Postoperative Sleep Quality in Patients Undergoing Thoracic Surgery With Different Types of Anesthesia Management

Study Overview
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Brief Summary
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We designed a study to determine whether a single dose of dexmedetomidine or thoracic epidural anesthesia combined with general anesthesia would provide hemodynamic stability, reduce stress hormone responses, inhibit inflammatory cytokine secretion, and improve sleep quality in patients after thoracic surgery.

Detailed Description
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We designed a prospective, single-blinded, randomized, and controlled study to determine whether a single dose of dexmedetomidine or thoracic epidural anesthesia combined with general anesthesia would provide hemodynamic stability, reduce stress hormone responses, inhibit inflammatory cytokine secretion, and improve sleep quality in patients after thoracic surgery.

Official Title
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Postoperative Sleep Quality in Patients Undergoing Thoracic Surgery With Different Types of Anesthesia Management

Conditions
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General Anesthesia, Thoracic Epidural Anesthesia

Intervention / Treatment
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* Drug: general anesthesia combined with dexmedetomidine infusion
* Procedure: general anesthesia combined with TEA


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: lung surgery one-lung ventilation. Exclusion Criteria: body mass index exceeding 30 kg/m2, autonomic dysfunction, cardiovascular disease, neurological or psychiatric diseases

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: the control group (Group C)<br>general anesthesia | |
| Experimental: general anesthesia combined with dexmedetomidine infusion<br>general anesthesia combined with 1 μg/kg dexmedetomidine infusion after induction (Group D) | Drug: general anesthesia combined with dexmedetomidine infusion<br>* general anesthesia combined with 1 μg/kg dexmedetomidine infusion after induction (Group D)<br>|
| Experimental: general anesthesia combined with TEA<br>general anesthesia combined with TEA (Group E) | Procedure: general anesthesia combined with TEA<br>* general anesthesia combined with TEA (Group E)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| inflammatory cytokine secretion and postoperative sleep quality | Primary outcomes were inflammatory cytokine secretion and postoperative sleep quality, which was measured with the BIS data on first and second postoperative nights. | immediately before anesthesia (T1), 5 min after endotracheal intubation (T2), immediately after incision (T3), 5 min after OLV initiation (T4), 5 min after double-lung ventilation initiation (T5), and immediately after extubation (T6) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| amine secretion during the surgical period and hemodynamic stability | amine (epinephrine and norepinephrine) secretion during the surgical period and hemodynamic stability | immediately before anesthesia (T1), 5 min after endotracheal intubation (T2), immediately after incision (T3), 5 min after OLV initiation (T4), 5 min after double-lung ventilation initiation (T5), and immediately after extubation (T6) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dexmedetomidine, thoracic epidural anesthesia