linjc16/ctgov huggingface dataset:
Mechanisms of Inflammatory Liver Injury

Study Overview
=================
Brief Summary
-----------------
White blood cells can cause liver damage if they inappropriately accumulate in the liver in large numbers. Such an event can occur if an individual's blood is exposed to endotoxin, a substance released from the cell walls of many species of bacteria. The purpose of this study is to isolate neutrophils, an important white blood cell, from the blood of normal volunteers, and put them in tissue culture with isolated liver cells. The experiments will determine how endotoxin can increase the ability of neutrophils to damage liver cells. All studies supported by this grant will be done with isolated cells in tissue culture. This experimental model will reveal possible mechanisms that can in the future be evaluated in human diseases such as bacterial sepsis.

Detailed Description
-----------------
Neutrophils will be isolated from normal human volunteers and placed in cell culture with isolated hepatocytes or C3A cells (hepatoblastoma cell line that exhibit many characteristics of normal hepatocytes). These experiments will evaluate the mechanisms by which neutrophil adhere to the surface of hepatocytes, and the mechanisms by which the attached neutrophils can damage or kill the hepatocytes. Mechanisms of adhesion will involve understanding of the chemokines released by the hepatocytes that stimulate neutrophil adhesiveness, the cytokines that activate hepatocytes to express chemokines and adhesion molecules, the adhesion receptors on the neutrophil surface that are able to recognize the adhesion molecules on the hepatocyte surface, and the ability of adhesion to enhance and focus cytotoxic chemicals coming from the stimulated neutrophils. In addition, the role endotoxin can play in these sequence of events is being studies, and the specific cytotoxic mechanisms released by the neutrophils are under study. As noted in the brief summary, this grant only supports use of human cells in vitro (i.e., all experiments will be done in tissue culture). The purpose of working with this experimental model is to define what mechanisms should in future experiments be evaluated in patients with endotoxin induced disease.

Conditions
-----------------
Liver Diseases

Participation Criteria
=================
Eligibility Criteria
-----------------
Only blood from normal subjects will be used in the in vitro experiments.

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Liver, Inflammation, Endotoxin, Neutrophils, Hepatocytes
Acute Effects of HIIT and SSMIT on Intraocular Pressure Among Sedentary Individuals

Study Overview
=================
Brief Summary
-----------------
Purpose to study the acute effects of both forms of aerobic exercise (HIIT and SSMIT) on intraocular pressure among healthy sedentary individuals

Detailed Description
-----------------
40 participants were recruited and divided into 2 groups. Each group performed 2 exercise protocols with a 4 day washout period between them. The intraocular pressure was measured before the exercise and after the exercise in 5 minute periods up until 30 minutes post exercise. The intraocular pressure was measured using a handheld rebound tonometer.

Official Title
-----------------
Acute Effects of High Intensity Interval Training (HIIT) and Steady State Moderate Intensity Training (SSMIT) on Intraocular Pressure Among Sedentary Individuals

Conditions
-----------------
Intraocular Pressure

Intervention / Treatment
-----------------
* Other: aerobic exercise


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: all University hospital staff Exclusion Criteria: previous ocular trauma surgery in the eligible eye known case of glaucoma or glaucoma suspect (IOP > 21mmHg) history of glaucoma laser procedure/surgery within 6 months in eligible eye unable to undergo IOP measurements undiagnosed visual condition any uncontrolled medical condition such as end stage renal failure, uncontrolled diabetes and uncontrolled hypertension

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group A<br>undergo HIIT first then SSMIT protocol | Other: aerobic exercise<br>* aerobic exercise HIIT : High intensity interval training SSMIT : Steady state moderate intensity training<br>|
| Active Comparator: Group B<br>undergo SSMIT first then HIIT protocol | Other: aerobic exercise<br>* aerobic exercise HIIT : High intensity interval training SSMIT : Steady state moderate intensity training<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in intraocular pressure | changes in intraocular pressure before and after exervcise | 30 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| compare which form of exercise (HIIT & SSMIT) is superior in reducing intraocular pressure | difference in intraocular pressure reduction observed between each exercise protocol | 30 days |
Atrial Fibrillation Registry in Jordan

Study Overview
=================
Brief Summary
-----------------
Prospective registry of all new comers with Atrial fibrillation

Detailed Description
-----------------
12 tertiary care centers will enroll all AF comers. Details of baseline clinical, EKG, echo, and lab data will be documented for all patients. Management is according to the physicians discretion. Patients will be followed up for 1 year for clinical endpoints including cardiovascular death, stroke, heart failure, systemic embolization and bleeding.. Anticoagulants and other cardiovascular medications will also be documented.

