Effect of Weight Loss and Exercise on Liver and Muscle Fat in Obese Elderly

Study Overview
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Brief Summary
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The purpose of this study is to determine the effect of weight loss and exercise on liver and muscle fat.

Detailed Description
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Obesity causes serious medical complications and impairs quality of life. Moreover, both aging and obesity cause metabolic and physical dysfunction. The primary objectives of the proposed research are to evaluate the independent and combined effects of weight loss and exercise on Intrahepatic and Intramyocellular fat in obese elderly men and women. The central hypothesis is that in obese elderly subjects, weight loss will improve metabolic and physical function while the addition of exercise will not only augment improvement in these outcomes, but also attenuate the adverse effects of weight loss on bone and muscle masses. To test this hypothesis, 20 elderly (65-85 years old) obese men and women (body mass index [BMI] > 30 kg/m2) with physical frailty will be randomized to 2 treatment groups: 1)10% weight loss, 2) 10% weight loss plus exercise training.

Official Title
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Effect of Weight Loss and Exercise on Intrahepatic and Intramyocellular Fat in Obese Older Adults

Conditions
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Obesity

Intervention / Treatment
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* Behavioral: weight loss and exercise
* Behavioral: weight loss


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Obese (BMI 30 or greater) Elderly (age 65 years or older) Exclusion Criteria: Major chronic disease or any condition that would interfere with exercise or dietary restriction, in which exercise or dietary restriction are contraindicated, or that would interfere with interpretation of results. Examples include cardiopulmonary disease, unstable disease, severe orthopedic or neuromuscular impairments, dementia, history of malignancy during the past 5 years

Ages Eligible for Study
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Minimum Age: 65 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>weight loss | Behavioral: weight loss<br>* 10 percent weight loss through diet and behavioral modification<br>* Other names: lifestyle change;|
| Experimental: 2<br>Weight loss and exercise | Behavioral: weight loss and exercise<br>* 10% weight loss through diet and exercise plus multicomponent exercise training three times a week<br>* Other names: lifestyle modification;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intrahepatic fat Intramyocellular fat |  | 6-month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Insulin sensitivity Physical Function |  | 6-month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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diet, weight loss, obesity, aging, exercise, physical function, Obesity in the Elderly