Bayesian Estimation of Diagnostic Performance of Diabetic Cardiovascular Autonomic Neuropathy Without a Gold Standard

Study Overview
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Brief Summary
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This study aimed to estimate sensitivities and specificities of diabetic cardiovascular autonomic neuropathy (DCAN) diagnostic tests using the Bayesian approach without a gold standard in another independence dataset.The reference the values for the short-term HRV were calculated in the investigators' previous study (including 371 healthy subjects). This study dataset contained 200 diabetic patients who completed both the short-term HRV test and Ewing's test. Simultaneous inferences about the population prevalence and the performance of each diagnostic test were possible using the Bayesian approach without a gold standard.

Detailed Description
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The CAN prevalence is rapidly growing in all populations worldwide. No document has been reported diagnostic performance of short-term heart rate variability (HRV) for diabetic cardiovascular autonomic neuropathy (DCAN) in the Chinese population. This study aimed to estimate sensitivities and specificities of DCAN diagnostic tests using the Bayesian approach, in the absence of a gold standard in another independence dataset.The reference the values for the short-term HRV were calculated in the investigators' previous study (including 371 healthy subjects). This study dataset contained 200 subjects who completed both the short-term HRV test and Ewing's test. Simultaneous inferences about the population prevalence and the performance of each diagnostic test were possible using the Bayesian approach without a gold standard.

Official Title
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Bayesian Estimation of Diagnostic Performance of Short-term Heart Rate Variability for Diabetic Cardiovascular Autonomic Neuropathy in the Absence of a Gold Standard

Conditions
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Diabetic Cardiovascular Autonomic Neuropathy (DCAN)

Intervention / Treatment
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* Other: not intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Survey diabetic participants with undiagnosed CAN, aged 30-90 years, were included in this study. Exclusion Criteria: Some subjects were excluded from the study to eliminate potential confounding factors that may have influenced their CA function. Briefly, the exclusion criteria were as follows: history or findings of arrhythmia, and hyperthyroidism or hypothyroidism; pregnancy or lactation; and/or serious hepatic or renal dysfunctions.

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Dr.Tang's research group<br>This group included diabetic participants with completed both the short-term HRV test and Ewing's test. | Other: not intervention<br>* This is a cross-sectional study for estimation of diagnostic performance.<br>* Other names: nothing;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diabetic cardiovascular autonomic function evaluate by short-term heart rate variability test | Both short-term heart rate variability and Ewing's test measure diabetic cardiovascular autonomic function | participants will be measured for the duration of outpatient stay, an expected average of two days | 
| Diabetic cardiovascular autonomic function evaluate by Ewing's test | Both short-term heart rate variability and Ewing's test measure cardiovascular autonomic function | participants will be measured for the duration of outpatient stay, an expected average of two days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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DCAN, Bayesian estimation, short-term heart rate variability, diabetic cardiovascular autonomic neuropathy, diagnostic performance, Diagnostic performance, short-term heart rate variability, diabetic cardiovascular autonomic neuropathy