Clinical Utility of the 1-minute Sit to Stand Test as a Measure of Submaximal Exercise Tolerance in Patients With Cystic Fibrosis During Acute Pulmonary Exacerbation

Study Overview
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Brief Summary
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The aim of this study is to assess whether the 1 minute Sit to Stand (STS) test can be used as a measure of submaximal endurance during a pulmonary exacerbation of Cystic Fibrosis (CF) for patients in the acute care setting. We hypothesize that if the STS test is a valid measure of submaximal cardiovascular endurance, it will moderately correlate with 6 minute walk distance (6MWD).

Official Title
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Clinical Utility of the 1-minute Sit to Stand Test as a Measure of Submaximal Exercise Tolerance in Patients With Cystic Fibrosis During Acute Pulmonary Exacerbation

Conditions
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Cystic Fibrosis

Intervention / Treatment
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* Diagnostic Test: Sit to stand test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients age 6-35 with cystic fibrosis who are admitted for a pulmonary exacerbation and receive ongoing physical therapy throughout their admission. Exclusion Criteria: patients with cystic fibrosis who are under the age of 6, patients with cystic fibrosis who are not admitted for a pulmonary exacerbation, patients with cystic fibrosis who are not being followed regularly by physical therapy (>5x/week) throughout their inpatient admission, patients with cystic fibrosis who are unable to follow instructions for standardized testing, patients with cystic fibrosis who are not medically stable to participate in submaximal exercise testing. patients whose inpatient admission is anticipated to be <1 week. Patients who are readmitted to the hospital within the year will not be included in the study more than once.

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 6MWT and STS<br>All participates will receive 6MWT and STS test | Diagnostic Test: Sit to stand test<br>* Participants will complete a sit to stand test in addition to a 6 minute walk test<br>* Other names: 6 minute walk test;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 1-minute STS repetitions: | Number of STS completed | 1 minute | 
| 1 minute STS power: | number of STS completed in 1 minute multiplied by bodyweight in pounds | 1 minute | 
| 6 Minute Walk Distance (6MWD): | total distance in feet completed during test | 6 minutes | 
| 6MWT power | total distance in feet multiplied by bodyweight in pounds | 6 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart rate | beats per minute | 1 minute | 
| Oxygen saturation | percentage via pulse oximetry | 1-6 minutes | 
| Respiratory rate | breaths per minute | 1-6 min | 
| Rating of perceived exertion | rating via Borg scale for perceived exertion: 0-10 with 0 being no breathlessness and 10 being maximal breathlessness | 6 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cystic fibrosis, walk test