Treadmill and Music Cueing for Gait Training in Mild to Moderate Parkinson's Disease

Study Overview
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Brief Summary
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Sensory and motor cueing have been demonstrated as useful ambulation training techniques for Parkinson's disease (PD). This study is aimed to evaluate the effectiveness of treadmill training program with music cueing for mild to moderate PD patients.

Official Title
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Treadmill and Music Cueing for Gait Training in Mild to Moderate Parkinson's Disease: a Preliminary Study

Conditions
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Parkinson's Disease

Intervention / Treatment
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* Other: Music and treadmill walking program
* Other: Treadmill walking program
* Other: Home program


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male PD patients aged 60-80 years with Hoehn and Yahr stage 2-3 diagnosed by attending neurologist Good cognitive function with Thai Mental State Examination >23 Stable medication without freezing No prior exercise program within the last 2 months No contraindication for exercise Exclusion Criteria: Medication change during the study program Inability to walk on treadmill (in treadmill groups) Cannot complete 80% of the prescribed program

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: A<br>Treadmill with Music cueing group | Other: Music and treadmill walking program<br>* Treadmill with Music cueing training 3 days/wk, plus home music cueing 3 days/wk x 4 weeks<br>* Other names: Music cueing;|
| Active Comparator: B<br>Treadmill group | Other: Treadmill walking program<br>* Treadmill training 3 days/wk, plus home walking 3 days/wk x 4 weeks<br>* Other names: Treadmill;|
| Placebo Comparator: C<br>Home walking group | Other: Home program<br>* Home walking program 6 days/wk x 4 weeks<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Walking performance evaluated with Timed Up and Go test, walking speed, step length, and cadence. |  | within 1 week after training, and at 4 weeks follow up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Balance (single leg stance time) and fall rate |  | within 1 week after training, and at 4 weeks follow up | 
| Aerobic endurance (6 minute walk test) |  | AA) within 1 week after training, and at 4 weeks follow up | 
| Mentation, mood, behavior, Motor and ADL subscale of UPDRS |  | within 1 week after training, and at 4 weeks follow up | 
| Patient's satisfaction |  | within 1 week after training, and at 4 weeks follow up | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Parkinson's disease, Cueing training, Treadmill training, Music