Effects of Head Elevation on Intracranial Pressure in Children

Study Overview
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Brief Summary
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Head injury is the most common cause of mortality and acquired disability in childhood. It is common to elevate the head of patients at risk for increased intracranial pressure, although it is not clear if it is always beneficial. Every severe pediatric traumatic brain injured patient will have an optimal head position that prevents rising pressure in the brain.

Detailed Description
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Head injury is the most common cause of mortality and acquired disability on childhood. Management of children at risk for intracranial hypertension is both complex and increasingly controversial. Also, effect of head position on intracranial pressure, cerebral perfusion pressure, adn cerebral venous outflow in the pediatric population has not been studied. We will examine the effect of head positioning on ICP, CPP, and cerebral venous outflow in pediatric patients at risk for intracranial hypertension. The hypothesis is that ICP will be reduced with improvement in cerebral venous outflow by each patient having their own optimal head position.

Official Title
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Effect of Head Elevation on Intracranial Pressure and Cerebral Venous Outflow in Children

Conditions
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Head Injury

Intervention / Treatment
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* Procedure: Place HOB in alternate positions from 0-50 degrees.


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Neonates, children, and adolescents Intracranial pressure monitor in place Exclusion Criteria: Severe multiorgan system failure Hemodynamic instability sufficient to preclude changes in head position

Ages Eligible for Study
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Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Single arm--no randomization. All subjects enrolled will have vitals collected and three ultrasounds at different levels of head of the bed elevations. | Procedure: Place HOB in alternate positions from 0-50 degrees.<br>* Patients will receive an US while the HOB(Elevation of the head of bed) is 30 degrees(baseline) then they will increase the angle to 40 degrees, then 50 degrees. Another US will be done then in 20, 10, and o degree angles. Then another US will be done<br>* Other names: Head injury;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ICP will be reduced with improvement in cerebral venous outflow which is dependent on intravascular volume status and intrathoracic pressure and each will have their own optimal head position. |  | As long as ICP is being monitored. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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elevated intracranial pressure, inadequate cerebral perfusion, secondary brain damage