Subclinical Cardiac Involvement in Patients With Inflamatory Bowel Disease

Study Overview
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Brief Summary
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Aim of the study is to determine the prevelance of subclinical cardiac involvement in patients with inflamatory bowel disease.

Detailed Description
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Cardiovascular manifestations in patients with IBD mostly occur as immune-related consequences and include the following: pericarditis, myocarditis, venous and arterial thromboembolism, left ventricle impairment, arrhythmias and conduction disorders and valvulopathy . The prevalence of classical cardiovascular risk factors is relatively lower in IBD patients than in the general population . However, the risk of coronary heart disease is higher in IBD patients . The pathophysiology of cardiac involvement may be Systemic inflammation for prolonged periods that can cause platelet aggregation and endothelial dysfunction leading to the development of atherosclerosis and CVD . The chronic inflammatory condition found in IBD is the key element in the pathogenesis of arrhythmias. In IBD, inflammation causes mitral and aortic valvulopathies , excess TNF-α causes the thickening and shortening of the leaflets, resulting in regurgitation . Medications of IBD may be involved in pathogenesis of cardiac involvement as follows 5-ASA and its derivatives can cause myopericarditis . Atrial fibrillation and prolonged QT interval may occur during azathioprine use . Cyclosporine is associated with increased risk of hypertension, arrhythmias, acute coronary syndrome, and heart failure . Biological molecules are associated with increased arrhythmogenic risks . Primary preventive measures of arterial thromboembolism include maintaining the remission, strict control of cardiovascular risk factors . The diagnostic modalities to find out cardiac involvement include; The 12-lead electrocardiogram . Transthoracic echocardiography which represent the method of choice to evaluate both systolic and diastolic functions of Lt ventricle. Methodology: All Patints will be subjected to the followings : Full history taking including Duration of illness Symptoms of disease activity Symptoms of extraintestinal manifestation Family history of cardiac disease History of traditional cardiovascular risk factors diabetes,hypertension,Dyslipidaemia,cigarette smooking) Therapeutic history Examination Body mass index. Vital signs( pulse,blood pressure,temperature). Cardiac examination. Labaratory investigations Complete blood count - serum electrolytes ESR - CRP lipid profile - blood glucose level TSH,T3,T4 ECG Ischaemic changes Any type of arrythmia Prolonged QT interaval Holter ECG Echocardiography Systolic and diastolic dysfunctions Wall motion abnormalities Valvular heart disease Ventricular hypertrophy Atrial and ventricular dimentions

Official Title
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Subclinical Cardiac Involvement in Patients With Inflamatory Bowel Disease

Conditions
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Inflammatory Bowel Diseases

Intervention / Treatment
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* Device: ECG, HolterECG ,Echocardiography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Inflamatory bowel disease patients without previous history of cardiac disease. Exclusion Criteria: Patients known to have previous cardiac disease.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: ECG, HolterECG ,Echocardiography|ECG, HolterECG ,Echocardiography to determine any type of arrythmia,ischaemic heart disease,valvular heart disease,systolic and diastolic dysfunction|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| determine the prevelance of cardiac involvement in inflamatory bowel disease | Assesment of cardiac involvement in inflamatory bowel disease byECG,HolterECG andEchocardiography | Baseline |