Effects of Oxytocin on Hemodynamics in Patients Undergoing Laparoscopic Myomectomy

Study Overview
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Brief Summary
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This project will study the effect of oxytocin on hemodynamics in patients undergoing laparoscopic myomectomy, and how to prevent and manage such hemodynamic changes effectively.It provides a reference for the rational use of oxytocin in clinical practice, which can not only effectively contract the uterus and reduce bleeding, but also reduce the influence on hemodynamics.

Official Title
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Effects of Oxytocin on Hemodynamics in Patients Undergoing Laparoscopic Myomectomy

Conditions
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Oxytocin, Hemodynamic Monitoring, Laparoscopic Surgery

Intervention / Treatment
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* Drug: Oxytocin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: General anesthesia for gynecological laparoscopic surgery,ASA I III Exclusion Criteria: Oxytocin use contraindications

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: group 1 with no oxytocin<br> | |
| Experimental: group 2 with oxytocin 10 U IM + oxytocin 10 U IV<br> | Drug: Oxytocin<br>* During the laparoscopic hysteromyomectomia operation, different doses of oxytocin was used with different routs.<br>|
| Experimental: group 3 with oxytocin 20 U IM + oxytocin 0 U IV<br> | Drug: Oxytocin<br>* During the laparoscopic hysteromyomectomia operation, different doses of oxytocin was used with different routs.<br>|
| Experimental: group 4 with oxytocin 0 U IM + oxytocin 20 U IV<br> | Drug: Oxytocin<br>* During the laparoscopic hysteromyomectomia operation, different doses of oxytocin was used with different routs.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of traditional hemodynamic parameters after oxytocin use during laparoscopic hysteromyomectomia. | Parameters including SBP, DBP, MAP (mmHg) were measured by a Mostcare hemodynamic monitor. | before induction, before incision, before oxytocin intramuscular injection, and 20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection. | 
| Changes of traditional hemodynamic parameters after oxytocin use during laparoscopic hysteromyomectomia. | HR (beats/min) was measured by a Mostcare hemodynamic monitor. | before induction, before incision, before oxytocin intramuscular injection, and 20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection. | 
| Changes of volume management parameters after oxytocin use during laparoscopic hysteromyomectomia. | SVV (%) was measured by a Mostcare hemodynamic monitor. | before induction, before incision, before oxytocin intramuscular injection, and 20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection. | 
| Changes of volume management parameters after oxytocin use during laparoscopic hysteromyomectomia. | SVRI (dynes-sec/cm-5) was measured by a Mostcare hemodynamic monitor. | before induction, before incision, before oxytocin intramuscular injection, and 20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection. | 
| Changes of volume management parameters after oxytocin use during laparoscopic hysteromyomectomia. | CI (l/min/m2) was measured by a Mostcare hemodynamic monitor. | before induction, before incision, before oxytocin intramuscular injection, and 20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection. | 
| Changes of volume management parameters after oxytocin use during laparoscopic hysteromyomectomia. | CO (l/min) was measured by a Mostcare hemodynamic monitor. | before induction, before incision, before oxytocin intramuscular injection, and 20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Oxytocin, Hemodynamic, Myomectomy