Mobile Terminal Based Management of Stroke Secondary Prevention Adminstration Effect Research

Study Overview
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Brief Summary
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The investigators want to verify whether mobile application based on stroke strengthen prevention management is more effective than traditional management model or open stroke management platform. Whole blood-impedance based platelet aggregation(WBA) method and VerifyNow detected by aspirin or clopidogrel responsiveness will provide individualized anti-platelet drug selection. Endpoint event is defined as stroke death or relapse. Primary measure outcomes are change of the stroke recurrence rate and mortality after secondary prevention.

Detailed Description
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With high incidence, mortality, morbidity and recurrence rate，stroke has significant impact on national development strategies planning. Improving secondary prevention will strongly promote stroke management in the rapid developing phase of Chinese economy and expansion of health situation. At present lack of high-quality medical resources, low medical permeability cannot remedy extensive prevention failure of stroke. Mobile healthcare is easier to conduct and still in the early stage of explosive growth. This research group has established an open management platform of stroke prevention. And collaborate with Peking University Institute of Information Technology to develop a smart phone application which can be personalized medication reminder, record medication compliance, home blood pressure and blood glucose test results, also can provide doctor-patient communication platform and symptoms alarm. The investigators want to verify whether mobile application based on stroke strengthen prevention management is more effective than traditional management model or open stroke management platform. Whole blood-impedance based platelet aggregation(WBA) method and VerifyNow detected by aspirin or clopidogrel responsiveness will provide individualized anti-platelet drug selection. Control group will be selected from the National Stroke data registration database platform and open platform for stroke prevention. Follow-up period is 2 years. Endpoint event is defined as stroke death or relapse. Primary measure outcomes are change of the stroke recurrence rate and mortality after secondary prevention.

Official Title
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Mobile Terminal Based Management and Platelet Reactivity Modified Drug Regulation of Stroke Secondary Prevention

Conditions
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Stroke

Intervention / Treatment
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* Procedure: Mobile terminal
* Procedure: traditional management
* Procedure: website platform management


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: stroke Exclusion Criteria: refusion in research
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Mobile terminal<br>Stroke received mobile terminal management for secondary prevention administration, as the same time platelet reactivity modified drug selection was performed. Mobile application management conducts the control and regulation for anti hypertension, statin and antiplatelet therapy to increasing drug compliance. | Procedure: Mobile terminal<br>* multiple strategy including mobile terminal based compliance managment, platelet reactivity modified drug adjustment<br>* Other names: Mobile Application;|
| Active Comparator: traditional management<br>Stroke received traditional management for secondary prevention administration | Procedure: traditional management<br>* aspirin or clopidogrel monotherapy or double treatment for<br>* Other names: traditional second prevention;|
| Active Comparator: website platform management<br>Stroke received website platform management for secondary prevention administration. Website platform management conducts the control and regulation for anti hypertension, statin and antiplatelet therapy to increasing drug compliance. | Procedure: website platform management<br>* second prevention based on website platform management<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change of the stroke recurrence rate | After secondary prevention | 2 years stroke recurrence rate | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change of the stroke mortality | After secondary prevention | 2 years stroke mortality | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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stroke, secondary prevention, platelet response polymorphism, mobile terminal