Beijing Children and Adolescents Metabolic Syndrome Study (BCAMS Study)

Study Overview
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Brief Summary
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Base on enriched resources from the Metabolic Syndrome cohort in children, a long-term prospective cohort study will be carried out. This cohort is a unique biochemical and genetic database of Chinese population with large number of subjects in the world. By collecting information of disease history and lifestyle, measuring clinical and metabolic parameters, especially biomarkers which can reflect the underlying mechanism of insulin resistance and metabolic syndrome, we intend to sort out some unique biochemical and genetic markers for Chinese population.

Detailed Description
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A representative sample of 19,593 school children, aged 6-18 years, were chosen from four of the eight urban districts and three of seven rural districts in the Beijing area between April and October, 2004. Among these children and adolescents, 4,500 were recognized as having risk factors defined by the presence of any one of the following: overweight, total cholesterol (TC) ≥ 5.2 mmol/L, triglyceride (TG) ≥ 1.7 mmol/L or fasting glucose (FG) ≥ 5.6 mmol/L based on initial finger capillary blood tests. Moreover, all subjects at increased risk for metabolic syndrome, together with a parallel reference population of 1,095 children, were invited to undergo medical examinations for verification based on venipuncture blood samples. Clinical data, biomarkers including adipokines, and lifestyle factors such as physical activity and diet were measured and documented. Genetic variants previously reported from genome-wide association study (GWAS) of obesity and diabetes and DNA-methylation were also assessed. Further, high-throughput analysis of proteomics and metabolomics of the blood samples were conducted. Cross-sectional and follow-up evaluations will be undertaken. The unique biochemical and genetic markers for Chinese population will be identified in the BCAMS study. The biomarkers will build a solid foundation for progressive study on mechanism of metabolic diseases and lead to early prediction of these diseases.

Official Title
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Beijing Children and Adolescents Metabolic Syndrome Study (BCAMS Study)

Conditions
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Obesity, Metabolic Disease

Intervention / Treatment
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* Other: No intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Children aged 6 to 18 years old from Beijing area in China Exclusion Criteria: Children or their parents refused to participate in the study

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: No intervention|No intervention|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Metabolic syndrome | The presence of pediatric metabolic syndrome (MS) at baseline was defined by the modified criteria of Adult Treatment Panel III (ATP III). | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Metabolic syndrome | Metabolic syndrome in adolescents and adults after follow-up was defined by the harmonized definition. | At 10-year follow-up | 
| Obesity | The participants' height and weight were measured under standardized conditions by trained staff. Body mass index (BMI) was calculated as weight (kg) divided by height squared (m^2). Normal weight, overweight and obesity were defined by age- and gender-specific BMI percentiles according to the criteria from the Working Group on Obesity in China. | Baseline | 
| Obesity | The participants' height and weight were measured under standardized conditions by trained staff. Body mass index (BMI) was calculated as weight (kg) divided by height squared (m^2). | At10-year follow-up | 
| Insulin resistance | Insulin resistance index was calculated by homeostasis model assessment of insulin resistance (HOMA-IR), HOMA-IR = fasting insulin (mU/L) × FG (mmol/L) / 22.5. | Baseline | 
| Insulin resistance | Insulin resistance index was calculated by homeostasis model assessment of insulin resistance (HOMA-IR), HOMA-IR = fasting insulin (mU/L) × FG (mmol/L) / 22.5. | At 10-year follow-up | 
| Hypertension | Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured in the right arm three times, 10 minutes apart, and the average of the three measurements was used in the analysis.Hypertension is defined by SBP / DBP ≥ 90th percentile for age, gender for subjects less than 18 years. | Baseline | 
| Hypertension | Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured in the right arm three times, 10 minutes apart, and the average of the three measurements was used in the analysis.Hypertension is defined by SBP ≥ 130 mmHg or DBP ≥ 85 mmHg for adults. | At 10-year follow-up | 
| Hyperglycemia | The concentrations of plasma glucose (mmol/L). | Baseline | 
| Hyperglycemia | The concentrations of plasma glucose (mmol/L). | At 10-year follow-up | 
| Triglyceride (TG) | The concentrations of plasma triglyceride (TG) (mmol/L). | Baseline | 
| Triglyceride (TG) | The concentrations of plasma triglyceride (TG) (mmol/L). | At 10-year follow-up | 
| Total cholesterol (TC) | The concentrations of plasma total cholesterol (TC) (mmol/L). | Baseline | 
| Total cholesterol (TC) | The concentrations of plasma total cholesterol (TC) (mmol/L). | At 10-year follow-up | 
| High-density lipoprotein cholesterol(HDL-C) | The concentrations of plasma high-density lipoprotein cholesterol(HDL-C) (mmol/L). | Baseline | 
| High-density lipoprotein cholesterol(HDL-C) | The concentrations of plasma high-density lipoprotein cholesterol(HDL-C) (mmol/L). | At 10-year follow-up | 
| Low-density lipoprotein cholesterol (LDL-C) | The concentrations of plasma triglyceride low-density lipoprotein cholesterol (LDL-C) (mmol/L). | Baseline | 
| Low-density lipoprotein cholesterol (LDL-C) | The concentrations of plasma triglyceride low-density lipoprotein cholesterol (LDL-C) (mmol/L). | At 10-year follow-up | 
| Left ventricular mass | Assessment by a non-invasive transthoracic echocardiogram using a LOGIQ P5 B-mode ultrasonogram equipped (LOGIQ P5, GE Ultrasound, Korea) with a 2.5-3.5 MHz probe. | At 10-year follow-up | 
| Non Alcoholic Fatty Liver Disease | Nonalcoholic fatty liver disease (NAFLD) was diagnosed by B ultrasonography according to the 2010 Prevention and Treatment Guidelines for NAFLD published by the Society of Hepatology, Chinese Medical Association. | At 10-year follow-up | 
| Self-concept | The Chinese version of the Self-Description Questionnaire II (SDQ-II) was used to assess self-concept. | At 10-year follow-up | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Children, Obesity, Metabolic Disease