Objective, Passive Assessment of LRRK2 Carriers

Study Overview
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Brief Summary
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The goal of this project is to identify objective, sensitive, and convenient measures for assessing early signs of Parkinson's disease in an at-risk population at home. We will do so by using a wireless sensor and analyzing the radio signals that bounce off patients' bodies, while patients go about their normal life without needing to wear sensors, answer questionnaires, or actively perform any tests.

Official Title
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Objective, Passive Assessment of LRRK2 Carriers

Conditions
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Parkinson Disease

Intervention / Treatment
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* Device: Emerald device


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: At least 50 years of age Able and willing to provide informed consent English fluency U.S. resident LRRK2 G2019S gene carrier, determined by participation in VALOR-PD Mild parkinsonian signs, determined by modified Movement Disorder Society-Unifeid Parkinson's Disease Rating Scale (MDS-UPDRS) score from the most recent VALOR-PD visit Have WiFi in their residence Access to a smartphone or tablet Exclusion Criteria: Inability to complete study activities, as determined by the study team Any medical or psychiatric condition that, in the study team's judgement, would preclude participation Self-reported or VALOR-PD investigator determined Parkinson's disease Any movement disorder (e.g. essential tremor) Currently taking neuroleptics or other drugs known to cause parkinsonism Pregnancy Non-ambulatory status More than one ambulatory pet in the household* More than two individuals in the household (not including participant)* these criteria can be waived at the discretion of the investigators

Ages Eligible for Study
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Minimum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Emerald device|The Emerald device is a wireless sensor that can track the motion, breathing, and sleep of participants without touching or requiring any interaction with the participants, allowing them to go about their normal lives. The Emerald device operates by transmitting and receiving low power radio signals that reflect off of the participant and return back to the device. The power of these signals is 1,000 times lower than what a typical Wi-Fi device transmits. The ability of the device to monitor gait, breathing, sleep, and other metrics has been validated and documented. Studies of the Emerald device in individuals with Parkinson's disease, Alzheimer's disease, and rare diseases have demonstrated the feasibility of monitoring at home and the ability to characterize gait, breathing, and sleep in these populations specifically. In this study, the Emerald device will be used to characterize the mobility, breathing and sleep of the participant.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gait speed |  | 1 year |