linjc16/ctgov huggingface dataset:
Dorothy P. and Richard P. Simmons Center for ILD Research Registry

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to place past, current, and future medical record information into the UPMC Simmons Center for Interstitial Lung Disease Research Registry.

Detailed Description
-----------------
This study gives participant's permission to allow the staff at the Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease to to place past, current, and future medical record information into a UPMC Simmons Center for Interstitial Lung Disease Research Registry. By placing the medical record information of many patients into a research registry, researchers will be able to conduct research studies directed at increasing our knowledge about interstitial lung disease. It is anticipated that the research registry will assist out investigators by allowing researchers to review and study the medical records of many individuals to answer questions about interstitial lung disease and its treatment. In addition, it will help researchers identify and recruit patients for participation in future research studies.

Official Title
-----------------
Dorothy P. and Richard P Simmons Center for Interstitial Lung Disease Research Registry

Conditions
-----------------
Lung Diseases, Interstitial

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult patients who are seeking treatment at the UPMC Simmons Center for Interstitial Lung Disease 18 years of age or older Exclusion Criteria: N/A

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Lung[A04.400]
Risk Factors of Postoperative Acute Lung Injury Following Liver Transplantation

Study Overview
=================
Brief Summary
-----------------
Postoperative acute lung injury (ALI) during the first 72 hours after liver transplantation is not uncommon. Injury may occur because liver transplantation is often associated with prolonged operative time, large volumes of fluid administration and transfusion, as well as inflammatory responses related to ischemia-reperfusion injury. For more precise perioperative fluid and hemodynamic management, modern monitoring systems, such as the pulse contour cardiac output (PiCCO) system, have been devised and reported in recent years. The PiCCO system uses the thermodilution technique to determine the cardiac index (CI) and thoracic fluid indices such as the intrathoracic blood volume index (ITBVI), extravascular lung water index (EVLWI), and pulmonary vascular permeability index (PVPI), all of which may reflect pulmonary fluid and injury status. However, perioperative changes in thoracic fluid indices in liver transplantation and their associations with postoperative ALI are not yet clear. In this study, the investigators aimed to determine patterns of change in perioperative thoracic fluid indices and compare these changes in recipients who did or did not develop postoperative ALI. Furthermore, the investigators will also try to determine the potential risk factors following liver transplantation.

Official Title
-----------------
Risk Factors of Postoperative Acute Lung Injury Following Liver Transplantation

Conditions
-----------------
Acute Lung Injury

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: End stage liver disease receiving liver transplantation in NTUH. Age: 6 months old to 75 years old Exclusion Criteria: history of pulmonary resection, chronic respiratory insufficiency cardiac dysfunction failure of the surgery.

Ages Eligible for Study
-----------------
Minimum Age: 6 Months
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Acute lung injury<br>Postoperative acute lung injury was diagnosed according to the latest 2012 Berlin definition of acute respiratory distress syndrome by the PaO2/FiO2< 300 and acute onset of bilateral infiltrates on the chest radiograph that were not fully explained by cardiac failure during postoperative day 1 to postoperative day 3. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative acute lung injury |  | 72 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Extravascular lung water, Pulmonary vascualr permeability index, Liver transplantation
Fetal and Maternal Head Circumference During Pregnancy in Israeli Population

Study Overview
=================
Brief Summary
-----------------
In this study, measurements of fetal and maternal head circumference will be collected. This data will be presented in table or graph form. The effect of maternal head circumference on fetal head circumference will be evaluated and presented in either formula or graph form.

Official Title
-----------------
Fetal and Maternal Head Circumference During Pregnancy

Conditions
-----------------
Maternal-Fetal Relations, Microcephaly

Intervention / Treatment
-----------------
* Other: no intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Singleton pregnancy Valid first trimester sonogram Exclusion Criteria: Women under 18 years of age Women over 40 years of age Multi fetal pregnancy No accurate dating of pregnancy age Participant non compliance or cannot complete contact details Technical difficulty measuring fetal or maternal skull Abnormal fetal or maternal skull Familial hereditary disease, mental retardation Chronic maternal illness Maternal on chronic medication Abnormal screening test during current pregnancy Abnormal sugar metabolism or Hypertension during current pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: no intervention|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fetal head circumference (millimeters) | Israeli fetal population. Will be reported in table and / or graph form | 14 through 40 weeks pregnancy | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Relationship of fetal head circumference (mm) to maternal head circumference (mm) | Calculating effect of maternal head circumference on fetal head circumference during pregnancy and adjusting (Formula) fetal head circumference normal values (+/- 2SD) | 14 through 40 weeks pregnancy where applicable | 
| Maternal head circumference (millimeters) | Israeli maternal population. Will be reported in table and / or graph form | age 18 through 40 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Fetus, Skull, ultrasonography
Microcirculatory Assessment in Patients With Trauma and Severe Burns

Study Overview
=================
Brief Summary
-----------------
Predict the development of multiple organ failure in patients with trauma and severe burns.

