Assessment of Histologic Prognostic Factors in Peritoneal Malignant Mesothelioma

Study Overview
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Brief Summary
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Malignant peritoneal mesothelioma is a rare neoplasm. The most common type, the epithelioid type, has been further divided into histological patterns of tubulo-papillary, acinar, adenomatoid, micropapillary, or solid. Its prognosis is improved by the use of a locoregional treatment combining extensive cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), which increases survival up to 50 months. Histology is one of the most important prognostic variable that, forms the basis for treatment decisions. However, the prognostic of the epithelioid type varies greatly due to its tumor heterogeneity. It is therefore necessary to find prognostic factors of malignant epithelioid peritoneal mesothelioma in order to better define the therapeutic strategy. Among histological factors, solid growth, tumor necrosis, nuclear atypia, and mitotic count were found to be independent prognostic factors in epithelioid malignant pleural mesothelioma. However, in epithelioid malignant peritoneal mesothelioma (EMPM), these factors were studied in small and heterogeneous series in terms of histological growth and definitions used for histological factors. The present large study was conducted to investigate the prognostic impact of several histologic factors in EMPM. Their prognosis impacts were assessed using overall survival (OS) and progression-free survival (PFS) in EMPM.

Official Title
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Assessment of Histologic Prognostic Factors in Peritoneal Malignant Mesothelioma

Conditions
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Peritoneal Malignant Mesothelioma

Intervention / Treatment
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* Other: No intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - peritoneal malignant mesothelioma Exclusion Criteria: opposition to reuse personnal data

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| peritoneal malignant mesothelioma of grade 1<br>peritoneal malignant mesothelioma of grade 1 | Other: No intervention<br>* No intervention<br>|
| peritoneal malignant mesothelioma of grade 2<br>peritoneal malignant mesothelioma of grade 2 | Other: No intervention<br>* No intervention<br>|
| peritoneal malignant mesothelioma of grade 3<br>peritoneal malignant mesothelioma of grade 3 | Other: No intervention<br>* No intervention<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assessment of pronostic impact of nuclear grade in comparison with combined grade in peritoneal malignant mesothelioma | Assessment by the review of pathologists | 3 months to 4 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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peritoneal malignant mesothelioma, mesothelioma, prognostic factors