Pro-inflammatory Cytokines in Blood From Orthopedic Surgery Compared to Abdominal Aneurysm Repair

Study Overview
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Brief Summary
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The purpose of this study is to investigate the contents in blood sampled from surgery site during hip replacement compared with blood sampled from abdominal aortic surgery. Is there any difference in pro-inflammatory cytokines (IL-1beta, IL-6, IL-8 and TNF-α), complement activation (C3a)?

Detailed Description
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Patient (n= 10) scheduled for total hip replacement or hemiprosthesis and patient (n=10) scheduled for abdominal aortic surgery. Primary outcome: Pro-inflammatory cytokines (IL-6, IL-8 and TNF-α) and complement activation (C3a) in blood samples collected from surgery field. Comparison between the 2 groups. Secondary outcome: Haemoglobin, Trc, INR in blood samples and plasma will be analysed and compared between the 2 groups.

Official Title
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Pro-inflammatory Cytokines (IL-1beta,IL-6, IL-8 and TNF-α) and Complement Activation (C3a) in Blood Collected From Surgery Field From Patients Undergoing Orthopedic Surgery Compared to Patients Undergoing Abdominal Aneurysm Repair.

Conditions
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Aortic Diseases, Osteoarthritis, Hip

Intervention / Treatment
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* Device: Sangvia blood sampling system


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA 1-4 Exclusion Criteria: Patient using corticosteroids, NSAIDs or Cox-II inhibitors Patients under 18 years Patients who are included in pharmaceutical studies Opioids-, benzodiazepines-, antiepileptic drugs-, alcohol- and α2-agonists abuse Pregnant and breastfeeding women Patients with known hypersensitivity for opioids, propofol or volatile anesthetics Patients with serious arrhythmias (atrial fibrillation/flutter is acceptable) Uncontrolled hypertension, serious psychiatric disease Patients with unstable angina pectoris or myocardial infarction the last month before inclusion Acute abdominal aortic surgery (acute dissection or rupture) Planned laparoscopic abdominal aortic aneurysm surgery Transfusion of blood products last month before surgery Glucocorticoid users

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1/10<br>Abdominal aortic surgery patients | Device: Sangvia blood sampling system<br>* Blood collected from abdominal aortic repair patients are compared against blood collected from total hip replacement patients<br>* Other names: Sangvia Blood Salvage System;|
| 2/10<br>Total hip replacement patients | Device: Sangvia blood sampling system<br>* Blood collected from abdominal aortic repair patients are compared against blood collected from total hip replacement patients<br>* Other names: Sangvia Blood Salvage System;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pro-inflammatory cytokines (IL-6, IL-8 and TNF-α) and complement activation (C3a) in blood samples collected from surgery field. Comparison between the 2 groups. |  | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Haemoglobin, Trc, INR in blood samples and plasma will be analysed and compared between the 2 groups. |  | 30 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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aorta, disease, abdominal, surgery, Osteoarthritis, Hip, replacement, blood, autolog, transfusion, cytokines