Insulin Sensitivity in Patients With Atopic Dermatitis

Study Overview
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Brief Summary
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The incidence of atopic dermatitis and type 2 diabetes, respectively, has increased over many years. Novel research shows an association between the two conditions. While this relationship at least in theory can be explained by lifestyle factors, there is reason to believe that other pathophysiological mechanisms are involved. Hence, our hypothesis is that patients with atopic dermatitis are insulin resistant due to their chronic inflammatory state. Insulin resistance might play an unknown part in the increased frequency of type 2 diabetes among patients with atopic dermatitis. In the present project, the investigators aim to measure insulin sensitivity by means of the 'golden standard' hyperinsulinaemic euglycaemic clamp in patients suffering from atopic dermatitis compared to a healthy control group (matched case-control study). The project is a close collaboration between The Department of Dermatology and Allergy and Center for Diabetes Research at Gentofte Hospital.

Official Title
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Insulin Sensitivity in Patients With Atopic Dermatitis

Conditions
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Atopic Dermatitis/Eczema, Type 2 Diabetes

Intervention / Treatment
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* Diagnostic Test: Hyperinsulinemic euglycemic clamp


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Moderate to severe atopic dermatitis for at least 5 years BMI < 30 kg/m2 HbA1c < 42 mmol/mol Exclusion Criteria: Diabetes Prediabetes First-degree relatives with diabetes Chronic inflammatory diseases other than atopic dermatitis and asthma Pregnancy Breast-feeding Daily intake of medications that are known to influence the glucose metabolism are not allowed one month before the study (e.g. asthma medicines and hormonal contraception).

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control group<br>Healthy control subjects | Diagnostic Test: Hyperinsulinemic euglycemic clamp<br>* Hyperinsulinemic euglycemic clamp to detect insulin sensitivity<br>|
| Atopic dermatitis/eczema group<br>Patients with atopic dermatitis | Diagnostic Test: Hyperinsulinemic euglycemic clamp<br>* Hyperinsulinemic euglycemic clamp to detect insulin sensitivity<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Insulin Sensitivity Difference Between Patients With Atopic Dermatitis and Controls | The outcome is determined by measuring the glucose necessary to maintain euglycaemia during increased insulin levels generated by continuous insulin infusion (measured as the M-value: the rate of glucose infused is equal to the rate of whole-body glucose disposal or metabolizable glucose (M) and reflects the amount of exogenous glucose necessary to fully compensate for the hyperinsulinemia) | Baseline, plasma glucose every 5 minutes, insulin/C-peptide, glucagon every 10-15 minutes throughout a 3 hour hyperinsulinaemic euglycaemic clamp |