Comparison of Pantoprazole and Ranitidine in Dyspepsia

Study Overview
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Brief Summary
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The H0 hypothesis of the study is there is no difference between pantoprazole and ranitidine in treating patients presented with dyspepsia to the emergency department. The H1 hypothesis is there is difference between pantoprazole and ranitidine in treating patients presented with dyspepsia to the emergency department.

Detailed Description
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Dyspepsia is one of the common complaints in emergency department. Proton pomp inhibitors, H2 receptor blockers and anti-acids are common drugs for treating dyspepsia in emergency department. However there is no study in the emergency department comparing the effectiveness of these drugs. So the investigators planned this study which drug is effective in these patients in order to provide a cost-effective treatment in dyspeptic patients.

Official Title
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Intravenous Pantoprazole vs Ranitidine in Dyspepsia in Emergency Department: A Randomized Controlled Trial.

Conditions
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Dyspepsia

Intervention / Treatment
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* Drug: Pantoprazole
* Drug: Ranitidine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Epigastric pain Older than 18 years old Exclusion Criteria: Diagnosed as cholecystitis, pancreatitis, myocardial infarction, etc.. at the end of the emergency deparment evaluation period. Pregnancy Patients with unstable vital signs Patients used anti-acid, H2 receptor blockers and proton pomp inhibitors in the last one hour. Allergy to H2 receptor blockers and proton pomp inhibitors. Patients denied to give inform consent and who are illiterate

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: pantoprazole<br>Intravenous pantoprazole 40 mg flacon | Drug: Pantoprazole<br>* 33 patients<br>* Other names: Pantpas;|
| Active Comparator: ranitidine<br>Intravenous ranitidine 50 mg | Drug: Ranitidine<br>* 33 patients<br>* Other names: Ulcuran;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual Analogue Scale Score | The investigators are measuring the change of pain from the baseline to the 30th and 60th minutes by visual anologue scale (VAS). Visual Analogue Scale measurement is between 0 (no pain) and 100 (worst pain). A decrease of 13 or 16 mm in VAS score is accepted as a minimum clinically significant change in pain. | 30th and 60th minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Need for Additional Drug | The investigators are measuring the need for additional drug at the end of 60 minutes. | 60 th minute | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dyspepsia, pantoprazole, ranitidine, emergency department