The Neuroprotection of Sevoflurane Preconditioning on Intracranial Aneurysm Surgery

Study Overview
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Brief Summary
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The current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery.

Detailed Description
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The current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery. The patients with cerebral aneurysm will be recruited in current study. The sevoflurane preconditioning will be performed before the surgical procedure. The neurological injury biomarkers, such as S-100b and NSE will be detected. The neurological function and recovery will be assessed after the surgery.

Official Title
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The Neuroprotection of Sevoflurane Preconditioning on Perioperative Ischemia-reperfusion Injury During Intracranial Aneurysm Surgery

Conditions
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Brain Ischemia

Intervention / Treatment
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* Procedure: Sev-I group
* Procedure: Sevo continuous inhalation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient under intracranial aneurysm surgery. Exclusion Criteria: Patients who refused to participate or who had a history of chemotherapy/convulsions two weeks prior to admission, stroke/cardiopulmonary resuscitation/head trauma three months prior to admission, Alzheimer's disease, amyotrophic lateral sclerosis, and prior melanoma were excluded.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Propofol group<br>Patients will receive the total intravenous anesthesia with propofol infusion during the surgery. | |
| Active Comparator: Sevo-C group<br>Patients will receive the anesthesia with continuous inhalation of sevoflurane. | Procedure: Sevo continuous inhalation<br>* Patients will receive the anesthesia with continuous inhalation of sevoflurane.<br>|
| Experimental: Sevo-I group<br>Sevoflurane will be given before the cerebral artery clip as a preconditioning procedure for the coming ischemia-reperfusion injury. | Procedure: Sev-I group<br>* Sevoflurane will be given before the cerebral artery clip as a preconditioning procedure for the coming ischemia-reperfusion injury.<br>* Other names: Sevoflurane preconditioning;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| S-100B,NSE |  | 7 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Karnofsky Performance Scale,NIH stroke index, MMSE |  | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cerebral ischemia, sevoflurane preconditioning, intracranial aneurysm surgery