linjc16/ctgov huggingface dataset:
Muscle Elastography in Spastic Cerebral Palsy

Study Overview
=================
Brief Summary
-----------------
To date, clinical tests are unable to differentiate between the cause of muscle stiffness, although a manual instrumented spasticity assessment for the lower limb that utilizes surface electromyogram has recently been proposed. This study intends to use shear wave elastography to assess individual muscle stiffness parameters and the individual response to botulinum toxin injection in the elbow and wrist flexors. Collection of baseline spasticity parameters could then be used to predict the effect of botulinum toxin type A and ultimately serve as a basis for development of a treatment model for muscle spasticity in patients with spastic cerebral palsy.

Official Title
-----------------
Use of Elastography to Quantify Change in Upper Extremity Muscle Spasticity Following Botox Injection in Children With Spastic Cerebral Palsy

Conditions
-----------------
Unilateral Spastic Cerebral Palsy

Intervention / Treatment
-----------------
* Drug: Botulinum toxin type A


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with unilateral spastic cerebral palsy with presence of dynamic muscle spasticity in the elbow and/or wrist flexors, who will be able to provide consent. Consent may be obtained from a parent or legal guardian, as applicable. Exclusion Criteria: Prior surgical procedure in the affected upper extremity Unrelated orthopedic injury to the affected upper extremity Current oral or intrathecal antispasticity therapy Prior Botulinum toxin type A injection in preceding 6 months

Ages Eligible for Study
-----------------
Minimum Age: 5 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Botulinum toxin type A|Botox injection in upper extremity for spasticity in pediatric CP patients|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle Elasticity | Change in muscle elasticity (in kilopascal ) | From immediate pre-injection to 1 month post-injection. | 
| Muscle Elasticity | Change in muscle elasticity (in m/s) | From immediate pre-injection to 1 month post-injection. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Functional measures | Functional measures (MAS) | immediately pre- and immediately post-injection, and at 1 month, 3 months and 6 months post-injection. | 
| Functional measures | Functional measures (PROM) | immediately pre- and immediately post-injection, and at 1 month, 3 months and 6 months post-injection. |
Oligosecretary Myeloma: Prevalence and Its Clinical Significance

Study Overview
=================
Brief Summary
-----------------
In this study, the investigators aim to investigate the prevalence and clinical course of oligosecretary myeloma.

Detailed Description
-----------------
Oligosecretary myeloma is a subgroup of multiple myeloma (MM) characterized by low levels of serum and urine monoclonal (M) protein below thresholds of measurable disease (a serum M protein ≥ 1g/dL, a urine M protein ≥ 200mg/day). Patients with oligosecretary myeloma do not have established methods for disease monitoring and clinical informations regarding oligosecretary myeloma are still largely unknown. In this study, we aimed to investigate the prevalence and clinical course of oligosecretary myeloma.

Official Title
-----------------
Oligosecretary Myeloma: Prevalence and Its Clinical Significance

Conditions
-----------------
Multiple Myeloma

Intervention / Treatment
-----------------
* Other: oligosecretary


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: a subgroup of multiple myeloma (MM) characterized by low levels of serum and urine monoclonal (M) protein below thresholds of measurable disease (a serum M protein ≥ 1g/dL, a urine M protein ≥ 200mg/day) available clinical data Exclusion Criteria: patients without available clinical data

Ages Eligible for Study
-----------------
Minimum Age: 17 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| oligosecretary<br>Multiple myeloma (MM) characterized by low levels of serum and urine monoclonal (M) protein below thresholds of measurable disease (a serum M protein ≥ 1g/dL, a urine M protein ≥ 200mg/day) | Other: oligosecretary<br>* not abvailable<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with oligosecretary myeloma among multiple myeloma patients |  | up to 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
oligosecretary multiple myeloma
Markers of Infection and Resistance in Invasive Fusariosis

