linjc16/ctgov huggingface dataset:
Comparison of N2O Inhalation and Ketamine in Pediatric PSA

Study Overview
=================
Brief Summary
-----------------
Ketamine provides effective and relatively safe sedation analgesia for primary closure of lacerated pediatric patients However, deep sedation and adverse effects suggest the opportunity to develop alternative strategies We compared the efficacy and adverse effects of ketamine to those of N2O gas for analgesia and anxiolysis during primary repair of lacerated pediatric patients

Detailed Description
-----------------
There were 32 children who were randomly assigned Recovery times were markedly shorter in the N2O group compared with those in the ketamine group (median, 0.0 min (interquartile range [IQR], 0.0-4.0 min) vs. median, 21.5 min (IQR, 12.5-37.5 min), N2O vs. ketamine, respectively, p < 0.05) Sedation levels were deeper in the ketamine group than in the N2O group, but pain scales were comparable between groups No difference was observed in the satisfaction scores by physicians, parents, or nurses. N2O inhalation was preferable to injectable ketamine for pediatric patients because it is safe, allows for a faster recovery, maintains sufficient sedation time, and does not induce unnecessarily deep sedation

Official Title
-----------------
Comparison of N2O Inhalation and Ketamine IV Injection for Sedation in the Treatment of Laceration of Pediatric Patients.

Conditions
-----------------
Moderate Sedation, Laceration

Intervention / Treatment
-----------------
* Drug: N2O gas vs ketamine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pediatric patients with lacerated wound Exclusion Criteria: Contraindication of ketamine or N2O gas A wound around eye and mouth

Ages Eligible for Study
-----------------
Minimum Age: 36 Months
Maximum Age: 10 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Ketamine<br>Ketamine 2mg/kg IV | Drug: N2O gas vs ketamine<br>* Ketamine : 2mg/kg IV N2O : 50%-70% N2O gas<br>|
| Experimental: N2O gas<br>50%-70% N2O gas inhalation | Drug: N2O gas vs ketamine<br>* Ketamine : 2mg/kg IV N2O : 50%-70% N2O gas<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The recovery time (from completion of laceration repair to recovery of mental state) |  | before discharge | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sedation scale |  | before discharge | 
| pain scale |  | before discharge | 
| Side effects |  | during procedure and bedore discharge and 1day after discharge | 
| Satisfaction of parents and clinicians |  | before discharge |
High Sensitivity Troponin T Levels Following DC Cardioversion for Atrial Fibrillation / Atrial Flutter

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine if there is a rise in serum high sensitivity troponin T (a marker for heart muscle injury) following a direct current cardioversion (shock therapy) used for patients with atrial fibrillation. This will help us determine if direct current cardioversion results in damage to the heart muscles in a sufficient amount to cause a rise in high sensitivity troponin T.

Detailed Description
-----------------
High sensitivity Troponin T is a relatively new biomarker that is highly sensitive and specific for myocardial injury. Its widespread use has helped in the determination and investigation for myocardial ischemia in patients. Previous studies have shown a rise in creatine kinase (CK) and the more specific creatine kinase-MB isoenzyme (CKMB) after DC cardioversion. Studies on the earlier generation troponin T found that the levels don't rise or rise only minimally after DC cardioversion. The high sensitivity troponin T has never been studied in the setting of DC cardioversion.

Official Title
-----------------
High Sensitivity Troponin T Levels Following Elective External Direct Current Cardioversion for Atrial Fibrillation / Atrial Flutter

Conditions
-----------------
Atrial Fibrillation, Atrial Flutter

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with atrial fibrillation / atrial flutter attending for direct current external cardioversion Age 18 or older Exclusion Criteria: Myocardial infarction within the last 6 weeks Coronary artery bypass grafting, percutaneous coronary intervention or any other invasive cardiac procedure within the last 6 weeks

