Catheter Associated Asymptomatic Thrombosis in Intensive Care Unit

Study Overview
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Brief Summary
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This study aims to describe the incidence of catheter-related and non-catheter-related thrombosis in a population of adults in ICU and to assess its correlation with alteration of coagulation parameters.

Detailed Description
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Central venous catheter (CVC) is now indispensable in the monitoring and care of patients in intensive care (ICU). Unfortunately, one of the complications of its positioning is catheter-related thrombosis (CRT) and its consequences. Despite the widespread use of CVC and the extensive literature describing its complications, areas of uncertainty regarding the onset, treatment and prevention of CRT persist, especially with regard to asymptomatic thrombosis. This study aims to describe the incidence of catheter-related and non-catheter-related thrombosis in a population of adults in ICU and to assess its correlation with alteration of coagulation parameters. The main objective of this study is to assess the proportion of patients developing CRT (proportion) and the incidence of CRT (rate expressed in catheter events/days) in patients in ICU.

Official Title
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Prospective Cohort Study on Catheter Associated Asymptomatic Thrombosis in Intensive Care Unit

Conditions
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Central Venous Catheters, Central Venous Catheter Thrombosis, Thrombosis, Venous, Intensive Care Unit

Intervention / Treatment
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* Diagnostic Test: ultrasound


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients over the age of 18 admitted to intensive care who have for clinical reasons need to place a central venous catheter signing of informed consent Exclusion Criteria: patients under 18 years of age Known cancer status Congenital thrombophilia

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: ultrasound|ultrasound of the central veins of the neck and chest and a (compression ultra-sound) CUS of the femoral veins will be performed bilaterally|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of patients developing Catheter related thrombosis and Incidence of CRT in patients in ICU | The main objective of this study is to assess the proportion of patients developing CRT (proportion) and the incidence of CRT (rate expressed in catheter events/days) in patients in ICU. | Until CVC removal | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of various types of thrombotic apposition | The proportion of various types of thrombotic apposition | Until CVC removal | 
| Deep venous thrombosis (DVT) proportion and Incidence | The proportion of patients developing DVT and the incidence of catheter-related DVT (rate) in patients in ICU carrying CVC. | Until CVC removal | 
| the association of thrombosis with alterations of hemocoagulative parameters | the association of thrombosis with alterations of hemocoagulative parameters | Until CVC removal | 
| describe the clinical measures that have been taken following the diagnosis of CRT.describe the clinical measures that have been taken following the diagnosis of CRT. | describe the clinical measures that have been taken following the diagnosis of CRT. | Until CVC removal |