linjc16/ctgov huggingface dataset:
Feasibility of Critical Flicker Frequency Procedure for the Diagnosis of Minimal Encephalopathy

Study Overview
=================
Brief Summary
-----------------
All patients eligible for TIPS (Transjugular intrahepatic portosystemic shunt) procedure will be considered for inclusion. After written inform consent, psychometric tests in order to calculate the psychometric hepatic encephalopathy (PHES) score, the gold standard for the diagnosis of minimal encephalopathy and critical flicker frequency (CFF) will be performed before the TIPS procedure. After TIPS, patients will be followed during one year and the psychometric test and CFF will be performed every 3 months. 30 patients will be included. The main endpoint is the success rate of CFF. The secondary end points are Correlation between CFF and PHES score Performance of CFF and PHES score to predict the occurrence of overt encephalopathy after TIPS procedure A sample collection during TIPS procedure is also performed for validation of biomarkers

Official Title
-----------------
A Pilot Study Aiming to Assess the Feasibility of Critical Flicker Frequency for the Diagnosis of Minimal Encephalopathy in Patients With Cirrhosis

Conditions
-----------------
Cirrhosis

Intervention / Treatment
-----------------
* Other: Critical flicker frequency procedure


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with cirrhosis in whom a TIPS is indicated patients have given their informed consent te be included Exclusion Criteria: minor pregnant women patients who cannot see the red color refusal to participate

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Critical Flicker Frequency<br>Critical Flicker Frequency Procedure | Other: Critical flicker frequency procedure<br>* After TIPS, patients will be followed during one year and the psychometric test and Critical flicker frequency procedure will be performed every 3 months<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| success rate of Critical Flicker Frequency (CFF) Procedure | number of patients in whom ten measurement will be available / 30 patients | before TIPS and every 3 months till one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| occurrence of encephalopathy |  | every 3 months till one year after TIPS procedure | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cirrhosis, TIPS (Transjugular intrahepatic portosystemic shunt), Encephalopathy
Orientation Effects of Breastfeeding for Mothers

Study Overview
=================
Brief Summary
-----------------
The benefits of breastfeeding are increasingly known of the population and breastfeeding rates in the country have been increasing, but still are below satisfactory to the Ministry of Health (MH) and the World Health Organization (WHO). Simple Strategies to guide and support the mother contributes to increasing knowledge about breastfeeding and can have positive impacts on breastfeeding rates.

Detailed Description
-----------------
Assess the impact of guidance on breastfeeding duration of exclusive breastfeeding in the first six months of a baby's life. 110 pairs of mother / baby - Recruitment: Private Hospital of Porto Alegre. The first stage was carried out in the maternity - Orientation: Breastfeeding Importance Handle Correct, Positioning mother and baby, socioeconomic data and demographics. For the intervention group held three home visits: 10th day, 1st and 2nd month of the baby's life. At 6 months were made telephone contact for both groups.

Official Title
-----------------
Orientation Effects of Breastfeeding for Mothers in a Private Hospital: Randomized Controlled Trial

Conditions
-----------------
Breastfeeding

Intervention / Treatment
-----------------
* Other: Breastfeeding guidance


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Mothers living in the city of Porto Alegre Exclusion Criteria: Mothers who test positive for HIV, poor hearing, visual and mental disorders, preterm infants, twin hospitalized

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention group<br>Guidelines and review of the breastfeeding techniques. | Other: Breastfeeding guidance<br>* Breastfeeding guidance<br>|
| No Intervention: Control group<br>The control group will receive home visits only when the baby is 6 months of life, they will be re-evaluated by the researchers as the practice of exclusive breastfeeding and the technical and nursing management, and will be asked about the main difficulties encountered in maintaining breastfeeding. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effects of Breastfeeding for Mothers measured by structured questionnaire |  | Six months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Orientation, Breastfeeding
Life Style and Food Habits Questionnaire in the Portuguese Population Aged 55 or More

Study Overview
=================
Brief Summary
-----------------
The study population will be selected from the Epidemiological study on the prevalence of Age related Macular Degeneration in Portugal (Protocol N. CC-01-2009) where retinal photographic grading (current gold standard for AMD assessment) was performed to confirm AMD diagnostic. This study provides a population-based sample in which precise and contemporary information on the frequency of nutritional and lifestyle risk factors will be collected, enabling to evaluate whether the separate and/or joint effects of these factors, if found significant, are likely to have a major public health impact in terms of AMD.

Official Title
-----------------
Life Style and Food Habits Questionnaire in the Portuguese Population Aged 55 or More.

