Age Influence on Cortical Bone Measured by Ultrasound

Study Overview
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Brief Summary
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The study of this study is to evaluate the age influence on cortical bone strength properties by two methods:HR-pQCT (HighResolution-peripheral quantitativeComputedTomography) and ultrasound. The main objective consists in the evaluation of the age influence on cortical thickness at 1/3 distal radius measured by US.

Detailed Description
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The study of this study is to evaluate the age influence on cortical bone by two methods: HR-pQCT and ultrasound. 84 patients will be measured. The cohort will be: 21 women less than 70 21 women more than 70 21 men less than 70 21 men more than 70 Measurement will be performed at radius and at tibia (ultra-distal and distal). For all the sites one measurement will be performed by HR-pQCT to get reference values of thickness and BMDs. For the distal positions and additional measurement will be performed by an innovative ultrasound device that estimates cortical thickness and porosity. The participation to the study implies only a participation of one hour from the patient (30min for HR-pQCT measurements, 30 min for US). The main objectives consist in : evaluating the age influence on cortical thickness at 1/3 distal radius measured by US evaluating the age influence on cortical thickness at distal tibia measured by US comparing porosities values measured by US to vBMD obtained by HR-pQCT comparing cortical thickness values measured by HR-pQCT at 1/3 distal radius position to ultra-distal radus position and to the tibia comparing vBMD values measured by HRpQCT at 1/3 distal radius position to ultra-distal radius position and to the tibia

Official Title
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Age Influence on Cortical Bone Measured by Ultrasound

Conditions
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Cortical Bone Erosion

Intervention / Treatment
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* Other: Bone measurement by HR-pQCT and ultrasound


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: being 18 or older coming from the rheumatology consultation at Lariboisière Hospital Exclusion Criteria: BMI > 28 BMI < 15 cortisone treatment recent fracture at non-dominant arm wound on measuring zone treatment interfering with bone architecture or bone density : oral of transdermic oestrogenes, bisphosphonates (Alendronate, Risedronate, Zoledronate) or Denosumab during the past 6 months-

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Bone measurement by HR-pQCT and ultrasound|Measurement will be performed at radius and at tibia (ultra-distal and distal). For all the sites one measurement will be performed by HR-pQCT to get reference values of thickness and BMDs. For the distal positions and additional measurement will be performed by an innovative ultrasound device that estimates cortical thickness and porosity.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cortical parameters measurement | Cortical thickness at distal radius 1/3 | Inclusion time | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tibia parameters measurement by US | Cortical thickness distal 1/2 tibia obtained by US ultra-distal and 1/3 distal cortical thicknesses obtained by HR-pQCT ultra-distal and 1/3 distal vBMD obtained by HR-pQCT | Inclusion time | 
| Tibia parameters measurement by HR-pQCT | Cortical thickness distal 1/2 tibia obtained by HR-pQCT ultra-distal and 1/3 distal cortical thicknesses obtained by HR-pQCT ultra-distal and 1/3 distal vBMD obtained by HR-pQCT | Inclusion time | 
| Porosity measurement | Ultrasonic porosity obtained by HR-pQCT | Inclusion time | 
| vBMD measurement | vBMD obtained by HR-pQCT | Inclusion time | 
| Cortical parameters measurement | 1/3 distal cortical thicknesses obtained by HR-pQCT | Inclusion time | 
| Thicknesses measurement | Ultra-distal thicknesses obtained by HR-pQCT | Inclusion time | 
| Ultra-distal vBMD measurement | Ultra-distal vBMD and third distal obtained by HR-pQCT | Inclusion time | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Osteoporosis