Impact of Physical Activity on Patients With Chronic Kidney Disease Not Receiving Dialysis Followed in the TIRCEL Network. An Exposed / Unexposed Study (PHYSALYS)

Study Overview
=================
Brief Summary
-----------------
PHYSALYS is an observational multicenter study. It's an analytical study comparing 2 groups: patients exposed to physical activity and unexposed. The main objective of the study is to compare the evolution of glomerular filtration rate at inclusion and 12 months later between patients practicing physical activity and patients not practicing. If necessary, the renal disease-related complications, which are not influenced by physical activity: (type of kidney disease, age and tobacco), would be taken into account. TIRCEL patients with chronic kidney disease (CKD) at stages 3, 4 or 5 can be included in the study. Their serum creatinine data, 12 months prior to inclusion, is collected retrospectively. Patients are followed in the trial during 12 months. To evaluate physical activity, patients respond to Global Physical Activity Questionnaire 2 (GPAQ2) at inclusion and 12 months later. During this 12 months period, the same biological data are collected prospectively.

Official Title
-----------------
Impact of Physical Activity on Patients With Chronic Kidney Disease Not Receiving Dialysis Followed in the TIRCEL Network. An Exposed / Unexposed Study (PHYSALYS)

Conditions
-----------------
Renal Insufficiency, Chronic

Intervention / Treatment
-----------------
* Other: Global Physical Activity Questionnaire


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Members of TIRCEL (Traitement de l'Insuffisance Chronique en rhônE-aLpes) network for over a year and having at least two measurements of glomerular filtration rate with an interval of 9 to 12 months between the first and the last measurement Patients in stages 3, 4 or 5 of CKD No dialysis CKD patients Non transplanted CKD patients Patients seeing nephrologist Patients agreeing to be contacted for a phone call half an hour Adults patients (> 18 years) Patients not living in institution Patients being able to answer a questionnaire Exclusion Criteria: Patients followed in the TIRCEL (Traitement de l'Insuffisance Chronique en rhônE-aLpes) network for less than one year or having less than 2 measurements of glomerular filtration rate with an interval of least 9 months or over 12 months between the first and the last measurement Patients in stages 1 or 2 of CKD CKD patients receiving dialysis Transplanted CKD patients Patients not seeing nephrologist Patients refusing to be contacted for a phone call half an hour Patients < 18 years Patients living in institution Patients unable to answer a questionnaire

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| exposed = patient practicing physical activity<br>The practice of physical activity is measured by the GPAQ 2 questionnaire (Global Physical Activity Questionnaire) A patient is defined as practicing physical activity (exposed) when he meets one of the conditions following: At least 20 minutes of vigorous-intensity physical activity for at least 3 days per week At least 30 minutes of moderate-intensity physical activity or walking daily for at least 5 days per week At least 5 days of walking and moderate- or vigorous-intensity physical activity achieving at least 600 MET-minutes per week. The Metabolic equivalents (MET) is the ratio of metabolic rate during activity physical and metabolic rate at rest. One MET corresponds to the energy spent by a person sitting still and is equivalent to a consumption of 1 kcal / kg / hour. It is estimated that a moderately active person has an energetic cost four times higher, and a very active person eight times higher than the energy cost of a person sitting without move. | Other: Global Physical Activity Questionnaire<br>* The practice of physical activity is measured by the GPAQ 2 questionnaire (Global Physical Activity Questionnaire) developed by the World Health Organization.<br>|
| unexposed = patient not practicing physical activity<br>The practice of physical activity is measured by the GPAQ 2 questionnaire(Global Physical Activity Questionnaire) A patient is defined as unexposed if he does not fulfill any of these conditions : At least 20 minutes of vigorous-intensity physical activity for at least 3 days per week At least 30 minutes of moderate-intensity physical activity or walking daily for at least 5 days per week At least 5 days of walking and moderate- or vigorous-intensity physical activity achieving at least 600 MET-minutes per week. The Metabolic equivalents (MET) is the ratio of metabolic rate during activity physical and metabolic rate at rest. One MET corresponds to the energy spent by a person sitting still and is equivalent to a consumption of 1 kcal / kg / hour. It is estimated that a moderately active person has an energetic cost four times higher, and a very active person eight times higher than the energy cost of a person sitting without move. | Other: Global Physical Activity Questionnaire<br>* The practice of physical activity is measured by the GPAQ 2 questionnaire (Global Physical Activity Questionnaire) developed by the World Health Organization.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of the Glomerular Filtration Rate (GFR) | The Glomerular Filtration Rate (GFR) annual slope between inclusion (M0) and 12 months (M12) after inclusion in exposed and unexposed groups. | Month 0, Month 12 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
physical activity, chronic kidney disease, nephrology, stage 3, stage 4, stage 5