Construction-LBD (Constructional Apraxia in Alzheimer's Disease (AD) and Lewy Body's Dementia (LBD))

Study Overview
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Brief Summary
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Alzheimer's disease (AD) and Lewy body's dementia (LBD) are two frequent neurodegenerative pathologies. They differ in their expression, their evolution but share same features which make their diagnosis uneasy. Constructional apraxia has been described in both disease.The underlying mechanisms have been less studied and could be different in AD and LBD. The definition of the constructional apraxia is purely descriptive and few models are inconclusive. It is admitted that drawing tasks involve visuo-perceptive and visuo-spatial abilities, executive functions and working memory as well as purely constructive skills. Regarding to different studies, visuo-perceptive abilities are more severely impaired in LBD than in AD and are considered as an early onset sign of the disease. Executive functions deficits are documented in AD and LDB and could contribute to the drawing impairment. It is possible to compensate the planning disorders in giving patient the best strategy to use. If drawing impairment persists, they should result of others mechanisms like visuo-perception, visuo-spatial or constructive deficits. The investigators suggest that giving the best planning strategy will help more AD patients who are supposed to fail in raison of an executive impairment, than the LDB group who is supposed to present visuo-perceptive deficits. An MRI will be proposed to study the cerebral areas involved in constructional apraxia.

Official Title
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Constructional Apraxia in Alzheimer's Disease (AD) and Lewy Body's Dementia (LBD)

Conditions
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Alzheimer's Disease, Lewy Body's Dementia

Intervention / Treatment
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* Other: Rey figure test
* Other: MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Alzheimer's disease or Lewy bodies dementia ≥ 45 years the cognitive impairment is mild to moderate French speaker a caregiver is present An informed consent is signed by the patient and the p.i. Exclusion Criteria: MRI contraindication Other neurological disease (FTD, brain tumor, vascular disease…) Psychiatric disease (Schizophrenia, major depression, psychotic disorders, melancholia…) Patient who doesn't want to be informed in case of the discovery of an abnormality View or audition deficits, or motor disability which can interfere with the cognitive testing Patient participating to an exclusive protocol or in the period of exclusion Pregnant woman Person under an administrative or legal measure of liberty privation Person under a legal measure of protection or under administrative supervision Person unable to give his consent

Ages Eligible for Study
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Minimum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Alzheimer's disease (AD)<br>Rey figure test and MRI | Other: Rey figure test<br> <br> Other: MRI<br> <br> |
| Experimental: Lewy body's dementia (LBD)<br>Rey figure test and MRI | Other: Rey figure test<br> <br> Other: MRI<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Score obtained at the Rey figure test with a planning strategy help by LBD patients compared to the score obtained by AD patients. |  | At inclusion |