Clinical Transcriptomics in Systemic Vasculitis (CUTIS)

Study Overview
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Brief Summary
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Multi-center observational study to evaluate the histopathology and transcriptome of cutaneous lesions in patients with several different types of vasculitis.

Detailed Description
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This study employs a multi-center approach to evaluate cutaneous vasculitis across several forms of idiopathic vasculitis. Patients with cutaneous manifestations of vasculitis will be evaluated by teams of primary vasculitis care providers and Dermatologists in order to facilitate optimal selection of patients and sampling of lesions. A punch skin biopsy at a site of active vasculitis will be the source of material for histopathologic and transcriptomic evaluation. The histopathology of cutaneous vasculitis will be characterized using a standardized approach.

Official Title
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Clinical Transcriptomics in Systemic Vasculitis (CUTIS)

Conditions
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Cryoglobulinemic Vasculitis (CV), Drug-induced Vasculitis, Eosinophilic Granulomatosis With Polyangiitis (EGPA), IgA Vasculitis, Isolated Cutaneous Vasculitis, Granulomatosis With Polyangiitis (GPA), Microscopic Polyangiitis (MPA), Polyarteritis Nodosa (PAN), Urticarial Vasculitis, Vasculitis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Have a cutaneous lesion (purpuric macules, palpable purpura, retiform purpura, nodules, ulcers, or urticarial) believed to be related to active vasculitis Have a suspected or confirmed diagnosis of: Cryoglobulinemic vasculitis (CV) Drug-induced vasculitis Eosinophilic granulomatosis with polyangiitis (EGPA) IgA vasculitis Isolated cutaneous vasculitis Granulomatosis with polyangiitis (GPA) Microscopic polyangiitis (MPA) Polyarteritis nodosa (PAN) Urticarial vasculitis Be willing and able to provide written informed consent (or assent for those under Exclusion Criteria: You are less than five years old Considered not to be a candidate for a biopsy or have a higher risk of developing an infection, bleeding, etc., from the biopsy, or a doctor believes that the risks for you participating in this study do not outweigh the potential benefit of learning information from your biopsy You have a neutrophil count (type of white blood cell) less than 1500/mm3, platelet count less than 50,000/mm3, or a hemoglobin less than 7 g/dL You have an uncontrolled disease that could prevent you from completing the study procedures You have an active infection at or near the potential biopsy site, have poor circulation, or have bony prominence or other structure that would increase your risk of complications if you participated in this study You are pregnant or nursing You are not able to provide informed consent

Ages Eligible for Study
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Minimum Age: 5 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of clinical data and linked biopsy specimens | Describe cutaneous vasculitis across several different forms of systemic vasculitis using histopathology. | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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DIV, CSS, EGPA, HSP, GPA, MPA, PAN, Wegeners