linjc16/ctgov huggingface dataset:
Propofol Sedation vs. Anaesthetist Guided Anaesthesia in Oocyte Pickup

Study Overview
=================
Brief Summary
-----------------
Patients undergoing their first course of in vitro fertilisation receive either gynaecologist guided propofol only sedation or anaesthetist guided full anaesthesia. Patient satisfaction and clinical outcome will be evaluated afterwards.

Official Title
-----------------
Propofol Sedation vs. Anaesthetist Guided Anaesthesia in Oocyte Pickup - a Prospective Study

Conditions
-----------------
IVF

Intervention / Treatment
-----------------
* Drug: Propofol


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient undergoing first oocyte pickup Understands german language to fill out questionnaire Exclusion Criteria: BMI >30 BMI <17 Heavy endometriosis Patients undergoing a consecutive IVF attempt

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Propofol<br>Patients receive gynaecologist guided individualised propofol sedation | Drug: Propofol<br>* Gynecologist guided individualised propofol only sedation<br>|
| Active Comparator: Anaesthetic guided anaesthesia<br>Patients receive anaesthetist guided full anaesthesia | Drug: Propofol<br>* Gynecologist guided individualised propofol only sedation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient satisfaction | Patient satisfaction measured by the ZUF-8 questionnaire (Questionnaire to evaluate patient satisfaction) | May 2022-March 2023 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Retrieved oocytes | Number of retrieved oocytes | 1st of May 2022- 1st of March 2023 | 
| Mature oocytes | Number of mature oocytes | 1st of May 2022-1st of March 2023 | 
| Fertilised oocytes | Number of fertilised oocytes | 1st of May 2022- 1st of March 2023 | 
| Cryopreserved blastocysts | Number of cryopreserved blastocysts | 1st of May 2022- 1st of March 2023 | 
| Pregnancy rate | Pregnancy rate | 1st of May 2022- 1st of March 2023 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Oocyte Retrieval, Sedation
Identification of Difficulties During a First Request for a Personal Autonomy Allowance

Study Overview
=================
Brief Summary
-----------------
The objective of this study is to identify the difficulties when first applying for a first Resource Allocation (Personal autonomy allowance - APA) by beneficiaries and their relatives through a qualitative study and secondarily identification of the role of the attending physician during this request.

Detailed Description
-----------------
The APA, introduced since the French law of 2001 aims to improve the care of people with loss of autonomy. A regular assessment of autonomy in the elderly should be carried out in order to implement ABS as early as possible. The aim is to set up the necessary home help to avoid or delay institutionalisation. It therefore seems essential to place oneself on the side of the beneficiaries and their relatives in order to identify the difficulties encountered during a first ABS application and their expectations as to the role of the general practitioner during this application?

Official Title
-----------------
Identification of Difficulties During a First Request for a Personal Autonomy Allowance by Beneficiaries and Identification of the Role of the Attending Physician During This Request.

Conditions
-----------------
Persons Requesting a Resource Allocation (APA), Beneficiairies Requesting a Resource Allocation (APA)

Intervention / Treatment
-----------------
* Other: semi-structured interview


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Beneficiaries living in Ille et Vilaine requesting for the first time a Resource Allocation (APA) Or Persons requesting for the first time a Resource Allocation (APA) Allocation of resources for the benefit of a person residing in Ille et Vilaine Exclusion Criteria: Refusal of Resource Allocation opposition to participation in the survey.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: semi-structured interview|Semi-strucured interview to identify the difficulties when first applying for a personalised autonomy allowance by beneficiaries and their relatives|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Semi-structured interview | The interview guide will seek to make the beneficiaries talk about their administrative difficulties, access to information, coordination between medical and social professionals and others faced when making their first request for resource allocation (APA) | through study completion, an average of 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
personalised autonomy allowance, difficulties, physician's role
Child Results Following Preventive Children of Parents With Psychiatric and Addictive Problems (COPP) Groups

Study Overview
=================
Brief Summary
-----------------
This is a study evaluating changes in quality of life and global functioning across and after a manualized peer-group preventive intervention for children of parents with psychiatric or addictive problems.

Detailed Description
-----------------
Self-reported quality of life and based on the group-interviews ILK and Kindl and general adaptive functioning (CGAS) as reported by teachers and parents will be measured before, after and at follow-up relative to the manualized peer-group preventive intervention. Parents will also complete self-reports on anxiety and depressive symptoms, personality, bonding and attribution before the intervention.

