linjc16/ctgov huggingface dataset:
Efficacy of Copper in Reducing Health-Acquired Infections in a Pediatric Intensive Care Unit

Study Overview
=================
Brief Summary
-----------------
Healthcare-acquired infections (HAI) cause substantial patient morbidity and mortality. Commonly touched items in the patient care environment harbor microorganisms that may contribute to HAI risk. The purpose of this study is to assess whether placement of copper-alloy surfaced objects in a pediatric intensive care unit (PICU) reduce risk of HAI in comparison with non-copper surfaced objects.

Official Title
-----------------
Efficacy of Copper in Reducing Health-Acquired Infections and Microbial Burden as Measured on High Touch Surfaces in a Pediatric Intensive Care Unit. A Controlled Clinical Trial.

Conditions
-----------------
Nosocomial Infections

Intervention / Treatment
-----------------
* Other: Copper-alloy surfaced objects


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patient admitted to PICU stay at PICU > 24 hours informed consent by parent/legal representative Exclusion criteria: none

Ages Eligible for Study
-----------------
Minimum Age: 7 Days
Maximum Age: 180 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Non copper standard surfaced objects<br>Rooms assigned to standard surfaced objects | |
| Experimental: Copper-alloy surfaced objects<br>Rooms furnished with copper surfaced objects, i.e. bed rails, bed rail levers, IV poles, nurse workstation, clipboards, sink handles. | Other: Copper-alloy surfaced objects<br>* Room assigned to the Experimental arm will be furnished with copper-alloy surfaced objects,i.e. bed-rails, bed-rail levers, IV poles, nurse workstation, HCW clipboards, sink handles.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hospital-Acquired Infections (HAI) incidence density / 1,000 patient-days |  | Participants will be followed for the duration of hospital stay, an expected average of 6 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Microbial Burden measured on high-touch copper and non-copper surfaced objects | Total microbial burden and selected bacteria (MRSA,VRE) will be measured twice a month in all bedrails and sink handles of the PICU study site. | 1 year study duration | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Copper, Health-Acquired Infections, Bacterial Load, Intensive Care Units, Pediatric
Mindfulness in the OR

Study Overview
=================
Brief Summary
-----------------
The purpose of this research study is to understand the effect of a short mindfulness video on self perceived performance in the OR. Specifically, assessing the effectiveness of brief mindfulness intervention on physician focus, anxiety and perceived performance at the time of a procedure through a survey containing a modified flow state scale and modified applied mindfulness process scale

Official Title
-----------------
Mindfulness in the OR: Can an Abbreviated Mindfulness Skill Improve a Surgeon's Focus, Anxiety and Performance in the OR?

Conditions
-----------------
Performance at Work

Intervention / Treatment
-----------------
* Behavioral: Mindfulness
* Behavioral: Video


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: practicing physicians or medical trainees employed in a hospital setting providing surgeries in an operating room setting. Exclusion Criteria: • practitioners involved in counseling roles

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Mindfulness<br> | Behavioral: Mindfulness<br>* Participants will view a brief mindfulness video<br>|
| Placebo Comparator: Control<br> | Behavioral: Video<br>* Participants will view a control video<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Perceived flow | Perceived flow will be assessed using a modified flow state scale after case. Items are rated from Strongly disagree to Strongly agree. Items are summed and scored. | At the end of the procedure, up to 5 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Perceived application of mindfulness | Perceived mindfulness will be assess using a modified applied mindfulness process scale. Items are rated never, rarely, sometimes, often and always. Items are summed and scored. | at the end of the procedure, up to 5 hours |
Phase I/II Study of Escalating Doses of Idarubicin Orally Given With Oral Cyclophosphamide, Etoposide, Prednisolone and Intravenous Rituximab in Elderly Patient With Disseminated High Grade Non Hodgkin Lymphoma

Study Overview
=================
Brief Summary
-----------------
R-CHOP with doxorubicin is the standard first line treatment of high grade non-Hodgkin's lymphoma. In order to avoid central venous system insertion and reduce hospitalization time in elderly patients, we developed an oral chemotherapy treatment:  OROCIEPtrial. Nineteen patients were enrolled and 127 chemotherapy cycles were available for toxicities. The estimated two-years overall survival was 74%. The main haematological toxicity was neutropenia. This study is still ongoing to confirm recommended dose of oral anthracycline.

Conditions
-----------------
High Grade Lymphomas CD20 Positive

Intervention / Treatment
-----------------
* Drug: idarubicin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: CD20-positive diffuse large B-cell lymphoma.WHO classification (55) Written informed consent Age > 65 and < 80 years Performance status (ECOG) <3 measurable disease Serology HIV negative, Hepatites B, Hepatites C negative Exclusion Criteria: Serology HIV positive, Hepatite B positive, Hepatite C positive Cardiac failure.

