Pharmacokinetics, Immunogenicity, Safety and Tolerability of MEDI3506 in Health Chinese Participants

Study Overview
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Brief Summary
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This study is to evaluate the pharmacokinetics, immunogenicity, safety and tolerability of investigational drug MEDI3506 with single dose in Healthy Chinese participants.

Detailed Description
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A phase I, randomised, double-blind, placebo-controlled parallel-group study to evaluate the pharmacokinetics, immunogenicity, safety, and tolerability of single dose of MEDI3506 in healthy Chinese Participants

Official Title
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A Phase I, Randomized, Double-blind, Placebo-controlled, Dose-ascending Study to Evaluate the Pharmacokinetics, Immunogenicity, Safety, and Tolerability of MEDI3506 in Healthy Chinese Participants

Conditions
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Healthy Volunteer

Intervention / Treatment
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* Biological: MEDI3506
* Drug: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria Provision of signed and dated, written informed consent prior to any study specific procedures. Capable of giving signed informed consent as described in Appendix A which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol. Aged 18 to 45 years (inclusive, at the time of signing the ICF). Healthy, non smoking Chinese participants. Definition of non-smoker: non-smoker for at least the past 12 months with pack history ≤5 pack years. Able and willing to comply with the requirements of the protocol and complete the study until the end of the safety follow up period. Have a body mass index between 19 and 24 kg/m2 , inclusive. Male and female. Females of childbearing potential who are sexually active with a nonsterilized male partner must use a highly effective method of contraception from enrolment throughout the study until their final follow-up visit. Cessation of contraception after this point should be discussed with a responsible physician. Periodic abstinence (calendar, symptothermal, post-ovulation methods), withdrawal (coitus interruptus), spermicides only, and lactational amenorrhoea method are not acceptable methods of contraception. Female condom and male condom should not be used together. All women of child bearing potential must have a negative serum pregnancy test result at Visit 1. A highly effective method of contraception is defined as one that results in a low failure rate (i.e., less than 1% per year) when used consistently and correctly. Highly effective birth control methods include: a vasectomised partner, Implanon®, bilateral tubal occlusion, intrauterine device/levonorgestrel intrauterine system, Depo-Provera™ injections, oral contraceptive, and Evra Patch™, Xulane™, or NuvaRing®. Females not of childbearing potential who are either permanently sterilized (hysterectomy, bilateral oophorectomy, or bilateral salpingectomy), or who are postmenopausal. Women will be considered postmenopausal if they have been amenorrheic for 12 months or more following cessation of exogenous hormonal treatment prior to the planned date of randomization and follicle stimulating hormone (FSH) levels in the postmenopausal range. Nonsterilised males who are sexually active with a female partner of childbearing potential must use condom and spermicide from enrolment through the study period until their final follow up visit. Because male condom and spermicide is not a highly effective contraception method, female partners of a male study participants must also use a highly effective method of contraception as defined above throughout this period. Exclusion Criteria Any active medical or psychiatric condition or other reason which, in the opinion of the investigator, may compromise the safety of the participant in the study or interfere with evaluation of the investigational product or reduce the participant's ability to participate in the study. Any clinically relevant abnormal findings on physical examination of the cardiovascular system including ECG and vital signs at screening, and Day 1(pre-dose): a. Abnormal vital signs, after 10 minutes supine rest (confirmed by 1 controlled measurement), defined as any of the following: i. Fever greater than 37.5℃ ii. SBP < 90 mmHg or ≥ 140 mmHg iii. DBP < 50 mmHg or ≥ 90 mmHg iv. Pulse < 45 or > 100 bpm b. Any clinically significant abnormalities in rhythm, conduction or morphology of the resting ECG, and any clinically significant abnormalities in the 12-lead ECG, as considered by the investigator that may interfere with the interpretation of QTc interval changes, including abnormal ST-T wave morphology, or left ventricular hypertrophy. Any other clinically relevant abnormal findings on physical examination or laboratory testing including haematology, coagulation, clinical chemistry or urinalysis at screening or randomization, which in the opinion of the investigator may compromise the safety of the participant in the study or interfere with evaluation of the investigational product or reduce the participant's ability to participate in the study. Abnormal findings include, but are not limited to: Serum alanine transaminase' (ALT) or aspartate transaminase' (AST) > 2.0 × upper limit of normal (ULN) or total bilirubin (TBL) > 2 × ULN (unless due to Gilbert's disease) or evidence of chronic liver disease Total white blood cell count < 4,000 × 106/L Neutrophil count < 1,500/mm3 Platelet count < 100,000/mm3 Haemoglobin < 110 g/L History or a reason to believe that a participant has a history of drug or alcohol abuse within the past 2 years prior to screening. Positive drugs of abuse (DOA) including morphine, methamphetamine, ketamine, marijuana, methylenedioxymethamphetamin, and alcohol (unless can be explained by the participant's medications). Major surgery within 8 weeks prior to screening, or planned inpatient surgery or hospitalization during the study period. Donation of blood or blood products in excess of 400 mL