Long-term Health Outcomes of AE Casualties

Study Overview
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Brief Summary
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This study involves individuals who are currently participating in the Wounded Warrior Recovery Project and underwent aeromedical evacuation (AE) due to injury during deployment in Iraq or Afghanistan. The goal of the study is to understand how best to engage wounded warriors in research activities studying long-term health. Based on the results from this study, the investigators can plan a larger study with the goal to better understand the long-term health conditions of individuals who were injured in combat and improve patient care. As part of the study, participants will be asked to provide two sets of lab work over the course of a year. Each set of lab work will include one blood draw, one urine sample, and height, weight, and blood pressure measurements. In order to track long-term health, information from participants' lab work will be linked with study-related health data, as well as surveys they have completed with the Wounded Warrior Recovery Project (WWRP).

Official Title
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Prospective Evaluation of Health Outcomes in AE Casualties: a Pilot Study

Conditions
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Combat Disorders, Long Term Adverse Effects

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Combat injury during or after October 2001 Aged > 18 years Listed in EMED Underwent AE Enrolled in Wounded Warrior Recovery Project Exclusion Criteria: Non-battle injury Not listed in EMED Combat injury before October 2001 Did not undergo AE Not enrolled in Wounded Warrior Recovery Project

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of enrolled participants who complete both sets of lab work | Whether or not enrolled participants complete labs as requested at year 1 and year 2 | Approximately one year from beginning of study participation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complete blood count (CBC) | Results from this lab test will be used to define physical health outcomes of patients who have transited through the aeromedical evacuation system. | Approximately one year from beginning of study participation | 
| Comprehensive metabolic panel | Results from this lab test will be used to define physical health outcomes of patients who have transited through the aeromedical evacuation system. | Approximately one year from beginning of study participation | 
| Hemoglobin A1c | Results from this lab test will be used to define physical health outcomes of patients who have transited through the aeromedical evacuation system. | Approximately one year from beginning of study participation | 
| Cystatin C | Results from this lab test will be used to define physical health outcomes of patients who have transited through the aeromedical evacuation system. | Approximately one year from beginning of study participation | 
| High sensitivity C-reactive protein (hs-CRP) | Results from this lab test will be used to define physical health outcomes of patients who have transited through the aeromedical evacuation system. | Approximately one year from beginning of study participation | 
| B Type Natriuretic Peptide (BNP) | Results from this lab test will be used to define physical health outcomes of patients who have transited through the aeromedical evacuation system. | Approximately one year from beginning of study participation | 
| Urine microalbumin/creatinine ratio | Microalbumin and creatinine will be combined obtain this ratio in mcg/mg creatinine. Results from this lab test will be used to define physical health outcomes of patients who have transited through the aeromedical evacuation system. | Approximately one year from beginning of study participation | 
| Blood pressure | Blood pressure measurements will be used to define physical health outcomes of patients who have transited through the aeromedical evacuation system. | Approximately one year from beginning of study participation | 
| Responses from Wounded Warrior Recovery Project surveys | Surveys included in this study will include the most recent Wounded Warrior Recovery Project survey prior to study enrollment, the six month followup survey, and the one year followup survey. | Approximately one year from beginning of study participation | 
| Height | Height in feet. This measurement will be used to define physical health outcomes of patients who have transited through the aeromedical evacuation system. | Approximately one year from beginning of study participation | 
| Weight | Weight in pounds. This measurement will be used to define physical health outcomes of patients who have transited through the aeromedical evacuation system. | Approximately one year from beginning of study participation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Aeromedical Evacuation, Combat Injury