The Role of Cognitive Function and Electroencephalography on Acute and Chronic Pain After Surgery

Study Overview
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Brief Summary
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The project will apply the methods of clinical observation experiment, (1) to collect the cognitive function data preoperatively and early postoperatively, as well as the pain score data at multiple time points pre- and postoperatively, and to observe the role of the degree of recovery of early postoperative cognitive function on acute pain and chronic pain after surgery. (2) to collect the resting-state electroencephalography (EEG) preoperatively, and to assess the role of EEG index system on the prediction of the degree of recovery of early postoperative cognitive function as well as the acute pain and chronic pain after surgery.

Detailed Description
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Patients after surgery are liable to suffer from moderate to severe acute pain and refractory chronic pain, which would lead to serious somatic and psychological suffering. Its successful treatment is a great challenge for pain physicians. To date, the mechanism of pain chronification after surgery remains unclear. Further, it is still lack of efficient preventive and therapeutic measures for this chronic pain. The project will apply the methods of clinical observation and animal experiment, (1) to collect the cognitive function data preoperatively and early postoperatively, as well as the pain score data at multiple time points pre- and postoperatively, and to observe the role of the degree of recovery of early postoperative cognitive function on acute pain and chronic pain after thoracic surgery. (2) to collect the resting-state electroencephalography (EEG) preoperatively, and to assess the role of EEG index system on the prediction of the degree of recovery of early postoperative cognitive function as well as the acute pain and chronic pain after thoracic surgery. The project will be able to determine the relationships between the degree of recovery of early postoperative cognitive function, as well as preoperative resting-state EEG indices and postoperative acute pain and chronic pain, and clarify the neural mechanism of acute pain and chronic pain after surgery. The expected outcomes of this study can contribute to early identification of the patients who are liable to develop into acute pain and chronic pain after surgery, and give them reasonable intervention in time, and provide effective solutions for the acute pain and chronic pain after surgery.

Official Title
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The Role of Cognitive Function and Electroencephalography on Acute and Chronic Pain After Surgery

Conditions
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Acute Pain, Chronic Pain, Thoracic Surgery, Electroencephalography, Brain Mechanism

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: surgery were planned to be performed under general anesthesia Educational attainment beyond high school Require postoperative analgesia and sign the informed consent Exclusion Criteria: with mental illness or a family history of mental illness Patients with cerebrovascular diseases or cerebrovascular accidents Previous head trauma history or craniotomy Using central analgesics, opioids addiction With a history of alcoholism do not understand the numerical rating scale(NRS) score and can not use patient-controlled analgesia(PCA）

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| acute pain | numerical rating scale(NRS)>3 | the third day of the surgery | 
| chronic pain | numerical rating scale(NRS)>3 | the second month of the surgery |