Strength Training on Pancreatic Cancer

Study Overview
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Brief Summary
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The purpose of this study is to determine whether prednisone, methotrexate, and cyclophosphamide are effective in the treatment of rapidly progressive hearing loss in both ears due to autoimmune inner ear disease (AIED).

Detailed Description
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Sudden out-of-hospital cardiac arrest (OOH-CA) remains a significant cause of death, in spite of recent declines in overall mortality from cardiovascular disease. Existing methods of emergency resuscitation are inadequate due to time delays inherent in the transport of a trained responder with defibrillation capabilities to the side of the OOH-CA victim. Existing Emergency Medical Services (EMS) systems typically combine paramedic Emergency Medical Technician (EMT) services with some level of community involvement, such as bystander cardiopulmonary resuscitation (CPR) training. Some communities include automated external defibrillators (AEDs) at isolated sites or in mobile police or fire vehicles. A comprehensive, integrated community approach to treatment with AEDs would have community units served by these volunteer non-medical responders who can quickly identify and treat a patient with OOH-CA. Such an approach is termed Public Access Defibrillation (PAD).

Official Title
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Strength Training on Pancreatic Cancer

Conditions
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Pancreatic Neoplasms, Cachexia, Myopathy

Intervention / Treatment
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* Behavioral: strength training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with pancreatic carcinomas after surgery (resection or exploration) given consent Exclusion Criteria: acute infection pain no mobility or ability for walking or standing severe neurological disorders (apoplex, morbus Parkinson, paresis of the lower extremeties) severe cardiac or cardiovascular diseases (z.B. heart insufficiency NYHA III, myocardial infarction <3 months) rhytmical disorders, that contraindicate ergospirometric examinations cardiac therapy with digitalis pharmacy unclear syncopes severe pulmonal insufficiency renal insufficiency (GFR < 30% at Krea >3 mg/dl) synchronous participation in an other clinical trial
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>pancreatic cancer patients | Behavioral: strength training<br>* strength training, high intensity, twice up to 3 times per week<br>* Other names: cachexia;|
| Experimental: 2<br>pancreatic cancer patients | Behavioral: strength training<br>* strength training, high intensity, twice up to 3 times per week<br>* Other names: cachexia;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| muscle mass and strength |  | after 8 weeks of intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| quality of life |  | after 8 weeks of intervention |