Aspirin Withdrawal in Non-ischaemic Cardiomyopathy Study

Study Overview
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Brief Summary
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Heart failure (cardiomyopathy) is a chronic condition in which the heart fails to function as a pump to move blood around the body. Aspirin has been traditionally used in heart failure because a tendency towards blood clots (including stroke and heart attack, clots in the legs and in the lungs) has been observed in this group and aspirin's mechanism of action is to prevent blood clots. This is important because two-thirds of cases of heart failure are caused by a blood clot in the coronary artery resulting in a heart attack, and aspirin is given to reduce the chances of further heart attacks. However aspirin was introduced before clinical trials as the investigators know them now were run. Systematic review of the trials of aspirin in heart failure has shown that its use does not increase survival, and there is no evidence to recommend its routine use. Another important finding was that use of aspirin may reduce the beneficial effects of ACE inhibitors which do have a mortality benefit, and that aspirin was associated with an increase in hospitalisation for heart failure compared to other drugs which prevent clots or placebo. The investigators propose that the use of aspirin in heart failure that is not caused by heart attacks (non-ischaemic cardiomyopathy) is unnecessary and could be stopped. The importance of finding evidence to cease unproven medications in heart failure cannot be understated. Patients with heart failure take an average of six prescription medications each day. Each medication has side effects and the interactions of all the drugs together are unknown. Aspirin itself is a drug which frequently has side effects of increased risk of bleeding, gastrointestinal ulceration, as well as kidney impairment. In this study, the investigators plan to withdraw aspirin from patients with stable non-ischaemic heart failure in a closely monitored environment and watch for the effect of this on heart failure.

Official Title
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Polypharmacy in the Heart Failure Patient: Are All Prescribed Drug Classes Required? Aspirin Withdrawal in Non-ischaemic Cardiomyopathy Study

Conditions
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Heart Failure

Intervention / Treatment
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* Drug: Aspirin
* Other: withdrawal of aspirin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Over the age of 18 years In sinus rhythm at the time of randomisation Have a LVEF <0.40 Are receiving ACE inhibitor or ARB, β-blocker and diuretic therapy at the optimal doses. Has been receiving aspirin therapy for at least 3 months Documented non-ischaemic heart failure. Must have at least 1 of the following: Willing and able to provide informed consent Exclusion Criteria: Ischaemic cardiomyopathy High risk of thromboembolism, including atrial fibrillation previous thromboembolic event including left ventricular thrombus, stroke or transient ischaemic attack, myocardial infarction, deep venous thrombosis or pulmonary embolus an underlying condition which predisposes to thromboembolism e.g. amyloidosis idiopathic dilated cardiomyopathy and a history of venous thromboembolism in a first degree relative Systolic BP >160mmHg Uncorrected primary valvular disease Active myocarditis Obstructive or restrictive cardiomyopathy Exercise capacity limited by factors other than cardiac dyspnoea Hospitalisation within one month of randomisation Severe primary pulmonary (VC <1.5L), renal or hepatic disease

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Aspirin<br>Current dose of aspirin for 12 weeks | Drug: Aspirin<br>* Current dose<br>|
| Experimental: Withdrawal arm<br>Withdrawal of aspirin for 12 weeks | Other: withdrawal of aspirin<br>* Stopping current dose of aspirin<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in NYHA class |  | Week 12 and week 24 | 
| Change in 6 minute walk test |  | 12 week and 24 weeks | 
| Change in BNP |  | 12 weeks and 24 weeks | 
| change in Quality of Life questionnaire |  | 12 weeks and 24 weeks |