Sonographic Measurement of Bladder Wall Thickness in Patients With Neurogenic Bladder Dysfunction

Study Overview
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Brief Summary
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Video-urodynamic investigations are regarded as the current standard diagnostics for neurogenic bladder dysfunction in patients with spinal cord injury. This examination is exact, but time consuming, costly and associated with the risk of urinary tract infection. In patients with lower urinary tract symptoms due to benign prostate hyperplasia, sonographic measurement of bladder wall thickness has been demonstrated to be able to replace urodynamic testing for the diagnosis of infravesical obstruction. Hypothesis: measurement of bladder wall thickness in patients with neurogenic bladder dysfunction due to spinal cord injury is closely related to the known risk factors for upper urinary tract deterioration (bladder compliance, detrusor leak point pressure) in this group of patients and can therefore replace urodynamic examination in selected cases.

Official Title
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Sonographic Measurement of Bladder Wall Thickness in Patients With Neurogenic Bladder Dysfunction Due to Spinal Cord Injury

Conditions
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Spinal Cord Injury

Intervention / Treatment
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* Other: sonographic measurement of bladder wall thickness


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: neurogenic bladder dysfunction due to spinal cord injury ability to understand German language willingness and capability to undergo urodynamic testing age > or = 18 years Exclusion Criteria: acute urinary infection at the time of examination known bladder tumor or bladder stone age < 18 years not capable to understand aim and purpose of the examination

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| one arm; neurogenic bladder dysfunction<br>evaluation of the clinical utility of bladder wall thickness as a diagnostic tool in patients with spinal cord injury | Other: sonographic measurement of bladder wall thickness<br>* measurement of bladder wall thickness by ultrasound at different filling states of the bladder during urodynamic investigation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| correlation bladder wall thickness and detrusor compliance | measurement of detrusor compliance at maximum bladder volume; measurement of bladder wall thickness at maximum bladder volume | calculated from maximum bladder filling | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| correlation bladder wall thickness and maximum detrusor pressure | correlation between bladder wall thickness and maximum detrusor pressure during the urodynamic storage phase | measurement at maximum bladder capacity | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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spinal cord injury, urodynamics, ultrasound, neurogenic bladder dysfunction