linjc16/ctgov huggingface dataset:
Changing Patterns of Candida Infections in Urban Medical Centers

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine the changing patterns of infection caused by Candida species in urban medical centers and its influence on patient outcomes. A retrospective cohort study design will be employed with the main outcome measure being hospital mortality. Secondary outcomes including microbiologic clearance of the infection, duration of hospitalization, and the intensive care unit (ICU) length of stay will also be assessed.

Detailed Description
-----------------
The following information that was collected as part of the patient's clinical treatment will be collected: age, sex, occupation, hospital location at the time of positive culture (ER, medical ward, ICU, etc.), prior hospitalization, receipt of outpatient dialysis, home care or other regular medical care (eg, outpatient chemotherapy), presence of invasive devices, receipt of antibiotics, including their type and whether they were adequate for the resistance profile of the organism, prior positive microbiologic cultures, time and location of positive cultures, underlying diseases and severity of illness, presence of urinary or intravascular devices, recent immunomodulative therapies or radiation therapy, physical exam findings, laboratory and radiographical data, antimicrobial usage within 30 days of onset of the infection, microbiological data and resistance patterns, choice of antibiotics once organism identified, bacteriological outcomes, laboratory results, demographic information, medications, clinical outcome, gender, height, weight, ethnicity, and past medical history. We will collect information retrospectively.

Official Title
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Changing Patterns of Candida Infections in Urban Medical Centers: Emphasis on the Emergence of Non-albicans Species and Their Influence on Clinical Outcomes

Conditions
-----------------
Infection, Candida, Non Albicans Species

Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: All hospitalized patients with a positive blood culture for Candida will be eligible. Exclusion Criteria: None
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| dead or alive | Health status | end of study | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
infection, candida
Non-interventional Study of Ziprasidone in the Treatment of Bipolar and Schizoaffective Disorders.

Study Overview
=================
Brief Summary
-----------------
Assessment of ziprasidone safety and efficacy in the treatment of bipolar and schizoaffective disorders.

Detailed Description
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Method: Consecutive patient sampling. Patients were included in the study in consecutive manner if they fulfilled the inclusion criteria and any of the exclusion criteria were not present.

Official Title
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Treatment Of Manic Or Mixed Episodes Of Up To Moderate Severity In Patients With Bipolar Disorder And Schizoaffective Disorder

Conditions
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Affective Psychosis, Bipolar, Mania, Manic-Depressive Psychosis

Intervention / Treatment
-----------------
* Drug: ziprasidone


Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: Manic and mixed episodes of up to moderate severity in patients with Type I and II bipolar disorder and schizoaffective disorder; either first diagnosed or repeated episodes Exclusion Criteria: Hypersensitivity to ziprasidone prolonged QTc interval coadministration with substances that are prolonging the QTc interval recent acute MI, cardiac failure, patients with arrhythmias treated with class IA or III medicaments

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1 cohort of patients treated with ziprasidone<br> | Drug: ziprasidone<br>* Ziprasidone 40 mg twice daily taken with food. Daily dosage may subsequently be adjusted on the basis of individual clinical status up to a maximum of 80 mg twice daily. If indicated, the maximum recommended dose may be reached as early as day 3 of treatment.<br>* Other names: Geodon, Zeldox;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical global impression |  | 3 months | 
| Recording of extrapyramidal symptoms |  | 3 months | 
| Changes in manic symptoms over course of treatment |  | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Severity of disease |  | 3 months | 
| Adverse Events |  | 3 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Safety of ziprasidone, efficacy of ziprasidone, manic episodes in bipolar disorder, mixed episodes in bipolar disorder, schizoaffective disorder.
Obesity Childhood in Cuenca-Ecuador: Prevalence and Risk Factors

Study Overview
=================
Brief Summary
-----------------
Hypothesis: Obesity in children of Cuenca is related with socioeconomical status and physical activity habits. Summary: The prevalence of obesity and overweigh in all age groups are increasing rapidly in the world. Some factors like physical activity, socioeconomical status, dietary habits, gender, besides genetic factors influence in the development of obesity. In Cuenca - Ecuador lack information related to prevalence of overweight and obesity in children and the risk factors related. Socioeconomical status and quality of physical activity are assessed using specially designed questionnaires in a randomized sample of children 6 to 9 years of age of Cuenca city. Nutritional status is assessed using body mass index, relation weight/age and height/age. These data are helpful to develop programs focused to improve nutritional status in scholars of Cuenca.

Official Title
-----------------
Baseline Study. Obesity Childhood in Cuenca-Ecuador: Prevalence and Risk Factors

Conditions
-----------------
Obesity

Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: All children of selected sample with an approved consent by their parents Exclusion Criteria: Children with malformations that not permit take anthropometric measures.

