linjc16/ctgov huggingface dataset:
Evaluation of Risk Factors of Sleep Quality in Intensive Care Unit

Study Overview
=================
Brief Summary
-----------------
The aim of this study was to investigate the relationship between sleep disturbances and delirium in surgical ICU patients. The study set up to test the hypothesis that the occurrence of delirium is associated to the alteration of sleep quality and quantity observed in the critically ill patients.

Detailed Description
-----------------
Sleep disorders are an important clinical entity affecting outcome in respiratory, cardiovascular, metabolic and psychiatric disorders and exacting a potentially significant toll on patients at both a personal and socio-economic level.Delirium is a common organ dysfunction in the critically ill patients characterized by an acute onset of impaired cognitive function [REF] associated with prolonged ICU and hospital stay, nosocomial pneumonia, and death.

Official Title
-----------------
Evaluation of Risk Factors of Sleep Quality in Critically Ill Patients

Conditions
-----------------
Sleep Disorders, Delirium

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult, postsurgical patients who needed mechanical ventilation for more than 48 hr admitted to the general ICU Exclusion Criteria: Defined a priori Were history of chronic dementia, psychosis, mental retardation, stroke syndrome or other primary neurologic disease Patient refusal to participate Alcohol and drug abuse.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Sleep, ICU, Delirium, Post surgical ventilated patients, ICU patients
Oxygen Desaturation During Hemodialysis

Study Overview
=================
Brief Summary
-----------------
Hemodialysis patients may experience drops in blood oxygen saturation during the hemodialysis treatment, which may lead to hypoxia in the tissues. The investigators hypothesize that: The cumulative number, severity, or other characteristics of such deoxygenation episodes may be a predictor of adverse outcomes in hemodialysis patients. There may be demographic, anthropometric, clinical, treatment prescription, lab analytical, and other parameters that correlate with the number and severity of deoxygenation episodes and, therefore, may be used for risk stratification. Further, some of these parameters may be modifiable.

Official Title
-----------------
Oxygen Desaturation During Hemodialysis: Clinical Correlates and Association With Adverse Outcomes

Conditions
-----------------
Renal Disease, Hypoxia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Hemodialysis patient Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hemodialysis Patients<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cumulative number of deoxygenation episodes | Crit-Line III monitor recordings (which contain oxygen saturation data) will be extracted from the RRI database and the cumulative number of deoxygenation episodes will be analyzed. | Up to 36 months |
A Cross-sectional Study of Covid-19 Pandemic in Zhejiang Province

Study Overview
=================
Brief Summary
-----------------
this study adopted a cross-sectional study, collected the medical history and symptoms of patients infected with Covid-19 through a questionnaire survey, and made statistical analysis, so as to provide better clinical guidance.

Detailed Description
-----------------
Recently, there has been an outbreak of covid-19 in Zhejiang Province. In order to comprehensively understand the condition of patients with covid-19 in Zhejiang Province, this study adopted a cross-sectional study, collected the medical history and symptoms of patients infected with Covid-19 through a questionnaire survey, and made statistical analysis, so as to provide better clinical guidance.

Official Title
-----------------
A Cross-sectional Study of Covid-19 Pandemic in Zhejiang Province

Conditions
-----------------
Cross-sectional Study, COVID-19 Pandemic

Intervention / Treatment
-----------------
* Other: questionnaire


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: A positive nucleic acid test for Covid-19, or a positive antigen test for novel coronavirus, no age limit. Exclusion Criteria: Unable to understand the contents of the questionnaire for various reasons
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: questionnaire|This survey was conducted in Zhejiang Provincial Hospital of Traditional Chinese Medicine from December 2022 to December 2023. The research objects were patients with COVID-19.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| characters of patients with Covid-19 | this study collected the medical history and symptoms of patients infected with Covid-19 through a questionnaire survey, and made statistical analysis | baseline | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cross-sectional study, COVID-19 Pandemic
Detection of Mycoplasma Pneumoniae

Study Overview
=================
Brief Summary
-----------------
The objective of this Clinical Trial is to define the methods to be used to document that illumigene® Mycoplasma Direct meets its intended use claims, using the illumipro instrument, with throat swab samples collected from symptomatic patients.

Official Title
-----------------
Clinical Trial Protocol for the Illumigene® Mycoplasma Direct Assay

Conditions
-----------------
Mycoplasma Pneumoniae

Intervention / Treatment
-----------------
* Device: illumigene® Mycoplasma Direct, illumipro-10


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The subject has willingly given written informed consent. Specimens provided from subjects with symptoms of upper respiratory infections which may be attributable to Mycoplasma pneumoniae, or from patients suspected of having Mycoplasma pneumoniae. Dual throat swab collected per subject. Exclusion Criteria: Subjects who are unwilling to sign the written informed consent. Multiple sets of specimens collected from the same subject. Subjects who are unwilling or unable to provide the required number of throat swabs.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Specimen Collection<br>Prospective patients with symptoms of upper respiratory infections which may be attributable to Mycoplasma pneumoniae, or from patients suspected of having Mycoplasma pneumoniae. | Device: illumigene® Mycoplasma Direct, illumipro-10<br>* DNA amplification assay<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Qualitative detection of Mycoplasma Pneumoniae to aid in the diagnosis of M. pneumoniae infections. | Testing of each enrolled subject's samples will be performed within 14 days of collection. | Up to 14 days |
Exparel PK and Breast Milk Excretion

