Liver Enzymes and Metabolic Risk Factors Response to Laser Acupuncture Versus Cupping Therapy in Fatty Liver

Study Overview
=================
Brief Summary
-----------------
fatty liver disease is characterized by low antioxidants, disturbed lipid metabolism, cardioautonomic functions, and elevated blood measures (glucose, inflammatory markers, liver enzymes)

Detailed Description
-----------------
In fatty liver patients,applied cupping (with scarification) will be compared, regarding its effect on antioxidant, lipid metabolism, cardioautonomic functions, and blood measures (glucose, inflammatory markers, liver enzymes), to application of laser on acupoints

Official Title
-----------------
Hepatic Enzymes and Metabolic-Risk Factors Responses to Laser Acupuncture Versus Cupping Therapy in Fatty Liver

Conditions
-----------------
Fatty Liver

Intervention / Treatment
-----------------
* Device: laser acupuncture
* Other: wet cupping


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: fatty liver obese patients Exclusion Criteria: thoracic diseases heart diseases kidney diseases

Ages Eligible for Study
-----------------
Minimum Age: 35 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: laser on acupuncture points<br>In fatty liver diseased patients which their number will be 30 patients, a 3-session/week application of 2-minute laser (for 3 months) on acupoint number 25,40,36 of stomach meridian, acupoints number 3 and 14 of liver meridian, acupoint number 6 of spleen meridian,acupoint number 9.12,4 of conception vessel meridian, acupoint number 14 of governor vessel meridian, acupoint number 4, 11 of large intestine meridian, acupoint number 34 of gall bladder meridian | Device: laser acupuncture<br>* In fatty liver diseased patients which their number will be 30 patients, a 3-session/week application of 2-minute laser (for 3 months) on acupoint number 25,40,36 of stomach meridian, acupoints number 3 and 14 of liver meridian, acupoint number 6 of spleen meridian,acupoint number 9.12,4 of conception vessel meridian, acupoint number 14 of governor vessel meridian, acupoint number 4, 11 of large intestine meridian, acupoint number 34 of gall bladder meridian<br>|
| Active Comparator: cupping (with scarification)<br>in this fatty liver diseased patients which their number will be 30, cupping (with scarification) or wet cupping will be applied at the first day and the day number 14 in the month for three successive months. cupping (with scarification) or wet cupping will be applied on urinary bladder acupoint 17 (on the both sides) and governosal vessels acupoints 12,13,and 14. | Other: wet cupping<br>* in this fatty liver diseased patients which their number will be 30, cupping (with scarification) or wet cupping will be applied at the first day and the day number 14 in the month for three successive months. cupping (with scarification) or wet cupping will be applied on urinary bladder acupoint 17 (on the both sides) and governosal vessels acupoints 12,13,and 14.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| high density lipoprotein | it is a component of lipid profile | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cholesterol | it is a component of lipid profile | 12 weeks | 
| low density lipoprotein | it is a component of lipid profile | 12 weeks | 
| triglycerides | it is a component of lipid profile | 12 weeks | 
| blood glucose | fasting level of blood glucose will be measured | 12 weeks | 
| C reactive protein | high sensitivity levels C reactive protein will be measured | 12 weeks | 
| Malondialdehyde | it ts oxidative stress marker | 12 weeks | 
| aspartate transaminase | it is a hepatic enzyme that reports the functions of liver | 12 weeks | 
| alanine transaminase | it is a hepatic enzyme that reports the functions of liver | 12 weeks | 
| systolic blood pressure | it will be measured by sphygmomanometer | 12 weeks | 
| diastolic blood pressure | it will be measured by sphygmomanometer | 12 weeks | 
| pulse rate | it will be measured manually | 12 weeks |