Stockholm Acute Kidney Injury Cohort

Study Overview
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Brief Summary
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Since 2009, adult patients with acute kindney injury (AKI) at the department of Nephrology, Danderyd University Hospital and Karolinska Institutet, have been included in a prospective cohort. All patients were treated and evaluated according to a detailed clinical memorandum, and data collected prospectively. By 2020, 1861 patiens have been included of which 1519 fulfill current AKI criteria (as defined by KDIGO AKI guidelines) and will be evaluated regarding the following main research questions: Descriptive study on patient characteristics, changes in biomarkers and in-hospital outcome. One year outcome with focus on renal and cardiovascular outcomes. Long-term outcome (up to 10 years) with focus on renal and cardiovascular outcomes.

Detailed Description
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Acure kidney injury (AKI) remains a complex clinical challenge associated with high risk for short-term and long-term adverse events. Since 2009 patients with AKI at the department of Nephrology, Danderyd University Hospital and Karolinska Institutet, have been included in a prospective cohort. Adult patients with either s-creatinine >130 micromol/L and previously unknown level, or 30% increase from previous known level were included; patients on dialysis were not included. All patients were treated and evaluated according to a detailed clinical memorandum, and data collected prospectively. By 2020, 1861 patiens have been included of which 1519 fulfill current AKI criteria and will be evaluated regarding the following main research questions: Descriptive study on in-hospital outcome (death, renal recovery), patient characteristics, hyperkalemia and changes in biomarkers reflecting inflammation, acidosis and malnutrition. One year outcome with focus on renal and cardiovascular outcomes (death, new dialysis, worsened renal function, myocardial infarction, stroke, or heart failure; MARCE). Long-term outcome (up to 10 years) with focus on renal and cardiovascular outcomes (MARCE).

Official Title
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Stockholm Prospective Acute Kidney Injury Cohort Study

Conditions
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Acute Kidney Injury

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria (one of the following): Serum creatinine (sCr) >130 µmol/l (1.47 mg/dl) at admission with previously unknown baseline, Increase in sCr by 30% from previous stable out-patient value. Exclusion Criteria: Ongoing dialysis treatment.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| In-hospital outcome | Death | From admission until discharge or death, assessed for a period of up to 3 months | 
| 1-year outcome | Descriptive study on Major Adverse Renal or Cardiovascular Events (death, new dialysis, worsened renal function, myocardial infarction, stroke, or heart failure; MARCE) | From admission until 1 year | 
| Long-term outcome | Descriptive study on Major Adverse Renal or Cardiovascular Events (MARCE) | From admission until 10 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| In-hospital partial renal recovery | Renal recovery by 30% at the time of discharge or death | From admission until discharge or death, assessed for a period of up to 3 months | 
| In-hospital renal recovery | Renal recovery by 50% at the time of discharge or death | From admission until discharge or death, assessed for a period of up to 3 months | 
| In-hospital biomarkers | Changes in biomarkers with focus on potassium, malnutrition, inflammation and acidosis | From previous values or values at admission until discharge or death, assessed for a period of up to 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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acute renal failure, hyperkalemia, major adverse cardiovascular event