Normal Values for Esophageal High Resolution Manometry in an Advanced Protocol Including Liquid Swallows and a Solid Test Meal

Study Overview
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Brief Summary
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Normal values for measurements of high resolution manometry in a protocol which includes isolated liquid swallows in upright and recumbent position, free drinking of water, a solid test meal and a postprandial observational period will be determined.

Detailed Description
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The investigators will recruit healthy volunteers and ask for study participation. After providing informed consent, participants will be questioned using standardized questionnaires assessing symptoms of reflux, dysphagia, gastrointestinal symptom burden and depression. Participants will be tested using our advanced protocol for high resolution esophageal manometry. This protocol includes individual liquid swallows, free drinking of water, a standardized test meal (200g rice) and a postprandial observational period. Normal values for liquid and solid swallows will be determined.

Official Title
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Normal Values for Esophageal High Resolution Manometry in an Advanced Protocol Using a Test Meal

Conditions
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Healthy

Intervention / Treatment
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* Other: Rice meal


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy volunteers without gastrointestinal co-morbidity Exclusion Criteria: Inability or unwillingness to provide informed consent Any relevant current or past gastrointestinal morbidity (including diseases relevant previous surgery). Relevant gastrointestinal symptoms Relevant medication (as specified below) within the last 4 weeks Age below 18 years

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: rice meal<br>High resolution manometry will be performed. Esophageal function will be tested using liquid swallows, solid swallows and a test meal (200g rice) | Other: Rice meal<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Values for HRM data (IRP, DCI, DL) in healthy volunteers | Normal values for measurements of high resolution manometry in a protocol which includes isolated liquid swallows in upright and recumbent position, free drinking of water, a solid test meal | 1 hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| discomfort on a VAS from 1-10 for each type of measurement | Discomfort during different steps of the investigation | 1 hour | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dysphagia, reflux symptoms, retrosternal pain