Cold Snare Polypectomy Vs. Cold Forceps Polypectomy Using Narrow-band Imaging Endoscopy for Removal of Diminutive Colorectal Polyps

Study Overview
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Brief Summary
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The purpose of this study is to compare cold snare polypectomy and cold forceps polypectomy using narrow-band imaging endoscopy for removal of diminutive colorectal polyps.

Detailed Description
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Previous study found Cold snare polypectomy a preferable technique in comparison to cold biopsy for diminutive polyps when assessed for completeness of resection. However, it is expected that cold biopsy polypectomy with advanced endoscopy, such as chromoendoscopy or narrow-band imaging endoscopy, increase completeness of resection. One study showed 90% of the diminutive polyps were completely resected using cold biopsy polypectomy with chromoendoscopy. However, no study compared cold snare polypectomy and cold biopsy polypectomy using Narrow-band Imaging endoscopy for Removal of Diminutive Colorectal Polyps. The aim of this study is to compare cold snare polypectomy and Cold biopsy Polypectomy Using Narrow-band Imaging Endoscopy for Removal of Diminutive Colorectal Polyps

Official Title
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Prospective Comparison of Cold Snare Polypectomy and Cold Forceps Polypectomy Using Narrow-band Imaging Endoscopy for Diminutive Colorectal Polyps

Conditions
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Polyp of Large Intestine

Intervention / Treatment
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* Procedure: Cold biopsy polypectomy
* Procedure: Cold snare polypectomy
* Device: Cold snare polypectomy
* Device: Cold biopsy polypectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients over the age of 20 years undergoing routine colonoscopy (screening, surveillance, or diagnostic) Exclusion Criteria: patients taking antiplatelet or anticoagulant therapy during the past 1 week of the procedure known coagulopathy history of inflammatory bowel diseases American Society of Anesthesiology class III or more pregnancy.

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: cold biopsy polypectomy<br> | Procedure: Cold biopsy polypectomy<br>* removal of eligible polyps using cold biopsy technique until no polyp was visible by narrow-band imaging endoscopy<br>Device: Cold biopsy polypectomy<br>* standard- capacity forceps with narrow band imaging endoscopy<br>|
| Experimental: Cold snare polypectomy<br> | Procedure: Cold snare polypectomy<br>* removal of eligible polyps using cold snare polypectomy technique<br>Device: Cold snare polypectomy<br>* mini (10 mm open diameter) size electrosurgical snare without application of electrocautery<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| complete histologic polyp eradication rate |  | 2 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rates of tissue retrieval per polyp |  | 2 weeks |