Effect of Glucose 5% on Labor Length

Study Overview
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Brief Summary
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Induction of labor, is one of the most common obstetric procedures done routinely in modern obstetrics. For example, in USA, 23% of pregnant women in 2012 (about 1 million) underwent an induction of labor. However, accurate data about percentage of women undergoing induction of labor in Egypt is not accurately known. One of the recent research era in current obstetrics is the optimal intravenous (IV) hydration of the pregnant women in labor.Current evidences available in our hands, suggest that maternal hydration appears to fasten labor progress and enhance the action of oxytocin, if the later is used for augmentation. However, the addition of glucose supplementation to this IV hydration to enhance uterine contraction, as a matter of safety and efficacy, is controversial

Official Title
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The Effect of Adding Parenteral Dextrose Solution During Induction of Labor on Total Labor Length Among Multiparous Women in Ismailia, Egypt: A Randomized Controlled Trial

Conditions
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Induction of Labor Affected Fetus / Newborn

Intervention / Treatment
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* Drug: Dextrose 5%/Nacl 0.3% Inj_#3
* Drug: Saline


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult (>18 years) multiparous women Late Term Pregnancy ( gestational Age Between 40-42 weeks) Uncomplicated singleton pregnancy with cephalic presentation. Favorable cervix for induction (Bishop score<6) without ruptured membranes. Exclusion Criteria: Women with chronic diseases or complicated pregnancy; gestational and pre gestational ( type 1 & 2)diabetes, preeclampsia and\or renal and\or maternal heart diseases. Non-cephalic presentations, multiple pregnancies, or cervix unfavorable for induction. Other indications for cesarean delivery

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: study group<br>women who will receive 250 mL/hour of dextrose 5% with normal saline in a 1:1 ratio. | Drug: Dextrose 5%/Nacl 0.3% Inj_#3<br>* 250 mL/hour of dextrose 5% intravenous drip<br>Drug: Saline<br>* 250 mL/hour of normal saline intravenous drip<br>|
| Active Comparator: control group<br>women who will receive 250 mL/hour of normal saline for the whole duration of induction | Drug: Saline<br>* 250 mL/hour of normal saline intravenous drip<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the duration of labor | the duration from the beginning of active labor (cervical exam between 3 and 5 cm with regular uterine contractions) to fetal delivery, reported in minutes. | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of cesarean sections | the number of cases delivered by cesarean section | 24 hours |