Estrogen and the Outer Eye in Women During Fertility Treatment

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine the relation between estrogen and progesterone levels, and between dryness of the eyes, in women during their fertile years.

Detailed Description
-----------------
Women during their fertility treatments will be submitted to the research. The research will include 3 meetings with a doctor from the ophthalmology department. Each meeting will be individual for each participant of the research. The meetings will take place during the day of regular appointment of the participant to the fertility clinic. Meeting #1: During first visit to the fertility clinic for the stimulation process. During this day will be done: 1.Submission of the patient to the research and signing on letter of agreement 2.Blood tests for estrogen, progesterone, luteinizing hormone (LH) 3.Eye examination: 3a. Filling of Schein Questionnaire 3b. Examination of the external eye: 1.microscope, 2.Schirmer test (paper strips inserted into the eye for several minutes to measure the production of tears), 3. tear break up time test (checking the eye with the fluorescein light after painting the eye with fluorescein dye) 3c. Checking the Intra Ocular Pressure with Tonometer Meeting #2: During visit to the fertility clinic for the egg collection (about 10 days after meeting #1) During this day will be done: 1.Blood tests for estrogen, progesterone, luteinizing hormone (LH) 2.Eye examination: 2a. Filling of Schein Questionnaire 2b. Examination of the external eye: 1.microscope, 2.Schirmer test (paper strips inserted into the eye for several minutes to measure the production of tears), 3. tear break up time test (checking the eye with the fluorescein light after painting the eye with fluorescein dye) 2c. Checking the Intra Ocular Pressure with Tonometer Meeting #3: During visit to the fertility clinic for the pregnancy test (about 14 days after meeting #2) During this day will be done: Blood tests for estrogen, progesterone, luteinizing hormone (LH) Eye examination: 2a. Filling of Schein Questionnaire 2b. Examination of the external eye: 1.microscope, 2.Schirmer test (paper strips inserted into the eye for several minutes to measure the production of tears), 3. tear break up time test (checking the eye with the fluorescein light after painting the eye with fluorescein dye) 2c. Checking the Intra Ocular Pressure with Tonometer Collection and summary of all the data End of the research

Official Title
-----------------
The Influence of the Hormonal Fertility Treatment of Women, on the Eye Surface and the Eye Dryness

Conditions
-----------------
Dry Eye Syndromes

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: women during fertility treatment without any known eye diseases no current or past history of treatment against dry eye Exclusion Criteria: known eye disease current or past history of treatment against dry eye

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 37 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| women during fertility treatment<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evidence of clinically definite dry eye confirmed by Schirmer test and tear break up time test |  | 24 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evidence of clinically definite dry eye confirmed by Schirmer test and tear break up time test during each on of the meetings #1,#2 (day 0, day 10) |  | 0 days, 10 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
dry eye, fertility treatment, Meibomian gland dysfunction, supra physiologic estrogen level