A Better Choice for Patients Undergoing Endovascular Coil Embolization

Study Overview
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Brief Summary
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The investigators designed a double-blind, randomized placebo-controlled study to determine the effects of dexmedetomidine on the recovery characteristics of patients who were scheduled to undergo endovascular coil embolization.

Official Title
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Sevoflurane, Laryngeal Mask Airway and Single-dose Dexmedetomidine: A Better Choice for Patients Undergoing Endovascular Coil Embolization

Conditions
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Intracranial Aneurysms

Intervention / Treatment
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* Drug: sevoflurane and 0.5 μg/kg dexmedetomidine
* Drug: sevoflurane and 1 μg/kg dexmedetomidine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria:18-65 years old ASA I or ASA II patients undergoing ECE treatment for intracranial aneurysms were included. Exclusion Criteria:Patients were excluded based on the following parameters: older than 65 yrs, a history of mental illness, recent use of sedatives or analgesics and with sensation.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: sevoflurane and saline infusion<br>After induction of general anesthesia, Group S received a placebo infusion of normal saline. | |
| Experimental: sevoflurane and 0.5 μg/kg dexmedetomidine<br>After induction of general anesthesia, Group DEX1 received a single dexmedetomidine dose of 0.5 μg/kg over 10 minutes. | Drug: sevoflurane and 0.5 μg/kg dexmedetomidine<br>* After induction of general anesthesia, Group DEX1 received a single dexmedetomidine dose of 0.5 μg/kg over 10 minutes.<br>* Other names: DEX1;|
| Experimental: sevoflurane and 1 μg/kg dexmedetomidine<br>After induction of general anesthesia, Group DEX2 received a single dexmedetomidine dose of 1 μg/kg over 10 minutes. | Drug: sevoflurane and 1 μg/kg dexmedetomidine<br>* After induction of general anesthesia, Group DEX2 received a single dexmedetomidine dose of 1 μg/kg over 10 minutes.<br>* Other names: DEX2;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Observing the recovery characteristics of patients who were scheduled to undergo endovascular coil embolization. | The time from termination of the general anesthetic to the time that the patient's eyes opened. Anesthesiologists collected information on emergence agitation, postoperative nausea and vomiting for 24 hours after the surgery. | At the end of the operation and 24 hours later | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dexmedetomidine, endovascular coil embolization