Ages Eligible for Study
-----------------
Minimum Age: 65 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: idarubicin<br> | Drug: idarubicin<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximum tolerated dose of idarubicin |  | 9 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Remission rate after 4 cycles and 8 cycles |  | 9 months |
The Application Value of Non-contact Infrared Thermometers in Temperature Screening in the General Population

Study Overview
=================
Brief Summary
-----------------
The first epidemic of 2019 novel coronavirus (2019-nCoV)-infected pneumonia(NCIP) in Wuhan, China, has attracted global attention because of its strong transmission ability and certain fatality. Analyzing the clinical data of hospitalized patients with 2019-nCoV infection, the current studies found that fever, fatigue and dry cough were common symptoms, and 43.8% of the patients showed fever before admission. Some scholars emphasize that the most effective means to control the outbreak are early detection, early isolation, early diagnosis and early treatment. In the face of the pressure that a large number of people need rapid screening and the deficiency that the forehead temperature measurement is easily affected by the environment, the investigators would like to explore the accuracy and advantages of wrist temperature measurement in different environments and conditions in this period. And determine the thresholds of non-contact infrared thermometer for the screening of patients with fever, in order to provide clinical indicators for further detection of patients with suspected fever.

Official Title
-----------------
The Application Value of Non-contact Infrared Thermometers in Temperature Screening in the General Population: a Real-world, Prospective, Observational Study

Conditions
-----------------
Non-contact Infrared Thermometer; Rapid Screening

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients, family members of patients, and medical staff Exclusion Criteria: age <= 18 years Wearing hearing aid, having a cerumen Soft tissue infection, trauma patients Missing data

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients, family members of patient, medical staff<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The Comparison of accuracy between wrist temperature and forehead temperature. | The investigators used non-contact infrared thermometers to measure the value of wrist and forehead temperature in patients, family members of patients, medical staff. They record the value of temperature in the population and environment temperature. | cross-sectional analyses in 2020 |
Noninvasive Skin Spectroscopy for Diabetes Screening

Study Overview
=================
Brief Summary
-----------------
The objective of this study is to assess the performance of a noninvasive device for the early screening of Diabetes Mellitus.

Detailed Description
-----------------
Approximately 18 million people have Type II diabetes, and of these, an estimated thirty-five percent are unaware of their condition. This translates to roughly 6.3 million undiagnosed cases worldwide in 2002. Many diagnoses are made years after the onset of the disease. This allows progression of the vascular lesions that arise during the time of uncontrolled glucose levels. As a result, microvascular retinopathy, nephropathy, and neuropathy are on the rise, as well as macrovascular complications such as: coronary heart disease, and cerebral vascular accidents. The prevalence and trends of diabetes underscore the need for effective and widespread screening. Our fluorescence based system under development will noninvasively measure skin glycation end products that are known to be strongly correlated with diabetes status and complications. Since the test would be painless and require no patient fasting, significant obstacles to screening compliance would be mitigated. The system offers hope for a screening test that is more sensitive and specific than the invasive tests currently used for diabetes screening (Oral Glucose Tolerance Test (OGTT) and the Fasting Plasma Glucose (FPG) test).

Official Title
-----------------
Noninvasive Skin Spectroscopy for Diabetes Screening

Conditions
-----------------
Prediabetic State, Diabetes Mellitus, Type 2

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Volunteers without Diabetes. Volunteers at risk for developing Type II diabetes. 18 years of age and older. Exclusion Criteria: Under 18 years of age. Those diagnosed with Diabetes.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Comparison Between Respiratory Therapy With Cough Assist Technique and Usual Respiratory Therapy in Intensive Care Patients Suffering of Neurologic Disorder

Study Overview
=================
Brief Summary
-----------------
The present study aims to compare the efficiency of respiratory therapy with cough assist and the efficiency of usual respiratory therapy in intensive care patients suffering of neurologic disorder and cough ineffectiveness. The investigators hypothesis is that cough assist is more efficient than usual respiratory care in this group of patients.

Official Title
-----------------
Comparison Between Respiratory Physiotherapy With Cough Assist Technique and Usual Respiratory Care in Intensive Care Patients Suffering of Neurologic Disorder

Conditions
-----------------
Neurologic Disorder

Intervention / Treatment
-----------------
* Device: Cough assist (Philips,respironics)
* Other: Usual respiratory therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Peak flow < 270 ml if the patient has one of the following diagnostic: post neurosurgery status, cerebral trauma, tetraparesia or tetraplegia Exclusion Criteria: Death expected in the following 24h Bulbar dysfunction if extubated pneumothorax intracerebral mass effect elevated intracranial pressure

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Respiratory therapy with cough assist<br> | Device: Cough assist (Philips,respironics)<br> <br> |
| Active Comparator: Usual respiratory therapy<br> | Other: Usual respiratory therapy<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of stay in intensive care unit |  |  | 
| Number of additional unplanned respiratory therapy treatment |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of stay in the hospital |  |  | 
| Pulmonary infection |  |  | 
| Oxygenation parameters before and after respiratory therapy |  |  | 
| Intracranial pressure elevation during respiratory therapy if an intracerebral pressure monitoring is available |  |  | 
| Need of reintubation in the 48h following successful intubation |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Respiratory therapy in neurologic disorder
Cortisol Diurnal Variation and the Risk for Developing Post Traumatic Stress Disorder

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to examine a possible link between the time of day of exposure to a traumatic event and the risk of developing post-traumatic stress disorder. Clinical and biological correlates will also be examined from this perspective.

