MRI Study of Saccadic Adaptation

Study Overview
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Brief Summary
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Accurate execution of our directed behaviors in the immediate environment allows the vast majority of our daily activities. Through the movements of our eyes and different parts of our body, we perceive, explore and act on our environment and can exchange and communicate with others. The mechanisms of sensorimotor adaptation of saccades (saccadic adaptation) contribute on the one hand to maintain the accuracy of saccades in the short, medium and long term, by opposing the deleterious effects of various physiological changes (development, aging), pathological or environmental (optical corrections). The aim of this study is to identify neuronal structures and networks involved in saccadic adaptation through the study of brain metabolic activation (BOLD) during the development of the adaptation of reactive saccades. The study will be organized in a single session with 3 runs. Each run include 4 blocks: 3 include the double-step target paradigm RND, U+, U-) and one without target jump (STA). The 'U+'/ 'U-'blocks include saccadic trials with forward/backward displacement of the target during a targeting saccade, the 'RND' block include saccadic trials with random target jump (forward or backward) and the 'STA' block are trials without displacement of the target. Each subject will make 12 repetitions of the 4 blocks.

Official Title
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Coupling Between Saccadic Adaptation and Visuospatial Perception Process: MRI Study in Humans

Conditions
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Healthy Volunteers

Intervention / Treatment
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* Behavioral: fMRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Age: 18 to 40 years included, Exclusion Criteria: Known ophthalmological or neurological pathology, Non-stabilized medical condition, Taking psychotropic treatment, No fluency in reading in French, Pregnant and / or breastfeeding woman

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Measurement of the bold signal<br> | Behavioral: fMRI<br>* saccadic adaptation (target presentations, with or without target jump) during fMRI exam<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| BOLD signal | cerebral activations with fMRI measures when the subject fixates or shifts gaze toward visual targets (behavioral tasks). | throughout the behavioral experiment at Day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Eye movements | measurement of the eye movements (saccades) of the subject while fixating and shifting gaze toward visual targets (behavioral tasks). | during the development of saccadic adaptation (throughout the behavioral experiments at Day 1) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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saccadic adaptation, visual-spatial perception, fMRI