Cerebrovascular Response to Acute Exercise

Study Overview
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Brief Summary
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Cerebrovascular function and peripheral vascular function will be measured in healthy young adults, before and after acute bouts of aerobic exercise at various intensities.

Detailed Description
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Acute bouts of aerobic exercise have been shown to enhance vascular reactivity of the peripheral circulation; however, the effects of a single exercise session on the cerebral circulation are unknown. This study will measure cerebrovascular function and peripheral vascular function before and after aerobic exercise at high and low intensities. The research aims are: To determine if a single bout of aerobic exercise acutely enhances cerebrovascular function To determine the effect of aerobic exercise intensity and dose on cerebrovascular function in healthy adults. To determine if the acute exercise-induced changes in cerebrovascular function are associated with acute exercise-induced changes in peripheral vascular function in healthy adults.

Official Title
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The Role of Shear Stress in the Cerebrovascular Response to Acute Exercise

Conditions
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Healthy, Physical Activity

Intervention / Treatment
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* Other: Control
* Other: Aerobic Exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Between 20-40 years old BMI < 30 kg/m2 Recreationally active Experience running on a treadmill Exclusion Criteria: Current smoker History or evidence of: hepatic disease, renal disease, hematological disease, cardiovascular disease, stroke/neurovascular disease, diabetes Taking blood pressure medication History of depression or other mood related disorders Part of a vulnerable population (e.g. pregnant women, prisoner, individuals lacking capacity to consent, etc.)

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Aerobic Exercise<br>Control: Cerebrovascular function and peripheral vascular function will be measured. Aerobic Exercise: Across four separate visits, participants will perform light intensity exercise, light intensity exercise plus an additional task, vigorous intensity exercise and vigorous intensity exercise to match the energy expenditure of light intensity exercise visit. | Other: Control<br>* Ultrasound Blood Pressure Heart Rate Oxygen Saturation<br>Other: Aerobic Exercise<br>* Ultrasound Blood Pressure Heart Rate Oxygen Saturation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cerebrovascular function | Utilize ultrasound to measure a change in blood flow velocity in response to a breathing test | Change in cerebrovascular function: measurements occur at baseline and 90 minutes post aerobic exercise to quantify magnitude of change. | 
| Peripheral vascular function | Utilize ultrasound to measure a change in brachial artery diameter in response to reactive hyperemia | Change in peripheral vascular function: measurements occur at baseline and 60 minutes post aerobic exercise to quantify magnitude of change. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Exercise, Treadmill, Vascular Function, Intensity