linjc16/ctgov huggingface dataset:
Focused Ultrasound in Septic Shock Patients

Study Overview
=================
Brief Summary
-----------------
The investigators hypothesize that lung ultrasound and echocardiography will benefit the septic shock patients by making the treatment more precisely and rapidly. Septic shock patients from multicenter will be enrolled in the study. They will be randomly divided into two groups. The routine treatment group will receive routine treatment according to the SSC guideline. The study group will receive additional ultrasound examination, which will decide the improvement of therapy. Therapy change based on ultrasound results and the prognosis will be recorded.

Conditions
-----------------
Septic Shock

Intervention / Treatment
-----------------
* Other: ultrasound examination
* Other: Ultrasound group


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age>18yr survive more than 24hrs fulfilled septic shock Exclusion Criteria: age < 18yr pregnant DNR

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Rutine treatment group, Ultrasound group<br> | Other: ultrasound examination<br> <br> Other: Ultrasound group<br>* Ultrasound group will receive ultrasound examination at least once a day, the results will be noted to the attending who is in charge of the treatment.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mortality |  | 28day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
critical ultrasound
Chromocolonoscopy for the Detection of Flat Adenomas in Routine Colorectal Cancer Screening.

Study Overview
=================
Brief Summary
-----------------
The proposed research aims to determine the prevalence, size, shape and histology of flat colorectal neoplasms in a cohort of asymptomatic, average-risk individuals presenting for screening colonoscopy. Patients will be randomized to either conventional colonoscopy or chromocolonoscopy, where the entire colon will be sprayed with indigocarmine dye and examined in the usual manner. The primary outcome will be the total number of adenomas detected, with special attention to the subgroup of flat and depressed lesions. To promote the generalizability of the results, neoplasms will be described according to standard Western and Japanese classification schemes.

Official Title
-----------------
Chromocolonoscopy for the Detection of Flat Adenomas in Routine Colorectal Cancer Screening.

Conditions
-----------------
Colon Cancer, Polyp, Adenoma

Intervention / Treatment
-----------------
* Procedure: Chromocolonoscopy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients undergoing screening colonoscopy Exclusion Criteria: Age < 50 Prior colon resection Inflammatory bowel disease Prior colonoscopy or sigmoidoscopy More than one first-degree relative with colon cancer

Ages Eligible for Study
-----------------
Minimum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Chromocolonoscopy | Procedure: Chromocolonoscopy<br>* Indigocarmine dye applied to entire colon to highlight mucosal detail and enhance detection of flat lesions.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of adenomas detected by chromocolonoscopy versus standard colonoscopy. |  | Cross-sectional prevalence of adenomas between the 2 study groups | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Colonoscopy, Chromoscopy, Prevention
Lubiprostone for Children With Constipation

Study Overview
=================
Brief Summary
-----------------
This study is for children with constipation. Children who completed 3 months of treatment in the earlier study (NCT02042183): were invited to participate will receive lubiprostone for 9 more months will see if lubiprostone safely relieves their constipation if taken for a whole year

Official Title
-----------------
A Multicentre, Long-term Safety, Efficacy, and Pharmacokinetics Study of Lubiprostone in Paediatric Subjects Aged ≥ 6 Years to < 18 Years With Functional Constipation

Conditions
-----------------
Constipation - Functional

Intervention / Treatment
-----------------
* Drug: Lubiprostone


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Has completed the 3-month placebo-controlled study (NCT02042183) Will continue to abstain from taking concomitant medication (prescribed or over-the-counter) that affects gastrointestinal motility Exclusion Criteria: Has untreated faecal impaction at the time of rolling over into study Has significant change in medical status, newly diagnosed and uncontrolled cardiovascular, liver or lung disease, neurologic or psychiatric disorder, or other systemic disease Has demonstrated non-compliance with study protocol during the 3-month placebo-controlled study (NCT02042183)

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 17 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Lubiprostone<br>Participants receive lubiprostone twice daily Participants must have completed the entire 12-week treatment period during the preceding study. Those who received 12 mcg twice daily (BID) continued to receive 12 mcg, those who received 24 mcg BID continued with that dose.Those of the placebo arm in the previous study weighing less than 50 kg received 12 mcg BID and over 50 kg received 24 mcg BID during this study. | Drug: Lubiprostone<br>* 12 or 24 mcg soft capsules for oral administration<br>* Other names: Amitiza®;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Median Number of Observed Weekly Spontaneous Bowel Movements (SBM) Per Month | Spontaneous bowel movements are defined as bowel movements without the aid of drugs. | within 9 months |
Lithium Clearance in Patients With High Risk of Acute Kidney Injury

Study Overview
=================
Brief Summary
-----------------
Renal lithium clearance is hypothesized to be a useful indicator of renal tubular function. In this study lithium clearance will be monitored in patients with sepsis associated acute kidney injury and in healthy controls.

