Pediatric Hypertension Registry (PHREG)

Study Overview
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Brief Summary
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Pediatric hypertension is increasingly common and is a precursor for adult cardiovascular and renal disease. But even during childhood, hypertension is associated with significant morbidity, including cognitive impairment and organ damage. However, the cause of pediatric hypertension, the response to treatment, and the mechanisms behind organ damage are incompletely understood. Due to these limitations, there are no first-line medications, and treatment is often inadequate. An improved comprehension of the course of pediatric hypertension could enhance clinical care. The goal of this proposal is to create a registry of patients with hypertension to better enable research into this important disease. This patient registry will enhance the investigators ability to quickly collect and analyze data for research studies.

Detailed Description
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The investigators will include all subjects evaluated at the Brenner Children's Hospital Pediatric Nephrology clinic since January 1st, 2013 with a diagnosis of high blood pressure confirmed with three separate blood pressure measurements >=90th percentile for age, sex, and height, or >120/80 mmHg. The investigators will exclude patients whose initial evaluation occurred on or after their 18th birthday.

Official Title
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Pediatric Hypertension Registry (PHREG)

Conditions
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Hypertension, Pediatric Disorder

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Patients at one of the following : Wake Forest Baptist Health Brenner Children's Hospital Pediatric Nephrology clinic Emory University Pediatric Nephrology Diagnosis of hypertension confirmed with three separate blood pressure measurements Diagnosis after January 2013 >90th percentile for age, sex, height, or >120/80. Exclusion Criteria: - Patients whose initial evaluation occurred on or after their 18th birthday.

Ages Eligible for Study
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Maximum Age: 17 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Retrospective cohort<br>The cohort of patients seen prior to the implementation of a standardized clinical management protocol on 10/01/2017 whose data is collected retrospectively. | |
| Prospective cohort<br>The cohort of patients seen initially seen after implementation of a standardized clinical management protocol on 10/01/2017 whose data is collected prospectively. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood pressure | Auscultated blood pressure measurements in clinic | 10 years | 
| Left ventricular hypertrophy | Left ventricular hypertrophy and other cardiac structural/function changes on echocardiograms | 10 years | 
| Albuminuria | Urinary albumin-to-creatinine (>30 mg/g) | 10 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ambulatory blood pressure | Ambulatory blood pressure monitoring data | 10 years | 
| Renal function | Glomerular filtration rate | 10 years | 
| Uric acid | Serum uric acid | 10 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Hypertension