linjc16/ctgov huggingface dataset:
Evaluate Efficacy of Certolizumab in Crohn's Patients With Draining Fistulas

Study Overview
=================
Brief Summary
-----------------
To investigate the clinical efficacy of certolizumab pegol for fistula closure in Crohn's disease subjects with active draining fistulas.

Official Title
-----------------
A Phase IIIB Multicenter, Open Label, Randomized Clinical Trial Evaluating Efficacy of Certolizumab Pegol, a PEGylated Fab Fragment of Humanized Antibody to Tumor Necrosis Factor (TNF) in Crohn's Disease Patients With Draining Fistulas.

Conditions
-----------------
Crohn Disease

Intervention / Treatment
-----------------
* Drug: Certolizumab pegol


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with single or multiple fistulas, including perianal and enterocutaneous fistulas for at least 3 months as a complication of Crohn's disease Exclusion Criteria: Symptomatic obstructive intestinal strictures, bowel resection, proctocolectomy or total colectomy, abscesses present at screening, current total parenteral nutrition, short bowel syndrome. All the concomitant diseases or pathological conditions that could interfere with Crohn's disease assessment or to be harmful for the well being of the patient. Previous clinical trials and previous biological therapy that could interfere with the results in the present clinical trial

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Certolizumab pegol|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Investigation of Clinical efficacy of certolizumab pegol for fistula closure, as measured by the proportion of patients with fistula improvement after 16 weeks of treatment. |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Investigation of Clinical efficacy of certolizumab pegol for maintenance of fistula closure. |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Crohn Disease, Certolizumab pegol, Fistula
Rapid Opiate Detoxification and Naltrexone Induction Using Buprenorphine - 2

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to develop a clinical protocol to detoxify patients from opiates to naltrexone using buprenorphine and to develop pilot data for a grant application for a controlled study of the efficacy of the new clinical protocol for outpatients.

Official Title
-----------------
Rapid Opiate Detoxification & Naltrexone Induction Using Bup.

Conditions
-----------------
Opioid-Related Disorders

Intervention / Treatment
-----------------
* Drug: Buprenorphine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Males/Females, ages 21-50. Opiate dependence according to DSM-IV criteria. Self-reported use within the last 30 days. Agreeable to conditions of study and signed informed consent. Exclusion Criteria: psychiatric disorder that requires medication therapy. History of seizures. Pregnant and/or nursing women. Dependent on etoh or benzodiazepines or other sedative-hypnotics. Acute hepatitis. Other medical conditions that deem participation to be unsafe.

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: buprenorphine<br>depot buprenorphine | Drug: Buprenorphine<br> <br> |
| Experimental: buprenorphine and ultra-low dose naloxone<br>depot buprenorphine and naloxone | Drug: Buprenorphine<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Opiate craving | opiate craving is measured on each test day. | 10 test days | 
| Opiate withdrawal symptoms | opiate withdrawal symptoms are documented for each test day | 10 test days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Opioid-Related Disorders
Predictability of Distalization and Derotation of the Carriere Motion Appliance.

Study Overview
=================
Brief Summary
-----------------
To analyze the distalization or distal tooth displacement and derotation angle produced by Carriere Motion Appliance® (CMA) by using a repeatable and reproducible measurement digital technique.

Detailed Description
-----------------
15 patients with Class II molar and canine relationship were submitted to orthodontic treatment with CMA. All patients were exposed preoperatively (STL1) and postoperatively (STL2) to a digital impression and afterwards were uploaded into a specific cephalometric software to allow the automatic mesh networks alignment of the STL digital files. Subsequently, the distal tooth displacement of upper canines and first upper molars and also the derotation angle of first upper molars were measured. The repeatability and reproducibility were analyzed by Gage R&R statistical analysis.

Official Title
-----------------
Predictability of Distalization and Derotation of the Carriere Motion Appliance. A Clinical Study

Conditions
-----------------
Dental Malocclusion

Intervention / Treatment
-----------------
* Device: Carriere Motion Appliance®


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Growing patients Late mixed dentition or permanent dentition Fully erupted definitive molars No history of previous orthodontic treatment Complete pre- and post-treatment records (digital study models) Dental Class II relationship. Exclusion Criteria: Permanent dentition Adults Dental Class I, III

