linjc16/ctgov huggingface dataset:
Novel Psychosocial Influences on Smoking Cessation

Study Overview
=================
Brief Summary
-----------------
Our overall research goal is to determine how these novel psychosocial factors impact cessation. This pilot study will answer how dual use of other tobacco products, direct to consumer marketing, and the new phenomenon of butting-out and relighting influences cessation, and how understanding impulsivity and task persistence could lead to new and improved behavioral interventions for tobacco dependence. Answers to these pilot questions will lead to the publication of several manuscripts and provide important feasibility data to design large, well-powered clinical trials, population-level epidemiological studies, and contribute to furthering the field of tobacco treatment.

Official Title
-----------------
Novel Psychosocial Influences on Successful Tobacco Cessation Among Treatment Seekers

Conditions
-----------------
Smoking

Intervention / Treatment
-----------------
* Other: Tobacco Dependence Treatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: smokers 18 years of age or older Exclusion Criteria: non-English speaking participants

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Treatment seekers<br> | Other: Tobacco Dependence Treatment<br>* face to face, outpatient tobacco dependence treatment based on the Public Health Service guidelines for treating tobacco use and dependence<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients who have quit smoking |  | 6 months post quit date | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Smokers, outpatient, Tobacco Dependence Treatment Program
Compare Celecoxib and Ibuprofen Sr In The Management Of Acute Pain Post Orthopedic Or Gynecological Surgery

Study Overview
=================
Brief Summary
-----------------
To validate the analgesic efficacy and safety of celecoxib compared with ibuprofen SR in the management of acute pain post orthopedic or gynecological surgery

Official Title
-----------------
A Prospective, Randomized, Double-Blind, Double-Dummy, Multi-Center Study Comparing Celecoxib and Ibuprofen Sr In The Management Of Acute Pain Post Orthopedic Or Gynecological Surgery

Conditions
-----------------
Pain, Postoperative

Intervention / Treatment
-----------------
* Drug: celecoxib and ibuprofen SR


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Undergone uncomplicated orthopedic surgery or abdominal gynecological surgery under epidural anesthesia Baseline pain intensity of more than 45 mm as measured by VAS and a severity of pain graded as moderate or severe on the categorical pain intensity scale Exclusion Criteria: A previous history of intolerance or hypersensitivity to any NSAIDs, cyclooxygenase inhibitor, sulfonamides, or any analgesic, or to drugs with similar chemical structures

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: celecoxib and ibuprofen SR|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To validate the analgesic efficacy of celecoxib compared with ibuprofen SR in the management of acute pain post orthopedic or gynecological surgery |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To validate safety of celecoxib compared with ibuprofen SR in the management of acute pain post orthopedic or gynecological surgery |  |  |
C1-Inhibitor (INH) for Refractory Antibody Mediated Renal Allograft Rejection

Study Overview
=================
Brief Summary
-----------------
This is an open-label, single arm trial in which patient who have ongoing antibody mediated rejection of a kidney transplant deemed refractory to maximal medical therapy are given the complement inhibitor C1-INH (Berinert) in an effort to protect the graft from ongoing antibody mediated injury. A maximum of 5 patients will be enrolled.

Official Title
-----------------
Use of C1-INH (Berinert) for Renal Allograft Salvage in Refractory Antibody Mediated Rejection

Conditions
-----------------
Antibody Mediated Rejection of Kidney Transplant

Intervention / Treatment
-----------------
* Drug: C1-INH (Berinert)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Kidney transplant with acute antibody mediated rejection refractory to standard therapy Exclusion Criteria: Patients with known intolerance of or anaphylaxis to Berinert

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Berinert treatment<br> | Drug: C1-INH (Berinert)<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Renal Allograft Survival Measured by Severe and Refractory Antibody Mediated Renal (AMR) | number of patients that presented with severe and refractory Antibody Mediated Renal (AMR) following kidney transplant and survived beyond one year after study drug administration | 24 months |
Pilot Study About Tamoxifen Therapy for Breast Cancer Patients

Study Overview
=================
Brief Summary
-----------------
The aim of this study are to to evaluate the knowledge and understanding on tamoxifen theraphy for breast cancer patients and examine the decision conflict scale and satisfaction with decision scale while making decision to take tamoxifen.

