A Danish Nationwide Longitudinal Study on Prevalence of Periodontitis and Its Co-morbidities

Study Overview
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Brief Summary
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The project (PlanPerioMed) is a register-based study evaluating the associations and patterns of health care delivery between periodontitis and medical diseases using data from the Danish dental record system Dentalsuite (Plandent A/S) and national Danish health care registries with three overall hypotheses/ aims: Determine the extent to which periodontitis in registry data is associated with more odontological treatment services and treatment frequency. Determine if patients with systemic diseases attend dentists more frequently and receive more treatment services per patient than the population without these diseases. Determine to which extent periodontitis and received periodontal treatment affects the risk of medical diseases. The study will focus on association and trajectories of periodontitis and its treatment with three medical diseases, namely, Type 2 Diabetes Mellitus (Type 2 DM), Cardiovascular Diseases (CVD) and Rheumatoid Arthritis (RA). The dataset consists of approximately 4,000,000 people aged between 18 and 99 years attending private practice in Denmark. The results from PlanPerioMed study are likely to have ramifications for treatment guidelines for other periodontitis comorbidities, e.g. CVD and DM, and will thereby improve the quality of life for a wide range of patients and reduce long-term societal health care expenses related to periodontitis and its comorbidities.

Official Title
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A Danish Nationwide Longitudinal Registered Based Study on Prevalence, Treatment Patterns and Disease Trajectories of Periodontitis and Co-morbidities 'PlanPerioMed'

Conditions
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Periodontitis, Diabetes Mellitus, Type 2, Cardiovascular Diseases, Rheumatoid Arthritis

Intervention / Treatment
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* Procedure: Periodontal treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects with clinical registrations of DMFT, periodontal status and corresponding treatment codes Self-reported systemic diseases including Diabetes Mellitus Type 2, Cardiovascular Diseases and Rheumatoid Arthritis Subjects with Clinical Attachment Loss>=3mm, Probing Depth >= 3mm and bleeding on probing (as defined by World Workshop 2017- criteria for periodontitis) in clinical examination will be included in the study population. Exclusion Criteria: Subjects with more than 32 teeth Subjects with no clinical registrations

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Periodontal treatment|It includes surgical and non-surgical procedures depending on patient as well as tooth level.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Treatment frequency and type of treatment services | Number of treatment and odontological treatment services due to periodontitis | 25 years | 
| Treatment frequency and type of treatment services among patients with medical diseases | Number of treatment and odontological treatment services among patients with medical diseases due to periodontitis | 25 years | 
| Effect on medical diseases | Risk of medical diseases based on periodontal disease extent and received periodontal treatment | 25 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Periodontal Diseases, Periodontal Index, Periodontal Bone Loss, Periodontal Attachment Loss, Probing Depth, Bleeding on Probing, Clinical Attachment Loss, Diabetes Mellitus 2, DM type 2, Non-insulin dependent diabetes mellitus, Uncontrolled diabetes mellitus type 2, Increased blood glucose level, CVD, Cardiovascular risk, Heart disease, Heart disease risk factors, Smoking status, Socio-economic status, Register based, Longitudinal study, Danish nationwide study, systemic diseases