NEAT - Prevention and Treatment of Overweight and Obesity.

Study Overview
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Brief Summary
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This study will investigate the effect on Non-exercise Activity Thermogenesis (NEAT) when implementing active workstation at offices compared to conventional office work. The primary hypothesis is that this implementation will lead to a significant increase in time spent walking per day.

Detailed Description
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NEAT consists of the energy expenditure of the physical activities that are non sporting-like and that we perform in our everyday life, such as walking, cleaning, shoveling snow etc. Which occupation we have play a big role in how much we are able to active our NEAT during our days and those who have more active jobs can expend up to 1500kcal more per day than those with sedentary jobs. This study aims to try and increase NEAT at offices where sedentary time often is high. Participants will be randomized to either an intervention group or to a control group. Participants in the control group will continue to work at their regular desk, but will receive an individual health talk in the beginning of the study where diet and physical activity recommendations will be discussed.Participants in the intervention group will receive the same individual health talk and a treadmill desk, which they will use for 12 months at self-selected speed. They will be recommended to walk on the treadmill for at least 1 hour per day.

Official Title
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Non-exercise Activity Thermogenesis (NEAT) - Prevention and Treatment of Overweight and Obesity

Conditions
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Overweight, Obesity

Intervention / Treatment
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* Behavioral: Treadmill workstation
* Behavioral: Health talk


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Office workers with mainly sedentary tasks BMI 25-40 Exclusion Criteria: Severe depression and/or anxiety Exhaustion disorder Diabetes Mellitus Severe cardiovascular disease Severe kidney disease Musculoskeletal disorders that prohibit walking on a treadmill Contraindications for physical activity Thyroidea illness Pregnancy For fMRI-study, additional exclusion criteria are: Implanted metal- or electrical devices Pregnancy Extraneous metal pieces in the body

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 67 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Treadmill workstation<br>Will receive a health talk with recommendations about diet and physical activity habits and will also receive a treadmill workstation at regular office site for 12 months. | Behavioral: Treadmill workstation<br>* The intervention group will receive a treadmill workstation for 12 months. They will use this at self-selected speed and will be recommended to use this for at least 1 hour per day. Participants in the control group will continue with conventional office work at their regular desk. Participants in the intervention group will receive four boosting e-mails during the study period, in which they will be encouraged to use the treadmill.<br>Behavioral: Health talk<br>* Participants in both groups will receive a health talk with recommendations about diet and physical activity habits.<br>|
| Experimental: Control group<br>Will receive a health talk with recommendations about diet and physical activity habits. Will continue to work with conventional office work at their regular desk. | Behavioral: Health talk<br>* Participants in both groups will receive a health talk with recommendations about diet and physical activity habits.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in physical activity and sedentariness at 12 months | Measured with an accelerometer (ActiGraph) and an inclinometer (ActivPAL). | Baseline, 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in metabolism at 12 months | Metabolism: 2h glucose tolerance test. lipids, Hb1Ac | Baseline, 12 months | 
| Change from baseline in anthropometrics at 12 months | Length, height, weight, waist circumference, hip circumference, sagittal height, pulse, blood pressure. | Baseline, 12 months | 
| Change from baseline in body composition at 12 months | Measured with Dual X-Ray Absorptiometry (DXA) | Baseline, 12 months | 
| Change from baseline in musculoskeletal pain at 12 months | Measured with the Chronic Pain Grade Questionnaire | Baseline, 12 months | 
| Change from baseline in stress at 12 months | Measured by assessing cortisol levels in the saliva at 4 time points during one day. Also measured with the stress- and energy scale. | Baseline, 12 months | 
| Change from baseline in depression/anxiety at 12 months | Measured with the Hospital Anxiety and Depression Scale. | Baseline, 12 months | 
| Change from baseline in Quality of Life at 12 months | Measured with 2 questions from the SF-36. | Baseline, 12 months | 
| Change from baseline in cognitive Function and functional brain response at 12 months | Measured with a cognitive test battery and functional MRI (fMRI). Levels of Brain-Derived Neurotrophic Factor (BDNF) is measured in the plasma. | Baseline, 12 months | 
| Qualitative interview study | Participants will be interviewed about experiences from being part of the study and about attitudes and factors that influences them to be physically active. | 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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NEAT, Treadmill desk