Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 2

Study Overview
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Brief Summary
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This study will test the hypothesis that constitutionally poorer Eustachian tube function predisposes to middle-ear pathology during a viral upper respiratory infection.

Detailed Description
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The most well supported immediate cause of Otitis media (OM) is a pre-existing or concurrent viral upper respiratory tract infection (vURI). However, not all vURI episodes cause OM and a variety of predisposing factors has been suggested to explain this selectivity. Based on our preliminary work using a model of experimental viral infections in adults, we hypothesize that the constitutional efficiency of the Eustachian tube (ET) to supply the middle ear (ME) with gas and thereby stabilize ME pressure at near ambient is a primary risk factor for OM during vURI. Here, we test the hypothesis that constitutionally poorer ET function (F) predisposes to ME pathology during a vURI. Specifically, we will use ETF testing protocols relevant to the pressure-chamber to evaluate constitutional ETF in ≈ 160 susceptible, adult volunteers who will be exposed to rhinovirus as part of our funded study entitled Social and Psychological Risks for Infectious Disease (PI: S. Cohen, PI: CHP subcontract: WJ Doyle) and document the ETF and ME responses to infection over a 5-day post-exposure, cloister period. Also, using protocols relevant to the pressure-chamber, we will evaluate constitutional ETF in 80 children who will be enrolled into our funded study entitled Role of Virus and Genetic Susceptibility in Otitis Media (PI: CM Alper) and followed for vURI and OM from October through April. From both data sets, we will extract measures of ETF efficiency and determine using logistic regression with appropriate control variables (e.g. demographic data etc) if a single or combination of ETF variables predicts an abnormal ME response in rhinovirus infected adults or OM during a rhinovirus cold in children.

Official Title
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Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 2

Conditions
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Upper Respiratory Infection

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participating/participated in one of the two identified studies Exclusion Criteria: No longer meet inclusion/exclusion criteria of parent studies

Ages Eligible for Study
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Minimum Age: 2 Years
Maximum Age: 54 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>adults who participate in study, Social and Psychological Risks for Infectious Disease here at Children's Hospital of Pittsburgh | |
| 2<br>children 2-6 years who participate in Role of Virus and Genetic Susceptibility study here at Children's Hospital of Pittsburgh | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Eustachian tube function |  | 3 months (adults), 6 months (children) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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otitis, Eustachian tube, virus, Middle ear disease