linjc16/ctgov huggingface dataset:
Cardiac Computed Tomography: Characteristics of Isolated Left Ventricular Non-compaction

Study Overview
=================
Brief Summary
-----------------
The diagnostic criteria for isolated left ventricular non-compaction cardiomyopathy (IVNC) have been well established for echocardiography and cardiac magnetic resonance, such validation is lacking for computed tomography (CT). Such criteria are of great clinical relevance as a growing number of patients undergo a cardiac CT scan in daily clinical routine. The investigators aim to test the diagnostic accuracy of cardiac CT in distinguishing IVNC from lesser degrees of trabecular layering seen in potential differential diagnoses such as cardiomyopathies and left ventricular hypertrophy or dilation. The investigators hypothesize that echocardiographic diagnosed pathological trabeculation can be distinguished by determining the ratio of non-compacted to compacted myocardium on cardiac CT.

Conditions
-----------------
Left Ventricular Noncompaction, Isolated Noncompaction of the Ventricular Myocardium

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Established diagnosis of IVNC or differential diagnosis Age: Men > 30 years, women > 50 years without menstruation for at least 2 month. Written informed consent to participate Exclusion criteria: Contraindication for cardiac CT Renal insufficiency (GFR < 60ml/min) Known allergy to iodinated contrast agent Known Hyperthyroidism Non-sinus rhythm Known premature ventricular or supraventricular beats Hypotension (systolic blood pressure < 100mmHg) Contraindication for CMR Implanted cardiac pacemaker or defibrillator Other implanted medical devices (e.g. implantable cardioverter-defibrillator) Claustrophobia Known premature ventricular or supraventricular beats Pregnancy Claustrophobia

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| IVNC<br> | |
| differential diagnosis to IVNC<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
isolated left ventricular non-compaction, cardiac computed tomography, cardiac magnet resonance imaging, echocardiography
Stroke and PMSI (Medicalisation Information Systems Programm)

Study Overview
=================
Brief Summary
-----------------
Evaluation of the sensitivity and specificity of PMSI to identify the burden of stroke in France,from 2500 cases

Official Title
-----------------
Stroke and PMSI Evaluation of the Sensitivity and Specificity

Conditions
-----------------
Stroke

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: diagnosis of stroke in the hospital activity board Exclusion Criteria: none

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| stroke<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Telephone Use for Care of Persons With Diabetes Mellitus.

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine whether phone use contributes to diabetes control.

Detailed Description
-----------------
Studies reinforce the need to test innovative care that can serve more patients, since education is a key element for the accession to the treatment of diabetes. Recently, an innovative, feasible and low cost presented in the literature is the use of telephone support as an intervention strategy This study aims to evaluate the implementation of a telephone support for self-monitoring of people with diabetes mellitus treated in ribeirão Preto.

Official Title
-----------------
Telephone Support for Self-monitoring of Persons With Diabetes Mellitus Using the Chronic Care Model

Conditions
-----------------
Diabetes Mellitus

Intervention / Treatment
-----------------
* Behavioral: telephone support


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: diabetes mellitus type 2 age ability to listen and answer questions Exclusion Criteria: often present less than 75% participation in the proposed activities

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Telephone support<br>Intervention type: Telephone support for four months. | Behavioral: telephone support<br>* Telephone support for four months about healthy diet, physical activity and medication use.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Telephone Support for self-monitoring of persons with diabetes mellitus using the Chronic Care Model |  | Four months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
nursing care, diabetes mellitus, phone support, chronic care model
INTACS (Intrastromal Corneal Ring Segments) For Corneal Ectasia

Study Overview
=================
Brief Summary
-----------------
To join established study put on by Addition Technologies, Inc. in the surgical implantation of asymmetrical INTACS segments to treat myopia and astigmatism in patients with keratoconus.

Detailed Description
-----------------
Use of asymmetrical corneal inserts to reduce or eliminate myopia and astigmatism in patients with keratoconus, who are no longer able to achieve adequate vision with their contact lenses or spectacles, so that their functional vision may be restored and the need for corneal transplantation may potentially be deferred.

Official Title
-----------------
INTACS (Intrastromal Corneal Ring Segments) For Corneal Ectasia

Conditions
-----------------
Keratoconus

Intervention / Treatment
-----------------
* Device: INTACS


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 21 years of age, or older have experienced a progressive deterioration in their vision, such that they can no longer achieve adequate functional vision on a daily basis with contact lenses, or spectacles. have clear central corneas have a corneal thickness of 450 microns or greater at the proposed incision site have corneal transplantation as the only remaining option to improve their visual function Exclusion Criteria: under 21 years of age have not experienced a progressive deterioration in their vision, such that they can no longer achieve adequate functional vision on a daily basis with contact lenses, or spectacles. do not have clear central corneas do not have a corneal thickness of 450 microns or greater at the proposed incision site do not have corneal transplantation as the only remaining option to improve their visual function

Ages Eligible for Study
-----------------
Minimum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Keratoconus<br> | Device: INTACS<br>* asymmetrical corneal inserts to reduce, or eliminate myopia and astigmatism in patients with keratoconus to decrease dependence on contact lenses and spectacle correction, while potentially deferring need for corneal transplantation.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Corneal mapping to measure corneal thickness and steepening | Corneal Topography | 1 year |
Development and Validation Phase of Diffusion Tensor Imaging and Arterial Spin Labelling at 3 Tesla Using a Long-term Effort Model Applicable to Skeletal Muscle Characterization.

