linjc16/ctgov huggingface dataset:
Feasibility of Combined Genomics/Transcriptomics for Patients With Lymphoma

Study Overview
=================
Brief Summary
-----------------
To learn more about the usefulness of molecular testing with the Molecular Functional (MF) Portrait (a commercial test conducted by the sponsor of this study, BostonGene) in guiding lymphoma care.

Detailed Description
-----------------
Primary Objective: • To determine the feasibility and turnaround of clinical WES and transcriptome sequencing Secondary Objectives: To determine the frequency of actionable DNA and RNA alterations To determine the concordance of DNA and RNA alterations To determine the frequency of molecularly matched therapy To determine the feasibility of identifying mechanism(s) of acquired resistance with genomic profiling To determine the feasibility of molecularly matched therapy to acquired resistance alterations Exploratory Objectives: To determine the feasibility of prioritizing targets with precision analytics To determine clinical outcomes in patients receiving molecularly matched therapy To determine the role of additional emerging diagnostic technologies

Official Title
-----------------
Feasibility of Combined Genomics/Transcriptomics for Patients With Lymphoma

Conditions
-----------------
Lymphoma

Intervention / Treatment
-----------------
* Other: Molecular Functional Portrait


Participation Criteria
=================
Eligibility Criteria
-----------------
Patient Eligibility: Inclusion Criteria: Male/female patients who are at least 18 years of age on the day of informed consent signing. Patients must have a histologically documented diffuse large B-cell lymphoma requiring therapy. Provision of written informed consent for the study. Exclusion Criteria: 1. None

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Molecular Testing<br>Molecular Functional (MF) Portrait (a commercial test conducted by the sponsor of this study, BostonGene) in guiding lymphoma care. | Other: Molecular Functional Portrait<br>* Participants will be asked to allow previously-collected tumor tissue to be used for the MF Portrait test<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of participants who have genomic test results available in <=7 days |  | through study completion an average of 1 year |
Thousand Asian American Study

Study Overview
=================
Brief Summary
-----------------
The Thousand Asian American Study or TAAS aims to test 2,000 foreign-born and children of foreign born Asian Americans residing in Sacramento county residents for HBV and (2) counsel at least 90% of those whose screening results are positive for HBV.

Detailed Description
-----------------
The Thousand Asian American Study or TAAS aims to better understand the factors associated with testing for hepatitis B viral (HBV) testing among foreign-born Asian and African adult residents of Sacramento county, characteristics of those infected with HBV, and the efficacy of follow-up and linkage to care for those infected with HBV, and develop a research platform for future studies. Thus, what the investigators want to do is 1) test 2000 foreign-born Sacramento county residents for HBV and (2) counsel at least 90% of those whose screening results are positive for HBV. The investigators want to better characterize factors associated with HBV testing and factors that may differentiate those determined to be free of infection, infected with HBV, and those with resulting primary liver cancer.

Official Title
-----------------
Thousand Asian American Study (TAAS)

Conditions
-----------------
Hepatitis B

Intervention / Treatment
-----------------
* Other: Hepatitis B


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All foreign-born Asians and any foreign-born adults born in CDC-defined high to intermediate endemic areas residing in Sacramento County, California. Exclusion Criteria: Individuals who have been previously serologically tested for Hepatitis B (self-reported).

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Asian Americans<br>Foreign born or children of foreign born Asian American from Hepatitis B endemic areas residing in Sacramento, CA. | Other: Hepatitis B<br>* Hepatitis B Surface Antigen, Hepatitis B Surface Antibody and Hepatitis B Core AB, Total Testing<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients or adult children of patients born in Hepatitis B endemic countries (rate of 2% or higher) getting screened for hepatitis B. |  | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients that are hepatitis B positive that receive counseling regarding their infection. |  | 1 year |
Confounding Factors in Ocular Surface Microbiome Research

Study Overview
=================
Brief Summary
-----------------
To elucidate confounding factors in ocular surface microbiome research and to confirm the presence of a core ocular surface microbiome and its temporal stability.

Detailed Description
-----------------
The investigator will take a conjunctival sample of both eyes of a group of volunteers together with an extensive questionnaire. Furthermore, 50 volunteers will be sampled repeatedly during one year or two years.

Official Title
-----------------
Confounding Factors in Ocular Surface Microbiome Research

Conditions
-----------------
Ocular Surface Microbiome

Intervention / Treatment
-----------------
* Diagnostic Test: Conjunctival swab


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The subject is fluent in written and verbal Dutch The subject is capable of giving informed consent Exclusion Criteria: Use of glaucoma drops Use of antibiotic drops < 1 month before sampling

