Dexmedetomine vs Dexamethasone in TAB Block for Abdominal Surgries

Study Overview
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Brief Summary
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Randomized controlled clinical Trial to compare the efficacy and duration of postoperative analgesia achieved after adding dexmedetomidine or dexamethasone to bupivacaine in TAP block for lower open abdominal surgeries.

Detailed Description
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A Comparative study between the use of dexmedetomidine versus dexamethasone as adjuvant to bupivacaine in ultrasound-guided transversus abdominis plane block for post-operative pain relief in patients undergoing lower open abdominal surgeries

Official Title
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A Comparative Study Between the Use of Dexmedetomidine Versus Dexamethasone as Adjuvant to Bupivacaine in Ultrasound-guided Transversus Abdominis Plane Block for Post-operative Pain Relief in Patients Undergoing Lower Open Abdominal Surgeries

Conditions
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Anesthesia

Intervention / Treatment
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* Drug: Dexmedetomidine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patients, Age 20-60 years. Elective operation under general anesthesia. Physical Status: ASA I and II Patients. Body mass index 25-35 kg/m2. Exclusion Criteria: Infection at site of injection. Patient refusal. Psychiatric or physical illness that lead to inability to cooperate, speak or read. Abdominal operations under spinal anesthesia. History or evidence of coagulopathy. Known allergies to drugs used . Preexisting neurological disorders.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group A (n=15): (Dexamethasone group)<br>Patients will receive 20 ml 0.25% bupivacaine plus 4 mg dexamethasone on each side TAB bock. | Drug: Dexmedetomidine<br>* adjuvants to 0.25 bupivacaine in TAB block.<br>* Other names: dexamethasone;|
| Active Comparator: Group B (n=15): (Dexmedetomidine group)<br>Patients will receive 20 ml 0.25% bupivacaine plus 0.5 mcg/kg of dexmedetomidine on each side TAB block. | Drug: Dexmedetomidine<br>* adjuvants to 0.25 bupivacaine in TAB block.<br>* Other names: dexamethasone;|
| Sham Comparator: Group C (n=15): (control group)<br>Patients will receive 20 ml 0.25% bupivacaine on each side TAB block. | Drug: Dexmedetomidine<br>* adjuvants to 0.25 bupivacaine in TAB block.<br>* Other names: dexamethasone;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 1st time for rescue analgesia | Time to first analgesia requirment(starting from drug injection) | first 24 hours post-operatively | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain score- Visual Analogue Score (VAS) | It ranges from 0 indicating no pain till 10 indicating severe intolerable pain with variable degrees of ascending pain in between] was assessed at 0 min (AT PACU), 2hr,6 hr, 12 hr, 18 hr, and 24 hr postoperatively. | First 24 hours post-operatively. |