Outcomes of Neonatal Resuscitation

Study Overview
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Brief Summary
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The primary objective of this study is to describe mortality of newborns who received basic, advanced or no neonatal resuscitation immediately after birth at Shoklo Malaria Research Unit.

Detailed Description
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This is a retrospective, descriptive study of hospital records will be conducted. The existing dataset of newborns of ≥28 weeks gestation delivered at Shoklo Malaria Research Unit clinics from January 2008 to December 2015 will be analysed. In the dataset, 15224 newborns fulfill the inclusion criteria and therefore they will all be analysed with IBM SPSS Statistics 22 for Windows. Descriptive statistics will be used to define: a) the proportion of newborns alive at 24 hours, 7 days, 28 days, and at 1 year, following resuscitation at SMRU birthing rooms and b) the number of newborns requiring basic and advanced resuscitation. Measurements of correlation coefficient will be used to compare Shoklo Developmental test scores and developmental milestones attained at 1 year in resuscitated and non-resuscitated infants. The Pearson correlation coefficient will be used if the relationship between two variables is found to be linear. Antenatal, perinatal and postnatal characteristics associated with neonatal resuscitation will be defined by logistic regression analysis.

Official Title
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Outcomes of Neonatal Resuscitation in a Resource Limited Setting on the Thailand-Myanmar Border

Conditions
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Neonatal Resuscitation

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Liveborn singletons birthed at SMRU ≥28 weeks gestation Exclusion Criteria: Stillborn infants Liveborn infants birthed at home or in the Thai hospital Major congenital abnormalities

Ages Eligible for Study
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Maximum Age: 28 Weeks

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality 24 hours after birth of babies who received basic resuscitation |  | 24 hours | 
| Mortality 24 hours after birth of babies who received advanced resuscitation |  | 24 hours | 
| Mortality 24 hours after birth of babies who did not receive neonatal resuscitation |  | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality at 7 days |  | 7 days | 
| Mortality at 28 days |  | 28 days | 
| Mortality at one year |  | 1 year | 
| Proportion of live births requiring basic or advanced neonatal resuscitation. |  | 24 hours | 
| Number of newborns who received basic resuscitation, as a proportion of all live births. |  | 24 hours | 
| Number of newborns who received advance resuscitation, as a proportion of all live births. |  | 24 hours | 
| Shoklo Developmental test scores at 1 year in infants who received basic or advanced neonatal resuscitation or no resuscitation. |  | up to 1 year of age | 
| Month of achieved milestones (crawl, walk, talk) in in infants who received basic or advanced neonatal resuscitation or no resuscitation. |  | up to 1 year of age | 
| characteristics of antenatal infant receiving neonatal resuscitation compared to non-resuscitated infants as assessed by physiological parameter |  | 24 hours | 
| characteristics of perinatal infants receiving neonatal resuscitation compared to non-resuscitated infants as assessed by physiological parameter |  | 24 hours | 
| characteristics of neonatal infants receiving neonatal resuscitation compared to non-resuscitated infants as assessed by physiological parameter |  | 24 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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resource limited setting, Thailand-Myanmar border