linjc16/ctgov huggingface dataset:
Study of Hypothalamic Metabolism in Spontaneous Cluster Headache Attacks

Study Overview
=================
Brief Summary
-----------------
Cluster headache is characterized by unilateral excruciating head pain and autonomic dysfunction. Hypothalamic overactivity was observed in nitrate-induced cluster-headache and in only one case of spontaneous cluster headache 'Sprenger et al, 2004). This prompted the application of hypothalamic deep brain stimulation. The aim of this data is to precise the localisation of the hypothalamic activation.

Official Title
-----------------
Study of Hypothalamic Metabolism in Spontaneous Cluster Headache Attacks

Conditions
-----------------
Cluster Headache

Intervention / Treatment
-----------------
* Procedure: position emission transaxial tomography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: cluster headache in crisis no serious illnesses in progress as cancer, autoimmune disease, liver disease patient without chronic psychiatric disease excluding moderate and reactional depression no demential disease no anxious or depressive disease no contraindication to PET scan (pregnancy and breast-feeding) social security cover written informed consent Exclusion Criteria: No effective contraception taken unable to realize a decubitus of 15 minutes long

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: position emission transaxial tomography|cerebral position emission transaxial tomography using 18Fluorodeoxyglucose|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To confirm the existence of a hypothalamic promoter at the origin of Spontaneous Cluster Headache Attacks |  | 2 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Comparison of a spontaneous acute cluster headache attack and rest (no pain) in ten patients with cluster headache defined with IHS criteria
School-Based Mental Health Program Implementation in Uganda

Study Overview
=================
Brief Summary
-----------------
Implementation of an adapted ParentCorps program in Ugandan schools will improve school mental health service resources, teachers' knowledge about child mental health, and teachers' classroom behavioral management and parent involvement skills.

Detailed Description
-----------------
Participating schools are randomly assigned to a 6-month long school-based intervention or to a wait-list control group. The intervention focuses on improving teacher's classroom behavioral management practices, parent engagement, and child mental health knowledge. Teachers are assessed at the beginning and the end of the study, and again after 6 months of intervention. Teachers' parent engagement, mental health knowledge, and behavioral practices in the classroom are assessed through observations and teacher ratings.

Official Title
-----------------
Implementing a School-based Mental Health Prevention Program in Ugandan Schools

Conditions
-----------------
Teacher Mental Health Knowledge, Teacher Skills in Addressing Child Mental Health Problem

Intervention / Treatment
-----------------
* Behavioral: ParentCorps


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Early childhood teachers Exclusion Criteria: Not early childhood teachers

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: ParentCorps<br>Teachers from Intervention schools will receive ParentCorps training and support. | Behavioral: ParentCorps<br> <br> |
| No Intervention: Wait List Control<br>Teachers from control schools will not receive training and support in Year 1, but will receive training and support in Year 2. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of School Teacher Behaviors | Teacher classroom behavioral management skills and parent engagement practices will be measured | Outcome will be measured 3 times--before interveniton, after intervention (about 6 month after the baseline assessment), and 6-month post intervention (about 6 months after the 2nd evaluation) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
school-based program, mental health, implementation
Chronic Knee Pain Study

Study Overview
=================
Brief Summary
-----------------
Specific Aims: 1) To examine differences between AA and white patients with knee OA in willingness to consider knee joint replacement. 2) To examine the relationship between socio-cultural factors and patient willingness to consider joint replacement. 3) To examine how demographic, socio-cultural, and clinical factors mediate the relationship between race and patient willingness. 4) To examine the relationship between patient willingness and referral to orthopedic care for knee OA (secondary aim). Experimental design/Methodology: A cross-sectional survey study design will be used to examine socio-cultural and clinical factors that may vary by race/ethnicity and may be determinants of willingness to consider joint replacement as a treatment option. Patients with symptomatic and radiographic knee OA from the primary care clinics will be surveyed. Only individuals with knee OA of sufficient severity that would be considered candidates for joint replacement will be included. Analytic strategies include ordinal logistic regression, path analysis, and regression trees. Subject population: The study sample will consist of approximately 133 African American and 419 white patients with OA of the knee in a primary care setting.

Official Title
-----------------
Disparity in Joint Replacement: Pathway to Intervention

Conditions
-----------------
Knee Osteoarthritis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: over age 50 chronic knee pain radiographic evidence of knee OA Exclusion Criteria: previous joint replacement inflammatory arthritis

Ages Eligible for Study
-----------------
Minimum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Knee OA<br>Those over the age of 50 who have frequent pain in their knee that has lasted for at least six months. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Compared to whites, AAs with knee OA will be less willing to consider joint replacement. Logistic regression will be used to model the categorical measure of willingness, if preliminary analyses indicate dichotomizing this measure. |  | Study Completion |
A Study to Evaluate Glucose and Insulin Response to Nutralin

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate how an investigational food product affects a healthy person's blood sugar and insulin levels.

