The Effect of CPAP on Lung Hyperinflation in Patients With OSA

Study Overview
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Brief Summary
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Assessment of the lung hyperinflation by bodypletysmography in patients with obstructive sleep apnoea treated with continuous positive airway pressure therapy.

Detailed Description
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Rationale: Obstructive sleep apnoea (OSA) is characterized by repetitive closure of upper airways leading to apnoea (complete airflow cessation) or hypopnoea (airflow limitation > 50% + blood oxygen desaturation > 3% or airflow limitation > 30% blood oxygen desaturation > 4%). The prevalence of lung hyperinflations in sleep apnoea patients and effect of continuous positive airway pressure (CPAP) therapy is not known. Process: Subjects included in the study will be obstructive sleep apnoea (OSA) patients diagnosed by respiratory polysomnography performed in the Sleep Laboratory, Department of Respiratory Medicine, University Hospital Olomouc. Bodypletysmography will be performed in the time of OSA diagnosis and after 3 months of CPAP therapy. Data will be statistically evaluated after completion of the target number of subjects.

Official Title
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The Effect of Continuous Positive Airway Pressure Therapy on Lung Hyperinflation in Patients With Obstructive Sleep Apnoea

Conditions
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Obstructive Sleep Apnea

Intervention / Treatment
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* Device: Continuous Positive Airway Pressure therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Obstructive sleep apnoea syndrome indicated for CPAP therapy (Apnoea- Hypopnoea index ˃ 15) Exclusion Criteria: - Bilevel positive airway pressure therapy Total lung capacity < 80% lower limit of normal values Obstructive ventilatory disorder Change in body weight ˃ 10% Change in smoking status

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Continuous Positive Airway Pressure<br>Patient treated with continuous positive airway pressure | Device: Continuous Positive Airway Pressure therapy<br>* Standard treatment with continuous positive airway pressure<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of Vital Capacity (VC) (ml) | Percentage change of Vital Capacity after 3 months of CPAP therapy. | 3 months | 
| Change of Forced Expiratory Volume in 1 second (FEV1) (ml) | Percentage change of Forced Expiratory Volume in 1 second after 3 months of CPAP therapy. | 3 months | 
| Change of Total Lung Capacity (TLC) (ml) | Percentage change of Total Lung Capacity after 3 months of CPAP therapy. | 3 months | 
| Change of Residual Volume (RV) (ml) | Percentage change of Residual Volume after 3 months of CPAP therapy. | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Obstructive Sleep Apnea, Continuous Positive Airway Pressure, Lung hyperinflation