Ketone Production With Acute Caffeine Intake

Study Overview
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Brief Summary
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Evaluate the effect of a caffeine supplement on the stimulation of lipolysis and the production of ketones in healthy adults (N=10).

Detailed Description
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The aim of the study is to evaluate the effect of a caffeine supplement on the stimulation of lipolysis and the production of ketones in healthy adults (N=10). Two different doses of caffeine (2.5 mg/kg of BW and 5 mg/kg of BW) are compared. All the participants have to follow three sequential visits of four hours each, which included a breakfast with one of the doses (2.5 or 5 mg/kg) of the caffeine supplement or without any supplement (baseline) and repeated blood sampling in order to evaluate ketone concentrations.

Official Title
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Stimulate the Ketogenesis by Using a Caffeine Supplement

Conditions
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Healthy Adults

Intervention / Treatment
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* Dietary Supplement: Control
* Dietary Supplement: Caffeine low dose
* Dietary Supplement: Caffeine high dose


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy adults 18 years old and over Exclusion Criteria: Drinking more than 300 mg of caffeine per day Diabetes or prediabetes Abnormal liver and kidney function Uncontrolled dyslipidemia, blood pressure Use of drugs known to influence the metabolism of lipids and carbohydrates (steroid, beta-blockers, diuretics, insulin sensitizer, etc.) Severe inflammation or infection Pregnancy Smoking

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Ketonemia following caffeine intake<br>Participants have to follow three sequential visits of four hours each, which included a breakfast with one of the doses (2.5 or 5 mg/kg) of the caffeine supplement or without any supplement (baseline) and repeated blood sampling in order to evaluate ketone concentrations. Intervention 1: Control; no caffeine intake Intervention 2: Caffeine low dose (2.5 mg/kg of BW) Intervention 3: Caffeine high dose (5.0 mg/kg of MW) | Dietary Supplement: Control<br>* 4-hour visit with no caffeine is given during a standardize breakfast follow by repeated blood sampling.<br>* Other names: CTL;Dietary Supplement: Caffeine low dose<br>* 4-hour visit with a dose of 2.5 mg/kg of caffeine is given during a standardize breakfast follow by repeated blood sampling.<br>Dietary Supplement: Caffeine high dose<br>* 4-hour visit with a dose of 5 mg/kg of caffeine is given during a standardize breakfast follow by repeated blood sampling.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Plasma Acetoacetate Concentrations | Plasma acetoacetate (µmol/L) measured over a 4 hour period. | 4 hours | 
| Plasma Beta-hydroxybutyrate Concentrations | Plasma beta-hydroxybutyrate (µmol/L) measured over a 4 hour period. | 4 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Plasma Glucose Concentrations | Plasma glucose (mmol/L) measured over a 4 hour period. | 4 hours | 
| Plasma Cholesterol Concentrations | Plasma cholesterol (mmol/L) measured over a 4 hour period. | 4 hours | 
| Plasma Triglyceride Concentrations | Plasma triglycerides (mmol/L) measured over a 4 hour period. | 4 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ketones, Glucose, Caffeine