Gallbladder Cholesterolosis, Body Mass Index and Serum Cholesterol and Triglycerides

Study Overview
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Brief Summary
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Cholesterolosis is a common finding in biopsy specimens of gallbladders surgically removed for cholelithiasis. To the best of the investigators knowledge no study has analyzed the relationships of Body Mass Index, serum Cholesterol and Triglycerides and gallbladder cholesterolosis. The purpose of this study is to analyze and find relations between gallbladder cholesterolosis, Body Mass Index, serum cholesterol and triglycerides.

Detailed Description
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A prospective database including the following variables was filled out: Age Gender Diagnosis Weight Height Body Mass Index Histopathological results (Biopsy) Serum cholesterol Serum triglycerides All elective patients older than 15 years of age submitted to cholecystectomy for symptomatic gallstones were included. Plasma cholesterol and triglycerides levels were measured 5 to 7 days before surgery. Only patients with chronic cholecystitis and with cholesterolosis according to the histology of the surgical specimen were included, we did not include any patient with acute cholecystitis or gallbladder cancer.

Official Title
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Association of Gallbladder Cholesterolosis to Body Mass Index and Levels of Serum Cholesterol and Triglycerides.

Conditions
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Gallstones, Gallbladder Cholesterolosis

Intervention / Treatment
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* Other: Specimen biopsy and serum laboratory tests


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients submitted to elective cholecystectomy Histopathological report of gallbladder cholesterolosis Histopathological report of chronic cholecystitis Patients older than 15 years of age Exclusion Criteria: Patients younger than 15 years of age Pathological report missing from the hospital records

Ages Eligible for Study
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Minimum Age: 15 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cholesterolosis<br>I. Patients with gallbladder cholesterolosis and symptomatic cholelithiasis | Other: Specimen biopsy and serum laboratory tests<br>* Biopsy of the surgical specimens (gallbladder) submitted after cholecystectomy Laboratory tests measuring levels of plasma total cholesterol and triglycerides<br>|
| Cholelithiasis<br>II. Patients without gallbladder cholesterolosis and with symptomatic cholelithiasis | Other: Specimen biopsy and serum laboratory tests<br>* Biopsy of the surgical specimens (gallbladder) submitted after cholecystectomy Laboratory tests measuring levels of plasma total cholesterol and triglycerides<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Gallstones, Gallbladder, Cholesterolosis, Serum cholesterol, triglycerides, Body Mass Index