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Interventional Model Description: A conjunctival swab will be taken from healthy volunteers
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: conjunctival swab<br>A conjunctival swab of both eyes will be taken | Diagnostic Test: Conjunctival swab<br>* A conjunctival swab of both eyes will be taken at the same time together with an extensive questionnaire.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Richness and evenness of distribution of the microbial flora measured as operational taxonomic units on a single moment | A conjunctival swab and extensive questionnaire will be taken to search for a core ocular surface microbiome and confounding factors | 20 minutes for samples and filling the questionnaires | 
| Change in richness and evenness of distribution of the microbial flora, measured as operational taxonomic units, over time | A conjunctival swab will be taken on different points in time to investigate the temporal stability of the conjunctival microbial flora | 20 minutes for the first sample and questionnaire, 5 minutes for all other visits | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Ocular surface microbiome, Temporal stability, Confounding factors
A Prospective Evaluation of Open-Angle Glaucoma Subjects on Two Topical Hypotensive Medications Treated With One Suprachoroidal Stent

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to assess the efficacy and safety of one iStent supra stent in the reduction of intraocular pressure associated with primary open-angle glaucoma.

Detailed Description
-----------------
The study assesses the efficacy and safety of one iStent supra stent in the reduction of intraocular pressure associated with primary open-angle glaucoma.

Official Title
-----------------
A Prospective Evaluation of Open-angle Glaucoma Subjects on Two Topical Hypotensive Medication Treated With One Suprachoroidal Stent

Conditions
-----------------
Subject With Primary Open-angle Glaucoma (POAG)

Intervention / Treatment
-----------------
* Device: iStent Supra Stent


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosed with primary open-angle glaucoma (POAG) Subjects on two topical hypotensive medications Exclusion Criteria: Traumatic, uveitic, neovascular, or angle closure glaucoma Fellow eye already enrolled

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: One iStent Supra Stent and medication<br>The study assesses the efficacy and safety of one iStent Supra stent in the reduction of intraocular pressure associated with primary open-angle glaucoma | Device: iStent Supra Stent<br>* Implantation of one iStent Supra Stent through a small temporal clear corneal incision<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean diurnal Intraocular Pressure reduction of greater than or equal to 20% at month 12 vs. baseline |  | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean diurnal Intraocular Pressure < 18 mmHg at month 12 |  | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Ocular Hypertension, Open angle, Glaucoma, Surgery, Eye Diseases
A Comparative Study of KHK6188

Study Overview
=================
Brief Summary
-----------------
This is a placebo-controlled, double blind, crossover study to evaluate the efficacy and safety of KHK6188 in postherpetic neuralgia when administered orally for 2 weeks.

Official Title
-----------------
Phase II Study of KHK6188 (A Placebo-controlled, Double Blind, Crossover Study of KHK6188 in Postherpetic Neuralgia)

Conditions
-----------------
Postherpetic Neuralgia

Intervention / Treatment
-----------------
* Drug: KHK6188
* Drug: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with pain for ≥ 3 months and ≤ 1 year following onset of a herpes zoster rash Patients with a mean pain intensity score (11-point numerical rating scale) of ≥ 4 Patients whose rash has been healed Patients who are able to fill their patient diary Patients who provided written voluntary informed consent to participate in the study Exclusion Criteria: Patients who have other pain or disease which may impair the self assessment of pain Patients who have dementia, depression or schizophrenia which may affect the self assessment of pain History or presence of severe cardiovascular disease, hepatic dysfunction, renal failure, respiratory disease, blood disease or CNS disorder History or presence of a drug allergy Patients who have a history of a diagnosis of cancer or a treatment of cancer within 5 years prior to the study entry Patients received an investigational medication within 4 months (6 months for biologic medication such as antibody) prior to the informed consent Women of child bearing potential who do not agree to avoid pregnancy from the time of providing the consent until 3 months after the end of dosing, or men of reproductive potential who do not agree to avoid pregnancy from the time of the first dose until 3 months after the end of dosing Patients who are pregnant, lactating, or possibly pregnant Patients judged to be inappropriate to enter the study by a investigator or a subinvestigator

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: KHK6188, high dose<br> | Drug: KHK6188<br> <br> |
| Experimental: KHK6188, low dose<br> | Drug: KHK6188<br> <br> |
| Placebo Comparator: Placebo<br> | Drug: Placebo<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of pain intensity score |  | baseline and 2weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of allodynia severity |  | baseline and 2 weeks | 
| Change of global impression |  | baseline and 2 weeks |
Clinical Comparison of RPDs Retained by Conical and Galvanoformed Double Crowns.

Study Overview
=================
Brief Summary
-----------------
The aim of this prospective clinical trial was to investigate the clinical performance and complication rate of RPDs (Removable partial dentures) retained on conventional conical double crowns in comparison to galvanoformed telscopic double crowns. Additionally the OHIP (Oral Health related Qualitiy of Life)and the abrasion of the teeth were investigated.

Conditions
-----------------
Denture, Partial, Removable, Dental Prosthesis Retention, Oral Health, Tooth Abrasion

Intervention / Treatment
-----------------
* Procedure: survival failure of more than 20 %


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Indication for RPDs retained by double crowns; 2 to 6 Abutment teeth; Exclusion Criteria: limited contractual capability and absence of consent of the patient

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: survival failure of more than 20 %|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
The Role of Nitric Oxide Synthase in Circulating Progenitor Cell Function

Study Overview
=================
Brief Summary
-----------------
Our main hypothesis is that EPC function is impaired in some populations with high cardiovascular risk as a result of reduced eNOS-dependent NO production.

