The Effects of Early Enteral Nutrition on Endoscopic Therapy of Esophagogastric Varices in Liver Cirrhosis

Study Overview
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Brief Summary
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The purpose of this study was to evaluate the safety of early enteral nutrition on endoscopic therapy of esophagogastric varices in Liver Cirrhosis ,and to assess the impact of different eating times on patients, so as to determine the best time for patients to obtain nutrition after surgery.

Detailed Description
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For patients with gastroesophageal varices in Liver Cirrhosis,, there is no clear guideline and consensus on when to start eating after endoscopic treatment. In 2015, a randomized controlled study in Taiwan of China confirmed that compared with liquid diet given 48 h after endoscopic treatment, liquid diet given 4 h and started enteral nutrition would not increase the risk of rebleeding, and could improve the nutritional status of patients. However, some patients after endoscopic treatment would suffer from post-sternal pain, abdominal pain, nausea, vomiting and other discomforts, affecting appetite and delay the diet time. Based on the above research background, we observed and evaluated the safety and effectiveness of early enteral nutrition in patients with cirrhotic esophageal and gastric varices after endoscopic treatment, and analyzed the influencing factors of enteral nutrition in patients with cirrhotic esophageal and gastric varices after endoscopic treatment, so as to further clarify the optimal time for patients to eat after endoscopic treatment.

Official Title
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Investigation of the Effects of Early Enteral Nutrition on Endoscopic Therapy of Esophagogastric Varices in Liver Cirrhosis:An Observational Study

Conditions
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Liver Cirrhosis, Esophageal and Gastric Varices

Intervention / Treatment
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* Dietary Supplement: nutrient solution


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with cirrhosis of gastroesophageal varices undergoing endoscopic therapy Exclusion Criteria: Endoscopic treatment of uncontrollable bleeding Accompanied with other endoscopic treatments that need to be fasting With obvious hepatic encephalopathy and liver failure Did not sign the informed consent form and refused to participate

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| early enteral nutrition support group<br>Nutrient solution is provided through oral nutrient solution within 4-48 hours after endoscopic treatment | Dietary Supplement: nutrient solution<br>* For the patients with esophageal and gastric varices after endoscopic treatment，start taking the nutrient solution at the fourth hour.<br>|
| parenteral Nutrition Group<br>Intravenous nutrition is provided within 48 hours after endoscopic treatment | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rebleeding | the rate of rebleeding after endoscopic therapy | 2 to 30days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Early enteral nutrition, Esophageal and Gastric Varices, Rebleeding