Effects of Navigated Repetitive Transcranial Magnetic Stimulation According to Post-stroke Aphasia Types

Study Overview
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Brief Summary
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Repetitive transcranial magnetic stimulation induced virtual lesions for aphasia.

Detailed Description
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To evaluate the effect of navigated repetitive transcranial magnetic stimulation in subjects with aphasia after stroke.

Official Title
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Effects of Navigated Repetitive Transcranial Magnetic Stimulation According to Post-stroke Aphasia Types

Conditions
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To Healthy Volunteer, Virtual Lesions for Aphasia

Intervention / Treatment
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* Device: Repetitive magnetic stimulation to superior temporal gyrus
* Device: Repetitive magnetic stimulation to middle temporal gyrus
* Device: Repetitive magnetic stimulation (Sham)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: fluent in Korean older than 18 years old Exclusion Criteria: younger than 18 years old psychotic or psychiatric problems pregnant contraindications to MRI/fMRI uncooperative metalic implants, pacemaker or cochlear implants cannot perform outcome measure-related task known seizure history

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Middle temporal gyrus<br>Repetitive magnetic stimulation to middle temporal gyrus | Device: Repetitive magnetic stimulation to middle temporal gyrus<br>* Repetitive magnetic stimulation to middle temporal gyrus<br>* Other names: MagPro X100 magnetic stimulator;|
| Sham Comparator: Control group<br>Repetitive magnetic stimulation (Sham) | Device: Repetitive magnetic stimulation (Sham)<br>* Repetitive magnetic stimulation (Sham)<br>* Other names: MagPro X100 magnetic stimulator;|
| Experimental: Superior temporal gyrus<br>Repetitive magnetic stimulation to superior temporal gyrus | Device: Repetitive magnetic stimulation to superior temporal gyrus<br>* Repetitive magnetic stimulation to superior temporal gyrus<br>* Other names: MagPro X100 magnetic stimulator;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The Change of Reaction Time Between Before and After Stimulation in Each Session (MTG, STG, Sham) | Reaction time for lexical and repetition test were measured before and after the TMS stimulation at each sessions (at session 1, session 2, session 3 over MTG/STG/Sham; MTG: middle temporal gyrus, STG: superior temporal gyrus). Response times were measured via the response pad, and spoken responses were recorded via a SV-1 Voice Key apparatus. The reaction time post TMS - reaction time pre TMS were used for analysis.* Arm/Group Title Arm/Group Description Maximum length (999) Repetitive magnetic stimulation (rTMS) were applied over STG | change between before and after the TMS stimulation for each sessions (at session 1, session 2, session 3) |