Super-resolution of Brain Magnetic Resonance Images in Deep Brain Stimulation for Parkinson's Disease

Study Overview
=================
Brief Summary
-----------------
The goal of this study is to increase magnetic resonance image quality in patients suffering from Parkinson's disease. The main question it aims to answer is: can super-resolution improve clinical magnetic resonance image quality to benefit deep brain stimulation for Parkinson's disease? Participants will receive an additional high-quality MRI scan.

Detailed Description
-----------------
Rationale: Better targeting of the subthalamic nucleus (STN) improves the outcome of deep brain stimulation (DBS) for Parkinson's disease. Yet, the accuracy of delineating the STN, and therefore the targeting, is limited by the spatial resolution of the magnetic resonance (MR) imaging. The current study aims to acquire a high resolution (HR) MR dataset, tailored to visualise the STN, to train a super-resolution model to predict HR MR images based on lower resolution MR input. This model will aid delineating the STN and improve segmentation and targeting. Objective: To develop a deep learned super-resolution model that predicts high-resolution MR images with a peak signal-to-noise ratio of 37dB or higher. Study design: Prospective observational study. Study population: Twenty Parkinson's patients considered eligible for DBS surgery at Radboudumc will be included. Main study parameters/endpoints: Peak signal-to-noise ratio measured in decibels.

Official Title
-----------------
Super-resolution of Brain Magnetic Resonance Images in Deep Brain Stimulation for Parkinson's Disease

Conditions
-----------------
Parkinson Disease, Parkinson

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients eligible for bilateral STN-DBS-surgery for Parkinson's disease. Signed informed consent Exclusion Criteria: Any intracranial abnormality that is not in line with Parkinson's disease progression Previous intracranial surgery Any significant medical condition that is likely to interfere with study procedures. Pregnancy at the time of enrollment. Participation in any other clinical trial (e.g. drug, device, or biologics) that interferes with this study.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Peak signal-to-noise ratio | The change in image quality as determined by the peak signal-to-noise ratio. | Six months after study completion of the last subject. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Structural similarity index measure | The change in image quality as determined by the structural similarity index measure. | Six months after study completion of the last subject. | 
| Normalized root mean squared error | The change in image quality as determined by the normalized root mean squared error. | Six months after study completion of the last subject. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
MRI, Magnetic Resonance Imaging, Super Resolution