linjc16/ctgov huggingface dataset:
Efficacy of Ultrasound Contrast Agent to Assess Renal Masses

Study Overview
=================
Brief Summary
-----------------
Patients with an incidentally discovered small renal masses (SRM) < 4 cm in diameter are included. All patients will undergo biopsy for tissue diagnosis. Most patients will be followed by imaging. Study intervention includes low MI US to be performed following both bolus and infusion injection of Definity contrast. Presence and absence of vascularity, pattern of vascularity, and TIC values will be correlated with the final pathology to find features differentiating benign from malignant masses.

Official Title
-----------------
The Comparison of Accuracy of Contrast Enhanced Ultrasound on Diagnosis of Small Renal Masses and Distinguishing Renal Cell Carcinomas From Other Renal Masses, With Biopsy

Conditions
-----------------
Renal Cell Carcinoma

Intervention / Treatment
-----------------
* Drug: Definity


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with newly diagnosed Renal mass < 4 cmm, who are going to undergo diagnostic CT, MRI or biopsy.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: comparison to biopsy<br>Comparing contrast enhanced US with biopsy result | Drug: Definity<br>* Definity is the contrast agent which is going to be injected in a bolus and infusion forms during the ultrasound performance.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| biopsy |  | 12 to 18 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Small renal Mass, Contrast Enhanced Ultrasound, Renal Cell Carcinoma, noninvasive diagnosis of RCC
Measurement of Multiphysical Fields at the Subject-sitting Interface

Study Overview
=================
Brief Summary
-----------------
With the population ageing and the increase in disabilities prevalence, demand for wheelchairs is increasing. Padding and shape of seat are important factors for comfort when sitting for long periods of time. Sustained mechanical loads induced by the seated stance can cause pressure ulcers in the ischial prominences. Temperature and humidity have also been shown to be important in the development of pressure ulcers.

Detailed Description
-----------------
The aim of this research is to measure the pressure, temperature and relative humidity fields at the user-seat interface of a wheelchair.

Official Title
-----------------
Measurement of Multiphysical Fields at the Subject-sitting Interface

Conditions
-----------------
Wheelchair Users

Intervention / Treatment
-----------------
* Device: instrumented wheelchair


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy subjects aged of 18 and more agreeing to participate in the study Exclusion Criteria: under 18 years old pregnant women

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| wheelchair user-seat group<br>healthy subjects agreeing to participate in the study | Device: instrumented wheelchair<br>* Measurements of pressure, temperature and humidity at the subject/cushion interface<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pressure | Pressures at the user-seat interface of a wheelchair will be measured by non-invasive method using a pressure pad positioned directly on the cushion, under the seated subject. No contact with the skin will take place | Day 0 | 
| temperature | Temperatures at the ischial tuberosities will be measured by a non-intrusive methods using sensors taped directly on the pants of the participants. No contact with the skin of the participants will take place | Day 0 | 
| humidity | Humidity at the ischial tuberosities will be measured by a non-intrusive methods using sensors taped directly on the pants of the participants. No contact with the skin of the participants will take place | Day 0 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Wheelchair, Pressure ulcers, Pressure measurement, Temperature measurement, Humidity measurement
The Impact of Resistance Training on Type 2 Diabetes Patients.

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine whether the long-term effects of high-intensity progressive resistance training could improve glucose and lipid metabolism in chinese type 2 diabetes.

Conditions
-----------------
Diabetes

Intervention / Treatment
-----------------
* Other: Resistance training
* Behavioral: Lifestyle counselling


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: established type 2 diabetes Exclusion Criteria: severe joint cardiovascular and respiratory system disease, uncontrolled hypertension (160/90 mmHg), severe diabetic nephropathy and neuropathy with severe liver and kidney dysfunction with mental system disease pregnant women or nursing mothers

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Resistance training<br>Patients of treatment group will undergo resistance training every week sessions | Other: Resistance training<br>* This training consists 4 exercises and every exercises lasts 5 seconds.<br>Behavioral: Lifestyle counselling<br>* Lifestyle counselling mainly indicates dietary instruction.<br>|
| Other: Lifestyle counseling<br>Patients of control group will get the lifestyle counseling every 3 month | Behavioral: Lifestyle counselling<br>* Lifestyle counselling mainly indicates dietary instruction.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HbA1c |  | up to six months |
Indole-3-Carbinol Effects on Estrogen Metabolism

Study Overview
=================
Brief Summary
-----------------
This study will test a dietary supplement, indole-3-carbinol, for improving the estrogen profile in women across a range of body mass index.

