Study of Tissue Samples From Patients With Non-Small Cell Lung Cancer

Study Overview
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Brief Summary
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RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies tissue samples from patients with non-small cell lung cancer.

Detailed Description
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OBJECTIVES: To identify and characterize single nucleotide variations (SNVs) in non-small cell lung cancer (NSCLC) specimens. To identify and characterize structural variations in the genomes of NSCLC specimens. To identify and characterize other genomic alterations including, but not limited to, expression profiling and methylation. OUTLINE: DNA and RNA extracted from archived specimens are analyzed for single nucleotide variations, structural variations in the genomes, and other genomic alterations including, but not limited to, gene expression profiling and methylation. Clinical data related to disease, treatment, and recurrence from each patient sample is also collected.

Official Title
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Molecular Characterization of Lung Cancer: A Collaboration With the Cancer Genome Atlas Project (TGCA)

Conditions
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Lung Cancer

Intervention / Treatment
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* Genetic: DNA analysis
* Genetic: DNA methylation analysis
* Genetic: RNA analysis
* Genetic: gene expression analysis
* Genetic: polymorphism analysis
* Other: laboratory biomarker analysis
* Other: medical chart review


Participation Criteria
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Eligibility Criteria
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Patient must have been registered to CALGB 140202. Tumor histology should be either primary adenocarcinoma or squamous cell carcinoma of the lung. Patients are eligible for this study if their samples from CALGB 140202 are available. All living patients must sign the CALGB 151107 consent form to be eligible for this trial.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1<br>CALGB 140202 outlines the standard procedures for sample procurement. Samples to be used for this project have already been obtained and are currently banked at the CALGB Pathology Coordinating Office (PCO) and the Lung Cancer Tissue Bank at Brigham and Women's Hospital. | Genetic: DNA analysis<br> <br> Genetic: DNA methylation analysis<br> <br> Genetic: RNA analysis<br> <br> Genetic: gene expression analysis<br> <br> Genetic: polymorphism analysis<br> <br> Other: laboratory biomarker analysis<br> <br> Other: medical chart review<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Identification and characterization of SNVs in primary adenocarcinoma of the lung or squamous cell carcinoma of the lung |  | up to 5 years | 
| Identification and characterization of structural variations in the genomes of NSCLC |  | up to 5 years | 
| Identification and characterization of other genomic alterations including, but not limited to, gene expression profiling and methylation |  | up to 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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adenocarcinoma of the lung, adenosquamous cell lung cancer, non-small cell lung cancer, squamous cell lung cancer