linjc16/ctgov huggingface dataset:
Influence of Alcohol and Peer Passengers on Risky Driving Behavior in Young Adults

Study Overview
=================
Brief Summary
-----------------
Among the many risk factors that contribute to young drivers' crash involvement, two are critical: peer passenger presence, which is unique to young drivers, and the influence of alcohol, a universal risk for drivers but one against which young drivers are most susceptible. Clarification of how passenger presence interacts with alcohol consumption to increase risk is needed. The impact of experimentally manipulated passenger characteristics and alcohol quantity on risky driving is observed using driving simulation and a random assignment experimental design with a sample of 18-21 year old male and female drivers.

Official Title
-----------------
Influence of Alcohol and Peer Passengers on Risky Driving Behavior in Young Adults

Conditions
-----------------
Accidents, Traffic

Intervention / Treatment
-----------------
* Behavioral: Passenger


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: being 18 to 21 years of age (18 years old is the legal age for alcohol consumption in the province of Quebec) past experirence with drinking at least 2 alcoholic beverages in one episode having a provisional driving license driving in the past 3 months Exclusion Criteria: health problem that contraindicates participation pregnant or breastfeeding signs of problem drinking positive BAC or recent drug use measured at arrival

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: no alcohol and passenger<br>Blood alcohol concentration (BAC) = 0.00% and risk accepting or averse passenger | Behavioral: Passenger<br>* Driving with risk accepting or risk averse passenger<br>|
| Experimental: low alcohol dose and passenger<br>BAC = 0.02% and risk accepting or averse passenger | Behavioral: Passenger<br>* Driving with risk accepting or risk averse passenger<br>|
| Experimental: moderate alcohol dose and passenger<br>BAC = 0.05% and risk accepting or averse passenger | Behavioral: Passenger<br>* Driving with risk accepting or risk averse passenger<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Risky driving in a simulator |  | within 1 hr after alcohol dose | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Risk, Young drivers, Alcohol, Passengers, Gender
Clinical and Basic Study for Pediatric Liver Transplantation

Study Overview
=================
Brief Summary
-----------------
Background: In mainland China, the development of pediatric liver transplantation (LT) has lagged behind that of adult LT during the past two decades, but it has been progressing immensely in recent years. Renji hospital(shanghai) is currently the largest pediatric transplant center in mainland China. Aim and method: This study is performed for establishment of key techniques for pediatric LT in mainland China, including the indications and timing for pediatric LT, the criteria for donor selections, living donor LT planning, prevention and treatment for posttransplant complications, long-term follow-up management et al.

Detailed Description
-----------------
Outcome measures: Annual caseloads of pediatric liver transplantation Patient survival: 1-, 3- and 5-year patient survival after liver transplantation Graft survival: 1-, 3- and 5-year graft survival after liver transplantation Posttransplant complications, such as biliary complications, vascular complications, acute rejections, infections et al. Perioperative data, such as duration of operations, postoperative hospital stay et al. Clinical data for living donors.

Official Title
-----------------
Clinical and Basic Study for Pediatric Liver Transplantation

Conditions
-----------------
Biliary Atresia, Metabolic Disorders, Fulminant Liver Failure, Hepatic Tumors

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children with end-stage liver diseases Children with metabolic disorders for whom liver transplantation are required Children with fulminant liver failure Children with unresectable hepatic tumors Other miscellaneous conditions which need liver transplantation Exclusion Criteria: Recipient age ≥ 18 years Patients with metastatic liver tumors Severe systmatic infections Acquired Immune Deficiency Syndrome

Ages Eligible for Study
-----------------
Minimum Age: 1 Month
Maximum Age: 17 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient survival |  | up to 36 months | 
| Graft survival |  | up to 36 months | 
| Annual caseload for pediatric liver transplantation |  | up to 36 months |
Inion OTPS Biodegradable Fixation System for the Ankle

Study Overview
=================
Brief Summary
-----------------
The purpose of the investigation is to compare post-operative fracture and wound healing using Inion OTPS Biodegradable Fixation System implants versus Conventional metal implants.