Detailed Description
-----------------
The knowlege questionnaire about tamoxifen was developed by the medication guides that provide for patients taking tamoxifen and hormone therapy for breast cancer fact sheet from National Cancaer Institute. Several experts in the field of breast cancer and gynecologic cancer are going to review and indicate the questionnaire.

Official Title
-----------------
Pilot Study to Evaluate the Knowledge and Understanding on Tamoxifen Therapy for Breast Cancer Patients

Conditions
-----------------
Breast Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The breast cancer patients who take tamoxifenExclusion Criteria: Exclusion criteria The patients who do not agree to participate in this study The paitents who have trouble with understanding and reading Korean.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| breast cancer group<br>Taking tamoxifen | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The knowledge questionnaire about tamoxifen | There are no more follow up except one time | The study outcome measure will be assessed by face-to-face, one time. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Decision Conflict Scale | There are no more follow up except one time. | The study outcome measure will be assessed by face-to-face , one time. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Tamoxifen, Breast cancer, Knowkedge
MPV and NLR as Predictors of SBP Diagnosis

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to investigate the clinical utility of mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) as diagnostic markers for spontaneous bacterial peritonitis (SBP).

Official Title
-----------------
Mean Platelet Volume (MPV) and Neutrophil to Lymphocyte Ratio (NLR) as Predictors of Spontaneous Bacterial Peritonitis in Cirrhotic Patients

Conditions
-----------------
Spontaneous Bacterial Peritonitis

Intervention / Treatment
-----------------
* Diagnostic Test: Measurement of mean platelet volume (MPV) and blood neutrophil to lymphocyte ratio (NLR)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Decompensated liver cirrhosis ascetic patients. Exclusion Criteria: Immunocompromised patients. Patients who had received antibiotics before hospital admission. Patients on anticoagulant medications, NSAIDs, or oral contraceptive drugs. Patients with heart failure, diabetes mellitus, hypertension, hyperlipidemia, peripheral vascular disease, hematological disorders, and neoplastic disorders and patients with clinically overt hypothyroidism or hyperthyroidism or with clinically and laboratory-evident autoimmune diseases.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1<br>Ascetic patients without spontaneous bacterial peritonitis | Diagnostic Test: Measurement of mean platelet volume (MPV) and blood neutrophil to lymphocyte ratio (NLR)<br>* MPV and NLR are easily accessible and inexpensive tests<br>|
| Group 2<br>Ascetic patients with spontaneous bacterial peritonitis | Diagnostic Test: Measurement of mean platelet volume (MPV) and blood neutrophil to lymphocyte ratio (NLR)<br>* MPV and NLR are easily accessible and inexpensive tests<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The utility of MPV as non-invasive predictor of SBP | It will be measured from CBC | 1 year | 
| The utility of NLR as non-invasive predictor of SBP | It will be measured from CBC | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Spontaneous bacterial peritonitis, Mean platelet volume, Neutrophil to lymphocyte ratio
A Survey on the Cognition and Use of Intraosseous Access Among Medical Staff

Study Overview
=================
Brief Summary
-----------------
A Survey on the Cognition and Use of Intraosseous Access among Emergency Medical Staff, which is based on the platform of WJX.CN, from January 5, 2018 to January 23, 2018, via local emergency-related academic organizations to emergency medical staff throughout the country. There are 3 sections in the questionnaire: the demographic information of the participants; cognition levels and clinical use of IO; barriers and attitudes towards clinical use of IO including willingness, confidence and training demand.

