Cortical Activation in Individuals With Finger Amputation During Mirror Versus Imagery Treatment

Study Overview
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Brief Summary
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Goals : ( a) to examine differences in cortical activity during hand movements with a mirror compared to imagery of the same movements, and (b) to examine correlation between cortical activity during imagery or mirror treatment and the pain and performance measures in finger amputees. A cross-sectional study of 20 subjects in a Functional Magnetic Resonance Imaging (fMRI) preforming mirror therapy hand movement and imagery hand movement. Also, Visual Analogue Scale for pain and the Disability of the Arm, Shoulder and Hand (DASH) questionnaire and Jebsen Taylor Hand Function Test will be used.

Detailed Description
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Goals : ( a) to examine differences in cortical activity during hand movements with a mirror compared to imagery of the same movements, and (b) to examine correlation between cortical activity during imagery or mirror treatment and the pain and performance measures in finger amputees. A cross-sectional one-meeting study of 20 subjects (finger amputees) in a Functional Magnetic Resonance Imaging (fMRI) preforming mirror therapy hand movement and imagery hand movement. Also, Visual Analogue Scale for pain and the Disability of the Arm, Shoulder and Hand (DASH) questionnaire and Jebsen Taylor Hand Function Test will be used.

Official Title
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Cortical Activation in Individuals With Finger Amputation During Mirror Versus Imagery Treatment

Conditions
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Amputees

Intervention / Treatment
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* Other: Mirror
* Other: Imagery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Following unilateral traumatic finger or fingers amputation (1 to 3 fingers) Self-reported limited functionality, sensory disorder or pain Exclusion Criteria: Are not comparable with MRI restrictions Chronic pain disease Psychiatric condition

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 67 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Amputees<br>The subjects will receive both mirror and imagery treatments in a cross-over design. | Other: Mirror<br>* The healthy hand will be mirrored and the amputated hand unseen by the subject while performing hand movements.<br>Other: Imagery<br>* The subject will be asked to imagine performing hand movements.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cortical activity | Activation of supplementary motor area (SMA), S1 and M1. | 1 hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual analogue scale | Filled by the subject for subjective pain in residuum discomfort. | 10 minutes | 
| Disability of the Arm, Shoulder and Hand | Questionnaire regarding the disability and daily activities difficulties. | 30 minutes | 
| The Jebsen Taylor Hand Function Test | Standard evaluation of hands functionality. | 30 minutes |