Official Title
-----------------
Preventive Peer Groups for Children of Parents With Psychiatric and Addictive Problems (COPP). Child Experiences and Observed Child Changes Following the Intervention

Conditions
-----------------
Psychiatric Disorder NOS

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Family including Parent with psychiatric or addictive problems Exclusion Criteria: acute severe disorder

Ages Eligible for Study
-----------------
Minimum Age: 8 Years
Maximum Age: 110 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Parents with psychiatric or addictive problems
DNA of Oral Cytobrush in Three Means Conservation

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to analyze genomic DNA of buccal cytobrush stored in three means conservation.

Detailed Description
-----------------
Blood samples are an excellent source of large amounts of genomic DNA. However, alternative sources are often needed in epidemiological studies because of difficulties in obtaining blood samples.

Official Title
-----------------
Evaluation of Genomic DNA of Oral Cytobrush in Three Means Conservation

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Procedure: samples collected by buccal cytobrush


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy young Exclusion Criteria: none

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 33 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: buccal cytobrhsh<br>healthy young | Procedure: samples collected by buccal cytobrush<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
DNA, Buccal Mucosa, Polymerase Chain Reaction
Low-dose Gated CT Validity for the Evaluation of Ascendant Aortic Aneurysm.

Study Overview
=================
Brief Summary
-----------------
We will demonstrate the validity of measurements with a low-dose, EKG-gated CT without contrast in the ascending aorta evaluation, compared with the current Angio-CT measurements.

Detailed Description
-----------------
The actual protocol used in aorta evaluation consist of two CT-scans on the same study. The first scan that detects calcifications is using parameters with low-dose current, non EKG-gated and without contrast. The second scan uses iodine-contrast, EKG-gating and higher current dose to obtain higher image quality of diagnostic value. The study will optimize the first scan parameters and compare the measures of the aorta diameters from the standard protocol. By modifying the first scan parameters, we would demonstrate that the follow-up of an aortic aneurysm can safely be made with lower radiation exposure.

Official Title
-----------------
Low-dose, EKG-gated CT Validity for the Evaluation of Ascendant Aortic Aneurysm.

Conditions
-----------------
Ascendant Aortic Aneurysm

Intervention / Treatment
-----------------
* Other: Modified Low-dose, EKG-gated CT without contrast for the evaluation of aortic aneurysm


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 60 years old and more 85 bpm or less Exclusion Criteria: aortic material EKG gating not possible aorta pathology (thrombus, dissection)

Ages Eligible for Study
-----------------
Minimum Age: 60 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Subjects awaiting for an aortic evaluation<br>Subjects already waiting for an aortic evaluation, either a first diagnostic scan or follow-up of a known aneurysm. Each subjects will have the two CT-scans on the same day. | Other: Modified Low-dose, EKG-gated CT without contrast for the evaluation of aortic aneurysm<br>* On the same day, the subject will do : Modified low-dose, EKG-gated CT without contrast Usual high-dose, EKG-gated CT with contrast Comparing aortic diameters from the two protocols.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measures validity (aorta diameter in mm from scan images) | Comparing aorta diameters from the two modalities. | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Radiation (in msev from scanner report) | Comparing radiation exposure with the two modalities | 12 months |
The Effect of Drain Use on Patient Comfort in Laparoscopic Sleeve Gastrectomy

Study Overview
=================
Brief Summary
-----------------
Introduction Laparoscopic sleeve gastrectomy surgeon; Have become increasingly morbid obesity treatment methods with improvements in minimally invasive surgery. Ensuring patient comfort and early return to life are the criteria that should be given priority in this treatment method. The purpose of this study is to determine the use of drain, which closely affects these criteria; And the effect on patient comfort.

Detailed Description
-----------------
Question the necessity of routine use of drain in Laparoscopic sleeve gastrectomy surgeon

Official Title
-----------------
Effect of Drain Usage on Patient Comfort on Laparoscopic Sleeve Gastrectomy

Conditions
-----------------
Obesity, Morbid

Intervention / Treatment
-----------------
* Other: Drainage


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Morbid obese patients Exclusion Criteria: - Cirrhotic patients, those under 18 years of age, additional intraabdominal surgeries during Laparoscopic sleeve gastrectomy and those who had previously undergone obesity surgery (revision surgery) were excluded

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Drain replacement<br>Effects of drainage | Other: Drainage<br>* Using drain after operation<br>|
| No Intervention: Drain not placed<br>Effects of not using drain | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain Intensity measure | self reported pain intensity morning. item is scored 0-10 ( 0: no pain- 10: pain as bad as can be) | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
VAS, obesity, Pain, Laparoscopy, Sleeve
Ibuprofen-PC Compared With Ibuprofen in a GI Safety Trial

