linjc16/ctgov huggingface dataset:
A Prospective Clinical Trial Comparing Serum Mast Cell Tryptase (SMCT) Levels to Arthrofibrosis Rates Among Primary Total Knee Arthroplasty (TKA) Patients

Study Overview
=================
Brief Summary
-----------------
This research is being done to see if the amount of an enzyme in blood (called serum mast cell tryptase) changes before and after surgery. The investigators would like to see if these amounts are related to knee stiffness and pain in subjects that undergo a total knee replacement.

Official Title
-----------------
A Prospective Clinical Trial Comparing Serum Mast Cell Tryptase (SMCT) Levels to Arthrofibrosis Rates Among Primary Total Knee Arthroplasty (TKA) Patients

Conditions
-----------------
Knee Osteoarthritis, Arthropathy of Knee, Arthrofibrosis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Investigators will include all patients with osteoarthritis who are surgical candidates for primary TKA. Investigators will include all eligible male or female patients between the ages of 20 years to 100 years old. All included study participants must be able to give an informed consent. Exclusion Criteria: Significant femoral or tibial deformity due to congenital or traumatic etiologies, inflammatory arthritis, post-septic arthritis, osteomyelitis, prior infection of knee joint, osteoporosis, dislocated or fragmented patella Patients taking mast cell inhibitors and/or degranulation inhibitors for any reason. The presence of infections, highly communicable diseases (e.g. AIDS), active tuberculosis, venereal disease, hepatitis. Significant neurological or musculoskeletal disorders or disease that may adversely affect normal gait or weight bearing. Presence of previous prosthetic knee replacement devices (of any type) Metastatic disease Psychiatric illness Drug or alcohol abuse Inability to participate in standard postoperative rehabilitation protocol

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| SMCT values | Serum mast tryptase values will be assessed post-operatively | 1 year |
Institut Paoli Calmettes Hepatic Surgery Database

Study Overview
=================
Brief Summary
-----------------
Database of patients who undergo hepatic surgery for: benign diseases, primary or secondary liver cancer at Institut Paoli-Calmettes

Official Title
-----------------
Institut Paoli Calmettes Hepatic Surgery Database

Conditions
-----------------
Liver Surgery

Intervention / Treatment
-----------------
* Other: Data collection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient undergoing liver surgery for benign liver tumor, primary or secondary liver cancer Exclusion Criteria: Patient refusal

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Institut Paoli-Calmettes patients undergoing liver surgery<br> | Other: Data collection<br>* Colelction of pre-operative, surgical and post-surgical data<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Epidemiological description | Epidemiological description of the patients who undergo hepatic surgery at Institut Paoli-Calmettes | 5 years |
Talent Aortic Cuff Stent Graft System Compassionate Use Registry

Study Overview
=================
Brief Summary
-----------------
An evaluation of the TALENT Aortic Cuff in patients with existing AneuRx stent grafts who have experienced sub-optimal stent graft outcomes and are not deemed suitable candidates for treatment with an AneuRx Aortic Cuff.

Detailed Description
-----------------
The primary purpose of this registry is to provide an endovascular means of treatment for those patients experiencing a sub-optimal outcome related to the implanted AneuRx bifurcated stent graft and who are not deemed suitable candidates for treatment with an AneuRx Aortic Cuff. A sub-optimal outcome is defined as either a Type I or Type III endoleak and/or an inadequate seal zone (< 1 cm). For Registry purposes, a Type III endoleak will be defined as a proximal modular endoleak.

