Effects of a Resistance Training Period on Blood Pressure of Hypertensive Elderlies: Influence of the Polymorphism of the Angiotensin Converting Enzyme

Study Overview
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Brief Summary
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The study aimed to evaluate the chronic effects of resistance training on blood pressure and biochemical exams in hypertensive elderlies and the influence of the polymorphism of the angiotensin converting enzyme in these response.

Detailed Description
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To investigate the chronic effects of resistance training on blood pressure and biochemical exams in elderly, 135 hypertensive elderlies were divided into 2 groups: trained and control. The trained group was submitted to a resistance training period. Before the 16 weeks ACE gene was genotyped (PCR). Before and after 16 weeks, blood pressure (ambulatory), HDL-cholesterol, Total cholesterol, Glycemia, Triacylglycerol (colorimetric assay) and plasminogen activator inhibition (PAI-1), intercellular adhesion molecule (ICAM-1), vascular endothelial cell adhesion molecule (VCAM-1), Adiponectin, tumor necrosis factor alpha (TNF-alpha), C Reactive Protein, Angiotensin II, Angiotensin Converting Enzyme, Angiotensin 1-7, (ELISA assay) were measured.

Official Title
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Effects of a Resistance Training Period on Blood Pressure of Hypertensive Elderlies: Influence of the Polymorphism of the Angiotensin Converting Enzyme

Conditions
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Hypertension

Intervention / Treatment
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* Behavioral: Resistance training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Hypertensives Age 60 to 85 years Nonactive Exclusion Criteria: Orthopedic problems or other problem that prevented the exercises Change in drug treatment during protocol Absence in more than 25% of the exercise sessions

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Resistance training<br>Resistance training performed three times at week for 16 weeks, in 8 exercises for the main muscles, the protocol of 3 sets of 10 repetitions with intensity of 50% of 1 maximum repetition (MR). | Behavioral: Resistance training<br>* Resistance training performed three times at week for 16 weeks, in 8 exercises for the main muscles, the protocol of 3 sets of 10 repetitions with intensity of 50% of 1 maximum repetition (MR).<br>|
| No Intervention: Control<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood Pressure | Blood pressure was measured by Ambulatorial Monitoring Blood Pressure before and after 16 weeks of intervention. | 16 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HDL-cholesterol | HDL-cholesterol was analyzed by colorimetric assay, before and after 16 weeks of intervention. | 16 weeks | 
| Total Cholesterol | Total cholesterol was analyzed by colorimetric assay, before and after 16 weeks of intervention. | 16 weeks | 
| Glycemia | Glycemia was analyzed by colorimetric assay, before and after 16 weeks of intervention. | 16 weeks | 
| Triacylglycerol | Triacylglycerol was analyzed by colorimetric assay, before and after 16 weeks of intervention. | 16 weeks | 
| PAI-1 | PAI-1 was analyzed by ELISA assay, before and after 16 weeks of intervention. | 16 weeks | 
| ICAM-1 | ICAM-1 was analyzed by ELISA assay, before and after 16 weeks of intervention. | 16 weeks | 
| VCAM-1 | VCAM-1 was analyzed by ELISA assay, before and after 16 weeks of intervention. | 16 weeks | 
| Adiponectin | Adiponectin was analyzed by ELISA assay, before and after 16 weeks of intervention. | 16 weeks | 
| TNF alpha | TNF alpha was analyzed by ELISA assay, before and after 16 weeks of intervention. | 16 weeks | 
| C Reactive Protein | C Reactive Protein was analyzed by ELISA assay, before and after 16 weeks of intervention. | 16 weeks | 
| Angiotensin II | Angiotensin II was analyzed by ELISA assay, before and after 16 weeks of intervention. | 16 weeks | 
| Angiotensin Converting Enzyme | Angiotensin Converting Enzyme was analyzed by ELISA assay, before and after 16 weeks of intervention. | 16 weeks | 
| Angiotensin 1-7 | Angiotensin 1-7 was analyzed by ELISA assay, before and after 16 weeks of intervention. | 16 weeks |