Acute Bronchiolitis in Infants and Allergic Asthma

Study Overview
=================
Brief Summary
-----------------
Predicting the risk of allergenic sensitizations and asthma development in the first year of life is difficult. Investigator decided to follow prospectively two cohorts of infants with acute bronchiolitis, hospitalized or treated at home, from the epidemic seasons of 2011-2012 and 2015-2017 to know their respiratory evolution, especially if they developed allergen sensitization and / or asthma.

Detailed Description
-----------------
Follow-up consultation 6 years after an episode of acute bronchiolitis at Clermont-Ferrand hospital with: Consultation with a pneumopediatrician: collection of respiratory symptoms, respiratory treatments, evaluation of the atopic site and environmental risk factors for bronchial aggression, especially passive smoking; Physical examination ; Evaluation of precariousness during the same interview with the EPICES questionnaire; Prick tests with positive control (histamine) and negative (physiological saline) and prick for the main pneumallergens (mites, alternaria, grasses, cat and dog) and trophallergens (egg, milk, fish, soy, wheat, peanut); Blood test with blood count, determination of specific IgE (5 pneumallergens and 5 trophallergens), dosage of sRAGE; Fonctionnal respiratory test with reversibility test

Official Title
-----------------
Risk of Allergic Asthma Occurring in the Long Term From an Episode of Acute Bronchiolitis in Infants: Clinical, Allergological and Functional Evaluation in the Long Term

Conditions
-----------------
Acute Bronchiolitis, Asthma, Allergy

Intervention / Treatment
-----------------
* Diagnostic Test: Pneumological evaluation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Acute bronchiolitis in an infant less than one year old, included in studies KL6 (winter period 2011-2012) or CC16 (winter period 2015-2016) at clermont-ferrand hospital. Exclusion Criteria: Bronchopulmonary dysplasia; History of prematurity <34 AS; Mucoviscidosis; known immune deficiencies; Primary ciliary dyskinesia suspected; Congenital heart disease; Acute renal failure. Refusal of parents to participate

Ages Eligible for Study
-----------------
Minimum Age: 7 Years
Maximum Age: 9 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: group 1<br>cohorts of infants with acute bronchiolitis | Diagnostic Test: Pneumological evaluation<br>* Consultation with a pneumopediatrician: collection of respiratory symptoms, respiratory treatments, evaluation of the atopic site and environmental risk factors for bronchial aggression, especially passive smoking<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Risk factors for asthma 6 years after an episode of acute bronchiolitis | Presence / absence of asthma 6-9 years after an episode of bronchiolitis during the first year of life The diagnosis of asthma is established during a consultation by a pneumopediatrician on the following criteria: ≥3 documented respiratory symptoms ≥ 2 times; Or an episode lasting ≥ 4 weeks; With symptoms: tachypnea, wheezing, expiratory stridor, signs of chest retraction or wheezing diagnosed by a doctor. | at 6 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between onset of asthma and severity of bronchiolitis | Severity of acute bronchiolitis, assessed by a clinical score based on control signs, spO2 and respiratory rate (Wainwright score) and the length of hospital stay | at 6 years | 
| relationship between KL-6 serum markers and the occurrence of longer-term asthma | Correlation between onset of asthma and concentration of KL-6 during bronchiolitis | at 6 years | 
| relationship between CC16 serum markers and the occurrence of longer-term asthma | Correlation between onset of asthma and concentration of CC16 during bronchiolitis. | at 6 years | 
| relationship between sRAGE serum markers and the occurrence of longer-term asthma | Correlation between onset of asthma and concentration of sRAGE during bronchiolitis | at 6 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
allergic asthma, acute bronchiolitis, allergic sensitization, -risk factor