Postoperative Quality of Recovery After Transurethral Resection of the Bladder

Study Overview
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Brief Summary
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Transurethral resection of the bladder (TURB) is often performed as an outpatient procedure so high-quality postoperative recovery is particularly important. The aim of this study is to compare postoperative quality of recovery after spinal anesthesia (SA) and general anesthesia (GA) for transurethral resection of the bladder.

Detailed Description
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After written informed consent is obtained seventy patients aged 18-80 years, ASA (American Society of Anesthesiologists) physical status class I-III scheduled for TURB will be randomly assigned to either spinal anesthesia or general anesthesia. Spinal anesthesia will be performed with 12.5 mg of bupivacaine mixed with 25 mcg of fentanyl. General anesthesia will be performed with propofol and fentanyl and maintained with sevoflurane, without use of neuromuscular blocking agents. Quality of Recovery 40 questionnaire (QoR-40) administered before and 24 hours after surgery will be used for assessment of postoperative recovery.

Official Title
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Postoperative Quality of Recovery After Transurethral Resection of the Bladder: Spinal Versus General Anesthesia

Conditions
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Urinary Bladder Neoplasms, Transurethral Resection of the Bladder, Postoperative Recovery

Intervention / Treatment
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* Procedure: Spinal anesthesia
* Procedure: General anesthesia
* Drug: bupivacaine
* Drug: fentanyl
* Drug: propofol
* Drug: sevoflurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Transurethral resection of the bladder Age 18 to 80 years ASA I-III Exclusion Criteria: Contraindications for spinal anesthesia Chronic pain with use of opioids in the last week Psychiatric disorders Allergy to medications used in the study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Spinal anesthesia<br>Transurethral resection of the bladder performed under spinal anesthesia. | Procedure: Spinal anesthesia<br> <br> Drug: bupivacaine<br> <br> Drug: fentanyl<br> <br> |
| Active Comparator: General anesthesia<br>Transurethral resection of the bladder performed under general anesthesia. | Procedure: General anesthesia<br> <br> Drug: fentanyl<br> <br> Drug: propofol<br> <br> Drug: sevoflurane<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of Recovery 40 (QoR-40) | Quality of Recovery 40 questionnaire at 24 hours | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative opioid consumption | Postoperative opioid consumption over 24 hours | 24 hours | 
| Postoperative pain measured with visual analogue scale | Postoperative pain measured with visual analogue scale at 1,6 and 24 hours | 1,6 and 24 hours | 
| Patient satisfaction with anesthesia measured with numerical rating scale | Overall patient satisfaction with anesthesia measured with numerical rating scale | 24 hours |