linjc16/ctgov huggingface dataset:
Ultrasound-based Intima-Media Thickness Measurements

Study Overview
=================
Brief Summary
-----------------
Develop a standard technique and demonstrate adequate precision for measurement of intima-media thickness (IMT) for routine clinical use.

Detailed Description
-----------------
IMT is measured using software to analyze ECG-gated US image sequences acquired using a standard protocol. Two sonographers acquire images and measure IMT for 100 vessels. IMT technique standard deviation (SD) is determined by assuming normally distributed measurements, and dividing the SD of the 100 (paired) IMT differences by sqrt(2). This SD will be taken as measures of precision of the IMT technique.

Official Title
-----------------
Determination of the Precision and Clinical Utility of Ultrasound-based Intima-Media Thickness Measurements

Conditions
-----------------
Carotid Artery Intima Media Thickness

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Must have an appointment at either the Cardiovascular Health Clinic or scheduled for a carotid ultrasound. Exclusion Criteria: Carotid endarterectomy,carotid stenting, carotid repair, less than 45 degree range of motion in the neck, and/or cannot lie flat on back. Participants Enrolled who are found after imaging not to exhibit a  1cm long common carotid far wall region free of focal plaque in which to measure IMT will not have their data analyzed further.

Ages Eligible for Study
-----------------
Minimum Age: 35 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Men, age 35 to 65, being seen at the Mayo Clinic Department of Cardiovascular Health clinic, or has an appointment for a carotid duplex ultrasound exam. | |
| 2<br>Women, age 35 to 65, being seen at the Mayo Clinic Department of Cardiovascular Health clinic, or has an appointment for a carotid duplex ultrasound exam. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The primary statistical endpoint for this study is to determine the standard deviation and 95% confidence interval of IMT measurements obtained using our standard method. |  | Four years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Standard deviation and 95% confidence interval of our IMT measurement method considering data subsets with variable US image quality levels, and different levels of image plane correlation. |  | Two years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
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Carotid artery, Common carotid artery, Measurement, Ultrasound
Pain Relief for Birth Control Implants Insertion

Study Overview
=================
Brief Summary
-----------------
The aim of our study is to compare the analgesic effect of topical application of lidocaine-prilocaine cream and lidocaine infiltration during insertion of birth control implants

Official Title
-----------------
Topical Lidocaine-prilocaine Cream Versus Lidocaine Infiltration for Pain Relief During Insertion of Subcutaneous Birth Control Implants : A Randomized Controlled Trial

Conditions
-----------------
Contraception, Lidocaine

Intervention / Treatment
-----------------
* Drug: Lidocaine Injectable Product
* Drug: Lidocaine Topical Cream [LMX]


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: female want use subcutaneous birth control Exclusion Criteria: previous scar at side of insertion

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: lidocaine injection<br> | Drug: Lidocaine Injectable Product<br>* 3 cm of Lidocaine- will be injected subcutaneous for 5 minutes before insertion of subcutaneous birth control implant<br>|
| Experimental: lidocaine-prilocaine cream<br> | Drug: Lidocaine Topical Cream [LMX]<br>* 3 mg of Lidocaine- will be applied to skin for 5 minutes before insertion of subcutaneous birth control implant<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean pain score during insertion of implant |  | 10 minutes |
Volumetric Study of the Buttocks After Flap Augmentation in Buttocks Lifting

Study Overview
=================
Brief Summary
-----------------
The development of bariatric surgery, its effectiveness and the reduction of complications are at the origin of massive weight loss, the corollary of which has been a clear increase in the demands of treatment of sequelae of weight loss.

Official Title
-----------------
Prospective Study of Volumetric Gluteal Region by Parasacral Perforator Flaps in Circumferential Body Lift

Conditions
-----------------
Weight Loss

Intervention / Treatment
-----------------
* Procedure: gluteal augmentation with flap in circumferential body lift


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: 12 months minimum delay with bariatric surgery female, BMI<30kg/m2 Age greater than or equal to 18 years Stable weight for more than 6 months lack of volume in gluteal region agree with clinical trial Exclusion criteria: Patient under tutorship or curatorship Pregnancy or breastfeeding hemoglobinemia< 12g/dL Albuminemia<3,5g/dL active smoking more than 1 month before surgery

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: gluteal augmentation with flap in circumferential body lift|classic circumferential bodylift surgery, using two different well-known flaps for gluteal augmentation|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Volumetric increase by para-sacral flap | evaluate the gluteal volume after augmentation with a parasacral flap using a 3D camera | day before the operation | 
| Volumetric increase by para-sacral flap | evaluate the gluteal volume after augmentation with a parasacral flap using a 3D camera | then at the 3th month post surgery | 
| Volumetric increase by para-sacral flap | evaluate the gluteal volume after augmentation with a parasacral flap using a 3D camera | then at the 6th month post surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical evolution | Results of clinical evaluation : look for seroma andhematoma during hospitalization | During hospitalization (Day 0 to Day 5) | 
| Results of clinical evolution | clinical evaluation : look for seroma and hematoma post surgery | Day 15 | 
| Results of clinical evolution | clinical evaluation : look for seroma and hematoma then at the 2nd week after surgery | 2nd week after surgery | 
| Results of clinical evolution | clinical evaluation : look for seroma and hematoma then at 3rd week after surgery | 3rd week after surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
plastic and reconstructive surgery, gluteal ptosis, platipygia
Safety and Feasibility of Early Active Rehabilitation in Children After Concussion

