Methods of Etiological Diagnosis of Cerebral Amyloid Angiopathy

Study Overview
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Brief Summary
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The purpose of this study is to Early identify patients based on clinical manifestation, imaging, gene and histology, explore diagnostic tools get gene repertoire of Chinese Build a cerebral amyloid angiopathy (CAA) prospective cohorts, observing the disease history, and exploring prognostic factors of hemorrhage in CAA patients

Detailed Description
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We recruited consecutive patients with intracerebral hemorrhage(ICH). Clinical data and the results of laboratory tests and CT will be assessed and recorded. All the subjects will get gene tests including many genes related with Aβ and small vessel disease (Next-generation sequencing and target enrichment system) . The result of the MRI Scans including cerebral microbleeds(CMBs)、Cortical superficial siderosis（cSS）, white matter change(WMC) and enlarged perivascular spaces (EPVS) will be assessed using scales. Ocular fundus exams such as funduscopy and imaging will be used to assess multiple dot and blot hemorrhages and microaneurysms by ophthalmologist. Mini-mental state examination(MMSE) will be used to assess the cognitive function. Patients who need operation on the hematoma for the treatment will accept a brain tissue pathological exams According to this, a prospective cohort of CAA patients based on clinical manifestation, imaging, gene and histology will be built, and diagnostic tools such as gene and MRI results, etc will be explored. And we will get gene repertoire of Chinese patient with ICH. Then, the subjects will be followed up on 30-day, 3-month, 6-month, and 1-year.The patients' clinical outcome will be assessed , and the results of laboratory tests and therapy will be recorded. Prognostic factors of patients with CAA related ICH will be explored.

Official Title
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A Research of the Methods of Etiological Diagnosis of Cerebral Amyloid Angiopathy

Conditions
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Cerebral Amyloid Angiopathy, Intracerebral Hemorrhage

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ①diagnosed wiht spontaneous cerebral hemorrhage after the head CT. ② the patients and their family members agreed to participate in this study. Exclusion Criteria: ①cerebral hemorrhage caused by traumatic, cerebral infarction, tumor and arteriovenous malformation. ②patients who can not provide reliable information or are considered unsuitable for the study.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| apolipoprotein E gene polymorphism |  | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CMBs were evaluated using the Microbleed Anatomical Rating Scale (MARS) |  | baseline | 
| a composite outcome including multiple dot and blot hemorrhages and microaneurysms of the fundus |  | baseline | 
| recurrence of cerebral hemorrhage |  | 1 year |