Generation 100: Blood Volume and Cardiac Function in Healthy Aging

Study Overview
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Brief Summary
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Hypothesis: Exercise will reduce morbidity and mortality rates in an elderly population. The extent of reduction will be intensity dependent. As part of the Generation 100 study, this sub-study project will investigate the effect of exercise on blood volume, cardiopulmonary health and heart function in healthy aging. Objective is to determine the acute effect of one endurance training session on blood volume in healthy elderly. The working hypothesis is that one interval training session increases total blood volume by 10% in healthy elderly, and that there will be no change after moderate continuous training.

Official Title
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Generation 100: How Exercise Affects Mortality and Morbidity in the Elderly: A Randomized Control Study

Conditions
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Ageing

Intervention / Treatment
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* Behavioral: high intensity interval training
* Behavioral: moderate intensity training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ability to walk at least 1km, born in 1938,1939,1940,1941 or 1942 Sufficiently good health to be able to take part in the study, as determined by the researchers Exclusion Criteria: Illness or disability that precludes exercise or hinders completion of the study Uncontrolled hypertension Symptomatic valve disease, hyper tropic cardio-myopathy or unstable angina Active cancer Test results indicating that study participation is unsafe Inclusion in other studies conflicting with participation in this one

Ages Eligible for Study
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Minimum Age: 70 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: high intensity interval training<br>one interval training session with 1 x 4 and 4 x 4 minutes interval training at 90-95% of peak heart rate | Behavioral: high intensity interval training<br> <br> Behavioral: moderate intensity training<br> <br> |
| Active Comparator: moderate intensity training<br>45 minutes of moderate continuous training at 75% of maximal heart rate | Behavioral: high intensity interval training<br> <br> Behavioral: moderate intensity training<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| total blood volume | carbon monoxide-rebreathing spirometry (Bayreuth, Germany) | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hemoglobin volume | carbon monoxide-rebreathing spirometry (Bayreuth, Germany) | 24 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Exercise, Elderly, Blood volume, Hemoglobin