The Effect of Different Financial Competing Interest Statements on Readers' Perceptions of Clinical Educational Articles

Study Overview
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Brief Summary
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Financial ties with industry are common among doctors, academics and institutions. This trial aims to investigate the influence of different types of industry-linked activities on readers' perceptions of clinical reviews. Two clinical reviews have been selected on medical topics and study participants (practicing doctors) will be sent one review each. The reviews will be identical except for the inclusion of one of four different permutations of competing interest statements. Participants will be asked to rate the one review they are sent based on the study outcomes (confidence, interest, importance and likeliness to change practice). The study focus is on educational articles as these are intended to guide patient care and convey the authors' interpretation of selected data.

Official Title
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Randomised Controlled Trial to Measure the Effect of Different Financial Competing Interest Statements on Readers' Perceptions of Clinical Educational Articles

Conditions
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Healthy

Intervention / Treatment
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* Other: Variations of financial competing interest statements


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Practising doctors in the UK who are members of the British Medical Association (BMA) and receive The BMJ will be included. Exclusion Criteria: BMA members who have opted out of receiving a free copy of The BMJ, public health doctors, consultant oral/dental surgeons, consultants in private practice, retired doctors and student members will be excluded.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Review 1- competing interest statement 1<br>Variations of financial competing interest statements. There will be a statement that the authors have no competing interests. | Other: Variations of financial competing interest statements<br>* Participants will be randomised to receive 1 of 2 review articles on different topics. For each review there will be 4 groups. Each of the 4 groups will receive an identical version of the review article with the exception of the competing interest statement which will vary depending on group assignment.<br>|
| Experimental: Review 1- competing interest statement 2<br>Variations of financial competing interest statements. | Other: Variations of financial competing interest statements<br>* Participants will be randomised to receive 1 of 2 review articles on different topics. For each review there will be 4 groups. Each of the 4 groups will receive an identical version of the review article with the exception of the competing interest statement which will vary depending on group assignment.<br>|
| Experimental: Review 1- competing interest statement 3<br>Variations of financial competing interest statements. | Other: Variations of financial competing interest statements<br>* Participants will be randomised to receive 1 of 2 review articles on different topics. For each review there will be 4 groups. Each of the 4 groups will receive an identical version of the review article with the exception of the competing interest statement which will vary depending on group assignment.<br>|
| Experimental: Review 1- competing interest statement 4<br>Variations of financial competing interest statements. | Other: Variations of financial competing interest statements<br>* Participants will be randomised to receive 1 of 2 review articles on different topics. For each review there will be 4 groups. Each of the 4 groups will receive an identical version of the review article with the exception of the competing interest statement which will vary depending on group assignment.<br>|
| Experimental: Review 2- competing interest statement 1<br>Variations of financial competing interest statements. There will be a statement that the authors have no competing interests. | Other: Variations of financial competing interest statements<br>* Participants will be randomised to receive 1 of 2 review articles on different topics. For each review there will be 4 groups. Each of the 4 groups will receive an identical version of the review article with the exception of the competing interest statement which will vary depending on group assignment.<br>|
| Experimental: Review 2- competing interest statement 2<br>Variations of financial competing interest statements. | Other: Variations of financial competing interest statements<br>* Participants will be randomised to receive 1 of 2 review articles on different topics. For each review there will be 4 groups. Each of the 4 groups will receive an identical version of the review article with the exception of the competing interest statement which will vary depending on group assignment.<br>|
| Experimental: Review 2- competing interest statement 3<br>Variations of financial competing interest statements. | Other: Variations of financial competing interest statements<br>* Participants will be randomised to receive 1 of 2 review articles on different topics. For each review there will be 4 groups. Each of the 4 groups will receive an identical version of the review article with the exception of the competing interest statement which will vary depending on group assignment.<br>|
| Experimental: Review 2- competing interest statement 4<br>Variations of financial competing interest statements. | Other: Variations of financial competing interest statements<br>* Participants will be randomised to receive 1 of 2 review articles on different topics. For each review there will be 4 groups. Each of the 4 groups will receive an identical version of the review article with the exception of the competing interest statement which will vary depending on group assignment.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The Readers' Level of Confidence in the Conclusions Drawn in the Article. | Measured on a single-item 10-point Likert scale from (1) not at all confident to (10) extremely confident. Higher scores indicate more confidence. Min score = 0, max score =10. | Outcome measure will be assessed only at the time of the intervention (0 weeks). Readers will be asked to complete the study questionnaire immediately after reading the review article. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Importance of the Article. | Measured on a single-item 10-point Likert scale from (1) not at all important to (10) extremely important. Higher scores indicate more importance. Min score = 0, max score =10. Readers will be asked to complete the study questionnaire immediately after reading the review article. | Outcome measure will be assessed only at the time of the intervention (0 weeks) | 
| Interest in the Article. | Measured on a single-item 10-point Likert scale from (1) not at all interesting to (10) extremely interesting. Higher scores indicate more interest. Min score = 0, max score =10. Readers will be asked to complete the study questionnaire immediately after reading the review article. | Outcome measure will be assessed only at the time of the intervention (0 weeks) | 
| Number of Participants Who Are Extremely Likely to Change Practice on the Basis of the Article (Scored a 10), for Those Currently Treating the Relevant Condition | Measured on a single-item 10-point Likert scale from (1) not at all likely to (10) extremely likely. Higher scores indicate more likely to change practice. Min score = 1, max score =10. Readers asked to complete the study questionnaire immediately after reading the review article. | Outcome measure will be assessed only at the time of the intervention (0 weeks) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Readers' perceptions