linjc16/ctgov huggingface dataset:
Breath Gas Measurement of Propofol During Anesthesia in Patients With Endourological Procedures

Study Overview
=================
Brief Summary
-----------------
Propofol can be measured continuously in breath gas during anesthesia. This study compares propofol concentration in plasma and breath gas and processed electroencephalographic monitoring (bispectral index) under clinical conditions with patients and total intravenous anesthesia. Target controlled infusion technique is used to deliver adequate propofol concentration in plasma.

Official Title
-----------------
Study to Estimate Central Propofol Effect by Measuring Exhaled Propofol Concentrations in Patients

Conditions
-----------------
Urological Disease

Intervention / Treatment
-----------------
* Device: Drug: Propofol Anesthesia Patients will undergo propofol anesthesia.


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: • 18 years of age Written informed consent Ability and willingness to give written informed consent American Society of Anesthesiologists (ASA) risk score I-II Exclusion Criteria: Denial of the patient Patients ASA physical status III- IV Pregnancy Volunteers with history of neurological disease or stroke Volunteers with a history of recreational drug abuse Volunteers with a history of alcohol abuse Known drug allergies History of adverse events during general anesthesia Total intravenous anesthesia not practicable

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: propofol<br>Propofol Patients will receive propofol anesthesia on the study day | Device: Drug: Propofol Anesthesia Patients will undergo propofol anesthesia.<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Exhaled propofol (parts per billion) |  | Continuous measurement over 40 min during the induction of anesthesia and 30 min during recovery of anesthesia |
Social Dysfunction and Brain Dysfunction in Patients With Schizophrenia

Study Overview
=================
Brief Summary
-----------------
There were a few studies about the relationship of structural or functional abnormalities of brain and social cognitive dysfunctions in patients with schizophrenia. In addition, default network, which increases activity during mental explorations referenced to oneself including remembering, considering hypothetical social interactions, and thinking about one's own future, may be associated with social cognitive dysfunctions in patients with schizophrenia. Therefore, we will investigate the dysfunction of default network in patients with schizophrenia compared with healthy controls and the effect of default network dysfunctions on the social cognition in patients with schizophrenia.

Official Title
-----------------
Resting-state Magnetic Resonance Imaging of Brain in Patients With Schizophrenia Compared With Healthy Controls to Prove the Association Between Social Cognition Dysfunction and Abnormality of Brain Function

Conditions
-----------------
Schizophrenia, Social Cognition

Participation Criteria
=================
Eligibility Criteria
-----------------
Patients group inclusion criteria: Right-handed Intelligent Quotient(IQ) above 80 can read and understand the informed consent schizophrenia patients who was diagnosed from Structured Clinical Interview for Diagnostical and Statistical Manual of Mental Disorder 4th edition(DSM-IV, nonpatient version(SCID-NP) scales patient who has had reality distortion symptoms (like delusion or hallucination) in 5 years Control group inclusion criteria : Right-handed IQ above 80 do not have any diagnosis from SCID-NP scales do not have any family members who have psychiatric disorder Exclusion criteria: have Illness which can affect brain structures and functions can't be taken magnetic resonance imaging(MRI)

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients<br>Schizophrenia group | |
| Control<br>Healthy control group | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of resting state functional MRI between schizophrenia patients and healthy controls | After subjects are enrolled the study, functional MRI of the brain will be measured on rest. They will lie down in MRI machine and just open their eyes. There is no tasks for functional MRI. Unless the subject don't have any contraindication for MRI, they can be take MRI of brain safely. Resting-state functional brain MRI Data from subjects will be analysed statistically. We will use programs for image processing and statistical work, such as REST, Statistical Parametric Mapping(SPM), Freesurfer. For comparison between two groups, student t-test will be used. | Baseline |
Epidemiology of Merkel Carcinomas in the Bas-Rhin

Study Overview
=================
Brief Summary
-----------------
The aim of this work is to study demographic, clinical, management (diagnostic and therapeutic) and survival data concerning patients with Merkel's carcinoma in the Lower Rhine, thus obtaining the first French data.

Official Title
-----------------
Epidemiology of Merkel Carcinomas in the Bas-Rhin From 1983 to 2011: General Population Study Based on the Bas-Rhin Cancer Registry

Conditions
-----------------
Merkel Carcinoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age >18 years Diagnosis of primary Merkel carcinoma (topographic code C44 morphological code 8247/3) Diagnosis made between 1983 and 2011 Patient residing in the Bas-Rhin at the date of diagnosis Patient who has given his consent for the use of his data for research purposes Exclusion Criteria: - Refusal to participate in research

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Retrospective study of demographic, clinical, management (diagnostic and therapeutic) and survival data for patients with Merkel carcinoma in the Lower Rhine region |  | The period from from January 1st, 1983 to December 31st, 2011 will be examined | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Merkel carcinoma
Intracavernosal Injection of Papaverine/Verapamil Versus Papaverine/Phentolamine in Erectile Dysfunction

Study Overview
=================
Brief Summary
-----------------
Introduction: Erectile dysfunction is a common condition with a significant effect on quality of life. Verapamil is calcium channel blocker of the phenyl alkylamine class which relaxes the tone of the smooth muscles lining blood vessels, leading to their dilatation.

