Audiometric Parameters in Conductive Hearing Loss and Middle Ear Disease

Study Overview
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Brief Summary
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We study audiometric parameters including Transient Otoacoustic emissions, pure-tone audiometry for air- and bone-conduction, and spondaic speech recognition thresholds for air- and bone conduction in a pre- and postoperative situation in patients due for surgery for tympanic membrane perforations and otosclerosis. The hypotheses are that the precision of the preoperative assessment may be increased, and our knowledge about the effect on the inner ear by middle ear surgery may be increased.

Detailed Description
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Consecutive patients 12 years or older due for myringoplasty or stapes surgery at the ENT-department, University hospital of Tromsø, in an approximate time span of one year, have been studied with the following audiometric investigations at the preoperative admission, 2, 6 and 12 months postoperatively: Transient otoacoustic emissions, pure-tone audiometry for air- and bone-conduction, speech audiometry using spondaic recognition for air and bone-conduction. Results will be statistically analysed using the Statistical Package for the Social Sciences, with the unoperated ear (paired organ) serving as controls. The goal is to look at alternative methods for analysing the patients' preoperative hearing in order to increase the precision of clinical decision-making. The secondary goal is to elucidate the effects of middle ear surgery on the inner ear.

Official Title
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Audiometric Parameters in Conductive Hearing Loss and Middle Ear Disease

Conditions
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Otosclerosis, Tympanic Membrane Perforation

Intervention / Treatment
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* Procedure: myringoplasty
* Procedure: Stapes surgery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Tympanic membrane perforation without chronic secretion or cholesteatoma Suspected otosclerosis Exclusion Criteria: Below 12 years of age Patient not consenting to study Perioperative findings suggesting chronic otitis or cholesteatoma Patients not fluent in Norwegian or unable to cooperate in audiometry

Ages Eligible for Study
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Minimum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Myringoplasty<br>Patients subject to myringoplasty for tympanic membrane perforations. | Procedure: myringoplasty<br>* Myringoplasty is an operative procedure to close tympanic membrane perforations.<br>|
| Otosclerosis<br>Patients subject to stapes surgery | Procedure: Stapes surgery<br>* Operative procedure aimed to replace non-functioning stapes with a synthetic prosthesis<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Post-operative hearing threshold level | Pure tone audiometry, speech audiometry, otoacoustic emissions | 1 year |