linjc16/ctgov huggingface dataset:
The Evaluation and Management of Patients With Acute Chest Pain in China

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to describe the characteristics, evaluation, management and outcomes of acute chest pain, and to provide opportunities for future initiatives to improve the emergency care for patients experiencing acute chest pain in China.

Official Title
-----------------
The Evaluation and Management of Patients With Acute Chest Pain in China

Conditions
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Chest Pain, Acute Coronary Syndrome

Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: Acute chest pain(pain in the area inferior to the clavicle, superior to the rib arch, and anterior to the bilateral posterior axillary line）; Possible Acute Coronary Syndrome; Symptoms occurring within last 24 hours; Informed consent from patient or next of kin. Exclusion Criteria: Arrhythmia or heart failure not cause by myocardial ischemia; Confirmed lung disease without chest pain; No onset of symptoms within last 24 hours; No written consensus.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| in-hospital mortality |  | During hospital stay,an expected average of 7 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time between symptom onset and hospital admission |  | Time interval from symptom onset to arrival at the Emergency Department，an expected median of 9 hours | 
| Major adverse cardiac events (MACE) | Composite of major adverse cardiac events (MACE) including death, myocardial infarction and/or revascularization | 1 year | 
| Cost-Effectiveness Analysis | To study the cost-effectiveness ratios of diagnostic and management strategies for patients with acute chest pain | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
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Chest Pain, Acute Coronary Syndrome, Cardiac, Emergency Department, Cardiac Testing, Healthcare Utilization, Patient Centered Outcomes, Shared Decision Making, Unnecessary hospital admissions, Decision Aid
Serratus Block Versus Paravertebral Block for Post Thoracotomy Pain Relief

Study Overview
=================
Brief Summary
-----------------
This double-blinded, randomized controlled study was done on 60 patients older than 18 years undergoing thoracotomy. Patients were allocated into two equal groups (30 patients each). Group S: Standard anesthesia in addition to SPB. II. Group P: Standard anesthesia in addition to PVB.

Official Title
-----------------
Serratus Anterior Plane Block Versus Paravertebral Plane Block for Post Thoracotomy Pain Relief: A Comparative Study

Conditions
-----------------
Post Operative Pain

Intervention / Treatment
-----------------
* Procedure: Standard anesthesia in addition to serratus plane block
* Procedure: Standard anesthesia in addition to para-vertebral block


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients more than 18 ys undergoing thoracotomy operation Exclusion Criteria: morbid obesity (Body mass index > 40) impossibility of anatomical structures US identification in a satisfactory way opioids treatment before surgery or substance abuse, sepsis and/or infection at the puncture sites

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Standard anesthesia in addition to serratus plane block<br>general anesthesia was given then ultrasound-guided serratus plane block | Procedure: Standard anesthesia in addition to serratus plane block<br>* a US-guided SPB was performed after induction of general anesthesia with the patient lying supine.<br>|
| Active Comparator: Standard anesthesia in addition to para-vertebral block<br>general anesthesia was given then ultrasound-guided para-vertebral block | Procedure: Standard anesthesia in addition to para-vertebral block<br>* Standard anesthesia in addition to para-vertebral block<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prevention of post-operative pain | reduction of visual analogue score | 72 hours | 
| reduction of analgesic requirement |  | 72 hours |
Comparison of Two Identical NN1250 Formulations in Healthy Volunteers

Study Overview
=================
Brief Summary
-----------------
This trial is conducted in Europe. The aim of this clinical trial is to investigate if two identical formulations of NN1250 (insulin degludec, IDeg) have the same level of drug exposure to the body.

Official Title
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A Trial to Test for Bioequivalence Between Identical NN1250 Formulations, IM1 and IM2, in Healthy Subjects

Conditions
-----------------
Diabetes, Healthy

Intervention / Treatment
-----------------
* Drug: insulin degludec
* Drug: insulin degludec


Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: Considered generally healthy upon completion of medical history, physical examination, vital signs and electrocardiogram (ECG), as judged by the Investigator Body mass index 18.0-27.0 kg/m^2 (both inclusive) Exclusion Criteria: Subject who has donated any blood or plasma in the past month or more than 500 mL within 3 months prior to screening Smoker (defined as a subject who is smoking more than 5 cigarettes or the equivalent per day) Not able or willing to refrain from smoking and use of nicotine gum or transdermal nicotine patches during the inpatient period Female of childbearing potential who is pregnant, breast-feeding or intends to become pregnant or is not using adequate contraceptive methods (adequate contraceptive measures include sterilisation, hormonal intrauterine devices, oral contraceptives, sexual abstinence or vasectomised partner)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: IDeg (M) IM1<br> | Drug: insulin degludec<br>* Each subject will be allocated to 2 single doses of trial product on 2 separate visits: One injection with formulation 1 and and one injection with formulation 2). Injected subcutaneously (under the skin).<br>|
| Experimental: IDeg (M) IM2<br> | Drug: insulin degludec<br>* Each subject will be allocated to 2 single doses of trial product on 2 separate visits: One injection with formulation 1 and and one injection with formulation 2). Injected subcutaneously (under the skin).<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Area under the Insulin Degludec concentration-time curve |  | From 0 to 120 hours after single-dose | 
| Maximum observed Insulin Degludec concentration |  | From 0 to 120 hours after single-dose | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Area under the Insulin Degludec concentration-time curve |  | From 0 to infinity after single-dose |
Follicular Fluid, Bioavailable Vitamin D and Embryo Quality Markers

