The Effect of Methylphenidate on Decision-making Ability of Attention Deficit Hyperactivity Disorder (ADHD) Adults

Study Overview
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Brief Summary
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The aim of the study is to assess the effect of Methylphenidate on cognitive performance and decision-making ability of ADHD adults, and to compare this effect to the effect on healthy control adults.

Detailed Description
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Two matched groups of adults - with and without ADHD diagnosis - will perform a battery of computerized tasks assessing sustained attention,working-memory,non-verbal IQ,and decision-making ability. In each group,half of the participants will perform the tasks after receiving a capsule containing methylphenidate (MPH), and the other half will perform the tasks after receiving placebo. Task performance measures will then be compared in order to assess the effect of MPH on these domains.

Official Title
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The Effect of Methylphenidate on Decision-making Ability of ADHD Adults

Conditions
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Attention Deficit Hyperactivity Disorder

Intervention / Treatment
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* Drug: methylphenidate
* Dietary Supplement: sweetener pill


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adults in the age of 21-50 Exclusion Criteria: pregnant or nursing women. people who suffer from a psychiatric disorder other than ADHD which could account for their inattention symptoms better than ADHD. people who lack judgment or are unable to communicate with the experimenters. people who are incapable of performing the computerized tasks due to sensory or motor disabilities.

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: ADHD -MPH<br>adults with ADHD diagnosis who receive a single dose of Methylphenidate | Drug: methylphenidate<br>* a single doses of 10-20 mg in each one of two visits<br>* Other names: Ritalin;|
| Placebo Comparator: ADHD-placebo<br>adults with ADHD diagnosis who received placebo | Dietary Supplement: sweetener pill<br>* a capsule containing a sweetener pill<br>* Other names: sukrazit;|
| Experimental: non-ADHD-MPH<br>healthy adults who received a single dose of Methylphenidate | Drug: methylphenidate<br>* a single doses of 10-20 mg in each one of two visits<br>* Other names: Ritalin;|
| Placebo Comparator: non-ADHD-placebo<br>healthy adults who received placebo | Dietary Supplement: sweetener pill<br>* a capsule containing a sweetener pill<br>* Other names: sukrazit;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| score in decision-making task 1 |  | by the end of the task | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| working memory task score |  | by the end of the task |