Assessment of Response to the Conventional Periodontal Treatment Based on the Blood Group Phenotypes.

Study Overview
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Brief Summary
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The aim of this study is to find out if one blood group phenotype is more responsive than the others to the nonsurgical periodontal treatment.

Detailed Description
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To the best of our knowledge, this is the first (research) randomized clinical trial that assesses how patient respond to the nonsurgical periodontal treatment based on their blood group phenotype.

Official Title
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Investigating the Role of ABO Blood Group in the Response to the Nonsurgical Periodontal Treatment.

Conditions
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Chronic Periodontitis

Intervention / Treatment
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* Procedure: nonsurgical periodontal treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: systematically healthy. have at least 20 teeth excluding the third molars. had not received any periodontal treatment or antibiotic therapy for dental or medical reason 6 month prior to the study. diagnosed with generalized chronic periodontitis (>30% of the sites have probing depth ≥4), and a minimum of six teeth with probing depth of 5-6 mm. Exclusion Criteria: smokers and alcoholics. pregnancy. history of a systematic disease such as diabetes, leukemia, epilepsy. participants who are unable to perform routine oral hygiene. use of orthodontic appliances. participants who are unable to perform routine oral hygiene.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients whose blood type is A<br>Applying nonsurgical periodontal treatment (scaling and root planning). | Procedure: nonsurgical periodontal treatment<br>* patients will undergo nonsurgical periodontal treatment to reduce the relative attachment level and improve the probing depth. An initial session will be conducted to remove supra gingival plaque and calculus. another appointment is set to perform full moth scalling and root planing.<br>* Other names: scalling and root planing;|
| Patients whose blood type is B<br>Applying nonsurgical periodontal treatment (scaling and root planning). | Procedure: nonsurgical periodontal treatment<br>* patients will undergo nonsurgical periodontal treatment to reduce the relative attachment level and improve the probing depth. An initial session will be conducted to remove supra gingival plaque and calculus. another appointment is set to perform full moth scalling and root planing.<br>* Other names: scalling and root planing;|
| Patients whose blood type is AB<br>Applying nonsurgical periodontal treatment (scaling and root planning). | Procedure: nonsurgical periodontal treatment<br>* patients will undergo nonsurgical periodontal treatment to reduce the relative attachment level and improve the probing depth. An initial session will be conducted to remove supra gingival plaque and calculus. another appointment is set to perform full moth scalling and root planing.<br>* Other names: scalling and root planing;|
| Patients whose blood type is O<br>Applying nonsurgical periodontal treatment (scaling and root planning). | Procedure: nonsurgical periodontal treatment<br>* patients will undergo nonsurgical periodontal treatment to reduce the relative attachment level and improve the probing depth. An initial session will be conducted to remove supra gingival plaque and calculus. another appointment is set to perform full moth scalling and root planing.<br>* Other names: scalling and root planing;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in relative attachment level. | the relative attachment level measures the length form the base of the periodontal pocket to a stent | measures will be taken at baseline and after two months from treatment. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in periodontal probing depth. | the distance between the gingival margin to the base of the periodontal pocket. | measures will be taken at baseline and after two months from treatment. | 
| Change in gingival index | it is used to designate the level of the gingival inflammation. | index will be taken at baseline and after two months from treatment. | 
| Change in plaque Index | it is used to designate the level of plaque accumulation. | index will be taken at baseline and after two months from treatment. |