Cetuximab and Radiation Therapy in Treating Patients With Locally Advanced Pancreatic Cancer That Cannot Be Removed by Surgery

Study Overview
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Brief Summary
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RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Radiation therapy uses high energy x-rays to kill tumor cells. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Giving cetuximab together with 3-dimensional conformal radiation therapy may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving cetuximab together with radiation therapy works in treating patients with locally advanced pancreatic cancer that cannot be removed by surgery.

Detailed Description
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OBJECTIVES: Primary To evaluate the progression free survival rate in patients treated with cetuximab and radiotherapy. Secondary To determine the response rate, toxicity of the combined regimen, and clinical benefit response in patients treated with cetuximab and radiotherapy. OUTLINE: Patients receive cetuximab IV over 1-2 hours once weekly for 6-7 weeks. Patients also undergo concurrent 3-dimensional image-guided conformal radiotherapy in 28-30 fractions over approximately 5.5-6 weeks (2-4 hours after administration of cetuximab). After completion of study treatment, patients are followed every 3 months for 1 year and then every 6 months for up to 3 years.

Official Title
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Locally Advanced Pancreatic Cancer: Phase II Study of Cetuximab and 3-D Conformal Image Guided Radiotherapy (PACER)

Conditions
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Pancreatic Cancer

Intervention / Treatment
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* Biological: cetuximab
* Radiation: 3-dimensional conformal radiation therapy


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Histopathologically or cytologically confirmed diagnosis of inoperable, non-metastatic, locally advanced pancreatic adenocarcinoma No neuroendocrine tumors or lymphoma of the pancreas No extensive disease unable to be covered in a radically treatable radiotherapy volume PATIENT CHARACTERISTICS: Karnofsky performance status 60-100% Life expectancy > 3 months Hemoglobin ≥ 10g/dL WBC ≥ 3,000/mm³ ANC ≥ 1,500/mm³ Platelet count ≥ 100,000/mm³ (prior transfusions for patients with low hemoglobin allowed) Total bilirubin ≤ 1.5 times upper limit of normal (ULN) ALT and AST ≤ 1.5 times ULN Alkaline phosphatase ≤ 1.5 times ULN Serum urea ≤ 1.5 times ULN Creatinine ≤ 1.5 times ULN Adequate biliary drainage with no evidence of active uncontrolled infection (patients on prophylactic antibiotics are eligible) Not pregnant or nursing Negative pregnancy test Women and men of child-bearing potential should be using an adequate contraception method, which must be continued for 3 months after completion of therapy No unresolved biliary tract obstruction No history of prior malignancy that may interfere with the response evaluation except for any of the following: Cervical carcinoma in-situ treated by cone-biopsy/resection Nonmetastatic basal and/or squamous cell carcinomas of the skin Any early stage (stage I) malignancy adequately resected for cure greater than 5 years previously No relative contraindication to radiotherapy No evidence of severe uncontrolled systemic diseases or laboratory finding that in the view of investigator makes it undesirable for the patient to participate in the trial No disorder likely to impact compliance with the protocol PRIOR CONCURRENT THERAPY: Must be completely recovered from previous surgery The following prior interventions are allowed: Non-curative operation (i.e., R2 resection with macroscopic residual disease evident on CT scan or palliative bypass procedure) Stent insertion in the common bile duct No previous radiotherapy within current treatment field No previous administration of EGF monoclonal antibodies, EGFR signal transduction inhibitors or EGFR-targeted therapy

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: cetuximab|nan|
|Radiation: 3-dimensional conformal radiation therapy|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression-free survival rate at 6 months |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Response rate by RECIST criteria |  |  | 
| Toxicity by NCI CTCAE criteria |  |  | 
| Clinical benefit response |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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adenocarcinoma of the pancreas, stage III pancreatic cancer