Functional Imagery of Sleepwalking

Study Overview
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Brief Summary
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Sleepwalking (also called somnambulism) is a disorder in which only SWS is disrupted. This NREM parasomnia is characterized by inappropriate motor behaviors, usually initiated during arousal from SWS, that induce psychological distress and alter quality of life, leading to fatigue, excessive daytime sleepiness, and objectively impaired vigilance in the morning. The pathophysiology of sleepwalking remains poorly understood. Sleepwalkers had difficulty maintaining stable, consolidated sleep and experienced more arousals and microarousals, specifically from SWS, leading to increased NREM instability, especially during the first sleep cycles. The brain is partially awake, resulting in behavioral manifestations, and partially in NREM sleep, resulting in no conscious awareness of actions. A Single Photonic Emission Computed Tomography (SPECT) study of one sleepwalking episode found increased activation in the posterior cingulate cortex and cerebellum, with deactivation in the frontoparietal associative cortices. Data from intracerebral EEGs during confusional arousals confirmed both local arousal of the motor and cingulate cortices and increased delta activity in the frontoparietal associative cortices. The investigators thus proposed a controlled study of SPECT imagery in 24 sleepwalkers (12 SPECT during a SW episode and 12 SPECT during slow wave sleep and 24 during wakefulness) and 12 controls (during slow wave sleep and wakefulness). SW episodes will be elicited by sleep deprivation condition associated with forced arousal (auditory stimulus). The comparative analyses of SPECT acquisitions between different states (wakefulness, slow wave sleep and SW) and populations (sleepwalkers versus controls) will provide new insights about the complex pathophysiology of SW episodes.

Official Title
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Functional Imagery of Sleepwalking

Conditions
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Sleepwalking

Intervention / Treatment
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* Other: Single-photon emission computed tomography


Participation Criteria
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Eligibility Criteria
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PATIENTS Inclusion Criteria: Subject diagnosed with NREM parasomnia according the international classification of sleep disorders More than one episode per week More than one hypersynchronous delta wave arousal recorded on polysomnographic assessment Affiliated to social security Age between 18 years-old and 39 years-old Exclusion Criteria: Patient taking any psychotropic drug during the two weeks before the inclusion Patient with obstructive sleep apnea Syndrome, restless legs syndrome, nocturnal epilepsy and unstable psychiatric disease. CONTROL GROUP Inclusion Criteria: Affiliated to social security Age between 18 years-old and 39 years-old Exclusion Criteria: Subject taking psychotropic drug during the two weeks before the inclusion Subject with following medical history : NREM parasomnia, neurologic or psychiatric disorder, obstructive sleep apnea syndrome, restless legs syndrome, nocturnal epilepsy.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 39 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Sleepwalker, SW episode<br>Sleepwalker patients undergo single-photon emission computed tomography during a sleepwalking episode. | Other: Single-photon emission computed tomography<br> <br> |
| Other: Sleepwalkers, slow wave sleep<br>Sleepwalker patients undergo single-photon emission computed tomography during slow-wave sleep. | Other: Single-photon emission computed tomography<br> <br> |
| Other: Control group<br>Control subjects undergo single-photon emission computed tomography during slow-wave sleep. | Other: Single-photon emission computed tomography<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Brain metabolism measurement with brain scintigraphy |  | Day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cortical excitability measurement with transcranial magnetic stimulation |  | Day 0 |