Pemetrexed Disodium in Treating Young Patients With Recurrent Solid Tumors

Study Overview
=================
Brief Summary
-----------------
RATIONALE: Drugs used in chemotherapy, such as pemetrexed disodium, use different ways to stop tumor cells from dividing so they stop growing or die. Pemetrexed disodium may stop the growth of tumor cells by blocking the enzymes necessary for their growth. PURPOSE: This phase I trial is studying the side effects and best dose of pemetrexed disodium in treating young patients with recurrent solid tumors.

Detailed Description
-----------------
OBJECTIVES: Primary Determine the maximum tolerated dose of pemetrexed disodium in children and adolescents with refractory solid tumors. Determine the dose-limiting toxic effects of this drug in these patients. Determine the pharmacokinetics of this drug in these patients. Secondary Determine, preliminarily, the antitumor activity of this drug in these patients. Correlate the presence of the C677T polymorphism of the methylenetetrahydrolate reductase gene, the presence of a polymorphism in the enhancer region of the thymidylate synthase (TS) gene promoter (2R and 3R tandem repeats), the presence of a polymorphism within one of those repeats, and the presence of a functional polymorphism in the 3'-untranslated region with toxicity in patients treated with this drug. Correlate homocysteine and methylmalonic acid levels at study entry with toxicity in patients treated with this drug. Correlate various gene expression profiles with response in patients treated with this drug. OUTLINE: This is a dose-escalation study. Patients receive pemetrexed disodium IV over 10 minutes on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients receive escalating doses of pemetrexed disodium until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. PROJECTED ACCRUAL: A total of 3-36 patients will be accrued for this study within 1 year.

Official Title
-----------------
A Phase I Study of Pemetrexed (LY231514, Alimta) in Children and Adolescents With Recurrent Solid Tumors

Conditions
-----------------
Unspecified Childhood Solid Tumor, Protocol Specific

Intervention / Treatment
-----------------
* Drug: pemetrexed disodium


Participation Criteria
=================
Eligibility Criteria
-----------------
DISEASE CHARACTERISTICS: Histologically confirmed solid tumor for which there is no known curative therapy or therapy that is known to prolong survival with acceptable quality of life Histologic requirement waived for intrinsic brain stem tumors No pleural effusion or ascites Neurological deficits from CNS tumors must have been relatively stable for at least 1 week prior to study entry PATIENT CHARACTERISTICS: Age 1 to 21 Performance status Karnofsky 50-100% (over 10 years of age) Lansky 50-100% (10 years of age and under) Life expectancy At least 8 weeks Hematopoietic Absolute neutrophil count at least 1,000/mm^3 Platelet count at least 100,000/mm^3 (transfusion independent) Hemoglobin at least 8.0 g/dL (transfusion allowed) Hepatic Bilirubin no greater than 1.5 times upper limit of normal (ULN) ALT no greater than 2.5 times ULN Albumin at least 2 g/dL Renal Creatinine clearance or radioisotope glomerular filtration rate at least 70 mL/min OR Creatinine based on age as follows: No greater than 0.8 mg/dL (age 5 and under) No greater than 1.0 mg/dL (age 6 to 10) No greater than 1.2 mg/dL (age 11 to 15) No greater than 1.5 mg/dL (age 16 and over) Pulmonary No evidence of dyspnea at rest No exercise intolerance Other Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception No evidence of Approved-not yet active graft-versus-host disease No uncontrolled infection Seizure disorder allowed provided it is well-controlled with anticonvulsants CNS toxicity no greater than grade 1 PRIOR CONCURRENT THERAPY: Biologic therapy Recovered from prior immunotherapy At least 7 days since prior antineoplastic biologic therapy At least 6 months since prior allogeneic stem cell transplantation More than 1 week since prior growth factors No concurrent biologic therapy No concurrent immunotherapy No concurrent prophylactic growth factor support during course 1 Chemotherapy No prior pemetrexed disodium More than 3 weeks since prior myelosuppressive chemotherapy (4 weeks for nitrosoureas) and recovered No other concurrent chemotherapy Endocrine therapy Concurrent dexamethasone for CNS tumors allowed provided dose has been stable or decreasing for at least 1 week prior to study entry Radiotherapy Recovered from all prior radiotherapy At least 2 weeks since prior local palliative radiotherapy At least 6 months since prior craniospinal radiotherapy At least 6 months since prior radiotherapy to 50% or more of the pelvis At least 6 weeks since prior substantial bone marrow radiotherapy No concurrent radiotherapy Surgery Not specified Other No trimethoprim or sulfa within 2 days before and after study drug administration No concurrent nonsteroidal anti-inflammatory agents (e.g., ibuprofen and aspirin) No other concurrent anticancer or investigational agents

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: pemetrexed disodium|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Event Free Survival |  | Length of study | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dose Limiting Toxicity | Any patient who experiences DLT at any time during protocol therapy will be considered evaluable for toxicity. Patients not experiencing DLT must complete a full cycle of therapy to be considered potentially evaluable for toxicity. Patients who are not evaluable for toxicity will be replaced. | Length of study | 
| Maximum Tolerated Dose | The MTD will be that dose at which fewer than one-third of patients experience DLT | Length of study | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
unspecified childhood solid tumor, protocol specific