Detailed Description
-----------------
This research is a cross-sectional survey research, using the method of network survey, with domestic emergency medicine medical staff as the research object. Inclusion criteria: 1) Emergency medical staff who have a Chinese medical practitioner certificate or a nurse practitioner certificate and are within the valid registration period; 2) Agree to participate in this study. Exclusion criteria: incomplete questionnaires. The questionnaire was designed for the Survey of Current Status of Marrow Cavity Pathway Cognition of Medical Staff in Emergency Department, including three parts: (1) general information of the survey object; (2) cognition and use status of IO; (3) clinical application of IO Attitude. Based on the Questionnaire Star platform, questionnaires are distributed through various emergency-related academic organizations. The front page of the questionnaire clearly marked the reminder of voluntary participation in the survey and related declarations, and it could be filled out after informed consent.

Official Title
-----------------
A Survey on the Cognition and Use of Intraosseous Access Among Emergency Medical Staff

Conditions
-----------------
Intraosseous Access

Intervention / Treatment
-----------------
* Other: no drug and device


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1) Emergency medical staff who have a Chinese medical practitioner certificate or a nurse practitioner certificate and are within the valid registration period; 2) Agree to participate in this study. Exclusion Criteria: incomplete questionnaires.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: no drug and device|there is no intervention|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognition levels and clinical use of IO | Cognitive level is divided into: never heard of, heard of, equipped, used | two weeks |
Cytogenetic and Molecular Genetic Studies in Bone Sarcomas

Study Overview
=================
Brief Summary
-----------------
To establish a serial ascertainement of specimens from patients with bone sarcomas to be used in ongoing cytogenetic and molecular genetic analyses. These data will be integrated and correlated with the established Orthopaedic Service clinical database.

Official Title
-----------------
Cytogenetic and Molecular Genetic Studies in Bone Sarcomas

Conditions
-----------------
Lung Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients must be undergoing diagnostic biopsy or resection of their primary or metastatic bone sarcoma for therapeutic purposes. The specimen must be large enough to allow routine pathological analysis, with the specimen for research excised from residual tissue that would otherwise be discarded. Exclusion Criteria: N/A
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To establish a serial ascertainement of specimens from patients with bone sarcomas to be used in ongoing cytogenetic and molecular genetic analyses. |  | conclusion of study | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Bone, Soft Tissue
Predictive Value of Mid-luteal Serum Progesterone Levels in Egg Donation Cycles

Study Overview
=================
Brief Summary
-----------------
This study aims to investigate the impact of serum progesterone concentrations on the day of embryo transfer in egg donation cycles under hormonal replacement therapy. As secondary outcomes, the investigators will investigate if endometrial volume measured by three-dimensional (3D) ultrasound on the day of embryo transfer is related with progesterone levels and with chances of pregnancy.

Official Title
-----------------
Impact of Serum Progesterone Levels on the Day of Embryo Transfer on the Success Rate in Egg Donation Cycles Under Hormonal Replacement

Conditions
-----------------
Pregnancy

Intervention / Treatment
-----------------
* Other: Progesterone 25-75
* Other: Progesterone <25, >75


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age<50 yo BMI < 30Kg/m2 Hormonal replacement cycle Endometrial thickness >6.5 mm during proliferative phase Transfer of one or two blastocyst grade A-B according to ASEBIR Exclusion Criteria: Uterine pathology Cryptozoospermia Severe implantation failure (>6 GQ embryos transferred without success)

Ages Eligible for Study
-----------------
Minimum Age: 25 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| P25-P75<br>serum progesterone between 25 and 75 percentile | Other: Progesterone 25-75<br>* Impact of serum progesterone concentrations [25-75] on the day of embryo transfer in egg donation cycles under hormonal replacement therapy<br>|
| <P25 ó >P75<br>serum progesterone <25 or >75 percentile | Other: Progesterone <25, >75<br>* Impact of serum progesterone concentrations (<25, >75) on the day of embryo transfer in egg donation cycles under hormonal replacement therapy<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mid-luteal serum progesterone level |  | one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| endometrial volume |  | one year |
Clinical Evaluation of Two Low-shrinkage Composites