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to demonstrate and quantify the micro architecture and micro vascular changes within skeletal muscles after marathon using 3T MRI (diffusion tensor and arterial spin labeling). Apparent diffusion coefficient, fractional anisotropy and flow parameters will be registered before and after the long-distance run on the lower leg. Axial T1 and axial SPAIR sequences will also be applied at the same time.Stress ox and inflammatory markers will be collected in blood and urine samples and compare with both MRI and Near-infrared spectroscopy (NIRS).

Conditions
-----------------
Marathoners

Intervention / Treatment
-----------------
* Device: Magnetic Resonance Imaging (MRI)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Realizing between 2:10 and 4:30 in the marathon. Exclusion Criteria: Smoker Subject with medical treatment or with a treatment interrupted for less than 30 days. Subject with a osteo-articular, cardiovascular, infectious, lung pathology and/or a metabolic chronic pathology. MRI Contraindication : Claustrophobic subject ; subject with a intra-cranial vascular clip, with a pacemaker, with a neurostimulator or a cochlear implant ; subject with intraocular metallic foreign bodies.

Ages Eligible for Study
-----------------
Minimum Age: 25 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Marathoners<br> | Device: Magnetic Resonance Imaging (MRI)<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fractional Anisotropy (FA) measure | The measures will be made from sequences echoplanar (EAR), and will be extracted by post-treatment software Siemens untitled  Syngo and FSL, allowing a distortions correction. | at 4 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Apparent Diffusion Coefficient (ADC) value |  | at 4 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Skeletal muscle, Marathon, MRI
The Impact of Pituitary-thyroid and Pituitary-adrenal Axes Function on COVID-19 Clinical Course.

Study Overview
=================
Brief Summary
-----------------
The main focus of the study is the assessment of hormonal function in the course of COVID-19 infection with special regard for trends predicting clinical events defined as primary endpoints of the study.

Official Title
-----------------
The Impact of Pituitary-thyroid and Pituitary-adrenal Axes Function on COVID-19 Clinical Course.

Conditions
-----------------
COVID-19, Low Triiodothyronine Syndrome, Adrenal Insufficiency, Subacute Thyroiditis, Hypothyroidism, Hyperthyroidism

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: PCR-confirmed COVID-19 infection volunteers consenting to participate Exclusion Criteria: no consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Meeting the primary endpoint criteria. | Primary endpoint is defined as a composite endpoint including death, mechanical ventilation, vasopressor use, noninvasive ventilation, prolonged hospital stay (>10 days). | Time of hospitalization, typically less than one month. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
COVID-19, thyroid, adrenal gland, pituitary, glucocorticoids
Macronutrients and Gut Hormone Secretion

Study Overview
=================
Brief Summary
-----------------
Study hypothesis is to examine the relative contribution of macronutrients for gut hormone secretion after a mixed meal in healthy volunteers and in subjects with type 2 diabetes. Individual macronutrients or a mixed meal will therefore be served and gut hormones are measured during the following 300 min.

Detailed Description
-----------------
In healthy volunteers and subjects with dietary regulated diabetes mellitus, glucose, protein mixture or fat emulsion will be served individually and on a separate occasions a mixed meal will be served. Samples will be taken during the following 300 min. Concentrations of the gut hormones glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1, insulin and glucagon will be determined.

Official Title
-----------------
Effects of Macronutrients on Gut Hormone and Islet Hormone Secretion in Healthy Volunteers and Type 2 Diabetes

Conditions
-----------------
Type 2 Diabetes

Intervention / Treatment
-----------------
* Other: Macronutrients


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy status or type 2 diabetes with dietary regulation Exclusion Criteria: Liver disease kidney disease thyroid disease

Ages Eligible for Study
-----------------
Minimum Age: 35 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Non-Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Type 2 diabetes<br>Administration of macronutrients in type 2 diabetes | Other: Macronutrients<br>* Glucose 330 kcal Protein 110 kcal Fat emulsion 110 kcal Mixed meal 550 kcal<br>* Other names: Mixed meal;|
| Experimental: Healthy volunteers<br>Administration of macronutrients in healthy volunteers | Other: Macronutrients<br>* Glucose 330 kcal Protein 110 kcal Fat emulsion 110 kcal Mixed meal 550 kcal<br>* Other names: Mixed meal;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Release of gut hormones |  | 300 min | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Insulin secretion |  | 300 min | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Gut hormones, Insulin secretion
Effect of Laparoscopic Ovarian Drilling on Outcomes of in Vitro Fertilisation in Clomiphene-resistant Women With Polycystic Ovary Syndrome

Study Overview
=================
Brief Summary
-----------------
the polycystic ovarian syndrome is associated with an ovulation and infertility. recently the laparoscopic ovarian drilling has been used as surgical treatment for ovulation in women with polycystic ovarian syndrome, although its mechanism and outcomes are still unclear. this study is undertaken to evaluate the in vitro fertilisation outcomes in clomiphene-resistant women with PCOS who were treated with LOD.

