Aripiprazole and Topiramate on Free-Choice Alcohol Use

Study Overview
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Brief Summary
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The current study investigates the effects of two potential alcohol treatment medications on drinking in a laboratory setting. Aripiprazole (APZ), effects dopamine and serotonin receptors with fewer limiting side effects seen with other atypical antipsychotics. Topiramate (TPMT), an antiepileptic, affects glutamate and GABA-A receptors and shows promise in reducing heavy drinking. Few studies have used two medications with such a diverse combination of actions to examine a potential synergistic effect on reducing alcohol consumption. The primary aims are to: determine if APZ and TPMT are each more effective than placebo, and the combination of APZ and TPMT is more effective than either drug alone or placebo, in reducing alcohol use in non-treatment seeking alcohol dependent subjects in a laboratory based alcohol self-administration experiment (ASAE) examine a hypothesized dose-response for three doses of APZ (0, 7.5 mg/d and 15 mg/d) along with three doses of TPMT (0, 100mg/d and 200mg/d) examine the putative mechanisms of action of APZ, TPMT alone and together on craving, subjective stimulation, candidate gene influences and other behavioral effects associated with alcohol consumption establish the safety of giving APZ and TPMT together. Non-treatment seeking, alcohol dependent Participants (N=216) will be recruited from the community and randomly assigned to one of the 9 cells. Subjects drinking and safety is monitored over a 5-week titration to their target dose, leading to an in-laboratory alcohol self administration session, during which clinical and behavioral effects are assessed during access to alcohol. A 1 month follow-up assesses adverse events and drinking.

Detailed Description
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Due to the modest effect of current pharmacotherapies, more effective treatments must be developed to optimally treat alcohol dependent patients. Treatments combining pharmacotherapies with different mechanisms of action may better address the diverse neurobiology of alcohol and the heterogeneity of alcoholics. However, little is known about how medication may affect behavior to reduce drinking. Aripiprazole (APZ), a partial dopamine agonist, affects dopamine and serotonin receptors without the limiting side effects seen with other atypical antipsychotics. Dopamine mediates reward based drinking and craving. Topiramate (TPMT), an antiepileptic, affects glutamate and GABA-A receptors and shows promise in reducing heavy drinking. Glutamate and GABA may mediate relief-based drinking and protracted withdrawal. Despite strong evidence that multiple neurotransmitters contribute to alcoholism, few studies have used two medications with such a diverse combination of actions to examine a potential synergistic effect on reducing alcohol consumption. The present study will recruit 216 healthy, alcohol-dependent volunteers who are not currently seeking treatment for their alcohol dependence to learn more about how these medications may work. The primary aims are to: (1) determine if APZ and TPMT are each more effective than placebo, and the combination of APZ and TPMT is more effective than either drug alone or placebo, in reducing alcohol use in non-treatment seeking alcohol dependent subjects in an alcohol self administration experiment (ASAE); (2) examine a hypothesized dose-response for three doses of APZ (0, 7.5mg/d and 15 mg/d) and three doses of TPMT (0, 100mg/d, 200mg/d); (3) examine the putative mechanisms of action of APZ, TPMT alone and together on craving, subjective stimulation, candidate gene influences and other behavioral effects associated with alcohol consumption; and (4) establish the safety of giving APZ and TPMT together. We will use of a 3 X 3 drug (7.5mg, 15mg APZ vs. placebo) by drug (100mg, 200mg TPMT vs. placebo) between-subjects factorial design. Participants are randomly assigned to one of 9 cells. Subjects drinking and safety is monitored over a 5-week titration to their target dose, leading to an in-laboratory alcohol self administration session, during which clinical and behavioral effects are assessed during access to alcohol. A 1 month follow-up assesses adverse events and drinking. The long term objectives of this research are to improve medications available for alcoholism treatment and inform research and theory on the mechanisms of action of such medications.

Official Title
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Aripiprazole and Topiramate on Free-Choice Alcohol Use

Conditions
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Alcohol Dependence

Intervention / Treatment
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* Drug: Double Placebo
* Drug: Aripiprazole 15, placebo
* Drug: Aripiprazole 7.5, Placebo
* Drug: Topiramate 100, Placebo
* Drug: Topiramate 200, Placebo
* Drug: Topiramate 100, Aripiprazole 15
* Drug: Topiramate 100, Aripiprazole 7.5
* Drug: Topiramate 100, Aripiprazole 15mg
* Drug: Topiramate 200, Aripiprazole 7.5mg
* Drug: Topiramate 200, Aripiprazole 15


