Saliva Levels of S100A12, CRP, Fetuin-A in Periodontal Disease Patients

Study Overview
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Brief Summary
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Hs-CRP, Fetuin-A and S100A12 are acute phase proteins associated with many systemic diseases and conditions. The aim of this study was to determine the clinical parameters and salivary Hs-CRP, Fetuin-A and S100A12 levels before and after non-surgical periodontal treatments in the patients with periodontal diseases. A total of 54 subjects were divided in to three groups; periodontally healthy (n: 18), gingivitis (n: 18), chronic periodontitis (n: 18). Clinical periodontal parameters, salivary Hs-CRP, Fetuin-A and S100A12 levels and salivary flow rates were evaluated at baseline and a month after the treatments. Salivary Hs-CRP, Fetuin-A and S100A12 levels were assayed by ELISA.

Official Title
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The Short-Term Effects of Non-Surgical Periodontal Therapy on The Saliva Levels of S100A12, High-Sensitivity C-Reactive Protein and Fetuin-A in Patients With Gingivitis and Chronic Periodontitis

Conditions
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Periodontal Inflammation

Intervention / Treatment
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* Diagnostic Test: salivary samples


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: never-smokers no history of systemic disease no patients had been under periodontal therapy and medicine for at least 6 months before the study no pregnancy or lactation no alcohol or antioxidant vitamin consumption. Exclusion Criteria: -
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Periodontally healthy subjects<br>Salivary samples | Diagnostic Test: salivary samples<br>* Salivary Hs-CRP, Fetuin-A and S100A12 levels and salivary flow rates were evaluated at baseline and a month after the treatments<br>|
| Chronic periodontitis patients<br>Salivary samples | Diagnostic Test: salivary samples<br>* Salivary Hs-CRP, Fetuin-A and S100A12 levels and salivary flow rates were evaluated at baseline and a month after the treatments<br>|
| Gingivitis patients<br>Salivary samples | Diagnostic Test: salivary samples<br>* Salivary Hs-CRP, Fetuin-A and S100A12 levels and salivary flow rates were evaluated at baseline and a month after the treatments<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Salivary acute phase proteins | Fetuin-A | Baseline - a month after the periodontal treatments | 
| Salivary acute phase proteins | S100A12 | Baseline - a month after the periodontal treatments | 
| Salivary acute phase proteins | C-Reactive Protein | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluating periodontal health | plaque index | Baseline - a month after the periodontal treatments | 
| Evaluating periodontal health | gingival index | Baseline - a month after the periodontal treatments | 
| Evaluating periodontal health | probing depth | Baseline | 
| Evaluating periodontal health | clinical attachment level | Baseline - a month after the periodontal treatments | 
| Evaluating periodontal health | gingival bleeding on probing | Baseline - a month after the periodontal treatments | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Fetuin-A, S100A12, C-Reactive Protein, Chronic Periodontitis