Detailed Description
-----------------
The investigational food product has helped decrease the amount of insulin needed in treating diabetic dogs and has improved the dogs' longevity and quality of life. Observational analysis by trained veterinarians has indicated that the natural fluctuations in blood glucose levels do not exist in dogs using the product. The hypothesis for this study is that healthy human subjects will have an increase in insulin levels after consuming the investigational food product.

Official Title
-----------------
A Study to Evaluate Glucose and Insulin Response to Nutralin

Conditions
-----------------
Diabetes

Intervention / Treatment
-----------------
* Dietary Supplement: Nutralin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Men and women who are at least 18 years of age Non-diabetic Exclusion Criteria: Diabetes Women who are pregnant, breastfeeding or planning to become pregnant Current and active liver or kidney disease Any food allergies Celiac disease

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Nutralin<br>All 10 subjects in the study will consume the investigational food product. | Dietary Supplement: Nutralin<br>* Food product to be taken 15 minutes prior to each of the three main meals of the day.<br>* Other names: No other names at this time.;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glucose blood level | Measure the change in blood sugar levels | 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dosage of Insulin | Measure the levels of insulin | 4 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
diabetes, insulin, blood sugar
Association Between Active Transport and Acute Myocardial Infarction

Study Overview
=================
Brief Summary
-----------------
This study aims to investigate the association between active transport and the incidence of acute myocardial infarction in England.

Detailed Description
-----------------
This is a cross sectional ecological study using aggregated data from the existing Myocardial Ischaemia National Audit Project between 2010 and 2013. Data on active transport according to local authority was obtained from the UK 2001 and 2011 census, whilst important confounders including deprivation levels, prevalence of obesity and population smoking estimates were obtained from Public Health England. In addition to investigating the association between active transport and AMI, we also studied the extent to which the components of active transport, cycling and walking, were associated with AMI, and investigated whether any associations were contingent on a time lag effect between the dates of exposure to active transport and indecent AMI.

Official Title
-----------------
Association Between Active Transport and Acute Myocardial Infarction: Cross Sectional Ecological Study Using National Registry and Census Data

Conditions
-----------------
Acute Myocardial Infarction

Intervention / Treatment
-----------------
* Behavioral: Active Transport


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All cases of acute myocardial infarction recorded in MINAP between 2003 and 2010 Exclusion Criteria: Cases aged <16 and >64 years

Ages Eligible for Study
-----------------
Minimum Age: 16 Years
Maximum Age: 64 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Active Transport|Active transport, most commonly walking or cycling, is the use of physical activity to commute.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acute myocardial infarction | Admissions for acute myocardial infarction as recorded in MINAP | 2010 to 2013 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
active transport, cycling, walking
The Effectiveness of an On-line Training Program on Hospital Medical Staff to Improve Fire Knowledge

Study Overview
=================
Brief Summary
-----------------
Objective: To investigate the effectiveness of an online training program on medical staff in five public hospitals located in Sichuan, Yunnan, Hubei, and Fujian Provinces of China, on improving fire knowledge. Methods: Participants will be randomly divided into control (receiving non-fire video training) and intervention (receiving hospital fire video training) groups. All participants will complete a questionnaire of fire knowledge before and after receiving the training. Hypothesis: If the online training is effective, it can be promoted as a convenient and effective use of training and be promoted to other hospitals.

Official Title
-----------------
The Effectiveness of an On-line Training Program on Hospital Medical Staff to Improve Fire Knowledge

Conditions
-----------------
Fire

Intervention / Treatment
-----------------
* Behavioral: Hospital fire video training
* Behavioral: Non hospital fire video training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Physicians or nurses working in the recruiting hospitals Exclusion Criteria:

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 59 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention<br>Will receive hospital fire video training | Behavioral: Hospital fire video training<br>* Participants will watch a video about hospital fire training which last for 30 minutes<br>|
| Placebo Comparator: Control<br>Will receive non-fire video training | Behavioral: Non hospital fire video training<br>* Participants will watch a video about volcanic eruption which last for 30 minutes<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of fire knowledge | A 46-item multiple-choice questionnaire will be administered to measure the fire knowledge level of the participants. Sample items include Use a wet towel to cover your nose and mouth when fire occurs and How to assist patients with intravenous infusion to escape?. | Participants will complete the questionnaire 5 minutes before the start of and 1 minute after watching the video which last for 30 minutes, and the change of fire knowledge will be computed. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Disaster, Training
Observational Study to Develop Dosing Chart

Study Overview
=================
Brief Summary
-----------------
To confirm the predictors based on patient specific characteristics and ovarian response and develop dosing chart when Follitrope™ PFS is administered to infertility women patients.

