Effects of Whole Body Vibration on Autonomic Function in Healthy Young and Elderly

Study Overview
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Brief Summary
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Aging causes anatomical and physiological changes in the cardiovascular system and autonomic function with decline in its maximum function. This study aimed to evaluate the acute effects of whole body vibration on cardiovascular system, autonomic function and heart variability in healthy young and elderly. The investigators' hypothesis is that whole body vibration has different effects in young and elderly.

Official Title
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Acute Effects of Whole Body Vibration on Autonomic Function in Healthy Young and Elderly

Conditions
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Healthy, Aging

Intervention / Treatment
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* Other: Whole Body Vibration


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Elderly individuals aged between 60 and 80 years Young individuals aged between 18 and 30 years Able to walk without assistance Good understanding to perform the proposed procedures Sedentary or low active Exclusion Criteria: Body Mass Index (BMI) > 35Kg/m2 Systolic blood pressure > 140 mmHg or diastolic blood pressure > 90 mmHg (at rest) Difficulty adapting to the whole body vibration Smoking Neuromuscular or degenerative disorders Neurological diseases Cardiopulmonary comorbidities Cardiac arrhythmias Osteoarticular disorders Use of hormone replacement therapy Use medications or supplements known to affect cardiovascular parameters Labyrinthitis

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Young Group<br>Healthy young of both sexes between the ages of 18 and 30 years will perform a whole body vibration session | Other: Whole Body Vibration<br>* A whole body vibration session will be performed through a vibrating platform with three axes and vibration frequency set at 35 Hz. The amplitude used will be 04 mm.<br>|
| Experimental: Elderly Group<br>Healthy elderly of both sexes between the ages of 60 and 80 years will perform a whole body vibration session | Other: Whole Body Vibration<br>* A whole body vibration session will be performed through a vibrating platform with three axes and vibration frequency set at 35 Hz. The amplitude used will be 04 mm.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Autonomic Function | Heart rate variability will be assessed from 3-channel holter | Change from Baseline Heart rate variability at 5, 10, 15, 20 and 35 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sympathetic modulation | Sympathetic modulation will be assessed from 3-channel holter | Change from Baseline Sympathetic modulation at 5, 10, 15, 20 and 35 minutes | 
| Parasympathetic modulation | Parasympathetic modulation will be assessed from 3-channel holter | Change from Baseline Parasympathetic modulation at 5, 10, 15, 20 and 35 minutes | 
| Sympathovagal Balance | Sympathovagal Balance will be assessed from 3-channel holter | Change from Baseline Sympathovagal balance at 5, 10, 15, 20 and 35 minutes | 
| Heart Rate | Non-invasive measures will be assessed from 3-channel holter | Change from Baseline Heart Rate at 5, 10, 15, 20 and 35 minutes | 
| Blood pressure | Non-invasive measures of brachial blood pressure | Change from Baseline Blood pressure at 5, 10, 15, 20 and 35 minutes | 
| Peripheral oxygen saturation | Non-invasive measures will be assessed from pulse oximeter | Change from Baseline Peripheral oxygen saturation at 5, 10, 15, 20 and 35 minutes | 
| Adverse effects | Adverse effects reported by volunteers | Change from Baseline at 20 minutes |