Eating With Eosinophilic Esophagitis (EoE)

Study Overview
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Brief Summary
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Is there a difference in the eating process for patients with active Eosinophilic Esophagitis (EoE) and those with inactive disease?

Detailed Description
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Eosinophilic esophagitis (EoE) patients develop adapted eating behaviors to prevent symptoms. These patients tend to cut their food small, chew extensively, take copious liquids with meals, and avoid foods that cause symptoms. No studies to date have directly evaluated these eating behaviors in patients with EoE with observation. Furthermore, none of the investigators' current metrics for patient symptom assessment visually evaluate the eating process nor are they compared before and after treatment. As a result, it is unclear if a patient's subjective perception of their eating difficulties and improvement matches with objective measures.

Official Title
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Eating Behavior in Patients With Eosinophilic Esophagitis.

Conditions
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Eosinophilic Esophagitis (EoE)

Intervention / Treatment
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* Behavioral: Observed eating session


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 years of age and older Patients suspected to have Eosinophilic Esophagitis Patients being treated for EoE with PPI or a steriod EoE patients that are in remission by having less than 22 on the EEsAI questionnaire Controls, patients that do not have EoE or other swallowing issues Exclusion Criteria: Clinical evidence of infectious process potentially contributing to dysphagia (candidiasis, CMV,herpes) Other cause of dysphagia identified at endoscopy (reflux esophagitis, stricture, web, ring, achalasia, esophageal neoplasm) EoE patients that do not eat sandwiches or feel they could not eat a sandwich.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Acitve EoE<br>Observed eating session of Jimmy John's turkey or vegetarian sandwich with water among individuals who have EoE who have not been treated or have not achieved remission from treatment. | Behavioral: Observed eating session<br>* Eating a Jimmy Johns turkey or vegetarian sandwich<br>|
| Remission EoE<br>Observed eating session of Jimmy John's turkey or vegetarian sandwich with water among individuals who have EoE who are have achieved remission from treatment. | Behavioral: Observed eating session<br>* Eating a Jimmy Johns turkey or vegetarian sandwich<br>|
| Controls<br>Observed eating session of Jimmy John's turkey or vegetarian sandwich with water among individuals without EoE. | Behavioral: Observed eating session<br>* Eating a Jimmy Johns turkey or vegetarian sandwich<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Observed eating session | number of bites of patient's with EoE and controls eating a Jimmy John's sandwich | 15-90 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Food slowness during eating session | number of bites that felt stuck among patients with EoE and controls when eating a Jimmy John's sandwich | 15-90 minutes | 
| Water during eating session | amount of water drank of patients with EoE and controls eating a Jimmy John's sandiwch | 15-90 minutes | 
| Eosinophilic Esophagitis activity Index (EEsAI) questionnaire | The EEsAI Pro uses the VDQ is visual dysphagia question AMS is avoidance, modification, slow eating question . These two along with questions on frequency of, duration of, pain associated with dysphagia make up the PRO (patient reported outcomes). The PRO is a number (0-100) calculated from the answer to the questions. A PRO < 20 defines asymptomatic EoE. | 10-15 minutes | 
| Eosinophilic Esophagitis Quality of Life questionnaire | Higher score denote better quality of life. 0-4 as follows 4=not at all, 3=Slightly 2=moderately, 1=Quite a bit, 0= Extremely | 10-15 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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EoE, Dysphagia