Comparison of Propofol and Sevoflurane as Maintaining Anesthetics During General Anesthesia of Cesarean Section

Study Overview
=================
Brief Summary
-----------------
Sevoflurane and propofol are the most popular drug choices for maintenance of general anaesthesia for caesarean section. However, effects of these two anesthetics on maternal and fetal outcomes after caesarean section haven't been compared directly. The aim of this study is to compare the effects of sevoflurane and propofol as maintenance of general anesthesia, and to try to determine which anesthetic is better for maternal and fetal outcomes after caesarean section.

Detailed Description
-----------------
General anaesthesia is mostly performed for emergency grade 1 caesarean section and due to a lack of time to apply a neuraxial anaesthesia technique. Rapid sequence induction using propofol and rocuronium should become the standard for general anaesthesia in the obstetric patient. Both sevoflurane and propofol are considered to be appropriate for the maintenance of general anaesthesia during caesarean section. However, effects of these two anesthetics on maternal and fetal outcomes after caesarean section haven't been compared directly in the past. And for most anaesthesiologists, the clinical experience with general anaesthesia for caesarean section is very low. This study is to compare the effects of sevoflurane and propofol as maintenance of general anesthesia.

Official Title
-----------------
Comparison of Effects of Propofol and Sevoflurane as Maintaining Anesthetics During General Anesthesia on Maternal and Fetal Outcomes After Cesarean Section

Conditions
-----------------
Sevoflurane, Propofol, Cesarean Section

Intervention / Treatment
-----------------
* Drug: propofol
* Drug: sevoflurane


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: ASAⅠor Ⅱ parturients (aged 18-35 years) undergoing elective caesarean section Exclusion Criteria: Parturients with severe pregnancy complications

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: propofol<br> | Drug: propofol<br>* Using propofol and remifentanil as maintenance of general anesthesia during caesarean section.<br>|
| Experimental: sevoflurane<br> | Drug: sevoflurane<br>* Using sevoflurane and remifentanil as maintenance of general anesthesia during caesarean section.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maternal hospital stay | Maternal hospital stay time | Before dismissed from hospital | 
| Maternal mortality | Maternal mortality in hospital | Before dismissed from hospital | 
| Newborn hospital stay | Newborn hospital stay time | Before dismissed from hospital | 
| Newborn mortality | Newborn mortality in hospital | Before dismissed from hospital |