Study Overview
=================
Brief Summary
-----------------
Investigate the pharmacokinetics of Liposomal Bupivacaine and its excretion in breast milk in patients undergoing TAP block after their scheduled C -section delivery

Official Title
-----------------
Pharmacokinetics and Breast Milk Excretion of Liposomal Bupivacaine After TAP Block in Patients Undergoing Cesarean Section Delivery

Conditions
-----------------
Milk Expression, Breast

Intervention / Treatment
-----------------
* Drug: Bupivacaine liposome


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pregnant women >18 year old, scheduled for elective Cesarean delivery and who desire to have a TAP block performed after delivery. American Society of Anesthesiologists physical status I, II, and III Exclusion Criteria: Patient refusal or inability to cooperate. Allergy, hypersensitivity, intolerance, or contraindication to liposomal bupivacaine. Severely impaired renal or hepatic function (eg, serum creatinine level >2 mg/dL [176.8 µmol/L], blood urea nitrogen level >50 mg/dL [17.9 mmol/L], serum aspartate aminotransferase [AST] level >3 times the upper limit of normal [ULN], or serum alanine aminotransferase [ALT] level >3 times the ULN). Participants at an increased risk for bleeding or with any coagulation disorder (defined as platelet count less than 80, 000 × 103/mm3 or international normalized ratio greater than 1.5) (all contraindications to TAP block). Clinically significant medical disease in either the mother or baby that, in the opinion of the investigator, would make participation in a clinical study inappropriate. This includes any psychiatric or other disease in the mother that would constitute a contraindication to participation in the study or cause the mother to be unable to comply with the study requirements. Patient membership in a vulnerable population such as a prisoner, mentally unable to provide direct consent etc. Participant has contraindication to breastfeeding or not planning to breastfeed the first 2-3 days after delivery.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Bupivacaine liposome|blood and milk samples will be obtained from those subjects after TAP block|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| milk plasma ratio | AUC for the milk/plasma drug ratio | 72 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| AUC of plasma | AUC for drug concentration in plasma | 72 hours | 
| AUC of milk | AUC for drug concentration in milk | 72 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Liposomal bupivacaine, TAP block, cesarean section
Study Comparing Short Infusion Vs. Fixed Dose of Cisplatin + Gemcitabine in Non Small Cell Lung Cancer.

Study Overview
=================
Brief Summary
-----------------
The purposes of this study are to determine: How standard gemcitabine plus cisplatin compares to fixed dose rate of gemcitabine plus cisplatin in the treatment of non-small cell lung cancer. The safety of standard gemcitabine plus cisplatin and any side effects that might be associated with it as compared to a fixed dose rate of gemcitabine plus cisplatin.

Official Title
-----------------
Randomized Phase II Study of Cisplatin + Gemcitabine Administered Either as Short Infusion or at a Fixed Dose Rate in Non-Small Cell Lung Cancer

Conditions
-----------------
Non-Small-Cell Lung Carcinoma

Intervention / Treatment
-----------------
* Drug: Gemcitabine
* Drug: cisplatin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: At least 18 years of age Histologically or cytologically confirmed diagnosis of NSCLC Have provided written informed consent Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1 Adequate organ function Exclusion Criteria: Prior chemotherapy or biologic therapy (approved or experimental) for NSCLC Presence of uncontrolled central nervous system (CNS) metastases Inability to comply with protocol or study procedures Pregnancy Breast feeding

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Gemcitabine|nan|
|Drug: cisplatin|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To evaluate the objective response rate (ORR) of the standard (30 minute infusion) versus a fixed dose rate (10 mg/m2/minute) of gemcitabine combined with cisplatin as treatment for advanced NSCLC after treatment completion. |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To evaluate progression-free survival of the standard versus a fixed dose rate of gemcitabine combined with cisplatin as treatment for advanced NSCLC. |  |  | 
| To evaluate incidence of laboratory and non laboratory adverse events by maximum Common Toxicity Criteria (CTC) toxicity grade and relationship to study drug of the standard versus a fixed dose rate of gemcitabine combined with cisplatin as treatment for |  |  |
Comparative Study of Postieror Ankle Fracture

Study Overview
=================
Brief Summary
-----------------
To compare the clinical efficacy of open reduction and internal fixation (ORIF) with plate and screw for postieror malleolar fractures.

