Intervention Strategy in Chronic Obstructive Pulmonary Disease With Anxiety and Depression

Study Overview
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Brief Summary
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Anxiety and depression have negative effect on outcomes of chronic obstructive pulmonary disease (COPD). Intervention strategy including behavioral-cognitive therapy and pulmonary rehabilitation are promising in improving life quality, disease symptom and outcomes. But there's not standard algorithm in China so far. The study aims to compare the effectiveness of these interventions and develop an intervention algorithm of anxiety and depression in COPD.

Official Title
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Intervention Strategy in Chronic Obstructive Pulmonary Disease With Anxiety and Depression

Conditions
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COPD, Anxiety, Depression

Intervention / Treatment
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* Behavioral: Cognitive Behavioral Therapy
* Behavioral: Pulmonary Rehabilitation Therapy
* Behavioral: Combined Therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Stable COPD patients with mild or moderate anxiety and depression Exclusion Criteria: Patients with bronchial asthma or other severe pulmonary diseases or having received pulmonary surgery in 6 months Patients with tumor history during past 5 years Patients with COPD exacerbations during past 4 weeks Participants in clinical trials Patients in pregnancy or breastfeeding Patients unable to complete questionaire independently Patients older than 80 years old Patients receiving long-term domiciliary oxygen therapy

Ages Eligible for Study
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Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cognitive Behavioral Therapy<br>receive cognitive-behavioral therapy for 12 weeks | Behavioral: Cognitive Behavioral Therapy<br>* 12 weeks cognitive-behavioral lessons, once a week<br>|
| Experimental: Pulmonary Rehabilitation Therapy<br>receive pulmonary rehabilitation therapy for 12 weeks | Behavioral: Pulmonary Rehabilitation Therapy<br>* 12 weeks pulmonary rehabilitation exercise<br>|
| Experimental: Combined Therapy<br>receive both cognitive-behavioral therapy and pulmonary rehabilitation therapy for 12 weeks | Behavioral: Combined Therapy<br>* cognitive-behavioral lessons and pulmonary rehabilitation exercise for 12 weeks<br>|
| No Intervention: Regular Therapy<br>receive regular therapy for chronic obstructive pulmonary disease | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hospital Anxiety and Depression Scale | total score | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| moderate and severe COPD exacerbations | total times | 3 years | 
| modified British medical research council score | total score | 3 years | 
| COPD assessment test score | total score | 3 years |