Study Overview
=================
Brief Summary
-----------------
In recent decades, invasive fusarioses have been emerging fungal pathologies with high mortality. The prognosis depends on the speed of the diagnosis, but currently biological diagnosis is mainly based on fungal culture, no specific biomarker for this microorganism is available in current clinical practice. The genus Fusarium also shows reduced sensitivity to antifungals commonly used and recommended in clinical practice, such as voriconazole or amphotericin B. The main objective of this study is to describe the proportions of different fungal species in positive fungal cultures in patients with invasive fungal infection (IFI) or fungal keratitis. The secondary objectives are the description of the dosage of galactomannans, beta (1,3) -D-glucans and the rate of detection of DNA circulating in case / control groups for the 2 clinical forms studied. In patients with evidence of Fusarium wilt, the study will describe the distribution of the different minimum inhibitory concentrations (MIC) depending on whether or not different antifungals are taken, the vital status at 3 months, and the response or not to treatment. Finally, the presence of genetic markers will be described according to the groups of MIC values.

Official Title
-----------------
Multicenter Study on Invasive Fusariosis : Looking for Markers of Infection and Resistance

Conditions
-----------------
Fusariosis

Intervention / Treatment
-----------------
* Diagnostic Test: biomarkers


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Suspicion of invasive fungal infection involving the performance of a blood culture or a skin biopsy or diagnosis of keratitis involving the taking of a cornea sample Fungal culture carried out on this sample Person having been informed of the research and not having opposed the use of their data Exclusion Criteria: Clinical diagnosis of superficial fusarium wilt (onychomycosis, etc.)
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Invasive fusariosis<br> | Diagnostic Test: biomarkers<br>* galactomannan, betaDglucan, resistance markers<br>|
| Fusarium keratitis<br> | Diagnostic Test: biomarkers<br>* galactomannan, betaDglucan, resistance markers<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| proportions of different fungal species in positive fungal cultures in patients with invasive fungal infection (IFI) or fungal keratitis |  | 2021-2026 |
Support for Increased Physical Activity (Stöd Till Aktivare Motion)

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to improve and analyze the level of physical activity in immigrant women from the Middle East and Latin America living in Sweden. The investigators will also investigate if glucose, insulin, and lipid metabolism; stress-related hormone production; and subclinical inflammatory activity are affected by the intervention. The follow-up period is 2 years.

Official Title
-----------------
Intervention Program for Physically Inactive and Overweight Immigrant Women From the Middle East and Latin America Living in Sweden

Conditions
-----------------
Overweight

Intervention / Treatment
-----------------
* Behavioral: Support for Increased Physical Activity


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Female gender Age 25 through 64 years Physical inactivity BMI > 25 Immigrant to Sweden from either the Middle East or Latin America Exclusion Criteria: Diabetes mellitus type I Ischemic heart disease Disability that interferes with the ability to participate in lifestyle-related physical activity

Ages Eligible for Study
-----------------
Minimum Age: 25 Years
Maximum Age: 64 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: A<br>exercise referral to lifestyle activities at the level of moderate intensity without support | |
| Active Comparator: B<br>Exercise referral combined with individual support, access to structured group exercise programs, and motivational support | Behavioral: Support for Increased Physical Activity<br>* Exercise referral combined with individual support, access to structured group exercise programs, and motivational support<br>* Other names: Stöd Till Aktivare Motion;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The relative effectiveness of two physical activity programs in affecting glucose metabolism, lipid metabolism and stress-related hormone production |  | 2 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
overweight, physical inactivity, physical fitness, lifestyle change
Impact of New CLSI Guidelines on Antibiotic Susceptability Pattern

Study Overview
=================
Brief Summary
-----------------
Assessing the precise MIC for the Ceftriaxone using E-test. To determine what proportion of susceptibility reports will be reclassified based on the new CLSI guidelines.Antibiotic susceptibility reports of blood cultures, urine cultures,aseptic body fluid cultures growing Enterobacteriaceae organism generated by the Phoenix machine will be obtained on a daily basis.MIC for Ceftriaxone will be noted.If the MIC is <=2 for Ceftriaxone,those cultures would be used to run an additional test - E- test.E-test gives us more precise MIC values compared to Phoenix machine.We will analyze the data collected over 2 months. We will determine the proportion of susceptibility reports reclassified based on the new CLSI guidelines.

