Longitudinal Changes in Characteristics of COVID-19 Survivors and Their Long-term Follow-up Study

Study Overview
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Brief Summary
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Follow-up study of Coronavirus disease 2019 (COVID-19) survivors has rarely been reported. We aimed to investigate longitudinal changes in the characteristics of COVID-19 survivors after discharge.

Detailed Description
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From December 2019, coronavirus disease 2019 (COVID-19), caused by a β-coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread across the globe. Numerous studies have been performed so far to investigate clinical characteristics, risk factors, potential treatment and pathogenesis of COVID-19. However, little information is available on the long-term prognosis and possible sequelae of COVID-19 survivors who have recovered and been discharged from hospital. Hence, the investigators conducted a prospective study to investigate the long-time prognosis and the possible sequelae of COVID-19 survivors. The investigators evaluated Demographic and clinical characteristics, laboratory and radiological findings,pulmonary function tests, electrocardiogram, complications as well as treatment and symptoms and signs of COVID-19 patients.

Official Title
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Longitudinal Changes in Characteristics of COVID-19 Survivors and Their Long-term Follow-up Study

Conditions
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Prognosis, Sequelae

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with confirmed COVID-19 who have complete hospitalization data. Exclusion Criteria: Suspected cases of COVID-19.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| symptoms and signs | symptoms and signs will be collected. | 1-3years | 
| Quality of Life | Quality of Life will be assesed using the MOS item short from health survey（SF-36.Minimum value:0, Maximum value: 100. Higher scores mean a better outcome. | 1-3years | 
| Mental quality | Mental quality will be assessed using hospital anxiety and depression scale.Minimum value:0, Maximum value: 21. Higher scores mean a worse outcome. | 1-3years | 
| laboratory findings,change from baseline for blood laboratory measures | the change from baseline for laboratory examination （Hb in g/L, Leukocyte in /L, neutrophil count in /L，lymphocyte count in /L，Platelet count in /L，Creatinine in μmol/L, Bilirubin in mg/dL, ALP in U/L, γ-glutamyl transpeptidase in U/L，AST in U/L, ALT in U/L, Albumin in g/dL, triglycerides in mmol/L, total cholesterol in mmol/L，cardiac troponin I in ng/mL， myoglobin in ng/mL， brain natriuretic peptide precursors in pg/mL， lactate dehydrogenase in U/L, Creatine Kinase in U/L). | 1-3years | 
| Radiological findings | Radiological findings such as chest computed tomography will be assessed. | 1-3years | 
| pulmonary function | pulmonary function tests will be assessed. | 1-3years | 
| Heart function | electrocardiogram including arrhythmia,ST-T change and conduction block will be assessed. | 1-3years | 
| Abdominal ultrasound | Abdominal ultrasound will be assessed. | 1-3years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COVID-19, follow-up, consequences