Pitch Perception and Memory: Deficits and Training

Study Overview
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Brief Summary
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Pitch perception and memory are central in auditory cognition, in particular for sound source segregation and recognition, speech prosody and music processing. Here the investigator assess pitch perception and memory in hearing-impaired listeners wearing cochlear implant(s) and listeners with congenital amusia, both compared with control listeners. Behavioral, EEG, and MEG measures are collected in audio and audio-visual contexts to characterize pitch processing deficits, and test a pitch training program.

Official Title
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Pitch Perception and Memory: Deficits and Training

Conditions
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Cochlear Implants

Intervention / Treatment
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* Behavioral: Listening tests. Pitch training protocol
* Behavioral: visuo-spatial training protocol
* Behavioral: EEG/MEG/MRI recordings.


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: For adult participants: Aged between 18 and 90 Absence of neurological and psychiatric disorders No major cognitive deficit, ability to understand and apply study instructions Motivation to participate efficiently in the study Written informed consent to participant in the study Affiliated to social security Control participants and participants with congenital amusia for Experiment 5: MRI/MEG compatibility For underage participants: Subject aged 5 years and over Informed consent of parents or guardians for the participation of the child being studied No neurological or psychiatric history Without major cognitive impairment and ability to understand and apply setpoint. Subject affiliated to a social security scheme Motivation to participate effectively in the project Exclusion Criteria: For adult participants: Age below 18 or above 90 Pregnant or breast-feeding woman For underage participants: - Pregnant or nursing minors

Ages Eligible for Study
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Minimum Age: 5 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cochlear implant users<br>In both arms a pitch training protocol and a visuo-spatial training protocol are applied. | Behavioral: Listening tests. Pitch training protocol<br>* The two training protocols consists of perceptual tasks (auditory or visual exercises) performed repetitively using a tablet. Each protocol consists in 30 sessions of  20 minutes performed at home over a period of 15 weeks.<br>Behavioral: visuo-spatial training protocol<br>* The two training protocols consists of perceptual tasks (auditory or visual exercises) performed repetitively using a tablet. Each protocol consists in 30 sessions of  20 minutes performed at home over a period of 15 weeks.<br>Behavioral: EEG/MEG/MRI recordings.<br>* Listening tests. EEG/MEG/MRI recordings<br>|
| Experimental: Participants with Congenital Amusia<br>In both arms a pitch training protocol and a visuo-spatial training protocol are applied. | Behavioral: Listening tests. Pitch training protocol<br>* The two training protocols consists of perceptual tasks (auditory or visual exercises) performed repetitively using a tablet. Each protocol consists in 30 sessions of  20 minutes performed at home over a period of 15 weeks.<br>Behavioral: visuo-spatial training protocol<br>* The two training protocols consists of perceptual tasks (auditory or visual exercises) performed repetitively using a tablet. Each protocol consists in 30 sessions of  20 minutes performed at home over a period of 15 weeks.<br>Behavioral: EEG/MEG/MRI recordings.<br>* Listening tests. EEG/MEG/MRI recordings<br>|
| Experimental: Control Participants<br> | Behavioral: Listening tests. Pitch training protocol<br>* The two training protocols consists of perceptual tasks (auditory or visual exercises) performed repetitively using a tablet. Each protocol consists in 30 sessions of  20 minutes performed at home over a period of 15 weeks.<br>Behavioral: visuo-spatial training protocol<br>* The two training protocols consists of perceptual tasks (auditory or visual exercises) performed repetitively using a tablet. Each protocol consists in 30 sessions of  20 minutes performed at home over a period of 15 weeks.<br>Behavioral: EEG/MEG/MRI recordings.<br>* Listening tests. EEG/MEG/MRI recordings<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| percentages of correct responses in listening tests |  | during procedure | 
| reaction times in listening tests |  | during procedure | 
| Event-Related Fields | MEG measurements | during procedure | 
| Oscillations | MEG measurements | during procedure | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| percentages of correct responses | Performance in listening tests in audio contexts | Day 0 | 
| percentages of correct responses | Performance in listening tests in audio-visual contexts | Day 0 | 
| reaction times | Performance in listening tests in audio contexts | Day 0 | 
| reaction times | Performance in listening tests in audio-visual contexts | Day 0 | 
| Event-Related Fields | EEG measurements | Day 0 | 
| Oscillations | EEG measurements | Day 0 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Hearing, Cochlear Implants, Congenital Amusia, Pitch, Audio-visual interactions