Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial.

Study Overview
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Brief Summary
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Aim: To evaluate effect of non- surgical periodontal therapy on liver function in systemically healthy chronic periodontitis (CP) subjects. Materials and methods: The study is non surgical interventional trial, includes 50 CP subjects in the age group of 35- 60 years selected from the OPD (Out Patient Department) of department of periodontology Tatyasaheb Kore Dental College and Research center (TKDC and RC), Kolhapur. CP subjects were equally divided into test group and control group. Liver function test- aspartate aminotransferase (AST), alanine aminotransferase (ALT) were checked at baseline and at 1 month after treatment. Clinical examination includes plaque index, gingival index, sulcus bleeding index, probing depth, clinical attachment loss.

Conditions
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Chronic Periodontitis (CP) Subjects.

Intervention / Treatment
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* Procedure: Scaling and root planing


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects with CP (moderate and severe) as per Centers for disease control and prevention (CDC) criteria 2007. Patients without any known systemic diseases - Exclusion Criteria: Patients who have taken anti-inflammatory/antibiotic/antioxidant within 3 months of beginning of study. Subjects who have undergone periodontal treatment within six months of inception of study. Smokers, tobacco habits in any form and alcoholics. Pregnant and lactating women. -

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Scaling and Root Planing( SRP)<br>This was an interventional study in which scaling and root planing was done in systemically healthy patients with chronic periodontitis | Procedure: Scaling and root planing<br>* scaling and root planing as an intervention was done in patients of the test group<br>|
| No Intervention: Control Group<br>Scaling and root planing was not done , that is no intervention is carried out in the patients of this group. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Alanine aminotransferase |  | 1month | 
| Aspartate aminotransferase |  | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| plaque index |  | 1month | 
| gingival index |  | 1 month | 
| sulcus bleeding index |  | 1month | 
| probing depth |  | 1month | 
| Clinical attachment loss |  | 1 month |