TEMporal PostOperative Pain Signatures

Study Overview
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Brief Summary
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The purpose of this research study is to determine what causes pain after surgery to increase or decrease over time.

Detailed Description
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Before surgery, study participants will be asked questions about age, gender, race/ethnicity, annual income, and education level. Study participants will also be questioned regarding prior pain experiences, their mood and how they think about pain. A small test tube of blood, a cheek swab or a saliva sample will be taken to see what genetic differences may influence individuals pain after surgery. After surgery, study participants will be asked questions about their pain intensity while in the hospital. Additional information will be collected about the effects of pain medicine, and their recovery from surgery. Following discharge from the hospital, study participants will be contacted monthly to confirm continued communication. Study participants will also be contacted six months after surgery, and asked to complete a final survey about their pain after surgery.

Official Title
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Finding Good TEMporal PostOperative Pain Signatures (TEMPOS)

Conditions
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Pain, Postoperative

Intervention / Treatment
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* Behavioral: Surgical patients' clinical progression
* Genetic: Genetic markers


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 years of age or older anticipated length of hospital stay of 72 hours or greater expected post-operative survival greater than 6 months Exclusion Criteria: < 18 years of age anticipated need for prolonged post-operative intubation (greater than 24 hours) urgent or emergent surgical procedure inability to understand or participate in questionnaires, surveys or data collection

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Surgical patients' clinical progression<br>Patients undergoing non-ambulatory surgery will be asked questions and complete surveys in an effort to characterize postoperative pain experience profiles. A blood sample will be obtained for genetic markers exploring a variety of pain-related genes. | Behavioral: Surgical patients' clinical progression<br>* Study the dynamic nature of pain<br>Genetic: Genetic markers<br>* Research variants in genes related to pain sensitivity, analgesic sensitivity and opioid response<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measure postoperative pain scores change with respect to time | Pain scores will be measured using previously established pain scale and Questionnaire | up to 7 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measure variables that contribute to postoperative pain scores | Variables: clinical, biological, psychological, and social factors | up to 6 months | 
| Measure timing patterns that may influence development of persistent postsurgical pain (PPP) | Different patterns of pain analgesia-pain cycles | up to 6 months | 
| Genetic testing | Specific single nucleotide polymorphisms | up to 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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postoperative pain, surgery, pain resolution, pain intensity, persistent postsurgical pain, pain-related genes, analgesic