Official Title
-----------------
A STUDY ASSESSING THE IMPACT OF THE NEW CLSI GUIDELINES ON ANTIBIOTIC SUSCEPTABILITY TESTING PATTERNS

Conditions
-----------------
Antibiotic Susceptibility Patterns

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Antibiotic susceptibility reports of blood cultures, urine cultures,aseptic body fluid cultures growing Enterobacteriaceae organism generated by the Phoenix machine. Exclusion Criteria: none

Ages Eligible for Study
-----------------
Minimum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Effect of Cranberry Capsules on Urinary Infection Rates in Spinal Cord Injured Patients During Post Acute Rehabilitation

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to establish whether cranberry capsules reduce rates of urinary tract infections during initial rehabilitation immediately after spinal cord injury.

Official Title
-----------------
Evaluation of the Effect of Cranberry Capsules on the Occurrence of Urinary Tract Infections During Post-acute Rehabilitation of Spinal Cord Injured Patients

Conditions
-----------------
Spinal Cord Injury, Urinary Tract Infection, Rehabilitation

Intervention / Treatment
-----------------
* Dietary Supplement: Cranberry capsules


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Previously essentially healthy Newly acquired spinal cord injury, T12 level or higher Receiving in-patient care on the rehabilitation ward. Expected admission duration >= 4 weeks 16 years old or older Exclusion Criteria: Current or previous disorder that increases the risk of urinary tract infection including diabetes, urological disorder, previous operation on urinary tracts or kidneys, immune dysfunction Severe head injury with impairment of cognitive function Allergy to cranberry Renal failure Warfarin (Coumarin) treatment with unstable INR Current symptomatic urinary tract infection

Ages Eligible for Study
-----------------
Minimum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cranberry capsule<br> | Dietary Supplement: Cranberry capsules<br>* Cranberry capsules, 550mg, or placebo capsules, two capsules three times daily during in-patient rehabilitation<br>|
| Placebo Comparator: Placebo capsule<br> | Dietary Supplement: Cranberry capsules<br>* Cranberry capsules, 550mg, or placebo capsules, two capsules three times daily during in-patient rehabilitation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of symptomatic urinary tract infections per patient per month during in-patient post acute rehabilitation |  | At end of study | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of in-patient rehabilitation days on which patients were unable to participate in active rehabilitation due to urinary tract infection. |  | At end of Study | 
| Patient's experience of urinary symptoms in the absence of symptomatic urinary tract infection. |  | At end of study | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
urinary tract infection, prevention, rehabilitation, spinal cord injury
Impact of a Multidisciplinary Therapeutic Education Program Being Set up for Patients With Type 2 Diabetes Mellitus

Study Overview
=================
Brief Summary
-----------------
Therapeutic education programs allows in diabetic patients to promote self-care and better perception of the disease The multidisciplinary program of therapeutic education regroups in one day: individual interview, nutritional workshop, self-monitoring blood glucose workshop, physical activity and glycemic objectives workshop. At the end of the program, individual and personalized goals are given to the patient. This study aims to evaluate this program success rates and the psychological, anamnesis, and sociological factors linked to success.

Official Title
-----------------
Evaluation of a Multidisciplinary Program of Therapeutic Education in Type 2 Diabetes Mellitus Diabetes in Order to Fix Individualized Objectives

Conditions
-----------------
Diabetes Mellitus, Type 2, Patient Education as Topic

Intervention / Treatment
-----------------
* Other: Treatment adequacy score


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All Type 2 diabetic patients who participate in the multidisciplinary program Signature information form and consent by the patient Exclusion Criteria: None

