Evaluation of Amnion Chorion Membrane and Demineralized Bone Matrix Putty Allograft in Periodontal Intrabony Defects

Study Overview
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Brief Summary
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A clinical and radiographic evaluation of 2 regenerative techniques, bioresorbable membrane and bone allograft for management of periodontal intrabony defects.

Detailed Description
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Twenty-two patients suffering from advanced chronic periodontitis were included in this randomized controlled clinical trial. Each subject contributed had two- or three-walled intrabony defects. Patients were randomly assigned into two groups; bioresorbable membrane or bone allograft. Clinical parameters were recorded at baseline and at 3 and 6 months postoperatively. Radiographic parameters were recorded at baseline and at 6 months postoperatively.

Official Title
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Clinical and Radiographic Evaluation of Amnion Chorion Membrane and Demineralized Bone Matrix Putty Allograft for Management of Periodontal Intrabony Defects: a Randomized Clinical Trial.

Conditions
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Chronic Periodontitis

Intervention / Treatment
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* Biological: Demineralized bone matrix in putty form
* Biological: Amnion chorion membrane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Severe chronic periodontitis patients. having at least one site with pocket depth ≥ 6 mm and clinical attachment level ≥ 5 mm, with radiographic evidence of bone loss as detected in periapical radiographs. Exclusion Criteria: Pregnant women Having any given systemic disease Taking any type of medication and/or antibiotic therapy during the 3 months before the study Received periodontal treatment within the past 12 months Current or former smokers

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Bone allograft<br>commercially available demineralized bone matrix putty allograft will be used to fill in the defect after opening a periodontal flap | Biological: Demineralized bone matrix in putty form<br>* it is a type of bone graft from human cadavers.<br>* Other names: DBM;|
| Experimental: Amnion chorion membrane<br>Amnion chorion commercially available allograft bioresorbable membrane as a guided tissue regeneration technique will be used to in the defect after opening a periodontal flap | Biological: Amnion chorion membrane<br>* A bioresorbable allograft membrane for guided tissue regeneration from amnion and chorion parts of the placenta from pregnant females for guided tissue regeneration.<br>* Other names: bioresorbable membrane;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical attachment level | Change from baseline in clinical attachment level in mm in chronic periodontitis patients | change from Baseline at 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pocket depth | Estimation of pocket depth in mm in chronic periodontitis patients at baseline and 6 months | Baseline and 6 months | 
| bone defect area | Estimation of bone fill defect area in mm square in chronic periodontitis patients at baseline and 6 month | Baseline and 6 months |