Comparison of Deep Neuromuscular Block and Moderate Neuromuscular Block on Quality of Recovery in Patients Undergoing Robotic Gastrectomy

Study Overview
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Brief Summary
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The purpose of this study is to investigate and compare the postoperative quality of recovery between the deep neuromuscular blockade and moderate neuromuscular blockade during robotic gastrectomy.

Conditions
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General Anesthesia

Intervention / Treatment
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* Drug: Deep neuromuscular blockade
* Drug: Moderate neuromuscular blockade


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adult patients aged 19-80 years who are scheduled for robotic gastrectomy Exclusion Criteria: Neuromuscular disease History of malignant hyperthermia Significant renal or hepatic dysfunction Allergy to sugammadex or rocuronium

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Deep neuromuscular blockade<br>Rocuronium will be administered continuously to achieve post-tetanic count 1-2 during surgery. | Drug: Deep neuromuscular blockade<br>* neuromuscular blockade will be performed using a continuous infusion of rocuronium. Post-tetanic count 1-2 will be maintained during surgery. After the end of surgery, sugammadex of 4 mg/kg will be administered to reverse neuromuscular blockade.<br>|
| Active Comparator: Moderate neuromuscular blockade<br>Rocuronium will be administered continuously to achieve Train-of-four 1-2 during surgery. | Drug: Moderate neuromuscular blockade<br>* neuromuscular blockade will be performed using a continuous infusion of rocuronium. Train-of-four 1-2 will be maintained during surgery. After the end of surgery, sugammadex of 2 mg/kg will be administered to reverse neuromuscular blockade.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative quality of recovery | The postoperative quality of recovery will be evaluated at 24 and 48 hours after the end of surgery by the investigator who are blinded to the group assignments. | within 48 hours after the end of surgery. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Surgical condition | Surgical condition will be evaluated after the end of surgery by the investigator who are blinded to the group assignments. | within 48 hours after the end of surgery | 
| shoulder pain | shoulder pain will be evaluated after the end of surgery by the investigator who are blinded to the group assignments. | within 48 hours after the end of surgery | 
| abdominal pain | abdominal pain will be evaluated after the end of surgery by the investigator who are blinded to the group assignments. | within 48 hours after the end of surgery | 
| nausea and vomiting | nausea and vomiting will be evaluated after the end of surgery by the investigator who are blinded to the group assignments. | within 48 hours after the end of surgery |