linjc16/ctgov huggingface dataset:
Comparison Between Injection Molded PEEK Framework and Cobalt Chromium Framework in Removable Partial Denture Regarding Retention

Study Overview
=================
Brief Summary
-----------------
This study is aiming to evaluate the retentive forces in PEEK framework RPD compared to Cobalt-Chrome framework RPD during attachment/detachment cycles in mandibular kennedy class I edentulous cases

Official Title
-----------------
Evaluation of Retention of Partial Denture Made of Injection Molded PEEK Framework Versus Cobalt Chromium Framework in Mandibular Kennedy Class I Edentulous Cases

Conditions
-----------------
Mandibular Prosthesis User

Intervention / Treatment
-----------------
* Device: peek framework RPD
* Device: cobalt chromium framework RPD


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: . kennedy class I edentulous subjects indicated for framework partial denture Exclusion Criteria: Uncooperative patients and bad oral hygiene patients
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: peek framework Removable partial denture<br>polymer-based framework has recently been introduced which is made of polyetheretherketone polymer frame combined with acrylic resin denture teeth and a conventional acrylic resin denture base. | Device: peek framework RPD<br>* it is a polyetheretherketone polymer frame combined with acrylic resin denture teeth and a conventional acrylic resin denture base made by injecting technique and have several advantages regarding strength and esthetics<br>|
| Active Comparator: cobalt chromium framework Removable partial denture<br>it's the gold standard framework which has many benefits such as they are used in thin sections and are less bulky,provide high strength and stiffness,and some disadvantages include hypersensitivity,metal display and oral galvanism, | Device: cobalt chromium framework RPD<br>* standard framework device<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Retention | retention force of RPD during attachment/detachment cycles measured by digital force meter device | change from baseline retention force after one month and after three months |
Prospective and Obsevational Study of Total Hip Prothesis: HYPE Stem

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to validate the performance and the safety of the HYPE (SERF) prothesis in compliance with the 93/42/EEC directive and in relation to the recommendations of the MEDDEV 2.7.1 guide ( guideline for post-market follow-up), which provides for the implementation of a systematic procedure for the follow-up of clinical data in order to verify the performance claimed for medical devices .

Official Title
-----------------
Study of the Total Hip Prosthesis With a HYPE Stem in Hip Arthroplasty

Conditions
-----------------
Hip Arthropathy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Man or women Degenerative or inflammatory hip pathology requiring a total hip replacement Primary or secondary osteoarthritis Advanced joint destruction resulting from rhumatoid arthritis or traumatic arthritis Fracture or avascular necrosis Sub-capital fracture and displaced transcervical as well as for bone defects stages I to IIb of PAPROSKY Traumatic joint destruction Following previous intervention, provided that the new device does not interfere with the material in place (osteosynthesis, joint reconstruction, arthrodesis, hemi-arthroplasty, total arthroplasty Exclusion Criteria: People with diminished mental faculties Known current pregnancy Breast-feeding Neurological disorders or other pathologies that may influence locomotion Septic antecedent on hip to operate Patient requiring a bone graft

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assess the Survival rate to Total Hip Prothesis combining a HYPE stem and a SERF cup in hip replacements | Survival according to Kaplan Meier | per operative period to 10 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assess the improvement in PMA scores and HHS score as well as patient satisfaction |  | per operative period to 10 years | 
| Adverse events | Type and occurrence of adverse events | per operative period to 10 years | 
| Patient satisfaction |  | per operative period to 10 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Total Hip Prothesis
A Study to Demonstrate the Efficacy and Safety of Motilitone®

Study Overview
=================
Brief Summary
-----------------
This is a phase IV , comparative study to evaluate the efficacy and safety of Motiltone® in treatment of the patients with functional dyspepsia. The study is conducted with following methods: multi-centers, double blind, randomization, parallel. The subjects will receive Motilitone® or/and Pantoline®.

Official Title
-----------------
A Multi-centers, Randomized, Double-blinded, Parallel Study Study to Evaluate the Efficacy and Safety of Motilitone® in Patients With Functional Dyspepsia.

Conditions
-----------------
Functional Dyspepsia

Intervention / Treatment
-----------------
* Drug: Motilitone ®
* Drug: Pantoline®
* Drug: Motilitone® and Pantoline®


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Roman III criteria One or more conditions are applied: epigastralgia, burning feelings in the solar plexus early satiety, uncomfortable fullness No organic lesion Exclusion Criteria: has been administered or was administered within a month had a surgery that might affect gastrointestinal motility Tegaserod

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Motilione®<br>30 mg is administered with a tablet of placebo (Pantoline®) | Drug: Motilitone ®<br> <br> |
| Active Comparator: Pantoline®<br>40mg is administered with a tablet of Motilitone® | Drug: Pantoline®<br> <br> |
| Active Comparator: Motilitone® and Pantoline®<br>Both drugs are administered at once | Drug: Motilitone® and Pantoline®<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Subject global assessment by using 5-Likert scale and Binary outcome methods | 5-Likert scale: 0: worse similar improved in some degree considerably improved completely cured Binary outcome: yes/no | 6 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of dyspepsia(indigestion) symptoms occurred (Counted daily) |  | 6 weeks | 
| Assessment of NDI-K Quality of Life |  | 6 weeks | 
| Soreness of digestive symptoms (dyspepsia) evaluated its intensity on a scale of 1 to 5 |  | 6 weeks |
The Metabolic Road to Diastolic Heart Failure: Diastolic Heart Failure Study

Study Overview
=================
Brief Summary
-----------------
The main objective is to replicate the validation of omics biomarkers of left ventricular diastolic dysfunction in patients with metabolic syndrome. The aim was to recruit overall 750 patients in Europe (100 for France). Currently, 625 patients were enrolled in Europe and 47 in France.