Official Title
-----------------
A Multicenter, Prospective Cohort Observational Study to Develop Dosing Chart Based on Patient Specific Characteristics and Ovarian Response When Follitrope™ PFS is Administered Subcutaneously to Infertility Women Patients

Conditions
-----------------
Infertile Women Undergoing IVF or ICSI

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Female aged of 19 to 39 years Mean menstrual cycle in 25 to 35 days Patients to whom Follitrope PFS will be administered in those scheduled to undergo the IVF-ET according to the GnRH agonist or antagonist protocol In the past continuous IVF cycle failure less than 2 times Exclusion Criteria: Patients having a history of ovarian, breast, uterus, hyperthalamus, or pituitary tumor Abnormal uterine bleeding of undetermined origin Prior hypersensitivity to a component of recombinant FSH Ovarian cyst or enlargement of undetermined origin Clinically significant endocrine abnormalities Patients having polycystic ovary syndrome (PCOS) history Poor Ovarian responder (Bologna criteria) Patients who received Clomiphene citrate, Letrozole (Pemara), or Gonadotropin within 30 days prior to enrollment in this study

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 39 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| FSH only<br>GnRH agonist protocol & GnRH antagonist protocol | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| No. of oocytes retrieved No. of oocytes retrieved Number of oocyte retrieved | Number of oocyte identified by ovum pick up (OPU) after overovulation | after OPU, normally 2 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Oocyte maturity quality | Metaphase II oocytes (%, ICSI only) | after OPU, normally 2 weeks | 
| Total dose (IU) of Follitrope™ PFS administered |  | 2 weeks | 
| Total duration (days) of Follitrope™ PFS administered |  | 2 weeks | 
| E2 concentration on hCG day |  | normally 10 days | 
| P4 concentration on hCG day |  | normally 10 days | 
| Fertilization rate |  | 1 2 days after OPU | 
| Number of embryo transferred |  | 3 5 days after OPU | 
| Implantation rate |  | 24 days after OPU | 
| Biochemical pregnancy rate |  | 10 days after OPU | 
| clinical pregnancy rate |  | 24 days after OPU | 
| pregnancy rate |  | up to 10 weeks after OPU |
Arterial Calcifications in Nocturnal Hemodialysis and Renal Transplantation Versus Conventional Dialysis

Study Overview
=================
Brief Summary
-----------------
Objective: To assess whether nocturnal hemodialysis and renal transplantation are associated with less progression of coronary arterial calcification, compared with conventional hemodialysis and peritoneal dialysis; To identify the risk factors for coronary arterial calcification in dialysis and transplant patients, and to assess a possible interaction with treatment modality.

Detailed Description
-----------------
To assess whether nocturnal hemodialysis and renal transplantation are associated with less progression of coronary arterial calcification, compared with conventional hemodialysis and peritoneal dialysis; To identify the risk factors for coronary arterial calcification in dialysis and transplant patients, and to assess a possible interaction with treatment modality.

Official Title
-----------------
Is Progression of Arteriosclerosis in ESRD Patients Inhibited by Nocturnal Hemodialysis or Renal Transplantation?

Conditions
-----------------
Kidney Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: ESRD current age > 18 and < 75 yr ability to understand the study procedures willingness to provide written informed consent Exclusion Criteria: life expectancy < 3 months claustrophobia allergy to iodinated contrast treatment incompliance, i.e. non-adherence to dialysis regimens and drug use GFR < 30 ml/min (according to MDRD formula) in renal transplant patients pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| hemodialysis<br>patients treated with conventional hemodialysis | |
| peritoneal dialysis<br>patients treated with peritoneal dialysis | |
| nocturnal hemodialysis<br>patients treated with frequent nocturnal hemodialysis | |
| kidney transplantation<br>patients treated with renal transplantation | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in coronary artery calcification score | The coronary artery calcification score is measured in Agatston units or cubic millimeters and ranges from zero to theoretically infite. This coronary artery calcicifcation score is a total score for all coronary arteries. A higher score, and thus a higher increase in coronary artery calcification score, therefore represents a worse outcome. | 3 yrs | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cardiovascular disease, endstage renal disease