Parkinson's Disease, Diagnostic Observations (PADDO)

Study Overview
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Brief Summary
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Background: Parkinson's Disease and the Atypical Parkinsonian Disorder (like Multiple System Atrophy, Progressive Supranuclear Palsy, Corticobasal Degeneration, Lewy Body Dementia) are disease entities with partly common symptomatology. Especially very early in the course of disease, the differentiation between both disease entities can be challenging, even for specialists in the field of movement disorder. However, the establishment of a correct diagnosis is very important for adequate patientcounseling, treatment and the correct inclusion of patients in research trials. Ancillary diagnostic investigations are looked upon to aid in this diagnostic dilemma. Objective: To investigate the value of ancillary diagnostic investigations, more specific MRI, analysis of cerebrospinal fluids and a second opinion in a specialized movement disorder centre, to differentiate Parkinson's disease and the Atypical Parkisonisonian disorder.

Official Title
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Observational Study Assessing the Diagnostic Contribution of 3-Tesla MRI, CSF Analysis and a Second Opinion in a Specialized Movement Disorder Centre, in Differentiating Between Parkinson's Disease and Atypical Parkinsonism

Conditions
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Parkinson's Disease, Atypical Parkinsonism

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Hypokinetic rigid syndrome Disease duration of maximum 36 months Exclusion Criteria: Probable diagnosis of PD without any red flags Probable diagnosis MSA Probable diagnosis PSP Diagnosis CBD Diagnosis DLB Probable diagnosis Vascular Parkinsonism Other neurodegenerative disease than parkinsonism A prior history of brain surgery Instable comorbidity

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cohort<br>The cohort will consist of 150 patients with a hypokinetic rigid syndrome and a disease duration of maximum 36 months | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| percentage of correct diagnosis for each of the specified ancillary investigations | Percentage of correct diagnosis for each of the specified ancillary investigations to differentiate between either PD or atypical parkinsonism | 36 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of correct diagnosis for each of the specified ancillary investigations | Percentage of correct diagnosis for each of the specified ancillary investigations(MRI, CSF analysis, and second opinion) to differentiate between the specific diagnosis (PD, MSA, PSP, CBD, LBD, VaP) | 36 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Prospective study, diagnostic accuracy, CSF, MRI