Clinical and Radiographic Evaluation of Advanced Platelet Rich Fibrin in the Preservation of Alveolar Ridge Following Atraumatic Tooth Extraction

Study Overview
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Brief Summary
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compare the effect of application of A-PRF in socket preservation after atraumatic tooth extraction and natural healing regarding to bone remodeling . Null hypotheis, after atraumatic extraction, socket with advanced PRF has no difference with socket with blood clot in primary outcome

Official Title
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Clinical and Radiographic Evaluation of Advanced Platelet Rich Fibrin in the Preservation of Alveolar Ridge Following Atraumatic Tooth Extraction: A Randomized Clinical Trial

Conditions
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Socket Preservation

Intervention / Treatment
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* Procedure: Socket preservation with APRF
* Procedure: natural healing


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The inclusion criteria are as follow : patients with an unremarkable medical history subjects with at least one site bordered by minimum of one tooth. Nonsmoker Teeth with root fracture, teeth with failed endodontic therapy or advanced caries Intact extraction socket with no dehiscence or fenestration. The buccolingual thickness of the buccal plate of bone in surgical area is 1 mm or more Exclusion Criteria: Patients with systemic diseases. Patients with presence or history of osteonecrosis of the jaws, with use of bisphosphonates, exposure to head and neck radiation, chemotherapy. patients with large distinct pre-apical pathology

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: test group<br>Socket preservation with APRF | Procedure: Socket preservation with APRF<br>* Socket preservation with APRF , A-PRF membranes were implanted into the extraction socket following tooth extraction. One entire A-PRF membrane would be placed at the base of the extraction socket and another A-PRF membrane will cover the extraction site then suturing will be done .Venous blood will be collected via venipuncture of the forearm with a butterfly needle into at least 10 mL sterile glass vacuum tube. The blood sample will be immediately centrifuged at 1,300 rpm (200 x g) for 8 minutes<br>|
| Active Comparator: control group<br>natural healing | Procedure: natural healing<br>* after atraumatic extraction , the socket will be left for natural healing after suturing<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mesial and distal height of extraction site | digital radiograph | 2 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| soft tissue thickness | will be evaluated by endo file with rubber stopper and digital caliper | 2 months |