Migraine and Body Composition

Study Overview
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Brief Summary
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This research is being done to look at the association between migraine and obesity.

Detailed Description
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Research into the role of inflammatory markers and other obesity related proteins and chemicals may help us understand migraine and lead to new treatment.

Official Title
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Migraine and Body Composition

Conditions
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Chronic Migraine, Migraine With and Without Aura, Healthy Controls

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Premenopausal women (18-55 years) Normal weight (BMI = 18.5 - 24.9) or obese (BMI ≥ 30) Diagnosis of episodic or chronic migraine or pain free control Exclusion Criteria: Evidence of pain disorder other than migraine (e.g. irritable bowel syndrome) Chronic conditions known to alter risk or pattern of migraine (e.g. hypothyroidism) Illnesses that may affect adipokine levels (e.g. diabetes) Clinically relevant abnormal glucose/cholesterol levels Pregnant women Potential participants who are unable to undergo MRI based on standard screening questionnaire (those with brain aneurysm or surgical clips, certain types of artificial heart valves, heart defibrillator or pacemaker, cochlear implants, eye implants, blood vessel coil, recently placed artificial joints, certain types of vascular stents, history of bullets, pellets, BBs, history of any implanted metal or device or who have worked with sheet metal in the past)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Episodic migraineurs<br>Those with migraines >2 and < 12 times per month. | |
| Chronic migraineurs<br>Those with migraines greater than 14 days per month. | |
| Controls<br>Those without headaches other than occasional hangover, cold, flu headaches. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| association between migraine and obesity - evaluate serum adipokine levels | The first aim of the proposed research is to evaluate serum adipokine levels in a clinical cohort of obese and non-obese episodic and chronic migraineurs and examine their utility as markers of the presence or absence of migraine and their relationship to headache frequency. | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| association between migraine and obesity -evaluate subcutaneous adipose tissue (SAT) and its ratio to visceral adipose tissue (VAT) | The second aim of the proposed research is to evaluate subcutaneous adipose tissue (SAT) and its ratio to visceral adipose tissue (VAT),in the same clinical cohort of migraineurs to determine if regional adipose tissue differences exist between: (1) episodic migraineurs, (2) chronic migraineurs and (3) controls, thus contributing to the migraine-obesity relationship. | five years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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migraine, episodic migraine, chronic migraine, obesity, non-obese