Respiratory Training in Patients With Leukemia

Study Overview
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Brief Summary
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Forty male leukemic patients receiving chemotherapy were selected from National Cancer Institute, They were randomly assigned into two groups. Group (A) included 30 patients who were trained by Inspiratory muscle trainer for 4 weeks ;5 sessions/week and Group (B) included 10 patients as a control group. The following measures were taken before and after the study period : Maximum voluntary ventilation(MVV) , 2 min walk test, FACT-G questionnaire

Detailed Description
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Forty male leukemic patients receiving chemotherapy for at least one cycle and their mean ages 37.1 ± 4.89 years.The patients were selected from National Cancer Institute, Cairo ( inpatient ward). The study lasted from March 2018 to June 2018. Patients were randomly assigned into two groups.Group A (30 patients) who received inspiratory muscles training for 4 successive weeks, 5 sessions/week; and Group B (10 patients) acted as a control group on chemotherapy only. Data obtained from both groups regarding (MVV), 2 min walk test and Quality of life questionnaire (FACT-G) were statistically analyzed and compared

Official Title
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Influence of Respiratory Training on Functional Capacity in Patients With Leukemia

Conditions
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Leukemia

Intervention / Treatment
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* Other: respiratory training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: male patient with age ranges from 30-50 years All patients were leukemic receiving chemotherapy for at least one cycle as a treatment of malignant tumor All patients were hemodynamically stable All patients were ambulant Exclusion Criteria: lung cancer History of any pulmonary disease. Metastasis of lungs, ribs, mediastinal structure Pulmonary pathology(e.g acute respiratory distress syndrome or exacerbation of chronic obstructive pulmonary disease) ruptured ear drum or any other condition of the ear High peak airway pressure (barotraumas) patients with marked elevated left ventricular end diastolic volume and pressure patients with worsening heart failure signs and symptoms

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: study group (group A)<br>Group (A) included 30 leukemic patients receiving chemotherapy in addition to training by inspiratory muscle trainer(IMT) for 4 weeks, 5 sessions /week | Other: respiratory training<br>* Respiratory training was done by using threshold inspiratory muscle trainer(Respironics, New Jersey , USA, No.8373-0730)<br>|
| No Intervention: control group (B)<br>Group (B) included 10 leukemic patients receiving chemotherapy only | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximum voluntary ventilation | It was performed by breathing deeply and rapidly for 10 to 15 seconds using spirometer | change from baseline maximum voluntary ventilation at 4 weeks | 
| 2 min walk test | Each patient was asked to cover as much ground as possible over 2 minutes | change from baseline 2 min walk test at 4 weeks | 
| FACT-G questionnaire | 27 questions with four domains assessing physical well being,social well being, emotional well being and functional wellbeing | change from baseline FACT-G questionnaire at 4 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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leukemia, chemotherapy, respiratory training