Official Title
-----------------
Effects of Dietary Indole-3-Carbinol on Estrogen Metabolites Across a Wide Range of Body Mass Index: Implications for the Prevention of Endometrial Cancer in Obese Women

Conditions
-----------------
Obesity

Intervention / Treatment
-----------------
* Dietary Supplement: Indole-3-carbinol


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: woman aged from 30 - 50 years regular menstrual cycle Exclusion Criteria: taking hormone replacement or hormonal contraception thyroid disorder uncontrolled asthma BMI under 18.5 allergy to cruciferous vegetables

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Indole-3-carbinol<br> | Dietary Supplement: Indole-3-carbinol<br>* 200 mg bid po X 8 weeks<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in urinary 2/16-hydroxyestrone ratio |  | 8 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
dietary supplement, indole 3 carbinol, estrogen
Measuring Patient Satisfaction and Quality of Life Following Body Image Altering Surgery

Study Overview
=================
Brief Summary
-----------------
The goal of this study is to develop a questionnaire to measure patient satisfaction with their breast surgery. This questionnaire will help surgeons better understand how patients feel about their surgical results. We hope that such a questionnaire will improve the understanding of breast surgery results and patient care.

Official Title
-----------------
Measuring Patient Satisfaction and Quality of Life Following Body Image Altering Surgery: Development and Validation of a Patient-Reported Outcomes Instrument

Conditions
-----------------
Breast Cancer, Breast Surgery, Breast Reconstruction, Breast Reduction, Breast Augmentation

Intervention / Treatment
-----------------
* Behavioral: questionnaires
* Behavioral: questionnaires


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All stages (1-4) Age > or = to 18 to 85 years. Postoperative Group: Male and Female patients who have undergone mastectomy, breast reconstruction, reduction, augmentation, bariatric or body contouring surgery between 1 month to 8 years ago Or Preoperative Group: Male and Female patients who are scheduled to undergo mastectomy, breast reconstruction, reduction, or augmentation or body contouring surgery Exclusion Criteria: Inability to speak or understand English Active psychiatric illness, cognitive or sensory impairment Physical impairment that may prevent filling out a paper and pencil survey or responding to interview questions

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Postoperative Breast Surgery Patients | Behavioral: questionnaires<br>* patients will fill out two questionnaires post surgery<br>|
| 2<br>Preoperative Breast Surgery Patients | Behavioral: questionnaires<br>* Patient will fill out questionnaire before and 3 to 6 months after treatment.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To develop and validate a new patient derived measure of satisfaction with breast surgery. |  | conclusion of study | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determining variations in satisfaction related to patient characteristics and preoperative expectations. |  | conclusion of study |
Retrospective Record-review Study in Patients Who Had Diabetic Foot Ulcer

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to evaluate the medical cost of illness for DFUs on the patients who had used ON101 or Aquacel® in the ON101CLCT02 trial.

Official Title
-----------------
A Retrospective Record-review Study in Patients Who Had Participated in the ON101CLCT02 Diabetic Foot Ulcer Trial

Conditions
-----------------
Diabetic Foot Ulcer

Intervention / Treatment
-----------------
* Drug: ON101 Cream


Participation Criteria
=================
Eligibility Criteria
-----------------
No additional inclusion or exclusion criteria will be applied.

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 79 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| ON101 Cream<br>Patients Who Had Participated in the ON101CLCT02 Diabetic Foot Ulcer Trial and assigned to ON101 Cream arm | Drug: ON101 Cream<br>* Not applicable in this retrospective study<br>|
| Aquacel® Hydrofiber® dressing<br>Patients Who Had Participated in the ON101CLCT02 Diabetic Foot Ulcer Trial and assigned to Aquacel® Hydrofiber® dressing arm | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Demographic characteristics |  | Up to two years after the patient had completed or early withdrawn from the ON101CLCT02 trial | 
| Wound characteristics of DFUs (classification and proportion) |  | Up to two years after the patient had completed or early withdrawn from the ON101CLCT02 trial | 
| Proportion of DFU recurrence after completing or withdrawing from the ON101CLCT02 trial |  | Up to two years after the patient had completed or early withdrawn from the ON101CLCT02 trial | 
| Medical costs due to DFUs |  | Up to two years after the patient had completed or early withdrawn from the ON101CLCT02 trial | 
| Proportion of wound infection, gangrene, and amputation |  | Up to two years after the patient had completed or early withdrawn from the ON101CLCT02 trial | 
| Frequency of wound infection, gangrene, and amputation |  | Up to two years after the patient had completed or early withdrawn from the ON101CLCT02 trial |
Duration of Stay After Urologic Surgery : Neuraxial Versus General Anesthesia

Study Overview
=================
Brief Summary
-----------------
Outpatient midurethral surgery is a frequent surgery. It is performed either under general anesthesia or neuraxial anesthesia. A frequent complication is postoperative urinary retention requiring urinary catheterization, which implies a higher infectious risk. The investigators compared the complication rate after TVT surgery depending on the type of anesthesia.

