linjc16/ctgov huggingface dataset:
Combined Drug Therapy in Lateral Fragility Fractures of the Femur

Study Overview
=================
Brief Summary
-----------------
It was conducted a prospective study with a series of 50 patients treated by intramedullary nail using Clodronic acid and Vitamin D (study group including 25 patients) and patients with the same fractures treated with Vitamin D alone (control group including 25 patients). One independent observer performed clinical, biochemical and functional evaluations at T0 (1st day post-surgery) and at T1 (12 months later) Biochemical markers (serum calcium level, serum phosphate level, PTH (parathormone), Vitamin D, serum C-terminal telopeptide), VAS (Visual Analogic Scale) and HHS (Harris Hip Score) score, and femur densitometric views were administered at each evaluation.

Official Title
-----------------
The Effect of Combined Drug Therapy in Lateral Fragility Fractures of the Femur:a Clinical Study

Conditions
-----------------
Femur Fracture

Intervention / Treatment
-----------------
* Drug: Clodronic Acid


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: femur fractures type 31-A1, A2, (Muller ME, Nazarian S, Kock P et al.); age 60 - 85 years; co-operative patients; Body Mass Index (BMI) < 30 Kg/m²; patients treated by intramedullary nailing surgery (PFNA Synthes®); patients with osteoporosis disease if T-Score< -2,5; Exclusion Criteria: patients with heart, kidney, neurological diseases; patients with metabolic and systemic disease (rheumatoid arthritis, diabetes mellitus); previous surgery or severe osteoarthritis of lower limbs; specific drugs treatments such as anticoagulants or psychiatric drugs.

Ages Eligible for Study
-----------------
Minimum Age: 60 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients treated with Vitamin D<br> | |
| patients treated with Vitamin D and Clodronic Acid<br> | Drug: Clodronic Acid<br>* Osteoporotic fracture treated with surgical and medical therapy<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Visual Analogic Scale | The Hip Pain was quantified using the Visual Analogic Scale ranging between 0 (no pain) and 10 points (worst imaginable pain). | Day 1; Month 12 (after surgey) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
fragility lateral femoral fractures, bisphosphonates, clodronic acid, bone density
Stem Cell Therapy in Autism Spectrum Disorders

Study Overview
=================
Brief Summary
-----------------
The purpose of this study was to study the effect of stem cell therapy on common symptoms in patients with autism spectrum disorders

Official Title
-----------------
Open Label Study of Autologous Bone Marrow Mononuclear Cells in Autism Spectrum Disorders

Conditions
-----------------
Autism Spectrum Disorders

Intervention / Treatment
-----------------
* Procedure: Autologous bone marrow mononuclear cell transplantation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosed cases of any type of autism spectrum disorders age above 6 months Exclusion Criteria: presence of acute infections such as Human immunodeficiency virus/Hepatitis B Virus/Hepatitis C Virus malignancies bleeding tendencies pneumonia renal failure severe liver dysfunction severe anemia [Hemoglobin < 8] any bone marrow disorder space occupying lesion in brain other acute medical conditions such as respiratory infection and pyrexia

Ages Eligible for Study
-----------------
Minimum Age: 6 Months
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Stem cell<br>autologous bone marrow mononuclear cell transplantation | Procedure: Autologous bone marrow mononuclear cell transplantation<br>* Intrathecal autologous bone marrow mononuclear cell transplantation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improvement in the scales for Autism spectrum disorders |  | Six months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Positron Emission Tomography- computed tomography to study change in brain metabolism |  | six months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
autism spectrum disorders, stem cells
Association Between ALDH2 Gene Polymorphism and Atrial Fibrillation

Study Overview
=================
Brief Summary
-----------------
This study is a case-control study. In this study, 2ml of vein blood samples were collected from patients with atrial fibrillation undergoing radiofrequency ablation and those in the control group who underwent electrophysiological examination alone and confirmed no arrhythmia. The purpose of this study is to identify the relationship between the aldehyde dehydrogenase 2 (ALDH2) gene polymorphism and susceptibility to atrial fibrillation, and to explore the relationship between the genotype of ALDH2 SNP and the prognosis of patients with atrial fibrillation undergoing radiofrequency ablation.

