Functional Magnetic Resonance Imaging (fMRI) Exploration of Neurocognitive Processes Involved in Food Addiction (FA) in Obese Patients: Towards New Phenotypic Markers for an Optimized Care Pathway

Study Overview
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Brief Summary
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Identification of the cerebral fMRI phenotype of obese patients with FA in cognitive task context based on food choice making

Detailed Description
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Obesity is a worldwide epidemic associated with many complications. The treatment of obesity is a failure if it does not take into account eating disorders. Among them, food addictions seem to be frequent among obese patients. Clinical diagnosis and therapeutic approaches depend on presence of these FA. Moreover, eating disorders are associated with visible brain abnormalities in fMRI but the cerebral fMRI phenotype of FA is not known.

Official Title
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Functional Magnetic Resonance Imaging (fMRI) Exploration of Neurocognitive Processes Involved in Food Addiction (FA) in Obese Patients: Towards New Phenotypic Markers for an Optimized Care Pathway

Conditions
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Obesity

Intervention / Treatment
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* Device: fMRI
* Device: Indirect calorimetry
* Device: Bioimpedance
* Biological: Lipid profile, glucose, HBA1c, metabolomic analysis
* Behavioral: YFAS questionnaire, Binge Eating Scale, Hospital Anxiety and Depression (HAD) scale, hedonic evaluation test (liking)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: female right-handed grade 1 and 2 obesity aged between 20 and 50 no other addictions including smoking no contraindications to fMRI affiliated to French Social Security having given a written informed consent Exclusion Criteria: abdominal circumference + upper limbs along the body > 200cm addiction to alcohol or other psychoactive substances daily smoker sleep Apnea Syndrome paired psychotic psychiatric disorders history of bariatric surgery medical care in the nutrition unit inability to comprehend or complete questionnaires pregnant or breastfeeding woman persons subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty.

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patient with food addcitions<br>Patients (20) will be selected from the Yale Food Addiction Scale (YFAS): a validated screening of FA questionnaire. Three clinical visits will be realized in less than two months | Device: fMRI<br>* Brain MRI<br>Device: Indirect calorimetry<br>* Resting energy expenditure<br>Device: Bioimpedance<br>* Measurement of body composition<br>Biological: Lipid profile, glucose, HBA1c, metabolomic analysis<br>* Blood sample<br>Behavioral: YFAS questionnaire, Binge Eating Scale, Hospital Anxiety and Depression (HAD) scale, hedonic evaluation test (liking)<br>* Questionnaires to characterize eating habits and depression<br>|
| Experimental: Patients without food addictions<br>Patients (20) will be selected from the Yale Food Addiction Scale (YFAS): a validated screening of FA questionnaire. Three clinical visits will be realized in less than two months | Device: fMRI<br>* Brain MRI<br>Device: Indirect calorimetry<br>* Resting energy expenditure<br>Device: Bioimpedance<br>* Measurement of body composition<br>Biological: Lipid profile, glucose, HBA1c, metabolomic analysis<br>* Blood sample<br>Behavioral: YFAS questionnaire, Binge Eating Scale, Hospital Anxiety and Depression (HAD) scale, hedonic evaluation test (liking)<br>* Questionnaires to characterize eating habits and depression<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Significant change in brain activity of the prefrontal cortex (area involved in the inhibitory control of food intake) measured by modification of BOLD (Blood-Oxygen-Level-Dependent) signal in fMRI during a cognitive task based on food choice making |  | Month 2 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Obesity, Food addictions, Functional magnetic resonance imaging (fMRI), Metabolomics