Postprandial Efficacy of Probiotic Fruit Beverages on Glucose Tolerance and Insulin Resistance

Study Overview
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Brief Summary
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Consumption of polyphenol-rich fruits and vegetables may improve the postprandial glucose and insulin responses and hence promote well-being. It has previously been observed that consumption of a bilberry drink decreases the postprandial insulin demand. In the present study, the impact of probiotic fruit beverages with different polyphenol profiles on the postprandial levels of glucose and insulin, were investigated.

Official Title
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Early Postprandial Efficacy of Probiotic Fruit Beverages on Glucose Tolerance and Insulin Resistance in Healthy Adults

Conditions
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Postprandial Hyperglycemia

Intervention / Treatment
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* Other: Bilberry
* Other: Blackcurrant
* Other: Mango
* Other: Beetroot
* Other: Rose hip
* Other: Glucose drink


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy, not on medication, non-allergic, individuals aged 18-65 years old, having a BMI between 20-30 kg/m2 and also maintaining stable body weight, i.e. less than 5% weight change in the last three months before the study. Exclusion Criteria: -

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Bilberry<br>A bilberry-based beverage with fermented oatmeal | Other: Bilberry<br>* Fruit beverage with bilberry and fermented oatmeal<br>|
| Experimental: Blackcurrant<br>A blackcurrant-based beverage with fermented oatmeal | Other: Blackcurrant<br>* Fruit beverage with blackcurrant and fermented oatmeal<br>|
| Experimental: Mango<br>A mango-based based beverage with fermented oatmeal | Other: Mango<br>* Fruit beverage with mango and fermented oatmeal<br>|
| Experimental: Beetroot<br>A beetroot-based based beverage with fermented oatmeal | Other: Beetroot<br>* Fruit beverage with beetroot and fermented oatmeal<br>|
| Experimental: Rose hip<br>A rose hip-based based beverage with fermented oatmeal | Other: Rose hip<br>* Fruit beverage with rose hip and fermented oatmeal<br>|
| Active Comparator: Glucose drink<br>A reference glucose drink | Other: Glucose drink<br>* A reference glucose drink<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Efficacy of the study products on the postprandial serum insulin | The postprandial incremental area under the curve for serum insulin | Incremental area under the curve for serum insulin from 0 min up to 120 min following the ingestion of the study product | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Efficacy of the study products on the postprandial serum glucose | The postprandial incremental area under the curve for serum glucose | Incremental area under the curve for serum glucose from 0 min up to 120 min following the ingestion of the study product |