Development of MRI Protocols and Associated Neuro-physiological Explorations in Healthy and Pathological Subjects

Study Overview
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Brief Summary
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IRMaGe is a Joint Service Unit (UMS) which provides users of brain exploration equipment (clinical MRI and preclinical, TMS, EEG, NIRS and metabolomics). The methods available on this equipment are intended to evolve according to the most recent discoveries and this protocol aims to frame the developments necessary around clinical MRI for IRMaGe can continue to offer tools at the cutting edge of technology.

Detailed Description
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The studies will be carried out on healthy subjects and voluntary patients, who will have given their consent. Their main objective will be the development and optimization of sequence parameters or design stimulation paradigms in order to optimize the quality and relevance of the images produced taking into account the parameters anatomical, functional or metabolic while respecting the experimental constraints imposed by the protocol concerned (equipment of experimentation, additional physiological measurements, etc.). The main judgement criteria will be measurements inherent in the MRI sequence and a physiological measurement associated in the protocol concerned

Official Title
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Development of MRI Protocols and Associated Neuro-physiological Explorations in Healthy and Pathological Subjects

Conditions
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MRI, Sequence Optimization, Physiological Measurement

Intervention / Treatment
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* Device: MRI Protocol


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participants with normal or corrected vision Participants affiliated to a social security scheme or beneficiaries of such a scheme Participants with French as their mother tongue Participants who have given the signed informed consent before carrying out any procedure related to the study. Volunteer patients will be recruited as part of their follow-up at the CHU. Their pathology will be in agreement with that of the research protocol to be optimized. Exclusion Criteria: Criteria relating to contraindications to the explorations provided for by the MRI protocol: metallic glitter in the eyes retinal operation claustrophobia wearer of pacemaker or cardiac defribrillator or vascular clip or prosthesis cardiac or insulin pump or implanted device to deliver medication or hearing implant or prosthesis or vascular shunt or paragraph or screws, plate metal or tattoo or piercing or implanted metal object or lead shot hunt Alcohol ingestion before the examination Pregnant, lactating and parturient women Major protected by law Participants under administrative or judicial supervision Participation in another ongoing study if the study may interfere with participation in the protocol MAP-IRMaGe.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Interventional Model Description: Exploratory individual statistical analyzes on MRI data functional. No group analysis possible on these updates of MRI protocols
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: MRI protocol<br>Feasibility and use of methods developed in clinical research protocols or cognitive: the reproducibility of the parameters of acquisition, of the design of the activation paradigms development and results according to people will be an important element for the future integration of these methods in clinical or cognitive research protocols. | Device: MRI Protocol<br>* Eye-tracker Eyelink (eye movements) BIOPAC : (electrodermal resistance) INVIVO Precess : breathing, arterial pressure, pulse, NIRS Oxymon artinis medical system tES (transcranial electrical stimulation, Neuroelectrics)<br>* Other names: Physiological measurement during MRI protocol;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diffusion Tensor Imaging Images | DTi sequences on IRM Achieva 3.0T dStream Philips | 1 to 3 hours | 
| BOLD Signal | EPI sequences during cognitive protocol on IRM Achieva 3.0T dStream Philips | 1 to 3 Hours | 
| Anatomical Images | Anatomical MR sequences on IRM Achieva 3.0T dStream Philips | 1 to 3 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Eye movements | Acquired by using eye-tracker (Eye-tracker Eyelink) breathing arteries pressure electrodermal conductance | During MRI session | 
| Electrodermal resistance | Acquired on BIOPAC device allowing physiological measurements | During MRI session | 
| Blood Pressure/pulse/Breathing | Acquired on INVIVO Precess | During MRI session | 
| Near-infrared spectroscopy (NIRS) : Hb OHb concentration measurement | Acquired with NIRS Oxymon artinis medical system | During MRI session | 
| tES | Transcranial Electrical stimulation, Neuroelectrics | During MRI session |