Official Title
-----------------
Association Between ALDH2 Gene Polymorphism and Atrial Fibrillation

Conditions
-----------------
Atrial Fibrillation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Signed informed consent; Age 18-85 years old, gender is not limited; ③ Case group: patients with clinical diagnosis of atrial fibrillation who underwent radiofrequency ablation; control group: patients with no arrhythmia confirmed by electrophysiological examination; ④ Able to communicate well with investigators and comply with the entire trial requirements. Exclusion Criteria: Those who cannot understand or refuse to sign the informed consent or follow-up; ②Pregnant women, mentally retarded, mental/cognitive insufficiency and other possible vulnerable groups

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Atrial fibrillation<br>Patients with atrial fibrillation underwent radiofrequency ablation. | |
| Control<br>Patients underwent electrophysiological examination alone and were confirmed no arrhythmia. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| atrial fibrillation recurrence | atrial fibrillation recurrence | 3 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
atrial fibrillation, ALDH2
Decision-making - the Benefit of Bedside CRP Within Ambulance Care

Study Overview
=================
Brief Summary
-----------------
Patients with degreased (DGC) for ambiguous reasons receive low triage priority. Their death risk is triple. Tools are needed to identify the critically ill patients from this group. The triage used today is not effective. The bedside point-of-care measurements are CRP, lactate acid and suPAR (Soluble Urokinase Plasminogen Activator Receptor). Elevated values associate with the probability of critical illness and predict a risk of death.

Detailed Description
-----------------
Purpose: To improve identification and proper prioritization of patients with non-specific symptoms prehospitally, we intend to investigate whether Q-CRP, a rapid test for CRP, correlates with time-critical states in the above-mentioned patient group alone or together with CRP, lactate and suPAR. The primary endpoint is need for hospital care. Material: Patients over 18 years who exhibit non-specific symptoms and transported to the emergency room. Method: In patients with unspecified conditions, defined according to the inclusion template, a venous blood sample was taken prehospitally at the scene by the EMS. Analysis: Significance tests and regression analyzes with 95% CI were used. The diagnostic accuracy of Q-CRP, lactate, suPAR and combinations thereof were compared with optimal boundary values.

Official Title
-----------------
When Triage is Insufficient - the Benefit of Bedside CRP Within Ambulance Care

Conditions
-----------------
Critical Illness

Intervention / Treatment
-----------------
* Diagnostic Test: POC


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients over 18 years who exhibit non-specific symptoms and transported to the emergency room. Exclusion Criteria: Abnormal vitals

Ages Eligible for Study
-----------------
Minimum Age: 16 Years
Maximum Age: 104 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: POC|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with high suPAR level | A high suPAR level, e.g. above 6 ng/ml | 24 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Q-CRP, lactate, suPAR, POC, ambulance
Evaluation of Prophylactic Heated Humidification on Obstructive Sleep Apnea (OSA) Patient Short Term Compliance to CPAP Therapy

Study Overview
=================
Brief Summary
-----------------
To compare two different clinical strategies in order to evaluate the impact of prophylactic heated humidification on OSA patients' compliance to CPAP therapy.

Detailed Description
-----------------
To compare two different clinical strategies in order to evaluate the impact of prophylactic heated humidification on OSA patients' compliance to CPAP therapy.

