Assessing the Impact of Two Methods of Continuous Veno-venous Hemodiafiltration on Time Nursing Work in Intensive Care

Study Overview
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Brief Summary
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The prevalence of acute renal failure in intensive care is estimated at between 5 and 20% depending on diagnostic criteria retained. And half of patients require the use of hemodialysis. Continuous veno-venous hemodiafiltration (CVVHDF) is one of the hemodialysis technique widely used in intensive care unit. The CVVHDF is performed at the bedside, by a mobile generator with a semi permeable membrane, a blood circuit, a dialysate circuit and a feedback circuit. The implementation of a CVVHDF requires the use of large amounts of biological liquid essential to enable the purification of blood during its passage through the artificial kidney. The objective of this study is to assess time nursing work and the costs of each method.

Detailed Description
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The prevalence of acute renal failure in intensive care is estimated at between 5 and 20% depending on diagnostic criteria retained. And half of patients require the use of hemodialysis. Continuous veno-venous hemodiafiltration (CVVHDF) is one of the hemodialysis technique widely used in intensive care unit. The CVVHDF is performed at the bedside, by a mobile generator with a semi permeable membrane, a blood circuit, a dialysate circuit and a feedback circuit. The implementation of a CVVHDF requires the use of large amounts of biological liquid essential to enable the purification of blood during its passage through the artificial kidney. The biological fluid may be supplied to the generator of CVVHDF in 2 ways: The conventional method, the most used: the generator operates with pockets containing dialysis fluid, these pockets to be changed regularly by nurses The on-line method: the generator operates with a specific water system supplying the dialysis fluid available in every room of the unit The objective of this study is to assess time nursing work and the costs of each method. For this, 15 patients will be included in this study. Each patient performs 12 hours of each method (conventional and online), whose order will be randomized.

Official Title
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Assessing the Impact of Two Methods of Continuous Veno-venous Hemodiafiltration on Time Nursing Work in Intensive Care

Conditions
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Acute Renal Failure

Intervention / Treatment
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* Procedure: Continuous veno-venous haemodiafiltration


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient affiliated with or beneficiary of a social security category Patient with a renal failure requiring a CVVHDF for at least 2 cycles of 12 hours Exclusion Criteria: N/A
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: CVVHDF on-line<br>CVVHDF using a central water treatment plant, providing dialysate directly to the patient. They will perform a continuous veno-venous haemodiafiltration. | Procedure: Continuous veno-venous haemodiafiltration<br>* Dialysis procedure administrated to the patients with acute renal failure<br>* Other names: CVVHDF on-line : dialysate generator 5008 (Fresenius);|
| Experimental: classical CVVHDF<br>CVVHDF using a mobile generator with dialysate bags. They will perform a continuous veno-venous haemodiafiltration. | Procedure: Continuous veno-venous haemodiafiltration<br>* Dialysis procedure administrated to the patients with acute renal failure<br>* Other names: CVVHDF on-line : dialysate generator 5008 (Fresenius);|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| time of nursing work required to realised a CVVHDF as a conventional and on line methods modality of supply compared to a method on-line | The end of the study for the patient corresponds to the end of CVVHDF conventional and on line. | Day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| costs of CVVHDF performed using a conventional and on-line methods | The end of the study for the patient corresponds to the end of CVVHDF conventional and on line. | Day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hemodiafiltration, cost, dialysis solution, acute renal failure, intensive care unit