Semitendinosus Graft as Meniscal Transplant

Study Overview
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Brief Summary
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Removal of meniscal tissue is described to result in poor knee function and a significant risk for future development of osteoarthritis. Different implants have been suggested to substitute a removed meniscus. Meniscal allograft transplantation is not widely available due to costs and availability. The semitendinosus tendon is a known graft with biological properties with potential to remodel and revascularize in an intraarticular environment such as anterior cruciate ligament reconstruction. The objective for this study was to investigate whether the semitendinosus tendon graft could function as a meniscal transplant.

Official Title
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Autologous Semitendinosus Tendon Graft as Meniscal Transplant - a Clinical Pilot Study

Conditions
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Patient Satisfaction, Graft Failure, Osteo Arthritis Knee, ACL, Meniscus Tear

Intervention / Treatment
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* Procedure: Surgical technique


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Previous subtotal or total meniscectomy Post meniscectomy symptoms No osteoarthritic changes on radiography more than Ahlbäck 1 Knee aligment (hip-knee-angle) +/- 3° No persisting ACL insufficiency Exclusion Criteria: Difficulty understanding the instructions Current psychiatric diagnosis Smoking

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Surgical technique|Description of novel surgical technique using autologous semitendinosus graft as meniscus transplant.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Failure | Surgical failure of transplant defined as meniscus symptoms (joint line tenderness, swelling, locking or positive McMurray) resulting in a need for re-arthroscopy and subtotal or total resection of the transplant. | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improved subjective knee function | Patient reported outcome measure using the Knee Injury and Osteoarthritis Outcome Score (KOOS), 0-100 where 100 indicate best possible result. | 2 years | 
| Improved subjective knee function | Patient reported outcome measure using Lysholm (0-100 where 100 indicate best possible result) and Tegner activity score (0-10, where 10 indicate the highest activity level) . | 2 years | 
| Improved subjective knee function | Patient reported outcome measure using Euroqol 5 dimensions (EQ-5D) score (quality of life instrument with five dimensions with points from 1 to 3 where 1 indicates no problem and 3 indicate severe problems). | 2 years | 
| Improved subjective knee function | Patient reported outcome measure using Global score (0-10 where 10 indicate best possible result) | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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meniscus transplantation