The Influence of Hip Replacement on Lower Extremity Hemodynamics in Crowe IV Hip Dysplasia Patient

Study Overview
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Brief Summary
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Explore the influence of hip replacement on lower extremity hemodynamics in Crowe Ⅳ hip dysplasia patient.

Detailed Description
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Changes of limb length after total hip replacement is common, especially for Crowe Ⅳ hip dysplasia patient. Such change potentially increases tension of vessel and influence lower extremity hemodynamics. Till now, little is known in this area.

Official Title
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The Influence of Hip Replacement (Subtrochanteric Osteotomy vs. Non-osteotomy) on Lower Extremity Hemodynamics in Crowe IV Hip Dysplasia Patient

Conditions
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Hip Dysplasia

Intervention / Treatment
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* Procedure: total hip replacement with subtrochanteral osteotomy
* Procedure: total hip replacement with no osteotomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Unilateral Crow IV hip dysplasia; Bilateral Crow IV hip dysplasia without osteoarthritis on the other side Exclusion Criteria: Patients with serious medical disease; Patients with lower extremity vascular disease; 3. Patients with severe mental illness.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: total hip replacement with subtrochanteral osteotomy<br>subtrochanteral osteotomy is applied during total hip replacement | Procedure: total hip replacement with subtrochanteral osteotomy<br>* applying subtrochanteral osteotomy during the operation to release the tension of vessels and nerve<br>|
| Sham Comparator: total hip replacement with no osteotomy<br>no osteotomy is applied during total hip replacement. | Procedure: total hip replacement with no osteotomy<br>* just total hip replacement<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hip Harris Score | change of hip harris score scale from baseline(preoperative) to 1 year after surgery. | preoperative, 1 week, 6 weeks, 12 weeks, 24 weeks and 1 year after the surgery. | 
| Leg Length Change | change of Leg Length from baseline(preoperative) to 1 year after surgery. | preoperative, 1 week, 6 weeks, 12 weeks, 24 weeks and 1 year after the surgery. | 
| Radiographic Results | change of Radiographic Results from 1 week after surger to 1 year after surgery | 1 week, 12 weeks, 24 weeks and 1 year after the surgery. | 
| Lower Limb Arterial CT Angiography | change of vascular diameter and vascular cross-sectional from baseline(preoperative) to 1 year after surgery baseline(preoperative) to 12 weeks after surgery. | preoperative, 1 week, 12 weeks after the surgery. | 
| Vascular Ultrasound Examination | change of systolic peak velocity, end-diastolic velocity, pulsation index, resistance index and blood flow from baseline(preoperative) to 1 year after surgery. | preoperative, 1 week, 6 weeks, 12 weeks, 24 weeks and 1 year after the surgery. | 
| Blood Viscosity | change of blood viscosity from baseline(preoperative) to 1 year after surgery. | preoperative, 1 week, 6 weeks, 12 weeks, 24 weeks and 1 year after the surgery. |