Neurally Adjusted Ventilatory Assist for Non Invasive Ventilation and Patient-ventilator Interaction

Study Overview
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Brief Summary
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The present study aims to compare various parameters reflecting patient-ventilator synchrony during standard pressure support (PS) and Neurally Adjusted Ventilatory assist (NAVA) in a group of patients receiving non invasive ventilation (NIV)for an episode of acute respiratory failure of various origin.

Detailed Description
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The present study aims to compare various parameters reflecting patient-ventilator synchrony during standard pressure support (PS) and Neurally Adjusted Ventilatory assist (NAVA) in a group of patients receiving non invasive ventilation (NIV)for an episode of acute respiratory failure of various origin. The subgroup of COPD patients will be analyzed separately. The effects of various setting of Neurally adjusted ventilatory assist on patient-ventilator interaction will also be explored.

Official Title
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The Effects of Neurally Adjusted Ventilatory Assist (NAVA) on Improving Patient-ventilator Interaction in Patients Undergoing Ventilation for Acute Respiratory Failure

Conditions
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Non Invasive Ventilation, Patient Ventilator Interaction

Intervention / Treatment
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* Device: Neurally Adjusted Ventilatory Assist


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients admitted to the ICU and treated with Non invasive ventilation for acute respiratory failure of any origin Exclusion Criteria: severe hypoxemia requiring an FIO2>0.6 hemodynamic instability known oesophageal problem active upper gastro-intestinal bleeding any other contraindication to the insertion of a naso-gastric tube impaired consciousness or absence of patient cooperation facial or laryngeal lesions contraindicating the use of NIV poor short term prognosis

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Pressure support<br>Non invasive ventilation under pressure support (PS) | |
| Active Comparator: Neurally Adjusted Ventilatory Assist<br>Non invasive ventilation under Neurally Adjusted ventilatory Assist | Device: Neurally Adjusted Ventilatory Assist<br>* Non invasive ventilation under Neurally adjusted Ventilatory Assist<br>* Other names: NAVA;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient-ventilator synchronization parameters |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Mechanical ventilation, Non invasive Ventilation, Patient-ventilator interaction, Pressure support, Neurally adjusted ventilatory assist