability of The Turkish Version of Breathlessness Beliefs

Conditions
-----------------
Dyspnea, COPD

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: FEV1/FVC<%70 To be able to read and understand Turkish Exclusion Criteria: Having undergone a COPD exacerbation in the last 6 weeks Having comorbidities affecting ambulance Having cognitive disorders

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Breathlessness Beliefs Questionnaire-BBQ | Breathlessness Beliefs Questionnaire-BBQ Breathlessness Perception Questionnaire; is a measure evaluating kinesophobia and anxiety due to the breathlessness of 17 questions answered by one's own practice. Patients score from 1 to 5 (I strongly agree). High scores indicate high levels of kinesiophobia and anxiety due to breathlessness. | 3 Minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
COPD, Dyspnea, Kinesiophobia
Cocaine Abuse and Attention Deficit Disorder - 3

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate cocaine abuse and Attention Deficit Disorder

Detailed Description
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To evaluate the safety and efficacy of methylphenidate and bupropion in treating individuals with adult Attention Deficit Disorder.

Official Title
-----------------
Cocaine Abuse and Attention Deficit Disorder

Conditions
-----------------
Cocaine-Related Disorders

Intervention / Treatment
-----------------
* Drug: Bupropion


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: current adult ADHD current cocaine dependence Exclusion Criteria: no current major depression

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Bupropion|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Side effects |  |  | 
| Craving |  |  | 
| Drug use |  |  | 
| ADHD symptoms |  |  | 
| Improvement in functioning |  |  | 
| Tolerability |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cocaine dependence
Microcirculatory Mapping of the Aging Hand and Foot

Study Overview
=================
Brief Summary
-----------------
Currently, dorsal hand rejuvenation is an upcoming issue as patients seek plastic surgeons to address this highly visible area, although no specific statistics concerning the number of patients undergoing dorsal hand rejuvenation have been published yet. The solitary use of fillers, fat, sclerotherapy, skin excision, resurfacing and combinations of the above mentioned therapies have been reported in the literature, but still there is a lack of scientific literature about functional microcirculation of the dorsum of the hand. Furthermore, there is a lack of scientific data about functional microcirculation of the plantar foot in healthy subjects compared to patients suffering from Diabetes mellitus or peripheral arterial occlusive disease. Consequently, the aim of this study is the evaluation of the functional microcirculation of hands and feet in healthy subjects as well as patients suffering from the above mentioned diseases.

Conditions
-----------------
Cutaneous Microcirculation in Vascular Diseases

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Both healthy subjects and patients suffering from diabetes mellitus or manifested peripheral arterial occlusive disease aged between 18 and 75 years Exclusion Criteria: soft tissue inflammation or osteomyelitis, liver disease, cardiac dysfunction, arterial hypotension

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy subjects<br> | |
| Patients suffering from Diabetes mellitus<br> | |
| Patients suffering from peripheral arterial occlusive disease<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation of microcirculation to age and incidence of vascular diseases |  | 7 months |
Construction and Validation of Risk Prediction Model for PICC Catheter Displacement

Study Overview
=================
Brief Summary
-----------------
The occurrence of PICC catheter displacement is caused by many factors. In order to predict the risk of PICC and early warn high-risk patients, this study prospectively included patients with PICC catheter in a three Grade-A hospitals in June 2019, analyzed a variety of related factors, built a scientific and effective risk prediction model of PICC catheter displacement, and verified the goodness of fit and differential validity of the model.

Official Title
-----------------
Construction and Validation of Risk Prediction Model for PICC Catheter Displacement

Conditions
-----------------
Cancer Patients With PICC

Intervention / Treatment
-----------------
* Other: Logistic Regression Analysis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with PICC Exclusion Criteria: Patients with primary ectopia during PICC catheterization Patients with secondary ectopic adjusting length of catheter exposure Patients with mental illness and cognitive impairment Patients with incomplete clinical data

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Modeling Group<br> | Other: Logistic Regression Analysis<br>* Using logistic regression analysis to analyze the independent risk factors of PICC catheter displacement<br>|
| Validation Group<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prediction Model of PICC catheter displacement | A mathematical model for predicting PICC catheter displacement | 3 years |
Fertility and Cardiovascular Risk in Men With Metabolic Syndrome

Study Overview
=================
Brief Summary
-----------------
Men diagnosed with metabolic syndrome (MetS) including obesity, hypertension, dyslipidemia and infertility will be assessed for cardiovascular and diabetes risk. The eligible patient will be randomised to one-year life-style intervention program including nutritional, behavioural and exercise counselling or standard care by the general physician. The aim of the program is to reduce cardiovascular and diabetes risks and hypogonadism as well.

Official Title
-----------------
Fertility and Cardiovascular Risk in Men With Metabolic Syndrome

Conditions
-----------------
Metabolic Syndrome

Intervention / Treatment
-----------------
* Behavioral: Life style change and weight reduction


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age>18 years, wish for fatherhood in stable partnership, metabolic syndrome according to guidelines (minimum 3 out of 5 criteria), ready to participate in 1-yr lifestyle program Exclusion Criteria: Not conforming to MetS diagnosis criteria, sterilisation, promiscuous behaviour, contraindications against established medical or surgical treatment of obesity, participation in another weight-loss program

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intensive treatment group<br>The intensive treatment group will pass a life-style intervention program including consequent escalation of measures to reach sustained reduction of 10% of initial body weight at minimum. | Behavioral: Life style change and weight reduction<br>* Nutritional, behavioural, and exercise counselling to reduce body weight by 10%, normalise blood glucose, lipids, blood pressure, and testosterone level.<br>|
| No Intervention: Standard treatment group<br>Patients will be taken care of by general physician without lifestyle program. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of participants with normalisation of diabetes or cardiovascular risk or improvement of hypogonadism | Diabetes risk Glycated hemoglobin >5.7%, Cardiovascular risk score >5%, Hypogonadism score increase of 20 points | 1 year |