The Impact of Pharmacist-led Mobile Application on Adherence in Chronic Kidney Disease Patients

Study Overview
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Brief Summary
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The aim of the study is to assess the impact of pharmacist led mobile application on adherence and efficacy of medication in chronic kidney disease patients

Detailed Description
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This is a prospective randomized two group pharmacist-led interventional study that will be conducted in a private nephrology clinic. The study will involve introduction of the mobile phone applications to chronic kidney disease patients to improve their adherence to the prescribed medications. Recruited patients will be randomly divided in two groups; intervention group and control group, with baseline evaluation of outcomes to be measured. Control group will be provided with usual care. Intervention group will be provided in addition to the usual care, with an access to the mobile application after a simple training for app usage. Both groups will be followed for a period of 3 months. The study will include the development, validation and the testing for evaluating the specially designed mobile application.

Official Title
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The Impact of Pharmacist - Led Mobile Application on Medication Adherence and Efficacy in Chronic Kidney Disease Patients

Conditions
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Chronic Kidney Diseases, Adherence, Medication

Intervention / Treatment
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* Other: Mobile Application


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Stages 2-5 of chronic kidney disease Literate Ownership of android smart phone compatible with the application Poly-pharmacy Exclusion Criteria: On dialysis due to loss of kidney function Pregnancy due to altered physiology

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control Group<br>Control group will be provided with usual care. Intervention group will be provided in addition to the usual care, with an access to the previously described mobile application | |
| Experimental: Intervention Group<br>Intervention group will be provided in addition to the usual care, with an access to the mobile application | Other: Mobile Application<br>* mobile phone applications directed to chronic kidney disease patients to improve their medication.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in medication adherence | Using a medication adherence questionnaire. | Change from baseline at 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in estimated glomerular filtration rate/ creatinine clearance | Calculated using serum creatinine lab results obtained from clinic. | Change from baseline at 3 months | 
| Change in systolic and diastolic blood pressure | To be measured in clinic. | Change from baseline at 3 months | 
| Change in HbA1c | Lab results obtained from clinic. | Change from baseline at 3 months | 
| Change in mobile application usability and acceptability by patients | Using System Usability Scale (SUS) questionnaire. (scale 0-100 with higher score meaning better usability) | Change from baseline at 3 months |