Sarcopenic Obesity: Estimation of Prevalence and Identification of Clinical and Biological Determinants in a Population of Adult Obese Patients

Study Overview
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Brief Summary
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This project aims first to determine the prevalence of sarcopenia in a population of obese people of extended age group (18-70 years). In a second step, the factors determining and / or predisposing to sarcopenic obesity will be identified as well as plasmatic and urinary biomarkers specific to this phenotype.

Detailed Description
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Collection of clinical and paraclinical data (biological and anthropometric) for evaluation of sarcopenic obesity in obese patients. Biological collection to identify plasma, serum, genetic, urinary and faecal biomarkers associated with sarcopenic obesity

Official Title
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Sarcopenic Obesity: Estimation of Prevalence and Identification of Clinical and Biological Determinants in a Population of Adult Obese Patients

Conditions
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Obesity

Intervention / Treatment
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* Other: collection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age: 18-70 years Sex: men and women Patient followed in clinical nutrition benefiting from a metabolic assessment for optimization of clinical and paraclinical management Patient meeting the criteria of obesity defined by BMI> 30 kg / m² Major patient with free, informed and signed consent Patient covered by the social security scheme Exclusion Criteria: Patient with cancer or severe chronic disease (renal failure, respiratory failure, liver failure) Patient with neuromuscular disease Patient with a total inability to walk Minor patient Refusal of the patient to participate in the study Pregnant or lactating women Patient deprived of liberty or under guardianship.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: cohort<br>Collection of clinical and paraclinical data (biological and anthropometric) for evaluation of sarcopenic obesity in obese patients. | Other: collection<br>* Blood, urinary and faecal samples<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sarcopenia | The primary endpoint is sarcopenia (present / absent), defined using the muscle mass index (SMI) corresponding to = SM / Height², where the total muscle mass (SM) is calculated from validated equations. by Janssen et al in a population of men and women with a large age range (18-86 years) and adiposity (BMI: 16-48 kg / m integrating bio-impedancemetry data ( BIA). | at day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Obesity, Sarcopenia