Screening for Coronary Artery Disease After Mediastinal Irradiation

Study Overview
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Brief Summary
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Survivors of Hodgkin Lymphoma (HL) are known to have an increased risk of developing late treatment sequelae such as cardiovascular events due to coronary artery disease. At present no active screening is performed in these patients since it is not known whether screening and subsequent treatment by means of revascularization is effective in reducing the risk of cardiovascular events in symptomatic individuals. In the trial the efficacy and therapeutic consequences of screening for coronary artery diasease by multi-slice CT (MSCT) among asymptomatic HL survivors will be evaluated.

Detailed Description
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Objectives: to determine whether MSCT as a screening method of HL survivors treated with mediastinal irradiation accurately identifies asymptomatic significant coronary artery disease. to establish the prevelance of coronary abnormalities in HL survivors treated with mediastinal irradiation to determine the frequency and type of intervention to evaluate the acceptance of screening and asses quality of life among Hl survivors. Study polulation: 50 long term survivors of HL, previously treatef with mediastinal irradiation without present evidence of cardiovascular disease Intervention: CT-coronary angiography and calcium score, to be performed as a screening method (to indicate further diagnostic treatent procedures)

Official Title
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Screening for Coronary Artery Disease After Mediastinal Irradiation in Hodgkin Lymphoma Survivors

Conditions
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Radiation Therapy, Coronary Artery Disease, Hodgkin Lymphoma

Intervention / Treatment
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* Radiation: CT coronary angiography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: history of Hodgkin Lymphoma(all stages) with at least 10 disease free survival current age between 35-60 mediastinal irradiation as part of HL treatment, radiotherapy data available written informed consent Exclusion Criteria: current treatment for cardiovascualr disease, excelt hypertension hypercholesterolemia or cardiac murmurs known or sypmtomatic heart failure impaired kidney function (Cockcroft < 55 ml/min) known contrast allergy invasive angiography in past 2 years presence of life threatening disorder

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Radiation: CT coronary angiography|patient will undergo one CT coronary angiography|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| accurately identifying asymptomatic coronary artery disease | to determine whether Ct coronary angiography as a screening method acuurately identifies asymptomatic coronary artery disease in a high risk poulation (HL survivors after mediastinal irradiation) | one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prevalnce of cornary artery disease and frequency/type of subsequent intervention | to establish the prevelence of coronary abnormalities in HL survivors treated with mediastinal irradiation, and to determine the frequency and type of subsequent interventions | one year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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radiation therapy, coronary artery disease, Hodgkin Lymphoma