Exercise Training to Atrial Fibrillation

Study Overview
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Brief Summary
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To test the impacts of different exercise training programs to the cardiopulmonary function, muscle metabolism, and body mass composition

Detailed Description
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Atrial fibrillation (AF) has been a global threat due to its increasing incidence and prevalence, and also its potential complications of embolic stroke and heart failure, and therefore has a great impact on life expectancy and quality of life. AF with preserved ventricular function is associated with exercise intolerance, and the effect of physical training had shown to improve life quality and heart function in the population. However, the optimal physical training modalities and intensities are not well studies. Here we conduct a prospective, randomized, and interventional trial to investigate the effects of different exercise training programs to the burden of AF. We also exploit advanced imaging modalities, including dual x-ray absorptiometry and muscle magnetic resonance, to explore the change of body mass compositions. With this project, we will be able to explore the effects of different physical exercise modalities to the burden of AF and heart function, and also build up a best exercise training program, specific for this population.

Official Title
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The Impact of Exercise Training to Patients With Atrial Fibrillation

Conditions
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Atrial Fibrillation

Intervention / Treatment
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* Behavioral: Aerobic training
* Behavioral: Resistance training
* Behavioral: Control physical exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Paroxysmal or persistent atrial fibrillation Daily activity below moderate intensity < 300 minutes or high intensity < 150 minutes per week. Exclusion Criteria: Active infection. Implant cardiac pacemaker. Uncontrolled hypertension. Cardiopulmonary contraindication to exercise training, such as decompensated heart failure, acute pulmonary edema, unstable angina, uncontrolled arrhythmia causing hemodynamic compromise, symptomatic severe aortic stenosis, suspected dissecting aortic aneurysm, severe pulmonary hypertension, acute myocarditis, endocarditis or pericarditis, uncontrolled asthma and SpO2 < 90% at rest on room air. Inability to follow verbal command or to walk on treadmill or use stationary bike.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Aerobic training<br> | Behavioral: Aerobic training<br>* Aerobic training<br>|
| Active Comparator: Resistance training<br> | Behavioral: Resistance training<br>* Resistance training<br>|
| Placebo Comparator: Control<br> | Behavioral: Control physical exercise<br>* Control physical exercise<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| AF burden | AF burden on 14 day ECＧ | 5 months | 
| CPET/6 minute walking test | CPET/6 minute walking test | 5 months | 
| DEXA/muscle MRI | DEXA/muscle MRI | 5 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Atrial Fibrillation, weight training, aerobic training, cardio-pulmonary function