Clinical Features and Outcomes of CBP Versus Non-CBP in Septic Children

Study Overview
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Brief Summary
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The effect of continuous blood purification (CBP) in children is unclear. Also, the timing of early application is still being explored. In this study, we need to explore the efficacy and the timing of application of CBP in children with sepsis or septic shock.

Detailed Description
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Early intervention of CBP can remove inflammatory factors in patients with sepsis and reduce the damage of inflammatory factors to organs; at the same time, it can also promote the body's immune response, significantly improve immune dysfunction, and restore the body's immune balance. However, the timing of early application of CBP in childhood sepsis is still unclear. Therefore, it is necessary to further explore the treatment and prognosis of this technology in the early treatment of sepsis.

Official Title
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Clinical Features and Outcomes of Continuous Blood Purification Versus Non-continuous Blood Purification in Pediatric Patients With Sepsis or Septic Shock

Conditions
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Sepsis, Children, Only

Intervention / Treatment
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* Procedure: CBP


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age of 29d to 18 years old; Children diagnosed with sepsis requiring blood purification. Exclusion Criteria: with a history of a duration of PICU stay <24 h active bleeding, including cerebral hemorrhage

Ages Eligible for Study
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Minimum Age: 28 Days
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| sepsis group with CBP<br>The child with sepsis should be treated with CBP， but could not receive this treatment for various reasons | Procedure: CBP<br>* continuous blood purification can prevent or treat fluid overload in children with septic shock or other sepsis-associated organ dysfunction who are unresponsive to fluid restriction and diuretic therapy management of septic AKI patients, particularly those with hemodynamic instability or fluid overload. Also, it can remove cytokines<br>* Other names: traditional therapy;|
| sepsis group without CBP<br>The child with sepsis should be treated with CBP and received this treatment | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| survival rate | The survival rate of children in 28 days after hospital discharge | 28 days after hospital discharge | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The creatinine level of non-survival children with sepsis | The creatinine level of non-survival children with sepsis in 28 days after hospital discharge | 28 days after hospital discharge | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Continuous renal replacement therapy, sepsis, timing