Effectiveness of Lavage With Alcohol - Chlorhexidine for Chemical Matricectomy

Study Overview
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Brief Summary
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To compare the efficacy of the lavage with 70% alcohol plus 0.5% chlorhexidine versus 70% alcohol in the surgical treatment of ingrown toenails.

Detailed Description
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The purpose of this study is to compare the efficacy of the lavage with 70% alcohol plus 0.5% chlorhexidine versus 70% alcohol during the phenolization procedure in the surgical treatment of ingrown toenails in patients undergoing for chemical matricectomy.

Official Title
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Effectiveness of the Lavage With 70% Alcohol Plus 0.5% Chlorhexidine Compared to 70% Alcohol for Chemical Matricectomy in the Surgical Treatment of Ingrown Toenails

Conditions
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Ingrown Toenail

Intervention / Treatment
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* Drug: 70% alcohol
* Drug: 70% alcohol - 0.5% clorhexidine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Older than 18 with onychocryptosis Exclusion Criteria: infection, history of tinea pedis, onychomycosis, paronychia, nail trauma or subungual hematoma, nail deformities and disorders, peripheral vascular disease or diabetes, cardiac disease, history of rheumatic fever, recent antibiotic use or current antimicrobial therapy, history of steroid use and recent nail polish use

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: alcohol - clorhexidine<br>Ingrown toenail irrigated using 70% alcohol - 0.5% clorhexidine | Drug: 70% alcohol - 0.5% clorhexidine<br>* In the intervention group five rounds of 3 ml wash of 70% alcohol - 0.5% clorhexidine was used to irrigate the exposed area of the nail to neutralize any residual effect of phenol and found out how much residual phenol is still in the wound.<br>* Other names: chlorhexidine-gluconate;|
| Active Comparator: 70% alcohol<br>Ingrown toenail irrigated using 70% alcohol | Drug: 70% alcohol<br>* After phenolization of the ingrown toenail the wound is irrigated with 15 cc solution of 70% alcohol plus 0.5% clorhexidine<br>* Other names: Ethanol;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quantity of phenol recovered in each lavage with each solution | The amounts of phenol in the samples were quantified by a Jasco modular high performance liquid chromatograph HPLC (Jasco International Co Ltd, Japan) equipped with a LG-2080-04 quaternary low-gradient unit, a PU-2080 pump, a DG-2080-54 degasser, an AS-2050-plus autosampler and a UV-2070 plus UV/Vis detector was used. A C18 column Luna (particle size 3 µm, 150 x 4.6 mm) (Phenomenex, Torrance, CA, USA) was selected for the chromatographic separation of the components, adjusting the column temperature to 30 °C (LC Ni-II/ADC oven). | up to 2 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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phenol, ingrown toenail, chemical matricectomy