miRNA in Fetal Overgrowth

Study Overview
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Brief Summary
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The purpose of this study is to determine whether placental and umbilical cord blood miRNA expression is altered in women with obesity with macrosomic neonates to when compared to miRNA expression from control patients.

Detailed Description
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MicroRNA's are a class of non-coding RNA's that function as translational repressors and are thought to modulate tissue development, proliferation, differentiation and function. Differential expression of certain placental miRNA's has been associated with preeclampsia. The fetal origins of adult disease hypothesis suggests that risk factors from intrauterine environmental exposures affect the fetus' development during sensitive periods, and increases the risk of specific diseases in adult life. Our aim is to understand factors that predispose fetuses to fetal overgrowth in utero, especially in women with obesity. The objective of the study is to identify miRNA which are differentially expressed in the placenta and cord blood of pregnancies that are affected by fetal macrosomia to determine factors that may predispose fetuses to fetal overgrowth.

Official Title
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Placental miRNA (microRNA) Profile in Fetal Overgrowth Related to Maternal Obesity Study

Conditions
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Obesity

Intervention / Treatment
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* Behavioral: Neonatal exposure to maternal obesity


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: singleton pregnancy prenatal care & delivery at the Hospital of the University of Pennsylvania system Normal glucose tolerance test results (less than 120 mg/dl) Exclusion Criteria: Multiple gestation under 18 years old, or over 45 years old chronic hypertension preeclampsia chronic steroid use diabetes major fetal anomaly connective tissue disorder requiring medication active HIV Hepatitis C

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Obese mother/ Macrosomic baby<br>Obese mother that delivers a macrosomic neonate to understand the effects neonatal exposure to maternal obesity. | Behavioral: Neonatal exposure to maternal obesity<br> <br> |
| Obese mother/ normal weight baby<br>Obese mother that delivers a normal weight neonate to understand effects neonatal exposure to maternal obesity. | Behavioral: Neonatal exposure to maternal obesity<br> <br> |
| Normal weight mother/ Macrosomic baby<br>Normal weight mother that delivers a macrosomic neonate | |
| Normal weight mother/ Normal weight baby<br>Normal weight mother who delivered a normal weight neonate | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fetal Overgrowth | Placental and cord blood samples will be studied for miRNA expression. The objective of the study is to identify miRNA which are differentially expressed in the placenta and cord blood of pregnancies that are affected by fetal macrosomia to determine factors that may predispose fetuses to fetal overgrowth. | Delivery date to up to 6 weeks post partum | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Maternal obesity, Macrosomic, miRNA, Fetal overgrowth