Relationship Between Serum N/OFQ and Brain-heart Syndrome

Study Overview
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Brief Summary
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Choosing the neurology patients in the Second Hospital of Shanxi Medical University, diagnosed with patients with cerebral syndrome into the experimental group; patients who did not have cerebral syndrome included in the control group, and all selected people had no intimate relationship with each other.Specimen collecting control group and the study group serum inflammatory factor IL-6, solvent peptide and catecholamine content. The difference between the two groups of data was observed.According to the literature, it is guess: The solitary peptide content of the experimental group will be higher than the control group, and is positively correlated with IL-6, catecholamine content.The difference was statistically significant.

Official Title
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Relationship Between Serum N/OFQ and Cerebral Cardiac Syndrome After Stroke

Conditions
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Cerebral-Cardiac Syndrome

Intervention / Treatment
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* Diagnostic Test: Enzyme-linked immunosorbent assay


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnostic criteria in compliance with cerebral syndrome Acute ischemic stroke patients in line with the Chinese Acute Ischemic Stroke Treatment Guide 2018 related diagnostic criteria There is no intimate relationship between all selected people and knows this study, and signs informed consent Exclusion Criteria: Heart-type cerebral infarction, hemorrhagic stroke, brain tumor and past intracranial hemorrhage Complicated with severe cardiovascular complications (such as coronary heart disease, acute coronary syndrome, acute myocardial infarction, chronic heart failure, atrial fibrillation, etc.) Complicated with severe liver and kidney dysfunction (such as coagulous dysfunction, cirrhosis, nephrotic syndrome , Renal failure, etc.) Complicated with severe diabetes complications (such as diabetic nephropathy, diabetic foot, diabetic acidosis, high blood sugar hypertonic state, diabetes coronary heart disease, etc.) Complicated with Psychological disease Complicated with chronic obstructive pulmonary disease(COPD) BMI> 40

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| CCS group<br>Patients with cerebral syndrome diagnosed by the Second Hospital of Shanxi Medical University | Diagnostic Test: Enzyme-linked immunosorbent assay<br>* Serum N/OFQ , IL-6 and NE levels were detected.<br>|
| Control group<br>Patients who have not had a cerebral syndrome in ischemic stroke | Diagnostic Test: Enzyme-linked immunosorbent assay<br>* Serum N/OFQ , IL-6 and NE levels were detected.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| N/OFQ | Serum N/OFQ levels | 24 hours | 
| IL-6 | Serum IL-6 levels | 24 hours | 
| NE | Serum NE levels | 24 hours |