Chinese Multi-provincial Cohort Study-Beijing Project

Study Overview
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Brief Summary
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The Chinese Multi-provincial Cohort Study (CMCS)-Beijing project is a sub-study in CMCS participants from Beijing, which intended to investigate the progression and determinants of atherosclerosis and aging related health problems through repeat examinations. Exam 0 to Exam 3 have been conducted during 1992 to 2012. Exam 4 is scheduled in 2020.

Official Title
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Chinese Multi-provincial Cohort Study-Beijing Project

Conditions
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Cardiovascular Diseases, Cardiovascular Risk Factor, Aging Problems, Smell Disorder, Sleep

Intervention / Treatment
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* Other: Cardiovascular risk factors
* Other: Aging related health problems


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participants from CMCS-Beijing sign the informed consent Exclusion Criteria: participanting in clinical trials

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Cardiovascular risk factors|Different level of cardiovascular risk factors, such as aging, hypertension, diabetes, dyslipidemia, smoke, alcohol drink, obesity and et al, associated with genetics, environments and lifestyles|
|Other: Aging related health problems|Aging related health problems|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| All fatal and nonfatal acute coronary and stroke events | Acute coronary heart disease events included acute myocardial infarction, sudden death, and other coronary deaths. Acute stroke events included subarachnoid hemorrhage, intracerebral hemorrhage, or cerebral infarction. | From date of enrollment until the date of first documented event or date of cardiovascular death, whichever came first, assessed at least 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| New-onset of coronary events | Acute coronary heart disease events included acute myocardial infarction, sudden death, and other coronary deaths. | From date of enrollment until the date of first documented event or date of CHD death, whichever came first, assessed at least 5 years | 
| New-onset of stroke | Acute stroke events included subarachnoid hemorrhage, intracerebral hemorrhage, or cerebral infarction. | From date of enrollment until the date of first documented event or date of stroke death, whichever came first, assessed at least 5 years | 
| Total death | All cause death | From date of enrollment until date of death from all cause, assessed at least 5 years | 
| Cognitive dysfunction | Cognitive dysfunction | From date of enrollment until date of first documented event, assessed at least 5 years | 
| Olfactory Disorders | Olfactory Disorders | From date of enrollment until date of first documented event, assessed at least 5 years | 
| Valvular disease | Valvular disease | From date of enrollment until the date of first documented event or date of valvular disease death, whichever came first, assessed at least 5 years |