Official Title
-----------------
Humidifier Study: Evaluation of Prophylactic Heated Humidification on Obstructive Sleep Apnea (OSA) Patient Short Term Compliance to CPAP Therapy: Randomized Clinical Trial

Conditions
-----------------
Osa Syndrome

Intervention / Treatment
-----------------
* Device: heated humidification


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult Patient Newly diagnosed OSA Patients eligible to CPAP therapy Signed informed consent Exclusion Criteria: CPAP therapy contraindications Pregnancy Patient unable to come to study follow up visits or unable to finish the study. Informed consent not signed Adults who are subject to a legal protection measure or are unable to express their consent (such as patients under guardianship and patients deprived of judicial or administrative freedom)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: CPAP + Heated humidification<br>CPAP + Heated humidification | Device: heated humidification<br>* heated humidification system<br>|
| No Intervention: CPAP alone<br>CPAP | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CPAP mean usage (hours/night) at the 3 month follow up | therapy compliance | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sleep quality | pittsburgh sleep questionnaire index. total score | 3 months | 
| sleepiness | epworth sleep scale. total score | 3 months |
Music Therapy for Patients Being Weaned From Mechanical Ventilation

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to determine whether Music Therapy interventions can be used as supportive therapy for patients undergoing weaning from mechanical ventilation. The music will support the procedure by serving as a stimulus for relaxation and/or pain and anxiety management.Music used is varied according to subject's preferences.

Detailed Description
-----------------
Music therapy interventions will be used as supportive therapy for patients undergoing weaning from mechanical ventilation. The music will support the procedure by serving as a stimulus for relaxation and/or pain and anxiety management. The intervention will consist of 40 - 50 minutes of active music therapy and improvisation in which the music is used as a distraction from the hospital setting and the procedure taking place. The intervention will end with 5 to 10 minutes of discussion of music activities/selections to be used between music therapy sessions. The intervention is individualized and can be modified accordingly to the subject's preferences.

Official Title
-----------------
Music Therapy as an Adjunctive Treatment in the Management of Stress for Patients Being Weaned From Mechanical Ventilation

Conditions
-----------------
Respiratory Insufficiency

Intervention / Treatment
-----------------
* Behavioral: Music Therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Anxiety weaning sessions less than 8 hours Exclusion Criteria: weaning trials greater than 8 hours -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Music Therapy|Music Therapy|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluate the efficacy of music therapy interventions in assisting patient to be liberated from mechanical ventilation more quickly than control subjects. |  | prospective | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Exploratory hypotheses will investigate decreased anxiety measured by -physiologic measures |  | prospective | 
| - decreased use of anxiolytic, antidepressant and antipsychotic agents. |  | prospective | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Music Therapy, Mechanical ventilation, Weaning from mechanical ventilation, complementary and alternative therapy
Lymph Node Counts in Endometrial Cancer Staging

Study Overview
=================
Brief Summary
-----------------
The purposes of this study are to determine whether total lymph node count or the percentage of identified nodes with metastatic disease are influenced by (1) the method of categorizing tissue specimens or (2) the techniques of pathologic processing following lymphadenectomy. Patients with newly diagnosed endometrial carcinoma of high risk histologic type or uterine carcinosarcoma whose risk of LN metastasis exceeds 15% will be enrolled on this study. Patients will undergo staging to include hysterectomy and selective lymphadenectomy as per the clinical judgment of the primary Gynecologic Oncologist. Type of hysterectomy and the extent and distribution of lymphadenectomy is at the discretion of the surgeon. All patients will be scheduled for surgical staging. Each subject will have lymph nodes harvested on one side divided into specific basins, and on the contralateral side classified only as pelvic or aortic. Surgical node specimens in the operating room will be labeled by (1) specific nodal basins on the randomly determined side as external iliac, obturator, common iliac, aortic, or high aortic and by (2) pelvic versus aortic (common iliac nodes will be considered as part of the pelvic specimen) on the contralateral side.

