Serum, Plasma, DNA and Tissue Bank in Chronic Obstructive Pulmonary Disease and Lung Cancer

Study Overview
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Brief Summary
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A biobank of Serum, plasma, DNA samples together with clinical information including specific questionnaires, complete pulmonary function and chest CT-scan, is prospectively collected in patients seen at the investigators' clinical service. The objective is to study candidate gene pathways in COPD and or lung cancer and to associate them with the clinical characteristics and phenotypes of COPD/emphysema and lung cancer. In subgroups of well characterised patients, other biological materials are also collected (lung tissue biopsies, peripheral blood mononuclear cells).

Detailed Description
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All patients with a smoking history of at least 15 pack years, an minimal age of 50 years and an recent available CT scan are enrolled. All subjects with a diagnosis of lung cancer are also collected (irrespective of age and smoking behavior). In addition the investigators collect: specific questionnaires (MRC, CCQ and smoking history) medical and professional history complete pulmonary function (spirometry, bodyplethysmography and diffusing capacity) serum, plasma and DNA samples. In specific subgroups the investigators also collect: Peripheral blood mononuclear cells Lung tissue - if available - from a surgical procedure (lung transplantation or lobectomy)

Official Title
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Serum, Plasma, DNA and Tissue Bank of Patients With Chronic Obstructive Pulmonary Disease, Lung Cancer and Smoking Controls.

Conditions
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Chronic Obstructive Pulmonary Disease, Lung Cancer

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria for smokers: A smoking history of at least 15 pack years and age of 50 years or older Complete pulmonary function on day of visit Chest CT-scan within one year of enrollment 4 weeks from exacerbation Exclusion Criteria for smokers: Less than 15 pack years Younger than 50 year Other pulmonary diseases interfering with CT or pulmonary function Asthma Inclusion Criteria for lung cancer patients: new diagnosis of proven lung cancer chest CT scan within 2 months of enrollment Complete pulmonary function Exclusion Criteria for lung cancer patients not able to perform pulmonary function Absence of histological diagnosis of lung cancer

Ages Eligible for Study
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Minimum Age: 25 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Smoking controls<br>Smokers without lung cancer and without COPD | |
| COPD patients<br>Smokers with COPD but without lung cancer | |
| Lung cancer patients<br>smokers - never smokers with lung cancer | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serological, cytological, histological and genetic analysis of biomarkers or genes which are involved in the pathogenesis of COPD/Emphysema/Lungcancer. | All cases are prospectively collected in University hospital Leuven, Belgium. Of enrolled subjects data are collected at 0,1,3 and 6 years interval | 0-1-3-6 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COPD, Lung cancer, genes, DNA