Impact of a Sleep Debt in Middle-Aged and Older Adults

Study Overview
=================
Brief Summary
-----------------
This project has 6 aims. To examine the impact of recurrent partial sleep loss in young, middle-aged and older men and women. Sleep will be restricted to 4 hours. To test the hypothesis that extending bedtimes to allow for sleep recovery will reverse the metabolic, endocrine, and cardiovascular and neuro-behavioral alterations resulting from sleep restriction. Sleep will be extended to 12 hours following the 4 hour sleep restriction. To test the hypothesis that there are age and gender differences in the total amount of sleep recovery obtained during the week of 12-hour bedtimes. To test the hypothesis that there are age and gender differences in sleep capacity (the amount of time an individual can sleep per night when there is no sleep debt). To test the hypothesis that sleep capacity is partly determined by baseline levels of slow-wave sleep and slow-wave activity. To determine whether sleep capacity is related to sleep need by examining metabolic, endocrine, cardiovascular and neuro-behavioral changes with the amount of the individual sleep debt.

Official Title
-----------------
Alteration of Sleep and Circadian Timing in Aging- Impact of a Sleep Debt in Middle-Aged and Older Adults

Conditions
-----------------
Sleep Restriction

Intervention / Treatment
-----------------
* Other: Sleep restriction


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: normal weight healthy age 18-75 old Exclusion Criteria: sleep disorder irregular life habits (shift workers, travelers) smokers on medication consumption of > 2 alcohol or caffeinated beverages/day

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Normal (8 hours) sleep time<br>Subjects are studied under normal sleep time conditions. | |
| Experimental: Sleep restriction<br>Sleep restriction to 4 hours of sleep per night. Overnight sleep recording, measures of endocrine and metabolic (from blood), cardiovascular (measures of blood pressure and heart rate), performance ( before and after sleep restriction and after sleep recovery. | Other: Sleep restriction<br>* Sleep restriction.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Endocrine, metabolic, cardiovascular changes performance and autonomic nervous system activity before and after sleep restriction and after sleep recovery. |  | Completion of 23 day study | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Sleep, young adults, middle-age adults, older adults