linjc16/ctgov huggingface dataset:
Emergency Room Evaluation and Recommendations for Older Users of Emergency Departments

Study Overview
=================
Brief Summary
-----------------
The study evaluates if the Emergency Room Evaluation and Recommendation Tool (ER2) reduces the hospital admission rate and the length of stay in Emergency.

Detailed Description
-----------------
Regardless of the reason for ED visit and its care plan, there are simple interventions, which may be continued to prevent short-term ED adverse outcomes. Delirium, motor deconditioning, adverse drug reactions due to polypharmacy, and inappropriate home support are the main conditions to target when taking care of older ER users. Evidence based medicine showed that simple and early intervention in the process of care may prevent delirium (e.g., hydration, avoid restraint, mobilize and satisfy basic needs, time and place reorientation) and motor deconditioning (e.g., encourage mobility, up to chair at meal time during day light hours, provide appropriate walking aid) in older patients. The medication reconciliation is also an efficient intervention for the prevention of adverse drug reactions. Furthermore, an early assessment of home support is a crucial step to adjust home services for an early discharge to home.

Official Title
-----------------
Emergency Room Evaluation and Recommendations for Older Users of Emergency Departments: a Cohort Study Database on the Effects of ER2 Recommendations on Length of Stay and Hospital Admission

Conditions
-----------------
Elderly Care, Length of Hospital Stay, Multimorbidity

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Being 75 years old and over Being brought at Emergency on medical stretcher Exclusion Criteria: Being less than 75 years old Never come at Emergency

Ages Eligible for Study
-----------------
Minimum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Observational<br>At Emergency nurses will carry out a test called: Emergency Room Evaluation and Recommendation which contents the following statements: Being 85 years older and over (Yes/No) Male (Yes/No) Home services (Yes/No) Taking 5 different medication daily (Yes/No) Use of walking aid (Yes/No) Disoriented (Yes/No) | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hospital admission rate by age | The recommendation of the Emergency Room Evaluation Tool will be used to reduce the hospital admission rate in older at Emergency. | Around 10 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of stay at Emergency | The recommendation of the Emergency Room Evaluation Tool will be used to reduce the length of stay at Emergency. | Around 10 months |
Preventive Approach for the Management of the Main Geriatric Risks

Study Overview
=================
Brief Summary
-----------------
Nowadays, EHPAD residents are polypathological (cognitive and psycho-behavioral pathologies, undernutrition, IC, diabetes, COPD, IR, etc.) and multi-medicated. From a medical point of view, this implies the need for regular monitoring and a high level of medical or even multidisciplinary expertise for the healthcare team. The objective of the GER-e-TEC ™ project is to provide these complex patients with telemedicine tools allowing protocolized and personalized, non-intrusive monitoring. The GER-e-TEC ™ project more specifically takes into account the significant issues in nursing homes of aging residents with the main geriatric syndromes (fall, undernutrition, cognitive-behavioral disorders, iatropathogeny, etc.) The objective of the work undertaken is to develop a codified preventive approach for the management of the main geriatric risks, in order to avoid the occurrence of an acute decompensation factor in the elderly.

Official Title
-----------------
Development of a Codified Preventive Approach for the Management of the Main Geriatric Risks

Conditions
-----------------
Geriatric Syndromes

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Major subject (≥65 years old) Subject hospitalized between June 17, 2019 to November 13, 2019, in the UF 3723 department, of the Medical Clinic B of the University Hospitals of Strasbourg Having not expressed his opposition, after information, to the reuse of his data for the purposes of this research. Exclusion criteria: Subject having expressed opposition to participating in the study Impossibility of providing the subject with enlightened information (difficulties in understanding the subject, etc.) Subject under guardianship or guardianship Subject under safeguard of justice Subject in palliative / end of life situation Subject in acute emergency situation

Ages Eligible for Study
-----------------
Minimum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Retrospective study of the management of the main geriatric risks in the University HÔptaux de Strasbourg |  | Files analysed retrospectively from from June 17, 2019 to November 13, 2019 will be examined] | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
undernutrition,, Geriatric syndromes, psycho-behavioral pathologies, diabetes
Anterior Lingual Frenectomy is Inadequate in Improving Breastfeeding Outcomes: a Prospective Cohort Study

