the Effect of the Transversus Abdominis Plane (TAP) Block on the Minimal Laparotomy : a Randomized Controlled Trial

Study Overview
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Brief Summary
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Transversus abdominis plane block (TAP block) is a new regional block for abdominal wall.It had been reported the effect of post-operative pain control in minor abdominal surgery, such as inguinal hernia repair and appendectomy. On the other hand, because of the accurate of the pre-operative images, the minimal laparotomy for colon cancer was accomplished. Thus, the purpose of this study is to investigate the effect, such as analgesic effect, hemodynamic stability, and post-operative morphine consumption, of TAP block in minimal laparotomy.

Detailed Description
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outcome measures: Hemodynamic parameters (mean artery pressure, heart rate): recorded at time points of before induction of general anesthesia (baseline), after tracheal intubation immediately, after surgery started 1, 2, 3, 4, 5, 10, 15, 20, 25, and 30 min; then recorded them every 10 mins. Post-operative morphine consumption: recorded morphine consumption at the time intervals of post-operative 0 6 h, 6 12 h, 12 24 h, 24 36 h, and 36 48 h ,respectively. The total amount of morphine consumption was also counted.

Official Title
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the Effect of the Transversus Abdominis Plane (TAP) Block on the Minimal Laparotomy : a Randomized Controlled Trial

Conditions
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Colon Cancer

Intervention / Treatment
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* Procedure: Transversus Abdominis Plane block


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Anesthesiologists physical status I-III, ≧ 18 years of age, and needed double-lumen endotracheal tube (DLT) for thoracic surger Exclusion Criteria: increased risk for regurgitation and pulmonary aspiration, history of gastroesophageal reflux, and pregnancy a tracheostomy or prolonged ventilation on ICU was planned, patients were also excluded

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: morphine consumption<br> | Procedure: Transversus Abdominis Plane block<br>* TAP BLOCK: dosage form: 0.5% bupivacaine 75mg with 2% xylocaine 300 mg mixed dosage: total 30 ml frequency: single shot duration: 12 18 hours upon to the regional anesthetics choose<br>* Other names: TAP block;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| amount of post-operative morphine consumption |  | post-operative 48 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| evaluation of post-operative pain status using visual analog scale (VAS) and superimposed face pain severity scale |  | post-operative 48 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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minimal laparotomy, TAP block, morphine consumption, post-operative analgesia