Official Title
-----------------
Compassionate Use of the TALENT Aortic Cuff in the Treatment of Patients Previously Treated With the AneuRx Stent Graft System With Sub-Optimal Stent Graft Outcomes

Conditions
-----------------
Abdominal Aortic Aneurysms

Intervention / Treatment
-----------------
* Device: TALENT Aortic Cuff Abdominal Stent Graft


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient >= 18 years of age Patient has a serious disease or condition No generally acceptable alternative for treating patient is available Patient has had the AneuRx stent graft system implanted >= 30 days Patient has suboptimal outcome with the AneuRx stent graft system as evidenced by one or more of the following: Type I endoleak Type III endoleak (Proximal, modular) Loss of seal zone Proximal aortic neck diameter >= 14mm and <= 30mm Angle between axis of the suprarenal aorta and aneurysm neck is <= 60 degrees Patient is able and willing to be available for 12,24,26,48 and 60 months post-procedure Exclusion Criteria: Patient is pregnant of lactating Arterial access cannot be crossed with a delivery system Excessive vessel tortuosity Excessive aortic calcification AneuRx stent graft system implanted within the last 30 days

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: TALENT Aortic Cuff Abdominal Stent Graft|Endovascular Aneurysm Repair|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Abdominal Aneurysm, Endovascular Aortic Repair (EVAR), Endovascular Stent Graft, Endograft
Effect of Paratracheal Pressure on Mask Ventilation

Study Overview
=================
Brief Summary
-----------------
This study aims to evaluate the effect of paratracheal pressure on mask ventilation in anesthetized obese patients in terms of expiratory tidal volume, and peak inspiratory pressure.

Official Title
-----------------
Effect of Paratracheal Pressure on Mask Ventilation in Anesthetized Obese Patients

Conditions
-----------------
Ventilation

Intervention / Treatment
-----------------
* Other: Mask ventilation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult patients with a body mass index ≥ 30 kg.m-2 undergoing general anesthesia for elective surgery Exclusion Criteria: Structural abnormalities or diseases in the face, neck, upper airway, or esophagus Increased risk of aspiration (pregnancy) Carotid artery stenosis, cerebrovascular disease

Ages Eligible for Study
-----------------
Minimum Age: 19 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Paratracheal pressure<br>After the induction of anesthesia, paratracheal pressure is applied during mask ventilation. | Other: Mask ventilation<br>* Mask ventilation is performed under paratracheal pressure or no pressure in a randomized, crossover manner.<br>|
| Active Comparator: No pressure<br>After the induction of anesthesia, no pressure is applied during mask ventilation. | Other: Mask ventilation<br>* Mask ventilation is performed under paratracheal pressure or no pressure in a randomized, crossover manner.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Expiratory tidal volume | Volume controlled mechanical ventilation is delivered during mask ventilation. Expiratory tidal volumes on the monitor screen are recorded during mask ventilation | For 2 min of mask ventilation after the induction of anesthesia | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Peak inspiratory pressure | Peak inspiratory pressure on the screen is recorded during mask ventilation. | For 2 min of mask ventilation after the induction of anesthesia | 
| Inadequate tidal volume | Incidence of tidal volume less than 150 mL is recorded. | For 2 min of mask ventilation after the induction of anesthesia | 
| Incidence of hypoxia | Occurrence of hypoxia (SpO2 <90%) is recorded. | For 2 min of mask ventilation after the induction of anesthesia |
Intraocular Pressure Control After Anterior Segment Laser - Comparison Between 2 Drugs

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to compare the intra-ocular (IOP) control efficacy between brimonidine 0.1% vs. 0.2% after laser peripheral iridotomy (LPI).

Detailed Description
-----------------
Postoperative IOP elevation is one of the most common complications after LPI.Previous studies showed that brimonidine 0.2% is effective in blunting IOP spikes after LPI.This prospective randomized double-masked interventional study will include patients with bilateral narrow angles, defined by irido-trabecular contact in >180o on gonioscopy.Pilocarpine 1% will be used in both eyes, and 30 minutes later, brimonidine 0.1% randomly used in one eye and brimonidine 0.2% in the contra-lateral eye. LPI with Nd:YAG laser is performed 30 minutes later in both eyes by a single glaucoma specialist. IOP measurements are assessed before the use of any eyedrop (basal IOP), 30 minutes after pilocarpine (pre-brimonidine), and 30, 60, 120, 180 minutes after LPI. Pachymetry, ultrasonic biometry, gonioscopy, and total YAG laser energy are recorded. Non-parametric test will be used for analysis.

