An Observational Prospective Cohort Study for Long-term Management of Hyperkalemia in Patients With Chronic Kidney Disease or Heart Failure

Study Overview
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Brief Summary
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This prospective observational research will be conducted to assess the burden of hyperkalemia including treatment and disease burden of patients in a long-term continuous care from various aspects including adherence to the medication for hyperkalemia and HR-QoLs.

Official Title
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Hyperkalemia Registry An Observational Prospective Cohort Study for Long-term Management of Hyperkalemia in Patients With Chronic Kidney Disease or Heart Failure

Conditions
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Hyperkalemia

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with hyperkalemia who meet the following criteria: 1) Being treated with potassium binders for hyperkalemia at the time of enrolment, and having started receiving potassium binders within 6 months before enrolment Having been diagnosed as CKD (≥stage 3b) or HF diagnosed by investigators, and as defined below: 1) CKD is diagnosed based on the CKD guidelines issued by the Japanese Society of Nephrologyxxix as being either or both of condition 1 and 2 for ≥3 months 1-i) Clear signs of kidney impairment based on the results of urinalysis, imaging, blood test, or biopsy. Presence of proteinuria, especially more than 0.15 g/gCr (albuminuria more than 30 mg/gCr). 1-ii) GFR <45 mL/min/1.73m2 2) Patients with HFwill be enrolled if patients meet following criteria: 2-i) NYHA class II-IV, within 6 months 2-ii) Patients with a diagnosis or history of heart failure, hospitalization, and laboratory records of any of the following; NT-proBNP≥400 pg/ml or BNP≥100 pg/ml, or pathological findings such as abnormal cardiac function by UCG/CT/MRI/catheterization/nuclear medicine examination Provision of signed, written, and detailed informed consent Exclusion Criteria: Currently on any chronic RRT (including hemodialysis or peritoneal dialysis >30 days, or kidney transplant) within 6 months before enrolment Patients with acute kidney injury (AKI)* within 6 months before enrolment Patients with acute heart failure within 3 months before enrolment Patients who received blood transfusion within 6 months before enrolment Patients with active malignancy or whose life expectancy is less than 6 months GI disturbance, chronic diarrhoea, or GI stoma if, as judged by the investigators, that condition or its treatment has an important impact on S-K values Autoimmune disease if, as judged by the investigators, that condition or its treatment has an important impact on S-K values Patients who are suspected, on the basis of laboratory data, to have pseudohyperkalemia (abnormality in the sample, a history of severe leukocytopenia or thrombocytopenia) Patients with recent traumatic injury Patients who are pregnant, lactating, or planning to become pregnant Current participation in a clinical trials, i.e. an interventional studies Presence of a condition that, in the opinion of the investigator, i) would places the subject at undue risk, or ii) would potentially jeopardizes the quality of the data to be generated, or iii) would prevent the patient from performing protocol-defined tasks for physical or mental reasons, or iv) would prevent the patient from understanding the contents of the self-administered questionnaire and responding to its questions on his/her own, or v) would, for some other reason, make the patient inappropriate for this study.

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hyperkalemia patient with Chronic kidney disease<br> | |
| hyperkalemia patient with heart failure<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient characteristics including socio-demographic variables, severity of disease and comorbidities |  | 6 month | 
| Health-Related Quality of Life |  | 6 month | 
| Serum Potassium |  | 6 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nutritional status |  | 6 month | 
| Status of metabolic acidosis |  | 6 month | 
| Use of healthcare resource |  | 6 month |