The Effect of Aerobic Exercise on Cognitive Function and Sleep Quality in Individuals With Multiple Sclerosis

Study Overview
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Brief Summary
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In addition to the typical motor and sensory impairments, individuals with multiple sclerosis (MS) often experience cognitive dysfunction and sleep disturbances. Cognitive impairment occurs in 40 % - 70% of patients with MS. In addition, sleep problems in individuals with MS are very common, and approximately 50% of patients with MS have a diagnosable sleep disorder. The research believes that aerobic exercise improve cognitive function and improve sleep quality.

Official Title
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The Effect of Aerobic Exercise on Cognitive Function and Sleep Quality in Individuals With Multiple Sclerosis

Conditions
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Multiple Sclerosis

Intervention / Treatment
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* Other: aerobic exercise
* Other: home exercise program


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: diagnosis of relapsing remitting or secondary progressive MS score 3-7 on the EDSS score < 55 on the Symbol Digit Modalities Test score > 5 on the Pittsburgh Sleep Quality Index Exclusion Criteria: history of alcohol/drug abuse or nervous system disorder other than MS severe physical, neurological, or sensory impairments that would interfere significantly with testing developmental history of learning disability or attention-deficit/hyperactivity disorder relapse and/or corticosteroid use within four weeks of assessment unable to give consent uncorrected vision loss that would interfere significantly with testing score less than 24 on MMSE Acute ischemic cardiovascular event or coronary artery bypass surgery less than 3 months ago Either unable to physically perform the exercise test using the recumbent stepper or demonstrate absolute indications for terminating exercise that follows the American College of Sports Medicine's (ACSM) guidelines Uncontrolled blood pressure with medication (BP > 190/110mmHg)

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Aerobic Exercise<br>3x/week supervised moderate intensity aerobic exercise on recumbent stepper | Other: aerobic exercise<br> <br> |
| Active Comparator: Home exercise program<br>Walking and stretching exercises performed 3x/week for 30 minutes at intensity considered non-aerobic | Other: home exercise program<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Cognitive Function |  | Baseline to Month 3 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Sleep Quality |  | Baseline to Month 3 |