The Relationship Between Blood Glucose and Satiety Ratings

Study Overview
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Brief Summary
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Participants will be given a drink (and no drink for one of the treatments) prior to a pizza dinner. Ratings on satiety, appetite and desire to eat will be asked with the use of a questionnaire. Blood glucose will also be measured. One hour after the drink, participants will be given a pizza and can eat as much as they want. The pizza remaining will be weighed.

Detailed Description
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Each participant will receive all three treatments on separate occasions in random order (separated by a week). The three treatments include control (no supplement), carbohydrates - protein (Generation UCAN supplement, 250ml, 10% solution) and carbohydrates alone (Mirexus PhytoSpherix, 250ml, 10% solution). Participants will report to the lab between 4-5 pm and 4 hours after their last meal on day they have not exercised. Participants will record food intake the day of the first experiment and will be asked to replicate both type and quantity for subsequent visits. Upon arrival at the lab, baseline measures (blood glucose as well as rating of satiety ratings, appetite and desire to eat (10-point visual analogue scale). Then the treatment will be given and all the aforementioned variables will be remeasured at 15, 30, 45 and 60 minutes post drink. At 65 minutes, participants will be provided with an ad libitum pizza meal. Participants will be told to eat until they are comfortably full (Bellissimo et al., 2008). The pizza provided will be weighed initially and once the participant is done eating and has left the lab, the remaining pizza will be weighed and recorded. The pizza will be a cheese only pizza to minimize any difference in energy intake due to the location of additional items placed on the pizza. Participants will not be told the true purpose of this experiment, instead they will be told that the pizza meal is a reward for participating in the study. Later, at the conclusion of the study all will be debriefed.

Official Title
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The Relationship Between Blood Glucose and Satiety Ratings

Conditions
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Satiety, Appetite

Intervention / Treatment
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* Dietary Supplement: Generation UCAN supplementation
* Dietary Supplement: Mirexus PhytoSpherix supplementation
* Behavioral: satiety ratings


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy males and females at the age of 18-40 sedentary individuals Exclusion Criteria: exercise more than twice per week does not like pizza do not eat three meals a day medications that affect eating patterns have metabolic and gastrointestinal diseases

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: control<br>no supplement will be provided on the day of the experiment | Behavioral: satiety ratings<br>* questionnaire on satiety ratings will be provided to participants 15, 30, 45 and 60 min after the drink (or no drink)<br>|
| Experimental: Generation UCAN<br>carbohydrates - protein (Generation UCAN supplement, 250ml, 10% solution) | Dietary Supplement: Generation UCAN supplementation<br>* carbohydrates - protein (Generation UCAN supplement, 250ml, 10% solution)<br>Behavioral: satiety ratings<br>* questionnaire on satiety ratings will be provided to participants 15, 30, 45 and 60 min after the drink (or no drink)<br>|
| Experimental: Mirexus PhytoSpherix<br>carbohydrates alone (Mirexus PhytoSpherix, 250ml, 10% solution) | Dietary Supplement: Mirexus PhytoSpherix supplementation<br>* carbohydrates alone (Mirexus PhytoSpherix, 250ml, 10% solution)<br>Behavioral: satiety ratings<br>* questionnaire on satiety ratings will be provided to participants 15, 30, 45 and 60 min after the drink (or no drink)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes in satiety ratings after the drink | satiety ratings will be asked with the use a 10 point visual analog scale (VAS) questionnaire, 10 being do not want to consume any more food and 1 being strong desire to consume food | 15, 30, 45, 60 min after the drink | 
| Food intake | food intake after each treatment will be measured by weighing the left over pizza slices | 90 min after the drink | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes in appetite ratings after the drink | appetite ratings will be asked with the use a 10 point visual analog scale (VAS), 10 being strong desire to consume food and 1 being no desire to consume food at all | 15, 30, 45, 60 min after the drink | 
| changes in blood glucose after the drink | blood glucose will be measured through finger pricks | 15, 30, 45, 60 min after the drink | 
| changes in desire to eat ratings | desire to eat ratings will be asked with the use a 10 point visual analog scale (VAS), 10 being no desire to eat at all and 1 being strong desire to eat | 15, 30, 45, 60 min after the drink |