linjc16/ctgov huggingface dataset:
Hemodynamic and Respiratory Effects of Esophageal Dilation in Children

Study Overview
=================
Brief Summary
-----------------
The aim of this study compares hemodynamic and respiratory changes and complications in children who undergoing endoscopy for esophageal balloon dilatation and endoscopy for only control.

Detailed Description
-----------------
Esophageal strictures in children may develop as a secondary to a surgically repaired esophageal atresia (anastomatic strictures) or as a result of chemical injury after caustic ingestion. Emerging strictures are dilated with balloon catheter at regular intervals. The possibility of various complications depending on the level of the stenosis during the dilation of esophagus. During Esophageal dilation may be pressed into airways and/or vascular structure.

Official Title
-----------------
Esaphageal Balloon Dilatation in Children: Hemodynamic , Ventilatory Changes and Complications

Conditions
-----------------
Obstruction of Esophagus, Respiratory Complication, Hemodynamic Instability

Intervention / Treatment
-----------------
* Procedure: endoscopic dilatation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: endoscopy for esaphageal dilatation and control ASA I-III 0-16 year old Exclusion Criteria: ASA IV endoscopy for removing foreing body

Ages Eligible for Study
-----------------
Maximum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: dilatation<br>esaphageal dilatation group | Procedure: endoscopic dilatation<br> <br> |
| No Intervention: control<br>control group ( only endoscopy for control) | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| peak inspiratory pressure |  | at time of endoscopy(0-40minute) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| complications ( laryngospasm, bronchospasm, can not be ventilated, decreased Sp02) |  | at time of endoscopy and after the endoscopy within 2 hours | 
| Sp02 |  | at time of endoscopy and after the endoscopy within 2 hours | 
| pressure levels for target tidal volume |  | at time of endoscopy(0-40minute) | 
| mean arterial pressure-mmHg |  | at time of endoscopy(0-40minute) | 
| heart rate-per/min |  | at time of endoscopy(0-40minute) |
Retinal Function in Diabetic Patients Without Retinopathy

Study Overview
=================
Brief Summary
-----------------
The primary purpose was to assess, in diabetic patients without diabetic retinopathy and control subjects, color vision, contrast sensitivity, electroretinography, and flicker-induced vasodilatation using the Dynamic Vessel Analyzer, in order to specify the earliest impaired retinal cells in diabetes, and gain more insight into diabetic retinopathy pathogenesis.

Detailed Description
-----------------
Type 1 and type 2 diabetic patients with no diabetic retinopathy and no hypertension were compared with sex and age-matched control subjects. Color vision was tested with the desaturated LANTHONY 15-Hue test. Contrast sensitivity was assessed with the Pelli-Robson contrast sensitivity test. Pattern-electroretinogram, Ganzfeld full-field electroretinogram and multifocal electroretinogram were recorded according to the International Society for Clinical Electrophysiology of Vision (ISCEV). Flicker-induced vasodilatation in retinal arteries and veins was assessed using the Dynamic Vessel Analyzer.

Official Title
-----------------
Assessment of Retinal Functional Abnormalities in Diabetic Patients Without Retinopathy

Conditions
-----------------
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: For diabetic patients : age between 20 and 55 type 1 or type 2 diabetes mellitus diabetes duration of more than 5 years no diabetic retinopathy on fundus examination or fundus photographs For control subjects : sex and age matching with the diabetic patients no diabetes, no familial or personal history of elevated blood sugar Exclusion Criteria: *For both diabetic patients and control subjects : presence of cataract or history of cataract surgery intraocular pressure of more than 21 mmHg abnormal score on the Ishihara test other ocular disease ametropia more than 3 diopters, anisometropia more than 1 diopter, astigmatism more than 1 diopter systemic hypertension (defined as systolic blood pressure > 140 mmHg, diastolic blood pressure > 90 mmHg) treatment with vasoactive drugs tobacco consumption of more than 20 cigarettes a day