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Treatment adequacy score|Evaluation of the program rate of success rate by a score evaluating the different criteria that the patient was supposed to modify following the therapeutic education program: practice of a physical activity, reduction of the amount of fat in Diet, practice of self-monitoring blood sugar as a motivational tool and decreased distress related to diabetes|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Success rate of the therapeutic education program | The rate of success of the program defined by a 50% improvement in the treatment adequacy score evaluated at 1 month | one month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Long term success rate of the therapeutic education program | The rate of success of the program defined by a 50% improvement in the treatment adequacy score evaluated at 6 month | 6 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Diabetes Mellitus, Type 2 +, Patient Education
Evaluation of Visual Outcomes After Myopic LASIK

Study Overview
=================
Brief Summary
-----------------
The aim of the study was to evaluate visual outcomes, contrast sensitivity, glare testing and high order aberrations induced by different laser technologies and to evaluate differences in aberrometer technology. We hypothesized that there will not be differences among conventional or wavefront guided treatments.

Detailed Description
-----------------
The aim of the study was to evaluate and compare visual outcomes, contrast sensitivity, glare testing and induction of high order aberrations by different laser technologies and to evaluate differences in aberrometer technology.

Official Title
-----------------
Analysis of Visual Outcomes, Contrast Sensitivity, Glare, Induction of High Order Aberrations and Wavefront Technology, Following LASIK Surgery

Conditions
-----------------
Myopia, Astigmatism, Myopic Astigmatism

Intervention / Treatment
-----------------
* Procedure: Conventional LASIK
* Procedure: Wavefront-guided LASIK


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years or older Candidates for bilateral LASIK Myopic range: 0.00 to -7.00 D Astigmatism: 0.00 to -5.00 D Exclusion Criteria: Pupil size greater than 8mm diameter, infrared measurement thin corneas (preoperatively calculated minimal residual bed < 250 um) irregular astigmatism asymmetric astigmatism unstable refraction other criteria that preclude the patient to undergo LASIK

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Conventional LASIK|nan|
|Procedure: Wavefront-guided LASIK|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual acuity |  |  | 
| Contrast sensitivity |  |  | 
| Induction of high order aberrations |  |  |
Effect of Carum Carvi on Thyroid Hormones and TSH Level

Study Overview
=================
Brief Summary
-----------------
Carum Carvi has been frequently used in traditional medicine for a variety of disease ranging from dyspepsia to Alzheimer's disease.We observed high TSH levels in few patients with thyroid cancer who receiving Carum Carvi despite being on suppressive dose of levothyroxin. TSH level returned to normal after discontinuation of the Carum carvi. This observation led to a pilot study for evaluation of the effect of carum carvi on thyroid function.

Official Title
-----------------
Evaluation of the Effect of Carum Carvi on Levels of Plasma Thyroid Hormones and TSH Level in Patients on Thyroid Hormone Therapy and Normal Controls.

Conditions
-----------------
Thyroid Cancer Patients

Intervention / Treatment
-----------------
* Drug: Carum Cravi
* Drug: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 18-65 Hypothyroid patients under treatment with levothyroxin Normal euthyroid patients with no goiter Exclusion Criteria: Pregnancy or lactation Severe lung or gasterointestinal disease Heart failure or renal failure

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group3<br>Normal controls | Drug: Carum Cravi<br>* 40mg/kg of body weight<br>|
| Placebo Comparator: Group4<br>Normal controls | Drug: Placebo<br>* Placebo<br>|
| Active Comparator: Group 1<br>Hypothyroid patients taking levothyroxin. | Drug: Carum Cravi<br>* 40mg/kg of body weight<br>|
| Placebo Comparator: Group2<br>Hypothyroid patients taking levothyroxin | Drug: Placebo<br>* Placebo<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of Thyroid and thyrotropin values from baseline at 2 and 6 weeks | TSH, Free T4, Free T3, T4RIA and T3RIA | 0-2-6 Weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of hypothyroidism index from baseline at 2 and 6 weeks | Hypothyroidism Index | 0,2 and 6 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
well differentiated thyroid cancer, Carum Carvi, Normal controls