COVID-19 and Liver Injury in Patients With or Without Underlying Liver Disease: A Multi-centre Retrospective-prospective Observational Study

Study Overview
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Brief Summary
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COVID-19 and liver injury in patients with or without underlying liver disease: A multi-centre retrospective-prospective observational study. All patients infected with SARS-CoV-2 and admitted to the COVID-19 ward/ICU of Max Hospital Saket (either in East Wing , Max Super Specialty Hospital, Saket or MAX Smart Super Specialty Hospital, Saket) between 1/4/2020 to 30/6/2020 (retrospective data between 1/4/2020- 30/5/2020 & prospective data from approval till 30/6/2020), will be included

Detailed Description
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COVID-19 and liver injury in patients with or without underlying liver disease: A multi-centre retrospective-prospective observational study. All patients infected with SARS-CoV-2 and admitted to the COVID-19 ward/ICU of Max Hospital Saket (either in East Wing , Max Super Specialty Hospital, Saket or MAX Smart Super Specialty Hospital, Saket) between 1/4/2020 to 30/6/2020 (retrospective data between 1/4/2020- 30/5/2020 & prospective data from approval till 30/6/2020), will be included Primary objectives To study the prevalence of liver live injury & factors associated with among patients in-fected with SARS-CoV-2. To study the prevalence of new liver injury and factors associated with it, among patient with underlying liver disease who develops COVD-19. Secondary objectives To correlate the presence and degree of liver dysfunction with the clinical outcomes in these patients. To define the incidence of development of acute liver failure among these patients

Official Title
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COVID-19 and Liver Injury in Patients With or Without Underlying Liver Disease: A Multi-centre Retrospective-prospective Observational Study

Conditions
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COVID-19

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria:All patients infected with SARS-CoV-2 and admitted to the COVID-19 ward/ICU of Max Hospital Saket (either in East Wing , Max Super Specialty Hospital, Saket or MAX Smart Super Specialty Hospital, Saket) between 1/4/2020 to 30/6/2020 (retrospective data between 1/4/2020- 30/5/2020 & prospective data from approval till 30/6/2020), will be included. - Exclusion Criteria: Patients less that 18 years old with COVID-19 Pregnant ladies with COVD-19 Unwilling to give consent for inclusion

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| COVID-19 Positive Case | To study the prevalence of liver live injury & factors associated with among patients in-fected with SARS-CoV-2. | 4-8 weeks | 
| COVID-19 Positive Case | To study the prevalence of new liver injury and factors associated with it, among patient with underlying liver disease who develops COVID-19. | 4-8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| COVID-19 Positive Case | To correlate the presence and degree of liver dysfunction with the clinical outcomes in these patients. | 4-8 weeks | 
| COVID-19 Positive Case | To define the incidence of development of acute liver failure among these patients | 4-8 weeks |