Breastfeeding and Gut Health

Study Overview
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Brief Summary
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The aim of the study is to evaluate the impact of early nutrition on gut health in children. A prospective cohort of newborns will be recruited at birth and followed up to 4 years of age. Information on parent's nutritional habits and life style, breastfeeding duration and child's complementary feeding, will be collected. Cord blood cells and stools will be collected at birth, 6 months, 2 years and 4 years of age for implementing a biological collection. Gut health will be evaluated in children during the first four years of life based on fecal secretory immunoglobulin A (SIgA) and presence of digestive symptoms. Precise data on breastfeeding practices and their short- and medium-term effects on the health of the child, in particular and in an innovative way on gut health, will be obtained.

Official Title
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Influence of Breastfeeding on Gut Health in Children

Conditions
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Gut Health

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: For the mother: Pregnant woman (>18 years old) followed at the Lille University Jeanne de Flandres Maternity Woman who can speak, read and write in French Single pregnancy Informed consent Living in the Lille area For the father: Men >18 years old Informed consent Exclusion Criteria: For the mother: Impossibility to participate to the study follow-up Woman under guardianship or curatorship Woman involved in another study inconsistent with biological samples collection For the child after birth: Prematurity <37 weeks Impossibility to participate to the study follow-up Child under judicial protection measure Child involved in another study inconsistent with biological samples collection

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between exclusive breastfeeding and gut health based on the non-invasive measurement of fecal secretory immunoglobulin A (sIgA) |  | AT 4 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between gut health and the duration of exclusive breastfeeding | defined by the production of Igas in the faeces and the duration of exclusive breastfeeding (1 month, 1-2 months, 2-4 months, 4-6 months, 6 months) collected by mother's interrogation. | A 1 month, 1-2 months, 2-4 months, 4-6 months, 6 months | 
| Correlation between the mother's feeding habits during pregnancy and the child's gut health during the first 4 years of life | Nutritional data collected via the Food Frequency Questionnaire (FFQ) and the mother's obstetric record and Intestinal health of the child during the first 4 years of life evaluated by the production of Igas | At 6 months, 2 years and 4 years | 
| Correlation between sIgA and child growth and gastro-intestinal disorders | defined by Production of Igas in children and the head circumference, weight and height of the child reported in the health log and the presence of gastrointestinal symptoms evaluated according to the criteria of ROME IV. | At 6 months, 2 years and 4 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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breastfeeding, early nutrition, intestinal microbiota