The Effects of Rhus Coriaria L. on Body Weight

Study Overview
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Brief Summary
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The aim of this study is to evaluate the effects of Rhus coriaria L. (Rhus) commonly known as Somagh on body weight.

Detailed Description
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Rhus coriaria L.(Rhus) is a well-known spice widely consumed in the world which has also been utilized extensively for medicinal purposes. The antioxidant components of this plant made it a favorable target for laboratory and animal studies in different conditions such as oxidative stress cytotoxicity, diabetes and hyperlipidemia. Rhus (Somagh) is found in temperate and tropical regions worldwide, often growing in areas of marginal agricultural capacity. Rhus is used as an herbal remedy in traditional medicine because of its assumed analgesic, antidiarrheic, antiseptic, anorexic and antihyperglycemic properties. The fruits of Rhus contain flavonols, phenolic acids, hydrolysable tannins, anthocyans and organic acids such as malice, citric and tartaric acids. Some studies have shown that polyphenols could have beneficial effects on cardiovascular disease and cancer and could be regarded as bioactive compounds with a high potential health-promoting capacity. Phenolic compounds inhibit lipid peroxidation, scavenge the superoxide anion and hydroxyl radical, and enhance the activities of detoxifying enzymes. The aim of this study is to evaluate the effects of Rhus coriaria L. (Rhus) commonly known as Somagh on body weight.

Official Title
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The Effects of Rhus Coriaria L. (Rhus or Somagh) on Body Weight

Conditions
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Body Weight

Intervention / Treatment
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* Drug: Rhus Coriaria L.(Rhus)
* Drug: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Body mass index (BMI) >= 25 kg/m2 Exclusion Criteria: Diabetes mellitus Hypo. or hyperthyroidism Any systemic illnesses e.g. liver cirrhosis, acute or chronic renal failure, heart failure Use of drugs: Weight lowering agents, glucocorticoids, Oral contraceptive pills. Pregnancy History of allergic reaction to Somagh

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Rhus<br>500 mg twice daily after meal for 6 weeks | Drug: Rhus Coriaria L.(Rhus)<br>* 500 mg twice daily after meals for 6 weeks<br>* Other names: Somagh;|
| Placebo Comparator: Placebo<br>500 mg twice daily after meal for 6 weeks | Drug: Placebo<br>* 500 mg twice daily after meals for 6 weeks<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body Mass Index |  | 6 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Waist Circumference (cm) |  | 6 weeks | 
| Hip Circumference (cm) |  | 6 weeks | 
| Leptin (ng/ml) |  | 6 weeks | 
| Insulin (mU/l) |  | 6 weeks | 
| Fasting Blood Glucose (mg/dl) |  | 6 weeks | 
| Number of patients with adverse event |  | 6 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Body weight changes, Medicine, Traditional, Herbal medicine, Rhus, Waist Circumference, Waist-Hip Ratio, Body mass index