The Effect of Ischemic Pre-Conditioning on the Rate of Recovery Following Exercise-Induced Muscle Damage

Study Overview
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Brief Summary
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Strenuous exercise or exercise involving eccentric muscle contractions can lead to muscle damage and changes in muscle function; this is known as exercise-induced muscle damage (EIMD). It is known that brief, repeated periods of ischemia followed by reperfusion, known as Ischemic Preconditioning (IPC) cause a delay in cell injury in cardiac muscle as well as in various other organs. Therefore the purpose of this study is to: Quantify the use of IPC in recovery following EIMD. Identify any effect of IPC during recovery on muscle function

Official Title
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The Effect of Ischemic Pre-Conditioning on the Rate of Recovery Following Exercise-Induced Muscle Damage: a Randomized Control Trial

Conditions
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Exercise-induced Muscle Damage

Intervention / Treatment
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* Other: Ischemic Preconditioning


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Physically Active Males Exclusion Criteria: Muscular skeletal disorders

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Ischemic Preconditioning<br>IPC (4 x 5 minute cycles @ 220 mmHg) with 5 min reperfusion between trials. | Other: Ischemic Preconditioning<br> <br> |
| Placebo Comparator: Ischemic Preconditioning Placebo<br>Placebo (4 x 5 minute cycles @ 20mmHg) with 5 minutes between each cycle | Other: Ischemic Preconditioning<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in maximal voluntary contraction | Isometric MVC of the participants' dominant knee extensors was assessed using a strain gauge. MVCs were performed for 3 s with a 60 s rest between each repetition. The change in MVC will be determined 24, 48 and 72 hours following pre exercise conditions. | pre exercise, 24 hours post, 48 hours post and 72 hours post exercise | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in Creatine kinase | Plasma CK was determined from an earlobe capillary blood sample. The sample (10 microlitres) was analysed immediately using an semi-automated clinical chemistry analyser. The change in CK will be determined 24, 48 and 72 hours following pre exercise conditions | pre exercise, 24 hours post, 48 hours post and 72 hours post exercise | 
| Change from baseline in Limb girth | Mid-thigh and calf circumference was assessed as a measure of limb swelling using an anthropometric tape measure. Both measures were obtained with the participant in a standing position. The change in limb girth will be determined 24, 48 and 72 hours following pre exercise conditions | pre exercise, 24 hours post, 48 hours post and 72 hours post exercise | 
| Chnage from baseline in Vertical jump | Vertical jump (VJ) performance was assessed using an electronic timing mat with hands placed on hips and participants dropping down to a self-selected level before jumping maximally. The change in VJ will be determined 24, 48 and 72 hours following pre exercise conditions | pre exercise, 24 hours post, 48 hours post and 72 hours post exercise | 
| Change from baseline in Muscle soreness | Muscle soreness - Participants were asked to perform and hold a squat (90° knee angle) whilst they rated their perceived muscle soreness on a 200 mm visual analogue scale. The scale consisted of a line from 0 mm (no pain) to 200 mm (unbearably painful). The change in muscle soreness will be determined 24, 48 and 72 hours following pre exercise conditions | pre exercise, 24 hours post, 48 hours post and 72 hours post exercise | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Investigate IPC on EIMD