AMH, Glucose Intolerance and Metabolic Syndrome in PCOS

Study Overview
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Brief Summary
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Association between serum anti-Mullerian hormone (AMH) level and prevalence of glucose intolerance and metabolic syndrome in women with polycystic ovary syndrome (PCOS)

Detailed Description
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To study the association between serum anti-Mullerian hormone (AMH) level and glucose intolerance and metabolic syndrome in women with polycystic ovary syndrome (PCOS). Glucose intolerance is detected by 2-hours 75 gram oral glucose tolerance test (OGTT). Metabolic syndrome is diagnosed by using the Harmonized criteria; the presence of any 3 of 5 following risk factors constitutes a diagnosis of metabolic syndrome. Elevated waist circumference (> 80 cm in Asian women) Elevated triglycerides (> 150 mg/dL) Reduced HDL-cholesterol (< 50 mg/dL) Elevated blood pressure )systolic > 130 and/or diastolic > 85 mmHg) Elevated fasting glucose ( > 100 mg/dL) Percentage of glucose intolerance and metabolic syndrome in PCOS women as well was any differences in parameters between PCOS patients with and without glucose intolerance and metabolic syndrome will be analysed.

Official Title
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Anti-Müllerian Hormone and Its Association With Glucose Intolerance and Metabolic Syndrome in Women With Polycystic Ovary Syndrome

Conditions
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Polycystic Ovary Syndrome

Intervention / Treatment
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* Other: serum


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: PCOS diagnosed by Rotterdam criteria 2003 Exclusion Criteria: Pregnancy Previous any hormonal uses in the last 3 months Previous hypoglycemic drugs or insulin-sensitising agents use in the last 3 months Previous chemotherapy, ovarian surgery, pelvic irradiation Menopause

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| polycystic ovary syndrome women<br>PCOS women diagnosed by Rotterdam criteria visiting the Gynecologic Unit at King Chulalongkorn Memorial Hospital and meet the inclusion criteria and no exclusion criteria of the study | Other: serum<br>* Serum for serum anti-Mullerian hormone, 2-hour 75 gram oral glucose tolerance test and lipid profiles<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differences between serum AMH level between PCOS women with and without glucose intolerance and metabolic syndrome | Any differences between mean of serum AMH levels in PCOS with and without glucose intolerance and metabolic syndrome | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of glucose intolerance in PCOS women | Percentage of glucose intolerance detected by 75 g OGTT in PCOS women | 6 months | 
| Percentage of metabolic syndrome in PCOS women | Percentage of metabolic syndrome defined by the Harmonized criteria in PCOS women | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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polycystic ovary syndrome, Serum anti-Mullerian hormone, glucose intolerance, metabolic syndrome