Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training

Study Overview
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Brief Summary
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The purpose of this study is to examine feasibility and efficacy of the Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training (U-SMART) in the elderly individuals with mild cognitive impairment (MCI).

Detailed Description
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The Spaced Retrieval-based Memory Advancement and Rehabilitation Training (SMART) which consisted of 24 one-hour face-to-face sessions (Lee, Park et al. 2009) was developed based on the spaced retrieval training (SRT), which was effective in improving memory retention span of very mild to mild Alzheimer's disease patients. The Ubiquitous SMART (U-SMART) by transforming the current SMART to a self-administered program using an application working on IPAD was developed, and was examined its feasibility and efficacy in the elderly individuals with mild cognitive impairment.

Official Title
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Feasibility and Efficacy of the Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training (U-SMART) on Mild Cognitive Impairment

Conditions
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Mild Cognitive Impairment

Intervention / Treatment
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* Device: U-SMART


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged 55-90 Educational level above 1 year and confirmed literacy Diagnosed to mild cognitive impairment by International Working Group on Mild Cognitive Impairment Clinical Dementia Rating (CDR) of 0 or 0.5 Exclusion Criteria: Diagnosed to dementia by DSM-IV Evidence of delirium, confusion Any neurological conditions causing cognitive decline such as Parkinson's disease, brain hemorrhage, brain tumor, normal pressure hydrocephalus Evidence of severe cerebrovascular pathology History of loss-of-consciousness over 1 hour due to head trauma or repetitive head trauma of mild severity History of substance abuse or dependence such as alcohol Presence of depressive symptoms that could influence cognitive function Presence of medical comorbidities that could result in cognitive decline Use of medication that could influence cognitive function seriously

Ages Eligible for Study
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Minimum Age: 55 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: U-SMART<br>U-SMART (Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training) | Device: U-SMART<br>* 4-weeks' training<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the five-point Likert scales for satisfaction and compliance | To evaluate the feasibility of the U-SMART, the five-point Likert scales for satisfaction and compliance were applied to all participants. | after 4-weeks treatment | 
| Word List Memory Test of the CERAD Neuropsychological Assessment Battery | To evaluate the efficacy of the U-SMART, the Word List Memory Test (WLMT) of the CERAD neuropsychological assessment battery was applied to all participants. | after 4-weeks treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mini-Mental State Examination (MMSE) |  | after 4-weeks treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Mild cognitive impairment, Cognitive rehabilitation, Cognitive therapy, Spaced retrieval Training, Alzheimer's disease, Memory enhancement, U-healthcare