linjc16/ctgov huggingface dataset:
Study Aimed at Detecting Potential Abuse of Nitrous Oxide in Children During Dental Care

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to evaluate the potential risk of abusive behavior for children in care using nitrous oxide for dental care.

Detailed Description
-----------------
The expected prospects are therefore maintaining surveillance around the MEOPA following his release from hospital reserves, but also to ensure that the MEOPA not an addictive potential in the context of its use in dentistry. The results of this study will in any case to secure its application for dental care.

Official Title
-----------------
Uncontrolled Prospective Single-center Study Aimed at Detecting Potential Abuse of Nitrous Oxide in Children During Dental Care

Conditions
-----------------
Periodontal Disease

Intervention / Treatment
-----------------
* Other: questionnaire


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children aged 3 to 15 years Requiring dental care under MEOPA Not opposing, as well as his parents, his participation in the study Not having difficulties tracking (going on holiday, imminent change, remoteness, lack of motivation) Exclusion Criteria: Excluded patients are those whose dental care can be made to the vigil state, or on the contrary, will present a number of important care, justifying general anesthesia. Also excluded will be children whose parents no longer have parental authority or whose parents are divorced or divorcing.

Ages Eligible for Study
-----------------
Minimum Age: 3 Years
Maximum Age: 15 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: questionnaire|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| presence of clear signs that the child is trying to extend the contact MEOPA ( questionnaire ) | hand gesture to keep the mask over the nose and / or mouth, verbalization of the desire to keep the mask over the nose and / or mouth, to extend the negotiation contac | Baseline | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
dental care, emeno, abuse
Body Composition, Bone Mineral Density, Insulin Sensitivity and Echocardiographic Measurements in Klinefelter Syndrome

Study Overview
=================
Brief Summary
-----------------
Klinefelter syndrome (KS) is the most common sex-chromosome disorder with a prevalence of one in 660 men and is a frequent cause of hypogonadism and infertility. It is caused by the presence of extra X-chromosomes, the most common karyotype being 47,XXY. The phenotype is variable, but the most constant finding is small hyalinized testes, hypergonadotrophic hypogonadism, infertility, eunuchoid body proportion, increased height and learning disabilities. Klinefelter syndrome has been associated with increased prevalence of diabetes, osteoporosis and cardiovascular diseases but the pathogenesis is unknown. Accordingly the aim of the study was to investigate measures of body composition, insulin sensitivity, bone mineral density, echocardiography, as well as biochemical markers of endocrine, metabolic and bone function in KS and an age-matched control group.

Conditions
-----------------
Klinefelter Syndrome, Diabetes, Osteoporosis, Metabolic Syndrome, Cardiovascular Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age above 18 years verified KS karyotype (KS patients) Exclusion Criteria: untreated hypothyroidism or hyperthyroidism present or past malignant diseases clinical liver disease treatment with drugs knowing to interfere with glucose homeostasis, fat metabolism or bone modulation (e.g. glucocorticoids)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| KS<br>Patients with Klinefelter syndrome verified by chromosome analysis | |
| Normal<br>Normal men Age matched to KS patients | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Plasma Level of Mitochondrial DNA in Patients With ARDS and Its Clinical Significance

Study Overview
=================
Brief Summary
-----------------
To observe the changes of plasma mitochondrial DNA (mtDNA) levels in patients with ARDS, and to explore its clinical significance.

Detailed Description
-----------------
60 patients who diagnosed as ARDS were included in this study.Then keep blood samples from these patients in the first day、the third day and the sveventh day,detect the mitochotndrial DNA level in plasma by real-time quantitative PCR. Recored Severity of illness and survival status of every patient within 28 days.Objective to evaluate the correlation between the level of mitochondrial DNA in plasma and the prognosis of the patients.

Official Title
-----------------
Plasma Level of Mitochondrial DNA in Patients With ARDS and Its Clinical Significance

Conditions
-----------------
Evaluate the Correlation Between the Level of Mitochondrial DNA in Plasma and the Prognosis of the Patients With ARDS.

Intervention / Treatment
-----------------
* Other: taking peripheral blood


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients admitted to ICU diagnosed of ARDS (Berlin criteria), Patients age between 18 years old and 80 years. Exclusion Criteria: Pregnant women, Patients with malignant tumor, Immunosuppression or immunocompromised patients.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: taking peripheral blood|taking peripheral blood of no more than 3ml|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mortality |  | 28-day |
Chromosomal Analysis of Single Cells in Human Embryos

Study Overview
=================
Brief Summary
-----------------
Optimise genetic screening of human embryos using higher resolution techniques

Official Title
-----------------
Chromosomal Analysis of Single Cells in Human Embryos

Conditions
-----------------
Chromosomal Abnormalities

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 3-4 day old embryos from IVF couples with both partners younger than 36 years old

Ages Eligible for Study
-----------------
Minimum Age: 3 Days
Maximum Age: 4 Days

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| genetic constitution of single blastomeres |  | 3 day old embryos | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
chromosomal abnormalities in single cells
Evaluation of a New CZT System

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to check if the new CZT system has an advantage in detection of small osseous processes, thyroid adenomas, parathyroid adenomas and detection of sentinel node, in comparison with the techniques in use. Participants: 100 subjects male and female that come to the institute of nuclear medicine for routine screening examinations. The CZT screening takes 10 minutes and does not require any extra intervention to the routine screening.

