Application of the Triple Stimulation Technique to Patients With CNS Disorders Including Stroke

Study Overview
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Brief Summary
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TST (Triple stimulation technique) helps to better quantify the proportion of motor units activated by transcranial magnetic stimulation. The abnormal amplitude registered by TST is proportional to the intensity of conduction disorders. The evaluation of these disorders is more precise with this technique than with the slowing of the central conduction time (CCT). The investigators propose to use this technique in CNS pathologies where this disorder is significant and essential, like multiple sclerosis and stroke.

Official Title
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Application of the Triple Stimulation Technique to Patients With CNS Disorders Including Stroke

Conditions
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Stroke Patients

Intervention / Treatment
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* Procedure: Triple stimulation technique


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: stroke patients with hemiparesia Exclusion Criteria: pace maker epilepsia metallic neurosurgical implants

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Stroke patients<br>The patients will be submitted to a triple stimulation examination. | Procedure: Triple stimulation technique<br>* Evoked motor potentials obtained by magnetic transcranial stimulation are usually used, in standard practice, to evaluate the corticospinal tract. This procedure combines two techniques: the magnetic stimulation and the electroneuromyography. It is based on the double collision principle between the descending central stimulation (magnetic) and the ascending peripheric stimulation, hereby suppressing the issue of desynchronisation of evoked motor potentials. The Triple stimulation technique allows a better quantification of the proportion of motor units activated by the transcranial stimulation.<br>|
| Active Comparator: Control Subjects<br>This group of patients did not suffer from a stroke. They will also be submitted to a triple stimulation examination. | Procedure: Triple stimulation technique<br>* Evoked motor potentials obtained by magnetic transcranial stimulation are usually used, in standard practice, to evaluate the corticospinal tract. This procedure combines two techniques: the magnetic stimulation and the electroneuromyography. It is based on the double collision principle between the descending central stimulation (magnetic) and the ascending peripheric stimulation, hereby suppressing the issue of desynchronisation of evoked motor potentials. The Triple stimulation technique allows a better quantification of the proportion of motor units activated by the transcranial stimulation.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Amplitude of the motor evoked potentials |  | during the TST (30 min) | 
| Surface of the motor evoked potentials |  | during the TST (30 min) | 
| Amplitude ratio of the TST |  | during the TST (30 min) | 
| Surface ratio of the TST |  | during the TST (30 min) | 
| TMS threshold |  | during TST (30 min) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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TST, TMS, Stroke patients, EMG