The Correlation Between the Metabolism and the Functional Status of Multiple Organs in the Early Stage of Diquat Poisoning

Study Overview
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Brief Summary
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Diquat (DQ), as a conductive biocidal herbicide, is classified as medium according to Chinese pesticide toxicity classification standards. Since the sale and use of paraquat are stopped in 2016, incidents of diquat poisoning have begun to increase. Diquat is very toxic to the human body. Mistake of Diquat can cause damage to multiple organs throughout the body. It has a high fatality rate and no specific treatment.The treatment method has become a research hotspot of modern poisoning treatment. The degree of organ dysfunction caused by DQ poisoning is mainly related to the patient's intake and the distribution of the poison in the human body.So far, the distribution concentration of DQ under the influence of the time gradient in the body and the influence of DQ on the human environment，metabolimics,，immune regulation activity and the comprehensive mechanism of action of various inflammatory factors have not been fully elucidated. Therefore, this research mainly focuses on analyzing the internal environment metabolism research in patients with DQ poisoning, and to conduct exploratory research on the severity of the impact on their organ functions

Official Title
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The Correlation Between the Metabolism and the Functional Status of Multiple Organs in the Early Stage of Diquat Poisoning---A Multicenter Observational Study

Conditions
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Diquat Poisoning

Intervention / Treatment
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* Diagnostic Test: Detect the serum sample


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1.Time from poisoning to hospital admission: within 6 hours, 2 The age is greater than 18 years old, less than 65 years old 3 There is at least one target organ dysfunction 4 Previous physical fitness 5 No bad habits (drug use, alcohol addiction) Exclusion Criteria: Refuse to join this study Missing/incomplete information Pregnant women, vulnerable groups such as those who have no capacity for civil conduct and cannot determine the consent of their attorneys Chronic organ dysfunction (chronic heart insufficiency, chronic respiratory insufficiency, chronic renal insufficiency, chronic Liver insufficiency) Tumors, blood system diseases, various systemic immune diseases Various infectious diseases (various hepatitis, tuberculosis, AIDS)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients of Diquat poisoning<br> | Diagnostic Test: Detect the serum sample<br>* Detect the serum sample<br>|
| normal persons<br> | Diagnostic Test: Detect the serum sample<br>* Detect the serum sample<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The poison metabolomics of Diquat | Improve the correlation between the concentration and metabolism rate of diquat poisoning in vivo and metabolomics and the co-damage color of body organs for bioinformatics analysis and summary | 2022-06 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Diquat Metabolomics Toxicology Multicenter