Exercise Training in Patients With Chagasic Heart Disease Without Ventricular Dysfunction

Study Overview
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Brief Summary
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The prevalence of Chagas' disease continues high even in the developed countries. Chagasic Cardiomyopathy with preserved ventricular function is an understudied form of Chagas disease. Since a majority of patients with these changes progress to dilated form with ventricular dysfunction with all its serious consequences, it is interesting to better understand the pathophysiology of the disease at the stage where there electrocardiographic changes and preserved ventricular function. And besides, search strategies to slow the progress, or even prevent the chronic phase of the disease. For this reason the investigators will evaluate the effects of exercise training in patients with Chagas cardiomyopathy without ventricular dysfunction.

Detailed Description
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Chagasic Cardiomyopathy with preserved ventricular function is an understudied form of Chagas disease. Since a majority of patients with these changes progress to dilated form with ventricular dysfunction with all its serious consequences, it is interesting to better understand the pathophysiology of the disease at the stage where there electrocardiographic changes and preserved ventricular function. And besides, search strategies to slow the progress, or even prevent the chronic phase of the disease. For this reason the investigators will evaluate the effects of exercise training in patients with Chagas cardiomyopathy without ventricular dysfunction.

Official Title
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Effects of Physical Training on Sensitivity Baroreflex Patients Without Chagas' Heart Ventricular Systolic Dysfunction

Conditions
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Chagas Disease

Intervention / Treatment
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* Other: Exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Chagas' disease patients, diagnosed with at least two positive serological reactions to Chagas' disease, Ejection fraction ≥55% Exclusion Criteria: Participation in a regular exercise program in the last 3 months preceding the survey Use of oral anticoagulant Use of a pacemaker or implantable cardioverter Hemodynamic instability Myocardial revascularization infarction or unstable angina in the last 3 months of the start of the protocol Diabetes mellitus Hypertension Pulmonary Disease Valvular lesions Atrial Fibrillation Angina of effort

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Sedentary Group<br>The patients will not do exercise training | |
| Experimental: Trained Group<br>The patients will do exercise training for sixteen weeks. | Other: Exercise<br>* Exercise Training for 4 months<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sympathetic nerve activityAutonomic control | Exercise training will improve baroreflex sensitivity and reduce sympathetic nerve activity. | 4 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Peak oxygen consumption | Exercise training will improve peak oxygen consumption | 4 months | 
| Skeletal muscle strength | Exercise training will increase skeletal muscle strength | 4 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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chagas disease, exercise, baroreflex sensitivity