Acute MRI in Transient Ischemic Attack

Study Overview
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Brief Summary
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The purpose of this study is to detect acute ischemic lesions in patients admitted with symptoms of transient ischemic attack (TIA). Diffusion weighted Imaging (DWI) is today one of the best ways to detect ischemic lesions after TIA. The problem is that this only gives the diagnosis in 30% of the cases. It is possible that the addition of Arterial spin labeling (ASL) perfusion imaging and diffusion tensor imaging will make it possible to give a more accurate diagnosis.

Detailed Description
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The purpose of this study is to detect acute ischemic lesions in patients admitted with symptoms of transient ischemic attack (TIA). Diffusion weighted Imaging (DWI) is today one of the best ways to detect ischemic lesions after TIA. The problem is that this only gives the diagnosis in 30% of the cases. It is possible that the addition of ASL-perfusion imaging and diffusion tensor imaging will make it possible to give a more accurate and selective diagnosis of TIA. Patients admitted with clinical signs of TIA can be included. Patients will be examined with the TIA protocol in reference to the standardized clinical care: 1,5 tesla gradient echo and 3 tesla Susceptibility weighted imaging (SWI) to detect microbleed as sign of small vessel disease. Axial T2 FLAIR to detect white matter lesions. Axial DWI to detect areas with impeded diffusion. (Total scantime 10min) If no signs of ischemic lesions is detected the following additional research scan-protocol will be initiated: Perfusion without contrast: Arterial spin labeling (ASL) with the ability of showing signs of ischemia. Diffusion tensor imaging (DTI): Has a higher sensitivity than DWI in displaying local ischemic lesions. (Total additional scantime 10min) All in All 20min in the scanner.

Official Title
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Acute MRI-techniques for the Detection of Ischemic Lesions After Transient Ischemic Attack

Conditions
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Ischemic Attack, Transient

Intervention / Treatment
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* Procedure: MRI Scan


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical signs of TIA Informed consent No serious respiratory or cardiac implications Exclusion Criteria: Contraindications to MRI

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: MRI Scan|Patients will have to spend additional 10min in the scanner. Additional scan modalities used: Perfusion without contrast: Arterial spin labeling (ASL) with the ability of showing signs of ischemia. Diffusion tensor imaging (DTI): Has a higher sensitivity than DWI in displaying local ischemic lesions. An overall 20min scan period.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| frequency of patients with ischaemic lessions on DTI | We want to assess the frequency of patients in whom a diffusion restricted lesion can only be observed on DTI | on first MRI | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Diffusion Tensor Imaging