Predictive Value of Doppler RSI for Prediction of AKI in Septic Patients in ICU

Study Overview
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Brief Summary
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Acute kidney injury (AKI) Diagnosis is based on rising creatinine. Intrarenal vasoconstriction occurs earlier and measuring flow resistance in the renal circulation (Renal Resistive Index (RRI)) could become part of vital organ function assessment using Doppler ultrasound. The aim of this study is to predict AKI in septic patients in ICU by measuring RRI on admission by comparing two groups of patients, first group with RRI of normal value (0.6-0.7) and the other group with high RRI more than 0.7 and both with normal renal function on admission.

Detailed Description
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Patients who have criteria of sepsis, with normal renal function on admission will undergo Renal Doppler Ultrasound examination to measure Renal resistive index. Patients will be divided into 2 groups: Group (A) patients with renal resistive index between 0.6 and 0.7 (normal RRI). Group (B) patients with renal resistive index more than 0.7 (high RRI).

Official Title
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Predictive Value of Doppler Renal Resistive Index for Prediction of Acute Kidney Injury in Septic Patients in Intensive Care Unit.

Conditions
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Acute Kidney Injury, Sepsis

Intervention / Treatment
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* Diagnostic Test: Renal Doppler Ultrasound


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who have criteria of sepsis on admission which include two or more of SIRS which include: (Temperature >38°C or <36°C, Heart rate >90/min, Respiratory rate >20/min or PaCO2 <32mmHg (4.3kPa) and White blood cell count >12000/mm3 or <4000/mm3 or >10% immature bands.) in addition to suspected or confirmed infection. Patients who have normal renal function on admission. Exclusion Criteria: Currently recovering from an AKI at the time of inclusion and Renal impairment on admission. Patients with obstructive renal failure, renal artery stenosis were excluded from this study. Patients on chemotherapy and/or radiotherapy. Pregnancy.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with RRI between 0.6 and 0.7<br>Normal renal resistive index | Diagnostic Test: Renal Doppler Ultrasound<br>* Measurement of Renal resistive index<br>|
| Patients with RRI more than 0.7<br>High renal resistive index | Diagnostic Test: Renal Doppler Ultrasound<br>* Measurement of Renal resistive index<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| incidence of AKI | incidence of AKI related to Renal resistive index. | 1 day at admission | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| APACHE III score | Acute Physiology and Chronic Health Evaluation scores. Score range (0 better - 299 worse) | 1 day at admission | 
| APACHE IV score | Acute Physiology and Chronic Health Evaluation scores. Score range (0 better - 286 worse) | 1 day at admission | 
| SOFA score | Sequential Organ Failure Assessment (SOFA) score. Score Range (0 better - 24 worse) | 1 day at admission | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Acute Kidney Injury, Sepsis