Cognitive Intervention in Mild Cognitive Impairment With or Without White Matter Hyperintensities

Study Overview
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Brief Summary
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This is a non-pharmacological study evaluating the differential effects of a computerized cognitive stimulation program according to the existence or not of white matter hyperintensities in elderly with mild cognitive impairment.

Detailed Description
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White matter hyperintensities (WMH) are increasingly recognized as a factor determining the heterogeneity of Mild Cognitive Impairment (MCI) and have been associated to executive and processing speed impairment. Cognitive interventions in MCI remain quite limited for these MCI with vascular profile and studies often distinguish patients by clinical subtypes rather than brain profile before an intervention. Considering magnetic resonance imaging (MRI) data, this study investigated the effects of a computer-based cognitive stimulation (CCS) program on MCI with WMH compared to MCI without WMH.

Official Title
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Evaluation of Differential Effects of a Computer-based-cognitive Intervention on Cognition Among Elderly With Mild Cognitive Impairment With and Without White Matter Hyperintensities: A Comparative Study.

Conditions
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Mild Cognitive Impairment

Intervention / Treatment
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* Behavioral: Computerized Cognitive Stimulation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical diagnosis of Mild Cognitive Impairment With and without white matter hyperintensities MRI available or accept to perform one No engagement in other cognitive intervention program Exclusion Criteria: Psychiatric and neurological disorders History of alcohol or other substance abuse Sensory and/or motor deficit affecting the use of a tablet

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Comparison, non-randomized single blind study
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: MCI with WMH<br>Computerized Cognitive Stimulation was administered to this group, twice a week. | Behavioral: Computerized Cognitive Stimulation<br>* All participants performed 12-week, 60-minutes twice a week of a computer-based cognitive stimulation program in group-setting, using a tablet with a software with specific training focused on attention, executive and speed processing functions.<br>|
| Active Comparator: MCI without WMH<br>Computerized Cognitive Stimulation was administered to this group, twice a week. | Behavioral: Computerized Cognitive Stimulation<br>* All participants performed 12-week, 60-minutes twice a week of a computer-based cognitive stimulation program in group-setting, using a tablet with a software with specific training focused on attention, executive and speed processing functions.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rey Auditory Verbal Learning test | Assessment of verbal learning in episodic memory | Baseline assessment, change from Baseline on Rey Auditory Verbal Learning test at 3 months immediately after intervention and at 3 months follow-up |