Oblimersen, Rituximab and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Aggressive Non-Hodgkin's Lymphoma

Study Overview
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Brief Summary
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This phase I/II trial is studying the side effects and best dose of oblimersen when given together with rituximab and combination chemotherapy and to see how well they work in treating patients with relapsed or refractory aggressive non-Hodgkin's lymphoma. Monoclonal antibodies such as rituximab can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. Drugs used in chemotherapy, such as ifosfamide, carboplatin, and etoposide, work in different ways to stop cancer cells from dividing so they stop growing or die. Oblimersen may increase the effectiveness of chemotherapy by making cancer cells more sensitive to the drugs

Detailed Description
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PRIMARY OBJECTIVES: I. Determine the maximum tolerated dose of oblimersen when given in combination with rituximab, ifosfamide, carboplatin, and etoposide in patients with relapsed or refractory aggressive B-cell non-Hodgkin's lymphoma. II. Determine the safety and toxicity of this regimen in these patients. III. Determine the complete and partial response rate in patients treated with this regimen. SECONDARY OBJECTIVES: I. Determine the duration of response, overall survival, and time to progression in patients treated with this regimen. II. Determine the effect of this regimen on hematopoietic stem cell kinetics and yield from these patients. OUTLINE: This is a multicenter, phase I, dose-escalation study of oblimersen followed by a phase II study. Phase I: Patients receive GRICE comprising oblimersen IV continuously on days 1-5, rituximab IV, ifosfamide IV continuously over 24 hours, and carboplatin IV over 1 hour on day 4, and etoposide IV over 30 minutes once daily on days 4-6. Treatment repeats every 14 days for 3 courses. Patients also receive filgrastim (G-CSF) subcutaneously (SC) once daily beginning on day 7 and continuing until blood counts recover OR one dose of pegfilgrastim SC on day 7 of courses 1 and 2. For course 3, all patients receive G-CSF SC twice daily beginning on day 7 and continuing until stem cell collection is complete. Patients with responding disease who are not eligible for autologous SCT may receive up to 8 total courses of GRICE or 2 additional courses beyond maximal response. Patients with responding disease to GRICE who are eligible for autologous SCT are removed from the study and undergo autologous SCT off study. Cohorts of 3-6 patients receive escalating doses of oblimersen until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. Phase II: Patients receive oblimersen at the MTD determined in phase I and rituximab, ifosfamide, carboplatin, and etoposide followed by G-CSF or pegfilgrastim as in phase I. In both phases, treatment continues in the absence of disease progression, unacceptable toxicity, or the patient becomes a candidate for autologous SCT. Patients are followed for survival.

Official Title
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A Phase I/II Study of G3139 (Genasense) in Combination With RICE Chemotherapy in Relapsed B-Cell Non-Hodgkin's Lymphoma

Conditions
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Recurrent Adult Diffuse Large Cell Lymphoma, Recurrent Grade 3 Follicular Lymphoma, Recurrent Mantle Cell Lymphoma

Intervention / Treatment
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* Biological: oblimersen sodium
* Biological: rituximab
* Drug: ifosfamide
* Drug: carboplatin
* Drug: etoposide
* Biological: filgrastim
* Biological: pegfilgrastim
* Other: laboratory biomarker analysis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Histologically confirmed aggressive B-cell non-Hodgkin's lymphoma Any 1 one of the following histological subtypes for phase I: Grade 3 follicular center lymphoma Diffuse large B-cell lymphoma Transformed follicular lymphoma Mantle cell lymphoma Primary mediastinal B-cell lymphoma Any 1 of the following histological subtypes for phase II: Diffuse large B-cell lymphoma Transformed follicular lymphoma Primary mediastinal B-cell lymphoma Measurable disease At least 1 bidimensionally measurable lesion ≥ 10 mm in longest diameter by CT scan, MRI, x-ray, or clinical exam Relapsed disease after 1, and only 1, prior anthracycline-based chemotherapy regimen No known brain metastases Performance status - ECOG 0-2 Performance status - Karnofsky 60-100% More than 3 months Absolute neutrophil count ≥ 1,000/mm^3* Platelet count ≥ 100,000/mm^3* Bilirubin normal** AST and ALT ≤ 2.5 times upper limit of normal PT and PTT normal Creatinine normal Creatinine clearance ≥ 60 mL/min No symptomatic congestive heart failure No unstable angina pectoris No cardiac arrhythmia Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception No history of allergic reactions attributed to compounds of similar chemical or biological composition to oblimersen or other study drugs No currently active second malignancy except nonmelanoma skin cancer or carcinoma in situ of the cervix Must have completed any prior therapy for a second malignancy and is considered to be at < 30% risk of relapse No ongoing or active infection No psychiatric illness or social situation that would preclude study compliance No other concurrent uncontrolled illness Prior rituximab allowed No other concurrent immunotherapy See Disease Characteristics At least 4 weeks since prior cytotoxic chemotherapy (6 weeks for nitrosoureas or mitomycin) and recovered No other concurrent chemotherapy No concurrent hormonal therapy At least 4 weeks since prior radiotherapy and recovered No concurrent therapeutic radiotherapy At least 4 weeks since prior surgery No prior oblimersen or other antisense oligonucleotide therapy No other concurrent anticancer agents or therapies No concurrent combination antiretroviral therapy for HIV-positive patients No other concurrent investigational agents

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Treatment (genase, combination chemotherapy)<br>See detailed description. | Biological: oblimersen sodium<br>* Given IV<br>* Other names: Genasense;Biological: rituximab<br>* Given IV<br>* Other names: Rituxan;Drug: ifosfamide<br>* Given IV<br>* Other names: IPP;Drug: carboplatin<br>* Given IV<br>* Other names: Paraplatin;Drug: etoposide<br>* Given IV<br>* Other names: VP-16-213;Biological: filgrastim<br>* Given SC<br>* Other names: Neupogen;Biological: pegfilgrastim<br>* Given SC<br>* Other names: SD-01 sustained duration G-CSF;Other: laboratory biomarker analysis<br>* Correlative studies<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Toxicity graded using the NCI CTCAE version 3.0 |  | Up to 3 years | 
| Complete and partial response rate according to the International Workshop Criteria |  | Up to 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of response |  | From the time measurement criteria are met for CR/CRu/PR until the first date that PD is objectively documented, assessed up to 3 years | 
| Overall survival |  | From the first day of therapy to the date of death, assessed up to 3 years | 
| Time to progression |  | From the first day of treatment until the date PD or death is first reported, assessed up to 3 years |