Effect of Different Ultrasound Doses on Median Nerve Conduction Parameters

Study Overview
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Brief Summary
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The current study investigates the effect of different doses of pulses ultrasound therapy on different nerve conduction parameters of the median nerve in healthy volunteering subjects.

Detailed Description
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In the current study, we apply pulsed ultrasound therapy on median nerves of healthy volunteer subjects, at 1 W/cm2 10% duty cycle, 3 W/cm2 10% duty cycle, 1 W/cm2 50% duty cycle, and 3 w/cm2 50% duty cycle. Parameters of median nerve conduction study, Latency, amplitude, area, duration and forearm NCV are recorded before and after application of ultrasound therapy.

Official Title
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Effect of Non-thermal Parameters of Ultrasound on Median Motor Nerve Conduction Velocity.

Conditions
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Entrapment Neuropathies

Intervention / Treatment
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* Device: Pulsed Ultrasound Therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 120 hands of 60 subjects of both genders with age range 18: 24 years. Subjects assigned will be apparently healthy subjects with no neurological or neuromuscular history affecting the upper limb. Exclusion Criteria: Peripheral polyneuropathy. Diabetes mellitus. Previous surgeries or median and/or ulnar nerve release. Cervical radiculopathy. Median or ulnar entrapment neuropathies. Previous or current pregnancies.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 24 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Four groups; First group receives pulsed US 1 W/cm2 10% duty cycle. Second group receives pulsed US 1 W/cm2 50% duty cycle. Third group receives pulsed US 3 W/cm2 10% duty cycle. Fourth group receives pulsed US 3 W/cm2 50% duty cycle.
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Low US dose<br>Pulsed US, 1 W/cm2, 10% duty cycle. | Device: Pulsed Ultrasound Therapy<br>* Ultrasound therapy is applied in the pulsed mode.<br>|
| Experimental: Intermediate US dose<br>Pulsed US, 1 W/cm2, 50% duty cycle. | Device: Pulsed Ultrasound Therapy<br>* Ultrasound therapy is applied in the pulsed mode.<br>|
| Experimental: High US dose<br>Pulsed US, 3 W/cm2, 10% duty cycle. | Device: Pulsed Ultrasound Therapy<br>* Ultrasound therapy is applied in the pulsed mode.<br>|
| Experimental: Higher US dose<br>Pulsed US, 3 W/cm2, 50% duty cycle. | Device: Pulsed Ultrasound Therapy<br>* Ultrasound therapy is applied in the pulsed mode.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CMAP distal latency | msecond | Immediately after application | 
| CMAP amplitude | mV | Immediately after application | 
| CMAP duration | msecond | Immediately after application | 
| Nerve conduction study | m/sec. | Immediately after application | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pulsed Ultrasound, Nerve conduction parameters.