Ages Eligible for Study
-----------------
Minimum Age: 10 Years
Maximum Age: 17 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: This study included 15 patients with Class II molar relationship and Class II canine relationship treated using Carriere Motion Appliance®.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Canine and molar distalization and molar derotation<br>Evaluating the canine and molar distalization and molar derotation in dental Class II patients who where submitted to Carriere Motion Appliance® for a mean of 4 months. | Device: Carriere Motion Appliance®<br>* To analyze the distalization or distal tooth displacement and derotation angle produced by Carriere Motion Appliance® in a period of 4 months.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean Canine Distalization | 1.193 mm | 4 months | 
| Mean Molar Distalization | 1.34 mm | 4 months | 
| Mean Molar Derotation | 6.333º | 4 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Class II malocclusion, Carriere Motion Appliance, Distalization, Derotation
Using Near-infrared Spectroscopy (NIRS) Monitor to Noninvasively Evaluate Hepatic Venous Saturation

Study Overview
=================
Brief Summary
-----------------
Clinical studies are required to validate the hepatic NIRS monitor with other regional and global hemodynamic parameters and to evaluate its clinical use for continuous non-invasive hemodynamic monitoring. Using newer NIRS sensors the correlation between hepatic regional oxygen saturation and hepatic venous oxygen saturation (SvHO2) needs to be determined. If found to correlate then the NIRS can be used to evaluate early liver transplant failure and/or hepatic artery thrombosis, used as an early marker for shock, and necrotizing enterocolitis, and finally used in the outpatient setting to evaluate patients with chronic liver pathologies. If our validation study finds that NIRS monitors are an appropriate marker of hepatic venous saturation then it will lead to further clinical studies.

Official Title
-----------------
Using Near-infrared Spectroscopy (NIRS) Monitor to Noninvasively Evaluate Hepatic Venous Saturation

Conditions
-----------------
Congenital Heart Disease, Arrhythmia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All pediatric patients (0-18yrs) undergoing cardiac catheterization by the participating interventional cardiologist at Phoenix Children's Hospital will be recruited for this investigation Exclusion Criteria: emergency catheterizations, procedures in hemodynamically unstable patients, patients with repeat catheterizations that have already enrolled in the study

Ages Eligible for Study
-----------------
Minimum Age: 1 Day
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cardiac Cath<br>All pediatric patients requiring cardiac catheterization who consent | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Degree of Hepatic Venous Saturation using NIRS | The investigators strive to discover a noninvasive measure of hepatic venous saturation. The use of NIRS monitoring for global oxygen saturation has been used in the inpatient population. This project aims to use hepatic NIRS monitor as a surrogate marker for hepatic and splanchnic oxygenation. | 5 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
hepatic blood,, cardiac cath,, hepatic oxygenation,, pediatrics
Innervated Sensory Cross-Finger Flap

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to introduce a new operative technique for reconstruction of fingertip degloving injury.

Detailed Description
-----------------
Incidence of fingertip degloving injury is common and can result in functional morbidity. A cross-finger flap based on the dorsal branch artery (DBA) including sensory nerve is a useful reconstructive technique.In our modification, the innervated sensory flap is vascularized by the DBA, both its pedicle is narrow and its coverage is extended, the projecting tip of exposed distal phalanx of adjacent digits therefore can be wrapped.

Official Title
-----------------
The Innervated Sensory Cross-finger Flap Based on the Dorsal Branch Artery for Reconstruction of Fingertip Degloving Injury

Conditions
-----------------
Transplantation

Intervention / Treatment
-----------------
* Procedure: The innervated sensory cross-finger flap


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: the fingertip degloving injury including the thumb; age between 12 and 59 years; no life-threatening associated injuries. Exclusion Criteria: age greater than 60 years; smoking; Dupuytren's contracture; peripheral arterial disease and other vascular disorders.

Ages Eligible for Study
-----------------
Minimum Age: 12 Years
Maximum Age: 59 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: The innervated sensory cross-finger flap|The innervated sensory cross-finger flap is a modified method for repair fingertip degloving injury|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| static 2-point discrimination test and the range of motion are used for evaluation of outcomes |  | at least 4 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cross-finger flap, finger injuries, fingertip reconstruction, proper digital artery, proper digital nerve.
Study of Iron Accumulation Measured in MRI in Non-pathological Aging

Study Overview
=================
Brief Summary
-----------------
To study the correlation between the iron load in brain, measured in MRI, and the age of healthy subjects Secondary objectives are to study the correlations between the iron load in cortical brain regions and (i) the cognitive performances, (ii) markers of aging (MRI, EEG, OCT, biology),and (iii) demographical factors involved in iron load.

