Prism Adaptation Therapy for Spatial Neglect

Study Overview
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Brief Summary
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The purpose of this research study with a randomized controlled design is to examine the effects of prism adaptation treatment on two visual-spatial recovery components. After a stroke, an internal GPS, locating where objects or people lie in a particular area of space, may be impaired. Alternately, a stroke may impair precise visual-spatial hand and body aiming movements. The research team wishes to discover whether prism adaptation treatment (two weeks of daily 20-min sessions of goal-directed movement with prism goggles) affects visual-spatial where or aiming errors selectively after stroke. This research represents one of the first attempts to apply what we know about the brain from neuroscience research, to modern clinical rehabilitation practices.

Detailed Description
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The purpose of this research study with a randomized controlled design is to examine the effects of prism adaptation treatment on two visual-spatial recovery components. After a stroke, an internal GPS, locating where objects or people lie in a particular area of space, may be impaired. Alternately, a stroke may impair precise visual-spatial hand and body aiming movements. The research team wishes to discover whether prism adaptation treatment (two weeks of daily 20-min sessions of goal-directed movement with prism goggles) affects visual-spatial where or aiming errors selectively after stroke. This research represents one of the first attempts to apply what we know about the brain from neuroscience research, to modern clinical rehabilitation practices.

Official Title
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Prism Adaptation Therapy for Spatial Neglect: Theoretical and Practical Outcomes

Conditions
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Spatial Neglect, Deficits in Attention Motor Control and Perception

Intervention / Treatment
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* Behavioral: Prism Adaptation Treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The subject is 18 to 100 years of age, inclusive. The subject has had a stroke on the right side of the brain. The subject is able to give Informed consent. The subject has a spatial neglect (if known). The subject is able and willing to comply with the study protocol, including availability for all scheduled clinic visits. Exclusion Criteria: The subject has or had a serious brain condition other than stroke.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Prism Adaptation Treatment<br>Two weeks of prism adaptation treatment followed by 4 weekly assessments and long-term follow-ups at the 3rd and 6th months. | Behavioral: Prism Adaptation Treatment<br>* Wearing prism goggles and performing visuomotor tasks during therapy sessions.<br>|
| No Intervention: Control: Standard Rehabilitation Care<br>Participants will continue with their standard inpatient rehabilitation care. They will be assessed with cognitive and functional scales for tracking their recovery. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Kessler Foundation Neglect Assessment Process | a performance based and behavioral measure for spatial neglect that utilizes and standardizes the administration of the Catherine Bergego Scale (CBS) | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Behavior Inattention Test | Conventional subtest, a set of paper and pencil test for spatial neglect | 2 weeks | 
| Barthel Index | A functional independence assessment of daily tasks | 2 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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stroke, CVA, cerebrovascular accident, rehabilitation