A Prospective Cohort Study for Patients With Adrenal Diseases

Study Overview
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Brief Summary
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The purpose of this study is to investigate the pathologic features, complications, and prognostic factors of functioning adrenal adenoma and suggest follow-up algorithms for adrenal incidentaloma.

Detailed Description
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The investigators will recruit 150 patients annually for 10 years (adrenal incidentaloma 100 patients, pheochromocytoma 15 patients, primary aldosteronism 25 patients, adrenal cushing syndrome 10 patients, adrenocortical carcinoma 2 patients) and perform hormonal, biochemical, imaging exam according to each disease's clinical guidelines. Based on this, the investigators will identify pathologic features, complications, and prognostic factors of each disease.

Official Title
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A Prospective Cohort Study for Patients With Adrenal Diseases

Conditions
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Adrenal Adenoma, Cushing Syndrome, Pheochromocytoma, Adrenal Incidentaloma, Adrenocortical Carcinoma, Primary Hyperaldosteronism

Intervention / Treatment
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* Other: Hormone study and Imaging study


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adults, male or female aged 19 years or older newly diagnosed with adrenal disease such as adrenal incidentaloma, pheochromocytoma, primary aldosteronism, adrenal cushing syndrome, adrenocortical carcinoma Exclusion Criteria: previous or current history of adrenal diseases using oral or intravenous steroids history of major depressive disorder history of chronic alcoholics history of any cancer with suspicious adrenal metastasis those with acute illness (ex- patients with acute coronary syndrome within 4 weeks, acute febrile disease)

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Non-functioning adrenal incidentaloma<br>patients who were diagnosed with non-functioning adrenal incidentaloma on computed tomography or magnetic resonance imaging | Other: Hormone study and Imaging study<br>* Blood (basal hormone and follow up hormone study) Imaging examination including computed tomography scan or magnetic resonance imaging<br>|
| Pheochromocytoma<br>patients who were diagnosed with pheochromocytoma biochemically or histologically | Other: Hormone study and Imaging study<br>* Blood (basal hormone and follow up hormone study) Imaging examination including computed tomography scan or magnetic resonance imaging<br>|
| Primary aldosteronism<br>patients who were diagnosed with primary aldosteronism by saline loading test | Other: Hormone study and Imaging study<br>* Blood (basal hormone and follow up hormone study) Imaging examination including computed tomography scan or magnetic resonance imaging<br>|
| Adrenal cushing syndrome<br>patients who were diagnosed with adrenal cushing syndrome by dexamethasone suppression test and 24 urine free cortisol test. | Other: Hormone study and Imaging study<br>* Blood (basal hormone and follow up hormone study) Imaging examination including computed tomography scan or magnetic resonance imaging<br>|
| Adrenocortical carcinoma<br>patients who were diagnosed with adrenocortical carcinoma by imaging study or histologic exam | Other: Hormone study and Imaging study<br>* Blood (basal hormone and follow up hormone study) Imaging examination including computed tomography scan or magnetic resonance imaging<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of participants in remission | Remission rate | Up to 10 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complication of adrenal disease | all complications including deaths | Up to 10 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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algorithms, adrenal adenoma, cushing syndrome, pheochromocytoma, adrenal incidentaloma, adreocortical carcinoma, primary hyperaldosteronism