Official Title
-----------------
Short-term Intraocular Pressure Control After YAG Iridotomy - Comparison Between Brimonidine 0.1% vs. 0.2%

Conditions
-----------------
Glaucoma, Narrow Angle

Intervention / Treatment
-----------------
* Procedure: YAG laser peripheral iridotomy
* Procedure: YAG laser peripheral iridotomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: bilateral narrow angles, defined by irido-trabecular contact in >180o on gonioscopy Exclusion Criteria: previous cataract surgery

Ages Eligible for Study
-----------------
Minimum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: brimonidine 0.2%<br> | Procedure: YAG laser peripheral iridotomy<br>* 1 drop 30 minutes before yag laser iridotomy<br>* Other names: Alphagan;|
| Active Comparator: brimonidine 0.1%<br> | Procedure: YAG laser peripheral iridotomy<br>* 1 drop 30 minutes before yag laser iridotomy<br>* Other names: Alphagan z;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| intra-ocular pressure increase | mean intra-ocular pressure increase after laser peripheral iridotomy | one year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
intra-ocular pressure, iridectomy, gonioscopy, ocular tonometry
Effects of Stereotype Threat on Impulsivity and Its Relation to Alcohol Use in African Americans: An fMRI Study

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to investigate the behavioral and neural correlates of stress exposure. Results from this study will enrich the understanding of how sociocultural, behavioral, and neural factors combine to influence alcohol use.

Official Title
-----------------
Effects of Stereotype Threat on Impulsivity and Its Relation to Alcohol Use in African Americans: An fMRI Study

Conditions
-----------------
Alcohol Drinking

Intervention / Treatment
-----------------
* Behavioral: Task-based behavioral intervention
* Behavioral: Task-based behavioral intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Between 21 and 35 years of age (inclusive); Fluent in English; Right-handed Exclusion Criteria: Younger than 21 years of age; Left-handed

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: no stress exposure<br>no threat stress | Behavioral: Task-based behavioral intervention<br>* Brief behavioral intervention is absent of stressors.<br>|
| Active Comparator: stress exposure<br>exposure to stress threat | Behavioral: Task-based behavioral intervention<br>* Brief behavioral intervention involves interacting with common everyday types of stress.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood oxygen-level dependent (BOLD) signal | Blood oxygen-level dependent (BOLD) signal in brain regions of interest (ROI) measured using fMRI | Baseline | 
| Resting-state functional connectivity in brain regions | Resting-state functional connectivity - brain activity measured using fMRI | Baseline |
Impact of Fluid Resuscitation Protocol on the Incidence of Reoperation for Bleeding After Emergency Cardiopulmonary Bypass Grafting

Study Overview
=================
Brief Summary
-----------------
This is a retrospective data analysis of patients that underwent elective or emergency cardiopulmonary bypass. Resternotomy due to bleeding is frequent after sternotomy. Also due to implementation of Argipressin into clinical practice fluid resuscitation protocol has changed to more vasopressors and less fluid within the past five years. The investigators want to explore the influence of volume resuscitation protocol on incidence of rethoracotomy during the past twenty years.

Official Title
-----------------
Impact of Fluid Resuscitation Protocol on the Incidence of Reoperation for Bleeding After Emergency Cardiopulmonary Bypass Grafting

Conditions
-----------------
Resternotomy

Intervention / Treatment
-----------------
* Other: Assessment of reason for resternotomy
* Other: Assessment of reason for avoidance of resternotomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients that underwent elective or emergency aortocoronary bypass at the University Hospital Basel between 2009 and 2020. Exclusion Criteria: None.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Resternotomy<br> | Other: Assessment of reason for resternotomy<br>* No intervention is performed. Reasons for resternotomy (coagulation, fluid balance and other) are retrospectively assessed.<br>|
| No resternotomy<br> | Other: Assessment of reason for avoidance of resternotomy<br>* No intervention is performed. Reasons for avoidance resternotomy (coagulation, fluid balance and other) are retrospectively assessed.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Resternotomy | Resternotomy yes or no after elective or emergency aortocoronary bypass | 7 days |
Virtual Reality Pain Control During Burn Wound Care

Study Overview
=================
Brief Summary
-----------------
Using Virtual Reality as a form of Distraction during Burn Care.

