Neurological Sequelae in Patients With Acute Carbon Monoxide Poisoning

Study Overview
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Brief Summary
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The purpose of this study is to access the clinical characteristics and risk factors for neurological sequelae after acute carbon monoxide poisoning.

Detailed Description
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After being informed about the study and potential risks, patients meet the inclusion criteria would be given informed consent and entry the study. The data will be collected according to self-designed questionnaire, including :1) The baseline characteristics: would be recorded 6 hours after patients presentation;2) Patients' self evaluation for discomfort symptoms: would be recorded at day 0, week 1, 3 and 6, month 6 and 12；3) Neurological function: would be recorded at day 0, week 6, month 6 and 12.

Official Title
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The Characteristics of Neurological Sequelae in Patients With Acute Carbon Monoxide Poisoning

Conditions
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Carbon Monoxide Poisoning

Intervention / Treatment
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* Other: No intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients present within 12 hours after acute carbon monoxide poisoning; age older than 16 years. Exclusion Criteria: pregnant women； patients receive oxygen therapy before presentation; have history of acute carbon monoxide poisoning within 1 year; have been diagnosed any of the following disease: Parkinson disease; cognitive disorder, psychiatric disorders, sequelae of cerebral infarction or hemorrhage, chronic kidney disease and receive hemodialysis, congestive heart failure ( NYHA class III-IV)

Ages Eligible for Study
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Minimum Age: 16 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Non-NS ( Non-neurological sequelae) group<br>Patients who do not develop neurological dysfunction after acute carbon monoxide poisoning | Other: No intervention<br>* No intervention will be given<br>|
| NS (Neurological sequelae) group<br>Patients who develop neurological dysfunction after acute carbon monoxide poisoning | Other: No intervention<br>* No intervention will be given<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of Mini-mental State Examination (MMSE) score at 6 weeks | Score ranges from 0 to 30, a lower score means a worse outcome. | Changes of score from baseline to 6 weeks | 
| Changes of Mini-mental State Examination (MMSE) score at 6 months | Score ranges from 0 to 30, a lower score means a worse outcome. | Changes of score from baseline to 6 months | 
| Changes of Mini-mental State Examination (MMSE) score at 12 months | Score ranges from 0 to 30, a lower score means a worse outcome. | Changes of score from baseline to 12 months | 
| Changes of Montreal cognitive assessment (MoCA）score at 6 weeks | Score ranges from 0 to 30, a lower score means a worse outcome. | Changes of score from baseline to 6 weeks | 
| Changes of Montreal cognitive assessment (MoCA）score at 6 months | Score ranges from 0 to 30, a lower score means a worse outcome. | Changes of score from baseline to 6 months | 
| Changes of Montreal cognitive assessment (MoCA）score at 12 months | Score ranges from 0 to 30, a lower score means a worse outcome. | Changes of score from baseline to 12 months | 
| Changes of Hamilton Depression Scale(HAMD) score at 6 weeks | Score ranges from 0 to 54, a higher score means a worse outcome. | Changes of score from baseline to 6 weeks | 
| Changes of Hamilton Depression Scale(HAMD) score at 6 months | Score ranges from 0 to 54, a higher score means a worse outcome. | Changes of score from baseline to 6 months | 
| Changes of Hamilton Depression Scale(HAMD) score at 12 months | Score ranges from 0 to 54, a higher score means a worse outcome. | Changes of score from baseline to 12 months | 
| Changes of Hamilton Anxiety Scale (HAMA) score at 6 weeks | Score ranges from 0 to 56, a higher score means a worse outcome. | Changes of score from baseline to 6 weeks | 
| Changes of Hamilton Anxiety Scale (HAMA) score at 6 months | Score ranges from 0 to 56, a higher score means a worse outcome. | Changes of score from baseline to 6 months | 
| Changes of Hamilton Anxiety Scale (HAMA) score at 12 months | Score ranges from 0 to 56, a higher score means a worse outcome. | Changes of score from baseline to 12 months | 
| Changes of Activity of Daily Living (ADL) score at 6 weeks | Score ranges from 0 to 80, a higher score means a worse outcome. | Changes of score from baseline to 6 weeks | 
| Changes of Activity of Daily Living (ADL) score at 6 months | Score ranges from 0 to 80, a higher score means a worse outcome. | Changes of score from baseline to 6 months | 
| Changes of Activity of Daily Living (ADL) score at 12 months | Score ranges from 0 to 80, a higher score means a worse outcome. | Changes of score from baseline to 12 months | 
| Changes of self-evaluation of discomfort symptoms scale at 1 week | This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome | Changes of score from baseline to 1 week | 
| Changes of self-evaluation of discomfort symptoms scale at 3 weeks | This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome | Changes of score from baseline to 3 weeks | 
| Changes of self-evaluation of discomfort symptoms scale at 6 weeks | This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome | Changes of score from baseline to 6 weeks | 
| Changes of self-evaluation of discomfort symptoms scale at 6 months | This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome | Changes of score from baseline to 6 months | 
| Changes of self-evaluation of discomfort symptoms scale at 12 months | This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome | Changes of score from baseline to 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rates of cardiovascular and cerebrovascular events | Cardiovascular and cerebrovascular events includes：cardiac arrest, myocardial infarction, cerebral hemorrhage, and cerebral infarction. A patient develops any of the former diseases during following up would be record as 1 event. | through study completion, an average of 1 year | 
| Rates of accidental injury | Accidental injuries may include accidental fall, fracture, traffic accident etc. A patient develops any of the former during following up would be record as 1 event. | through study completion, an average of 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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carbon monoxide poisoning, neurological sequelae