Corneal Endothelium After Glaucoma Surgery

Study Overview
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Brief Summary
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The purpose of this trial is to study the change in corneal endothelial cell after glaucoma surgery, non-contact specular microscopic examination is performed for the patients who underwent glaucoma surgery; trabeculectomy and Ahmed glaucoma valve implant surgery prospectively. Change in corneal endothelial cell density, hexagonality, and coefficient of variation of cell area will be analyzed and compared to the baseline and between the types of the surgeries.

Detailed Description
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To study the change in corneal endothelial cell after glaucoma surgery, non-contact specular microscopic examination is performed for the patients who underwent glaucoma surgery; trabeculectomy and Ahmed glaucoma valve implant surgery prospectively. Specular microscopy using non-contact type specular microscope (Noncon Robo SP-8000, Konan Medical Inc., Tokyo, Japan) was performed by one experienced examiner before surgery and 1, 6, 12, 18, and 24 months after surgery. All examinations were done at the center, superior, superonasal, and superotemporal area of the cornea, while the patient maintain fixation at the target in the equipment. The follow-up was stopped if serious complication requiring surgical treatment was developed or additional intraocular pressure lowering surgery is needed, and the data before the second surgery were collected.

Official Title
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Change in Corneal Endothelium After Glaucoma Surgery; Trabeculectomy and Glaucoma Implant Surgery

Conditions
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Glaucoma, Corneal Damage, Intraocular Pressure

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who need glaucoma surgery for intraocular pressure control Exclusion Criteria: congenital glaucoma Pre-existing corneal abnormality lost from follow up without any ocular problem within 6 months from surgery

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control<br>Eyes with glaucoma and on anti-glaucoma medication but without glaucoma surgery | |
| Implant surgery<br>Eyes underwent Ahmed glaucoma valve implantation | |
| Trabeculectomy<br>Eyes underwent conventional trabeculectomy with mitomycin-C | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in corneal endothelial cell density, hexagonality, and coefficient of variation of cell area |  | 1 and 2 years longitudinal follow up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical factors associated with the damage of corneal endothelium after glaucoma surgery |  | 1 and 2 years longitudinal follow up | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Corneal endothelial cell, Specular microscopy, Glaucoma implant surgery, Ahmed glaucoma valve, Trabeculectomy