Driving Ability in Patients With CMT 1A

Study Overview
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Brief Summary
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Charcot Marie Tooth 1A (CMT 1A) is a common inherited disorder of the nerves in the body. The disease can result in difficulties with strength and balance as well as in foot deformities such as high arches, hammer toes, and tight ankles. Because of these difficulties, the disease may affect driving, especially because driving requires quick responses at times such as slamming on the brakes or turning the steering wheel quickly. The following study determines driving performance in individuals who have CMT 1A.

Detailed Description
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Individuals with CMT 1A will drive in a driving simulator, which involves a car located in a room in the University of Iowa Hospitals and Clinics (UIHC). Individuals will drive in the car as if they are driving in real life and the whole experience is like playing a car video game with a big animated screen. The driving results will be compared to similar aged patients who don't have CMT 1A and have also taken the driving test. If patients with CMT 1A do have driving difficulties compared to those who do not have CMT 1A, the results of the study will try to help patients with CMT1A drive better by ultimately creating devices that might help them use the steering wheel or brake pedal in a safer way.

Official Title
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Driving Ability in Patients With CMT 1A

Conditions
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CMT 1A

Intervention / Treatment
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* Device: UIHC Driving Simulator


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Have CMT 1A Have a valid driver's license Exclusion criteria: History of other types of neuropathy (other than CMT 1A) History of blindness, seizures, or stroke, dementia/cognitive dysfunction

Ages Eligible for Study
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Minimum Age: 16 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: CMT 1A Group<br>Patients with CMT 1A will undergo a driving simulation study. The intervention will be the SIREN driving simulator. | Device: UIHC Driving Simulator<br>* This is a driving simulator located in the basement of the hospital. A car will be facing a large video screen of a driving simulation.<br>* Other names: SIREN Driving Simulator;|
| Active Comparator: Control Group<br>Patients without CMT 1A who are our normal controls will undergo a driving simulation study. The intervention will be the SIREN driving simulator. | Device: UIHC Driving Simulator<br>* This is a driving simulator located in the basement of the hospital. A car will be facing a large video screen of a driving simulation.<br>* Other names: SIREN Driving Simulator;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Driving Error Rate |  | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Deceleration speed |  | 1 year | 
| Time to braking |  | 1 year | 
| Time to apply steering maneuvers |  | 1 year |