Exertional Rhabdomyolysis- Characterization of Prediction Tests for Return to Duty

Study Overview
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Brief Summary
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In order to determine norm values for skeleton muscle disassembly due to physical exertion in healthy and trained population, and developing a prediction test for approval for rhabdomyolysis injuries to return to duty, 50 healthy subjects will undergo a series of different physical tests.

Detailed Description
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50 healthy civilians volunteers will be recruited for this study. Each subject will undergo the physical tests: anthropometric measurements, wingate test, VO2max test, step test and running on the anaerobic threshold, on separate days. Blood sample, lactic acid level (measured in blood drop - finger sting) and urine sample will be taken before and after every test.

Official Title
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Exertional Rhabdomyolysis- Characterization of Prediction Tests for Return to Duty

Conditions
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Rhabdomyolysis

Intervention / Treatment
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* Other: physical tests


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy civilians ages 18-30. above average aerobic and anaerobic fitness. Without heart, cardiovascular, metabolic or respiratory illnesses. Without known medical illness or medication use that might endanger the participants. Exclusion Criteria: existence of any of undesired conditions detailed in the inclusion criteria. the physician decision.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: experimental protocol<br>50 healthy, male, trained and aged 18-30 will be recruited and asked to undergo a series of physical tests. | Other: physical tests<br>* each subject will undergo the following physical tests: day 1 - anthropometric measurements, wingate test and after 1 hour rest VO2max test. lactic acid levels will be measured before and after both tests. day 2 - step test day 3 - running on the anaerobic threshold. blood sample, lactic acid level (measured in blood drop - finger sting) and urine sample will be taken before and after every test in days 2 and 3.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| creatine phosphokinase (CPK) | CPK is a marker for muscle damage assessed in blood test. blood sample will be taken before and after step test and running on the anaerobic threshold test. | 5 experiment days for each subject | 
| oxygen consumption (VO2) | VO2 will be monitored continuously using a metabolic system (ERGOTEST 680, ZAN, GERMANY ) during VO2max test, step test and running on the anaerobic threshold test. | 5 experiment days for each subject | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| lactic acid | lactic acid level is assessed from blood drop (finger sting), will be taken before and after every test. lactic acid is a marker for anaerobic effort evaluating. | 5 experiment days for each subject | 
| Myoglobin | marker from urine sample, taken before and after step test and running on the anaerobic threshold test. | 5 experiment days for each subject | 
| Heart rate | The heart rate will be monitored using a wearable heart rate monitor (Polar® sensor and heart rate monitor watch). | 5 experiment days for each subject |