Comparative Genomic Profiling of Lung Adenocarcinoma in Asians and Caucasians: A Propensity Matched Analysis

Study Overview
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Brief Summary
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Lung adenocarcinomas (LUADs) from Asian ancestry are reported to have different genomic architectures compared with LUADs from Caucasian ancestry. However, due to lack of available cases, few studies controlled the clinical attributes during the comparisons of the genomic alterations. In this study, the investigators will identify Asian LUADs patients who had broad-panel next-generation sequencing (NGS) performed on their primary tumor between January 2018 and December 2019 at the department of thoracic surgery of Peking University People's Hospital. Then, Caucasian LUADs patients who had targeted NGS (Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets [MSK-IMPACT]) will be identified in the GENIE database, which consists of 6673 primary lung adenocarcinoma samples with clinical annotations. Finally, genomic alterations regarding somatic mutations, copy number variations, fusions, mutational signatures, oncogenic pathways, and therapeutic actionability will be comprehensively compared between these two cohorts after adjusting age, sex, smoking status, and pathologic stage using propensity score matching. This study will elucidate important ancestry differences between Asian and Caucasian lung adenocarcinoma patients.

Official Title
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Comparative Genomic Profiling of Lung Adenocarcinoma in Asians and Caucasians: A Propensity Matched Analysis

Conditions
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Adenocarcinoma of Lung

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Primary lung adenocarcinoma Broad-panel next-generation sequencing Asian Exclusion Criteria: Inadequate clinicopathological information Low-quality next-generation sequencing

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Asian lung adenocarcinoma<br>Asian LUADs patients who had broad-panel next-generation sequencing (NGS) performed on their primary tumor between January 2018 and December 2019 at the department of thoracic surgery of Peking University People's Hospital | |
| Caucasian lung adenocarcinoma<br>Caucasian LUADs patients who had targeted NGS (Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets [MSK-IMPACT]) will be identified in the AACR GENIE database, which consists of 6673 primary lung adenocarcinoma samples with clinical annotations | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Oncoprint of somatic mutations | Association between genomic features and race | July 2021 | 
| Copy number variations (CNVs) | CNVs analysis by race | July 2021 | 
| Mutational signatures | Analysis of mutational signatures by race | August 2021 | 
| Oncogenic pathways | Analysis of oncogenic pathways by race | September 2021 | 
| Therapeutic actionability | Analysis of actionable alterations by race | October 2021 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Lung adenocarcinoma, Next-generation sequencing, Tumor genomic profiling, Ethnic differences