Long-term Outcome of General Anesthesia on Dysgnosia

Study Overview
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Brief Summary
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Cognitive disorders in patients underwent general anesthesia are discussed for decades, but whether there were precise relationship between general anesthesia and dysgnosia is yet to be guaranteed. Although controversial data reported from experimental studies in animals, the investigators still proposed that general anesthetics could impair the normally organized system of the central nervous system, which finally displayed a dysfunction of cognition after general anesthesia in a short- or long-term period. Therefore, different types of general anesthetics such as inhalational anesthetics and intravenous anesthetics, the investigators hypothesized, had a long-term influence on patients' cognitive ability.

Official Title
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Long-term Outcome Followed-up of the Cognitive Disorders After General Anesthesia

Conditions
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Delirium,, Dementia,, Amnestic,, Cognitive Disorders

Intervention / Treatment
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* Drug: Sevoflurane
* Drug: Propofol


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with informed consents Without basal disorders of neurology and psychiatrics Exclusion Criteria: With the history of cognitive disorders With chronic neurological disorders Cannot communicate with investigators Cannot stand general anesthesia

Ages Eligible for Study
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Minimum Age: 10 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Local anesthesia<br>Patients received local anesthesia without any intervention of general anesthetics | |
| Active Comparator: Inhalational anesthesia<br>Patients received sevoflurane anesthesia during general anesthesia | Drug: Sevoflurane<br>* 1-8% sevoflurane for maintaining the whole period of general anesthesia<br>* Other names: Sevorane;|
| Active Comparator: Intravenous anesthesia<br>Patients received intravenous anesthetic (Propofol) during general anesthesia | Drug: Propofol<br>* 1-4 mg/kg/h of propofol during the whole period of general anesthesia<br>* Other names: Diprivan;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognitive ability | Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory | The 10th year since postoperation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognitive ability | Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory | One hour before operation | 
| Cognitive ability | Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory | Immediately after operation (0 day) | 
| Cognitive ability | Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory | One month after operation | 
| Cognitive ability | Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory | Six month after operation | 
| Cognitive ability | Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory | One year after operation | 
| Cognitive ability | Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory | Once a year from the 1st year after operation up to 9th year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cognitive Disorders, General anesthesia, Sevoflurane, Propofol, Memory