Effect of Camel Milk on Insulin and Incretin Response

Study Overview
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Brief Summary
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To examine the differential effect of camel and cow milk on the physiological response, to a liquid mixed-meal challenge, in people with normal glucose tolerance

Detailed Description
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Camel milk is used as a traditional remedy throughout the Middle East and Indian Subcontinent for conditions such as type 2 diabetes and dyslipidemia. It is currently unclear how such an effect could be mediated in vivo and studies are limited. We performed this study as a pilot experiment to assess the effects of camel milk on Insulin, Glucose, GLP-1, C-peptide and Lipid profile.

Official Title
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The Effect of Camel Milk on Insulin and Incretin Response to a Mixed-meal Challenge in People With Normal Glucose Tolerance

Conditions
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Insulin Sensitivity, Glucose Tolerance

Intervention / Treatment
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* Dietary Supplement: Camel milk
* Dietary Supplement: Cow milk


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Normal glucose tolerance BMI < 30 kg/m2 Exclusion Criteria: Type 1 diabetes mellitus Type 2 diabetes mellitus Impaired fasting glucose or impaired glucose tolerance Lactose intolerance Weight loss / gain ≥ 5 kg in the preceding two months Use of estrogenic drugs or corticosteroids Known hypertriglyceridemia requiring treatment History of heart attack, angina or cardiovascular disorder History of malignant tumor Pregnant or lactating women Hemoglobin < 12 for any reason Recent surgery or major hemorrhage History of bariatric or metabolic surgery

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Healthy individuals (camel milk)<br> | Dietary Supplement: Camel milk<br>* Camel Milk administered 10 minutes before a mixed meal of carbohydrate and protein; 2-week washout between interventions<br>|
| Experimental: Healthy individuals (cow milk)<br> | Dietary Supplement: Cow milk<br>* Cow milk administered 10 minutes before a mixed meal of carbohydrate and protein;2-week washout between interventions<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glucose response to camel and cow milk | The difference between interventions in terms of peak of glucose | 5 months | 
| Response of glucose to camel and cow milk | The difference between interventions in terms of area under the curve | 5 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Insulin response to camel and cow milk | The difference between interventions in terms of peak | 5 months | 
| Response of insulin to camel and cow milk | The difference between interventions in terms of area under the curve | 5 months | 
| GLP-1 response to camel and cow milk | The difference between interventions in terms of peak | 5 months | 
| Response of GLP-1 to camel and cow milk | The difference between interventions in terms of area under the curve | 5 months | 
| C-peptide response to camel and cow milk | The difference between interventions in terms of peak | 5 months | 
| Response of C-peptide to camel and cow milk | The difference between interventions in terms of area under the curve | 5 months |