Ketone Supplementation and Exercise Performance

Study Overview
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Brief Summary
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The purpose of this study is to observe the effects of exogenous ketone supplements during shorter bouts of exercise testing on twenty collegiate endurance trained athletes (18-25 years of age).

Detailed Description
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Some believe very high fat diets (>70% energy) can enhance exercise performance by providing additional fuel (ketones) for energy metabolism, at least for very prolonged exercise (>3-4h). Regardless, this diet is difficult to maintain so it has been suggested that ingesting ketone salts along with a normal carbohydrate (CHO) diet might be more practical. The purpose of this study is to observe the effects of ketone salt ingestion on shorter term (up to  15 min) exercise performance. Endurance trained (≥2 year training experience; ≥7 h/week) collegiate athletes (n=20) of similar body mass (♀; 55-60kg; ♂; 75-80kg) and age 18-25y) consuming 5-6g CHO•kg-1•d-1) will be tested before and after 1 and 7d of ketone salt (Prüvit, Carrollton TX, US) supplementation (0.6-0.8g•kg-1•d-1). Participants will perform two exercise performance tests (a 10km cycle time trial and a 30s Wingate cycle test on separate days) before and after supplementation. Blood samples (glucose, lactic acid, and ketone concentration) will be taken at: baseline and following each performance test. It is hypothesized that ketone salt supplementation will increase blood ketone concentration but will not enhance these exercise performance tests.

Official Title
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Can Ketone Supplementation Enhance Exercise Performance?

Conditions
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Ketosis, Exercise Performance, Ketoses, Metabolic

Intervention / Treatment
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* Behavioral: 10 km time trial
* Behavioral: 30s Wingate
* Dietary Supplement: Ketone
* Behavioral: Baseline 10 km time trial
* Behavioral: Baseline 30s Wingate


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy male or female Collegiate Endurance Trained Athletes ≥2 year training experience; ≥7 h/week Ages 18-25 Exclusion Criteria: Smoker Injury that will affect exercise performance Sedentary Behaviour Currently following a High Fat diet/Ketogenic diet Taking Beta Blockers or Hypertension Medication Has Respiratory, Cardiovascular and/or Neuromuscular disease that is not cleared for exercise by a physician.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 25 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Baseline Testing<br>Baseline testing for a 10km cycle time trial and a 30s Wingate cycle test. | Behavioral: Baseline 10 km time trial<br>* A baseline 10 km Cycling time trial test will be conducted<br>Behavioral: Baseline 30s Wingate<br>* A baseline 30s all-out test to measure peak power output<br>|
| Experimental: Dietary Supplement: Exogenous Ketone Salt<br>Ketone salt supplementation (0.6-0.8g•kg-1•d-1) 7-days. Participants will perform two exercise performance tests (a 10km cycle time trial and a 30s Wingate cycle test on separate days) after supplementation. | Behavioral: 10 km time trial<br>* 10 km Cycling time trial test will be conducted to examine the effects of the Exogenous Ketone Salts on time<br>Behavioral: 30s Wingate<br>* 30s all-out test to measure peak power output<br>Dietary Supplement: Ketone<br>* Supplement containing exogenous ketone salts<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 10 km Time trial | 10km time trial where participants will be measured on time to completion | 15-20 Minutes | 
| 30s Wingate | 30s Wingate all out test where participants will be measured on their peak power output | 30 seconds | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood Ketones | Blood Ketones will be measured using a ketone meter | 1-2 hours | 
| Blood Glucose | Blood Glucose will be measured using a Blood glucose meter | 1-2 hours | 
| Blood Lactate | Blood Lactate will be measured using a lactate meter | 1-2 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ketones, Supplementation, Exercise Performance