Faecal Incontinence in Prostate Cancer Survivors Treated Whith Radiotherapy

Study Overview
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Brief Summary
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The objective of the study is to determine the incidence of faecal incontinence in prostate cancer survivors treated with moderately hypofractionated radiation therapy and correlate the dose received by the anal sphincter with the degree of faecal incontinence.

Detailed Description
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The investigators know that high doses of irradiation in the anal sphincter are associated with more chronic fecal leaks in survivors irradiated by normofractionated radiotherapy prostate cancer. The safe dose of irradiation of the anal sphincter with radiotherapy modern techniques (volumetric modulated arc therapy with moderately hypofracctionation) is unknown. Urgency and faecal incontinence greatly affects the quality of life of these patients. Therefore, it is interesting to implement strategies to protect the anatomical structures involved in fecal continence. The objective of the study is to determine the incidence of faecal incontinence in prostate cancer survivors treated with modern moderately hypofractionated radiation therapy and correlate the dose received by the anal sphincter with the degree of faecal incontinence. The investigators also want to evaluate the quality of life of these patients

Official Title
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Faecal Incontinence in Prostate Cancer Survivors Treated With Moderately Hypofractionated Radiotherapy

Conditions
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Faecal Incontinence, Prostate Cancer

Intervention / Treatment
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* Radiation: hypofractionated radiotherapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Prostate cancer survivors treated in our department by hypofractionated radiotherapy Exclusion Criteria: Relapse of prostate cancer Other active cancer Mental disorder

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Male

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Radiation: hypofractionated radiotherapy|volumetric modulated moderately fractionated arc therapy|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| faecal incontinence after prostate radiation therapy | grade of faecal incontinence in prostate cancer patients | before radiotherapy (basal) | 
| faecal incontinence after prostate radiation therapy | grade of faecal incontinence in prostate cancer survivors | change 2 years after completion of radiotherapy | 
| faecal incontinence after prostate radiation therapy | grade of faecal incontinence in prostate cancer survivors | change 3 years after completion of radiotherapy | 
| faecal incontinence after prostate radiation therapy | grade of faecal incontinence in prostate cancer survivors | change 4 years after completion of radiotherapy | 
| faecal incontinence after prostate radiation therapy | grade of faecal incontinence in prostate cancer survivors | change 5 years after completion of radiotherapy | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of life after prostate radiation therapy | Quality of life in prostate cancer survivors comparing continents patients and incontinents patients | 3 years after completion of radiotherapy | 
| Quality of life after prostate radiation therapy | Quality of life in prostate cancer survivors comparing continents patients and incontinents patients | 5 years after completion of radiotherapy | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hypofractionated radiotherapy, quality of life, cancer survivors