Neuroimaging of Patients With Severe Knee Osteoarthrosis - Evaluation of Cerebral Volumetry

Study Overview
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Brief Summary
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Due to scarce published articles about this subject, the researchers aim to study the volume measurements of the brain cortex of patients with primary severe knee osteoarthrosis and those with chronic knee pain compared to healthy and non-symptomatic volunteers, correlating the neuroimaging of cerebral volumetry with pain intensity, pain duration, knee function and pressure pain threshold.

Detailed Description
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The protocol was designed to include 31 patients in each observational arm, either patients with severe knee osteoarthrosis and chronic knee pain or healthy and non-symptomatic volunteers. The researchers performed anamnesis to collect clinical and demographic information, the intensity of pain was assessed by the self-rated Visual Analogue Scale (VAS), the pressure pain threshold was evaluated with an algometer, the knee function was assessed with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scale and the images were collected with the use of the Magnetic Resonance. Covariates, such as age, gender, Body Mass Index (BMI) and comorbidities as diabetes, cardiac diseases, pulmonary diseases, endocrine diseases and the practice of physical activities were also collected.

Official Title
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Neuroimaging of Patients With Severe Knee Osteoarthrosis - Evaluation of Cerebral Volumetry

Conditions
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Osteoarthritis, Knee

Intervention / Treatment
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* Other: Osteoarthrosis
* Other: Healthy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age above 60 years old; Both genders; Clinical diagnosis of knee osteoarthrosis; Self-rated VAS moderate to severe (VAS > 4); Pain duration longer than 3 months prior to the evaluation; Signed Informed Consent; Light physical activity practice or sedentary (healthy volunteers only). Exclusion Criteria: Presence of psychiatric disorders; Presence of fibromyalgia; Presence of rheumatologic diseases; Presence of previous knee surgery; Presence of clinical symptoms (healthy volunteers only); Presence of knee pain on the previous 6 months (healthy volunteers only); History of neoplasia.

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Osteoarthrosis group<br>Patients with primary severe knee osteoarthrosis or with chronic knee pain. | Other: Osteoarthrosis<br>* Primary severe knee osteoarthrosis and chronic knee pain.<br>|
| Healthy patients<br>Healthy patients | Other: Healthy<br>* Healthy and non-symptomatic volunteers.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cerebral Volumetry Comparison | Brain Magnetic Resonance on axial Fluid Attenuated Inversion Recovery (FLAIR) and axial volume comparison between the healthy and the Knee Osteoarthrosis Group. | Baseline at time of evaluation. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| VAS Comparison | Self rated Visual Analogue Scale for pain comparison between the healthy and the Knee Osteoarthrosis Group. | Baseline at time of evaluation. | 
| Pressure Pain Threshold Comparison | Pressure algometry on the patients' back and lower limbs for comparison between the healthy and the Knee Osteoarthrosis Group. | Baseline at time of evaluation. |