Protein Supplements in Association With Prehabilitation Program for Cancer Patients Before Surgery

Study Overview
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Brief Summary
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The aim of study is to analyse the feasibility of the use of nutritionnal complements after exercices before surgery for cancer. Body composition, muscle function and muscle mass will be analyse too.

Detailed Description
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A prospective study will be carried out including adult patients with neoplasia who should benefit in their therapeutic strategy from oncological surgery. About fifty patients will be recruited in the oncology / surgery department at the Saint-Luc University Clinics in Brussels. Patients will be assessed at the initial consultation and after the pre-habilitation period, ie the day before the operation. Dietary monitoring will be carried out in parallel with a physical and respiratory preparation program (prehabilitation) and the intake of protein nutritional supplements in the form of powder to be diluted will be carried out after each exercise session.

Official Title
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Suppléments protéinés en Association d'un Programme de préhabilitation Avant la Prise en Charge Chirurgicale d'un Cancer

Conditions
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Cancer, Surgery, Prehabilitation

Intervention / Treatment
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* Dietary Supplement: Whey protein


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patient with operable cancer patient inform consent min 18 years old french or english speaking Exclusion Criteria: neuromuscular pathology cardiorespiratory or orthopedic pathology that prevents physical activity cognitive or psychiatric disorders

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Nutritional complement<br>A prospective study will be carried out including adult patients with neoplasia who should benefit in their therapeutic strategy from oncological surgery. About fifty patients will be recruited in the oncology / surgery department at the Saint-Luc University Clinics in Brussels. Patients will be assessed at the initial consultation and after the pre-habilitation period, ie the day before the operation. Dietary monitoring will be carried out in parallel with a physical and respiratory preparation program (prehabilitation) and the intake of protein nutritional supplements in the form of powder to be diluted will be carried out after each exercise session. | Dietary Supplement: Whey protein<br>* Patient receive protein supplement in liquid form after each exercice session<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adhesion rate of the use of nutritionnel complements after exercices before surgery for cancer | The feasibility of this outcome will be assess by the adhesion rate : (number of protein shots taken) / (number of protein shots prescribed). The adhesion will be validated if> 75% of the holds are respected. | 3 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body composition (lean and fat mass) | Evaluated by an impedancemetry balance : pourcentage of lean and fat mass | Once at the inclusion and once the day before surgery (3 weeks) | 
| Muscle function | This variable will be studied by the 6-minutes walk test (meters) | Once at the inclusion and once the day before surgery (3 weeks) | 
| Nutritional biological markers | These variables will be studied by: prealbumin (g/L) and albumin (g/L) measures | Once at the inclusion | 
| Antropometric markers - height | Height (meters) | Once at the inclusion and once the day before surgery (3 weeks) | 
| Muscle strength | This variable will be studied by the hand grip test (kilograms) | Once at the inclusion and once the day before surgery (3 weeks) | 
| Antropometric markers - weight | Weight (kilograms) | Once at the inclusion and once the day before surgery (3 weeks) | 
| Antropometric markers - BMI | BMI (kg/m²) :weight and height will be combined to report BMI in kg/m² | Once at the inclusion and once the day before surgery (3 weeks) |