linjc16/ctgov huggingface dataset:
Continuous Measurement of Intratracheal Pressure

Study Overview
=================
Brief Summary
-----------------
Continuous measurement of intratracheal pressure in mechanically ventilated infants using a fibreoptic pressure transducer in the endotracheal tube (ETT). Based on the findings, tracheal pressure can continuously be monitored in the presence of pediatric ETTs by combining ETT coefficients and the flow and airway pressure continuously measured at the proximal end of the ETT.

Official Title
-----------------
Continuous Measurement of Intratracheal Pressure in Mechanically Ventilated Infants

Conditions
-----------------
Endotracheal Pressure

Intervention / Treatment
-----------------
* Device: endotracheal tube pressure measurement probe


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children < 10 Years volume-controlled ventilation Exclusion Criteria: refusal of written informed consent severe pulmonary diseases

Ages Eligible for Study
-----------------
Minimum Age: 1 Day
Maximum Age: 10 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: endotracheal tube pressure measurement probe|The endotracheal tube pressure measurement probe is inserted into the endotracheal tube prior to intubation for measurement of tracheal pressure at the tip of the endotracheal tube.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| tracheal pressure |  | 2 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
endotracheal tube, endotracheal pressure, airway pressure, pressure drop, calculation, continuous calculation
Dose of Labeled Cholesterol for Kinetics: A Pilot Study

Study Overview
=================
Brief Summary
-----------------
This is a pilot study to determine the optimum time and dose to draw blood samples using a tracer for HDL kinetics.

Official Title
-----------------
Dose of Labeled Cholesterol and Phenylalanine for HDL Kinetics: A Pilot Study

Conditions
-----------------
Lipid Metabolism

Intervention / Treatment
-----------------
* Other: stable isotope of cholesterol


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: • Healthy men and women ages 18 - 50 Exclusion Criteria: Cardiovascular disease Metabolic disease Hematologic disorder Liver or kidney disease phenylketonuria Currently taking lipid lowering medications or any other drugs that could affect lipid metabolism

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Tracer<br> | Other: stable isotope of cholesterol<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incorporation of orally administered 13C3 cholesterol into plasma cholesterol | 13C3 cholesterol, which is labeled with a stable isotope, will be administered orally. Blood samples will be taken every 4-6 hours for 72 hours for the measurement of stable isotopic enrichment in cholesterol using gas chromatography-mass spectrometry. The study has a dual purpose: to determine the optimum oral dose of isotope, and to determine the time of peak enrichment in plasma cholesterol. | 72 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Lipid, Apolipoproteins, Cardiovascular disease risks
Radiation Exposure in Spine Intervention Under Angiography

Study Overview
=================
Brief Summary
-----------------
Evaluate radiation exposure and procedure times for continuous fluoroscopic monitoring during lumbar ESI

Detailed Description
-----------------
The purpose of this prospective study was to evaluate radiation exposure and procedure times for fluoroscopic monitoring during lumbar ESI with analyzing the differences among operators (experienced staff and trainee) and among different method for ESI.

Official Title
-----------------
Phase 3 Study of Evaluate Radiation Exposure and Procedure Times for Continuous Fluoroscopic Monitoring During Lumbar ESI

Conditions
-----------------
Low Back Pain

Intervention / Treatment
-----------------
* Radiation: Epidural steroid injection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Suspected of having radiculopathic low back pain Exclusion Criteria: Angiography is contraindicated

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Epidural Steroid injection<br>Group-Epidural Steroid injection (Intermittent) | Radiation: Epidural steroid injection<br>* Epidural steroid injection<br>|
| Experimental: Epidural Steroid Injection2<br>Group-injection under angiography (continuous) | Radiation: Epidural steroid injection<br>* Epidural steroid injection<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Radiation dose | Radiation dose of patients with spine invervention under angiography | Treatment on the day |
Effects of Visual Reconstruction on Brain Function and Structure in Children With Congenital Cataract

