Global collaboRAtion on CIC-DUX4, BCOR-CCN3, High-grade Undifferentiated Round Cell Sarcoma (URCS) Project

Study Overview
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Brief Summary
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Experimental study with biological material : case series review of clinical and histological data

Detailed Description
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This is a multicenter retrospective and prospective study that will analyze all cases with a diagnosis of Undifferentiated round cell sarcomas from 01 January 1983 and all new cases referring to each participant site.

Official Title
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Global collaboRAtion on CIC-DUX4, BCOR-CCN3, High-grade Undifferentiated Round Cell Sarcoma (URCS) Project

Conditions
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Undifferentiated Round Cell Sarcoma

Intervention / Treatment
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* Other: data collection and analysis on Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissue


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with undifferentiated round cell sarcomas treated from 01 January 1983 and all new patients will be included. Clinical and outcome information available. Histological slides/formalin-fixed paraffin-embedded tissue tumor blocks from archive available to perform the histology analysis/frozen tissue representative of the tumor available. Exclusion Criteria: Diagnosis different from undifferentiated round cell sarcomas Patient with no clinical or outcome information available
Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| retrospective cohort<br>Patients with undifferentiated round cell sarcomas treated from 01 January 1983 to April 2019 will be included. For retrospective analysis, it is expected to include about 200 patients. | Other: data collection and analysis on Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissue<br>* Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissue of cases negative for all Ewing's sarcoma molecular fusions, will be analyzed for the presence of CIC-DUX4 / BCOR-CCNB3 translocations fusion at each Institution. Treatment, outcome, and prognostic factors will be related with the molecular re-classification.<br>|
| prospective cohort<br>prospective patients with undifferentiated round cell sarcomas will be included in the study. For prospective study, it is expect to include 60 patients. | Other: data collection and analysis on Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissue<br>* Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissue of cases negative for all Ewing's sarcoma molecular fusions, will be analyzed for the presence of CIC-DUX4 / BCOR-CCNB3 translocations fusion at each Institution. Treatment, outcome, and prognostic factors will be related with the molecular re-classification.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| event free survival | Correlate clinical and pathological variables with event-free survival and overall-survival in undifferentiated round cell sarcomas. | baseline |