Relationships and Differences Analysis in Heart Failure

Study Overview
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Brief Summary
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This study characterizes heart failure patients who attended the University Hospital Würzburg. The primary aim is a better understanding of the relationships and differences between the subgroups HFrEF (EF < 40%), HFmrEF (EF 40-49%), and HFpEF (EF>50%), contributing to an improved diagnosis, prognosis and therapy of patients with heart failure.

Detailed Description
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The varying clinical picture of heart failure (HF) represents a major challenge for patient care in Germany. HF is one of the most common reasons for hospitalization in the Western world. In the chronic course of heart failure, affected patients are committed to morbidity, lifelong therapy and high risk of cardiac decompensation, also associated with high mortality. Heart failure patients, who visited the Cardiology Department of the University Hospital Wuerzburg, shall be analyzed with regard to all clinical data and outcome. This retrospective work should help to better understand the three groups HFrEF (EF < 40%), HFmrEF (EF 40-49%) and HFpEF (EF>50%) and help identifying similarities and differences between the groups. Hereby we hope for progress in diagnostic, prognostic and therapeutic aspects of heart failure.

Official Title
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Retrospektive Datenanalyse Von Herzinsuffizienzpatienten in Der Kardiologie Des Universitätsklinikums Würzburg

Conditions
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Heart Failure, Chronic Heart Failure, Chronic Heart Disease

Intervention / Treatment
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* Other: Time (outcome)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis: Heart failure Minimum of two echocardiographic examinations in a minimum time frame of six months Patients must have reached the age of 18

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| HFrEF<br>HFrEF (Heart failure with reduced ejection fraction): ESC Guideline heart failure 2016: patients with LVEF < 40%. LVEF = Left ventricular ejection fraction | Other: Time (outcome)<br> <br> |
| HFmrEF<br>HFmrEF (Heart failure with mid-range reduced ejection fraction): ESC Guideline heart failure 2016: patients with LVEF 40-49%. LVEF = Left ventricular ejection fraction | Other: Time (outcome)<br> <br> |
| HFpEF<br>HFmrEF (Heart failure with preserved ejection fraction): ESC Guideline heart failure 2016: patients with LVEF > 50%. LVEF = Left ventricular ejection fraction | Other: Time (outcome)<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Long-term survival in heart failure patients with preserved, mid-range or reduced left ventricular ejection fraction | Survival of patients with heart failure extracted from medical record or by telephone interview | 1 year follow up after last examination | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Impact of clinical imaging and laboratory parameters on long-term survival in heart failure patients with precerved, mid-range or reduced left ventricular ejection fraction | Parameters are derived from standard echocardiography, cardiac magnetic resonance imaging and blood testing. | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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HFpEF, HFmrEF, HFrEF, Heart Failure