Vorinostat, Bortezomib, and Doxorubicin Hydrochloride Liposome in Treating Patients With Relapsed or Refractory Multiple Myeloma

Study Overview
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Brief Summary
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RATIONALE: Vorinostat and bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Bortezomib may also stop the growth of multiple myeloma by blocking blood flow to the tumor. Drugs used in chemotherapy, such as doxorubicin hydrochloride liposome, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving doxorubicin hydrochloride liposome together with vorinostat and bortezomib may kill more cancer cells. PURPOSE: This phase I trial is studying the side effects and best dose of vorinostat and to see how well it works when given together with bortezomib and doxorubicin hydrochloride liposome in treating patients with relapsed or refractory multiple myeloma.

Detailed Description
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OBJECTIVES: Primary To determine the maximum tolerated dose of vorinostat when added to the standard regimen of bortezomib and pegylated liposomal doxorubicin hydrochloride in patients with relapsed or refractory multiple myeloma. To identify the dose-limiting toxicities of this regimen in these patients. Secondary To gain preliminary evidence of antitumor activity of this regimen in these patients. To assess the degree of proteasome inhibition achieved with this regimen in these patients. To evaluate the accumulation of acetylated alpha-tubulin after treatment with vorinostat. To evaluate overall survival, time to progression, and progression-free survival of patients treated with this regimen. OUTLINE: This is a multicenter, dose escalation study of vorinostat. Patients receive oral vorinostat once daily on days 1,2; 4,5; 8, 9; 11, 12; bortezomib IV on days 1, 4, 8, and 11, and pegylated liposomal doxorubicin hydrochloride IV on day 4. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Blood samples are collected periodically for proteasome inhibition assays and acetylated alpha-tubulin studies. After completion of study treatment, patients are followed at 1 and 3 months.

Official Title
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A Phase 1 Dose Escalation Study of Bortezomib (Velcade®), Pegylated Liposomal Doxorubicin (Doxil®), and Vorinostat (Suberoylanilide Hydromaxic Acid, Saha, Zolinzatm) in Patients With Relapse/Refractory Multiple Myeloma

Conditions
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Multiple Myeloma and Plasma Cell Neoplasm

Intervention / Treatment
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* Drug: bortezomib
* Drug: pegylated liposomal doxorubicin hydrochloride
* Drug: vorinostat


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Diagnosis of multiple myeloma Relapsed or refractory disease PATIENT CHARACTERISTICS: ECOG performance status 0-2 Life expectancy ≥ 3 months ANC ≥ 1.0 x 10^9/L (no granulocyte growth factor support, e.g., G-CSF or GM-CSF allowed) Platelet count ≥ 100 x 10^9/L (erythropoietin allowed, no platelet or RBC transfusion within the past 2 weeks) Hemoglobin ≥ 8 g/dL (erythropoietin allowed, no platelet or RBC transfusion within the past 2 weeks) Creatinine clearance ≥ 30 mL/min AST or ALT ≤ 2.5 times upper limit of normal (ULN) Total bilirubin ≤ 1.5 times ULN Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception during and for 3 months after completion of study treatment LVEF ≥ 45% by MUGA or ECHO Symptomatic neuropathy < grade 2 No known history of HIV No active or serious infection, medical or psychiatric illness that would preclude study participation No active hepatitis B or C infection No other prior or concurrent malignancy except for adequately treated basal cell or squamous cell carcinoma of the skin, in situ malignancy, low-risk prostate cancer after curative therapy, or other cancer for which the patient has been disease-free for ≥ 3 years No history of hypersensitivity reaction to bortezomib or any of its components (boron, mannitol), vorinostat, doxorubicin hydrochloride, or any of the components of PLD No serum potassium ≤ 3.0 or serum magnesium ≤ 1.6 that cannot be corrected with supplementation are excluded Patients must have adequate cardiovascular function, defined by all of the following: No EKG evidence of active, clinically significant conduction system abnormalities No EKG evidence of QTc prolongation > grade 2 NOTE: Any EKG abnormality at screening has to be documented by the investigator as not medically significant. PRIOR CONCURRENT THERAPY: No limit to number of prior treatment regimens At least 30 days since prior therapy and recovered At least 3 months since prior autologous stem cell transplantation and recovered Prior allogeneic stem cell or bone marrow transplantation allowed provided the following criteria are met: More than 1 year since transplantation No longer receiving immunosuppressive therapy or treatment for graft-versus-host disease (GVHD) prophylaxis No active GVHD No active, uncontrolled infections No major surgery within the past 3 weeks No prior anthracycline dose > 360 mg/m^2 for doxorubicin hydrochloride (including pegylated liposomal doxorubicin hydrochloride [PLD]) or 720 mg/m^2 for epirubicin hydrochloride No prior or concurrent histone deacetylase inhibitor (e.g., valproic acid) No concurrent filgrastim (G-CSF) or sargramostim (GM-CSF) during course 1 No other concurrent investigational or anticancer agent

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Non-Randomized Open Label Single Arm<br>Phase 1 dose escalation trial of vorinostat in combination with bortezomib and pegylated liposomal doxorubicin hydrochloride. | Drug: bortezomib<br>* Intravenous Push 1.3 mg/m2 Days 1, 4, 8, and 11<br>* Other names: Velcade;Drug: pegylated liposomal doxorubicin hydrochloride<br>* Intravenous infusion, 30mg/m2, Day 4, each cycle<br>* Other names: Doxil;Drug: vorinostat<br>* Oral, 300mg, Days 1, 2, 4, 5, 8, 9, 11, 12, every cycle.<br>* Other names: Zolinza;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximum tolerated dose of vorinostat |  | 4 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall response rate |  | 5 years | 
| Duration of response |  | 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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refractory multiple myeloma, stage I multiple myeloma, stage II multiple myeloma, stage III multiple myeloma