linjc16/ctgov huggingface dataset:
ADMA and Mechanical Ventilation in Preterm Infants

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to study the relation between mechanical ventilation and ADMA concentrations at birth.

Detailed Description
-----------------
Nitric oxide (NO) plays an important role in the normal development and maturation of the lungs. In addition, NO is an important mediator of vascular smooth muscle relaxation, ventilation perfusion matching, neurotransmission and host defence and bacteriostasis. Asymmetric dimethylarginine (ADMA) is an endogenous derivative of arginine that inhibits NOS and thereby the bioavailability of NO. Preterm infants have increased concentrations of ADMA. Therefore, inhibition of NO by increased concentrations of ADMA which could be associated with reduced pulmonary functioning.

Official Title
-----------------
Plasma ADMA Concentrations at Birth and Mechanical Ventilation in Preterm Infants

Conditions
-----------------
Premature Birth

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Gestational age < 32 weeks Birth weight < 1500 gram Written informed consent of parents Exclusion Criteria: Congenital abnormalities Chromosomal abnormalities

Ages Eligible for Study
-----------------
Maximum Age: 32 Weeks

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
ADMA, Preterms, infants, mechanical ventilation, Preterm infants
Use of Alternative Medicine Among Outpatients in Dermatology and Primary Care Clinics

Study Overview
=================
Brief Summary
-----------------
This study is to assess the practice of complementary and alternative medicine (CAM) for skin related conditions among patients in the Primary Care and Dermatology clinics.

Detailed Description
-----------------
This study aims to determine the prevalence and characteristics complementary and alternative medicine (CAM) usage among Primary Care and Dermatology clinic patients through the use of an anonymous, self-completed written survey. This survey will assess the prevalence and regularity of CAM usage (with and without concurrent use of allopathic therapies), the reasons for CAM usage, perceived success with CAM usage, and socioeconomic status, in both Dermatology and Primary Care patients. We will then compare these elements of CAM usage between the two clinic patient populations.

Official Title
-----------------
Use of Alternative Medicine Among Outpatients in Dermatology and Primary Care Clinics

Conditions
-----------------
Dermatologic Disorders

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years or older Presents for a clinic appointment with a dermatologist or primary care physician English-speaking Exclusion Criteria: Less than 18 years or older Non-English speaking

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Dermatology Clinic Patients<br>Patient attending dermatology clinics | |
| Primary Clinic Patients<br>Patient attending primary care clinics | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of complementary and alternative medicine usage among patients in the clinics | At the clinic appointment, patients will be given a survey that asks about whether the patient uses complementary and alternative medicine for skin related issues. | 5 minutes to complete survey | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Characteristics of the patients complementary and alternative medicine use | Patients who practice complementary and alternative medicine will be asked about what and how they practice their complementary and alternative medicine. | 5 minutes to complete survey |
Safety and Efficacy Comparison of Minocycline Microgranules Versus Lymecycline in the Treatment of Mild to Moderate Acne

Study Overview
=================
Brief Summary
-----------------
This is a clinical trial to compare the benefits and possible adverse events of two antibiotic treatments for mild to moderate acne. It is expected that minocycline microgranules will be more effective than lymecycline with a better adverse events profile.

Official Title
-----------------
Safety and Efficacy Comparison of Minocycline Microgranules vs Lymecycline in the Treatment of Mild to Moderate Acne. Randomized, Double Blind, Parallel and Prospective Clinical Trial for 8 Weeks

Conditions
-----------------
Mild to Moderate Acne

Intervention / Treatment
-----------------
* Drug: Minocycline vs Lymecycline


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Both gender 14 to 30 years old Mild to moderate acne Face localization At least 20 non-inflammatory lesions OR At least 15 inflammatory lesions OR At least 30 total lesions AND Less than 5 nodular lesions Exclusion Criteria: Patients younger than 14 or older than 30 years old Less than 20 non-inflammatory lesions OR Less than 15 inflammatory lesions OR Less than 30 total lesions Patients with severe acne More than 5 nodular lesions OR More than 50 inflammatory lesions OR More than 125 total lesions Pregnant women Lactating women

Ages Eligible for Study
-----------------
Minimum Age: 14 Years
Maximum Age: 30 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Minocycline 100 mg<br>Minocycline | Drug: Minocycline vs Lymecycline<br>* Minocycline 100 mg OD per mouth for 8 weeks. Lymecycline 300 mg OD per mouth for 8 weeks.<br>|
| Active Comparator: Lymecycline 300 mg<br>Group B: Lymecycline | Drug: Minocycline vs Lymecycline<br>* Minocycline 100 mg OD per mouth for 8 weeks. Lymecycline 300 mg OD per mouth for 8 weeks.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of inflammatory and non-inflammatory acne lesions |  | 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of local and systemic adverse events |  | 8 weeks |
Good Prognosis Factors After Decompressive Craniectomy : a Ten-year Retrospective Study

Study Overview
=================
Brief Summary
-----------------
Decompressive craniectomy is a treatment of refractory intracranial hypertension after various etiologies : malignant ischemic stroke, traumatic brain injury, intraparenchymal hemorrhage, aneurysmal subarachnoid hemorrhage, cerebral venous thrombosis. Initially considered as a lifesaving therapy, benefits in terms of survival were shown compared to medical treatment alone. However, despite a better survival, morbidity and poor neurological outcome are frequent among survivors. The objective of the study is to identify initial good neurological outcome factors after decompressive craniectomy in a large series of patients, in order to argue surgical and intensive care decisions, considering expected benefit and quality of life.

