Electroencephalogram and Attention Deficit Hyperactivity Disorder Study

Study Overview
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Brief Summary
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The purpose of this research is to assess and determine brain oscillations or brain signatures of adult participants with Attention Deficit Hyperactivity Disorder (ADHD) relative to adult participants without ADHD using the technique electroencephalogram (EEG). Electroencephalogram is entirely non-invasive way of tracking brain activity.The main goal of this study is to establish biological factors for determining the diagnosis of Attention Deficit Hyperactivity Disorder (ADHD).

Official Title
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EEG and ADHD Study

Conditions
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Attention Deficit Hyperactivity Disorder, Healthy Controls

Intervention / Treatment
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* Device: Electroencephalogram (EEG)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria for all: Right-handedness Inclusion Criteria for Attention Deficit Hyperactivity Disorder (ADHD) group: Currently unmedicated adults with ADHD. To be given a full diagnosis of adult ADHD, the participant must have full Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-R) criteria: (1) described a chronic course of ADHD symptomatology from childhood to adulthood, and (2) endorsed a moderate or sever level of impairment attributed to the ADHD symptoms. Exclusion Criteria for all: Currently taking psychoative medications Any clinically significant neurological problem (e.g., tics, seizures, serious head injury) Alcohol or substance abuse (current or in the past 2 years) Any current Axis I psychiatric diagnosis (other than ADHD) as verified by clinical interview

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Attention Deficit Hyperactivity Disorder<br>This study aims to recruit 100 adult participants: 50 of which are adults diagnosed with Attention Deficit Hyperactivity Disorder and 50 healthy controls. All participants will perform a total of two tasks while connected to electroencephalogram (EEG) sensors; the first task is a resting state task and after that a cognitive challenge task (attention control). Study activity is performed in a single visit which lasts two hours. Participants will also be asked to complete some behavioral questionnaires. | Device: Electroencephalogram (EEG)<br>* The electroencephalogram assesses brain electrical activity through surface recording disks (electrodes) which are placed near the participants' head using a custom designed Lycra cap. The electrodes transmit the signals which are then amplified and stored on a computer. The procedure is entirely non-invasive. Once an accurate signal is assured, the signal derived from the electrode cap is then amplified, transmitted to a computer, and stored for later analysis. Each participant will undergo the electroencephalogram (EEG) procedure only once for the duration of 30-45 minutes.<br>* Other names: BEU Number: 409917;|
| Healthy Control<br>This study aims to recruit 100 adult participants: 50 of which are adults diagnosed with Attention Deficit Hyperactivity Disorder and 50 healthy controls. All participants will perform a total of two tasks while connected to electroencephalogram (EEG) sensors; the first task is a resting state task and after that a cognitive challenge task (attention control). Study activity is performed in a single visit which lasts two hours. Participants will also be asked to complete some behavioral questionnaires. | Device: Electroencephalogram (EEG)<br>* The electroencephalogram assesses brain electrical activity through surface recording disks (electrodes) which are placed near the participants' head using a custom designed Lycra cap. The electrodes transmit the signals which are then amplified and stored on a computer. The procedure is entirely non-invasive. Once an accurate signal is assured, the signal derived from the electrode cap is then amplified, transmitted to a computer, and stored for later analysis. Each participant will undergo the electroencephalogram (EEG) procedure only once for the duration of 30-45 minutes.<br>* Other names: BEU Number: 409917;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Brain Wave Measurements | Measurement of electroencephalogram amplitude and coherence in alpha, gamma, and theta brain wave bands. | Two years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Default Network Signatures | Measurement of the brain's default network consisting of interconnected midline and lateral parietal regions involved in internally directed mentation. | two years |