Aging Brain Structure and Memory in Response to Exercise

Study Overview
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Brief Summary
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This study will measure brain structure through its mechanical properties, assessed with magnetic resonance elastography, and determine whether it improves with aerobic exercise in older adults with low memory abilities. Additionally, this study will determine if memory abilities improve with exercise and if they are related to brain structure. Overall, this project has the potential to identify how brain health is impacted by exercise in older adults.

Detailed Description
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Mechanical properties of the human brain, measured with magnetic resonance elastography (MRE), reflect the health of brain tissue. Our previous research has shown that these mechanical properties of the hippocampus are highly sensitive to memory function in young adults. Based on these findings, we believe that these mechanical properties may be strong indicators of memory health in older adults and populations experiencing decline in memory function (i.e. mild cognitive impairment, MCI). Further, our results indicate these properties and associated functions are positively impacted by fitness and exercise training, thus making them potentially ideal markers for brain health in assessing rehabilitation. The objective of this research is to examine these properties in older adults with and without MCI. We will do the following: (1) determine if there are differences in mechanical properties of memory systems in older adults with and without MCI; (2) establish structure-function relationships between mechanical properties and memory performance in the older adult population; and (3) determine if both mechanical properties and memory performance are impacted by cardiovascular health, both through cross-sectional assessment of aerobic fitness and longitudinal response to exercise training.

Official Title
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Mechanical Integrity of Memory Systems in Mild Cognitive Impairment

Conditions
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Mild Cognitive Impairment

Intervention / Treatment
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* Behavioral: Aerobic exercise
* Behavioral: Stretching


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Cognitive function scores consistent with amnestic mild cognitive impairment based on pre-screening evaluation age 60-90 years MMSE score >24 at time of initial consent Exclusion Criteria: major psychiatric disorder (e.g. schizophrenia, bipolar disorder, major depression within past two years) neurological or autoimmune conditions affecting cognition (e.g. Parkinson's disease, epilepsy, multiple sclerosis, head trauma with loss of consciousness greater than 30 min, large vessel infarct) other systemic medical illnesses (e.g. cardiovascular disease, cancer, renal failure, diabetes, chronic obstructive pulmonary disease, liver diseases, hypertension) current medication use likely to affect CNS functions (e.g. long active benzodiazepines) failed outcome on the baseline graded exercise test hypertension (systolic 130+ mmHg OR diastolic 80+ mmHg) from baseline blood pressure measurement claustrophobia, metal implants, pacemaker or other factors affecting feasibility and/or safety of MRI scanning concussion within last 2 years and more than 3 lifetime concussions current smoking (including marijuana) within the past 3 months

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Aerobic exercise<br>Exercise training | Behavioral: Aerobic exercise<br>* Participants will complete 12 weeks of supervised aerobic exercise, 3 times per week, on a treadmill or stationary bicycle<br>|
| Active Comparator: Stretching<br>Control | Behavioral: Stretching<br>* Participants will complete 12 weeks of supervised stretching, 3 times per week<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in brain mechanical properties | Investigators are assessing change in brain structure through mechanical properties in response to exercise from baseline to the end of the 12 week program. An MRI scan with magnetic resonance elastography (MRE) will be used to measure properties of brain regions important to memory (e.g. hippocampus). | Baseline, 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in relational memory performance | Behavioral memory test will be used to assess relational memory through accuracy on a spatial reconstruction task. | Baseline, 12 weeks | 
| Change in cardiorespiratory fitness | Graded exercise test will measure cardiorespiratory fitness through volume of oxygen uptake (VO2) | Baseline, 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Exercise, Memory, Brain