Lung Function After Abdominal Surgery

Study Overview
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Brief Summary
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The study aims to investigate changes in lung function and diffusion capacity for carbon monoxide after open and minimally invasive abdominal surgery and whether such changes can explain hypoxia after surgery. Inclusion: Patients undergoing surgery for abdominal surgery Exclusion: Dementia or cognitive impairment that makes it impossible to participate in studies. Investigation: The day before surgery and the day after surgery Primary outcome measures: Pulmonary function test with dynamic spirometry (Vital capacity, FEV1) and diffusion capacity for carbon monoxide. PaO2, PaCO2 and oxygen saturation (blood gas)

Detailed Description
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Postoperative hypoxia complicates 30% - 50% of abdominal surgeries. People at particular risk for postoperative pulmonary complications including severe hypoxia are those who undergo abdominal surgery, emergency surgery or have a respiratory failure due to chronic lung disease including obstructive sleep apnea. The cause of postoperative restrictive lung function and hypoxia is unknown. Previous studies report that PaO2 decreases by an average of 2 kPa after abdominal surgery, while PaCO2 is unchanged and vital capacity decreases by 35%. The study aims to investigate changes in lung function and diffusion capacity for carbon monoxide after open and minimally invasive abdominal surgery and whether such changes can explain hypoxia after surgery. Design: Prospective cohort study Inclusion: Patients undergoing surgery for abdominal surgery Exclusion: Dementia or cognitive impairment that makes it impossible to participate in studies. Method: The day before surgery and the day after surgery: Lung function (Vital capacity and FEV1) using box and diffusion capacity measurements and blood gas measurement Primary outcome measures: Pulmonary function test with dynamic spirometry (Vital capacity, FEV1) and diffusion capacity for carbon monoxide. PaO2, PaCO2 and oxygen saturation (blood gas) Other variables examined: age, sex, height, weight, type of surgery, type of anesthesia, smoking status, length of surgery, previously known lung disease.

Official Title
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Hypoxia, Lung Function and Diffusion Capacity After Abdominal Surgery

Conditions
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Lung Function, Postoperative Complications, Abdominal Surgery

Intervention / Treatment
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* Diagnostic Test: Lung function before and after surgery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patients (18 years old and older) scheduled for surgery in the abdomen at department of Surgery, Urology and Gynecologi, Umeå University hospital. Must be able to perform a lung function test Exclusion Criteria: • Dementia or severe cognitive impairment

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Abdominal surgery<br>People who to be operated in the abdomen are investigated before and after surgery. | Diagnostic Test: Lung function before and after surgery<br>* A diagnostic test<br>* Other names: Diffusion capacity and arterial blood gas before and after surgery.;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diffusion capacity for carbon monoxide (DLCO) | Change in DLCO | Change from baseline (the day before surgery) to postoperative day 1 or 2 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vital capacity (VC) | Change in VC | Change from baseline (the day before surgery) to postoperative day 1 or 2 | 
| Forced expiratory volume (FEV1) | Change in FEV1 | Change from baseline (the day before surgery) to postoperative day 1 or 2 | 
| Arterial PO2 | Change in arterial PO2 | Change from baseline (the day before surgery) to postoperative day 1 or 2 | 
| Arterial PCO2 | Change in arterial PCO2 | Change from baseline (the day before surgery) to postoperative day 1 or 2 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Lung function, Diffusion capacity, Postoperative complications, Abdominal surgery