linjc16/ctgov huggingface dataset:
Incidence of Acute Pulmonary Embolism in Covid-19 Patients on CT Angiography and Relationship to D-dimer Levels

Study Overview
=================
Brief Summary
-----------------
Reports of acute pulmonary embolism (APE) associated with COVID-19 have emerged in the literature. For example, Chen et al. described 25 pulmonary CT angiograms examinations from 1008 COVID-19 patients; 10 were positive for pulmonary embolism mostly as segmental or sub-segmental APE. Case reports of APE in Covid-19 patients have been published. Cui et al. found an incidence of deep venous thrombosis in intensive care unit (ICU) patients with severe Covid-19 pneumonia near to 25% (20/81), however without any correlation with potential APE. Despite these initial reports, it is not clear whether APE is more frequent in Covid-19 patients or if the association is just random. In favor of the former, D-dimer levels have been reported as elevated in patients with Covid-19 by two studies, and it has been suggested an independent association between the severity of the disease and the level of D-dimer. Finally, Tang et al. showed that anticoagulant therapy is associated with a decreased mortality at Day-28 in severe Covid-19 patients, in favor of a possible associated coagulopathy. The purpose of this study is to describe the rate of pulmonary embolus in patients classified as COVID-19 infection and who underwent chest CT angiography. The purpose of this study is to describe the rate of pulmonary embolus in patients classified as COVID-19 infection and who underwent chest CT angiography.

Official Title
-----------------
Incidence of Acute Pulmonary Embolism in Covid-19 Patients on CT Angiography and Relationship to D-dimer Levels

Conditions
-----------------
Covid-19 With Positive RT-PCR

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Positive SARS-Cov-2 RT-PCR Chest CT angiography available Patient is aged 18yo or above Exclusion Criteria: Expressed opposition to participate Adults under guardianship

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of positivity for Acute Pulmonary Embolism |  | March 1, 2020 - March 31, 2020 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Covid-19, Pulmonary Embolism, CT angiography
Fertilizations With Immotile Sperm: Pentoxyphylline Activation Alone, or With Chemical Oocyte Activation

Study Overview
=================
Brief Summary
-----------------
Immotile sperm is a rather frequent problem encountered in IVF patients. Treatment is usually based on inducing motility with pentoxyphylline (PXN) followed by ICSI. However, fertilization rate with this method is still lower compared with ICSI using motile sperm. One of the reasons for that is the immotile sperm inability to activate the oocyte Our research hypothesis is that better fertilization rate can be accomplished in these cases by combining PXN sperm activation with Ca ionophore oocyte activation.

Official Title
-----------------
A Randomized Controlled Trial to Compare Fertilizations With Immotile Sperm After Pentoxyphylline Activation Alone, or With Chemical Oocyte Activation

Conditions
-----------------
Infertility

Intervention / Treatment
-----------------
* Biological: PXN sperm treatment
* Biological: Sperm activation with PXN and oocyte activation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Women up to 35 years of age immotile sperm At least 6 mature eggs Exclusion Criteria: globozoospermia Freeze all cycles because of OHSS risk.

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: PXN only<br>Sperm activation with PXN before ICSI | Biological: PXN sperm treatment<br>* immotile sperm activation with PXN<br>|
| Experimental: PXN activation and oocyte activation<br>Sperm activation with PXN and oocyte activation | Biological: Sperm activation with PXN and oocyte activation<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical pregnancy | Demonstration of fetal heart activity 1 month post oocyte retrieval. | One month post oocyte retrieval | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fertilization rate | Normal, 2 pronuclei, zygote one day post ICSI | One day post oocyte retrieval | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
ICSI, Asthenospermia, pentoxyphylline, Spermatozoa, IVF
Optimal Lidocaine Buffering to Reduce Injection Pain in Local Anesthesia

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine the optimal amount of lidocaine buffering needed to decrease injection pain when administering local anesthesia.

Detailed Description
-----------------
Once the site is chosen, the skin will be anesthetized as usual. This study will utilize a commercially prepared 1% lidocaine solution mixed with standard sodium bicarbonate. A total of 10 mL will be used.

Official Title
-----------------
Optimal Lidocaine Buffering to Reduce Injection Pain in Local Anesthesia

Conditions
-----------------
Local Anesthesia

Intervention / Treatment
-----------------
* Drug: lidocaine
* Drug: sodium bicarbonate


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: adults presenting for routine thyroid biopsy, paracentesis or thoracentesis in interventional radiology Exclusion Criteria: Patients requiring sedation Patients with altered mental status Children Patients allergic to lidocaine or sodium bicarbonate

