Considerations on the Transfusion Threshold in Cardiac Surgery

Study Overview
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Brief Summary
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This is a retrospective observational study of the transfusion threshold in cardiac surgery. There is controversy in the literature regarding the transfusion threshold to be adopted, especially in a patient who has undergone cardiac surgery. Some authors suggest that the transfusion should be done in a restrictive way when a certain threshold in hemoglobin is reached, in order to avoid the risks it implies, especially infectious.This threshold is very controversial and remains to be defined (variations in the literature from 7g / dL to 9g / dL). Other authors conclude that there is no superiority of a restrictive transfusion compared to a more liberal transfusion, with regard to the morbidity or medical costs. It is therefore interesting to study, in a retrospective manner, the global and multidisciplinary management of patients who have undergone a cardiac surgery within the CHU Brugmann hospital, to analyze if they have been adequately transfused.

Official Title
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Considerations on the Transfusion Threshold in Cardiac Surgery

Conditions
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Cardiac Surgery

Intervention / Treatment
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* Procedure: Cardiac surgery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Patients having undergone cardiac surgery (other than the placement of a pacemaker or defibrillator) within the CHU Brugmann hospital between 2006 and 2015 Exclusion Criteria: N/A

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cardiac surgery<br>Patients having undergone cardiac surgery (other than the placement of a pacemaker or defibrillator) within the CHU Brugmann hospital between 2006 and 2015 | Procedure: Cardiac surgery<br>* Cardiac surgery<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hemoglobin rate | Hemoglobin rate | Baseline (just before cardiac surgery) | 
| Hemoglobin rate | Hemoglobin rate | One day after surgery (J1) | 
| Hemoglobin rate | Hemoglobin rate | Two days after surgery (J2) | 
| Hemoglobin rate | Hemoglobin rate | Five days after surgery (J5) | 
| Hematocrit rate | Hematocrit rate | Baseline (just before cardiac surgery) | 
| Hematocrit rate | Hematocrit rate | One day after surgery (J1) | 
| Hematocrit rate | Hematocrit rate | Two days after surgery (J2) | 
| Hematocrit rate | Hematocrit rate | Five days after surgery (J5) | 
| International Normalized Ratio (INR) | Coagulation indicator | Baseline (just before cardiac surgery) | 
| International Normalized Ratio (INR) | Coagulation indicator | One day after surgery (J1) | 
| International Normalized Ratio (INR) | Coagulation indicator | Two days after surgery (J2) | 
| International Normalized Ratio (INR) | Coagulation indicator | Five days after surgery (J5) | 
| Creatinin rate | Renal function indicator | Baseline (just before cardiac surgery) | 
| Creatinin rate | Renal function indicator | One day after surgery (J1) | 
| Creatinin rate | Renal function indicator | Two days after surgery (J2) | 
| Creatinin rate | Renal function indicator | Five days after surgery (J5) | 
| Total amount of blood perfusions | Total amount of blood perfusions | Five days after surgery (J5) | 
| Liquid balance | Ratio between total fluid intake (perfusion) and loss (blood and urine) | One day after surgery |