Effects of OCTA-guided PDT in Acute CSC

Study Overview
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Brief Summary
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OCTA-guided PDT is as safe and effective as ICGA-guided PDT in the treatment of acute central serous chorioretinopathy. Or OCTA-guided PDT is more effective than ICGA-guided PDT in the treatment of acute central serous chorioretinopathy, safe as well.

Official Title
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Effects of Optical Coherence Tomography Angiography-guided Photodynamic Therapy in Acute Central Serous Chorioretinopathy

Conditions
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Central Serous Chorioretinopathy, Tomography, Optical Coherence

Intervention / Treatment
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* Procedure: OCTA-guided Photodynamic therapy
* Procedure: ICGA-guided Photodynamic therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Idiopathic detachment of the neurosensory retina with a focal leak at the level of the RPE with FA Presence of SRF and/or serous pigment epithelial detachment on OCT Presence of abnormal dilated choroidal vasculature in ICGA Exclusion Criteria: Patients with other ocular conditions commonly associated with SRF, such as choroidal neovascularization, polypoidal choroidal vasculopathy (PCV), diabetic retinopathy, retinal vascular occlusion, Coat's disease Any disease that may affect the quality of imaging (quality of OCTA images < 6), such as cataract, high myopia or nystagmus History of ocular surgeries including retinal laser Pregnancy Any uncontrolled systemic disease Any condition rendering patients intolerable to image acquisition

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: OCTA group<br>Patients in this group underwent OCTA-guided half-dose photodynamic therapy. | Procedure: OCTA-guided Photodynamic therapy<br>* Half-dose photodynamic therapy using verteporfin under the guidance of OCTA<br>|
| Active Comparator: ICGA group<br>Patients in this group underwent normal ICGA-guided half dose photodynamic therapy. | Procedure: ICGA-guided Photodynamic therapy<br>* Half-dose photodynamic therapy using verteporfin under the guidance of ICGA<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with subretinal fluid resolution on OCT after PDT of two groups |  | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with leakage point resolution on FFA after PDT of two groups |  | 3 months | 
| Number of recurrent CSC after PDT of two groups |  | 3 months | 
| BCVA (best corrected visual acuity) at every follow-up of two groups |  | 1 month, 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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optical coherence tomography angiography, central serous chorioretinopathy, photodynamic therapy