The Effects of Intravenous Fluids on Perfusion Index and Pleth Variability Index

Study Overview
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Brief Summary
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This study is aimed to assess the effects of intravenously administered three fluid types on perfusion index and pulse variability index in patients during preoperative period. Patients will be randomly divided into three groups. Baseline, 5th, 10th, 15th, 20th, 25th and 30th min non-invasive blood pressure, oxygen saturation, heart rate, room temperature, perfusion index and pulse variability index will be measured and recorded.

Detailed Description
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Intravenous volume replacement alter the dynamics of microcirculation. Perfusion index and pulse variability index are the recent parameters to evaluate the tissue microcirculatory condition. This study is aimed to assess the effects of intravenously administered three fluid types on perfusion index and pulse variability index in patients during preoperative period. Patients will be taken to recovery room in the operating theatre and wait for 15 minutes to balance the skin temperature of the patients to the environment. Patients will be randomly divided into three groups using closed envelope technique as Group L (received 500 ml of Ringer's lactate), Group S (500 ml of saline) and Group H (received 500 ml of 6% hydroxyethylstarch). Baseline, 5th, 10th, 15th, 20th, 25th and 30th min non-invasive blood pressure, oxygen saturation, heart rate, room temperature, perfusion index and pulse variability index will be measured and recorded.

Official Title
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The Evaluation of the Effects of Intravenous Fluids on Perfusion Index and Pleth Variability Index

Conditions
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Perfusion

Intervention / Treatment
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* Drug: sodium chloride
* Drug: Hydroxyethylstarch
* Drug: Ringer-Lactate Infusion Solution Bag


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: having a fasting period of 8 hours quit smoking for 8 hours before the procedure Exclusion Criteria: not to participate in the study presence of peripheral vascular disease a history of upper extremity surgery presence of any kind of psychiatric disease

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: sodium chloride<br>0.9% isotonic sodium chloride, 500 ml, one package in 30 minutes | Drug: sodium chloride<br>* 500 ml of 0.9% isotonic sodium chloride<br>|
| Active Comparator: Hydroxyethylstarch<br>6% hydroxyethylstarch, 500 ml, one package in 30 minutes | Drug: Hydroxyethylstarch<br>* 500 ml of 6% Hydroxyethylstarch<br>|
| Active Comparator: Ringer-Lactate Infusion Solution Bag<br>Ringer's lactate, 500 ml, one package in 30 minutes | Drug: Ringer-Lactate Infusion Solution Bag<br>* 500 ml of Ringer-Lactate Infusion Solution Bag<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Perfusion index | The perfusion of the tissues | six months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart rate | Heart rate | six months | 
| Blood pressure | Non-invasive lood pressure | six months | 
| Oxygen saturation | Blood oxygen saturation using pulse oximeter | six months | 
| Pulse variability index | The intravenous fluid requirement of the tissues | six months |