Energy Homeostasis in Anorexia Nervosa

Study Overview
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Brief Summary
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The purpose of this study is to investigate the potential biological predispositions that contribute to the difficulty patients with anorexia nervosa have in maintaining normal weight.

Detailed Description
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Anorexia Nervosa (AN) is a psychiatric illness that is characterized by extreme weight loss and severe body image distortions. In this study, we are examining changes in body composition, metabolic rate, and reproductive function before and after treatment for AN. More specifically, we are testing the hypotheses that 1)Weight-restored patients with AN have elevated resting energy expenditure (REE) compared to controls, 2) Weight-restored patients with AN have a central disposition of body fat compared to controls, 3) Weight-restored patients with AN who gain the most fat centrally will have the least improvement on psychological measures, 4) Weight-restored patients with AN will have leptin levels out of proportion to body fat mass. It will also investigate the relationship between REE and leptin with respect to the return of menses.

Official Title
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Energy Homeostasis in Anorexia Nervosa

Conditions
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Anorexia Nervosa

Participation Criteria
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Eligibility Criteria
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Patients: Inclusion Criteria: DSM-IV diagnosis of Anorexia Nervosa BMI ≤ 17.5kg/m2 (equivalent to 80% of ideal body weight) Medically stable Participation in in-patient treatment sufficient to restore patient to a BMI of at least 19kg/m2 Exclusion Criteria: On medication* Current substance abuse or dependence History of suicide attempt or other self-injurious behavior within the previous 6 months Non-removable metal on/in their body (e.g. metal pacemaker, surgical clips, metallic-ink tattoos) Controls: Inclusion criteria: No current psychiatric disorder (including eating disorder, depression, bipolar disorder, schizophrenia, substance abuse/dependence) No history of an eating disorder BMI greater than 19kg/m2 and less than 21kg/m2 Weight stable (+/- 2kg) for the previous 6 months No history of excessive or repeated dieting No history of excessive exercise (defined as greater than 6 hours/week) Regular menstrual cycles Exclusion criteria: On medication* Pregnant or lactating Significant medical problem Non-removable metal on/in their body (e.g. metal pacemaker, surgical clips, metallic-ink tattoos) At the time of testing, subjects will be free of fluoxetine for 6 weeks, and free of all other medications for a minimum of 2 weeks

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Anorexia Nervosa, Body Composition, Metabolic Rate