Postoperative Nausea and Vomiting in Laparoscopic Abdominal Surgery

Study Overview
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Brief Summary
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The goal of this clinical trial is to compare frequency with postoperative nausea and vomiting in ASA( American Society of Anesthesiologists) I, II patients undergoing laparoscopic surgery. The main question[s] it aims to answer are: Primary Outcome is the incidence of nausea and vomiting between 0-6 and 6-24 hours postoperatively and the need for additional antiemetics Secondary outcome is detection of additional analgesic needs and complications between 0-6 and 6-24 hours postoperatively. Participants will receive aprepitant or granisetron for prevention of postoperative nausea and vomiting.

Detailed Description
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The aim of this study is to investigate the effectiveness of drugs used for postoperative nausea and vomiting in laparoscopic surgeries. In the research; During the operation, the patient's vitals will be recorded intraoperative forms. Vitals are; heart rate, blood pressure, oxygen saturation, end tidal carbon dioxide levels; according to the pain level after awakening from the patient follow-up forms in the service. The doses and times of analgesics will be screened, the frequencies of postoperative nausea, retching, vomiting, and additional antiemetic doses will be screened, respiratory depression, complications of anesthesia, arrhythmia, laryngospasm, hypo-hypertension, headache, dizziness, allergic reactions anxiety symptoms will be screened too. we will try to emphasize which antiemetic is more effective than the other and which one has few side effects

Official Title
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Retrospective Comparison of the Effects of Granisetron and Aprepitant in the Prevention of Postoperative Nausea and Vomiting in Laparoscopic Abdominal Surgery

Conditions
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Postoperative Nausea, Vomiting

Intervention / Treatment
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* Drug: Aprepitant
* Drug: Granisetron


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA I, II patients patients undergoing laparoscopic surgery Exclusion Criteria: ASA III and above patients who refused to participate in the study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: group 1:patient who receive aprepitant group 2: patient who receive granisetron
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Aprepitant<br>Substance P inhibitor chemotherapeutic and also useable for prevention of postoperative nausea and vomiting | Drug: Aprepitant<br>* The drug is given 1 hour before the start of the surgery<br>* Other names: Emend;|
| Active Comparator: Granisetron<br>5- HT3( 5-hydroksitriptamine 3) antagonist drug for prevention of postoperative nausea and vomiting | Drug: Granisetron<br>* The drug is given 10 minutes before the patients's extubation<br>* Other names: Sinarex;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| incidence of nausea | the incidence of nausea between 0-6 and 6-24 hours postoperatively | postoperative 24 hours | 
| the need for additional antiemetics | the need for additional antiemetics between 0-6 and 6-24 hours postoperatively | postoperative 24 hours | 
| incidence of vomiting | the incidence of vomiting between 0-6 and 6-24 hours postoperatively | postoperative 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| additional analgesic need | Detection of additional analgesic needs between 0-6 and 6-24 hours postoperatively. | postoperative 24 hours | 
| detection of complications | detection of complications between 0-6 and 6-24 hours postoperatively. | postoperative 24 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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postoperative nausea and vomiting, laparoscopic surgery