The Use of Lung Ultrasonography in COVID-19 Patients

Study Overview
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Brief Summary
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In COVID-19 patients hospitalized in the intensive care unit due to respiratory failure, lung ultrasonography will be tried to be given an appropriate position that will effectively use lung capacity and its effect on oxygenation will be investigated.

Detailed Description
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In this study, the COVID-19 patients hospitalized in the intensive care unit due to respiratory failure will be evaluated. Participants will be divided into two groups as patients undergoing lung ultrasonography (Group Ultrasonography ) and those without lung ultrasonography (Group Control). While performing lung ultrasonography, each hemithorax will be evaluated using anterior axillary line and posterior axillary line into anterior, lateral and posterior region, and each region will be divided into 6 quadrants, upper and lower. Each hemithorax will be scanned by the investigators, scored in 6 regions using a convex ultrasonography probe with the Lung Ultrasound Score (LUS score). Participants in both groups will be evaluated by comparing arterial blood gas analyzes before examination (with/without ultrasonography), at the 2nd and 12th hours. Is there any change in arterial blood gas values such as PO2 and PCO2 at 0, 2 and 12 hours so that oxygenation and ventilation between Group Ultrasonograpy and Group Control will be evaluated?

Official Title
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The Significance of Lung Ultrasonography in the Follow-up and Treatment of COVID-19 Patients With Respiratory Failure

Conditions
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Ultrasonography

Intervention / Treatment
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* Behavioral: mechanical ventilator settings and position


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients have been diagnosed with COVID 19 Patients in the intensive care unit over the age of 18 Exclusion Criteria: Patients not diagnosed with COVID 19 Patients with cardiac problems Patients with renal problems

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: patients will be divided into two groups, those with and without ultrasound.
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: GRUP Control<br>The daily respiratory system examination of COVID-19 patients who are hospitalized in the intensive care unit is performed and the necessary mechanical ventilation applications are performed by evaluating the arterial blood gas analysis. | Behavioral: mechanical ventilator settings and position<br>* Mechanical ventilation settings and patient position will be re-evaluated<br>|
| Active Comparator: GRUP Ultrasonography<br>The daily respiratory system examination of COVID-19 patients who are hospitalized in the intensive care unit is performed and the necessary mechanical ventilation applications are performed by evaluating the arterial blood gas analysis. However, the lung of the patient will be evaluated by ultrasound and the position to use the lung capacity most appropriately will be given. | Behavioral: mechanical ventilator settings and position<br>* Mechanical ventilation settings and patient position will be re-evaluated<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in PO2 values | Effect of positioning on ultrasound guidance on oxygenation assessed by changes between pO2 values. | 12 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in PCO2 values | Effect of positioning on ultrasound guidance on ventilation assessed by changes between pCO2 values. | 12 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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lung ultrasonography, intensive care unit, position, COVID-19