Impact of Bariatric Surgery on Epicardial Adipose Tissue and on Myocardial Function

Study Overview
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Brief Summary
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Growing evidence suggests that bariatric surgery is a relevant treatment for severely obese patients, especially those with metabolic complications, as it significantly reduces weight, hypertension and ameliorates glycemic control. Its action on adipose tissue distribution and in particular on epicardial adipose tissue EAT remains unknown. Whether metabolic improvement is associated with EAT reduction is also unknown. The researchers thus investigated the effect of bariatric surgery on EAT in severely obese patients. The primary endpoint of this study was the change in EAT amount 6 months after bariatric surgery.

Detailed Description
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The best of our knowledge, no study has really addressed whether this EAT was modulated by diet or therapeutics like bariatric surgery. The researchers were particularly interested in studying the impact of bariatric surgery and of weight loss on the amount of EAT and whether reduction in EAT could have a positive impact on myocardial function.

Official Title
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Impact of Bariatric Surgery on Epicardial Adipose Tissue and on Myocardial Function

Conditions
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Severely Obese Patients

Intervention / Treatment
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* Procedure: bariatric surgery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: men or women who have more than 18 years patients have been informed and have consented severely obese patients with surgery indication Exclusion Criteria: contraindications at surgery, at MNR imagery History of infarct, of congenital cardiomyopathy Treatment modifying the distribution of the fat Pregnant or breast-feeding women patients less than 18 years Patient without consentment

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: severely obese patients<br>35 patients addressed for severe obesity in the Endocrinology department of Marseille North Hospital before (V1) and 6 months (V2) after bariatric surgery | Procedure: bariatric surgery<br>* The bariatric surgery is a relevant treatment for severely obese patients those with metabolic complications, as it significantly reduces weight, hypertension and ameliorates glycemic control.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The change in EAT amount 6 months after bariatric surgery. | We thus investigated the effect of bariatric surgery on EAT in severely obese patients. | 36 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of 3 parameters | to evaluate the variation in myocardial, hepatic , pancreatic and triglyceride content to evaluate the variation in left ventricular function or myocardial function and to describe the relationships between changes in visceral abdominal fat, subcutaneous fat and epicardial fat | 36 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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severely obese patients