Official Title
-----------------
Atrial Fibrillation Registry in Jordan

Conditions
-----------------
Atrial Fibrillation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Admission with atrial fibrillation developing atrial fibrillation during hospitalization for mon AF reason. age 18 or more years. patients welling to participate in the registry. Exclusion Criteria: age less than 18 years. patients not welling to participate.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| AF cohort<br>AF consecutive patients | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of stroke and systemic embolization and cardiovascular death | all ischemic and hemorrhagic strokes and embolization to any arterial bed during follow up period | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of readmission for atrial fibrillation | readmission for atrial fibrillation related problem other than primary such as palpitations, hypotension, syncope, or near syncope. | 1 year | 
| Number of readmission for other cardiovascular events | Atrial Fibrillation in Jordan: risk factors, presentations, in hospital management, long term management, clinical events in hospital and at one year | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Atrial fibrillation, Registry, Middle East, Jordan, risk factors, in hospital management, long term management
Postoperative Multiparameter Outcomes During the Six Months After Rotator Cuff Repair

Study Overview
=================
Brief Summary
-----------------
Rotator cuff tears are common amongst 50-60 year olds with no connection to their physical activity. When symptomatic, the injury affects all aspects of general health, quality of life and function. Surgical intervention is recommended only if conservative treatment fails. The purpose of the surgical intervention is to reduce pain, and improve function while improving range of motion and muscle strength around the shoulder. The purpose of the current study is to measure physical, functional, expectation, satisfaction and quality of life outcomes after rotator cuff repair surgery. Another purpose is to learn the reproducibility components of the above outcomes.

Conditions
-----------------
Shoulder Pain, Quality of Life, Satisfaction

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with chronic tears in supraspinatus and infraspinatus tendon Symptoms of up to 12 months No relief from conservative treatment Complete or almost complete tears of up to 3cm Hebrew speakers Exclusion Criteria: Previous trauma Shoulder Infection Recurrent dislocation Avascular necrosis Frozen shoulder Additional tears Otherwise healthy

Ages Eligible for Study
-----------------
Minimum Age: 45 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Shoulder Function | Outcome measurements will be collected through the use of the Quick Disability of Arm Shoulder and Hand Score (QuickDASH) questionnaire. | Six Months | 
| Quality of Life | Outcome measurements will be collected through the use of the Twelve Item Health Status Survey (SF12) | Six Months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Self-Rated Improvement, Expectations and Satisfaction | Outcome measurements will be collected through the use of the Patient Global Rating of Change Questionnaire | Six Months | 
| Range of Motion of the Shoulder | Outcome will be measured through the use of a digital inclinometer | Six Months | 
| Isometric strength around the shoulder | Outcome will be measured by a hand-held dynamometer (HHD) | Six months |
Reduction of Abdominal Obesity and Insulin Resistance in Women

Study Overview
=================
Brief Summary
-----------------
The purpose of the study was to assess the effects of equivalent diet- or exercise-induced weight loss and related insulin resistance in abdominally obese women.

Official Title
-----------------
Reduction of Abdominal Obesity and Insulin Resistance in Women

Conditions
-----------------
Obesity

Intervention / Treatment
-----------------
* Behavioral: Diet Weight Loss
* Behavioral: Exercise Weight Loss
* Behavioral: Exercise Without Weight Loss


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Premenopausal women Exclusion Criteria: Smokers and diabetics

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: C<br>Control | |
| Active Comparator: DWL<br>Diet Weight Loss | Behavioral: Diet Weight Loss<br> <br> |
| Active Comparator: EWL<br>Exercise Weight Loss | Behavioral: Exercise Weight Loss<br> <br> |
| Active Comparator: EWS<br>Exercise Without Weight Loss | Behavioral: Exercise Without Weight Loss<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Abdominal Obesity |  | 4 months | 
| Insulin Resistance |  | 4 Months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Obesity, exercise, diet, insulin resistance
Spectral Computed Tomography With Photon Counting Detector of Brain and Vessels.

Study Overview
=================
Brief Summary
-----------------
Primary purpose of the study is to show wether computed tomography with photon counting detector has a diagnostic image quality as good as, or better than classic computed tomography in investigations concerning stroke work-up.

Detailed Description
-----------------
Images of the skull/brain at the level of the inner ear/temporal bone and the level of nucleus lentiformis will be compared with the same patients routine brain done in TIA (transient ischemic attack)/stroke workup. Images of the carotid plaque will be compared with the same patients routine CT-angiogram done in TIA/stroke workup.

Official Title
-----------------
Spectral Computed Tomography With Photon Counting Detector of Brain and Vessels.

Conditions
-----------------
Tomography, Stroke

Intervention / Treatment
-----------------
* Other: Not applicable - no intervention.


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Brain exam with CT and/or CT neck/brain vessels prior to this study. Regarding neck-vessel imaging - carotid stenosis of 30% or more. Normal kidney function. Exclusion Criteria: no contraindications to iodine contrast for neck-vessel imaging with contrast.

