Effects of Dexmedetomidine on Quality of Recovery and Analgesia After Video-assisted Thoracoscopic Surgery

Study Overview
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Brief Summary
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Dexmedetomidine is a selective α2 adrenergic agonist that can be considered analgesics, anxiolytic,and anti-stress effect . This randomized, double-blind placebo-controlled trial of intraoperative dexmedetomidine for improvement of quality of recovery and analgesia from surgery. Patients scheduled to undergo video-assisted thoracoscopic surgery (VATS) will be enrolled. Patients will be recruited before the date of their surgery and will complete the Quality of Recovery-40 (QoR-40) questionnaire before their surgery and at 24 and 48 hours post op. They will also complete clinically significant pains score and oxygenation from the postanesthetic recovery unit (PACU).

Conditions
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Lung Cancer, Video-assisted Thoracoscopic Surgery

Intervention / Treatment
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* Drug: Dexmedetomidine
* Drug: Normal saline


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The inclusion criteria included patients scheduled video-assisted thoracoscopic surgery for lung cancer Adults above 20 years of age and providing informed consent. American Society of Anesthesiologists (ASA) Physical class II, & III patients Exclusion Criteria: severe functional liver or kidney disease history of chronic pain requiring opioid treatment arrhythmia or received treatment with antiarrythmic drug . severe bradycardia (HR < 45 bpm) and AV block pathologic esophageal lesion (esophageal stricture or varix ) pregnancy psychiatric/central nervous system disturbance that would preclude completion of the QoR-40 questionnaire History of alcohol or drug abuse

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Dexmedetomidine<br> | Drug: Dexmedetomidine<br>* Formula for administrated were randomized by computer-generated randomization. The patients and anesthesiologist, who administered and conducted all this trial, were blinded to the medication allocation. An anesthesiologist, who responsible for preparation of medication was the only person, recognized of the randomization code during trial. After one-lung ventilation, dexmedetomidine group would start the loading of dexmedetomidine (1μg/kg) during 20 minutes.<br>* Other names: Precedex;|
| Sham Comparator: Saline 0.9%<br> | Drug: Normal saline<br>* Saline placebo infusion will be adjusted the same fashion as the active comparator drug.<br>* Other names: Saline 0.9%;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| quality of recovery measured by QoR-40 questionnaire |  | 24 hr after operation | 
| pulmonary function test | postoperative lung function assessed by spirometry | 24 hr after operation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dexmedetomidine, quality of recovery