Brain Perfusion Assessment in the Acute Phase of Migraine Aura

Study Overview
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Brief Summary
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The aim of the study is to determine the proportion of patients with change in brain perfusion during the acute phase of migraine attack with aura.

Detailed Description
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Migraine is a benign and frequent disorder. Migraine aura consists in reversible focal neurological symptoms developing gradually during attack. Its diagnosis relies mainly on patient's history, clinical examination and exclusion of other possible secondary causes to explain transient neurological signs. Thus it can be difficult particularly during first attack or during attack without headache to differentiate migraine aura from transient ischemic stroke. Considering the difference of care management and prognosis, an early distinction of migraine aura based on imaging techniques will have a particular interest. MRI with diffusion, SWI, Flair 2D, ARM 3D TOF, ASL sequences' are routinely performed for the management of acute neurological deficit. Arterial spin labeling (ASL), as a MR perfusion method, will be used to describe brain perfusion during migraine aura. The study hypothesis is that hyperperfusion occurs in brain territories corresponding to the neurological symptoms during migraine aura.

Official Title
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Brain Perfusion Assessment in the Acute Phase of Migraine Aura.

Conditions
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Emergencies

Intervention / Treatment
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* Other: the difference of care management and prognosis, an early distinction of migraine aura based on imaging techniques will have a particular interest


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age between greater than or equal to 18 Able to undergo MRI during migraine aura Exclusion Criteria: Pregnant females Contraindications towards MRI scanning History of epilepsy, psychiatric disease, or any other neurologic disease (brain tumors, stroke..). Presence of abnormalities on the MRI that could explain the neurological deficit. Adults under guardianship or trusteeship

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: the difference of care management and prognosis, an early distinction of migraine aura based on imaging techniques will have a particular interest|the difference of care management and prognosis, an early distinction of migraine aura based on imaging techniques will have a particular interest|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Perfusion pattern of concerned brain areas | Presence or absence of hypo-hyperperfusion using arterial spin labeling. Visual assessments and comparison between hemispheres | 1 hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pattern of perfusion and aura duration | Change in brain perfusion in relation to neurological deficits (migraine aura) duration. | 12 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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migraine, perfusion arterial, aura brain