Taste Acuity and Caloric Intake After Acute Morphine Administration

Study Overview
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Brief Summary
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This study will investigate the effects of acute morphine administration on taste acuity and how much a person eats. It is hypothesized that there will be a dose dependent decrease in taste acuity and dose dependent increase in food intake associated with acute morphine administration. Knowledge from this study will impact the future of feeding behavior and obesity research in the general population. Results will also promote exploration of the long-term effect of opioid abuse on taste acuity and feeding behavior in substance abusing populations.

Official Title
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Taste Acuity and Caloric Intake After Acute Morphine Administration

Conditions
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Taste Sweet, Taste Salty, Feeding Behavior

Intervention / Treatment
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* Behavioral: taste acuity assessment
* Behavioral: Recorded meal


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy adult male and female volunteers Ages of 18 to 65 Exclusion Criteria: History of drug dependence (including opioid use disorders) History of taste dysfunction Significant medical or Axis I psychiatric disorder Any trauma or surgical procedures to the head or neck region Medication or illicit drug more than 4 out of the last 30 days. Pregnancy Abnormal electrocardiogram findings Negative rating of greater than 40% of the foods available for consumption

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Morhpine/Taste acuity<br>Taste acuity assessment after 1mg subcutaneous morphine injection | Behavioral: taste acuity assessment<br>* Quantitative measurement of for tasting detection and recognition thresholds, magnitude of perception and hedonic response.<br>Behavioral: Recorded meal<br> <br> |
| Placebo Comparator: Placebo/Taste acuity<br>Taste acuity assessment after subcutaneous placebo injection | Behavioral: taste acuity assessment<br>* Quantitative measurement of for tasting detection and recognition thresholds, magnitude of perception and hedonic response.<br>Behavioral: Recorded meal<br> <br> |
| Active Comparator: Morphine4/Taste acuity<br>Taste acuity assessment after 4mg subcutaneous morphine injection | Behavioral: taste acuity assessment<br>* Quantitative measurement of for tasting detection and recognition thresholds, magnitude of perception and hedonic response.<br>Behavioral: Recorded meal<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Taste | The primary outcome variable will be the taste acuity profile, which includes the taste detection threshold, recognition threshold, magnitude estimation, and hedonic response. | 3 hours after dose administration | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Calories | The secondary outcome measure will be the amount of calories consumed over a 2 hours period following the drug administration. | 6 hours after dose administration | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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opioid, Taste acuity, Feeding behavior, Quantitative assessment