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| DC Cardioversion<br>Patients undergoing DC cardioversion | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| High Sensitivity Troponin T levels pre and 6 hours post cardioversion |  | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Creatine Kinase levels pre and 6 hours post cardioversion |  | 1 year | 
| B-type Natriuretic Peptide (BNP) levels pre and 6 hours post cardioversion |  | 1 year | 
| Neutrophil Gelatinase-associated Lipocalin (NGAL) levels pre and 6 hours post cardioversion |  | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cardioversion, High Sensitivity Troponin T (Hs-Trop T), Brain Natriuretic Peptide (BNP), Neutrophil Gelatinase-associated Lipocalin (NGAL)
Assessment of a Health Informatics System on Insulin-treated Diabetic Patients

Study Overview
=================
Brief Summary
-----------------
Modern medicine provides many solutions that are intended to help control the patient's blood glucose level: insulin and other medications to lower it, glucose tablets or glucagone to raise it when it gets dangerously low, glucometers to quickly measure the blood glucose level, pumps and pens to inject insulin or other injectable medicine, etc.The objective of this trial is proving the concept and the feasibility of using a medical informatics system comprised of computer hardware, software and a smartphone application to achieve better outcomes.

Official Title
-----------------
Assessment of a Health Informatics System on Insulin-treated Diabetic Patients

Conditions
-----------------
Type 1 or 2 Diabetics

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Type 1 or 2 diabetics diagnosed at least 12 months prior to study enrollment. Treated with insulin (basal only or basal + bolus) for at least 6 months prior to study enroment. HbA1c lower than 12% With or without other anti-diabetic drugs. 18-80 years of age. Male or female. Own an Android phone. Able to handle mobile applications, technology-friendly Able and willing to understand and comply with the study procedures. Provide signed written and informed consent form prior to enrolment in the study. Exclusion Criteria: Using an insulin pump. Pregnant or planning to be pregnant within the period of the study. Active substance abuse. Psychosis or schizophrenia under active care. Uncorrected severe hearing or visual impairment. Any other condition that is not acceptable to the investigator.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Diabetes Management System , blood glucose<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recommendation accuracy | Recommendation accuracy: over 80% correspondence between the corrective actions recommended by the system and the corrective actions decided upon by the physician. | three months |
An Open-Label Study of Serum Testosterone Levels in Non-dosed Females After Secondary Exposure to Testosterone Gel 1.62% Applied to the Upper Arms and Shoulders and Use of a T-shirt Barrier

Study Overview
=================
Brief Summary
-----------------
Single-center, single dose, open-label study in healthy male and female volunteers to further characterize the transfer potential of Testosterone Gel 1.62% formulation.

Detailed Description
-----------------
Single-center, single dose, open-label study in 12 healthy male and 12 healthy female volunteers to further characterize the transfer potential of Testosterone Gel 1.62% formulation.

Official Title
-----------------
An Open-Label Study of Serum Testosterone Levels in Non-dosed Females After Secondary Exposure to Testosterone Gel 1.62% Applied to the Upper Arms and Shoulders and Use of a T-shirt Barrier

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Drug: Testosterone Gel 1.62%


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria BMI between 20-35 kg/m^2 inclusive. Exclusion Criteria Males: history, current or suspected prostate or breast cancer. Females: pregnant or lactating.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br> | Drug: Testosterone Gel 1.62%<br>* 5 grams<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximum Plasma Concentration observed (Cmax) | Maximum plasma concentration observed (Cmax) of total testosterone | Up to 5 days | 
| Area Under the Plasma Concentration-time Curve (AUC) | Area under the plasma concentration-time curve (AUC) of total testosterone | Up to 5 days | 
| Average Plasma Concentration observed (Cav) | Average Plasma Concentration observed (Cav) of total testosterone | Up to 5 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
testosterone,, Pharmacokinetics, replacement,, therapy
Foreign Body Removal With the Assistance of Ultrasound Guidance and Methylene Blue Staining in Children

Study Overview
=================
Brief Summary
-----------------
Soft-tissue foreign bodies (FB) are very commonly observed in pediatric emergency departments. Some are metallic and can be diagnosed easily via X-ray radiography, whereas others are radiolucent and are hence less easily diagnosed. Not all FB can be removed effectively, even via open surgery and C-arm guidance. This deficiency may potentially be addressed through the ultrasound (US) skills instrument, which is increasingly popular and is convenient for use in the operation room. In the current study, we evaluated the efficiency of FB removal with the assistance of US and methylene blue (MB) staining.

