A Observational Study to Compare Effectiveness and Safety of the Surgeries in Patients With Esophageal Cancer

Study Overview
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Brief Summary
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The study was designed to compare effectiveness and safety of the surgeries of Ivor-Lewis and Mckeown in patients with esophageal cancer

Detailed Description
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The trial is a multi-centre real-world non-interventional observational study. The study was designed to compare effectiveness and safety of the minimally invasive surgeries of Ivor-Lewis and Mckeown in the Chinese patients with IA-IIIB esophageal cancer via a retrospectively review method based on the study data on patient demographic/tumor biological characteristics and clinical treatments.

Official Title
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A Multi-centre Real-world Non-interventional Observational Study to Compare Effectiveness and Safety of the Minimally Invasive Surgeries of Ivor-Lewis and Mckeown in Chinese Patients With IA-IIIB Esophageal Cancer

Conditions
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Esophageal Cancer

Intervention / Treatment
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* Procedure: Surgeries


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Pathologically diagnosed middle and lower thoracic IA-IIIB esophageal cancer after surgeries; Patients who received minimally invasive radical dissections of Ivor-Lewis and Mckeown; Patients who received tubular gastroesophageal reconstruction; Exclusion Criteria: Patients complicated with arrhythmia, or serious disfunctions of heart, lung, liver, and kidney before surgeries; Patients with second primary tumors; Patients who received abdominal or thoracic surgeries; Patients who received gastrostomy or nesteostomy before surgeries; Patients with suspected cervical lymph metastases (in the subgroup of the patients who received the surgery of Mckeown)
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with the surgery of Ivor-Lewis<br>Pathologically diagnosed IA-IIIB patients with esophageal cancer who received minimally invasive surgery of Ivor-Lewis | Procedure: Surgeries<br>* Minimally invasive surgeries of Ivor-Lewis and Mckeown<br>|
| Patients with the surgery of Mckeown<br>Pathologically diagnosed IA-IIIB patients with esophageal cancer who received minimally invasive surgery of Mckeown | Procedure: Surgeries<br>* Minimally invasive surgeries of Ivor-Lewis and Mckeown<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall survivals in patients with esophageal cancer who received surgeries | Overall survivals in patients with esophageal cancer who received surgeries categorised by tumor biological characteristics | 2010 - 2017 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Death rates within 30 days after surgeries | Death rates within 30 days after surgeries categorised by tumor biological characteristics | 2010 - 2017 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Chinese, esophageal cancer, surgeries of Ivor-Lewis/Mckeown