linjc16/ctgov huggingface dataset:
Spinal Cord Injury Series of Tampere - Retrospective Study

Study Overview
=================
Brief Summary
-----------------
This prospective study will assess thoroughly functional deficits and their significance in the light of rehabilitation in spinal cord injured patients.

Official Title
-----------------
Spinal Cord Injury Series of Tampere - Retrospective Study

Conditions
-----------------
Spinal Cord Injury

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: clinical diagnosis of spinal cord injury

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| single group study<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| all cause mortality |  | one year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
spinal cord injury(SCI), diffusion tensor imaging(DTI), tractography
Comparison of the Accuracy and Reliability of AMH, FSH and AFC in Predicting Ovarian Response

Study Overview
=================
Brief Summary
-----------------
Serum bio-markers have different prediction values for ovarian response during ovarian stimulation in-vitro fertilization

Official Title
-----------------
Comparison of the Accuracy and Reliability of AMH, FSH and AFC in Predicting Ovarian Response

Conditions
-----------------
Infertility

Intervention / Treatment
-----------------
* Other: Blood test


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age ≤ 45 years at the time of FSH starting BMI < 25 kg/m2, First IVF attempt Receiving GnRH-antagonist protocol Had oocyte retrieval Exclusion Criteria: Had ovarian stimulation or ovulation induction within 2 months prior to the study PCOS Had ovarian tumor or endometrioma Hyperprolactinemia Thyroid hormone disorders Pituitary failure Had other medical situations such as liver failure, renal failure, heart disease, diabetes, depression Had IVM

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Blood test|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of oocytes |  | At the time of oocyte retrieval | 
| number of oocytes at time of oocyte retrieval |  | up to 14 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
in-vitro fertilization, ovarian stimulation
Study to Assess the Effect of 24 Weeks of Treatment With Vildagliptin in Patients With Type 2 Diabetes

Study Overview
=================
Brief Summary
-----------------
The study will demonstrate the effect of 24 weeks of treatment with vildagliptin compared to placebo on insulin sensitivity in patients with type 2 diabetes mellitus (T2DM) treated with metformin, assessed as glucose Rd (rate of glucose disposal) during a hyperinsulinemic euglycemic clamp.

Official Title
-----------------
A Single-center,Double-blind,Randomised,Placebo-controlled,Parallel-group Study to Assess the Effect of 24 Weeks of Treatment With Vildagliptin on Insulin Sensitivity and Its Underlying Mechanism in Patients With T2DM Treated With Metformin

Conditions
-----------------
Type 2 Diabetes Mellitus

Intervention / Treatment
-----------------
* Drug: Vildagliptin
* Drug: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age in the range of 18-70 years. Patients with T2DM, diagnosed at least 6 months prior to Visit 1, who have received metformin for at least 3 months and have been on a stable dose of at least 1000mg daily for a minimum of 4 weeks prior to Visit 1. HbA1c ≤ 7.6% at Visit 1. Body mass index (BMI) in the range of 22-38kg/m2 inclusive at Visit 1. Exclusion Criteria: Pregnant or nursing (lactating) women. Patients with cardiac pacemakers or with metallic implants incompatible with magnetic resonance methodology. Congestive heart failure requiring pharmacologic treatment. Other protocol-defined inclusion/exclusion criteria may apply.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: vildagliptin<br> | Drug: Vildagliptin<br>* Dosage 50mg b.i.d.<br>|
| Experimental: Placebo<br> | Drug: Placebo<br>* 50mg bid<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measure: effect of treatment on insulin sensitivity, assessed as glucose Rd (rate of glucose disposal). |  | 24 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Diabetes mellitus, vildagliptin
Oxidative Stress and Microcirculation in Patient With Hepatic Failure Undergoing Liver Support Treatment

Study Overview
=================
Brief Summary
-----------------
Background: In patients undergoing hemodialysis or hemofiltration will suffer from the injury of reactive oxidative species. Oxidative stress will affect cell membrane, protein, and DNA. It will damage the cell and result in organ dysfunction. We believe that in patients, who have acute hepatic failure, undergoing plasma exchange or Molecular Absorbent Recirculating System for bridge therapy will suffer from the injury of reactive oxidative species, too. It will damage the kidney, lung, cerebral cortex, and other organs. It may result in death before the recovery of liver function or undergoing liver transplantation. Aims: 1. Investigate the severity of oxidative stress and risk factors of high oxidative stress in acute hepatic failure patient undergoing plasma exchange or Molecular Absorbent Recirculating System. 2. Investigate the microcirculation status and risk factors in acute hepatic failure patient undergoing plasma exchange or Molecular Absorbent Recirculating System. 3. Study the relationship between oxidative stress and microcirculation status. 4. Study the correlation between oxidative stress and prognosis. 5. Study the correlation between microcirculation status and prognosis.

