Medium Chain Triglycerides and Brain Metabolism in Alzheimer's Disease

Study Overview
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Brief Summary
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Evaluate and compare the changes in brain ketone and glucose uptake after taking two different MCT oil emulsions (60-40 oil or C8 oil) for one month, in a group of people with Alzheimer's disease and a control group.

Detailed Description
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Based on a PET/MRI protocol, the aim of this study is to evaluate and compare the response to the dietary supplementation of two different MCT oils (60% C10 + 40% C8 or 100 % C8) in two groups, patients with Alzheimer's disease and healthy elderly people (N=10/group). After a baseline evaluation, participant will test one of the supplements during two successive periods of one month; each period of time ending with 18F-FDG and 11C-acetoacetate PET scans.

Official Title
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Proof of Concepts: Can a Supplement Ketogenic Based MCT Oil Increases Cerebral Capture Ketones in People With Alzheimer's Disease?

Conditions
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Alzheimer's Disease

Intervention / Treatment
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* Dietary Supplement: 1-month of 60-40 MCT oil
* Dietary Supplement: 1-month of C8 MCT oil


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Good general health for Control group Diagnosis of Alzheimer's disease (NINCDS-ADRDA criteria) for AD group Exclusion Criteria: Depression Medical or psychiatric conditions that could interfere with study participation Fasting plasma glucose ≥7.0 mM (diabetes or prediabetes) Already on MCT supplementation Clinically-significant gastrointestinal disease/conditions Clinically-significant liver disease/dysfunction Clinically-significant renal disease/dysfunction Clinically-significant cardiac disease/conditions Hypertension Uncontrolled dyslipidaemia Vitamin B12 deficiency Structured physical activity (more than 3 times/week)

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Alzheimer's disease<br>Patients with mild Alzheimer's disease. 1-month of 60-40 MCT oil and 1-month of C8 MCT oil (order of the two intervention are randomized) | Dietary Supplement: 1-month of 60-40 MCT oil<br>* 1-month supplementation of 30 g MCT oil (60% C10 + 40% C8)/day<br>Dietary Supplement: 1-month of C8 MCT oil<br>* 1-month supplementation of 30 g MCT oil (100% C8)/day (1-month of C8 MCT oïl)<br>|
| Experimental: Controls<br>Healthy elderly people 1-month of 60-40 MCT oil and 1-month of C8 MCT oil (order of the two intervention are randomized) | Dietary Supplement: 1-month of 60-40 MCT oil<br>* 1-month supplementation of 30 g MCT oil (60% C10 + 40% C8)/day<br>Dietary Supplement: 1-month of C8 MCT oil<br>* 1-month supplementation of 30 g MCT oil (100% C8)/day (1-month of C8 MCT oïl)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quantification of brain glucose uptake | Brain glucose uptake (umol/100g/min) using 18-FDG PET scan | 1-month | 
| Quantification of brain acetoacetate uptake | Brain acetoacetate uptake (umol/100g/min) using 11C-AcAc PET scan | 1-month |