Perfusion and Dual Energy Computer Tomography in Hepatocellular Carcinoma

Study Overview
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Brief Summary
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The aim of this study is to evaluate the hepatic perfusion computer tomography and dual energy computer tomography in the assessment of tumor characterization of Hepatocellular carcinoma in patients with resectable Hepatocellular carcinoma by comparing the quantitative parameters computer tomography obtained with the pathological data of the surgical specimens.

Detailed Description
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Dual-energy computer tomography and perfusion computer tomography (General Electric revolution Hight definition Gemstone™ Spectral Imaging) will be performed in all patients. Iodine concentration and quantitative perfusion parameters of the Hepatocellular carcinoma and surrounding liver parenchyma data will be compared with the pathological results.

Official Title
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Prediction Value of Perfusion and Dual Energy Computer Tomography for Microvascular Invasion in Hepatocellular Carcinoma

Conditions
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Hepatocellular Carcinoma

Intervention / Treatment
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* Radiation: perfusion Computed Tomography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: A diagnosis of Hepatocellular carcinoma made according to the guidelines of the American Association for the study of the Liver Affiliation to a national health insurance An indication for hepatic resection during the decision-making stage A request for a pre-operative Computer Tomography in our radiology unit An affiliation to a social security Informed consent given by the patient Exclusion Criteria: Previous treatments of Hepatocellular carcinoma (medicated or surgical) Patient under tutorship or curatorship Pregnant or lactating woman

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Interventional Model Description: Dual-energy computed tomography and perfusion computed tomography
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: perfusion computed tomography<br>Will be realsed before liver surgery | Radiation: perfusion Computed Tomography<br>* Will be carried before liver surgery<br>* Other names: Computed tomography;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pefusion parameters | correlation between pre-operative imaging data and histological data of Hepatocellular carcinoma | 5 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pathological examination | Compare data obtained in perfusion computer tomography to the imaging data and to the Histological differentiation grades | 1 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Perfusion computer tomography, dual-energy computer tomography