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 9 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Nutritional status of scholars, Risk factors of obesity, Socioeconomical status, Physical activity habits
Stress Reactivity and Nicotine Addiction Among African American and White Smokers

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to examine racial differences in smoking behaviors and stress responses between African American and white male smokers.

Detailed Description
-----------------
Cigarette smoking is a leading cause of morbidity and mortality from lung cancer among adults in the US. Stress relief and smoking cessation is the best preventive strategy for reducing lung cancer risk and addressing racial disparities in outcomes. Despite this, racial differences are found among those that make quit attempts. Stress has been found to be related to smoking initiation, maintenance, and relapse. Yet, differences in stress responses have not been examined between African American and white smokers. Therefore, this study will examine racial differences in stress responses and smoking behaviors between African American and white male smokers

Official Title
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Biological Pathways in Stress Reactivity and Nicotine Addiction Among African American and White Smokers

Conditions
-----------------
Smoking, Smoking Behaviors, Smoking Cessation, Stress Reaction

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: African American and white males Between the ages of 18-75 years old Smoke at least 5 to 10 cigarettes per day Exclusion Criteria: Smokers who have a serious cognitive disorder Have a personal history of lung cancer Personal history of usage of illicit drug and alcohol abuse Enrollment in a smoking cessation treatment program during the past 6 months Current use of a nicotine replacement therapy Have any positive responses on the Mini International Neuropsychiatric Interview (MINI) screener

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Examining racial differences in acute stress responses | Examine racial differences in acute stress responses using a validated psychological stress challenge called the Trier Social Stress Test (TSST) | Within 1 month following baseline | 
| Examining changes in daily cortisol patterns according to race | Examine racial differences in daily diurnal cortisol slopes to evaluate hypothalamic-pituitary-adrenal-axis dysregulation and acute stress | Baseline, 4- and 8 weeks post Trier Social Stress Test laboratory visit | 
| Examine changes in stress responses and smoking behaviors as it relates to social determinant factors | Patients will be administered a survey using validated measures to examine socioeconomic, structural, and psychosocial stressors that impact daily stress and smoking behaviors | Baseline, 4- and 8-weeks post Trier Social Stress Test laboratory visit |
Safety and Preliminary Efficacy Study of V404 PDS in Uveitis

Study Overview
=================
Brief Summary
-----------------
This study is intended to evaluate the safety of V404 PDS in patients with chronic non-infectious uveitis. Secondarily, the study will evaluate whether V404 PDS can provide clinically measurable benefit over an extended period of time in patients with chronic non-infectious uveitis.

Official Title
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A Prospective, Multi-Center, Randomized, Controlled Clinical Trial Designed to Evaluate the Safety and Preliminary Efficacy of V404 PDS in Chronic Noninfectious Uveitis

Conditions
-----------------
Uveitis, Posterior, Uveitis, Intermediate

Intervention / Treatment
-----------------
* Drug: V404


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years of age or older Confirmed diagnosis of active uveitis Sufficient lens/media clarity Meet best-corrected visual acuity criteria Willing and able to use contraception Exclusion Criteria: Pregnant, breast feeding Uncontrolled glaucoma Intraocular surgery or periocular/intraocular injections within 6 weeks Periocular or intraocular steroid within 3 months Prior vitrectomy Prior corneal transplant Prior fluocinolone implant Allergy or sensitivity to study drug Participation in other trial within 30 days Abnormal liver function History of positive serum tuberculosis test

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Low Dose V404 PDS<br>Sustained intravitreal delivery of methotrexate (0.6 mg) | Drug: V404<br>* Sustained Release<br>* Other names: Methotrexate;|
| Experimental: High Dose V404 PDS<br>Sustained intravitreal delivery of methotrexate (2.3 mg) | Drug: V404<br>* Sustained Release<br>* Other names: Methotrexate;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Frequency of adverse events |  | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in vitreous haze score |  | Baseline, 6 Months |
Prognostication of Recovery in Early Disorders of Consciousness After COVID-19

Study Overview
=================
Brief Summary
-----------------
The primary aim of this research proposal is to use multimodal metrics (e.g., clinical data and advanced neuroimaging) in the early (i.e., acute hospitalization) phase of recovery from COVID-19-related disorders of consciousness to predict outcome at 3, 6, and 12 months post-hospitalization. We aim to construct an algorithm that synthesizes the results of these metrics to help predict recovery.