Study Overview
=================
Brief Summary
-----------------
Patients with 4 occlusal lesions in molar teeth will be included. Occlusal cavities will be prepared either by Er,Cr:YSGG laser (LS) or conventional diamond bur (BR). Cavities will be restored with Filtek Silorane (3M-ESPE) (SR) and with Kalore (GC) (KR) according to the manufacturers' instructions. All restorative procedures will be performed by one operator and the restorations will be examined by two evaluators according to the FDI (World Dental Federation) criteria at baseline and at 6-month, 1-, 2-,3-, 4-, 5-, 6-, 7-, 8-, 9-, 10-year. Patients' satisfaction about the preparation methods will be evaluated with a survey. Pearson Chi-Square test will be used for statistical analyze(p=0.05).

Official Title
-----------------
Clinical Evaluation of Two Low-shrinkage Composites After Different Preparation Techniques

Conditions
-----------------
Tooth Diseases

Intervention / Treatment
-----------------
* Device: Restorative materials- Filtek Silorane
* Device: Restorative materials-Kalore
* Device: Preparation-Er,Cr:YSGG Laser
* Device: Preparation- Diamond Bur


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age range will be 18 to 60 patients should have at least 4 occlusal caries lesions require restoration healty periodontal status a good likelihood of recall availability Exclusion Criteria: poor gingival health adverse medical history potential behavioral problems

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Filtek Silorane-Er,Cr:YSGG Laser<br> | Device: Restorative materials- Filtek Silorane<br>* Filtek Silorane<br>Device: Preparation-Er,Cr:YSGG Laser<br>* Er,Cr:YSGG Laser<br>|
| Experimental: Filtek Silorane- Diamond Bur<br> | Device: Restorative materials- Filtek Silorane<br>* Filtek Silorane<br>Device: Preparation- Diamond Bur<br>* Bur<br>|
| Experimental: Kalore- Er,Cr:YSGG Laser<br> | Device: Restorative materials-Kalore<br>* Kalore<br>Device: Preparation-Er,Cr:YSGG Laser<br>* Er,Cr:YSGG Laser<br>|
| Experimental: Kalore- Diamond Bur<br> | Device: Restorative materials-Kalore<br>* Kalore<br>Device: Preparation- Diamond Bur<br>* Bur<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical performance of different low-shrinkage composites and preparations | Evaluations according to FDI criteria | 10 years |
Treatment of Severe Limb Ischemia With Autologous Bonemarrow Derived Mononuclear Cells

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to investigate whether implantation of autologous bone marrow derived stem cells in ishemics limbs will improve vascularization

Detailed Description
-----------------
10 patients with severe lower limb ischemia will be included in this pilote trial. Bonemarrow aspiration will be performed and and the monocuclear cells isolated an injected into the gastrocnemius. The patiens are followed for 4 months. Were trancutaneous oxygenpressure, ankel and toe blood pressure is measured.

Official Title
-----------------
Treatment of Severe Limb Ischemia With Autologous Bonemarrow Derived Mononuclear Cells

Conditions
-----------------
Ischemia

Intervention / Treatment
-----------------
* Procedure: Stem cell implantation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Ankle blood pressure < 70 mmgHG Either pain at rest and/or ischemic wound No possible surgical treatment Exclusion Criteria: Infection Malignant disease

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Stem cell implantation|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Transcutaneous oxygen pressure |  |  | 
| 1st toe blood pressure (strain gauge) |  |  | 
| Ankle blood pressure |  |  | 
| Wound healing |  |  | 
| Pain |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| amputation |  |  | 
| Infection |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
CLI, PAOD, Severe lower limb ischemia