Detailed Description
-----------------
Objective: Evaluating the effect of intracavernosal injection of (Papaverine + Verapamil) and comparing it with (Papaverine + Phentolamine) in patients with erectile dysfunction. Patients and methods: Each one of the 20 erectile dysfunction patients was subjected to intracavernosal injection with (30mg Papaverine + 1mg Phentolamine), where penile duplex & clinical evaluation was carried out followed by a wash out interval of 2 weeks after which each patient was subjected to the exact previous procedures using (30 mg Papaverine + 5 mg Verapamil). Keywords: Erectile dysfunction - Intracavernosal injection - Penile duplex - Phentolamine - Verapamil.

Official Title
-----------------
Intracavernosal Injection of Papaverine/Verapamil Versus Papaverine/Phentolamine in Erectile Dysfunction: A Pilot Study

Conditions
-----------------
Erectile Dysfunction

Intervention / Treatment
-----------------
* Drug: Verapamil


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Married male patients suffering from erectile dysfunction and scheduled for intracavernosal injection. Exclusion Criteria: Responders to PDE5-inhibitors; congenital or acquired penile anomalies; uncontrolled medical conditions or known hypersensitivity to verapamil; Peyronie's disease and any known bleeding or coagulation disorders.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Verapamil<br>Intracavernosal injection of Verapamil | Drug: Verapamil<br>* Local treatment of erectile dysfunction<br>* Other names: Calcium Channel Blocker;|
| Phentolamine<br>Intracavernosal injection of Phentolamine to treat erectile dysfunction for a period of 2 wweks | Drug: Verapamil<br>* Local treatment of erectile dysfunction<br>* Other names: Calcium Channel Blocker;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| IIEF5 | Questionnaire | 6 months |
Sentinel Node With Ultrasound Contrast in Melanoma

Study Overview
=================
Brief Summary
-----------------
The purpose is to evaluate,in 20 patients, if the sentinel node(s) in melanoma can be detected by lymph contrast ultrasound. In comparing the patients will also get lymph-scintigraphy and sentinel node detection wiht blue dye. The goal is to improve the method for detecting sentinel node(s) in melanoma.

Official Title
-----------------
Sentinel Node Diagnostics With Ultrasound Contrast in Melanoma

Conditions
-----------------
Malignant Melanoma

Intervention / Treatment
-----------------
* Drug: ultrasound contrast


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Malignant melanoma on a extremity, No spread of the cancer, Patients over 18 years old, Exclusion Criteria: Pregnancy, Lactating, Severe hart disease,

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: ultrasound contrast|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Vitamin D Level and Emergence Delirium in Children

Study Overview
=================
Brief Summary
-----------------
In our study, we aimed to evaluate the relationship between vitamin D levels and postoperative delirium in children who had undergone tonsillectomy and/or adenoidectomy.

Detailed Description
-----------------
Patients are assigned to one of two groups. Serum 25(OH)D level will be determined as <12 ng/ml group 1, group 2 with ≥12 ng/ml. ASA I-II children aged 2-10 years who will undergo adenoidectomy and/or tonsillectomy surgery under general anesthesia will be included in the study. In the operating room, the patient will monitored using electrocardiography, pulse oximetry, noninvasive blood pressure measurements, capnography. Under anesthesia, blood samples were taken for serum 25(OH)D levels. After extubation, patients will be taken to the recovery room. Delirium will be evaluated using the PAED (Pediatric Anesthesia Emergence Delirium) scale at 10-minute intervals in the recovery unit. In our study, 25(OH)D level was measured.

Official Title
-----------------
Evaluation of the Relationship Between Vitamin D Level and Emergence Delirium in Children Undergoing Tonsillectomy and/or Adenoidectomy

Conditions
-----------------
Delirium

Intervention / Treatment
-----------------
* Diagnostic Test: PAED


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: American Society of Anesthesiologists physical status I and II Tonsillectomy and/or Adenoidectomy Surgery Exclusion Criteria: psychological disorders emotional disorders abnormal cognitive development developmental delay allergy to the drugs in our protocol

Ages Eligible for Study
-----------------
Minimum Age: 2 Years
Maximum Age: 10 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1<br>Serum 25(OH)D levels <12 ng/ml | Diagnostic Test: PAED<br>* Delirium positive or negative<br>|
| Group 2<br>Serum 25(OH)D levels ≥12 ng/ml | Diagnostic Test: PAED<br>* Delirium positive or negative<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The scale of emergence delirium | After extubation, when spontaneous eye opening and extremity movement started, the patients were taken to the recovery room. The patients were evaluated with PAED (Pediatric Anesthesia Emergence Delirium) in the recovery unit. PAED scores were recorded at the time of admission to the postoperative recovery unit and at 10-minute intervals. Patients with a PAED score of 10 and above in any measurement during this time period were recorded as delirium positive. | up to 30 minutes after arrival in postanesthetic care unit |
A Pilot Study of Diabetes Risk Reduction Program With WIC Mothers(The Special Supplemental Nutrition Program for Women, Infants, and Children) Overweight WIC Mothers

Study Overview
=================
Brief Summary
-----------------
1) to evaluate treatment fidelity of DRRP: study design, training of interventionists, delivery and receipt of the intervention, and application of the intervention in real-life settings; 2) to identify successful strategies for participant recruitment and maintaining active participation; 3) to collect and analyze preliminary indicators of DRRP's effect on dietary intake, physical activity, stress responses, and body weight; and 4) To evaluate sample representativeness of the target audience, implementation and acceptability of DRRP, and attrition rate.

