Study on Yangxue Nao Granules Reducing the Risk of Stroke

Study Overview
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Brief Summary
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Objective: To explore the effectiveness of raising serum nao granules in reducing the risk of bleeding in patients with acute ischemic stroke treated with intravenous thrombolysis in the real world

Detailed Description
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Objective: To explore the effectiveness of raising serum nao granules in reducing the risk of bleeding in patients with acute ischemic stroke treated with intravenous thrombolysis in the real world Study Design. This study was a single center real world study. Through the review data, this study included in January 1, 2017 to September 30, 2019, see a doctor at Peking University third hospital neurology, emergency diagnosis of acute ischemic stroke, and venous thrombolysis in patients with a queue, on the basis of whether the application have serum brain particles are divided into a group and the control group, serum application parameters and nonparametric comparison, K-M curve and Cox regression model were used to evaluate the effectiveness of Yangxuenao granules in reducing bleeding conversion after intravenous thrombolysis by comparing the number of microbleeding, stroke severity score and modified Rankin score after 3 months follow-up with the weighted craniocerebral magnetic sensitivity imaging sequence reexamined within 48 hours.

Official Title
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A Real World Study of Yangxuenao Granules Reducing Bleeding Risk in Patients With Acute Ischemic Stroke Treated With Intravenous Thrombolysis

Conditions
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Cerebral Infarction

Intervention / Treatment
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* Drug: Raise serum brain granules
* Drug: No nourishing serum brain granules are used


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: A cohort of patients admitted to the Department of Emergency Neurology at Peking University Third Hospital on January 1, 2017 and admitted on September 30, 2019, who were diagnosed with acute ischemic stroke and underwent intravenous thrombolysis. Exclusion Criteria: Patients who underwent intravenous thrombolysis but were confirmed to be apoplexy like by imaging and other clinical examinations; Incomplete craniocerebral MRI examination; Bridging endovascular therapy; The previous application of Yangxuenao granules or other drugs with similar effects;
Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| The experimental group<br>The application of raising serum brain granules | Drug: Raise serum brain granules<br>* Should Yangseronao granules be used in patients undergoing intravenous thrombolysis for the diagnosis of acute ischemic stroke<br>|
| The control group<br>No nourishing serum brain granules are used | Drug: No nourishing serum brain granules are used<br>* No nourishing serum brain granules are used<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Microhemorrhage (CMB) of T2* sequence in MRI after thrombolysis | The number of CMB is an important imaging marker reflecting microvascular injury. | 1 day |