Hyaluronic Acid With Scaling & Root Planing In Chronic Periodontitis Patients With Diabetes Mellitus Type 2

Study Overview
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Brief Summary
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The present study aimed to assess the adjunctive use of Hyaluronic acid with scaling & root planing (SRP) in patients with chronic periodontitis & diabetes mellitus type 2.

Detailed Description
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Thirty subjects with chronic periodontitis & diabetes mellitus type 2 were included in this randomized clinical trial. These subjects were randomly allocated into test & control equal groups. The test group comprised fifteen patients who received SRP with subgingival application of Hyaluronic acid as an adjunct. The control group included fifteen patients who received SRP alone. Plaque index (PI), gingival index (GI), probing depth (PD) & clinical attachment level (CAL) were measured & documented at baseline, 6 weeks & 12 weeks intervals.

Official Title
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Adjunctive Use Of Hyaluronic Acid With Scaling & Root Planing In Treatment of Chronic Periodontitis Patients With Diabetes Mellitus Type 2: A Randomized Controlled Trial

Conditions
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Chronic Periodontitis

Intervention / Treatment
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* Procedure: Periodontal treatment with Hyaluronic acid associated with SRP
* Procedure: Scaling & root planning alone


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with chronic periodontitis and type 2 diabetes mellitus Minimum of 20 teeth Clinical attachment level (CAL) ≥ 3 mm Probing depth (PD) ≥ 4 mm. Exclusion Criteria: Pregnant females Smokers

Ages Eligible for Study
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Minimum Age: 38 Months
Maximum Age: 56 Months

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: SRP group<br>Chronic periodontitis patients with type 2 diabetes mellitus recieved Periodontal treatment in the form of scaling & root planing (SRP) alone. | Procedure: Scaling & root planning alone<br>* Patients received full-mouth supra- & sub-gingival SRP with the use of ultrasonic device & periodontal universal & Gracey curettes under local anesthesia.<br>|
| Experimental: Hyaluronic acid & SRP group<br>Chronic periodontitis & type 2 diabetes mellitus patients received Periodontal treatment in the form of scaling & root planing (SRP) with the adjunctive use of hyaluronic acid. | Procedure: Periodontal treatment with Hyaluronic acid associated with SRP<br>* In addition to SRP, patients in the test group received adjunct subgingival application of hyaluronic acid in all selected periodontal pockets.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gain in clinical attachment level | Gain in clinical attachment level will be measured in millimeter by William's graduated periodontal probe | 12 weeks |