Predicting Acute Kidney Injury After Coronary Artery Bypass Graft

Study Overview
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Brief Summary
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Acute kidney injury after cardiac surgery is a major complication after cardiac surgery and has been reported to be associated with adverse outcome. There have been many studies reporting risk factor of acute kidney injury after cardiac surgery, but the influence of perioperative variables related to anesthesia and perioperative medication has not been evaluated fully. The investigators attempt to evaluate the influence of perioperative clinical variables including preoperative medication, preoperative albumin level, uric acid concentration, anesthesia technique, use of hydroxyethyl starch, blood glucose level, intraoperative medication, perioperative cardiac function (systolic and diastolic function) and hemodynamic variables during surgery on the incidence of acute kidney injury after coronary artery bypass graft.

Detailed Description
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Acute kidney injury (AKI) after cardiac surgery is a major complication after cardiac surgery and has been reported to be associated with adverse outcome. There have been many studies reporting risk factor of acute kidney injury after cardiac surgery, but the influence of perioperative variables related to anesthesia and perioperative medication has not been evaluated fully. The investigators attempt to evaluate the influence of preoperative medication, preoperative albumin level, uric acid concentration, NL ratio, anesthesia technique, use of hydroxyethyl starch, blood glucose level, intraoperative medication, perioperative cardiac function (systolic and diastolic) and hemodynamic variables during surgery on the incidence of acute kidney injury after coronary artery bypass graft. Preoperative and postoperative diastolic dysfunction may be associated with postoperative AKI. In addition, preoperative neutrophil-lymphocyte ratio (NLR) which has been reported to be a marked for systemic inflammation and was associated with prognosis in cardiac patients undergoing coronary artery bypass graft or percutaneous coronary intervention. This preoperative or immediate postoperative NLR might be able to predict AKI after coronary artery bypass surgery.

Official Title
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Predicting Acute Kidney Injury After Coronary Artery Bypass Graft : a Simplified Clinical Risk Scoring Model

Conditions
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Creatinine, Coronary Artery Bypass Surgery, Acute Kidney Injury, Mortality

Intervention / Treatment
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* Procedure: Coronary artery bypass surgery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients who underwent coronary artery bypass surgery during between 2010 and 2012 in Samsung Medical Center Exclusion Criteria: lack of postoperative creatinine or urine output data patients who expired within 24hours after surgery

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Coronary artery bypass surgery<br>patients who underwent coronary artery bypass surgery between 2010 and 2012 in Samsung Medical Center | Procedure: Coronary artery bypass surgery<br>* coronary artery bypass surgery<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acute kidney injury diagnosis defined by KDIGO criteria | Acute kidney injury diagnosis defined by KDIGO criteria (Stage 1, 2, 3) during seven days after surgery | during 7 days after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acute kidney injury as defined by AKIN (acute kidney injury network) criteria | Acute kidney injury as defined by AKIN (acute kidney injury network) criteria | within 48 hours after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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coronary artery bypass surgery, acute kidney injury, creatinine, mortality