Effect of Childhood Radioiodine Therapy on Salivary Function

Study Overview
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Brief Summary
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Radioiodine (I-131) therapy for thyroid disease is known to decrease salivary function in adult patients. The impact of pediatric I-131 exposure on salivary function is unknown. The investigators goals are to answer this question by measuring salivary gland function before and after I-131 administration in children who receive radioiodine therapy at our hospital for thyroid disease.

Detailed Description
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Radioiodine (I-131) therapy for thyroid disease is known to decrease salivary function in adult patients. The impact of pediatric I-131 exposure on salivary function is unknown. The investigators goals are to answer this question by measuring salivary gland function before and after I-131 administration in children who receive radioiodine therapy at our hospital for thyroid disease. We will use a Modified Shirmer Test to measure saliva production and a questionnaire to evaluation symptoms of xerostomia.

Official Title
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Effect of Childhood Radioiodine Therapy on Salivary Function

Conditions
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Xerostomia, Hyperthyroidism, Thyroid Cancer

Intervention / Treatment
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* Other: Radioiodine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who have been treated with radioiodine therapy Patients who have never received radioiodine therapy (negative control group) Exclusion Criteria: Non-English speaking subjects will be excluded due to our lack of translation support resources at this time. Of note, participation in our study cannot benefit participants in any way.

Ages Eligible for Study
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Minimum Age: 3 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Radioiodine<br>Patients with a history of childhood treatment with radioiodine will be assessed for symptoms of salivary function and measurement of saliva production. These data will be compared to a normal control group. | Other: Radioiodine<br>* We will determine if prior radioiodine treatment in childhood impacts salivary function or symptoms. Radioiodine treatment will have been determined by the patient's medical condition and care (NOT assigned by this research study).<br>|
| Control<br>Patients who are similar in age to those in the Radioiodine group, but who did not recieve I-131 therapy. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Salivary function (MST value) | sterile paper strip is used to measure saliva production (noninvasive testing) | 0 to 50 years after radioiodine treatment | 
| Responses to Dry Mouth Questionnaire | Patient questionnaire/survey | At time of visit up to 4 months thereafter. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Caries history (number of caries noted in dental records) |  | 1 year before radioiodine administration to 4 months after study visit. |