A Danish Audit of Small Bowel Obstruction

Study Overview
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Brief Summary
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Small bowel obstruction (SBO) is a common and potentially life-threatening acute surgical condition. A minority of patients present with a clear indication for urgent surgical intervention, either on the basis of clinical or radiological assessment (clinical signs of peritonitis/sepsis; suspicion of bowel ischaemia; closed loop obstructions; irreducible herniae etc.). However, the optimal management of the remaining patients, the majority of whom present with SBO caused by abdominal adhesions, remains a topic of international debate with practice varying in different healthcare systems. This multicentre, prospective, observational study aims to describe the current management of patients admitted with SBO in 6 acute hospitals (Bispebjerg, Herlev, Hillerød, Hvidovre, Køge, Slagelse) on the island of Sjælland, Denmark, which accounts for a 1/3 of the total Danish population.

Detailed Description
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This is a prospective, non-interventional observational study of the management and outcomes of patients admitted with SBO in Denmark. Relevant clinicopathological demographics will be retrieved from consenting patients' medical records. An initial analysis will be performed once these patients have reached 90 days follow-up after the start of treatment. The long-term outcomes of treatment will be assessed with further analyses at 1, 3 and 5 years follow-up.

Official Title
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A Danish Audit of Small Bowel Obstruction

Conditions
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Bowel Obstruction Small

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥ 18 years old Radiological or clinical diagnosis of mechanical SBO Admitted to one of the 6 participating centres Exclusion Criteria: SBO presenting within 30 days of a previous abdominal operation

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Small Bowel obstruction<br>Patients admitted with a diagnosis of small bowel obstruction at 1 of the 6 participating centres | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 30-day morbidity rate |  | 30 days | 
| 30-day mortality rate |  | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 90-day mortality rate |  | 90 days | 
| To describe the proportion of patients undergoing operative versus non-operative management |  | From 90 days | 
| To determine the success rate of non-operative management in patients with SBO and identify predictors of success/failure |  | From the start of treatment until 90-days follow-up | 
| To determine the incidence and consequence of acute kidney injury in patients with SBO |  | 90 days | 
| To determine the incidence and consequence of malnourishment in patients with SBO |  | 90 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Small Bowel Obstruction