Structural Cartography of the Insula in Temporal Epilepsy Patients

Study Overview
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Brief Summary
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The purpose of this study is to investigate insula structural connectivity in temporal epilepsy patients. Insula being at the interface of frontal, parietal, occipital and temporal lobes, its structural organization reflects the brain function. We hypothetize that insular structural organization will be different according to the different subtypes of temporal epilepsy.

Detailed Description
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The purpose of this study is to investigate insula structural connectivity in temporal epilepsy patients. Insula being at the interface of frontal, parietal, occipital and temporal lobes, its structural organization reflects the brain function. We hypothetize that insular structural organization will be different according to the different subtypes of temporal epilepsy.

Official Title
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Structural Cartography of the Insula in Temporal Epilepsy Patients

Conditions
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Epilepsy, Temporal Lobe, MRI Scans

Intervention / Treatment
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* Other: MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: epileptic patients: temporal epilepsy or temporal plus epilepsy (temporomesial epilepsy, basal temporal epilepsy, mesio lateral or lateral epilepsy, temporo insular epilepsy, operculo insular epilepsy) patients who underwent video EEG monitoring with recorded seizures (at least one) patients who underwent a brain MRI with DTI sequence before epilepsy surgery patients who did not refuse the use of their clinical and MRI data for this study Exclusion Criteria: patients younger than 15 years old patients with previous brain surgery (before MRI) uncompleted MRI sequences (DTI, T1 anatomical)

Ages Eligible for Study
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Minimum Age: 15 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| mesio-temporal epilepsy<br>patients suffering from mesiotemporal epilepsy type | Other: MRI<br>* structural imaging<br>|
| basal temporal epilepsy<br>patients suffering from basal temporal epilepsy type | Other: MRI<br>* structural imaging<br>|
| temporal lateral epilepsy<br>patients suffering from temporal lateral epilepsy type | Other: MRI<br>* structural imaging<br>|
| operculo insular epilepsy<br>patients suffering from operculo insular epilepsy type | Other: MRI<br>* structural imaging<br>|
| temporo-insular epilepsy<br>patients suffering from temporo- insular epilepsy type | Other: MRI<br>* structural imaging<br>|
| healthy subjects<br>non epileptic patients | Other: MRI<br>* structural imaging<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cartography of insula in temporal epilepsy patients | Compared with healthy group, definition of different patterns of insular structural connectivity in epileptic patients | 1 year after the last inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation structural cartography and electroclinical data | correlation between patterns of insular structural connectivity and subtypes of epilepsy defined by electroclinical data | 1 year after the last inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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structural connectivity, insula, temporal lobe epilepsy