Genotype and Phenotype in Early Onset Breast Cancer in Young Women on the Two Shores of the Mediterranean Sea

Study Overview
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Brief Summary
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Breast cancer are common on mediterranean basin. Epidemiological data suggest that breast cancer in young women (< 40years old) is more aggressive in the Maghreb countries comparatively to western countries. This aggressiveness could be associated with phenotypic and genotypic differences between this two populations.

Detailed Description
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The object of this study is to compare the genotypic and phenotypic differences between south and north shore of the mediterranean sea.

Conditions
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Breast Cancer

Intervention / Treatment
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* Genetic: Genetic analysis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient have or have had a breast cancer diagnosed before 40 years old Breast cancer proven by histology BRCA1/2 analysis proposed, realized, ongoing Women >18 years old Patient with insurance Patient informed and no-opposed Exclusion Criteria: Patient have or have had a breast cancer diagnosed after 40 years old Patient requiring tutorship or guardianship Adult patient protected by law

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| breast cancer in young women is in the Maghreb<br>breast cancer in young women (< 40years old) is in the Maghreb | Genetic: Genetic analysis<br> <br> |
| Breast cancer in young women in the western countries<br>Breast cancer in young women (< 40years old) in the western countries | Genetic: Genetic analysis<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Genetic analysis of Breast Cancer susceptibility gene 1 (BRCA 1) |  | The day of inclusion | 
| Genetic analysis of Breast Cancer susceptibility gene 2 (BRCA 2) |  | The day of inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analysis TNM grade | Tumors will be phenotyped by giving the histological characteristics (TNM and SBR grade, hormone receptors (ER, PR), growth factors (Ki 67) and HER2) | The day of inclusion | 
| Analysis histoprognostic grade Scarf Bloom and Richardson (SBR) | Tumors will be phenotyped by giving the histological characteristics (TNM and SBR grade, hormone receptors (ER, PR), growth factors (Ki 67) and HER2) | The day of inclusion | 
| analysis of hormone receptor ER | Tumors will be phenotyped by giving the histological characteristics (TNM and SBR grade, hormone receptors (ER, PR), growth factors (Ki 67) and HER2) | The day of inclusion | 
| growth factors analysis (Ki 67) | Tumors will be phenotyped by giving the histological characteristics (TNM and SBR grade, hormone receptors (ER, PR), growth factors (Ki 67) and HER2) | The day of inclusion | 
| analysis of HER2 | Tumors will be phenotyped by giving the histological characteristics (TNM and SBR grade, hormone receptors (ER, PR), growth factors (Ki 67) and HER2) | The day of inclusion | 
| analysis of hormone receptor PR | Tumors will be phenotyped by giving the histological characteristics (TNM and SBR grade, hormone receptors (ER, PR), growth factors (Ki 67) and HER2) | The day of inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Breast cancer