Study Overview
=================
Brief Summary
-----------------
To determine the safety and efficacy of 3 x 800 mg/day IBU-PC assessed by endoscopy and incidence of adverse events

Official Title
-----------------
Phase II, Randomized, Blinded Study of Ibuprofen-PC and Ibuprofen in Patients With Osteoarthritis to Investigate Efficacy and Gastrointestinal Toxicity

Conditions
-----------------
Osteoarthritis

Intervention / Treatment
-----------------
* Drug: Ibuprofen-PC


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: moderate osteoarthritis in the hip and/or knee requiring chronic pain medication others per protocol Exclusion Criteria: sensitivity to NSAIDs and lecithin hypertension history of GI and other specific problems use of medications and other criteria per the protocol

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Ibuprofen-PC|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lanza score assessed by endoscopy at baseline and after six weeks of treatment to measure GI safety. |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| WOMAC and VAS scores every two weeks until end of treatment to measure efficacy. |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
NSAID-PC, IBU-PC
Collection of Whole Blood Specimens in Pregnant Women

Study Overview
=================
Brief Summary
-----------------
To prospectively collect whole blood specimens and clinical data from pregnant women scheduled for an invasive prenatal diagnostic procedure (invasive procedure). Specimens will be used for future testing with an investigational NIPT.

Detailed Description
-----------------
This is a prospective multicenter study in which whole blood specimens will be collected from pregnant women scheduled for an invasive procedure. After the standard-of-care invasive procedure is performed in accordance with the site's clinical procedures, invasive prenatal diagnostic procedure results will also be collected.

Official Title
-----------------
Prospective Collection of Whole Blood Specimens in Pregnant Women

Conditions
-----------------
Pregnancy Related

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Be 18 years of age or older at enrollment, Has a viable pregnancy (with documented fetal heartbeat) of at least 10 weeks, 0 days gestation at the time of maternal specimen collection, Be scheduled for an invasive prenatal diagnostic procedure (either chorionic villus sampling [CVS], amniocentesis, or percutaneous umbilical cord blood sampling [cordocentesis]) for cytogenetic analysis of the fetus Exclusion Criteria: Has a known maternal chromosomal anomaly, Had an invasive prenatal diagnostic procedure in the current pregnancy before maternal specimen collection Has a history of transplant or malignancy, or Had a transfusion of blood or blood components up to 8 weeks before maternal whole blood specimen collection Already participated in this study (enrolled previously).

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Subject is scheduled for an invasive procedure and did not have NIPT testing in current pregnancy | |
| 2<br>Subject is scheduled for an invasive procedure and has a known positive or no-call result from a targeted NIPT in the current pregnancy | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Collect Whole Blood Specimens in Pregnant Women | To collect maternal whole blood specimens from approximately 5,150 women with corresponding cytogenetic results from invasive prenatal diagnostic procedures (performed per the standard of care) to achieve sample size goals | 3 years |
Study of Hemostasis in Case of Severe COVID-19

Study Overview
=================
Brief Summary
-----------------
The COVID-19 outbreak has led to a significant increase in the number of patients admitted to intensive care for respiratory distress. Early data indicate a particularly high risk of thrombotic risk to viral lung disease, particularly in the most severe patients, with a particularly high incidence of pulmonary embolism. Catheter thrombosis and extra-renal purification filters are also abnormally common. These thrombotic complications could contribute to the mortality observed in this pathology. The introduction of early curative anticoagulation in the most severe patients has just been proposed by the perioperative hemostasis interest group Biologically, a significant proportion of patients hospitalized in intensive care have a marked biological inflammatory syndrome, associated with signs of activation of clotting (a frank increase in D-dimers). The presence of circulating anticoagulants is common. Interestingly, thrombocytosis, normally observed in such inflammatory syndromes, is absent. In this context, it seems legitimate to explore these patients from a hemostasis perspective to identify the factors that cause this thrombotic over-risk, in order to minimize the occurrence of these complications.

Official Title
-----------------
Study of Hemostasis in Case of Severe COVID-19

Conditions
-----------------
COVID-19 Infection

Intervention / Treatment
-----------------
* Other: Extra blood sample


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult patient (<18y) With a SARS-CoV-2 infection confirmed by RT-PCR Hospitalized in intensive care Exclusion Criteria: Patients under guardianship/curator Anemia at 7 g/dL at inclusion

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Extra blood sample|3 extra blood samples at day 0, 2 and 7|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Platelet activation intensity with the occurrence of clinical thrombotic complications |  | Change of platelet activity from admission's day in intensive care unit to 2 days and 7 days |