Xenon Against Postoperative Oxygen Impairment

Study Overview
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Brief Summary
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Acute lung injury (ALI) is the vital complication of Stanford type A aortic dissection. It is confirmed that Xenon has the significant protective effect on important organs and has no suppression on the cardiovascular system. Furthermore, our earlier trial has already clarified that static inflation with 50% Xenon during cardiopulmonary bypass could attenuate ALI for Standford A acute aortic dissection. However the protection effect was restricted for the limited time. Aimed to enhance the protection effect of Xenon, we designed this randomized trial that anesthesia with 50% xenon one hour before and after CPB and pulmonary static Inflation with 50%,75% and 100% Xenon during CPB respectively.

Official Title
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Protection of Xenon Against Postoperative Oxygen Impairment in Adults Undergoing Stanford Type-A Acute Aortic Dissection Surgery

Conditions
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Acute Lung Injury

Intervention / Treatment
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* Other: oxygen
* Drug: Xenon


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria Consultant's clinical diagnosis of Stanford type A AAD using local pathways of diagnosis, which may include clinical history, chest radiography (X-rays), transthoracic ultrasound, and contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI) Patients aged 18 to 65 years Eligible for AAD surgery Exclusion Criteria Have coronary heart disease, heart failure, severe cardiac tamponade, unstable hemodynamics, severe nervous system abnormalities, clinically apparent malperfusion[9] including lower limb, cerebral, coronary and renal malperfusion, and visceral ischemia, sever hepatic and renal abnormalities Have undergone any of the cardiac and thoracic surgeries Are unlikely to be able to perform the required clinical assessment tasks Have significant cognitive impairment or language issues Are unable to provide consent with regard to their participation in the study Prescribed with non-steroidal anti-inflammatory drugs or corticosteroids before or after admission

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Oxygen group<br>50% oxygen inhalation one hour before and after CPB,and Pulmonary Static Inflation with 50% oxygen during CPB. | Other: oxygen<br>* 50% oxygen inhalation<br>|
| Experimental: Xenon group<br>50% oxygen inhalation one hour before and after CPB,and Pulmonary Static Inflation with 50%,75% and 100% Xenon during CPB respectively. | Drug: Xenon<br>* 50% Xenon inhalation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| oxygenation index |  | perioperative period | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| alterations in cytokine and ROS in the perioperative period |  | perioperative period | 
| extubation time |  | perioperative period | 
| complications of vital organs |  | perioperative period | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Xenon, Standford A acute aortic dissection