Differences in Frail and Non-frail Critically-ill Patients in Functional Outcomes

Study Overview
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Brief Summary
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This is a prospective analysis of patient registry data of intensive care patients. The aim is to investigate if frailty is a predictor of decline of functional status of critically ill patients during their hospital stay.

Detailed Description
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Elderly critical-ill patients with a high frailty level are becoming increasingly important in the ICU and the health system. Especially, questions about the course of the individual proceeding, withhold of therapy and level of care are controversial among caretakers, as outcome and functional independence remain still unclear in these patients. This applies particularly in view of the fact that large studies such as VIP1 showed an inverse association of high frailty classes with short-term survival. Our main objective in this study was to focus on functional outcome and independency measured by Barthel Index after ICU stay regarding frailty, the effect of critical care and severity and prognosis of the disease.

Official Title
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Differences in Frail and Non-frail Critically-ill Patients in Functional Outcomes

Conditions
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Physical and Rehabilitation Medicine, Rehabilitation, Frailty, Critical Care, Outcome Assessment, Critical Illness, Exercise Therapy, Intensive Care Unit

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: intensive care stay > 48 hours Exclusion Criteria: none

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Critically ill patients<br>Critically ill patients admitted to intensive care for more than 48 hours | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Probability not to deteriorate in functional status during the hospital stay | Analysis of the course of functional status measured by the Barthel Score sub-components transfer and ambulation during the hospital stay. The Scale ranges from 0 (no transfer) to 15 (transfer to chair and back) for transfer and from 0 (no ambulation) to 15 (coming into stand and walk 50m without supervision) for ambulation. | a median of 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Functional status before hospital admission to ICU discharge | Analysis of the change of functional status measured by the Barthel Score sub-components transfer and ambulation from before hospital admission to ICU discharge. The Scale ranges from 0 (no transfer) to 15 (transfer to chair and back) for transfer and from 0 (no ambulation) to 15 (coming into stand and walk 50m without supervision) for ambulation. | a median of 20 days | 
| Change in Functional status before hospital admission to hospital discharge | Analysis of the change of functional status measured by the Barthel Score sub-components transfer and ambulation from before hospital admission to hospital discharge. The Scale ranges from 0 (no transfer) to 15 (transfer to chair and back) for transfer and from 0 (no ambulation) to 15 (coming into stand and walk 50m without supervision) for ambulation. | a median of 30 days | 
| ICU length of stay | Duration of stay on intensive care | a median of 11 days | 
| Hospital length of stay | Duration of stay in the hospital | a median of 30 days | 
| Rate of discharge disposition to home | Rate of participants being discharged home after the hospital stay. | 1 day | 
| ICU mortality | Expired during the intensive care stay | a median of 11 days | 
| Hospital mortality | Expired during the hospital stay | a median of 22 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Functional Outcome, Patient Outcome, Intensive Care, Critical Care Outcomes, Early Mobilization, Early Rehabilitation, Functional Status