linjc16/ctgov huggingface dataset:
Efficacy of Naltrexone Treatment as Augmentation to SSRI in OCD Patients

Study Overview
=================
Brief Summary
-----------------
Assessing the efficacy of Naltrexone as augmentation to SSRI in patients with OCD

Conditions
-----------------
Obsessive Compulsive Disorder

Intervention / Treatment
-----------------
* Drug: Naltrexone


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of OCD Treatment with SSRI for at least 10 weeks with no response Exclusion Criteria: Suffering from any medical condition treatment with opiates chronic use of drugs Hepatitis or other liver related diseases Incapability to sign an informed consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Naltrexone|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
GamReg Sweden - Quality Register for Gambling and Gaming Disorders

Study Overview
=================
Brief Summary
-----------------
This is a quality register for the monitoring of clinical assessment and treatment for gambling disorder and gaming disorder in Swedish health care. This register is held by Region Skåne, the health care organization of Skåne in southern Sweden, and administered by Register center South, which is associated with health care services in the southern regions of Sweden (the establishment of quality registers in Swedish health care relies upon a national legislation). Quality registers by themselves do not represent formal research projects. However, future research projects can use quality registers, such as the present one, as a data source for future research projects in case they are approved by an ethics authority. Clinical study variables collected in the register include the following (examples): gender, age, occupation, living conditions if applicable, types of gambling associated with the treatment needs if applicable, type of problematic video gaming type of referral to the present treatment contact treatment history in psychiatry, social services, enforcement agency history of suicidal behavior alcohol and drugs problems requiring assessment or treatment violence victimization type of treatment provided to the patient

Official Title
-----------------
GamReg Sweden - Quality Register for Gambling and Gaming Disorders

Conditions
-----------------
Gambling Disorder, Gaming Disorder

Intervention / Treatment
-----------------
* Other: Observational health care register - no applicable intervention at present


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients assessed and treated at units where treatment of problem gambling or problem gaming is provided Exclusion Criteria: Patients who - in a standardized opt-out procedure (following standard of national regulation for quality registers) - refuse participation in the quality register

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Observational health care register - no applicable intervention at present|Observational health care register - no applicable intervention at present|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Treatment uptake | Number of patients treated (assessed annually) | 1 year | 
| Characteristics of treatment-seeking patients | Characteristics of treatment-seeking patients (socio-demographic and mental health co-morbidities), assessed annually | 1 year | 
| Distribution of treatment methods provided (assessed annually) | Distribution of treatment methods provided (cognitive-behavioral therapy, motivational interviewing, psycho-dynamic treatment, medication, etc, assessed annually) | 1 year |
Swallowing Disorders After Prolonged Mechanical Ventilation

Study Overview
=================
Brief Summary
-----------------
Epidemiology study for evaluation of incidence of swallowing disorders (SD) after prolonged invasive ventilation (more than seven days), using a clinical statement. All consecutive patients are screened, and clinical evaluation is performed during 48h after patient's extubation. If a SD exist, a new evaluation is realized 48h after. Three groups will be created (1.no SD, 2.transitory SD and 3.persistent SD (eg persistent after 48h)). Data complementary are notified at day 28 (pneumonia? nutritional status?)

Official Title
-----------------
Current Care Study of Incidence and Consequences of Swallowing Disorders After Invasive Mechanical Ventilation

Conditions
-----------------
Larynx Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: More than 7 days of invasive mechanical ventilation Exclusion Criteria: Age < 18 years old Preexistent swallowing disorders, stroke, tracheostomy Failure of patient's agreement

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of swallowing disorders after prolonged invasive ventilation |  | 48 hours after extubation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nutritional status at day 28 |  | day 28 |
Treatment Results on Patients With Debridement and Prosthesis Retention in the Hip

Study Overview
=================
Brief Summary
-----------------
This study presents the investigators results on patients treated for infection in the implemented hip prosthesis. Debridement and prosthesis retention is the method, followed by antibiotic treatment. The investigators present treatment results, predisposing factors and microbiological data.

Official Title
-----------------
Treatment Results on Patients With Debridement and Prosthesis Retention in the Hip 1997-2007

Conditions
-----------------
Infection, Debridement With Prosthesis Retention

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Infection in prothesis in hip treated with debridement and prosthesis retention Exclusion Criteria: Other technique

Ages Eligible for Study
-----------------
Minimum Age: 15 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Antibiotic therapy, Microbiological diagnosis
Empa PASS on Urinary Tract Malignancies

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to assess the risk of urinary tract malignancies in patients initiating empagliflozin (free or fixed dose combination) compared to patients initiating a dipeptidyl peptidase-4 (DPP-4) inhibitor and to patients initiating other Sodium glucose co-transporter-2 (SGLT-2) inhibitors (i.e. two comparator groups)

Official Title
-----------------
Post-authorisation Safety Study to Assess the Risk of Urinary Tract Malignancies in Relation to Empagliflozin Exposure in Patients With Type 2 Diabetes: a Multi-database European Study

