Concurrent Training and Prediabetes Control

Study Overview
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Brief Summary
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Despite exercise training decrease blood fasting glicaemy in 'average' terms, there is a wide inter-individual variability after exercise training explored mainly in adults but not in adults with prediabetes comorbidities. Thus, is yet unknown the effects and influence of the concurrent training (CT) eliciting responders (R) and non-responders (NR) cases (i.e., percentage of subjects who experienced a non-change/worsened response after training in some metabolic outcomes).

Official Title
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Concurrent Training and Prediabetes Comorbidities: An Analysis of Non-responders Using Clinical Cutoff Points

Conditions
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Metabolic Disturbance

Intervention / Treatment
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* Behavioral: Endurance training plus resistant training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Written informed consent. Interested in improving health and fitness. Exclusion Criteria: Cardiovascular contraindications to exercise, History of stroke, asthma or chronic obstructive pulmonary disease, Muscle-skeletal disorders, and Smoking. A compliance rate to the exercise program ≥ 70% was required for the participants in the intervention group to be included in the statistical analyses.

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 59 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Behavioral
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Control group<br>No-exercise | Behavioral: Endurance training plus resistant training<br>* CT in women with prediabetes and co-morbidities associated. Exercise will be performed at three sessions per week. Post statistical analyses will be including analyses by the 2 groups proposed. All sessions will be supervised by an exercise physiologist during 20-weeks.<br>|
| Experimental: Endurance training plus resistant training<br>To concurrent training (endurance training plus resistant training, RT) program will be use cycle ergometers adapted for obese adults (OXFORDTM, model BE2601, OXOFORD Inc, Santiago, Chile) were used. Prior to the CT intervention, all subjects were familiarized (during 3 sessions) with the training protocols. The CT intervention included 3 weekly sessions of both ET and RT. The core part of each session included RT followed by ET exercises (for 50 and 30 minutes, respectively) and was preceded and followed by a 5-minute warm-up and cool-down with callisthenic movements. | Behavioral: Endurance training plus resistant training<br>* CT in women with prediabetes and co-morbidities associated. Exercise will be performed at three sessions per week. Post statistical analyses will be including analyses by the 2 groups proposed. All sessions will be supervised by an exercise physiologist during 20-weeks.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fasting glucose | Change from Baseline in fasting glucose | Baseline and 20-weeks immediately after the interventions ends | 
| Lipoproteins | Change from baseline in lipoproteins | Baseline and 20-weeks immediately after the interventions ends | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body mass | Change from Baseline in body mass | Baseline and 20-weeks immediately after the interventions ends | 
| Waist circumference | Change from Baseline in waist circumference | Baseline and 20-weeks immediately after the interventions ends | 
| Fat mass | Change from Baseline in fat mass | Baseline and 20-weeks immediately after the interventions ends | 
| Lean mass | Change from Baseline in lean mass | Baseline and 20-weeks immediately after the interventions ends | 
| Heart rate at rest | Change from Baseline in heart rate at rest | Baseline and 20-weeks immediately after the interventions ends | 
| Six minutes walking test | Change from Baseline in six minutes walking test | Baseline and 20-weeks immediately after the interventions ends | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Metabolic syndrome, Obesity