Severity Index of Diquat Poisoning in Evaluating the Prognosis of Acute Diquat Poisoning

Study Overview
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Brief Summary
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Diquat (DQ) is a non-selective quick-acting bactericidal herbicide, which is the same bipyridine compound as paraquat (PQ).The number of patients with acute diquat poisoning is gradually increasing worldwide, and the mortality rate is not lower than that of paraquat (citing), but there is currently a lack of objective indicators to assess the severity or prognosis of diquat poisoning.By referring to SIPP ideas, the research team intends to establish a model that meets the clinical characteristics of diquat poisoning and effectively predicts the prognosis of patients, namely SIDP. In order to obtain an objective, accurate and relatively convenient method to judge the condition and prognosis of patients with acute diquat poisoning.

Detailed Description
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Objective - To develop and validate a set of practical prediction tools that reliably estimate the outcome of acute diquat poisoning（ADP）. Design - Cohort study with logistic regression analysis to combine predictors and treatment modality. Main outcome measure - The primary study outcome was death from any cause within 90 days after diquat ingestion. Goals- To develop a prediction models that reliably estimates the outcome of patients who were managed in various settings for acute diquat poisoning.

Official Title
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Development and Validation of Outcome Prediction Models for Acute Diquat Poisoning : a Cohort Study

Conditions
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Poisoning

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: all have a clear history of exposure to oral diquat solution; complete the toxicant test immediately after admission, and have certain initial blood drug concentration data; the clinical data is true and complete; the patients or family members are aware of and agree to the treatment plan. Exclusion Criteria: ingested two or more toxicants; diquat was not detected in the blood or urine and the patient has no relevant clinical symptoms; suffer from primary disease relative to heart, lung, liver, kidney and brain .

Ages Eligible for Study
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Minimum Age: 14 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| development set<br>50 cases are the development set, which is used to develop the prediction model of diquat acute poisoning. These patients are all from the First Affiliated Hospital of Nanjing Medical University. | |
| validation set<br>50 patients are the validation set, from more than ten tertiary a-level hospitals in the surrounding area, to verify the prediction model. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The primary study outcome was death from any cause within 90 days after diquat ingestion. | Through relevant clinical data, find the predictors of death group and survival group | 90 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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acute diquat poisoning, predication model