Official Title
-----------------
Study of Iron Accumulation Measured in MRI in Non-pathological Aging

Conditions
-----------------
Healthy Aging

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Men or women between 18 and 95 years old French speaker with capability to understand the instructions Health insurance Exclusion Criteria: Pregnancy minor subject no informed consent agreement subject enrolled in pharmaceutic study or exclusion period MRI contra-indications Neurological or psychiatric disorders MOCA < 26 Psychotropic drugs More than 3 MRI exams More than 1 neuropsychological assessment (same cognitive tests) in the last 12 months Unable to follow the entire protocol according to the investigator

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 95 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation coefficient between iron load in MRI and age |  | baseline |
Study of People's Profile Living in France Who Could be Interested in the Use of a Nanohydroxyapatite Toothpaste

Study Overview
=================
Brief Summary
-----------------
Nano-hydroxyapatite is an interesting candidate to be a substitute for fluor in toothpastes or a complement to fluorides in order to prevent caries. The objective of this transversal descriptive study is to evaluate the profiles of people living in France who could be interested in using a nano-hydroxyapatite based toothpaste. Participants in this transversal descriptive study have been chosen by a self-administered method. Before answering 16 questions, the participants were asked to watch a short video describing the main concepts to know about fluoridated toothpastes and nano-hydoxyapatite toothpastes. Pros and cons of each one them were mentioned. In order to compare the answers, pivot tables have been produced.

Official Title
-----------------
Study of People's Profile Living in France Who Could be Interested in the Use of a Nanohydroxyapatite Toothpaste

Conditions
-----------------
Dental Caries, Hydroxyapatite

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Internet acces Interested in the Use of a Nanohydroxyapatite Toothpaste Exclusion criteria: Age < 18 years Peoples who no lives in France

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of people interested in using toothpaste based on nano-hydroxyapatite | Number of people interested in using toothpaste based on nano-hydroxyapatite | 1 day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cariostatic Agents, Toothpaste
Comparison Of Suture Materials on Sectio Scars (COSMOSS)

Study Overview
=================
Brief Summary
-----------------
This multicenter prospective randomized controlled trial aims to investigate the ishtmocele rates after c-section delivery depending on using different suture materials for the uterine closure.

Detailed Description
-----------------
The study involves 5 health centers (two universities, three private hospitals). Patients who will undergo their first cesarean section because of any etiology (except emergent cases) will be included in the study. Operation Nurse will randomize the patients into two groups depending on the monofilament or poly filament suture material. Patients will be checked by transvaginal ultrasound on a postoperative day one, postoperative first month, and postoperative sixth month. As the primary result, the istmocele rates will be compared between the study groups.

Official Title
-----------------
COSMOSS Study, Comparison Of Suture Materials on Sectio Scars. A Multicenter Prospective Randomized Controlled Study

Conditions
-----------------
Uterine Scar

Intervention / Treatment
-----------------
* Procedure: Uterine Closure with monofilament or polyfilament suture materials


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18-40 yrs women Primary elective cesarean section First delivery Without any systemic diseases Exclusion Criteria: emergent delivery previous c-section history congenital uterine abnormality

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Monofilament Suture Group<br>Monofilament sutures will be used for uterine closure. | Procedure: Uterine Closure with monofilament or polyfilament suture materials<br>* Postoperative 6th-month isthmocele rates<br>|
| Active Comparator: Polyfilament Suture Group<br>Polyfilament sutures will be used for uterine closure. | Procedure: Uterine Closure with monofilament or polyfilament suture materials<br>* Postoperative 6th-month isthmocele rates<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Isthmocele Rate | diagnosis of isthmocele during 6th month ultrasound check. | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
suture, cesarean section, isthmocele, uterine scar
Scapular Stabilization Exercises on the Clavicular Movement

Study Overview
=================
Brief Summary
-----------------
This study was planned to indicate efficiacy of the scapular stabilization exercises on the clavicula movements.

Detailed Description
-----------------
All subjects in the study were evaluated for range of motion (Goniometer), muscle strength (Manuel Muscle Strength Test), angular displacements of clavicula during abduction and skapular plan elevation of arm (Video Analysis Method), disability of the arm (Quıck Dash Turkish). The study was applied in two groups for three times per week during 8 weeeks.

Official Title
-----------------
The Effect of the Scapular Stabilization Exercises on the Clavicular Movement on the Girl Adolescents,

Conditions
-----------------
Clavicle

Intervention / Treatment
-----------------
* Other: scapular stabilization exercises


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Having no ınjury for lower anda upper extremites Exclusion Criteria: Having ınjury for lower anda upper extremites

Ages Eligible for Study
-----------------
Minimum Age: 10 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: scapular stabilization exercises<br>the effect of the scapular stabilization exercises on clavicular movement | Other: scapular stabilization exercises<br>* the effect of the scapular stabilization exercise on the clavicular motion on the adolescent girls<br>|
| No Intervention: no intervention<br>no intervention | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the effect of the scapular stabilization exercises | clavicular elevation and depression | 1 Year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
adolescent,, clavicula,, scapula,, exercise