Study Overview
=================
Brief Summary
-----------------
A previously published study (https://www.ncbi.nlm.nih.gov/pubmed/27641715) identified breastfeeding improvements following lingual frenotomy and/or maxillary labial frenectomy. In the previous cohort, babies were excluded from the study if they had previously undergone an attempted frenotomy prior to seeing the P.I. in the office. The proposed study will only look at those babies who did undergo a previous frenotomy to determine: the presence of continued problematic breastfeeding symptoms if further tongue tie or lip tie release improves those outcomes

Official Title
-----------------
Anterior Lingual Frenectomy is Inadequate in Improving Breastfeeding Outcomes: a Prospective Cohort Study

Conditions
-----------------
Ankyloglossia, Breastfeeding

Intervention / Treatment
-----------------
* Procedure: Lingual frenotomy and/or maxillary labial frenectomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy babies who are breastfeeding Had a previous frenotomy prior to presenting to the P.I. Exclusion Criteria: Twins, triplets Maternal breast surgery or IGT Premature birth Significant heart/lung/brain disease of infant

Ages Eligible for Study
-----------------
Minimum Age: 1 Day
Maximum Age: 8 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention<br> | Procedure: Lingual frenotomy and/or maxillary labial frenectomy<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nipple pain |  | 1 week post-procedure | 
| Reflux (i-GERQ-R) |  | 1 week and 1 month post-procedure | 
| Maternal breastfeeding self-efficacy (BSES-SF) |  | 1 week and 1 month post-procedure | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
ankyloglossia, breastfeeding, lip tie
Pioglitazone vs. Insulin Glargine in the Treatment of Secondary Drug Failure in Type 2 Diabetes

Study Overview
=================
Brief Summary
-----------------
Pioglitazone and insulin glargine are equally effective in achieving glycemic control in secondary drug failure of type 2 diabetes but the mechanisms of actions are different.

Detailed Description
-----------------
The present study was undertaken to assess differences in how insulin glargine vs. pioglitazone affect: Beta-cell function as measured by proinsulin/insulin, homeostasis model assessment for insulin secretion (HOMA β-cell) and glucagon stimulated C-peptide test Insulin sensitivity as measured by adiponectin, homeostasis model assessment for insulin resistance (HOMA-IR) and insulin tolerance test and Surrogate markers of cardiovascular disease as measured by BNP, NT-pro BNP and plasma lipid profile as add-on therapy in patients with T2D and secondary drug failure. The patients' satisfaction with each treatment was also surveyed.

Official Title
-----------------
Differences in Metabolic and Cardiovascular Effects of Pioglitazone vs. Insulin Glargine in the Treatment of Secondary Drug Failure in Type 2 Diabetes

Conditions
-----------------
Type 2 Diabetes, Secondary Drug Failure

Intervention / Treatment
-----------------
* Drug: pioglitazone
* Drug: insulin glargine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: type 2 diabetes inadequately controlled on 50% of maximal-dose of an insulin secretagogue and metformin Exclusion Criteria: heart failure (NYHA II-IV)

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1<br>Pioglitazone | Drug: pioglitazone<br>* tablet, 30 mg, once daily, 26 weeks<br>* Other names: Actos;|
| Active Comparator: 2<br>Insulin glargine | Drug: insulin glargine<br>* subcutaneous injection, start dose 6-10 units, once daily, 26 weeks<br>* Other names: Lantus;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect of pioglitazone vs. insulin glargine on beta-cell function and insulin sensitivity |  | 26 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect of pioglitazone vs. insulin glargine on BNP |  | 26 weeks |
Determining the Utility of a Behavioral Intervention in Chronic Migraine

Study Overview
=================
Brief Summary
-----------------
This proposal will involve a pilot study to evaluate the feasibility, acceptability, and outcomes of a lifestyle behavior protocol in managing chronic migraine. Additionally, the proposal will investigate biomolecules that are uniquely involved in chronic migraine patients who respond to the protocol. Successful completion of this proposal will inform the design of a future full-scale behavioral clinical trial to control chronic migraine.

