Pulmonary and Cardiac Ultrasound During Weaning From Mechanical Ventilation

Study Overview
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Brief Summary
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Prospective observational clinical multicentric study in ICU with ventilated patients requiring chest ultrasound analysis.

Detailed Description
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Prospective observational clinical multicentric study on ICU ventilated patients requiring chest ultrasound analysis during weaning from mechanical ventilation with 48 hours of follow-up. Studying variations of cardiac markers

Official Title
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Pulmonary and Cardiac Ultrasound During Weaning From Mechanical Ventilation

Conditions
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Adult Patients Ventilated More Than 48 h, Stable Respiratory and Hemodynamic Conditions for SBT, Consent of Patients, Arterial Line

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Adult patients ventilated more than 48 h Stable respiratory and hemodynamic conditions for SBT Consent of patients Arterial line Exclusion Criteria: Laryngeal dyspnea Tracheostomy Arythmya No echogenicity Paraplegia >T8

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients requiring ventilation<br> | |
| patients who weaned permanently<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Compare the change in pulmonary aeration during the test of weaning from mechanical ventilation (before, at the end, and 4-6 h after) between patients requiring re-ventilation before the 48th hour, and those weaned permanently. | Compare the change in pulmonary aeration during the test of weaning from mechanical ventilation (before, at the end, and 4-6 h after) between patients requiring re-ventilation before the 48th hour, and those weaned permanently. | before, at the end, and 4-6 h after | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Studying variations, during weaning from mechanical ventilation, of pressure of left ventricle filling (E / Ea) coupled with those of plasma BNP. | Studying variations, during weaning from mechanical ventilation, of pressure of left ventricle filling (E / Ea) coupled with those of plasma BNP. | in the 4-6 early hours | 
| Assessing the effects of E / Ea and BNP variations on the success or failure in the 4-6 early hours. | Assessing the effects of E / Ea and BNP variations on the success or failure in the 4-6 early hours. | in the 4-6 early hours. | 
| Compare the variations of lung ultrasound score during the test of the weaning from mechanical ventilation between patients failed the spontaneous breathing test (SBT) and those extubated after successful SBT. | Compare the variations of lung ultrasound score during the test of the weaning from mechanical ventilation between patients failed the spontaneous breathing test (SBT) and those extubated after successful SBT. | in the 4-6 early hours | 
| Comparison of levels epithelial and endothelial markers |  | at h0, h1, h4, h6 | 
| Constitution serum bank for epithelial (sRAGE) markers dosages |  | at h0, h1, h4, h6 | 
| constitution serum bank for endothelial (angiopoietin) markers dosages |  | at h0, h1, h4, h6 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Weaning from mechanical ventilation, BNP, Lung ultrasound, Echocardiography