EAST-west Colorectal Study

Study Overview
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Brief Summary
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Colorectal resection due to benign and malignant diseases is a commonly performed procedure. The continuity of the gastrointestinal tract is re-established by creating an anastomosis. Although such procedures are often performed, anastomotic techniques and postoperative outcomes usually vary. Failure of the anastomosis might be a life-threatening condition after colorectal resection. A relatively high incidence of anastomotic leaks (up to 30%) has been reported worldwide. Anastomotic failure could happen due to several reasons, that are divided into surgeon-related factors and patient-related factors. So far, there has been no data about the incidence of anastomotic leak in the Western Balkans and the Mediterranean countries.The aim of EAST-WEST Colorectal Study 2022 is to investigate differences in patients undergoing colorectal resections, including pre-operative patient preparation, history of prior surgeries and anastomotic techniques. In addition, this study aims to collect data about post-operative complication rate within 30 days post-surgery across Balkan countries (Slovenia, Serbia, Macedonia, Croatia, BIH and Monte Negro), Greece, Romania and Malta, hence the study outcomes could be applicable to the Mediterranean region, in which patients share a common set of characteristics. This would enable variabilities in practice to be identified and differences regarding postoperative outcomes to be highlighted.

Official Title
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The Effect of Preoperative Factors and Surgical Technique on Postoperative Outcomes in Patients Undergoing Colorectal Resections at South-eastern Europe.

Conditions
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Colorectal Anastomosis

Intervention / Treatment
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* Procedure: Colorectal Anastomosis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adults between 18-90 years old undergoing colorectal resection with anastomosis due to benign and malignant diseases Any of the procedures listed below performed as an emergency or elective surgery, and by any approach; open, laparoscopic or robotic: Right hemicolectomy and extended right hemicolectomy Ileocecal resection Transverse colon resection Segmental colonic resection - i.e. splenic resection Left hemicolectomy Sigmoid resection Rectal resection Pan-proctocolectomy Exclusion Criteria: Closure of ileostomy or colostomy Creation of multiple anastomoses Small bowel resection Pelvic exenteration Cytoreductive surgery

Ages Eligible for Study
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Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Colorectal Anastomosis|Differences in intra-operative techniques and surgeon grades|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Leakage rate |  | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Re-admission rate within the first 30 days post-surgery. |  | 30 days | 
| 30-day postoperative morbidity |  | 30 days | 
| 30-day postoperative mortality |  | 30 days | 
| Clavien-Dindo complication classification |  | 30 days | 
| Length of stay |  | 30 days |