Paroxysmal Positional Vertigo & Repositioning Maneuvers

Study Overview
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Brief Summary
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: Benign Paroxysmal Positional Vertigo is a condition related to vestibular system accompanied by dizziness, tinnitus and balance problems leading to increased fall risk and potential disability. Various treatment options are available including pharmacotherapy and vestibular rehabilitation with varied results

Detailed Description
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Objective: The objective of this study was to compare the efficacy of Modified Epley & Semont's maneuver with and without Betahistine for BPPV Material & Methods: The study was a single blind randomized control trail. Total number of patients were 97 as calculated by Epitool calculator. Duration of the study was of one year from 2 January 2021 to 1st January 2022. Out of a total 97 patients, 90 met the inclusion criteria. These participants were randomized by lottery method into two equal groups. Group A (control group) was receiving both maneuvers only while group B (experimental group) included participants receiving betahistine along with both maneuvers. The impact of dizziness and quality of life was measured through EQ-5D-5L questionnaire and dizziness handicap inventory (DHI) in order to analyze the effectiveness of treatments. Pre and Post treatment results were compared within group by Wilcoxon rank test and for between groups, Mann Whitney U test was performed

Official Title
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Effect of Modified Epley's & Semont's Maneuvers With or Without Beta-histine on Benign Paroxysmal Positional Vertigo: A Randomized Control Trail

Conditions
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Benign Paroxysmal Positional Vertigo

Intervention / Treatment
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* Other: Modified eply & Semont maneuver
* Other: betahistine & Modified eply & Semont maneuver


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age between 18-60 positive modified Dix Hil pike test repetitive vertigo spells affecting activities of daily livings (ADLs) Exclusion Criteria: any cervical spine problem vertigo due to central disease tumors systemic disease cardiac disease Parkinson disease bed bound patients

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: 2 groups , group A contro group and group B experimental group
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group A<br>Control group | Other: Modified eply & Semont maneuver<br>* repositioning maneauvers<br>|
| Experimental: group B<br>experimental group | Other: betahistine & Modified eply & Semont maneuver<br>* antihistamine plus repositioning maneuvers<br>* Other names: Modified eply & Semont maneuver;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| DHI | dizziness handicap inventery | 1 month | 
| EQ-5D-5L | quality of life | 1 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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BPPV