Tailored Intervention to Improve Medication Adherence in Patients With Hypertension

Study Overview
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Brief Summary
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Patients with hypertension have an increased risk of stroke and myocardial infarction. However, poor adherence to treatment with antihypertensives and lipid-lowering agents occurs frequently within this patient group. The purpose of this study is to investigate whether a complex tailored intervention in a hospital setting will lead to increased medication adherence and fewer cardiovascular events when compared to a usual care group. Interventions focus on motivational interviewing, medication review and telephone follow up.

Official Title
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Pharmacist Intervention Programme in Secondary Care to Improve Medication Adherence in Patients With Hypertension

Conditions
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Hypertension

Intervention / Treatment
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* Behavioral: Complex tailored intervention
* Behavioral: Usual care


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age: 18 years or older Patients receiving ambulatory treatment for hypertension in a hospital setting The patient or a carer usually dispenses the patient's medications Patient lives in the Southern Region of Denmark Written consent Exclusion Criteria: Lives in a care home or institution Receive dose dispensed medicine from a pharmacy Medicine is dispensed by a nurse in the patient's home Correctional mental health patients

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Usual care<br>Usual care | Behavioral: Usual care<br> <br> |
| Experimental: Complex tailored intervention<br>The interventions consists of 3 elements: Medication review with recommendations focused on antihypertensives and statins and adherence to guidelines and patient´s adherence to medications Consultation with a pharmacist using motivational interviewing techniques Follow-up telephone calls one month and six months after inclusion | Behavioral: Complex tailored intervention<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percent of patients that are at least 80% adherent (Medication possession rate > 0.8) to antihypertensives and statins |  | One year from inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Non-persistence with antihypertensives and statins measured by percent of patients that are not supplied with medications for more than three continuous months |  | One year from inclusion | 
| Reduction in systolic and diastolic blood pressure |  | One year from inclusion | 
| Composite endpoint (stroke, myocardial infarction or cardiovascular death) |  | One year from inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hypertension, medication adherence, motivational interviewing