Conditions
-----------------
Diabetes Mellitus, Type 2

Intervention / Treatment
-----------------
* Drug: empagliflozin
* Drug: DPP-4 inhibitors
* Drug: SGLT-2 inhibitors


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of type 2 diabetes Age over 18 years at index date At least 1 year of membership in the medication database prior to index date Exclusion Criteria: Patients with any cancer (excluding non-melanoma skin cancer) recorded at any time prior to the index date (i.e. during the available look-back time) Diagnosis of type 1 diabetes or other specific non-type 2 diabetes Use of any SGLT-2 inhibitor or any DPP-4 inhibitor (including free and fixed-dose combinations) recorded at any time prior to index date (i.e. during the available look-back time). Use of fixed-dose combinations of SGLT-2 inhibitors with DPP-4 inhibitors Diagnosis of end stage renal disease or receipt of renal dialysis recorded at any time prior to index date (i.e. during the available look-back time)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| type 2 diabetes patients<br> | Drug: empagliflozin<br>* drug<br>Drug: DPP-4 inhibitors<br>* drug<br>Drug: SGLT-2 inhibitors<br>* drug<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| occurence of urinary tract cancer | first incidence of urinary cancer | up to 60 months | 
| occurence of bladder cancer |  | up to 60 months | 
| occurence of renal cancer |  | up to 60 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| occurence of other urinary tract cancers | non-renal, non- urinary bladder, urinary tract cancers | up to 60 months |
BNP Guided Care in Addition to Multidisciplinary Care

Study Overview
=================
Brief Summary
-----------------
HF is associated with repeated hospitalisations and poor prognosis.The aim of this study is to investigate whether BNP-guided care (BGC) in addition to multidisciplinary management(MM) improves outcome compared to HNC alone or usual care (UC) for decompensated HF patients after discharge. Patients hospitalised with cardiac decompensation in 9 Viennese hospitals are randomised to BGC, MM alone, or UC. MM includes 2 consultations of a heart failure (HF) specialist 10 days and 2 months after discharge for recommending medical optimisation and care by a specialised HF nurse including 4 home visits and telephone contact. In addition, BGC includes intensified increase of medical treatment during repeated follow-up visits in a HF clinic in patients with an Nt-BNP level above 2200pg/ml at discharge.

Official Title
-----------------
NT-BNP Guided Care in Addition to Multidisciplinary Care in Patients With Chronic Heart Failure A Three-Arm, Prospective, Randomised Study

Conditions
-----------------
Decompensated Heart Failure

Intervention / Treatment
-----------------
* Procedure: BNP-guided care in addition to multidisciplinary management


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical signs and symptoms of cardiac decompensation during the present hospitalisation NYHA class III or IV at time of admission Cardiothoracic ratio > 0.5, and/or left ventricular ejection fraction <40% documented by echocardiography Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 19 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: BNP-guided care in addition to multidisciplinary management|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart failure rehospitalisation rate; |  |  | 
| combined endpoint death or heart failure rehospitalisation; |  |  |
Use of a Novel Weight Bearing Cone Beam Computed Tomography (CBCT) Scanner for Imaging of the Patellofemoral Joint

Study Overview
=================
Brief Summary
-----------------
Healthy volunteers will have a weight bearing cone beam CT scan of their knee to assess normal alignment of the knee joint

Official Title
-----------------
Use of a Novel Weight Bearing Cone Beam Computed Tomography (CBCT) Scanner for Imaging of the Patellofemoral Joint

Conditions
-----------------
Patellofemoral Joint

Intervention / Treatment
-----------------
* Device: Carestream Health Inc. weight bearing cone beam CT scanner


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Willing and able to provide written informed consent Be 16 or more years of age Subject is able to be positioned properly in the investigational device and be still during the exam to reduce the potential of motion during the images Exclusion Criteria: Have a history of patella instability Have had any type of previous knee surgery Have had a significant fracture of the patellofemoral joint Have a knee ligament injury Are pregnant at the time of screening or become pregnant during the study Have a history of high radiation exposure (i.e., undergone radiation therapy) Non-English speakers

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Carestream Health Inc. weight bearing cone beam CT scanner|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tibial tubercle-trochlear groove (TT-TG) offset distance (mm) |  | 1 day |
Feeding for Accesible, Affordable and Healthy Childhood

Study Overview
=================
Brief Summary
-----------------
The main objective of this study was to evaluate the effectiveness of implementing a healthy eating vs traditional recommendations on the Medkid index of children in primary school. To do so, different companies involved in ALINFA project developed with the assessment of UNAV, CNTA and UPNA, a healthy bi-weekly menu.

