Physiological Factors That Influence Maintenance of Lifestyle Changes and Weight Loss - a Cross-sectional Study

Study Overview
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Brief Summary
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In Denmark and the western world, there is an increasing prevalence of obesity probably due to a combination of inadequate daily physical activity and a high energy intake. One approach to achieve weight loss and change life style is to participate in an intensive supervised prolonged life style modification course. The immediate effect is often positive, but over time the overall effect is limited as the majority will not maintain weight loss and a changed life style. The purpose of this study is therefore to characterize the physiological factors that determine/influence the capacity to maintain weight loss and a healthy lifestyle after a prolonged lifestyle intervention. The investigators have the following research questions: Are there physiological traits and characteristics that mediate better adherence to lifestyle changes and weight loss? Does the adaptation in muscle oxidative capacity after lifestyle intervention predict success in maintaining weight loss and lifestyle changes? How does gender and age influence the capacity to maintain the lifestyle induced adaptation in muscle and adipose tissue and maintaining weight loss? The study design is cross-sectional and will be based on a lifestyle intervention, as it is practiced in a real life setting at Ubberup folk high school. The investigators will recruit former participants of this lifestyle style intervention. 50 % who maintained a weight loss and a healthy life style and 50 % who did not.

Official Title
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Physiological Factors That Influence Maintenance of Lifestyle Changes and Weight Loss - a Cross-sectional Study

Conditions
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Obesity, Overweight

Intervention / Treatment
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* Behavioral: Intensive Lifestyle Intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Former participants of Ubberup Folk High School Exclusion Criteria: Gastric Bypass Surgery or Gastric Banding

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Intensive Lifestyle Intervention<br>Former participants of Ubberup Folk High Schools intensive lifestyle intervention programme. | Behavioral: Intensive Lifestyle Intervention<br>* The included subjects has previously participated in the Intensive Lifestyle Intervention intervention at Ubberup Folk High School. This intervention includes daily exercise and a hypocaloric diet (app. -700KCal/day) for 10-14 weeks. Furthermore theoretical and practical education within e.g. Nutrition, exercise and motivational psychology.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total Body weight |  | 0-14 years after the intervention is completed | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anthropometry | Body composition measured by dual x-ray absorptiometry or bio-impedance, height, weight, waist circumference. | 0-14 years after the intervention is completed | 
| Maximal fat oxidation | Respiratoric Exchange Ratio (RER) is measured during an incremental cycling test and maximal fat oxidation is calculated | 0-14 years after the intervention is completed | 
| Maximal Oxygen Consumption |  | 0-14 years after the intervention is completed | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Weight loss maintenance, Body composition, Physical activity, Lifestyle intervention