Study of PTG-300 in Non-Transfusion Dependent and Transfusion-Dependent Beta-Thalassemia Subjects With Chronic Anemia

Study Overview
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Brief Summary
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This is a Phase 2 open-label, single-arm design study with dose escalation by subject cohort . The study is designed to monitor the PTG-300 safety profile, to obtain preliminary evidence of efficacy of PTG-300 for the treatment in β-thalassemia.

Detailed Description
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This is a Phase 2 open-label, single-arm design study with dose escalation by subject cohort and with the potential for individual titration (dose increase or decrease) within each cohort. The study is designed to monitor the PTG-300 safety profile, to obtain preliminary evidence of efficacy of PTG-300 for the treatment of chronic anemia in β-thalassemia and to evaluate the appropriate dosing regimen for PTG-300 in the target population

Official Title
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A Phase 2 Study of PTG-300 in Non-Transfusion Dependent (NTD) and Transfusion-Dependent (TD) β-Thalassemia Subjects With Chronic Anemia

Conditions
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β-thalassemia, Ineffective Erythropoiesis, Chronic Anemia

Intervention / Treatment
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* Drug: PTG-300


Participation Criteria
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Eligibility Criteria
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Main Inclusion Criteria: Male and female subjects aged 18 to 65 years, inclusive (Cohorts 1-4b). Male and female subjects aged 12-<18 years, with a minimum weight of 30 kg (Cohorts 5 and 6). Documented diagnosis of β-thalassemia with no other Hgb abnormality. Inclusion criteria applicable only for NTD β-thalassemia subjects: Mean Hgb < 10.0 g/dL of two measurements (one performed 7-28 days prior to dosing and the other performed within 7 days prior to dosing). Requirement of < 6 units RBC transfusion in a 24 week period with the last transfusion at least 8 weeks before screening. Inclusion criteria applicable only for TD β-thalassemia subjects: Transfusion requirement of at least 6 units of RBC in the 24 weeks prior to screening with no transfusion free period > 45 days. Last RBC transfusion 5-10 days prior to dosing. Main Exclusion Criteria: Subjects with Sickle Cell disease, Hgb H, Hb Bart's hydrops foetalis or hemoglobin S Infection requiring hospitalization or IV antimicrobial therapy, or opportunistic infection within 6 months of dosing, any infection requiring antimicrobial therapy within 2 weeks of dosing; history of infection with human immunodeficiency virus (HIV). Subject has a concurrent clinically significant, unstable or uncontrolled cardiovascular, pulmonary, hepatic, renal, gastrointestinal, genitourinary, hematological, coagulation, immunological, endocrine/metabolic or other medical disorder that, in the opinion of the Investigator, might confound the results of the study or pose additional risk to the subject by their participation in the study. Known primary or secondary immunodeficiency. History within 6 months of screening of any of the following: myocardial infarction, unstable angina, transient ischemic attack, decompensated heart failure requiring hospitalization, congestive heart failure (New York Heart Association Class 3 or 4), uncontrolled arrhythmias, cardiac revascularization, stroke, uncontrolled hypertension (resting systolic blood pressure [BP] > 160mmHg or resting diastolic BP > 100mmHg on more than one occasion) or uncontrolled diabetes (Hgb A1c > 9% or > one episode of severe hypoglycemia). Pregnant or lactating females.

Ages Eligible for Study
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Minimum Age: 12 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Sequential Assignment
Interventional Model Description: Multiple PTG-300 dose levels/regimens are planned to be tested for each subpopulation of β thalassemia (NTD and TD) on separate arms: Cohort 1: 3 mg subcutaneous (SC) weekly Cohort 2: 10 mg SC weekly Cohort 3: 20 mg SC weekly Cohort 4a: 40 mg SC weekly Cohort 4b: 40 mg SC every 2 weeks Cohort 7: 80 mg SC weekly Cohort 8: 40 mg SC twice a week Additional Cohorts (Cohorts 5,6,9,10, and 11) will include subjects between 12 years of age and less than 18 years of age.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: PTG-300 Active<br>Drug: PTG-300 Subcutaneous | Drug: PTG-300<br>* Subcutaneous (SC)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| NTD: Proportion of responders at each dose | NTD subjects who achieve an increase in Hgb without transfusion | 4 week period | 
| TD: Proportion of clinical responders at each dose | TD subjects who achieve a reduction in red blood cell (RBC) units required over an 8 week period | 8 week period | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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chronic anemia, β-thalassemia