The Effect of General and Spinal Anesthesia on Neutrophil-to-lymphocyte Ratio

Study Overview
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Brief Summary
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The aim of the study was to evaluate the effects of anesthetic techniques (general and spinal anesthesia) on umbilical cord neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV) in patients undergoing cesarean section.

Detailed Description
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This study was designed to evaluate the effects of anesthetic techniques (general and spinal anesthesia) on umbilical cord NLR, PLR and MPV in patients undergoing cesarean section. The primary endpoint was to compare the effects of general and spinal anesthesia on umbilical cord NLR. Secondary endpoints were determined the general and spinal anesthesia on routine umbilical cord PLR, MPV and newborn Apgar scores at 1st and 5th min.

Official Title
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Comparison of the Effect of General and Spinal Anesthesia on Umbilical Neutrophil-to-lymphocyte Ratio, Platelet-to-lymphocyte Ratio and Mean Platelet Volume in Patients Undergoing Cesarean Section

Conditions
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Anesthesia, General, Anesthesia, Spinal, Umbilical Cord

Intervention / Treatment
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* Other: General anesthesia
* Other: Spinal anesthesia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 - 45 years American Society of Anesthesiology (ASA) II-III elective ceserean surgery Exclusion Criteria: declining to give written informed consent under 18 years of age or over 45 years of age factors affecting NLR, PLR and MPV such as preeclampsia, HELLP syndrome or premature rupture of membranes history of neurological and/or neuromucular disease cooperation cannot be established emergency surgery

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| General anesthesia group<br>Evaluate the effects of general anesthesia on NLR, PLR and MPV in patients undergoing cesarean section. | Other: General anesthesia<br>* Evaluate the effects of general anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.<br>|
| Spinal anesthesia group<br>Evaluate the effects of spinal anesthesia on NLR, PLR and MPV in patients undergoing cesarean section. | Other: Spinal anesthesia<br>* Evaluate the effects of spinal anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| neutrophil-to-lymphocyte ratio | Evaluate the effects of NLR in patients undergoing cesarean section | within 5 minute, following delivery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| platelet-to-lymphocyte ratio | Evaluate the effects of PLR in patients undergoing cesarean section | within 5 minute, following delivery | 
| mean platelet volume | Evaluate the effects of MPV in patients undergoing cesarean section | within 5 minute, following delivery | 
| Newborn Apgar score 1st minute | Appearance (skin color), Pulse (heart rate), Grimace (reflex irritability), Activity (tone), Respiration. Apgar score at 1st min (0-3: severely depressed, 4-6: moderately depressed, 7-10: excellent condition) | 1st minute after birth | 
| Newborn Apgar score 5th minute | Appearance (skin color), Pulse (heart rate), Grimace (reflex irritability), Activity (tone), Respiration. Apgar score at 1st min (0-3: severely depressed, 4-6: moderately depressed, 7-10: excellent condition) | 5th minute after birth | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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anesthesia, cesarean section, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, mean platelet volume