Current Use in Intensive Care Units by Intensivists of Antihypertensive Drugs

Study Overview
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Brief Summary
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Multicenter, prospective and observational study of practices and impacts of the use of antihypertensive therapies in intensive medicine and intensive care

Detailed Description
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Multicenter, prospective observational cohort study on 200 patients, by doctor's questionnaire on the prescription of antihypertensive drugs in intensive care, follow-up over 72 hours of the prescription.

Official Title
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Current Use in Intensive Care Units by Intensivists of Antihypertensive Drugs

Conditions
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Antihypertensive Drugs in ICU

Intervention / Treatment
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* Other: Inventory of prescribing habits and detect any differences in efficacy and tolerance of antihypertensive drugs


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patient Admitted to an intensive care unit Patient having presented a state of circulatory shock, defined by the need for continuous administration of a vasopressive amine for at least one hour, among: Noradrenaline, Adrenaline In whom the introduction of drug treatment for antihypertensive purposes is decided Exclusion Criteria: Patient admitted to intensive care for a hypertensive emergency (hypertensive surge or malignant arterial hypertension leading to organ dysfunction Patient who has already received at least one anti-hypertensive drug during his stay in intensive care Cerebro-injured patient, proven or suspected cerebral edema, head trauma <1 month, decrease in cerebral perfusion measured Proven or suspected active bleeding Patient refusal of participation

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Inventory of prescribing habits and detect any differences in efficacy and tolerance of antihypertensive drugs|Time to monitor blood pressure values in target targets Need for administration of another antihypertensive drug Disappearance of organ failure attributable to hypertension Weaning from an extra-renal purification Weaning from mechanical ventilation Improved kidney function Iatrogenic hypotension Need for suspension of treatment Other side effect|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Make an inventory of prescribing habits and detect any differences in efficacy and tolerance of antihypertensive drugs in intensive care and intensive care settings | Description in number of drugs | 60 days after inclusion | 
| Make an inventory of prescribing habits and detect any differences in efficacy and tolerance of antihypertensive drugs in intensive care and intensive care settings | Description in percentage of drugs | 60 days after inclusion | 
| Make an inventory of prescribing habits and detect any differences in efficacy and tolerance of antihypertensive drugs in intensive care and intensive care settings | therapeutic classes | 60 days after inclusion | 
| Make an inventory of prescribing habits and detect any differences in efficacy and tolerance of antihypertensive drugs in intensive care and intensive care settings | administration methods | 60 days after inclusion | 
| Make an inventory of prescribing habits and detect any differences in efficacy and tolerance of antihypertensive drugs in intensive care and intensive care settings | prescription chronology | 60 days after inclusion | 
| Make an inventory of prescribing habits and detect any differences in efficacy and tolerance of antihypertensive drugs in intensive care and intensive care settings | reasons for prescribers | 60 days after inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Search for efficiency differences between the different molecules | Time to control blood pressure values in the targeted targets | 60 days after inclusion | 
| Search for efficiency differences between the different molecules | Need for administration of another antihypertensive drug | 60 days after inclusion | 
| Search for efficiency differences between the different molecules | Disappearance of organ failure attributable to hypertension | 60 days after inclusion | 
| Search for efficiency differences between the different molecules | Weaning from an extra-renal purification | 60 days after inclusion | 
| Search for efficiency differences between the different molecules | Weaning from mechanical ventilation | 60 days after inclusion | 
| Search for efficiency differences between the different molecules | Improved kidney function | 60 days after inclusion | 
| Search for differences in side effects between the different molecules | Iatrogenic hypotension | 60 days after inclusion | 
| Search for differences in side effects between the different molecules | Need for suspension of treatment | 60 days after inclusion | 
| Search for differences in side effects between the different molecules | Other side effect | 60 days after inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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intensive care, antihypertensive drugs