Official Title
-----------------
Feasibility, Acceptability, and Pilot Testing of a Behavioral Intervention for Chronic Migraine

Conditions
-----------------
Migraine, Headache, Migraine Disorders, Chronic Migraine, Lifestyle Factors, Headache Disorders

Intervention / Treatment
-----------------
* Behavioral: Lifestyle Behavior Protocol
* Behavioral: Sham Behavior Protocol


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: have chronic migraine for a minimum of 1-year aged 18 years and older Exclusion Criteria: other headache disorders including secondary headache disorders children younger than 18 years old current pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Virtual Therapy Group<br> | Behavioral: Lifestyle Behavior Protocol<br>* Virtual training on building a skillset to improve lifestyle behavior that reduces migraine attacks<br>|
| Sham Comparator: Attention Placebo Group<br> | Behavioral: Sham Behavior Protocol<br>* Virtual training on the disease of migraine and how migraine can progress to chronic migraine.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Feasibility | Recruitment rate | 12 weeks | 
| Acceptability | Retention rate | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean change from baseline monthly migraine frequency | Change in the mean of monthly migraine frequency | 12 weeks | 
| Migraine severity | severity of migraine attacks rated from 0 to 10 | 12 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Migraine Disorders, Headache, Lifestyle
Effect of Extracorporeal Shock Wave Therapy After Arthroscopic Rotator Cuff Repair

Study Overview
=================
Brief Summary
-----------------
Although radial extracorporeal shock wave therapy (rESWT) has proven to be an effective treatment, the effectiveness of the treatment has so far been controversial. There are no studies using rESWT in rehabilitation after arthroscopic rotator cuff repair (ARCR). Therefore, in this study, there is evidence that rESWT promotes pain control and healing recovery, and through previous studies, we would like to investigate whether treatment with rESWT during the intensive rehabilitation period of patients after ARCR is more effective in controlling pain.

Official Title
-----------------
Effect of Extracorporeal Shock Wave Therapy After Arthroscopic Rotator Cuff Repair

Conditions
-----------------
Rotator Cuff Injuries, Pain, Postoperative, Tissue Adhesion

Intervention / Treatment
-----------------
* Behavioral: Radial extracorporeal shockwave therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adults over 18 years old In case of 6 weeks after receiving arthroscopic rotator cuff repair When the participants wishes to enroll in the study Exclusion Criteria: 65 years old or older If the tear area is large and augmentation is performed If there is a previous surgical history at the surgical site Osteoarthritis in the shoulder joint

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Radial extracorporeal shockwave therapy<br> | Behavioral: Radial extracorporeal shockwave therapy<br>* Radial extracorporeal shockwave therapy group include Therapeutic modality(Transcutaneous electrical nerve stimulation [TENS], Microwave thermotherapy, and Superficial heat therapy), Range of motion exercise(Continuous passive motion and Active range of motion exercise).<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| . Pain intensity | A numeric pain rating scale (NPRS) consisting of 11 points in total from 0 points (no pain) to 10 points (the most severe pain imaginable) is used. The lower the score, the less the pain. | Change from baseline pain intensity at 2 weeks |
Validation of Bispectral Index (BIS)-Monitor in 3 Groups of Newborn Children

Study Overview
=================
Brief Summary
-----------------
This study will evaluate the registration of the bispectral index and spectral edge frequency in relation to the behavioural state.

Official Title
-----------------
Validation of BIS-monitor in 3 Groups of Newborn Children

Conditions
-----------------
Behavior

Intervention / Treatment
-----------------
* Procedure: Registration of the bispectral index and spectral edge frequency


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Group 1: normal healthy term newborns Group 2: Ill term newborns without brain damage Group 3: Preterm newborns without brain damage Exclusion Criteria: Abnormal brain ultrasound Abnormal neurological examination Major congenital abnormalities Use of analgesics, sedatives, antiepileptic drugs or curarisation