Conditions
-----------------
Posttraumatic Stress Disorders, Cortisol Diurnal Variation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Persons 21-65 years old, who have been exposed to an event meeting the following DSM-IV criterion for Acute Stress Disorder: Criteria A.1 and A.2 At least one of Criteria B1-5A.1 Who provide written, informed consent to participate in the study. Exclusion Criteria: Physical injury that would contraindicate participation or interfere with a subject's ability to give informed consent or cooperate with the screening or collection of initial measures. Examples include severe burn injury, life-threatening medical or surgical condition, condition requiring surgical intervention under general anesthesia, as indicated by Abbreviated Injury Scale (AIS), or by clinical judgment; Head injury involving confusion, loss of consciousness, or amnesia; Medical conditions such as extreme obesity, psoriasis, herpes, Cushing's syndrome, current infectious disease, current viral disease, tuberculosis, unstable diabetes or hypertension, myasthenia gravis, and heart failure. Persons taking medications that can interfere with the HPA axis (e.g.,steroids, betablockers,indomethacin) will be excluded; Weight below 45 or above 120 kg. Pregnancy (in suggestive cases, a pregnancy test will be performed); Traumatic exposure that reflects ongoing victimization (e.g., domestic violence) to which the subject is likely to be re-exposed during the study period. Overt psychopathology, intoxication, or under the influence of substances. Evidence or history of schizophrenia, bipolar, other psychotic condition; Prior history of PTSD; Current or past history of dementia, amnesia, or other cognitive disorder predating trauma exposure; Assessed serious suicide risk. -

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Men/Women, 21-65, following exposure to a traumatice event<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Development of Posttraumatic stress disorder |  | six months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Biological correlates of post-traumatic stress disorder |  | six months | 
| correlation between development of Posttraumatice stress disorder and time of traumatic event |  | six months |
Obstructive Sleep Apnea Syndrome and Attention Executive Function Disturbances

Study Overview
=================
Brief Summary
-----------------
Studies demonstrate that sleep disturbances are associated with cognitive dysfunction and attention deficit. However the correlation between the severity of obstructive sleep apnea and the degree of cognitive dysfunction was not demonstrated. Our hypothesis is that patients suffering from a more severe sleep apnea will demonstrate a greater degree of cognitive dysfunction.

Detailed Description
-----------------
Studies demonstrate that sleep disturbances are associated with cognitive dysfunction and attention deficit. However the correlation between the severity of sleep disturbances and the degree of cognitive dysfunction was not demonstrated.We intend to study 80 patients with various degrees of obstructive sleep apnea. All patients will undergo executive cognitive tests as well as tests to assess for levels of depression, anxiety and attention.

Official Title
-----------------
Obstructive Sleep Apnea Syndrome and Attention Executive Function Disturbances

Conditions
-----------------
Obstructive Sleep Apnea

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Apnea hypopnea index>5 Age 20 - 70 years Exclusion Criteria: Pregnant women Known chronic cardiovascular or pulmonary disease Patients s/p CVA or brain damage Known depression or other psychiatric disorder Patients with severe cognitive dysfunction (MMSE<25) Patients receiving stimulants, antipsychotic or anti-depression medications

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Iplasma IL6, Procalcitonin and VEGF and Dialysate Level in CAPD Patients

Study Overview
=================
Brief Summary
-----------------
The aim of study was to evaluated the correlation between plasma levels, dialysate appearance rate of VEGF, inflammatory cytokines (IL- 6, procalcitonin) and PSTR, dialysis adequacy in CAPD patients.

Detailed Description
-----------------
This cross -sectional study measured IL-6, procalcitonin and VEGF level in plasma and overnight effluent. PSTR of small solutes was evaluated by standard peritoneal equilibration test (standard PET). Weekly Kt/V and creatinine clearance (CCr ) were evaluated in all patients.

Official Title
-----------------
Interleukin-6, Procalcitonin and Vascular Endothelial Growth Factor in Plasma and Dialysate Correlate With Peritoneal Solute Transport and Dialysis Adequacy in CAPD Patients

Conditions
-----------------
Chronic Kidney Disease

Intervention / Treatment
-----------------
* Other: Measure plasma and dialysate level of IL-6, procalcitonin and VEGF


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Stable CAPD patients without previous history of peritonitis Exclusion Criteria: HIV Other infections, tuberculosis or on immunosuppressive drugs, Autoimmune disease, Cancer Diagnosis of permanent ultrafiltration failure .

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Measure plasma and dialysate level of IL-6, procalcitonin and VEGF|correlation between plasma levels, dialysate appearance rate of VEGF, inflammatory cytokines (IL- 6, procalcitonin) and PSTR, dialysis adequacy in CAPD patients.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| plasma level of VEGF, IL-6 and procalcitonin with the PSTR and dialysis adequacy in CAPD patients | measure in pg/ml | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cytokines in diabetic and non-diabetic group | All cytokines in plasma and blood | 2 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
CAPD, Peritoneal solute transport rate, Dialysis adequacy