Modification of Rhythmic Risk Assessment by Ventricular Tachycardia Ablation

Study Overview
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Brief Summary
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Sudden cardiac death is a frequent cause of cardiovascular mortality. Numerous rhythmic risk assessment criterion have been described targeting the substratum, the cardiac nervous tone or the trigger of arrhythmias. Development of ventricular tachycardia ablation in the past few years show interesting results preventing the recurrence of ventricular arrhythmias.

Detailed Description
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Sudden cardiac death is a frequent cause of cardiovascular mortality. Numerous rhythmic risk assessment criterion have been described targeting the substratum, the cardiac nervous tone or the trigger of arrhythmias. Development of ventricular tachycardia ablation in the past few years show interesting results preventing the recurrence of ventricular arrhythmias. Rhythmic risk assessment criterions have never been studied in relation with ventricular tachycardia ablation. The purpose of this study is to explore the modifications of these criterions after ventricular tachycardia ablation.

Official Title
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Modification of Rhythmic Risk Assessment by Ventricular Tachycardia Ablation

Conditions
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Ventricular Tachycardia

Intervention / Treatment
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* Procedure: ventricular tachycardia ablation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients undergoing ventricular tachycardia, patients with ischemic cardiomyopathy according to European Society of Cardiology Guidelines, patients with implanted cardiac defibrillator. Exclusion Criteria: Contra-indication to stress test, permanent atrial fibrillation, permanent ventricular pacing, left bundle block.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: ventricular tachycardia ablation|The usual organization of hospitalization of the patients addressed for ventricular tachycardia ablation and his follow-up are not modified by the protocol. .|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| measure assessing change before and after Ventricular Tachycardia Ablation of the non-invasive parameters analysis of the rhythmic risk before and after Ventricular Tachycardia Ablation | non invasive parameters analysis of the rhythmic risk will be evaluated by the evaluation of the T wave alternans | 10 minutes and 60 minutes after the Ventricular Tachycardia Ablation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assessing the correlations of the modifications of the risk criterion after ablation with the recurrences of arrhythmias at one year follow-up | the recurrences of arrhythmias will be evaluated . There will be assessed by the informations reveled by the Implantable automatic defibrillator | 3 months, 6 months and 12 months after the Ventricular Tachycardia Ablation | 
| Study of the correlation between the modifications of non-invasive parameters analysis of the rhythmic risk and the success of the ablation procedure | Success of the ablation procedure is defined by the absence of inducible Ventricular Tachycardia at the end of the procedure. | 3 months, 6 months and 12 months after the Ventricular Tachycardia Ablation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ablation, sudden death, signal averaged ECG, T wave alternans, heart rate variability