Association of Bisphenol A,Paraben Exposure and Type 2 Diabetes

Study Overview
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Brief Summary
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The aim of this study is to evaluate the association between BPA , paraben levels and type 2 DM patients

Detailed Description
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The first phase of the study will include a questionnaire : The cases and control will be asked about demographic information such as residence, age, education, and occupation. History of discovery of diabetes. Exposure to products and materials such as polycarbonate plastics, cosmetics and beverages containing bisphenol A and paraben and it will be evaluated through exposure sheet through asking about dietary exposure, Environmental exposure and medical exposure. Then clinical evaluation including: Full clinical examination will be performed for cases and control. Anthropological data: their weights, heights and waist circumference will be measured. The body mass index (BMI) will be calculated by weight (kg)/height (m)2 formula. Investigations: routine and specific investigation as blood glucose level, HbA1c and lipid profile. Urine specimens will be collected in clean, glass containers will labeled with the subject identification number. Turbid sample or those containing blood will be excluded. All specimens will be stored frozen below 20 degree centigrade. Urine samples will be analyzed by High Performance liquid chromatograph (HPLC) to detect bispenol A and parabens levels.

Official Title
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The Possible Association Between Bisphenol A, Paraben Exposure and Type 2 Diabetic Adult Patients.

Conditions
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Type2 Diabetes, Bisphenol A

Intervention / Treatment
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* Device: HPLC


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patients ( 18 y or elder). Type 2 DM Exclusion Criteria: Type 1 DM Less than 18 y History of chronic diseases such as liver failure, cardiac patients……etc

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Case group<br>50 cases with type 2 DM. | Device: HPLC<br>* taking urine samples from participants and analyze these samples to detect bisphenol A and paraben<br>|
| Other: Control group<br>50 subjects not diabetics. | Device: HPLC<br>* taking urine samples from participants and analyze these samples to detect bisphenol A and paraben<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bisphenol A and paraben detection in urine samples of diabetic (n=50) and non diabetic persons (n=50) | Evaluation of bisphenol A and Paraben detection in urine samples from type 2 diabetic adult patients compared with non diabetic persons using HPLC | Baseline |