Prevalence of Salivary Hypofunction in Patients With Globus Pharyngeus

Study Overview
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Brief Summary
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It is well known that 'globus sensation in throat' is caused by the chronic irritation and inflammation of oral, pharyngeal, or laryngeal mucosa, such as laryngopharyngeal reflux and chronic postnasal drip. Xerostomia and pharyngoxerosis due to salivary hypofunction also proved to induce the mucosal change of the oral cavity and pharynx. However, no previous studies have documented the prevalence of salivary hypofunction in patients with globus pharyngeus. Through this clinical investigation, we hypothesized that the salivary hypofunction might be one of the leading cause of globus pharyngeus.

Detailed Description
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Subjects: patients with symptoms of globus pharyngeus Globus symptom scoring: 0(mild) to 5(severe) Subjective symptom analysis by Standard Table for Xerostomia and Pharyngoxerosis Subjective physical finding analysis by Standard Table for Xerostomia and Pharyngoxerosis Objective analysis of Salivary function by 99m-Tc Salivary scintigraphy --> Define the prevalence of salivary hypofunction in patients with globus pharyngeus (Primary end point) Subsequent analysis (Secondary end point) Group 1: Globus patients with objective salivary hypofunction Group 2: Globus patients with normal salivary function Intervention: Active management for xerostomia (Moisturizing, Gargling, Humidification, Massage of salivary gland, Stimulant of salivary secretion, Artificial saliva) Evaluation of the change of globus symptoms after active management of xerostomia between the Group 1 and Group 2 (at 1 months, at 3 months after the initiation of intervention)

Official Title
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Prevalence of Salivary Hypofunction in Patients With Globus Pharyngeus

Conditions
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Globus Pharyngeus

Intervention / Treatment
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* Behavioral: Conservative management for xerostomia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects with globus pharyngeus symptoms Exclusion Criteria: Subjects with tumors in oral cavity, oropharynx, nasopharynx, hypopharynx, which may cause globus symptoms subjects, who do not undergo the endoscopic exam for the upper aerodigestive tract including oral cavity, oropharynx, nasopharynx, hypopharynx. subjects, who take medications that may have potential effect on the mucosa of the upper aerodigestive tract including oral cavity, oropharynx, nasopharynx, hypopharynx. subjects with poor medical performance (<70%)

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Objective salivary function<br>Based on the salivary scintigraphy, Objective salivary normo-function Objective salivary dysfunction | Behavioral: Conservative management for xerostomia<br>* Active hydration (drinking more than 10 cups of water per day), Humidification, Oral gargle with a diluted (0.05% to 0.1%) chlorhexidine solution, Sugarless chewing gum, Saliva-stimulating sour juice (sugarless orange juice), Commercial artificial saliva, Nasal saline spray 3 to 4 times a day, Warm massage of the 4 major salivary glands.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Globus Pharyngeus, Xerostomia, Salivary Hypofunction, Pharyngoxerosis