Living Conditions After Non-Hodgkin's Lymphoma in France

Study Overview
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Brief Summary
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This is an innovative project, allowing to study for the first time the long-term living conditions of patients after diffuse large B-cell lymphoma (DLBCL) or follicular lymphoma (FL) from population data in France. Patients will be selected from the three specialized hematology registries in France: Côte-d'Or, Gironde and Basse-Normandie. This is also one of the first studies to look at epidemiological indicators of net survival after diagnosis of follicular lymphoma and diffuse large B-cell lymphoma, adjusted for clinical factors such as disease stage, therapeutic management, and comorbidities, apart from the standard adjustment factors of age, sex, and time of diagnosis in real life. In addition, the proportion of cured patients will be estimated. For component 1, this will be the survival analysis on the initial data. For part 2, questionnaires will be sent out followed by a follow-up if necessary one month after the mailing. There is no physical interview nor any specific biological or imaging examination.

Official Title
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Living Conditions After Non-Hodgkin's Lymphoma in France

Conditions
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Non-hodgkin's Lymphoma

Intervention / Treatment
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* Other: Data collection
* Other: Questionnaires


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis period 2010-2018, according to the 2008 WHO ICD-O-3 classification, from the hematological malignancy registries of Côte-d'Or, Gironde, Basse-Normandie Patients with a diagnosis of follicular lymphoma (9690/3, 9691/3, 9695/3, 9698/3, 9597/3) Patients with a diagnosis of diffuse large B-cell lymphoma (9678/3, 9679/3, 9680/3, 9684/3, 9688/3, 9712/3, 9735/3, 9737/3, 9738/3) For Part 2: Individuals alive at the date of vital status update Non-inclusion criteria: Other forms of malignant hemopathies at diagnosis, Minors. Exclusion Criteria: Person under a legal protection measure (curatorship, guardianship) Person under a legal protection measure (guardianship, tutorship) Pregnant, parturient or breastfeeding women Major incapable or unable to express his consent Person who did not return the questionnaires following the 1-month follow-up, or patient who expressed refusal to participate.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Part 1: Patients diagnosed with non-Hodgkin's lymphoma<br>Diagnosis period 2010-2018, from the hematological malignancy registries of Côte-d'Or, Gironde, Basse-Normandie | Other: Data collection<br>* Data from hematological malignancy registries<br>|
| Part 2: Patients diagnosed with live non-Hodgkin's lymphoma after vital status update<br>Update of vital status in December 2022 | Other: Questionnaires<br>* 9 questionnaires were sent out: QLQ-C30 and SF-12 Quality of Life Questionnaire. Oral quality of life questionnaire QLQ-OH15 Sexuality questionnaire SHQ-C22 Anxiety and depression questionnaire HADS, Rosenberg Self-Esteem Questionnaire RNLI Reintegration to Normal Life Questionnaire Social Support Questionnaire SSQ6, Socio-economic status questionnaire EPICES, Complementary questionnaire collecting data on socio-professional status.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression-free survival | Update of vital status (part 1) | December 2022 | 
| Generic SF-12 questionnaire | Mesure of the quality of life (part 2) | October 2024 | 
| Specific QLQ-C30 questionnaire | Mesure of the quality of life (part 2) | October 2024 |