Official Title
-----------------
Good Prognosis Factors After Decompressive Craniectomy : a Ten-year Retrospective Study

Conditions
-----------------
Decompressive Craniectomy, Brain Injuries, Treatment Outcome

Intervention / Treatment
-----------------
* Procedure: Decompressive Craniectomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients undergoing a decompressive craniectomy from 06/11/2008 to 06/15/2018 in CHRU Nancy, France. Exclusion Criteria: Infectious ou malignant disease leading to decompressive craniectomy.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Decompressive Craniectomy|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Good neurological outcome | The neurological outcome is considered good when Glasgow Outcome Score extended (GOSE) assessed 6 months after decompressive craniectomy is between 5 and 8. | 6 months after surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Decompressive craniectomy, Outcome, Brain injuries, Aneurysmal subarachnoid hemorrhage, Cerebral venous thrombosis, Intracerebral hemorrhage, Ischemic stroke, Traumatic brain injury
Papilla Suture Design Affects Papillary Postsurgical Dimensions

Study Overview
=================
Brief Summary
-----------------
The current prospective, randomized, controlled clinical trial aimed at comparing the impact of papillae suture technique on interdental papilla dimensions after periodontal surgery using a novel 3D intraoral scanning technique.

Detailed Description
-----------------
Scientific rationale for study: Choosing the appropriate suture design for periodontal surgery may affect post-surgery tissue dimension. This is a critical issue in periodontal surgery due to the grave impact papilla play on soft tissue esthetics. Principal findings: using the novel 3D scanning of the gingiva tissue show that simple interrupted suture negatively affect post-surgery papillary height and recession adjacent to the suture compared with vertical internal mattress suture. Practical implications: the study provide evidence that allows the clinician to better choose the suture design that will allow optimal healing of the papilla. Furthermore, the study presents a novel 3D scanning method to analyzed dimensional changes in the soft tissue.

Official Title
-----------------
Papilla Suture Design Affects Papillary Postsurgical Dimensions

Conditions
-----------------
Periodontal Surgery, Oral Surgery

Intervention / Treatment
-----------------
* Procedure: papila suture technique


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years or older Systemically healthy (based on health questionnaire prior to treatment) Willingness to participate in the study Clinical requirement for periodontal\ implant surgery Exclusion Criteria: Diagnosis of diabetes/heart disease, thrombocytopenia\ coagulation factors deficiency Chronic use\abuse of drugs\ alcohol Pregnancy Smoking more than 10 cigarettes per day Antibiotic consumption in the last 3 months.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Interventional Model Description: RCT parallel study
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: one arm study<br>in each case one site was assigned as control site and one site was assigned as test site. | Procedure: papila suture technique<br>* simple interupted vs internal horoizontal matress suture<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| papilary volume | changes in papilary volume using 3D scanner | 12 weeks post surgery |
Study of the Chinese Prescription Weiqi Decoction on Chronic Atrophic Gastritis

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the efficacy and safety of the Chinese prescription Weiqi decoction on Chronic Atrophic Gastritis.

Conditions
-----------------
Gastritis

Intervention / Treatment
-----------------
* Drug: Weiqi decotion


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical diagnosis of Chronic Atrophic Gastritis Male of female patients between 18-65 years old Written informed consent Exclusion Criteria: Combine with malignant pathology on epithelial dysplasia of gastric mucosa Combine with duodenal ulcer or gastric ulcer Combined with severe heart, gallbladder, kidney, endocrine system, hemopoietic system or nervous system disease. Pregnancy or breast feeding women, or unwilling to have contraception.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Weiqi decoction<br> | Drug: Weiqi decotion<br>* Decoction ,two times a day<br>|
| Placebo Comparator: low dose of Weiqi decoction<br> | Drug: Weiqi decotion<br>* Decoction ,two times a day<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Symptoms and conditions of tongue and pulse,the gastroscopy and pathological change |  | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Indicates of liver and renal function |  | 12 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
chronic atrophic gastritis, Traditional Chinese Medicine
Fluid Absorption in Patients Undergoing Operative Hysteroscopy; Results From a Prospective Controlled Study

Study Overview
=================
Brief Summary
-----------------
To determine if combining intravenous oxytocin infusion and spinal anesthesia will reduce the amount of glycine absorption in patients undergoing operative hysteroscopy

Detailed Description
-----------------
Prospective controlled study in premenopausal patients who had hysteroscopic surgery including endometrial resection, endometrial polypectomy, myomectomy resection and uterine septal resection. The effect of combined spinal anesthetic with oxytocin infusion on fluid deficit was studied.

