The Benefit of Functional Movement Control for Patients With Knee Osteoarthritis

Study Overview
=================
Brief Summary
-----------------
The study purpose is to explore the effect of functional movement control for patients who have stage II or III degenerative knee joint disease and also physical inactive. Half of patients will receive aerobic exercise and functional movement control training in combination, while the other will simply receive aerobic exercise.

Detailed Description
-----------------
Physical inactivity, which is a common phenomenon among patients with degenerative knee joint disease has been proved a predictor of increased symptoms and poor general health. However, changing the lifestyle of people with this disease who is physical inactive is still a problem which has not been solved. Knee pain may act as barrier to engage in physical activity and can influence patient's movement performance. The different effectiveness between the aerobic exercise and functional movement control training. Aerobic exercise has been proved could improve knee pain for the patients with degenerative knee joint disease. The functional movement control training could improve knee alignment during walking and other functional activities to increase patient's movement awareness.

Official Title
-----------------
The Benefit of Increasing Physical Activity and Functional Movement Control for Patients With Stage II or III Knee Osteoarthritis

Conditions
-----------------
Knee Osteoarthritis

Intervention / Treatment
-----------------
* Behavioral: Aerobic exercise & movement control
* Behavioral: Aerobic exercise


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Participant who was diagnosed has knee osteoarthritis Above 40 years old Participant who didn't achieve at least 150 min moderate intensity physical activity level per week Exclusion Criteria: Patients with walking disability Cannot complete 8 weeks intervention program Received arthroscopy or other surgery before 6 months

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Aerobic exercise & movement control<br>The duration of intervention is 8 weeks. Individualized functional movement control training is 60 min/week Aerobic exercise is 60 min/week | Behavioral: Aerobic exercise & movement control<br>* The aerobic exercise content is no different between the experimental group and the active comparator group. The movement control is individual training which divided into fourths progressing sessions. First, lumbo-pelvic and hip dynamic direction control. Second, trunk muscle groups, hip muscle groups and thigh muscle groups extensibility control. Third, trunk muscle groups and hip muscle groups through range control. Fourth, functional movement control training<br>|
| Active Comparator: Aerobic exercise<br>The duration of intervention is 8 weeks. Frequency: 2 times/ week Duration: 60min/ time | Behavioral: Aerobic exercise<br>* The aerobic exercise will organized in groups. Each group has 6-8 persons. The exercise form is fixed at each time. The description of exercise form is as below: 10 min Warm up 40 min Aerobic exercise (which focus on lower extremity muscle strengthening and increasing muscle endurance) 10 min Cool down<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| reaching proportions of the level of health enhancing physical activity | the recommended level of health enhancing physical activity is at least 150 min of moderate intensity physical activity per week | up to 6 months after intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Partial foot pressure as a percentage of body weight | The area footprinted during gait was divided into 6 parts according to the average foot areas of subject. Then, the partial foot pressure as a percentage of body weight was calculated as the average value during the stance phase of each step in each part as a percentage of the body weight. | Baseline and up to 1 week after intervention | 
| Partial foot area as a percentage of body mass index | The area footprinted during gait was divided into 6 parts. The partial foot area as a percentage of body mass index was calculated as the average value during the stance phase of each step in each part as a percentage of the body mass index. | Baseline and up to 1 week after intervention | 
| Gait Cadence | the number of steps per minute | Baseline and up to 1 week after intervention | 
| Walking speed | the velocity of single step | Baseline and up to 1 week after intervention | 
| Single leg stance time | the time of the stance phase of each foot | Baseline and up to 1 week after intervention | 
| Step length | the distance between the first point of contact of a limb with the ground and the first point of contact of the limb on the opposite side | Baseline and up to 1 week after intervention | 
| Step width | the distance between the centre of the first heel contact and the following one calculated perpendicularly to the direction of the horizontal axis drawn between the feet | Baseline and up to 1 week after intervention | 
| Axis angle | the angle formed by the medial tangent of the foot and the line from the second/third toe to the center of the heel | Baseline and up to 1 week after intervention | 
| The Knee injury and Osteoarthritis Outcome Score | A questionnaire to assess the patient's opinion about their knee and associated problems. | Baseline and up to 1 week after intervention | 
| Sort Form-12v2 Healthy Survey | 12 question to measure functional health and well-being from the patient's point of view | Baseline and 1, 3, 6 month after intervention | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Knee osteoarthritis, Physical activity, Exercise