Interval Training Study in Psoriatic Arthritis

Study Overview
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Brief Summary
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Psoriatic arthritis is a chronical inflammatory disease characterized by pain and reduced physical function. Patients have a higher risk of cardiovascular disease and a higher body mass index. A pilot study in patients with rheumatoid arthritis has shown positive effect on inflammation after 12 weeks of high-intensity interval training. The primary aim of this study is to determine whether high-intensity interval training affects the disease activity in psoriatic arthritis. This intervention is believed to result in benefits in terms of inflammation, body composition and risk factors for cardiovascular disease.

Official Title
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Interval Training Study in Psoriatic Arthritis

Conditions
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Psoriatic Arthritis

Intervention / Treatment
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* Behavioral: interval training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: fulfilling the CASPAR criteria of psoriatic arthritis ability to exercise. Exclusion Criteria: Inability to exercise very high disease Activity unstable ischemic cardiovascular disease severe pulmonary disease pregnancy breastfeeding drug- and alcohol addictions

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: interval training<br>4x4 high intensity interval training was performed on a stationary bicycle with a supervisor twice a week and by one self-training a week. | Behavioral: interval training<br>* 4x4 high intensity interval training<br>|
| No Intervention: controls<br>No change in diet and training habits | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient global assesment (PGA) | PGA is measured as a change between timepoints. PGA is registered by the patient on a visual analog scale. | Baseline, 3 months (right after intervention), 9 months | 
| Maximal oxygen uptake (VO2 max) | The VO2 max is measured as a change between timepoints | Baseline, 3 months (right after intervention), 9 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total lean mass | Total lean mass is measured as a change between timepoints and is measured by dual energy x-ray absorptiometry (DXA). | Baseline, 3 months (right after intervention), 9 months | 
| Total body fat | Total body fat is measured as a change between timepoints and is measured by dual energy x-ray absorptiometry (DXA). | Baseline, 3 months (right after intervention), 9 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Exercise Therapy