MS Mosaic: A Longitudinal Research Study on Multiple Sclerosis

Study Overview
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Brief Summary
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The purpose of this study is to better characterize the fluctuations in multiple sclerosis symptoms and their relationship to medications, to length/extent of disease, and to a variety of physiologic measures.

Official Title
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MS Mosaic: A Longitudinal Research Study on Multiple Sclerosis

Conditions
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Multiple Sclerosis

Intervention / Treatment
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* Other: Personal history of multiple sclerosis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Be at least 18 years old Live in the United States of America Read/write in English Exclusion Criteria: None

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Relapsing Remitting Multiple Sclerosis<br>Those who document during the study on-boarding process that they suffer from relapsing-remitting multiple sclerosis. | Other: Personal history of multiple sclerosis<br>* Participants will be stratified into one of four cohorts based on their experience (or lack of experience) with the three major forms of multiple sclerosis.<br>|
| Primary Progressive Multiple Sclerosis<br>This who document during the on-boarding process that they suffer from primary progressive multiple sclerosis. | Other: Personal history of multiple sclerosis<br>* Participants will be stratified into one of four cohorts based on their experience (or lack of experience) with the three major forms of multiple sclerosis.<br>|
| Secondary Progressive Multiple Sclerosis<br>This who document during the on-boarding process that they suffer from secondary progressive multiple sclerosis. | Other: Personal history of multiple sclerosis<br>* Participants will be stratified into one of four cohorts based on their experience (or lack of experience) with the three major forms of multiple sclerosis.<br>|
| Control<br>This who document during the on-boarding process that they do not suffer from multiple sclerosis. | Other: Personal history of multiple sclerosis<br>* Participants will be stratified into one of four cohorts based on their experience (or lack of experience) with the three major forms of multiple sclerosis.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in perceived fatigue severity (self-report) as recorded by symptom diary |  | Every 24 hours through study completion, an average of 6 months | 
| Change in perceived cognitive impairment (self-report) as recorded by symptom diary | Severity of cognitive impairment experienced from multiple sclerosis | Every 24 hours through study completion, an average of 6 months | 
| Change in perceived depression or anxiety severity (self-report) as recorded by symptom diary | Severity of any mood disorders experienced from multiple sclerosis | Every 24 hours through study completion, an average of 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in perceived walking instability (self-report) as recorded by symptom diary |  | Every 24 hours through study completion, an average of 6 months | 
| Change in perceived vision difficulties (self-report) as recorded by symptom diary |  | Every 24 hours through study completion, an average of 6 months | 
| Change in perceived Bowel/Bladder dysfunction (self-report) as recorded by symptom diary | Severity of bowel/bladder dysfunction experienced from multiple sclerosis | Every 24 hours through study completion, an average of 6 months | 
| Change in perceived sensory disturbance (self-report) as recorded by symptom diary |  | Every 24 hours through study completion, an average of 6 months | 
| Change in perceived vertigo severity (self-report) as recorded by symptom diary |  | Every 24 hours through study completion, an average of 6 months | 
| Change in perceived dysarthria severity (self-report) as recorded by symptom diary |  | Every 24 hours through study completion, an average of 6 months | 
| Change in pain (self-report) as recorded by symptom diary |  | Every 24 hours through study completion, an average of 6 months | 
| Change in sleep quality as recorded by app-linked wearable device |  | Every 24 hours through study completion, an average of 6 months | 
| Change in medication adherence (self-report) as recorded by medication diary |  | Every 24 hours through study completion, an average of 6 months | 
| Change in self-efficacy (self-report) as determined by the Multiple Sclerosis self-efficacy scale (survey instrument) |  | every three months, through study completion (an average of 6 months) | 
| Change in Multiple Sclerosis Quality of Life Inventory | The Multiple Sclerosis Quality of Life Inventory surveys are prompted based on the app user's responses on the daily surveys. | prompted based on the app user's responses on the daily surveys, up to 6 months |