Official Title
-----------------
Oxidative Stress and Microcirculation in Patient With Hepatic Failure Undergoing Liver Support Treatment

Conditions
-----------------
Liver Failure, Critical Care

Intervention / Treatment
-----------------
* Other: liver support treatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age > 18 years old Patients with acute deterioration on Chronic liver failure, who required liver support treamtment Patients with acute liver failure due to acute hepatitis, who reauired liver support treatment Patients with acute liver dysfunction within 7 days after liver transplantation, who required liver support treatment Exclusion Criteria: Age > 70 years old Cancer, not curable Patients who had used of antioxidant therapy within 24 hours before study Patients who had received hyperbaric oxygen therapy within 24 hours before study Patients who had received peroxide treatment within 24 hours before study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>patient with hepatic failure undergoing liver support treatment in surgical intensive care unit | Other: liver support treatment<br>* plasma exchange for liver support treatment<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Liver support treatment
Efficacy of Training in Manual Preparation of Platelet Rich Plasma

Study Overview
=================
Brief Summary
-----------------
This is a device study in some respects, in that specialized centrifuges are commonly used to make platelet rich plasma, and we are studying the use of standard laboratory equipment to do so. However, it is primarily interventional in that we will evaluate the percentage success of trainees in the concentration of viable platelets to more than 4X baseline using a generic speed centrifuge and a single spin method.

Official Title
-----------------
Efficacy of Training in Preparation of Platelet Rich Plasma Using a Standard Centrifuge and Manual Pipetting Methods

Conditions
-----------------
Platelet Rich Plasma Production

Intervention / Treatment
-----------------
* Procedure: Venipuncture


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: English speaking medical practitioners(N.D., D.O. or M.D.)or their office staff Exclusion Criteria: History of difficult blood draws Platelet count < 150,000 Hb < 37% History of blood disorder History of altered platelet function History of chemotherapy or radiation therapy.

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Venipuncture|Blood draw for purposes of training in platelet rich plasma concentration. Trainees will be in pairs and each will draw blood from the other for use in the concentration process.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Platelet Concentration Ability After 8 Hours of Training. | Evaluate the percentage success of trainees in the concentration of viable platelets to more than 4X baseline using a generic speed centrifuge and a single spin method. The number evaluated to determine success will be the average concentration ratio achieved in three consecutive concentrations. | 8 Hours After Onset of Training | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Retention of Platelet Concentration Ability At One Month. | Evaluate the percentage success of trainees in the concentration of viable platelets to more than 4X baseline using a generic speed centrifuge and a single spin method. The number evaluated to determine success will be the average concentration ratio achieved in three consecutive concentrations performed 30 days or longer after the training day. | Minimum 30 days after training day. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
PRP,, Platelet, Manual
Geriatric Education and Its Effect on Certain Aspects of Hospital Care of Nursing Home Patients

Study Overview
=================
Brief Summary
-----------------
Nursing home patients admitted to the hospital pose a significant challenge for health care providers. Geriatric teaching pays particular attention to these admissions and related problems. However, it is yet to be proven, whether geriatric training helps to overcome any of these issues in a better way than through non-geriatric education. The study aims to prove that geriatric training provides advantages over non-geriatric training in caring for nursing home patients admitted to the hospital.

Detailed Description
-----------------
Context: Nursing home patients admitted to the hospital pose a significant challenge for health care providers. Geriatric age, frailty, multiple readmissions, prolonged length of stay, and high mortality are just a few attributes of nursing home patients in the hospital. Geriatric teaching pays particular attention to these challenging problems. However, it is yet to be proven, whether geriatric training helps to overcome any of these issues in a better way than through non-geriatric education. Objective: To test the hypothesis that geriatric care provides advantages over non-geriatric training in caring for nursing home patients admitted to the hospital in regards to length of stay, rate of expirations and rate of readmissions. The secondary objective is to compare expirations and readmissions among patients cared for by geriatricians and non-geriatricians. Design, Setting, and Participants: Retrospective cohort study of patients admitted from Metropolitan Jewish Geriatric Nursing Home (MJGNH) to Maimonides Medical Center (MMC) over a certain period of time and under the care of geriatricians, non-geriatric internists, and surgeons. Comparison of the three study groups by age, sex, expiration rate, length of hospital stay (LOS) and readmission rate. Comparison of expired patients by age, sex and average LOS. Comparison of readmissions, expiration rate, by preservation of continuity of care, and by emergency room visits without admission.

