Periodontal Treatment With Diode Laser in the Patients With Diabetes Melitus

Study Overview
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Brief Summary
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This study aimed to investigate the effects of diode laser (DL) in addition to non-surgical periodontal treatment on periodontal parameters, systemic inflammatory response, and serum hemoglobin A1c (HbA1c) level in patients with uncontrolled type 2 diabetes mellitus (T2DM) and chronic periodontitis.

Detailed Description
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This study was designed as a randomized, controlled, full-mouth, 6-month clinical trial. 37 patients (20 women and 17 men) with uncontrolled T2DM and chronic periodontitis who were selected from among those admitting to Dentistry Faculty of Inonu University and Turgut Ozal Medical Center completed this study. The patients were divided into two groups. The individuals in the control group underwent placebo laser treatment in addition to scaling and root planing (SRP). The individuals in the study group underwent DL (1 W power) in addition to SRP. Clinical index measurements were performed before treatment (T0), 3 months after treatment (T1), and 6 months after treatment (T2). Plaque index (PI), gingival index (GI), bleeding on probing (BOP), clinical attachment level (CAL), and probing depth (PD) were measured to determine periodontal status. HbA1c and C-reactive protein (CRP) levels were also analyzed using blood samples.

Official Title
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Evaluation of Long-Term Effects of Diode Laser Application on Periodontal Healing, Serum C-Reactive Protein and HbA1c Levels in Periodontal Treatment of Uncontrolled Type-2 Diabetic Subjects With Chronic Periodontitis

Conditions
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Diabetes Mellitus, Periodontal Disease

Intervention / Treatment
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* Device: Laser group
* Device: Control group


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Having a diagnosis of type-2 DM according to the ADA criteria for at least two years before the study, HbA1c⩾7%,28 Having no change in antidiabetic drugs in the last 3 months, Having no major diabetes complications (because chronic complications of diabetes complicate metabolic control), Presence of generalized CP,29 Presence of an area with a pocket depth of 4-7 mm in at least four teeth in the upper jaw, Presence of at least 20 teeth in the mouth, Having no any systemic illness except for DM, Having no smoke, Receiving no periodontal treatment in the last 12 months, Receiving no antibiotics or anti-inflammatory drugs for a long period in the last 6 months, Not being pregnant or not to breastfeed, Having no third molars. Exclusion Criteria: -
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: This study was designed as a randomized, controlled.
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Study group<br>SRP plus diode laser (810 nm wavelength, 1 W power) | Device: Laser group<br>* Laser application in addition to SRP<br>* Other names: Gigaa Laser;|
| Active Comparator: Control group<br>SRP plus placebo | Device: Control group<br>* Placebo laser application in addition to SRP<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Laboratory findings | Serum HbA1c levels were measured using the high-performance liquid chromatography method. | Six months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical findings | Probing depth (PD) was measured the distance between the gingival margin and the deepest aspect of the pocket (mm). | Six months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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glycemic control, laser, periodontal treatment, systemic inflammation