Official Title
-----------------
A Double-Blind,Randomised,Prospective Clinical Investigation to Compare Post-Operative Fracture Healing Using the Inion OTPS Biodegradable Fixation System Versus Conventional Metal Screws and Plates in the Treatment of Ankle Fractures.

Conditions
-----------------
Surgery

Intervention / Treatment
-----------------
* Device: Inion OTPS Biodegradable Fixation System


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Distal fibular fracture including either instabile/dislocated Weber class B or any Weber class C fracture OR bimalloelar fracture with lateral malloelus fracture and medial malleolus fracture OR trimalleolar fracture with lateral and medial malleolus fractures and posterior malleolus fracture with less than 1/4 of the articulas surface fractured Fresh/acute fracture Aged between 18 and 60 years Exclusion Criteria: Contraindication for the Inion OTPS Biodegradable Fixation System:Active or potential infection,patient's conditions, limited blood supply, insufficient quantity or quality of bone,where patient cooperation can not be quaranteed Multiple trauma Previous ankle fracture Pregnancy Bone malignancy Any clinically significant condition based on investigators judgement high-load bearing applications

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Inion OTPS Biodegradable Fixation System|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Functional performance will be determined by using Kaikkonen Functional Scale (Kaikkonen et. al. 1994) and Olerud and Molander Ankle Score (Olerud and Molander 1984) at 12 months post-operatively. |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sequential post-operative radiographs at 12 months post-operatively; Timepoints for returning to work and/or sport; Wound healing; SF-36 Questionnaire; Subjective pain evaluation |  |  |
Reliability of the Angle Measurement of the Software for Photogrammetry Postural Assessment (SAPO)

Study Overview
=================
Brief Summary
-----------------
The present study aims to verify the reliability of intra and inter-examiner of angular measures proposed by SAPO postural assessment software. Methods: 24 subjects were photographed and three experienced examiners analyzed the images.

Detailed Description
-----------------
The body posture in the orthostatic position has been widely utilized as in the clinical practice as in the research, for the diagnosis and physiotherapy treatment planning. The photogrammetry has been used as a valuable resource for the physiotherapist's diagnosis and verification of measuring postural changes, but the lack of standardization of anatomic references, the used angles between them and their meaning embarrasses comparison among studies.

Official Title
-----------------
Reliability of the Angle Measurement of the Software for Photogrammetry Postural Assessment

Conditions
-----------------
Body Posture Alignment Condition, Temporomandibular Disorder

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 20-35 years old diagnosis of temporomandibular disorder Exclusion Criteria: neurological diseases systemic diseases lower limbs fracture balance disorder

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
reliability, photogrammetry
Somatostatin, Octreotide, Pentoxyfilline in the Prevention of Post-ERCP Pancreatitis and Molecular Markers

Study Overview
=================
Brief Summary
-----------------
Octreotide, somatostatin and pentoxyfilline commercially available drugs that are used in various clinical situations. They are safe and known for years. Octreotide and somatostatin have been used in many studies for the prophylaxis and treatment of pancreatitis and post-ERCP pancreatitis, while pentoxyfilline has shown effect on patients with alcoholic hepatitis, obstructive vasculitis etc. The aim of the study is to evaluate the efficacy of any of those treatments for the prophylaxis and treatment of post-ERCP pancreatitis. In addition some molecular markers of acute and chronic inflammation will be measured before and after the endoscopic procedures according to the study protocol.

Official Title
-----------------
Effect of Octreotide, Somatostatin, Pentoxyfilline or Placebo in the Prevention and the Course of Post-ERCP Pancreatitis and Study of Molecular Markers in Post-ERCP Pancreatitis

Conditions
-----------------
Post-ERCP Acute Pancreatitis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients undergoing endoscopic retrograde cholangiopancreatography Exclusion Criteria: children, pregnant or breastfeeding women patients with coagulation disorders inability to access the papilla of Vater due to technical difficulties (previous surgery, malignant obstruction)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
post-ERCP pancreatitis, prophylaxis, prognosis, natural course, molecular markers
Selective Laryngeal Reinnervation for Bilateral Vocal Fold Paralysis

Study Overview
=================
Brief Summary
-----------------
This is a prospective observational study examining the treatment outcomes of selective laryngeal reinnervation procedures for patients with bilateral vocal fold paralysis.

