Impact of HPV Vaccination to Catch up in the Emergence of Lesions of the Cervix

Study Overview
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Brief Summary
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In France, the vaccination coverage observed for HPV vaccination is low for a full-scale regimen, and has been falling since 2010. A high rate of HPV vaccination coverage has a significant epidemiological impact with a reduction in cervical cancer mortality. There is less data on vaccinated catch-up patients. In 2017, these patients are 25 years of age or older and carry out screening smears. The aim of this study is to demonstrate whether HPV catch-up vaccination results in a decrease in the abnormal smear rate compared to the rate in unvaccinated patients. If so, these data will help mobilize doctors to vaccinate patients against HPV, even in catching-up.

Detailed Description
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In France, the observed vaccination coverage is very low for a complete regimen and has been declining since 2010. This low coverage makes it impossible to benefit from the efficiency observed in the other countries. Indeed, a high HPV vaccination coverage rate would allow an epidemiologically significant impact with a reduction in cervical cancer mortality. In France, it is estimated that the vaccination of 80% of girls between the ages of 11 and 14 would reduce the incidence of 72% of CIN2 and 54% of CIN3. Nevertheless, there is less data on patients who have been vaccinated in catch-up. These patients are 25 years of age or older in 2017, and make smears. The aim of this study is to demonstrate whether HPV catch-up vaccination results in a decrease in the abnormal smear rate compared to the rate in unvaccinated patients. If our study shows the benefits of catch-up vaccination, these data will help to mobilize doctors to vaccinate girls 15-19 years of age against HPV if they have not been able to benefit between 11 and 14 years as recommended.

Official Title
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Malvacdecision.Net

Conditions
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HPV Vaccination, Pap Smear, Cervical Cancer, Catch-up Vaccination

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: women aged 25 to 33 in 2017 with a smear analyzed at the Brest University Hospital Exclusion Criteria: men age over 33 years or less than 25 years patient refusing to participate

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 33 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Women aged 25 to 33 years in 2017<br>Women aged 25 to 33 years in 2017 and having performed an analyzed smear at the Brest University Hospital. They are invited to fill out an online questionnaire asking them about : vaccine status against HPV if vaccinated, the name of the vaccine and the number of injection age of first sexual intercourse do they have a gynecological pathology | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nature of smear: normal or not (including ASCUS and AGC) according to their immunization status |  | Day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| age of occurrence of lesions according to the year of vaccination |  | Day 1 (questionnaire completed by patient) | 
| number of injection received |  | Day 1 (questionnaire completed by patient) | 
| Age of onset of sexual activity |  | Day 1 (questionnaire completed by patient) | 
| Vaccine received |  | Day 1 (questionnaire completed by patient) |