Predictors of Infective Endocarditis Among Patients Managed for Staphylococcus Aureus Bacteremia, Particularly Staphylococcus Aureus Bacteriuria, and Time to Blood Culture Positivity

Study Overview
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Brief Summary
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Staphylococcus aureus is a frequent cause of primary or secondary bacteremia. It is also responsible for many cases of infective endocarditis, for which the therapeutic management is specific. The frequency of infective endocarditis among Staphylococcus aureus bacteremias varies between 2.7% and 23.4%. Many factors associated with the risk of developing endocarditis in patients with S. aureus bacteremia have been described. Two parameters of potential interest remain excluded from this work: blood culture growth time, a marker of bacterial inoculum, and the presence of bacteriuria, which is common during bacteremia. The objective of this study is to evaluate the interest of these two parameters in the prediction of the presence of endocarditis during S. aureus bacteremia. Investigators will conduct a retrospective study including all patients managed for Staphylococcus aureus bacteremia and in whom a urine culture was performed. The primary objective is to describe the factors associated with the occurrence of endocarditis in patients managed for S. aureus bacteremia and who received a urine cytobacteriological examination (UCE). The secondary objectives are: to evaluate the factors associated with the occurrence of S. aureus bacteriuria in patients with S. aureus bacteremia and to evaluate the risk factors for mortality in patients managed for S. aureus bacteremia.

Official Title
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Predictors of Infective Endocarditis Among Patients Managed for Staphylococcus Aureus Bacteremia, Particularly Staphylococcus Aureus Bacteriuria, and Time to Blood Culture Positivity

Conditions
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Bacteremia, Endocarditis, Bacterial

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient over 18 years of age for whom: Blood cultures returned positive for S. aureus A cytobacteriological examination of the urine was performed concomitantly with the positive blood culture for S. aureus Has been tested for infective endocarditis by echocardiography. French-speaking patient Exclusion Criteria: Patient with S. aureus bacteremia who has not had an ECBU or echocardiography performed Patient under guardianship or curatorship Patient deprived of liberty Patient under court protection Patient objecting to the use of his or her data for this research

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Factors associated with the occurrence of endocarditis | This outcome corresponds to the description of predictive factors for infective endocarditis in patients with S. aureus bacteremia. | Month 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Factors associated with the occurrence of S. aureus bacteriuria | This outcome corresponds to the comparison of patients with S. aureus bacteremia and same-germ bacteriuria to those without same-germ bacteriuria. | Month 1 | 
| Risk factors for mortality | This outcome corresponds to the comparison of patients who died in the setting of their S. aureus bacteremia to surviving patients. | Month 1 |