Feasibility of Online MR-guided Radiotherapy on a 1.5T MR-Linac

Study Overview
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Brief Summary
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This study investigates the feasibility of imaging and treatment on a novel 1.5 T MR-Linac radiotherapy hybrid device.

Detailed Description
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Novel hybrid devices combine magnetic resonance imaging (MRI) and a linear accelerator in a single device. The superior soft tissue contrast compared with cone-beam computed tomography based treatment and the possibility for daily plan adaptation promise a higher precision of treatment, better target volume coverage and normal tissue sparing. In a first step the present study will test the feasibility of imaging and treatment on the 1.5 T MR-Linac.

Official Title
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Feasibility of Imaging and Radiotherapy on a Novel 1.5 T Hybrid Magnetic Resonance Imaging - Linear Accelerator System (MR-Linac)

Conditions
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Rectal Cancer, Head and Neck Cancer, Liver Cancer, Breast Cancer, Prostate Cancer, Oligometastasis, Esophageal Cancer

Intervention / Treatment
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* Radiation: Radiotherapy on the MR-Linac
* Diagnostic Test: Imaging on the MR Linac


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: existing indication for radiation therapy minimum age 18 years, no upper age limit capacity for consent Informed consent Exclusion Criteria: contraindication for MRI (claustrophobia, metallic implants not applicable for MRI pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Rectal and anal cancer<br>In this arm patients with rectal and anal cancer are recruited. | Radiation: Radiotherapy on the MR-Linac<br>* Radiotherapy is performed on the 1.5 T MR Linac<br>|
| Experimental: Prostate cancer<br>In this arm patients with prostate cancer are recruited. | Radiation: Radiotherapy on the MR-Linac<br>* Radiotherapy is performed on the 1.5 T MR Linac<br>|
| Experimental: Head and neck cancer<br>In this arm patients with head and neck cancers are recruited. | Radiation: Radiotherapy on the MR-Linac<br>* Radiotherapy is performed on the 1.5 T MR Linac<br>|
| Experimental: Esophageal cancer<br>In this arm patients with esophageal cancer are recruited. | Radiation: Radiotherapy on the MR-Linac<br>* Radiotherapy is performed on the 1.5 T MR Linac<br>|
| Experimental: Breast Cancer<br>In this arm patients with breast cancer are recruited. | Radiation: Radiotherapy on the MR-Linac<br>* Radiotherapy is performed on the 1.5 T MR Linac<br>|
| Experimental: Central nervous system tutors<br>In this arm patients with tumors of the central nervous system are recruited. | Radiation: Radiotherapy on the MR-Linac<br>* Radiotherapy is performed on the 1.5 T MR Linac<br>|
| Experimental: Palliative treatments<br>In this arm patients with palliative treatments are recruited. | Radiation: Radiotherapy on the MR-Linac<br>* Radiotherapy is performed on the 1.5 T MR Linac<br>|
| Experimental: Other<br>In this arm patients with other tumors are recruited. | Radiation: Radiotherapy on the MR-Linac<br>* Radiotherapy is performed on the 1.5 T MR Linac<br>|
| Experimental: Imaging only<br>In this arm patients receive only imaging on the MR-Linac | Diagnostic Test: Imaging on the MR Linac<br>* Only imaging performed on the MR Linac<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Feasibility of online MR guided Radiotherapy | Treatment of a patient is considered feasible when 85% of treatments were completed as planned in this patient | During every single patients treatment (i.e. between one to seven weeks after the first application of radiotherapy) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time analysis | Time required for online MR guided radiotherapy | During every single patients treatment (i.e. between one to seven weeks after the first application of radiotherapy) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Radiotherapy, Adaptive Radiotherapy