Fasted Exercise in People With Type 1 Diabetes

Study Overview
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Brief Summary
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This study aims to compare the effect of a bout of high-intensity interval training (HIT) with a bout of moderate-intensity continuous training (MICT) on glucose concentrations over the subsequent 24h period.

Detailed Description
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This study aims to compare the effect of a bout of high-intensity interval training (HIT) with a bout of moderate-intensity continuous training (MICT) on glucose concentrations over the subsequent 24h period. Fourteen people with type 1 diabetes (duration of type 1 diabetes 8.2±1.4 years), all on basal-bolus regimen, completed a randomised, counterbalanced, crossover study. Continuous glucose monitoring was used to assess glycaemic control following a single bout of HIT (6 x 1min intervals) and 30 mins of moderate-intensity continuous training (MICT) on separate days, compared to a non-exercise control day (CON). Exercise was undertaken following an overnight fast with omission of short-acting insulin. Capillary blood glucose samples were recorded pre and post-exercise to assess the acute changes in glycaemia during HIT and MICT.

Official Title
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Fasted High-Intensity Interval and Moderate-Intensity Continuous Exercise Are Not Associated With A Detrimental 24-Hour Blood Glucose Profile

Conditions
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Type1diabetes

Intervention / Treatment
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* Behavioral: Effects of the type of exercise on blood glucose concentrations


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: duration of type 1 diabetes >6 months basal bolus regimen no significant history of hyper- or hypoglycaemia (determined from medical history Exclusion Criteria: duration of type 1 diabetes <6 months, insulin pump therapy significant history of hyper- or hypoglycaemia (determined from medical history) obesity (BMI >30 kg∙m-2) pregnancy or planning pregnancy, uncontrolled hypertension (>180/100 mmHg) angina autonomic neuropathy taking any medication that affects heart rate major surgery planned within 6 weeks of the study severe nonproliferative and unstable proliferative retinopathy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Control day with no exercise<br>glycaemic profile will be assessed using continuous glucose monitors following a single 24-hour period in which participants performed no exercise | Behavioral: Effects of the type of exercise on blood glucose concentrations<br>* glucose concentrations were assessed over the 24 hour periods following no exercise, a single bout of high intensity interval training and a single bout of moderate intensity continuous training<br>|
| Experimental: High intensity interval training (HIT)<br>glycaemic profile will be assessed using continuous glucose monitors following a 24-hour period whereby participants performed a single bout of high-intensity interval training (HIT) in the morning under fasted conditions | Behavioral: Effects of the type of exercise on blood glucose concentrations<br>* glucose concentrations were assessed over the 24 hour periods following no exercise, a single bout of high intensity interval training and a single bout of moderate intensity continuous training<br>|
| Experimental: moderate intensity continuous training (MICT)<br>glycaemic profile will be assessed using continuous glucose monitors following a 24-hour period whereby participants performed a single bout of moderate-intensity continuous training (MICT) in the morning under fasted conditions | Behavioral: Effects of the type of exercise on blood glucose concentrations<br>* glucose concentrations were assessed over the 24 hour periods following no exercise, a single bout of high intensity interval training and a single bout of moderate intensity continuous training<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 24 hour glycaemic profile | Continuous glucose monitoring will be used to assess the effects of an acute bout of fasted high intensity interval training or moderate intensity continuous training on 24 hour glycaemic profile. | 24 hours |