Mini-Mental State (MMS-LS) and Sign Language

Study Overview
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Brief Summary
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In France the prevalence of pre-lingual deafness is between 1 and 1.4 per 1000 habitants, and according to very conservative estimates, about 44 000 deaf persons use the sign language. Additionally, the prevalence of dementia in France is close to 1% (850 000 dements for a total population of 65 millions). The prevalence of dementia in pre-lingual deaf adults has also been described and is between 1 and 1.4 /100 000 habitants. The Mini Mental State Examination (MMSE) of Folstein is a test recommended to perform the cognitive evaluation for the detection of mental disorders including dementia, and a consensual French version exists prepared by GRECO (Group of Research and Cognitive Assessments). However, to date, there are no simple, rapid and validated screening tests to study cognitive disorders in deaf persons who use the sign language. The only tests available allow a late diagnosis avoiding an optimal treatment of the patients.

Detailed Description
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The objective of this study is to assess the intrinsic quality of the tool MMS-LS, a mini-mental state examination that has been adapted to the sign language in order to monitor cognitive disorders in deaf people who speak sign language.

Official Title
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Transposition of the Mini-Mental State in Sign Language

Conditions
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Prelingual Deafness, Retention Disorders, Cognitive

Intervention / Treatment
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* Behavioral: application of the mini-mental state test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adults> 18 years Pre-lingual deafness Use of French sign language Exclusion Criteria: Refusal to sign the consent Severe visual impairment with lower acuity (less than 0.5) Severe motor difficulties impeding the practice of sign language

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: deaf persons with potential dementia<br> | Behavioral: application of the mini-mental state test<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assessment of internal consistency of MMS-LS test for the diagnosis of cognitive impairment among deaf patients by a correlation analysis followed by Cronbach's alpha test |  | At baseline, 1 year and 2 years follow-up visits | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Description of MMS-LS test results | Explanatory Factors are: age, education level, characteristics of the sign language(fluency level, learning age, usage frequency, usage by other family members) | Baseline | 
| Diagnostic performance and predictive values of MMS-LS test for acquired dementia. | Sensitivity, specificity, positive and negative predictive values. | Baseline, 1 year and 2 years follow-up visits | 
| Correlation between MMS-LS score and CDR level | We also check that patients having a suspicious CDR (0.5) have a superior MMS-LS score compared to patients having a CDR ≥ 1. | Baseline, 1 year and 2 years follow-up visits | 
| Diagnostic performance and predictive values of MMS-LS test for suspected dementia. | Sensitivity, specificity, positive and negative predictive values | Baseline, 1 year and 2 years follow-up visits | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Prelingual Deafness, Retention Disorders, Cognitive, Sign language, Mini-Mental State