Detailed Description
-----------------
The purpose of the study is to investigate the effectiveness of virtual reality (a form of distraction) in order to reduce patients' procedural burn pain.

Official Title
-----------------
Use of Virtual Reality for Adjunctive Treatment of Burn Pain

Conditions
-----------------
Burn

Intervention / Treatment
-----------------
* Behavioral: Virtual Reality Distraction


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Able to complete subjective evaluations of pain English-speaking Not demonstrating delirium, psychosis, or any form of Organic Brain Disorder Able to communicate orally Exclusion Criteria: Incapable of indicating subjective evaluation of pain Non-English-speaking Severe head or neck injury or other medical conditions that prohibit patient from wearing VR helmet Demonstrating delirium, psychosis, or Organic Brain Disorder Unable to communicate verbally Significant developmental disability Extreme susceptibility to motion sickness Reports having no problem with pain during wound care.

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Virtual Reality distraction | Behavioral: Virtual Reality Distraction<br>* Using virtual reality distraction during a procedure<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| We use GRS, McGill to measure the outcome. |  | once a day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Virtual Reality Distraction
Staples Versus Dermabond for Closure of the Skin After Cesarean Section

Study Overview
=================
Brief Summary
-----------------
Two of the more frequently used options for skin closure following a cesarean delivery include staples or sutures (stitches). Another method of closure is Dermabond- liquid skin adhesive. This method of closure is used less frequently than either staples or sutures. Few studies have been done regarding whether Dermabond is preferable or affect the outcome of a cesarean section surgery. The aim of our study is to find weather Dermabond haas better result for the closure of cesarean section wounds.

Official Title
-----------------
Staples Versus Dermabond for Closure of the Skin After Cesarean Section

Conditions
-----------------
Cesarean Section Wound

Intervention / Treatment
-----------------
* Procedure: Dermabond- liquid skin adhesive


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Woman over 18 year Woman having elective caesarean section Exclusion Criteria: Age under 18 Woman having an emergency caesarean section

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Woman with previous ceasarean section - staples<br> | Procedure: Dermabond- liquid skin adhesive<br>* Dermabond- liquid skin adhesive<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cosmetic objective evaluation of the scar |  | 6 weeks postoperatively | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The difference in pain between the two type of closure |  | 1 and 4 days postoperatively | 
| The difference in patient satisfaction with the scar result |  | 6 weeks postoperatively |
The Impact of Riboflavin on the Severity and Duration of Sports Related Concussion

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to investigate the effectiveness of riboflavin to decrease the duration of time for a student-athlete to return to participation in sports after a sports related concussion.

Official Title
-----------------
The Impact of Riboflavin on the Severity and Duration of Sports Related Concussion

Conditions
-----------------
Sports Related Concussion

Intervention / Treatment
-----------------
* Drug: Riboflavin 400mg daily


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All UVa and JMU student-athletes over the age of 18 years old who are diagnosed with a sports related concussion Exclusion Criteria: Less than 18 years old Greater than 24 hours have elapsed since the concussion occurred. The student-athlete has already participated in the study during which he/she took Riboflavin Non-sports related concussion not incurred while participating in the sport or training for the sport. As an example, a student-athlete who sustains a concussion as a result of a motor vehicle accident will be excluded from the study for that concussion

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Riboflavin<br> | Drug: Riboflavin 400mg daily<br> <br> * Other names: Vitamin B2;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to return to full participation in sports after a sports related concussion |  | 21 days or less | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Concussion, Sports related concussion, mTBI, Vitamin B, Riboflavin