Preoperative Carbohydrate Loading in Patients Undergoing Day-case Cholecystectomy

Study Overview
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Brief Summary
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Background: Preoperative carbohydrate loading has been shown to reduce preoperative discomfort and postoperative nausea and vomiting in general surgical patients. Few studies have been focused on patients undergoing day-case surgery. Objective: The aim of this prospective randomized study was to determine whether preoperative carbohydrate loading enhanced the recovery of patients undergoing day-case cholecystectomy. Design: A randomised controlled trial. Setting: Secondary care in a district general and a university hospital in Finland between 2013-2016. Patients: A total of 113 patients ASA physical status I or II (18-70 yr) undergoing day-case cholecystectomy were included in the study. Exclusion criteria were bleeding or coagulation disorders, BMI >40, dementia, insulin-treated diabetes, migraine, Meniere's disease or a history of alcohol or drug abuse. Intervention: The carbohydrate rich drink (CHD) group received oral carbohydrate (200 ml) 2-3 h before surgery, and the control (Fasting) group fasted from midnight according to standard protocol. Main outcome measures: Visual analogue scales (VAS) were used to score six discomfort parameters. The needs for analgesia or antiemetics, the time to drinking, eating and first mobilization after surgery, and the time to discharge and hospital readmission were recorded.

Official Title
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Effect of Preoperative Oral Carbohydrate Loading on Recovery in Patients Undergoing Day-case Cholecystectomy. A Randomised Controlled Trial.

Conditions
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Preoperative Care

Intervention / Treatment
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* Dietary Supplement: carbohydrate rich drink


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients between 18-70 yr (ASA physical status I-II) eligible for day-case cholecystectomy Exclusion Criteria: Patients with bleeding or coagulation disorders, BMI >40, dementia or suffering from insulin-treated diabetes, migraine, Meniere's disease or with history of alcohol or drug abuse

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Fasting group<br> | |
| Active Comparator: Carbohydrate rich drink (CHD) group<br> | Dietary Supplement: carbohydrate rich drink<br>* The carbohydrate rich drink (CHD) group received oral carbohydrate (200 ml) 2-3 h before surgery,<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of given pain and antiemetic medication (n) |  | One day (in recovery room after operation to discharge time) | 
| Thirst, hunger, dryness of mouth, tiredness, nausea, and pain (Visual analogue scale, VAS 0-100) |  | One day (4 hours after operation and at discharge) | 
| Time of drinking, eating and first mobilisation (minutes after operation) |  | One day (in recovery room after operation to discharge time) | 
| Time of discharge (hours after operation) |  | One day (time of discharge) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Carbohydrate loading, oral carbohydrate beverage