The Effects of L-arabinose in a Meal in Healthy Men

Study Overview
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Brief Summary
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The purpose of this study is to investigate the effect of a meal containing different doses of L-arabinose, on the intestinal sucrase activity after intake We measure this by measuring the glucose, insulin and c-peptide after meals. Other measurements are made (glucagon and GLP-1) to explain the correlations.

Official Title
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The Effects of L-arabinose in a Meal on Glucose Metabolism in Healthy Men

Conditions
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Glucose Metabolism

Intervention / Treatment
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* Dietary Supplement: L-arabinose - effect on glucose metabolism


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy male normal weight (BMI 18,5-25 kg/m2) 18-30 years of age Exclusion Criteria: Not healthy,including those with diabetes Mellitus, high bloodpressure, dyslipidemia or a infectious diseases (hepatitis or HIV), gastrointestinal disorders Central adipositas (defined as waist circumference > 94 cm for european men) Daily intake of vitamins and minerals, 3 months before the trail starts and during the trail. elevated alcoholcunsumption(> 21 units af alcohol pr. week) take medicine Elite athlete with intensive training given bloddonation within the last 3 months smoking

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 0% arabinose meal sucrose/starch<br>A meal containing a bon with butter and marmalade, a cup cake, The and water | Dietary Supplement: L-arabinose - effect on glucose metabolism<br>* L-arabinose is mixed into the dough of the buns and cup cakes<br>|
| Other: 5 % arabinose meal sucrose/starch<br>A meal containing a bon with butter and marmalade, a cup cake, The and water | Dietary Supplement: L-arabinose - effect on glucose metabolism<br>* L-arabinose is mixed into the dough of the buns and cup cakes<br>|
| Other: 10 % arabinose meal sucrose/starch<br>A meal containing a bon with butter and marmalade, a cup cake, The and water | Dietary Supplement: L-arabinose - effect on glucose metabolism<br>* L-arabinose is mixed into the dough of the buns and cup cakes<br>|
| Other: 0 % arabinose meal Starch<br>A meal containing two bons with butter and cheese, The and water | Dietary Supplement: L-arabinose - effect on glucose metabolism<br>* L-arabinose is mixed into the dough of the buns and cup cakes<br>|
| Other: 5 % arabinose meal starch<br>A meal containing two bons with butter and cheese, The and water | Dietary Supplement: L-arabinose - effect on glucose metabolism<br>* L-arabinose is mixed into the dough of the buns and cup cakes<br>|
| Other: 10 % arabinose meal starch<br>A meal containing two bons with butter and cheese, The and water | Dietary Supplement: L-arabinose - effect on glucose metabolism<br>* L-arabinose is mixed into the dough of the buns and cup cakes<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glucose | Level of glucose over time, The AUC, the peak value and time to peak | -15, 0, 15, 30, 45, 60, 90, 120, 180 min | 
| Insulin | Level of insulin over time, the AUC, the peak value and time to peak | -15, 0, 15, 30, 45, 60, 90, 120, 180 min | 
| C-peptide | Level of c-peptide over time, The AUC, the peak value and time to peak | -15, 0, 15, 30, 45, 60, 90, 120, 180 min | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glucagon | Level of glucagon over time, The AUC, the peak value and time to peak | -15, 0, 15, 30, 45, 60, 90, 120, 180 min | 
| GLP-1 | Level of GLP-1 over time, The AUC, the peak value and time to peak | -15, 0, 15, 30, 45, 60, 90, 120, 180 min |