Effect of a Physical Activity Program on the Hormonal Regulation of Food Intake

Study Overview
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Brief Summary
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The primary purpose of this protocol is to assess the hormonal regulation of satiety by an intense exercise before and after a 3 month physical activity program. Hormones assessed are: leptin, grhélin, Cholecystokinin, Glucagon-Like-Peptid-1 (GLP-1), PYY. It is well known that in overweight adults and children also, an intense physical exercise diminish the food intake relatively to the total energy expenditure and this effect is persistent after a 6 weeks physical activity program. Our hypothesis are: a diminution of food intake after the intense physical exercise and a persistent diminution of food intake after the 3 month physical activity program, an augmentation of levels of GLP-1 and PYY during the intense exercise before and after the physical activity program, a diminution of the level of GLP-1 and leptin before and after the physical activity program

Detailed Description
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There is two sequences, one before and one after the physical activity program. Each sequence contains one rest session and one exercise session. Each session contains : blood sample at regular interval (Leptin, Ghrélin, CCK, PYY, GLP-1), a sleeping assessment (Pittsburg scale), an assessment of hunger sensations at regular interval, an assessment of food intake in a ad libitum lunch and in the diner indirectly by the SU.VI.MAX. tool. During the  rest  session : Blood samples, assessment of hunger sensation, assessment of food intake are realized during the morning. Physical condition (VO2 max, DEXA, and muscular test), insulin-sensibility, lipid profile, are also assessed. During the exercise session: it is identical to the first session but an intense exercise of 40 minutes is realized at 70% of the patient's VO2 max. The peripherical blood output is measured by a non-invasive method: the Near-Infra-Red-Spectroscopy, during the exercise. The 3-months-physical activity program : there is 4 sessions of 30 minutes and 2 sessions of 1 hour per week. Most of exercises sessions are realized at home but one 1-hour session per week is controled with a sports educator.

Official Title
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Effect of a 3 Months Physical Activity Program on the Hormonal Regulation of Food Intake by Intense Physical Activity in Overweight Adolescents

Conditions
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Obesity

Intervention / Treatment
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* Behavioral: Physical activity


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Overweight adolescents (over the 90 th percentile of the international cut-off point) With a computer and an internet connection Sedentary (according to the IPAQ-A questionnaire) Without eating disorders (according to the DEBQ questionnaire) Exclusion Criteria: Medical or surgical antecedents that are incompatible with the study: cardiovascular, endocrine or digestive disease. Drugs that could interfere with the results of the study Surgical intervention in the 3 months Regular consumption of tobacco or Alcohol patients on a diet with caloric restriction Refusal to sign the consent form Regular practice of sport and intensive

Ages Eligible for Study
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Minimum Age: 12 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: obesity<br> | Behavioral: Physical activity<br>* There is two sequences, one before and one after the physical activity program. Each sequence contains one rest session and one exercise session<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison before and after the physical activity program of the effect of intense exercise on kinetic of secretion of regulation hormones: Leptin, Grhélin, CCK, PYY3-36, GLP-1 |  | after 3 months of physical activity | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison, before and after the physical activity program, of Hunger sensation by Visual Analogic Scales |  | after 3 months of physical activity | 
| Comparison, before and after the physical activity program of food intake |  | after 3 months of physical activity | 
| Comparison, before and after the physical activity program of insulinosensibility |  | after 3 months of physical activity | 
| Comparison, before and after the physical activity program of peripheral blood output |  | after 3 months of physical activity | 
| Comparison, before and after the physical activity program of sleep quality |  | agter 3 months of physical activity | 
| Comparison, before and after the physical activity program of physical condition |  | after 3 months of physical activity | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Obesity, Appetite regulation, Hormones, Adolescents, Exercise