Treatment of Clozapine-Induced Hypersalivation Ipratropium Bromide

Study Overview
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Brief Summary
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Hypersalivation (Too much saliva) and drooling is a side effect experienced by 31% of people taking the antipsychotic clozapine. This study aims to determine if using the medication ipratropium bromide(IPB)at bedtime will reduce the amount of salivation and the distress people may feel.

Detailed Description
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With the recent questions regarding the effectiveness of newer atypical antipsychotic medications in treating schizophrenia, clozapine continues to remain the gold standard for treatment-refractory schizophrenia. However, treatment with clozapine continues to be limited by its many side effects. The second most common side effect, occurring in 31% of clozapine treated patients, is hypersalivation or sialorrhea. Sialorrhea can be profoundly stigmatizing and functionally disabling in certain patients, and may increase discontinuation rates in this high-risk patient population. Several studies have evaluated the efficacy of anticholinergic agents mainly in small, uncontrolled studies or anecdotal reports and are often complicated by difficulties in medication administration and systemic side effects. Open label and case series studies have demonstrated promising results with ipratropium bromide (IPB) treatment of clozapine-induced hypersalivation, acting on anticholinergic receptors with minimal systemic absorption. However, no randomized controlled trials have evaluated IPB in the treatment of this problematic side effect.The primary goals of this study is to determine the efficacy of ipratropium bromide in reducing clozapine-induced hypersalivation, as per the Toronto Nocturnal Hypersalivation Scale, which is a modified hypersalivation scale incorporating the Drooling Severity Scale and the Nocturnal Hypersalivation Rating Scale, and reduced measurements on visual analogue scales for hypersalivation distress and severity. Our hypothesis that Ipratropium bromide use at bedtime will result in a significant reduction in nocturnal clozapine-induced hypersalivation as measured by the Toronto Nocturnal Hypersalivation Scale (TNHS) through its local anticholinergic activity.

Official Title
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Treatment of Clozapine-Induced Hypersalivation Ipratropium Bromide

Conditions
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Hypersalivation

Intervention / Treatment
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* Drug: ipratropium bromide 0.03% spray


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis of schizophrenia or schizoaffective disorder as per DSM IV-TR criteria Receiving clozapine for at least 2 months No change in their clozapine dose for at least 2 weeks Have a Clinical Global Impression scale score for hypersalivation of greater than or equal to 4 Have the capacity to provide voluntary, informed consent Able to speak English Have a minimum score of 2 on the TNHS prior to study entry No change in medications for at least 2 weeks Exclusion Criteria: Subjects with co-morbid medical conditions that could influence hypersalivation (e.g. Idiopathic Parkinson's Disease) Subjects currently receiving ipratropium bromide for the treatment of hypersalivation or other medical conditions History of narrow-angle glaucoma, prostatic hyperplasia or bladder neck obstruction History of an allergic reaction to ipratropium bromide

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: A<br>Random assignment to investigational spray | Drug: ipratropium bromide 0.03% spray<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Toronto Nocturnal Hypersalivation Scale scores |  | intermittent | 
| Visual Analogue Scale - Severity |  | intermittent | 
| Visual Analogue Scale - Distress |  | Intermittent | 
| Simpson-Angus Rating Scale |  | Each study visit | 
| Clinical Global Improvement Scale |  | Each study visit | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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clozapine-induced hypersalivation