Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients

Study Overview
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Brief Summary
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The objective of CAREBANK study is to establish definitive relationships with human cardiac samples and clinical phenotypes in patients undergoing cardiac procedures. Specifically, the investigators aim at comparing atrial phenotypes from atrial fibrillation patients and controls. The work consists of three broad categories: A) role of atrial cardiomyopathy in atrial fibrillation; B) genetic defects predisposing to atrial fibrillation; and C) the role of inflammation in atrial fibrillation.

Detailed Description
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The investigators aim to A) compare atrial cardiomyopathy findings from the tissue samples to clinical phenotype and adverse events B) study the association of genetic defects predisposing to atrial fibrillation with atrial cardiomyopathy findings in the tissue samples C) assess the role of inflammation in atrial fibrillation by comparing circulating cytokine profiles, purinergic signaling and atrial cardiomyopathy findings in tissue samples.

Official Title
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Cardiovascular Research Consortium - a Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients

Conditions
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Atrial Fibrillation, Coronary Artery Disease, Aortic Valve Stenosis, Aortic Valve Disease, Mitral Valve Disease, Cardiac Arrythmias, Cardiac Tumor, Cardiac Surgery

Intervention / Treatment
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* Procedure: Cardiac surgery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Any open-heart cardiac surgery Written informed consent All-comers design Exclusion Criteria: No informed consent

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Atrial fibrillation<br>Patients with atrial fibrillation | Procedure: Cardiac surgery<br>* Open heart surgery<br>|
| Coronary bypass<br>Patients undergoing coronary bypass | Procedure: Cardiac surgery<br>* Open heart surgery<br>|
| Aortic valve replacement<br>Patients undergoing aortic valve replacement | Procedure: Cardiac surgery<br>* Open heart surgery<br>|
| Mitral valve repair<br>Patients undergoing mitral valve repair | Procedure: Cardiac surgery<br>* Open heart surgery<br>|
| Other<br>Patients undergoing cardiac surgery for indication other than above | Procedure: Cardiac surgery<br>* Open heart surgery<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Atrial fibrillation | Occurrence of atrial fibrillation | postoperatively until 5 years follow-up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Stroke | Occurrence of stroke | postoperatively until 5 years follow-up | 
| Transient ischemic attack | Occurrence of Transient ischemic attack | postoperatively until 5 years follow-up | 
| Myocardial infarction | Occurrence of Myocardial infarction | postoperatively until 5 years follow-up | 
| Target vessel revascularization | Occurrence of Target vessel revascularization | postoperatively until 5 years follow-up | 
| All-cause Mortality | All-cause Mortality | postoperatively until 5 years follow-up | 
| Post-pericardiotomy syndrome | Occurrence of Post-pericardiotomy syndrome | postoperatively until 1 years follow-up | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Atrial fibrillation, Aortic stenosis, Coronary artery disease, Cardiac surgery, Atrial appendage