Unilateral Posterolateral Approach for Spondylodiskitis

Study Overview
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Brief Summary
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This retrospective study assess the efficacy and safety of a posterolateral unilateral approach for debridement and titanium cage insertion supplemented by contralateral transfascial screw fixation for sick patients suffering from septic thoracolumbosacral spondylodiskitis. Hematogenous pyogenic spondylodiskitis requires surgical intervention in cases of development of neurological signs, spinal instability, progressive spinal deformity and abscess. When operative treatment is indicated, an anterior approach by open thoracotomy or by a thoraco-abdominal approach or combined anterior and posterior approaches are recommended. In cases of severe sick patients anterior approach is associated with high morbidity and mortality.

Detailed Description
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Twenty consecutive sick (ASA>III) patients, 14 men and 6 women, aged 64±14 years, suffering from single level septic thoracolumbosacral spondylodiskitis underwent an one-stage less invasively unilateral posterolateral decompression, insertion of titanium cage& pedicle screw fixation plus contralateral transfascial pedicle screw fixation.

Official Title
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Unilateral Posterolateral Approach for Disc Debridement and Titanium Cage Insertion Supplemented by Contralateral Transfascial Screw Fixation for Sick Patients Suffering From Septic Thoracolumbosacral Spondylodiscitis

Conditions
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Discitis

Intervention / Treatment
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* Procedure: Unilateral Posterolateral Approach and Debridement
* Other: Titanium cage insertion supplemented by screw fixation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Single-level thoracic, thoracolumbar, lumbar or lumbosacral spondylodiskitis Medical comorbidities were present in all 20 patients. These included diabetes mellitus, chronic renal insufficiency, advanced heart insufficiency, hypertension, cortisone abuse, drug abuse and/or advanced age (>65y). Exclusion Criteria: -

Ages Eligible for Study
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Minimum Age: 44 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Septic spondylodiscitis<br>A unilateral posterolateral approach and debridement with titanium cage insertion supplemented by screw fixation for severe sick patients suffering from septic spondylodiscitis | Procedure: Unilateral Posterolateral Approach and Debridement<br> <br> Other: Titanium cage insertion supplemented by screw fixation<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The extent of spinal cord injury (SCI) defined by the American Spinal Injury Association (ASIA) Impairment Scale | Grade A Complete lack of motor and sensory function below the level of injury (including the anal area) Grade B Some sensation below the level of the injury (including anal sensation) Grade C Some muscle movement is spared below the level of injury, but 50 percent of the muscles below the level of injury cannot move against gravity. Grade D Most (more than 50 percent) of the muscles that are spared below the level of injury are strong enough to move against gravity. Grade E All neurologic function has returned. | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Survival rate at 2,5 years | Revision surgery or worst case scenario | 2,5 years | 
| Survival rate at 10 years | Revision surgery or worst case scenario | 10 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Spondylodiscitis, Titanium Cage, Posterolateral Debridement, Immunosuppressed, Less Invasive, Spine Infection