Effects of Calamansi on Blood Glucose

Study Overview
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Brief Summary
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It is important to bring the blood glucose levels of those with type 2 diabetes mellitus (T2DM) back to normal levels as this can stop the condition from worsening and prevent other conditions that are related to T2DM from developing. One way to maintain healthy blood glucose level is the use of the glycaemic index (GI), which ranks food according to how the body responds to its carbohydrate content. Low GI foods corresponds to low increase in blood glucose levels. Calamansi is a citrus that is believed not to induce an increase in blood glucose levels. Since beverages from calamansi are available and diabetes is a health concern in the community, it is important to investigate the effect of consuming this drink. Finger prick blood were tested in order to obtain the blood glucose levels for calculating the GI for the calamansi drink.

Official Title
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Blood Glucose Response to a Calamansi Drink in Healthy Adults

Conditions
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Blood Glucose Response

Intervention / Treatment
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* Other: Calamansi
* Other: Glucose


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: non-smoker BMI between 18.5 and 24.99 kg/m2 waist circumference less than 102 cm random blood glucose less than 7.8 mmol/L negative urine dipstick result not on any medications no family history of inherited diseases no heart conditions (angina, arrhythmia or heart failure) no history of acute medical or surgical event within the past 6 months. Exclusion Criteria: pre-existing conditions such as HIV, hepatitis, inflammatory bowel diseases, diabetes mellitus, kidney disease, blood disorders (such as thalassaemia)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 21 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Reference drink<br>Healthy volunteers' blood glucose response to reference drink (glucose) | Other: Glucose<br>* 75 g of glucose dissolved in 250 ml of drinking water<br>|
| Experimental: Test drink<br>Healthy volunteers' blood glucose response to test drink (calamansi) | Other: Calamansi<br>* 250 ml of a commercially sourced calamansi drink<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline blood glucose levels | Capillary blood glucose using glucometer | 30, 60, 90, 120 min after drinking | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline urinary glucose levels | Dipstick test | 30, 60, 90, 120 min after drinking | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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glycaemic index, post-prandial blood glucose, calamansi