The Influence of Porcelain Fused to Metal ( PFM) and Zirconia Crowns on Periodontal Health

Study Overview
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Brief Summary
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Investigate the influence of the crown tye Porcelain fused to metal or Zirconia on periodontal health.

Detailed Description
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Porcelain fused to metal (PFM) has been used in dentistry for the last five decades. Zirconia (zirconium oxide, ZrO2) is the white crystalline powder oxide of the naturally occurring metal zirconium. Research of the medical utilization of zirconia dates back to the late 1960s. However, its utilization in dentistry did not start until the 1990s, when zirconia began to be used as a form of endodontic posts and implant abutments. The current literature contains studies that investigated the influence of zirconia implants and abutments on periodontal tissue, but to the investigators' knowledge, no work has been yet published which compares the influences of crown types on hard and soft tissues. This prospective study will be conducted in the Department of Periodontology and in the Department of Maxillofacial Rehabilitation at Rambam Health Care Campus.

Official Title
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The Influence of Porcelain Fused to Metal ( PFM) and Zirconia Crowns on Periodontal Health

Conditions
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Periodontitis

Intervention / Treatment
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* Device: Zirconia crown
* Device: Porcelain metal crown


Participation Criteria
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Eligibility Criteria
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inclusion criteria: Patient age 18 - 85 years old In need for one or more fixed partial prosthetic crown or bridge exclusion criteria: Smokers Active periodontal disease history of compromising systemic disease Allergy to materials used in the study current drug abuse Pregnant or intend to become pregnant severe salivary gland dysfunction Severe medical complications ( organ transplants, cancer, immunocompromised, or undergoing long-term antibiotic or steroid therapy )

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Z Crown<br>A Zirconia crown will be provided to patients. | Device: Zirconia crown<br>* patients will receive a Zirconia crown, the Zirconia crown will cover the natural crown.<br>|
| Active Comparator: PFM Crown<br>A Porcelain metal crown will provided to patients. | Device: Porcelain metal crown<br>* patients will receive a porcelain fused to metal crown, the Porcelain metal crown will cover the natural crown.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PgE2 ( Prostaglandin E2) | Gingival cervicular fluid samples will be attempt be planning Periotrom paper in the mesial and distal aspect of the experimental teeth. This samples will be assayed for PgE2 ( Prostaglandin E2) using Elyza kit. The concentration of PGE2 in gingival crevicular fluid will be examined around each tooth receiving a crown. | 4 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PIaque index | The clinical examination will include measurement of PIaque index( soft tissue deposite around teeth) | 4 months | 
| GIingival index | The clinical examination will include measurement of the GIingival index (gingival inflamation around teeth) | 4 months | 
| Pocket depth | The clinical examination will include measurement of Pocket depth around teeth | 4 months | 
| Clinical attachment level | The clinical examination will include measurement of the Clinical attachment level around teeth | 4 months | 
| bone level | Periapical radiography will be obtain using customized film holding with Vinylpolysiloxan bite registration. Measurements of alveolar bone level will be performed on the digital images by a single examiner, using custom-made software. | 4 months |