Official Title
-----------------
Geriatric Education and Its Effect on Certain Aspects of Hospital Care of the Nursing Home Patients

Conditions
-----------------
Frail Elderly, Patient Care

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients admitted to Maimonides Medical Center (MMC) from affiliated Metropolitan Jewish Geriatric Nursing Home (MJGNH) for a 3 month period.
Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Elderly, Hospitalization, Geriatrics, Mortality, Readmission, Length of Stay
Improving Walking in Older Adults With Knee Osteoarthritis

Study Overview
=================
Brief Summary
-----------------
Knee osteoarthritis (OA) accounts for a significant proportion of mobility limitations and is one of the most disabling problems facing the growing population of older adults. The long-term objective of this research is to reduce disablement of older adults with symptomatic knee OA. The principle of specificity of training indicates that exercises that closely approximate the goal functional activity are most effective in improving physical performance during that activity. Based on this principle, the specific aim of this pilot study is to design a patient-specific gait training intervention using analysis of compensatory joint moments and energy expenditure. Successful completion will inform rehabilitation for maintaining or improving mobility as well as explore the mechanism of effect.

Official Title
-----------------
Optimizing Mobility in Older Adults With Knee Osteoarthritis

Conditions
-----------------
Knee Osteoarthritis

Intervention / Treatment
-----------------
* Other: Gait Training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Symptomatic knee osteoarthritis (knee osteoarthritis diagnosed by x-ray and frequent knee symptoms) Age 60 or older Exclusion Criteria: acute or terminal illness unstable cardiovascular condition or other medical conditions that may impair ability to participate such as pulmonary disease requiring the use of supplemental oxygen, neurological disease that affects gait, or lower limb musculoskeletal surgery in the past 6 months. Bilateral knee replacement

Ages Eligible for Study
-----------------
Minimum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Gait training | Other: Gait Training<br>* Gait training with physical therapist 2/week for 3 months<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in functional limitation assessed by the A) Summary Performance Score which includes balance tests, timed 4-meter walk, and timed chair stand test B) Timed stair climb C) Late Life Function and Disability Instrument (LLFDI) Questionnaire |  | 12 weeks | 
| Changes in the disability measure, a timed 400 meter walk |  | 12 Weeks | 
| Changes in impairments assessed using the Knee and Osteoarthritis Outcome Score (KOOS) questionnaire |  | 12 Weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Osteoarthritis, Gait training, Knee pain, Rehabilitation, Physical Therapy
Cortisol in the Treatment of Phobias

Study Overview
=================
Brief Summary
-----------------
The aim of this prospective, double-blind, placebo-controlled, randomized study is to investigate if glucocorticoid treatment, in combination with exposure therapy, helps to reduce phobic fear in patients with phobia.

Official Title
-----------------
The Efficacy of Cortisol in Combination With Behavioral Therapy in the Treatment of Phobias

Conditions
-----------------
Phobia

Intervention / Treatment
-----------------
* Drug: Cortisol


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Female and male patients with a specific phobia (fear of heights) according to DSM-IV criteria. Exclusion Criteria: Severe acute or chronic somatic diseases Psychiatric disorder other than specific phobia Topic glucocorticoid therapy (for large skin parts) Inhaled glucocorticoids Psychotropic medication Pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Cortisol|20 mg for 3 times|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| visual analog scales for fear and acrophobia questionnaires |  | 1 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
phobia, cortisol, memory, treatment
Effectivity and Safety of Endoscopic Ultrasonography-guided Laser Ablation for Refractory Neoplasms

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the safety and efficacy of endoscopic ultrasonography (EUS) guided laser ablation liver, pancreas, and retroperitoneal tumors, the investigators used preoperative and postoperative US/CEUS/CT/MRI to assess lesions, and laboratory tests including the tumor markers to evaluate the general condition of patients. Intraoperative US/CEUS/CT would be applied to monitor ablation lesions.

Conditions
-----------------
Refractory Neoplasms

Intervention / Treatment
-----------------
* Procedure: EUS-guided laser ablation for refractory neoplasms


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with refractory neoplasms including small hepatocellular carcinoma adjacent to the gastrointestinal tract, pancreatic neuroendocrine tumor, retroperitoneal tumor with less than 3 cm in diameter; Patients with Child-Pugh A/B; Patients with PLT ≥ 50*10E9/L and PT ≤ 20s. Exclusion Criteria: Patients with severe cardiopulmonary disease, intolerant endoscopy and anesthesia, upper gastrointestinal bleeding in shock, corrosive esophagitis and acute gastritis.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: EUS-guided laser ablation for refractory neoplasms<br> | Procedure: EUS-guided laser ablation for refractory neoplasms<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 80 patients of refractory neoplasms with EUS-guided laser ablation-related effectivity as assessed by MRI |  | up to 24 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Endoscopic ultrasonography, Laser ablation