Comparison of the Impacts of Sugammadex With Neostigmine on Patency of Laryngeal Opening (Glottic Aperture Angle)

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to compare the degree of change in the angle of the vocal cords before and after administration of neostigmine or sugammadex. Moreover, we intend to compare the angle of vocal folds after administration of neostigmine or sugammadex.

Official Title
-----------------
Comparison of the Impacts of Sugammadex With Neostigmine on Patency of Laryngeal Opening (Glottic Aperture Angle)

Conditions
-----------------
Supraglottic Airway Device Insertion

Intervention / Treatment
-----------------
* Drug: Sugammadex
* Drug: Neostigmine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1. Adult patients who undergoes elective surgery under general anesthesia with supraglottic airway device. Exclusion Criteria: Patients under 20 years old Pregnant women Patients who can not read the consent form or are not fluent in Korean (illiterate, foreigner) Patients who refused the clinical trial Patients with dementia or cognitive impairment Patients with neuromuscular disorders impairing neuromuscular blockade Renal dysfunction (estimated Glomerular Filtration Rate less than 30 ml/min/1.73m2) Past history of allergic reactions to neostigmine or sugammadex Patients with ASA class IV or higher Robotic surgery, adenoid or tonsillectomy Patients with moderate or severe asthma, pulmonary function tests with forced expiratory volume for 1second of 1 liter or less, patients with upper respiratory infection symptoms within 2 weeks before surgery, current smokers (within 1 month of smoking cessation is included.)

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Sugammadex<br>Administration of Sugammadex | Drug: Sugammadex<br>* Administration of Sugammadex for muscle relaxation reversal<br>|
| Active Comparator: Neostigmine<br>Administration of Neostigmine | Drug: Neostigmine<br>* Administration of Neostigmine for muscle relaxation reversal<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Angle of vocal folds after administration of sugammadex or neostigmine 2) Degree of change in angle of vocal folds before and after administration of sugammadex or neostigmine |  | 1-2 minutes after drug administration (inhalation, exhalation) | 
| Degree of change in angle of vocal folds before and after administration of sugammadex or neostigmine |  | 1) Just before drug administration 2) 1-2 minutes after drug administration (inhalation, exhalation) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to recover from spontaneous breathing | Time taken to recover from spontaneous breathing(6ml/kg or more) after administration of sugammadex or neostigmine | immediately after drug(sugammadex or neostigmine) administration | 
| Time to extubation | Time taken to extubation after administration of sugammadex or neostigmine | immediately after drug(sugammadex or neostigmine) administration |