Does Vestibular Rehabilitation Significantly Improve the Level of Vestibular Function Following Vestibular Neuritis?

Study Overview
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Brief Summary
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To investigate which treatment option (corticosteroid treatment alone or combined corticosteroid treatment and vestibular rehabilitation) is the most effective in patients diagnosed with vestibular neuritis.

Detailed Description
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Patients diagnosed with vestibular neuritis will we consider for enrollment. Each patient will undergo randomization for a specific treatment.

Official Title
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Which Treatment is Most Effective When Treating Vestibular Neuritis: Corticosteroid Treatment Alone or Combined Corticosteroid Treatment and Vestibular Rehabilitation?

Conditions
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Vestibular Neuritis

Intervention / Treatment
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* Other: Vestibular rehabilitation
* Drug: Corticosteroid


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age above 18 years of age Medical history compatible with vestibular neuritis Verification of vestibular neuritis with positive romberg test, pathological v-HIT and horizontal nystagmus with a rotatory component. Exclusion Criteria: Former medical history with vestibular dysfunction Medical history or objective signs of cochlear dysfunction before, during or after onset of vestibular neuritis Onset of symptoms 14 days before recruitment to the study Focal neurological symptoms/signs Contraindication to prednisolone treatment Problem with participating in vestibular rehabilitation due to muscular-skeletal disease ect.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Patients randomized to two different treatments: corticosteroid treatment (prednisolone) combined corticosteroid treatment (prednisolone) and vestibular rehabilitation
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Neuritis vestibularis (group 1)<br>Corticosteroid (prednisolone) | Drug: Corticosteroid<br>* Prednisolone<br>|
| Experimental: Neuritis vestibularis (group 2)<br>Corticosteroid (prednisolone) + vestibular rehabilitation | Other: Vestibular rehabilitation<br>* Specialized physical therapy aimed at restoring balance<br>Drug: Corticosteroid<br>* Prednisolone<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Suppressing head impulse paradigm (SHIMP) | SHIMP equipment will objectively quantify change of vestibular function. | 6 month | 
| Subjective visual vertical (SVV) | SVV test will objectively quantify the experienced spatial orientation as an indicator of visual and vestibular otolithic function | 6 month | 
| Video head impulse test (v-HIT) | v-HIT equipment will objectively quantify change of vestibular function. | 6 month | 
| Dizziness handicap inventory (DHI) questionnaire | Fulfillment of the questionnaire Dizziness Handicap Inventory (DHI) will quantify the level of experienced vertigo. | 6 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Vestibular Neuritis, SHIMP (suppressing head impulse paradigm), SVV (subjective visual vertical), Vestibular rehabilitation, Prednisolone, v-HIT (video head impulse test), Vestibular Neuronitis