Review of Human Herpes Viruses in Burns

Study Overview
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Brief Summary
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Herpes simplex virus, cytomegalovirus and varicella zoster virus infection are purported to play a pivotal role in morbidity and mortality in burns. Thus far, there is no existing systematic review (Level of Evidence III or higher) describing the unique role as well as concurrent infections of these viruses in burns. The aim of this review is to point out the clinical differences between these human herpes virus subtypes, to outline established therapy approaches, and to provide evidence for virus related morbidity and mortality in burns.

Detailed Description
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This systematic review was created according the PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist. We performed an review of the medical literature to identify all studies that contain HSV, CMV and VZV infections in burns.Therefore, systematic review of the Medline database by using PubMed and Ovid interface was conducted. Also the Web of Science interface was used for systematic literature search. On the PubMed interface, we used the following search terms: (HSV[All Fields] OR herpes[All Fields] OR CMV[All Fields] OR cytomegalovirus[All Fields] OR VZV[All Fields] OR varicella-zoster[All Fields]) AND (burns[MeSH Terms] OR burns[All Fields] OR burn[All Fields] OR thermal trauma[All Fields]). For Ovid we used: exp Burns/ AND (exp Herpes Zoster/ or exp Encephalitis, Herpes Simplex/ or exp Herpes Simplex/ or exp Herpes Simples Virus Vaccines/), exp Burns/ AND (exp Cytomegalovirus/ or exp Cytomegalovirus Infections/), exp Burns/ AND (exp Chickenpox/ or Herpesvirus 3. Human/ or exp Herpes Zoster/). And for Web of Science we used: (TS=(HSV OR herpes OR CMV OR cytomegalovirus OR VZV OR varicella-zoster) AND TS=(burn OR burns OR thermal trauma)) AND LANGUAGE: (English) AND DOCUMENT TYPES: (Article); Timespan: All years; Indexes: SCI-EXPANDED, SSCI, A&HCI, CPCI-S.

Official Title
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Human Herpes Viruses in Burn Victims: A Systematic Review

Conditions
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Human Herpes Virus, Herpes Simplex Virus, Varicella-zoster Virus, Chickenpox, Cytomegalovirus, Burns

Intervention / Treatment
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* Other: Review of the Literature for Human Herpes Virus infections


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who presented with at least 1% TBSA burned Patients who presented with a viral infections during their hospitalization Exclusion Criteria: Patients who had no burns Patients who had no viral infections during their hospitalization
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Burn patients<br>The included patient are burn victims who sustained a burn of at least 1 % total body surface are (TBSA); with no restriction on age. | Other: Review of the Literature for Human Herpes Virus infections<br>* Review of the Medline database (PubMed and Ovid interface) for human herpes virus infections in burns as well as Web of Science interface. PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist were used.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of Human Herpes Virus (HHV) Infections | HHV include the herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr viruses (EBV) and human herpes virus 6 to 8 | Participants will be followed for the duration of hospital stay, an expected average of 3 months. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Treatment of Human Herpes Virus (HHV) Infections |  | Participants will be followed for the duration of hospital stay, an expected average of 3 months. |