TAP Blocks vs. IV Lidocaine for Kidney Transplants

Study Overview
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Brief Summary
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This study will compare continuous intravenous lidocaine against single-injection transversus abdominis plane (TAP) block as a modality for postoperative analgesia in kidney transplant surgery.

Detailed Description
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This study is a non-inferiority trial designed to assess the analgesic efficacy of an intravenous (IV) lidocaine infusion against single-injection transversus abdominis plane (TAP) block in patients undergoing kidney transplant surgery. The investigators propose a study of 124 subjects randomized into two groups. The control group will receive a TAP block. The study group will receive a continuous IV lidocaine infusion. The investigators hypothesize that there will be no statistically significant difference in postoperative opioid consumption between the two groups in the first 24 hours.

Official Title
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A Comparison of Transversus Abdominis Plane Blocks Versus Continuous Intravenous Lidocaine for Kidney Transplant Surgery

Conditions
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Postoperative Pain

Intervention / Treatment
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* Procedure: Transversus Abdominis Plane Block
* Drug: Intravenous Lidocaine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Kidney transplant recipient >18 years old Consent to participate Exclusion Criteria: <18 years old Refusal to participate Chronic opioid use Seizure disorder Allergy to local anesthestics Severe hepatic disease

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: TAP Block<br>Single-injection transversus abdominis plane block | Procedure: Transversus Abdominis Plane Block<br>* Single-injection transversus abdominis plane block with 30 mL of 0.25% Bupivacaine with 1:400,000 epinephrine<br>* Other names: TAP Block;|
| Active Comparator: IV Lidocaine<br>Continuous intravenous lidocaine infusion | Drug: Intravenous Lidocaine<br>* Continuous intravenous lidocaine infusion<br>* Other names: Continuous intravenous lidocaine;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Opioid Consumption | Total opioid utilization | 0-24 Hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain Scores | Numerical Rating Scale Pain Scores (Range: 0-10, where 0 is no pain and 10 is the worst pain) | 0-48 Hours | 
| Opioid Consumption | Total opioid utilization | 24-48 Hours | 
| Opioid-Related Adverse Events | Nausea, Vomiting, Pruritis, Respiratory Depression, Constipation | 0-48 Hours | 
| Block/Infusion-Related Adverse Events | Local Anesthetic Systemic Toxicity | 0-48 Hours | 
| Opioid Usage | Use of prescribed opioids | 30 days from discharge |