Brown Fat Activity and White Fat Accumulation

Study Overview
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Brief Summary
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White and brown adipocytes differ in their expression of hormones, cytokines, and inflammatory factors, and they modulate different biological functions. While white adipose tissue (WAT) serves as the primary site of energy storage, brown adipose tissue (BAT) instead metabolizes fat to produce heat and regulate body temperature. BAT is likely present in all humans, but the low prevalence of BAT depiction in adults and elderly subjects has hindered longitudinal assessments of the relation between BAT activity and WAT. Under typical imaging conditions, BAT is detected more frequently in children and teenagers than in adults with malignancy. Since most children with cancer have significantly shorter treatment courses and greater survival rates compared to adult patients, the investigators have the ability to examine the relation of repeated measures of body composition and BAT by selecting pediatric patients. In this study, the investigators will longitudinally examine whether BAT activity is related to changes in weight and the amounts of SAT, VAT, and abdominal muscle in children successfully treated for pediatric cancer.

Official Title
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Study on the Association Between Brown Adipose Tissue Activation and White Adipose Tissue Accumulation in Successfully Treated Pediatric Malignancy

Conditions
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Hodgkins Lymphoma, Non-hodgkins Lymphoma

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients had PET/CT scans with evidence of malignant disease Patients had no metabolically active BAT at diagnosis on their PET/CT scan Patients were disease free within 1 year of diagnosis Exclusion Criteria: Patients had PET/CT scans with no evidence of malignant disease Patients with metabolically active BAT at diagnosis on their PET/CT scan Patients were not disease free within 1 year of diagnosis

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Malignant Disease with no visualized BAT<br>Children 18 years or younger who 1) had PET/CT scans with evidence of malignant disease but no metabolically active brown adipose tissue (BAT) at diagnosis and 2) were disease free within 1 year of diagnosis. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from Baseline in Subcutaneous Adipose Tissue Volume at Follow-up |  | Baseline and up to 1 year | 
| Change from Baseline in Visceral Adipose Tissue Volume at Follow-up |  | Baseline and up to 1 year | 
| Change from Baseline in Presence of Brown Adipose Tissue |  | Baseline and up to 1 year | 
| Change from Baseline in Abdominal Musculature Volume |  | Baseline and up to 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from Baseline in Anthropometric Measures at Follow-up | Age, height, weight and BMI | Baseline and up to 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Brown adipose tissue