Correlation Between Epistaxis and Cardiovascular Disease

Study Overview
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Brief Summary
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Investigators examine blood-pressure variance, several cardiovascular risk factors of patient with epistaxis. As a result of collected data, investigators look into correlation between epistaxis and hypertensive cardiovascular disorder.

Detailed Description
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This study is prospective observational single blinded study. A participant is visit in the ER who patient with epistaxis. Investigators will enroll 50 patients with epistaxis. Exclusion criteria is that patient needs immediately treatment for hypertensive urgency or patient with nasal trauma. Investigators examine blood-pressure (BP) at five times in Emergency Department (ED) and out-patient department (opd) of Otorhinolaryngology (OL) . Investigators explain this study and ask to write consent for participant. After proper management of epistaxis, investigators get blood sampling of the participant and, the participant has a reservation to opd of cardiovascular division of Internal Medicine (CV opd) in the hospital. When the participant visit CV opd, the participant undergo 24-hours-BP-monitoring and Pulse wave velocity (PWV). After that, the participant will be follow-up for 3 months. Investigators collect 50 data from 50 participants as a registry and analyze the data.

Official Title
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Epistaxis Correlate With Cardiovascular Disease?

Conditions
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Cardiovascular Disease, Epistaxis

Intervention / Treatment
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* Biological: Blood-pressure variability


Participation Criteria
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Eligibility Criteria
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Group A Inclusion Criteria: age is over 18 with spontaneous epistaxis Exclusion Criteria: they needs immediately treatment for hypertensive urgency. they don't want to participate in this investigation. Group B Inclusion Criteria: age is over 18 with bleeding of wound Exclusion Criteria: their wounds' condition is serious or their pain is much severe. they don't want to participate in this investigation.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Spontaneous epistaxis<br>A participant enroll if their age is over 18 with spontaneous epistaxis and their cause of visiting ER is spontaneous epistaxis. Exclusion criteria is that they needs immediately treatment for hypertensive urgency. And, they don't want to participate in this investigation. Investigators examine their blood-pressure variability and cardiovascular risk throughout their blood sample analysis. | Biological: Blood-pressure variability<br>* Day to Night Blood pressure variability<br>|
| Bleeding of wound<br>A participant enroll if their age is over 18 with bleeding of wound and their cause of visiting ER is to bleed on wound. Exclusion criteria is that their wounds' condition is serious or their pain is much severe. And, they don't want to participate in this investigation. Investigators examine their blood-pressure variability and cardiovascular risk throughout their blood sample analysis. | Biological: Blood-pressure variability<br>* Day to Night Blood pressure variability<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cholesterol level in each group |  | 1 day | 
| BP variability level in each group |  | 1 day | 
| Pulse wave velocity in each group |  | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Smoking History in each group | Example = 12 pack-year | 1 day | 
| Body Mass Index in each group |  | 1 day |