Evaluation of Left Ventricular Function by Speckle Tracking Echocardiography in Patient Hospitalised in Intensive Care Unit for Vaso-occlusive Crisis

Study Overview
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Brief Summary
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Vaso-occlusive crisis in Sickle cell disease might alter myocardial function through micro vascular obstruction. Evaluation of strain alteration using speckle tracking echocardiography is a non invasive technique that may allow us to observe such myocardial dysfunction. No such study has yet been conducted in patient hospitalised in intensive care unit. Our hypothesis is that strain alteration during vaso-occlusive crisis, if they do exist, can be correlated with other markers of myocardial injury such as troponin level or thoracic pain.

Official Title
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Evaluation of Left Ventricular Function by Speckle Tracking Echocardiography in Patient Hospitalised in Intensive Care Unit for Vaso-occlusive Crisis

Conditions
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Sickle Cell Disease

Intervention / Treatment
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* Other: Evaluation of global longitudinal strain using routinely recorded echocardiography images


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Hospitalisation in an intensive care unit for vaso-occlusive crisis Exclusion Criteria: Pregnancy Individuals under guardianship Unsufficient echogenicity Thoracic pain prohibiting echocardiography assessment

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients hospitalised in ICU for vaso-occlusive crisis<br> | Other: Evaluation of global longitudinal strain using routinely recorded echocardiography images<br>* There are no particular intervention performed in patients in this study, because echocardiography is part of the standard of care of patients hospitalised in the ICU for vaso occlusive crisis.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Global longitudinal strain | Measure of global longitudinal strain using speckle tracking echocardiography | Day 0 | 
| Global longitudinal strain | Measure of global longitudinal strain using speckle tracking echocardiography | Day 1 | 
| Global longitudinal strain | Measure of global longitudinal strain using speckle tracking echocardiography | Day 2 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Troponine level |  | Day 0 | 
| Troponine level |  | Day 1 | 
| Troponine level |  | Day 2 | 
| Electrocardiogram QT interval |  | Day 0 | 
| Electrocardiogram QT interval |  | Day 2 | 
| Electrocardiogram ST elevation |  | Day 0 | 
| Electrocardiogram ST elevation |  | Day 2 | 
| Electrocardiogram negative T waves |  | Day 0 | 
| Electrocardiogram negative T waves |  | Day 2 | 
| Thoracic pain | Numerical rating scale from 0 to 10 assessed by the patient | Day 0 | 
| Thoracic pain | Numerical rating scale from 0 to 10 assessed by the patient | Day 1 | 
| Thoracic pain | Numerical rating scale from 0 to 10 assessed by the patient | Day 2 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ICU Intensive Care Units, Transthoracic Echocardiography, Left Ventricular Function