SARS-CoV-2 Associated Respiratory Failure Recovery (COVID-19 CAir)

Study Overview
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Brief Summary
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the current pandemic of coronavirus disease (COVID-19) that can lead to respiratory failure requiring oxygen therapy. Some patients develop acute respiratory distress syndrome (ARDS) and may die despite intensive care therapy. Currently it is unknown a) how fast patients recover after being discharged from hospital and b) what underlying predictors may influence recovery.

Detailed Description
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Study aims: To evaluate subjective and objective recovery after discharge from hospital in patients with respiratory failure due to COVID-19. To identify risk factors for COVID-19 associated respiratory failure and prolonged recovery

Official Title
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Recovery in Patients With SARS-CoV-2 Associated Respiratory Failure

Conditions
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SARS-CoV 2, COVID

Intervention / Treatment
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* Other: Questionnaires, spirometry


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: hospitalization at University Hospital Zurich due to COVID-19 infection hospital discharge max. 4 weeks ago requiring supplemental oxygen Exclusion Criteria: <18 years non-German speaking no smartphone access

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| SARS-CoV-2 associated respiratory failure<br>Participants will receive a daily HrQoL questionnaire on their personal smartphone using the docdok health application during 3 months. A selection of participants will furthermore receive a custom-built home disease monitoring device during 1 month. Both procedures start at least 4 weeks after hospital discharge. | Other: Questionnaires, spirometry<br>* Questionnaires targeting health-related quality-of-life, symptoms, anxiety and depression<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Health-related quality-of-life | European Quality of Life - 5 Dimensions - 5 Levels Instrument (EQ-5D-5L). Scoring: Index ranges from 1 to <0, with lower scores indicating more limitations. | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anxiety and depression | Hospital Axiety and Depression Score (HADS). Scoring: Scores range from 0 to 42, with higher scores indicating more anxiety or depression symptoms. | 3 months | 
| Symptom burden | COPD Assessment Test (CAT). Scoring: Scores range from 0-40, with higher scores indicating more symptoms due to respiratory limitations. | 3 months | 
| Spirometry | Forced expiratory volume in one second (FEV1) in liters and percent predicted. | 1 month | 
| Spirometry | Forced vital capacity (FVC) in liters and percent predicted. | 1 month |