Clinical Impacts of Oral Gastrografin Follow Through in Adhesive Small Bowel Obstruction (SBO)

Study Overview
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Brief Summary
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Mini abstract : Altogether 100 patients with 117 episodes of ASBO were randomized into control and gastrografin groups. Eight episodes in eight patients were excluded. Gastrografin group showed a significant decrease of both the time between admission and operation and that of hospital stay .The need for surgery was reduced but statistically insignificant.

Detailed Description
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Abstract Background: Many published studies have shown that Gastrografin can be used for diagnosis post operative acute small bowel obstruction (ASBO) and assessing the need for surgical intervention .However,the studies have reported conflicting results hence the aim of our study to test this hypothesis. Patients and methods : Altogether 100 patients with 117 episodes of ASBO were randomized into control and gastrografin groups in a double blinded fashion. Eight episodes in eight patients were excluded due to protocol violation. In Gastrografin group,100 ml of the dye administered through a nasogastric tube and complete obstruction has been considered if the contrast failed to reach the colon on the 24-hour film. Patients were operated on only if they developed signs of strangulation or failed to improve within 48 hours.

Official Title
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Clinical Impacts of Oral Gastrografin Follow Through in Adhesive Small Bowel Obstruction (SBO).

Conditions
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Small Bowel Obstruction

Intervention / Treatment
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* Other: Oral Gastrografin
* Other: Nothing per os


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients admitted to our surgical department by postoperative SBO were considered for inclusion in this trial. Exclusion Criteria: Age less than 18 years Large bowel obstruction Recent (within 4 weeks) abdominal surgery Ileus Cancer peritonitis Peritonitis Strangulation symptoms and signs Obstructed abdominal wall or groin hernia Subtotal or total colectomy All patients in whom the final diagnosis was not SBO

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1<br>Gastrografin group | Other: Oral Gastrografin<br>* 100 ml of the dye administered through a nasogastric tube<br>* Other names: oral contrast;|
| Placebo Comparator: 2<br>Control group | Other: Nothing per os<br>* A nasogastric tube<br>* Other names: no oral contrast;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| resolving |  | 48 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| non resolving |  | 48 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Adhesions, Oral contrast, Exploration