Clinical, Meibographic and Interferometric Evaluation of Phlyctenular Keratitis in Children - MEIBO-ROSACEE

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to describe the clinical, meibographic and interferometric manifestations of phlyctenular keratitis in children.

Detailed Description
-----------------
The investigators are conducting a monocentric, transversal, epidemiologic study. 100 patients should be included: 50 children suffering from ocular rosacea, and 50 children with no palpebral or Meibomian disease. Witnesses will be matched on the age of the cases. Patient and controls will undergo a classic ophthalmologic examination with visual acuity measurement and slit lamp examination of both eyes and eyelids. Then, the child will go through a meibographic and interferometric evaluation of his two inferior eyelids. This evaluation is made by an optometrist with the Lipiview device, and lasts a few minutes.

Official Title
-----------------
Clinical, Meibographic and Interferometric Evaluation of Phlyctenular Keratitis in Children - MEIBO-ROSACEE

Conditions
-----------------
Ocular Rosacea, Keratoconjunctivitis, Meibomian Gland Dysfunction

Intervention / Treatment
-----------------
* Procedure: Ophthalmologic examination and meibographic and interferometric evaluation (Lipiview device)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Recruited from a specialized ophthalmologic consultation Rothschild Ophthalmologic Foundation, Paris, France. Cases : suffering from ocular or oculo-cutaneous rosacea Witnesses : without any present or past palpebral or meibomian disease Exclusion Criteria: Unable to achieve the meibographic and interferometric examination (Lipiview)

Ages Eligible for Study
-----------------
Minimum Age: 2 Years
Maximum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cases : suffering from ocular or oculo-cutaneous rosacea<br>Classic ophthalmologic examination with visual acuity measurement and slit lamp examination of both eyes and eyelids. Then, meibographic and interferometric evaluation of his two inferior eyelids with the Lipiview device. | Procedure: Ophthalmologic examination and meibographic and interferometric evaluation (Lipiview device)<br>* Classic ophthalmologic examination with visual acuity measurement and slit lamp examination of both eyes and eyelids. Then, meibographic and interferometric evaluation of his two inferior eyelids with the Lipiview device.<br>|
| Witnesses<br>Without any present or past palpebral meibomian Gland Dysfunction Classic ophthalmologic examination with visual acuity measurement and slit lamp examination of both eyes and eyelids. Then, meibographic and interferometric evaluation of his two inferior eyelids with the Lipiview device. | Procedure: Ophthalmologic examination and meibographic and interferometric evaluation (Lipiview device)<br>* Classic ophthalmologic examination with visual acuity measurement and slit lamp examination of both eyes and eyelids. Then, meibographic and interferometric evaluation of his two inferior eyelids with the Lipiview device.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical severity | Clinical severity is determined with a composite score, by the presence of chalazia, corneal lesions, neovascularization, phlyctena, loss of vision, superficial keratitis, anterior and posterior keratitis, meibomitis, palpebral margin keratinization, lagophthalmos, long term use of azithromycin treatment, treatment by ciclosporin eyedrops, intense cutaneous or ocular symptoms, long time evolution of the disease. | Day of inclusion | 
| Meibographic severity | The meibographic severity is determined by the level of Meibomian gland atrophy, data obtained with the Lipiview | Day of inclusion | 
| Interferometric severity | The interferometric severity is evaluated by the thickness of the lipid layer tear film, data obtained with the Lipiview | Day of inclusion | 
| Number of abortive blinks | Number of abortive blinks during the Lipiview exam | Day of inclusion | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Child, Meibomian Gland, Ocular Rosacea, Keratoconjunctivitis, Interferometry