Time,Self and Spontaneous Mental Activities in Patients With Psychotic Disorders

Study Overview
=================
Brief Summary
-----------------
The main purpose of the study is to examine to which extent abnormalities in the dynamics of neural activities observed in patients with psychosis is related to difficulties at ordering simple visual stimuli and/or personal events.

Official Title
-----------------
Time,Self and Spontaneous Mental Activities in Patients With Psychotic Disorders

Conditions
-----------------
Schizophrenia, Bipolar Disorder

Intervention / Treatment
-----------------
* Other: fMRI
* Other: EEG


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age between 18 and 60 years Affiliation to a social security insurance Written consent given Only for patient : DSM criteria for schizophrenia or bipolar disorder Exclusion Criteria: Addiction problem Invalidating visual sensory problems Neurological history Pregnancy or breastfeeding Legal safeguard Participation in another clinical trial Contraindication to MRI

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Healthy volunteer<br> | Other: fMRI<br>* Connectivity between the areas related to information processing over time and the areas activated during the rest activity. We will verify whether the activation anomalies observed during time tasks predict anomalies in spontaneous activity dynamics.<br>Other: EEG<br>* link between EEG response anomalies related to information processing over time and response anomalies recorded during rest activity. We will check whether anomalies in EEG oscillatory responses during time tasks predict anomalies during the rest task.<br>|
| Experimental: Patients with schizophrenia<br> | Other: fMRI<br>* Connectivity between the areas related to information processing over time and the areas activated during the rest activity. We will verify whether the activation anomalies observed during time tasks predict anomalies in spontaneous activity dynamics.<br>Other: EEG<br>* link between EEG response anomalies related to information processing over time and response anomalies recorded during rest activity. We will check whether anomalies in EEG oscillatory responses during time tasks predict anomalies during the rest task.<br>|
| Experimental: Patient with bipolar disorder<br> | Other: fMRI<br>* Connectivity between the areas related to information processing over time and the areas activated during the rest activity. We will verify whether the activation anomalies observed during time tasks predict anomalies in spontaneous activity dynamics.<br>Other: EEG<br>* link between EEG response anomalies related to information processing over time and response anomalies recorded during rest activity. We will check whether anomalies in EEG oscillatory responses during time tasks predict anomalies during the rest task.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Abnormalities in connectivity during order judgement tasks will be taken as seeds to check whether they account for abnormalities in connectivity at rest, by means of mathematic modelization |  | After study completion (2 years) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of the brain' functional coupling dynamics over time (how neuronal networks and connectivity change over time) during rest. |  | After study completion (2 years) | 
| - Evaluation of the brain' functional coupling dynamics over time (how neuronal networks and connectivity change over time) during time ordering. |  | After study completion (2 years) | 
| Comparison of patients with schizophrenia vs. bipolar disorder |  | During fMRI and EEG sessions |