Is COPD a Risk Factor for Cardiovascular Disease?

Study Overview
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Brief Summary
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Patients with chronic obstructive pulmonary disease suffer from significant cardiovascular morbidity and mortality. This study wants to determine whether chronic obstructive pulmonary disease might be a risk factor for coronary atherosclerosis and other cardiac markers independent of conventional cardiovascular risk factors. The study is designed as a retrospective matched case-control study with follow-up via telephone interview.

Detailed Description
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Patients with chronic obstructive pulmonary disease (COPD) suffer from significant cardiovascular morbidity and mortality. Coronary artery disease has often been linked causally to COPD, but the exact pathophysiological mechanisms underpinning this association remain speculative. A retrospective case-control study matching COPD patients and controls one to one for smoking history and conventional cardiovascular risk factors will be performed to study the association between COPD and cardiovascular outcomes. Filling in this knowledge gap may contribute to the understanding of the interplay between COPD and cardiovascular disease. The objective of this retrospective case-control study is to determine whether COPD might be a risk factor for coronary atherosclerosis, impaired left ventricular ejection fraction, and major adverse cardiovascular events independent of conventional cardiovascular risk factors.

Official Title
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Is Chronic Obstructive Pulmonary Disease a Risk Factor for Cardiovascular Disease?

Conditions
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Chronic Obstructive Pulmonary Disease

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: SPECT-CT imaging due to preoperative assessment between 01.01.2007 and 31.07.2013. Coronary artery calcium score and left ventricular ejection fraction data available. History of smoking (smoker or ex-smoker). COPD group: Documented chronic obstructive pulmonary disease (post-bronchodilator FEV1/FVC < 0.7). Control group: Exclusion of chronic obstructive pulmonary disease (post-bronchodilator FEV1/FVC > 0.7). Exclusion Criteria: Known coronary artery disease or coronary symptoms (angina pectoris) at the time of the SPECT-CT investigation. Known congenital or structural heart disease. Previous heart transplantation.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Chronic obstructive pulmonary disease<br>Approximately 100 participants with documented chronic obstructive pulmonary disease (post-bronchodilator Forced expiratory volume in 1 second (FEV1)/Forced vital capacity (FVC) < 0.7). | |
| Control<br>Approximately 100 participants with exclusion of chronic obstructive pulmonary disease (post-bronchodilator Forced expiratory volume in 1 second (FEV1)/Forced vital capacity (FVC) > 0.7). | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Coronary calcium score in cardiac computed tomography | Retrospective assessment of SPECT-CT imaging data at the University Hospital Zurich. | Up to one month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Left ventricular ejection fraction in single-photon emission computed tomography | Retrospective assessment of SPECT-CT imaging data at the University Hospital Zurich. | Up to one month | 
| Major adverse cardiovascular events | Follow-up via telephone interview for major adverse cardiovascular events. | Up to three months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Chronic obstructive pulmonary disease, Coronary artery disease, Coronary calcium score