Imminently Effect of Interval Training With High Intensity (HIT) After Heart Transplantation

Study Overview
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Brief Summary
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High intensity Interval training (HIT) has repeatedly been documented to have superior positive effects on oxygen uptake and general physical health compared to continuous moderate exercise in healthy individuals and patients with heart disease. Recently, the same effect has been shown in heart transplanted recipients. Which mechanisms that explains this difference is uncertain; the effect can be due to changes in the heart or changes in the peripheral tissue and muscles. To explore these mechanisms the investigators will in this study compare two different exercise modalities, and explore how different biomarkers change in blood, related to exercise.

Detailed Description
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15 heart transplanted recipients (and 5 healthy controls) will be included in the study. Each patient will have three study-days. The study is designed to be a cross-over study. And randomisation will decide which training they will have som training session 1 and training session 2; Interval or continuous training. Before starting the two training sessions they will measure oxygen uptake and baseline blood samples. During each exercise session the patients will take blood samples during and after exercise. After first study admission the patients will have a wash out period for 1 week until first training session, and another week until the last session.

Official Title
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Changes in Blood Measured Before, During and After Exercise in Heart Transplant Recipients. Imminently Effect of Interval Training With High Intensity Compared With Continuous Moderate Intensity

Conditions
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Heart Transplantation

Intervention / Treatment
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* Other: interval training
* Other: moderate exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria (HTx): 1-10 years after heart transplantation Lives in Oslo or near Oslo Stable health condition Optimal medical treatment/ medication No limiting physical handicap Written consent Inclusion healthy control: No verified heart disease Willing to preform the study Over 18 years Written consent Exclusion Criteria: Under 1 year or over 10 year since HTx. Lives far from Oslo Unstable health condition Not optimal medical treatment and/ or medication Limiting physical handicap Under 18 years Not written consent

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: HTx<br>Heart transplant recipients n=15 | Other: interval training<br>* 4 intervals with high intensity on treadmill, and approximately 3 minutes rest between intervals.<br>Other: moderate exercise<br>* 30 minutes (moderate intensity) aerobic exercise on treadmill without rest.<br>|
| Active Comparator: Control<br>Healthy controls n=5 | Other: interval training<br>* 4 intervals with high intensity on treadmill, and approximately 3 minutes rest between intervals.<br>Other: moderate exercise<br>* 30 minutes (moderate intensity) aerobic exercise on treadmill without rest.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in crp with interval training compared to moderate training |  | 1 week | 
| Changes in interleukin levels with interval training compared to moderate training |  | 1 week | 
| Changes in ICAM levels with interval training compared to moderate training |  | 1 week | 
| Changes in MiRNA levels with interval training compared to moderate training |  | 1 week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Questionnaire of quality of life |  | baseline | 
| Oxygen uptake | V02 peak measured på exercise test on treadmill. | baseline | 
| Questionnaire of physical activity |  | baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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exercise test, biological markers