Development of Frailty Prevention Clinic in Geriatric Comprehensive Clinic RSCM:

Study Overview
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Brief Summary
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There is an increasing number of elderly population, not only in Indonesia, but also in the world. With increasing of age, there is also an increasing number of elderly with sarcopenia and frailty. Both of the diseases can lead to dependency, decrease quality of life, and morbidity. Besides nutrition, physical activity, especially resistance training is proven to be beneficial in improving sarcopenia and frailty condition. Currently in Cipto Mangunkusumo National Hospital (RSCM), there is no comprehensive frailty prevention clinic in the geriatric inpatient clinics. This research can be the base of frailty and sarcopenia treatment in RSCM.

Official Title
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Development of Frailty Prevention Clinic in Geriatric Comprehensive Clinic RSCM: The Role of Resistance Training as Sarcopenia and Frailty Management Towards Frailty Score, Sarcopenia Score, and Quality of Life

Conditions
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Frailty, Sarcopenia, Resistance Training

Intervention / Treatment
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* Procedure: Resistance Training
* Procedure: Standard Therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients 60 years old or orlder Categorized as Pre-frail or Frail based on FRAIL criteria Is not in routine physical activity in the past 3 months Succeeded Mini Physical Performance Test with score 11 or more Exclusion Criteria: Cognitive Disturbance (Abbreviated Mental Test < 8) Not consenting to join the trial

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Control<br>12-week of Standard Therapy using elastic-band | Procedure: Standard Therapy<br>* Standard therapy for 12 weeks<br>|
| Experimental: Intervention<br>12-week of Resistance Training developed by RSCM using sand-bag | Procedure: Resistance Training<br>* Resistance training developed by the researcher (SCR-RSCM) for 12 weeks<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Frailty Status | The FRAIL scale includes 5 components: Fatigue, Resistance, Ambulation, Illness, and Loss of weight (10). Frail scale scores range from 0-5 (i.e., 1 point for each component; 0=best to 5=worst) and represent frail (3-5), pre-frail (1-2), and robust (0) health status | 12 weeks | 
| Sarcopenia Status | Measured using: BIA: <7.0 kg/m2 in men and <5.7 kg/m2 in women Five times sit to stand: ≥12 seconds Hand-grip strength: <28 kg for men and <18 kg for women | 12 weeks | 
| Walking Speed | <1.0 m/s | 12 weeks | 
| Patient's Quality of Life | Measured by EQ-5D: ranging from 0 ('worst imaginable health') to 100 ('best imaginable health') | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of Frailty | The FRAIL scale includes 5 components: Fatigue, Resistance, Ambulation, Illness, and Loss of weight (10). Frail scale scores range from 0-5 (i.e., 1 point for each component; 0=best to 5=worst) and represent frail (3-5), pre-frail (1-2), and robust (0) health status | 12 weeks | 
| Prevalence of Sarcopenia | Measured using: BIA: <7.0 kg/m2 in men and <5.7 kg/m2 in women Five times sit to stand: ≥12 seconds Hand-grip strength: <28 kg for men and <18 kg for women | 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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elderly, frailty, sarcopenia, resistance training