Official Title
-----------------
The Metabolic Road to Diastolic Heart Failure : Diastolic Heart Failure Study (MEDIA-DHF)

Conditions
-----------------
Diastolic Heart Failure

Intervention / Treatment
-----------------
* Other: Blood sampling for biomarker assessment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients 18 years of age or older Signs or symptoms of HF Able and willing to provide freely given written informed consent including analysis of genomics Exclusion Criteria: Patients with acute myocardial infarction Recent trauma or surgery (< 3 months) Hemodynamically significant valvular disease Serious cerebrovascular disease or stroke in the last 3 months Chronic dialysis Chronic liver disease Chronic infectious (bacterial or viral) disease Any malignant concomitant diseases or a malignant disease in the last 5 years Systemic inflammatory diseases, such as autoimmune diseases, connective tissue diseases or collagenoses Pregnant women

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Diastolic heart failure cohort<br>This is a prospective cohort of patients with diastolic heart failure. Blood sampling for biomarker assessment | Other: Blood sampling for biomarker assessment<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiovascular Hospitalizations or Cardiovascular Death |  | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiovascular Hospitalizations |  | 3 months, 6 months, 12 months | 
| Heart Failure Hospitalizations |  | 3 months, 6 months, 12 months | 
| Other cardiovascular hospitalizations |  | 3 months, 6 months, 12 months | 
| Non cardiovascular hospitalizations |  | 3 months, 6 months, 12 months | 
| Cardiovascular Death |  | 3 months, 6 months, 12 months | 
| Non cardiovascular Death |  | 3 months, 6 months, 12 months |
New Technique For Laparoscopic Appendicectomy

Study Overview
=================
Brief Summary
-----------------
Introduction: Appendectomy is one of the most frequent emergency surgical procedures, currently with a preference for laparoscopic management worldwide. Objective: To report a new laparoscopic appendectomy technique and its results. Material and methods: study of patients with a diagnosis of appendicitis who are managed laparoscopically. In a total 1063 patients, 148 were operated on with the Zaragoza technique during the period from January 2002 to December 2018. The technique consists of making a window in the appendicular base between the meso and the appendicular wall, two prolene or silk sutures are placed, and the cecal appendix is cut between the two sutures, finally the mesoappendix is sectioned with a harmonic scalpel or bipolar clamp.

Detailed Description
-----------------
this is a retrospective study based on files

Official Title
-----------------
Zaragoza Technique For Laparoscopic Appendicectomy

Conditions
-----------------
Appendicitis Acute

Intervention / Treatment
-----------------
* Procedure: APPENDICECTOMY


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with a diagnosis of appendicitis who are managed laparoscopically. Exclusion Criteria: Less than 18 year old

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: APPENDICECTOMY|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| success of surgery | this study was revision of clinical files. measured by the rate of infection at the surgical site, mortality and hospital stay | 2002-2018 |
(PEEK) Housing Verses Metallic Housing of Ball and Socket Attachment on Retention of Mandibular Overdenture

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to compare the clinical effect of PEEK housing vs. metal housing in terms of retention and patient satisfaction

Official Title
-----------------
Effect of Polyether Ether Ketone (PEEK) Housing Verses Metallic Housing of Ball and Socket Attachment on Retention of Mandibular Implant Retained Overdentures: Randomized Clinical Trial

Conditions
-----------------
Problem With Dentures

Intervention / Treatment
-----------------
* Other: Overdenture


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient should be free from any systemic disease that may interfere with dental implants placement and/or osseointegration e.g. uncontrolled diabetes, hypertension, blood diseases, bone diseases, smoking.etc. Patients have completely edentulous upper and lower arches. Patients have healthy mucosa free from any ulceration, inflammation or infections. All patients are free from neuromuscular and temporomandibular joint disorders. Selected patients have normal maxillo-mandibular relationship (Angle class I ridge classification) with adequate inter-arch space and normal tongue size. Exclusion Criteria: Patients with limited manual dexterity. Patients with Xerostomia, excessive salivation or pathological mucosal changes (e.g. Lichen planus, Leukoplakia…etc.) Pregnant females. Un co-operative patients.

