Motor, Non-motor and Genetic Determinants of Progression in Parkinson's Disease: A Mexican Multicenter Cohort Study

Study Overview
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Brief Summary
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The objective of the study is to assess the effect of motor, non-motor and genetic factors on the progression of Parkinson's disease as well as its impact on complications rates. A large sample of Mexican subjects with Parkinson's disease attending several referral centers will be included. Data collected will include disease severity and motor scales, non-motor scales as well as genotyping for monogenic forms of the disease. Assessments will be performed every 6 months for two years.

Detailed Description
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Demographic and clinical data will be collected after obtaining a signed informed consent. Recruitment will be competitive. Data collected includes age, gender, motor phenotype, age at onset, age at diagnosis, smoking history, family history, antiparkinsonic treatment, other treatments and a complete neurological evaluation.

Official Title
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Motor, Non-motor and Genetic Determinants of Progression and Complications in Parkinson's Disease: A Multicenter Cohort Study in Mexican Population (ReMePArk)

Conditions
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Parkinson's Disease

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis of Parkinson's disease by the United Kingdom Parkinson's disease Society Brain Bank Criteria Any gender Any Hoehn and Yahr stage Written informed consent Exclusion Criteria: Severe comorbidity that may limit proper neurological evaluation as judged by the investigator Subjects with atypical or secondary parkinsonism

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 95 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| PD Cohort<br>Subjects diagnosed with Parkinson's disease | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To assess motor scale change over time | Motor symptoms will be assessed by proper and validated motor scales; also minimal clinically important change will be determined. | Every 6 months for 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To assess non-motor symptoms over time | Non-motor symptoms will be assessed using proper validated scales. Frequency and severity will be recorded. | Every 6 months for 2 years | 
| To assess quality of life change over time. | Health-related quality of life will be assessed with proper validated clinimetric instruments. | Every 6 months for 2 years | 
| To assess caregiver burden as disease progresses | Caregiver burden will be assessed by proper validated scales. | Every 12 months for 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Parkinson's disease, Motor, Non-motor, Progression, Complications