Conditions
-----------------
Age Related Macular Degeneration

Intervention / Treatment
-----------------
* Behavioral: Life style and food habits questionnaire


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subjects included in the Epidemiologic Study (Protocol N. CC-01-2009). (Subjects aged over 55 years-old included in health care units of Mira or Lousã). Written Informed Consent Form signed. Exclusion Criteria: - None

Ages Eligible for Study
-----------------
Minimum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Population of the Epidemiological study on AMD.<br> | Behavioral: Life style and food habits questionnaire<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Life style and food habits questionnaire. | Life style and food habits questionnaire. (This questionnaire assesses life style habits such as physical exercise and smoking habits and quantifies dietary intake.) | 2 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Age related macular degeneration, Food habits, Life style, Risk factors, questionnaire
Knowledge Level of Pelvic Floor in Different Age Groups

Study Overview
=================
Brief Summary
-----------------
Having knowledge and awareness about pelvic floor muscles and pelvic floor dysfunctions makes it easier for individuals to understand their own body and the treatment provided to them by healthcare professionals (Fante, 2019). In the literature, there are studies investigating the knowledge and awareness levels of different participant groups about pelvic floor and pelvic floor dysfunctions (Parden, 2016; Hill, 2017; Falvey, 2020). It has been shown that most women lack knowledge of pelvic floor muscle dysfunction, do not understand treatment options for the pelvic floor, and are unable to identify risk factors (Fante, 2019). A Pelvic Floor Health Knowledge Quiz was created by Al-Deges in order to evaluate the level of knowledge about pelvic floor and pelvic floor dysfunction in women and men in our country (Al-Deges, 2019). In line with this information, the aim of our study is to determine the level of knowledge about pelvic floor and pelvic floor dysfunctions in women and men of different age groups. The target audience of our research is male and female individuals over the age of 18, and our research will be conducted online. As a result of the information we obtained from our research, the level of knowledge of individuals living in our country about pelvic floor and pelvic floor dysfunctions will be determined and the literature will be contributed. In addition, by determining the missing information of the society about the pelvic floor, contribution will be made to the development of appropriate intervention methods in order to eliminate the deficiencies in this area and to increase the level of awareness.

Official Title
-----------------
Knowledge Level of Pelvic Floor in Different Age Groups

Conditions
-----------------
Pelvic Floor Disorders

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Female and male participants over the age of 18 Volunteering to participate in research Exclusion Criteria: Not answering all questions in the questionnaire

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pelvic Floor Health Knowledge Quiz |  | 5 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Turkey, pelvic floor,, knowledge,
Heart and Renal Failure in Hip Fracture Surgery

Study Overview
=================
Brief Summary
-----------------
Patients with acute hip fractures are old and vulnerable. With a majoriry classified as being ASA 3 or more. Frequently they receive spinal anesthesia perioperatively inducing hypotension. Even a short hypotensive period may induce postop cardiac T roponinT leakage as well as renal failure noted by Changes in Serum Creatinin or Cýstatin C This will be investigated and correlated to intraoperative hypotension as step one. Preliminary this will be followed by an intervention with vasopressor treatment perioperatively to preserve an adequte MABP

Detailed Description
-----------------
Patients with acute hip fractures are old and vulnerable. With a majoriry classified as being ASA 3 or more. Frequently they receive spinal anesthesia perioperatively inducing hypotension. Even a short hypotensive period may induce postop cardiac T roponinT leakage as awell as renal failure noted by Changes in S Creatinin or Cýstatin C This will be investigated and correlated to intraoperative hypotension as a step one. Preliminary this will be followed by an intervention with vasopressor treatment perioperatively to preserve an adequte MABP

Official Title
-----------------
Heart and Renal Failure in Hip Fracture Surgery

Conditions
-----------------
Hypotension, Hip Fractures, Renal Insufficiency, Heart Injuries

Intervention / Treatment
-----------------
* Diagnostic Test: Serum Tropinin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Hip fracture patient to be operated upon Classified as being ASA 3 or more Exclusion Criteria: Not forfilling inclusion Criterias
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Serum Tropinin|Blodsamples will be taken 4 times from preoperatively to 2 Days postoperatively|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | post surgery | 90 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum concentrations of Troponin, NTproBNP, Creatinin and Cystatin C | Relations between values and mortality at 30 and 90 days | 90 days |
Buzzy System Compared to Topical Anaesthesia During Infiltration Injection in Children.

Study Overview
=================
Brief Summary
-----------------
Aim of the study is to test the effect of Buzzy System (vibrating device) compared to topical anaesthesia on pain reduction during injection of infiltration anaesthesia in children.

Official Title
-----------------
Effect of Buzzy System (Vibrating Device) Compared to Topical Anaesthesia on Pain Reduction During Injection of Infiltration Anaesthesia in Children: A Randomized Clinical Trial Study.

