Comparison of ONSD and rSO2 Measurements Between General and Spinal Anesthesia in C-Section

Study Overview
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Brief Summary
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General anesthesia and regional anesthesia can be chosen in cesarean operations. Endotracheal intubation and mechanical ventilation are components of general anesthesia. Endotracheal intubation has been shown to cause increased intracranial pressure. There is not enough information about the effect of spinal anesthesia on intracranial pressure during cesarean operations. Increased intracranial pressure can cause neurological complications by disrupting brain perfusion. For this reason, the investigators think that the safe anesthesia method should be determined especially in pregnant patients who are at risk of increased intracranial pressure.

Official Title
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Comparison of Optic Nerve Sheath Diameter and Cerebral Regional Oxygen Saturation Measurements Between General and Spinal Anesthesia Applications in C-Section

Conditions
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Intracranial Pressure Increase

Intervention / Treatment
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* Other: Optic Nerve Sheath Diameter Measurement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Undergoing elective c-section operation Age between 18-49 ASA I-II Gestational week ≥ 36 Exclusion Criteria: Ophthalmologic disease and optic nerve pathology Increased intracranial pressure History of cerebrovascular disease Cases where spinal anesthesia is contraindicated Emergency cesarean category level 1

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 49 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Group General Anesthesia<br>C-Section under general anesthesia | Other: Optic Nerve Sheath Diameter Measurement<br>* The change in intracranial pressure via optic nerve sheath diameter measurement<br>|
| Experimental: Grup Spinal Anesthesia<br>C-Section under spinal anesthesia | Other: Optic Nerve Sheath Diameter Measurement<br>* The change in intracranial pressure via optic nerve sheath diameter measurement<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Optic Nerve Sheath Diameter | The change in intracranial pressure via optic nerve sheath diameter measurement during c-section among 5 time point. | Throughout the surgery | 
| Change in regional cerebral oxygen saturation | The change in regional cerebral oxygen saturation during c-section among 5 time point. | Throughout the surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Perioperative Hemodynamic Parameters | Mean arterial pressure in mmHg | Throughout the surgery | 
| Perioperative Hemodynamic Parameters | Heart rate beat per minute | Throughout the surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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optic nerve sheath diameter, intracranial pressure, intraabdominal pressure, cerebral regional oxygen saturation, c-section