Reducing Drug Craving Memories

Study Overview
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Brief Summary
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The primary objective is to investigate the potential ability of Inderal (propranolol hydrochloride) to diminish the reconsolidation of motivationally potent drug-related cues in cocaine dependent participants. If effective in this laboratory model, Inderal may have clinical efficacy.

Official Title
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Reconsolidation as a Treatment Target for Cocaine Addiction

Conditions
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Cocaine Addiction

Intervention / Treatment
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* Drug: Inderal


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 60 psychotropic medication-free men or women (15 subjects x 4 groups) who have met DSM-IV-TR diagnostic criteria for cocaine dependence for the past 6 months (age 18 - 50 years old); Minimum of three days cocaine abstinent on study days; Primary use of cocaine is intra-nasal or smoked crack Exclusion Criteria: Medical conditions that might be aggravated by participation in the study: cardiovascular disorders that might be aggravated by participation in the study: hypotension (SBP: < 100 mmHg), bradycardia (heart rate < 60 /min), severe atrioventricular block (Type II or III), severe hypertension (SBP: > 160 mmHg; DBP: > 100 mmHg), myocardial infarction, history of chest pain and admission to ED for chest pain; respiratory disorders: bronchial asthma and chronic obstructive pulmonary disease; diabetic patients treated with insulin or oral hypoglycemic agents. Propranolol may mask the first signs of a developing hypoglycemia. Seropositive pregnancy test Comorbidity with current axis I psychiatric disorders other than anxiety, affective and substance use disorders Severe liver disfunction Current or recent (< 5 half lives) use of medications that may interact with Inderal (see above) Positive urine tox screen for barbiturates. Positive breath alcohol screen. {Note: all urine tox screen results will be destroyed immediately after collection. The information will not be stored}

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Inderal, neutral cues<br> | Drug: Inderal<br>* Inderal vs. placebo will be administered with or without cocaine cues<br>|
| Experimental: Inderal, drug cues<br> | Drug: Inderal<br>* Inderal vs. placebo will be administered with or without cocaine cues<br>|
| Experimental: Placebo, neutral cues<br> | Drug: Inderal<br>* Inderal vs. placebo will be administered with or without cocaine cues<br>|
| Experimental: Placebo, drug cues<br> | Drug: Inderal<br>* Inderal vs. placebo will be administered with or without cocaine cues<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Self-report drug craving | One day and one month after the intervention, the investigators will measure drug craving using visual analog scales (VAS) and the Cocaine Craving Questionnaire (CCQ). | One day and one month post-treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Drug use | One month after the intervention, participants will be interviewed about their drug and alcohol use | One month after the intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cocaine addiction treatment craving