Official Title
-----------------
Duration of Stay for Outpatient Surgery After Tension Free Vaginal Tape (TVT) Urologic Surgery : Neuraxial Versus General Anesthesia

Conditions
-----------------
Urinary Retention

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age > 18 years Sex: Female Patient who has consented to the use of her medical data for research purposes. Patient undergoing outpatient urinary incontinence surgery using TVT between 2012 and 2016 Exclusion Criteria: Specific clinical forms of the disease, Interfering treatments and associated diseases, history, Refusal of the patient to participate in the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The investigators compared the rate of complications after TVT surgery depending on the type of anesthesia and the need for urinary catheterization, requiring longer hospital stay after surgery. | Patients hospitalized at Strasbourg University Hospital from 2012 to 2016. | The period from January 1st, 2012 to December 31st, 2016 will be examined | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Urologic surgery, Urinary incontinence, Tension Free Vaginal Tape, Post-operative urinary retention, Outpatient surgery
A Study to Determine the Degree of Additional Reduction in CV Risk in Lowering LDL Below Minimum Target Levels

Study Overview
=================
Brief Summary
-----------------
The primary objective of this study is to determine the degree of additional reduction in cardiovascular risk that was accrued to patients by lowering their LDL-C beyond the currently accepted minimum target level for patients with pre-existing CHD. Secondary objectives include the safety profile of this treatment strategy, its cost-effectiveness, effect on other atherosclerotic-related events and procedures, and total mortality.

Official Title
-----------------
The Effect Of LDL-Cholesterol, Lowering Beyond Currently Recommended Minimum Targets On Coronary Heart Disesse (CHD) Recurrence In Patients With Pre-Existing CHD

Conditions
-----------------
Cardiovascular Disease, Cerebrovascular Accident, Coronary Heart Disease

Intervention / Treatment
-----------------
* Drug: Atorvastatin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Men and women age 35-75 who have evident CHD Exclusion Criteria: Known hypersensitivity to HMG CO-A reductase therapy, liver disease, evidence of secondary hyperlipidemia

Ages Eligible for Study
-----------------
Minimum Age: 35 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Atorvastatin|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The primary outcome is the time to occurrence of a major |  |  | 
| cardiovascular event, defined as the composite outcome of the |  |  | 
| following clinical endpoints |  |  | 
| CHD death |  |  | 
| Non-fatal/Non-procedure related MI |  |  | 
| Resuscitated cardiac arrest or fatal/non-fatal stroke |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The occurrence of the following clinical events |  |  | 
| Major coronary event (CHD death, non fatal myocardial infarction or resuscitated cardiac arrest) |  |  | 
| any coronary event (major coronary event or CABG |  |  | 
| PTCA, other revascularization procedure, procedure-related myocardial infarction, or documented angina) |  |  | 
| cerebrovascular event (fatal or non fatal stroke, TIA) |  |  | 
| peripheral vascular disease; hospitalization with primary diagnosis' of CHF |  |  | 
| any cardiovascular event (any of the above); and all-cause mortality. |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Major cardiovascular event, Major Coronary event, Revascularization
Non-invasive Validation of Non-invasive Central Blood Pressure Measurements Using Oscillometric Pulse Wave Analysis

Study Overview
=================
Brief Summary
-----------------
There is growing evidence that central blood pressure is a better predictor of hypertensive end-organ damage and cardiovascular outcome than routine brachial readings. The investigators aimed to evaluate the accuracy of a novel device for the non-invasive determination of central blood pressure based on automated oscillometric radial pulse wave analysis.

Official Title
-----------------
Non-invasive Automated Central Blood Pressure Measurements Using Oscillometric Pulse Wave Analysis - Comparison With Non-Invasive Reference Values

Conditions
-----------------
Arterial Hypertension, Healthy Control, Coronary Heart Disease, Diabetes Mellitus

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: cardiovascular disease, diabetes mellitus or healthy control Exclusion Criteria: inability to give informed consent hemodynamic instability

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| cardiovascular disease<br>patients with cardiovascular disease, invasive and non-invasive determination of central blood pressure | |
| healthy controls<br>healthy controls, invasive and non-invasive determination of central blood pressure | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| agreement of systolic central blood pressure measurements |  | 15 minutes | 
| agreement of diastolic central blood pressure measurements |  | 15 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
central blood pressure, measurement, oscillometric radial pulse wave analysis
Evaluation of NICHE Programme Activities in Kenya

Study Overview
=================
Brief Summary
-----------------
This study evaluates the impact of additional cash and nutritional counselling on nutrition outcomes in pregnant women and children up to the age of two years in CT-OVC (cash transfer- orphan and vulnerable children) households in Kitui and Machakos counties of Kenya. The control arm households will receive their normal CT-OVC cash payment and the intervention arm will receive an additional cash payment and nutritional counselling.

Official Title
-----------------
Evaluation of NICHE (Nutritional Improvements Through Cash and Health Education) Programme Activities in Kitui and Machakos, Kenya

Conditions
-----------------
Growth Disorders, Malnutrition

Intervention / Treatment
-----------------
* Other: Cash and counselling


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pregnant women and children aged up to 23 months of age in households receiving CT-OVC cash transfers in Kitui and Machakos counties of Kenya Exclusion Criteria: not residing in CT-OVC households

Ages Eligible for Study
-----------------
Maximum Age: 23 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention<br>Additional cash transfer and nutritional counselling | Other: Cash and counselling<br>* Additional 500 Ksh per child per month and household visits by Community health Volunteers (CHVs)<br>|
| No Intervention: Control<br>Existing cash transfer only | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Stunting | HAZ (height for age z score) < -2 SDs of WHO median | 8-15 months |