Effects of Aging and Aerobic Exercise Training on Brain Glucose Metabolism

Study Overview
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Brief Summary
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Aging is associated with a loss of brain function and conditions such as dementia and Alzheimer's disease. It is likely that decreased brain metabolism is contributing to the progression of age related degenerative diseases. Aerobic exercise training can increase brain volumes and is associated with decreased risk for degenerative brain conditions. However, little is know about the changes that occur to brain metabolism with aerobic training and aging.

Official Title
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Effect of Aging and Aerobic Exercise Training on Brain Glucose Metabolism

Conditions
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Dementia

Intervention / Treatment
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* Behavioral: High intensity aerobic training
* Behavioral: Sedentary Control


Participation Criteria
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Eligibility Criteria
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Healthy sedentary adults aged 18-30 or 65-80 years of all ethnicities will be eligible. Pregnant women, children, prisoners or other at risk populations will not be recruited. Inclusion Criteria: Age 18-30 years or 65-80 years Exclusion Criteria: Body mass index (BMI) >31 kg/m2 Smoking Pregnancy Participation in structured exercise (>2 times per week for 30 minutes or longer) Cardiovascular, metabolic (type 2 diabetes, fasting plasma glucose at or above 110 mg/dL and untreated hypo- or hyperthyroidism) or renal disease Orthopedic problems that would keep them from being able to ride an exercise bicycle, lift weights or do a combination of these exercise Medications that are known to impact on mitochondrial function: Corticosteroids, opiates, benzodiazepines, tricyclic antidepressants, beta blockers, sulfonylureas, insulin, anticoagulants, barbiturates, insulin sensitizers, fibrates (PPAR gamma agonist) Claustrophobia

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Exercise<br>Aerobic exercise | Behavioral: High intensity aerobic training<br>* High intensity aerobic interval training will be performed 12-weeks. Exercise training will last 1 hour per day, 5 days per week and include high intensity interval cycling at  70-95% maximum workload for 4 minutes followed by 3 minutes of rest.<br>Behavioral: Sedentary Control<br>* Sedentary control participants will not perform any regular exercise for 12-weeks.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Brain Glucose Uptake | The investigators will assess brain glucose uptake using positron emission tomography at baseline and following 12-weeks of either aerobic exercise training or sedentary control period. | 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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High intensity aerobic training