Evaluation of Effect of Different Ventilator Mods on Atelectasis in Patients Undergoing Laparoscopic Surgery

Study Overview
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Brief Summary
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In this study researchers aim to evaluate effect of different ventilation modalities on the developments of atelectasis by using ultrasound.

Detailed Description
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Patients undergoing laparoscopic surgery will be randomly assigned either volume controlled ventilation group or pressure controlled volume guaranteed ventilation group. All patients will be performed lung ultrasonography pre and postoperatively to evaluate the development of lung atelectasis and effect of different ventilation modalities on the development of atelectasis.

Official Title
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Evaluation of Effect of Different Ventilator Mods on Atelectasis in Patients Undergoing Laparoscopic Surgery: a Prospective Randomized Controlled Clinical Trial

Conditions
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Atelectasis, Atelectases, Postoperative Pulmonary

Intervention / Treatment
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* Procedure: VCV
* Procedure: PCV-VG
* Diagnostic Test: lung ultrasonography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: undergoing laparoscopic surgery ASA Status I-II Exclusion Criteria: Gastroesophageal reflux obstructive sleep apnea syndrome BMI>30 severe lung and heart disease ASA Status III-IV

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: VCV-Lung Ultrasonography<br>patients undergoing laparoscopic surgery will be performed pre and postoperatively lung ultrasonography. after induction of anesthesia patients will be supported by mechanical ventilation on volume controlled ventilation mode. | Procedure: VCV<br>* after induction for anesthesia patients will be supported by mechanical ventilation on volume controlled ventilation mode<br>Diagnostic Test: lung ultrasonography<br>* all patients will be performed lung ultrasonography pre and postoperatively<br>|
| Active Comparator: PCV-VG- Lung Ultrasonography<br>patients undergoing laparoscopic surgery will be performed pre and postoperatively lung ultrasonography.after induction of anesthesia patients will be supported by mechanical ventilation on pressure controlled volume guaranteed mode | Procedure: PCV-VG<br>* after induction for anesthesia patients will be supported by mechanical ventilation on pressure controlled and volume guaranteed ventilation mode<br>Diagnostic Test: lung ultrasonography<br>* all patients will be performed lung ultrasonography pre and postoperatively<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect of different ventilation mods on development of peroperative atelectasis | Patients undergoing laparoscopic surgery will be assigned either volume controlled mode or pressure support volume guaranteed mode. After the operation a researcher will perform lung ultrasonography postoperative at minute 5. Researcher will detect 6 region of each lung totally 12 regions . The researcher will record the modified and original lung ultrasonography scores (LUS Score) of the patients. LUS Score is a scoring system to evaluate atelectasis of lung and scores 1-3 points for each region (Min score 0 max score 36) | at minute 5 in postoperative care unit | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect of different ventilation mods on development of peroperative atelectasis | Patients undergoing laparoscopic surgery will be assigned either volume controlled mode or pressure support volume guaranteed mode. After the operation a researcher will perform lung ultrasonography in postoperative care unit at minute 30. Researcher will detect 6 region of each lung totally 12 regions . The researcher will record the modified and original lung ultrasonography scores (LUS Score) of the patients. LUS Score is a scoring system to evaluate atelectasis of lung and scores 1-3 points for each region.(Min score 0 max score 36) | at minute 30 in postoperative care unit | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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postoperative atelectasis, mechanical ventilation, laparoscopic surgery, lung ultrasonography, volume controlled ventilation, pressure controlled