Benefits and Risks of Artificial Light Exposure: Characterisation of Effects on Alertness, Sleep, Cognitive Performance, Mood and Biological Rhythms

Study Overview
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Brief Summary
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The purpose of this project is to study the influence of light on sleep, wakefulness, EEG activity and cognitive performances.

Official Title
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Benefits and Risks of Artificial Light Exposure: Characterisation of Effects on Alertness, Sleep, Cognitive Performance, Mood and Biological Rhythms

Conditions
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Human Sleep and Chronobiology

Intervention / Treatment
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* Device: polychromatic light
* Device: polychromatic light
* Device: red light
* Device: red light
* Device: green light
* Device: green light


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male or female Aged 18 to 40 years With a hint of Bodymass index (BMI) between 17 and 30 kg.m - 2 healthy subject determined by a clinical examination, a psychological interview, a blood test, a urine analysis Subject with a score<6 questionnaire PSQI (Sleep Questionnaire Pittsburgh) Subject agreeing to maintain a regular sleep/wake rhythm during the study Subject agreeing to refrain from caffeine, nicotine, alcohol, psychotropic drugs, cannabis or other drugs, during the study Signed informed consent Subjectaffiliated to a social protection scheme Exclusion Criteria: somatic diseases: cardiovascular, respiratory, gastrointestinal, hematopoietic, Visual immune system diseases kidneys and urinary tract diseases endocrine and metabolic diseases neurological diseases infectious diseases thrombocytopenia or other malfunction of blood platelets Subject with risk of thrombosis, including subject with a history of phlebitis, smoker under oral contraceptive... Subject with an addiction to caffeine, nicotine, alcohol, psychotropic drugs, cannabis, or any other drug Subject treatment contraindicated or inadvisable in combination with heparin blood donation in the previous 3 months before the inclusion Participation in other clinical trials Work by shifts in the year preceding the inclusion Trans-meridian travel (> 2 time zones) in the month previous the inclusion Impossibility to give enlightened information (subject in an emergency situation, understanding difficulties,...) Subject under safeguard of justice Subject under tutorship or curatorship Pregnancy (women of childbearing age) Breastfeeding Diet incompatible with the study's snack choices

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Wp<br> | Device: polychromatic light<br>* Application of polychromatic light at different times of day<br>|
| Active Comparator: Wn<br> | Device: polychromatic light<br>* Application of polychromatic light for 2h30 at different times of day with sleep<br>|
| Active Comparator: Gn<br> | Device: green light<br>* Application of green light at different times of day with sleep<br>|
| Active Comparator: Gp<br> | Device: green light<br>* Application of green light at different times of day<br>|
| Active Comparator: Rp<br> | Device: red light<br>* Application of red light at different times of day<br>|
| Active Comparator: Rn<br> | Device: red light<br>* Application of red light at different times of day with sleep<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognitive performances assessed using N-back tasks | N-Back-Task 1, 2, 3 | up to 56 hours | 
| Cognitive performances assessed using Psychomotor Vigilance task (PVT) | Psychomotor Vigilance task (PVT) | up to 56 hours | 
| Cognitive performances assessed using Paced Visual Serial Addition Task (PVSAT) | Paced Visual Serial Addition Task (PVSAT) | up to 56 hours |