Portal Vein Resection in Pancreatic Neuroendocrine Tumours

Study Overview
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Brief Summary
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The limited evidence on the value of portal vein resection in patients with borderline resectable and/or locally advanced PanNENs is an incentive to carry out a retrospective multicentre study amongst centres with specific interest in the management of PanNENs and with experience on vascular reconstruction. Unlike previous studies on pancreatic cancer, it is more difficult to standardise the comparative parameters as the definition of borderline resectable disease has never been published for PanNENs. Similarly, different histological classifications make impossible to collect data exclusively on T3 tumours. Therefore, we aim to compare the short and long-term outcomes (including the impact of the histological depth of vascular invasion on survival) between patients undergoing standard PD and PD with portal vein resection for PanNENs, (regardless of T stage), by collecting and analysing retrospective data in this single centre study

Official Title
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Vascular Resection During Pancreaticoduodenectomy for Pancreatic Neuroendocrine Neoplasms (PanNENs): a Comparative Single Centre Study

Conditions
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Pancreas Neoplasm, Neuroendocrine Tumors

Intervention / Treatment
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* Procedure: Portal vein resection / reconstruction


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients undergoing pancreaticoduodenectomy (Whipple's or Pylorus Preserving Pancreaticoduodenectomy) for sporadic PanNENs of the head of the pancreas of any stage (R0 or R1 resections) operated from 1st January 2007 up to 31st December 2016 inclusive. Exclusion Criteria: Multiple Neuroendocrine Neoplasia (MEN) syndrome or other genetic background Age <18 years old Total pancreatectomy or different operation rather than PD R2 Resections

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Portal vein resection / reconstruction|Portal vein resection and reconstruction, with or without concommitant arterial resection|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression-Free Survival | Time from surgery to disease progression, or death or completion of follow up | total of 2 years retrospective follow up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Morbidity and mortality rate | Postoperative morbidity and mortality | total of 2 years retrospective follow up | 
| Histology predictive value | Predictive value of histologically proven invasion of the portal vein adventitia | total of 2 years retrospective follow up | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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portal vein resection, pancreatic surgery