Doppler Sonography, MR Venography, Plethysmography for the Diagnosis of CCSVI

Study Overview
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Brief Summary
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This study is aimed at evaluation of diagnostic value of Doppler sonography, MR venography and air-plethysmography for the assessment of abnormalities in the internal jugular veins, with catheter venography as the reference test.

Official Title
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Doppler Sonography, Magnetic Resonance Venography, Air-plethysmography in the Non-invasive Diagnostics of Chronic Cerebrospinal Venous Insufficiency (CCSVI)

Conditions
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Chronic Cerebrospinal Venous Insufficiency

Intervention / Treatment
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* Other: Doppler sonography of internal jugular veins
* Other: Magnetic resonance venography of internal jugular veins
* Other: Air-plethysmography of the neck
* Other: Catheter venography of internal jugular veins


Participation Criteria
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Eligibility Criteria
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Patients group Inclusion Criteria: confirmed diagnosis of multiple sclerosis Exclusion Criteria: coexisting another neurologic pathology (e.g. stroke, Parkinson disease) significant stenosis of carotid or vertebral arteries other significant abnormalities of blood vessels of the upper part of the body tricuspid valve incompetence allergy to iodine contrast dye chronic renal failure pregnancy other severe comorbidities or significant abnormalities in standard lab tests Healthy volunteers. Inclusion Criteria: none Exclusion Criteria: confirmed diagnosis of multiple sclerosis or related pathologies (CIS, NMO) coexisting another neurologic pathology (e.g. stroke, Parkinson disease) significant stenosis of carotid or vertebral arteries other significant abnormalities of blood vessels of the upper part of the body tricuspid valve incompetence

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Diagnostic study<br> | Other: Doppler sonography of internal jugular veins<br>* Doppler sonography of internal jugular veins<br>Other: Magnetic resonance venography of internal jugular veins<br>* Magnetic resonance venography of internal jugular veins<br>Other: Air-plethysmography of the neck<br>* Air-plethysmography of the neck<br>Other: Catheter venography of internal jugular veins<br>* Catheter venography of internal jugular veins<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Positive and negative predictive value of Doppler sonography, MR venography and air-plethysmography | Positive and negative predictive value of Doppler sonography,MR venography and air-plethysmography for the detecting of vascular malformation in the internal jugular veins with catheter venography as the reference test | All non-invasive test are done up to 14 days prior to catheter venography | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Vascular malformations in the internal jugular veins