Quantifying the Deterioration of Physical Function in Renal Patients

Study Overview
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Brief Summary
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Patients undergoing haemodialysis present a decrease in physical function, but little is known about the rate at which function decreases. The purpose of this study is quantifying the nature and degree of functional deterioration experienced by stage 5 chronic kidney disease patients during a six month period of maintenance haemodialysis therapy.

Official Title
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Quantifying the Deterioration of Physical Function Along 6 Months in Patients in End Stage Renal Disease

Conditions
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End Stage Renal Disease

Intervention / Treatment
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* Other: Functional Test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: people under hemodialysis treatment at least 3 months be medicable stable complete all the physical tests Exclusion Criteria: heart stroke in the previous 6 weeks of the study inferior limb amputation without artificial aids cerebral vascular disease (ictus, ischemic) disability to complete functional tests

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Functional Test|Observation of physical function in hemodialysis patients during a period of 6 months|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from Baseline Short Physical Performance Battery at 6 months | Assess lower extremity, which includes objective performance-based measure of balance (side-by-side, semi-tanden and tandem), endurance (4m gait speed) and strength (five chair stands). Each component was scored from 0 to 4 and when summed yielded Short Physical Performance Battery scores between 0 (poor) and 12 (best). | At the beginning of the study and after 6 months | 
| Change from Baseline One Leg Standing Test at 6 months | Consist in maintain one leg stance for as long as possible. The test was considered normal if the one leg standing time reached 45 seconds. | At the beginning of the study and after 6 months | 
| Change from Baseline Timed Up and Go at 6 months | To stand up from a standard arms chair, walk 3 meters, turn back the cone walk back and sit down to the chair. The time in seconds is record. | At the beginning of the study and after 6 months | 
| Change from Baseline Sit to Stand to Sit 10 and 60 at 6 months | For the Sit To Stand 10 participant has to stand up and sit down 10 times and the time needed is record; while for the Sit to stand to sit 60 the participant consist in measures how many repetition the participant can to stand up and sit down during 60 seconds | At the beginning of the study and after 6 months | 
| Change from Baseline On leg heel rise at 6 months | It measures the strength in the triceps surae in the one leg standing position and has to rise the heel. It measures how many repetitions the participants is can do | At the beginning of the study and after 6 months | 
| Change from Baseline Handgrip strength at 6 months | To measure the amount of strength developed by each hand in kg | At the beginning of the study and after 6 months | 
| Change from Baseline Six Minutes Walking Time at 6 months | To walk the longest distance possible in 6 minutes by walking continuously the 20 or 30 metres indicated on the floor. It measures the distance in meters | At the beginning of the study and after 6 months |