Applying Pulse Wave Analysis to Predict Intradialytic Hypotension

Study Overview
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Brief Summary
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Intradialytic hypotension (IDH) is a common complication during hemodialysis in patients with chronic kidney disease and may increase the mortality. This study aimed to investigate whether pulse wave analysis could be the predictor of IDH. In this study, patients under regular hemodialysis were enrolled from Taoyuan Chang Gung memorial hospital. Subjects were evaluated by pulse wave instrument, heart rate variability analyzer and Constitution in Chinese Medicine Questionnaire before hemodialysis. According to the definitions of IDH, subjects in study group and control group were confirmed by the dialysis records. Furthermore, repeated examinations were done for 3 hemodialysis to investigate the possible predictive factors for IDH.

Detailed Description
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Intradialytic hypotension (IDH) is a common complication during hemodialysis in patients with chronic kidney disease and may increase the mortality. This study aimed to investigate whether pulse wave analysis could be the predictor of IDH. In this study, patients under regular hemodialysis were enrolled from Taoyuan Chang Gung memorial hospital. Subjects were evaluated by pulse wave instrument, heart rate variability analyzer and Constitution in Chinese Medicine Questionnaire before hemodialysis. According to the definitions of IDH, subjects in study group and control group were confirmed by the dialysis records. Furthermore, repeated examinations were done for 3 hemodialysis to investigate the possible predictive factors for IDH.

Official Title
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Applying Pulse Wave Analysis to Predict Intradialytic Hypotension

Conditions
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Intradialytic Hypotension

Intervention / Treatment
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* Diagnostic Test: intradialytic hypotension episode


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients under regular hemodialysis (3 times per week) in last 3 months Exclusion Criteria: arrhythmia artery-vein anastomoses on both arms other conditions which might interfere the evaluation of pulse wave analysis and heart rate variability analysis

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Intradialytic hypotension<br>subjects with intradialytic hypotension episode | Diagnostic Test: intradialytic hypotension episode<br>* Intradialytic hypotension episode under regular hemodialysis<br>|
| Non-intradialytic hypotension<br>subjects without intradialytic hypotension episode | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pulse wave analysis | Pulse wave analysis | within 2 hours before regular dialysis | 
| Heart rate variability | Heart rate variability | within 2 hours before regular dialysis | 
| Constitution in Chinese Medicine Questionnaire | Constitution in Chinese Medicine Questionnaire | within 2 hours before regular dialysis | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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intradialytic hypotension, pulse wave analysis, heart rate variability, Constitution in Chinese Medicine Questionnaire