Wound Additives in Primary Total Joint Athroplasty

Study Overview
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Brief Summary
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3 cohorts of total joint patient of 30 members each were randomized to receive PRP or Activated Collegen or no additive were studied for status of the wound at 6 weeks and recorded all complications, infections and reoperations. The three groups were than compared for statistical analysis

Detailed Description
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Background: Wound healing remains a concern in primary total joint arthroplasty given the risk of deep infections arising from hematomas, wound separations, and superficial infections. If wound additives can prevent these early complications, their universal application would be cost effective. This study examined whether two wound additives, Platelet-Rich Plasma (PRP) and CellerateRX® (activated collagen), would improve postoperative wound healing and reduce complications in primary total joint arthroplasty. Methods: A prospective, randomized, controlled study using three cohorts with 30 patients each (Group 1: PRP, Group 2: activated collagen, Group 3: control) were examined postoperatively at two and six weeks, at which time the following data were recorded: six wound measurements, total postoperative blood loss, complications of superficial infections, and reoperations.

Official Title
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The Effects of Platelet-Rich Plasma and Activated Collagen on Wound Healing in Primary Total Joint Arthroplasty

Conditions
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Arthroplasty, Replacement

Intervention / Treatment
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* Biological: Platelet Rich Plasma
* Biological: Cellerate


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Osteoathritis of knee and hip Exclusion Criteria: Inflammatory arthritis and hypercoagulable state

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: 3 groups with identical surgical closures randomized into 2 groups with wound additives and the third group without wound additives.
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Platelet Rich Plasma<br>30cc of PRP was administered at closure of wound | Biological: Platelet Rich Plasma<br> <br> * Other names: PRP;|
| Experimental: Cellerate (Activated Collegen)<br>1gm of Cellerate was administered at closure of wound | Biological: Cellerate<br> <br> * Other names: Activated college;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Wound Status | wound hematoma, dehiscence, superficial infection | 6 weeks post operative | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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total joint arthroplasty, platelet-rich plasma, activated collagen