Measurement of the Energy Metabolism of Peritoneal Dialysis Patients

Study Overview
=================
Brief Summary
-----------------
The daily energy expenditure of patients treated with peritoneal dialysis could be increased compared to the general population and promote the development of a state of undernutrition. Conversely, the absorption of glucose by transperitoneal route could contribute to the occurrence of a metabolic syndrome. The main objective is to compare DE and its variations according to the conditions (rest, sleep, meals, physical activity) in patients treated with automated DP compared to controls, in a calorimetric chamber.

Detailed Description
-----------------
The daily energy expenditure of patients treated with peritoneal dialysis could be increased compared to the general population and promote the development of a state of undernutrition. Conversely, the absorption of glucose by transperitoneal route could contribute to the occurrence of a metabolic syndrome. The main objective is to compare DE and its variations according to the conditions (rest, sleep, meals, physical activity) in patients treated with automated DP compared to controls, in a calorimetric chamber.

Official Title
-----------------
Study in Calorimetric Room of the Energy Metabolism of Renal Impairment Patients Treated With Automated Peritoneal Dialysis

Conditions
-----------------
Renal Failure

Intervention / Treatment
-----------------
* Behavioral: automated DP
* Behavioral: Calorimetric chamber


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients Group DPA Male patients Aged 18 to 70 years With end-stage renal disease Treated by automatic peritoneal Social security cover Without acute events in the 3 months prior to inclusion PCR < 30 mg/L Written informed consent Baecke activity score from 5 to 10 Healthy Volunteers Male patients Aged 18 to 70 years Patients matched by lean body mass (± 2 kgs) and age (± 5 years) Having a glomerular filtration rate estimated with the formula CKD-EPI creatinine > 60 mL / min / 1.73 m 2 PCR < 3 mg/L Social security cover Written informed consent Baecke activity score from 5 to 10 Exclusion Criteria: • - Female Type 1 or 2 diabetes requiring a antidiabetic treatment Decompensated heart failure Smoking more than 5 cigarettes a day Alcoholic patients, drinking more than 3 glass of alcohol a day Patient Corticotherapy in progress Patient with evolutive acute pathology Person who has participated in another study within the last 30 days or is in period of exclusion on the National File of Healthy Volunteers

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patients Group DPA<br>The main objective is to compare DE and its variations according to the conditions (rest, sleep, meals, physical activity) in patients treated with automated DP compared to controls, in a calorimetric chamber | Behavioral: automated DP<br>* Energy expenditure measurement<br>|
| Experimental: Healthy Volunteers<br>The main objective is to compare DE and its variations according to the conditions (rest, sleep, meals, physical activity) in patients treated with automated DP compared to controls, in a calorimetric chamber | Behavioral: Calorimetric chamber<br>* The main objective is to compare DE and its variations according to the conditions (rest, sleep, meals, physical activity) in patients treated with automated DP compared to controls, in a calorimetric chamber<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Energy expenditure measured by indirect calorimetry in a calorimetric chamber | Energy expenditure measured by indirect calorimetry in a calorimetric chamber | at day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| respiratory quotient (RQ) | Nature of the oxidized nutrients determined from the measurement of the respiratory quotient | at day1 | 
| Actimetry | Estimated ambulatory energy expenditure from heart rate | at day 1 | 
| HGPO | Charges of blood insulin concentration, and glucose in response to oral glucose load | at day 1 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Energy expenditure, Peritoneal dialysis