Antibiotic Resistant Bacteria Among Patients With Severe Intraabdominal Infections

Study Overview
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Brief Summary
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The objectives of the study were: To study risk factors for colonization and infection with antibiotic resistant bacteria among patients with severe IAI before and after antibiotic treatment and surgical intervention. To study species changes in the rectal flora among patients with severe IAI before and after antibiotic treatment and surgical intervention. To review guidelines for antibiotic use in participating units. To evaluate surgical antibiotic prophylaxis and treatment in relation to risk for colonization and infection with antibiotic resistant bacteria among patients with severe IAI To use the results from the study in the process of a more appropriate use of antibiotics in participating units and care of patients with severe IAI. To study the dynamics of extended-spectrum beta-lactamase producing and wild-type Enterobacteriaceae in patients with suspected severe intra abdominal infections before, during and after antibiotic treatment.

Detailed Description
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In order to evaluate if standard empirical treatment was adequate in relation to resistance pattern among most prevalent species at admission we need another 70 patients to be included with at least data and cultures from admission.

Official Title
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Risk Factors for Colonization and Infection With Antibiotic Resistant Bacteria Among Patients With Severe Intraabdominal Infections (IAI). An Open Observational Study

Conditions
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Complicated Intra-Abdominal Infections

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with evidence of intra-abdominal infections that require surgical intervention will be eligible. In addition will patients with intra-abdominal abscess confirmed with CT/ultrasound be eligible, but not treated with surgical intervention if estimated to require at least 5 days antibiotic treatment, with a severity needing initial intravenous administration of antibiotics. Exclusion Criteria: Age under 18 years

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Primary End points for detection of AB-R Colonising index: (a) Proportion of patients colonised with AB-R strains per bacteria species.(b)Proportion of colonising cultures containing AB-R strains per bacteria species. |  | 48 hours - 2 weeks after end of antibiotic treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of patients with SSI other postoperative infections caused by AB-R strains, per infection type and per bacteria species. |  | 48 hours - 2 weeks after end of antibiotic treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Antibiotic resistance, Antibiotic treatment