Predictors of Postoperative Pain

Study Overview
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Brief Summary
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The purpose of the study is to prove that pain scores generated from painful stimuli applied preoperatively may help identify the inter-individual variability in pain perception.

Detailed Description
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Psychological factors and experimental pain models such as as electrical, pressure, heat, or cold stimuli have been identified as predictors of pain intensity and opioid consumption postoperatively. This study will investigate, in addition to the factors described above, the ability of pain scores generated from painful stimuli postoperatively in predicting postoperative pain.

Official Title
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Predictors of Postoperative Pain Following Abdominal Hysterectomy

Conditions
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Postoperative Pain

Intervention / Treatment
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* Device: Thermal Sensory Analyzer (Senselab)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients undergoing abdominal hysterectomy through a pfannenstiel incision American Society of Anesthesiologists (ASA)Class I-III Exclusion Criteria: Patients with a history of psychiatric disease Diabetic or alcoholic patients who may have impaired sensation due peripheral neuropathies chronic opioid or nonsteroidal antiinflammatory drug use chronic pain conditions

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Patients undergoing hysterectomy<br> | Device: Thermal Sensory Analyzer (Senselab)<br>* Thermal stimuli will be administered to the ventral surface of the dominant forearm and then to the lower abdomen (surgical site)using the Thermal Sensory Analyser. Each thermal testing trial will be separated by approximately 2 min and at a separate site. To measure the thermal pain threshold temperature, The thermode will be applied to the ventral surface of the dominant forearm and the temperature will be increased at 1°C/s from 35 to 50°C. To measure the Suprathreshold Thermal Pain Intensity and unpleasantness, Stimulus responses for noxious heat stimuli will be performed by applying phasic heat stimuli at 8 different temperatures (35, 43, 44, 45, 46, 47, 48, and 49°C).<br>* Other names: Modular Sensory Analyzer, Senselab;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pain scores from IV insertion |  | 15 minutes prior to induction | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anxiety |  | 24 to 48 hours before surgery | 
| Pain from thermal stimuli | Pain from thermal stimuli will be measure at two sites: site of surgery and at the forearm. | 24 to 48 hours before surgery | 
| Suprathreshold Thermal pain intensity | Suprathreshold Thermal pain intensity will be recorded at two site: site of surgery and forearm | 24 to 48 hours before surgery | 
| suprathreshold thermal unpleasantness intensity |  | 24 to 48 hours before surgery | 
| Expectation about pain |  | 24 to 48 hours before surgery | 
| postoperative pain | Postoperative pain will be measured upon arrival to the Post Anesthesia Care Unit (PACU)before morphine consumption and after morphine consumption, at rest and at movement. | within 1-2 hours after arrival to recovery room; and at 12 hours, 24 hours, 36 hours and 48 hours after surgery | 
| Morphine consumption |  | within 1-2 hours after arrival to recovery room; and at 12 hours, 24 hours, 36 hours and 48 hours after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pain, quantitative sensory testing