The Learning Effects of Task-priority Strategy on Dual-task Weight Shifting and Brain Plasticity in Patients With Parkinson's Disease

Study Overview
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Brief Summary
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(1) postural and suprapostural performance of a dual task would be differently affected by the strategy of task prioritization and (2) the cortical activation is different according to attentional focus strategies.

Detailed Description
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These hypothesis would be tested by gait performance, suprapostural accuracy and relative power spectrum of EEG.

Official Title
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The Learning Effects of Task-priority Strategy on Dual-task Weight Shifting and Brain Plasticity in Patients With Parkinson's Disease

Conditions
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Postural and Suprapostural Performance During Dual Tasking in Patients With Parkinson's Disease

Intervention / Treatment
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* Behavioral: Weight-shifting training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1. modified H-Y stage II-III Parkinson's disease 2. No other diseases 3. Non-demented PD 4. Non-tremor PD Exclusion Criteria: None

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Postural<br>During training, participants in this group are instructed to focus on their posture during weight-shifting. | Behavioral: Weight-shifting training<br>* Postural task: Participants are standing with their weak side on the force plate. During the task, they wight-shift from side to side ranging from 10 to 90 percent of their body weight. Suprapostural task: Participants hold a tray with their arms beside the body, 90 degrees of elbow flexion. They rotate the tray left and right for 45 degrees respectively. During their task, participants should weight-shift and rotate the tray at the same time.<br>|
| Experimental: Suprapostural<br>During training, participants in this group are instructed to focus on their suprapostural task during weight-shifting. | Behavioral: Weight-shifting training<br>* Postural task: Participants are standing with their weak side on the force plate. During the task, they wight-shift from side to side ranging from 10 to 90 percent of their body weight. Suprapostural task: Participants hold a tray with their arms beside the body, 90 degrees of elbow flexion. They rotate the tray left and right for 45 degrees respectively. During their task, participants should weight-shift and rotate the tray at the same time.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| EEG relative power in the delta band | postural and suprapostural performance of a dual task | 60 minutes | 
| EEG relative power in the theta band | postural and suprapostural performance of a dual task | 60 minutes | 
| EEG relative power in the alpha band | postural and suprapostural performance of a dual task | 60 minutes | 
| EEG relative power in the beta band | postural and suprapostural performance of a dual task | 60 minutes | 
| EEG relative power in the gamma band | postural and suprapostural performance of a dual task | 60 minutes | 
| COP trajectory recorded from the force plate | performance of the postural task | 60 minutes | 
| Angles from inclinometer | performance of the suprapostural task | 60 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gait velocity from GAITRite | gait performance | 5 minutes | 
| Cadence from GAITRite | gait performance | 5 minutes | 
| Mean step length from GAITRite | gait performance | 5 minutes | 
| Step-to-step variability from GAITRite | gait performance | 5 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Parkinson, dual-task training, attention, electroencephalogram (EEG)