Detailed Description
-----------------
Microvascular alterations are frequently seen in patients with sepsis, trauma, burns and those who are hemodynamically uncompensated(Shock). The use of the Microscan is a non-invasive approach to visualize and assess impaired mucosal microcirculation in order to identify early on patients who are predisposed for MOF (multiple organ failure)

Official Title
-----------------
Microcirculatory Assessment in Patients With Trauma and Severe Burns

Conditions
-----------------
Burns, Trauma

Intervention / Treatment
-----------------
* Other: micro-imaging


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with severe burns/trauma ages 19-80. Patients undergoing elective abdominal or cardiothoracic surgery ages 19-69 years old Exclusion Criteria: Patients undergoing elective surgery < 19 years old.

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: micro-imaging<br>Sublingual or subconjunctival micro-imaging of the microcirculation taken for 3 minute intervals at certain timepoints. Timepoints for burn/trauma subjects: Day0, Day1,Day2,Day6 & Day7 Timepoints for general surgery population: post-induction, prior to resection, after resection,& closing of surgical wound. | Other: micro-imaging<br>* micro-imaging<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| dysfunctional capillary density correlates with development of multiple organ failure |  | approximately 1 year to assess outcome measure | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
trauma, multiple organ dysfunction syndrome
Pain Map DK: a Prospective Cohort Study of Pain Treatment in 500 Hip Arthroplasty Patients at Different Danish Hospitals

Study Overview
=================
Brief Summary
-----------------
This is a prospective observational cohorte study. The aim is to investigate actual pain treatment and outcomes in a large population of total hip arthroplasty patients at 5 different hospitals in Denmark.

Conditions
-----------------
Postoperative Pain

Intervention / Treatment
-----------------
* Drug: Pain treatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Primary planned total hip arthroplasty, Able to understand and speak english or danish. Exclusion Criteria: patients not able to cooperate, patients with alcohol or drug abuse

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Frederiksberg Hospital<br>100 patients undergoing planned total hil arthroplasty | Drug: Pain treatment<br>* Registration af actual analgesic treatment and outcomes<br>|
| Koege hospital<br>100 patients undergoing planned total hil arthroplasty | Drug: Pain treatment<br>* Registration af actual analgesic treatment and outcomes<br>|
| Naestved Hospital<br>100 patients undergoing planned total hil arthroplasty | Drug: Pain treatment<br>* Registration af actual analgesic treatment and outcomes<br>|
| Hilleroed Hospital<br>100 patients undergoing planned total hil arthroplasty | Drug: Pain treatment<br>* Registration af actual analgesic treatment and outcomes<br>|
| Nykoebing Falster Hospital<br>100 patients undergoing planned total hil arthroplasty | Drug: Pain treatment<br>* Registration af actual analgesic treatment and outcomes<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| NRS pain during mobilization |  | 6 hours postoperatively | 
| Total morphine-eqv. opioid consumption |  | 24 hours postoperatively | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| NRS pain at rest |  | 6 hours postoperatively | 
| NRS pain at rest |  | 24 hours postoperatively | 
| NRS pain during mobilization |  | 24 hours postoperatively | 
| Nausea |  | 6 hours postoperatively | 
| Nausea |  | 24 hours postoperatively | 
| Vomiting |  | Number of episodes during 24 hours postoperatively | 
| Dizziness |  | 6 hours postoperatively | 
| Dizziness |  | 24 hours postoperatively | 
| Sedation |  | 6 hours postoperatively | 
| Sedation |  | 24 hours postoperatively | 
| Length of hospital stay |  | Number of days until discharge | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
postoperative pain treatment
Effects of Individualized Exercise Training in Patients With Peripheral Arterial Disease

Study Overview
=================
Brief Summary
-----------------
The study is designed to investigate individualized exercise training effects on arterial function, walking ability and quality of life in subjects with peripheral arterial disease post surgery.

Official Title
-----------------
Effects of Individualized Exercise Training on Arterial Function, Walking Ability and Quality of Life in Patients With Peripheral Arterial Disease Post Surgery

Conditions
-----------------
Peripheral Arterial Disease

Intervention / Treatment
-----------------
* Other: individualized exercise training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Peripheral arterial disease post surgery > 1 month No discharge of surgical incision Intermittent claudication post invasive treatment Exclusion Criteria: Necrosis Above/below knee amputee Other conditions might affect peripheral vascular elasticity

Ages Eligible for Study
-----------------
Minimum Age: 30 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: exercise<br> | Other: individualized exercise training<br>* Lower extremities resistance exercise and bicycle training<br>* Other names: exercise;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| arterial function, walking ability and quality of life |  | 12 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Peripheral Arterial Disease, Walking ability, Quality of life, Exercise training
Comparing the Shape and Frequency of Uterine Contractions

Study Overview
=================
Brief Summary
-----------------
Dystocia is the most common indication for primary cesarean section. The most common cause of dystocia is uterine dysfunction. In all cephalopelvic disproportion studies, more attention is usually paid on fetus and pelvic rather than on the role of uterine contraction in delivery. So we decided to determine the relationship between dystocia and uterine contraction patterns.

