Outcome After Avascular Necrosis of the Femoral Head in Young Patients

Study Overview
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Brief Summary
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The course of AVN between Initial diagnosis and total hip replacement (THA) is analysed. The impact of early interventions versus conservative therapy in AVN before THA will be evaluated. The short and long term outcomes of AVN patients undergoing THA with respect to complications, reoperations and quality of life are investigated. Potential risk factors for adverse outcomes will be investigated.

Detailed Description
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The study is to describe the course of avascular necrosis (AVN) of the femoral head from initial diagnosis and to collect data on treatment options and the further course in these cases. The duration from initial diagnosis of AVN to joint replacement as total hip arthroplasty (THA) will be analysed and the course after joint replacement with potential short- and long-term complications will be evaluated. The impact of THA after AVN on activities of daily living will be assessed by Euroquol 5 Dimensions (EQ-5D-5L) and Hip disability and Osteoarthritis Outcome Score (HOOS) questionnaires.

Official Title
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Outcome After Avascular Necrosis of the Femoral Head in Young Patients - Retrospective Analysis With a Min. 10-year Follow-up

Conditions
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Avascular Necrosis of the Femoral Head

Intervention / Treatment
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* Other: questionnaires for patient reported outcome
* Other: questionnaire for course of the disease


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: MRI of the hip available from diagnosis at the USB or KSBL Liestal Informed Consent Exclusion Criteria: Insufficient knowledge of project languages (English, German, French)
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Population 1<br>Patients with a first AVN-related contact (initial or confirmed diagnosis) at the Universitätsspital Basel (USB) or Kantonsspital Basel-Liestal (KSBL) in the years between 1999-2006 (being assessed by questionnaires for patient reported outcome and questionnaire for course of the disease) | Other: questionnaires for patient reported outcome<br>* questionnaires with respect to outcomes: Reoperations Short term complications Long term complications EQ-5D (current) HOOS (current) disease related change of occupation use of walking aids comorbidities medication<br>Other: questionnaire for course of the disease<br>* questionnaires to assess course of the disease: from initial diagnosis of AVN to joint replacement as total hip arthroplasty (THA) therapeutic interventions<br>|
| Population 2<br>Patients with a THA because of AVN in the years 2000-2007 (being assessed by questionnaires for patient reported outcome and questionnaire for course of the disease) | Other: questionnaires for patient reported outcome<br>* questionnaires with respect to outcomes: Reoperations Short term complications Long term complications EQ-5D (current) HOOS (current) disease related change of occupation use of walking aids comorbidities medication<br>Other: questionnaire for course of the disease<br>* questionnaires to assess course of the disease: from initial diagnosis of AVN to joint replacement as total hip arthroplasty (THA) therapeutic interventions<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| arthroplasty-free interval (time until THA) | time from first diagnosis of AVN to joint replacement = time to event data (in the years between 1999-2006) | single time point assessment at baseline | 
| rate of reoperations after THA | reoperation after THA = time to event data (in the years between 2000-2007) | single time point assessment at baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hip disability and Osteoarthritis Outcome Score (HOOS) | 40 item questionnaire to assess patient-relevant outcomes in five separate subscales (pain, symptoms, activity of daily living, sport and recreation function and hip related quality of life). Scores are: None, Mild, Moderate, Severe, Extreme | single time point assessment at baseline | 
| Euroquol 5 Dimensions (EQ-5D-5L) | Five dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. Each dimension has 5 levels: no problems, slight problems, moderate problems, severe problems and extreme problems. | single time point assessment at baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Total hip arthroplasty, Total hip replacement