Lung Diffusing Capacity for Nitric Oxide During Cycling Exercise

Study Overview
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Brief Summary
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This study investigates the test-retest reliability of the lung diffusing capacity for nitric oxide in healthy individuals during exercise.

Detailed Description
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The aim of this study of to evaluate the test-retest reliability of single-breath lung diffusing capacity measurements for nitric oxide (DLNO) in healthy individuals during light and moderate intensity cycling exercise. Healthy subjects will perform repeated single-breath DLNO measurements during light (i.e., at 50% of the first ventilatory threshold) and moderate intensity exercise (i.e., 80% of the first ventilatory threshold) on a stationary cycle ergometer.

Official Title
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Test-retest Reliability of Lung Diffusing Capacity for Nitric Oxide During Light and Moderate Intensity Cycling Exercise

Conditions
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Healthy

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy Age 18 yrs and older Ability to follow study procedures and instructions in German Exclusion Criteria: Any known cardiopulmonary or metabolic diseases (e.g., heart disease, diabetes mellitus etc) Obesity (BMI > 30kg/m2) Smoking (ex-smoker allowed; if they stopped smoking at least one year before the examination) Mental impairment leading to inability to cooperate Respiratory infection in the last two weeks Forced expiratory volume in 1s/ forced vital capacity (FEV1/FVC ratio) FEV1/FVC ratio < lower limit of normal according to equations by Quanjer et al. Eur Respir J 2012.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diffusing capacity for nitric oxide (DLNO) | DLNO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise. | At second study visit | 
| Diffusing capacity for nitric oxide (DLNO) | DLNO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise. | At third study visit, approximately 1-2 weeks after second study visit | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diffusing capacity for nitric oxide (DLNO) | DLNO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise. | At second study visit | 
| Diffusing capacity for nitric oxide (DLNO) | DLNO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise. | At third study visit, approximately 1-2 weeks after second study visit | 
| Diffusing capacity for carbon monoxide (DLCO) | DLCO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise. | At second study visit | 
| Diffusing capacity for carbon monoxide (DLCO) | DLCO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise. | At third study visit, approximately 1-2 weeks after second study visit | 
| Diffusing capacity for carbon monoxide (DLCO) | Agreement in DLCO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise. | At second study visit | 
| Diffusing capacity for carbon monoxide (DLCO) | Agreement in DLCO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise. | At third study visit, approximately 1-2 weeks after second study visit | 
| Alveolar volume (VA) | VA (in L) measured at 50% of the gas exchange threshold during cycling exercise. | At second study visit | 
| Alveolar volume (VA) | VA (in L) measured at 50% of the gas exchange threshold during cycling exercise. | At third study visit, approximately 1-2 weeks after second study visit | 
| Alveolar volume (VA) | Alveolar volume (in L) measured at 80% of the gas exchange threshold during cycling exercise. | At second study visit | 
| Alveolar volume (VA) | Alveolar volume (in L) measured at 80% of the gas exchange threshold during cycling exercise. | At third study visit, approximately 1-2 weeks after second study visit | 
| Breath hold time (BHT) | BHT (in s) measured at 80% of the gas exchange threshold during cycling exercise. | At second study visit | 
| Breath hold time (BHT) | BHT (in s) measured at 80% of the gas exchange threshold during cycling exercise. | At third study visit, approximately 1-2 weeks after second study visit | 
| Breath hold time (BHT) | BHT (in s) measured at 50% of the gas exchange threshold during cycling exercise. | At second study visit | 
| Breath hold time (BHT) | BHT (in s) measured at 50% of the gas exchange threshold during cycling exercise. | At third study visit, approximately 1-2 weeks after second study visit | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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lung diffusing capacity for nitric oxide, lung function testing