Upside Down, Give me the Handle

Study Overview
=================
Brief Summary
-----------------
In schizophrenia, dislocation of psychic functions involving a loss of contact with reality is frequently found. A fragmentation of motor and sensory perceptions could be held responsible (Fuchs, 2005). However, automatic integration between perception and action is the necessary condition to be in relationship with the world. Affordance is the experimental link between object perception and actions potentially associated (Gibson (1977, 1979) explored by Stimulus Response Compatibility (SRC) paradigm. The existence of visual motor neurons leads us to postulate that the affordance effect can be assisted by a visuomotor priming of a hand in a position to grasp. With Tucker & Ellis sensory motor compatibility task, we study the capacity of affordance in schizophrenia, as well as the impact of perceptual motor priming on these affordance effects.

Detailed Description
-----------------
All participants will perform cognitive tasks: reaction time (Alert TEA, Zimmermann and Fimm, 2005), Edinburgh laterality questionnaire (Oldfield, 1971), IQ test (IQ: PM38, Raven, 1960), and the PANSS (Positive and Negative Syndrome Scale, Kay et al., 1987). Controls will only have the first three tasks (cognitive spots Alert and laterality). Then all will perform all tasks in successive order (task 1 and task 2). For both tasks, photographs of 20 objects of everyday life typical grip with one hand are presented in 4 orientations. The instruction is to say if the object is presented upright or inverted; The second task differs from the first only by the introduction of a prime: presenting a hand in position catching before the picture of an object

Official Title
-----------------
Study on the Links Between Perception and Action in Schizophrenia, Upside Down, Give me the Handle

Conditions
-----------------
Schizophrenic Disorders

Intervention / Treatment
-----------------
* Other: cognitive tasks + PANSS+ IQ
* Other: cognitive tasks


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: For patients: a DSM-IV diagnosis of schizophrenia (men or women), no change in antipsychotic medication and clinical status within four weeks prior to the study Exclusion Criteria: IQ < 70 For patients and control group Inclusion criteria - Age ≥ 18 years et ≤ 50 years Exclusion Criteria: History of head trauma, neurological disease with cerebral repercussion or not stabilized serious physical illness; psychotropic medication, disorders related to the use of a psychoactive substance (abuse, dependence or withdrawal);

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patients<br>patients suffering schizophrenic disorders and who will perform cognitive tasks + PANSS+ IQ | Other: cognitive tasks + PANSS+ IQ<br>* Patients will have cognitive tasks: reaction time (Alert TEA, Zimmermann and Fimm, 2005), Edinburgh laterality questionnaire (Oldfield, 1971), IQ test (IQ: PM38, Raven, 1960), and the PANSS (Positive and Negative Syndrome Scale, Kay et al., 1987<br>|
| Active Comparator: control group<br>healthy patients who will perform cognitive tasks | Other: cognitive tasks<br>* Patients will have cognitive tasks: reaction time (Alert TEA, Zimmermann and Fimm, 2005), Edinburgh laterality questionnaire (Oldfield, 1971),<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| response time | The gain provided by the compatible vs incompatible conditions (ms response time) | day 1 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Schizophrenia, motor and sensory perceptions