Study Comparing Two Types of Psychotherapy for Treating Depression and Substance Abuse

Study Overview
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Brief Summary
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The purpose of this study is to determine whether Integrated Cognitive Behavioral Therapy or Twelve Step Facilitation Therapy is most effective for treatment of dually diagnosed veterans with depressive and substance use disorders.

Detailed Description
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Depression is the most frequent co-occuring mental health disorder among adults with substance use disorders, and such comorbidity is often associated with poorer treatment outcomes. Although there is an urgent need for effective treatments specific for dual-diagnosis adults, few studies have been conducted to address this need. Comparison: This study will compare substance use and depression symptoms of individuals in two different psychotherapy groups: Integrated Cognitive Behavioral Therapy and Twelve Step Facilitation Therapy. Symptoms and substance use will be compared during the active treatment phase (24 weeks) and for one year following the end of the active treatment.

Official Title
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Integrated CBT for Substance Use and Depressive Disorders

Conditions
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Alcohol Abuse, Cannabis Abuse, Major Depressive Disorder, Substance-Related Disorders

Intervention / Treatment
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* Behavioral: Integrated Cognitive Behavioral Therapy
* Behavioral: Twelve Step Facilitation Therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Individuals diagnosed with one or more substance use disorders (alcohol, cannabis, and or stimulant abuse/dependence) and an independent co-occurring depressive disorder (major depression or dysthymia) will be included. Exclusion Criteria: Individuals with substance induced mood disorders and individuals experiencing persistent psychotic symptoms. Those with life threatening or unstable medical illness, neurological disorders, or inability to read will be excluded. Individuals currently prescribed steroids, disulfiram, or long acting benzodiazepines will be excluded.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Integrated Cognitive Behavioral Therapy | Behavioral: Integrated Cognitive Behavioral Therapy<br> <br> |
| Experimental: 2<br>Twelve Step Facilitation Therapy | Behavioral: Twelve Step Facilitation Therapy<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Alcohol Abuse/Dependence, Alcohol Use Disorders, Cannabis Abuse/Dependence, Depression, Dual diagnosis, Dysthymia, Stimulant Abuse/Dependence, Substance Use Disorders