Appearance of Far Peripheral Retina in Normal Eyes by Ultra-widefield Fluorescein Angiography

Study Overview
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Brief Summary
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PURPOSE: To characterize the appearance of the far peripheral retina of normal eyes using ultra-widefield fluorescein angiography (UWFA). DESIGN: Prospective observational case series. METHODS: This study enrolled normal eyes with best corrected visual acuity ≥ 20/20, refractive error < 3.00D, and without visible retinal pathologic changes under a slit lamp-based condensing lens. The far peripheral retina was detected by UWFA. Ciliary body thickness (CBT) at 3 mm (CBT1) and 2 mm (CBT2) posterior to the scleral spur was measured by ultrasound biomicroscopy.

Detailed Description
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PURPOSE: To characterize the appearance of the far peripheral retina of normal eyes using ultra-widefield fluorescein angiography (UWFA). DESIGN: Prospective observational case series. METHODS: This study enrolled normal eyes with best corrected visual acuity ≥ 20/20, refractive error < 3.00D, and without visible retinal pathologic changes under a slit lamp-based condensing lens. Demographic and clinical data such as age, sex, and reasons for undergoing FA were collected. The far peripheral retina was detected by UWFA. The fundal fields obtained using the Heidelberg ultra-widefield lens in a single shot and in montage images were compared with those acquired using the Heidelberg conventional 55° lens. The signs at the peripheral retina detected by UWFA were described and grouped. Ciliary body thickness (CBT) at 3 mm (CBT1) and 2 mm (CBT2) posterior to the scleral spur was measured by ultrasound biomicroscopy.

Official Title
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The Director of the Fundus Center of Zhongshan Ophthalmic Center

Conditions
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Normal Eyes, Peripheral Retina

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: best corrected visual acuity ≥ 20/20 refractive error < 3.00D without visible retinal pathologic changes under a slit lamp-based condensing lens Exclusion Criteria: history of ocular surgery presence of ocular or systemic diseases opacity of refractive media, which interfered with the peripheral retina image quality

Ages Eligible for Study
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Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1 (MB- and VL-)<br>without mottled fluorescent band (MB) and vascular leakage (VL) | |
| 2 (MB+ and VL-)<br>with mottled fluorescent band (MB), without vascular leakage (VL) | |
| 3 (MB-/+ and VL+)<br>with or without mottled fluorescent band (MB), with vascular leakage (VL) | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ultra-widefield fluorescein angiography findings at the far peripheral retina of normal eyes |  | from November 2014 to January 2016 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ciliary body thickness |  | from November 2014 to January 2016 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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normal eyes, ultra-widefield fluorescein angiography, peripheral retina