Brain Perfusion and Hemodynamic Stability in Patients Undergoing Radiofrequency Ablation of Ventricular Tachycardia

Study Overview
=================
Brief Summary
-----------------
Ventricular tachycardia (VT) is a life-threatening, fast heart rhythm that starts in the lower chambers of the heart (the ventricles). This fast heartbeat is caused by abnormal electrical pathways located in the heart tissue. A standard procedure called a catheter ablation has been used for several years to help correct these abnormal pathways and, in some cases, improve or even eliminate the ventricular tachycardia. During a VT ablation it is routine to monitor your vital signs (blood pressure, heart rate, and oxygen saturation in your blood). If you choose to participate in this study we will also monitor your cerebral oximetry, the amount of blood flow and oxygen saturation to your brain during the ablation. By doing this study, we hope to have a better understanding of patients' blood and oxygen flow to their brain during an episode of Ventricular Tachycardia (VT).

Official Title
-----------------
Assessment of Intracardiac and Surgace Electrogram Characteristics Correlated to Brain Perfusion and Hemodynamic Stability in Patients Undergoing Radiofrequency Ablation of Ventricular Tachycardia

Conditions
-----------------
Ventricular Tachycardia

Intervention / Treatment
-----------------
* Other: Data Collection Forms


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Able to give informed consent Have implantable defibrillator in-situ and are undergoing ablation procedure for ventricular tachycardia Exclusion Criteria: Patients who have been hypotensive with systolic blood pressure of < 80mm Hg prior to procedure Cerebral event as defined by Cerebrovascular Accident or Transient Ischemia Attack within six months prior to procedure

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Ventricular Tachycardia<br>Participants in cohort will have implantable defibrillators in-situ and are undergoing ablation procedure for ventricular tachycardia. | Other: Data Collection Forms<br>* Participants will be asked questions relating to pre-procedure items and be asked to complete an MMSE. Subjects receive standard of care surgery. Data collected from procedures before, during and after surgery.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Identify clinical, EKG and EGM characteristics of hemodynamically unstable VT | The investigator will be evaluating the relationship of the oxygenation level of the brain during a Ventricular Tachycardia ablation. | Change from Baseline to 24-48 hours after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MMSE to determine cerebral function before and after VT ablation | The use of the Mini-Mental Status Exam prior to the ablation will serve as a reference point and will be repeated 24 hours post exam. | 24 hours after surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Radiofrequency ablation, fast heart rhythm, ventricle, catheter ablation, ablation