Conditions
-----------------
Local Anaesthesia

Intervention / Treatment
-----------------
* Device: Buzzy System
* Drug: Topical anesthetic
* Drug: Mepecaine - L 1.8 ml carpule


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children classified as cooperative or potentially cooperative according to Wright's classification of child behaviour with rating 3 (positive) or 4 (definitely positive) according to Frankl behaviour rating scale. Children aged 5-8 years old. Patients who need maxillary buccal infiltration anesthesia. Exclusion Criteria: Children with any neurological or psychological disorders. Children with known allergy to topical or local anesthetic agents. Parental refusal for participation. Children with previous history of local anesthesia injection.

Ages Eligible for Study
-----------------
Minimum Age: 5 Years
Maximum Age: 8 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Buzzy System<br>Maxillary anesthetic infiltration injection using a conventional 2-ml syringe and a short needle after activating the buzzy device extra orally proximal to the site of injection for 30-60 seconds. | Device: Buzzy System<br>* Vibrating Device<br>Drug: Mepecaine - L 1.8 ml carpule<br>* Local dental anesthetic agent<br>|
| Active Comparator: Control<br>Maxillary anesthetic infiltration injection using a conventional 2-ml syringe and a short needle after application of 20% Benzocaine topical anesthestic gel. | Drug: Topical anesthetic<br>* 20% benzocaine gel (Opahl Topical Gel)<br>Drug: Mepecaine - L 1.8 ml carpule<br>* Local dental anesthetic agent<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain Perception during local anaesthesia injection | Pain intensity directly after the injection recorded by Wong-Baker faces pain rating scale and Faces, Legs, Arms, Crying, Consolability (FLACC) scale. | Procedure (During and immediately after the administration of local anesthesia) |
Facial Mask Tightness: A Comparative Study

Study Overview
=================
Brief Summary
-----------------
A correct preoxygenation can be obtained after a 3min delay of calm ventilation through a tight mask thereafter mask is used to make the patient breathing before intubation. Most tight masks are actually sold but they have never been compared in studies. The aim of this study is to compare air leaks with standard facial mask and QuadraLite masks during preoxygenation and induction of anesthesia.

Official Title
-----------------
Facial Mask Tightness: A Comparative Study

Conditions
-----------------
Anesthesia

Intervention / Treatment
-----------------
* Device: QuadraLite masks
* Other: standard mask


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: edentulous patients age > 55 years Exclusion Criteria: pregnancy or breast-feeding, patients on tutelage or guardianship patient unable to understand the protocol anesthesia in emergency or with full stomach

Ages Eligible for Study
-----------------
Minimum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: standard face masks<br>The standard mask is used in usual care | Other: standard mask<br> <br> |
| Experimental: QuadraLite face masks<br>This study will compare tightness of 2 face masks during preoxygenation and after induction of anesthesia with propofol, sufentanil and rocuronium. During preoxygenation, a 10 l.min-1 fresh gas flow and 8 cm H2O PEEP will be applied. After induction of anesthesia, patients will receive pressure-controlled ventilation (fresh gaz flow 3 L.min-1, pressure set to obtain a 7 ml.kg-1 ideal body weight, 10 cpm, peep 5 cm H2O). | Device: QuadraLite masks<br>* The intervention is identical in the two group<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| significant leakage (ie greater than 20% of the current volume) between QuadraLite® mask and facial mask |  | 10 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Anesthesia, facial mask
Evaluation of the Repeatability and Reproducibility of Corneal Epithelial Thickness Mapping With SD-OCT

Study Overview
=================
Brief Summary
-----------------
Evaluate the repeatability and reproducibility of the RTVue-XR for measuring the total corneal thickness (pachymetry), the epithelial thickness, and the stromal thickness mapping in normal subjects and corneal patients.

Conditions
-----------------
Repeatability & Reproducibility

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Able and willing to provide consent. Able and willing to complete required exams History of refractive surgery, contact lens, dry eye or keratoconus for corneal patients Exclusion Criteria: Unable to complete required exams History of refractive surgery, contact lens, dry eye or keratoconus for normal patients

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| epithelial thickness |  | Day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Stromal thickness |  | Day 1 |
Evaulation of Interaction Between Herbal Products and Anticoagulants

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine if the use of herbal products interferes with normal anticoagulation, leading to either excessive thinning of the blood and bleeding problems or inadequate thinning of the blood and clotting problems. Many patients who are on long term anticoagulation, or blood thinning, for a variety of medical problems, also take herbal products. It is not yet known whether use of herbal products interferes with this anticoagulation, and puts patients at risk for bleeding or clotting. This study will carefully monitor patients who are taking herbs and anticoagulants to determine if their laboratory tests show signs of being affected by the herbs. The study will ask all patients about their herbal product use, so all reported herbs will be included and monitored.

Official Title
-----------------
Early Identification of Adverse Reactions to Herbs

Conditions
-----------------
Coagulation Disorders

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Taking longer-term (>6 months) anticoagulation Enrolled in one of Kaiser Permanente Northern California anticoagulation clinics

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
side effects, herbal medicine, alternative medicines, anticoagulation, bleeding, clotting