Dexmedetomidine Improves Recovery After Cranial Aneurysm Surgery

Study Overview
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Brief Summary
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Dexmedetomidine induces analgesic and sedative effects and is reported to decrease agitation during emergence after general anesthesia in various surgeries. For patients undergoing cranial aneurysm surgeries, a calm anesthesia and emergence is important. In this study, the investigatorstend to observe the effect of dexmedetomidine on maintenance and recovery of patients undergoing cranial aneurysm surgeries.

Official Title
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Effect of Dexmedetomidine on Maintenance and Recovery of Cranial Aneurysm Surgery

Conditions
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Aneurysm Cerebral

Intervention / Treatment
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* Drug: Intravenous dexmedetomidine
* Drug: nasal dexmedetomidine
* Drug: intravenous saline
* Drug: nasal saline


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients undergoing cerebral aneurysm embolism under general anesthesia Exclusion Criteria: patients with bradycardia or atrioventricular heart block patients with ASA(American Society of Anesthesiologists) status over 3 patients with body mass index(BMI)≥30kg/m2 patients with difficulty in communication patients with ruptured aneurysm patients suspected or proved to be pregnant

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: nasal dexmedetomidine<br>dexmedetomidine is given nasally, saline is given intravenously | Drug: nasal dexmedetomidine<br>* drug is nasally given to patients<br>Drug: intravenous saline<br>* saline is given to patients intravenously<br>|
| Experimental: intravenous dexmedetomidine<br>saline is given nasally, dexmedetomidine is given intravenously | Drug: Intravenous dexmedetomidine<br>* drug is intravenously infused to patients<br>Drug: nasal saline<br>* normal saline is given to patients nasally<br>|
| Placebo Comparator: normal saline<br>saline is given nasally and intravenously | Drug: intravenous saline<br>* saline is given to patients intravenously<br>Drug: nasal saline<br>* normal saline is given to patients nasally<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| incidence of coughing |  | from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ricker's agitation-sedation score |  | from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes | 
| score of coughing | 0=no coughing;1=intermittent coughing;2=continuous coughing | from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes | 
| time to response to verbal command |  | from end of infusing anesthetics to response to verbal command,averagely 20 minutes | 
| time to extubation |  | from end of infusing anesthetics to extubation,averagely 28 minutes | 
| blood pressure before and after extubation |  | from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes | 
| blood glucose before and after aneurysm embolism |  | immediately before inserting coil and after finishing inserting coil,an average of 1 hour | 
| blood lactate before and after aneurysm embolism |  | immediately before inserting coil and after finishing inserting coil,,an average of 1 hour | 
| Mini-mental state examination score |  | 24 hours after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dexmedetomidine, general anesthesia, cerebral aneurysm