linjc16/ctgov huggingface dataset:
Cholestanol in Humans

Study Overview
=================
Brief Summary
-----------------
The treatment of cerebrotendinous xanthomatosis an in born error of bile acid synthesis with chenodeoxycholic acid. Patients with this disease over produce cholestanol and bile acid precursors because of the block in synthesis. Replacement with chenodeoxycholic acid shut down abnormal pathway and reduces elevated level of cholestanol and improves the clinical syndrome.

Detailed Description
-----------------
Cerebrotendinous xanthomatosis is a recessively inherited in born of bile acid synthesis due to a mutation in sterol 27-hydroxylase (CYP27A1). Patients with this disease suffer from xanthomas located in the brain and tendon, accelerated atherosclerosis progression neurologic disease and cataracts. Plasma cholesterol levels are normal but cholestanol and C-27 bile alcohol that precursor of bile acid synthesis accumulate and are believe are responsible for the atherosclerosis, xanthomas and neurologic disease. Analysis of the bile reveal a severe sufficiency of the primary bile acid chenodeoxycholic acid that can not be produce because of the inherited defect. However, replacement of chenodeoxycholic acid in the enterohepatic pool inhibit abnormal bile acid synthesis and reduces the elevated level of cholestanol and C-27 bile alcohol this therapy halt the neurologic disease and prevents symptomatic atherosclerosis developing.

Official Title
-----------------
Biologic Significance of Cholestanol in Man

Conditions
-----------------
Cerebrotendinous Xanthomatosis

Intervention / Treatment
-----------------
* Drug: Chenodeoxycholic Acid


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with clinical and biochemical findings of cerebrotendinous xanthomatosis. Elevated levels of serum cholestanol and bile acid precursors. Exclusion Criteria:

Ages Eligible for Study
-----------------
Minimum Age: 5 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Non-Randomized
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Arm 1<br> | Drug: Chenodeoxycholic Acid<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
bile acid synthesis, chenodeoxycholic acid, sterol 27-hydroxylase
Environmental Surveillance (ES) for Polio and AMR Using the TaqMan Array Card

Study Overview
=================
Brief Summary
-----------------
This study will be used to develop a tool to streamline poliovirus environmental surveillance for the polio endgame and to provide a tool for detecting polio in places where there is no capacity to carry out the gold standard culture-based detection.

Detailed Description
-----------------
This environmental surveillance tool will also include antimicrobial resistance (AMR) genes to describe resistome profile in environmental samples and to better inform us of the potential risks of exposure to these environments

Official Title
-----------------
Evaluation of TaqMan Array Card for Environmental Surveillance of Polio Virus and Antimicrobial Resistance Genes

Conditions
-----------------
Polio

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria birth-4 years of age reside in selected urban slums of Mirpur Dhaka, Bangladesh receiving bOPV immunization Exclusion Criteria: parent unwilling to consent

Ages Eligible for Study
-----------------
Maximum Age: 4 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Polymerase Chain Reaction (PCR) detection of poliovirus, enteric pathogens and antimicrobial resistance genes from environmental samples | Evaluate performance of the TaqMan Array Card (TAC) on environmental samples (sewage samples) collected in urban slum area of Mirpur. The primary purpose will be to use TAC to detect and monitor Sabin 1 and 3 polio viruses post SIA. | through study completion, an average of 1 year |
Progestin Treatment for Endometrial Stromal Cells in Adenomyosis

Study Overview
=================
Brief Summary
-----------------
Long term treatment of progestin has been demonstrated to have an inhibitory effect on endometrial angiogenesis and the proliferation of endometrial stromal cells. As a result, progestin is now widely employed in the treatment of endometrial cancer, endometrial hyperplasia, and dysfunction uterine bleeding. In the treatment of adenomyosis, however, the beneficial effect of progestin was limited. It might imply that the behavior of endometrial cells in women with adenomyosis is different from that in women without adenomyosis. Our previous study revealed that the expression of killer inhibitory receptors (KIRs) on NK cells was decreased in eutopic endometrium in women with adenomyosis. It may be a compensatory effect in which the NK cytotoxicity is activated in order to wipe out the abnormal endometrial cells that might go out of the eutopic site of endometrium. It implies that the formation of adenomyosis might be due to abnormal endometrial tissues, but not the aberrant local immunological dysfunction in myometrium. This finding is compatible with previous reports in which eutopic endometrium obtained from women with endometriosis or adenomyosis was found to behave differently from endometrium in unaffected women. In this study, we try to collect endometrial tissues from women with and without adenomyosis, and then purify the endometrial stromal cells from endometrium. The endometrial stromal cells are cultured for 8 days with the supplement of medroxyprogesterone (MPA) or danazol. Quantification of IL-6 and IL-8 mRNA in endometrial cells, and the concentrations of IL-6 and IL-8 in cultured media will be done with real time RT-PCR and ELISA respectively. The expression of different cytokines of endometrial cells in response to progestin might be further elucidated after our experiment.

