The Effect of Transcranial Direct Stimulation on Cognitive Functions of Healthy Adults

Study Overview
=================
Brief Summary
-----------------
Background: Transcranial direct current stimulation(tDCS) has been used to improve cognitive functions in healthy young adults. Purpose: To investigate the effect of TDCS application on different cortex regions on cognitive function. Methods: Sixty individuals aged 18-30 were included in the study. The participants were randomly divided into the left dorsolateral prefrontal cortex (Left DLPFC Group)(n=20), the right posterior parietal cortex (Right PPC Group)(n=20), and the sham group (Sham Group)(n=20). tDCS was applied for 20 minutes on weekdays for 2 weeks. The participants were evaluated in terms of cognitive functions with Neuropsychometric Test Battery before and after treatment.

Official Title
-----------------
The Effect Of Transcranial Direct Stimulation Applied To The Dorsolateral Prefrontal Cortex And Posterior Parietal Cortex İn Cognitive Function, Mood And Proprioception İn Healthy Adults

Conditions
-----------------
Cognitive Symptom, Healthy

Intervention / Treatment
-----------------
* Other: Transcranial Direct Current Stimulation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: being 18-30 years old Exclusion Criteria: alcohol and substance addiction previous mental illness having mental and cognitive problems a history of head trauma having cardiovascular disease.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: LEFT DLPFC<br>The anode electrode of tDCS was applied to the left DLPFC and the cathode electrode was connected to the contralateral shoulder. | Other: Transcranial Direct Current Stimulation<br>* The intervention protocols were applied using tDCS (Teknofil TESsaNova). All individuals received 2 mA of anodal tDCS for 2 weeks on weekdays. All applications were done in the form of 20-minute sessions.<br>|
| Active Comparator: RİGHT PPC<br>The anode electrode of tDCS was applied to the right PPC and the cathode electrode was connected to the contralateral shoulder. | Other: Transcranial Direct Current Stimulation<br>* The intervention protocols were applied using tDCS (Teknofil TESsaNova). All individuals received 2 mA of anodal tDCS for 2 weeks on weekdays. All applications were done in the form of 20-minute sessions.<br>|
| Sham Comparator: Sham<br>Placebo was applied by placing the electrodes in the right PPC and left DLPFC without applying current. | Other: Transcranial Direct Current Stimulation<br>* The intervention protocols were applied using tDCS (Teknofil TESsaNova). All individuals received 2 mA of anodal tDCS for 2 weeks on weekdays. All applications were done in the form of 20-minute sessions.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neuropsychiatric Test Battery | It is a test battery for getting detailed information about general cognitive status. | 3 weeks | 
| Beck Depression Scale | It measures the symptoms seen in depression such as emotional, cognitive and motivational. It includes 21 items determine a behavioral feature related to depression. Items are numbered from 0 to 3. The goal is to objectively break down the degree of symptoms. The total score of all answers is calculated as follows: 0 to 9 points: Minimally depressive symptoms 10 to 16 points: Mild depressive symptoms Between 17 and 29 points: Moderate depressive symptoms Between 30 and 63 points: Severe depressive symptoms | 3 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
tDCS, Dorsolateral Prefrontal Cortex, Posterior Parietal Cortex, Cognitive Function