Official Title
-----------------
A Pilot Study of Diabetes Risk Reduction Program With Overweight WIC Mothers

Conditions
-----------------
Prevention of Weight Gain

Intervention / Treatment
-----------------
* Other: lifestyle intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria:Non-pregnant women between 18 and 34 years old who understood and spoke English and had a measured BMI between 25.0 and 39.9 kg/m2 were eligible for this study. Additional inclusion criteria included having a youngest child between 6 weeks and 3.5 years of age enrolled in one of our three collaborating WIC locations, not planning to become pregnant or change WIC clinics during the study, providing accurate contact information, agreeing to notify researchers with changes in contact information or pregnancy status, willingness to accept randomized participation assignments, being willing to participate in the project for 1.5 years, and consenting to have blood glucose tested via finger stick. Exclusion Criteria: women with fasting blood glucose greater than 126 mg/dl or random blood glucose greater than 200 mg/dl, self-reported type 1 or 2 diabetes or an eating disorder, or inability to walk more than one block without resting or shortness of breath were excluded. Eligible participants provided their individual telephone and address and a telephone number of one back-up contact (relative, friend, or neighbor).

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 34 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: lifestyle intervention<br>Control group: usual WIC care | Other: lifestyle intervention<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| body weight |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| dietary fat intake, fruit and vegetable intake, physical activity, stress, affects |  |  |
Evaluation of a Smartphone Application, GoCheckKids™ as a Photo Screening Tool in a Pediatric Population

Study Overview
=================
Brief Summary
-----------------
Objective: Prospective evaluation of GoCheckKids™, a smartphone application ('App') as a photo screening device in a pediatric population to detect amblyopia risk factors (ARFs) Method: Photorefraction images are captured using up to 4 different devices with GoCheckKids™ App and patients are evaluated with cycloplegic refraction.

Official Title
-----------------
Prospective Evaluation of a Smartphone Application, GoCheckKids™ as a Photo Screening Tool in a Pediatric Population

Conditions
-----------------
Amblyopia

Intervention / Treatment
-----------------
* Device: GoCheck Kids (iOS)
* Device: GoCheck Kids (Windows)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 12 months to 6 years inclusive. Informed consent given by parent or legal guardian. Exclusion Criteria: History of ocular surgery and any condition that would preclude the ability of the investigator to obtain a reliable image and measurement

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 6 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Photorefraction of ages 1 to 6 years<br>Clinical Validation of GoCheck Kids Smartphone App | Device: GoCheck Kids (iOS)<br>* Photorefraction method is used to screen amblyopia risk factors.<br>Device: GoCheck Kids (Windows)<br>* Photorefraction method is used to screen amblyopia risk factors.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sensitivity and specificity of amblyopia risk factors detected by photo refraction | Identification of risk factors as compared to gold standard cycloplegic refraction | 1 Day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with gaze error identified by photo screening | Detection of gaze error compared to cover test examination results | 1 day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Myopia, Hyperopia, Anisometropia, Amblyopia Risk Factors, Risk Factors, Smartphone Application (App), Photoscreening, Vision Screening, Mobile Vision Screening
Mainstream Sleep Tracking Devices vs Polysomnography

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to compare two popular portable sleep monitoring devices-the Fitbit Charge®, Jawbone UP®, and SleepTime smartphone app-to the gold standard Polysomnography (PSG). Parameters that will be analyzed include sleep onset latency, sleep efficiency, and sleep staging. Specifically, this study will investigate the validity of the Jawbone UP®, Fitbit Charge®, and SleepTime app in detecting sleep and wakefulness in comparison to conventional Polysomnography (PSG).

Official Title
-----------------
Sensitivity and Specificity of Mainstream Sleep Tracking Devices Compared to Polysomnography

Conditions
-----------------
Severe Sleep Apnea, Severe Insomnia, Epileptiform Activity

Intervention / Treatment
-----------------
* Device: Polysomnography Data
* Device: Jawbone UP®
* Device: Fitbit Charge ®


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients undergoing Polysomnography Exclusion Criteria: severe sleep apnea severe insomnia with less than two hours of sleep per night epileptiform activity electrical status epilepticus of sleep

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Patients undergoing Polysomnography<br> | Device: Polysomnography Data<br> <br> Device: Jawbone UP®<br> <br> Device: Fitbit Charge ®<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time it takes subject to fall asleep |  | Up to 3 Months | 
| Number of Minutes of Sleep |  | Up to 3 Months | 
| Number of Arousals |  | Up to 3 Months |