Study Overview
=================
Brief Summary
-----------------
Children have considerable plasticity of the visual system during the formation and maturation of various visual functions at different ages. Congenital cataracts are the leading cause of treatable blindness in children. With the continuous improvement of surgical approaches and surgical techniques, the success rate of congenital cataract surgery has been significantly improved clinically, and the visual function of children has been significantly improved after surgery. However, to date, there has been no experimental study of specific changes in the brain before and after surgery in children with congenital cataracts to explore its relationship with visual reconstruction. We aim to investigate the effects of congenital cataract surgery on the brain function and structure of children through preoperative and postoperative analysis and comparison of brain imaging such as BOLD-fMRI and DTI, and provide new ideas for the clinical treatment and prognostic assessment of this disease.

Official Title
-----------------
Effects of Visual Reconstruction on Brain Function and Structure in Children With Congenital Cataract

Conditions
-----------------
Congenital Cataracts

Intervention / Treatment
-----------------
* Device: MRI


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children with congenital cataracts Exclusion Criteria: Other oculo-cerebral and systemic diseases that may affect the outcome

Ages Eligible for Study
-----------------
Minimum Age: 3 Months
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Congenital cataracts children (0 3 years)<br>Children with congenital cataracts between the ages of 0 and 3 years | Device: MRI<br>* Brain testing of patients using MRI<br>|
| Normal children (0 3 years)<br>Children without congenital cataracts between the ages of 0 and 3 years | Device: MRI<br>* Brain testing of patients using MRI<br>|
| Congenital cataracts children (6 18 years)<br>Children with congenital cataracts between the ages of 6 and 18 years | Device: MRI<br>* Brain testing of patients using MRI<br>|
| Normal children (6 18 years)<br>Children without congenital cataracts between the ages of 6 and 18 years | Device: MRI<br>* Brain testing of patients using MRI<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from functional magnetic resonance imaging |  | 1 week before surgery , 1 month, 3 month, 6 month after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from best corrected visual acuity |  | 1 week before surgery , 1 month, 3 month, 6 month after surgery |
LOXL1 Polymorphism in Pseudoexfoliation Syndrome

Study Overview
=================
Brief Summary
-----------------
To evaluate the association profiles of the lysyl oxidase-like 1 gene polymorphisms with pseudoexfoliation syndrome in the Korean population, Genotypes of lysyl oxidase-like 1 gene were analyzed by direct sequencing.

Detailed Description
-----------------
To evaluate the association profiles of the lysyl oxidase-like 1 gene polymorphisms with pseudoexfoliation syndrome in the Korean population, peripheral blood sampling will be done from the patients with pseudoexfoliation. And genotypes of the three single nucleotide polymorphisms of lysyl oxidase-like 1 gene , rs1048661, rs3825942, rs2165241 were analyzed by direct sequencing.

Official Title
-----------------
Evaluation of LOXL1 Polymorphism in Pseudoexfoliation Syndrome in the Korean Population

Conditions
-----------------
Pseudoexfoliation Syndrome

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical diagnosis of Pseudoexfoliation Exclusion Criteria: medical condition that peripheral blood sampling cannot be done

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| pseudoexfoliation<br>The study group composted of the patients with pseudoexfoliation syndrome | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Genotypes of the three single nucleotide polymorphisms of LOXL1 (rs1048661, rs3825942, rs2165241) | Genotypes of the three single nucleotide polymorphisms of LOXL1 were analyzed by direct sequencing, after obtained from the peripheral blood sampling from patients. | about 1 year (when all patients were recruited) |
Medical Students and Psychoactive Substances Use

Study Overview
=================
Brief Summary
-----------------
Medical students are heavy users of psychoactive substances, and even if levels of use vary depending on the universities, the average levels are higher than most other students. In France, however, the use of licit or illicit substance has not been precisely described in medical students. The aim of this study was therefore to define the different modes of consumption of medical students. Methods: This study was a cross-sectional survey in medical students from the University of Montpellier, and the investigators performed a cluster analysis of data. Both medical students and residents were included. Socio-demographic, medico-psychological and addictological data were collected.

