The Therapeutic Effect of Exercise Training on Patients With Dementia

Study Overview
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Brief Summary
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This study aimed to clarify whether strength training or aerobic training could bring more benefits for patients with dementia

Detailed Description
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Exercise training has been evidenced to bring various of benefits for patients with dementia in past studies. However, whether strength training or aerobic training could bring better benefits has not been confirmed in the past. This study designed to recruit 30 patients with mild dementia in the first year. Every patient will receive strength training using dumbbells, butterfly machine and vertical leg press machine for four weeks. Outcome measures including self care ability, cognitive function, MCP-1, BDNF and IGF-1 levels, and the degree of depression will be recorded before and after the training. In the second year, the investigators also designed to recruit 31 patients with mild dementia. These participants will instead receive aerobic training using stationary bicycle for four weeks. The same outcome measures will be tested as in the first year. Via the results of this study, whether strength training or aerobic training could bring better benefits in dementia patient can thus be elucidated.

Official Title
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The Therapeutic Effect of Exercise Training on Old Patients With Dementia: A Randomized Controlled Trial

Conditions
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Dementia

Intervention / Treatment
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* Device: Strength training
* Device: Aerobic training


Participation Criteria
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Eligibility Criteria
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Inclusion criteria: Patients aged above 65 years old Patients with mild dementia with Mini-mental state examination scoring 15 to 26 Exclusion criteria: Cardiopulmonary diseases or orthopedical conditions that prohibit the patient from receiving exercise training of our programs Cognitive problems that impede the patient to understand and answer the content of our questionnaires.

Ages Eligible for Study
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Minimum Age: 65 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: comparison of therapeutic effect between aerobic and strength training on dementia patient
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Strength training<br>Muscle strength training programs | Device: Strength training<br>* Using dumbbells, butterfly machine and vertical leg press machine for strength training, 12 repetition maximum weight for 12 repetition, three times a day, five days a week, for a total of four weeks<br>|
| Experimental: Aerobic training<br>Aerobic training programs | Device: Aerobic training<br>* Using stationary bicycle to perform cardiopulmonary endurance training in 50-70 heart rate reserve for 20 minutes, five days per week, for a total of four weeks<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Barthel index | To evaluate function of activities of daily living, range from 0-100, higher values represent a better outcome | 4 weeks | 
| Mini-mental state examination | To evaluate cognitive function, range from 0-30, higher values represent a better outcome | 4 weeks | 
| Montreal Cognitive Assessment | To evaluate cognitive function, range from 0-30, higher values represent a better outcome | 4 weeks | 
| Geriatric Depression Scale | To evaluate patient's depression status, range from 0-15, higher values represent a worse outcome | 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Concentration of serum brain derived neurotrophic factor (BDNF) | Increasing BDNF level is related to preventing neurodegeneration. | 4 weeks | 
| Concentration of plasma insulin-like growth factor-1 (IGF-1) | Lower plasma level of IGF-1 is associated with an increased risk of developing Alzheimer's dementia, and higher levels of it may protect against neurodegeneration. | 4 weeks | 
| Concentration of plasmamonocyte chemotactic protein-1 (MCP-1) | The elevation of MCP-1 concentration usually means the progression of systemic inflammation. | 4 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Dementia