Home-HIT and Type 1 Diabetes

Study Overview
=================
Brief Summary
-----------------
This study aimed to use a multi-disciplinary approach to evaluate a 6-week home-based high-intensity interval training (Home-HIT) intervention in people with type 1 diabetes.

Detailed Description
-----------------
This study aimed to use a multi-disciplinary approach to evaluate a home-based high-intensity interval training (Home-HIT) intervention in people with type 1 diabetes. Eleven individuals with type 1 diabetes (4 men/7 women; age 30±3 years; BMI 27.1±1.2 kg·m-2; V ̇O2peak 32.4±2.1 ml∙kg∙min-1; duration of type 1 diabetes 10±2 years) completed six weeks of Home-HIT. The effect of Home-HIT on V ̇O2peak, blood pressure, insulin dose and glycaemic profile was assessed pre and post-training. Adherence and ability to meet target heart rate (HR) thresholds (compliance) were monitored using a HR monitor and mobile phone application. Change in glycaemia was measured pre, post and 1h post exercise sessions throughout the six-week period. A qualitative online survey was completed post-training. This is the first study to combine physiological outcomes with a qualitative evaluation of a training intervention in people with type 1 diabetes. Home-HIT resulted in high adherence alongside increased V ̇O2peak and decreased insulin dose. Because Home-HIT is time-efficient and removes barriers to exercise including fear of hypoglycaemia, it may represent an effective strategy to increase exercise participation in people with type 1 diabetes.

Official Title
-----------------
A Multi-Disciplinary Evaluation of Home-Based High-Intensity Interval Training in People With Type 1 Diabetes: A Pilot Study

Conditions
-----------------
Type1diabetes

Intervention / Treatment
-----------------
* Behavioral: Home-HIT


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: duration of type 1 diabetes >6 months, no significant history of hyper- or hypoglycaemia Exclusion Criteria: duration of type 1 diabetes <6 months, significant history of hyper- or hypoglycaemia, pregnancy or planning pregnancy, uncontrolled hypertension (>180/100 mmHg), angina autonomic neuropathy, taking any medication that affects heart rate (HR) major surgery planned within 6 weeks of the study severe nonproliferative unstable proliferative retinopathy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Training<br>6 weeks of home-based high intensity interval training | Behavioral: Home-HIT<br>* Participants completed 6 weeks of home-based high-intensity interval training 3 times per week<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in maximal aerobic capacity | Maximal aerobic capacity was measured pre and post 6 week training intervention using a MOXUS gas analyser on a stationary cycle ergometer | change in baseline maximal aerobic capacity at 6 weeks | 
| adherence over the course of the training programme | session completion rate (adherence) was assessed | adherence to the training programme over the course of the 6 week intervention | 
| Compliance over the course of the training programme | ability to meet target heart rates (compliance) was assessed | compliance to the training programme over the course of the 6 week intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in insulin sensitivity | insulin dose was recorded pre and post training by participants | change in baseline insulin sensitivity at 6 weeks | 
| change in glycaemic control | participants recorded their blood glucose concentrations in the first and final weeks of the intervention | change in baseline glycaemic control at 6 weeks |