Efficacy of Tranexamic Acid In Reducing Blood Loss During Cesarean Section Because Of Placenta Previa

Study Overview
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Brief Summary
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This study evaluate role of tranexamic acid in reducing blood loss among pregnant women undergoing cesarean section because of placenta previa .Half of participants will receive tranexamia acid drug While the other half will receive placebo.

Detailed Description
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Tranexamic Acid used in the field of obstetrics to decrease blood loss during and after cesarean section . Tranexamic Acid is an antifibrinolytic agent which cause reversible and competitive blockade of the lysine binding sites in plasminogen molecules . It is a synthetic analog of amino acid lysine and its action is to reduce blood loss

Official Title
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Efficacy of Tranexamic Acid In Reducing Blood Loss Among Pregnant Women During Cesarean Section Because Of Placenta Previa

Conditions
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Postpartum Haemorrage Sever Bleeding After Delivery

Intervention / Treatment
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* Drug: Tranexamic Acid


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age 18 -38 Body mass index <30 , Diagnosis of placenta previa Exclusion Criteria: patient with bleeding disorder , hepatic and renal disease. contraindication to tranexamic acid as allergy , hypersensitivity to tranexamic acid and known thromboembolic event during pregnancy . other causes ofantepartum haemorrhage eg :accidental haemorrhage, rupture uterus. type 1,2 of placenta previa anterior type 3,4 of placenta previa posterior causes of overdistended uterus like :multiple pregnancy, polyhydraminos

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 38 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: tranexamic acid group<br>tranexamic acid given as 1 gram intravenous dose dilute in 500 cc of ringer lactate 20 minute before cesarean section | Drug: Tranexamic Acid<br>* tranexamic acid or placebo are given before cesarean section in patient with placenta previa<br>* Other names: cyclo kapron;|
| Placebo Comparator: placebo group<br>the control group will receive 500 cc of ringer lactate 20 minute before cesarean section | Drug: Tranexamic Acid<br>* tranexamic acid or placebo are given before cesarean section in patient with placenta previa<br>* Other names: cyclo kapron;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Amount of Actual blood loss in each group | observational | 6hour after operation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in haemoglobin before operation and 24 hours after operation | observational | 24 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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obstetric bleeding placenta previa