Official Title
-----------------
Foreign Body Removal With the Assistance of Ultrasound Guidance and Methylene Blue Staining

Conditions
-----------------
Ultrasound, Foreign Bodies

Intervention / Treatment
-----------------
* Procedure: US guidance and MB staining


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosed with soft-tissue foreign body Must have complete clinical data Exclusion Criteria: Had other injuries Presented with more than 3 pieces foreign bodies

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Ultrasound<br>Ultrasound guidance and methylene blue staining | Procedure: US guidance and MB staining<br>* Ultrasound guidance and methylene blue staining<br>|
| Active Comparator: Open surgery<br>Open surgery without ultrasound guidance and methylene blue staining | Procedure: US guidance and MB staining<br>* Ultrasound guidance and methylene blue staining<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Surgery time | Time from incision made to incision closure | Surgery end time | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood loss | The blood loss of all the surgery time | Surgery end time |
Health After Covid-19 in Tyrol

Study Overview
=================
Brief Summary
-----------------
The aim of the regional online questionnaire is to better understand the pattern of acute infection and the time of recovery of various symptoms.

Detailed Description
-----------------
The ongoing COVID-19 pandemic considerably increases the demand for healthcare and raises concerns on longterm disease outcome. Accordingly, to increase the knowledge on recovery from symptoms of acute infection and longterm health effects, a regional COVID-19 online survey on the health-status after infection will be performed. This cross-sectional anonymous online survey is initiated and conducted by an interdisciplinary study team of the Medical University of Innsbruck, Austria. For each participant, demographic characteristics (e.g. age, gender, district affiliation, profession), medical history (presence of comorbidities, medication), diagnosis of COVID-19, symptoms and their duration, treatments and special conditions will be collected. The aim of the survey is to better understand the pattern of acute infection and the time of recovery of various symptoms. The anonymous online survey is open to individuals after COVID-19 infection (proven by SARS-Cov-2 positive PCR or antibody test) over the age of 16 and living in Tyrol (Western-Austria). The survey takes around 30 minutes to complete.

Official Title
-----------------
Health After COVID-19 in the European Region Tyrol - South Tyrol

Conditions
-----------------
COVID-19

Intervention / Treatment
-----------------
* Other: online survey


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: status post COVID-19 infection, defined by a positive SARS-Cov-2 PCR or antibody test age ≥ 16years resident in Tyrol (Austria) Exclusion Criteria:

Ages Eligible for Study
-----------------
Minimum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: online survey|We invite volunteers after COVID-19 to participate in an online survey.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Population based data on spectrum and recovery from COVID-19 symptoms | Percentage of patients manifesting ongoing symptoms after 2 weeks of infection. | two weeks after infection | 
| Population based data on spectrum and recovery from COVID-19 symptoms | Spectrum of symptoms at onset and at end of disease. | up to 24 weeks | 
| Predictors of recovery. | Identification of symptoms or comorbidities associated with Long-Covid-19. | up to 24 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
long term sequelae
Impact of Postanesthesia Care Unit Delirium on Postoperative Quality of Recovery

Study Overview
=================
Brief Summary
-----------------
Postanesthesia care unit (PACU) delirium is subtype of postoperative delirium that occurs early after anesthesia and surgery during the recovery period. The consequences of PACU delirium have not been investigated thoroughly. So far it is unknown, whether patients with PACU delirium experience impaired postoperative quality of recovery. The aim of this observational study is to assess the impact of PACU delirium on quality of recovery 24 hours after general anesthesia for elective non-cardiac surgery.

