VX-770 for the Treatment of Chronic Bronchitis

Study Overview
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Brief Summary
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This research study will test how well a new drug affects bronchiectasis or chronic bronchitis. The new drug, Ivacaftor (KALYDECO), is a drug that has recently been approved by the U.S. Food and Drug Administration (FDA) for patients with a lung disease called Cystic Fibrosis (CF). It has not been approved for use in patients with bronchiectasis or chronic bronchitis.

Detailed Description
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The study is an open label study of orally-administered ivacaftor in subjects with chronic bronchitis and/or bronchiectasis. Subjects will be administered the study drug ivacaftor 150 mg twice daily (BID). The study drug is commercially available and will be purchased by the participant.

Official Title
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An Open Label Study to Investigate the Role of Ivacaftor (VX-770) for the Treatment of Chronic Bronchitis With CFTR Dysfunction

Conditions
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Chronic Bronchitis

Intervention / Treatment
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* Drug: Ivacaftor (VX-770)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male or Female age 18 years A Clinical diagnosis of Bronchiectasis and/or Chronic Bronchitis in the investigators opinion Exhibit symptoms of chronic bronchitis as defined by the Medical Research Council FEV1 percent predicted greater than 40 percent Post Bronchodilator Clinically stable in the last 4 weeks with no evidence of exacerbation Weight of 40 kg to120 kg Willingness to use at least one form of acceptable birth control including abstinence, condom with spermicide, or hormonal contraceptives Willing to monitor blood glucose if known history of diabetes mellitus requiring insulin or medical therapy Element of CFTR Dysfunction, as defined by Sweat Chloride Exclusion Daytime use of Oxygen Therapy Documented history of drug abuse within the last year Subjects should not have a pulmonary exacerbation or changes in therapy for pulmonary disease within 28 days before receiving the first dose of study drug. Cirrhosis or elevated liver transaminases > 3X ULN GFR < 50 estimated by Cockroft-Gault Any illness or abnormal lab finding that, in the opinion of the investigator might confound the results of the study or pose an additional risk in administering study drug to the subject. Pregnant or Breastfeeding Subjects taking any inhibitors or inducers of CYP3A4, including certain herbal medications and grapefruit juice. (Excluded medications and foods including the drugs and foods are provided in the appendix document) Uncontrolled Diabetes Clinically significant arrhythmias or conduction abnormalities that in the opinion of the investigator that affect patient safety

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Ivacaftor (VX770)<br>Ivacaftor (VX-770) for the Treatment of Chronic Bronchitis with CFTR Dysfunction | Drug: Ivacaftor (VX-770)<br>* of Ivacaftor (VX-770) for the Treatment of Chronic Bronchitis with CFTR Dysfunction<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in lung function |  | 1 year |