Impact of Pharmaceutical Interviews Regarding the Management of Adverse Effects Related to the Antibiotic Therapy Used to Treat Osteoarticular Infections During Return Home

Study Overview
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Brief Summary
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The primary objective is to evaluate the impact of Pharmaceutical Interviews in the patient self-management of non-severe side effects caused by antibiotics prescribed for the treatment of osteoarticular infections when the patient returns home.

Official Title
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Impact of Pharmaceutical Interviews Regarding the Management of Adverse Effects Related to the Antibiotic Therapy Used to Treat Osteoarticular Infections During Return Home

Conditions
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Bone and Joint Infection

Intervention / Treatment
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* Other: pharmaceutical interview


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient > or =18 years; Informed consent signed; French-speaking and reading; Affiliated to a social insurance; Benefiting from medical and surgical care for an osteoarticular infection; Treated with an oral antibiotic therapy on discharge from hospital. Indication of the antibiotic therapy osteoarticular infection; Return home immediately after discharge. Exclusion Criteria: Refusal to participate Protected adult patient, under guardianship or curatorship. Minor patient Patient benefiting from an AME. Pregnant or breastfeeding woman. Non-French speaking patient. Patient unable to understand the course of the study. Patient with a documented history of cognitive or psychiatric disorders. Patient treated with oral antibiotic therapy for an indication other than osteoarticular infection. Patient treated with parenteral antibiotic therapy. Discharge: Institution (EHPAD), rehabilitation or other health establishment. Patient systematically using one of the symptomatic treatments proposed in the discharge prescription before hospitalization.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patients with pharmaceutical interview<br>Pharmaceutical interview with pharmacist: to be informed treatment taken and related SAE informations at the end of hospitalization. | Other: pharmaceutical interview<br>* Pharmaceutical interview with pharmacist: to be informed treatment taken and related SAE informations at the end of hospitalization<br>|
| No Intervention: Patients without pharmaceutical interview<br>Control group without interview | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adverse effects self-management measurement | Phone call to evaluate the self-management of adverse effects. Self-management evaluation (optimal choice/non-optimal choice) performs thanks to the use of a standardized decision-tree. Proportion of patients with an optimal or non-optimal self-management. | at day 7 | 
| Adverse effects self-management measurement | Phone call to evaluate the self-management of adverse effects. Self-management evaluation (optimal choice/non-optimal choice) performs thanks to the use of a standardized decision-tree. Proportion of patients with an optimal or non-optimal self-management. | at day 14 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient knowledge assessment | Questionnaire, 12 points: proportion of patients reaching a score upper than 10 proportion of patients reaching a score between 6 and 9 proportion of patients reaching a score lower than 6 | at day 7 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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osteo articular infection, adverse event, antibiotic treatment, pharmaceutical interview