Study Overview
=================
Brief Summary
-----------------
It has been suggested that activity immediately following concussion is detrimental to recovery and may lead to long term impairments. The animal model has shown that exercise too soon can lead to neurometabolic energy imbalances within the brain. However, there is also evidence to suggest that prolonged inactivity has negative consequences that may contribute to prolongation of symptoms. Determining the ideal timeframe in which to initiate an active rehabilitation protocol for patients who are slow to recovery is an important factor in concussion management.

Official Title
-----------------
Safety and Feasibility of Early Active Rehabilitation in Children After Concussion

Conditions
-----------------
Post-Concussion Symptoms, Concussion

Intervention / Treatment
-----------------
* Other: Active Rehabilitation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: referred to the mTBI clinic of the MCH for atypical recovery (defined as the presence of symptoms with little improvement at 10 days post-injury preventing them from entering standard return to activities protocols) Exclusion Criteria: co-morbidity preventing children from participating in intervention

Ages Eligible for Study
-----------------
Minimum Age: 8 Years
Maximum Age: 17 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Early Rehab<br>Children will begin active rehabilitation 2 weeks post-injury | Other: Active Rehabilitation<br> <br> |
| Active Comparator: late rehab<br>Children will begin active rehabilitation 4 weeks post-injury | Other: Active Rehabilitation<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Post-concussion symptoms | Post-Concussion Symptoms Inventory scale total score | 6 weeks post-injury |
Acne and Mood: Impact of Treatment on Depression, Anxiety, and Sexual Function

Study Overview
=================
Brief Summary
-----------------
This study seeks to examine if there is any relationship between spironolactone use prescribed for acne vulgaris and depression, anxiety, and/or sexual function.

Official Title
-----------------
Acne and Mood: Impact of Treatment on Depression, Anxiety, and Sexual Function

Conditions
-----------------
Acne Vulgaris

Intervention / Treatment
-----------------
* Other: Online survey


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Female subjects between 18 and 65 years of age currently taking spironolactone for a diagnosis of acne vulgaris OR Female subjects between 18 and 65 years of age currently taking oral antibiotics for a diagnosis of acne vulgaris AND Subjects able to complete an online survey in English Exclusion Criteria: Subjects less than 18 years of age or older than 65 years of age Subjects that have ever been diagnosed with any mood disorder by a clinician prior to starting spironolactone (history of mood disorder or current mood disorder) Subjects taking hormonal contraception (including but not limited to oral contraceptive pills) for a duration of less than 6 months Subjects that have ever been diagnosed with any type of sexual dysfunction prior to starting spironolactone Subjects not able to complete an online survey in English Subjects taking oral isotretinoin for a diagnosis of acne Subjects that are currently pregnant

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
Female

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Subjects on spironolactone for a diagnosis of acne vulgaris<br>Female subjects between 18 and 65 years of age currently taking spironolactone for a diagnosis of acne vulgaris | Other: Online survey<br>* Online survey completion through Northwestern's REDCap<br>|
| Subjects on oral antibiotics for a diagnosis of acne vulgaris<br>Female subjects between 18 and 65 years of age currently taking oral antibiotics for a diagnosis of acne vulgaris | Other: Online survey<br>* Online survey completion through Northwestern's REDCap<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percent correlation between spironolactone use for acne vulgaris and increased prevalence of depression. | Score for depression from subject reported Dermatology Life Quality Index (DLQI) survey | one week | 
| Percent correlation between spironolactone use for acne vulgaris and increased prevalence of anxiety. | Score for depression from subject reported Generalized Anxiety Disorder (GAD-7) survey | two weeks | 
| Percent correlation between spironolactone use for acne vulgaris and increased prevalence of sexual dysfunction. | Score for depression from subject reported Female Sexual Function Index (FSFI) survey. | four weeks |
Association Between Fuchs' Endothelial Corneal Dystrophy Severity and Estrogen Exposure

Study Overview
=================
Brief Summary
-----------------
This study is being done to discover if there is a link between estrogen exposure and the severity of Fuchs Endothelial Corneal Disease. We are trying to understand if the decrease in estrogen levels in post-menopausal women may be a reason why FECD is seen more often in women than men.

