Olfactory Function and Olfactory Bulb Volume in Acromegaly Patients

Study Overview
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Brief Summary
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A prospective, controlled, single blinded study was planned. 20 patients with Acromegaly (Acromegaly Group) and 20 healthy subjects (Control Group) were planned to include in the study. Connecticut Chemosensory Clinical Research Center (CCCRC) test was applied to evaluate olfactory functions. Olfactory bulb(OB) volumes were measured with a 1.5 T General Electric Signa Excite MRI scanner.

Detailed Description
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Acromegaly patients were assessed at the Endocrinology Department for their clinical symptoms, and the nasal examination and olfactory evaluation were done at the Department of Otorhinolaryngology. OB volume was evaluated by a single blinded radiologist. Control group patients that had similar demographical characteristics with the Acromegaly Group were recruited in the study. The CCCRC test is composed of n-butanol odor threshold test and odor identification test. Olfactory tests were scored out of 7 (0: worst, 7: best olfaction) and mean score was calculated as the total CCCRC test score. OB measurements were done individually on the right and left olfactory bulbs and the mean OB volume was calculated in cubic millimeters.

Official Title
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Olfactory Function and Olfactory Bulb Volume in Acromegaly Patients

Conditions
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Acromegaly, Olfactory Disorder

Intervention / Treatment
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* Other: OB volume
* Other: CCCRC test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Acromegaly diagnosis Healthy subjects that had no nasal problems Exclusion Criteria: Previous nasal surgery Acute respiratory tract infection Nasal polyposis Nasal pathologies that causes nasal obstruction

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Acromegaly group<br>CCCRC test and OB volume results | Other: OB volume<br>* The mean OB volume was calculated in cubic millimeters and compared between the two groups.<br>Other: CCCRC test<br>* CCCRC test was done for olfactory function assessment and compared between the two groups.<br>|
| Other: Control Group<br>CCCRC test and OB volume results | Other: OB volume<br>* The mean OB volume was calculated in cubic millimeters and compared between the two groups.<br>Other: CCCRC test<br>* CCCRC test was done for olfactory function assessment and compared between the two groups.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Olfactory bulb (OB) volume | Measurements were done individually on the right and left OB, and the mean OB volume was calculated in cubic millimeters. The mean OB volume was compared between the two groups. | 18 months | 
| CCCRC test results | Olfactory tests were scored out of 7 (0: worst, 7: best olfaction) and mean score was calculated as the total CCCRC test score. The mean score was compared between the two groups. | 18 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Acromegaly, Olfaction, Olfactory disorder