Backpack Carrying in Children With Cystic Fibrosis

Study Overview
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Brief Summary
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Cystic Fibrosis is a hereditary, chronic respiratory illness. Cystic Fibrosis leads to a progressive decline in lung function. School-aged children with cystic fibrosis experience backpack carrying everyday. Backpack carrying induce a restrictive effect responsible for lower lung function. Respiratory muscle strength is also impaired. No studies assessed aerobic capacities during children's gait while carrying a backpack. The investigators hypothesized that backpack carrying will induce an acute decline in lung function in children with cystic fibrosis compared to healthy children. Investigators also hypothesized that aerobic capacities will be impaired.

Official Title
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Impact of Backpack Position on Lung Function and Oxygen Consumption in School-aged Children With Cystic Fibrosis

Conditions
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Cystic Fibrosis

Intervention / Treatment
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* Behavioral: Backpack Carrying


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Cystic Fibrosis School-aged children (10 to 18) Exclusion Criteria: Backpack carrying contraindication Acute exacerbation Impossible gait Other respiratory disease (asthma ...)

Ages Eligible for Study
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Minimum Age: 10 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cystic Fibrosis children<br>Children with Cystic Fibrosis will experience lung function measurement while backpack carrying. Aerobic Capacities will also be assessed during treadmill gait. | Behavioral: Backpack Carrying<br>* A 12,5% of body weight backpack will be used for each measurement. Lung function will be assessed while carrying a double strap backpack, a mono shoulder backpack and without a backpack.<br>|
| Active Comparator: Healthy Children<br>Healthy Children will experience lung function measurement while backpack carrying. Aerobic Capacities will also be assessed during treadmill gait. | Behavioral: Backpack Carrying<br>* A 12,5% of body weight backpack will be used for each measurement. Lung function will be assessed while carrying a double strap backpack, a mono shoulder backpack and without a backpack.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lung Function (Forced Vital Capacity) |  | Immediate assessment while standing | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lung function (Forced Expiratory Volume in 1 second) |  | Immediate assessment while standing | 
| Respiratory Muscle Strength (MIP) | Maximal inspiratory pressure | Immediate assessment while standing | 
| Respiratory Muscle Strength (MEP) | Maximal expiratory pressure | Immediate assessment while standing | 
| Oxygen uptake (VO2) |  | During 12min treadmill gait | 
| Ratio Ventilation/VO2 (Ventilation equivalent for oxygen) | Number of liters of air must be ventilated to consume 1 Liter of O2 | During 12min treadmill gait | 
| Ratio Ventilation/VCO2 (Ventilation equivalent for carbon dioxide) | Number of liters of air must be ventilated to reject 1 Liter of CO2 | During 12min treadmill gait | 
| Dyspnea (Borg Scale) |  | During 12min treadmill gait | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cystic fibrosis, Backpack carrying, Respiratory function, Children