linjc16/ctgov huggingface dataset:
Safety and Efficacy of Study Drug Versus Placebo for Negative Symptoms of Schizophrenia

Study Overview
=================
Brief Summary
-----------------
This study is to determine the efficacy (how well the drug works), safety, and side effects of the study medication compared to placebo in the treatment of the negative symptoms of schizophrenia in adults.

Conditions
-----------------
Schizophrenia

Intervention / Treatment
-----------------
* Drug: R209130


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion: Adults aged 18-60 Current diagnosis of schizophrenia Significant negative symptoms with few positive symptoms (e.g. hallucinations, delusions) and no evidence of major depression. Female subjects of childbearing potential must test negative for pregnancy at the time of enrollment. Subjects must be able to provide consent Must be healthy based on medical exam, laboratory tests and electrocardiogram Exclusion: Female subjects who are either pregnant or nursing. Acute or unstable medical conditions Diseases of the central nervous system Subjects who are judged clinically to be at serious risk for suicide or violence Subjects with delusional disorder, psychotic disorder NOS, schizophreniform, schizoaffective disorder, bipolar disorder, attention deficit/hyperactivity disorder, major depressive disorder,alcohol or drug dependence

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: R209130|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
schizophrenia with negative symptoms
A Qualitative Study of Delays in Hospital Admission in Patient With Acute Stroke

Study Overview
=================
Brief Summary
-----------------
To identify the circumstance during decision making processes to seek medical help in patients with symptoms of acute ischemic stroke.

Official Title
-----------------
Decision Making Process in Patients With Symptoms of Acute Ischemic Stroke Why do They Delay in Seeking Medical Help? A Qualitative Study

Conditions
-----------------
Acute Ischemic Stroke

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with confirmed acute ischemic stroke by brain image and were able to communicate in Mandarin or Taiwanese. Exclusion Criteria: patients who had cerebral hemorrhage, aphasia, cognitive dysfunction or severe stroke with unstable vital sign.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Qualitative study, stroke, 20 patients, Family or caregivers, acute ischemic stroke, delayed to receive thrombolytic therapy.
Assessment of Cognitive Functions in Bipolar Patients

Study Overview
=================
Brief Summary
-----------------
Assessment of cognitive function in manic bipolar patient

Detailed Description
-----------------
Assessment of severity of mania and depression in bipolar patients then evaluate their cognitive function.

Official Title
-----------------
Assessment of Cognitive Functions in Bipolar Disorder Patients

Conditions
-----------------
Bipolar Disorder

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Aged 18-55 years Of both sex Diagnosed as bipolar by DSM-5(patient) Exclusion Criteria: Current medical and psychiatric comorbidities which may affect cognitive status. Substance abuse or dependence (except nicotine and caffeine)in last month. Somatic treatment with drugs known to affect cognitive status (cortisol, antihistamines, etc.)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Biplar patients<br>diagnosed by DSM-5 and divided to manic,depressed and mixed last episod | |
| controlled subject<br>not have any medical or psychatric problem affect cognition | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assessment of severity of mania in bbipolar patients | EVALUATE manic patients by Young Mania Rating Scale (YMRS) | 2019-2022 | 
| Assessment of severity of depression in bipoiar patients | Evaluate depressed patients by Hamilton Rating Scale for depression(HRS). | 2019-2022 | 
| Assessment of cognitive function in bipoiar patients | Evaluate cognition in included patients by Montreal Cognitive Assessment(MOCA) and P300. | 2019-2022 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between cognitive state in bipolar patient and(onset age,illness duration and number of episodes). | from history | 2019-2021 |
European Sepsis Care Survey

Study Overview
=================
Brief Summary
-----------------
The objective of this survey is to investigate the current state of sepsis care around Europe. The study is aiming at hospital structure, emergency departments, wards, intensive care units and clinical diagnostic and microbiological service.

Official Title
-----------------
European Sepsis Care Survey

Conditions
-----------------
Sepsis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Hospitals of all strata Exclusion Criteria: -
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Questionnaire | Structure of sepsis care in Europe | 2021 |
Bowel Preparation and Pelvic Organ Prolapse Surgery

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to find out if performing a bowel preparation prior to pelvic organ prolapse surgery has any effect on the return of bowel function after surgery.

Official Title
-----------------
Bowel Preparation and Return of Bowel Function After Pelvic Organ Prolapse Surgery.

