The Relationship Between the Tumor Markers and Interstitial Lung Disease

Study Overview
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Brief Summary
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The serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), CA125 are often increased in interstitial lung disease patients. This study was undertaken to investigate the source of these serum tumor markers.

Detailed Description
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The serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), CA125 are often increased in interstitial lung disease patients. This study was undertaken to investigate the source of these serum tumor markers.We hypothesis that these tumor markers are released from the lung. The broncholveolr lvge fluid levels of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), CA125 were measured in the interstitial lung disease patients before lung transplantation. The immunohistochemical test was performed in the specimen lung after lung transplantation.

Official Title
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The Relationship Between the Tumor Markers and Interstitial Lung Disease

Conditions
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the Relationship Between the Tumor Markers and Interstitial Lung Disease Patients

Intervention / Treatment
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* Other: No Intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria 1.Interstitial lung disease patients for lung transplantation - Exclusion Criteria: tumor Interstitial lung disease patients could not be performed by lung transplantation

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| interstitial lung disease patients<br>interstitial lung disease patients who need lung transplantation | Other: No Intervention<br>* No Intervention<br>|
| non- interstitial lung disease patients<br>non- interstitial lung disease patients who need thoracic surgery to remove pneumatocele | Other: No Intervention<br>* No Intervention<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| serum levels of carcinoembryonic antigen (CEA) | serum levels of carcinoembryonic antigen (CEA) | 6months | 
| serum levels of carbohydrate antigen 19-9 (CA19-9) | serum levels of carbohydrate antigen 19-9 (CA19-9) | 6months | 
| serum levels of carbohydrate antigen 125(CA125) | serum levels of carbohydrate antigen 125(CA125) | 6months | 
| The alveolar lavage fluid levels of carcinoembryonic antigen (CEA) | The alveolar lavage fluid levels of carcinoembryonic antigen (CEA) | 1 week | 
| The alveolar lavage fluid levels of carbohydrate antigen 19-9 (CA19-9) | The alveolar lavage fluid levels of carbohydrate antigen 19-9 (CA19-9) | 1 week | 
| The alveolar lavage fluid levels of carbohydrate antigen 125 | The alveolar lavage fluid levels of carbohydrate antigen 125 | 1 week | 
| The lung tissue levels of carcinoembryonic antigen (CEA) | The lung tissue levels of carcinoembryonic antigen (CEA) | 1 week | 
| The lung tissue levels of carbohydrate antigen 19-9 (CA19-9) | The lung tissue levels of carbohydrate antigen 19-9 (CA19-9) | 1 week | 
| The lung tissue levels of carbohydrate antigen 125 | The lung tissue levels of carbohydrate antigen 125 | 1 week | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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carcinoembryonic antigen, carbohydrate antigen 19-9, carbohydrate antigen 125