Effect of Prevacid on Prostaglandin Levels in Patient With Stress Ulcer

Study Overview
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Brief Summary
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The purpose of this study is to measure the prostaglandin levels in patients with stress ulcer and the effect of Prevacid on prostaglandin levels in patients with stress ulcer.

Detailed Description
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The prostaglandin system plays an important role in the gastric mucosa to strengthen its resistance against injury. Critically ill patients are at greatest risk of developing stress-related gastric mucosal lesions. Although the levels of prostaglandins in gastric mucosa in patients with stressed animal has been studied, prostaglandin levels in the gastric mucosa in patients with stress ulcer have not been studied and the effect of Prevacid on prostaglandin levels in gastric mucosa from patients with stress ulcer is unknown. We hypothesize that prostaglandin levels are low in the gastric mucosa in patients with stress ulcer, and Prevacid is an effective agents in increasing prostaglandin levels in the gastric mucosa in stress stress ulcer. Comparison(s): The prostaglandin levels in patients who treated with Prevacid for stress ulcer, compared to the prostaglandin levels in patients who treated with H2 blocker for stress ulcer.

Official Title
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Effect of Prevacid on Prostaglandin Levels in the Gastric Mucosa of Patients With Stress Ulcer

Conditions
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Stomach Ulcer

Intervention / Treatment
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* Drug: Prevacid


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients in ICU with documented gastric stress ulcer by endoscopic examination, including patients with H. Pylori infection; Patients have no known ulcer within 8 weeks prior to be admitted to ICU; Patients not on any PPI for 4 weeks prior to the study; Patients or family be consented for the study. Exclusion Criteria: Patients have gastric ulcer within 8 weeks prior to be admitted to ICU; Patients have gastric cancer confirmed by pathology; Patients on one of the PPIs already; Patients on any of the Non-steroidal Antiinflammatory Drugs.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Prevacid<br>Effect of Prevacid at 8 weeks; EGD(esophagogastroduodenal endoscopy) at day 1 & EGD at 8 weeks | Drug: Prevacid<br>* Effect of Prevacid on prostaglandin levels at 8 weeks; EGD (esophagogastroduodenal endoscopy) with biopsy at day 1 & EGD with biopsy at 8 weeks<br>* Other names: Lansoprazole;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the effect of Prevacid on prostaglandin levels at 8 weeks |  | 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| esophagogastroduodenal endoscopy(EGD) with biopsy at day 1; EGD with biopsy at 8 weeks |  | 8 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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gastric stress ulcer, Prevacid, Prostaglandin