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Arm A<br>10 mg/mL lidocaine; Frequency: 1 | Drug: lidocaine<br>* local anesthesia<br>* Other names: xylocaine;|
| Active Comparator: Arm B<br>9 mg/mL of 10% sodium bicarbonate-90% lidocaine; Frequency: 1 | Drug: lidocaine<br>* local anesthesia<br>* Other names: xylocaine;Drug: sodium bicarbonate<br>* additional drug added to lidocaine<br>|
| Active Comparator: Arm C<br>7.5 mg/Ml of 25% sodium bicarbonate-75% lidocaine Frequency: 1 | Drug: lidocaine<br>* local anesthesia<br>* Other names: xylocaine;Drug: sodium bicarbonate<br>* additional drug added to lidocaine<br>|
| Active Comparator: Arm D<br>5 mg/mL 50% sodium bicarbonate-50% lidocaine Frequency: 1 | Drug: lidocaine<br>* local anesthesia<br>* Other names: xylocaine;Drug: sodium bicarbonate<br>* additional drug added to lidocaine<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Injection pain | numeric pain scale | 6 months |
Surgery Versus Manual Rupture for Dorsal Carpal Ganglion

Study Overview
=================
Brief Summary
-----------------
This study objectives are to compare the efficacy and safety between surgical excision and manual rupture for dorsal carpal ganglion.The participants with dorsal carpal ganglion will be randomized into 2 groups:surgical excision or manual rupture.The patients will be follow-up for at least 1 yr.Telephone interview will be used for outcome assessment.

Official Title
-----------------
Comparison Between Surgical Excision and Manual Rupture for Dorsal Carpal Ganglion

Conditions
-----------------
Dorsal Carpal Ganglion

Intervention / Treatment
-----------------
* Procedure: local excision


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with dorsal carpal ganglion Exclusion Criteria: underlying rheumatic condition bleeding tendency

Ages Eligible for Study
-----------------
Minimum Age: 15 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: local excision|surgical excision by orthopaedic surgeon under local anesthesia|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| recurrence rate |  | 1,2 and 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| time to recurrence |  | 1,2 and 3 years | 
| DASH score |  | 1,2 and 3 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
surgery, manual rupture, dorsal carpal ganglion
Aspiration of Limited Number of Follicles to Prevent Severe Ovarian Hyperstimulation Syndrome

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the effect of single ovarian puncture to retrieve 7eggs only in prevention of severe ovarian hyperstimulation syndrome.

Detailed Description
-----------------
Thirty patients will be selected for this study grouped into two groups, each group contains fifteen patients. Group 1 :study group ( retrieval of 7 eggs only). Group 2 :control group ( retrieval of all eggs). Study is held to compare between the two arms, the proportion of patients who will be prevented from the progression to severe OHSS after this interventional method.

Official Title
-----------------
Aspiration of Limited Number of Eggs to Prevent Severe OHSS in Suspected Cases

Conditions
-----------------
Infertility

Intervention / Treatment
-----------------
* Procedure: 7 eggs collection
* Procedure: Full eggs collection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: More than 9 days of induction of ovulation. Each ovary contains more than 20 follicles. The majority of follicles are >14mm in diameter. Mild fluid in Douglas pouch. The patient started to complain of considerable lower abdominal pains before the egg collection. Exclusion Criteria: Recurrent ICSI failure or bad obstetric history. Any medical disorder affecting the fluid shift as: diabetes mellitus, autoimmune diseases, hepatic, renal or cardiac conditions.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 7 eggs collection<br>Aspiration of 7 eggs only | Procedure: 7 eggs collection<br>* vaginal US<br>|
| Active Comparator: Full eggs collection<br>Aspiration of all eggs | Procedure: Full eggs collection<br>* vaginal US<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants of Severe Ovarian Hyperstimulation Syndrome |  | 2 weeks |
Barrier Function Measurement in Dry Eye Patients After Using Systane Ultra for 30 Days

Study Overview
=================
Brief Summary
-----------------
The primary objective is to determine if there is a correlation between reductions in corneal staining and improvements in corneal barrier function.

Official Title
-----------------
Barrier Function Measurement in Dry Eye Patients After Using Systane Ultra for 30 Days

Conditions
-----------------
Dry Eye

Intervention / Treatment
-----------------
* Other: Systane® Ultra


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients must have moderate corneal staining and exhibit a need to use artificial tears. Exclusion Criteria: Patients can not participate in any other ophthalmic drug or device clinical trial within 30 days of the baseline visit.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Systane® Ultra<br> | Other: Systane® Ultra<br>* Systane® Ultra 1-2 drops, 4 times per day for 30 days<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percent change from baseline of corneal fluorescein |  | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adverse event occurence |  | 30 Days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Dry Eye Signs, barrier function
Impact of Renal Replacement Therapy on Coagulation Profile of Patients With Acute Renal Failure

Study Overview
=================
Brief Summary
-----------------
Renal failure and high plasmatic level of urea have been associated with an increased risk of hemorrhage in surgical patients. There is only sparse data on the impact of renal replacement therapy on homeostatic parameters. The aim of this study is to describe potential changes in homeostatic parameters before and after renal replacement therapy.

