Bioimpedance Analysis Guided Volume Expansion for the Prevention of Contrast Induced-acute Kidney Injury

Study Overview
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Brief Summary
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Bioelectrical impedance analysis guided volume expansion for the prevention of contrast induced-acute kidney injury

Detailed Description
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Compared bioelectrical impedance analysis guided hydration therapy versus standard hydration for the prevention of contrast induced-acute kidney injury

Official Title
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Bioimpedance Analysis Guided Volume Expansion for the Prevention of Contrast

Conditions
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X-ray Contrast Media Adverse Reaction

Intervention / Treatment
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* Other: Bioimpedance guided
* Other: standard hydration


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18-90 yr Chronic kidney disease stage 3 & 4 (eGFR 15-60 ml/min/m2) elective cardiac catheterization Exclusion Criteria: Contrast media administration in the past 14 days congestive heart failure (NYHA III-IV, ascites , pleuropericardial effusion ,severe valvular heart disease Kidney transplant status or RRT Emergency cardiac catheterization Allergy to radiographic contrast media Unstable renal function (change in serum creatinine ≥ 0.5 mg/dl or 25% within 14 days prior to the study Not inform consent left ventricular ejection fraction < 40 % Liver cirrhosis child B or C Dosage of angiotensin-converting enzyme inhibitor /angiotensin II receptor blocker changed in past 2 wk

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Control<br>standard hydration : 7.5% Sodium bicarbonate 150 ml + 5% dextrose in water 850 ml IV 1 ml/kg/hr in 6 hours | Other: standard hydration<br>* standard hydration : 7.5%Sodium bicarbonate 150 ml + 5% dextrose in water 850 ml IV 1 ml/kg/hr in 6 hours<br>|
| Experimental: Bioimpedance guided<br>Bioelectrical impedance analysis guided hydration therapy : 7.5% Sodium bicarbonate 150 ml + 5% dextrose in water 850 ml IV in 6 hours rate was adjusted regarding to extracellular water/total body water extracellular water/total body water < 0.36 : 4 ml/kg/hr extracellular water/total body water 0.36-0.4 : 2 ml/kg/hr extracellular water/total body water > 0.4 : 1 ml/kg/hr | Other: Bioimpedance guided<br>* bioelectrical impedance analysis guided hydration therapy : 7.5% Sodium bicarbonate 150 ml + 5% dextrose in water 850 ml IV in 6 hours rate was adjusted regarding to extracellular water/total body water extracellular water/total body water < 0.36 : 4 ml/kg/hr extracellular water/total body water 0.36-0.4 : 2 ml/kg/hr extracellular water/total body water > 0.4 : 1 ml/kg/hr<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| serum creatinine at 48-72 hours after contrast administration | Acute kidney injury | 48-72 hr | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| serum creatinine at 2 weeks after contrast administration | Renal replacement therapy | 2 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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contrast induced acute kidney injury, bioimpedance