Slow-wave Sleep Deprivation in Depression

Study Overview
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Brief Summary
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Sleep deprivation can acutely reverse depressive symptoms in patients with major depression. Although underlying mechanisms of the antidepressant action in sleep deprivation are unclear, many of these observations can be explained by abnormal slow wave homeostasis. This study will test the prediction that selectively reducing slow waves during sleep (slow wave deprivation; SWD), without disrupting total sleep time, will yield an antidepressant effect.

Detailed Description
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see above

Official Title
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Slow-wave Sleep Deprivation as a Possible Treatment for Major Depressive Disorder

Conditions
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Major Depressive Disorder

Intervention / Treatment
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* Device: Slow-wave deprivation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Among the inclusion criteria will be: age range 18-35 years right handedness major depressive disorder according to DSM-IV (Diagnostic and Statical Manual-Revision 4) criteria (as determined by the Structured Clinical Interview for Diagnostic and Statical Manual-Revision 4), with Hamilton Rating Scale for *Depression scores of at least 18 on the first 17 items no psychotropic medications for at least 4 weeks no joint and muscular di normal hearing regular bedtimes and sleep duration, no time zone shifts in the last three weeks. Exclusion Criteria: Diabetes requiring insulin treatment A serious heart disorder or subjects who have had a heart attack within the last 3 months A diagnosis of cancer in the past 3 years and/or has active neoplastic disease Clinically significant abnormalities on pre-study physical exam or physician evaluation Subjects who meet DSM-IV (Diagnostic and Statical Manual-Revision 4) criteria for alcohol/drug abuse problems within the last six months or are currently using illegal drugs. Female subjects of child-bearing potential who are pregnant or planning to become pregnant. Women of child-bearing must be practicing a medically acceptable form of birth control. Women of childbearing potential will be questioned about pregnancy status and form of birth control to be used at each visit. Women who are unsure of their pregnancy status will be given a urine pregnancy test. Subjects taking investigational medications Subjects currently undergoing electroconvulsive therapy (ECT) or therapeutic transcranial magnetic stimulation (TMS). Subjects who regularly perform night or late evening shift work (e.g. - second or third shifts) or have had travel with time zone shifts >3h in the last 3 weeks

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Sleep deprivation<br>Slow-wave sleep deprivation for one night as an experimental treatment for major depressive disorder | Device: Slow-wave deprivation<br>* Using acoustic tones to suppress slow-wave sleep<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hamilton Depression Scale |  | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Inventory of Depressive Symptomology | rating scale of mood | 24 hours |