Emotional Proactive Processing in Bipolar Disorder

Study Overview
=================
Brief Summary
-----------------
The main objective of this project is to identify behavioral specificities of the proactive emotional brain among bipolar patients, compared to healthy subjects. These could contribute to some of the emotional processing biases that can be observed in these patients. To achieve this goal, two behavioral tasks will be administer (emotional stroop and emotional stimuli categorization task) to bipolar patients and control subjects, and their performances will be compared.

Detailed Description
-----------------
This is a case-control non-interventional study comparing bipolar patients to matched healthy controls during one assessment visit at the University Hospital of Grenoble. The experimentation phase takes place in three stages: first, the experimenter collects demographic data (age and level of study, lack of medical history and treatments that may interfere with the task). For bipolar subjects, it also collects the type of bipolarity, the type and date of the last episode, the age of the onset of the disease and the treatment. Secondly, the subject performs a classic Stroop task lasting 3 to 5 minutes, including instructions. Finally, the subject performs the two main tasks: the emotional Stroop task lasting about 20 minutes and then the task of emotional stimuli categorization lasting about 15 minutes.

Official Title
-----------------
Emotional Proactive Processing in Bipolar Disorder

Conditions
-----------------
Bipolar Disorder, Bipolar I Disorder, Bipolar II Disorder

Intervention / Treatment
-----------------
* Behavioral: Emotional Stroop Task


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Right-handed Francophones Bipolar disorder diagnosis (for patients) according to DSM-5 / CIM-10 criteria Affiliation to the French social security insurance Exclusion Criteria: uncorrected perceptual disturbance psychiatric disorders other than bipolarity as the main psychiatric disorder or a condition which may affect the tasks proposed for the patients' group subject under legal protection subject deprived of freedoms by a judicial or administrative decision drug abuse less than 12 hours before the assessment

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Bipolar patients<br>Bipolar patients (type I,II, NOS) of the bipolar disorder expert center of CHU Grenoble Alpes. | Behavioral: Emotional Stroop Task<br>* Classic Stroop task The subject names one of the 3 colors of the crosses on a sheet.Then, the subject must read the words written on the sheet for 45 seconds.These are the words: RED, BLUE and GREEN, written in black color. The subject must name the color of the word. Emotional Stroop task This is a computed task in which the patient is asked to answer both as accurately and as quickly as possible. The target stimulus is an emotional face of joy or anger, surmounted by the word joy or anger.The subject must respond using the arrow corresponding to the face he sees. A training phase is offered to the subject. 3 / Categorization task For each trial the participant will visualize a short emotional film or not. Then, the participant will have to choose, the emotion corresponding to what he just saw. A training period is offered too.<br>* Other names: Categorization of Emotional Stimuli Task;|
| Healthy controls<br>Volunteers without any psychiatric disease matching inclusion criteria | Behavioral: Emotional Stroop Task<br>* Classic Stroop task The subject names one of the 3 colors of the crosses on a sheet.Then, the subject must read the words written on the sheet for 45 seconds.These are the words: RED, BLUE and GREEN, written in black color. The subject must name the color of the word. Emotional Stroop task This is a computed task in which the patient is asked to answer both as accurately and as quickly as possible. The target stimulus is an emotional face of joy or anger, surmounted by the word joy or anger.The subject must respond using the arrow corresponding to the face he sees. A training phase is offered to the subject. 3 / Categorization task For each trial the participant will visualize a short emotional film or not. Then, the participant will have to choose, the emotion corresponding to what he just saw. A training period is offered too.<br>* Other names: Categorization of Emotional Stimuli Task;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| performances at the emotional Stroop task | percentage of correct answers ( in %), reaction time ( in seconds) and inverse efficiency score ( N.A) | day1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| sensitivity to interference during Stroop tasks | -reaction time (in seconds) in the different conditions of the task (reading in the congruent condition, interference during the incongruent condition) | day1 | 
| Effect of mood state (depressive state) on behavioral tasks' performances | assessment of the impact of mood scales (MADRS) scores on behavioral tasks performances | day 1 | 
| Effect of mood state (hypo/manic state) on behavioral tasks' performances | assessment of the impact of mood scales (YMRS) scores on behavioral tasks performances | day 1 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
bipolar disorder, emotion, cognition, stroop, proactive emotional processing