The Efficacy of Adductor-Canal-Block (ACB) in Patients After Knee Arthroscopy

Study Overview
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Brief Summary
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The Purpose of this study is to determine whether Adductor-Canal-Block (ACB) is superior to placebo when it comes to analgetic efficacy after Knee-Arthroscopy.

Official Title
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The Efficacy of Adductor-Canal-Block (ACB) in Patients After Knee Arthroscopy

Conditions
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Meniscus Lesion, Pain (Knee), Diagnostic Knee Artroscopy, Minor Knee Surgery

Intervention / Treatment
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* Procedure: Adductor-Canal-Block, Ropivacain
* Procedure: Adductor Canal Block, Placebo (saline)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18-80 years Knee-arthroscopy Written consent ASA I-III BMI 19-35 Exclusion Criteria: Unable to communicate in Danish Allergic reactions toward drugs used in the trial Pregnancy Abuse of alcohol/drugs Daily opioid intake Infection at injection site Can not be mobilised to 5 meters of walk; pre-surgery

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Adductor-Canal-Block, Ropivacain<br>Adductor-Canal-Block, 30 mL Ropivacain 7,5 mg/mL. Single dose. Ultrasound-guided application. 36 patients | Procedure: Adductor-Canal-Block, Ropivacain<br>* Ultrasound-guided ACB; 30 mL Ropivacain 7,5 mg/mL. Single dose.<br>* Other names: Naropin (Ropivacain);|
| Placebo Comparator: Adductor-Canal-Block (ACB) - Saline<br>Adductor-Canal-Block, Placebo (30 mL Saline). Ultrasound-guided application. 36 patients. | Procedure: Adductor Canal Block, Placebo (saline)<br>* Ultrasound-guided Adductor Canal Block; 30 mL Saline. Single dose.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain-Score (VAS) - patient standing | Pain-score messured on a Visual Analog Scale (VAS) 2 hours after adductor canal block. Patient standing. Intervention-group vs. placebo-group. | 2 hours postoperative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain-score (VAS), patient at rest | ACB-group vs. placebo | 0,1,2,4,6,8,24 hours postoperative | 
| Pain-score (VAS), patient standing | ACB-group vs. placebo | 1,2,4,6,8,24 hours postoperative | 
| Pain-score (VAS), after 5 meters of walk | ACB-group vs. placebo | 2,4,6,8,24 hours postoperative | 
| Total Opioid-consumption | ACB-group vs. placebo-group | 0-24 hours postoperative | 
| Opioid-consumption, postoperative | i.v. morfin 0-2 hours postoperative tbl. morfin 2-24 hours postoperative ACB vs. placebo | 0-2, 2-4, 4-6, 6-8, 8-24 hours postoperative | 
| Postoperative Nausea and vomiting | Rating-scale 0-3 ACB-group vs. placebo-group | 0-1, 1-2, 2-4, 4-6, 6-8, 8-24 hours postoperative | 
| Postoperative ondansetron consumption | ACB-group vs. placebo-group | In-hospital | 
| Sedation | Rating-scale: 0-3 ACB-group vs. placebo-group | 0,1,2,4,6,8,24 hours postoperative | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Adductor Canal Block (ACB), Diagnostic Knee Arthroscopy, Saphenous nerve, Pain, Ultrasound block