Official Title
-----------------
Impact of Postanesthesia Care Unit Delirium on Postoperative Quality of Recovery

Conditions
-----------------
Postoperative Neurocognitive Disorders, Delirium, Postoperative Recovery, Anesthesia

Intervention / Treatment
-----------------
* Other: questionnaire


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: elective non-cardiac surgery general anesthesia fluency in German Exclusion Criteria: expected postoperative ICU stay

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: questionnaire|assessment of postoperative quality of recovery with the QoR-15|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative quality of recovery | patient-reported quality of recovery after surgery and anesthesia with the QoR-15, ranging from 0 (poor recovery) to 150 (excellent recovery) | 24 hours postoperatively |
Detection of Visual-Auditory Reaction Rates in Individuals With Type 2 Diabetes

Study Overview
=================
Brief Summary
-----------------
Background: The primary purpose of our study was to understand the damage in the peripheral nerves of patients with diabetes and to determine the change in patients' reaction rates and perceptions by the age groups, duration of diabetes, fasting plasma glucose and HbA1c values, and compare these with those of the healthy individuals. Methods: This study was carried out at the Baskent University Hospital Endocrinology and Metabolic Diseases Outpatient Clinic. A total of 64 patients diagnosed with type 2 diabetes and 64 healthy controls were included in the study. Finger tapping, visual, and auditory reaction time tests were performed on the subjects, respectively. The subjects' fasting plasma glucose and HbA1c levels, and the duration of their diabetes were recorded. Analyses were performed using the SPSS version 25. Differences were considered statistically significant when the p-value is <0.05.

Official Title
-----------------
Detection of Visual-Auditory Reaction Rates in Individuals With Type 2 Diabetes

Conditions
-----------------
Diabetes Mellitus, Type 2, Cognitive Dysfunction, Nerve Damage

Intervention / Treatment
-----------------
* Device: recation time test


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Right-handed individuals Must be between 18-65 ages Must be Type 2 diabetics at least 6 months (for patient group) Exclusion Criteria: use of alcohol-drug or similar substances, the use of any medication that may affect neurological functions, having color blindness, retinopathy, neurological disease, cancer, depression, a recent history of surgery, rheumatoid arthritis, osteoarthritis, and advanced osteoarthritis.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| DIABETES<br>Visual, finger tapping and auditory tests were performed regularly. The subjects' fasting plasma glucose and HbA1c levels, and the duration of their diabetes were recorded. | Device: recation time test<br>* visual-finger tapping and auditory reaction time tests<br>|
| CONTROL<br>Visual, finger tapping and auditory tests were performed regularly. The subjects' fasting plasma glucose and HbA1c levels were recorded. | Device: recation time test<br>* visual-finger tapping and auditory reaction time tests<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Finger tap, visual and auditory reaction test data within 10 seconds | Reaction times | April-September 2021 |
Intra-articular Magnesium Sulfate for Tmj Dysfunction

Study Overview
=================
Brief Summary
-----------------
mixing the magnesium sulfate with dextrose for management of tmj pain will be studied using intra-articular injection of the solution

Official Title
-----------------
Effect of Magnesium Sulfate on Pain and Clicking Sound on Patients With Temporomandibular Joint Dysfunction

Conditions
-----------------
Temporomandibular Joint Disorders, Temporomandibular Sprain

Intervention / Treatment
-----------------
* Drug: intra-articular injection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy females-no treatment received within the last 6 months-accept treatment protocol Exclusion Criteria: unco-operative patients-patients with auto-immune diseases-patients diagnosed with arthritis

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: intra-articular injection<br>intra-articular injection with magnesium sulfate at weekly interval for four weeks | Drug: intra-articular injection<br>* intra-articular injection with magnesium sulfate with four injections at weekly intervals<br>* Other names: prolotherapy;|
| Placebo Comparator: control<br>intra-articular injection with saline | Drug: intra-articular injection<br>* intra-articular injection with magnesium sulfate with four injections at weekly intervals<br>* Other names: prolotherapy;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| estimation of pain: Visual Analog Scale | Visual Analog Scale pain measurement with 0 indicates no pain and 100 the maximum pain felt ever | one year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
tmj pain