4D-flow MRI to Assess Left Ventricular Obstruction in Hypertrophic Cardiomyopathy

Study Overview
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Brief Summary
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Hypertrophic cardiomyopathy (HCM) is a frequent cardiac pathology with an estimated prevalence of 1/500 in France. The main risk factor for sudden death in this pathology is the presence and extent of left ventricular obstruction. To date, the only method allowing a reliable assessment of the extent of left ventricular obstruction is Doppler echocardiography. All patients with HCM should undergo cardiac magnetic resonance imaging (MRI) to confirm the diagnosis and for the detection of fibrosis, but conventional sequences cannot reliably assess the obstruction. 4D-flow MRI provides a complete coverage of an entire volume with the ability to simultaneously measure the outputs of all vessels within that volume in a single sequence and might be able to quantify left ventricular obstruction. The main objective of this study is to compare the quantification of left ventricular obstruction in hypertrophic cardiomyopathy by Doppler echocardiography and 4D flow MRI.

Official Title
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4D Flow Cardiac MRI Velocity Mapping in Patients With Hypertrophic Cardiomyopathy: Assessment of the Severity of the Left Ventricular Obstruction and Comparison With Echocardiography

Conditions
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Hypertrophic Cardiomyopathy, Obstruction, Echocardiography

Intervention / Treatment
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* Other: cardiac magnetic resonance imaging (MRI)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥ 18 years old Presence of a Hypertrophic cardiomyopathy (HCM) Affiliation to a social security program Ability of the subject to understand and express opposition Exclusion Criteria: Major obesity (> 140 kg) not allowing the patient to enter the tunnel of the machine whose diameter is less than 70cm, Age < 18, Person under guardianship or curators, Pregnant woman, Allergy to gadolinium chelates, Claustrophobia, Any contraindications to MRI

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: cardiac magnetic resonance imaging (MRI)|Cardiac MRI is a mandatory examination for Hypertrophic cardiomyopathy patients as it provides important information about the presence of fibrosis which is also directly associated with sudden cardiac death.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Value of Correlation coefficient between the maximum gradient obtained by 4D flow MRI and the maximum gradient measured by echocardiography. | Correlation coefficient assessment between the maximum gradient obtained by 4D flow | day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Value of Correlation coefficient between the maximum gradient obtained by 4D flow MRI and the maximum gradient measured by phase-contrast | Correlation coefficient assessment between the maximum gradient obtained by 4D flow MRI and the maximum gradient measured by phase-contrast | day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Hypertrophic Cardiomyopathy, 4D-flow magnetic resonance imaging, Obstruction, maximal gradient, echocardiography