Technology Assisted Rehabilitation for Upper Limb Function in Myotonic Dystrophy Type 1

Study Overview
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Brief Summary
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Myotonic Dystrophy type 1 (DM1) is a genetic multisystem disease causing muscle weakness and myotonia. As a result, upper limb function might become impaired. There are little research regarding rehabilitation and exercise for upper limb function in DM1. It is known from research on lower limb function in DM1 and other muscular dystrophies, that there are possibilities to improve function also in these deteriorating diseases. In this single subject experimental design study, 6-10 adults with DM1, who are at an inpatient rehabilitation center, will get intensive, but personally adapted senso- and robot assisted rehabilitation for arm- and hand function with Tyromotion Amadeo and Armeo Senso. These devices have previously been used in rehabilitation research for other neurological conditions. The participants will be followed up, and evaluated at a weekly basis, using video consultations. Fine motor skill dexterity test (9HPT) and the Nut and Bolt test will be used, and active range of motion (ROM) and muscle strenght and movement of upper limb will be measured. Furthermore, patient reported outcome measures (PROMS) on hand impairment and myotonia will be used, all with purpose to evaluate upper limb function.

Official Title
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Technology Assisted Rehabilitation for Upper Limb Function in Myotonic Dystrophy Type 1

Conditions
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Myotonic Dystrophy Type 1 (DM1)

Intervention / Treatment
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* Device: Tyromotion Amadeo and Armeo Senso


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Granted rehabilitation at Vikersund Rehabilitation center Genetical confirmed myotonic dystrophy diagnosis MIRS score between 2-5 Exclusion Criteria: MIRS score on 1 Reduced Cognitive function and unable to participate in technological rehabilitation and digital evaluation

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: Single subject experimental design (SSED) study
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Technorehab<br>Rehabilitation using Tyromotion Amadeo and Armeo Senso | Device: Tyromotion Amadeo and Armeo Senso<br>* Robot assisted rehabilitation for arm- and hand function with Tyromotion Amadeo and Armeo Senso<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fine motor skill dexterity test, 9 hole peg test (9HPT) | Motor skill test | 1-3 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Range of motion (ROM) | Measure of ROM in upper limb joints | 5-10 minutes | 
| Nut and Bolt test | Motor skill test | 5 minutes | 
| Hand strength | Measured by Jamar digital dynamometer | 5 minutes | 
| Pinch Gauge | Finger strength measures by Jamar digital pinch gauge | 5 minutes |