Official Title
-----------------
Feeding for Accesible, Affordable and Healthy Childhood

Conditions
-----------------
Healthy Children

Intervention / Treatment
-----------------
* Other: ALINFA
* Other: Control


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adequate cultural level and comprehension of the clinical study from the legal tutors. To agree in taking part of the study. Exclusion Criteria: Children presenting clinically relevant gastrointestinal malfunctions or structural anomalies, such as ulcers, chronic inflammatory diseases, etc. Even if they do not follow any pharmacological treatment at the moment of inclusion. Children with uncontrolled endocrine disorders. Children with any type of tumor/cancer within the last 5 years, or in current treatment. Children with any alimentary allergy. Children presenting any type of cognitive or psychic disorder Parents or legal tutors in which their future collaboration may not be the required, seen from the researchers' point of view.

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Control group<br>Subjects assigned to this arm will follow the habitual recommendations to develop skills for a healthy diet. No specific foods or cooking methods will be applied | Other: Control<br>* control group<br>|
| Experimental: ALINFA group<br>This group will receive, in addition to the usual recommendations, meals, and foods designed to increase the healthiness of the diet. Foods and meals have been designed to increase the fiber content, decrease sugars and saturated fats, and limit salt intake. | Other: ALINFA<br>* Comparing the usual recommendations with the healthy diet designed and developed<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dietary Pattern (questionnaire) | Evaluate differences in dietary pattern between groups | Baseline | 
| Dietary pattern (questionnaire) | Evaluate differences in dietary pattern between groups | 8 week | 
| Dietary pattern (questionnaire) | Evaluated changes in dietary pattern | Baseline vs 8 week |
The Effectiveness and Safety of the Trial of Labor in Full Term Pregnant Women With Cesarean Section After Spontaneous Labor

Study Overview
=================
Brief Summary
-----------------
This study is a multi-center, prospective, observational clinical trial study. 510 full-term pregnant women will be enrolled as subjects, and the ratio of eligible subjects in the two groups is 1:1. In the cesarean section group, full term pregnant women with one prior cesarean section after spontaneous labor who are willing to try the trial of labor after cesarean (TOLAC) and in accordance with the criteria according to the 2016 China vaginal birth after cesarean (VBAC) clinical management guidelines will be enrolled and recorded by our homemade registration form of TOLAC. In the non-cesarean section group, pregnant women after 37 weeks of gestation after spontaneous labor but without vaginal labor contraindications will be enrolled. After spontaneous labor for 24h, their final delivery mode will be recorded. In the following 42 days postpartum, their complications and the neonatal outcome will be followed up.

Official Title
-----------------
To Study the Effectiveness and Safety of the Trail of Labor in Full Term Pregnant Women With Cesarean Section After Spontaneous Labor: a Multi-center, Prospective, Observational Study

Conditions
-----------------
Trial of Labor After Cesarean, Vaginal Birth After Cesarean, Spontaneous Labor

Intervention / Treatment
-----------------
* Other: Non intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Volunteers sign the informed consent Age: 20-40 years; Singleton, a cephalic presentation; No contradiction to vaginal delivery; 5.39 42 weeks; 6.Spontaneous labor Exclusion criteria: Konwn contraindication to vaginal delivery or severe complications; Multiple gestation; Uterine malformation; Severe psychiatric disorder; Without family's support.

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cesarean section group<br> | Other: Non intervention<br>* If the vaginal delivery is failed after spontaneous labor for up to 24h, they will receive cesarean section<br>|
| Non-cesarean section group<br> | Other: Non intervention<br>* If the vaginal delivery is failed after spontaneous labor for up to 24h, they will receive cesarean section<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vignial birth rate | After spontaneous labor for up tp 24h, the mode of delivery will be konwn and recorded. | 24 hours |
Outcomes of the Use of CO2 (Carbon Dioxide) Laser in the Treatment of Chronic Anal Fissure

Study Overview
=================
Brief Summary
-----------------
Outcomes of using CO2 (Carbon Dioxide) laser in the management of chronic anal fissure as an alternative to conventional methods

Detailed Description
-----------------
The use of CO2 laser in management of chronic anal fissure as a new alternative technique. Interventional study of 236 patients. Comparison to other techniques was made with respect to pain scores and healing time.

Official Title
-----------------
Cohort Study of Chronic Anal Fissure Management Using CO2 Laser

Conditions
-----------------
Chronic Anal Fissure

Intervention / Treatment
-----------------
* Device: Laser surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Have chronic anal fissure Exclusion Criteria: Acute anal fissure Pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 26 Years
Maximum Age: 58 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Patients with chronic anal fissure<br>Use of laser in surgery of chronic anal fissure instead of the conventional surgical techniques. | Device: Laser surgery<br>* Use of CO2 laser to perform surgeries to treat chronic anal fissure<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain score after surgery (Degree of pain) | Record pain after surgery on a scale of 1 to 10 (Range 1-10 with 1 being least pain and 10 greatest pain experienced by patients) | 3 weeks after surgery | 
| Recovery time after surgery (How many days patient takes to recover) | Time (How many days) for patient to be able to return to normal life activities after surgery | 3 weeks | 
| Incontinence after surgery | Lack of control of anal sphincter (Incontinence) | 2 years |