Iowa Fluoride Study/Iowa Bone Development Study

Study Overview
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Brief Summary
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A cohort of newborns was recruited for the Iowa Fluoride Study from 1992-95 to assess the complex relationships among fluoride intakes, fluoride exposures, dental fluorosis, and dental caries. Detailed questionnaires were sent every 1.5-6 months concerning water sources, fluoride exposures, dietary intakes, etc. Standardized dental exams were conducted at  ages 5, 9, 13, 17, and 23. At about age 5, participants were invited to join the offshoot Iowa Bone Development Study. Bone densitometry assessments were conducted at ages 5, 8, 11, 13, 15, 17, 19, and 23. These included Dual-energy X-ray Absorptiometry (DXA) of hip, lumbar spine, and whole body from age 5; peripheral Quantitative Computed Tomography (pQCT) of the radius and tibia from age 11; and Multi-Detector Computed Tomography (MDCT) of the tibia from age 19. Physical activity and other factors also were assessed longitudinally.

Detailed Description
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A cohort of newborns was recruited for the Iowa Fluoride Study from 1992-95 to assess the complex relationships among fluoride intakes, fluoride exposures, dental fluorosis, and dental caries. Detailed questionnaires were sent every 1.5-6 months concerning water sources, fluoride exposures, dietary intakes, etc. Standardized dental exams were conducted at  ages 5, 9, 13, 17, and 23. At about age 5, participants were invited to join the offshoot Iowa Bone Development Study. Bone densitometry assessments were conducted at ages 5, 8, 11, 13, 15, 17, 19, and 23. These included Dual-energy X-ray Absorptiometry (DXA) of hip, lumbar spine, and whole body from age 5; peripheral Quantitative Computed Tomography (pQCT) of the radius and tibia from age 11; and Multi-Detector Computed Tomography (MDCT) of the tibia from age 19. Physical activity and other factors also were assessed longitudinally.

Official Title
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Iowa Fluoride Study/Iowa Bone Development Study

Conditions
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Dental Caries, Dental Fluoroses, Bone Density

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy newborn Exclusion Criteria: not health newborn

Ages Eligible for Study
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Minimum Age: 1 Month
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Parents with newborns recruited from 1992-5<br>Parents of newborns recruited from 8 Iowa hospitals in 1992-5 | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| dental fluorosis-5 | dental fluorosis exam results | age 5 | 
| dental fluorosis-9 | dental fluorosis exam results | age 9 | 
| dental fluorosis-13 | dental fluorosis exam results | age 13 | 
| dental fluorosis-17 | dental fluorosis exam results | age 17 | 
| dental fluorosis-23 | dental fluorosis exam results | age 23 | 
| dental caries-5 | dental caries exam results | age 5 | 
| dental caries-9 | dental caries exam results | age 5 | 
| dental caries-13 | dental caries exam results | age 9 | 
| dental caries-17 | dental caries exam results | age 17 | 
| dental caries-23 | dental caries exam results | age 23 | 
| bone densitometry-5 | DXA scans | age 5 | 
| bone densitometry-8 | DXA scans | age 8 | 
| bone densitometry-11 | DXA and pQCT scans | age 11 | 
| bone densitometry-13 | DXA and pQCT scans | age 13 | 
| bone densitometry-15 | DXA and pQCT scans | age 15 | 
| bone densitometry-17 | DXA and pQCT scans | age 17 | 
| bone densitometry-19 | DXA, pQCT, and MDCT scans | age 19 | 
| bone densitometry-23 | DXA, pQCT, and MDCT scans | age 23 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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fluoride, genetics, physical activity, diet