Protein Expression in Tumor Tissue Samples From Patients With Cancer of the Oropharynx

Study Overview
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Brief Summary
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RATIONALE: Studying the proteins expressed in samples of tumor tissue from patients with cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors plan better treatment for patients with cancer of the oropharynx. PURPOSE: This laboratory study is looking at protein expression in tumor tissue samples from patients with cancer of the oropharynx.

Detailed Description
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OBJECTIVES: To investigate if some of the differences in gene expression are also reflected at the protein level. To determine whether differences in gene expression that are also reflected at the protein level can be used to develop markers for early detection and disease surveillance. To identify targets for therapy. OUTLINE: Archived tumor tissue samples are analyzed for expression of standard immunohistological markers (e.g., p16, p53, and Ki-67) as well as expression of genes identified in a previous gene expression study. Protein expression data are tested for clinical and demographic correlates and compared with gene expression data.

Official Title
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Protein Expression Profiles in Oropharyngeal Squamous Cell Carcinoma

Conditions
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Head and Neck Cancer

Intervention / Treatment
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* Genetic: gene expression analysis
* Genetic: microarray analysis
* Genetic: protein expression analysis
* Other: immunohistochemistry staining method
* Other: laboratory biomarker analysis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis of squamous cell carcinoma of the oropharynx Tumor tissue samples available from Vanderbilt Head and Neck Tumor Repository and Vanderbilt Pathology archives Exclusion Criteria: Not specified PRIOR CONCURRENT THERAPY: Not specified
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Genetic: gene expression analysis|profiles of HPV(+) and (-) HNSCCs|
|Genetic: microarray analysis|microarray analysis|
|Genetic: protein expression analysis|protein expression analysis|
|Other: immunohistochemistry staining method|immunohistochemistry staining method|
|Other: laboratory biomarker analysis|laboratory biomarker analysis|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Development of biomarkers for early detection or recurrence surveillance |  | after 7 months of tissue collection | 
| Identification of therapeutic targets and individualization of treatment based on the biology of squamous cell carcinoma of the oropharynx |  | after 7months of tissue collection | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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recurrent squamous cell carcinoma of the oropharynx, stage I squamous cell carcinoma of the oropharynx, stage II squamous cell carcinoma of the oropharynx, stage III squamous cell carcinoma of the oropharynx, stage IV squamous cell carcinoma of the oropharynx