Osteoarthrosis on 7.0T Magnetic Resonance Imaging

Study Overview
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Brief Summary
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This clinical trial studies the use of 7-Tesla (7T)and 3T magnetic resonance imaging (MRI) in detecting osteoarthrosis. 7T MRI has increased detection sensitivity, including more accurate lesion delineation, higher inter-rater agreement. Diagnostic procedures such as 7T MRI may help ultimately improved diagnostic and therapies confidence to inform decision making than standard 3T MRI.

Detailed Description
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7T MRI increased detection sensitivity, attain superior anatomic resolution, higher spatial and spectral specificity of advanced quantitative techniques, and shorter scan times than 3T MRI. When applied clinically, these benefits translate to increased detection sensitivity, and ultimately improved diagnostic and therapies confidence to inform decision making. This study aim to detect the image characteristics and diagnostic accuracy of osteoarthrosis on 7T MRI.

Official Title
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Osteoarthrosis on 7.0T Magnetic Resonance Imaging

Conditions
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MRI, Osteoarthrosis

Intervention / Treatment
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* Diagnostic Test: Magnetic resonance imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age≥18 and ≤80 Having no contraindications against MRI Clinically stable Exclusion Criteria: Age#18 or #80 Pregnancy and other contraindication to MRI scan Informed consent not obtained

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Magnetic resonance imaging|Patients recruited will receive Magnetic resonance imaging.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The thickness of the cartilage of patellar on 7T MRI scan | Thickness of different part of the cartilage of patellar measured based on axial PD images | baseline | 
| The T2 mapping value of the patellar cartilage on 7T MRI scan | T2 relaxation times of the patellar cartilage measured based on T2 mapping | baseline | 
| The abnormal signal in the infrapatellar fat pad | The exist of abnormal signal in the infrapatellar fat pad detected based on sagittal PD images | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Signal change of the patellar chondral before and after rehabilitation | The correlation between abnormal change of the patellar chondral and reaction 1 month after rehabilitation | 1 month after rehabilitation | 
| Signal change of the infrapatellar fat pad before and after rehabilitation | The correlation between abnormal signal in the infrapatellar fat pad and reaction 1 month after rehabilitation | 1 month after rehabilitation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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MRI, Osteoarthrosis