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Metal housing<br>metal housing of ball and socket attachment the intervention will be overdenture | Other: Overdenture<br>* Active comparator will be metal housing and peek housing<br>* Other names: Implant supported overdenture;|
| Active Comparator: Peek housing<br>Peek housing of ball and socket attachment the intervention will be overdenture | Other: Overdenture<br>* Active comparator will be metal housing and peek housing<br>* Other names: Implant supported overdenture;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Retention of implant supported overdenture by using digital force meter device |  | 3 months |
Customized Polyamide Prosthesis. for Mid Shaft Clavicle Fracture

Study Overview
=================
Brief Summary
-----------------
Herein we describe the management of a patient who presented with progressive brachial plexopathy following the initial nonoperative management of a mid shaft clavicular fracture by using 3 D customized polyamide prosthesis.

Detailed Description
-----------------
we made surgery to fix the new polyamide prosthesies in the clavicle.

Official Title
-----------------
New Polyamide Prosthesis for Treatment of Non-union Mid Shaft Clavicle Fracture: A Case Report

Conditions
-----------------
Treatment Adherence and Compliance

Intervention / Treatment
-----------------
* Other: new prosthesis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: fracture midshaft clavicle Exclusion Criteria: normal clavicle
Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: prosthesis<br>The polyamide prosthesis | Other: new prosthesis<br>* Operation to fix the new prosthesis<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| American shoulder and elbow surgeons score Special Score for shoulder pain and function | American shoulder and elbow surgeons score Special Score for shoulder pain and function. The American shoulder and elbow surgeons score is a composite instrument, requiring both a physician assessment and a patient-completed portion. . This includes a section on pain (7 items) and a section on activities of daily living (10 items). Scores range from 0 to 100 with a score of 0 indicating a worse shoulder condition and 100 indicating a better shoulder condition. Intensity of pain: 0; Putting on a coat is not difficult; Sleeping on the affected side is not difficult; Washing my back/doing up my bra is not difficult; Managing toiletting is not difficult; Combing my hair is not difficult; Reaching a high shelf is not difficult; Lifting 10lbs. (4.5kg) above my shoulder is not difficult; Throwing a ball overhand is not difficult; Doing my usual work is not difficult; Doing my usual sport/leisure activity is not difficult; It means good shoulder | after 2 and half years |
Computer-Based Training for Mild Alzheimer's Disease

Study Overview
=================
Brief Summary
-----------------
The primary objective of this study is to evaluate the effects of computer-based training program (HiFi-AD) on the memory and cognitive abilities of individuals diagnosed with mild Alzheimer's Disease (AD).

Detailed Description
-----------------
The purpose of this study is to determine the extent to which computer-based cognitive remediation improves cognitive functions using standardized neuropsychological assessments relevant to AD; 2) the acceptability and feasibility of using computer-based cognitive remediation in an AD population.

Official Title
-----------------
Computer-Based Training for Mild Cognitive Impairment and Mild Alzheimer's Disease

Conditions
-----------------
Alzheimer's Disease

Intervention / Treatment
-----------------
* Procedure: Computer-based Cognitive Training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Fluent in English. Mini-Mental Status Examination (MMSE) score of 22 or higher. Adequate visual capacity. Adequate hearing capacity. Has a caregiver with some computer experience. Willing and able to commit to the time requirement of the entire study. Exclusion Criteria: Clinically significant cerebrovascular disease. Participant is planning to begin acetylcholinesterase inhibitor (AChEI) therapy. Participants with severe tremor. Axis 1 or 2 psychiatric disorders. History of substance abuse. History of head trauma.

Ages Eligible for Study
-----------------
Minimum Age: 60 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Computer-based Cognitive Training|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The primary objective of this trial will be to assess the feasibility of using computer-based |  |  | 
| cognitive training in an a population with early Alzheimer's Disease. |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| A standardized set of neuropsychological assessments will be conducted pre- and post- |  |  | 
| compuer-based training. |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Alzheimer's, AD, Mild Cognitive Impairment, Dementia, Cognitive remediation, computer-based training
Influence of Trigger Threshold on Controlled Twitch Mouth Pressure

Study Overview
=================
Brief Summary
-----------------
The inspiratory pressure trigger is essential when assessing the twitch mouth pressure (Tw Pmo) for avoiding glottic closure. However, the difference in inspiratory pressure trigger threshold may influence the values of Tw Pmo. We sought to determine the trigger threshold for healthy subjects and COPD patients.

Official Title
-----------------
Influence of Trigger Threshold on Controlled Twitch Mouth Pressure

Conditions
-----------------
COPD, Healthy

Intervention / Treatment
-----------------
* Procedure: twitch by magstim


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical diagnosis of COPD Stable with no episodes of exacerbation within the previous 2 months Do not currently being treated with oral corticosteroids Exclusion Criteria: Not stable within the previous 2 months. Patients with COPD were currently being treated with oral corticosteroids

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: COPD patients<br>All of the COPD patients included in this study were stable with no episodes of exacerbation within the previous 2 months. Patients with COPD were not currently being treated with oral corticosteroids. | Procedure: twitch by magstim<br> <br> |
| Experimental: normal subjects<br>Fifteen healthy men with normal lung function | Procedure: twitch by magstim<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Twitch mouth pressure |  | 2 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Twitch oesophageal pressure |  | 2 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Normal, subjects