Ocular Discomfort Assessment After Intravitreal Injections

Study Overview
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Brief Summary
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In this study, ocular discomfort following intravitreal injection in naïve patients will be studied, as well as the efficacy of wetting agent (Optive eyewash) to prevent ocular discomfort.

Detailed Description
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In naive patients, the two first intravitreal injections will be studied. Within the first injection, no wetting agent will be delivered. Within 72hours after this first intravitreal injections, patients will be contacted by phone by a nurse to complete questionnaires on quality of life and on ocular pain and eye discomfort. After the second injection, a treatment with wetting agent will be prescribed. With 72hours after the second injection, quality of life, ocular discomfort as well as acceptability and tolerance of the eye drops will also be assessed by a phone questionnaire.

Official Title
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Evaluation de la gêne Oculaire après Injections intravitréennes

Conditions
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Macular Degeneration, Diabetic Retinopathy, Retinal Artery Occlusion, Myopia, Degenerative

Intervention / Treatment
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* Drug: Optive


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient over 18 years old Patient with social healthcare Patient understanding French language Patient requiring anti-VEGF treatment by intravitreal injection Exclusion Criteria: Patient treated by Ozurdex® before Patient with known and treated ocular dryness Non naive patient for intravitreal injection Hypersensitivity to Carmellose Patient who received wetting agent within the 3 last months History of povidone-iodine allergy Pregnant or breastfeeding mother

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Optive after the second anti-VEGF injection<br>Naive patients requiring intravitreal injection. Patients will be enrolled in this study within the 2 first intravitreal injections to assess quality of life and ocular discomfort without wetting agent (ie after the first injection) and with wetting agent (ie after the second injection) | Drug: Optive<br>* Optive eye drops will be prescribed to each included patients after their second intravitreal injection; patients will received 1 drop in the affected eye 2 times a day during 3 days<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of the overall scores of the ocular discomfort questionnaire after the 2 first intravitreal injection in naïve patients |  | within the 72h after the first and the second intravitreal injections | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Intravitreal injection, AMD, Diabetic Retinopathy, Retinal Artery Occlusion, Myopia, Degenerative, eye drops