Rapid Screening for Olfactory Disorders in Covid-19 Infection

Study Overview
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Brief Summary
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Loss of smell is very frequently found in Europe during Covid-19 attack. This symptom was not initially expected as part of the classic symptomatology. This loss of smell mainly concerns patients with few or no symptoms, without criteria of severity and usually treated on an outpatient basis. As a result, given the unexpected occurrence of this symptom (with less awareness in the general and medical population) and the potential risk of contamination of Covid+ and anosmic subjects (due to their less symptomatic form), it is interesting to be able to propose large-scale screening for loss of sense of smell in order to preferentially direct subjects diagnosed as anosmic towards RT-PCR-type screening. In the medium term, the loss of smell seems to persist after the infectious phase, with delayed or persistent recovery, which can lead to negative psychological repercussions. The objective is to propose large-scale screening of the general population for loss of sense of smell during a pandemic period, in order to facilitate diagnostic orientation of the population. The diagnosis of loss of smell will be carried out using a simple olfactory test in the form of an olfactory stick to be smelled.

Official Title
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Rapid Screening for Olfactory Disorders in Covid-19 Infection

Conditions
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Olfaction Disorders, COVID-19 Testing

Intervention / Treatment
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* Diagnostic Test: Olfactory test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subject presenting himself at the covid-19 screening centre set up by the city of Nice Exclusion Criteria: Presence of a sensory deficit (auditory or visual) preventing the subject from answering the questions perfectly during the olfactory test. Subject receiving cancer chemotherapy

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Olfactory test<br>The result of the olfactory test will be compared to the result of the RT-PCR test. | Diagnostic Test: Olfactory test<br>* The olfactory test (Olfascan) is in the form of a paper stick, previously impregnated with an odorant (non-liquid). It is placed a few centimetres from the participant's nose at the time of the test. It is a single-use test, without contact with the participant.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Olfactory test | Sensitivity of the olfactory test (Olfascan) for measuring anosmia, compared to the reference diagnostic test (RT-PCR analysis). | Day 0 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Olfaction Disorders, Hyposmia, Dysosmia, Anosmia, Covid-19