Detailed Description
-----------------
To determine if a correlation exists between EPC function and eNOS-dependent NO production in EPCs from populations with high versus low cardiovascular risk: High and low cardiovascular risk subjects will be identified based on age or history of cardiovascular disease. Endothelial function will be measured by ultrasound. EPCs will be isolated from peripheral blood of these subjects. EPC function will be assessed by measuring adhesion to endothelium, migration, proliferation, and differentiation, and compared to their expression and activity of eNOS.

Official Title
-----------------
The Role of Nitric Oxide Synthase in Circulating Progenitor Cell Function

Conditions
-----------------
Cardiovascular Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Willing and able to give written informed consent and comply with study requirements Adult of 18 years or older Subjects willing to provide blood and tissue samples Exclusion Criteria: Failure to give informed consent. Those unable to consent for themselves. Those who cannot read English. Patients on Viagra, Levitra, or Cialis Patients with malignant disease Patients with hematological abnormalities Patients with fevers of unknown origin Severe comorbidity or alcohol/drug dependence Women who are post-menopausal and on hormone replacement therapy, or premenopausal and on birth control pills (premenopausal women will be screened verbally and then by assay of LH and FSH levels in blood samples to identify women in the follicular phase of their menstrual cycle, to reduce variability)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>High cardiovascular risk age over 61 years. | |
| 2<br>Low Cardiovascular risk age over 61. | |
| 3<br>High cardiovascular risk age over 25 but under 61. | |
| 4<br>Low cardiovascular risk age over 25 under 61. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cardiovascular, vasodilation, endothelium, Subjects with high cardiovascular risk
Endo-Band: Endoscopic Band Ligation for Weight Loss

Study Overview
=================
Brief Summary
-----------------
To the best of our knowledge, this is the first study to use endoscopic band ligation for weight loss. All ligatures will be performed in the gastric body starting at the distal body; 5 parallel rows, with the last one in the proximal body.The entire procedure can be completed in 30 min. Oxygen is used for endoscopic air insufflation.Endoscopy is performed using propofol for sedation.

Detailed Description
-----------------
The idea of band ligation of the gastric body is to induce multiple gastric ulcers that forms a fibrotic scars which can lead to marginal narrowing of the lumen; same as that occurred in the esophagus following band ligation of esophageal varices or in the antrum following band ligation of GAVE.

Official Title
-----------------
Endoscopic Band Ligation for Weight Loss

Conditions
-----------------
Obesity

Intervention / Treatment
-----------------
* Device: Endoscopic Band Ligation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: BMI > 27 Exclusion Criteria: Any contraindication for endoscopy Any gastric bleeding lesions Uncontrolled use of anticoagulants or NSAID's

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Band Ligation<br>Band ligation of gastric body for weight loss | Device: Endoscopic Band Ligation<br>* Band ligation of the gastric body for weight loss<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Weight Loss | BMI Change | 3 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Obesity, BMI
Benefit of Surgical Hardware Removal Following Clavicle Fracture

Study Overview
=================
Brief Summary
-----------------
Little is known about the beneficial aspects of elective implant removal following plate osteosynthesis of displaced clavicle fractures.

Detailed Description
-----------------
Elective implant removal accounts for up to 30% of all orthopaedic surgeries. While there is general acceptance about the need of implant removal for obvious reasons, such as infections or implant failure, little is known about the beneficial aspects in cases of minor reasons. Therefore, we initiated this study to define patients' benefit of elective implant removal following plate osteosynthesis of displaced clavicle fractures. Patients and Methods Prospective evaluation of patients was conducted before implant removal and 6 weeks postoperative. Subjective and objective criteria included patients' satisfaction, pain rating on a visual analog scale (VAS) and active range of motion (ROM) pre- and 6 weeks postoperative. Functional scoring included the SPADI, DASH score, the Constant Score and the Munich Shoulder Questionnaire (MSQ).

Official Title
-----------------
Do Patients Benefit From Elective Implant Removal Following Plate Osteosynthesis of Clavicle Fractures - a Prospective Trial

Conditions
-----------------
Clavicle Fracture

Intervention / Treatment
-----------------
* Procedure: Hardware Removal


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age >18 years Radiologically consolidated clavicle fracture following ORIF using a superior anatomically preformed locking plate asking for elective implant removal written informed consent. Exclusion Criteria: Pregnancy Under-aged Delinquent patients.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group Removal<br>All patient receiving surgical removal of plate osteosynthesis | Procedure: Hardware Removal<br>* elective removal of plate osteosynthesis at the clavicle<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Shoulder function | Munich Shoulder Questionnaire allowing for calculation of Constant Score (0-100), Dash (0-100) | 6 Week post surgery |