Adaptation of Melodic Intonation Therapy to Spanish

Study Overview
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Brief Summary
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This study was conducted in three phases: The first phase involved creation of a Spanish adaptation of the Melodic Intonation therapy; the second phase consisted of a pilot non-randomized intervention study to analyse its feasibility for use with 4 Spanish patients with poststroke nonfluent aphasia; the third phase consisted of a pilot randomised, crossover, intervention pilot trial in a different set of patients with poststroke nonfluent aphasia (N=20)

Official Title
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Adaptation of Melodic Intonation Therapy to Spanish: a Feasibility and Validation Pilot Clinical Trial

Conditions
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Post Stroke Aphasia

Intervention / Treatment
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* Other: Melodic Intonation Therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients diagnosed with nonfluent aphasia due to unilateral stroke in the left hemisphere without neuroimaging evidence of lesions in the right hemisphere who fulfilled the following criteria: The time elapsed since the stroke exceeded 6 months. Patient had received a standard program of conventional speech therapy after stroke. Persistent nonfluent aphasia with the following characteristics: Severely restricted language, which might be limited to meaningless stereotypy; unlike that observed in verbal tasks, the patient might produce some real and relevant words when singing familiar songs. Poor repetition, even for single words. Moderately preserved language comprehension. The nonstereotyped language was produced with a slurring of speech. The total score for the repetition did not exceed the 70th percentile in the Boston Diagnostic Aphasia Examination. The score was obtained from the average score in three areas: repetition of words and repetition of phrases; listening comprehension exceeding the 15th percentile of Boston Diagnostic Aphasia Examination; and from the average score obtained in three areas: word comprehension, commands and complex ideational material. The patient was motivated, emotionally stable and had good attention. Signed informed consent was provided. Exclusion Criteria: patients with a history of a previous stroke other than the index event or with any clinical condition (e.g., short life expectancy, coexisting disease) or other characteristics that precluded appropriate follow-up in the study patients participating in any therapeutic intervention clinical trials evaluating poststroke recovery use of psychotropic drugs that interfere with patient evaluation.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Melodic Intonation Therapy<br>The duration of therapy was 12 sessions performed over a 6-week period. Each session lasted 30 minutes. They were performed individually by a speech-experienced therapist previously trained in Melodic Intonation Therapy. | Other: Melodic Intonation Therapy<br> <br> |
| No Intervention: Waiting list<br>No intervention | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Communicative Activity Log questionnaire |  | 6 weeks after the end of therapy | 
| Boston Diagnostic Aphasia Examination |  | 6 weeks after the end of therapy | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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stroke, aphasia, melodic intonation therapy