Evaluation of Nail Fold Microcirculation in CKD

Study Overview
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Brief Summary
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To evaluation of nailfold microcirculation in patients with chronic renal failure and its intervention therapy

Detailed Description
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The aim of this study is to study the changes of Nailfold Microcirculation in patients with chronic renal failure, to clarify the correlation between the changes of Nailfold Microcirculation and renal function, and to explore whether nailfold microcirculation can be used as an indicator of renal microcirculation in patients with chronic renal failure, and to provide a noninvasive method for the clinical evaluation of renal microcirculation in patients with chronic renal failure.

Official Title
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Evaluation of Nail Fold Microcirculation and Interventional Therapy in Patients With Chronic Renal Failure

Conditions
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Chronic Renal Disease

Intervention / Treatment
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* Drug: Alprostadil Injection
* Drug: Beraprost sodium tablets


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: CKD patients Without dialysis Blood pressure ≤ 140/90mmHg Exclusion Criteria: Polycystic kidney Endocrine system disease Cardio-cerebrovascular disease Rheumatic immune disease Peripheral vascular disease Hematological diseases Respiratory disease Infection

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Experimental group<br>Alprostadil and Beraprost sodium tablets are used to improve the microcirculation of CKD patients. | Drug: Alprostadil Injection<br>* Participants are given alprostadil injection 10ug intravenously once a day for 2 weeks.<br>Drug: Beraprost sodium tablets<br>* Participants are given alprostadil injection 10ug intravenously once a day for 2 weeks ,then they take beraprost sodium tablets 40ug orally three times perday for 3 months.<br>|
| No Intervention: Anemia control group<br>Anemia patients | |
| No Intervention: Control group<br>Healthy person | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nailfold microcirculation morphological integral | Nail fold capillary microscopy examination | Up to three and a half months | 
| Nailfold microcirculation blood flow integral | Nail fold capillary microscopy examination | Up to three and a half months | 
| Nail fold microcirculation perivascular loop integral | Nail fold capillary microscopy examination | Up to three and a half months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The content of blood serum creatinine | Intravenous blood sampling | Up to three and a half months | 
| The content of blood urea nitrogen | Intravenous blood sampling，uronoscopy | Up to three and a half months | 
| The content of blood cystatin C | Intravenous blood sampling | Up to three and a half months | 
| eGFR | Intravenous blood sampling | Up to three and a half months | 
| The content of blood albumin | Intravenous blood sampling | Up to three and a half months | 
| The quantification of urinary protein | Uronoscopy | Up to three and a half months | 
| The content of hemoglobin | Intravenous blood sampling | Up to three and a half months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Chronic Renal Disease, Nail fold microcirculation, Interventional therapy