The Effect of β-hydroxy-β-methylbutyrate Supplementation on Physical Capacity and Body Composition in Trained Athletes

Study Overview
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Brief Summary
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The purpose of this study was to verify the effect of 12-week with β-hydroxy-β-methylbutyrate (HMB) and a placebo (PLA) supplementation on body composition, anaerobic and aerobic capacity, as well as concentrations of the selected biochemical blood markers in trained athletes, in a randomised, double-blind, placebo-controlled crossover trial.

Detailed Description
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The effect of HMB supplementation is of great interest in sport. In view of the inconclusive character of the results of the studies conducted to date and of a relatively low number of studies investigating the effectiveness of HMB supplementation over a longer period on a large population of trained athletes, the aim of this study was to verify the effect of 12-week with HMB and a placebo supplementation on body composition, anaerobic and aerobic capacity, as well as concentrations of the selected biochemical blood markers in trained athletes, in a randomised, double-blind, placebo-controlled crossover trial.

Official Title
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The Effect of β-hydroxy-β-methylbutyrate (HMB) Supplementation on Physical Capacity and Body Composition in Trained Athletes

Conditions
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Sport, Supplements, Supplementation

Intervention / Treatment
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* Dietary Supplement: β-hydroxy-β-methylbutyrate and a placebo supplementation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: written consent to participate, male a current medical clearance to practice sports, training experience: at least 5 years, minimum of 6 workout sessions a week (minimum 3 in the practiced sports discipline). Exclusion Criteria: current injury, any health-related contraindication, declared general feeling of being unwell, unwilling to follow the study protocol.

Ages Eligible for Study
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Minimum Age: 17 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: β-hydroxy-β-methylbutyrate (HMB)<br>Group taking oral supplementation with calcium salt of β-hydroxy-β-methylbutyric acid produced by Olimp Laboratories. A single capsule contained 1250 mg Ca-HMB, which corresponds to 1000 mg of β-hydroxy-β-methylbutyrate. Interventions: The experimental procedure for each athlete included a 12-week HMB supplementation - 3 capsules of the assigned preparation a day in 3 doses: upon waking, immediately after training, and before sleep. On non-training days, the participants were instructed to consume one serving with each of three separate meals throughout the day. Between the 12-week HMB and PLA or a PLA and HMB treatment, a 10-day washout period was introduced. | Dietary Supplement: β-hydroxy-β-methylbutyrate and a placebo supplementation<br> <br> |
| Placebo Comparator: Placebo (maltodextrin)<br>Group taking oral supplementation with placebo (maltodextrin). A single capsule contained 1000 mg of maltodextrin. Interventions: The experimental procedure for each athlete included a 12-week placebo administration - 3 capsules of the assigned preparation a day in 3 doses: upon waking, immediately after training, and before sleep. On non-training days, the participants were instructed to consume one serving with each of three separate meals throughout the day. Between the 12-week HMB and PLA or a PLA and HMB treatment, a 10-day washout period was introduced. | Dietary Supplement: β-hydroxy-β-methylbutyrate and a placebo supplementation<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of body composition indices after HMB supplementation | Analysis of the fat mass and fat free mass | Baseline and after 12 weeks | 
| Changes of body composition indices after placebo treatment | Analysis of the fat mass and fat free mass | Baseline and after 12 weeks | 
| Changes of aerobic capacity after HMB supplementation |  | Baseline and after 12 weeks | 
| Changes of aerobic capacity after placebo treatment |  | Baseline and after 12 weeks | 
| Changes of anaerobic capacity after HMB supplementation |  | Baseline and after 12 weeks | 
| Changes of anaerobic capacity after placebo treatment |  | Baseline and after 12 weeks | 
| Changes of creatine kinase and lactate dehydrogenase activity in blood after HMB supplementation |  | Baseline and after 12 weeks | 
| Changes of creatine kinase and lactate dehydrogenase activity in blood after placebo treatment |  | Baseline and after 12 weeks | 
| Changes of testosterone, cortisol and lactate levels in blood after HMB supplementation |  | Baseline and after 12 weeks | 
| Changes of testosterone, cortisol and lactate levels in blood after placebo treatment |  | Baseline and after 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Statistical evaluation of the significance of differences between the changes in body composition (fat mass and fat free mass) |  | 1 year | 
| Statistical evaluation of the significance of differences between the changes in aerobic capacity indices |  | 1 year | 
| Statistical evaluation of the significance of differences between the changes in anaerobic capacity indices |  | 1 year | 
| Statistical evaluation of the significance of differences between the changes in creatine kinase and lactate dehydrogenase activity and testosterone, cortisol and lactate levels in blood |  | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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β-hydroxy-β-methylbutyric acid, Sport supplements, Training support, Adaptation