Study Overview
=================
Brief Summary
-----------------
To determine the correlation between bioavailable Vitamin D values and euploid status of the embryos in larger size follicles from UAE women undergoing in vitro fertilization procedures.

Detailed Description
-----------------
To study the possible correlation between bioavailable vitamin D values in follicular fluid and embryo quality markers. To correlate bioavailable Vitamin D values in follicular fluid from large size follicles with embryo euploid status as our main objective. Secondly, looking at morphokinetics and mitochondrial content of these embryos. Taking into account that most of UAE patients have deficiency or insufficiency of Vitamin D, if there is a correlation found we will understand better the underlying mechanism by which bioavailable Vitamin D levels may be affecting embryo quality, therefore IVF outcomes.

Official Title
-----------------
Correlation Between Follicular Fluid Levels of Bioavailable Vitamin D and Embryo Quality Markers: Euploid Status, Morphokinetics and Mitochondrial DNA Content Among UAE Women Undergoing an IVF Cycle

Conditions
-----------------
Vitamin D Deficiency

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Women´s Age >18 - ≤43 years. BMI 19-33 Male partner will produce fresh sperm sample on the same day of the egg collection procedure. Women with more than 10 follicles at the time of the trigger At the time of egg retrieval, at least three follicles between 14-<17 mm and three follicles ≥17 mm. Women ≤35 years old stimulation with rFSH antagonist Women ≥36 years old stimulation with highly-purified human menopausal gonadotropins (hpHMG) specifically for the additional LH. Middle East population Exclusion Criteria: Polycystic ovarian syndrome (according to the Rotterdam Criteria). Patients at risk of OHSS, according to the criteria previously described by Papanikolau et al. (23). History of endometriosis, classified according to the American Fertility Society (AFS) as stage 3 or more. Severe male factor definition (<2 million of sperm per ml of ejaculate) Recurrent miscarriage (3 miscarriages) Smokers History of chemotherapy or radiotherapy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 48 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vitamin D values in follicular fluid and embryo quality markers among UAE women undergoing an IVF cycle | A correlation between vitamin D levels and embryo development patterns | 6-10 months |
Study Evaluating How Quickly And To What Extent The 14-Carbon-SAM-531 Is Absorbed/Converted/Eliminated In Male Subjects

Study Overview
=================
Brief Summary
-----------------
The objective of this study is to investigate how quickly and to what extent the 14-Carbon labeled SAM-531 is absorbed into the bloodstream, converted and eliminated from the body after oral administration in healthy male subjects. As 14-Carbon labeled SAM-531 is radioactive, this enables the compound to be traced in blood, urine and feces.

Official Title
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An Open-Label, Single-Dose, Nonrandomized Study Of The Mass Balance And Metabolic Disposition Of Orally Administered 14C-Labeled SAM-531 In Healthy Male Subjects

Conditions
-----------------
Alzheimer Disease

Intervention / Treatment
-----------------
* Drug: SAM-531


Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: Men aged 18 to 50 years inclusive at screening Healthy as determined by the investigator on the basis of screening evaluations Exclusion Criteria: Presence or history of any disorder that may prevent the successful completion of the study. Any significant cardiovascular, hepatic, renal, respiratory, gastrointestinal, endocrine, immunologic, dermatologic, hematologic, neurologic, or psychiatric disease.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Single oral dose | Drug: SAM-531<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Radioactivity measurements in blood, urine and feces and pharmacokinetic parameters (Cmax, AUC, terminal elimination half life, total clearance and volume of distribution in the plasma ; urine clearance ; metabolite profiling in plasma, urine and feces.) |  | 15 days |
A Comparison of General Versus Peripheral Nerve Block for Lower Extremity Amputation in Diabetic Patients With Bleeding Tendency: a Retrospective Study

Study Overview
=================
Brief Summary
-----------------
Retrospective data collection. The aim of this study is to compare general anesthesia and nerve block anesthesia with respect to the postoperative complications in patients undergoing diabetic leg amputation and having bleeding tendency.

