Pyruvic Acid Versus Salicylic Acid Preparation in Treatment of Plantar Warts

Study Overview
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Brief Summary
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Plantar warts can be bothersome and painful requiring treatment. The investigators will compare the efficacy of pyruvic acid and salicylic acid in treating multiple plantar warts. Patients with multiple plantar warts will be randomized to receive either pyruvic acid 70% or compound salicylic acid solution (salicylic acid 16.7%, lactic acid 16.7%, and collodion 100%) applying topically twice a day for 4 weeks. Patients will be visited every 2 weeks for one month after starting treatment and then every one month for up to 3 months. The number and size of warts will be evaluated.

Official Title
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Comparison of 70% Pyruvic Acid Solution and Duofilm Solution in Treatment of Plantar Wart

Conditions
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Plantar Wart

Intervention / Treatment
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* Drug: Pyruvic acid
* Drug: Salicylic Acid


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: aged 12 years and above multiple warts (at least 2) Exclusion Criteria: mosaic warts already under any treatment for warts pregnant or lactating women

Ages Eligible for Study
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Minimum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Pyruvic acid<br>Patients will receive pyruvic acid solution 70% prepared by solving of pyruvic acid in water/ethanol solution. Patients will be advised to apply the solution twice daily for a period of four weeks. Application of petrolatum to the surrounding normal skin protects against the corrosive effect of the concentrated acid. | Drug: Pyruvic acid<br> <br> |
| Active Comparator: Salicylic acid<br>Patients will receive a combination of salicylic acid 16.7%, lactic acid 16.7%, and collodion 100%. Patients will be advised to apply the solution twice daily for a period of four weeks. Application of petrolatum to the surrounding normal skin protects against the corrosive effect of the concentrated acid. | Drug: Salicylic Acid<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Wart number | Patients will be visited every two weeks for one month and then every month for up to 3 months by a dermatologist. On each visit, warts will be inspected to determine the number of warts. Any wart totally non-detectable by inspection and touch will be considered as healed. | From before to 3 months after | 
| Wart size | Patients will be visited every two weeks for one month and then every month for up to 3 months by a dermatologist. On each visit, warts will be inspected to determine the size of warts. The size of the warts will be calculated as the mean size of all the warts. | From before to 3 months after | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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wart, verruca vulgaris, topical therapy, pyruvic acid, salicylic acid