Lymphovascular Abnormalities Under Tattoos

Study Overview
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Brief Summary
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The number of tattooed people is increasing and some complications secondary to tattoos suggest that the lymphatic vascular system might be implicated in their pathogenesis. Abnormalities have been described at the level of the lymph nodes draining the tattooed areas but nothing was reported about the lymphatic vessels under tattoos. This is the aim of the present work.

Detailed Description
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19 subjects with 20 tattooed skin surfaces were enrolled after written informed consent and the lymphvascular drainage under the tattooed surface was studied using one near infrared camera device after one intradermal injection of Indocyanine Green.

Official Title
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Lymphovascular Abnormalities Under Tattoos : Preliminary Reports of One Observational Study

Conditions
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Tattoo

Intervention / Treatment
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* Diagnostic Test: near infra red fluorescence lymphatic imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: presence of one tattoo at the level of one limb written informed consent Exclusion Criteria: History of iodine allergy or anaphylactic reactions to insect bites or medication; Hyperthyroidism; Severe cardiac or pulmonary disease; Significant renal failure (creatinine > 400 μmol/l); Pregnancy; any known disease of the skin (such as psoriasis); any disease known to affect the cutaneous tissues (such as diabetes); any previous operation and/or trauma at the level of tattooed limb; familial history of lower limb edemas: skin infection after the tattoo

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: near infra red fluorescence lymphatic imaging|ICG (0.2 ml from 25mg of ICG diluted by 5.0 ml of aqua ad injectabilia) was injected intradermally at the basis of the tattooed cutaneous area and at one point chosen so that the tracer had to flow under this area directly towards the root of the limb|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| normal or abnormal lympho-vascular drainage | The following pictures were considered as normal - lymphatic vessels are well seen and drainage is fast spontaneously | imagings were performed directly after the injection (duration 3 minutes) | 
| normal or abnormal lympho-vascular drainage | The following pictures were considered as normal - lymphatic vessels are well seen after stretching and massages of the injected site | imagings were performed directly after the stretching and massages (duration 3 minutes) | 
| normal or abnormal lympho-vascular drainage | The following pictures were considered as normal - lymphatic vessels are well seen after 30 minutes of normal activities and direct between the injected site and-towards the first lymph node at the root of the limb | imagings were performed after a period of normal activities (duration 30 minutes) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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lymphatic vessels, indocyanin green, near infra red fluorescence lymphatic imaging, tattoo