Ovarian Function and Reserve Parameters After Discontinuation of Long-term Use of Oral Contraception

Study Overview
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Brief Summary
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The aim of this study is to investigate whether there is a correlation between anti-Müllerian hormone during long-term use of combined oral contraceptives and the recovery time before recovered menstrual cycle after discontinuation of oral contraceptives.

Detailed Description
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Background: Hormonal contraception is widely used among women worldwide; 50-89% of all women in the Western countries use oral contraception at some point in their lives. Oral contraceptives (OC) suppress the hypothalamic-pituitary-ovarian axis through a negative feedback of ethinyl estradiol and progestins and thereby potentially influence the markers of ovarian reserve due to a suppressed release of gonadotropins, which will impair the growth of antral follicles. Methods and Materials: Participants for this studies will be included through the Fertility Assessment and Counseling Clinic, Rigshospitalet, Herlev- and Hvidovre Hospital. Inclusion criteria: Use of oral contraception (for study 3 at least during the last three years). Exclusion criteria: Known infertility, known thyroid disease. Aims: Study 3: Investigate the ovarian reserve markers after discontinuation of OC over a period of three months in women with a history of long-term OC use. The women will be followed with serial ultrasounds and blood samples and will complete a menstrual calendar.

Official Title
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Recovery of Ovarian Function and Reserve Parameters After Discontinuation of Long-term Use of Oral Contraception: Is the Recovery Period Related to AMH?

Conditions
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Oral Contraceptives, Long-term Use, AMH, Ovarian Reserve Parameters

Intervention / Treatment
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* Other: Pausing oral contraceptive


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Minimum three years of oral contraceptives. Exclusion Criteria: Known infertility, known thyroid disease.

Ages Eligible for Study
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Minimum Age: 26 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Pausing oral contraceptive|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time for recovered menstrual cycle after discontinuation of oral contraception |  | 6 months after discontinuation | 
| Ovarian reserve parameters before and after discontinuation of combined oral contraception |  | 3 months after discontinuation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between suppression of the pituitary gonodal axis during use of oral contraceptives and time for recovered menstrual cycle |  | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Oral contraceptives, long-term use, AMH, Ovarian reserve parameters