Fractional CO2 Laser Combined With PRP Fluid Versus Gel in Treatment of Acne Scars

Study Overview
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Brief Summary
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This study is to test the efficacy of fractional laser combined with either PRP fluid or PRP gel in the treatment of atrophic acne scars

Detailed Description
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The study will include 20 patients, treated with fractional CO2 laser plus PRP fluid on one side of the face and fractional CO2 laser plus PRP gel on the other side. Choosing which side of the face will be injected with PRP fluid and which side will be injected with PRP gel will be chosen according to a randomization table for each patient.

Official Title
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Fractional CO2 Laser Combined With Platelet Rich Plasma Fluid Versus Gel Form in Treatment of Atrophic Acne Scars: A Randomized Clinical Trial

Conditions
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Atrophic Acne Scar

Intervention / Treatment
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* Combination Product: Fractional laser with PRP fluid or PRP gel


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age above 18 Both genders Skin types III - V Willingness and ability to comply with the requirements of the protocol Atrophic acne scars Exclusion Criteria: Patients with active acne Patients with herpes labialis, bacterial infections, other infections such as HBV. HCV or HIV. Oral isotretinoin use in the previous 6 months Pregnancy Tendency to keloid formation Patients with severe systemic illness or malignancy Patients with connective tissue diseases Patients with bleeding tendencies or any other hematological disease

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Fractional laser with PRP fluid<br>Fractional CO2 laser then the PRP is injected afterwards | Combination Product: Fractional laser with PRP fluid or PRP gel<br>* 20 participants divided into 2 groups of 10 10 participants will do Fractional laser with PRP fluid sessions and 10 participants will do Fractional laser with PRP gel<br>|
| Active Comparator: Fractional laser with PRP gel<br>Fractional CO2 laser then the PRP gel is injected afterwards | Combination Product: Fractional laser with PRP fluid or PRP gel<br>* 20 participants divided into 2 groups of 10 10 participants will do Fractional laser with PRP fluid sessions and 10 participants will do Fractional laser with PRP gel<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Test which combination is more effective, fractional laser with PRP fluid or fractional laser with PRP gel | Effectiveness of each combination will be measured with OCT, depth of a fixed scar on each side of the face will be measured at baseline and then compared with 1 month after the last session and 3 months after the last session | one year |