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: must be non-treatment seeking for alcohol dependence a current DSM-IV-TR diagnosis of alcohol dependence supported by the Structured Clinical Interview for DSM-IV-TR Axis I Disorders Patient Edition (SCID-I/P a minimum of ≥ 35drinks a week for men or ≥ 28 or more drinks a week for women must be suitable for outpatient treatment able to read English at an eighth grade level, understand their rights as provided by the informed consent, and be willing to sign an informed consent to participate in the study be between 21 and 65 years on age (inclusive) provide evidence of stable residence in the two months prior to enrollment and no plans to move for the next four months provide a verifiable contact person prior to randomization be in generally good health as determined by the physical exam, medical history, ECG and laboratory tests have a Body Mass Index >18kg/m2 and < 33 kg/m2 if female, must be postmenopausal practicing an effective method of birth control, have negative pregnancy tests at randomization and before the ASAE; be willing to be adherent to medication dosing. Exclusion Criteria: clinically significant medical abnormalities (i.e. ECG, hematological assessment, bilirubin > 150% of the upper limit of normal or ALT or AST elevations >300% the upper limit of normal, biochemistry including urinalysis, electrolytes,). (Persons with medical conditions that are adequately controlled by their primary care physician will not be excluded.) have significant alcohol withdrawal symptoms (clinical institute withdrawal assessment for alcohol revised (CIWA-Ar) >10 a history of suicide; history of renal impairment or nephrolithiasis; creatinine clearance of <60 dl/minute pregnant or lactating or not using an adequate form of birth control taking other medications that may have an effect on alcohol consumption or are carbonic anhydrase inhibitors clinically significant diseases of the gastrointestinal system or active liver disease; subjects compelled to receive treatment to avoid imprisonment or loss of employment previously with a history of adverse reaction or hypersensitivity to either Topiramate or aripiprazole have a diagnosis of with schizophrenia or bipolar disorder and/or taking antipsychotics and other drugs that inhibit CYP3A4 or CYP2D6 isoenzymes history of seizures (e.g. epilepsy) patients currently diagnosed with a substance dependence diagnosis other than alcohol or tobacco patients who have participated in any clinical trial with an investigational agent within the past 30 days individuals with a reasonable expectation of being institutionalized during the course of the trial or pending legal charges pregnant or nursing women.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Double Placebo<br>Placebo, Placebo | Drug: Double Placebo<br>* 1 capsule daily<br>|
| Experimental: Aripiprazole 15, Placebo<br>15 mg Aripiprazole, Placebo | Drug: Aripiprazole 15, placebo<br>* 15 mg Aripiprazole daily plus placebo daily<br>* Other names: Abilify, Topamax;|
| Experimental: Aripiprazole 7.5, Placebo<br>Aripiprazole 7.5 mg daily plus Placebo daily | Drug: Aripiprazole 7.5, Placebo<br>* Aripiprazole 7.5 mg daily plus Placebo daily<br>|
| Experimental: Topiramate 100mg, Placebo<br>Topiramate 100 mg daily plus Placebo daily | Drug: Topiramate 100, Placebo<br>* Topiramate 100 mg daily plus Placebo daily<br>|
| Experimental: Topiramate 200, Placebo<br>Topiramate 200 mg daily plus Placebo daily | Drug: Topiramate 200, Placebo<br>* Topiramate 200 mg daily plus Placebo daily<br>|
| Experimental: Topiramate 100, Aripiprazole 5<br>Topiramate 100 daily plus, Aripiprazole 5mg daily | Drug: Topiramate 100, Aripiprazole 15<br>* Topiramate 100 mg daily plus Aripiprazole 15mg daily<br>* Other names: Abilify, Topamax;Drug: Topiramate 100, Aripiprazole 15mg<br>* Topiramate 100 mg daily plus Aripiprazole 15mg daily<br>* Other names: Topamax;|
| Experimental: Topiramate 200, Aripiprazole 15<br>Topiramate 200 mg daily plus Aripiprazole 15mg daily | Drug: Topiramate 200, Aripiprazole 15<br>* Topiramate 200mg daily plus Aripiprazole 15mg daily<br>* Other names: Topamax;|
| Experimental: Topiramate 100, Aripiprazole 7.5<br>Topiramate 100 mg daily, Aripiprazole 7.5 mg daily | Drug: Topiramate 100, Aripiprazole 7.5<br>* Topiramate 100 mg daily plus Aripiprazole 7.5mg daily<br>|
| Experimental: Topiramate 200, Aripiprazole 7.5mg<br>Topiramate 200 mg daily plus Aripiprazole 7.5mg daily | Drug: Topiramate 200, Aripiprazole 7.5mg<br>* Topiramate 200 mg daily plus Aripiprazole 7.5mg daily<br>* Other names: Topamax;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of alcoholic drinks consumed in a laboratory setting |  | 90 minutes | 
| Safety and tolerability of the medications singly and in combination, compared to placebo |  | 4 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Drinks consumed during the medication titration period |  | 4 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Alcohol dependence, alcohol abuse, topiramate, aripiprazole