Official Title
-----------------
Association Between Fuchs' Endothelial Corneal Dystrophy Severity and Estrogen Exposure

Conditions
-----------------
Fuchs Dystrophy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Individuals with FECD grade 1-2/7 (mild) or 5-6/7 (severe) in one or both eyes Age ≥ 55 Phakic and pseudophakic individuals will be included. Pseudophakic patients must have evidence of routine cataract surgery (posterior chamber intraocular lens in-the-bag without clinical evidence of damage to any intraocular structures). Exclusion Criteria: Females are excluded if not post-menopause. Pseudophakic patients with a history of complex cataract surgery or other intraocular surgery (e.g. have an anterior chamber lens, sulcus lens, or poorly positioned posterior chamber lens, aphakia, iris damage, glaucoma surgery) will be excluded due to risk of iatrogenic damage to the corneal endothelium.

Ages Eligible for Study
-----------------
Minimum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Mild Fuchs Dystrophy<br> | |
| Severe Fuchs Dystrophy<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Association Between Fuchs endothelial Corneal Dystophy Severity and Estrogen Exposure | Difference in measures of estriadiol exposure between individuals with mild vs. severe FECD | 5 years |
Laser Treated vs SLA Treated Short Implants in Terms of Stability.

Study Overview
=================
Brief Summary
-----------------
Laser treated short dental implants will be placed in a posterior atrophic ridge with only 8-10 mm available bone height. Their stability will be measured through a period of 12 weeks. They will be compared to the stability of SLA treated Short dental implants placed in the same situations.

Detailed Description
-----------------
Laser treated short dental implants will be placed in a posterior atrophic ridge with only 8-10 mm available bone height. Their stability will be measured through a period of 12 weeks. They will be compared to the stability of SLA treated Short dental implants placed in the same situations.

Official Title
-----------------
Implant Stability in Laser Treated Surface vs SLA Treated Short Implants (Randomized Clinical Trial)

Conditions
-----------------
Will Laser Treated Dental Implants Improve Stability Early Healing

Intervention / Treatment
-----------------
* Device: Laser and SLA


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: • Adult patients with Edentulous posterior maxillae with insufficient ridge for placement of standard length dental implant, but allowing placement of short 8mm dental implant. Males and females. Exclusion Criteria: • Heavy smokers more than 20 cigarettes per day. Patients with systemic disease that may affect normal healing. Psychiatric problems Disorders to implant are related to history of radiation therapy to the head and neck neoplasia, or bone augmentation to implant site Patients suffering from immunodeficiency, bruxism, stress situation (socially or professionally), emotional instability, and unrealistic aesthetic demands. Intraoral soft and hard tissue pathology.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Laser and SLA implants<br>Surgical placement of short implants in maxillary posterior teeth with Laser surface treated and SLA surface treated dental implants | Device: Laser and SLA<br>* Patients will be randomized into two groups, control group for SLA implants, and study group will receive the Laser treated implants. Implants will be placed classically in the posterior maxillary region and their stability will be measured by ISQ device at the placement. Measurements will be taken again at 2, 4, 6, 8 , 10 and 12 weeks.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of change in implant stability at base line, 2,4,8, 12 weeks | measuring implant stability with resonance frequency analysis device using implant stability quotation (ISQ) that measures the stiffness and deflection of implant bone complex. | 3 months |
Community Based Prevention/Control Project

Study Overview
=================
Brief Summary
-----------------
This project is aimed at better understanding how children living in agricultural environments are exposed to pesticides, and how such exposures can be prevented or reduced. The project will develop and implement a community-wide intervention to reduce the transfer of pesticides from the workplace to the home (take home pathway).

Detailed Description
-----------------
This project is aimed at better understanding how children living in agricultural environments are exposed to pesticides, and how such exposures can be prevented or reduced. Since 1991 our group has investigated pesticide expsoures among children of agricultural families in Washington state, focusing on exposure to organophosphate insecticides. We have demonstrated in these studies that the residential environments of agricultural families have higher pesticide residues than do other homes in this region. We have also found that children living in these residential environments have elevated levels of pesticide metabolites in their urine. We need to better understand how these children are being exposed in order to develop recomendations for exposure prevention or reduction. The current project will develop and implement a community-wide intervention to reduce the transfer of pesticides from the workplace to the home (take home pathway). A complementary project is also underway by the UW-Child Health Center to characterize pesticide exposure pathways for children of farmworkers.

Official Title
-----------------
Child Environmental Health Center--Reducing Pesticide Exposure in Children of Farmworkers

Conditions
-----------------
Poisoning

Intervention / Treatment
-----------------
* Behavioral: Individual and Community education


Participation Criteria
=================
Eligibility Criteria
-----------------
Each family recruited must include one child between the ages of 1-5. Recruitment will be confined to the lower Yakima Valley.

Ages Eligible for Study
-----------------
Minimum Age: 1 Year

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Individual and Community education|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pesticide, Insecticide, Organophosphate, Child Health, Exposure Prevention