SMS Reminders to Strengthen Demand for HPV Vaccination in Georgia

Study Overview
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Brief Summary
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It is possible that achieving adequate HPV vaccination coverage will allow cervical cancer to be virtually eliminated. This is a priority for Georgia, where the burden of mortality and morbidity from cervical cancer is high and the yearly prevalence of cervical cancer is 14.5 per 100,000 population. The objective of the intervention evaluated is to increase the uptake of the 1st dose of the HPV vaccination in Georgia. The intervention aims to achieve this by providing a SMS reminder informed by behavioural insights (BI) to remind caregivers of girls between 10-12 years that their daughter is due the first dose of her HPV vaccination, share information about the vaccine, and encourage them to book an appointment to receive the vaccination. Four different SMS messages will be compared to no SMS message. The evaluation will be a 5-arm randomised controlled trial (RCT) which aims to answer the research question: Does each of the designed BI-informed SMS reminders increase the uptake of the first dose of the HPV vaccination among eligible girls in Georgia, compared to no reminder? Our hypothesis is that SMS reminders will increase the uptake of HPV vaccination.

Official Title
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Design, Test and Evaluate Behavioural Insights Interventions to Strengthen Demand for Immunisation in Georgia

Conditions
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HPV, Human Papillomavirus Viruses, Human Papilloma Virus Vaccine

Intervention / Treatment
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* Behavioral: SMS reminder for the HPV vaccination


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Girls Aged 10-12 years Not yet received any doses of the HPV vaccine With a caregiver's mobile phone number in the e-health system. Exclusion Criteria: Boys Girls aged less than 10 or more than 12 years Girls with no caregiver phone number in the e-health system Girls who have received 1 or 2 doses of the HPV vaccine

Ages Eligible for Study
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Minimum Age: 10 Years
Maximum Age: 12 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: No SMS reminder<br>This group will receive no reminder | |
| Experimental: Short SMS with no additional information<br>Caregivers of girls eligible to receive the HPV vaccination in this group will receive an SMS reminder that states: As per national immunization calendar your daughter is due her free human papilloma virus vaccine, which will protect her against cervical cancer. Contact your family doctor today to arrange an appointment. | Behavioral: SMS reminder for the HPV vaccination<br>* A BI-informed SMS reminder to remind caregivers of girls between 10-12 years that their daughter is due the first dose of her HPV vaccination and share information about the vaccine.<br>|
| Experimental: Short SMS + NCDC link<br>Caregivers of girls eligible to receive the HPV vaccination in this group will receive an SMS reminder that states: As per national immunization calendar your daughter is due her free human papilloma virus vaccine, which will protect her against cervical cancer. Contact your family doctor today to arrange an appointment. More information on the official NCDC website | Behavioral: SMS reminder for the HPV vaccination<br>* A BI-informed SMS reminder to remind caregivers of girls between 10-12 years that their daughter is due the first dose of her HPV vaccination and share information about the vaccine.<br>|
| Experimental: SMS with reserved for her framing + NCDC link<br>Caregivers of girls eligible to receive the HPV vaccination in this group will receive an SMS reminder that states: As per national immunization calendar your daughter is due her free human papilloma virus vaccine, which will protect her against cervical cancer. Her vaccine is reserved at the policlinic. Contact your family doctor today to arrange an appointment. More information on the official NCDC website | Behavioral: SMS reminder for the HPV vaccination<br>* A BI-informed SMS reminder to remind caregivers of girls between 10-12 years that their daughter is due the first dose of her HPV vaccination and share information about the vaccine.<br>|
| Experimental: SMS with safety information + NCDC link<br>Caregivers of girls eligible to receive the HPV vaccination in this group will receive an SMS reminder that states: As per national immunization calendar your daughter is due her free human papilloma virus vaccine, which will protect her against cervical cancer. The vaccine has been given safely to more than 118 million girls worldwide. Contact your family doctor today to arrange an appointment. More information on the official NCDC website | Behavioral: SMS reminder for the HPV vaccination<br>* A BI-informed SMS reminder to remind caregivers of girls between 10-12 years that their daughter is due the first dose of her HPV vaccination and share information about the vaccine.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HPV vaccination status | 1st dose HPV vaccination status of the caregiver's daughter | At 60 days after receiving the SMS reminder |