Graphene Oxide in the Surgical Management of Intrabony Periodontal Defects

Study Overview
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Brief Summary
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Using Graphene oxide in the surgical management of periodontal intrabony defects.

Detailed Description
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Evaluation of the effect of Graphene oxide in the surgical management of periodontal intrabony defects in animals in periodontal clinical parameters with histomorphometric evaluation .

Official Title
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Graphene Oxide in the Surgical Management of Intrabony Periodontal Defects: A Randomized Experimental Study With Histomorphometric Analysis

Conditions
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Periodontal Diseases

Intervention / Treatment
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* Procedure: Graphene oxide and open flap debridement
* Procedure: Open flap debridement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: male dogs 12-24 months old with approximate weight of 20-30 kg and general good health will be used Exclusion Criteria: -

Ages Eligible for Study
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Minimum Age: 1 Year
Maximum Age: 2 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Graphene oxide group<br>The surgical defect will be managed by open flap debridement and application of Graphene oxide | Procedure: Graphene oxide and open flap debridement<br>* Using Graphene oxide with open flap debridement in management of periodontal intrabony defects in dogs<br>|
| Other: Open flap group<br>The surgical defect will be managed by open flap debridement | Procedure: Open flap debridement<br>* Using Open flap debridement in management of periodontal intrabony defects in dogs<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| periodontal probing depth | To evaluate the use of Graphene Oxide in the surgical management of intrabony periodontal defects regarding the changes in periodontal probing depth measured in mm  using University of North Carolina periodontal probe( UNC 15 probe ). | 2 months | 
| Clinical attachment level | To evaluate the use of Graphene Oxide in the surgical management of intrabony periodontal defects regarding the changes in clinical attachment level measured in mm  using University of North Carolina periodontal probe( UNC 15 probe ) | 2 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Histomorphometric evaluation | To evaluate the use of Graphene Oxide in the surgical management of intrabony periodontal defects using histological sections obtained from the surgical site to do quantitative assessment of bone remodeling, modeling, and structure by counting the number of osteoblasts and the number of bone trabeculae  using computer based microscope and software. | 2 months |