Porous and Non-porous Bone Grafts in Intra-bony Periodontal Defects

Study Overview
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Brief Summary
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Till date, no study has been reported in the literature where porous bioactive glass was used for the management of periodontal osseous defects. In this context, the present study is designed to assess the efficacy of the porous variant of bioactive glass and compare with that of nonporous variant using cone beam computed tomography.

Detailed Description
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OBJECTIVES: To evaluate clinically the periodontal healing with Porous variant of Bioactive Glass placed in the intra bony defects at an interval of 6 months. To evaluate clinically the periodontal healing with Non Porous variant of Bioactive Glass placed in the intra bony defects at an interval of 6 months. To evaluate the radiographic changes in the intra bony defect grafted with Porous variant of Bioactive Glass at baseline and an interval of 6 months. To evaluate the radiographic changes in the intra bony defect grafted with Non Porous variant of Bioactive Glass at baseline and an interval of 6 months. To compare clinically soft tissue healing for sites grafted with Porous variant of Bioactive Glass and sites grafted with Non Porous variant of Bioactive Glass in the treatment of periodontal intra bony defects at an interval of 6 months. To compare the radiographic changes for sites grafted with Porous variant and sites grafted with Non Porous of Bioactive Glass in the treatment of periodontal intra bony defects at an interval of 6 months.

Official Title
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Comparative Evaluation of Porous and Non Porous Variants of Bioactive Glass in the Treatment of Periodontal Intrabony Defects: A Cone Beam Computed Tomography Analysis

Conditions
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Periodontal Disease

Intervention / Treatment
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* Drug: Porous variant of Bioactive Glass.
* Drug: Non porous variant of Bioactive Glass.


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: INCLUSION CRITERIA Age: 18-55 years. Probing Depth >5mm. Exclusion Criteria: EXCLUSION CRITERIA History of periodontal treatment last six months. Bleeding disorders. Gross oral pathology.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: porous bone graft group<br>Intervention: Flap surgery procedure with porous bone grafting (Periooglass) | Drug: Porous variant of Bioactive Glass.<br>* Flap surgery with Porous variant of Bioactive Glass.<br>|
| Active Comparator: Non-porous bone gaft group<br>Intervention: Flap surgery procedure with non-porous bone grafting (Novabone morsels) | Drug: Non porous variant of Bioactive Glass.<br>* Flap surgery with non-Porous variant of Bioactive Glass.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in relative attachment loss |  | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in probing depth |  | 6 months | 
| Change in plaque index |  | 6 months |