Protocol of Management of Major Pediatric Burn in Intensive Care Unit

Study Overview
=================
Brief Summary
-----------------
Decrease mortality and morbidity in major pediatric burns

Detailed Description
-----------------
The goals of initial patient management include preservation of overall homeostasis while appreciating the physiologic challenges that the burn injury poses to the body. Major burn injury not only results in local damage from the inciting injury, but in many cases results in multisystem injury. Initial efforts are focused on resuscitation, maintaining hemodynamic stability, and airway management. Intermediate efforts are focused on managing the multi-organ failure that results from systemic inflammatory mediators that result in diffuse capillary leak and surgical therapy. Finally, efforts shift to issues with chronic wound healing, pain management, restoration of functional capabilities, and rehabilitation.. Burn injury in children continues to be a major epidemiologic problem around the globe. Nearly a fourth of all burn injuries occur in children under the age of 16, of whom the majority are under the age of five This provides a team of pediatricians, surgeons, anesthesiologists, intensivists, nurses, respiratory therapists, and other healthcare providers with a unique opportunity to make a multidisciplinary collaborative effort.

Official Title
-----------------
Protocol of Management of Major Pediatric Burn in Intensive Care Unit

Conditions
-----------------
Burns

Intervention / Treatment
-----------------
* Other: protocol of management of major burn in intensive care unit


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age below 18 year children with burn between 20% to 50% of total body surface area recent burn within 48 hour Exclusion Criteria: old burn over 48 hour after injury -burnt surface area less than 20% of total body surface area - - burnt surface area more than 50% of total body surface area old age over 18 year

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: intensive care management<br>Administration of childern with major burn in intensive care to improve out comes | Other: protocol of management of major burn in intensive care unit<br>* primary assessment first aid management laboratory investigation radiological investigation surgical intervention<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changing mortality rate | Change mortality rate to lowest degree which due too severe burn less than 20% of childern with major burn | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changing hospital stay time | Hospital stay less than 30 days | Baseline |