Inhalation Intervention for Nausea in the Emergency Department

Study Overview
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Brief Summary
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Randomized controlled trial comparing inhalation of isopropyl alcohol vs placebo (normal saline) pads to treat nausea in emergency department patients.

Detailed Description
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This study is to investigate if inhaling the scent of a typical medical alcohol prep pad will alleviate nausea as compared to a identically packaged normal saline prep pad for the Emergency Department patient with nausea. The study length will be 10 minutes long. The subjects will take several deep nasal inhalations at the 0, 2, 5 minute marks. Level of nausea will be recorded during these times and at 10 minutes. The investigators will also assess satisfaction of the intervention. As in previous post operative unit studies,the hypothesis is that there will a significant difference in levels of nausea between the alcohol pad group versus the normal saline pad group.

Official Title
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Inhalation Intervention for Nausea in the Emergency Department

Conditions
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Nausea, Vomiting

Intervention / Treatment
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* Other: Alcohol prep pad group
* Other: Normal Saline prep pad


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age range of 18-65 years of age complaint of nausea and or vomiting ability to breathe through nose ability to read and write English Exclusion Criteria: allergy to isopropyl alcohol pregnancy or pregnancy status unknown to subject. Pregnancy test only if part of clinical course. recent upper respiratory infection recent intake of cefoperazone, disulfiram, or metronidazole or any other medications that are known produce nausea when exposed to alcohol. use of antiemetic or psychoactive drug within 24 hours alcohol abuse nicotine within last 4 hrs

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Alcohol prep pad group<br>isopropyl alcohol prep pad | Other: Alcohol prep pad group<br>* Subjects inhale scent of alcohol pad<br>|
| Placebo Comparator: Normal Saline prep pad<br>normal saline prep pad | Other: Normal Saline prep pad<br>* Subjects inhale scent of placebo (normal saline) pads<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nausea Verbal Numerical Rating Scale (0-10) at 10 Minutes Post Intervention | Primary outcome is nausea and vomiting measured on a scale from 0 (no nausea) to 10 (worst nausea imaginable) Verbal Numerical Response Scale (VNRS) at 10 minutes post intervention. | 10 minutes post intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Verbal Numerical Rating Scale Pain Score (0-10) at 10 Minutes Post Intervention | Scale ranges from 0 (no pain) to 10 (worst pain imaginable) | 10 minutes post intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Nausea, Vomiting, Antiemetic