Status Epilepticus in the Critically Ill Patients

Study Overview
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Brief Summary
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Convulsive and Non Convulsive Status Epilepticus (SE) and Pseudo Status Epilepticus prospective registry. Data collection using a standardized form : demographic data and data related to the SE, including circumstances of onset, dates and times of onset and of seizure control, on-scene clinical findings, clinical features of the seizures, pre-hospital and hospital care providers, timing of antiepileptic and supportive treatments, results of etiological investigations, cause of SE, type and dosage of antiepileptic drugs. Dates and times of EEG monitoring, EEG results. Outcomes including vital status and Glasgow Outcome Scale score at ICU and hospital discharge, day-90 and 1-year after SE and determined based on data in the ICU and/or neurologist charts and/or patients phone interview.

Official Title
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Status Epilepticus in the Critically Ill Patients

Conditions
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Status Epilepticus

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: SE defined as 5 min or more of (i) continuous clinical and/or electrographic seizure activity or (ii) recurrent seizure activity without recovery (returning to baseline) between seizures. age >= 18 years Exclusion Criteria: age < 18 years postanoxic status epilepticus

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Status Epilepticus<br>Convulsive and Non-Convulsive Status Epilepticus ; and Pseudo Status Epilepticus | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Favorable outcome | A favorable outcome is defined by a Glasgow Outcome Scale (GOS) of 5. The Glasgow Outcome Scale (GOS) will be determined according to patients charts review and/or general practitioner interview conducted by an independent assessor. The GOS score : [1: Death, 2: Persistent vegetative state, 3: Severe disability, 4: Moderate disability, 5 : Low disability] | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Favorable outcome | A favorable outcome is defined by a Glasgow Outcome Scale (GOS) of 5. The Glasgow Outcome Scale (GOS) will be determined patients charts review and/or general practitioner interview conducted by an independent assessor. The GOS score : [1: Death, 2: Persistent vegetative state, 3: Severe disability, 4: Moderate disability, 5 : Low disability] | 3 months, 5-years and 10 years | 
| Functional impairment | Percentages of the patients that experience functional impairment (motor, sensitive, cognitive, epilepsy) | 3 months, and 1-year, 5-years and 10-years | 
| total seizure duration | total seizure duration in minutes | 72 hours | 
| percentages of the patients that experience recurrent convulsive and/or non-convulsive seizures within 12 hours after ICU admission |  | 12 hours | 
| refractory status epilepticus |  | 24 hours | 
| super refractory status epilepticus |  | 72 hours | 
| total ICU and in-hospital length of stay | total ICU and in-hospital length of stay in days | 90 days | 
| mortality rate |  | ICU and hospital discharge, 3-months, and 1-year, 5 years and 10 years |