Resistance Training in Diabetic Elder Patients

Study Overview
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Brief Summary
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The purpose of this study is to investigate the effect of a 12-week progressive resistance training program on the skeletal muscle function, glycemic control, functional capacity, and quality of life in the elderly with type 2 diabetes mellitus.

Official Title
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Effects of Resistance Training on Muscle Dysfunction in Elderly Patients With Type 2 Diabetes Mellitus

Conditions
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Diabetes Mellitus, Type 2

Intervention / Treatment
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* Behavioral: Resistance exercise
* Behavioral: Usual care


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 65 years old or older no clinical diagnosis of cardiovascular disease patients with or without type 2 diabetes mellitus Exclusion Criteria: glycated hemoglobin > 10% pulmonary disease cancer cognitive dysfunction any neurological or musculoskeletal disease that will affect exercise performance

Ages Eligible for Study
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Minimum Age: 65 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Usual care<br>Participants in this arm will receive a brochure specific for type 2 diabetes mellitus about the general principles of exercise, nutrition, and diet. They are asked to maintain their activity level. | Behavioral: Usual care<br>* Participants in this arm will receive a brochure specific for type 2 diabetes mellitus about the general principles of exercise, nutrition, and diet. They are asked to maintain their activity level.<br>|
| Experimental: Resistance exercise<br>Progressive resistance training, 3 times a week for 12 weeks | Behavioral: Resistance exercise<br>* Progressive resistance exercise training, 3 times a week for 12 weeks.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximal muscle strength | This outcome measure includes upper and lower body maximal muscle strength. | Twelve weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physical body function | This outcome will be assessed by one minute sit-to-stand test and timed Up and Go test. | Twelve weeks | 
| Quality of life | This outcome measure will be assessed by the diabetes-specific questionnaire. | Twelve weeks | 
| Waist circumference |  | Twelve weeks | 
| Body mass index | This outcome measure includes the measurements of body height and body weight. | Twelve weeks | 
| Functional capacity | Peak oxygen consumption will be determined by graded exercise test to assess functional capacity. | Twelve weeks | 
| Blood biochemical parameters | This outcome measure includes the analysis of fasting glucose, glycated hemoglobin, lipid profile, C-reactive protein, and related metabolites. | Twevle weeks | 
| Muscle oxygenation | Muscle oxygenation will be assessed during exercise | Twelve weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Diabetes mellitus, Resistance exercise, Elderly, Skeletal muscle dysfunction, Metabolomics