Official Title
-----------------
Principle Investigator

Conditions
-----------------
Uterine Contractions, Delivery

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age 18-35 years singleton pregnancy with cephalic term presentation tendency to do vaginal delivery having no medical or mental diseases having no pregnancy complications Intact membranes BMI<26 Exclusion Criteria: using oxytocin before and during the monitoring of contractions performing cesarean section for any reason except arrested delivery or pelvic constriction the birth weight< 2500 or >4000 using the analgesia such as epidural anesthesia morphine and pethidine during the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| the shape and frequency of uterine contractions in delivery<br>Uterine contractions were recorded by using fetal monitoring system (Model FC1400) at the beginning of the active phase (cervical dilatation 3-4 cm) for 30 min in two groups. | |
| the shape and frequency of uterine contractions in cesarean<br>Uterine contractions were recorded by using fetal monitoring system (Model FC1400) at the beginning of the active phase (cervical dilatation 3-4 cm) for 30 min in two groups. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the shape and frequency of uterine contractions | Uterus contractions were recorded using electronic fetal monitoring at the beginning of the active phase of labor (dilatation 3-5 cm) for 30 min. | up to 15 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Uterine contraction;, Shape; Frequency;, First stage labor;, Fall, Rise ratio.
Efficacy of Two Yogurt Formulations in Healthy Humans

Study Overview
=================
Brief Summary
-----------------
This study is to evaluate the safety and efficacy of consumption of: L.Ruteri containing yogurt, L.Fermentum containing yogurt VERSUS placebo on plasma lipids, as well as gastrointestinal microflora distribution in hyperlipidemic individuals.

Official Title
-----------------
Efficacy of Two Yogurt Formulations as Health Promoting Agents in Healthy Humans

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Dietary Supplement: L. Amylovorus
* Dietary Supplement: L. Fermentum


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy males and females aged 18-60 yr plasma LDL-C 130-260 mg/dl TG levels below 400 mg/dl body mass index (BMI) rangewill be 22 to 32 kg/m2 permitted to take stable doses of thyroid hormone and anti hypertensive agents, as long as these are continued equivalently throughout the duration of study Exclusion Criteria: history of recent (i.e. less than 3 mo) or chronic use of oral hypolipidemic therapy, including fish oils, or probucol within the last 6 mo, - history of chronic use of alcohol (>2 drinks/d), systemic antibodies, corticosteroids, androgens, or phenytoin, myocardial infarction, coronary artery bypass, or other major surgical procedures within the last six months recent onset of angina, congestive heart failure, inflammatory bowel disease, pancreatitis, diabetes, lactose intolerance or significant current (ie. onset within past three months) gastrointestinal, renal, pulmonary, hepatic or biliary disease, or cancer (evidence of active lesions, chemotherapy or surgery in the past year chronic user of probiotics, fiber laxative (greater than 2 doses/wk), or stimulant laxatives or has a history of eating disorders, exercise greater than 15 miles/wk or 4,000 kcal/wk.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: L. Amylovorus<br> | Dietary Supplement: L. Amylovorus<br>* L. Amylovorus<br>|
| Experimental: L. Fermentum<br> | Dietary Supplement: L. Fermentum<br>* L. Fermentum<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cholesterol Metabolism |  | 1 month |
Cesarean Scar Defect (CSD); Prevalence, Risk Factors And Possible Associated Symptoms

Study Overview
=================
Brief Summary
-----------------
The study aims to detect the incidence of Cesarean Scar Defect (CSD) in women undergoing CS in Women Health Hospital (WHH), assiut University, to identify risk factors for development of CSD and identify the possible gynaecological symptoms related to CSD.

Detailed Description
-----------------
All eligible women, who will undergo CS in Women Health Hospital (WHH) will be seen on regular visits to detect the presence of CSD by ultrasound and identify its characters and a questionnaire will be fulfilled by the candidates about the gynecological symptoms related to CSD and appeared after CS.

Official Title
-----------------
Cesarean Scar Defect (CSD); Prevalence, Risk Factors And Possible Associated Symptoms: A Cohort Observational Study

Conditions
-----------------
Cesarean Section Complications

Intervention / Treatment
-----------------
* Other: Two dimension and three dimension ultrasound


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All women who will undergo transverse lower segment cesarean section after 28 weeks gestational age (electively and Emergency), after counseling and written consent Exclusion Criteria: Rupture uterus (unscarred or scarred). Upper segment CS. Vertical lower segment CS.
Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Two dimension and three dimension ultrasound|Patient will undergo 2D and 3D ultrasound evaluation after CS for detection of CSD|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the incidence of CSD in Women health Hospital | the incidence of CSD in Women health Hospital | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
niche