The Association Between Adenomyosis/Uterine Myoma and Lower Urinary Tract Symptoms

Study Overview
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Brief Summary
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The aim of this study is to assess the relationship between adenomyosis/myoma and lower urinary tract symptoms, sexual function and gastrointestinal symptoms.

Detailed Description
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All outpatient patients were found to have >3 cm uterine myoma or adenomyosis were invited to participate in this study. The size and location of uterine myoma or adenomyosis and the uterus should be assessed by ultrasonography. Besides, all enrolled female patients will be asked to complete overactive bladder symptom score, female bladder function (UDI-6 & IIQ-7), female sexual function index, and bowel incontinence assessment questionnaires. In addition, patients who underwent surgeries for myoma or adenomyosis will be requested to complete the above questionnaires at 3 months after surgery. Women with intact uterus should be assessed again by ultrasonography. At least 30 women with age and body mass index matched and without uterine myoma or adenomyosis will be invited to participate in this study as the control group.

Official Title
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The Association Between Adenomyosis/Uterine Myoma and Lower Urinary Tract Symptoms and Gastrointestinal Symptoms

Conditions
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Adenomyosis, Uterine Leiomyoma

Intervention / Treatment
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* Procedure: myomectomy or adenomyomectomy


Participation Criteria
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Eligibility Criteria
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<Women with myoma or adenomyosis> Inclusion Criteria: >20 years old. Myoma: women with >3 cm uterine myoma Adenomyosis: women with uterus having several dark area (lacunar areas) in one uterine wall or thickening uterine wall <The control group> Inclusion criteria: >20 years old. Women without myoma or adenomyosis <Both groups> Exclusion Criteria: The patient has a lower urinary tract infection or acute intestinal inflammation. Previous surgery for the bladder or urethra. History of urinary tract stones or tumors.

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Women with uterine myoma<br>Women with uterine myoma | Procedure: myomectomy or adenomyomectomy<br> <br> |
| Women with adenomyosis<br>Women with adenomyosis | Procedure: myomectomy or adenomyomectomy<br> <br> |
| Women without uterine myoma or adenomyosis<br>Control group | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The corrleation coefficient between the size of myoma and Overactive Bladder Symptoms Scores | The Spearman's correlation between the size of uterine myoma and the score of Overactive Bladder Symptoms Scores | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The corrleation coefficient between the size of myoma and the presence of constipation/diarrhea | The Spearman's correlation between the size of uterine myoma and the presence of constipation/diarrhea | 12 weeks | 
| Comparison of Overactive Bladder Symptoms Scores between the adenomyosis group and the control group | Comparison of Overactive Bladder Symptoms Scores between the adenomyosis group and the control group by Wilcoxon rank-sum test | 12 weeks | 
| Comparisons of the constipation/diarrhea rates between the adenomyosis group and the control group | Comparisons of the constipation/diarrhea rates between the adenomyosis group and the control group by Chi-square test or Fisher's exact test | 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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adenomyosis, uterine myoma, lower urinary tract symptoms, sexual dysfunction, gastrointestinal symptom