Assessment of Nutritional Status After Gastric Bypass Surgery

Study Overview
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Brief Summary
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This study is aimed at assessing how Roux-en-Y gastric bypass (RYGP) impacts on energy and nutrients' intake, energy expenditure, and nutritional status in obese patients. It will try quantitate energy and protein balance after RYGP, and to identify how RYGP effects the intake of various common dietary protein sources 16 female patients with BMI > 40 kg/m2 and on a waiting list for bariatric surgery will be included. The following measurements will be performed before, and 1, 3, 6, 12, and 36 months after RYGP body weight body composition (bio impedancemetry) basal metabolic rate (open circuit indirect calorimetry) 24-hour urinary urea excretion fasting blood chemistry energy and macronutrient's intake (3-day dietary recall)

Official Title
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Assessment of Nutritional Status and Vitamin Deficiencies in Obese Subjects After Gastric Bypass Surgery

Conditions
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Obesity, Nutritional Deficiencies

Intervention / Treatment
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* Procedure: Roux-en-Y gastric bypass (RYGP)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age 18-65 years gender: females body mass index >35 kg/m2 Exclusion Criteria: GI tract diseases endocrine diseases

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| obese female subjects<br>16 obese female subjects with BMI > 40 kg/m2 on a waiting list for bariatric surgery | Procedure: Roux-en-Y gastric bypass (RYGP)<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes in daily dietary protein intake | changes in 24-hour protein intake will be evaluated by 7-day food diary; portion size will be assessed with the use of photographs from the SU.VI.MAX study | measurements obtained baseline , and 1,3, 6, 12, 36 months after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes in total energy intake | changes in 24-hour energy intake will be evaluated by 7-day food diary; portion size will be assessed with the use of photographs from the SU.VI.MAX study | measurements obtained baseline , and 1,3, 6, 12, 36 months after surgery | 
| changes in basal metabolic rate | BMR will be measured by indirect calorimetry over a 45-90 min period | measurements obtained baseline , and 3, 6, 12, 36 months after surgery | 
| changes in total energy intake | Changes in daily total energy intake will be evaluated by 7-day food diary; portion size will be assessed with the use of photographs from the SU.VI.MAX study | measurements obtained baseline , and 1,3, 6, 12, 36 months after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Obesity, Gastric bypass, Energy balance, Nutritional status, Protein balance