Official Title
-----------------
A Comparison of General Versus Peripheral Nerve Block for Lower Extremity Amputation in Diabetic Patients With Bleeding Tendency: a Retrospective Study

Conditions
-----------------
Daibetic Foot

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1.Adults patients ≥20 years who underwent lower extremity amputation for diabetic foot under general anesthesia or PNB and having coagulopathy in which condition that neuraxial block is contraindicated Exclusion Criteria: patients with prior surgical history within 1 month combined operation (joint operation) patients who required continuous intravenous administration of vasopressors and/or mechanical ventilation prior to surgery combination of general anesthesia and PNB

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Occurrence of major complication | Major complications included pneumonia (followed the definition of European Perioperative Clinical Outcome), myocardial infarction (followed the definition of World Health Organization), stroke (A central neurologic deficit persisting postoperatively for > 24 h), venous thromboembolism (confirmed by image study), delirium (confirmed by psychiatrist), acute kidney injury (based on Kidney Disease: Improving Global Outcomes Criteria), new requirement for dialysis, surgical site infection, Return to the OP room. | Within 1 month after the surgery | 
| Occurrence of mortality | Mortality refers all deaths. | Within 1 month after the surgery |
Gastric Emptying Using Two Imaging Methods for Those Who Have Undergone POSE2 Weight Loss Procedure

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to compare a less invasive breath test against the current standard for assessing gastric (stomach) emptying. The current standard of care is a procedure called Nuclear Scintigraphy of a Solid Meal (NSSM). This study will compare this method to a Gastric Emptying Breath Test (GEBT).

Official Title
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Direct Comparison of Short- And Long-Term Gastric Emptying By Nuclear Scintigraphy and Gastric Emptying Breath Test in Subjects Undergoing Endoscopic Gastric Remodeling For Weight Loss

Conditions
-----------------
Weight Loss

Intervention / Treatment
-----------------
* Other: NSSM and GEBT


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subjects must be 22-65 years of age at time of enrollment Subjects must already be consented to 17-007934 or 19-001254 Subject must be agreeable and compliant with study requirements, including up to three (baseline, 2 month, and 6 month) visits, as well as undergoing GEBT and NSSM testing. If female, must be post-menopausal, surgically sterile, or agree to practice a form of birth control or abstinence during year of study and have negative serum HCG at screening/baseline Must be willing and able to travel, as needed, to the Investigator's office to complete all routine follow-up visits Exclusion Criteria: Persons presently or soon to be incarcerated Females who are pregnant or suspect they may be pregnant Persons with nicotine and/or alcohol dependence Patients with cognitive impairment that limits their ability to make autonomous decisions Known allergies or sensitivities to study materials (eggs and spirulina) Assessed, by the physician or delegate, that enrollment would not be appropriate

Ages Eligible for Study
-----------------
Minimum Age: 22 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Observational<br>NSSM and GEBT | Other: NSSM and GEBT<br>* The time to half gastric emptying (T1/2) will be assessed via Gastric Emptying Breath Tests (GEBT) and Nuclear Scintigraphy of a Solid Meal (NSSM) at baseline, 2 months, and 6 months. This data will be collected from seven adult subjects, with obesity, who have recently received Endoscopic Bariatric and Metabolic Therapy.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of T1/2 | The aim of this study is to compare baseline, early post-procedural (2 month), and delayed post-procedural (6 month) T1/2, as assessed by both GEBT and NSSM, in seven adult subjects with obesity who have underwent an EGRWL procedure. | Baseline, 2 months, 6 months |
Mechanisms and Therapeutic Effects of the Relaxation Response in Elderly Hypertensive Patients

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine whether the relaxation response is more effective than attention control in reducing blood pressure and medication dosage in elderly adults with isolated systolic hypertension.

Detailed Description
-----------------
The purpose of this study is to determine whether the relaxation response is more effective than health education training (attention control) in reducing systolic blood pressure and anti-hypertensive medication elimination in elderly adults with isolated systolic hypertension.

Official Title
-----------------
Mechanisms and Therapeutic Effects of the Relaxation Response in Elderly Hypertensive Patients

Conditions
-----------------
Hypertension

Intervention / Treatment
-----------------
* Behavioral: Relaxation response


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 55 years or older currently taking at least 2 anti-hypertensive medications systolic blood pressure between 140-159 mmHg diastolic blood pressure less than 90 mmHg read and understand English access to a telephone ability to attend all study visits Exclusion Criteria: other cardiovascular disease major medical illness previous experience with any RR eliciting technique current use of:beta-agonist bronchodilators, systemic corticosteroids, anti-convulsants/psychotics, immunosuppressants, cytotoxic therapy, anabolic steroids, antidepressants (other than SSRIs), dicyclomine, bile acid binding resins, or sympathomimetic medication

Ages Eligible for Study
-----------------
Minimum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Relaxation response|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determine whether the relaxation response is more effective than a health education control in reducing blood pressure in elderly adults with isolated systolic hypertension. |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluate whether the relaxation response is more effective than a health education control to safely reduce blood pressure medications in elderly adults with isolated systolic hypertension.. |  |  |