Pioglitazone on Viral Kinetics, Cytokines and Innate Immunity in Insulin Resistant CHC GT 1 Subjects

Study Overview
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Brief Summary
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The purpose of this study is to determine if rosiglitazone, a medicine used to treat diabetes, improves response to anti-viral treatment.

Detailed Description
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The aim of the study will be to determine if an insulin sensitizing thiazolidinedione (TZD) improves (1) baseline viremia, (2) enhances viral kinetics, (3) improves cytokine profiles and (4) up regulates innate cellular immunity (presumably adaptive immunity is up regulated as well) as measured by the bioactivity of the collected biomarkers.

Official Title
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Assessment of the Efficacy of Pioglitazone on Viral Kinetics, Cytokines, and Innate Immunity in a Group of Insulin Resistant, Treatment Naïve, Chronic Hepatitis C, Genotype 1 Patients

Conditions
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Chronic Hepatitis C

Intervention / Treatment
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* Drug: Pioglitazone (Actos)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: HCV-Ab or HCV-RNA by PCR Positive for at least six months (to rule out acute seroconversion) Serum positive for HCV-RNA by PCR assay Must have insulin resistance, defined as a QUICKI score < 0.35. QUICKI Liver biopsy consistent with CHC within 24 months prior to enrollment Compensated liver disease with the following minimum hematological, biochemical, and serologic criteria at the Screening Visit (WNL = within normal limits): Hemoglobin values of >12 gm/dL for females and >13 gm/dL for males. WBC >3,000/ mm3 Neutrophil count > 1,500/mm3 Platelets >65,000/ mm3 Direct bilirubin, within 20% of ULN Indirect bilirubin, within normal limits (WNL) Albumin >3gm/dL Serum creatinine < 20% above the ULN TSH WNL Alpha fetoprotein value < 100 ng/mL Exclusion Criteria: Prior interferon based therapy Use of insulin Fasting glucose levels > 200 mg/dl Women who are pregnant or breast-feeding No other thiazolidinedione after liver biopsy and/or during the entire study ( Hepatitis C of non-genotype 1 Suspected hypersensitivity to pioglitazone Any cause for liver disease other than chronic hepatitis C, insulin resistance, or NAFLD, including but not limited to: Hemochromatosis Alpha-1 antitrypsin deficiency Co-infection with HBV Wilson's disease Autoimmune hepatitis Significant alcohol use Drug-related liver disease Any condition that would prevent the subject from having a liver biopsy. Hemoglobinopathies that could potentially compromise patient safety Evidence of advanced liver disease such as history or presence of ascites, bleeding varices, spontaneous encephalopathy. Participants with organ transplants other than cornea and hair transplant. Any known preexisting medical condition that could interfere with the subject's participation in and completion of the protocol such as: Preexisting psychiatric condition, especially severe depression, or a history of severe psychiatric disorder, such as major psychoses, suicidal ideation and/or suicidal attempt are excluded Substance abuse, such as alcohol, IV drugs and inhaled drugs Alcohol consumption is to be strongly discouraged Seizure disorders not controlled with medication Significant cardiovascular dysfunction within the past 12 months Chronic pulmonary disease with documented pulmonary hypertension Immunologically mediated disease [e.g., inflammatory bowel disease (Crohn's disease, ulcerative colitis)], rheumatoid arthritis, idiopathic thrombocytopenia purpura, systemic lupus erythematosis, autoimmune hemolytic anemia, scleroderma, severe psoriasis, clinical cryoglobulinemia with vasculitis Any medical condition requiring, or likely to require, chronic systemic administration of steroids during the course of the study Evidence of an active or suspected cancer or a history of malignancy where the risk of reoccurrence is ≥ 20% within two years

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: pioglitazone<br>Treatment with pioglitazone 45 mg a day for 3 months | Drug: Pioglitazone (Actos)<br>* pioglitazone 45 mg a day<br>|
| No Intervention: No intervention<br>Monitoring period without pioglitazone for 3 months | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improvement in baseline viremia and viral kinetics, and/or pro-inflammatory cytokines decrease, and/or markers of innate immunity are upregulated to position a more favorable response to current CHC therapy. |  | 104 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Hepatitis C