Assessment of Regenerative Potential of Mature Permanent Teeth With Necrotic Pulps Using Two Revascularization Protocols. (In Vivo Study)

Study Overview
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Brief Summary
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Regenerative endodontic procedures have been used to successfully treat human mature permanent teeth with necrotic pulps and apical periodontitis. Many researchers have begun to apply regenerative endodontic procedures to mature teeth in adult patients. Several clinical case reports have shown complete resolution of signs and symptoms of pulp necrosis in mature teeth, even those with large periapical lesions, as well as signs of pulp canal obliteration. thevaim of this study is To assess the regenerative potential of mature permanent teeth with necrotic pulps with platelet-rich fibrin (PRF) and blood clot using radiographic and clinical methods.

Official Title
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Assessment of Regenerative Potential of Mature Permanent Teeth With Necrotic Pulps Using Two Revascularization Protocols. (In Vivo Study)

Conditions
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Apical Periodontitis

Intervention / Treatment
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* Other: Method


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with mature teeth. Patients with periapical periodontitis. Maxillary anterior teeth only will be involved. Patients should be free from any systemic disease that may affect normal healing and predictable outcome. Patients who will agree to the consent and will commit to follow up period. Exclusion Criteria: Patients with immature roots. Patients with any systemic disease that may affect normal healing. Patients with swelling. Pregnant females. Patients who could/would not participate in a 1 year follow up. Patients with fistula. Patients with old age. Teeth with periodontal involvement. Teeth with vertical root fractures. Unrestorable teeth.

Ages Eligible for Study
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Minimum Age: 11 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Blood clotting protocol for pulp regeneration<br>pulp regeneration for mature teeth using blood clotting protocol | Other: Method<br>* treatment of mature teeth with apical periodontitis<br>|
| Experimental: platelet rich fibrin for pulp regeneration<br>pulp regeneration for mature teeth using platelet rich fibrin (PRF) | Other: Method<br>* treatment of mature teeth with apical periodontitis<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| clinical success | pulp vitality testing using electric pulp tester which detect response of pulp to electric current | 9 months | 
| radiographic success | healing of apical periodontitis by detecting change in apical radiolucency and absences of apical bone resorption | 9 months |