CT in Calcified Coronary Arteries With Photon Counting Detector

Study Overview
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Brief Summary
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Coronary CT angiography is challenging in patients with more than mildly calcified coronary vessels, because of calcium artefacts that prevents evaluation of the lumen. The purpose of the CCT-PCD-1-study is to evaluate the diagnostic accuracy and image quality in coronary CT angiography using a commercially available CT system equipped with a photon counting detector technology. Patients referred for cardiac CT and conventional coronary angiography as part of routine preoperative evaluation before Transcatheter Aortic Valve Implantation (TAVI) will be asked for inclusion in the study. This group of patients has generally a coronary artery calcium burden and perform cardiac CT and coronary angiography as part of routine care. The diagnostic accuracy concerning significant coronary artery stenosis on the preoperative CT will be evaluated with the conventional coronary angiography as reference. Also, CT examination image quality will be evaluated.

Official Title
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CT av förkalkade kranskärl Med fotonräknarteknik

Conditions
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Coronary Stenosis, Calcific Coronary Arteriosclerosis

Intervention / Treatment
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* Diagnostic Test: Cardiac CT with photon counting detector


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients referred for cardiac CT AND conventional coronary angiography as part of routine preoperative evaluation. Exclusion Criteria: <65 years old. Heart arrhythmia. Heart rate >90/min with contraindication against beta blockers. Not capable of giving informed consent eGFR <30 mL/min/1.73m2

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Coronary CT<br>The single cohort consists of all patients enrolled in the study. All participants performs cardiac CT and coronary angiography as part of routine care. | Diagnostic Test: Cardiac CT with photon counting detector<br>* Cardiac CT including the coronary arteries. The cardiac CT is performed in routine care for the included patients.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnostic accuracy of CT concerning coronary stenosis with conventional angiography as reference | Coronary angiography with or without FFR is performed as part of routine care for included patients. The outcome measure is the agreement between coronary CT and coronary angiography. | 1 day. (Coronary angiography is usually performed the same day as cardiac CT.) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Image quality | Image quality on CT examination according to European guidelines on quality criteria for computed tomography | 1 day. (Image quality is assessed on the performed examination) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cardiac Computed Tomography, Photon Counting Detector