Protocol for Evaluation of Quarter-Time Cardiac Imaging: 5-Minutes Rest and 3-Minutes Stress Wide Beam Reconstruction (WBR) Versus Full-Time Filtered Back Projection (FBP)

Study Overview
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Brief Summary
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A new, innovative software image processing method, wide beam reconstruction (WBR), utilizes resolution recovery and incorporates Poisson noise-reduction into the reconstruction process of NM images. This method facilitates the reconstruction of low count density myocardial perfusion SPECT images. Preliminary research indicates that SPECT acquisition time consequently can be reduced by 60% (less than 5 minutes) for rest and by 75% (just over 3 minutes) for stress, while tomographic image quality is maintained, or even improved. Such a decrease in image acquisition time decreases patient discomfort during the tomographic acquisition, decreases the opportunity for patient motion, and improves laboratory efficiency.

Detailed Description
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Standard full-time SPECT will be processed using FBP and compared to 3-minute stress and 5-minute rest scans processed with WBR. The following scan parameters will be evaluated: image quality; perfusion defect extent, severity, and reversibility; transient ischemic dilatation; left ventricular end-diastolic volume; left ventricular end-systolic volume; left ventricular ejection fraction; and regional wall motion and wall thickening abnormalities. These parameters will be assessed visually by experienced Nuclear physicians (at least 2 blinded readers) and quantitatively using several different commercially available software programs.

Official Title
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Quarter-Time Myocardial Perfusion SPECT

Conditions
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Cardiac Diseases

Intervention / Treatment
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* Device: quarter-time stress scans reconstructed by WBR (4SPS) - Xpress3.Cardiac
* Device: quarter-time rest scans reconstructed by WBR (6/8/10 SPS) - Xpress3.Cardiac


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient is clinically stable Patient is able to tolerate additional 8 minutes of scanning Patient is willing to undergo additional 8 minutes of scanning Exclusion Criteria: Unstable patient Non-consenting patient

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| FBP studies<br>standard filtered backprojection image processing/reconstruction of full-time acquisition data | Device: quarter-time stress scans reconstructed by WBR (4SPS) - Xpress3.Cardiac<br>* Comparison of the diagnostic quality of quarter-time WBR stress with stress studies generated via FBP and half-time WBR<br>* Other names: Xpress3.Cardiac;Device: quarter-time rest scans reconstructed by WBR (6/8/10 SPS) - Xpress3.Cardiac<br>* Comparison of the diagnostic quality of 6 SPS quarter-time rest acquisitions with FBP and half-time WBR rest studies; simulated 8 SPS and 10 SPS quarter-time rest acquisitions are also compared to FBP and half-time WBR rest studies.<br>* Other names: Xpress3.Cardiac;|
| half-time WBR<br>wide-beam reconstruction of simulated half-time acquisitions from standard full-time acquisitions | Device: quarter-time stress scans reconstructed by WBR (4SPS) - Xpress3.Cardiac<br>* Comparison of the diagnostic quality of quarter-time WBR stress with stress studies generated via FBP and half-time WBR<br>* Other names: Xpress3.Cardiac;Device: quarter-time rest scans reconstructed by WBR (6/8/10 SPS) - Xpress3.Cardiac<br>* Comparison of the diagnostic quality of 6 SPS quarter-time rest acquisitions with FBP and half-time WBR rest studies; simulated 8 SPS and 10 SPS quarter-time rest acquisitions are also compared to FBP and half-time WBR rest studies.<br>* Other names: Xpress3.Cardiac;|
| Quarter-time stress<br>4 seconds per stop post-stress SPECT acquisitions reconstructed by the wide-beam reconstruction method | Device: quarter-time stress scans reconstructed by WBR (4SPS) - Xpress3.Cardiac<br>* Comparison of the diagnostic quality of quarter-time WBR stress with stress studies generated via FBP and half-time WBR<br>* Other names: Xpress3.Cardiac;|
| Quarter-time rest<br>6 seconds per stop rest SPECT acquisitions reconstructed by the wide-beam reconstruction method | Device: quarter-time rest scans reconstructed by WBR (6/8/10 SPS) - Xpress3.Cardiac<br>* Comparison of the diagnostic quality of 6 SPS quarter-time rest acquisitions with FBP and half-time WBR rest studies; simulated 8 SPS and 10 SPS quarter-time rest acquisitions are also compared to FBP and half-time WBR rest studies.<br>* Other names: Xpress3.Cardiac;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Image quality of quarter-time WBR images is equivalent/superior to full-time FBP |  | March 2008 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Image quality of quarter-time WBR is equivalent/superior to half-time WBR |  | March 2008 |