Official Title
-----------------
Selective Laryngeal Reinnervation for Bilateral Vocal Fold Paralysis

Conditions
-----------------
Bilateral Vocal Cord Paralysis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients aged 18-70 Patients with bilateral vocal fold paralysis without any improvement for 6 months Exclusion Criteria: Patients with neck or chest radiation Patients with severe respiratory compromise Patients with cricoarytenoid ankylosis Patients with pacemakers Patients who are pregnant Patients with cochlear implant, or any nerve stimulator implants

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in breathing function is being assessed and measured by the Dyspnea Index (DI) | The DI is a standardized and validated tool to quantify patients' symptoms of upper airway dyspnea. It's a 10-item questionnaire. The lowest score is 0, which indicates that the patient is never experiencing dyspnea symptoms, and the highest is 40, which indicates that the patient is always experiencing dyspnea symptoms. | Pre-surgery and then post-surgery at 1 week, 1 month, 3 months and every 3 months thereafter up to 18 months, then at 24 months | 
| Change in breathing function is being assessed and measured by pulmonary function testing | Pulmonary function testing will measure the total inspiratory and expiratory tidal volumes. | Pre-surgery and then post-surgery at 1 week, 1 month, 3 months and every 3 months thereafter up to 18 months, then at 24 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Stridor, Bilateral vocal fold paralysis, Tracheostomy dependency, Glottic airway obstruction
Preload Dependency by Impedance Cardiography After Cardiac Surgery

Study Overview
=================
Brief Summary
-----------------
The primary purpose of this study is to investigate wether the measure of stroke volume (SV) variations by impedance cardiography during passive leg raising (PLR) can reliably predict preload dependency after cardiac surgery, in comparison to a reference parameter : velocity time integral (VTI) variation measured by transthoracical echocardiography.

Official Title
-----------------
Noninvasive Assessment of Preload Dependency by Passive Leg Raising Test and Impedance Cardiography Compared to Echocardiographic Measurements After Cardiac Surgery

Conditions
-----------------
Cardiac Surgery With Extracorporeal Circulation

Intervention / Treatment
-----------------
* Device: Impedance cardiography Physioflow ®


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Men or women over 18 years Affiliated to a social protection Signed written consent Informed about the results of the medical visit All type of cardiac surgery with extracorporeal circulation performed at University Hospital of Strasbourg Sedated and under mechanical ventilation Exclusion Criteria: Cardiac arrhythmia Contraindication to PLR maneuver Exclusion period due to inclusion in a previous or ongoing study Impossibility to provide enlightened information Patient deprived of liberty, under judicial protection, trusteeship or guardianship Pregnancy, lactation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br> | Device: Impedance cardiography Physioflow ®<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Area under ROC curve comparing SV variation (impedance cardiography) and VTI variation after PLR | Patients classified as responders and non responders to PLR : VTI variation ≥ 12% or < 12% | Within the 6 first hours after cardiac surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Variation of central veinous pressure, left auricular pressure and left ventricular filling pressures after PLR (ROC curves, correlation tests) |  | Within the 6 first hours after cardiac surgery | 
| Respiratory variation of inferior vena cava |  | Within the 6 first hours after cardiac surgery |
Myomectomy During Cesarean Section Is This Aright Decision

Study Overview
=================
Brief Summary
-----------------
myomectomy was done during cesarean section

Detailed Description
-----------------
The myomectomy was done by conventional technique but timing of myomectomy either before or after delivery of the baby varied between different cases .Infusion of oxytocin during the operation and for 24 h later.