Ages Eligible for Study
-----------------
Minimum Age: 1 Minute

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Normal healthy term newborn<br>Normal healthy term newborns | Procedure: Registration of the bispectral index and spectral edge frequency<br>* Registration of the bispectral index and spectral edge frequency<br>|
| Ill term newly born without brain damage<br>Ill term newly borns without brain damage | Procedure: Registration of the bispectral index and spectral edge frequency<br>* Registration of the bispectral index and spectral edge frequency<br>|
| Preterm newly born without brain damage<br>Preterm newly borns without brain damage | Procedure: Registration of the bispectral index and spectral edge frequency<br>* Registration of the bispectral index and spectral edge frequency<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Validation of the Bispectral Index(BIS)-Monitor | Validation of the Bispectral Index(BIS)-Monitor by registration of the bispectral index and spectral edge frequency in relation to behavioural state | Short after birth of the newborn |
Effect of Magnesium Sulphate on Coagulation

Study Overview
=================
Brief Summary
-----------------
Arterial and venous thrombotic events are the clinical manifestation of postoperative hypercoagulability. Altered serum magnesium may play a role in the balance of coagulation. In this study, the investigators investigated the effect of magnesium sulphate on the postoperative coagulation change in total intravenous anesthesia (TIVA).

Official Title
-----------------
Effect of Magnesium Sulphate on Postoperative Coagulation as Measured by Thromboelastography

Conditions
-----------------
Myoma

Intervention / Treatment
-----------------
* Drug: Magnesium Sulfate
* Drug: normal saline


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: ASA Ⅰ-Ⅱ patients undergoing pelviscopic gynecologic operation under general anesthesia. Exclusion Criteria: Pregnancy Previous known hematologic disorder Recent medication interfering with hemostasis Severe anemia Liver disease Cardiovascular or respiratory disease

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: group C<br>control group | Drug: normal saline<br>* Group S received the same volume of isotonic saline as same method.<br>* Other names: isotonic saline;|
| Experimental: group M<br>magnesium group | Drug: Magnesium Sulfate<br>* Group M received 50 mg/kg of magnesium sulphate on 100 ml of isotonic saline over 10 minutes during the anesthesia induction, followed by the 15 mg/kg/h by continuous infusion during the operation<br>* Other names: magnesium sulphate;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| thromboelastography (TEG) analysis | 10 minutes before the induction of anesthesia 10 minutes after the recovery from the anesthesia | twice | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hemoglobin level | 10 minutes before the induction of anesthesia 10 minutes after the recovery from the anesthesia | twice | 
| platelet count | 10 minutes before the induction of anesthesia 10 minutes after the recovery from the anesthesia | twice | 
| international normalized ratio of prothrombin time (INR-PT) | 10 minutes before the induction of anesthesia 10 minutes after the recovery from the anesthesia | twice | 
| activated partial thromboplastin time (aPTT) | 10 minutes before the induction of anesthesia 10 minutes after the recovery from the anesthesia | tiwce | 
| serum magnesium level | 10 minutes before the induction of anesthesia 10 minutes after the recovery from the anesthesia | twice |
TransIent Perivascular Inflammation of the Carotid Artery (TIPIC) Syndrome: Clinical and Radiological Follow-up

Study Overview
=================
Brief Summary
-----------------
TIPIC syndrome (previously called carotidynia) is a rare entity of unknown cause, where the patient has a temporary cervical pain associated with a suggestive inflammation around the carotid artery. Usually considered as a unique and benign episode, some patients have recurrences and the follow-up is usually short. In this study the investigators aim to evaluate patients who presented a TIPIC episode at least 3 months before, clinically and with a cervical doppler ultrasound

Official Title
-----------------
TransIent Perivascular Inflammation of the Carotid Artery (TIPIC) Syndrome: Clinical and Radiological Follow-up

Conditions
-----------------
Cervical Pain, Vasculitis

Intervention / Treatment
-----------------
* Diagnostic Test: Ultrasound exam with Doppler
* Biological: Blood samples


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Patients with at least one episode of TIPIC syndrome for more than 12 months

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Ultrasound exam with Doppler|Ultrasound exam of the neck to search a perivascular inflammation at the level of the carotid bifurcation.|
|Biological: Blood samples|blood count , CRP and viral serologies (herpes virus, chlamydia, mycoplasma),|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assess the incidence of recurrence of TIPIC syndrome after a first episode |  | 1 year |