Safety Study of the Histone Deacetylase Inhibitor, CHR-3996, in Patients With Advanced Solid Tumours

Study Overview
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Brief Summary
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CHR-3996 is one of a new class of anti-cancer agents - histone deacetylase inhibitors (HDACi) - that has exhibited pleiotropic activity both in vitro and in vivo against a range of human cancer cells. Regulation of the acetylation of both histone and non-histone proteins by histone deacetylase enzymes is one of the key mechanisms involved in epigenetic control of gene expression. HDACi have demonstrated activity in both in vitro cytotoxicity, and in vivo tumour xenograft studies

Official Title
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A Phase I Study to Evaluate the Safety and Tolerability of the Histone Deacetylase Inhibitor, CHR-3996, in Patients With Advanced Solid Tumours

Conditions
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Solid Tumor

Intervention / Treatment
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* Drug: CHR-3996


Participation Criteria
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Eligibility Criteria
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INCLUSION CRITERIA: Signed, informed consent Histologically or cytologically confirmed malignant solid tumour refractory to standard therapy or for which no standard therapy exists Recovered from all acute adverse effects of prior therapies (excluding alopecia and grade 1 neuropathy) Adequate bone marrow, hepatic and renal function including the following Hb ≥ 9.0 g/dL, absolute neutrophil count ≥ 1.5 x 109/L, platelets ≥100 x 109/L Total bilirubin ≤ 1.5 x upper normal limit, excluding cases where elevated bilirubin can be attributed to Gilberts Syndrome AST (SGOT), ALT (SGPT) ≤ 2.5 x upper normal limit (or 5x UNL in the presence of liver metastases) Creatinine ≤ 1.5 x upper normal limit Age ≥ 18 years Performance status (PS) ≤ 2 (ECOG scale) Estimated life expectancy greater than 3 months Female patients with reproductive potential must have a negative serum pregnancy test within 7 days prior to start of trial. Both women and men must agree to use a medically acceptable method of contraception throughout the treatment period and for 3 months after discontinuation of treatment. Acceptable methods of contraception include IUD, oral contraceptive, subdermal implant and double barrier (condom with a contraceptive sponge) EXCLUSION CRITERIA: Anti-cancer therapy including chemotherapy, radiotherapy, endocrine therapy, immunotherapy or use of other investigational agents within the 4 weeks prior to trial entry (or a longer period depending on the defined characteristics of the agents used e.g. 6 weeks for mitomycin or nitrosourea, 3 months for antibodies). In patients with progressive disease, continuation of LHRH agonists for prostate cancer, bisphosphonates for bone disease and corticosteroids are permitted provided the dose does not change during the trial Patients with a prior allogeneic haematopoietic stem cell transplant Co-existing active infection or serious concurrent illness Patients with significant cardiovascular disease as defined by: history of congestive heart failure requiring therapy history of angina pectoris requiring treatment or myocardial infarction within 6 months prior to trial entry presence of severe valvular heart disease presence of an atrial or ventricular arrhythmia requiring treatment LVEF below the normal range at the study centre Uncontrolled hypertension A history of QTc abnormalities or with a mean QTc interval >450 msec at screening Any medical or other condition that in the investigator's opinion renders the patient unsuitable for this study due to unacceptable risk Psychiatric disorders or altered mental status precluding understanding of the informed consent process and/or completion of the necessary studies Gastrointestinal disorders that may interfere with absorption of the study drug. Patients with known brain tumours or metastases should be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events More than 6 prior chemotherapy regimens Patients requiring growth factor support (erythropoietin, G(M)CSF, etc) Patients requiring palliative radiotherapy within the last 4 weeks prior to study entry Uncontrolled hypercalcaemia (>CTCAE v3 grade I) Abnormal plasma potassium or magnesium levels (CTCAE v3 grade 3 or greater) despite therapy Pregnant or breast-feeding women

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Oral, once daily administration of CHR-3996 to determine safety and tolerability | Drug: CHR-3996<br>* Once daily oral ingestion of capsules (5, 10, 20 or 40 mg), dose depending on cohort, treatment cycle of 28 days<br>* Other names: HDACi;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To determine the safety, tolerability, dose-limiting toxicities (DLT), maximum acceptable dose (MAD) and maximum tolerated dose (MTD) of CHR-3996 when administered orally to patients with advanced or treatment refractory solid tumours |  | After 28 days treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To determine pharmacokinetic parameters of CHR-3996 |  | After 1 and 28 days treatment | 
| To perform a preliminary assessment of the anti-tumour activity of CHR-3996 |  | During treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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tumour, Solid tumour, histone deacetylase inhibitor, dose escalation, cancer