Optimization of Preventive Effects of Physical Training

Study Overview
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Brief Summary
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Health-promoting effects of physical exercise are well-investigated especially for endurance activities. However, for different individuals, positive effects have different sizes, even non-responders are observed. Other forms of training, such as strength training and interval training, are less well investigated. Therefore, a comparative longitudinal training study is warranted to examine differences of preventive effects (outcome measures: ergometric descriptors of physical performance, established risk factors and prognostic factors for cardiovascular diseases) of continuous endurance training, interval training and strength endurance training. In a second stage, the observed non-responders will perform a different type of training (cross-over). It is expected, that besides a comparative general efficacy evaluation of the three training types, improved recommendations for optimized individualization of training parameters can be formulated.

Official Title
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Optimization of Preventive Effects of Physical Training Saarländische Ausdauer-Etappe (SAusE)

Conditions
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Primary Prevention, Cardiovascular Risk Factor Management, Size of Response to Training

Intervention / Treatment
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* Other: different training programs
* Other: control condition


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: untrained healthy non-smoking Exclusion Criteria: Contraindications for physical activity BMI > 30 kg/m2 resting blood pressure > 160/100 mmHg diabetes total cholesterol > 300 mg/dl maximal oxygen uptake > 50 ml/min/kg for men and > 45 ml/min/kg for women respectively other complaints or diseases that might interfere with exercise training

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Endurance training<br> | Other: different training programs<br>* two different endurance programs and one strength endurance program<br>|
| Experimental: interval training<br> | Other: different training programs<br>* two different endurance programs and one strength endurance program<br>|
| Experimental: strength endurance training<br> | Other: different training programs<br>* two different endurance programs and one strength endurance program<br>|
| Placebo Comparator: control<br> | Other: control condition<br>* unchanged lifestyle<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| VO2 max | determined during treadmill testing | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| resting heart rate |  | 6 months | 
| resting blood pressure |  | 6 months | 
| blood lipid profile | ratio: total cholesterol/HDL-cholesterol | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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primary prevention, endurance, cardiovascular risk factors, training, exercise, non-responder