Redox State in the Course of Chronic Renal Insufficiency and Hemodialysis: Implications in Morbimortality

Study Overview
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Brief Summary
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The influence of hemodialysis on oxidative stress, endothelial activation, inflammation and on the redox state of lymphocytes should be clarified as well as the putative relationships between all these parameters.

Detailed Description
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Up to now, no anti-oxydative treatment has been able to reduce the mortality of the patients with Kidney Failure. Thus it is necessary to have a better knowledge of oxydative stress mechanisms in patients with KF in order to find more efficacious treatments. The influence of hemodialysis upon oxidative stress is not well known.

Official Title
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Redox State in the Course of Chronic Renal Insufficiency and Hemodialysis: Implications in Morbimortality

Conditions
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Chronic Renal Insufficiency

Intervention / Treatment
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* Other: Sampling of blood
* Other: Sampling of blood
* Other: Sampling of blood


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 and 80 years old man or woman dialysing at least 3 times a week for at least 6 months and having no residual renal function Rate of haemoglobin > 11 g / dl Clinically stable patient that is having had no considerable event (cardiovascular problem, infection, surgical operation) with the exception of angioplasty of fistula or prosthesis vascular, in the previous 3 months the entrance to the study Patient capable of understanding and of following the essay, in particular knowing how to read the note of information. Exclusion Criteria: Pregnant woman Treatment by corticoids or immunosuppresseurs hemopathy sly chronic cancer or infection in evolution Cardiovascular event (infarct, unstable angor, coronary bypasses, confusions of the rhythm, AVC, amputation) or infectious (blood-poisoning, pneumopathie, meningitis) or surgical operation in the previous 3 months the inclusion in the study.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: 1<br>Volunteer healthy | Other: Sampling of blood<br>* A sampling of blood will be made<br>|
| Other: 2<br>Patient dialysis patient | Other: Sampling of blood<br>* A sampling of bood will be made before the dialysis<br>|
| Other: 3<br>Not dialysed chronic renal insufficient patient | Other: Sampling of blood<br>* A sampling of blood will be made.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| This study should allow to clarify the redox state some plasma by quantification of thiols membranous on the surface of lymphocytes at the hemodialysis and insufficient renal chronic not dialysed patients. |  | 48 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| This study should allow to estimate in a forward-looking longitudinal plan the possible involvement of the parameters of the redox state and the morbidity and the cardiovascular and global mortality in 2 years in 2 studied populations. |  | 48 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Redox state in the course of chronic renal insufficiency and hemodialysis.