Consumption of Probiotics on Salivary Bacteria Causing Dental Caries

Study Overview
=================
Brief Summary
-----------------
Dental caries is a multifactorial disease effecting majority of the human population.One of the etiological factor causing dental caries is salivary mutans streptococci. Reducing the levels of this bacteria in the saliva can significantly reduce the incidence of dental caries. A non-invasive intervention, such as the administration of probiotics reduced the salivary mutans streptococci levels.

Detailed Description
-----------------
40 candidates were selected from a pre-determined group and were randomly assigned to two groups. Group A (n=20) was administered probiotic drink and Group B (n=20) was administered placebo for 14 consecutive days. Saliva was collected on day 1 and day 15 to compare the salivary mutans streptococci levels.

Official Title
-----------------
Evaluation of the Consumption of Probiotics on the Bacteria Causing Dental Caries: A Randomised Clinical Trial

Conditions
-----------------
Dental Caries

Intervention / Treatment
-----------------
* Biological: probiotic
* Other: placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Decayed Missing Filled Surfaces less than or equal to 6 Brushes twice daily Exclusion Criteria: undergoing orthodontic treatment topical fluoride therapy in the past 2 yrs using sugar free gums

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 25 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: probiotic<br>2 mg of probiotic powder mixed in 10 ml of distilled water | Biological: probiotic<br>* Probiotic was administered for a period of 14 consecutive days. Saliva was collected on Day 1, before intervention and on Day 15, after intervention<br>* Other names: bacillus coagulans;Other: placebo<br>* placebo was administered for a period of 14 consecutive days. Saliva was collected on Day 1, before intervention and on Day 15, after intervention<br>|
| Placebo Comparator: placebo<br>10 ml of distilled water | Biological: probiotic<br>* Probiotic was administered for a period of 14 consecutive days. Saliva was collected on Day 1, before intervention and on Day 15, after intervention<br>* Other names: bacillus coagulans;Other: placebo<br>* placebo was administered for a period of 14 consecutive days. Saliva was collected on Day 1, before intervention and on Day 15, after intervention<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| counts of streptococcus mutans after the consumption of probiotic | Human saliva was assessed for the counts of streptococcus mutans, one of the major etiological factor for dental caries | 15 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
probiotic, mutans streptococci, bacillus coagulans, caries