Pediatric Pertussis in Ambulatory Settings

Study Overview
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Brief Summary
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Since 2002, Whooping cough surveillance in pediatric private practice has been set up in France. The results of the first years, 2002-2006, have confirmed the effectiveness of the Pertussis whole-cell (Pw) vaccine and in particular the duration of protection of 9/10 years. After evaluating cases in children vaccinated with Pw vaccines, the study aims today to analyze cases in children vaccinated with Pertussis acellular (Pa) vaccines used since 2002/2003 and to assess, on an outpatient basis, the impact of new vaccine recommendations in France (in 2013, introduction of a 2 + 1 schedule - 8 weeks, 4 months and a 11-month recall - and a 6-year recall, and in 2014, update in the recommendations of exams to be prescribed based on the child's age and vaccination status).

Detailed Description
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The whooping cough surveillance objectives are : to follow the duration of protection of the Ca vaccines in the context of modifications of the vaccine recommendations to describe the clinical characteristics of a population vaccinated with several boosters to adapt complementary examinations for diagnostic purposes (culture, PCR, serology) according to the evolution of scientific knowledge to monitor B. parapertussis infections to train laboratories with nasopharyngeal aspiration to monitor the evolution of the bacterial species All children aged 0-18 years, in whom the diagnosis of pertussis is mentioned and for which a biological check-up is requested, are included, except asymptomatic children with confirmed family case. In case of suspected pertussis, real-time PCR and / or culture and / or (rarely) serology is / are still prescribed to the patient and / or his entourage. Selected Pediatricians from the ACTIV group and the AFPA working in an outpatient clinic, located in different places in France, are participating in this network since 2001. The clinical evolution and the results of the examinations are transcribed on a case report form. The data are collected, firstly, during the visit where the diagnosis of whooping cough is suspected and a biological assessment requested (patient's medical history, clinical data, vaccination status and dates, as well as the search for a contaminated/contaminator) and secondly during the follow-up visit (results of the biological check-up and diagnosis, antibiotics potentially prescribed, and supplement data of the entourage, except in case of diagnosis of pertussis not retained). All evaluations made by the pediatricians are regularly reviewed during meetings, and final diagnoses used are: biological pertussis epidemiological pertussis not evaluable lost of follow up no whooping cough

Official Title
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National Surveillance of Pediatric Pertussis in Ambulatory Settings

Conditions
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Pertussis/Whooping Cough, Children, Only, Ambulatory

Intervention / Treatment
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* Other: non interventional study


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All children under 18 years old with a pertussis diagnosis is suspected and a biological exam is requested Exclusion Criteria: children without symptoms with a household confirmed case cases for which the pertussis diagnosis was not suspected by the pediatrician

Ages Eligible for Study
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Minimum Age: 1 Day
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: non interventional study|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of pertussis vaccines protection | Evaluate the duration of protection of the Ca vaccines | at inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical characteristics of pertussis | Describe the clinical characteristics of a population vaccinated | at inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pertussis, surveillance, pertussis acellular vaccine