Sleep, Circadian Rhythm & Skin Health

Study Overview
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Brief Summary
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The purpose of this study is to explore the mechanisms behind how sleep quality may affect skin aging, skin integrity and skin disease.

Official Title
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Sleep, Circadian Rhythm & Skin Health

Conditions
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Healthy, Psoriasis, Eczema, Acne

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Males or females ages 18 years and above Capable of giving informed consent Adults who are either healthy, normal volunteers or those with a skin disease including but not limited to eczema, psoriasis, acne or other inflammatory dermatoses Fitzpatrick Skin Type I-VI In good general health Willing to cooperate with study instructions Exclusion Criteria: Volunteers 18 years or younger Any serious medical or physical condition that would cause the subject significant discomfort with study procedures Women who are pregnant, nursing, or who may become pregnant in the next 3 months

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Normal, healthy volunteers<br>Normal, healthy volunteers without any skin pathology will be asked to undergo various procedures to evaluate their sleep and skin health. | |
| Volunteers with skin pathology<br>Volunteers with skin pathology including but not limited to eczema, psoriasis, acne, and other inflammatory dermatoses will be asked to undergo various procedures to evaluate their sleep and skin health. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analysis of Sleep Pattern via Actigraphy, Polysomnography & Questionnaires | The volunteers may be asked to wear a wrist actigraph to measure movement. This watch would be worn for 24 hours per day for 7-14 days. The volunteer may also be asked to fill out questionnaires regarding their sleep patterns. Note: Other methods of assessing sleep patterns may also be used including a portable polysomnogram or a standard, overnight sleep study. | 7-14 days | 
| Evaluation of skin (both in terms of skin aging and skin disease) | The volunteers may have their skin evaluated for skin aging using the SCINEXA tool. Volunteers with psoriasis may have their skin evaluated via PASI and/or PGA assessments. Volunteers may have photographs taken to compare clinical appearance with laboratory and research findings. | Only once during the study or at specific time points depending on what other procedures are being performed | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sample Analysis (from skin, blood, urine, saliva and hair follicle samples) | Skin, blood, urine, saliva and hair follicle samples may be collected from some volunteers to look at various markers related to sleep, the circadian rhythm and skin disease. | Only once during the study or at specific time points depending on what other procedures are being performed | 
| Skin Barrier Recovery (via TEWL measurement) | Skin barrier recovery via Transepidermal Water Loss (TEWL) measurement may be assessed in some volunteers. | Only once during the study or at specific time points depending on what other procedures are being performed | 
| MED Testing & Recovery from UV-induced erythema | MED Testing & Recovery from UV-induced erythema may be assessed in some volunteers. | 24 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Sleep, Skin, Circadian Rhythm