Detailed Description
-----------------
Lithium is almost completely reabsorbed in the proximal tubule in parallel with sodium and water. What is not reabsorbed here is assumed to be fully excreted in urine, giving a reasonably accurate measurement of sodium reabsorption in the proximal tubule. Endogenous lithium clearance will be measured by inductively coupled plasma mass spectrometry (ICP-MS). The Gomez equations will be applied to calculate efferent arteriolar resistance, afferent arteriolar resistance, glomerular hydrostatic pressure, glomerular filtration pressure, and glomerular oncotic pressure. N-acetyl-β-D glucosaminidase (NAG) and NGAL, markers of tubular injury, will be measured by a spectrophotometric method using a commercially available kit. Routine blood and urine analyses will be performed at the Diagnostic Clinic Laboratory, University Hospital of North Norway, Tromsø.

Official Title
-----------------
Proximal Tubule Function in Septic Patients as Measured by Endogenous Lithium Clearance

Conditions
-----------------
Acute Kidney Injury

Intervention / Treatment
-----------------
* Diagnostic Test: Lithium measures


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria sepsis associated acute kidney injury: Sepsis diagnosed or suspected Age >18 years Inclusion Criteria healthy controls: Previously healthy individuals Age >18 years Exclusion Criteria: Oliguria or renal impairment due to other causes than sepsis. Pregnancy or breast-feeding.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sepsis patients<br>No interventions | Diagnostic Test: Lithium measures<br>* Measurements of lithium levels in blood and urine<br>|
| Healthy controls<br>No interventions | Diagnostic Test: Lithium measures<br>* Measurements of lithium levels in blood and urine<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Renal lithium clearance | Measurement of renal lithium clearance at 8AM, 2 PM, and 8 PM | Repeated measures between 07:00-20:00 |
Trial to Determine Which of Two Surgical Techniques Works Better to Correct Vaginal Bulging

Study Overview
=================
Brief Summary
-----------------
Women with vaginal bulging who are undergoing laparoscopic sacrocolpopexy at Clarian Health are eligible to enroll in this study. Two different methods of correcting rectocele at the time of sacrocolpopexy will be compared for surgical outcome, surgical complications, and patient satisfaction with intercourse and bowel function. One of the surgical methods uses an additional graft material and one surgical method does not. It is hypothesized that the method which uses an additional graft material to strengthen the patient's tissues will have a better outcome.

Official Title
-----------------
Does Pelvicol Graft in the Posterior Compartment Offer Any Benefit to Surgical Outcomes During Laparoscopic Sacral Colpoperineopexy?

Conditions
-----------------
Rectocele

Intervention / Treatment
-----------------
* Procedure: Insertion of pelvicol graft


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: women with stage 2 pelvic organ prolapse undergoing laparoscopic sacrocolpopexy Exclusion Criteria: concomitant colo-rectal procedure allergy to pork any contraindication to laparoscopic sacrocolpopexy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Pelvicol graft<br> | Procedure: Insertion of pelvicol graft<br>* Pelvicol graft<br>|
| No Intervention: No graft material<br>No graft material | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anatomic success of rectocele repair |  | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in patient symptomatology post-operatively |  | 6 months |
Prehabilitation Care for Women With Advanced Ovarian Cancer Receiving Neoadjuvant Chemotherapy

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is evaluate whether a prehabilitation program is feasible and useful for women with advanced ovarian cancer receiving chemotherapy in preparation for debulking surgery.

Official Title
-----------------
A Pilot Project to Evaluate Feasibility and Patient Experience of Prehabilitation Care for Women With Advanced Ovarian Cancer Undergoing Neoadjuvant Chemotherapy

Conditions
-----------------
Ovarian Cancer, Stage III Ovarian Cancer, Stage IV Ovarian Cancer, Primary Peritoneal Carcinoma, Fallopian Tube Carcinoma, Fallopian Tube Cancer

Intervention / Treatment
-----------------
* Other: Prehabilitation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subjects must be diagnosed with Stage III or Stage IV ovarian carcinoma (which includes primary peritoneal carcinoma or fallopian rube carcinoma) All subjects must be enrolled within 90 days of diagnosis No prior treatment for ovarian carcinoma All subjects have agreed to a treatment plan of neoadjuvant chemotherapy and subsequent planned interval debulking surgery with an MSKCC surgeon Participants must be initiating treatment at Gynecologic Medical Oncology clinics at MSKCC Manhattan Proficiency in English in the determination of the investigators of by patient self-report Exclusion Criteria: Patient under age 18 Prior treatment for ovarian cancer Second opinion visit only Immediate surgery plan without neoadjuvant treatment No intended surgical plan Chemotherapy administration exclusively planned at MSKCC regional site Patient unwilling to sign consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Participants with Ovarian Cancer<br>Participants are diagnosed with Stage III or Stage IV ovarian carcinoma (which includes primary peritoneal carcinoma or fallopian tube carcinoma) | Other: Prehabilitation<br>* A program of personalized independent home exercises are outline for participants to complete daily. Prehabilitation coaching will continue weekly until admission for surgical tumor debulking or termination of neoadjuvant treatment for any reason.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Median completion of participants | Study will be considered feasible if the cohort has a median completion of 70% or more | Up to 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Ovarian Cancer, Primary peritoneal carcinoma, Fallopian tube cancer, 19-347, Memorial Sloan Kettering Cancer Center
Bikram Yoga and Asthma

