Fertility and Ovarian Reserve Function in the Patient With Inflammatory Bowel Disease

Study Overview
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Brief Summary
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ECCO consensus, the fertility would decline in activity inflammatory bowel disease(IBD), because of anus lesions and pelvic abscess, or who underwent surgery, especially in patients with ileal pouch anal anastomosis (IPAA) storage.The study on fertility in inflammatory bowel disease were almost epidemiological investigation, the lack of objective evaluation of fertility, and controversial.This study will explore the fertility, ovarian reserve function and the pregnancy outcomes in patients with IBD.

Official Title
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Fertility and Ovarian Reserve Function in the Patient With Inflammatory Bowel - a Cross-sectional Survey and Case Control Study

Conditions
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Fertility Disorders, Ovarian Reserve Function, Pregnancy Outcomes

Intervention / Treatment
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* Other: Anti Mueller hormone
* Other: Estrogen
* Other: Follicle-Stimulating Hormone
* Other: Antral alveolar cell count


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Inflammatory bowel disease 17-40 years old female Exclusion Criteria: in pregnancy or lactation a drug that has been or is being used known to affect ovarian function, such as cyclophosphamide reproductive system diseases unrelated to disease or treatment of inflammatory bowel disease, such as hysterectomy, pelvic radiotherapy after surgery, after ovariectomy, polycystic ovary syndrome, endometriosis, ovarian granulosa cell tumor other endocrine diseases, such as prolactin, hyperthyroidism, lead to endocrine disorders; malignant tumor

Ages Eligible for Study
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Minimum Age: 17 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: IBD patients<br>IBD patients, 17-40 years old, female | Other: Anti Mueller hormone<br>* used to assess ovarian reserve parameters<br>Other: Estrogen<br>* used to assess ovarian reserve parameters<br>Other: Follicle-Stimulating Hormone<br>* used to assess ovarian reserve parameters<br>Other: Antral alveolar cell count<br>* used to assess ovarian reserve parameters<br>|
| Other: healthy control<br>17-40 years old , female, without any gynecological disease | Other: Anti Mueller hormone<br>* used to assess ovarian reserve parameters<br>Other: Estrogen<br>* used to assess ovarian reserve parameters<br>Other: Follicle-Stimulating Hormone<br>* used to assess ovarian reserve parameters<br>Other: Antral alveolar cell count<br>* used to assess ovarian reserve parameters<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The AMH of IBD patients is lower than that of healthy women | AMH is used to assess ovarian reserve function | 1 month | 
| The E2 of IBD patients is lower than that of healthy women | E2 is used to assess ovarian reserve function | 1 month | 
| The FSH of IBD patients is lower than that of healthy women | FSH is used to assess ovarian reserve function | 1 month | 
| The AFC of IBD patients is lower than that of healthy women | AFC is used to assess ovarian reserve function | 1 month |