Cardiovascular and Muscular Adaptations to Recreational Soccer and Strength Training in Elderly Healthy 65-75-year-old Men

Study Overview
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Brief Summary
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A one-year intervention study of 41 healthy elderly men aged 65-75-years.Of these, 24 subjects are untrained men with no regular training activity for the last 5 years. After medical screening and pre-testing, they will be randomized into a football group (n=9), a strength-training group (n=9) or a sedentary control group (n=6). Additional 17 subjects are recruited from local football clubs and have been active football players for the last 40 years. Training will be performed 3x1 hour per week and evaluation will take place after 0, 3 and 12 months. Primary endpoints will be changes in cardiac and vascular structure and function measured by advanced echocardiography (tissue Doppler and speckle tracking imaging), and peripheral arterial tonometry (Endo---PAT device). Secondary endpoints will be evaluation of potential changes in VO2 max, blood pressure, muscle capillaries, lipid profile, circulating catecholamines, body composition, and insulin resistance.

Official Title
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Cardiovascular and Muscular Adaptations to Recreational Soccer and Strength Training in Elderly Healthy 65-75-year-old Men

Conditions
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Adaptation Reaction

Intervention / Treatment
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* Other: physical training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 65-75 year old men healthy non-smoking non-hypertension non- cardiac disease Exclusion Criteria: smoking cardiac disease biomechanical disorders cardiac medication

Ages Eligible for Study
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Minimum Age: 65 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: soccer training intervention<br> | Other: physical training<br>* training<br>|
| Other: strength training intervention<br> | Other: physical training<br>* training<br>|
| No Intervention: control group<br>elderly men with no change in daily activities | |
| No Intervention: active soccer control group<br>veteran soccer players with a 40 year history of continues soccer playing | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cardiac adaptations | changes in cardiac function after 16 weeks and one year measured by advanced echocardiography (tissue Doppler and speckle tracking imaging) | after 16 weeks and one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiorespiratory fitness, muscular adaptations, Bloodpressure and Glucose tolerance | Improvements in cardiorespiratory fitness assessed with VO2 max treadmill testing. Changes in muscular tissue with biopsies from the vastus lateralis muscle. Changes in resting blood pressure in incline postion Changes in glucose tolerance with oral glucose tolerance testing | after 16 weeks and one year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cardiac, vascular, muscular, adaptations, soccer training, strength training