Cardiovascular and Renal Outcomes of Integrated Management of Blood Pressure and Other Cardiometabolic Risks in Hypertensives

Study Overview
=================
Brief Summary
-----------------
this clinical trial is designed to study the cardiovascular and renal outcomes of hypertensives after an integrated management of blood pressure and other cardiometabolic risks. it is a multicenter prospective cohort study.

Official Title
-----------------
Cardiovascular and Renal Outcomes of Integrated Management of Blood Pressure and Other Cardiometabolic Risks in Hypertensives：a Multicenter Prospective Cohort Study （UPDATE-cohort）

Conditions
-----------------
Cardiovascular Risk Factor, Hypertension, Renal Disease

Intervention / Treatment
-----------------
* Other: integrated management


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Outpatients from departments of Cardiology, Endocrinology, Nephrology, Neurology, Geriatrics or General Internal Medicine. Diagnosed as hypertension. Diagnostic criteria: 1)The office BP measured at the day of visit and at least one time before that day were above the cut-off values ( ≥140 mmHg SBP and/or ≥90 mmHg DBP); 2)for patients with normal BP at the day of visit, they should have already been given pre-treatment with antihypertensive drugs ≥ 2 weeks. Voluntary participation. Exclusion Criteria: Patients aged< 18 years old. Patients without a definite diagnosis of hypertension(for instance, if the patient has been taking antihypertensive drugs irregularly, it is difficult to confirm the diagnosis of hypertension). Patients with a definite diagnosis of secondary hypertension. Patients are diagnosed dyslipidemia with clear cause, such as nephrotic syndrome, severe hypothyroidism, terminal stage of malignancy, etc. Patients are diagnosed end-stage renal disease, hemodialysis, and peritoneal dialysis patients. Patients diagnosed with mental abnormalities who are unable to complete the questionnaire. Patients have once participated in this research during this study cycle(to avoid repeated participation).

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| control group without an integrated management<br> | |
| observational group with an integrated management<br> | Other: integrated management<br>* establish an integrated management on cardio-metabolic risk factors including hypertension by updating and upgrading the daily practice of practitioners and screening patients<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| complex outcome | number of participants with 3P-MACE events(cardiovascular deaths, non-fatal myocardial infarction, non-fatal stroke) | follow-up 1 year | 
| coronary angioplasty | number of participants with coronary angioplasty | follow-up 1 year | 
| acute renal failure | number of participants with acute renal failure(eGFR decreases by 50% or <15ml/min/1.73m2, dialysis or renal death) | follow-up 1 year | 
| acute heart failure | number of participants with acute heart failure(non-scheduled hospitalizations due to heart failure or required intravenous medication) | follow-up 1 year |