High Intensity Interval Training or Strength Training in Women With Polycystic Ovary Syndrome

Study Overview
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Brief Summary
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The aim is to investigate whether strength training or high intensity interval training is effective in improving insulin sensitivity, cardiovascular outcomes, body composition and reproductive outcomes in women with Polycystic Ovary Syndrome (PCOS). Few studies have examined the effect of strength training alone on insulin sensitivity, reproductive outcomes and body composition in women with PCOS. Most previous studies on aerobic exercise in PCOS have applied moderate exercise intensity.

Official Title
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High Intensity Interval Training or Strength Training in Women With Polycystic Ovary Syndrome. A Randomized Controlled Trial

Conditions
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Polycystic Ovary Syndrome

Intervention / Treatment
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* Behavioral: strength training
* Behavioral: interval training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Women Age 18-45 years old PCOS Exclusion Criteria: Regular high intensity endurance or strength training (two or more times per week of vigorous exercise). Concurrent treatments (insulin sensitizers or drugs known to affect gonadotropin or ovulation, with a wash out period of 1 months prior to inclusion). On-going pregnancy.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: strength training<br>The subjects will attend for supervised training three sessions per week for 10 weeks (9-12). The strength training program involves dynamic contraction at intensities of 60 - 70 % of 1 repetition maximum (RM) to improve strength and muscle hypertrophy. Each session will contain 8 exercises on the major muscle groups. Each drill consists of 10-12 repetitions (reps) x 3 sets separated by one minute rest between sets. | Behavioral: strength training<br> <br> * Other names: resistance training;|
| Experimental: interval training<br>High intensity interval training (HIT) three times per week. The three weekly supervised HIT sessions will include two 4x4 min interval sessions and one 10x1 min session. The HIT consist of uphill treadmill running/walking. | Behavioral: interval training<br> <br> * Other names: aerobic exercise;|
| No Intervention: control<br>Based on the Norwegian recommendation we will encourage the control group to perform 60 minutes of physical activity at moderate to high intensity on a daily basis. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| insulin resistance | measured with the homeostatic model assessment for insulin resistance (HOMA-IR) method | 10 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body composition | Measured as body fat % on an impedance scale and waist circumference | 10 weeks | 
| Maximum oxygen uptake | Measured during maximum effort exercise test | 10 weeks | 
| Endothelial function | Flow mediated dilatation of the brachial artery. | 10 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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exercise, resistance training, insulin resistance, high intensity interval training