Antioxidant Profile in Patients With Systemic Sclerosis and Periodontitis

Study Overview
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Brief Summary
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The aim of the research will be to compare periodontal status and level of antioxidants in unstimulated saliva of systemic sclerosis patients with periodontitis and systemically healthy periodontitis patients. Twenty systemic sclerosis patients with periodontitis (SS group) and twenty systemically healthy periodontitis patients (P group) will be enrolled in the present study. The results may indicate higher periodontal destruction and antioxidant perturbations in unstimulated saliva of systemic sclerosis patients with periodontitis compared to systemically healthy periodontitis patients.

Official Title
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Antioxidant Profile in Unstimulated Saliva in Patients With Systemic Sclerosis and Periodontitis

Conditions
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Systemic Sclerosis, Periodontitis

Intervention / Treatment
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* Diagnostic Test: periodontal examination's and determination of salivary antioxidants


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: established diagnoses of systemic sclerosis and periodontitis (study group), age ≥ 18 presence of minimum 12 teeth Exclusion Criteria: concurrent inflammatory mediated rheumatic diseases pregnancy or lactation active cigarette smokers a history of periodontal, antibiotics or non-steroidal drug therapy in the past 6 months.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| systemic sclerosis group<br>Patients with established diagnoses of systemic sclerosis and periodontitis | Diagnostic Test: periodontal examination's and determination of salivary antioxidants<br>* Periodontal parameters such probing depth (PD), clinical attachment level (CAL) and gingival margin level has been recorded on six sites of each tooth using a manual periodontal probe. The degree of gingival inflammation has been assessed using the Loe and Silness (LSGI) gingival index. Activity of antioxidants in unstimulated saliva (GPX, SOD, UA) has been determined using the colorimetric method and commercial kits.<br>|
| periodontitis group<br>Systemically healthy periodontitis patients | Diagnostic Test: periodontal examination's and determination of salivary antioxidants<br>* Periodontal parameters such probing depth (PD), clinical attachment level (CAL) and gingival margin level has been recorded on six sites of each tooth using a manual periodontal probe. The degree of gingival inflammation has been assessed using the Loe and Silness (LSGI) gingival index. Activity of antioxidants in unstimulated saliva (GPX, SOD, UA) has been determined using the colorimetric method and commercial kits.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical attachment level (CAL) | Measuring the CAL by periodontal probe, measured in mm | one day | 
| Probing depth (PD) | Measuring the PD by periodontal probe, measured in mm | one day | 
| Gingival margin level (GML) | Measuring the GML by periodontal probe, measured in mm | one day | 
| The degree of gingival inflammation | The degree of gingival inflammation was assessed using the Loe and Silness (LSGI) gingival index. | one day | 
| plaque index (PI) | Evaluation of oral hygiene status was recorded with a Silness Loe plaque index (PI). | one day | 
| glutathion peroxidase (GPX) | Activity level of GPX, determined using the colorimetric method and commercial kits. | one day | 
| superoxide dismutase (SOD) | Activity level of SOD, determined using the colorimetric method and commercial kits. | one day | 
| uric acid (UA) | Activity level of UA, determined using the colorimetric method and commercial kits. | one day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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systemic sclerosis, periodontitis, antioxidants, saliva