Solanezumab Safety Study in Japanese Patients With Alzheimer's Disease

Study Overview
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Brief Summary
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The purpose of this study is to investigate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of multiple dosing Solanezumab in subjects with mild-to-moderate AD in Japanese population.

Official Title
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Multiple-Dose Safety in Japanese Subjects With Mild-to-Moderate Alzheimer's Disease

Conditions
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Alzheimer's Disease

Intervention / Treatment
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* Drug: Solanezumab


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men or non-fertile women, at least 50 years of age.(Women who are not surgically sterilized must be post-menopausal for at least 1 year.) Patients with mild to moderate AD by following disease diagnostic criteria National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association (NINCDS/ADRDA) criteria Modified Hachinski Ischemia Scale score of ≦ 4 Folstein Mini-Mental State Examination (MMSE) score of 15 through 26 Geriatric Depression Scale (GDS) score of ≦ 10 on the staff-administered short form Exclusion Criteria: Patients who don't have a reliable caregiver who is in frequent contact with the patient, who will accompany the patient to the office and/or be available by telephone at designated times, and will monitor administration of prescribed medications. Patients who have an MRI or CT scan since the onset of symptoms of AD that is inconsistent with a diagnosis of AD. Patients who have received acetylcholinesterase inhibitors (AChEIs) or memantine for less than 4 months, or have less than 2 months of stable therapy on these treatments. Patients who have current serious or unstable illnesses including hepatic, renal, gastroenterologic, respiratory, cardiovascular (including ischemic heart disease), endocrinologic, neurologic (other than AD), psychiatric, immunologic, or hematologic disease and other conditions that, in the investigator or subinvestigator(s)'s opinion, could interfere with the analyses of safety and efficacy in this study. Patients who have a history within the last 5 years of a serious infectious disease affecting the brain (including neurosyphilis, meningitis, or encephalitis) or head trauma resulting in protracted loss of consciousness within the last 5 years, or multiple episodes of head trauma. Patients who have a history within the last 5 years of a primary or recurrent malignant disease with the exception of resected cutaneous squamous cell carcinoma in situ, basal cell carcinoma, cervical carcinoma in situ, or in situ prostate cancer with a normal PSA post-resection. Patients who have allergies to humanized monoclonal antibodies. Patients who have a history within the last 5 years of a primary or recurrent malignant disease with the exception of resected cutaneous squamous cell carcinoma in situ, basal cell carcinoma, cervical carcinoma in situ, or in situ prostate cancer with a normal PSA post-resection. Patients who have ECG abnormalities obtained that, in the opinion of the investigator, are clinically significant with regard to the subject's participation in the study, including QTc prolongation (Bazett's corrected QTc interval, QTcB; males >435 msec or females >455 msec) or abnormally wide QRS complexes (resulting from bundle-branch blocks, interventricular conduction delays, or pacemakers). Patients who have a current, required use or expected use of excluded drugs through the duration(These drugs include typical neuroleptics (antipsychotics). In addition, typical neuroleptics may not be taken within 4 weeks. Patients who are currently taking chronic medications that affect central nervous system (CNS) function, and are not dose-stabilized for at least 4 weeks. Patients who have a ventriculoperitoneal shunt or gamma globulin (IgG) therapy within the last year. Patients who have previously completed or withdrawn from this study or previous participation in any other study investigating active immunization against Aβ. Patients who have any contraindications for MRI studies, including claustrophobia, the presence of metal (ferromagnetic) implants, or cardiac pacemaker. Patients who weigh less than 40 kg.

Ages Eligible for Study
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Minimum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: QW<br>IV infusion of 400mg once each week for 2 months | Drug: Solanezumab<br> <br> * Other names: LY2062430;|
| Experimental: Q4W<br>IV infusion of 400mg once every four weeks for 2 months | Drug: Solanezumab<br> <br> * Other names: LY2062430;|
| Experimental: Q8W<br>IV infusion of 400mg once every eight weeks for 2 months | Drug: Solanezumab<br> <br> * Other names: LY2062430;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adverse events |  | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in the extended ADAS-Cog stand for Alzheimer's Disease Assessment Scale-Cognitive subscale |  | 6 months | 
| pharmacodynamic of Aβ1-40 and Aβ1-42 |  | 6 months | 
| Pharmacokinetics |  | 6 months |