Effect of Radiofrequency Ablation in Patients With Ventricular Arrhythmia Undergoing CABG

Study Overview
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Brief Summary
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Patients with myocardial infarction related potential malignant ventricular arrhythmia have high risk of sudden death. The aim of this clinical trial is evaluating therapeutic efficacy of unipolar or bipolar radiofrequency ablation in Coronary Artery Bypass Grafts (CABG) Surgery, which can reduce myocardial ischemia and block reentry circuits of ventricular arrhythmia at the same time. The observation indexes include the morbidity of potential malignant ventricular arrhythmia and major adverse cardiovascular events in mid-long-term after CABG surgery.

Official Title
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Impact of Radiofrequency Ablation Therapy in Coronary Artery Bypass Grafts Surgery on Outcomes in Patients With Myocardial Infarction Related Ventricular Arrhythmia

Conditions
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MI Related Malignant Ventricular Arrhythmia

Intervention / Treatment
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* Procedure: unipolar or bipolar radiofrequency ablation+CABG
* Procedure: CABG


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The patients have been receiving coronary artery bypass grafts from 2015.1-2017.12 The patients had old myocardial infarction related potential malignant ventricular arrhythmia Anti-arrhythmic drug treatment is invalid All enrolled patients must being signed the informed consent Exclusion Criteria: Severe heart failure( ejection fraction under 35%) Patients with acute myocardial infarction Patients with ICD implanted

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: control group<br>Patients with myocardial infarction related potential malignant ventricular arrhythmia undergoing Coronary Artery Bypass Grafts | Procedure: CABG<br>* Patients with myocardial infarction related potential malignant ventricular arrhythmia undergoing Coronary Artery Bypass Grafts<br>|
| Experimental: interventional group<br>Patients with myocardial infarction related potential malignant ventricular arrhythmia undergoing unipolar or bipolar radiofrequency ablation and Coronary Artery Bypass Grafts at the same time | Procedure: unipolar or bipolar radiofrequency ablation+CABG<br>* Patients with myocardial infarction related potential malignant ventricular arrhythmia undergoing unipolar or bipolar radiofrequency ablation and Coronary Artery Bypass Grafts at the same time<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Morbidity of potential malignant ventricular arrhythmia | The morbidity of potential malignant ventricular arrhythmia in 1 year after surgery | 1 year after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Morbidity of major adverse cardiovascular events | The morbidity of the major adverse cardiovascular events in 1 year after surgery | 1 year after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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myocardial infarction, ventricular arrhythmia, radiofrequency ablation, Coronary Artery Bypass Grafts