Assessing Dietary Requirements in Relation to Resting Metabolic Rate in Spinal Cord Injury

Study Overview
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Brief Summary
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Assess the relationship between body composition, metabolism, and dietary needs in people with spinal cord injury compared to their healthy controls that are age and sex matched.

Detailed Description
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This study will quantify body composition and resting metabolic rate and then compare these parameters to results from a nutritional analysis. Participants will have two study visits that include physical exam, blood draws, resting metabolic rate, Dual Energy X-ray Absorptiometry (DXA) scan, and dietary assessments.

Official Title
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Assessing Dietary Requirements in Relation to Resting Metabolic Rate in Spinal Cord Injury

Conditions
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Dietary Habits, Spinal Cord Injuries

Intervention / Treatment
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* Diagnostic Test: Resting Metabolic Rate
* Diagnostic Test: Body Composition
* Behavioral: Dietary Assessment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1. C4-L2 motor complete (AIS A & B) Spinal Cord injury for duration greater than 12 months. 4. <5% change in body in body weight over the past 12 months 5. Fluent in written and spoken English Exclusion Criteria: <22% body fat Coronary artery disease Type 1 diabetes mellitus, insulin-requiring Type 2 or untreated diabetes mellitus (fasting glucose>126 or HgbA1c>7.0) Hypothyroidism, and/or renal disease Decisional impairment Prisoner

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Spinal Cord Injury Group<br>Body Composition, Resting Metabolic Rate, and dietary assessment | Diagnostic Test: Resting Metabolic Rate<br>* 30 minute test to determine daily caloric needs<br>Diagnostic Test: Body Composition<br>* Total Body DXA scan to determine fat mass, fat-free mass, and percent body fat<br>Behavioral: Dietary Assessment<br>* Self administered dietary logs<br>|
| Healthy Controls<br>Body Composition, Resting Metabolic Rate, and dietary assessment | Diagnostic Test: Resting Metabolic Rate<br>* 30 minute test to determine daily caloric needs<br>Diagnostic Test: Body Composition<br>* Total Body DXA scan to determine fat mass, fat-free mass, and percent body fat<br>Behavioral: Dietary Assessment<br>* Self administered dietary logs<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of Body fat |  | Week 2 | 
| Fat Free Mass | lbs | Week 2 | 
| Fat Mass | lbs | Week 2 | 
| Resting Metabolic Rate |  | Week 2 | 
| Dietary Assessment Using Self-Reported Diary Questionaire | Dietary information will be collected from the participants using a self-reported food frequency diary questionnaire. The diary will log food, amount eaten, how it was prepared, and brand name of participant food intake at breakfast, lunch, snacks, and dinner. | Week 2 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Resting Metabolic Rate