Adductor-Canal-Blockade Versus the Femoral Nerve Block Effect on Muscle Strength and Mobilization in Healthy Volunteers

Study Overview
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Brief Summary
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The aim of this study is to investigate the efficacy of the Adductor-Canal-Blockade versus the femoral nerve block versus placebo on muscle strength in healthy volunteers. The investigators hypothesize that the Adductor-Canal-Blockade results in a lesser reduction of the quadriceps muscle strength compared to the femoral nerve block.

Official Title
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Comparison of the Efficacy of the Adductor-Canal-Blockade Versus the Femoral Nerve Block on Muscle Strength and Mobilization in Healthy Volunteers: a Randomized Study

Conditions
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Muscle Strength, Healthy Volunteers

Intervention / Treatment
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* Procedure: Adductor-Canal-Blockade
* Procedure: The femoral nerve block
* Procedure: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: written informed consent ASA 1 BMI > 18 og < 25 Exclusion Criteria: Can not cooperate to the exam Do not speak or understand Danish Drug allergy Alcohol or drug abuse Daily consumption of analgetics on prescription Any drug intake within the last 48 hours Neuromuscular defects in the femoral nere, the obturator nerve or the muscles of the thigh. Previous surgery or trauma to the lower limb Diabetes Mellitus Intake of steroids, except steroids for inhalation Physical exercise within the last 24 hours prior to Day 1 and 2 of the study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Adductor-Canal-Blockade<br> | Procedure: Adductor-Canal-Blockade<br>* US-guided Adductor-Canal-blockade with Ropivacaine<br>|
| Active Comparator: The femoral nerve block<br> | Procedure: The femoral nerve block<br>* US-guided femoral nerve block with ropivacaine<br>|
| Placebo Comparator: Placebo<br> | Procedure: Placebo<br>* US-guided Adductor-Canal-Blockade/femoral nerve block with saline<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the difference in quadriceps muscle strength between the Adductor-Canal-Blockade and placebo |  | 0-6 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The difference in quadriceps muscle strength between the Adductor-Canal-Blockade and the femoral nerve block |  | 0-6 hours | 
| The difference in quadriceps muscle strength between the placebo and the femoral nerve block |  | 0-6 hours | 
| The difference in adductor muscle strength between the groups |  | 0-6 hours | 
| The difference in mobilization between the groups |  | 0-6 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Adductor-Canal-blockade,, human volunteers,, US-guided nerve block, femoral nerve block