Effect of Remote Ischemic Postcondioning on Glymphatic System in Acute Stroke

Study Overview
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Brief Summary
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Investigators aimed to investigate the changes of glymphatic function after remote ischemic postcondioning treatment in acute ischemic stroke .

Official Title
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Effect of Remote Ischemic Postcondioning on Glymphatic System in Acute Ischemic Stroke

Conditions
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Stroke

Intervention / Treatment
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* Procedure: remote ischemic postcondioning
* Drug: standard therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The patient was 18-80 years old; The NIHSS score was ≤ 25 and NIHSS > 5，Glasgow coma score ≥ 8; The patients were diagnosed as anterior circulation cerebral infarction and could start remote ischemic postcondioning within 24 hours after onset Normal to random time within 24 hours Written informed consent signed by patients or their families Exclusion criteria: patients receiving thrombolysis or endovascular therapy; modified Rankin scale (mRS) score ≥ 2 before this attack; other intracranial lesions, such as cerebral hemorrhage, cerebral venous disease, severe subclavian artery stenosis and other diseases involving the brain; Arterial blood pressure ≤ 90/60mmHg or ≥ 180/100mmHg after treatment.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: standard therapy<br>Patients will be treated with Guideline standard | Drug: standard therapy<br>* received standardized treatment<br>|
| Experimental: remote ischemic postcondioning and standard therapy<br>Patients will be treated with remote ischemic postcondioning and Guideline standard , remote ischemic postcondioning twice a day for a total of 3 days. | Procedure: remote ischemic postcondioning<br>* remote ischemic postcondioning twice daily, for three consecutive days，the upper arm of the lighter paralyzed side was pressurized to 200mmHg, pressurized 5min and relaxed for 5 minutes for 4 cycles as a complete remote ischemic postcondioning<br>Drug: standard therapy<br>* received standardized treatment<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of glial lymphatic system | The size of the vascular spaces was assessed by brain magnetic resonance of ischemic postcondioning group and standard therapy group | from baseline to 3 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differential expression pattern of differential proteins | Differential expression pattern of differential proteins in blood of patients with remote ischemic postcondioning group and standard therapy group | from baseline to 3 day |