Effect of Caffeine on Myocardial Oxygenation

Study Overview
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Brief Summary
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The purpose of this study is to investigate the impact of caffeine on myocardial oxygenation and other cardiovascular magnetic resonance parameters in healthy controls.

Detailed Description
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Caffeine is presumed to create a confounder with diagnostic imaging. The vasodilatory capacity is considered a key measure for the detection of significant coronary disease with stenosed epicardial arterial conduit vessels and overall microvascular function, including endothelial dysfunction. Twenty nine healthy controls will undergo a baseline cardiovascular magnetic resonance (CMR) exam. Afterwards, participants will consume coffee in the presence of study personnel. This will consist of 3 espresso shots, which will be consumed within 15 minutes. Approximately 2h after coffee consumption the CMR exam will be repeated. The goal will be to investigate the impact of caffeine on myocardial features. In particular the effect on the myocardial oxygenation response to vasodilating and vasoconstricting stimuli.

Official Title
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Effect of Caffeine on Myocardial Oxygenation

Conditions
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Caffeine

Intervention / Treatment
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* Other: Caffeine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Ability to give informed consent, documented by signature Aged 18 to 45 Exclusion Criteria: MRI Contraindications following current institutional guidelines at the time of the CMR exam Knowledge or suspicion of pregnancy (verified with a pregnancy test). Consumption of caffeine 12h prior to the baseline CMR exam (outside of the study protocol). Known cardiovascular disease, diabetes, severe respiratory disease, obstructive sleep apnea syndrome, chemotherapy and radiation treatment, cerebrovascular and occlusive peripheral vascular disease.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Interventional Model Description: Controlled before-after comparison
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Control<br>Control population who will undergo two cardiovascular magnetic resonance exams: one at rest and one after drinking caffeine. | Other: Caffeine<br>* Consumption of 3 shots of espresso<br>* Other names: Coffee;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in myocardial oxygenation responses | Percent (%) Measure of oxygenation-sensitive signal change measured by CMR | Through study completion up to 5 hours, before and after caffeine | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in ejection fraction | Percent (%), measured by CMR | Through study completion up to 5 hours, before and after caffeine | 
| Difference in cardiac index | L/min/m2, measured by CMR | Through study completion up to 5 hours, before and after caffeine | 
| Difference in myocardial peak strain | Percent (%), a measure of systolic function (shortening and thickening) of the myocardium measured by CMR | Through study completion up to 5 hours, before and after caffeine | 
| Difference in myocardial time to peak strain | Milliseconds (ms), measured by CMR | Through study completion up to 5 hours, before and after caffeine | 
| Difference in myocardial strain rate | Change in strain over time (/second), measured by CMR | Through study completion up to 5 hours, before and after caffeine | 
| Difference in myocardial parametric mapping | Milliseconds (ms), measured by CMR | Through study completion up to 5 hours, before and after caffeine | 
| Difference in 4D blood flow | Percent, measured by CMR | Through study completion up to 5 hours, before and after caffeine | 
| Difference in rate pressure product | Blood pressure * heart rate | Through study completion up to 5 hours, before and after caffeine | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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CMR, Myocardial oxygenation, Myocardial Function, Coffee