Impulse Control in Gilles de la Tourette Syndrome

Study Overview
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Brief Summary
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The study intends to evaluate the role of Mirror Neurons in the determination of gestures, words, and repetitive vocalizations in subjects affected by Tourette's syndrome and to verify if these subjects are faster to assemble sounds, in phonology and morphology, than the non-pathological population.

Official Title
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Do Mirror Neurons Play a Role in Tourette Syndrome Physiopathology? A Pilot Study.

Conditions
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Tourette Syndrome

Intervention / Treatment
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* Other: Routine tests perform


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: TOURETTE GROUP Consecutive patients belonging to the Tourette Center Caucasian Italian mother-tongue Age between 6 and 10 years completed Male and female 4: 1 (16 males and 4 females) Diagnosis of Tourette's syndrome for at least 1 year Presence of a value of YGTSS> 50% NOT GROUP TOURETTE Caucasian Italian mother-tongue Age between 6 and 10 years completed Male and female 4: 1 (16 males and 4 females) Exclusion Criteria: TOURETTE GROUP Diagnosis of DSA Presence of significant psychiatric disorders, with the exception of those belonging to the Tourette Syndrome itself (eg ADHD, OCD). NOT GROUP TOURETTE Diagnosis of DSA Presence of significant psychiatric disorders

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 10 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Tourette group<br>20 subjects with Tourette Syndrome undergoing an evaluation to identify the IQ. Subsequently, 4 tasks are presented. The 1st (with a duration of about 2 and a half minutes) and the 2nd (with a duration of about 2 minutes) concerning the motor field, the 3rd (with duration of about 1 minute) and the 4th (with duration of about 3 minutes) concerning the linguistic field. | Other: Routine tests perform<br>* The subjects of the Tourette group and control group are subjected to routine tests performed at Tourette Center and Extrapyramidal Diseases. Both groups are initially subjected to an evaluation that aims to identify the IQ and therefore 4 tasks are presented. The 1st (with a duration of about 2 and a half minutes) and the 2nd (with a duration of about 2 minutes) related to the motor field, the 3rd (with duration of about 1 minute) and the 4th (with duration about 3 minutes) the language field. These evaluations are in practice at the Center for Tourette patients; the tasks will be administered to both groups.<br>|
| Control group<br>20 subjects without Tourette Syndrome subjected to an evaluation to identify the IQ. Subsequently 4 tasks are presented. The 1st (with a duration of about 2 and a half minutes) and the 2nd (with a duration of about 2 minutes) concerning the motor field, the 3rd (with duration of about 1 minute) and the 4th (with duration of about 3 minutes) concerning the linguistic field. | Other: Routine tests perform<br>* The subjects of the Tourette group and control group are subjected to routine tests performed at Tourette Center and Extrapyramidal Diseases. Both groups are initially subjected to an evaluation that aims to identify the IQ and therefore 4 tasks are presented. The 1st (with a duration of about 2 and a half minutes) and the 2nd (with a duration of about 2 minutes) related to the motor field, the 3rd (with duration of about 1 minute) and the 4th (with duration about 3 minutes) the language field. These evaluations are in practice at the Center for Tourette patients; the tasks will be administered to both groups.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tourette syndrome and the imitation of gestures | The aim is to investigate the correlation between Mirror Neurons and Tourette Syndrome defining the greater propensity of the Tourettian subjects to imitate gestures, through the administration of the first Task | Through study completion, an average of 1 year |