Data Visualization of Kidney and Prostate Tumors Using Routine Pre-Operative Imaging, 3D Printed, and 3D Virtual Reality Models

Study Overview
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Brief Summary
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The purpose of this study is to determine whether adding new methods of data visualization to routine clinical care will improve (i) surgical planning and (ii) surgical outcomes in patients with kidney and prostate tumors.

Detailed Description
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This early phase I trial studies how well indwelling pleural catheters with doxycycline work compared to indwelling pleural catheters alone in treating participants with malignant pleural effusions. These types of catheters are commonly used to treat pleural effusions (build-up of fluid in the lungs). Doxycycline is an antibiotic that is also used to treat pleural effusions. It is not yet known whether giving doxycycline with indwelling pleural catheters works better than indwelling pleural catheters alone in treating participants with cancerous pleural effusions.

Official Title
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Data Visualization of Kidney and Prostate Tumors Using Routine Pre-Operative Imaging, 3D Printed, and 3D Virtual Reality Models

Conditions
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Pleural Effusion

Intervention / Treatment
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* Diagnostic Test: Routine CT
* Diagnostic Test: Routine imaging CT with a 3D printed model
* Diagnostic Test: Routine imaging MRI with a 3D printed model
* Diagnostic Test: Routine MRI
* Diagnostic Test: Routine imaging CT with a VR model
* Diagnostic Test: Routine imaging MRI with a VR model


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Outpatients with MPE undergoing IPC placement Sufficient mental capacity to provide informed consent and answer Short-Form Six-Dimension health index (SF-6D) and Borg score questions Exclusion Criteria: Patients undergoing pleurodesis for benign disease (e.g., spontaneous pneumothorax) Inability or unwillingness to give informed consent Inability to perform phone call and clinical follow-up at MD Anderson Cancer Center (MDACC) Pregnancy Previous intrapleural therapy for MPE on the same side Eastern Cooperative Oncology Group (ECOG) of 4 and life expectancy ≤ 2 weeks Doxycycline allergy Extensive loculations or hydropneumothorax or other contraindication to pleurodesis Chylous effusions associated with malignant disease

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Routine imaging such as CT or MRI<br>Subjects will undergo routine pre-operative imaging and will be randomized into 3 groups for data visualization. This group will receive data visualization using routine clinical imaging, | Diagnostic Test: Routine CT<br>* CAT (Computerized Axial Tomography) scan, is a noninvasive X-ray test that is used to diagnose a variety of medical conditions.<br>Diagnostic Test: Routine MRI<br>* will measure post-operative lesion volume as visualized on the post-operative MRI<br>|
| Routine imaging (CT or MRI) with a 3D printed model<br>Subjects will undergo routine pre-operative imaging and will be randomized into 3 groups for data visualization. This group will receive data visualization using routine clinical imaging with a 3D printed anatomical mode | Diagnostic Test: Routine imaging CT with a 3D printed model<br>* CAT (Computerized Axial Tomography) scan, is a noninvasive X-ray test that is used to diagnose a variety of medical conditions + 3D Printed Model<br>Diagnostic Test: Routine imaging MRI with a 3D printed model<br>* will measure post-operative lesion volume as visualized on the post-operative MRI + 3D Printed Model<br>|
| Routine imaging (CT or MRI) with a VR model<br>Subjects will undergo routine pre-operative imaging and will be randomized into 3 groups for data visualization. This group will receive data visualization using routine clinical imaging with a 3D VR anatomical model | Diagnostic Test: Routine imaging CT with a VR model<br>* CAT (Computerized Axial Tomography) scan, is a noninvasive X-ray test that is used to diagnose a variety of medical conditions + VR Model<br>Diagnostic Test: Routine imaging MRI with a VR model<br>* will measure post-operative lesion volume as visualized on the post-operative MRI + VR Model<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measure of Operative Time | measure of the amount of time it takes surgeon to remove tumor | Post Surgery |