Short-term Effect of Glucose and Sacharose Ingestion on Cognitive Performance and Mood in Elderly

Study Overview
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Brief Summary
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The objective of the current study is to determine the acute effect of a glucose drink and a sacharose drink compared to a placebo on cognitive performance in elderly with light memory complaints. The investigators expect that the sugar containing drinks will improve memory and attentional functions. Furthermore, blood glucose response will be measured.

Official Title
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The Short-term Effect of Glucose and Sacharose Ingestion on Cognitive Performance and Mood in Elderly Subjects

Conditions
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Mental Health, Cognition, Memory, Attention

Intervention / Treatment
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* Dietary Supplement: glucose
* Dietary Supplement: sacharose
* Dietary Supplement: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men and women 70 years and older Memory complaints Exclusion Criteria: Type I or II diabetes Parkinson disease MMSE < 25 (to exclude cognitively impaired subjects CES-D > 16 (to exclude depressive subjects) Pharmacological antidepressives or medication for dementia Liver disease

Ages Eligible for Study
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Minimum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Drink with 50 g glucose<br>The glucose drink contains 50 g of glucose soluted in 250 ml of water and lemon juice. | Dietary Supplement: glucose<br>* The effect of a glucose solution on cognitive performance will be measured.<br>* Other names: Sucrose, sugar.;|
| Active Comparator: Drink with 100 gram of sacharose<br>The sacharose drink contains 100 g of sacharose soluted in 250 ml of water and lemon juice. | Dietary Supplement: sacharose<br>* The effect of a sacharose solution on cognitive performance will be measured.<br>|
| Placebo Comparator: Placebo with sweeteners<br>The placebo contains a mixture of artificial sweeteners in order to have the same sweetness and appearance of the test drinks (the glucose drink and the sacharose drink). | Dietary Supplement: Placebo<br>* The effect of a placebo drink with sweeteners on cognitive performance will be measured.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Performance on the paired associate recall test | Cognitive performance will be assessed by several sensitive tests. Power is calculated on the paired associate recall test, but also several other cognitive performance test focusing on memory, attention and reaction time will be performed | cognitive tests will start 15 minutes after ingestion of the intervention product | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mood | Mood will be measured by the POMS, after consuming the test drink, and after completing the congitive tests. | within 15 minutes after consuming the test drink and after completing the cognitive tests (within 90 minutes after consuming the test drink) | 
| Blood glucose response | Blood glucose will be measured at five time points, at t=0, after 15 minutes, 30, 60 and 90 minutes. | from baseline till 90 minutes after consuming the drink | 
| Plasma insulin levels | One venapunction will be carried out at baseline to measure plasma insulin levels. | At t= -15 minutes, before consuming the test drink | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cognitive performance, Attention, Memory, Glucose, Sacharose, Elderly, Memory complaints