Epidemiologic and Clinical Characteristics of Optic Neuritis in China

Study Overview
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Brief Summary
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This will be a hospital-based retrospective multi-center study on epidemiologic and clinical characteristics of optic neuritis among Chinese. The investigation will cover about 29 provinces or municipalities all around China.

Detailed Description
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This national investigation will be conducted to describe the epidemiology and clinical characteristics of optic neuritis in China. All the patients will be divided into 3 groups according to the serum demyelinating antibodies (Aquaporin-4 antibody seropositive group, Myelin oligodendrocyte glycoprotein antibody seropositive group and double seronegative group). The investigator will analyze the differences among the three groups. Primary outcomes: To dig out the different visual acuity (VA, LogMAR) prognosis among the three groups; To calculate the annual relapse rate (ARR) differences among the three groups (relapse times in all the follow-up time in each group/ follow-up time (years) in all in each group). Secondary outcomes: Other epidemiological and clinical characteristics of optic neuritis patients will be analyzed among the three groups; Orbital or Brain MRI is required in this study, which could avoid the misdiagnosis. We will collect and analyze these MRI data too (including the optic nerve lesions in T2 weight images and T1 enhanced MRI); Results of optical coherence tomography (OCT) (including peripapillary retinal nerve fiber layer, macular thickness ,and ganglion cell and inner plexiform layer complex) at different time point are also needed in this study. However, OCT is not necessarily required; Visual fields at different time points are also encouraged to provide if they are available.

Official Title
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Epidemiologic and Clinical Characteristics of Optic Neuritis in China

Conditions
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Optic Neuritis

Intervention / Treatment
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* Other: observation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical diagnosis of optic neuritis The patients' medical records were complete Exclusion Criteria: Patients with unclear diagnosis of optic neuritis Incomplete medical records
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| optic neuritis<br>Aquaporin 4 antibody seropositive optic neuritis patients, Myelin oligodendrocyte glycoprotein antibody seropositive optic neuritis patients, and double antibodies seronegative optic neuritis patients | Other: observation<br>* different serum antibodies status<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual Acuity | Last visual acuity records in the hospital | At least 1 year from the attack to the final visit | 
| Annual Relapse Rate | Calculated annual relapse rate of different subgroups in the cohort | At least 1 year from the attack to the final visit | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Epidemiologic characteristics of optic neuritis | Gender, age of first attack, location | At least 1 year from the attack to the final visit | 
| Clinical characteristics of optic neuritis | Visual acuity at nadir, pain, optic disc edema | At least 1 year from the attack to the final visit | 
| Optical Coherence Tomography | RNFL, macular thickness and GCIPL at different time points | At least 1 year from the attack to the final visit | 
| Orbit or Brain MRI at the attack | Lesions of the optic nerve | At least 1 year from the attack to the final visit | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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optic neuritis, clinical Characteristics, epidemiology