Detailed Description
-----------------
Eutopic endometrium was obtained and separated into single endometrial stromal cell (ESC) in women with adenomyosis (study group) and without adenomyosis (control group). After becoming pre-confluent (covering 80% of the culture well), ESC was cultured for 8 days solely or with the addition of medroxyprogesterone (MPA) or danazol. ELISA was done to measure IL-6, IL-8, and TNF-alpha concentrations of the culture media. Real-time quantitative RT-PCR was done to measure IL-6, IL-8, and TNF-alpha RNA levels in ESC.

Conditions
-----------------
Endometriosis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: women with adenomyosis at early- to mid-secretory phases Exclusion Criteria: postmenopausal malignancy

Ages Eligible for Study
-----------------
Minimum Age: 35 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Novel Treatment For Pusher Syndrome Using Physical Therapy

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to see if a specific physical therapy intervention speeds recovery from stroke-related pusher syndrome.

Conditions
-----------------
Pusher Syndrome

Intervention / Treatment
-----------------
* Other: Novel physical therapy
* Other: Standard physical therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Recent (within 2 months) unilateral stroke Burke Lateropulsion Scale ≥ 2 Age 21 to 89 years Ability to provide informed consent English-speaking Exclusion Criteria: Prior stroke within the past 6 months Cerebellar stroke Stroke-related brain imaging (MRI or CT) unavailable Global or receptive aphasia Prior documented neurologic disorder (e.g., multiple sclerosis, Parkinson's)

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 89 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Control<br>Standard Physical Therapy | Other: Standard physical therapy<br> <br> |
| Experimental: Intervention<br>Novel Physical Therapy | Other: Novel physical therapy<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recovery from pusher syndrome as measured by changes in the Burke Lateropulsion Scale score over time. | The Burke Lateropulsion Scale (BLS) is used in the literature to measure the presence of pusher syndrome. We will measure BLS upon admission and at weekly intervals to monitor whether patients in the experimental group demonstrate faster recovery than the control group, as demonstrated by change in BLS score over change in time (days). | Initial, and then weekly until discharge from inpatient rehabilitation unit. Average inpatient stay is expected to be no greater than 4 weeks. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
stroke, pusher syndrome, contraversive pushing, lateropulsion, rehabilitation, physical therapy
Presurgical Language Mapping With fMRI: Comparison of BOLD and fASL Techniques

Study Overview
=================
Brief Summary
-----------------
One of the aim of the neurosurgical treatment of brain tumor is to offer the maximal resection with the minimal neurological risk. The presurgical mapping of eloquent areas with functional magnetic resonance imaging (fMRI) is helpful to plan the surgery. BOLD fMRI is now the gold standard to map language areas. However, BOLD signal is diminished near the brain tumor. It is now possible to detect cortical activation with arterial spin labeling (ASL) techniques, detecting variations of perfusion during an activation paradigm (fASL), fASL could be interesting to detect eloquent areas near a brain tumor.

Official Title
-----------------
Presurgical Language Mapping With fMRI: Comparison of BOLD and fASL Techniques

Conditions
-----------------
Brain Neoplasms

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient 18 years and older Brain tumor involving frontal and/or temporal lobe and/or insula, with scheduled neurosurgery Patient able of accepting protocol information Patient who received information about the protocol and had not expressed its opposition to participate Exclusion Criteria: Patient with any surgical clip, external clips, or any other ferromagnetic device, that is contraindicated for use in MRI Claustrophobic patient Patients who cannot cooperate for the fMRI Patients subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Qualitative and quantitative comparison of brain activations obtained with both techniques (BOLD fMRI and fASL) | Qualitative and quantitative comparison of brain activations obtained with both techniques (BOLD fMRI and fASL) to presurgically detect language areas located near a brain tumor | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Langage laterality index obtained with both techniques (BOLD fMRI and fASL)and fASL) | Size and location of activations obtained with BOLD fMRI and fASL in the presurgical detection of language areas | 2 years | 
| Difference of cerebral blood flow maps obtained with ASL and fASL | Cerebral blood flow quantification obtained with standard ASL and extracted from fASL | 2 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Magnetic Resonance Imaging
Randomized Controlled Trial of Multi-Source Feedback to Pediatric Residents

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to test whether multi-source feedback, including self-assessment and tailored coaching, improves resident communication skills and professionalism. We hypothesize that residents who are assigned to receive multi-source feedback, in addition to receiving standard feedback, will improve significantly more than residents receiving standard feedback alone, as measured by parent and nurse ratings of specific behaviors over time.

Official Title
-----------------
Randomized Controlled Trial of Multi-Source Feedback to Pediatric Residents: The Formative Value of an ACGME Competency-Based Assessment Tool.

