Effects of High-intensity Interval Training in Combination With Side-alternating Whole-body Vibration

Study Overview
=================
Brief Summary
-----------------
Investigation of the training effects following 8 weeks of high-intensity interval training (HIT)in combination with side-alternating whole-body vibration compared to conventional HIT or side-alternating whole-body vibration. The adaptations are investigated on a molecular (muscle biopsy of the M. vastus lateralis) and systemic (e.g. cycling, jumping mechanography, dynamometry) level. In addition, the acute effects of the first and last training session will be investigated on a molecular (e.g. satellite cell activation, mRNA abundance) and systemic (e.g. ventilatory ga exchange, heart rate, rating of perceived exertion) level.

Official Title
-----------------
Effects of High-intensity Interval Training in Combination With Side-alternating Whole-body Vibration

Conditions
-----------------
Health Behavior

Intervention / Treatment
-----------------
* Other: 4x4 min HIT
* Other: 4x4 min HIT + WBV (18 Hz)
* Other: 4x4 min HIT + (30 Hz)
* Other: whole-body vibration at 30 Hz


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: - male no fever / no common cold at the beginning of the study between 18 and 35 years of age non-smoker no known cardiovascular or orthopedic problems no cardiac pacemaker fullfills healts questionnaire's requirements Exclusion criteria: - female fever / common cold at beginning of study age under 18 oder above 35y smoker cardiovascular or orthopedic problems cardiac pacemaker does not fullfill health questionnaire's requirements

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 4x4 min HIT<br>Conventional 4x4 min high-intensity interval training | Other: 4x4 min HIT<br>* Conventional 4x4 min high-intensity interval training<br>|
| Experimental: 4x4 min HIT + WBV (18 Hz)<br>4x4 min high-intensity interval training in combination with whole-body vibration at 18 Hz during the active rest | Other: 4x4 min HIT + WBV (18 Hz)<br>* 4x4 min high-intensity interval training in combination with whole-body vibration at 18 Hz during the active rest<br>|
| Experimental: 4x4 min HIT + WBV (30 Hz)<br>4x4 min high-intensity interval training in combination with whole-body vibration at 30 Hz during the active rest | Other: 4x4 min HIT + (30 Hz)<br>* 4x4 min high-intensity interval training in combination with whole-body vibration at 30 Hz during the active rest<br>|
| Active Comparator: whole-body vibration at 30 Hz<br>4x3 min whole-body vibration at 30 Hz | Other: whole-body vibration at 30 Hz<br>* 4x3 min whole-body vibration at 30 Hz<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in Critical Power | The differences in changes in Critical Power [Watts] are compared between the 4 training groups. For this purpose, participants complete before and after the training intervention an incremental cycling ramp test and 4 cycling constant-load tests. | 8 weeks intervention |