Source-monitoring & Psychosis

Study Overview
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Brief Summary
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Source-monitoring is a cognitive process that refers to the ability to remember the source of an information. Some studies have showed source-monitoring deficits in patients with schizophrenia as well as in individuals at ultra-high risk for psychosis (UHR) and in first-episode psychosis patients (FEP). Source-monitoring deficits have thus been proposed as a potential early risk factor for psychosis. However, further studies are needed to better characterize this deficit. The aim of this project is to investigate source-monitoring performances in UHR, FEP patients and healthy controls (HC) and to characterize these deficits in terms of brain anatomy, basic auditory processes and social functioning.

Detailed Description
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Ninety participants will be included in the study: 30 UHR, 30 FEP and 30 healthy controls. All the participants will complete a standardized source-monitoring task, an MRI acquisition (3D-T1 anatomical scan), a tone-matching task as well as a socio-demographic and clinical evaluation including an assessment of the social functioning.

Official Title
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Source-monitoring Processes and Risk for Psychosis

Conditions
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Psychosis

Intervention / Treatment
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* Other: Cognitive tests and neuroimaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men and Women aged between 18 and 30 Having given their written informed consent French speakers and readers Absence of hearing impairments (or tinnitus) that could prevent the successful completion of tasks involving listening to sounds or words Absence of visual impairments that could prevent the successful completion of tasks involving reading on the screen For the healthy control group, no history of previous diagnosed psychiatric disorders (according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders - DSM5), absence of relatives diagnosed with spectrum disorder schizophrenia and bipolar disorder (DSM5), absence of psychotic prodromes measured by a score of less than 6 in the prodromal questionnaire - PQ-16 (Ising et al., 2012), absence of drug treatments (except oral contraception). For the UHR group, meeting the UHR criteria according to the Comprehensive Assessment of at-risk mental state (CAARMS). For the FEP group, presenting with daily psychotic symptoms for at least a week. Exclusion Criteria: Do not consent to be included in the study Contraindication to MRI scan History of neurological disease Pregnancy Being under tutorship or curatorship Having developed musical abilities (that is, regularly practicing a musical instrument)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Three groups of participants will be recruited: individuals at ultra-high risk for psychosis, first-episode psychosis patients and healthy controls.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: individuals at ultra-high risk for psychosis (UHR)<br>30 individuals meeting the UHR criteria according to the Comprehensive Assessment of at-risk mental state (CAARMS) will be recruited and will complete cognitive task and MRI scan | Other: Cognitive tests and neuroimaging<br>* comparison of cognitive performances and brain anatomy<br>|
| Experimental: patients with first episode psychosis (FEP)<br>30 patients with first episode psychosis (FEP) will be recruited and will complete cognitive task and MRI scan | Other: Cognitive tests and neuroimaging<br>* comparison of cognitive performances and brain anatomy<br>|
| Sham Comparator: healthy controls<br>30 healthy individuals will be recruited and will complete cognitive task and MRI scan | Other: Cognitive tests and neuroimaging<br>* comparison of cognitive performances and brain anatomy<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Source-monitoring performances | Scores obtained at a source-monitoring task (Brunelin et al., 2006) | one day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Confidence in source-monitoring judgements | Confidence in source-monitoring judgements will be measured using a visual analogue scale (0-100) | one day | 
| Grey matter volume | Grey matter volume will be assessed with a structural MRI scan (3D-T1) followed by morphometry analyses. | one day | 
| Brain gyrification | Brain gyrification will be assessed with a structural MRI scan (3D-T1) followed by gyrification analyses. | one day | 
| Basic auditory performances | scores at the Tone Matching Task (Strous et al., 1995) | one day | 
| Working memory performances | scores at a working memory task (Barrouillet et al., 2004) | one day | 
| Social functioning | score at the personal and social performance scale (0-100) | one day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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source-monitoring, at-risk, MRI, neuroimaging