NT-proBNP and Troponin I in Dengue Children

Study Overview
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Brief Summary
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To discribe concentration of NT-proBNP and Troponin I in Dengue hemorrhagic shock children, in correlation between concentration of NT-proBNP and troponin I with total fluid admission, respiratory support, using inotrope and vasopressor using.

Detailed Description
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Treatment of children with Dengue hemorrhagic shock syndrome (DSS) is challenge, especially in cases with hypotensive shock, profound shock or whom do not have a response to initial crystalloid therapy. Currently, treatment of DSS remains almost supportive, with particular emphasis on careful fluid management. However, fluid overload is a common complication of this treatment, lead to many difficulties in management of severe Dengue children, accompany with morbidity and mortality. Diagnosis of fluid overload mostly based on clinical features and chest X-ray or ultrasound. Until now, no biomarker are widely using for diagnosis of fluid overload in clinical. NT-proBNP is secreted when stretching the wall of the cardiac muscle. This may a suitable biomarker to discover the fluid overload state in children with DSS. Troponin I is a biomarker of cardiac muscle damage.

Official Title
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NT-proBNP and Troponin I in Children With Dengue Hemorrhagic Shock: a Longitudinal Study

Conditions
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Dengue Shock Syndrome, Children, Only

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Dengue shock children who admitted to ICU Exclusion Criteria: Excluding the cases of children with cardiovascular disease, hyperthyroidism, taking drugs such as insulin, steroid, estrogen, growth hormone, thyroid hormone

Ages Eligible for Study
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Minimum Age: 1 Month
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Concentration of NT-proBNP | Concentration of NT-proBNP in Children with Dengue hemorrhagic shock and severe shock | 10 days | 
| Concentration of Troponin I | Concentration of Troponin I in Children with Dengue hemorrhagic shock and severe shock | 10 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cut-off value of NT-proBNP for fluid overload | Cut-off value of NT-proBNP for pulmonary edema | 14 days | 
| Correlation between concentration of NT-proBNP | Correlation between concentration of NT-proBNP with total fluid admission, respiratory support, using inotrope and vasopressor using | 14 days | 
| Correlation between concentration of Troponin I | Correlation between concentration of Troponin I total fluid admission, respiratory support, using inotrope and vasopressor using | 14 days | 
| Rate of clinical manifestations | Rate of clinical manifestations: fever, abdominal pain, petechia, hematomegaly | 14 days | 
| Rate of abnormal laboratory exam | electrolyte, arterial blood gas, lactate | 14 days | 
| Rate of abnormal liver, kidney, hematology laboratory exam | AST, ALT, ure, creatinin, PLT, PT, aPTT, Fibrinogen | 14 days | 
| Rate of NS1 Dengue | Positive | 10 days | 
| Rate of MAC ELISA IgM Dengue | Positive | 14 days | 
| Rate of complications | Pulmonary edema | 14 days | 
| Rate of respiratory support | Cannula, NCPAP, Intubation | 14 days | 
| Rate of intubation | Positive | 14 days | 
| Rate of mode of ventilation | PC, IP, PEEP, FiO2, VT | 14 days | 
| Total fluid administration | ml/kg/d | 14 days | 
| Time for IV fluid administration | hours | 14 days | 
| Rate and kind of cephalosporin using | 3rd generation cephalosporin | 14 days | 
| Rate and kind of Carbapenem using | Carbapenem | 14 days | 
| Rate and kind of Vancomycin using | Vancomycin | 14 days | 
| Rate of intraperitoneal fluid drainage | Positive | 14 days | 
| Rate of CRRT | Positive | 14 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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NT-proBNP, Troponin I, Dengue children, Cardiac enzyme