Concentrated Growth Factor Versus Platelet Rich Fibrin in Revitalization of Necrotic Young Permanent Incisors

Study Overview
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Brief Summary
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Regenerative endodontic procedures (REPs) are the most recent proposal to manage immature permanent teeth with necrotic pulps. So in this study, the investigator will evaluate the clinical and radiographical revitalization success in necrotic young permanent anterior teeth of participants by using Concentrated Growth Factor versus Platelet-Rich Fibrin

Detailed Description
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Official Title
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Concentrated Growth Factor Versus Platelet Rich Fibrin in Revitalization of Necrotic Young Permanent Incisors

Conditions
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Necrotic Pulp

Intervention / Treatment
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* Procedure: revitalization by concentrated growth factor


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy patients with immature permanent incisors Presence of clinical signs and symptoms of necrosis or chronic apical periodontitis. The chronic apical periodontitis signs and symptoms include little discomfort with intermittent episodes of pus discharge through the sinus tract. Exclusion Criteria 1. Abnormal tooth mobility. Positive history of allergic reaction, systemic diseases, severe emotional or behavioral problems. Unrestorable teeth Abnormal tooth mobility Children with systemic, severe behavioral, or emotional problems

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 11 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: parallel assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: revitalization by concentrated growth factor<br>modified platelet concentrate | Procedure: revitalization by concentrated growth factor<br>* modified platelet concentrate<br>* Other names: revitalization by platelet rich fibrin;|
| Active Comparator: revitalization by platelet rich fibrin<br>platelet concentrate | Procedure: revitalization by concentrated growth factor<br>* modified platelet concentrate<br>* Other names: revitalization by platelet rich fibrin;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical success rate | Regaining tooth vitality with electric pulp testing Clinical examination includes pain absence, normal tooth mobility, and no sensitivity to percussion | one year | 
| Radiographic success using Periapical index (PAI) | Criteria of PAI scores: score 1 normal periapical structure score 2 small changes in bone structures score 3 changes in bone structure with some mineral loss score 4 periodontitis with well-defined radiolucent area score 5 severe periodontitis with exacerbating features | one year |