Work Activity Augmented by Cognitive Rehabilitation for Schizophrenia

Study Overview
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Brief Summary
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This research investigates the benefits of productive activity and cognitive rehabilitation for patients with schizophrenia. Key questions are: does cognitive rehabilitation plus work activity produce better outcomes than work activity alone? Is cognitive rehabilitation more helpful for individuals with moderate or greater cognitive impairment than for individuals without such impairment? Does cognitive rehabilitation reduce the dropout rate and increase participation in work activity for cognitively impaired subjects? What features of cognitive rehabilitation are most important for clinical and rehabilitation outcomes?

Detailed Description
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This is a randomized, matching study in which subjects are stratified by degree of cognitive impairment, then randomly assigned to one of two conditions: Work Services Only vs. Work Services plus cognitive rehabilitation. Longitudinal analysis of work activity, work performance, symptoms, quality of life, cognitive function and service utilization are made.

Official Title
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Work Activity Augmented by Cognitive Rehabilitation: Continuation and Follow-up

Conditions
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Schizophrenia, Schizoaffective Disorder

Intervention / Treatment
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* Behavioral: cognitive rehabilitation
* Procedure: work therapy
* Behavioral: work therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: diagnosis of schizophrenia or schizoaffective disorder Exclusion Criteria: change in psychiatric medications or housing within 30 days of study intake episode of drug abuse within 30 days of study intake GAF score 30 or less known neurological disease or developmental disability

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1<br>work therapy | Procedure: work therapy<br>* opportunity to work in carefully supervised hospital job<br>* Other names: IWT;Behavioral: work therapy<br>* work therapy<br>|
| Experimental: 2<br>work therapy plus cognitive remediation | Behavioral: cognitive rehabilitation<br>* computer training<br>* Other names: computer training;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neuropsychological test performance |  | data collection completed | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hours of productive activity |  | data collection completed | 
| Hours worked |  | data collection completed | 
| Quality of life |  | data collection completed | 
| Psychiatric symptoms |  | data collection completed | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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work therapy, cognitive rehabilitation, schizophrenia, schizoaffective disorder, treatment outcome