A Study to Assess the Effect of Concomitant Administration of Fluconazole on the Clinical Pharmacokinetics of Methadone

Study Overview
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Brief Summary
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To evaluate the pharmacokinetics and safety of concomitant administration of methadone and fluconazole. Injection drug users constitute the second largest subset of the U.S. population at risk for HIV infection and AIDS-associated mortality. Narcotic addiction is often treated by use of methadone. Fluconazole has been shown to be highly effective in treating symptomatic mucosal candidiasis, but it is unknown whether fluconazole affects methadone metabolism, which could result in symptoms of methadone withdrawal or overdose in patients taking the drugs in combination.

Detailed Description
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Injection drug users constitute the second largest subset of the U.S. population at risk for HIV infection and AIDS-associated mortality. Narcotic addiction is often treated by use of methadone. Fluconazole has been shown to be highly effective in treating symptomatic mucosal candidiasis, but it is unknown whether fluconazole affects methadone metabolism, which could result in symptoms of methadone withdrawal or overdose in patients taking the drugs in combination. Patients are randomized to receive methadone plus either fluconazole or placebo in clinic daily for 16 days. Study drugs are administered as close to 8 AM as possible. Patients must visit the Fort Greene clinic on study days 1, 2, 15, and 16; they may receive treatment at their home clinics on days 3 through 14.

Official Title
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A Study to Assess the Effect of Concomitant Administration of Fluconazole on the Clinical Pharmacokinetics of Methadone

Conditions
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Candidiasis, HIV Infections

Intervention / Treatment
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* Drug: Methadone hydrochloride
* Drug: Fluconazole


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria Concurrent Medication: Allowed: Antiretroviral therapy. Intermittent acetaminophen, aspirin, and ibuprofen. Patients must have: CD4 count >= 250 cells/mm3 within 3 months prior to study entry. Received a stable dose of methadone for a minimum of 30 days prior to study entry. Negative urine toxicology screen (except for methadone or methadone metabolites) within 14 days prior to study entry. Reasonably good health. Life expectancy of at least 6 months. Ability and willingness to comply with protocol requirements. NOTE: Patients will be recruited from the methadone maintenance treatment program currently administered by Addiction Research and Treatment Corporation. Enrollment of women is encouraged. NOTE: Patients who are currently enrolled in CPCRA treatment and prophylaxis trials are eligible for this study provided they have been permanently removed from study drug on the other protocol. Prior Medication: Required: Stable dose of methadone for a minimum of 30 days prior to study entry. Allowed: Prior antiretroviral therapy (dose should be stable for 14 days prior to study entry). Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions are excluded: Known sensitivity to azoles, methadone, and other opiate narcotics. Concurrent Medication: Excluded: Amiodarone. Anesthetics, general. Barbiturates. Carbamazepine. Cimetidine. Ciprofloxacin. Dexamethasone. Disulfiram. Erythromycin. Fluoroquinolones. Fluoxetine. Gestodene. Hydrochlorothiazide. Hypoglycemics, oral. Isoniazid. Itraconazole. Ketoconazole. Levomepromazine. MAO inhibitors. Methoxsalen. Nafcillin. Narcotic analgesics. Naringenin. Norethindrone. Omeprazole. Pentazocine. Phenothiazines. Phenytoin. Quinidine. Ranitidine. Rifabutin. Rifampin. Sedative hypnotics. Sulfaphenazole. Tranquilizers. Tricyclic antidepressants. Troleandomycin. Warfarin. Prior Medication: Excluded within 30 days prior to study entry: Ketoconazole, fluconazole, or itraconazole. Experimental drugs. Alcohol or illicit drug abuse.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Parallel Assignment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Methadone hydrochloride|nan|
|Drug: Fluconazole|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Methadone, Drug Interactions, Drug Therapy, Combination, Fluconazole, Antifungal Agents, Acquired Immunodeficiency Syndrome, AIDS-Related Complex