NEAT! Technology to Increase Breaks in Sedentary Behavior in Adults With Diabetes

Study Overview
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Brief Summary
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Sedentary behavior is associated with an increased risk of mortality and many health conditions including type 2 diabetes, obesity, cardiovascular disease, and metabolic syndrome, independent of the time spent in moderate-to-vigorous intensity physical activity (MVPA). Furthermore, independent of total sedentary time and MVPA, Healy et al. observed that individuals who had more breaks in sedentary time had lower 2-h plasma glucose. Recent experimental findings also suggests that breaking up prolonged bouts of sedentary behavior (≥ 20 minutes) with either light or moderate intensity activity for 2 minutes reduces postprandial glucose and insulin responses.10 Replacing sedentary time with light-intensity activity or nonexercise activity thermogenesis (NEAT) may help to reduce the health consequences of sedentary behavior. The purpose of this study is to develop a smartphone application (NEAT!) to encourage sedentary adults with diabetes to increase breaks in prolonged bouts of sedentary behavior objectively measured by an accelerometer. NEAT! will be refined by modifying technology created for the ENGAGED trial (RC1DK087126) and will work in conjunction with a Bluetooth enabled accelerometer that can detect bouts of sedentary behavior. When a sedentary bout (≥ 20 minutes) is detected, the smartphone application will trigger a reminder prompt to the user encouraging him/her to participate in NEAT for at least 2 minutes. Following the development, testing, and refining of the application, a sample of 10 sedentary adults with type 2 diabetes will be recruited to participate in a one month trial to examine the feasibility and acceptability of NEAT!. To our knowledge, this is the first study to design and examine the acceptability of a smartphone application that will target interrupting sedentary behavior with NEAT using objectively measured sedentary time in a diabetic population.

Official Title
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NEAT! Technology to Increase Breaks in Sedentary Behavior in Adults With Diabetes

Conditions
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Diabetes Mellitus

Intervention / Treatment
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* Behavioral: NEAT!


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 21-70 years of age have physician diagnosed type 2 diabetes that is currently being treated by dietary modification, oral agents, or insulin currently and plan on having an Android smartphone for the next 2 months be willing to wear an accelerometer and use the NEAT! application spend the majority of the day sitting. Exclusion Criteria: unable to ambulate without assistance

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: NEAT!<br>Participants will use the NEAT! smartphone application and accelerometer over a 1 month period. | Behavioral: NEAT!<br>* Participants will wear the accelerometer and use the NEAT! application during waking hours for 1 month. The NEAT! app will prompt participants to stand up when they have been sitting for a prolonged period.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acceptability of NEAT! | How many participants would continue to use or use NEAT! in the future | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adherence to NEAT! | NEAT usage (days/month) | 1 Month | 
| Breaks in Sedentary Behavior | Changes in the number of breaks in sedentary behavior will be assessed via accelerometry between baseline and 1 month | Baseline and 1 month | 
| Changes in Total Sedentary Time | Changes in total sedentary behavior will be assessed via accelerometry between baseline and 1 month | Baseline and 1 month |