Relationship of Cerebral Perfusion Pressure Variability to Sepsis-associated Encephalopathy

Study Overview
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Brief Summary
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The purpose of the study is to evaluate whether variability of CPP (cerebral perfusion pressure) is related to sepsis-associated encephalopathy and outcomes of patients with sepsis.

Detailed Description
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Encephalopathy is a common complication of sepsis, impaired cerebrovascular autoregulation (AR) in patients with sepsis is considered related to Sepsis-associated encephalopathy (SAE). As AR is important in stabilizing the cerebral perfusion pressure, whether greater variability of CPP is related to SAE and mortality or not remains unclear. We conduct this study to evaluate the relationship between them.

Official Title
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Relationship of Cerebral Perfusion Pressure Variability to Sepsis-associated Encephalopathy

Conditions
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Sepsis

Intervention / Treatment
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* Other: no interventions


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: clinical symptoms of sepsis, severe sepsis and septic shock age over 18 years Exclusion Criteria: preexisting Neurological diseases traumatic brain injury intracranial infectious disease severe hepatic or renal dysfunction ICU discharge Within 72 hours pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| SAE<br>patient who develop encephalopathy in the progress of sepsis | Other: no interventions<br> <br> |
| non-SAE<br>patient who do not develop encephalopathy in the progress of sepsis | Other: no interventions<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| relationship between cerebral perfusion pressure variability and sepsis-associated encephalopathy | To estimate CPP noninvasively, we will monitor the middle cerebral artery flow velocity of patients with sepsis using transcranial Doppler ultrasound in the first 72h of their enrollment. Diagnosis of a SAE was performed using the confusion assessment method for ICU(CAM-ICU). | cerebral perfusion pressure is assessed up to 72 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of mechanical ventilation |  | All the participants will be followed up until discharge or death, assessed up to 24 months | 
| Time of ICU stay |  | All the participants will be followed up until discharge or death, assessed up to 24 months | 
| Time of hospital stay |  | All the participants will be followed up until discharge or death, assessed up to 24 months | 
| 90-day mortality rate |  | All the participants will be followed up until 90 days after their enrollment or death | 
| 1-year mortality rate |  | All the participants will be followed up until 1 year after their enrollment or death | 
| 2-year mortality rate |  | All the participants will be followed up until 2 years after their enrollment or death | 
| 1-year quality of life of survivors | EQ-5D will be used to evaluate quality of life of survivors | All the participants will be followed up until 1 year after their enrollment or death | 
| 2-year quality of life of survivors | EQ-5D will be used to evaluate quality of life of survivors | All the participants will be followed up until 2 year after their enrollment or death | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cerebral perfusion pressure, septic encephalopathy