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Diabetic patients without diabetic retinopathy : No intervention | |
| 2<br>Sex and age-matched control subjects : No intervention | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Diabetic retinopathy, Color vision, Contrast sensitivity, Electroretinogram, Flicker-induced vasodilatation, Dynamic Vessel Analyzer
A Trial of Capecitabine (Xeloda), Oxaliplatin and Irinotecan in Combination With Bevacizumab in 1st Line Treatment of Metastatic Colorectal Cancer

Study Overview
=================
Brief Summary
-----------------
A Phase I-II Trial of Capecitabine (Xeloda), Oxaliplatin and Irinotecan in Combination with Bevacizumab in 1st Line Treatment of Metastatic Colorectal Cancer

Detailed Description
-----------------
A Phase I-II Trial of Capecitabine (Xeloda), Oxaliplatin and Irinotecan in Combination with Bevacizumab in 1st Line Treatment of Metastatic Colorectal Cancer

Official Title
-----------------
A Phase I-II Trial of Capecitabine (Xeloda), Oxaliplatin and Irinotecan in Combination With Bevacizumab in 1st Line Treatment of Metastatic Colorectal Cancer

Conditions
-----------------
Metastatic Colorectal Cancer

Intervention / Treatment
-----------------
* Drug: Capecitabine (Xeloda), Oxaliplatin, Irinotecan, Bevacizumab


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with diagnosed Metastatic Colorectal Cancer Exclusion Criteria: Patients with diagnosis other than Metastatic Colorectal Cancer

Ages Eligible for Study
-----------------
Minimum Age: 14 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Capecitabine (Xeloda), Oxaliplatin, Irinotecan, Bevacizumab|Capecitabine (Xeloda), Oxaliplatin, Irinotecan, Bevacizumab|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Metastatic Colorectal Cancer
Epidemiological Study of Quality of Life in Osteopathy

Study Overview
=================
Brief Summary
-----------------
Aim of this study is to evaluate the effectiveness of osteopathy in changing quality of life in a large sample of naive patients undergoing osteopathic manipulative treatment.

Conditions
-----------------
Muscle Skeletal Disorders

Intervention / Treatment
-----------------
* Other: Osteopathic Manipulative Treatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: older than 18 years old affected by muscle-skeletal disorder Exclusion Criteria: younger than 18 years old OMT undertaken during the last 12 months Any manual therapy received during the last 12 months

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: OMT<br> | Other: Osteopathic Manipulative Treatment<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change from baseline in General Health score |  | baseline and 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change from baseline in Physical Component score |  | baseline and 1 month | 
| change from baseline in Mental Component score |  | baseline and 1 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Osteopathic manipulative treatment, muscle-skeletal disorder, quality of life
The Relationship Between Voiding Dysfunction and Intravesical Sensory Threshold in Diabetes Women

Study Overview
=================
Brief Summary
-----------------
The investigators will recruit a cross-sectional group of diabetic women in internist clinics. UDS will be applied for voiding function in each case. Intravesical electrical stimulation will be used to test CPT per 5 Hz, 250 Hz, 2000 Hz for the patients. The differences of intravesical CPT between diabetic women with and without voiding dysfunction will be determined.

Detailed Description
-----------------
Diabetes is a common metabolic disease of multiorgan involvement. The American Diabetes Association reported that the prevalence of diagnosed and undiagnosed diabetes mellitus (DM) in the United States is currently 6% and rising. The increase is secondary to a rising incident in obesity, as well as a change in the criteria for the diagnosis of DM from a fasting blood glucose 140 mg/dl to 126 mg/dl. Besides impaired blood glucose regulation, many direct and indirect sequelae of DM can occur. Triopathy of diabetes including retinopathy, neuropathy, and nephropathy are familiar to every internist. Lower urinary tract dysfunction is one of the most common complications in this group of patients. We look at the difference of intravesical sensation in diabetic women by current perception test; then, we can find the patient with diabetic cystopathy in early stage. We compare the groups of diabetic women with or without voiding dysfunction by urodynamic study. CPT test for intravesical sensation will be applied.

