Efficacy of Escitalopram in the Treatment of Internet Addiction

Study Overview
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Brief Summary
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The purpose of this study was to determine whether Lexapro (Escitalopram) is safe and effective in treating problematic internet use.

Detailed Description
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Many individuals experience marked distress and functional impairments as a result of their perceived inability to control their 'non-essential' (non-job/school related) use of the Internet. Frequently these people develop a preoccupation with the Internet, a need for escape to the Internet, and increasing irritability when trying to cut back use of the Internet. There have been no studies to date looking at the effectiveness of medications in the treatment of this disorder. In our clinical experience, we find these patients with Internet addiction usually respond to serotonin reuptake inhibitors within 12 weeks. This study will examine the efficacy of escitalopram in Internet addiction among adults.

Official Title
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Efficacy of Escitalopram in the Treatment of Internet Addiction

Conditions
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Internet Addiction

Intervention / Treatment
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* Drug: Escitalopram


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subject has signed an informed consent form Current diagnosis of Internet addiction Age ³ 18 Subject must be able to take oral medication Subject may be in psychotherapy initiated at least three months prior to Screening. Subject must not discontinue or otherwise alter this therapy during the study. In the opinion of the investigator, the subject is capable of complying with all study procedures. Exclusion Criteria: Current suicidal or homicidal ideation Subject has a primary diagnosis of schizophrenia or other psychotic disorders Subject has a primary diagnosis of Bipolar I disorder Current pedophilia Current DSM-IV diagnosis of substance dependence or abuse, excluding nicotine Women of child-bearing potential who are pregnant, nursing, or not using contraception Use of antidepressants at a therapeutic level for the treatment of problematic internet use within 2 weeks prior to study entry (or 4 weeks for use of MAOIs, or 6 weeks for use of fluoxetine) Current use of antidepressants at a therapeutic level for the treatment of a disorder other than problematic internet use Subject has any organic mental disorder Clinically significant unstable medical disorder

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Single Arm<br>Escitalopram | Drug: Escitalopram<br>* 10 mg/day<br>* Other names: Lexapro;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| length of non-essential Internet use in hours/week as well as CGI-Improvement |  | baseline and biweekly for 10 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ratings on depression, anxiety, impulsivity, self-esteem, obsessive-compulsive symptoms |  | baseline and biweekly for 10 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Internet addiction, Problematic internet use, Escitalopram, Lexapro