Clinical Outcomes in Patients Referred to Pulmonary Rehabilitation

Study Overview
=================
Brief Summary
-----------------
Chronic obstructive pulmonary disease is a chronic inflammatory lung disease that causes obstructed airflow from the lung, characterized by chronic cough, dyspnea, and sputum production, which often misunderstood as aging or catching a cold. These symptoms may be progressive over time. To provide better disease management and early detecting, pulmonary rehabilitation is now considered a fundamental component of the integrated disease management of this population. However, few studies have evaluated the beneficial outcomes in patients referred to pulmonary rehabilitation. Therefore, the purpose of this study is to investigate the clinical outcomes in patients referred to pulmonary rehabilitation in National Taiwan University Hospital.

Official Title
-----------------
Longitudinal Study of Clinical Outcomes in Patients Referred to Pulmonary Rehabilitation

Conditions
-----------------
Chronic Obstructive Pulmonary Disease

Intervention / Treatment
-----------------
* Other: Pulmonary rehabilitation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: age > 20 years old patients with chronic respiratory disease diagnosed by physician that referred to pulmonary rehabilitation in National Taiwan University Hospital including, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, bronchiectasis can cooperate with pulmonary rehabilitation clinic Exclusion criteria: angina, acute myocardial infarction in the previous one month pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Chronic obstructive pulmonary disease<br>Subjects with the diagnosis of chronic respiratory disease, such as chronic obstructive pulmonary disease, bronchiectasis, idiopathic pulmonary fibrosis that referred for evaluation as routine care at Physical Therapy Center (National Taiwan University) | Other: Pulmonary rehabilitation<br>* Pulmonary rehabilitation as routine care includes, airway clearance techniques, breathing exercise, and physical training instruction<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Functional exercise capacity using the six-minute walk test | The six-minute walk test is commonly performed to evaluate functional exercise capacity. The six-minute walk test was performed according to the guidelines, and the distance walked in the test presented as functional exercise capacity. | The six-minute walk test needs six minute to complete the test | 
| Muscle strength: hand grip | Hand grip strength is performed by using hand dynamometer | Hand grip of both hands need about three minutes to complete | 
| Lung hygiene | Lung hygiene is evaluated by the frequency of acute exacerbation | Lung hygiene is evaluated as the frequency of acute exacerbation in the the past one year | 
| Home-based physical activity | All subjects were encouraged to increase their daily physical activity and recorded the amount of physical activity on patient-self-record training log. | Record the home-based physical activities everyday that the subjects have in the past one week that lasting for one year. | 
| Muscle strength: leg press | Maximum leg press is performed by using seated leg press machine | Maximum leg press measurement needs about four minutes to complete | 
| Heart rate | Heart rate is measured at rest, during hospital-based physical training. | Hospital-based physical training takes 30 minutes, once a week, and it also takes 30 min to measure continuously | 
| Blood pressure | systolic and diastolic pressure are measured at rest, during hospital-based physical training. | Hospital-based physical training takes 30 minutes, once a week, and it also takes 30 min to measure continuously | 
| Perceived dyspnea | Rating of perceived dyspnea is measured by using Borg scale at rest, during hospital-based physical training, and home-based physical activity. The most widely used tool is the Borg scale, with rating ranges from 0 (nothing at all) to 10 (extremely dyspnea). | It takes less than one minute to evaluate perceived dyspnea. | 
| Oxygen saturation | Oxygen saturation is continuously monitored by pulse oximetry throughout Hospital-based physical training. | Hospital-based physical training takes 30 minutes, once a week, and it also takes 30 min to measure continuously |