Official Title
-----------------
The Impact of Spinal Anesthesia and Use of Oxytocin on Fluid Absorption in Patients Undergoing Operative Hysteroscopy; Results From a Prospective Controlled Study

Conditions
-----------------
Fluid Overload

Intervention / Treatment
-----------------
* Other: oxytocin and spinal anesthesia
* Other: General anesthsia


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: premenopausal with no cardiovascular comorbidities Exclusion Criteria: endometrial cancer cases, patients who received pre-operative hormonal preparations, previously resected cases and cases done using bipolar diathermy.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 49 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: oxytocin and spinal anesthesia<br>spinal anesthesia combined with intravenous oxytocin infusion | Other: oxytocin and spinal anesthesia<br>* start oxytocin 10 IU/200 ml saline at the insertion of the spinal anesthesia<br>|
| Active Comparator: general anesthsia<br>general anesthesia alone | Other: General anesthsia<br>* General anesthesia alone.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| fluid overload | Fluid (glycine) excessive absorption into the patient | 16 months |
The Course of Hip Flexion Weakness Following LLIF or ALIF

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to assess the course of hip weakness after LLIF or ALIF procedures. These outcomes include measures of hip strength using a dynamometer, which is a device used to measure muscle strength. While it is known that people experience temporary hip and leg weakness after an LLIF or ALIF, the exact timing of when hip and leg strength is regained after an LLIF or ALIF is not known.

Official Title
-----------------
The Course of Hip Flexion Weakness Following LLIF or ALIF

Conditions
-----------------
Degenerative Disc Disease, Herniated Nucleus Pulposus, Spondylolisthesis

Intervention / Treatment
-----------------
* Procedure: LLIF or ALIF procedures


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1-, 2-, or 3-level L2L3, L3L4, or L4L5 LLIF or ALIF for degenerative pathology including radiculopathy, neurogenic claudication, intervertebral disc disease, facet joint disease, degenerative spondylolisthesis, degenerative myelopathy degenerative kyphosis, and scoliosis Back and/or leg pain Failed at least 6 months of conservative treatment Exclusion Criteria: Older than 65 years of age Prior spinal fusion surgery Greater than Grade 2 spondylolisthesis Greater than 10° scoliosis History of spinal infection

Ages Eligible for Study
-----------------
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: LLIF or ALIF procedures|LLIF or ALIF procedures|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hip flexion and knee extension strength as measured by the Lafayette Instrument Manual Muscle Testing Device (Dynamometer). | Using a Lafayette Instrument Manual Muscle Testing Device (Dynamometer), we will be measuring the force in pounds a given patient can exert upon hip flexion and knee extension at the preoperative timepoint and 6 weeks, 12 weeks and 6 months postoperatively. | Assessing changes in hip flexion and leg extension strength from the preoperative baseline to postoperative measurements taken at 6 weeks, 12 weeks and 6 months following lumbar fusions. |
Craneofacial Injuries in Rink Hockey Athletes

Study Overview
=================
Brief Summary
-----------------
To collect the number of injuries that affect the face and head in rink hockey athletes prospectively during a regular season.

Detailed Description
-----------------
To collect the number of injuries that affect the face and head in rink hockey athletes prospectively during a regular season, while collecting athlete´s exposure and specifical injury characteristics (Burden, mechanism, situation, etc)

Official Title
-----------------
Epidemiology of Craneofacial Injuries in Rink Hockey Athletes

Conditions
-----------------
Head Injury, Face, Concussion, Brain

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Compete in a spanish rink hockey league play at least in one game during ther regular season Exclusion Criteria: do not accept the participation in the study
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of participants injured | nº of injuries affecting the head or face per time (X/1000h) | september 2022 to march 2023 | 
| days lost due to injury | nº of days lost due to injury affecting the head or face per time (X days/1000h) | september 2022 to march 2023 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| usage of helmet | characterise if the player was using a helmet or not when the injury happened | september 2022 to march 2023 | 
| situational characteristics of the injury | register when the injury happened (training or game) | september 2022 to march 2023 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
rink hockey, injury, epidemiology, burden
Outcome of FFR-guided Intervention Strategy

Study Overview
=================
Brief Summary
-----------------
The investigator will evaluate the clinical outcomes of the patients in whom the treatment strategy for their coronary stenosis were determined by fractional flow reserve measurement.

Detailed Description
-----------------
Inclusion criteria Coronary stenosis Successful measurement of fractional flow reserve Clinical outcomes Death Cardiac death Target lesion revascularization Target vessel revascularization

Official Title
-----------------
Clinical Outcome of Fractional Flow Reserve-guided Coronary Intervention Strategy in Koreans

Conditions
-----------------
Coronary Artery Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Coronary stenosis Successful fractional flow reserve measurement Exclusion Criteria: Contraindication to adenosine Expected life expectance < 1year

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| FFR<br>Patients with intermediate coronary stenosis Patients with successful fractional flow measurement Feasible > 9months clinical follow-up | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Long-term MACE | Cardiac death, MI, target vessel revascularization, target lesion revascularization | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Short-term MACE | Cardiac death, MI, TLR/TVR | 9 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Coronary stenosis, stent, fractional flow reserve