Prospective Study on the Risks of Dengue Fever for the Fetus.

Study Overview
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Brief Summary
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Dengue is the most common arbovirus worldwide (390 million people infected each year) and belongs to the Flavivirus genus of the Flaviviridae family like Zika. Its expansion has been rapid since the last decade with an increase in the number of cases of 400% and the first cases of indigenous dengue described in Europe. Current data on the consequences of dengue fever on the fetus are incomplete. The risk of maternal-fetal transmission of dengue during the peripartum period has now been recorded in numerous case reports and a few case series for patients who contracted dengue in the 12 days preceding childbirth or at the time of delivery. However, the transmission of dengue is highly variable depending on the studies ranging from 1.6 to 15% and the consequences for the newborn are very variable ranging from simple thrombocytopenia to death in severe neonatal dengue. Regarding the risk of malformation, a few old cases of heart disease, hydrocephalus and neural tube closure abnormalities have been described in the literature following exposure to dengue fever during pregnancy. Since no malformative case has been described, however, to our knowledge, no prospective study with specialized ultrasound monitoring has been performed for pregnant women who contracted dengue during their pregnancy.

Official Title
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Prospective Study on the Risks of Dengue Fever for the Fetus.

Conditions
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Dengue Fever

Intervention / Treatment
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* Other: data collection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Pregnant patients Major Affiliated with social security Symptomatic or pauci-symptomatic dengue Biological confirmation of dengue fever by dengue positive PCR or IgM positive during the current dengue episode Exclusion Criteria: Multiple pregnancy Patient's refusal Protected persons: person deprived of liberty by judicial or administrative decision, minor, and person subject to a legal protection measure: guardianship or curators)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients who contracted dengue fever before 34 weeks of amenorrhea<br>Patients who contracted biologically proven dengue fever during pregnancy before 34 weeks outside the peri-partum period (more than 12 days before childbirth) | Other: data collection<br>* Ultrasound follow-up maternal dengue serology PCR (Polymerase Chain Reaction) and dengue serology of the umbilical cord<br>|
| Patients who contracted dengue fever after 34 weeks of amenorrhea<br>Patients who contracted biologically proven dengue fever during pregnancy after 34 weeks outside the peri-partum period (more than 12 days before childbirth) | Other: data collection<br>* Ultrasound follow-up maternal dengue serology PCR (Polymerase Chain Reaction) and dengue serology of the umbilical cord<br>|
| Patients who have contracted dengue during the peripartum period<br>Patients who have contracted dengue during the peripartum period or who have a suspicion of dengue (in the 12 days preceding childbirth) | Other: data collection<br>* Ultrasound follow-up maternal dengue serology PCR (Polymerase Chain Reaction) and dengue serology of the umbilical cord<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Study the teratogenic effects of the dengue virus on the fetus | Rate of fetal anomalies such as infectious fetal disease or any other fetal anomaly detected during specialized antenatal ultrasound follow-up. | at childbirth | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Study the maternal-fetal transmission of dengue fever during pregnancy | Amniotic fluid positive dengue PCR (Polymerase Chain Reaction) rate | at childbirth | 
| Study the maternal-fetal transmission of dengue fever in the peri-partum | Umbilical cord dengue positive and / or IgM (immunoglobulin M) positive PCR rate | at childbirth | 
| Study the materno-placental transmission of dengue fever during pregnancy and peri-partum | Placental dengue positive PCR rate | at childbirth | 
| Study the consequences at the placental level of dengue, in terms of anatomopathological alterations | Placental pathology abnormalities rate | at childbirth | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dengue fever ; pregnancy