Body Composition Study in Critically Ill Patients-Extended to COVID-19

Study Overview
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Brief Summary
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Muscle loss (ultrasound quadricep muscle) and muscle strength (handgrip and knee extension strength) will be compared between COVID-19 and non COVID-19 critically ill patients.

Detailed Description
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Given the heightened inflammatory status among COVID-19 critically ill patients, we hypothesized that the rate of skeletal muscle loss is accelerated in this population, and this loss is even more pronounce than the general critically ill patients. We further hypothesized that the increased muscle loss will lead to worse functional outcome (lower muscle strength) in COVID-19 critically ill patients compared with age- and sex-matched non-COVID-19 critically ill patients, as it has been shown that quadriceps thickness is strongly correlated with functional status at ICU discharge. Furthermore, a recent systematic review and meta-analysis in survivors of coronavirus (severe acute respiratory syndrome, SARS or Middle-east respiratory syndrome, MERS, or COVID-19) also demonstrated reduced exercise capacity and quality of life at 6 months after hospitalization or ICU admission

Official Title
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Body Composition Study in Critically Ill Patients-Extended to COVID-19

Conditions
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Critical Illness, Covid19, Muscle Atrophy, Muscle Strength

Intervention / Treatment
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* Other: No Intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ≥ 18 years old Admitted into the ICU due to COVID-19 Exclusion Criteria: Likely to transfer out from the ICU in 24 hours from screening Likely to die in the next 7 days Bedbound prior to hospital admission or bedbound in the hospital for >10 days

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| ICU COVID-19 patients<br>COVID-19 patients that are admitted into the ICU and fulfilled the eligibility criteria | Other: No Intervention<br>* This is an observational study and involved no intervention<br>|
| ICU non-COVID-19 patients<br>Non-COVID-19 patients that are admitted into the ICU matched with ICU COVID-19 patients that are recruited and fulfilled the eligibility criteria | Other: No Intervention<br>* This is an observational study and involved no intervention<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rectus Femoris Thickness | Change in Rectus Femoris Thickness | Change in Rectus Femoris Thickness at day 7 or ICU discharge or hospital discharge compared with baseline (Day 1 of ICU admission) | 
| Rectus Femoris Cross-sectional Area | Change in Rectus Femoris Cross-sectional Area | Change in Rectus Femoris Cross-sectional Area at day 7 or ICU discharge or hospital discharge compared with baseline (Day 1 of ICU admission) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Forearm Muscle Thickness | Change in Forearm Muscle Thickness | Change in Forearm Muscle Thickness at day 7 or ICU discharge or hospital discharge compared with baseline (Day 1 of ICU admission) | 
| Handgrip Strength | BIlateral Handgrip Strength | Before Hospital Discharge | 
| Knee Extension Strength | BIlateral Knee Extension Strength | Before Hospital Discharge |