Herpes Zoster: Risk Factors, Complications and Special Situations

Study Overview
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Brief Summary
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This retrospective analysis is to investigate patients' history and clinical presentation in Herpes Zoster (HZ), Zoster-related complications, post-Zoster neuralgia and Herpes Zoster management in order to improve the management of HZ patients, to refine HZ-vaccination strategies and elucidate cost factors of HZ in in the setting of a university hospital in Switzerland generally and in a dermatology department specifically.

Official Title
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Herpes Zoster: Risk Factors, Complications and Special Situations- a Retrospective Analysis

Conditions
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Herpes Zoster

Intervention / Treatment
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* Other: retrospective chart review


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Reports of patients with HZ at University Hospital Basel between 2004-2018 Exclusion Criteria: rejection to use patient data

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: retrospective chart review|retrospective report review of HZ patients treated between 2005 and 2018 in the Department of Dermatology at the University Hospital Basel|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of patients' history | Free text evaluation of patients' history (age, sex, comorbidities, immunosuppression, obesity, human immune deficiency Virus (HIV), profession, current medication, vaccinations, seasonal occurence of HZ, history of Varicella Zoster virus (VZV) infection | single time point assessment at baseline | 
| Description of the clinical presentation of HZ | Free text description of the clinical presentation of HZ (localisation, dermatomes affected), Zoster-related acute pain | single time point assessment at baseline | 
| Evaluation of zoster-related complications | Free text evaluation of zoster-related complications (ophthalmic zoster, generalised HZ, Ramsay-Hunt syndrome, zoster meningoencephalitis) | single time point assessment at baseline | 
| Evaluation of the herpes zoster management | Free text evaluation of the herpes zoster management (local (antiviral) treatment, systemic antiviral and other treatments, number of revisits, average treatment-related costs, hospitalisations (rate, duration) | single time point assessment at baseline | 
| Assessment of post-zoster neuralgia | Free text assessment of post-zoster neuralgia (annual incidence, treatment options used) | single time point assessment at baseline | 
| Evaluation of zoster and pregnancy | Free text evaluation of zoster and pregnancy (incidence, time of pregnancy, pregnancy outcomes and complications) | single time point assessment at baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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post-zoster neuralgia, Herpes Zoster-related complications