Protein Kinase N1 Level in Patients Undergoing Cardiac Surgery

Study Overview
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Brief Summary
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Acute kidney injury (AKI) is one of the most frequent major complications in patients undergoing cardiac surgery. CSA-AKI is independently related to increased perioperative mortality, increased hospital and ICU length of stay as well as heath care expenditure. Identification of relevant biomarkers may lead to early diagnosis and improve patient outcomes and health care costs. The pathophysiology of CSA-AKI is complex and ischemia-reperfusion injury is one of the important factors. Recently, it has been shown that Protein kinase N1 (PKN1) is associated with ischemia-reperfusion injury. In this study, relationship between PKN1 with the risk of CSA-AKI was analyzed and the predictive value of elevated level of PKN1 for early prediction of CSA-AKI was further evaluated.

Detailed Description
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Acute kidney injury (AKI) is one of the most frequent major complications in patients undergoing cardiac surgery. The incidence of cardiac surgery-associated AKI (CSA-AKI) varies from 5% to 42% and is the second leading cause of AKI (after sepsis) in the intensive care unit (ICU). CSA-AKI is independently related to increased perioperative mortality, increased hospital and ICU length of stay as well as heath care expenditure. Early detection of CSA-AKI could improve patient outcomes and health care costs through targeted interventions. Thus, identification of relevant biomarkers may lead to early diagnosis. The pathophysiology of CSA-AKI is complex and ischemia-reperfusion injury is one of the important factors. Recently, it has been shown that Protein kinase N1 (PKN1) is associated with ischemia-reperfusion injury. Nowadays, little is known about relationship between PKN1 and CSA-AKI. In this study, relationship between PKN1 with the risk of CSA-AKI was analyzed and the predictive value of elevated level of PKN1 for early prediction of CSA-AKI was further evaluated.

Official Title
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Protein Kinase N1 Level Predicts Acute Kidney Injury in Patients Undergoing Cardiac Surgery

Conditions
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Acute Kidney Injury, Extracorporeal Circulation; Complications, Surgery

Intervention / Treatment
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* Other: PKN1 level


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients (≥18 years old) underwent on-pump cardiac surgery admitted to ICU immediately after surgery Exclusion Criteria: Patients younger than 18 years with prior AKI end-stage kidney disease need for chronic hemodialysis pregnant patients unable to give written consent for participation

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| PKN1 Tertile 1<br> | Other: PKN1 level<br>* different PKN1 level after on-pump cardiac surgery<br>|
| PKN1 Tertile 2<br> | Other: PKN1 level<br>* different PKN1 level after on-pump cardiac surgery<br>|
| PKN1 Tertile 3<br> | Other: PKN1 level<br>* different PKN1 level after on-pump cardiac surgery<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the development of CSA-AKI | the development of CSA-AKI | 1 Week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| AKI severity | AKI stage 1，stage 2，stage 3 | 1 Week | 
| need for RRT | Reflect kidney function | 1 Week | 
| duration of AKI (≥7 days) | Reflect kidney function | 1 Week | 
| length of ICU stay | Reflect patient prognosis | up to 28 days | 
| post-operative hospital stay | Reflect patient prognosis | up to 28 days |