Effects of Coenzyme Q10 Supplementation on Oxidative Stress, Antioxidant Capacity, Inflammatory Responses, Fatigue Elimination, and Exercise Performance in Athletes

Study Overview
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Brief Summary
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The aims of the study are 1) to compare the differences in plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances in athletes (i.e., soccer, and taekwondo players) and healthy non-athletes; 2) to investigate the relationship between plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances; 3) to explore the influence on plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances after 12 weeks of coenzyme Q10 intervention (150 mg/day and 300 mg/day).

Detailed Description
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The long-term high-amount and -intensity exercise training could cause oxidative damage, muscle impairment, inflammation and exercise fatigue to athletes easily. Such above conditions will affect the exercise performances and health of athletes. The aims of the study are 1) to compare the differences in plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances in athletes (i.e., soccer, and taekwondo players) and healthy non-athletes; 2) to investigate the relationship between plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances; 3) to explore the influence on plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances after 12 weeks of coenzyme Q10 intervention (150 mg/day and 300 mg/day). Eventually, these results of this study can provide the information for the known to improve the oxidative stress, anti-oxidation and inflammation internal to the bodies of athletes for various competitions. As a consequence, the athletic performances can be further enhanced.

Official Title
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Effects of Coenzyme Q10 Supplementation on Oxidative Stress, Antioxidant Capacity, Inflammatory Responses, Fatigue Elimination, and Exercise Performance in Athletes From Different Sports: Cross-sectional, Interventional, and Follow-up Studies

Conditions
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Athlete

Intervention / Treatment
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* Other: Placebo
* Dietary Supplement: Coenzyme Q10


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Athletes (soccer and taekwondo players) Exclusion Criteria: Antioxidant vitamins users Statins or Aspirin therapy.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: placebo-control
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Placebo<br>Placebo | Other: Placebo<br>* Placebo (dextrin)<br>|
| Experimental: Q10-150<br>coenzyme Q10 150 mg/d. | Dietary Supplement: Coenzyme Q10<br>* 150 mg or 300 mg<br>|
| Experimental: Q10-300<br>coenzyme Q10 300 mg/d. | Dietary Supplement: Coenzyme Q10<br>* 150 mg or 300 mg<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| malondialdehyde (MDA) | MDA (micromol/L) will measure by thiobarbituric acid reacting substance. | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Antioxidant capacity | Total antioxidant capacity (TAC) was measured by a Trolox equivalent antioxidant capacity assay in serum and erythrocytes. | 12 weeks | 
| high sensitivity C-reactive protein (hs-CRP) | hs-CRP will measure by immunoturbidimetry. | 12 weeks | 
| creatine kinase (CK) | serum CK will measure by enzymatic method. | 12 weeks | 
| Lactate dehydrogenase (LDH) | serum LDH will measure by enzymatic method. | 12 weeks | 
| one-repetition maximum (1-RM) | 1RM measurements will report in kilograms for data analysis. | 12 weeks | 
| Glucose | mmol/L | 12 weeks | 
| HbA1C | HbA1C will measure by an automated glycated hemoglobin analyzer | 12 weeks | 
| Insulin | insulin will measure by an automated chemistry analyzer | 12 weeks |