Have a Good Grasp of the Worldthe World

Study Overview
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Brief Summary
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Brief Summary: In schizophrenia, dislocation of psychic functions involving a loss of contact with reality is frequently found. A fragmentation of motor and sensory perceptions could be held responsible. However, automatic integration between perception and action is the necessary condition to be in relationship with the world. Affordance is the experimental link between object perception and potentially associated actions (Gibson, 1977, 1979) explored by Stimulus Response Compatibility (SRC) paradigm. With Tucker & Ellis sensory motor compatibility task (1998), with a modified response device (responses given with grasp), we study the impact of motor activation on these affordance effects. In this study, a group of controls will also be included in order to understand, as precisely as possible, the mechanisms involved (i.e., interference between the perception of the object and the response gesture).

Detailed Description
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Schizophrenic patients will perform: Alert TEA, (Zimmermann and Fimm, 2005), Edinburgh laterality questionnaire (Oldfield, 1971), IQ test (IQ: PM38, Raven, 1960), and the PANSS (Positive and Negative Syndrome Scale, Kay et al., 1987). Controls will only perform the laterality questionnaire. Then all will perform the affordance task, in which photographs of 20 objects of everyday life, typically graspable with one hand, are presented in 4 orientations. Participants have to respond in a graspable device, as quickly as possible, if the object is presented upright or inverted.

Official Title
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Study on the Links Between Action and Perception in Schizophrenia,  Have a Good Grasp of the World 

Conditions
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Schizophrenic Disorders

Intervention / Treatment
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* Other: cognitive tasks + PANSS+ IQ
* Other: cognitive tasks


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: For patients: a DSM-IV diagnosis of schizophrenia (men or women), no change in antipsychotic medication and clinical status within four weeks prior to the study For patients and control group • Age ≥ 18 years et ≤ 55 years Exclusion Criteria: History of head trauma, neurological disease with cerebral repercussion or not stabilized serious physical illness; psychotropic medication disorders related to the use of a psychoactive substance (abuse, dependence or withdrawal); Exclusion Criteria: For patients: • IQ < 70 For patients and control group History of head trauma, neurological disease with cerebral repercussion or not stabilized serious physical illness; psychotropic medication disorders related to the use of a psychoactive substance (abuse, dependence or withdrawal);

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patients<br>patients suffering schizophrenic disorders and who will perform cognitive tasks + PANSS+ IQ | Other: cognitive tasks + PANSS+ IQ<br>* Patients will perform different tasks: reaction time (Alert TEA, Zimmermann and Fimm, 2005), Edinburgh laterality questionnaire (Oldfield,1971), IQ test (IQ: PM38, Raven, 1960), and the PANSS (Positive and Negative Syndrome Scale (Kay et al., 1987) + the experimental task (affordance task with graspable device)<br>|
| Active Comparator: Control group<br>healthy patients who will perform cognitive tasks | Other: cognitive tasks<br>* Healthy volunteers will perform only Edinburgh laterality questionnaire (Oldfield, 1971) + the experimental task (affordance task with graspable device).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| response time | The gain provided by the compatible vs incompatible conditions (ms response time) | day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Schizophrenia, affordance,, perception-action binding,, stimulus-response-compatibility