Évaluation de l'Impact du Compressed Sensing Sur le Signal QSM

Study Overview
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Brief Summary
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Patients who have agreed to participate in the study will complete the MRI protocol as part of routine care, to which a maximum of four additional 25-minute sequences will be added. MRI of routine care includes at least the following sequences: 3D T1 TFE (2 minutes) T2 TSE (2 minutes) 3D FLAIR (3 minutes) The sequences added by the research lasting 25 minutes are: SWI QSM 1.0iso 8 echoes (10 minutes) SWI QSM 1.0iso 8 echoes CS 6 (7 minutes) SWI QSM 1.0iso 8 echoes CS 9 (5 minutes) SWI QSM 1.0iso 8 echoes CS 12 (3 minutes)

Detailed Description
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Patients who have agreed to participate in the study will complete the MRI protocol as part of routine care, to which a maximum of four additional 25-minute sequences will be added. MRI of routine care includes at least the following sequences: 3D T1 TFE (2 minutes) T2 TSE (2 minutes) 3D FLAIR (3 minutes) The sequences added by the research lasting 25 minutes are: SWI QSM 1.0iso 8 echoes (10 minutes) SWI QSM 1.0iso 8 echoes CS 6 (7 minutes) SWI QSM 1.0iso 8 echoes CS 9 (5 minutes) SWI QSM 1.0iso 8 echoes CS 12 (3 minutes)

Official Title
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Évaluation de l'Impact du Compressed Sensing Sur le Signal QSM

Conditions
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MRI

Intervention / Treatment
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* Device: MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: For patients with MS: Patient over 18 years old Presenting MS defined according to McDonald's revised criteria for spatial and temporal clinical or radiological dissemination [16], Should benefit as part of the care of an MRI examination with or without injection of gadolinium Express consent to participate in the study Affiliate or beneficiary of a social security scheme For patients with an indication to undergo a brain MRI and at low risk of inflammatory CNS disease: Patient over 18 years old Should benefit as part of the care of an MRI examination with or without injection of gadolinium Express consent to participate in the study Affiliate or beneficiary of a social security scheme Exclusion Criteria: For patients with MS: Patient benefiting from a legal protection measure Pregnant or breastfeeding woman For patients with an indication to undergo a brain MRI and at low risk of inflammatory CNS disease: Patient benefiting from a legal protection measure Pregnant or breastfeeding woman Patient with inflammatory and / or demyelinating pathology of the CNS Secondary exclusion criteria : Motion artefact not allowing interpretation of images Patient who did not perform one of the following sequences: 3D T1 TFE, 3D FLAIR (for MS patients), SWI QSM 1.0iso 8 echoes. Secondarily excluded patients will be replaced.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| SEP<br>With Multiple Sclerosis as defined by McDonald's revised clinical or radiological spatial and temporal dissemination criteria | Device: MRI<br>* MRI of routine care includes at least the following sequences: 3D T1 TFE (2 minutes) T2 TSE (2 minutes) 3D FLAIR (3 minutes) The sequences added by the research lasting 25 minutes are: SWI QSM 1.0iso 8 echoes (10 minutes) SWI QSM 1.0iso 8 echoes CS 6 (7 minutes) SWI QSM 1.0iso 8 echoes CS 9 (5 minutes) SWI QSM 1.0iso 8 echoes CS 12 (3 minutes)<br>|
| NO SEP<br>For patients with an indication to undergo a brain MRI and at low risk of inflammatory CNS disease | Device: MRI<br>* MRI of routine care includes at least the following sequences: 3D T1 TFE (2 minutes) T2 TSE (2 minutes) 3D FLAIR (3 minutes) The sequences added by the research lasting 25 minutes are: SWI QSM 1.0iso 8 echoes (10 minutes) SWI QSM 1.0iso 8 echoes CS 6 (7 minutes) SWI QSM 1.0iso 8 echoes CS 9 (5 minutes) SWI QSM 1.0iso 8 echoes CS 12 (3 minutes)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| concordance of QSM signal with and without compressed-sensing in white matter | concordance of QSM signal with and without compressed-sensing in white matter | 1 DAY |