Computerized Anxiety Treatment for Suicide

Study Overview
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Brief Summary
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The purpose of this study is to test the effectiveness and usability of multiple computer-based treatments for mood and anxiety relevant risk factors. The target of the treatment is related to cognitive stress, which has been shown to be associated with a variety of negative mental health outcomes such as Post-Traumatic Stress Disorder, suicidal ideation, and substance use disorders.

Detailed Description
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CATS is a newly developed computerized treatment targeting specific risk factors associated with anxiety symptoms and suicidal thoughts. Individuals will be asked to complete four appointments, where they will complete various self-report questionnaires as well as a newly developed computerized treatment targeting risk factors associated with anxiety.

Official Title
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Suicide Risk Prevention Among Patients With Anxiety Psychopathology

Conditions
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Anxiety, Suicide

Intervention / Treatment
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* Other: Cognitive Anxiety Sensitivity Treatment
* Other: Physical Health Education Training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Meet diagnostic criteria for a primary Axis 1 anxiety disorder or meet diagnostic criteria for a unipolar mood disorder along with an Axis 1 anxiety disorder. Show evidence of current suicidal ideation (BSS above 6. Show elevated AS indicated by scoring at or above the community sample mean on the ASI-Cog (above 9. Exclusion Criteria: No significant medical illness (e.g. sig cardiovascular disease, epilepsy, stroke). Current or past psychotic-spectrum disorders or uncontrolled bipolar disorder No current substance dependence Must be an English speaker. Must be 18 years or older. Must have normal or corrected vision Cannot begin treatment/therapy within 1 month of baseline. Cannot begin a new medication within 3 months of baseline.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention<br>The anxiety risk reduction condition will be a combination of psychoeducation plus Cognitive Bias Modification (CBM-I) for anxiety sensitivity (AS). The psychoeducational component will focus on the nature of stress and its effect on the body. Interoceptive exposure (IE) exercises, designed to correct the conditioned fear to these bodily sensations, will be explained and practiced. | Other: Cognitive Anxiety Sensitivity Treatment<br> <br> * Other names: Computerized Anxiety Treatment for Suicide (CATS);|
| Placebo Comparator: Control<br>The control condition will be a combination of information about general health and wellness (e.g. diet, exercise etc.) plus an inert Cognitive Bias Modification (CBM-I) task. | Other: Physical Health Education Training<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anxiety Sensitivity Index-3 (ASI-3) | The ASI-3 is an 18-item self-report measure of anxiety sensitivity (AS). This scale was developed to provide a more stable measure of the three most widely recognized AS subfactors (cognitive, social and physical concerns) than the original ASI provides. Each subfactor is represented by six items. The measure has shown good psychometric properties. | Month 4 follow-up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Beck Suicide Scale (BSS) | The BSS is a 21-item widely used self-report measure assessing a broad spectrum of behaviors and attitudes related to suicide risk, including suicidal ideation and past suicide attempts. It has demonstrated strong reliability and validity. | Month 4 follow-up | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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computerized intervention, cognitive bias modification, anxiety, suicide