Conditions
-----------------
Pelvic Organ Prolapse

Intervention / Treatment
-----------------
* Other: Bowel preparation (Fleets enema)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Are between the ages of 21-90 years. Have a posterior vaginal wall prolapse. Are undergoing vaginal prolapse reconstructive surgery including posterior repair with suspension of the vaginal apex (top) to the ligaments in your pelvis, repair of the cul de sac or enterocele, with or without anti-incontinence surgery. Are receiving general anesthesia. Exclusion Criteria: Patient undergoing concomitant anal sphincteroplasty, rectovaginal fistula repair, rectopexy, or rectal resection/reanastomosis. Patient undergoing any mesh augmentation. Patient with any neurological condition involving bowel function. Patient on regular narcotic medication preoperatively. Patient does not want to be in the group she was randomized to. Patient currently pregnant or planning to become pregnant, or breastfeeding. Patient with ascites. Patient with known or suspected gastrointestinal obstruction or perforation. Patient with history of hyperparathyroidism. Patient with dehydration. Patient with active inflammatory bowel disease. Patients with congestive heart failure. Patients with dialysis dependent renal disease.

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Bowel preparation group<br>Patients randomized to this arm will perform a bowel preparation prior to their pelvic organ prolapse surgery. | Other: Bowel preparation (Fleets enema)<br>* Use of Bowel preparation (Fleets enema)<br>|
| No Intervention: No Bowel preparation group<br>Patients randomized to this group will not be performing a bowel preparation prior to their pelvic organ prolapse surgery. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measure the return of bowel function after pelvic organ prolapse surgery. |  | 10 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pelvic organ prolapse, Bowel preparation
Antibiotic-associated Coagulopathy

Study Overview
=================
Brief Summary
-----------------
Over the past few decades, a good number of studies with regard to coagulopathy and increased bleeding tendency which is defined as macro- or microscopic hemorrhage, declination of hemoglobin level, thrombocytopenia, and hypoprothrombinemia potentially caused by the use of antibiotics through a variety of suggested mechanisms, including myelosuppression, immune-mediated destruction of thrombocytes and coagulation factors, and suppression of vitamin K epoxide reductase or vitamin K-dependent γ-glutamate carboxylase which may lead to inhibition of biosynthesis of coagulation factor II, VII, IX, and X, have been reported or published. Nevertheless, many of them are case-series studies or case reports with low level of evidence, and there have been no large-scale retrospective cohort studies regarding antibiotic-associated coagulopathy being published. Moreover, in addition to exposure to antibiotics, there are several risk factors, including severity of illness, hepatic or renal function, nutrition status, comorbidities such as cancer and hematologic disease, surgery or other invasive procedure, concomitant use of anticoagulants, NSAIDs, and salicylates, and age, which may exert influence on the function of the coagulation system as well. Therefore, the study aims to clarify the association between the use of antibiotics and the increase of bleeding tendency or the development of bleeding event and to identify possible risk factors of the increase of bleeding tendency or the development of bleeding event in patients receiving antibiotic treatment through the application of nested case-control design and the usage of both the National Health Insurance Research Database (NHIRD) and medical records in National Taiwan University Hospital during the time period from January, 1995 to December, 2013.

Official Title
-----------------
Antibiotic-associated Coagulopathy

Conditions
-----------------
Infection, Blood Coagulation Disorders

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients aged older than 20 years old using antibiotics for more than 48 hours in the emergency department Exclusion Criteria: shift of antibiotic prescription in the ER patients with hemorrhage -related diagnoses non-temporally consecutive referral from the ER to the ward

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| development of any bleeding episodes as confirmed by ICD-9-CM code or use of vit. K1, fresh frozen plasma, or coagulation factors II, VII, XI, X |  | within 7 days post antibiotics use |
Improving Medication Adherence in Comorbid Conditions

Study Overview
=================
Brief Summary
-----------------
This study is designed to study how adults with Type 2 Diabetes and either high blood pressure and/or high blood cholesterol manage their treatment regimen. It is also called the Diabetes Management Study. Individuals need to be 40 years of age or older and on oral medication (pills) management for two of the three conditions of interest. They may also be on other treatment such as insulin, diet and/or exercise programs. Individuals will be followed for approximately 12 months. About 1/4 of the persons in the study will receive a telephone counseling program with a nurse focused upon their management of their treatment program.

Conditions
-----------------
Diabetes Mellitus, Type 2, Hypertension, Hyperlipidemia

Intervention / Treatment
-----------------
* Behavioral: telephone counseling


Participation Criteria
=================
Eligibility Criteria
-----------------
Type 2 diabetes mellitus, hypertension and/or hyperlipidemia, On oral medication for two of the above conditions, Manage own medications, Must have access to a telephone, Not participating in other adherence education or counseling trials

Ages Eligible for Study
-----------------
Minimum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: telephone counseling|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Diabetes
A Study Comparing Radiofrequency Ablation and Hepatic Resection for Hepatocellular Carcinoma

Study Overview
=================
Brief Summary
-----------------
The purpose of this prospective randomized study is to compare the efficacy and safety of radiofrequency ablation and hepatic resection for small hepatocellular carcinomas with very homogeneous underlying conditions.

