Coronavirus Infection in Primary or Secondary Immunosuppressed Children and Adults.

Study Overview
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Brief Summary
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A weekly questionnaire is sent to patients and parents of patients who are vulnerable for infections. Possible symptoms of COVID19 are asked for and use of healthcare services and testing for COVID19. Weekly reports are being send to the national institutions to update advice given to this group.

Detailed Description
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This study is designed to allow immunosuppressed children, their parents or adult patients to self-record their experiences of COVID-19 and other viral respiratory illnesses. Patients, parents and of immunosuppressed patients and patients aged 16-17 yrs will be provided with online information and asked to fill in online questionnaires at baseline and weekly thereafter. Information collected includes medication, symptoms, contact with health care providers, test results and impact on daily activities. Data will be collected and analysed weekly to be able to monitor any potential risk factors for severe disease. This study is complementary to, and not overlapping with, the global ISARIC World Health Organisation protocol that will be studying COVID-19 cases admitted to all National Health Service (NHS) Trusts, including all children.

Official Title
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Coronavirus Infection in Primary or Secondary Immunosuppressed Children and Adults.

Conditions
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Immune Suppression, Immune Deficiency, Infection, COVID, Children, Adult

Intervention / Treatment
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* Other: Questionnaire


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Children part: Parent of immunosuppressed patient aged <16 years or immunosuppressed patient aged 16-17 years Adult part: Immunosuppressed patient aged >17 years Family or themselves able to complete the questionnaire which will be in English (due to current resources available translation will not be possible) Reliable access to the internet Exclusion Criteria: Unable to understand English

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Questionnaire|A weekly questionnaire will be filled in|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To describe COVID19 infection in children/adults who are vulnerable for infection in an outpatients setting | To describe frequency of cough, fever, diarrhoea, shortness of breath, sore throat, blocked nose, red eyes, headache, joint pain, muscle pain, fatigue, chills, nausea, vomiting, diarrhoea over a year | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of children/adults tested positive for COVID19 | Patient/parent reported positive tests for COVID19 | 1 year | 
| Number of children/adults admitted in hospital because of COVID19 | Patient/parent reported admissions in hospital because of COVID19 | 1 year | 
| To assess the impact of COVID19 infection on the daily activities of immunosuppressed adults and children | Patient/parent reported effect of COVID19 on daily activities | 1 year |