Urinary Tract Infection in Patients With Chronic Kidney Disease

Study Overview
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Brief Summary
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This study aims to investigate the etiology and associated risk factors for UTI in Egyptian chronic kidney disease patients. In addition, to identify the isolated micro-organisms and their sensitivity patterns for better anticipation of treatment regimen.

Detailed Description
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Chronic kidney disease (CKD) patients are at higher risk of urinary tract infections (UTI), as CKD is a state of chronic inflammation, metabolic disturbance and impaired immunocompetence. Moreover, patient with CKD are usually of advanced age and suffer from other comorbidities such as diabetes, hypertension, obesity, and cardiovascular diseases, which also add to their risk of infection. UTI comprises heterogeneous conditions ranging from mild cystitis, easily treated with oral antibiotics, to life-threatening sepsis and multiple organ failure. There is scarce information about risk factors of recurrence of UTI and infection with multidrug-resistant organisms in the Egyptian population.

Official Title
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Urinary Tract Infection in Patients With Chronic Kidney Disease: A Retrospective Observational Study at Outpatient Nephrology Clinics

Conditions
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Urinary Tract Infections, Chronic Kidney Diseases

Intervention / Treatment
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* Other: Patients with urinary tract infection and chronic kidney disease


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Males and non-pregnant females aged ≥ 18 years old Patients with CKD stages (G1 to G4) Patients diagnosed with UTI due to urine culture Exclusion Criteria: Non-CKD patients pregnant females CKD patients on immunosuppressant agents ESRD patients on hemodialysis Patients with structural abnormalities which make them liable to frequent UTI

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Patients with urinary tract infection and chronic kidney disease|The data that will be collected from the electronic patient records at the clinics through a google form will include sociodemographic (age, sex, weight and occupation), comorbidities (e.g., HTN, DM), medications used, renal functions (serum creatinine, and CKD stage calculated by 2021 CKD-EPI creatinine equation), and in case of positive urine culture (type of microorganism and antibiogram).|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prevalence of UTI in CKD patients | percentage of UTI in CKD patients | records will be retrospectively screened from January 2019 till September 2022 | 
| isolated microorganisms causing UTI in CKD patients | isolated microorganisms in cultures causing UTI in CKD patients | records will be retrospectively screened from January 2019 till September 2022 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| sensitivity pattern of urine cultures in CKD | describe sensitivity pattern of urine cultures in CKD | records will be retrospectively screened from January 2019 till September 2022 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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urinary tract, infection, chronic kidney disease, UTI, CKD