Study of Antenatal and Postnatal Data of Anorectal Malformations Diagnosed at Montpellier University Hospital Over a 10-year Period (2010-2020)

Study Overview
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Brief Summary
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Objective : Anorectal malformations (ARMs) are part of a spectrum of malformations due to an abnormal separation between the urogenital and digestive tracts during embryonic life. The prevalence of ARM is 1/2000 - 1/5000 live births, making it a relatively common malformation. The impact of an ARM depends mainly on the type of malformation, which can be difficult to evaluate in the antenatal period, and whether it is isolated or associated (50-80%) with other malformations or genetic syndromes. Only 1 to 16% of ARMs are diagnosed in the antenatal period. The objective of this study is to compare cases of prenatal diagnosis of ARM, cases of postnatal diagnosis of ARM with other antenatal ultrasound abnormalities, and those with normal antenatal ultrasound, in terms of management and functional prognosis, to identify ways to improve prenatal counseling. Materials and methods : In this retrospective monocentric study, the investigators have included all fetuses and newborns born between January 2010 and September 2020 with anorectal malformations, diagnosed from postnatal radiological examinations and surgical or autopsy reports at the University Hospital of Montpellier. The Krickenbeck classification was used to classify the ARMs and to assess the functional prognosis.

Official Title
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Study of Antenatal and Postnatal Data of Anorectal Malformations Diagnosed at Montpellier University Hospital Over a 10-year Period (2010-2020) : Why and How to Improve Antenatal Counseling ?

Conditions
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Anorectal Malformations

Participation Criteria
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Eligibility Criteria
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Inclusion criteria: fetuses and newborns born between January 2010 and September 2020 with anorectal malformations diagnosed from postnatal radiological examinations and surgical or autopsy reports at the University Hospital of Montpellier. Exclusion criteria: foreign-born patient anorectal malformation associated with an abdominal wall defect
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| antenatal diagnosis of anorectal malformation<br>Groupe 1 : antenatal diagnosis of anorectal malformation | |
| postnatal diagnosis of anorectal malfiormation with associated anomalies on antenatal ultrasound<br>Groupe 2 : postnatal diagnosis of anorectal malfiormation with associated anomalies on antenatal ultrasound | |
| postnatal diagnosis of anorectal malformation with anormal antenatal ultrasound<br>Groupe 3 : postnatal diagnosis of anorectal malformation with anormal antenatal ultrasound | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of ante or post-natal diagnosispremolars | Number of ante or post-natal diagnosis | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of with or without associated antenatal anomalies | Number of with or without associated antenatal anomalies | 1 day |