Neuropsychological Assessment Of The Oldest-Old Population.(NEUROPSIC-GR)

Study Overview
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Brief Summary
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Neuropsychological tests currently considered to evaluate the cognitive performance of the oldest-old population (more than 80 years) are not adapted to this group population. This trial aims to determine the normal limits for this group population of a set of 18 neuropsychological test. Results may improve the diagnostic cognitive evaluation of this population.

Detailed Description
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120 subjects more than 80y old (non-institutionalized) grouped in 4 age categories (80-84, 85-89, 90-94, 95 or more) will be evaluated through 18 neuropsychological tests (usually considered at Memory Clinics). Subjects will be recruited from 5 Primary Care Centers by a random selection method (stratified by age group). Normal limits will be defined by the percentiles of test punctuations. Previously, punctuations will be adjusted by age and education level by lineal regression.

Official Title
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Neuropsychological Assessment Of The Non-institutionalized Oldest-Old Population. Multicenter Normative Study.

Conditions
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Dementia, Cognition Disorders in Old Age

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 80 or more years old Residence at Comarca del Garraf Able to be traslated to study center Sufficient reading and writing capacity to carry out the neuropsychological tests, at the evaluator's discretion. Exclusion Criteria: Patient at end-of-life situation or with a very short life expectancy (days-weeks). Hospital admission in the previous 3 months. History of relevant mental illness: major depression, psychosis, bipolar disorder, obsessive-compulsive disorder. Disease of the central nervous system with possible cognitive impairment: Parkinson's disease, multiple sclerosis, brain tumor, stroke with cognitive impairment, epilepsy, severe traumatic brain injury. History of alcoholism or substance abuse. Severe sensory deficit that prevents performing neuropsychological tests, at the discretion of the evaluator. Positive SS-IQCODE questionnaire or Lobo's Cognitive Mini-examination Test (spanish adaptation of Minimental of Folsteint test) with a score < 23 (20 in people with low schooling or illiteracy). Dementia criteria according to the Diagnostic and Statistical Manual of Mental Disorders IV.

Ages Eligible for Study
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Minimum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognitive Performance | Cognitive performance will be evaluated by 18 neuropsychological test (quantitative scores) which cover all main cognitive domains (memory and learning, language, perceptual-motor abilities, executive functions and attention). | This outcome will be evaluated at Memory Clinic Unit, following the enrollment visit. The evaluation of this outcome will last approximately 60 minutes. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Geriatric Assessment, Aged, 80 and over, Dementia, Cognition Disorders in Old Age