Research of Revascularization in Immature Teeth With Periapical Periodontitis

Study Overview
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Brief Summary
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Revascularization is an alternative new treatment of immature permanent teeth with necrotic pulp nowadays while apexification is the traditional therapy. The investigators suppose that revascularization is superior to apexification at developing the root of immature permanent teeth and reducing the risk of root fracture,and the research is designed.

Detailed Description
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The investigators design to collect a group of patients presenting immature permanent teeth with periapical periodontitis in certain criterion. The investigators will divide the patients into two groups randomly. One group will get treated with revascularization while the other with apexification. The investigators want to evaluate the short-term and long-term effects of the two groups to get a conclusion of the clinical value of revascularization.

Official Title
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Randomized Controlled Research of Revascularization in Immature Permanent Teeth With Periapical Periodontitis

Conditions
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Periapical Periodontitis

Intervention / Treatment
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* Procedure: revascularization
* Procedure: apexification


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: clinical diagnosis of periapical periodontitis must be immature permanent teeth must be local Guangzhou Exclusion Criteria: blood disease residual root that is advised to extract serious periodontitis women in pregnancy

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: revascularization<br>revascularization is is an alternative new treatment of immature permanent teeth with necrotic pulp. The use of triple antibiotic paste is followed by Induction of bleeding from the apical root during this intervention. | Procedure: revascularization<br>* revascularization include 3 steps: root disinfected,induction of bleeding and revascularization include 3 steps: root disinfected,induction of bleeding and sealing<br>|
| Active Comparator: apexification<br>apexification is a traditional therapy of immature permanent teeth with necrotic pulp.calcium hydroxide is served as medication to induce the developing of root . | Procedure: apexification<br>* apexification uses calcium hydroxide as root medication<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evidence of lesion healing confirmed by cone beam computed tomography |  | one year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Immature Permanent Teeth