Cryotherapy for Neuropathy in Children

Study Overview
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Brief Summary
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This study aimed to assess the efficacy of cryotherapy in controlling Peripheral Neuropathy in cancer children

Detailed Description
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Peripheral neuropathy is a serious condition characterized by symmetrical, distal damage to the peripheral nerves that may be caused by several classes of drugs, including chemotherapeutic agents. Chemotherapy-induced peripheral neuropathy (CIPN) is an adverse effect estimated to occur in up to 40% of patients undergoing chemotherapy, with its incidence increasing in patients being treated with multiple agents. Pharmacists play a pivotal role in the prevention and management of CIPN by recommending evidence-based pharmacologic and non pharmacologic strategies appropriate for the individual patient.Peripheral neuropathy (PN) is a systemic disease characterized by symmetrical, distal damage to the peripheral nerves that negatively impacts patient quality of life (QOL). Prolonged symptoms associated with PN can cause pain, interfere with functional ability (e.g., dressing, driving, house-work), and disrupt emotional health.

Official Title
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Effect of Cryotherapy in Controlling Peripheral Neuropathy in Cancer Children

Conditions
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Cancer

Intervention / Treatment
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* Other: Cryotherapy (apparatus)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Their age will ranging from eight to seventeen years. Children participated in this study will from both sexes. Children receiving chemotherapy as medical treatment protocol All children have polyneuropathy caused by chemotherapy. Exclusion Criteria: Children with Epilepsy. Children with blood clotting disorder. Children have Open wounds / broken skin Children with severe cardiac disease Uncooperative patients.

Ages Eligible for Study
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Minimum Age: 8 Years
Maximum Age: 17 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: They were assigned randomly into two equal groups.Group (A) study group received the same medical care and cryotherapy, three times / weak for three successful months. And group (B) control group received medical care and standard chemotherapy only.
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: the study group<br>Group (A) the study group received cryotherapy | Other: Cryotherapy (apparatus)<br>* Cryotherapy is a pain treatment that uses a method of localized freezing temperatures to deaden an irritated nerve. Cryotherapy is also used as a method of treating localized areas of some cancers (called cryosurgery), such as prostate cancer and to treat abnormal skin cells by dermatologists<br>|
| No Intervention: the control group<br>Group (B) the control group not received cryotherapy | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nerve conduction studies (NCS) | nerve conduction velocity for sensory ulnar nerve | nerve conduction velocity for sensory ulnar nerve at day 0 | 
| Nerve conduction studies (NCS) | nerve conduction velocity for sensory ulnar nerve | nerve conduction velocity for sensory ulnar nerve at day 90 | 
| Nerve conduction studies (NCS) | nerve conduction velocity for sensory median nerve | nerve conduction velocity for sensory sensory median nerve at day 0 | 
| Nerve conduction studies (NCS) | nerve conduction velocity for sensory median nerve | nerve conduction velocity for sensory sensory median nerve at day 90 | 
| Nerve conduction studies (NCS) | nerve conduction velocity for sensory sural nerve | nerve conduction velocity for sensory sural nerve at day 0 | 
| Nerve conduction studies (NCS) | nerve conduction velocity for sensory sural nerve | nerve conduction velocity for sensory sural nerve at day 90 | 
| Nerve conduction studies (NCS) | nerve conduction velocity for motor common peroneal nerve | nerve conduction velocity for motor common peroneal nerve at day 0 | 
| Nerve conduction studies (NCS) | nerve conduction velocity for motor common peroneal nerve | nerve conduction velocity for motor common peroneal nerve at day 90 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cancer, Peripheral neuropathy, Cryotherapy