Low Level Laser Intervention for Individuals With Knee Osteoarthritis

Study Overview
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Brief Summary
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The purpose of this study was to investigate the intervention effects of low level laser for knee OA group

Official Title
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The Effects of Low Level Laser Intervention on Muscular Strength for Individuals With Knee Osteoarthritis

Conditions
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Osteoarthritis, Knee

Intervention / Treatment
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* Device: Low level laser treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The severity of osteoarthritis was defined by the Kellgren-Lawrence system as grade 2 - grade 3 Exclusion Criteria: Uncontrolled hypertension Malignant tumor Skin cancer Pregnant Dysesthesia Pacemaker inplement Cognitive problem Fall record within 6 months Dysfunction of blood coagulation

Ages Eligible for Study
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Minimum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 808nm<br>The wavelength of this experimental group was 808nm, total power: 3.6W, 15 minutes a session, 3 times a week for 8 weeks | Device: Low level laser treatment<br>* The intervention protocol includes 2 wavelength as the experimental group, each of the were 808nm, 660nm, and 1 placebo intervention which output total power is only 0.0072W.<br>|
| Active Comparator: 660nm<br>The wavelength of this experimental group was 660nm, total power: 3.6W, 15 minutes a session, 3 times a week for 8 weeks | Device: Low level laser treatment<br>* The intervention protocol includes 2 wavelength as the experimental group, each of the were 808nm, 660nm, and 1 placebo intervention which output total power is only 0.0072W.<br>|
| Placebo Comparator: Control<br>The wavelength of control group, total power: 0.0072W, 15 minutes a session, 3 times a week for 8 weeks | Device: Low level laser treatment<br>* The intervention protocol includes 2 wavelength as the experimental group, each of the were 808nm, 660nm, and 1 placebo intervention which output total power is only 0.0072W.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of muscular strength of thigh measured by handheld dynamometer | Muscular strength of the knee extensor and flexor on both sides and will be normalized by the body weight of participants' (lb/kg) | Baseline and after treatment, 8 weeks intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of walking speed measured by the stop watch | 40-m walk test, participants are instructed to walk as fast as they could, investigator records the time they spend. (seconds) | Baseline and after treatment, 8 weeks intervention | 
| Changes of stair climbing ability measured by the stop watch | stair climbing test, participants are instructed to climb stairs with a total height of 180 cm as fast as they could, investigator records the time they spend. (seconds) | Baseline and after treatment, 8 weeks intervention | 
| Changes of chair stand ability, the stop watch will be used to measure time and investigators count the time that participants complete | sit-to-stand test, participants are instructed to repeat chair stand movement as fast as they could, investigator records the times they complete. (times) | Baseline and after treatment, 8 weeks intervention | 
| Changes of dynamic balance ability measured by the stop watch | timed UP&Go test, participants are instructed to stand up from a chair and walk as fast as they could for 3 meters and back to the chair, investigator records the time they spend. (seconds) | Baseline and after treatment, 8 weeks intervention |