Effect of American Ginseng on Exercise-induced Muscle Soreness

Study Overview
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Brief Summary
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Healthy participants will ingest American ginseng daily or a placebo for four weeks prior to engaging in a unaccustomed exercise bout designed to induce mild-moderate muscle soreness. Muscle soreness will be assessed via decrements in muscle strength and with a self-rating of perceived soreness before and several times after the exercise.

Detailed Description
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Healthy men and women will consume either 2000 mg of American ginseng daily (four 500 mg pills will be taken at four different times during the day always with food/meals) or a placebo (4 cellulose) for four weeks prior to engaging in a 40 minute downhill treadmill jog (12% decline) at a speed of 7 miles per hour. Participants will consume one pill with breakfast, one pill with lunch, one pill with dinner and another pill with a snack either between meals or prior to bedtime. The exercise will be consist of five, eight minute bouts of jogging with two minutes of rest/recovery in between. The degree of muscle soreness will be assessed using a Biodex strength testing machine (isometric and concentric isokinetic torque), and a self-rating of perceived soreness on a scale from zero to ten. All of the above measures will be taken before and several times after the downhill jogging protocol.

Official Title
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Effect of American Ginseng on Exercise-induced Muscle Soreness

Conditions
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Muscle Damage

Intervention / Treatment
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* Dietary Supplement: Ginseng


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy men or women, (women must weigh between 55-65 kg., while men must weigh between 75-85kg). Participants must not have engaged in any endurance run training in the past 9 months. Exclusion Criteria: Injured Regular runners Pregnant (or with any chance they may become pregnant) Breast-feeding Diabetics or those taking medication for diabetes Insomniacs Schizophrenics Hyper- or hypotension Cancer Irregular heartbeats Heart disease Females with endometriosis or uterine fibroids Those who have surgery scheduled during the study or within the two weeks following the completion of the study Those taking warfarin or medication for depression.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Treatment<br>American Ginseng ingestion | Dietary Supplement: Ginseng<br>* Effect of four weeks of daily Ginseng intake (2gm/day) on muscle soreness following downhill running exercise<br>|
| Placebo Comparator: Placeobo<br>non-active ingredient | Dietary Supplement: Ginseng<br>* Effect of four weeks of daily Ginseng intake (2gm/day) on muscle soreness following downhill running exercise<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| muscle strength | ginseng & muscle strength | 1 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Muscle, Soreness, Muscle function, Damage, Ginseng