Efficacy Comparison of Two Kinds of Treatment in Treating Dry Eye Caused by Meibomian Gland Dysfunction

Study Overview
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Brief Summary
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This study aims to evaluate the efficacy of intense pulsed light in treating dry eye caused by meibomian gland dysfunction and make a comparison between the traditional treatment.

Official Title
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Efficacy Comparison of Two Kinds of Treatment in Treating Dry Eye Caused by Meibomian Gland Dysfunction

Conditions
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Dry Eye Syndrome

Intervention / Treatment
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* Device: intense pulsed light
* Drug: Tobramycin and Dexamethasone Ophthalmic Ointment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with dry eye syndrome and diagnosed as MGD Exclusion Criteria: an infection or inflammatory disease; ocular surgical history with in the last 3 months SGOGREN SYNDROME

Ages Eligible for Study
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Minimum Age: 26 Years
Maximum Age: 78 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: traditional treatment group<br>Subjects in this group are treated by tobramycin and dexamethasone ophthalmic ointment qn and artificial tears qid. | Drug: Tobramycin and Dexamethasone Ophthalmic Ointment<br> <br> |
| Experimental: IPL treatment group<br>Subjects in this group are treated with 3 cycles of intense pulsed light of 4 weeks interval and artificial tears qid. | Device: intense pulsed light<br>* Intense pulse light (IPL) has been used in dermatology practices for several years as a treatment for rosacea and acne.IPL uses Xenon flashlamp to emit wavelengths of light from 400 to 1200nm. When placed on the light, a filter restricts the wavelength to the visible light range of *500nm.In 2007-2008, an IPL treatment technology-the Diamond Q4 by DermaMed Solutions-was specifically configured to our specifications with the goal of stimulating secretion of normal meibum via skin treatment effects on the meibomian glands. It was discovered that dry eye patients are better positioned for gland expression, as IPL seems to liquefy the abnormal viscous meibum and dilate the glands.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ocular Surface Disease Index (OSDI) | normal value：<13 abnormal value：≥ 13 | through study completion,an average of 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The concentrations of inflammatory cytokines such as IL-1、IL-6 and IL-8 |  | through study completion,an average of 6 months | 
| breakup time of tear film （BUT） | normal value：>10s abnormal value：≤ 10s | through study completion,an average of 6 months | 
| Corneal Fluorescein Stain(CFS) |  | through study completion,an average of 6 months | 
| Eyelid ester discharge ability score |  | through study completion,an average of 6 months | 
| Eyelid ester trait ratings |  | through study completion,an average of 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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IPL, MGD