Clinical Profile in Patients With Essential Tremors

Study Overview
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Brief Summary
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Essential tremors are no longer a single motor disorder but disorder of movement associated with non-motor symptoms and the aim of this study is to explore the clinical profile of patients with essential tremors including motor and non-motor features and their relationship. and to identify clinical predictors of these features.

Detailed Description
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Essential tremors (ET) was defined as mono-symptomatic tremor syndrome involving both upper limbs during action for at least 3 years, with or without tremor in other body parts . ET is considered the most prevalent adult movement disorder, The crude prevalence of ET varies widely from 0.08 to 220 cases per 1000 persons. Many pathological post-Mortem studies are providing evidence that ET is mostly can be recognizes as neurodegenerative disease of the cerebellum and brain stem . In the last decade there is an emerging studies that discuss the presence of associated motor, non- motor, sensory and psychological symptoms besides the tremors . Motor features of ET are not confined to tremors. Another feature of ET is gait ataxia , Eye movement abnormalities of subclinical degree, difficulties in learning motor skills, Bradykinesia and slowness of finger tapping . Studies of the last two decades reported mild cognitive deficits in patients with ET in comparison to healthy controls. These deficits affect number of cognitive domains, especially verbal memory, naming, verbal fluency, attention- concentration, working memory and concept formation . In addition ET was found to be associated with hearing impairment with abnormal threshold at higher tone frequencies which refer to sensorineural hearing loss, and olfactory deficits which both may points to cochlear pathology. Moreover, patients with ET thought to have higher incidence of depression and anxiety symptoms than age-matched healthy individuals correlated with tremors severity .

Official Title
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Clinical Profile in Patients With Essential Tremors

Conditions
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Essential Tremor

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All adults Patients are fulfilling cases definition of essential tremors will be included. Gender: both sexes are included. Any patient is, able to provide informed consent including permission to obtain information from patients' clinical medical history of at least three years' duration Exclusion Criteria: Patients are diagnosed with other neurological disorders unrelated to essential tremors. Patients had any other condition presented with other cognitive or psychiatric disorders or known as drug abusers. Patient had any systemic disease presented with tremors rather than essential tremors or compliant on medication had tremors side effect.

Ages Eligible for Study
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Minimum Age: 16 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determine clinical profile including motor and non-motor features in these patients | describing the motor and non-motor associations ( cognitive , psychological and sensory )with essential tremors. | 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To identify clinical predictors of these features. | Determine the clinical predictors for these features in these ET patients and impact on their quality of life. | 3 years |