Gender in Face-Voice Integration

Study Overview
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Brief Summary
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Bayesian models of perception represent a promising approach to describe information processing by the brain. Predictive coding hypothesizes a process in which top-down expectations are continuously compared across multiple hierarchical levels with bottom-up sensory inputs and the differences or error signals are propagated in a bottom-up direction. The investigators hypothesize that strong expectations, are best investigated in expert processes such as face and voice recognition in humans. Individuals in complex social systems need to extract socially relevant information in a fast and efficient manner; hence, the majority of humans constitute face, voice and gender experts. Nevertheless, linking such combined abilities to brain activity with regards to the predictive coding hypothesis has not been attempted.Our results suggest asymmetric contributions of visual and auditory signals to the gender classification task. This sensitive psychophysical procedure is implemented in a decoding approach using fMRI and multi-voxel pattern analysis (MVPA). The investigators plan to test whether cortical areas implicated in processing auditory and visual gender signals show similar asymmetries.

Official Title
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Neural Correlates of Multimodal Face/Voice Processing in a Gender Task.

Conditions
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Healthy

Intervention / Treatment
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* Other: fMRI study


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy men and women, right-handed No neurological antecedent Signed informed consent Exclusion Criteria: Pregnant women Volunteers with MRI contraindications: persons using a pacemaker or insulin pump, persons with a metallic prosthesis or an intracerebral clip, as well as claustrophobic subjects, neurosensory stimulator or implantable defibrillator, cochlear implants, body Foreign ferromagnetic ocular or cerebral close to nerve structures, agitation of the subject (non-cooperating or agitated subjects), ventriculoperitoneal neurosurgical bypass valves, dental apparatus. Persons under guardianship, curatorship or any other administrative or judicial measure of deprivation of rights or liberty, as well as persons of legal age protected by law. Participants refusing to be informed of the results of the medical examination (inclusion). Participants refusing to be informed of the possible detection of an anomaly.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: fMRI study<br> | Other: fMRI study<br>* Functional brain activations of face-voice processing during a gender task<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Identify neural correlates (fMRI) of face / voice interaction in a gender classification task | Classical functional analyses (GLM) and advanced statistical analyses of brain activations (BrainVoyager and Matlab softwares). | Maximum 90 days between inclusion of the subject and the 1st fMRI session (1h1 / 2). Then maximum 90 days before the 2nd session (1h1 / 2). | 
| Identify neural correlates (fMRI) of face / voice respective contribution in a gender classification task | Classical functional analyses (GLM) and advanced statistical analyses of brain activations | Maximum 90 days between inclusion of the subject and the 1st fMRI session (1h1 / 2). Then maximum 90 days before the 2nd session (1h1 / 2). | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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fMRI, perception, face-voice processing