Heart Rate Variability and Hyperthyroidism: Evaluation of the Short-term Effects of Propanolol

Study Overview
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Brief Summary
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Objective: The aim of our study was to evaluate the short term effects of Propanolol on heart rate variability in patients with hyperthyroidism. Design: In ten patients newly diagnosed as having hyperthyroidism and naïve of all treatment specific for hyperthyroidism, we evaluated the short term effects of Propanolol on heart rate variability (HRV). Methods: We measured heart rate variability by power spectral analysis during 2 hours of rest and during Ewing's tests before and after the administration of Propanolol 40mg/12 hours orally for 72 hours.

Detailed Description
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Objective: The aim of our study was to evaluate the short term effects of Propanolol on heart rate variability in patients with hyperthyroidism. Design: In ten patients newly diagnosed as having hyperthyroidism and naïve of all treatment specific for hyperthyroidism, we evaluated the short term effects of Propanolol on heart rate variability (HRV). Methods: We measured heart rate variability by power spectral analysis during 2 hours of rest and during Ewing's tests before and after the administration of Propanolol 40mg/12 hours orally for 72 hours. Other outcomes included mean heart rate, mean R-R interval during 2-hour rest. The study questions the systematic adjunction of Propanolol early in the treatment of hyperthyroidism.

Official Title
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Short Term Effects of Propanolol on Heart Rate Variability of Hyperthyroidism

Conditions
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Hyperthyroidism

Intervention / Treatment
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* Drug: Propanolol


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: consenting patients referred to or diagnosed at the National Centre of Obesity of the Yaounde Central Hospital as having hyperthyroidism naïve of all treatment specific for hyperthyroidism. aged 18-70 years Exclusion Criteria: Patients already under a specific treatment for hyperthyroidism Patients taking beta blockers or any other cardiospecific treatment Patients presenting complications including acute thyrotoxic crisis, or symptomatic cardiac failure Contraindications to the prescription of beta blockers

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: Open label Before and After design
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention<br>72-hour propanolol before specific treatment of hyperthyroidism | Drug: Propanolol<br>* 72-hour propanolol before specific treatment of hyperthyroidism<br>* Other names: Avlocardyl;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart rate variability | Sympatho vagal tone measures | 72 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart rate | Heart rate | 72 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hyperthyroidism, heart rate variability, propanolol, Africa