Intra-articular Corticosteroid Injection Compared With Single-Shot Hyaluronic Acid for Treatment of Osteoarthritis Knee

Study Overview
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Brief Summary
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Corticosteroid and Hylan G-F 20 are both effective in improving pain and function of osteoarthritic knee patients.

Detailed Description
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Corticosteroid and Hylan G-F 20 are both effective in improving pain and function of osteoarthritic knee patients up to 6 months.

Official Title
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Intra-articular Corticosteroid Injection Compared With Single-Shot Hyaluronic Acid for Treatment of Osteoarthritis Knee: A Prospective, Double-blind Randomized Controlled Trial

Conditions
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Knee Osteoarthritis

Intervention / Treatment
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* Drug: Hylan G-F 20
* Drug: Corticosteroid


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical diagnosis of knee OA Knee pain for most days of the prior month Radiographic evidence consistent with knee OA Aged between 40 and 80 years old Exclusion Criteria: Lumbar spondylosis Gross deformity of the knee Co-existent inflammatory or crystal arthritis Prior knee surgery Injury to the knee in the preceding 6 months Any intra-articular injection in the preceding 3 months Pregnant or Lactating Current infection in the affected knee Inability to provide informed consent

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Single shot Hylan G-F 20 (Synvisc)<br>Intra-articular injection of the Single shot 6 mL of Hylan G-F 20 (Synvisc) | Drug: Hylan G-F 20<br>* After full aseptic preparation, Single shot intra-articular injection either 6 mL of Hylan G-F 20 or 1 mL of 40 mg triamcinolone acetonide plus 5 mL of 1% xylocaine with adrenaline were injected into the joint cavity using the infero-lateral approach via a 21-gauge needle.<br>* Other names: Synvisc;|
| Active Comparator: Corticosteroid (Triamcinolone acetonide)<br>Intra-articular injection of 1 mL of 40 mg Triamcinolone acetonide plus 5 mL of 1% xylocaine with adrenaline injected at the knee by single shot | Drug: Corticosteroid<br>* After full aseptic preparation, Single shot intra-articular injection either 6 mL of Hylan G-F 20 or 1 mL of 40 mg triamcinolone acetonide plus 5 mL of 1% xylocaine with adrenaline were injected into the joint cavity using the infero-lateral approach via a 21-gauge needle.<br>* Other names: Triamcinolone acetonide;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| WOMAC Score | Change from Baseline in WOMAC score at 6 months | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual Analogue Scale(VAS) | Change from Baseline in VAS score at 6 months | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Knee Osteoarthritis, Corticosteroid, Hyaluronic acid, Intra-articular injection