Early Intervention for Impairments Identified During Comprehensive Geriatric Assessment in Patients With Bladder Cancer

Study Overview
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Brief Summary
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A Comprehensive Geriatric Assessment (CGA) is a set of tests used to evaluate a patient's medical, social, and functional status, and can identify impairments in these domains that may not be noticed otherwise. Prior studies have shown that a CGA can accurately predict which patients are more likely to have serious side effects from cancer treatment. However, it is unknown whether interventions can be done to address the impairments found during a CGA in order to reduce the risk of these side effects. This pilot study will test the feasibility of targeted interventions for deficits identified during a CGA in patients 65 years or older with bladder cancer that have not yet started treatment.

Detailed Description
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This study will enroll patients with muscle-invasive bladder cancer that have not yet started systemic cancer treatment. The participants will complete a CGA and patient-reported outcome (PRO) measures at baseline. Based on any impairments found during the CGA, participants will be referred to specialists to help address these difficulties. Participants will complete the CGA and PRO measures again at 3 months and 1 year after the initial assessment. The goal of this study is to see if patients with advanced bladder cancer are interested in referrals to specialists to address their impairments, and whether participants attend those appointments.

Official Title
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A Pilot Study of Early Intervention for Impairments Identified During Comprehensive Geriatric Assessment in Patients With Muscle-invasive Bladder Cancer

Conditions
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Bladder Cancer

Intervention / Treatment
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* Other: Targeted Interventions for Impairments Identified During Geriatric Assessment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 65 years or older Confirmed diagnosis of muscle-invasive bladder cancer Plan to undergo systemic treatment but have not yet started therapy Exclusion Criteria: Must be able to read English

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Geriatric assessment guided interventions<br> | Other: Targeted Interventions for Impairments Identified During Geriatric Assessment<br>* Participants will be referred for specific evidence-based interventions based on impairments identified during a baseline comprehensive geriatric assessment.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient interest in impairment-directed interventions | To establish patient interest in referral for interventions based on impairments found during geriatric assessment within an outpatient genitourinary oncology clinic. Success will be at least 75% of patients accepting referral for indicated interventions. | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Geriatric oncology, Comprehensive geriatric assessment, Patient-reported outcomes, Muscle-invasive bladder cancer