Interstitial Lung Disease Registry Construction

Study Overview
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Brief Summary
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The purpose of this study is investigating the clinical course, treatment course, and prognosis of patients with interstitial lung disease.

Detailed Description
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Interstitial lung disease refers to pulmonary disease that occurs in the interstitium of the lung. It can be broadly classified into lung disease secondary to the cause of systemic disease or drug, and lung disease whose cause is unknown, and the latter is known as idiopathic interstitial pneumonia. Idiopathic interstitial pneumonia is a lung disease showing various aspects of inflammatory response and fibrosis reaction, and the cause of the onset is not accurately known yet, also there is no effective treatment. Idiopathic interstitial pneumonia, including idiopathic pulmonary fibrosis, progresses very slowly, but sometimes acute exacerbation without any obvious cause leads to death, rapidly. Therefore, it is important to collect data prospectively for changes in clinical features, pulmonary function, imaging findings, and quality of life of these patients. A prospective study of idiopathic interstitial pneumonia will provide important information on the clinical characteristics and admission history of patients with idiopathic interstitial pneumonia, and the idiopathic interstitial pneumonia registry system will serve as the basis for further prospective observational studies. The aim of this study is to establish the registry of patients with interstitial lung disease and to prospectively review the clinical features and progression of the patients.

Official Title
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Interstitial Lung Disease Registry Construction

Conditions
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Interstitial Lung Disease

Intervention / Treatment
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* Other: monitoring changes in clinical symptoms, pulmonary function, and chest radiography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients older than 20 years diagnosed with interstitial lung disease Diagnostic criteria for interstitial lung disease. If one of the following is met: clinical suspicion of idiopathic pulmonary fibrosis (IPF); Characteristic chest CT findings with honeycomb cysts and fibrosis and reasonable clinical signs suspected interstitial pneumonia, or confirmed by biopsy with no evidence of infection : IPF, Non-specific interstitial pneumonia(NSIP), Cryptogenic organizing pneumonia(COP), unclassified fibrosis interstitial lung disease suspects with underlying rheumatic disease Exclusion Criteria: No specific criteria

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: monitoring changes in clinical symptoms, pulmonary function, and chest radiography|For patients with interstitial lung disease, the investigators regularly monitor changes in clinical symptoms, pulmonary function, and chest radiography after basic questionnaire on symptoms, lifestyle, depression, and quality of life.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| St George's Respiratory Questionnaire(SGRQ) | monitoring changes in clinical symptoms | at baseline, every 1 year through study completion for 10 years | 
| modified Medical Research Council (mMRC) dyspnea scale | monitoring changes in clinical symptoms | at baseline, after 1 month, after 3 month, and then every 1 year through study completion for 10 years | 
| Borg dyspnea scale | monitoring changes in clinical symptoms | at baseline, after 1 month, after 3 month, and then every 1 year through study completion for 10 years | 
| Hospital anxiety and depression score(HADS) | monitoring changes in clinical symptoms | at baseline, every 1 year through study completion for 10 years | 
| chest X-ray | monitoring changes in chest radiography | at baseline, after 1 month, after 3 month, and then every 1 year through study completion for 10 years | 
| Chest CT | monitoring changes in chest radiography | at baseline, every 1 year through study completion for 10 years | 
| Paranasal sinus X-ray(PNS series) | baseline PNS X-ray | at baseline | 
| Electrocardiogram(ECG) | baseline ECG | at baseline | 
| Pulmonary function test with bronchodilator response test(PFT+BDR) | monitoring changes in lung function | at baseline, after 1 month, after 3 month, and then every 1 year through study completion for 10 years | 
| Diffusing capacity of the lungs for carbon monoxide(DLCO) | monitoring changes in lung function | at baseline, after 1 month, after 3 month, and then every 1 year through study completion for 10 years | 
| total lung capacity(TLC) | monitoring changes in lung function | at baseline | 
| Bronchoscopic alveolar lavage(BAL) | for diagnostic purposes if necessary | at baseline | 
| Video-assisted thoracoscopic surgery(VATS) lung biopsy | for diagnostic purposes if necessary | at baseline | 
| echocardiography | additionally tested at acute exacerbation | at baseline | 
| arterial blood gas analysis(ABGA) | additionally tested at acute exacerbation | at baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Interstitial lung disease