Determination of the Aneurysm Vulnerability Index by Stimulation and Medical Imaging

Study Overview
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Brief Summary
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Stroke is the leading cause of disability in France with 130,000 cases per year, 20% of strokes being hemorrhagic, with a majority of intracranial aneurysm rupture (80%). Each year, 6000 meningeal hemorrhages (MHA) caused by cerebral aneurysm rupture are reported in France: 40% of patients die within the first month and 30% are left with severe and permanent disability. Intracranial aneurysms are present in 2 to 6% of the population and only about 0.5% of them will rupture. Given the human and economic costs associated with this disease, systematic medical screening for intracranial aneurysms could be useful. However, the operative risk of endovascular treatment remains non-zero (around 1%) and could be proposed only to a selected population of aneurysms at risk of rupture. The absence of diagnostic criteria for aneurysmal vulnerability does not allow for the moment to consider screening for this disease, which continues to strike without warning a young and active population. Nevertheless, access to brain imaging allows the detection of an increasing number of intracranial aneurysms. The question of preventive treatment then arises and is still a difficult point discussed by neurosurgeons / neurointerventionists based on general epidemiological data difficult to apply to an individual.

Official Title
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Determination of the Aneurysm Vulnerability Index by Stimulation and Medical Imaging

Conditions
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Aneurysm

Intervention / Treatment
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* Other: Aneurysmal pulsation in functional MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age limits to > 18 years Collection of the informed consent (patient or legal representant) Affiliation or recipient with the mode of social security - Groupe anévrysme rompu Patient porteur d'un anévrysme rompu - Groupe anévrysme non rompu Patient porteur d'un anévrysme non rompu Exclusion Criteria: Subject presenting contraindications in MRI (Ferromagnetic foreign bodies, pace-maker …) Claustrophobia Women pregnant or Breast-feeding Patient participating in an other study Patient have participated in a study in the 3 months before the inclusion In period of exclusion relative to another protocol Person with majority age protected by the law (supervision or trusteeship). Patient not reading the french language Patient or representant for whom it impossible to give accurate informations

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Ruptured Cerebral Aneurysm<br>Quantify the aneurysmal pulsation in functional MRI on the patient with Ruptured Cerebral Aneurysm | Other: Aneurysmal pulsation in functional MRI<br>* Quantify the aneurysmal pulsation in functional MRI on the patient with Ruptured Cerebral Aneurysm<br>|
| Other: Non Ruptured Cerebral Aneurysm<br>Quantify the aneurysmal pulsation in functional MRI on the patient with Non Ruptured Cerebral Aneurysm | Other: Aneurysmal pulsation in functional MRI<br>* Quantify the aneurysmal pulsation in functional MRI on the patient with Ruptured Cerebral Aneurysm<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quantify the aneurysmal pulsation in functional MRI | Quantify the aneurysmal pulsation in functional MRI on the patient with Ruptured Cerebral Aneurysm or Non ruptured Aneurysm | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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aneurysm