Official Title
-----------------
Myomectomy During Cesarean Section,Is This Aright Decision

Conditions
-----------------
Obstetric Labor, Premature

Intervention / Treatment
-----------------
* Procedure: myomectomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: women with diagnosed uterine myoma prior to pregnancy needed cesarean sections for various indications. Women with diagnosed uterine myoma during pregnancy and needed cesarean sections for various indications. Women with myoma diagnosed incidentally during labour. Exclusion Criteria: Refusal of the women at any time before and during the operations. Cervical myoma. Atonic uterus after delivery of the baby. Women with bleeding disorders due to medical or obstetric causes.
Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: myomectomy|The myomectomy was done by conventional technique but timing of myomectomy either before or after delivery of the baby varied between different cases .Infusion of oxytocin during the operation and for 24 h later.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| difficulty of cesarean myomectomy | according to the site and type of myoma | during the procedure/surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 4concentrations of hemoglobin | intra operative bleeding | during the procedure |
Effect of Orange Juice on Glycemic Response

Study Overview
=================
Brief Summary
-----------------
Orange juice naturally contains high concentrations of hesperidin, which affects glucose absorption in in vitro experiments. This study is to test if hesperidin and other components of orange juice (not other sugars or organic acids) affect the post-prandial blood glucose concentration derived from sugars already present in the orange juice.

Detailed Description
-----------------
Healthy volunteers will consume orange juice with added water or food-grade hesperidin.

Official Title
-----------------
Effect of Hesperidin in Orange Juice on Glycemic Response in Healthy Volunteers

Conditions
-----------------
Effect of Food on Postprandial Hyperglycemia

Intervention / Treatment
-----------------
* Other: control
* Other: test meal 1
* Other: test meal 2
* Other: test meal 3


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: fasting blood glucose below 5.9 mM Exclusion Criteria: fasting glucose above 6 mM pregnant

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: control meal<br>glucose, fructose, sucrose, malic acid and citric acid in water | Other: control<br>* balancing sugars and organic acids<br>|
| Experimental: test meal 1<br>orange juice with added hesperidin (low dose) | Other: test meal 1<br>* orange juice plus hesperidin low dose<br>|
| Experimental: test meal 2<br>orange juice with added hesperidin (high dose) | Other: test meal 2<br>* orange juice plus hesperidin higher dose<br>|
| Experimental: test meal 3<br>diluted orange juice with added hesperidin | Other: test meal 3<br>* diluted orange juice plus hesperidin low dose<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood glucose concentration | iAUC/[glucose]max | 3 hours |
Emergency Department, Rapid Assessment for Sexually Transmitted Infection

Study Overview
=================
Brief Summary
-----------------
To evaluate if a rapid urine Nucleic Acid Amplification Testing (NAAT) is non-inferior to the traditional swab NAAT for gonorrhea and chlamydia when performed in the Emergency Department.

Detailed Description
-----------------
All patients presenting to the Emergency Department during the study period who are tested for gonorrhea and chlamydia by the traditional swab NAAT will concurrently have their urine tested for gonorrhea and chlamydia using the Cepheid GeneXpert rapid NAAT. The result of both tests will be compared to determine if the rapid assay is non-inferior to the current traditional NAAT. Both the traditional and Cepheid GeneXpert rapid NAAT are FDA and CDC approved for evaluation of gonorrhea and chlamydia. However, the Cepheid GeneXpert rapid NAAT has not been prospectively validated in the Emergency Department setting. We intend for both the provider obtaining the sample and the technician running the rapid assay sample to be blinded to the result of the traditional NAAT. The Cepheid GeneXpert rapid NAAT will not be used in patient care decisions.

Conditions
-----------------
Infection

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical concern for gonorrhea and/or chlamydia infection Concurrent testing for gonorrhea and chlamydia using traditional NAAT assay Exclusion Criteria: age <18 years

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnosis of a chlamydia trachomatis or neisseria gonorrhoeae | comparative test characteristics to traditional swab in the Emergency Department. | 24 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
sexually transmitted infection, gonorrhea, chlamydia, presumptive therapy