Intravenous Cannulation In Children During Sevoflurane Induction

Study Overview
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Brief Summary
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This interventional simple-blind,randomized trial has included 90 children of American Society of Anesthesiologist (ASA) physical status I or II aged between 1 to 12 years of either sex, scheduled for for outpatient minor surgery under general anesthesia. This study examined whether one should make iv attempts during the early induction period (at 60 seconds) or lately (90 or 120 s) and waiting until the child receives additional sevoflurane inhalation anesthesia.

Detailed Description
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We conducted a prospective randomized study, after obtaining Institutional review board approval, which didn't require written parental consent. Children age 1-12 years, undergoing elective general anesthesia via an inhalation induction were randomized to one of three groups of 30 patients each one, for iv placement, either 60s (group E), 90 or 120 s (group L) following loss of lid reflex. Movement on iv placement and incidence of laryngospasm were determined. Difficulty with iv placement was also recorded. Statistical analysis included contingency testing, ANOVA, and non parametric testing. A P-value <0.05 was considered significant.

Official Title
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Intravenous Cannulation In Children During Sevoflurane Induction: Which Time is Adequate

Conditions
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Catheterization

Intervention / Treatment
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* Other: Difficulty of catheterization in group 60 s
* Other: Difficulty of catheterization in group 90 s
* Other: Difficulty of catheterization in group 120 s


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: children with American Society of Anesthesiologist (ASA) physical status I or II age between 1 and 12 years of either sex, were scheduled for outpatient minor surgery under general anesthesia Exclusion Criteria: age <1 and >12 years patients with full stomach a history of gastric reflux history of convulsions, cardiovascular or neuromuscular disease suspected difficult airway and hyper-reactive airway disease

Ages Eligible for Study
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Minimum Age: 1 Year
Maximum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: randomized and crossover assignemnt
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: 60s (group E)<br>The Time of catheterization at 60s (group E) was applied in this study group,after sevoflurane inhalation induction, 30 children have a catheterization after a time of 60 seconds following the eye closure and the loss of lid reflex.Difficulty with intravenous catheterization, limb movement and laryngospasm were recorded.Difficulty of catheterization in group 60 s | Other: Difficulty of catheterization in group 60 s<br> <br> |
| Other: 90s (groupe L)<br>In this study group,after sevoflurane inhalation induction, 30 children have a catheterization after a time of 90 seconds following the eye closure and the loss of lid reflex.Difficulty with intravenous catheterization, limb movement and laryngospasm were recorded.Difficulty of catheterization in group 90 s | Other: Difficulty of catheterization in group 90 s<br> <br> |
| Other: 120s (groupe L)<br>In this study group,after sevoflurane inhalation induction, 30 children have a catheterization after a time of 120 seconds following the eye closure and the loss of lid reflex.Difficulty with intravenous catheterization, limb movement and laryngospasm were recorded.Difficulty of catheterization in group 120 s | Other: Difficulty of catheterization in group 120 s<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Success of intravenous insertion | success insertion of intravenous cannula was achieved at the first attempt less than 30 seconds | from the end of study period of time after the loss of eyelash reflex to successful cannulation less than 30 seconds | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| limb movement | The movement was classified using the scale: (0 No movement, 1 movement) The incidence of laryngospasm was defined as the sudden complete or partial loss of air exchange with concurrent loss of a capnographic wave. The movement was classified using the scale: (0 No movement, 1 movement) The incidence of laryngospasm was defined as the sudden complete or partial loss of air exchange with concurrent loss of a capnographic wave. • The movement was classified using the scale: (0 No movement, 1 movement) • The movement was classified using the scale: (0 No movement, 1 movement) The limb movement was classified using the scale:0 No movement, 1 movement) | from the end of study period of time after the loss of eyelash reflex to successful cannulation less than 30 seconds | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Sevoflurane, Catheterization, Anesthetics Inhalation, child