Epidemiology of Inflammatory Bowel Disease in the Songpa-Kangdong District, Seoul, Korea.

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the incidence, prevalence, clinical characteristics and prognosis of Crohn's disease and ulcerative colitis over time in a district of Seoul, Korea.

Detailed Description
-----------------
Inflammatory bowel disease (IBD), which is comprised of Crohn's disease (CD) and ulcerative colitis (UC) is a chronic inflammatory disease of gut with uncertain etiopathogenesis. According to our previous study (Yang, et al. Inflamm Bowel Dis 2008; 14: 542-549), the incidence and prevalence of IBD in Korea are still low compared with those in Western countries, but are rapidly increasing. However, the long-term trends of epidemiology of CD and UC together with their characteristics and prognosis in Korea are uncertain yet. The investigators therefore aim to elucidate the incidence and prevalence of CD and UC over a 30-year period, from 1986 to 2017, in the Songpa-Kangdong district of Seoul, Korea. In addition, the investigators also aim to reveal the clinical features at the time of diagnosis of IBD, long-term evolution of disease and prognosis.

Official Title
-----------------
Epidemiology of Inflammatory Bowel Disease in the Songpa-Kangdong District, Seoul, Korea.

Conditions
-----------------
Crohn's Disease, Ulcerative Colitis, Epidemiology, Korea

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Definite cases of CD and UC Patients are diagnosed with CD if they meet at least 2 of the following criteria: clinical history of abdominal pain, weight loss, malaise, diarrhea, and/or rectal bleeding endoscopic findings of mucosal cobblestoning, linear ulceration, skip areas, or perianal disease radiologic findings of stricture, fistula, mucosal cobblestoning, or ulceration macroscopic appearance of bowel wall induration, mesenteric lymphadenopathy, and creeping fat at laparotomy pathologic findings of transmural inflammation and/or epithelioid granulomas Only patients who meet these criteria for at least 2 months are included. Patients are diagnosed with UC only if all 3 of the following criteria are present a typical history of diarrhea or blood and pus or both in the stool for longer than 4 weeks a typical sigmoidoscopic or colonoscopic picture with diffusely granular, friable, or ulcerated mucosa without rectal sparing or skip lesions or radiological signs of characteristic continuous granular or ulcerated mucosa characteristic histopathological signs of inflammation on biopsy Exclusion Criteria: IBD unclassified Ethnic groups other than Korean
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| The Songpa-Kangdong cohort of IBD<br>Incident cases of IBD in the Songpa-Kangdong district, a well-defined administrative area in Seoul, the capital of Korea, beginning in 1986, when the first patient with IBD was diagnosed, until 2017. For the prevalent cases, the inhabitants with IBD at Dec 31, 2007 in the Songpa-Kangdong district are included. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence rate and prevalence rate of IBD | Annual incidence rate of Crohn's disease and ulcerative colitis Prevalence rate of Crohn's disease and ulcerative colitis as of Dec 31, 2017. | 1986-2017 (up to 31 years) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical features of patients with IBD | Clinical characteristics of patients newly diagnosed with Crohn's disease or ulcerative colitis: gender, presenting symptoms, duration between symptoms to diagnosis, and phenotypes, etc. Clinical course of patients newly diagnosed with Crohn's disease or ulcerative colitis: development of complications (strictures, perforations), intestinal resection rate, hospitalization rate, mortality, and pregnancies and their outcomes Treatment modalities of IBD and their trends: use of medication (5-ASA, corticosteroids, immunomodulators, and biologic agents, etc.) | 1986-2017 (up to 31 years) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Crohn's disease, ulcerative colitis, epidemiology, Korea