Bilateral Deficit Phenomenon in Patients With Haemophilic Arthropathy

Study Overview
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Brief Summary
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Trial to assess the bilateral deficit phenomenon during dynamic plantar flexion task in patients with haemophilic arthropathy Describe the differences in terms of the physical variables (muscular strength, range of motion and proprioception) in patients with hemophilia who have conducted a home treatment with a digital tool. Bookmark the relationship between clinical history of joint bleeds and clinical manifestations in standing and walking.

Detailed Description
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Assess the bilateral deficit phenomenon during dynamic plantar flexion task in patients with haemophilic arthropathy. Indicate the independent variables that influence the development of strength and contractile activity, with or without previous joint bleeds in haemophilia patients with minors. Observe the descriptive variables people influence the standing, the incorporation from sitting and jumping.

Official Title
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Assessment of Bilateral Deficit Phenomenon During Dynamic Plantar Flexion Task in Patients With Haemophilic Arthropathy

Conditions
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Hemophilia

Intervention / Treatment
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* Other: Patients with haemophilia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients diagnosed with hemophilia A and B. With or without joint involvement clinically diagnosed, and with or without a previous history of hemarthrosis joint load legs. In prophylactic regimen with FVIII / FIX concentrates . Residents in the Autonomous Community of the Region of Murcia. Exclusion Criteria: Patients without walking ability. Patients diagnosed with other congenital coagulopathy (von Willebrand disease, etc..). Patients with neurological or cognitive impairments that prevent understanding the questionnaires and physical tests. Patients whose parents or guardians have not signed the informed consent document.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with haemophilia<br>Assessment of bilateral deficit phenomenon during dynamic plantar flexion task | Other: Patients with haemophilia<br>* Assessment of bilateral deficit phenomenon during dynamic plantar flexion task with a force platform (Kistler 9286 BA model, Kistler Instruments, Amherst, NY, USA)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assessment of Bilateral Index of Maximal Peak Force | Assessment of bilateral index of maximal peak force with a force platform (Kistler 9286 BA model, Kistler Instruments, Amherst, NY, USA). | Screening visit | 
| Assessment of Bilateral Index of Rate of Development During the Preparation Phase | Assessment of Bilateral index of rate of development during the preparation phase with a force platform (Kistler 9286 BA model, Kistler Instruments, Amherst, NY, USA) | Screening visit | 
| Assessment of Bilateral Index of Rate of Development During the Acceleration Phase | Assessment of bilateral index of rate of development during the acceleration phase with a force platform (Kistler 9286 BA model, Kistler Instruments, Amherst, NY, USA) | Screening visit | 
| Assessment of Maximal Peak Force | Assessment of maximal peak force with a force platform (Kistler 9286 BA model, Kistler Instruments, Amherst, NY, USA) | Screening visit | 
| Assessment of Rate of Development During the Preparation Phase | Assessment of rate of development during the preparation phase with a force platform (Kistler 9286 BA model, Kistler Instruments, Amherst, NY, USA) | Screening visit | 
| Change of Joint Condition Based on Clinical Assessment | Spanish version of the Haemophilia Joint Health Score 2.1 (HJHS). Additive scale that assesses from 0 to 24 points joint status of patients with haemophilia (0: no joint damage; 24: maximum joint damage). The variables studied in this scale are: Swelling (range 0-3); Duration of swelling (range 0-1); Muscle atrophy (range 0-2); Crepitant in motion (range 0-2); Loss of Flexion (range 0-3); Loss of extension (range 0-3); Joint pain (range 0-2): Strength (range 0-4); Gait (range 0-4) | Screening visit | 
| Assessment of Rate of Development During the Acceleration Phase | Assessment of rate of development during the acceleration phase with a force platform (Kistler 9286 BA model, Kistler Instruments, Amherst, NY, USA) | Screening visit | 
| Assessment of Maximal Velocity of Movement | Assessment of maximal velocity of movement with a force platform (Kistler 9286 BA model, Kistler Instruments, Amherst, NY, USA) | Screening visit | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Weight of the Patients With Haemophilia | The weight were collected using a TANITA equipment (TBF-300WA model, Tanita Corporation of America, Inc., Illinois, USA) | Screening visit | 
| Diagnosis, Severity of Hemophilia, Treatment (Prophylactic or on Demand) | Patients fill out a registration key clinical data (type, severity of hemophilia, hemarthrosis in the previous month and current drug therapy). | Screening visit | 
| Joint Bleeding Before the Assessment |  | Screening visit | 
| Height of the Patients With Haemophilia | The height of patients was calculated using a TANITA equipment (TBF-300WA model, Tanita Corporation of America, Inc., Illinois, USA). | Screening visit | 
| Body Mass Index of Patients With Haemophilia | The body mass index of patients was calculated using a TANITA equipment (TBF-300WA model, Tanita Corporation of America, Inc., Illinois, USA). | Screening visit | 
| Age of Patients With Haemophilia |  | Screening visit | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Haemophilia, Arthropathy, Bilateral deficit phenomenon, Proprioception