Heart Rate Variability in Trauma Patients

Study Overview
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Brief Summary
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The purpose of this study is to develop new triage tool for trauma patients based on HRV. EKG will be prospectively measured in trauma patients in two locations: in the prehospital setting (the field and during transport by helicopter) and in the hospital setting. In each case HRV will be derived from the EKG signal, will be correlated with other non-invasive signals (e.g. near infrared spectroscopy (NIR), and bispectral EEG (BIS)), along with other routinely measured variables (blood pressure, respiratory rate, pulse oximetry, etc), will be correlated with injury severity and day of discharge. An algorithm will be constructed using multiple linear regression. The hypotheses are: reduced HRV in the field correlates with bad outcome; the specificity and efficiency of HRV as a screening tool can be improved by controlling factors such as heart rate, age, gender, respiratory rate, and pulse oxygen saturation; an easy to interpret HRV index can be derived that can be used for trauma triage or diagnosis.

Detailed Description
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The eligible study population will be comprised of patients who meet level 1 trauma criteria and are transported by helicopter to Ryder Trauma Center or who are already admitted to the trauma center for presumptive traumatic brain injury. In addition to the EKG, trauma patients may also be connected to either an non-invasive NIR Monitor, which provides real-time information about perfusion status and/or a bispectral EEG monitor, which provides real-time information about brain metabolic activity.

Official Title
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Heart Rate Variability in Trauma Patients

Conditions
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Trauma

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who meet level 1 trauma criteria and are transported by helicopter to Ryder Trauma Center An additional study population will be comprised of patients already admitted to the trauma center for presumptive Traumtaic Brain Injury Exclusion Criteria: None

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Base Deficit </= -6 | Indicator for volume deficit and resuscitation. Number of participants with Base Deficit </= -6 is reported. Base deficit is the absolute difference of the base deficit from its normal range (-2 to 2), and is used as an indicator for traumatic injuries. A base deficit </= - 6 signifies volume deficit and the need for volume resuscitation with fluids, blood or blood products either alone or in combination. | Upon arrival to the hospital | 
| Serious Injury | A patient was classified as seriously injured when two of three blinded trauma surgeons classified the patient as similar after review of each patient chart and final diagnoses in retrospect. | Upon arrival to the hospital | 
| Life Saving Intervention in the Operating Room. | A patient was classified as having a life saving intervention in the operating room when two of three blinded trauma surgeons classified the patient as similar after review of each patient chart and final diagnoses in retrospect. | Upon arrival to the hospital | 
| SDNN: Standard Deviation of the Normal-to-normal R-R Interval | A determination of HRV derived from the time domain of a standard electrocardiogram, primarily determined by measuring the randomness of the exact occurrence of when one R wave follows a preceding R wave. | Upon arrival to the hospital | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Injury