Official Title
-----------------
Comparative Study of Postieror Malleolar Fracture With Plate and Screw Fixation

Conditions
-----------------
Postieror Malleolar Fracture, Treatment

Intervention / Treatment
-----------------
* Procedure: Plate fixation
* Procedure: Screw fixation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: supination-external rotation Ⅳ type injury Exclusion Criteria: Pion fracture; Isolated posterior ankle fracture.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: plate group<br>internal fixation with the plate | Procedure: Plate fixation<br>* internal fixation with the plate<br>|
| Experimental: screw group<br>internal fixation with the screw | Procedure: Screw fixation<br>* internal fixation with the screw<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| functional score | AOFAS function score for ankle | One year after surgery |
A 14-item Questionnaire Regarding Career Preferences Among Chinese Medical Undergraduate Students.

Study Overview
=================
Brief Summary
-----------------
This survey was performed as part of a career choice research program for undergraduate medical students. All students received a QR code link to the survey as part of their course work.

Detailed Description
-----------------
This survey was performed as part of a career choice research program for undergraduate medical students. All students received a QR code link to the survey as part of their course work, although participation was voluntary and anonymous. All participants received verbal and online explanations of the questionnaire and were informed that informed consent would be assumed if they completed and submitted the questionnaire. The questionnaire was administered, and data were collected using a free online tool.

Official Title
-----------------
MC-career Choice Questionnaire for Exploring Insights Regarding the Motivations of Chinese Medical Students.

Conditions
-----------------
Career Burnout, Student Burnout

Intervention / Treatment
-----------------
* Other: Questionnaire Survey


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Participants from several four-year student classes medical students were enrolled. Exclusion Criteria: Students who did not complete or declined to complete the questionnaire.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Medical students<br>Undergraduate medical students at one Medical University. | Other: Questionnaire Survey<br>* All students received a 'QR code' link to the survey.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Questionnaire Results | The questionnaire was administered, and data were collected using a free online tool.This score was a 7 point likert scale questionnaire, the minimum value was 1 and maximum value was 7, higher scores mean a stronger attitude. | 14 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
career choice, medical students
Return to Sports After ACLR

Study Overview
=================
Brief Summary
-----------------
Patients who were surgically treated with ACL reconstruction at a single clinic between 2013 and 2018 will be approached by a questionnaire regarding their return to sport after surgery. Questions will focus on the timepoint of the return, subsequent injuries, and the impact of the initial injury on the life of the patients. In addition, existing clinical data from the baseline visit and from the follow-up visits offered routinely to the patient will be used.

Official Title
-----------------
Return to Sports After ACLR (RTSACL)

Conditions
-----------------
Anterior Cruciate Ligament Injuries, Reconstruction

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age ≥18 ACL injury surgically treated with ACL reconstruction at the crossklinik or affiliated institutions between 1.1.2013 and 31.12.2018 Exclusion Criteria: different treatment approach to the injury (e.g. conservative, stimulation of healing response, surgical treatment for re-rupture etc.).

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time until return to sport | This will be based on a self reporting by the patient. | All patients will be asked in a cross sectional assessment, i.e. at one specific date (planned: May 31, 2021). The distance of this time point to the time of surgery will vary between 2 and 8 years. | 
| Occurrence of a subsequent injury after return to sport | This will be based on the self reporting by the patient | All patients will be asked in a cross sectional assessment, i.e. at one specific date (planned: May 31, 2021). The distance of this time point to the time of surgery will vary between 2 and 8 years. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Average Muscle Strength | Muscle strength is assessed by considering the flexion/extension ratio. This data will be collected retrospectively form the medical records, | At 1 year follow up. | 
| Relative frequency of coping strategies | A series of questions about the impact of the injury on the life of the patients will be answered by the patients | All patients will be asked in a cross sectional assessment, i.e. at one specific date (planned: May 31, 2021). The distance of this time point to the time of surgery will vary between 2 and 8 years. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
anterior cruciate ligament injuries, return to sport
Effect of Premature Luteinization on the Oocyte Quality in Oocyte Donation Program.

Study Overview
=================
Brief Summary
-----------------
Analyze the possible effect of the progesterone levels of the hCG administration on the oocyte embryo quality. The primary endpoint of this study is the pregnancy rate.

Conditions
-----------------
Premature Luteinization

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Oocyte donors; age range: 18 - 34; BMI: 18 - 29; long protocol. Exclusion Criteria: PCO syndrome;

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 34 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
VIBRANT Registry: Value of Information Based From Pacemaker Recordings and New Technologies

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to collect data from pacemakers and determine how this information is used by physicians to care for their patients with pacemakers.

Detailed Description
-----------------
The purpose of this registry is to gain a better understanding of how diagnostic capabilities in four Vitatron pacemakers (Selection AFm, Clarity, C-Series, and T-Series) are being utilized for the clinical management of a general pacing population. Pacemaker information and health status is collected from all patients enrolled.

Official Title
-----------------
VIBRANT Registry: Value of Information Based From Pacemaker Recordings and New Technologies

Conditions
-----------------
Pacemaker, Bradycardia

Intervention / Treatment
-----------------
* Device: Pacemaker


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: • Class I or Class II indication for dual chamber pacing Exclusion Criteria: Has an ICD or is a known candidate for an ICD
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Pacemaker|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Registry, Pacemaker, Diagnostics