Cost of Illness Associated With Influenza in the UK

Study Overview
=================
Brief Summary
-----------------
The objective of this study is to describe the burden associated with influenza in the UK, from both primary and secondary care perspectives, and to stratify the burden by the annual degree of mismatch between predicted and actual virus strains.

Detailed Description
-----------------
This is a retrospective, cross sectional, exploratory, observational study using database analysis and therefore there is no patient or user group involvement.

Official Title
-----------------
The Cost of Illness Associated With Influenza in the UK

Conditions
-----------------
Influenza

Intervention / Treatment
-----------------
* Other: Data collection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male or female patients coded within the database as having acute respiratory events that could be related to an infection between 2001 and 2009. Patients must have a minimum of 14 days observation before and after the index event to permit the capturing of complications attributable to influenza. Exclusion Criteria: Not Applicable

Ages Eligible for Study
-----------------
Minimum Age: 5 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cohort Group<br> | Other: Data collection<br>* Data of patients diagnosed with acute respiratory illness is extracted from General Practice Research Database (GPRD), Hospital Episode Statistics (HES), the Health Protection Agency (HPA), Office of National Statistics (ONS), and National Health Service (NHS) Reference Costs, during the period January 21st 2001 and March 31st 2009 inclusive. All analyses of primary care data (GPRD) and separately for secondary care (HES) data will be repeated for all eligible patients, and the subset of patients with a linkage to additional data (HES, ONS). All analysis including secondary care data will be restricted to the subset of patients with linked HES data. Estimates of average burden per patient and total burden in the UK will be performed. Burden is defined as both resource use and cost. Annual incidence and burden will be calculated.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of influenza-related events |  | Over the study time period (from January 21st 2001 to March 31st 2009 inclusive) | 
| Number of confirmed influenza infections |  | Over the study time period (from January 21st 2001 to March 31st 2009 inclusive) | 
| Assessment of resource use |  | Over the study time period (from January 21st 2001 to March 31st 2009 inclusive) | 
| Evaluation of patient outcomes, treatments and costs (type and duration) |  | Over the study time period (from January 21st 2001 to March 31st 2009 inclusive) | 
| Cause of deaths |  | Over the study time period (from January 21st 2001 to March 31st 2009 inclusive) | 
| Incidence of influenza-related events in High Risk groups |  | Over the study time period (from January 21st 2001 to March 31st 2009 inclusive) | 
| Incidence of complications and exacerbations |  | Over the study time period (from January 21st 2001 to March 31st 2009 inclusive) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
UK, Illness, Influenza, Cost