Interest of MRI in Preoperative Staging for the Laryngeal and Hypopharyngeal Cancer

Study Overview
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Brief Summary
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To determine if MRI can detect preoperative invasion of cartilage by laryngeal and hypopharyngeal carcinoma, and to compare it to CT imaging and histopathology in excised larynges and/or hypopharynges.

Official Title
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Interest of MRI in Preoperative Staging for the Laryngeal and Hypopharyngeal Cancer

Conditions
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Hypopharyngeal Carcinoma, Laryngeal Carcinoma

Intervention / Treatment
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* Other: Pharyngo laryngeal MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient ≥18 years old Patient with a laryngeal or hypopharyngeal cancer at any stage Patient eligible for a surgical treatment in multidisciplinary consultation Patient who did not oppose its participation to the study Indication for performing an MRI in addition to CT at the discretion of the investigator Exclusion Criteria: Patient with an ASA (American Society of Anesthesiologists, international anesthesia classification) score ≥ 3, Patient with a chirurgical contraindication Patient with a MRI contraindication Pregnant or nursing woman Adult requiring protection (guardianship, supervision) Patient participating in interventional research (Excluding physiological studies and interventional research involving only minimal risks and constraints that do not interfere with the analysis of the primary outcome).

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pharyngo laryngeal MRI<br>Patient with a laryngeal or hypopharyngeal cancer at any stage, with a doubt about cartilage invasion and eligible for surgical treatment for which there is an indication for performing an MRI in addition to CT at the discretion of the investigator | Other: Pharyngo laryngeal MRI<br>* Patients will be outgoing a pharyngolaryngeal MRI, with injection of gadolinium, in addition to the CT imaging. They will have this MRI in case of doubt about cartilage invasion. It will be realised during the time between the CT imaging and the day of surgery. Device : gadolinium-based MRI contrast agent This will be realized according to the standard procedure.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Endoscopy | Tumor stage and cartilage invasion as determined by endoscopy : invaded/non invaded/undetermined | 1-4 weeks | 
| CT scan | Tumor stage and cartilage invasion as determined by CT scan : invaded/non invaded/undetermined | 1-4 weeks | 
| MRI | Tumor stage and cartilage invasion as determined by MRI : invaded/non invaded/undetermined | 1-4 weeks | 
| Anatomopathological analysis | Tumor stage and cartilage invasion as determined by histopathology in excised pieces : invaded/non invaded/undetermined | 2-4 weeks |