Nutriomics and Artificial Intelligence Nutrition Obesity Cohort

Study Overview
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Brief Summary
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The purpose of this study is to establish a prospective cohort. From registration to the 5th year, basic investigation, specific examinations for cardiovascular and metabolic disease, basic blood tests, collection of human material samples, and clinical event follow-up are conducted yearly. The obese group will be examined yearly, and telephone follow-up will be conducted if necessary. The control group will participate in the baseline survey once enrollment and clinical event follow-up by phone will be conducted annually thereafter. From the 6th year, only clinical event follow-up will be conducted.

Detailed Description
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The obese group will enroll 500 people within 1 year of study initiation and follow-up annually. The control group will enroll 30 patients a year for 5 years.

Official Title
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Nutriomics and Artificial Intelligence Nutrition Obesity Cohort

Conditions
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Obesity

Participation Criteria
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Eligibility Criteria
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Inclusion criteria for the obese group Adults 19 years of age or older Obese patients with chronic diseases such as cardiovascular disease, hypertension, diabetes, and metabolic syndrome (BMI ≥ 25 kg/m2, [BMI ≥ 30 kg/m2, including 10% or more]) Inclusion criteria for the control group Adults 19 years of age or older Those with BMI 18.5 24.9 kg/m2 Exclusion criteria for the obese group Serious non-cardiovascular disease with life expectancy less than 6 months Pregnant or suspected of being pregnant or are lactating Patients within 3 months of organ transplantation Patients currently being treated for acute transplant rejection Patients treated for acute coronary syndrome (myocardial infarction, unstable angina) and discharged within 6 months Patients with acute cerebral infarction within 6 months of being hospitalized and discharged Type 1 Diabetes Patients taking steroids, female hormones Those who have difficulty using smartphones Exclusion criteria for the control group Serious non-cardiovascular disease with life expectancy less than 6 months Pregnant or suspected of being pregnant or are lactating Persons who are continuously taking medications prescribed by a doctor due to chronic diseases excluding hypertension and dyslipidemia Within 5 years of diagnosis of malignant tumor Those who have difficulty using smartphones

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| The obese group<br>Obese patients (BMI ≥25 kg/m2) with chronic diseases such as cardiovascular disease, hypertension, diabetes, and metabolic syndrome. More than 10% of the patients in the obese group will be patients with a BMI ≥30. | |
| The control group<br>Adults with BMI 18.5 24.9 kg/m2. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differences of nutriomics according to obesity phenotypes | Cross-sectional analysis of nutriomics of normal control group and obese patients | At five years of study | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical events | A composite of all-cause mortality, cardiovascular mortality, non-fatal myocardial infarction, non-fatal stroke, revascularization of coronary artery, and heart failure hospitalization | three years, four years, five years, etc |