Prevalence Of COVID-19 Among Health-workers in a French General Hospital

Study Overview
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Brief Summary
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The aim of this study is to evaluate the prevalence of COVID-19 among the workers of our hospital and the factors that are likely to influence this prevalence. It must be underlined that our hospital is settled in two towns and both hospital sites had different missions regarding the admissions of COVID-19-infected patients.

Detailed Description
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Since December 2019, the COVID-19 pandemic has widespread from China and put under strong tension the health organizations throughout the world, especially since march 2020 in France. As a consequence, the French hospitals had to cope with a massive amount of COVID-19 infected patients and, thus, their organisations had to evolve in order to be able to admit more patients in their critical care units. First studies reported an important level of inter-human contagiousness of the SARS-CoV-2 virus with an R0 (basic reproduction number) superior to 3, which could lead to a massive contamination of healthcare workers since they are directly in charge of infected patients. Other studies suggested that the healthcare workers are more likely to be contaminated by the COVID-19 than the rest of the population, which pushed governments and hospital managers to put in place individual and collective measures of protection in order to avoid nosocomial transmissions and also to preserve the health of the hospital staffs in a context of high tension on the hospital work force. There are today few data about the contamination level among the healthcare workers of general hospitals in France and about the severity of these contaminations. A national study is being conducted but on a macroscopic regional scale. In addition to that, the proportion of asymptomatic SARS-CoV-2 contaminated healthcare workers is not known as well as the origin (hospital or community) of the contaminations. In June 2020, the French Health Ministry decided to launch a collection of epidemiological data in the French hospitals based on serologic tests. Thanks to this action and with the results of all the RT PCR tests systematically conducted since the beginning of the pandemic when a healthcare worker had COVID-19-like symptoms, the Centre Hospitalier Sud Essonne has decided to conduct an observational study. The aim of this study is to evaluate the prevalence of COVID-19 among the workers of our hospital and the factors that are likely to influence this prevalence. It must be underlined that our hospital is settled in two towns and both hospital sites had different missions regarding the admissions of COVID-19-infected patients.

Official Title
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Prevalence Of COVID-19 Among Health-workers in a French General Hospital

Conditions
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Covid19

Intervention / Treatment
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* Diagnostic Test: Serelogy testing, RT PCR


Participation Criteria
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Eligibility Criteria
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Inclusion criteria: hospital staff working at the Centre Hospitalier Sud Essonne, employed by the Centre Hospitalier Sud Essonne between March, 5th, 2020, and August, 31rst, 2020, with the result of an RT PCR test or a serologic test, this (these) result(s) must have been/be communicated to the occupational health service of the hospital. Exclusion criteria: interim workers, workers in holidays during the entire period of inclusion above, opposition to participate in this study.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Serelogy testing, RT PCR|Serology testing for all the participants and RT PCR for participants with symptoms|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| General prevalence of COVID-19 | measures the prevalence of COVID-19 among the healthcare workers of the Centre Hospitalier Sud Essonne, defined as the hospital employees with positive serologic or RT-PCR tests. It must be underlined that the notion of health workers include the entire hospital staff ie doctors, nurses, administrative employees,... | Through study completion, an average of 9 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of asymptomatic healthcare workers | no RT PCR or negative RT PCR and positive serologic test, positive RT PCR and no symptoms, | Through study completion, an average of 9 months | 
| Number of symptomatic healthcare workers | Positive RT-PCR test or serologic test with symptoms. | Through study completion, an average of 9 months | 
| Number of healthcare workers with a severe form of COVID-19 which led to an hospitalization | Positive serologic or RTC-PCR test and hospitalization | Through study completion, an average of 9 months | 
| Number of healthcare workers infected with COVID-19 and hospitalized in a critical care unit | Positive serologic or RTC-PCR test and hospitalization in a critical care unit | Through study completion, an average of 9 months | 
| Influencing factors of the prevalence of the COVID-19 among healthcare workers | age, gender, job, duration of employment in the hospital, hospital site of affectation, unit of affectation. | Through study completion, an average of 9 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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health-workers, COVID19, hospital, SARS-CoV-2, prevalence