Multimodal Analysis of the Young Brain on Rhythm Perception: From Premature Neonates to Infants

Study Overview
=================
Brief Summary
-----------------
Premature neonates are able to discriminate phonemes and voice from 28wGA at a time the neuronal network establish contact between the environment and the cortical neurones. In the present monocentric study the investigators will analyse the response of the cortical network in premature aged between 28 and 40 wGA in response to auditory stimuli using High Resolution Electroencephalography and High Density Near Infrared Spectroscopy

Official Title
-----------------
Multimodal Analysis of the Young Brain on Rhythm Perception: From Premature Neonates to Infants

Conditions
-----------------
Time Perception, Rhythm, EEG, fNIRS, ERP, Premature Neonates, Discrimination

Intervention / Treatment
-----------------
* Other: EEG
* Other: NIRS


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Full term neonates between 28 and 40 weeks Gestational Age Exclusion Criteria: Neonates outside the age range

Ages Eligible for Study
-----------------
Minimum Age: 0 Days
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Exposition I<br>preterm neonates between 28 and 30 wGA Exposition to music during the NICU period | Other: EEG<br>* EEG recording during prematurity or around term<br>Other: NIRS<br>* NIRS recording during prematurity or around term<br>|
| Experimental: Exposition II<br>preterm neonates between 32 and 34 wGA Exposition to music during the NICU period | Other: EEG<br>* EEG recording during prematurity or around term<br>Other: NIRS<br>* NIRS recording during prematurity or around term<br>|
| Active Comparator: Control I<br>preterm neonates between 28 and 30 wGA | Other: EEG<br>* EEG recording during prematurity or around term<br>Other: NIRS<br>* NIRS recording during prematurity or around term<br>|
| Active Comparator: Control II<br>preterm neonates between 32 and 34 wGA | Other: EEG<br>* EEG recording during prematurity or around term<br>Other: NIRS<br>* NIRS recording during prematurity or around term<br>|
| Active Comparator: Control III<br>preterm neonates between 36 and 40 wGA | Other: EEG<br>* EEG recording during prematurity or around term<br>Other: NIRS<br>* NIRS recording during prematurity or around term<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Variations of the response of the cortical network using High Resolution Electroencephalography before auditory stimuli between the 5 infant groups |  | one day | 
| Variations of the response of the cortical network using High Resolution Electroencephalography during auditory stimuli between the 5 infant groups |  | one day | 
| Variations of the response of the cortical network using High Resolution Electroencephalography after auditory stimuli between the 5 infant groups |  | one day | 
| variations of the response of the cortical network using High Density Near Infrared Spectroscopy before auditory stimuli between the 5 infant groups |  | one day | 
| variations of the response of the cortical network using High Density Near Infrared Spectroscopy during auditory stimuli between the 5 infant groups |  | one day | 
| variations of the response of the cortical network using High Density Near Infrared Spectroscopy after auditory stimuli between the 5 infant groups |  | one day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Time perception, rhythm, EEG, fNIRS, ERP, Premature neonates, Discrimination