Unhealthy Alcohol Drinking and Anesthetic Requirement in Women

Study Overview
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Brief Summary
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Unhealthy alcohol drinking is negatively influencing health of people and costing a large number of annual finance via secondhand effects. Additionally, unhealthy alcohol use covers a spectrum that is associated with varying degrees of risk to health. The investigators hypothesized that unhealthy alcohol drinking resulted in significant increase in anesthetic requirement during general anesthesia. This investigation would clarify the association between unhealthy alcohol use and the intraoperative consumption of anesthetics, and provide clinical evidence for preoperative assessment with respect to the alcohol drinking habit.

Official Title
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Unhealthy Alcohol Drinking and Anesthetic Requirement in General Anesthesia in Women

Conditions
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General Anesthesia

Intervention / Treatment
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* Behavioral: Alcohol drinking
* Behavioral: Alcohol drinking
* Behavioral: Alcohol drinking
* Behavioral: Alcohol drinking
* Behavioral: Alcohol drinking


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA physical status I-II Chinese 19-45yr Undergoing general anesthesia Exclusion Criteria: A history of the use of centrally-acting drugs of any sort, chronic pain and psychiatric diseases records. Participants younger than 18yr，older than 45yr or pregnancy was eliminated. Those who were not willing to or could not finish the whole study at any time.

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1<br>No alcohol drinking | Behavioral: Alcohol drinking<br>* Never drinking of alcohol<br>* Other names: Ethanol use;|
| Active Comparator: 2<br>Mild alcohol drinking | Behavioral: Alcohol drinking<br>* Mild drinking of alcohol assessed by alcohol use disorders identification test (AUDIT)<br>* Other names: Ethanol use;|
| Active Comparator: 3<br>Moderate alcohol drinking | Behavioral: Alcohol drinking<br>* Moderate drinking of alcohol assessed by alcohol use disorders identification test (AUDIT)<br>* Other names: Ethanol use;|
| Active Comparator: 4<br>Severe over alcohol drinking | Behavioral: Alcohol drinking<br>* Severe over drinking of alcohol assessed by alcohol use disorders identification test (AUDIT)<br>* Other names: Ethanol use;|
| Active Comparator: 5<br>Alcohol-dependent | Behavioral: Alcohol drinking<br>* Alcohol-dependent assessed by alcohol use disorders identification test (AUDIT)<br>* Other names: Ethanol use;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anesthetic requirements |  | 10 min after completion of operation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Economic assessment |  | 1 day after operation | 
| Odds Ratio of alcohol use and the consumption of anesthetics |  | 1 day after completion of study | 
| Side effects |  | 30 min after completion of the study | 
| Bispectral Index (BIS) value |  | 0, 5, 10, 20, 30, 45, 60, 90 min after anesthesia | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Anesthetics, Sedatives, Analgesics