Comparison of the Bilateral TAP Block Versus Curare in Muscle Relaxation of the Abdominal Wall During Laparoscopic Digestive Surgery: Prospective Randomized Study

Study Overview
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Brief Summary
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This is a Biomedical Research, prospective, randomized, controlled single-blind mono centric, phase IV comparison trial of the bilateral TAP block versus curare in muscle relaxation of the abdominal wall during laparoscopic digestive surgery.

Official Title
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Comparison of the Bilateral Transversus Abdominis Plane (TAP) Block Versus Curare in Muscle Relaxation of the Abdominal Wall During Laparoscopic Digestive Surgery: Prospective Randomized Study

Conditions
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The Main of This Study is to Compare the Nerve Block of the Muscles of the Abdominal Wall Between the Bilateral TAP Block and Curare

Intervention / Treatment
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* Drug: Transversus Abdominis Plane
* Drug: Curare


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients older than 18 years and under 75 years Informed consent signed ASA I, II and III Patient affiliated to social security Exclusion Criteria: ASA IV BMI> 35 kg / m Personal or family history of malignant hyperthermia History of allergy or hypersensitivity to intravenous anesthetics (remifentanil), local anesthetics or muscle relaxants Contraindications to sevoflurane: a history of malignant hyperthermia, history of liver disease after sevoflurane anesthesia, halogenated agents or hypersensitivity to any of these components. Contraindications to succinylcholine: hyperkalemia, plasma cholinesterase deficiency nickname, para or tetraplegia more than 24 hours, burns over 24 Contraindications to cisatracurium: myasthenia Neuromuscular diseases Contraindications to local anesthetics: hypersensitivity to local anesthetics of the amide, intravenous regional anesthesia, porphyria, ventricular atrial conduction disturbances, epilepsy uncontrolled by treatment Pregnancy and lactation severe coagulation disorders Inability to understand and give informed consent Patient under guardianship, curatorship or protected Indication of use of a hypnotic ketamine (BIS change)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: TAP<br> | Drug: Transversus Abdominis Plane<br>* PIA coelioscopic<br>|
| Active Comparator: curare<br>Patients will be randomized into two parallel groups. One group will receive curare, another benefit of a bilateral TAP block | Drug: Curare<br>* IAP coelioscopic<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle relaxation. | Muscle relaxation of the abdominal wall will be evaluated based on the amount of volume infused initially to create the pneumoperitoneum. This parameter is given by the unit of laparoscopy and allow us to calculate the abdominal compliance (C = ΔV / Ap). | 20 minutes after anesthesia induction |