Value of PET/CT Imaging in the Diagnosis of Permanent Central Venous Catheters Infection

Study Overview
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Brief Summary
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The study hypothesis is that F-18-FDG PET/CT and microcalorimetry might have a diagnostic value in the detection of permanent central venous catheters (PCVC) infection when conventional means of PCVC infection detection are non-conclusive.

Detailed Description
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Permanent central venous catheters are frequently infected and therefore need surgical removal. When a clear diagnostic for infection cannot be defined, catheter removal might be at risk for the patient, for the therapeutic follow-up and in terms of costs. PET/CT and microcalorimetry might help giving conclusive diagnostic of catheter infection.

Official Title
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Prospective Study on the Usefulness and Diagnostic Value of F-18-FDG PET/CT in the Diagnosis of Permanent Central Venous Catheters Infection

Conditions
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Infection

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with confirmed catheter infection requiring surgical removal patients with probable catheter infection requiring surgical removal patients with planned removal of uninfected catheter ≥18years old Exclusion Criteria: extreme claustrophobia pregnancy and breastfeeding severe septicemia

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Confirmed CVCP infection before removal<br>Patients with permanent central venous catheter infection confirmed by conventional method | |
| Presumed CPVP infection before removal<br>Patients with probable permanent central venous catheter infection (standard methods for infection detection not conclusive) | |
| Uninfected CVCP before removal<br>Patients with planned permanent central venous catheter removal (no infection) | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnostic value (sensitivity and sensibility, positive/negative predictive value) of F-18-FDG PET/CT imaging in the detection of CVCP infection | To determine the clinical use of PET/CT in the detection of catheter infection by comparing PET/CT imaging results to standard means of catheter infection detection (i.e. clinical signs and hemoculture [positive or negative]) | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnostic value (sensitivity and sensibility, positive/negative predictive value) of microcalorimetry in the detection of CVCP infection | To determine the clinical use of microcalorimetry in the detection of catheter infection by comparing microcalorimetry results to standard means of catheter infection detection (i.e. clinical signs and hemoculture [positive or negative]) | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Infection, Permanent central venous catheter, Device Related