Official Title
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Prognostication of Recovery in Early Disorders of Consciousness After COVID-19

Conditions
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Covid19, Coma, Consciousness Disorder

Intervention / Treatment
-----------------
* Diagnostic Test: Functional MRI


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age 18 or older, positive diagnosis of COVID-19, diagnosis of coma, vegetative state or minimally conscious state per Glasgow Coma Scale (GCS) at time of enrollment (excluding confounders such as sedation) and clinical team plan for an MRI for clinical management. Exclusion Criteria: A subject with any of the following MRI contraindications will not be eligible for this study: electrical implants such as cardiac pacemakers or perfusion pumps ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants ferromagnetic objects such as jewelry or metal clips in clothing that cannnot be easily removed for scanning pregnant volunteers

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COVID-19 Disorders of Consciousness<br>Patients with COVID-19 and disorders of consciousness | Diagnostic Test: Functional MRI<br>* measurement of functional brain networks<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disability Rating Scale score | Functional outcome measure. Maximum score of 29 represents high disability, minimum score of 0 represents no disability. Higher scores represent higher level of disability. | 6 months |
Recurrent Collection By Medical Student in General Medicine

Study Overview
=================
Brief Summary
-----------------
The project for the recurrent collection of data from interns in general medicine is a formalized description of the consultations attended by medical students during their outpatient training. This formalization uses the International Classification of Primary Care. This project aims to create a research network between general medical interns, mainly for their thesis, which pools their observations in a database accessible to all participants.

Official Title
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Recurrent Collection By Medical Student From Sorbonne-Université in General Medicine

Conditions
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General Practice

Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: consultation of his general practitioner Exclusion Criteria: None
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| reason for consultation | ICPC | through study completion, an average of 6 month | 
| diagnosis | ICPC | through study completion, an average of 6 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
ICPC, citizen science, Medical student
Pediatric ANCA Associated-vasculitis

Study Overview
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Brief Summary
-----------------
The incidence in pediatrics is very low (about 0.5 per million according to a French study) and therefore the data on the pathology very poor, especially on the therapeutic level. Without appropriate treatment, the mortality rate of the pathology is very high. Existing treatments are almost exclusively composed of immunomodulatory and/or immunosuppressive treatments. Complications related to pathology and iatrogeny are among the first causes of mortality from this pathology and deserve to be studied in order to be known and if possible avoided. The purpose of the study is to achieve a national comparison of clinical and therapeutic practices.

Official Title
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Pediatric ANCA Associated-vasculitis : Latest Clinical Review and Therapeutic Outcomes. A Retrospective Epidemiological Study on a French Cohort

Conditions
-----------------
ANCA-Associated Vasculitis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Minor subject (<18 years old) Diagnosis of ANCA vasculitis according to the international criteria for defining the pathology, GPA or MPA form between 2011 and 2020. Subject (and/or his parental authority) who has not expressed, after being informed, his opposition to the reuse of his data for the purposes of this research. Exclusion criteria: Subject (or his parents) having expressed his (their) opposition to participating in the study Patients with vasculitis has ANCA in the form of EGPA Associated pathologies that cannot be related to the diagnosis of ANCA vasculitis and whose prognosis can lead to biases in the efficacy and/or complications related to treatments.

Ages Eligible for Study
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Minimum Age: 1 Year
Maximum Age: 17 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Retrospective study of clinical and therapeutic practices at the national level. |  | Files analysed retrospectively from January 01, 2011 to December 31, 2020 will be examined] | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
ANCA-Associated Vasculitis, Pediatric ANCA, Vasculitis
KT(KT Corporation)-SNUBH(Seoul National University Bundang Hospital) U-health Cooperative Research

Study Overview
=================
Brief Summary
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The purpose of this study is to analyse utility and compatibility of U-health solution service based on mobile for chronic wound management.

Detailed Description
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In this study, 'the management of pressure ulcer' defined as procedures comprising wound assessment, wound dressing and infection control, visually evaluated the outcomes of 'the management of pressure ulcer' through the tele-consultation. This study designed to draw service targets based on utility and compatibility of U-health solution service and to analyse whether health providers use U-health solution service.

Official Title
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KT-SNUBH U-health Cooperative Research: Target Selection and Consumers' Intention Research for Commercialization of the Pressure Ulcer Management u-Health Solution

Conditions
-----------------
Pressure Ulcer

Intervention / Treatment
-----------------
* Device: Smart phone


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subject who has pressure ulcer or Health care provider for wound management Exclusion Criteria: Subject who have Osteomyelitis Subject who have suppuration Subject who participated in other clinical trial within 30 days from screening date

Ages Eligible for Study
-----------------
Minimum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Tele-consultation system<br>compare the Live assessed wound size with the transmitted Smart phone-based wound size through Tele-consultation system | Device: Smart phone<br>* measure the Live assessed wound size and the transmitted Smart phone-based wound size determine dressing materials using Smart phone-based tele-consultation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| concordance rate of wound size between live assessed wound size and transmitted wound size |  | a week from post treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| concordance rate of wound size between live assessed wound size and transmitted wound size |  | 2 weeks from post treatment | 
| concordance rate of wound size between live assessed wound size and transmitted wound size |  | 3 weeks from post treatment | 
| concordance rate of wound size between live assessed wound size and transmitted wound size |  | 4 weeks from post treatment | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
u-health, chronic wound management, pressure ulcer