Effects of Regional Nerve Block on Cancer Recurrence

Study Overview
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Brief Summary
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It has been reported local anesthetics could inhibit tumor cell proliferation, metastasis and invasion ability，but it is still lack of clinical evidence. Our study aims to explore the effects of regional nerve block on cancer recurrence and the mechanism.

Detailed Description
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To study the effects of TAP block under ultrasound guide on the recurrence of gastric carcinoma, colon cancer, rectal carcinoma and liver cancer and the underlying mechanisms. To clarify the effects of Lateral thoracic nerve block under ultrasound guide on the recurrence of lung cancer and the underlying mechanisms.

Official Title
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Effects of Regional Nerve Block on Cancer Recurrence

Conditions
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Cancer Patient

Intervention / Treatment
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* Other: Normal saline
* Other: peripheral Nerve block


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with primary cancer undergoing elective surgery under general anesthesia Exclusion Criteria: Disagree to participate，drop out,lose track, infectious abdominal wall，abnormal puncture point，coagulation dysfunction，allergy of local anesthetic ，immune disease,cancer metastasis,mental disease, acute and chronic infectious disease or other severe disease.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: the patients in treatment group will received reginoal nerve block with 0.35% Ropivacane and 0.5% lidocaine in normal saline under ultrasound guide, while those in control group received equal volume of normal saline.
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Normal saline<br>equal volume of normal saline as treatment group | Other: Normal saline<br>* Injection of Normal saline around peripheral nerve<br>|
| Active Comparator: peripheral Nerve block<br>0.35% ropivacaine and 0.5% lidocaine in normal saline | Other: peripheral Nerve block<br>* Injection of local anesthetics around peripheral nerve<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the effect of nerve block on the cancer recurrence rate and survival rate postoperation | to trace cancer recurrence after tumor resection with CT scaning and tumor biological maker test for 5 years | up to 5 years after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| dosage of intraoperative anesthetic | Record the propofol and remifentanil during the operation | intraoperative period | 
| the effect of nerve block on the percentage and classification of immunocyte and content of cytokines | percentage and classification of immunocyte will be detected by Use flow cytometry, and cytokines will be detected by ELISA | at 0h, 24h, 48h after nerve block | 
| VAS after operation | Assess the visual analogue scale 24，48h after nerve block | at 24h, 48h after nerve block | 
| activity after operation | Observe recovery time of gastrointestinal function and off-bed activity after nerve block | up to 2 weeks | 
| Hospital stay | Observe length of hospital stay | up to 4 weeks after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Regional nerve block, cancer recurrence