Official Title
-----------------
Impact of Renal Replacement Therapy on Coagulation Profile in Patients With Acute Renal Failure

Conditions
-----------------
Acute Renal Failure, Hemorrhage, Coagulation Disorder

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: critically ill patients acute renal failure renal replacement therapy plasmatic urea > 20 Exclusion Criteria: chronic renal failure platelet count less than 80 Giga V factor less than 70%

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| visco elastometry | ROTEM (Rotational Thromboelastometry) | Change in ROTEM parameters from baseline to after renal replacement therapy | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
renal replacement therapy, acute renal failure, coagulation, bleeding
Evaluation of Computerized Template Entry for Compensation and Pension (C&P) Examinations

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to compare C&P examination reports performed using a Compensation and Pension Examination Program (CPEP) computerized, templated documentation tool to a customary examination performed and then report dictated in quality, completeness, timeliness and veteran satisfaction.

Official Title
-----------------
Evaluation of Computerized Template Entry for C&P Examinations

Conditions
-----------------
Joint Diseases

Intervention / Treatment
-----------------
* Other: Computer based template for exam documentation
* Other: Dictation for exam documentation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subjects for the current study included veterans scheduled for C&P examination of two or fewer joints at VA TVHS. No ethnic or racial group or gender was excluded. Exclusion Criteria: Veterans were excluded if they were scheduled: for examination of more than two joints, with other requested exam protocols in addition to joints
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: 1<br>exam documentation performed using dictation | Other: Dictation for exam documentation<br>* exam documentation performed using dictation, the standard practice<br>|
| Experimental: 2<br>exam documentation performed using computer based template | Other: Computer based template for exam documentation<br>* exam documentation performed using computer based template<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| disability exam report quality |  | upon completion of report, generally within 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| disability exam report data entry time |  | upon creation of report | 
| disability exam encounter time |  | upon creation of report | 
| disability exam patient satisfaction |  | following exam | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Disability Evaluation, Joint Diseases, Joint Disability
Reasons for Nonattendance Inpatient Colonoscopy

Study Overview
=================
Brief Summary
-----------------
The absence of colonoscopy is a clinical problem that can't be ignored. According to previous studies, the absence rate for outpatient colonoscopy is between 4% and 29%. The aim of this study is to determine the reasons for colonoscopy appointment cancellations among inpatients and to identify the factors associated with colonoscopy nonattendance.

Official Title
-----------------
Reasons for Nonattendance Inpatient Colonoscopy: a Cross-sectional Study

Conditions
-----------------
Colonoscopy Nonattendance, Inpatient

Intervention / Treatment
-----------------
* Other: no intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: inpatients older than 18 years. inpatients undergoing colonoscopy Exclusion Criteria: Emergency colonoscopy. Pregnant or breastfeeding. Lack of complete data.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| group A<br> | Other: no intervention<br>* no intervention<br>|
| group I<br> | Other: no intervention<br>* no intervention<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| nonattendance rate of colonoscopy appointment | The nonattendance rate is calculated as dividing the number of inpatients but whom colonoscopies canceled to the total number of patients multiply by 100. | 1 Day of colonoscopy | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| reason for colonoscopy cancellation | The root causes for colonoscopy appointment cancellation,such as patient-related reason, medical-related reason,administration-related reason,etc. | 1 Day of colonoscopy |
Impact of Gluten Contamination in Celiac Patients Clinically Responsive and Unresponsive to the Gluten-free Diet

Study Overview
=================
Brief Summary
-----------------
The primary aim of the study is to detect the presence of gluten immunogenic peptides (GIP) in urine samples from celiac patients on a gluten-free diet clinically responsive and non-responsive to dietary treatment and from suspected celiac patients already on a gluten-free diet.

Detailed Description
-----------------
Once a year, celiac patients perform a clinical (gastroenterological visit) and blood chemistry (blood tests) check. At the Center for the Prevention and Diagnosis of Celiac Disease, about 1400 check-ups of celiac patients are carried out per year. During this annual control visit, consecutive patients afferent to the center and suffering from celiac disease who have been treated for more than 6 months, clinically responsive and non-responsive to the gluten free diet (GFD), will be invited to participate in the proposed study. Those who participate will be given the symptom questionnaires (VAS), the food questionnaire in order to evaluate the relevance of the symptoms reported and the type of diet followed by the patient and the adherence test to the gluten-free diet (CDAT). Urine samples will be collected to test the presence of GIP (gluten immunogenic peptides) and for patients whose samples test positive, will be asked for a stool sample to detect GIP. Subjects with suspected celiac disease but already on a gluten-free diet will undergo a challenge, or the reintroduction of gluten in incremental steps of three weeks (routinely performed as per the instructions of the Italian Health Care System).

Official Title
-----------------
Impact of Gluten Contamination in Celiac Patients Clinically

Conditions
-----------------
Celiac Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age: 18 to 65 years old Gender: Males and Females Patients: suffering from Celiac Disease and suspected, but already on a gluten-free diet Exclusion Criteria: Celiac patients less than 6 months after diagnosis Celiac patients reporting intentional gluten ingestion

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| GIP | GIP Immunogenic Peptide Assay in Urine | 3 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gluten-free diet | Assessment of adherence to gluten-free diet and of gluten food intake | 3 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
GIP, non celiac gluten sensitivity, gluten reintroduction