Emotion and Motivation in Patients With Psychosis

Study Overview
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Brief Summary
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Anhedonia and avolition reflect emotional and motivational disorders, respectively. However, if these disorders play a major role in the symptomatology of schizophrenia, their mechanisms remain poorly understood, and existing treatments are inefficient on these symptoms. The literature suggests that the impairment does not concern emotion or motivation per se, but rather their influence on cognition. This project aims at using recent advances in the fundamental domain to better understand the cognitive and neuronal mechanisms of the patients' alterations, and especially how emotion and motivation influence cognition in schizophrenia.

Official Title
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Influence of Emotion and Motivation on Behaviour and Neural Activity in Patients With Psychosis

Conditions
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Schizophrenia

Intervention / Treatment
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* Other: Electroencephalogram
* Behavioral: Cognitive tasks
* Behavioral: subjective evaluation scales


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: diagnostic and Statistical Manual of Mental Disorders criteria for schizophrenia Exclusion Criteria: addiction problem invalidating visual sensory problems neurological history for the healthy volunteers: psychiatric history

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sham Comparator: Healthy volunteers<br>Healthy volunteers | Other: Electroencephalogram<br>* electrophysiological measurements (evoked potentials) based on neural activity when visualizing stimuli<br>Behavioral: Cognitive tasks<br>* - clinical scales and subjective assessments of emotional and motivational stimuli<br>Behavioral: subjective evaluation scales<br>* - clinical scales and subjective assessments of emotional and motivational stimuli<br>|
| Experimental: Patients with schizophrenia<br>Patients with schizophrenia | Other: Electroencephalogram<br>* electrophysiological measurements (evoked potentials) based on neural activity when visualizing stimuli<br>Behavioral: Cognitive tasks<br>* - clinical scales and subjective assessments of emotional and motivational stimuli<br>Behavioral: subjective evaluation scales<br>* - clinical scales and subjective assessments of emotional and motivational stimuli<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in the amplitude of the CNV (Contingent Negative Variation) as a function of the primer displayed on the screen | Before each cognitive trial a primer will be displayed, which will be either neutral or convey emotion or motivation. The investigators will check whether this primer affects the subjects preparation by measuring the CNV, which is an evoked potential recorded with electroencephalography, and indexing preparatory effort. | During EEG sessions, at experimental session 1 (Day 0) and experimental session 2 (up to Day 120) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in the amplitude of the LPP (Late Positive Potential) as a function of the primer displayed on the screen | The investigators will check whether primers affect the subjects attention by measuring the LPP, which is an evoked potential recorded with electroencephalography, and indexing sustained attention. | During EEG sessions, at experimental session 1 (Day 0) and experimental session 2 (up to Day 120) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Emotion, motivation, cognition, schizophrenia