Ages Eligible for Study
-----------------
Minimum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Not applicable - no intervention.|No intervention is performed, just a CT with a new detector and comparison with the same patients older image.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Equal or better images vs classic computed tomography. | Are images taken with photon counting detector of brain and vessels worse, equal or better in comparison with ordinary computed tomography. Comparison of images with kernals (or algorithms) for bone and soft tissue at the level of the carotid plaque, inner ear/hindbrain and nucl lentiformis. Comparison of the ability of the spectral function - the ability to separate iodine, soft tissue and calcifications- if applicable. The comparison will be done as a grading (better, equal or worse) regarding the different kernals compared to routine CT exams from the same patient. Significance of difference between proportions with thh use of Fisher's exact test or Pearson's χ2 as appropriate. Evaluation with Cohen´s kappa with 95% CI to assess the level of inter-reader agreement | During 2020 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnostic information in comparison with MRI | If MRI are performed of the patients brain and/or vessels - a comparison how the diagnostic information is/are relative images from MRI | During 2020 |
A 6-Month Extension Study of OTO-104 in Meniere's Disease

Study Overview
=================
Brief Summary
-----------------
This is an open-label extension study of a single intratympanic injection of OTO-104 given every 3 months for a total of 2 injections. Subjects must have completed either Otonomy study 104-201403 (1-Year, Phase 2, Safety Study of OTO-104) or 104-201508 (Phase 3 Study of OTO-104) in order to be eligible for this open-label extension study.

Official Title
-----------------
A 6-Month, Multicenter, Phase 3, Open-Label Extension Safety Study of OTO-104 Given At 3-Month Intervals by Intratympanic Injection in Subjects With Unilateral Meniere's Disease

Conditions
-----------------
Meniere's Disease

Intervention / Treatment
-----------------
* Drug: OTO-104


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria includes, but is not limited to: Subject has completed the Phase 2 OTO-104 1-Year Safety Study (104-201403) or Phase 3 (104-201508) clinical study. Subject has a diagnosis of definite unilateral Meniere's disease by 1995 AAO-HNS criteria Exclusion Criteria includes, but is not limited to: Subject is pregnant or lactating. Subject has a history of immunodeficiency disease. Subject has experienced an adverse reaction to intratympanic injection of steroids.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: OTO-104<br>12 mg dexamethasone | Drug: OTO-104<br>* Single intratympanic injection of 12 mg OTO-104<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Otoscopic Examination - Tympanic Membrane Perforation at Week 24 (Month 6) | Otoscopic exams were conducted at each visit. It was considered important to understand if the tympanic membrane perforation that resulted from the IT injection persisted at the end of study visit (24 Weeks [Month 6]). | 6 Months |
Angiogram Based Fractional Flow Reserve FFRangio - A Validation Study

Study Overview
=================
Brief Summary
-----------------
In the present study we aim at validating the computation of FFRangio values from the angiogram by comparing them to measured wire-based FFR values, in a larger scale and in a completely blinded manner. Investigation of a wide range of users in various conditions may strengthen the reliability of the FFRAngio measurements.

Official Title
-----------------
Angiogram Based Fractional Flow Reserve FFRangio - A Validation Study

Conditions
-----------------
CAD - Coronary Artery Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male and female above 18 years old age which undergo FFR as part of their standard care TIMI Grade Flow is equal to 3 LVEF larger than 45%. Subjects with multi-vessel coronary artery disease, with NSTEMI are allowed. Exclusion Criteria: Contraindicated for FFR examination or adenosine administration STEMI CTO TIMI Grade Flow below 3 Arteries supplying akinetic or severe hypokinetic territories Prior CABG on the study vessel Left Main stenosis, In-stent restenosis and Collaterals Diffused atherosclerosis diseases and tandem lesions Aorto-ostial lesion

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lesion-specific image-based FFRAngio calculation, compared to the invasive FFR as the reference gold standard, with a blinded analysis yielding Bland- Altman of +/- 15% with 95% CI | Immediately following the invasive FFR procedure. | 1 hour |
Povidone Iodine Irrıgation at Hip-Knee Arthroplasty

Study Overview
=================
Brief Summary
-----------------
Povidone iodine (PI) solution is an antimicrobial solution that can be used at hip and knee arthroplasty cases. It contains iodine that may be absorbed by the body. This study aims to investigate any absorption caused by PI solution.

Official Title
-----------------
Evaluation of the Systemic Effect of Intraoperative Diluted Povidone Iodine Irrigation Using Urine Iodine and Thyroid Function Tests in Patients Undergoing Knee-Hip Arthroplasty

Conditions
-----------------
Osteoarthritis, Hyperthyroidism, Iodine Toxicity

Intervention / Treatment
-----------------
* Procedure: PI solution
* Procedure: Saline Solution


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients with hip/knee osteoarthritis who undergo primary arthroplasty Exclusion Criteria: Patients with abnormal thyroid function tests in the preoperative period, a history of the previous thyroid-related disease.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Povidone Iodine Solution<br>The group whom PI solution will be used at surgery | Procedure: PI solution<br>* 3,000 cc of <2% concentrated povidone iodine solution will be used as irrigation solution at primary hip/knee arthroplasty. The PI solution was left in the joint for 3 minutes.<br>|
| Placebo Comparator: Saline Solution<br>The group whom only saline solution will be used at surgery | Procedure: Saline Solution<br>* 3,000 cc of 0.9% saline solution will be used as irrigation solution at primary hip/knee arthroplasty. The saline solution was left in the joint for 3<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Urine iodine level | Urine iodine concentration | postoperative first day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Thyroid hormone | Blood thyroid hormone levels including: TSH, T3 and T4 | postoperative 14 days |