Magnetic Resonance Imaging (MRI) and Decline of Aging Aviator Performance

Study Overview
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Brief Summary
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The primary purpose of this study is to apply state-of-the-art Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopic Imaging (MRSI) techniques to measure changes over time in the brain.

Detailed Description
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We expect that MRI and MRSI techniques will be a useful adjunct in research efforts to understand individual differences in performance of a complex attention-demanding task, such as flying a plane or driving a car. Other predictors of change in performance of a complex task may include simple tests of processing speed and working memory, past training and recent practice of the task, and genetic risk factors for degenerative brain disease. In this project, we will examine whether baseline MR measures are as useful as longitudinal MR measures in predicting amount of change over time in task performance. This research is part of a long-term effort to achieve earlier identification of individuals at risk of decline and ultimately minimize loss of function.

Official Title
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MRI and Decline of Aging Aviator Performance

Conditions
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Age-related Cognitive Decline

Intervention / Treatment
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* Device: MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects will be included if they have participated in the protocol Age-Related Longitudinal Changes in Aviator Performance and agree to participate in this protocol. Exclusion Criteria: Subjects will be excluded if they currently have a major neurological disease, unstable/untreated medical disease (such as untreated hypertension). In consideration of the magnetic fields in which subjects will be placed for the MR scanning, we will also exclude subjects who are unable to safely and comfortably complete the scanning session. This includes individuals who are wearing any metal prosthesis or who have cardiac pacemakers or any other nonremovable metal objects. Subjects reporting a history of severe claustrophobia or poorly controlled back pain will be excluded because it is unlikely they could comfortably remain still in the MRI scanner for the duration of the scan. In addition, subjects who do not fit in the apparatus will also be excluded.

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: MRI|MRI - routine imaging sequences, designed for anatomical quantification|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| flight simulator performance summary score | z-score composite of executing ATC communications, avoiding traffic, monitoring engine malfunctions, visual approach and landing | yearly for up to 6 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CogScreen-AE | computerized battery (assesses processing speed, executive function, paired assoc memory, n-back task, psychomotor tracking | yearly | 
| Salthouse processing speed measures | digit copy & pattern comparison | yearl | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cognitive Aging, Apolipoproteins E, Magnetic Resonance Imaging