Official Title
-----------------
Effect of Laparoscopic Ovarian Drilling on the Outcomes of in Vitro Fertilisation in Clomiphene-resistant Women With Polycystic Ovary Syndrome

Conditions
-----------------
PCOS

Intervention / Treatment
-----------------
* Procedure: IVF/ICSI


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age between 25 and 35 patients with established PCOS history at least one year infertility no response to clomiphene citrate for at least three cycles Exclusion Criteria: history of previous IVF/ICSI chronic disease such as thyroid disorder and DM infertility due to sever male factor sever endometriosis infertility due to uterine factor such as multiple fibroid body mass index > 30

Ages Eligible for Study
-----------------
Minimum Age: 25 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: PCOS women with history of LOD before IVF/ICSI<br> | Procedure: IVF/ICSI<br>* IVF/ICSI<br>|
| Active Comparator: PCOS women without history of drilling<br> | Procedure: IVF/ICSI<br>* IVF/ICSI<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| clinical pregnancy rate confirmed by b-hcg and visualizations of gestational sac by ultrasound | Pregnancy confirmed by b-hcg and visualization of gestational sac by ultrasound | 3 months |
Persistence of Immune Response After Vaccination With MCC

Study Overview
=================
Brief Summary
-----------------
Persistence of Immune response after vaccination with MCC

Official Title
-----------------
A Phase IV, Single Centre, Open-label Study to Evaluate the Persistence of Antibodies in Adolescents 14-16 Years of Age, Vaccinated With Chiron Meningococcal C Conjugate Vaccine During the 1999-2001 UK MenCC Immunization Campaign, at One Year After Either a Challenge Dose of Aventis Pasteur MSD Meningococcal A/C Polysaccharide Vaccine or a Booster Dose of MenC Vaccine, in Parallel to Subjects Aged 11-20 Evaluated at 4 Years After Vaccination During the 1999-2001 UK MenCC Immunization Campaign

Conditions
-----------------
Prevention of Meningococcal Infection

Intervention / Treatment
-----------------
* Procedure: BLOOD DRAW


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy adolescents vaccinated with Meningococcal C Conjugate vaccine Exclusion Criteria: ascertained or suspected disease caused by N. meningitidis household contact with individuals with proven N. meningitidis serogroup C infection significant acute or chronic infections any other serious disease

Ages Eligible for Study
-----------------
Minimum Age: 11 Years
Maximum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: BLOOD DRAW|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| persistence of memory response to N. meningitidis serogroup C as measured by serum bactericidal activity at one year after either a challenge with 1/5 of a dose of Meningococcal A/C Polysaccharide vaccine or a booster dose of MenC Vaccine. |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation and comparison of the persistence of antibodies against N. meningitidis serogroup C as measured by hBCA |  |  | 
| Evaluation of the immunological response (ELISA) to N. meningitidis serogroup C |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Prevention of Meningococcal Meningitis, vaccines, conjugate, immunology, antibody persistence
Neurobiological Changes When Treating Depression With Electroconvulsive Therapy - a Longitudinal Observational Study

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine functional and structural changes in brain following treatment of severe depression with electroconvulsive therapy with correlation to clinical outcome. Our hypothesis is that there are state-dependent changes in functional connectivity within specific neurocircuits systems, as well as structural plasticity changes in hippocampus, when recovering from depression.

Detailed Description
-----------------
The study is a prospective, within-subject, observational follow-up study in individuals with depression who receive electroconvulsive therapy (ECT)at a psychiatric clinic. We will use a consecutive sampling method and patient referred for ECT by their psychiatrist will be screened for inclusion and asked for participation. Both in - and outpatients can be included. At three occasions (before treatment, after four week and after three months) patients will be assessed with clinical ratings, cognitive tests, functional and structural magnetic resonance imaging and biomarkers for cell proliferation.

Official Title
-----------------
Neurobiological Changes and Clinical Outcome When Treating Depression With Electroconvulsive Therapy.

Conditions
-----------------
Depression

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: major depressive disorder depressive episode in bipolar disorder age 18 - 65 years Exclusion Criteria: alcohol- and/or drug dependence or abuse in the past 3 months severe/life-threatening medical disease pregnancy type I diabetes neurodegenerative disorder inability to give written informed consent to participation in the study contradiction to MRI scanning.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Depression, ECT<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measures of hippocampal volume assessed by structural MRI |  | Three months | 
| fMRI BOLD resting state functional connectivity |  | 3 month | 
| fMRI BOLD responses during execution of emotional and reward processing tasks |  | 3 months | 
| Biomarkers of cell proliferation |  | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Relation between neurobiological changes and clinical and cognitive outcome |  | Three months |