Study Overview
=================
Brief Summary
-----------------
Cold and dry air induce exercise induced asthma. Yoga training may improve lung function tests. Bikram Yoga (heat 39 degree Celsius and humidity 60%)training may improve both lung function tests and bronchial hyperreactivity (to exercise and adenosine 5'monophosphate).

Detailed Description
-----------------
15 young adults with exercise induced asthma and 10 healthy young adults will participate in 2 months taining of Bikram Yoga in Tel Aviv. They will perform sessions of 90 minutes training at least 5 times a week. Lung function tests, bronchial challenges (exercise and AMP) and progressive exercise test will be performed before and after the 2 month training at Hadassah University Hospital in Jerusalem in the asthmatic patients. Healthy adults will perform only lung function tsts and progressive exercise before and after training.

Official Title
-----------------
The Influence of Bikram Yoga (39 Degree Celsius Heat and 60% Humidity) on Basic Lung Function Tests,Bronchial Challenges and Pulmonary-Heart Endurance in Young Asthmatic Adults.

Conditions
-----------------
Asthmatics

Intervention / Treatment
-----------------
* Behavioral: Bikram Yoga


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: controlled asthma age 18-30 years Exclusion Criteria: heart, hypertension, kidney disease, chronic lung disease, oxygen dependence

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Bikram Yoga|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prevent exercise induced asthma and improve lung function tests |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
asthma, yoga, heat, humidity, bikram
Surgical Pleth Index- Relevance in Small Children

Study Overview
=================
Brief Summary
-----------------
Surgical Pleth index is a novel device aimed for measurement of intraoperative nosiseption. It has not been tested on small children. The aim of this study is to measure, whether there is a difference in nosiception measured by SPI in a group receiving local anesthetics prior to operation compared to group receiving plasebo.

Official Title
-----------------
Surgical Pleth Index - Relevance in Small Children. A Randomised Double Blinded Study

Conditions
-----------------
Anesthesia

Intervention / Treatment
-----------------
* Drug: Levobupivacaine
* Drug: Saline


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age 0-2 years Elective surgery planned for inguinal hernia, or testicle retention Written informed consent from parent received ASA I-III Exclusion Criteria: Exstrasystolias, known cardiac problem, medication affecting rhytm, allergy to drugs used

Ages Eligible for Study
-----------------
Maximum Age: 2 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Treatment<br>Patients in group receive Ileoinguinal block before the start of surgery, and an injection of plasebo saline after surgery. Injectate is blinded from caregiver. | Drug: Levobupivacaine<br> <br> Drug: Saline<br> <br> |
| Placebo Comparator: Control group<br>Patients receive a plasebo saline injetion at the site of ileoinguinal block prior to surgery and an injectio with local anesthetics after surgery. The treatment group is blinded for caregiver. | Drug: Levobupivacaine<br> <br> Drug: Saline<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Surgical Pleth Index (SPI) at the time of start of surgery |  | intraoperative | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Measurement, nosiseption
Study for Novel Coronavirus Pneumonia (NCP)

Study Overview
=================
Brief Summary
-----------------
To develop practical and effective clinical diagnosis and treatment schemes for the control of novel coronavirus pneumonia.

Detailed Description
-----------------
By retrospectively analyzing the clinical epidemiological characteristics of the novel coronavirus pneumonia and the current diagnosis and treatment schemes, as well as in-depth analyzing the disease development process and outcome trends of NCP patients to develop practical and effective clinical diagnosis and treatment schemes and provide guarantee for the rapid control of the epidemic.

Official Title
-----------------
Study for Clinical Epidemiology and Methods of Diagnosis and Treatment of Novel Coronavirus Pneumonia (NCP)

Conditions
-----------------
Novel Coronavirus Pneumonia

Intervention / Treatment
-----------------
* Combination Product: systemic treatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients confirmed with novel coronavirus pneumonia. The Diagnostic criteria refer to Pneumonitis Diagnosis and Treatment Scheme for Novel Coronavirus Infection (Trial Version 5); Exclusion Criteria: Physician judged the patient was not suitable for this clinical trial.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Combination Product: systemic treatment|Oxygen therapy, antiviral therapy, antibiotics, hormones, globulin|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| recovery | Number of patients recover from novel coronavirus pneumonia | up to 24 weeks |