Prehabilitation Physical Activity in Persons With Osteoarthritis

Study Overview
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Brief Summary
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Knee joint osteoarthritis (OA) reduces functional mobility and performance of daily tasks such as rising from a chair. Therefore interventions aimed at improving muscle strength and sit-to-stand task performance are very important for these patients. The effect of exercise programs, including home exercise programs (HEP), on muscle strength, joint pain and function is well known and widely researched, yet not many studies have investigated the effect of an HEP on electromyographic activity (EMG) of muscles when performing everyday tasks, such as rising from and sitting on a chair. The aim of this study was to investigate effect of prehabilitation in women with severe knee joint OA scheduled for knee joint arthroplasty (TKA).

Official Title
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Prehabilitation Physical Activity: Relationship With Muscle Function, Postural Stability and Postoperative Recovery in Persons With Osteoarthritis

Conditions
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Osteoarthritis

Intervention / Treatment
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* Other: therapeutical exercises


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: For OA patients: patients with severe knee joint OA undergoing unilateral total knee arthroplasty (TKA) for controls: pain of joints more than 20/100 mm by VAS Exclusion Criteria: For both groups: previous total joint arthroplasty of lower limbs other musculoskeletal, neurological and cardiovascular diseases any diseases affecting balance and coordination.

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Home Exercise Program<br>8- week therapeutical exercise program performing at home for women with knee joint osteoarthritis | Other: therapeutical exercises<br>* Participants of experimental group performs daily an 8-week home therapeutical exercise program. Exercises are periodized by weeks (1-8 weeks). The aim of program is the leg muscle strengthening using an elastic band (Thera-Band, System of Progressive Exercise, USA), body balance training, and leg muscle stretching.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle electromyographic (EMG) activity | Electromyographic (EMG) activity of thigh muscles during gait and sit to stand task (amplitude, mV) | up to 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Knee joint pain intensity | Self-reported knee joint pain intensity measured by visual-analogue scale (VAS) (in mm: 0 mm - no pain and 100 mm - extreme pain) | up to 12 months | 
| Knee joint function | Self-reported functional status measured by Knee Injury and Osteoarthritis Outcome Score (KOOS) - Symptoms, Pain, Daily Living Activity, Sport and Recreational Activity. Quality of Life. Maximum is 100 points (complains are absent) and minimum is 0 points (extreme complains) | up to 12 months | 
| Sit to Stand test | five time Sit to Stand test from standard chair (s) | up to 12 months | 
| Mobility test | Timed Up and Go test, 3-m plus return 3-m walking test (s) | up to 12 months | 
| Leg muscles strength | strength of leg extensor muscles (N) | up to 12 months | 
| Body balance | Body postural sway measuring during standing using Kistler force plate (Switzerland) (mm), eyes open and eyes closed | up to 12 months | 
| Gait pattern | Gait kinematic characteristics measurement using three-dimensional movement analysis system and six optoelectronic cameras (BTS S.p.A. Italy) - joint angles (degrees) | up to 12 months |