Serologic Testing of Household Contacts of Confirmed Cases of COVID-19

Study Overview
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Brief Summary
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SARS-CoV-2 has now crossed the 1 million number of cases and tens of thousands of deaths. It´s R0 has been calculated between 2 and 5.7 solely based on clinical symptoms but it is estimated to likely be higher. Serologic evidence of infection has not been analyzed.

Detailed Description
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Transverse, observational and descriptive study involving household contacts of documented patients with COVID-19 infection: contacts will be invited to participate and a blood sample will be drowned: IgM and IgG qualitative and quantitative measurements will be performed. Demographic data regarding age, comorbidities, calculated time spent before and after the patients diagnosis, isolation practices etc.

Official Title
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Observational Trial Evaluating the Serologic Status of Household Contacts of Patients Diagnosed With COVID-19

Conditions
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Coronavirus Infection

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Persons over 1 years of age. .Meet COVID-19 confirmed case intradomestic contact definition: Living in the same home as the patient with SARS-CoV-2 PCR test detected (nasopharyngeal and/or oropharyngeal swab) performed in the Acute Respiratory Infection Diagnostic Unit. Living in the same home as the patient with a PCR test for SARS-CoV-2 Indeterminate (nasopharyngeal and/or oropharyngeal swab) performed in the Acute Respiratory Infection Diagnostic Unit and that the initial patient has positive IgM/IgG serology for SARS-CoV-2. .Informed Consent. Exclusion Criteria: .Have fever, cough, pharyngeal pain or clinically have symptoms compatible with COVID-19 at the time of recruitment. .Autoimmune disease, cancer, neutropenia. .Under 1 years of age. .Patients who, in the investigator's opinion, should be excluded from the research protocol.

Ages Eligible for Study
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Minimum Age: 1 Year

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Identify antibodies | Identify the presence of IgM and IgG antibodies from intradomestic contacts of patients with Polymerase Chain Reaction for detected SARS-CoV-2 . | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determine antibody sensitivity | Determine the sensitivity of IgM and IgG antibody detection by ELISA in direct eastern contacts of patients with PCR for detected SARS-CoV-2. | 1 day | 
| IgM determination | Determine the presence of IgM antibodies by ELISA in direct eastern contacts of patients with detected SARS-CoV-2 PCR. | 1 day | 
| IgG determination | Determine the presence of IgG antibodies by ELISA in direct eastern contacts of patients with detected SARS-CoV-2 PCR. | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COVID-19, IgM/IgG antibodies, Intradomestic contacts, IgM/IgG serological tests