Official Title
-----------------
A Prospective Randomized Study to Compare the Efficacy of Radiofrequency Ablation and Hepatic Resection as a Primary Treatment for Single Small Hepatocellular Carcinoma

Conditions
-----------------
Carcinoma, Hepatocellular

Intervention / Treatment
-----------------
* Procedure: Hepatic resection
* Procedure: Radiofrequency ablation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age between 20 and 70 years Child-Pugh class A (score 5-6) Single hepatocellular carcinoma Maximal diameter of the tumor from 2 to 4 cm when measured on MRI or CT (The diameter on MRI was measured prior to that on CT) No previous treatment Platelet count > 80,000/mm3 Exclusion Criteria: HCC abutting main hepatic veins or the first branches of the main portal vein HCC abutting vessels ≥ 0.5 cm

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Hepatic resection<br>Hepatic resection is performed as a primary treatment for hepatocellular carcinoma. | Procedure: Hepatic resection<br>* Anatomical surgical resection of the liver including the tumor<br>|
| Experimental: Radiofrequency ablation<br>Radiofrequency ablation is performed as a primary treatment for hepatocellular carcinoma. | Procedure: Radiofrequency ablation<br>* Percutaneous ablation using radiofrequency under the imaging guidance<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The patient survival |  | From the intervention up to 5 years or until the death of the participant whichever came first | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The disease-free survival |  | From the intervention up to 5 years or until hepatocellular carcinoma recurrence whichever came first |
Biomarkers for Human Heart Failure

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to establish the various ranges of proteins that can be assayed in the plasma and urine from hospitalized patients with all classes of heart failure and/or STEMI (ST-segment elevation myocardial infarction)/NSTEMI (Non-ST-segment elevation myocardial infarction), as well as history reviews.

Detailed Description
-----------------
Schematic Design of the Study: Single blood draw, one random urine and 24-hr urine collection from hospitalized patients with chronic/acute heart failure and/or STEMI-NSTEMI. If there should be a subsequent hospitalization,another collection of a 45 ml blood sample, random urine and one 24-hour urine collection may be completed if indicated at initial hospitalization. Aims: The purpose of this study is to attempt to establish the various ranges of proteins that can be assayed from the plasma and urine of patients with all classes of heart failure and MI (myocardial infarction). Follow-up hospitalizations may result in another 45 ml blood draw, random urine and 24-hr. urine collection to evaluate the outcome of the heart failure treatment used with the previous hospitalization, if indicated in consent. A history review will be necessary as well.

Official Title
-----------------
Biomarkers for Human Heart Failure

Conditions
-----------------
CHF

Intervention / Treatment
-----------------
* Other: sample analysis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: • Diagnosis of Acute decompensated heart failure Exclusion Criteria: • Hemoglobin less than 10, active cancer, or amyloidosis Patient with dialysis

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: sample analysis|blood, Random urine sample and 24-hour urine samples|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| uAGT levels in high-risk chronic HF patients | This study will provide new knowledge of the pathology and outcomes predicted by the use of uAGT in symptomatic chronic HF patients at high risk for future hospitalization and death. | 10 years | 
| Natriuretic peptide levels in ADHF patients | new knowledge of pathology and outcomes in ADHF patients | 20 years |
Visual Rehabilitation of Patients With Myopic Maculopathy

Study Overview
=================
Brief Summary
-----------------
The Visual Pathfinder (LACE inc.) offers a non- invasive, patient- centered visual rehabilitation system based on an acoustic biofeedback. The investigators wanted to evaluate its usefulness in the improvement of visual function in visually impaired patients with high myopia.

Conditions
-----------------
Myopic Maculopathy

Intervention / Treatment
-----------------
* Behavioral: biofeedback training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: high myopia (range 9-15 D) visited at the Outpatient Medical Retina's Hospital A. Fiorini Terracina (LT), University of Rome La Sapienza, Polo Pontino. The diagnosis of myopic maculopathy was made on the basis of a comprehensive ophthalmological evaluation which included: biomicroscopic examination of anterior and posterior segment, fluorescein angiography (FAG) (Heidelberg HRA-2, FA module Heidelberg, Germany), optical coherence tomography (OCT), Spectral Domain (Heidelberg HRA-2, OCT module Heidelberg, Germany) and microperimetry with microperimeter MP-1 (Nidek Technologies, Padova, Italy). Exclusion Criteria: The investigators have excluded patients with other eye diseases (glaucoma, AMD, retinal detachment, etc.), uncooperative patients and persons with opacity of the dioptric media.

Ages Eligible for Study
-----------------
Minimum Age: 35 Years
Maximum Age: 57 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: biofeedback<br> | Behavioral: biofeedback training<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| improvement of visual performance |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| improvement of visual acuity, retinal sensitivity, fixation stability |  |  |