Incidence of Reflux Esophagitis After Pancreaticoduodenectomy

Study Overview
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Brief Summary
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Reflux esophagitis is a common complication following distal gastrectomy. According to the investigators preliminary data, an Roux-en--Y gastrointestinal reconstruction in pancreaticoduodenectomy is associated with higher rates of reflux esophagitis. In this study, the investigators will investigate the incidence of reflux esophagitis after above procedure by the 24-h pH monitoring of esophagogastric junction.

Detailed Description
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Reflux esophagitis is a common complication following distal gastrectomy. Recently, an Roux-en--Y gastrointestinal reconstruction has been used increasingly to prevent reflux esophagitis; however, reflux esophagitis after pancreaticoduodenectomy (also including distal gastrectomy) has never been studied. In our preliminary retrospective study of 371 patients having PD (158 standard PD and 213 pylorus-preserving PD) at our hospital, after a median follow-up of 20 months (range, 2-110 months), 40 patients (10.8%) developed reflux esophagitis - 15 (9.5%) in the standard PD group, and 25 (11.7%) in the PPPD group. Multivariate logistic regression analysis revealed the only significant factors related to reflux esophagitis is Roux-en-Y gastrointestinal reconstruction independent of preservation of the pylorus. To our surprise, there is no significant difference in occurrence of GERD between patients after standard PD (15 of 158 patient) and PPPD (25 of 313 patients, P=0.49). We postulate reflux esophagitis following a PPPD in patients without past history of GERD is most likely caused by disruption of reflux-preventing systems at the gastroesophageal junction, thereby allowing reflux of gastric acid into esophagus. If the postulation is true, GERD after PPPD should be acidic in nature. To test this hypothesis we propose a prospective randomized study to compare preoperative and postoperative parameters, including esophageal morphology, bile acid concentration, trypsin activity of esophageal refluxate, COX2 mRNA expression of lower esophageal mucosa, and 24 hour pH monitor of lower esophagus. Moreover, to test the effect of a Roux-en-Y reconstruction to prevent GERD after PD, studied patients will be randomized into Roux-en-Y and control groups to study inter-group differences in incidence of GERD and marginal ulcer after PD. Acidic GERD should be treated with proton pump inhibitor. In contrast, alkaline GERD should be treated with pro-kinetic agent such as primperan and mopride. With this study, we can learn more about the nature of post-PD GERD following various gastrointestinal reconstructions and can give patient more personalized therapy.

Official Title
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Effect of a Roux-en-Y Reconstruction on Reflux Esophagitis After Pancreaticoduodenectomy

Conditions
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Reflux Esophagitis

Intervention / Treatment
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* Procedure: Methods of gastrojejunostomy reconstruction


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age greater than 18 years and planned PD for a lesion of either the pancreatic head or the periampullary region Exclusion Criteria: history of abdominal or pelvic radiation hepatic dysfunction (Child-Pugh > 2) renal dysfunction (serum creatinine concentration > 3 mg/L, hemodialysis, or both) cardiac dysfunction (New York Heart Association functional class > III, stroke history) pregnancy history of intestinal anastomosis of the large bowel without a diverting stoma

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Surgery, Roux-en-Y , reflux esophagitis<br>Patients with roux-en-Y reconstruction (study group) | Procedure: Methods of gastrojejunostomy reconstruction<br>* Roux-en-Y reconstruction in pancreaticoduodenectomy<br>* Other names: Roux-en-Y anastomosis versus gastrojejunostomy only;|
| surgery, traditional gastrojejunostomy<br>Traditional gastrojejunostomy reconstruction (control group). | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence and severity of reflux esophagitis | Use panendiscopy to assess the reflux esopagitis | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidenc of marginal ulcer | Use endoscopy to assess the marginal ulcer | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pancreaticoduodenectomy, Roux-en-Y reconstruction, Reflux esophagitis