A Study of MHE in Patients With Liver Diseases

Study Overview
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Brief Summary
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The investigators analyze the diagnostic efficacy of blood ammonia, neurophysiological/psychological tests and blood markers on MHE; to see the progression of HE under the condition of the drugs intervention and no drugs intervention in clinical real world.

Detailed Description
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In China, hepatic encephalopathy (HE) is a common complication and one of the most serious manifestations of liver disease, not only increasing the risks of death, but also seriously affecting the lives of the patients and their caregivers. CHE includes the 1st stage of HE and minimal encephalopathy (MHE). It has indicated in a study that the mortality rates of covert hepatic encephalopathy (CHE) and overt hepatic encephalopathy (OHE) were both high (21% and 21.8% respectively). At present, CHE, especially MHE, is not easy to diagnose in daily clinical work. This study aims to early diagnose MHE and find suitable treatment to benefit patients. The investigators analyze the diagnostic efficacy of blood ammonia, neurophysiological/psychological tests and blood markers on MHE; to see the progression of HE under the condition of the drugs intervention and no drugs intervention in clinical real world.

Official Title
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A Study on Early Diagnosis and Treatments of Minimal Hepatic Encephalopathy(MHE) in Patients With Liver Diseases

Conditions
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Hepatic Encephalopathy, Liver Diseases, Minimal Hepatic Encephalopathy, Cirrhosis, Liver, Acute-On-Chronic Liver Failure

Intervention / Treatment
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* Diagnostic Test: blood ammonia test, neurophysiological/psychological tests, blood markers.
* Drug: HE drug treatments in clinical real world


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: >18 years old cirrhosis acute on chronic liver failure severe liver diseases Exclusion Criteria: liver cancer other malignancy poor eyesight uncooperative

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| MHE group<br>Patients whose MHE test are positive | Diagnostic Test: blood ammonia test, neurophysiological/psychological tests, blood markers.<br>* Let the patients do neuropsychological/psychological tests and use blood test for ammonia and blood markers.<br>Drug: HE drug treatments in clinical real world<br>* record the HE drug treatments in clinical real world if doctors use them<br>|
| no HE group<br>Patients whose MHE test are negative | Diagnostic Test: blood ammonia test, neurophysiological/psychological tests, blood markers.<br>* Let the patients do neuropsychological/psychological tests and use blood test for ammonia and blood markers.<br>|
| overt HE group<br>2/3/4 HE patients | Diagnostic Test: blood ammonia test, neurophysiological/psychological tests, blood markers.<br>* Let the patients do neuropsychological/psychological tests and use blood test for ammonia and blood markers.<br>Drug: HE drug treatments in clinical real world<br>* record the HE drug treatments in clinical real world if doctors use them<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| progression of HE | Incidence of HE progression (none HE, 1 HE, 2/3/4 HE) | 1 year | 
| mortality at 90 days | mortality rate at 90 days | 90 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| liver disease progression | Incidence of liver disease progression (such as cirrhosis, decompensation of liver function, liver cancer, liver transplantation, or liver related death) | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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neurophysiological/psychological tests, blood ammonia, early Diagnosis, Minimal Hepatic Encephalopathy, Hepatic Encephalopathy, Liver Diseases, Cirrhosis, Liver, Acute-On-Chronic Liver Failure, early treatment