Factors Affecting Caloric Regulation in Human Feeding

Study Overview
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Brief Summary
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This study will test the hypothesis that reducing the energy density of the diet by incorporating more water-rich foods will result in: 1) greater weight loss and weight maintenance; 2) greater diet satisfaction and satiety; and 3) more healthful dietary patterns than reducing dietary fat alone.

Detailed Description
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Energy density refers to the amount of calories (energy) in a given weight of food. For the same amount of energy, a larger volume (weight) of food can be consumed if the food or diet is low in energy density than if the food or diet is high in energy density. The two nutrients that have the largest impact on energy density are fat and water. Foods high in fat and low in water content are typically high in energy density, whereas foods low in fat and high in water content, such as fruits and vegetables, are low in energy density. This study will examine whether there are increased benefits for weight loss and weight maintenance when the ad libitum consumption of water-rich foods is added to a reduced-fat diet, thus making it even lower in energy density. Comparisons: Reduced-energy-dense diet and Reduced-fat diet

Official Title
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The Effect of Decreases in Energy Density on Weight Loss and Weight Maintenance

Conditions
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Obesity

Intervention / Treatment
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* Behavioral: Reduced-energy-density diet


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy women BMI (body mass index) 30 through 40 kg/m2 Normal blood pressure LDL (low density lipoprotein)-cholesterol < 90th percentile recommendations Triglycerides, fasting blood glucose, and all other blood values within normal ranges Able to participate in low to moderate physical activity. Exclusion Criteria: Heart disease Diabetes - type I or II High blood pressure Renal or kidney disease Gastrointestinal disease Blood clotting disorder Liver disease or cirrhosis Any oral steroids Gout (requiring treatment) Anemia Lung disease Cancer within the last 5 years Thyroid disease

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Reduced-energy-density diet|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Weight loss |  |  | 
| Weight maintenance |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in diet: quality and patterns, energy density, and fat content |  |  | 
| Changes in lipids |  |  | 
| Satisfaction with the two different dietary methods for weight loss |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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weight loss, reduced-energy-density diet, fat-restricted diet, fruit, vegetables, ad libitum intake, obesity