Magnetic Resonance Imaging in the Diagnosis of Pulmonary Hypertension

Study Overview
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Brief Summary
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The aim of the present study is to identify changes in the cardiovascular system in patients with pulmonary hypertension (PH) by magnetic resonance imaging (MRI). MRI is accepted as golden standard method for the evaluation of left and right ventricular morphology and function. All patients who showed elevated pulmonary pressure in the right heart catheter investigation are assigned to MRI. Parameters derived from MRI are included in the clinical and therapeutic decisions. Well established as well as new MRI parameters are evaluated and compared to the results of right heart catheter. Further age-matched controls without known cardiac or pulmonary disease are investigated by native MRI.

Detailed Description
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Patients with suspected, latent and manifest PH and controls are investigated by MRI according to the following protocol in breathhold or free breathing (depending on the patients' breath-hold abilities). In case of elevated Creatinin values, no contrast agent is applied. Planning of cardiac views: Planning of 2-chamber view, short axes view and 4-chamber view. Morphological overview: Transversal and coronal Haste images Left and right heart functional and valve evaluation: Cine 2-chamber imaging, Multi-slice cine 4-chamber imaging, Cine Left and Right ventricular outflow tract imaging and Multi-slice cine short axes imaging covering the left and right ventricle for evaluation of EDV, ESV, SV, EF, CO and muscle mass. Phase Contrast Imaging: Flow measurements in the aorta, the pulmonary artery and the heart. Perfusion measurement. Late enhancement measurement: Multi-slice short axes view, multi-slice 2-chamber view and multi-slice 4-chamber view.

Official Title
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Magnetic Resonance Imaging in the Diagnosis of Pulmonary Hypertension

Conditions
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Pulmonary Hypertension, Ventricular Function, MR Phase Contrast Velocity Imaging, Late Enhancement Patterns

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Controls without history of cardiac or pulmonary diseases Patients with suspected PH Patients with latent PH Patients with manifest PH Exclusion Criteria: MRI exclusion criteria

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| PulmoHypertension<br>Patients with suspected, latent or manifest pulmonary hypertension | |
| Controls<br>Controls without history of cardiac or pulmonary diseases | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| right ventricular function | right ventricular end-diastolic volume (EDV), right ventricular end-systolic volume (ESV), right ventricular stroke volume (SV), right ventricular ejection fraction (EF), right ventricular cardiac output (CO), right ventricular muscle mass (RVMM) | at the MRI investigation |