Official Title
-----------------
A Cross-Sectional Study of the Relationship Between Voiding Dysfunction and Intravesical Sensory Threshold in Diabetes Women

Conditions
-----------------
Diabetes Mellitus

Intervention / Treatment
-----------------
* Device: intravesical current perception test


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The diabetic women followed up in specialist clinics over one year at National Taiwan University Hospital (NTUH) Exclusion Criteria: Concurrent neurological problems or other medical conditions that might interfere with voiding function Acute urinary tract infection (UTI) Previous pelvic surgery Vaginal prolapse

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: intravesical current perception test|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
diabetic cystopathy, bladder, voiding dysfunction, current perception test
0.12% Chlorhexidine Oral Care for the Prevention of Non-ventilator Hospital-acquired Pneumonia

Study Overview
=================
Brief Summary
-----------------
Chlorhexidine is a effective strategy in reducing ventilator associated pneumonia. However, it is unclear if prophylactic 0.12% chlorhexidine oral rinse can reduce the risk of non-ventilator hospital-acquired pneumonia among hospitalized patients.

Detailed Description
-----------------
Participants will be classified into three groups, applied twice a day by care givers. Oral colonization will be tested in the baseline, day-3, day-7, and at the discharge. Quantitation of colonization of the oral cavity by oral rinses and respiratory pathogens were measured.

Official Title
-----------------
Effect of 0.12% Chlorhexidine Oral Care for the Prevention of Non-ventilator Hospital-acquired Pneumonia Among Hospitalized Patients

Conditions
-----------------
Hospital-acquired Pneumonia

Intervention / Treatment
-----------------
* Drug: 0.12% Chlorhexidine Oral Liquid Product
* Drug: Listerine Oral Liquid Product
* Other: Normal Saline Product


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Hospitalized patients > 20 years old without ventilator Exclusion Criteria: known hypersensitivity to or intolerance of Chlorhexidine or Listerine

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Sequential Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 0.12% chlorhexidine<br>Participants will be randomized to Chlorhexidine solution group, applied twice a day by care givers. | Drug: 0.12% Chlorhexidine Oral Liquid Product<br>* The intervention group 1 received 10ml 0.12% chlorhexidine solution for oral rinse twice a day.<br>|
| Sham Comparator: Listerine<br>Participants will be randomized to Listerine solution group, applied twice a day by care givers. | Drug: Listerine Oral Liquid Product<br>* The intervention group 2 received 10ml Listerine solution for oral rinse twice a day.<br>|
| Placebo Comparator: Normal saline<br>Participants will be randomized to Normal saline group, applied twice a day by care givers. | Other: Normal Saline Product<br>* The control group received 10ml normal saline for oral rinse twice a day.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| oral bacterial colonization status |  | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The rate of non-ventilator associated pneumonia |  | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
0.12% chlorhexidine, Oral rinse, Hospital-acquired pneumonia
Sonographic Evaluation of Diaphragmatic Function in Critical Care Patients With Use of Non Invasive Ventilation

Study Overview
=================
Brief Summary
-----------------
Usefulness of non invasive ventilation in patients extubated after more than 48 hours of invasive ventilation is still in debate except for specific patients (chronic pulmonary disease and chronic heart failure). Many experimental and clinical studies have shown that diaphragmatic function is depressed by mechanical ventilation in intubated patients. The investigators will test the hypothesis that non invasive ventilation after extubation may improve diaphragmatic function

Official Title
-----------------
Sonographic Evaluation of Diaphragmatic Function in Critical Care Patients With Use of Non Invasive Ventilation

Conditions
-----------------
Critical Care, Invasive Mechanical Ventilation

Intervention / Treatment
-----------------
* Other: Sonographic diaphragmatic measurements


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient extubated after at least 48 hours of invasive ventilation Requiring non invasive ventilation Consent of patient Exclusion Criteria: Diaphragmatic paralysis Neuromuscular disease significant pleural effusion atelectasis requiring bronchoscopy abdominal hypertension

