Impact of Diet and Exercise Activity on Pregnancy Outcomes

Study Overview
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Brief Summary
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The general goal of the present study is to assess the impact of a community-based exercise and dietary intervention in pregnant women living in urban areas during and after their pregnancy on the reduction of the risks of both diabetes and obesity in mothers and their offspring. We hypothesize that a community-based lifestyle intervention program during and after gestation may improve pregnancy outcomes in terms of reducing the risk of developing obesity or type 2 DM in mothers and their children.

Detailed Description
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Impact of lifestyle intervention on excessive gestational weight gain

Official Title
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Impact of a Community-based Obesity and Diabetes Prevention Program on Pregnant Outcomes in Pregnant Women

Conditions
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Obesity, Gestational Diabetes, Type 2 Diabetes

Intervention / Treatment
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* Behavioral: Exercise and dietary education


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Pregnancy < 20 weeks. Expressed interest in study and willingness to consent to participate in the study. Exclusion Criteria: Obstetric or medical contraindications for exercise according to 2002 SOCG guideline (ruptured membranes, preterm labor, incompetent cervix, hypertensive disorders of pregnancy, growth restricted fetus, placenta previa, persistent bleeding in 2nd or 3rd trimester, significant metabolic, cardiovascular, respiratory or systemic disorder) (5, 6). Pre-existing diabetes (except a history of GDM, but not in current pregnancy). Multiple gestations.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Lifestyle questionnaire on mothers and offspring. Tests on glucose tolerance and epigenetic analysis in offspring.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention<br>Lifestyle intervention | Behavioral: Exercise and dietary education<br>* Exercise and dietary education. Aerobic exercise or walk for 3-5 times/day for 30-45 min/time from 20 weeks to 36 weeks of pregnancy. Dietary education on nutrition for healthy pregnancy through weekly class during pregnancy.<br>|
| No Intervention: Control<br>No intervention | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Excessive weight gain during pregnancy |  | 2007-2023 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| macrosomia, requirement of delivery procedures |  | 2007-2025 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Exercise, Diet, Pregnancy, Obesity, Macrosomia