Cardiovascular Protective Role of Laser Acupuncture in Systemic Lupus

Study Overview
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Brief Summary
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Systemic lupus erythematosus is a chronic and multisystemic autoimmune disorder which predominantly affecting women. The most common cause of death in lupus patients affected by disease for more than 5 years is cardiovascular disease due to presence of some factors as oxidative stress, pro-inflammatory cytokines , dyslipidemia, diabetes, and hypertension.

Detailed Description
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laser acupuncture (active or sham) for one month (3 days/week ) on acupoint number 14 of GV meridian, acupoint number 4 and 11 of large intestine, acupoint number 34 of gall bladder meridian, acupoint number 3 of liver meridian, acupoint number 4, 12, and 9 of conception vessel meridian, acupoint number 40, 36, and 25 of stomach meridian, acupoint number 6 of spleen meridian, and acupoint number 5 of triple energizer meridian (laser will be applied for 1 min on every acupiont) in lupus females

Official Title
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Cardiovascular Protective Role of Laser Acupuncture in Systemic Lupus

Conditions
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System; Lupus Erythematosus

Intervention / Treatment
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* Device: laser application on acupoints


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: lupus females 60 patients Exclusion Criteria: pregnancy cardiovascular diseases respiratory diseases

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 47 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: group 1<br>thirty lupus women received laser acupuncture (active) for one month (3 days week) on acupoint number 14 of GV meridian, acupoint number 4 and 11 of large intestine, acupoint number 34 of gall bladder meridian, acupoint number 3 of liver meridian, acupoint number 4, 12, and 9 of conception vessel meridian, acupoint number 40, 36, and 25 of stomach meridian, acupoint number 6 of spleen meridian, and acupoint number 5 of triple energizer meridian (laser was applied for 1 min on every acupiont). | Device: laser application on acupoints<br>* laser acupuncture<br>|
| Sham Comparator: group 2<br>thirty lupus women received laser acupuncture (sham) for one month (3 days) on acupoint number 14 of GV meridian, acupoint number 4 and 11 of large intestine, acupoint number 34 of gall bladder meridian, acupoint number 3 of liver meridian, acupoint number 4, 12, and 9 of conception vessel meridian, acupoint number 40, 36, and 25 of stomach meridian, acupoint number 6 of spleen meridian, and acupoint number 5 of triple energizer meridian (laser was be applied for 1 min on every acupiont). | Device: laser application on acupoints<br>* laser acupuncture<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Malondialdehyde | anti-oxidative stress factor | It was measured after 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| systole | blood pressure | It was measured after 4 weeks | 
| diastole | blood pressure | It was measured after 4 weeks | 
| blood glucose | fasting | It was be measured after 4 weeks | 
| erythrocyte sedimentation rate (1 hour) | inflammatory marker | It was measured after 4 weeks | 
| erythrocyte sedimentation rate (2 hour) | inflammatory marker | It was measured after 4 weeks | 
| c reactive protein | inflammatory marker | It was measured after 4 weeks | 
| adenosine triphosphate | energy production marker | It was measured after 4 weeks | 
| Nitrate | oxidative stress factor | It was measured after 4 weeks | 
| Glutathione | antioxidant marker | It was measured after 4 weeks |