Effects of Low-level Laser Therapy on Global Gene Expression of Young Males Submitted to Physical Strength Training

Study Overview
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Brief Summary
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Muscle performance is largely influenced by modulations in gene expressions of muscle tissue. In this context, low-level laser therapy has been used to improve muscle performance in experimental models and human researches. Thereby, the investigators examined modulations on global gene expression of muscle tissue influenced by exercise associated to low-level laser therapy.

Detailed Description
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This study assessed muscle performance in isokinetic dynamometry and leg press device; global gene expression of muscle tissue by microarray analysis

Official Title
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Effects of Low-level Laser Therapy on Global Gene Expression of Young Males Submitted to Physical Strength Training

Conditions
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Healthy

Intervention / Treatment
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* Device: Low-level laser therapy and training
* Other: Training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy males aged between 18 and 28 years; body mass index (BMI) equal to or less than 26 kg/m2; moderated pattern of physical activity Exclusion Criteria: previous injury to the femoral quadriceps or hamstring muscles (within 6 months prior to study), osseous or articular disorder in the lower limbs, cardiovascular system disorders, systemic disease, and taking prescription medicines or using dietary supplements such as muscle mass builders

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 28 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Low-level laser therapy and training<br>Effects of low-level laser therapy on muscle performance during physical strength training and gene expression of muscle tissue. | Device: Low-level laser therapy and training<br> <br> * Other names: Low-level laser therapy;|
| Active Comparator: Training without low-level laser therapy<br>Effects of physical strength training without low-level laser therapy on muscle performance and gene expression of muscle tissue | Other: Training<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Global gene expression by microarray analysis |  | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle performance in leg press device |  | 12 weeks | 
| Muscle performance in isokinetic dynamometer |  | 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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low-level laser therapy, muscle performance, strength training, gene expression, microarrays