Topical Analgesic Versus Saline Mouth Rinses in Post Extraction Healing

Study Overview
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Brief Summary
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There is no evidence based guidelines on using saline rinses for post extraction oral care among hypertensives. Similarly, benefit of orally dissolved topical analgesics in addition to orally administered analgesic is questionable.

Detailed Description
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Objective: To compare the post dental extraction healing among subjects who took simple analgesic tablets dissolved in water versus those who used saline rinses post operatively. Methods: A study will be done among patients who underwent dental extractions at AKHSP dental clinic, Karachi, Pakistan. Carious, periodontally mobile, traumatized or broken down teeth among 20-70 years old in either gender will be included. In addition to the routine prescription of antibiotics and oral analgesics, the hypertensive subjects (n=20) will be advised to take dissolved Aspirin tablet as an oral care while non-hypertensive will be divided into two sub groups (n=20 each), advised saline mouth rinses or dissolved Aspirin for 5 days, respectively. The outcome (healing of the extraction socket) will be evaluated 7 days from the day of extraction on an ordinal scale.

Official Title
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Comparison of Topical Analgesic With Saline Rinses in Post Extraction Healing Among Hypertensive and Non-Hypertensive Patients

Conditions
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Tooth Extraction Site Healing

Intervention / Treatment
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* Drug: Aspirin Powder
* Drug: Normal saline


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Carious, periodontally mobile, traumatized or broken down teeth needing extraction Age 20-70 years, both genders Exclusion Criteria: Diabetes Osteoporosis, metabolic bone disease etc. Radiation therapy or chemotherapy.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: hypertensives on Aspirin mouthwash<br> | Drug: Aspirin Powder<br>* Aspirin powder to be dissolved in water and to be used as mouthwash twice daily for 7 days after tooth extraction.<br>* Other names: Acetyl salicylic acid;|
| Active Comparator: non-hypertensives on Aspirin mouthwash<br> | Drug: Aspirin Powder<br>* Aspirin powder to be dissolved in water and to be used as mouthwash twice daily for 7 days after tooth extraction.<br>* Other names: Acetyl salicylic acid;|
| Active Comparator: hypertensives on Saline mouthwash<br> | Drug: Normal saline<br>* Normal saline to be used as mouthwash twice daily for 7 days after tooth extraction among non-hypertensive subjects.<br>* Other names: Saline;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Healing of the extraction socket | = healed or healing well = incomplete healing but progressing = poorly healed open margins and readily bleeding | Seven days from the day of extraction |