Intrapartum Oxytocin Administration Affects Primitive Neonatal Reflexes

Study Overview
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Brief Summary
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The aim of this study was to assess whether administration of oxytocin intrapartum (Oxt) has any effect on Neonatal Primitive Reflexes (RNP) and if dose dependent. The secondary objective is to assess the effects on exclusive breastfeeding at 3 months

Detailed Description
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Patients and Methods Prospective case-control study performed in a tertiary hospital. Cases: mother-child dyads in which Oxt had been administered during the birth process (n = 53). Controls: mother-child dyads without Oxt (n = 45). The RNP were recorded with a camcorder in biological nurturing position. An observer blinded to the group and the dose of Oxt codified the RNP (reach/not reached). To assess the type of breastfeeding telephone call was made at 3 months old RN.

Conditions
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Bonding, Oxytocin, Breastfeeding, Newborn, Perinatal

Intervention / Treatment
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* Drug: Oxytocin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy singleton term infant delivered vaginally with Apgar at 5 min> 7; Expressed desire to administer during pregnancy breastfeeding; Signed informed consent Exclusion Criteria: Preterm neonate; Fetal chromosomal or other abnormalities diagnosed in utero to modify their adaptation to extrauterine environment; Hospitalization of the mother in ICU; Hospitalization in the following 48 hours neonate at birth; Wish to artificial feeding before parturition; Language difficulties; Completion of caesarean delivery

Ages Eligible for Study
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Minimum Age: 1 Day
Maximum Age: 4 Days

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Not exposed to oxytocin<br>Mother-child dyads in which Oxt had not been administered during the birth process | Drug: Oxytocin<br>* Comparison of Primitive Newborn Reflexes between those exposed or not to Oxytocin<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Expression of Neonatal Primitive Reflexes (RNP) are modified by administration of Oxytocin during delivery. | Neonatal Primitive Reflexes studied were: 1) Endogenous: hand to mouth, extension / flexion of fingers, mouth open, tongue extrusion, arm circular motion, circular motion of the leg, flex foot / hand, 2) Antigravity: raise the head, 3) Motors: turn your head, nod, plantar pressure, Babinski, and 4) Rhythmic: suction, jaw movement and swallowing. An observer, blinded to the study group and the dose administered of Oxytocin, valued recordings, analyzing the state of consciousness at the beginning of the recording as Brazelton scale and form RNP dichotomous coding (achieved / not achieved). | 72 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Oxytocin intrapartum may have adverse influence on exclusive breastfeeding at 3 months. | To assess the type of feeding (exclusive breastfeeding versus other) at different time points (discharge, one month and three months) a telephone call was conducted at 3 months old of the newborn. | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Bonding, Oxytocin, Breastfeeding, Newborn, Delivery