Feeding Behavior and Taste Sensitivity Before and After Liver or Renal Transplantation

Study Overview
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Brief Summary
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This study evaluates the influence of the taste sensitivity, of food preferences and of the reward system on the energetic balance before and after liver transplantation in cirrhotic patients and after kidney transplantation in renal failure patients

Detailed Description
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Background and Aims: Protein-energy malnutrition is associated to cirrhosis with a high prevalence and greatly increases the morbidity and mortality of the disease. Malnutrition results of numerous causes including intestinal malabsorption, increased energy resting expenditure, metabolism disturbances, impaired sensory taste and changes in food preferences which might participate to a reduction in food intake. The aim of this study was to determine the relationships that may exist between taste sensitivity and food preferences on the one hand, eating habits, nutritional status, energy balance and biological parameters including amino acids on the other hand in patients with end-stage cirrhosis and in patients with renal failure. Fifteen end-stage cirrhotic patients and 15 renal failure patients will be included and matched with 30 healthy subjects. The following parameters will be evaluated during a morning testing session: gustatory sensitivity using a triangular detection threshold method for sweet, salty and umami solutions; preferences for fat- and carbohydrate-rich foods using the PrefQuest score; liking for six foods (protein-, carbohydrate- and fat-rich foods) and wanting for 18 foods (photographs); hunger sensation; energy intake (24 h ingested food); body composition (BMI and impedancemetry); resting energy expenditure (indirect calorimetry) and physical activity (questionnaire). Several plasmatic parameters (amino-acids, leptin, ghrelin, lipid profile) will be also determined.

Official Title
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Feeding Behavior and Taste Sensitivity Before and After Liver or Renal Transplantation

Conditions
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Cirrhosis, Food Preferences, Taste Disorders, Protein-Energy Malnutrition, Chronic Renal Failure

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: written consent patients in waiting renal transplant patients in waiting liver transplant Exclusion Criteria: chronic infection acute infection cancer antibiotic treatments alcool abuse pregnant woman specific or restrictive diet

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cirrhotic subjects<br>15 cirrhotic patients in end-stage in waiting a graft | |
| Chronic kidney disease subjects<br>15 chronic kidney disease patients in end-stage in waiting a graft | |
| Healthy subjects<br>30 healthy subjects to compare | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Energy expenditure | evice: indirect calorimetry (sensormedics) | two years | 
| body composition | Device: Multifrequency bio-impedancemetry (aminostats) | 2 years | 
| amino acids profil in plasma | Biological measurments | 2 years | 
| Food preferences | Device: Treshold taste detection | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cirrhosis, reward system, taste sensitivity, chronic renal failure