Antibiotics in Patients With Acute Respiratory Tract Infection With Procalcitonin as Parameter

Study Overview
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Brief Summary
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Antibiotics in patients with acute respiratory tract infections in primary care in consideration of procalcitonin as additive parameter. The purpose of this study is to compare the ordinary manner of antibiotic- prescription with the prescription in consideration of procalcitonin-value in patients with acute respiratory tract infections.

Official Title
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Antibiotics in Patients With Acute Respiratory Tract Infections in Primary Care in Consideration of Procalcitonin as Additive Parameter

Conditions
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Respiratory Tract Infection

Intervention / Treatment
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* Other: laboratory value procalcitonin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 years or older Informed consent Respiratory tract infection based on the clinical judgement of the primary care physician Exclusion Criteria: Antibiotic pretreatment in previous 14 days Portal hypertension Major surgeries or multiple trauma which require hospitalization, in previous 4 weeks Autoimmune disease and systemic diseases (lupus erythematodes, wegener´s disease) Peritoneal dialysis Acute treated or recently operated medullary c-cell-carcinoma, SCLC, carcinoid Other inflammatory diseases (e.g. urinary tract infection, pyelonephritis, pancreatitis

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: laboratory value procalcitonin|A. attending physician includes patient with acute respiratory infection in study, indicates antibiotic prescription and collects procalcitonin-value. Waits for decision from laboratory either change of decision or retention of decision. In case of change decision: antibiotic is not recommended, patient shall not take antibiotic. In case of retention of decision: patient may take the antibiotic. B. attending physician includes patient with acute respiratory infection in study, indicates NO antibiotic and collects procalcitonin-value. Waits for decision from laboratory either change of decision or retention of decision. In case of change decision: antibiotic is recommended, patient has to be informed about. In case of retention of decision: no change.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| days with significant impairment due to acute respiratory tract infection |  | 14 to 28 days after infection | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of antibiotic prescriptions |  | 28 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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primary care, procalcitonin, antibiotic prescription