Gonorrhea and Chlamydia HIV-infected Men Who Have Sex With Men

Study Overview
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Brief Summary
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This study will estimate the rates of asymptomatic Chlamydia and/or Gonorrhea in the oropharynx, rectum and urethra (urine) of HIV infected men who have sex with men at a specialty care center and compare it to the rates in Douglas County, using nucleic acid amplification tests.

Detailed Description
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Hypothesis: Men who have sex with men (MSM) are at higher risk for sexually transmitted diseases. Currently, free testing for sexually transmitted diseases is only being performed in urine samples. Investigators hypothesize that the rates of both gonorrhea and chlamydia will be higher when testing includes more than one anatomical site (rectum and oropharynx). The aim of the study is to estimate the rates of asymptomatic Chlamydia and/or Gonorrhea in the oropharynx, rectum and urethra (urine) of HIV infected men who have sex with men at the specialty care center of the University of Nebraska Medical Center and compare to the rates in Douglas County, using nucleic acid amplification tests.

Official Title
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Prevalence of Gonorrhea and Chlamydia Infections in Multiple Anatomical Sites in HIV-infected Men Who Have Sex With Men at an HIV Clinic in Omaha, Nebraska

Conditions
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HIV Infection, Chlamydia, Gonorrhea

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: HIV infection Men with history of sex with men (including transgender and bisexual) Older than 19 years of age Asymptomatic at the time of visit. Exclusion Criteria: Active sexually transmitted disease symptoms in the oropharynx. Recent treatment for Chlamydia or gonorrhea within 3 weeks. Treatment with antibiotics active for Chlamydia or gonorrhea within the last 2 weeks: doxycycline, quinolones and azithromycin, and cefixime. Women. Inability to complete the questionnaire in English or Spanish.

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Chlamydia or gonorrhea infection | Investigators will use nucleic acid amplification tests in urine, rectal and oropharyngeal swab specimens to detect asymptomatic chlamydia and/or gonorrhea infection | one day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| accuracy for detecting infection when using one versus 2 versus 3 anatomical sites | Investigators will compare the proportion of infections detected by using only urine, only rectum, only oropharynx vs. using combined sites (urine and rectum, urine and oropharynx or oropharynx and rectum) vs. using all 3 sites. | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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HIV Infection, Men who have sex with men, Chlamydia, Gonorrhea