Functional MRI Evaluation in Pyeloureteral Junction Syndrome in Children

Study Overview
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Brief Summary
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Pyelo-ureteral junction syndrome is the most common urological abnormality in children. Functional MRI has been evaluated several times, and had shown good correlation with scintigraphy, but tends to over estimate results. Moreover, those studies included a small number of cases. Its sensitivity to detect crossing polar vessel is limited. We aimed to evaluate, in patients between 0 and 1 year old, the correlation between MRI and scintigraphy differential renal function. Our secondary objectives are : evaluation of MRI performances to detect polar vessel ; comparison of surgery times depending of MRI only realisation or MRI and scintigraphy realisation.

Official Title
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Functional MRI Usage for Pyelo-ureteral Junction Syndrome : Results of Nancy Children Hospital Cohort

Conditions
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Stricture of Pelviureteric Juncture

Intervention / Treatment
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* Diagnostic Test: Functional MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: children between 0 and 17 years old followed for pyelo-ureteral junction syndrome Exclusion Criteria: none

Ages Eligible for Study
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Minimum Age: 1 Day
Maximum Age: 17 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| PUJS patients<br>Patients between 0 and 17 years old treated or followed for pyelo-ureteral junction syndrome. | Diagnostic Test: Functional MRI<br>* Anatomical MRI : T2 fiesta, SSFE, HASTE ; 3D T2 ; T1 FAT SAT ; LAVA Functional MRI : T1 FAT SAT with gadolinium<br>* Other names: Renal Scintigraphy;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MRI and scintigraphy differential renal function correlation | Evaluation of differential renal function between MRI and scintigraphy in children between 0 and 1 year old ; Pearson correlation coefficient | from january 2007 to december 2021 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MRI and scintigraphy differential renal function correlation in operated patient | Evaluation of differential renal function between MRI and scintigraphy in children operated for PUJS; Pearson correlation coefficient | from january 2007 to december 2021 | 
| Time difference in patient operated for PUJS depending on MRI realisation ou MRI and scintigraphy realisation | Comparison between the mean time between MRI and surgery, and mean time between MRI, scintigraphy and surgery | from january 2007 to december 2021 | 
| performance of MRI in detecting polar vessel | Polar vessel : comparison between MRI results and operatory observation, sensitivity et specificity analysis | from january 2007 to december 2021 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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PUJS, MRI, Scintigraphy, Polar Vessel