Official Title
-----------------
Medical Students and Psychoactive Substances Use: For Whom to Worry?

Conditions
-----------------
Psychoactive Substances Consumption

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: students had to be aged 18 to be medical students Exclusion criteria: - refusal

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Define the different modes of consumption | The aim of this study was therefore to define the different modes of consumption of medical students. | 1 day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Medical student, Psychoactive substances, Alcohol, Tobacco, At risk consumption
Exercise Pulseoximetry for Pre-flight Evaluation of Chronic Obstructive Pulmonary Disease (COPD) Patients

Study Overview
=================
Brief Summary
-----------------
Some patients with chronic obstructive pulmonary disease (COPD) need supplementary oxygen during air travel. Guidelines issued by The British Thoracic Society (BTS) for pre-flight evaluation do not discriminate sufficiently between those who need supplementary oxygen during flight, and those who can do without. Previous studies have indicated that decreasing hemoglobin oxygen saturation during exercise may predict in-flight hypoxemia. The objective of the present study is to examine if adding exercise oxygen desaturation to the BTS algorithm will better predict requirements for in-flight supplementary oxygen.

Detailed Description
-----------------
The British Thoracic Society (BTS) guidelines on pre-flight evaluation for patients with chronic respiratory disease is based on an algorithm where arterial oxygen saturation is the discriminating factor. It has recently been shown that this algorithm does not discriminate sufficiently between patients who need pre-flight evaluation and maybe supplementary oxygen during air travel, and those who can travel by air without supplemental oxygen or further evaluation. Studies have also shown that exercise desaturation may predict in-flight hypoxemia. The objective of the present study is to examine if inclusion of arterial oxygen saturation measured by pulseoximetry during exercise in the BTS algorithm, will increase the sensitivity and specificity of the BTS pre-flight evaluation guidelines.The study also include questionnaires on symptoms during air travel carried out before ande after the pre-flight evaluation.

Official Title
-----------------
May Pulseoximetry During Physical Exercise Predict Hypoxemia in COPD Patients During Air Travel?

Conditions
-----------------
Chronic Obstructive Pulmonary Disease, Hypoxemia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with COPD who have performed a hypoxia altitude simulation test able to perform the 6-minute walking test Exclusion Criteria: unstable angina uncontrolled hypertension uncontrolled arrythmia patients with long-term oxygen treatment

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Chronic obstructive pulmonary disease, Hypoxemia, Pre-flight evaluation, Hypobaria, COPD, Pulseoximetry, Air travel, Exercise desaturation
Cardiometabolic Health and Inflammatory Resolution

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to determine how inflammatory resolution impacts cardiometabolic health and disease in subjects that are either lean (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2) or obese (>30.0 kg/m2).

Official Title
-----------------
Cardiometabolic Health and Inflammatory Resolution (Kardiometabol hälsa Och Inflammatorisk Resolution)

Conditions
-----------------
Volunteers

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Informed signed consent has been obtained from the volunteer. The volunteer has a BMI greater than 18.5 kg/m2 Exclusion Criteria: The study staff contacting a potential participant perceives that the individual has difficulty understanding the information. An MD determines that the individual is on too many medications to participate The individual takes a medication that is approved by the MD, but he/she is not willing or not able to wait with any potential morning medication until after their fasted blood-draw. The individual is younger than 18 years (relevant for the FAINT-1 and FAINT-2 cohorts) The individual states that they have increased bleeding tendency or are using anti-coagulant (blood thinning) medication. The individual has some form of chronic inflammation. The individual regularly uses medication that affects inflammatory resolution (e.g., low-dose aspirin). The individual uses immunosuppressive drugs (eg, methotrexate). The individual regularly consumes fish oils (omega 3). The individual has significant gastrointestinal problems. The individual smokes or uses chewing tobacco. The individual has been drinking alcohol two days before the study visit. The individual has tattoos or body piercings on the forearms and / or the stomach that can affect the examination. The individual does not follow instructions given in the research study.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Lean and metabolically healthy<br> | |
| Lean and metabolically unhealthy<br> | |
| Overweight and metabolically healthy<br> | |
| Overweight and metabolically unhealthy<br> | |
| Obese and metabolically healthy<br> | |
| Obese and metabolically unhealthy<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Inflammatory status | The inflammatory status will be studied in all 6 groups. | 2025 |
Incidence of Respiratory Depression in Cesarean Section

