Acute Effect of Agiotensin-(1-7) in Healthy and Hypertensive Subjects

Study Overview
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Brief Summary
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In the modern concept of Renin-angiotensin System, Angiotensin-(1-7) plays a key role and demonstrates promising therapeutic potential due to it is generally opposite effects to Angiotensin II. The aim is to evaluate the effect of Ang-(1-7) acute administration on systolic and diastolic blood pressure (SBP and DBP) and heart rate (HR) in healthy and hypertensive subjects.

Official Title
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Acute Effect of Agiotensin-(1-7) on Bood Pressure and Heart Rate in Healthy and Hypertensive Subjects

Conditions
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Hypertension

Intervention / Treatment
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* Drug: Angiotensin 1-7
* Other: Placebo


Participation Criteria
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Eligibility Criteria
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Healthy Group Inclusion Criteria: arterial pressure <140/90 mmHg body mass index (BMI) between 18,5 and 29 Kg/m2 Hypertensive Group Inclusion Criteria: anti-hypertensive drug treatment ambulatory blood pressure monitoring (ABMP) >130/85 mmHg body mass index between 18,5 and 29 Kg/m2 Healthy Group Exclusion Criteria: drug treatment recent surgeries pregnancy previous cardiovascular events high performance athletes dislipidemia diabetes renal injury obesity (BMI above 30 kg/m2) alcoholism smoking. Hypertensive Group Exclusion Criteria: recent surgeries pregnancy beta-blockers drug treatment previous cardiovascular events high performance athletes dislipidemia diabetes renal injury obesity (BMI above 30 kg/m2) alcoholism smoking

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Healthy Subjects<br>Placebo and Angiotensin-(1-7) acute infusion | Drug: Angiotensin 1-7<br> <br> * Other names: Angio-1-7;Other: Placebo<br> <br> |
| Experimental: Hypertensive Subjects<br>Placebo and Angiotensin-(1-7) acute infusion | Drug: Angiotensin 1-7<br> <br> * Other names: Angio-1-7;Other: Placebo<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Absence of adverse effects after Ang-(1-7) acute administration |  | Along 25 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood Pressure Changes after Ang-(1-7) administration | absence of measure changes in blood pressure or heart rate (increase or decrease) | Recording along 24 hours | 
| Ang-(1-7) effects on Blood Pressure Variability | Response of autonomic nervous system, registered for 1 hours, after Ang-(1-7) acute administration | Along 1 hours after Ang-(1-7) acute administration | 
| Heart Rate Changes after Ang-(1-7) administration |  | Recording along 24 hours | 
| Ang-(1-7) effects on Heart Rate Variability | Response of autonomic nervous system, registered for 1 hours, after Ang-(1-7) acute administration | Along 1 hours after Ang-(1-7) acute administration | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Angiotensin-(1-7), Renin-angiotensin System, Autonomic Nervous System