Heart Rate and Initial Presentation of Cardiovascular Diseases (Caliber)

Study Overview
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Brief Summary
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Study of heterogeneity in associations between heart rate and the initial presentation of 12 cardiovascular diseases.

Detailed Description
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This study is part of the CALIBER (Cardiovascular disease research using linked bespoke studies and electronic records) programme funded over 5 years from the NIHR and Wellcome Trust. The central theme of the CALIBER research is linkage of the Myocardial Ischaemia National Audit Project (MINAP) with primary care (GPRD) and other resources. The overarching aim of CALIBER is to better understand the aetiology and prognosis of specific coronary phenotypes across a range of causal domains, particularly where electronic records provide a contribution beyond traditional studies. CALIBER has received both Ethics approval (ref 09/H0810/16) and ECC approval (ref ECC 2-06(b)/2009 CALIBER dataset).

Official Title
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Heterogeneity in Association of Heart Rate and Initial Presentation of Cardiovascular Diseases Using Linked Electronic Health Records

Conditions
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Abdominal Aortic Aneurysm, Coronary Heart Disease NOS, Unheralded Coronary Death, Intracerebral Haemorrhage, Heart Failure, Ischemic Stroke, Myocardial Infarction, Stroke, Peripheral Arterial Disease, Stable Angina Pectoris, Subarachnoid Haemorrhage, Transient Ischemic Attack, Unstable Angina, Cardiac Arrest, Sudden Cardiac Death

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: One year prior to study entry (up-to-standard follow-up, CPRD quality research standard). > 30 years old have at least a recorded heart rate measurement during the study period Exclusion Criteria: - Evidence of prior atherosclerotic or cardiac disease

Ages Eligible for Study
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Minimum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Risk of atherosclerotic disease in patients with high or low heart rate | Hazard ratios will be also presenting associations between heart rate and initial presentation of different cardiovascular diseases. These associations will be also measured between different levels of heart rate and CVDs stratified by: by sex gender a range of risk factors (such as physical activity, smoking status, drinking status, etc.) | Participants were followed until the first Coronary disease event (an expected average of 5 years) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence proportions and life time risk for Cardiovascular diseases | Subhazard Ratios and Cumulative Incidence estimation of the risk of 12 different cardiovascular diseases adjusted for the 4 different levels of heart rate (<60, 60-74, 75-89, >90), age and sex in a lifetime period | Participants were followed until the first Coronary disease event (an expected average of 5 years) |