TEAS to Reduce Propofol Consumption During General Anesthesia

Study Overview
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Brief Summary
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The study is aimed at whether transcutaneous electrical acupoint stimulation (TEAS) during general anesthesia could reduce the need for propofol in patients undergoing minor surgery.

Official Title
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Effect of Transcutaneous Electrical Acupoint Stimulation on Propofol Consumption During General Anesthesia

Conditions
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Anesthesia

Intervention / Treatment
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* Other: acupoint stimulation
* Other: non-acupoint stimulation
* Other: electrodes attached


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients undergoing minor surgeries including laparoscopic surgery and breast surgery under general anesthesia Patients with written informed consent Exclusion Criteria: Patients with difficulty to communicate,including psychiatric disorder and Alzheimer's disease Patients with drug abuse Patients with disease of central nervous system Patients with renal or hepatic dysfunction

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Transcutaneous acupoint stimulation<br>Electrical stimulation was given through electrodes attached to skin at Ximen and Shenmen acupoint during anesthesia | Other: acupoint stimulation<br>* stimulation was given at acupoints<br>Other: electrodes attached<br>* electrode were attached to skin<br>|
| Placebo Comparator: Non-acupoint stimulation<br>Electrical stimulation was given through electrodes attached to skin at shoulder (non-acupoint) during anesthesia | Other: non-acupoint stimulation<br>* stimulation was given at non-acupoints<br>Other: electrodes attached<br>* electrode were attached to skin<br>|
| Sham Comparator: Control<br>patients were with electrodes attached but no stimulation was given | Other: electrodes attached<br>* electrode were attached to skin<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| propofol consumption |  | from induction to the end of surgery,at an average of 1 hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| time to awake |  | from end of propofol infusion to open eyes to verbal command,at an average of 30 minutes | 
| time to extubation |  | from end of propofol infusion to open eyes to verbal command,at an average of 30 minutes | 
| effect site concentration of propofol at awake |  | from end of propofol infusion to open eyes to verbal command,at an average of 30 minutes | 
| highest sedation score during stay at postanesthesia care unit |  | from end of surgery to discharge from post anesthesia care unit, at an average of 1 hour | 
| nausea and vomiting during stay at postanesthesia care unit |  | 30min after surgery |