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Sonographic diaphragmatic measurements|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diaphragmatic excursion |  | Before the first NIV session | 
| Diaphragmatic thickening |  | Before the first NIV session | 
| Diaphragmatic excursion |  | After the first NIV session | 
| Diaphragmatic thickening |  | After the first NIV session | 
| Diaphragmatic excursion |  | After 24 h of NIV use | 
| Diaphragmatic thickening |  | After 24 h of NIV use | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Non invasive ventilation, Critical care patients, Extubation after 24 hours of invasive ventilation, Sonography, Diaphragmatic function
Young Patient With Aortic Dissection or Aneurysm: A Prospective Observational Cohort Study

Study Overview
=================
Brief Summary
-----------------
Aortic dissection or aneurysm is unusual in young patients, and frequently associated with unusual presentations. However studies about this area is scarce. Besides, the treatment option is not clare. The prognosis of this cohort is also unclear. The goal of this study was to better understand the characters, treatment option and prognosis of young patient with aortic dissection or aneurysm.

Detailed Description
-----------------
To understand the clinical characteristics, treatment options and prognosis of aortic dissection or aneurysm in young people，the study plan will include young people younger (≤50 years) with aortic dissection or aneurysm from 2020.6. Then collect their clinical data and conduct follow-up studies, in order to understand younger aortic dissection or aneurysm patients.

Official Title
-----------------
Clinical Characters, Treatment and Prognosis of the Young Patient With Aortic Dissection or Aneurysm: A Prospective Observational Cohort Study

Conditions
-----------------
Aortic Aneurysm and Dissection

Intervention / Treatment
-----------------
* Behavioral: movement


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: young patients with aortic dissection or aneurysm Exclusion Criteria: Aortic dissection or aneurysm due to traumatic

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| younger aortic dissection or aneurysm patients<br>this is an observation cohort study about younger aortic dissection or aneurysm patients without intervention. | Behavioral: movement<br>* movement<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical features of young aortic dissection and aneurysm patients | Collecting clinical data, such as basic information, blood biochemical information and imaging informatio to describe the characteristics of young people. | before December 2021 |
Bone Fragility Evaluation in Obese Patients

Study Overview
=================
Brief Summary
-----------------
This research will study the bone fragility in obese patients, on DXA and CT-scan, in a transversal study. The investigators want also to study the specific risk factors of bone fragility in these obese patients (relationship between body composition on whole body on DXA, fat mass and its location, lean mass, weight loss after surgery and SBAC-L1), to improve the bone screening.

Official Title
-----------------
Bone Fragility Evaluation by Dual X-Ray Absorptiometry (DXA) and CT-scan (Vertebral Fracture and Scanographic Bone Attenuation Coefficient of the First Lumbar Vertebra SBAC-L1) in Obese Patients

Conditions
-----------------
Obesity, Bariatric Surgery Candidate

Intervention / Treatment
-----------------
* Diagnostic Test: DXA and CT-scan


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients followed at Nancy university hospital for a bariatric surgery CT-scan and DXA performed before surgery, with maximum 1 year before the 2 exams Exclusion Criteria: < 18 years Protected adults

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Obese patients followed at Nancy University Hospital<br> | Diagnostic Test: DXA and CT-scan<br>* DXA and CT-scan are usually performed during the following of these patients before bariatric surgery<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| scanographic bone attenuation coefficient of the first lumbar vertebra SBAC-L1 | on axial section of the first lumbar vertebra, with a region of interest | November 2019-September 2020 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vertebral fracture | According Genant classification, on sagittal section of spine | November 2019-September 2020 | 
| DXA: T-score | in standard deviation, on spine / hip / femoral neck / wrist | November 2019-September 2020 | 
| DXA: Bone mineral density BMD (spine, hip , femoral neck, wrist) | in g/cm² | November 2019-September 2020 | 
| DXA: lean and fat mass | in % and reartition of each | November 2019-September 2020 |