Ventricular Volume as Assessed by Cardiac Magnetic Resonance

Study Overview
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Brief Summary
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One of the many uses of cardiac magnetic resonance (CMR) is the assessment of right ventricular (RV) volumes. There are a number of congenital heart defects and acquired conditions in which management decisions are fundamentally based on ventricular volumes. The gold standard for assessment of RV volume is CMR. It has better near-field resolution than echo and excellent contrast between the blood pool and the myocardium. CMR is more suitable to the irregular geometry of the RV. The objectives of this study are (1) to assess ventricular volumes in the fasting state and after oral hydration in order to assess the effect of fluid status on ventricular volumes as measured by CMR; (2) to evaluate the effect of hydration on ventricular volumes compared the effect of with inter-observer and intra-observer variability, and; (3) to evaluate the effects of chamber volume on chamber deformation, including strain and peak strain rate. This study hypothesizes that (1) hydration status has an effect on right and left heart volumes, measured by CMR in healthy volunteers; (2) the effect of volume status will be a more significant contributor to variability in RV volumetry than that of inter-observer variability and intra-observer variability, and; (3) atrial and Ventricular deformation corrected for chamber size or volume is more accurate than when uncorrected for volume.

Detailed Description
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To assess ventricular volumes in the fasting state and after oral hydration in order to assess the effect of fluid status on ventricular volumes as measured by CMR. To evaluate the effect of hydration on ventricular volumes compared the effect of with inter-observer and intra-observer variability. To evaluate the effects of chamber volume on chamber deformation, including strain and peak strain rate.

Official Title
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MRI Assessment of the Effect of Preload on Ventricular Volumes and Function in Healthy Adult Volunteers

Conditions
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Arrhythmogenic Right Ventricular Cardiomyophathy (ARVC)

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participant must be healthy Exclusion Criteria: Individuals who are unable to participate in an overnight fast will be excluded Those with known or suspected structural heart disease will be excluded A screening form to identify pre-existing cardiac conditions will be completed by the subject prior to participation in this study. If a pre-existing condition cardiac condition is identified, or suspected they will be excluded from the study. If any functional abnormality is detected at any stage by echocardiography or by CMR the study will be terminated. Common anatomical variants, which are generally regarded as normal variants (such as a patent foramen ovale, or a persistent left superior vena cava) will not lead to exclusion from the study.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cardiac Magnetic Resonance<br>The CMR examinations will be performed in the cardiac MRI scanner (Siemens Avanto, 1.5 Tesla, Erlangen, Germany) at the Hospital for Sick Children. A brief echocardiogram will be performed using a GE Vivid 7 or Vivid E9 machine (General Electric Medical Systems, Wisconsin, USA) We will image from standard parasternal long axis and apical four-chamber before and after completed hydration. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fluid Status | To assess ventricular volumes in the fasting state and after oral hydration in order to assess the effect of fluid status on ventricular volumes as measured by CMR. | Day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hydration | To evaluate the effect of hydration on ventricular volumes compared the effect of with inter-observer and intra-observer variability. | Day 1 | 
| Chamber Deformation | To evaluate the effects of chamber volume on chamber deformation, including strain and peak strain rate | Day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ventricular Volume, Cardiac Magnetic Resonance, Echocardiogram