Vitamin D and Stroke

Study Overview
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Brief Summary
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Stroke remains one of the most devastating neurological diseases, often causing death, or gross physical impairment. It is the second most common cause of death worldwide and a major cause of acquired disability in adults.Vitamin D deficiency has been reported to contribute to the risk of cardiovascular disease especially stroke.

Detailed Description
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This case -control observational prospective study will conducted on fifty patients with first -ever acute onset stroke within seven days (25 patients with hemorrhagic stroke and 25 patients with ischemic stroke )

Official Title
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Vitamin D and Stroke: A Comparative Study to Risk Factors and Stroke Type

Conditions
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Stroke

Intervention / Treatment
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* Dietary Supplement: Vit D


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Onset is within one week Confirmed stroke by brain CAT and / or MRI scan either haemorrhage or infarction Exclusion Criteria: Cognitive and mental changes Recurrent stroke Hepatic and renal impairment Endocrinal diseases Steroid therapy Vitamin D or Ca supplementation Previous fractures Bone diseases brain neoplasm, Autoimmune diseases History of acute and chronic inflammatory diseases Malignancy, Trauma Surgery Acute vascular diseases that occurred within four weeks prior the onset of stroke History myocardial infarction ˂3 months.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1 (hemorrhagic stroke)<br>All participants will be subjected to thorough history taking, full clinical and neurological examination. Stroke subtype will be classified according to the criteria of Trial of Org 10172 in acute Stroke Treatment (TOAST) classification. | Dietary Supplement: Vit D<br>* It is to examine the relationship between serum 25 (OH) D levels and Stroke either ischemic or hemorrhagic types<br>|
| Group 2 (Ischemic stroke)<br>All participants will be subjected to thorough history taking, full clinical and neurological examination. Stroke subtype will be classified according to the criteria of Trial of Org 10172 in acute Stroke Treatment (TOAST) classification. | Dietary Supplement: Vit D<br>* It is to examine the relationship between serum 25 (OH) D levels and Stroke either ischemic or hemorrhagic types<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| serum 25 (OH) D levels | serum 25 (OH) D levels | Within the first 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Stroke severity | Stroke severity will be assessed by Scandinavian Stroke scale Stroke (SSS) | Within the first 24 hours | 
| Stroke etiology |  | Within the first 24 hours | 
| Stroke risk factors |  | Within the first 24 hours | 
| Stroke subtypes |  | Within the first 24 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Vitamin D, Stroke, Parathormone