The Use of Cyanoacrylate on Palatal Wound

Study Overview
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Brief Summary
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The palatal donor site of autogenous free gingival grafts significantly influences the patient's morbidity. The purpose of this study was to evaluate the efficacy of cyanoacrylate on palatal wound healing and postoperative complaints.

Detailed Description
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A total of 35 patients were included in the study. In the test group (19 patient), cyanoacrylate was placed over the palatal wounds; conversely, the 16 control group patients were allowed to heal in a conventional way without cyanoacrylate. Primary bleeding time, presence of secondary bleeding, postoperative pain and completion of epithelization were assessed following free gingival graft operation. As a result, compared to the control group it was determined that the cyanoacrylate tissue adhesive could reduce the postoperative morbidity and improve the wound healing.

Official Title
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The Efficacy of Cyanoacrylate on Palatal Wound Healing and Postoperative Complaints

Conditions
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Gingival Recession

Intervention / Treatment
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* Procedure: Free gingival graft
* Procedure: Cyanoacrylate application


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: no systemic diseases no coagulation disorders no drug intake in the previous 6 months that might effect the periodontal health status no pregnancy or lactation no smoking habit <1 mm attached gingiva width on one or two lower anterior teeth Miller Class I- II- III (Miller 1985) with deep gingival recession (˃ 3mm) Exclusion Criteria: Hematologic disorders No cooperation

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Periacryl group<br>Periacryl, a tissue adhesive, was applied on wound surfaces to achieve haemostasis | Procedure: Free gingival graft<br>* Free gingival graft was harvested from palatal donor site<br>Procedure: Cyanoacrylate application<br>* Periacyrl was applied on palatal wounds<br>|
| Active Comparator: Control group<br>Free gingival graft was harvested from palatal region and left to heal without applying periacryl. | Procedure: Free gingival graft<br>* Free gingival graft was harvested from palatal donor site<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Primary bleeding time | The moment of active blood flow stasis that a clinical photograph could be taken by examiner without need for suction. | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual Analog Scale (VAS) | The changes in postoperative pain level after the operation | 1-7 days after operation | 
| Analgesic consumption | The changes in the number of painkiller taken to relieve pain after the operation | 1-7 days after operation | 
| Completion of epithelization | The epithelization assessed by the peroxide test | Once a week for a month after the operation |