Acute Pain Memory Among Former Burned: Exploration of fMRI.

Study Overview
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Brief Summary
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Pain is complex phenomenon misunderstood in spite of medical progress and neurosciences. That's why the relief of chronic pain is only partial for a lot of infection as arthrosis, chronic back pain, headaches or neuropathic pain. Certain situations bring to relive pain sensation. Investigators were interested to former burned. They wonder about somatic memory and unconscious of acute.

Detailed Description
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It is a comparative and monocentric study. There are two groups. On the one hand, there is the former burned and, on the other hand, healthy volunteers. While they thought to painful memory or not, functional Magnetic Resonance Imaging (fMRI) will be performed. Then, investigators compare two functional Magnetic Resonance Imaging (fMRI). Main objective of this study is link up between brain activity by functional Magnetic Resonance Imaging (fMRI) and acute pain memory.

Official Title
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Acute Pain Memory Among Former Burned: Exploration of Functional Magnetic Resonance Imaging (fMRI).

Conditions
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Magnetic Resonance Imaging, Neuronal Activity

Intervention / Treatment
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* Other: fMRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: For control group: Affiliated or entitled to a social security Have signed consent before their participation in the study Adult women and men french and is right handed Vision and hearing normal or corrected For former burned: Affiliated or entitled to a social security Have signed consent before their participation in the study Adult women and men french and is right handed Vision and hearing normal or corrected Localized burn at the hand or feet onset between 12 and 24 years Not sequelae painful at the inclusion Scope and depth of the burn according to classifications CIM 10 Exclusion Criteria: For control group: Any contraindications to pass an fMRI test Neuropathic pains and psychiatric disorders Medical history of head injuries Burn presence For former burned: Any contraindications to pass an fMRI test Neuropathic pains and psychiatric disorders Medical history of head injuries

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Two groups: 20 patients and 20 healthy volunteers
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: patients<br>Patient who was burned will have fMRI. | Other: fMRI<br>* During fMRI, patients and control group will have to thought to seven painful memories, seven emotional memories not painful, seven neutral memories. At every memory there is control test. It is to count backwards.<br>* Other names: functional Magnetic Resonance Imaging (fMRI);|
| Active Comparator: control group<br>Healthy volunteers (control group) will have fMRI. | Other: fMRI<br>* During fMRI, patients and control group will have to thought to seven painful memories, seven emotional memories not painful, seven neutral memories. At every memory there is control test. It is to count backwards.<br>* Other names: functional Magnetic Resonance Imaging (fMRI);|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| BOLD (blood-oxygen-level dependent) signal between painful memories | Correlation between BOLD measured by functional Magnetic Resonance Imaging (fMRI) and every conditions: painful memories, emotional memories not painful, neutral memories and control test. | Months 3 | 
| BOLD (blood-oxygen-level dependent) signal between emotional memories not painful | Correlation between BOLD measured by functional Magnetic Resonance Imaging (fMRI) and every conditions: painful memories, emotional memories not painful, neutral memories and control test. | Months 3 | 
| BOLD (blood-oxygen-level dependent) signal between neutral memories | Correlation between BOLD measured by functional Magnetic Resonance Imaging (fMRI) and every conditions: painful memories, emotional memories not painful, neutral memories and control test. | Months 3 | 
| BOLD (blood-oxygen-level dependent) signal between control test. | Correlation between BOLD measured by functional Magnetic Resonance Imaging (fMRI) and every conditions: painful memories, emotional memories not painful, neutral memories and control test. | Months 3 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| BOLD (blood-oxygen-level dependent) signal between control group for every conditions | Correlation between BOLD measured by functional Magnetic Resonance Imaging (fMRI) and groups for every conditions: painful memories, emotional memories not painful, neutral memories and control test. | Months 3 | 
| BOLD (blood-oxygen-level dependent) signal between patients for every conditions | Correlation between BOLD measured by functional Magnetic Resonance Imaging (fMRI) and groups for every conditions: painful memories, emotional memories not painful, neutral memories and control test. | Months 3 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pain, Brain responses, Neuroimaging, fMRI, Burn, Memory