Metabolic Risk Factors and Myocardial Oxygenation Reserve

Study Overview
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Brief Summary
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The purpose of this study is to use MRI images using the OS-CMR technique to view the differences in the hearts of healthy volunteers and participants with a condition called Metabolic Syndrome. The objectives of this project are to compare these two groups and to view how health risks, blood test results, and the time since a Metabolic diagnosis can affect heart health.

Detailed Description
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Myocardial oxygenation changes during vasoactive breathing maneuvers, observed with oxygenation-sensitive cardiac MRI, will be identified and compared between individuals considered healthy and those fitting the criteria of the Metabolic Syndrome.

Official Title
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Metabolic Risk Factors and Myocardial Oxygenation Reserve (META-MORE)

Conditions
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Metabolic Syndrome

Intervention / Treatment
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* Diagnostic Test: Cardiac MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient Participants: Age 18-80 Informed Consent Diagnosis of MetS (through at least 3 MetS characteristics (abdominal obesity, high triglyceride level, low HDL cholesterol, high systolic blood pressure, and high fasting glucose levels) Healthy Volunteers: Age 18-80 No known current or pre-existing significant medical problems that would affect the cardiovascular or respiratory system No Smoking Exclusion Criteria: General MRI contraindications* Pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, knowledge or suspicion of pregnancy. Consumption of caffeine (coffee, tea, cocoa, chocolate, energy drink) during the 12 hours prior to the exam

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patient Participant<br>Participants with known Metabolic Syndrome (MetS) | Diagnostic Test: Cardiac MRI<br>* Participants will undergo an oxygenation-sensitive cardiac MRI and, during the scan, perform a vasoactive breathing maneuver composed of a period of paced hyperventilation followed by a voluntary maximal breath hold.<br>* Other names: Breathing Maneuvers;|
| Healthy Volunteers<br>NonS-moking participants with no known pre-existing conditions and who do not take any medications | Diagnostic Test: Cardiac MRI<br>* Participants will undergo an oxygenation-sensitive cardiac MRI and, during the scan, perform a vasoactive breathing maneuver composed of a period of paced hyperventilation followed by a voluntary maximal breath hold.<br>* Other names: Breathing Maneuvers;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Global and segmental Myocardial oxygenation reserve (MORE) | A t-test will be used to assess the difference in global and segmental MORE, at rest, during hyperventilation, and throughout breath hold, between healthy and volunteers and MetS patients. | Baseline | 
| Relation between Breathing maneuver induced MORE and known MetS risk factors. | A linear regression will assess the relation between Breathing maneuver induced MORE and known MetS risk factors, biomarkers, and time since diagnosis. | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Myocardial oxygenation