Comparison Between Uterine Artery Doppler and Placental Vascular Indices in Prediction of Preeclampsia

Study Overview
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Brief Summary
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• Preeclampsia is a multisystem disorder that can cause considerable maternal and fetal morbidity and mortality. Late preeclampsia (with delivery >34 weeks) is more frequent and less serious than early preeclampsia (with delivery <34 weeks). Poor early placentation has been especially associated with early disease. Early identification of women at risk of preeclampsia is currently a crucial aim of antenatal care since they may benefit from prophylactic treatment and increased surveillance.

Detailed Description
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The introduction of three-dimensional (3D) ultrasound techniques, with the option of calculating placental volume and measuring vascular indices, has created an excellent opportunity to study early changes in the uteroplacental circulation space, which includes the maternal spiral arteries and the intervillous space. This technology may allow a more direct evaluation of the abnormal placentation process thought to herald the development of preeclampsia. The aim of this study was to assess the usefulness of placental volume and 3D vascular indices as reliable predictors of early preeclampsia in comparison to uterine artery Doppler

Official Title
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Comparison Between Uterine Artery Doppler and Placental Vascular Indices in Prediction of Preeclampsia

Conditions
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Pre-Eclampsia

Intervention / Treatment
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* Device: ultrasound machine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: A. Control group: Pregnant women: Age between 18-35 years Parity: primigravidas and multiparas. Have no history of preeclampsia or eclampsia. Have no history of chronic hypertension. Not diabetic. Not have antiphospholipid syndrome. Not have autoimmune disease such as SLE. B. High risk group: Pregnant women with: History of preeclampsia -Eclapmsia Chronic hypertension Diabetic Antiphospholipid syndrome. Autoimmune syndrome such as SLE. Exclusion Criteria: • Smoking Dichorionic placentae Fetal anomaly Uterine fibroid at the site of placental implantation Subchorionic hematoma

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| control group<br>Pregnant women: Age between 18-35 years Parity: primigravidas and multiparas. Have no history of preeclampsia or eclampsia. Have no history of chronic hypertension. Not diabetic. Not have antiphospholipid syndrome. Not have autoimmune disease such as SLE | Device: ultrasound machine<br>* Ultrasound machine with a vocal software<br>|
| High risk group<br>Pregnant women with: History of preeclampsia -Eclapmsia Chronic hypertension Diabetic Antiphospholipid syndrome. Autoimmune syndrome such as SLE. | Device: ultrasound machine<br>* Ultrasound machine with a vocal software<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| placental vascular indices in prediction of preeclampsia | placental vascular indices in prediction of preeclampsia compared to uterine artery doppler in prediction of preeclampsia | one year |