Evaluation of the Remineralizing Effect of Aloe Vera Versus Diode Laser for Management of Deep Carious Lesions.

Study Overview
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Brief Summary
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The present study will be performed to evaluate: The remineralizing effect of Aloe Vera versus Diode laser on deep carious dentin after selective caries removal.

Detailed Description
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This study was conducted on 45 teeth selected from patients according to inclusion and exclusion criteria. They were selected from the dental clinic in faculty of oral and dental medicine for girls, Al-Azhar University. The procedure was explained and written informed consent was obtained from each patient. The possible discomforts, risks, and benefits were fully explained to the patients. Ethical committee approval was obtained. Protocol of caries removal was Applied Subsequently, the central cariogenic biomasses and superficial part of the necrotic and demineralized dentin was excavated, leaving the leathery dentin layer. Sample grouping: The patients were randomly assigned into three main groups according to the material used (15 for each) which were assessed at different time intervals (B1) after three months,(B2) after six months. A1: cavities will be sealed directly by temporary restorative material (conventional glass ionomer) without any treatment. A2: cavities will be treated by Diode laser then sealed directly by temporary conventional glass ionomer. A3: cavities will be treated with Aloe Vera then sealed directly by temporary conventional glass ionomer. Evaluation of the remineralization effect of Each group will be assessed radiographically immediately at base line (B0), after three months (B1) and six months (B2) to evaluate the dentin remineralization.

Official Title
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Evaluation of the Remineralizing Effect of Aloe Vera Versus Diode Laser for Management of Deep Carious Lesions

Conditions
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Deep Caries

Intervention / Treatment
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* Other: no intervention
* Device: diode laser
* Dietary Supplement: Aloe Vera


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subject must have active deep carious lesion. clinical and radiographic examinations of carious lesions. Exclusion Criteria: Teeth with pulpal involvement Teeth with abscess Teeth with pain or swelling Teeth with developmental disorders Teeth with adjacent soft tissue lesions patients with systemic illness will be excluded

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: no intervention<br>No Intervention: conventional selective caries removal without treatment After taking the first sample of dentin, the cavity will be restored | Other: no intervention<br>* treatment of deep carious lesions<br>|
| Experimental: diode laser treatment<br>After selective caries removal the cavity was irradiated in contact mode with continuous wave of radiation through a 400µm flexible fiber that was inserted inside the cavity with a spiral continuous movement clockwise from the top to the floor and anti-clockwise in the reverse direction. Irradiation time was 15 seconds and repeated three times for 15 seconds interval with contact, pulsed mode and the output power was adjusted at 1.30 Watt. | Device: diode laser<br>* laser light for cavity disinfection<br>|
| Experimental: Aloe Vera treatment<br>After selective caries removal the lesions were treated with aloe Vera paste which was prepared by mixing aloe Vera powder by distilled water until a thick paste is formed. the paste was applied to the prepared floor by condenser to cover the remaining carious lesion | Dietary Supplement: Aloe Vera<br>* herbal dietary supplement for treatment of deep carious lesions<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| assessment of the remineralizing effect of aloe vera and diode laser on deep caries | remineralisation will be assessed by radiodensity using digital radiography | 6 months |