Evaluate the Effectiveness of Brain Network Activation (BNA™) Technology in the Management of Sport Related Concussion

Study Overview
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Brief Summary
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Currently, there is no direct, reliable, bed-side, and non-invasive method for assessing changes in brain activity associated with concussion. Event Related Potentials (ERPs), which are temporal reflections of the neural mass electrical activity of cells in specific regions of the brain that occur in response to stimuli, may offer such a method, as they provide both a noninvasive and portable measure of brain function. The ERPs provide excellent temporal information, but spatial resolution for ERPs has traditionally been limited. However, by using high-density electroencephalograph (EEG) recording spatial resolution for ERPs is improved significantly. The paradigm for the current study will combine neurophysiological knowledge with mathematical signal processing and pattern recognition methods (BNA™) to temporally and spatially map brain function, connectivity and synchronization. The proposed study will provide additional evidence for the utility and contribution of the BNA™ test (reflecting temporal and spatial changes in brain activity as well as brain functional connectivity associated with concussion) in concussion management.

Official Title
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Evaluate the Effectiveness of Brain Network Activation (BNA™) Technology in the Management of Sport Related Concussion in the College Age Athletes

Conditions
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Minor Traumatic Brain Injury (TBI)

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 17-24, both genders, enrolled in a recognized college and members of a sport team of their school. Exclusion Criteria: Current or history of any of the following: TBI (i.e., Glasgow Coma Scale <13) or brain surgery Any psychiatric disorder Any Neurological disorder Substance abuse Special education Any medication affecting CNS Significant sensory deficits such as deafness or blindness Residual symptoms or deficits related to a previous concussion

Ages Eligible for Study
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Minimum Age: 17 Years
Maximum Age: 24 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| college athletes<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in BNA™ measures during the sport season in both concussed and non concussed athletes compared to pre season BNA™ baseline measures. |  | an average of 1 year | 
| Correlation of the BNA measures in both concussed and non concussed athletes to the clinical diagnosis. |  | an average of 1 year | 
| To assess the clinical utility of changes in BNA in assisting with clinical decision-making. |  | an average of 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Minor traumatic brain injury (TBI), Concussion