Study Overview
=================
Brief Summary
-----------------
This study is designed to determine the incidence and severity of respiratory depression in elective cesarean section patients who have received a spinal or epidural narcotic called duramorph for management of postoperative pain. A monitoring device called a capnograph as well as a device called a pulse oximeter is placed on the patient once in the recovery room after delivery. The capnograph monitors the carbon dioxide level that the patient breathes out as well as their respiratory rate. The pulse oximeter is a device that is taped on the patient's finger and measures their oxygen saturation level. The monitoring is maintained for 18-24 hours after surgery.

Official Title
-----------------
A Prospective, Observational, Double-blind (Black-Box) Study Evaluating Incidence, Severity and Predictive Factors of Respiratory Depression During Postoperative Neuraxial Opioid Analgesia in Obstetric Patients After Cesarean Delivery Using Current Standard Intermittent Postoperative Monitoring Compared to Continuous Pulse Oximetry / Capnography

Conditions
-----------------
Respiratory Depression, Postoperative Pain

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Are female >= 18 years of age and <=55 years of age with ASA class I-III Schedule for cesarean surgery Are willing and able to sign informed consent form for this study Are willing and able to follow the instruction in this study protocol Exclusion Criteria: Have known contraindication/allergy to neuraxial anesthesia or morphine. Have an ASA class > III Age > 55 years

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cesearean sections receiving duramorph<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| RESPIRATORY DEPRESSION | RESPIRATORY DEPRESSION OBSERVATION ONLY OF CURRENT PRACTICES, DOES NOT INVOLVE TREATMENT | 24 HOURS | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
postoperative pain management, respiratory depression, capnography, duramorph
Evaluation of Adjunctive EndoAnchors for EVAR and TEVAR

Study Overview
=================
Brief Summary
-----------------
EndoAnchors (Heli-FX device, Medtronic, Santa Rosa) have beed described to improve fixation (mimicking an open surgical anastomosis) during or after EVAR/TEVAR. The investigators want to describe the outcomes of all consecutive patients treated with this device (retrospective and prospective data - observational study)

Detailed Description
-----------------
EndoAnchors (Heli-FX device, Medtronic, Santa Rosa) have beed designed to improve the Endovascular aortic repair. This device is described to mimic an open surgical anastomosis during or after EVAR/TEVAR. The investigators want to describe the outcomes of all consecutive patients treated with this device (retrospective and prospective data - observational study), these outcomes will be described in terms of type IA Endoleaks, migration and sac regression.

Official Title
-----------------
Evaluation of Adjunctive Use of EndoAnchors During of After EVAR and TEVAR

Conditions
-----------------
Aortic Aneurysm, Thoracic Aortic Aneurysm

Intervention / Treatment
-----------------
* Device: ESAR (Endosutured Aneurysm Repair)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All consecutive patients with adjunctive use of EndoAnchors during or after EVAR and TEVAR Exclusion Criteria: Patients that don't want te receive any repair for their disease
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: ESAR (Endosutured Aneurysm Repair)|EndoAnchors adjunctive therapy for EVAR and TEVAR|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of participants with type IA Endoleaks | Absence of type IA Endoleaks during follow-up | Three years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of participants with Endograft Migration | Analysis of Endograft migration during follow-up | Three years | 
| Rate of participants with Sac regression | Analysis of Sac regression during follow-up | Three years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Endoanchors, EVAR, TEVAR