Obesity-related Inflammation in Patients Prior to and After Bariatric Surgery

Study Overview
=================
Brief Summary
-----------------
This study investigates the chronic long-term health condition of obesity and its effect on neutrophil function and the inflammatory response

Detailed Description
-----------------
Inflammation is a central component of the immune response. In its acute form it aids the transition from disease to health via the activation of numerous immune cells, enabling them to reach the site of infection/injury and orchestrate themselves to combat pathogens, facilitating resolution and repair to restore the host to health. However, chronic inflammation is deleterious to the host and differs from the classical acute inflammatory process in that the inflammation is not necessarily so readily obvious and is not self-limiting; rather, the immune system is in a constant state of low-grade activation and when challenged by pathogenic or sterile injury the response is heightened, resulting in prolonged tissue damage and a failure of efficient resolution mechanisms. Neutrophils are important mediators of acquired innate immune responses but may also contribute to the pathogenesis of chronic inflammatory diseases. Neutrophils are heavily involved in antimicrobial defence; their primary role is the localisation and elimination of pathogenic microorganisms. This, combined with their relatively short lifespan, has resulted in a traditional view of them as limited kamikaze cells. However, as detailed here, neutrophils have been shown to act with complexity and sophistication, orchestrating the immune/inflammatory response but also inadvertently contributing to tissue damage in different disease states. This study investigates the chronic long-term health condition of obesity and its effect on neutrophil function and the inflammatory response

Official Title
-----------------
Obesity-related Inflammation in Patients Prior to and After Bariatric Surgery

Conditions
-----------------
Obesity, Morbid Obesity

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria for Bariatric participants: BMI >40 Undergoing Gastric Band surgery Exclusion Bariatric Participants Criteria: Undergoing alternative weight loss surgery BMI<40 Smoking Pregnancy Exclusion criteria for the controls BMI over 27 pregnancy smoking evidence of systemic disease use of medications/vitamin supplements.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with a BMI over 40<br>Participants were aged between 27-65 years, BMI >40 , Co-Morbidities associated with obesity including sleep apnoea, hypertension, depression, hypercholesterolaemia and type 2 diabetes, Undergoing Gastric Band surgery | |
| Lean, healthy individuals<br>Participants were aged between 27-65 years, BMI<28 , Systemically healthy, taking no prescribed medication | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Biochemical Markers associated with Inflamation | (IL-8, IL-1, ROS, Production of NETS) | OCT 2016 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
gastric bypass, Obesity, Morbid obesity, Matched Healthy Controls