within 3 months prior to screening and until the end of the follow-up period [Day 113]. Participants who have a positive test for, or have been treated for hepatitis B, hepatitis C, Syphilis or HIV. Regarding the hepatitis B testing (hepatitis B surface antigen [HBsAg], hepatitis B surface antibody [anti-HBs], hepatitis B core antibody [anti-HBc]), any of the following would exclude the participant from the study: Participants positive for HBsAg. Participants positive for anti-HBc. Participants with a history of hepatitis B vaccination without a history of Hepatitis B are permitted. Evidence of active or latent tuberculosis (TB): Positive diagnostic TB test during screening (defined as a positive interferon-gamma release assay [IGRA] test for TB at screening). Participants with an indeterminate IGRA should undergo repeat test and if still indeterminate may be enrolled only after treatment and subsequent negative IGRA. Evidence of active COVID-19 infection: Positive diagnostic COVID-19 PCR result Or Subject has severe COVID-19 infection as defined by positive COVID-19 PCR result and hospitalization or radiological evidence of pneumonia in the previous 6 months. Receiving any of the medications listed below: Any immunotherapy or immunosuppressive therapy (within 1 year prior to randomization). Chronic use of steroid medications. Investigational agents (within the last 3 months or at least 5 times the predicted half-life of the agent, whichever is greater). Marketed biologics, including omalizumab (within the last 3 months or at least 5 times the predicted half-life of the biologics, whichever is greater). Immunoglobulin or blood products (within 6 months prior or randomization). Live vaccines (until the end of the follow-up period [Day 113]). Treatment with broad spectrum antibiotic within 4 weeks prior to randomization (Day 1). Concurrent enrolment in another clinical study involving an investigational treatment. Received administration of an investigational drug or participated in a device trial within 3 months and 5.5 half-lives, prior to screening (Visit 1). History or current diagnosis of cancer, with the exception of cancer treated with apparent success with curative therapy (response duration of > 5 years). History of an underlying condition that predisposes the participant to infections (e.g., history of splenectomy, known primary or secondary immune deficiency syndromes). History of Inflammatory Bowel Disease or microscopic colitis. A known history of severe reaction to any medication including biologic agents and human gamma globulin therapy. History of allogeneic bone marrow transplant. History of a viral, bacterial, or fungal significant infection (including unexplained diarrhea) within 4 weeks (28 days) prior to randomization (Day 1) or clinical suspicion of infection at the time of dosing. History of herpes zoster within 3 months prior to randomization (Day 1). Participants with recent (within 12 months) clinical history of infective hepatitis or unexplained jaundice. Participant is a participating investigator, sub-investigator, study coordinator, or employee of the participating site, or is a first-degree relative of the aforementioned. Inability of the patient, in the opinion of the investigator, to understand and/or comply with study medications, procedures and/or follow-up or any conditions that, in the opinion of the investigator, may render the patient unable to complete the study.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: MEDI3506 dose 1<br>MEDI3506 dose1 | Biological: MEDI3506<br>* MEDI3506<br>|
| Experimental: MEDI3506 dose 2<br>MEDI3506 dose 2 | Biological: MEDI3506<br>* MEDI3506<br>|
| Placebo Comparator: Placebo<br>Placebo 2 mL and 4 mL | Drug: Placebo<br>* Placebo<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximum observed concentration (Cmax) | To assess the maximum plasma concentration of MEDI3506 after single subcutaneous administrations in healthy Chinese participants. | Day 1 to Day 113 | 
| Area under the serum concentration time curve to the infinite (AUC0-inf) | To assess the area under the serum concentration time curve from pre-dose until infinite after single Subcutaneous administration of MEDI3506 in healthy Chinese participants | Day 1 to Day 113 | 
| Area under the serum concentration time curve to the last observation(AUC0-t) | To assess the area under the serum concentration time curve from pre-dose until the last observation quantified after single Subcutaneous administration of MEDI3506 in healthy Chinese participants | Day 1 to Day 113 | 
| Terminal Elimination half-life (t1/2) | To assess the terminal elimination half-life after single Subcutaneous administration of MEDI3506 in healthy Chinese participants | Day 1 to Day 113 | 
| Apparent total body Clearance (CL/F) | To evaluate the apparent MEDI3506 total body clearance from serum after single subcutaneous administration of MEDI3506 in healthy Chinese participants | Day 1 to Day 113 | 
| Apparent volume of distribution based on terminal phase (Vz/F) | To assess the apparent volume of distribution of MEDI3506 after single subcutaneous administration of MEDI3506 in healthy Chinese participants | Day 1 to Day 113 | 
| Time to reach maximum observed concentration (tmax) | To assess the MEDI3506 time to reach peak serum concentration after single subcutaneous administration of MEDI3506 in healthy Chinese participants. | Day 1 to Day 113 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Immunogenicity determined by prevalence of antidrug antibodies (ADA) | Immunogenicity prevalence measured as number of participants with ADA positive at baseline and/or post-baseline | Day 1 (-30 0 min before IP administration), and on Day 8, Day 29, Day 57, Day 85 and Day 113 | 
| Immunogenicity determined by incidence of ADA | Immunogenicity incidence measured as number of participants with positive treatment emergent ADA | Day 1 (-30 0 min before IP administration), and on Day 8, Day 29, Day 57, Day 85 and Day 113 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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MEDI3506, Healthy Volunteers