Memory Inhibition and Delayed Onset Post-traumatic Stress Disorder in Older Subjects

Study Overview
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Brief Summary
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In the elderly, we can see a post-traumatic syndrome associated with an event that occurred before old age that had not previously manifested or not fully manifested. This little-known pathology and notable psychiatric co-morbidities (depression, anxiety) can take in elderly subjects different masks that interfere with diagnosis and treatment. The data in the literature suggest that this Post-Traumatic Stress Disorder with Delayed Expression (TSPT-R) may be related to a deficiency of the executive functions of inhibition, and more particularly a deficit of mental memory inhibition and therefore the removal of unwanted memories.

Official Title
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Memory Inhibition and Delayed Onset Post-traumatic Stress Disorder in Older Subjects

Conditions
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Post-Traumatic Stress Disorder in Old Age

Intervention / Treatment
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* Other: Post Traumatic Stress Disorder


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Regarding the constitution of the group patient (TSPT-R): Subjects 65 years of age or older Clinical diagnosis of delayed-onset PTSD according to DSM-5 criteria after 65 years The traumatic event must have taken place at the latest before 65 years Affiliated person or beneficiary of a social security scheme. Written consent before any examination required by research) Regarding the constitution of the control group: Subjects 65 years of age or older No diagnosis of PTSD (delayed or not) or history of PTSD (delayed or not) Affiliated person or beneficiary of a social security scheme. Written consent before any examination required by the research). Exclusion Criteria: For both groups: Acute or chronic cognitive impairment known GRECO MMSE pathological score less than or equal to the pathological threshold weighted according to level of education and age, namely: 22 if no diploma 23 if certificate of study 25 if patent 26 if bin or more Remove one point at each threshold if age> 80 years Sensory or motor disorder preventing the passing of different tests Psychotic disorder Mood disorder in decompensation (for depression, HAD-D score equal to or greater than 11) Disorder of the use of a moderate or severe substance (except tobacco). Patients under guardianship or curatorship.

Ages Eligible for Study
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Minimum Age: 65 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Patient (TSPT-R)<br>Post Traumatic Stress Disorder | Other: Post Traumatic Stress Disorder<br>* The test Think / No-Think<br>|
| Experimental: control<br>No Post Traumatic Stress Disorder | Other: Post Traumatic Stress Disorder<br>* The test Think / No-Think<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Inhibition score measured by the Think / No-Think Test | the average of the inhibition score measured by the Think / No-Think test as defined by Anderson and Green (2001) and then reviewed by Anderson et al. in 2011 | 1 month |