Wroclaw Out-Of-Hospital Cardiac Arrest Registry

Study Overview
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Brief Summary
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The purpose of this study is to assess the efficacy of institutionalized care program of patients with out-of-hospital cardiac arrest.

Detailed Description
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Patients with out-of-hospital cardiac arrest included in the program will be treated with extracorporeal membrane oxygenation (ECMO) assisted cardiopulmonary resuscitation (CPR) with additional invasive procedures including coronary/pulmonary angiography and intervention. This type of treatment was not provided in institutionalized fashion in Wroclaw, Poland. Implementation of this program should improve survival in out-of-hospital cardiac arrest patients, which currently is less than 10%.

Official Title
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Wroclaw Out-Of-Hospital Cardiac Arrest Registry

Conditions
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Out-Of-Hospital Cardiac Arrest

Intervention / Treatment
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* Other: ECMO assisted CPR in out-of-hospital cardiac arrest


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age < 60 years witnessed sudden cardiac arrest with immediate CPR supposed cardiac cause of the event ventricular fibrillation (VF) or pulseless ventricular tachycardia (VT) at first medical contact with 3 unsuccessful defibrillations (no ROSC) CPR conducted with Lund University Cardiopulmonary Assist System (LUCAS™) Estimated transfer time from the scene to the Emergency Department < 30 minutes. End tidal carbon dioxide (ETCO2) > 10 mmHg Exclusion Criteria: Total presumed time from 112 call to ECMO implantation longer than 60 minutes Age < 18 years old or > 60 years old; Non-shockable initial rhythm Unavailability of the automated CPR device Unavailability of the catheterisation laboratory Severe concomitant illness with decreased life expectancy Severe body injury Severe active bleeding Drowning Terminal cancer

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Out-of-hospital cardiac arrest<br>Patients with out-of-hospital cardiac arrest which occured in the predefined area of the city of Wroclaw. | Other: ECMO assisted CPR in out-of-hospital cardiac arrest<br>* Patients included in the registry will be transferred during LUCAS assisted CPR by the Wroclaw Emergency Medical Services to the Emergency Department of the Wroclaw University Hospital where blood gasses will be assessed. If two or more of the following: end-tidal carbon dioxide (CO2) > 10 mm Hg, arterial partial pressure of oxygen (PaO2) >50 mm Hg or oxygen saturation >85%, and lactic acid <18 mmol/L will be fulfilled patient will be further transferred to the Cardiac Catheterization Laboratory for V-A ECMO implantation followed by coronary/pulmonary artery angiography and intervention.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mortality | all cause mortality | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| degree of disability | Modified Rankin Scale of 3 or lower | 3 and 6 months after index event | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cardiac arrest, ECMO, ECMO-CPR