Effect of Prone Positioning in Patients With COVID-19

Study Overview
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Brief Summary
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COVID-19 is affecting the people around the world and the infected individuals' may either stay asymptomatic or present to hospitals with severe distress and life threatening symptoms. The objective of the study is to investigate role of Prone positioning and alternate nostril breathing in patients with Covid-19.

Detailed Description
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In this prospective study, 30 patients aged 40-80 years of either gender with a confirmed diagnosis of COVID-19 receiving supplemental oxygen were recruited from DHQ Hospital Faisalabad. patients were grouped into two A & B. We collected baseline data on demographics and anthropometrics. After baseline data collection, all the patients were helped into the prone position, which was maintained for a minimum duration of three hours. After that patients in group B performed alternate nostril breathing for 10 minutes with help of therapist. Clinical data were re-collected on 3rd day of intervention one hour after returning to the supine position in group A and after alternate nostril breathing in group B. The main study outcome was the variation in oxygenation (partial pressure of oxygen [PaO2]/ fractional concentration of oxygen in inspired air [FiO2]) between baseline and resupination, and General psychological state through GAD-7 General anxiety disorder questionnaire.

Official Title
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Effect of Prone Positioning and Alternate Nostril Breathing Technique in Patients With COVID-19: A Prospective Cohort Study.

Conditions
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Covid19

Intervention / Treatment
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* Other: Prone Lying Position
* Other: alternate nostril breathing


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age: 40-80 Gender: Both GCS score:15 Exclusion Criteria: COPD Intubated ARDS Smoker Neurological Disorder

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group-A<br>Patient performed prone lying position for three hours. | Other: Prone Lying Position<br>* patient lies on his/ her stomach facing floor.<br>* Other names: Positioning;|
| Group-B<br>along with Prone lying position, patients also performed alternate nostril breathing for ten minutes. | Other: Prone Lying Position<br>* patient lies on his/ her stomach facing floor.<br>* Other names: Positioning;Other: alternate nostril breathing<br>* patient inspires with one nostril at a time, right or left one by one and expires by mouth.<br>* Other names: breathing technique;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PaO2 | partial pressure of oxygen. | Change in score before the intervention on 1st day of intervention and on 3rd day one hour after the intervention. | 
| FiO2 | Fractional concentration of oxygen in inspired air [FiO2]) | Change in score before the intervention on 1st day of intervention and on 3rd day one hour after the intervention. | 
| General Anxiety Disorder-7 Score | general anxiety disorder-7 score ranges from 0-21, out of which 0-4 means minimal anxiety, 5-9 stands for mild anxiety, 10-14 for moderate and 15-21 for severe anxiety. | Change in score before the intervention on 1st day of intervention and on 3rd day one hour after the intervention. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Covid-19, General Anxiety Disorder-7, Prone Position, Alternate Nostril Breathing