Identification of Volatile Organic Compounds in Exhaled Air During Exacerbation of Chronic Obstructive Pulmonary Disease

Study Overview
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Brief Summary
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Exacerbations of the disease are a hallmark of Chronic Obstructive Pulmonary Disease (COPD), affecting the decline of pulmonary function, quality of life and increasing morbidity. The use of validated biomarkers could help to identify the etiology of exacerbation and to prescribe antibiotherapy when indicated. The analysis of exhaled air allows measuring different volatile organic compounds (VOC) which reflect local or systemic inflammation and oxidative stress. The relationship between the presence of some of these compounds and the exacerbation of COPD has never been studied. The aim of this study is to identify a cluster of VOC in COPD patients during an acute exacerbation of the disease, compared to a stable condition (3 months after discharge). Investigators also will seek for a relationship between VOC and the etiology of exacerbation (bacterial, viral, inflammatory).

Official Title
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Identification of Volatile Organic Compounds in Exhaled Air During Exacerbation of Chronic Obstructive Pulmonary Disease

Conditions
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Chronic Obstructive Pulmonary Disease

Intervention / Treatment
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* Other: Measurement of VOC in exhaled air


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria of COPD group: COPD stages 2 and 3 of GOLD score (30 ≤ forced expiratory volume at one second (FEV1) < 80% of predicted value), exacerbation confirmed clinically (increased dyspnea, cough or expectorations > 48 hours) Inclusion Criteria of non COPD group: No smoker (<100 cigarettes/year) Exclusion Criteria of COPD group: Diagnosis of COPD not confirmed. Instable clinical status with respiratory failure and indication of mechanical ventilation. Bronchodilator treatment changed Antibiotic treatment started in the 10 last days before admission Exclusion Criteria of non COPD group: Chronic inflammatory disease Any respiratory disease Oral corticosteroid treatment during the last month

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COPD Patients<br>Patients with COPD, within 48h after hospital admission for exacerbation. | Other: Measurement of VOC in exhaled air<br>* Measurement of VOC in exhaled air during 10 min (tidal breathing) with a portable mass spectrometer<br>|
| non-COPD patients<br>Healthy person of the entourage of COPD patients. | Other: Measurement of VOC in exhaled air<br>* Measurement of VOC in exhaled air during 10 min (tidal breathing) with a portable mass spectrometer<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Spectrum of VOC measured with a portable mass spectrometer system | Spectrum of VOC in exhaled air in patients with COPD compared to those of control subjects. It is measured with a portable mass spectrometer system. | Day 1 (within 48 hours after hospital admission for exacerbation of COPD) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Variation in VOC spectrum in COPD patients measured with a portable mass spectrometer system | Variation in VOC spectrum in COPD patients during exacerbation and in stable condition (3 months later). It is measured with a portable mass spectrometer system. | 3 months after hospital discharge | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Chronic Obstructive Pulmonary Disease, COPD, Volatile Organic Compounds, Exacerbation