Endothelial Function Study Before Cardiovascular Surgery

Study Overview
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Brief Summary
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The aim of this clinical trial is to evaluate the effect of chronic obstructive pulmonary disease (COPD) and/or obstructive sleep apnea syndrome (OSAS) on the endothelial function, before cardiovascular surgery, compared to non COPD non OSAS patients undergoing also a cardiovascular surgery, by an observational physiological study. An interim analysis will be performed when 100 patients will be included.

Detailed Description
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Secondary objectives of this clinical trial : To evaluate the effect of COPD and/or OSAS on the systemic inflammation, insulin-resistance and oxydative stress, in comparison with non COPD non OSAS patients. To evaluate the effect of COPD and/or OSAS on the inflammation and oxydative stress of the adipose tissue, in comparison with non COPD non OSAS patients. To validate the STOP-BANG questionnaire in patients undergoing a cardiovascular surgery

Official Title
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Endothelial Function Study Before Cardiovascular Surgery in COPD and/or SAS Patients

Conditions
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Chronic Obstructive Pulmonary Disease (COPD), Obstructive Sleep Apnea Syndrome (OSAS)

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men or women between 18 and 80 years old Patient with planned coronary artery bypass graft surgery Patient with planned peripheral vascular surgery Patient with aortic surgery Exclusion Criteria: Patient with aortic or mitral valvular replacement Patient with emergency peripheral valvular surgery Patient with emergency coronary artery bypass graft surgery Patient with evolutive malignancy disease Pregnant or lactating women Patient with inadvisable bronchodilator (used for functional respiratory) exploration

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COPD+ OSAS- patients<br>Patients with chronic obstructive pulmonary disease (COPD) and without obstructive sleep apnea syndrome (OSAS), before planned cardiovascular surgery | |
| COPD- OSAS+ patients<br>Patients with obstructive sleep apnea syndrome (OSAS) and without chronic obstructive pulmonary disease (COPD), before planned cardiovascular surgery | |
| COPD+ OSAS+ patients<br>Patients with chronic obstructive pulmonary disease (COPD) and with obstructive sleep apnea syndrome (OSAS), with planned cardiovascular surgery | |
| COPD- OSAS- patients<br>Patients without chronic obstructive pulmonary disease (COPD) and without obstructive sleep apnea syndrome (OSAS), before planned cardiovascular surgery | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The primary endpoint is the percent of peripheral arterial tone (PAT) in COPD and/or OSAS patients compared to non COPD non OSAS patients. |  | one week before their cardiovascular surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of the systemic inflammation, insulin-resistance and oxidative stress occurring during COPD and/or OSAS patients compared to non COPD non OSAS patients. |  | one week before their cardiovascular surgery | 
| Evaluation of adipose tissue inflammation and oxidative stress occurring during COPD and/or OSAS patients compared to non COPD non OSAS patients. |  | one week before their cardiovascular surgery | 
| Polysomnography |  | one week before their cardiovascular surgery | 
| Functional respiratory exploration |  | one week before their cardiovascular surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COPD patients, OSAS patients, cardiovascular surgery, Endothelial function