Official Title
-----------------
Evaluation of a New CZT System for Imaging in Routine Nuclear Medicine Examination

Conditions
-----------------
Parathyroid Adenoma, Thyroid Adenoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age over 18 Exclusion Criteria: pregnancy patients unable to understand and sign an informed consent age under 18

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| hand<br>patients admitted for Tc MDP for evaluation of carpal/metacarpal and finger bone lesions | |
| thyroid<br>patients admitted for Tc thyroid scan | |
| parathyroid<br>patients investigated for parathyroid adenoma | |
| sentinel node<br>patients who are due to sentinel node biopsy | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
CZT, sentinel node, osseous processes
Effect of Wearing of White Coat on Patient Satisfaction in Indian Out Patient Department (OPD) Setting

Study Overview
=================
Brief Summary
-----------------
Doctor's attire acts as an important criteria in setting up good relationship between patient and physician. Recent evidence as well as strong viewpoints have highlighted the possible harm of wearing a white coat. In order to get the patient's perspective on the same, this observational study is being conducted to determine the effect of wearing a white coat on patient satisfaction in an Indian setting , in patients who visit rheumatology outpatient department,in Columbia Asia Hospitals,Bangalore,India.

Official Title
-----------------
Observational Study to Determine the Effect of Wearing of White Coat on Patient Satisfaction in Indian Out Patient Department (OPD) Setting

Conditions
-----------------
Patient Compliance, Physician-Patient Relations

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients aged equal to or greater than 18 years, attending the rheumatology OPD in Columbia Asia Hospitals,Bangalore. Exclusion Criteria: Patient who have come only for diagnostic or therapeutic procedure or for second opinion. Patients without plan for follow up.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in patient satisfaction scores (if any) between patients visiting a rheumatologist for the first time based on the whether the physician dons an apron or not. |  | 50 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in rate of compliance with medications between patients visiting a rheumatologist for the first time based on the whether the physician dons an apron or not. |  | 3 weeks to 1 month. | 
| Change in rate of compliance with follow up visits (if any) between patients visiting a rheumatologist for the first time based on the whether the physician dons an apron or not. |  | 3 weeks to 1 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
White coat physician attire
Does an Additional Antirotation U-Blade (RC) Lagscrew Improve Treatment of AO/OTA (Orthopaedic Trauma Association) 31 A1-3 Fractures With Gamma 3 Nail?

Study Overview
=================
Brief Summary
-----------------
The purpose was to evaluate whether the additional use of the Gamma3 ® RC Lag Screw is associated with a reduced cutout rate in patients with OTA/AO 31A1-3 inter-trochanteric fractures.

Official Title
-----------------
Does an Additional Antirotation U-Blade (RC) Lagscrew Improve Treatment of AO/OTA (Orthopaedic Trauma Association) 31 A1-3 Classified Fractures With Gamma 3 Nail?

Conditions
-----------------
Hip Fractures

Intervention / Treatment
-----------------
* Procedure: Fractures were treated with a Gamma 3 intramedullary nail
* Procedure: Fractures were treated with a Gamma 3 intramedullary nail + U-Blade


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: OTA/AO 31A1-3 fractures treated with Gamma 3® Nail (Stryker Trauma Germany) and either with standard lagscrews or with the Gamma3 ® RC Lag Screw (Stryker Trauma Germany) Exclusion Criteria: Patients with pathological fractures Patients treated with a long gamma nail were excluded

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Gamma 3 Nail<br>Fractures that were treated with a Gamma 3 nail | Procedure: Fractures were treated with a Gamma 3 intramedullary nail<br> <br> |
| Gamma 3 Nail + U-Blade<br>Fractures that were treated with a Gamma 3 nail and additional with antirotation U-blade lag screws. | Procedure: Fractures were treated with a Gamma 3 intramedullary nail + U-Blade<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cutout rate | Differences in the Cutout rate of the femoral head screw with/without U-Blade antirational screw | 3 months after intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mobility | Mobility of the patients 3 months after intervention measured with the Parker mobility score | 3 months after intervention |
RegistRare: a Retro-prospective Registry of Rare Primary Headaches in Italian Tertiary Headache Centres

Study Overview
=================
Brief Summary
-----------------
Retro-prospective survey on specific and overall prevalence and incidence of rare primary headaches (Part One, Chapter 3 and Chapter 4, ICHD-3 beta) in patients referred to Italian Tertiary Headache Centres in a 3-year (May 1, 2014-April 30, 2017 - retrospective data) and annually (from May 1, 2017 - prospective data).

