Does Mixing Alcoholic Drinks Make Hangover Worse?

Study Overview
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Brief Summary
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Does mixing alcohol make hangover worse?

Detailed Description
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Hangover is the most commonly occurring morbidity associated with heavy drinking. Our aim was to test the hypothesis that mixing alcoholic drinks as compared to drinking one type of alcohol only (beer, wine or spirits) associate with a higher alcohol intake and worse hangover.

Official Title
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Does Mixing Alcoholic Drinks Make Hangover Worse? A Randomized Controlled Trial in a Naturalistic Setting

Conditions
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Alcohol-Related Disorders

Intervention / Treatment
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* Dietary Supplement: Mixing alcohol
* Dietary Supplement: Single type alcohol


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: written and oral consent minimum 18 years old participating in Danish Health Research Retreat in Turkey 2016 will consume alcoholic beverages Exclusion Criteria: underage will not consume alcoholic beverages

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: single type<br>Restricted to drinking only one type of alcohol | Dietary Supplement: Single type alcohol<br>* Alcoholic beverages, different types<br>* Other names: Ethanol;|
| Active Comparator: mixed type<br>Drinking and mixing different types of alcohols freely | Dietary Supplement: Mixing alcohol<br>* Alcoholic beverages, different types<br>* Other names: Ethanol;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acute Hangover Severity Scale (AHSS) | AHSS is a 12-item alcohol hangover measurement tool recommended for application in hangover research with a predictive validity of 92.4 %, significantly higher than that of other hangover scales (Penning et al., 2012). Alcohol hangover was measured thrice the day after drinking; in the morning immediately after waking up, at midday, and in the afternoon. The individual participant assessed his or her own hangover the day after. | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of drinks | Total number of drinks defined as 12 g of alcohol consumed during evening | Baseline | 
| Acute Hangover Severity Scale (AHSS) 2 | AHSS is a 12-item alcohol hangover measurement tool recommended for application in hangover research with a predictive validity of 92.4 %, significantly higher than that of other hangover scales (Penning et al., 2012). Alcohol hangover was measured thrice the day after drinking; in the morning immediately after waking up, at midday, and in the afternoon. The individual participant assessed his or her own hangover the day after. | after 4 hours | 
| Acute Hangover Severity Scale (AHSS) 3 | AHSS is a 12-item alcohol hangover measurement tool recommended for application in hangover research with a predictive validity of 92.4 %, significantly higher than that of other hangover scales (Penning et al., 2012). Alcohol hangover was measured thrice the day after drinking; in the morning immediately after waking up, at midday, and in the afternoon. The individual participant assessed his or her own hangover the day after. | after 8 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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alcohol, hangover