Assessment of Lung Movement With Computed Tomography (CT)

Study Overview
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Brief Summary
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The purpose of this study is to determine whether patient with ILD have altered lung compliance on chest CT before they have macroscopic structural changes on CT.

Detailed Description
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Interstitial lung disease (ILD) is a group of lung disorders in which the lung tissues become inflamed and then damaged. Idiopathic Pulmonary Fibrosis (IPF) is one of the subtypes of ILD which has characteristic histological and CT features. It is well known that microscopic fibrosis occurs in the lungs of IPF patients well before the structural changes of fibrosis become apparent on CT. By combining sophisticated image analysis with CT scans obtained at full inspiration and full expiration, it may be possible to detect earlier changes of IPF than currently possible by looking at macro structural features alone. With the recent development of new therapeutics for IPF, early detection of the disease and improved monitoring of treatment efficacy will become important. Using CT to assess regional lung compliance has the potential to become an easily translated clinical tool.

Official Title
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Assessment of Lung Movement With CT in Healthy Subjects and Patients With ILD

Conditions
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Interstitial Lung Disease

Intervention / Treatment
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* Device: Chest CT
* Diagnostic Test: Pulmonary Function Testing


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects with ILD: Subjects must have a physician diagnosis of ILD and be in stable pulmonary condition at the time of the CT Healthy subjects: Subjects must have no history of pulmonary disease and smoked less than 100 cigarettes in their lifetime Exclusion Criteria: Subjects less than 18 years of age

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Interventional Model Description: All participants will undergo CT and pulmonary function testing.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Pulmonary Assessment<br>All participants will undergo a Chest CT scan and pulmonary function testing | Device: Chest CT<br>* Inspiration and expiration chest CT<br>Diagnostic Test: Pulmonary Function Testing<br>* Measure lung function<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lung Motion as Assessed by CT | A computer algorithm will compare the inspiration and expiration CT scans to determine regional lung motion. | Study visit 1 of a single visit study | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lung Motion: Lobar Strain Which is a Ratio | Lobar strain (S): the volumetric strain of each lobe i [i = Right Upper (RU), Right Lower (RL), Left Lower (LL), and Left Upper (LU)] as the difference in lobe volume between the expanded and contracted states, normalized by the lobe volume in the expanded state | Study visit 1 of a single visit study | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis