Detection of Ultrasound Contrast Signals in the Cerebral Circulation

Study Overview
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Brief Summary
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To Determine whether transcranial ultrasound can detect the presence of intravenously injected microbubbles used routinely for dobutamine stress echocardiography.

Detailed Description
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The purpose of this study is to determine whether the intravenous microbubbles used to improve border delineation during dobutamine stress echocardiographies (DSE) can be detected within the cerebral circulation.

Official Title
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Detection of Ultrasound Contrast Signals in the Cerebral Circulation During Stress Echocardiography

Conditions
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Brain Vascular Disorders, Coronary Artery Disease

Intervention / Treatment
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* Procedure: Ultrasound on Temporal Bone


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: male or female age >19 years of age scheduled for a stress echocardiogram negative urine pregnancy test within two hours of ultrasound contrast administration required for females of childbearing age unless post-menopausal or with evidence of surgical sterilization be conscious and coherent, and able to communicate effectively with trial personnel Exclusion Criteria: pregnant or lactation life expectancy of less than 2 months or terminally ill Known or suspected hypersensitivity to ultrasound contrast agent used for the study complicated hemodynamic instability Known left main disease

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1 Transcranial imaging using Doppler Ultrasound<br>Transcranial imaging using Doppler ultrasound | Procedure: Ultrasound on Temporal Bone<br>* All Patients undergoing dobutamine stress echocardiography have an intravenous line placed and a continuous infusion of a commercially available contrast agent administered. Prior to contrast infusion, baseline transcranial ultrasound images at 0.4 mechanical index using low mechanical index pulses and color Doppler will be performed and recorded. After this the contrast infusion will begin, and resting cardiac images will occur.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Detect abnormalities in cerebral blood flow | All Patients undergoing dobutamine stress echocardiography have an intravenous line placed and a continuous infusion of a commercially available contrast agent administered. Prior to contrast infusion, baseline transcranial ultrasound images at 0.4 mechanical index using low mechanical index pulses and color Doppler will be performed and recorded. After this the contrast infusion will begin, and resting cardiac images will occur. | immediate | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| if cerebral vascular disease is detected it would lead to further testing that may better identify abnormalities. | All Patients undergoing dobutamine stress echocardiography have an intravenous line placed and a continuous infusion of a commercially available contrast agent administered. Prior to contrast infusion, baseline transcranial ultrasound images at 0.4 mechanical index using low mechanical index pulses and color Doppler will be performed and recorded. After this the contrast infusion will begin, and resting cardiac images will occur. | within 30 minutes |