NLCR in Prediction of the Grade of Lung Tumor.

Study Overview
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Brief Summary
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The aim of the study is to assess whether the value of neutrophil-lymphocyte count ratio from the routine preoperative blood test may predict lung tumors' grading.

Detailed Description
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Lung cancer remains as one of the leading causes of death among oncology patients. Close connection between inflammation and pathogenesis of some neoplasms was determined in a number of studies. Some studies show promise that ratio of neutrophil to lymphocyte count (NLCR) may be recognized as a prognostic marker for several carcinomas: renal, lung and colorectal. The aim of the study is to assess whether the value of neutrophil-lymphocyte count ratio from the routine preoperative blood test may predict lung tumors' grading. During routine preoperative blood tests complete blood count is done and NLCR, WBC, neutrophil and lymphocyte count is noted. After the thoracic surgery intervention and histopathological examination grading of lung tumor is noted.

Official Title
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Preoperative Neutrophil-lymphocyte Count Ratio in Prediction of the Grade of Lung Tumor.

Conditions
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Lung Neoplasm

Intervention / Treatment
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* Diagnostic Test: Complete blood count
* Other: Histopathological examination


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: consecutive thoracic surgery patients with lung cancer grading confirmed by histopathology postoperatively preoperative routine complete blood count analysis Exclusion Criteria: infectious disease pregnancy autoimmunologic disease other known conditions or treatments that may influence the blood count (seropositivity for HIV, chemotherapy, and corticotherapy)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Observational Group<br>Group of patients with lung tumor qualified for thoracic surgery intervention with routine, preoperative complete blood count test and routine postoperative histopathological examination of lung tumor. | Diagnostic Test: Complete blood count<br>* During routine preoperative blood test complete blood count is taken.<br>Other: Histopathological examination<br>* Routine postoperative histopathological examination of lung tumor.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neutrophil-lymphocyte count ratio | Neutrophil-lymphocyte count ratio is measured during routine preoperative blood tests. | From October 1, 2014 to October 15, 2018 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neutrophil count | Neutrophil count is measured during routine preoperative blood tests. | From October 1, 2014 to October 15, 2018 | 
| Lymphocyte count | Lymphocyte count is measured during routine preoperative blood tests. | From October 1, 2014 to October 15, 2018 | 
| Leucocyte count | Leucocyte count is measured during routine preoperative blood tests. | From October 1, 2014 to October 15, 2018 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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NLCR, The neutrophil-lymphocyte count ratio, Lung Neoplasm