Methodological Developments for Magnetic Resonance Imaging (MRI)

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to optimize clinical MR protocols and to validate MR acquisition parameters.

Official Title
-----------------
Développement Méthodologique de l'Imagerie Par Résonance Magnétique (IRM)

Conditions
-----------------
Healthy Subjects

Intervention / Treatment
-----------------
* Device: MRI


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: to be over 18 year-old, to be able to give an informed consent, to have underwent a pre-inclusion medical examination, to present no contraindication to MR examination, to be enrolled in a social security plan. Exclusion Criteria: subject refusal, subject under a measure of legal protection, any contraindication to MR examination (active medical device, ferromagnetic foreign body, pregnancy, morbid obesity, claustrophobia, … ).

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: All subjects<br>All subjects will have an MRI examination | Device: MRI<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Image quality based on standard imaging quality criteria | Image quality criteria will be : Signal to Noise Ratio and Contrast to Noise Ratio measured in arbitrary units. absence of blurring and artefacts will be assessed by at least one radiologist according to an ordinal scale | 6 months after the last inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| T1/T2 Quantitative sub studies | For quantitative studies such as T1/T2 studies a T1/T2 quantification will be calculated. These parameters will be reported in ms. | 6 months after the last inclusion | 
| Brain Functional MRI sub studies | For functional MRI studies, brain activity will be described in terms of brain localisation based on blood oxygen level-dependent signal variation and its intensity. | 6 months after the last inclusion | 
| Cardiac function MRI sub studies: volume | For cardiac imaging, cardiac function will be evaluated. Parameters such as left ventricle (LV) and right ventricle (RV) end-diastolic volumes end-systolic volumes will be measured and reported in mL/m². | 6 months after the last inclusion | 
| Cardiac mass MRI sub studies: mass | For cardiac imaging, cardiac function will be evaluated. LV and RV mass index will be measured and reported in g/m2. | 6 months after the last inclusion | 
| Cardiac function MRI sub studies: ejection fraction | For cardiac imaging, cardiac function will be evaluated. Ejection fraction for both ventricles will be calculated and reported in %. | 6 months after the last inclusion | 
| Diffusion weighted MRI sub studies | For diffusion studies, the apparent diffusion coefficient (ADC) whic is a measure of the magnitude of diffusion (of water molecules) within tissue will be estimated (mm2/s). | 6 months after the last inclusion | 
| Diffusion tensor MRI sub studies | The fractional anisotropy (FA) which is a scalar value between zero and one, which describes the degree of anisotropy of a diffusion process, could also be estimated. | 6 months after the last inclusion | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
MRI, Healthy subjects