Adequate Dosage of Sugammadex on Thyroid Surgery

Study Overview
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Brief Summary
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This study was designed to compare two dosage of sugammadex after tracheal intubation for optimal condition of continuous intraoperative neuromonitoring in thyroid surgery to protect recurrent laryngeal nerve.

Detailed Description
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Vocal cord paralysis is not a rare complication in thyroid surgery. Nerve monitoring technique has been developed, and many clinicians use the technique for saving the concerned nerves. Many studies showed that the effect of sugammadex on reverse of neuromuscular blocking after tracheal intubation. However, optimal dosage was not founded for sugammadex. This randomized controlled trial is to compare 1 mg/kg and 2 mg/kg as dosage of sugammadex for optimal continuous intraoperative neuromonitoring in thyroid surgery to prevent vocal cord paralysis.

Official Title
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Comparison of Sugammadex Dosages to Reverse the Effect of Rocuronium for Continuous Intraoperative Neuromonitoring in Thyroid Surgery

Conditions
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Thyroid Surgery

Intervention / Treatment
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* Drug: Sugammadex 200 MG in 2 ML Injection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The patients who need to open thyroid surgery Exclusion Criteria: Who doesn't agree to enroll Who has to receive other drug rather than rocuronium for muscle relaxant

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1 mg/kg<br>For '1 mg/kg' group, sugammadex of 1 mg/kg (ex. 60 mg for 60 kg patient) will be administered to the assigned patient for this group after tracheal intubation. We will use Sugammadex 200 MG in 2 ML Injection for this. | Drug: Sugammadex 200 MG in 2 ML Injection<br>* 1 mg/kg or 2 mg/kg intravenous injection for each group (1 mg/kg group, 2 mg/kg group) after tracheal intubation<br>* Other names: Bridion;|
| Active Comparator: 2 mg/kg<br>For '2 mg/kg' group, sugammadex of 2 mg/kg (ex. 120 mg for 60 kg patient) will be administered to the assigned patient for this group after tracheal intubation. We will use Sugammadex 200 MG in 2 ML Injection for this. | Drug: Sugammadex 200 MG in 2 ML Injection<br>* 1 mg/kg or 2 mg/kg intravenous injection for each group (1 mg/kg group, 2 mg/kg group) after tracheal intubation<br>* Other names: Bridion;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of signal of neuromonitoring | During operation, surgeon evaluate the quality of signal of neuromonitoring on the basis of NIM III device. | intraoperative | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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neuromonitoring, thyroid surgery