Study to Investigate the Receptor Occupancy of HTL0014242 Using [18F] FPEB in Healthy Male Subjects

Study Overview
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Brief Summary
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A Study in Healthy Volunteers to Investigate How a New Drug for the Treatment of Parkinson's Disease, Dystonia and Amyotrophic Lateral Sclerosis Binds to Receptor Sites in the Brain.

Detailed Description
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This is an open-label, single dose, adaptive study of orally adminstered HTL0014242 in up to 10 healthy male subjects. The primary objective is to investigate the pharmacokinetic-receptor occupancy relationship of single oral doses of HTL0014242 in healthy subjects. The secondary objectives are to assess the plasma pharmacokinetics (PK), safety and tolerability of single oral doses of HTL0014242 in healthy subjects.

Official Title
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An Open-label, Single Centre, Single Oral Dose Study to Investigate the Receptor Occupancy of HTL0014242 Using [18F] FPEB in Healthy Male Subjects

Conditions
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Healthy

Intervention / Treatment
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* Drug: HTL0014242


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy male, aged between 23 and 55 years inclusive, with body mass index between 18.5 and 32 kg/m2. Healthy on the basis of a clinical history, physical examination, electrocardiogram (ECG), vital signs and laboratory tests of blood and urine. Able to give fully informed consent and has suitable veins for cannulation and arterial access in both wrists Resting BP and heart rate within normal ranges after 5 mins rest. Exclusion Criteria: Past, current or family history of mental, behavioural or neurodevelopmental disorder. Clinically significant history or evidence of cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, neurological, immunological, pyschiatric disorders, metabolic, allergic, dermatological, haematological, pulmonary or respiratory disorder. History of significant hypersensitivity, intolerance or allergy to any drug compound, food or other substance, unless approved by Investigator. Active neoplastic disease or history of any neoplastic disease within 5 years of screening. Active infection (e.g sepsis, pneumonia, abscess) or serious infection (e.g resulting in hospitalisation or requiring parenteral antibiotic treatment) within 90 days prior to dosing. History of stomach or intestinal surgery or resection. Any of following at screening or pre-dose: QT internal heart rate correction; QRS duration >120ms; PR interval > 220ms; QTc measurements/data difficult or uninterpreable; history of additional risk factors for torsades de pointe. drug or alcohol abuse in last 2 years. Alcohol consumption is > 14 units per week Positive Urine alcohol or drug tests Positive HIV, Hep B, Hep C test Aspartate aminotransferase, Alanine aminotransferase, Gamma glutamyl transferase, Alkaline phosphatase or total bilirubin above normal upper limits Participation in other clinical trials of unlicensed medicines in the previous 3 months, or 7 half-lives of the medicine (whichever is longer) Previously dosed with HTL0014242. Intention to use or using medications that interfere with drug absorption, metabolism or elimination processes incl St John's Wort, 30 days prior to dosing. Use of ketamine, amphetamines or MDMA with 9o days prior to dosing Use or intend to use any prescription or non-prescription medications within 14 days or 5 half-lives of medication, prior to dosing. Investigator and study team to determine implications on safety or study procedures, on a case-by-case basis. Received live attenuated vaccination within 6 weeks prior to Screening, or intends to receive vaccination during the study. Smoker or user of tobacco- or nicotine-containing products. Receipt of blood products within 2 months prior to dosing. Donation of blood / comparable blood loss 3 months prior to dosing. Abnormal Allen's circulation test result. Evaluation of arterial access indicates risk of occlusion or insufficient supply. Evaluation of venous access indicates difficulties in obtaining venous blood. Subject unable or unwilling to abstain from alcohol or caffeine-containing foods and beverages. Significant consumption of any foods or beverages containing CYP1A2 inducers with 2 weeks prior to Admission (Investigator opinion). Significant consumption of any foods or beverages containing Seville-type oranges, grapefruit, or poppy seeds within 7 days prior to baseline PET and admission (Investigator opinion). Subject, in opinion of Investigator should not participate in this study. Reply from GP, for this specific study probing psychiatric history must be received before dosing. Participation in research study or other radiation exposure (e.g workplace) which in conjunction with this study will exceed ionisation radiation exposure over 10mSv within 12 months prior to the Screening visit. Contraindication for MRI, assessed by standard pre-MRI questionnaire, that preclude subject undergoing MRI scans. Subject suffers from claustrophobia (incapable of undergoing MRI or PET scan) or needle phobia. Subject has abnormal findings per structural MRI scan at screening.

Ages Eligible for Study
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Minimum Age: 23 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Single Dose HTL0014242<br>The study consists of up to 5 dosing groups, with 2 to 3 subjects per dosing group. Each subject will receive a single oral dose of HTL0014242 in the form of solid suspension capsules (1, 5, 10, and 30mg) as required. HTL0014242 will be administered in up to 5 single dose groups, with 120mg administered in the first dosing group. | Drug: HTL0014242<br>* Solid suspension capsule<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Receptor Occupancy Endpoint | The regional brain Receptor Occupancy profile of HTL0014242, measured by Positron Emission Tomography (PET) imaging with[18F]FPEB | Day 1 post-dose timepoint | 
| Receptor Occupancy Endpoint | The regional brain Receptor Occupancy profile of HTL0014242, measured by Positron Emission Tomography (PET) imaging with[18F]FPEB | Day 2 post-dose timepoint | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cmax: Maximum plasma concentration | Pharmacokinetics | Baseline up to 14(+3) days post dose | 
| Area under the plasma-concentration curve | Pharmacokinetics | Baseline up to 14(+3) days post dose | 
| Time to Maximum plasma concentration (Tmax) of HTL0014242 | Pharmacokinetics | Baseline up to 14(+3) days post dose | 
| Half-life (t1/2) of HTL0014242 | Pharmacokinetics | Baseline up to 14(+3) days post dose | 
| Apparent total plasma clearance (CL/F) | Pharmacokinetics | Baseline up to 14(+3) days post dose | 
| Incidence of Treatment Emergent Adverse Events (TEAEs) | Safety and Tolerability | Baseline up to 14(+3) days post dose | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Single dose, Open-label, Oral