A Chart Review of Newborns With the Presence of Confirmed or Suspected Maternal Chorioamnionitis and Utilization of the Early Onset Sepsis Calculator

Study Overview
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Brief Summary
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This study will review practices in relation to chorioamnionitis (CAM) before and after to the implementation of the Neonatal Early-Onset Sepsis (EOS) Risk Calculator to determine the effect in the nursery at Banner - University Medical Center Phoenix. Newborns enrolled will be at least 35 weeks gestational age (GA) and have a maternal diagnosis of at least suspected or confirmed CAM. The data will include those newborns whose assessment and treatment were not guided by the EOS calculator which was implemented on August 28, 2019 and those with which the EOS calculator was utilized. A secondary objective is to show the economic impact with utilization of the EOS calculator. Data collected will include full laboratory workups including complete blood counts (CBC), blood cultures, antibiotic usage, length of time in the newborn nursery and total length of stay.

Official Title
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A Retrospective Chart Review of Newborns With the Presence of Confirmed or Suspected Maternal Chorioamnionitis and Utilization of the Early Onset Sepsis Calculator

Conditions
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Maternal; Chorioamnionitis, Affecting Fetus, Early-Onset Sepses, Neonatal

Intervention / Treatment
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* Diagnostic Test: EOS Calculator


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Asymptomatic newborns 35 weeks or greater GA born at Banner - University Medical Center Phoenix whose mothers were determined or suspected to have CAM. Exclusion Criteria: Direct NICU Admissions Subjects may be excluded at Investigator discretion

Ages Eligible for Study
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Minimum Age: 35 Weeks

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sample<br>Asymptomatic newborns 35 weeks or greater GA born at Banner - University Medical Center Phoenix whose mothers were determined or suspected to have CAM. | Diagnostic Test: EOS Calculator<br>* Neonatal Early-Onset Sepsis Risk Calculator which is a tool that determines the risk of EOS for a particular newborn by looking at maternal risk factors and the newborn's clinical picture as opposed to just laboratory tests alone<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To determine whether the usage of Neonatal EOS Calculator decreased antibiotic usage in newborns with a maternal diagnosis of suspected or confirmed chorioamnionitis (CAM) in our newborn nursery. | To determine the usage of EOS Calculator measuring decreased antibiotic usage. | August 28, 2018 through August 28, 2020 | 
| To determine whether the usage of Neonatal EOS Calculator measuring laboratory testing in newborns with a maternal diagnosis of suspected or confirmed chorioamnionitis (CAM) in our newborn nursery. | To determine the usage of EOS Calculator measuring laboratory testing. | August 28, 2018 through August 28, 2020 | 
| To determine whether the usage of Neonatal EOS Calculator LOS in newborns with a maternal diagnosis of suspected or confirmed chorioamnionitis (CAM) in our newborn nursery. | To determine the usage of EOS Calculator measuring length of stay (LOS) in newborns | August 28, 2018 through August 28, 2020 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To evaluate the economic impact after the implementation of the EOS Calculator in antibiotic usage in newborn nursery and total length of hospital stay. | Evaluate the economic impact after the implementation of the EOS Calculator in antibiotic usage. | August 28, 2018 through August 28, 2020 | 
| To evaluate the economic impact after the implementation of the EOS Calculator in laboratory tests in newborn nursery and total length of hospital stay. | Evaluate the economic impact after the implementation of the EOS Calculator in laboratory tests. | August 28, 2018 through August 28, 2020 | 
| To evaluate the economic impact after the implementation of the EOS Calculator in LOS in newborn nursery and total length of hospital stay. | Evaluate the economic impact after the implementation of the EOS Calculator LOS in newborn nursery and total length of hospital stay. | August 28, 2018 through August 28, 2020 |