Conditions
-----------------
Education, Medical, Education, Competency-Based, Feedback, Communication, Humanism

Intervention / Treatment
-----------------
* Behavioral: Multi-Source Feedback: including self-assessment & coaching


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Residents entering their first year of training Scheduled for the two pediatric inpatient rotations where parent and nurse evaluations would be collected Exclusion Criteria: Residents from combined Internal Medicine/Pediatric training programs

Ages Eligible for Study
-----------------
Minimum Age: 0 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Educational/Counseling/Training
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Multi-Source Feedback: including self-assessment & coaching|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The difference between groups in the change in parent and nurse ratings of specific communication skills and professionalism behaviors from baseline to follow-up (average 5 months later) |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Education, Medical, Education, Competency-Based, Multi-Source Feedback, Communication, Professionalism
Urethral Sensory Profile: a New Technique to Evaluate Urethral Sensation Prospective Evaluation in Patients With or Without Neurological Disorders

Study Overview
=================
Brief Summary
-----------------
This is a routine evaluation of urethral sensation during urodynamic studies. The record has been realized retrospectively. The investigators propose a new way to represent urethral sensation, in a simple and non-invasive way.

Detailed Description
-----------------
All patients consulting for urodynamics were included. During the introduction of the urinary catheter for urodynamic evaluation, patients were asked to report pain and/or desire to void felt at every centimeter (cm)of insertion, on an analogic visual scale graded from 0 to 10. The USP was defined by the graphic representation of the successive values of these sensations , from the urinary meatus, to the urinary bladder.

Official Title
-----------------
Urethral Sensory Profile: a New Technique to Evaluate Urethral Sensation Prospective Evaluation in Patients With or Without Neurological Disorders

Conditions
-----------------
Urethral Cyst

Intervention / Treatment
-----------------
* Other: record of urethral pain sensation during urodynamics study


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients consulting in our department for a urodynamic study Exclusion Criteria: chronic pelvic pain difficulties for understanding or for communicating

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: record of urethral pain sensation during urodynamics study|Record of pain using a VAS scale during the first catheterizing of urodynamics study, at every centimeter|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Urethral Sensitive profile | record of urethral pain sensation during the first catheterizing of urodynamics study | mars 2015 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
urodynamics, urethral sensation, urethral pain
Assessment of Drug Prescription by Phone

Study Overview
=================
Brief Summary
-----------------
Prescription of medicines by telephone in French medical call Centres is a part of the general practitioners activity. This study aimed to described drug prescription by phone (MTP) performed in four medical call centers. The primary objective is to evaluate adherence to french practice guidelines for the drug prescription by phone (Haute Autorité de Santé, 2009) The secondary objective is to evaluate the risk/benefit ratio for drug prescription by phone.

Official Title
-----------------
Telemedicine Performed by General Practitioners in Medical Call Centres:Quality Assessment of Drug Prescription by Phone

Conditions
-----------------
Drug Advice by Phone

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All phone calls, from september to october 2013, leading to a drug prescription by a general practitioner of four medical call centres.. Exclusion Criteria: Medical emergency Patient refusing or not able to provide consent.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adherence to Practice Guidelines for the drug prescription by phone | The aim is to measure the adherence to HAS (Haute Autorité de Santé, 2009) pratice guidelines for the drug prescription by phone | 3 days | 
| Risk/benefit ratio for drug prescription by phone |  | 3 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Drug advice by phone, Teleprescription, Medical call centre, Out of hours call
Withings Pulse Wave Velocity and Blood Pressure Study

Study Overview
=================
Brief Summary
-----------------
Measure pulse wave velocity stability in relation to time of day, day of the week, physical activity, sleep quality, stress levels and blood pressure.

Detailed Description
-----------------
The study population will be an estimated 300 healthy adult subjects from the United States. This population will be approximately 150 men and 150 women. In order to obtain a relatively diverse age range of users (with varying levels of arterial stiffness), we hope to enroll participants across three age ranges entered in the Withings application by the user: 18-40 years, 41-60 years, and > 60 years. These spots will be filled by those that satisfy the inclusion/exclusion criteria on a first come, first served basis.

Official Title
-----------------
Withings Pulse Wave Velocity and Blood Pressure Study

Conditions
-----------------
Elevated Blood Pressure, Hypertension, Mental Stress, Sleep Disorders

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: User of a (1) Withings blood pressure cuff (2) Withings activity tracker and (3) Withings Body Cardio scale User has measured their blood pressure at least once per week for the majority of weeks over the last three months. Exclusion Criteria: Aortic artery disease Peripheral vascular disease Atrial fibrillation Weight > 396 lbs. Pregnant women

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measure pulse wave velocity (PWV) stability in relation to time of day, day of the week, physical activity, sleep quality, stress levels and blood pressure. | The study population will be an estimated 300 healthy adult subjects from the United States who own a Withings blood pressure cuff, Withings activity tracker, and Withings Body Cardio scale and have measured their blood pressure at least once per week for the majority of weeks over the last three months. | Subjects will be expected to participate for a total of 16 weeks. |