Radiofrequency Ablation in Thyroid Nodules

Study Overview
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Brief Summary
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Thyroid nodules are common problems and although > 95% are stated to be benign, they may cause some problems like hyperthyroidism, compression symptoms, and cosmesis associated with their function, size and localization. Especially for these nodules, patients undergo surgery and face up with the problems associated with surgical complications although they are not cancer. In some studies, radiofrequency ablation previously used for intrabdominal tumors like hepatic metastasis...,was stated to be efficient in the treatment of benign thyroid nodules and in some recurrent thyroid cancer cases. Therefore, the investigators decided to use this method in our patients having nodules like previously mentioned and see the efficacy and safety of the technique.

Official Title
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Efficacy of Radiofrequency Ablation in Thyroid Nodules

Conditions
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Thyroid Nodules

Intervention / Treatment
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* Procedure: Radiofrequency ablation of the thyroid nodule


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: the presence of subjective symptoms (foreign body sensation, neck discomfort or pain, compressive symptom) or cosmetic problems; a poor surgical candidate or refusal to undergo surgery; fine-needle aspiration cytology and US findings that were compatible with a benign nodule; anxiety about a malignancy. Exclusion Criteria: a nodule less than 5 mm in size; follicular neoplasm or malignancy on fine needle aspiration cytology (FNAC); a nodule with the sonographic criteria for a malignancy (taller than wide, marked hypoechoic, microcalcifications, ill-defined margins), although FNAC was a benign result; previous radiation or operation history to the head and neck; (5) previous sclerosing therapy.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: radiofrequency ablation of thyroid nodule<br>Under ultrasonography the thyroid nodules will be ablated by radiofrequency ablation | Procedure: Radiofrequency ablation of the thyroid nodule<br>* Under USG control, the nodule will be ablated by radiofrequency with a needle that has an active tip of 1 cm.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Shrinkage of the thyroid nodule after radiofrequency ablation |  | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disappearance of the nodules in follow up |  | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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radiofrequency, thyroid, nodule