Acute Effects of Whole-body Vibration Training in Hypoxia and Normoxia in Multiple Sclerosis Patients

Study Overview
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Brief Summary
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Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Moderate intensity strength training has been shown to improve strength and mobility in persons with MS. It was suggested that whole-body vibration training (WBVT) is effective to improve muscle strength, such as resistance training, resulting from both neural and structural adaptations. On the other hand, traditional strength training in hypoxia has garnered much attention. This method has shown improvements in isometric strength and increases in muscle size.

Detailed Description
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Crossover. 13 patients with multiple sclerosis were recruited. Patients performed two sessions: whole-body vibration training in normoxia condition and whole-body vibration in hypoxia condition.

Official Title
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Acute Effects of Whole-body Vibration Training in Hypoxia and Normoxia Condition on Neuromuscular Performance and Mobility in Patients With Multiple Sclerosis

Conditions
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Multiple Sclerosis

Intervention / Treatment
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* Other: Exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: mild or moderate disability with clinical mild spastic-ataxic gait disorder. stable phase of the disease. Exclusion Criteria: Expanded Disability Status Scale (EDSS) < 6. relapsing disease within the preceding 12 months. corticosteroid treatment within the last months before study inclusion.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Whole-body vibration in normoxia condition<br>Training session in normoxia condition | Other: Exercise<br>* Whole-body vibration training in hypoxia and normoxia condition<br>|
| Experimental: Whole-body vibration in hypoxia condition<br>Training session in hypoxia condition | Other: Exercise<br>* Whole-body vibration training in hypoxia and normoxia condition<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximal Voluntary Isometric Contraction of Knee Extension |  | Immediately before the training sessions | 
| Maximal Voluntary Isometric Contraction of Knee Extension |  | Immediately after the training sessions | 
| Rate of Force Development |  | Immediately before the training sessions | 
| Rate of Force Development |  | Immediately after the training sessions | 
| Central Activation Ratio |  | Immediately before the training sessions | 
| Central Activation Ratio |  | Immediately after the training sessions | 
| Biomechanical study of the walk by video recording | Kinematic analysis of knee and ankle angles during walking | Immediately before the training sessions | 
| Biomechanical study of the walk by video recording | Kinematic analysis of knee and ankle angles during walking | Immediately after the training sessions | 
| Biomechanical study of the walk by video recording | Stride amplitude during walking | Immediately before the training sessions | 
| Biomechanical study of the walk by video recording | Stride amplitude during walking | Immediately after the training sessions | 
| Spasticity | Pendulum test | Immediately before the training sessions | 
| Spasticity | Pendulum test | Immediately after the training sessions | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of Perceived Exertion | RPE Scale 6-20 | Immediately before the training sessions | 
| Rate of Perceived Exertion | RPE Scale 6-20 | Immediately after the training sessions | 
| Walking speed | Test 10 m-walks | Immediately before the training sessions | 
| Walking speed | Test 10 m-walks | Immediately after the training sessions | 
| Static balance | Romberg Test with eyes open and closed. Analysis with force plates | Immediately before the training sessions | 
| Static balance | Romberg Test with eyes open and closed. Analysis with force plates | Immediately after the training sessions | 
| Muscle oxygenation in soleus | MOXY's | Immediately before the training sessions | 
| Muscle oxygenation in soleus | MOXY's | Immediately after the training sessions | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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neuromuscular disease, whole-body vibration, hypoxia, strength