Desflurane Versus Propofol in the Sitting Position

Study Overview
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Brief Summary
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The investigators hypothesized that both propofol and desflurane would decrease the regional oxygen saturation (rSO2) but propofol is likely to reduce rSO2 more than sevoflurane when patients are raised to the sitting position.

Detailed Description
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The investigators hypothesized that both propofol and desflurane would decrease the rSO2 but propofol is likely to reduce rSO2 more than sevoflurane when patients are raised to the sitting position. Therefore, the purpose of this study was to investigate the effect of desflurane and propofol on rSO2 values during the beach chair position for shoulder arthroscopy.

Official Title
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International Review Board of Gachon University Gil Hospital

Conditions
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Cerebral Ischemia

Intervention / Treatment
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* Drug: propofol
* Drug: Desflurane
* Drug: alfentanil
* Drug: Rocuronium


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Forty patients, ASA class I or II, undergoing shoulder arthroscopy Exclusion Criteria: Patients with history of cerebrovascular disease, coronary occlusive disease and/or obesity (body mass index > 30) were excluded from this study.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Desflurane<br>anaesthesia was induced with thiopental sodium 2 mg kg-1, alfentanil 10 μg kg-1 and rocuronium 0.6 mg kg-1. Anesthetic maintenance by desflurane | Drug: Desflurane<br>* anaesthesia was maintained by desflurane 4-7vol%<br>* Other names: Des;Drug: alfentanil<br>* administration of alfentanil 10 μg kg-1 for anesthetic induction<br>* Other names: alf;Drug: Rocuronium<br>* administration of rocuronium 0.6 mg kg-1 for anesthetic induction<br>* Other names: roc;|
| Active Comparator: propofol<br>anaesthesia was induced with the effect-site concentration of propofol 5.0 μg ml-1, alfentanil 10 μg kg-1, and rocuronium 0.6 mg kg-1. A commercially available target controlled infusion (TCI) pump (Orchestra®, Fresenius Vial, France) was used and the pharmacokinetic set used to calculate target effect-site concentrations for propofol was Schnider and colleagues' model | Drug: propofol<br>* anaesthesia was induced with the effect-site concentration of propofol 5.0 μg ml-1 mainly.<br>Drug: alfentanil<br>* administration of alfentanil 10 μg kg-1 for anesthetic induction<br>* Other names: alf;Drug: Rocuronium<br>* administration of rocuronium 0.6 mg kg-1 for anesthetic induction<br>* Other names: roc;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Regional Cerebral Oxygen Satuation (rSO2) | definitive values of regional cerebral oxygen saturation(rSO2,%) values are described as mean (SD) | 1, 3, 5, 7, and 9 min after the beach chair position | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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propofol, desflurane, cerebrovascular circulation, sitting