Detailed Description
-----------------
We planned to collect data from May 1, 2014 and afterwards, by means of both retrospective and prospective approaches. All patients who have received or will receive a diagnosis of rare primary headache will be asked to participate and, to this aim, to give their informed consent. Each participating Centre should have received the approval of the competent Ethics Committee before commencing any study procedures. The registry will contain anagraphic information and data about diagnosis, treatment, comorbidity, and clinical features of the headache. Patients' data will be coded through the Italian Health System unique identifier, in order to avoid duplications of patients referring to more than one Centre and also to monitor multiple referrals. A web-based open source platform (SurveyMonkey.org) will be used to collect data.

Official Title
-----------------
RegistRare: a Retro-prospective Registry of Rare Primary Headaches in Italian Tertiary

Conditions
-----------------
Headache Disorders

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: diagnosis of rare primary headaches (Part One, Chapter 3 and Chapter 4, ICHD-3 beta) signed informed consent Exclusion Criteria: none
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence and prevalence in Tertiary headache Centres |  | 10 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
rare headaches, epidemiology
Effect of Floorball on Healthy Subjects

Study Overview
=================
Brief Summary
-----------------
To investigate the effect of floorball on health and performance in healthy subjects over 65 years.

Official Title
-----------------
The Effect of Floorball on Health and Performance Parameters in Healthy Seniors

Conditions
-----------------
Aging Problems

Intervention / Treatment
-----------------
* Behavioral: Floorball


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy age 65-85 physical activity <2 hours pr. week. Exclusion Criteria: age <18 years Injuries that prevent the subject from playing floorball Alcohol >14 units pr. week. Pregnancy Other serious conditions

Ages Eligible for Study
-----------------
Minimum Age: 65 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Floorball<br> | Behavioral: Floorball<br>* The subjects in this group are set to play floorball three times pr. week for 39 weeks.<br>|
| No Intervention: Control<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Echocardiogram | The measure of the hearts geometric dimensions | Changes from baseline measured after 12 weeks and 39 weeks | 
| Bodycomposition | DXA scan | Changes from baseline measured after 12 weeks and 39 weeks |
Comparison Epidural Anesthesia and General Anesthesia in Laparoscopic Cholecystectomy

Study Overview
=================
Brief Summary
-----------------
Comparison of epidural anesthesia and general anesthesia for laparoscopic cholecystectomy, patients in the surgery and the effectiveness of anesthesia after surgery, the incidence of side effects or complications, and postoperative recovery of the body of the differences

Official Title
-----------------
Comparison Epidural Anesthesia and General Anesthesia in Laparoscopic Cholecystectomy

Conditions
-----------------
Epidural Anesthesia, Laparoscopic Cholecystectomy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Underwent laparoscopic cholecystectomy in patients Exclusion Criteria: Unconsciousness or can not express their own feelings of the patient

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Fast Track Admittance of Hip Fracture Patients

Study Overview
=================
Brief Summary
-----------------
The study examines time spent in the emergency room on admission of patients with hip fracture in a cohort with a traditional setup compared with a prospective cohort with a fast track admission schedule including nurse initiation of treatmnet, standardized analgesia, fluid and oxygen therapy and standardized logistics for x-ray and admission procedures.

Official Title
-----------------
Fast Track ER Admittance of Hip Fracture Patients

Conditions
-----------------
Hip Fracture

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Admission with a primary hip fracture Exclusion Criteria: None
Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Bioequivalency Study of Terbinafine Tablets Under Fed Conditions

Study Overview
=================
Brief Summary
-----------------
The objective of this study was the bioequivalence of a Roxane Laboratories' terbinafine tablets, 250 mg, to Lamisil® Tablets, 250 mg (Novartis Pharmaceutical Corporation.) under fed conditions using a single-dose, randomized, 2-treatment, 2-period, 2-sequence crossover design.

Official Title
-----------------
A Single Dose, Two-Period, Two-Treatment, 2-Way Crossover Bioequivalency Study of 250 mg Terbinafine Hydrochloride Tablets Under Fed Conditions

Conditions
-----------------
Onychomycosis

Intervention / Treatment
-----------------
* Drug: Terbinafine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: No clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening. Exclusion Criteria: Positive test for HIV, Hepatitis B, or Hepatitis C. Treatment with known enzyme altering drugs. History of allergic or adverse response to terbinafine or any comparable or similar product.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Terbinafine|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bioequivalence |  | Baseline, Two period, Twenty-one day washout |