Official Title
-----------------
A Prospective Study of the Impact of Surgical and Pathologic Tissue Sampling Methods on Lymph Node Counts and Detection of Lymph Node Metastasis in Endometrial Cancer Staging

Conditions
-----------------
Endometrial Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Uterine cancer with one of the following pathologies: serous, clear cell, sarcoma or grade 3 differentiation surgical candidate Exclusion Criteria: -
Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total gross node identification |  | 0-14 days post op | 
| Percentage of lymph nodes showing metastatic cancer (%NM) |  | 0-14 days post op |
Cognitive-behavioral Weight Loss Treatment

Study Overview
=================
Brief Summary
-----------------
That a treatment using a cognitive-behavioral treatment for exercise and nutrition support will be associated with greater weight loss that a treatment of nutrition and exercise education.

Official Title
-----------------
Effects of a Cognitive-behavioral Weight Loss Treatment

Conditions
-----------------
Weight

Intervention / Treatment
-----------------
* Behavioral: cognitive behavioral exercise and nutrition over
* Behavioral: nutrition and exercise education


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Female Ages 21-60 Body mass index 30-40 kg/m2 Exclusion Criteria: Pregnancy Medications for a psychological disorder Contraindications for exercise

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cognitive-behavioral<br>Those participating in a cognitive behaviorally supported exercise and nutrition treatment will receive a cognitive behavioral exercise and nutrition over 50 weeks | Behavioral: cognitive behavioral exercise and nutrition over<br> <br> |
| Active Comparator: Nurtition education<br>This arm will participate in nutrition and exercise education | Behavioral: nutrition and exercise education<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| weight | Direct measurement of weight | baseline, months 3,6,12, 24 |
Pain After Stroke, Part 2: Clinical Characteristics and Classification of Pain in Patients After Stroke

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to investigate the prevalence of characteristics of pain in a cohort of patients with prior stroke suspected of having central post stroke pain, identified through a postal questionnaire.

Detailed Description
-----------------
Medical history, pain history, pain drawing, DN4, sensory examination.

Official Title
-----------------
Pain After Stroke, Part 2: Clinical Characteristics and Classification of Pain in Patients After Stroke

Conditions
-----------------
Pain

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Possible neuropathic pain following stroke Exclusion Criteria: Severe dementia Severe language barriers Patients who cannot cooperate
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Central Neuropathic Pain, Central Post-Stroke Pain, Stroke, Pain
Lumbar Disc Space Height in Young Disc Herniation and Degeneration Patients

Study Overview
=================
Brief Summary
-----------------
As low back pain (LBP) imposes a heavy socioeconomic burden, early detection of pathologic intervertebral disc change in young adults holds high clinical relevance as a common structural cause of LBP. The investigators therefore assessed the feasibility of using X-ray disc space height measurements as a predictive evaluation method of lumbar disc herniation (LDH) and degeneration in LBP patients in their early 20s.

Official Title
-----------------
Lumbar Intervertebral Disc Space Height in Disc Herniation and Degeneration Patients in Their Early 20s

Conditions
-----------------
Intervertebral Disc Displacement, Intervertebral Disc Degeneration, Low Back Pain

Intervention / Treatment
-----------------
* Radiation: x-ray, MRI


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 20-25 years L-spine X-ray and L-spine MRIs taken within a week of the other test Native Korean ethnicity Exclusion Criteria: Scoliosis with a Cobb's angle of ≥20° Significant vertebral deformity of any etiology (e.g. spondylolisthesis, fracture, spondylitis, neoplasm) Previous spinal surgery

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 25 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| The experimental group<br>Patients with intervertebral disc protrusion, extrusion, or migration at L4/5 randomly selected from a population pool of 665 patients with L-spine X-ray and L-spine MRIs taken within a week of the other test. | Radiation: x-ray, MRI<br> <br> |
| The control group<br>Patients with normal or disc bulging readings at L4/5 randomly selected from a population pool of 665 patients with L-spine X-ray and L-spine MRIs taken within a week of the other test. | Radiation: x-ray, MRI<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The distance between the 2 midpoints of the inferior and superior borders of the vertebral bodies surrounding the L4/5 intervertebral disc space divided by the AP diameter of the inferior border of the L4 vertebral body |  | Baseline | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
X-Rays, Magnetic Resonance Imaging, Sensitivity and Specificity