Treatment of Atrophic Acne Scars With a Fractional CO2 Laser at 1 Versus 3 Months Intervals

Study Overview
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Brief Summary
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To compare efficacy and adverse effects of fractional CO2 laser of acne scars treatment with 1 versus 3 months intervals

Detailed Description
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Change in scar texture evaluated by blinded evalutaions. Appearance of erythema, oedema, pigmentation, infection after treatment

Official Title
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Treatment of Atrophic Acne Scars With a Fractional CO2 Laser at 1 Versus 3 Months Intervals. A Randomized Controlled Trial With Blinded Response Evaluations

Conditions
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Atrophic Acne Scars

Intervention / Treatment
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* Procedure: Laser


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Have Fitzpatrick skin type I-III. (•Are male or female. Are between 18 and 60 years of age. Mild to severe acne scarring. Are able to read, understand, and sign the Informed Consent. Are willing and able to comply with all follow-up requirements - Exclusion Criteria: Have had active localized or systemic infections within 6 months of enrollment Have compromised ability for wound healing, such as: malnutrition, oral steroid use, history of collagen vascular disease (e.g. lupus, scleroderma, history of keloid formation (raised and thickened scars), atrophic dermatitis (extreme skin irritation or itchiness) or immunologic abnormalities such as vitiligo (white patches of skin due to loss of pigment) Have been treated with lasers, chemical procedures, or other cosmetic procedures on the area to be treated within 6 months of enrollment Pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: CO2 laser at 1 month interval<br>CO2 laser treatment of mild to severe acne scars at 1 month interval | Procedure: Laser<br>* Fractionel CO2 laser: 1 versus 3 months intervals<br>* Other names: Fractionel CO2 laser;|
| Active Comparator: CO2 laser at 3 monrths interval<br>CO2 laser treatment of mild to severe acne scars at 3 month intervals | Procedure: Laser<br>* Fractionel CO2 laser: 1 versus 3 months intervals<br>* Other names: Fractionel CO2 laser;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in scar texture |  | 24 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Appearance of erythema, oedema, pigmentation, infection |  | 24 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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skin texture, efficacy, adverse effects