Predictive Models for Radiation-induced Side Effects in Head and Neck Cancer Based on Single Nucleotide Polymorphisms (SNP)

Study Overview
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Brief Summary
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Background of the study: Swallowing dysfunction and xerostomia are the most frequently reported radiation-induced side effects (RISE) after (chemo) radiation ((CH) RT) in head and neck cancer (HNC) patients and have a major impact on the general dimensions of quality of life (QoL). In radiation0oncology, normal tissue complication probability (NTCP) models based on dose-volume parameters being used to determine the risk of acute and late RISE. NTCP models containing genetic determinants of radiosensitivity, such as single nucleotide polymorphisms (SNPs), may improve model performance and thus enable more individualized radiotherapy. Information of the predictive value of SNPs or SNP signatures among patients with HNC is currently not available. Objective of the study: The main objective of this project will be to test the hypothesis that SNP profiles can improve the performance of predictive models for the most frequently reported late RISE, i.e. dysphagia, in HNC patients after curative (CH) RT. Secondary objectives will be improvement of NTCP models for HNC patients by adding SNP profiles predictive of (1) acute mucositis; (2) acute dysphagia; (3) salivary dysfunction; (4) acute xerostomia; (5) late xerostomia; (6) osteoradionecrosis; (7) hypothyroidism; (8) patient-rated HNC symptoms and ; (9) quality of life.

Official Title
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Predictive Models for Radiation-induced Side Effects in Head and Neck Cancer Based on Single Nucleotide Polymorphisms (SNP)

Conditions
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Head and Neck Cancer

Intervention / Treatment
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* Other: Blood sampling


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Histological proven head and neck cancer Primary site in the oral cavity, oropharynx, hypopharynx, nasopharynx, paranasal sinuses, and/or salivary glands Treatment with curative intent with primary or postoperative radiotherapy either or not combined with systemic treatment Northern European ethnicity (ethnicity is a known confounder in SNP association studies) Willing and able to comply with the study prescriptions 18 years or older No prior radiation (in the head and neck area) Patients must have sufficient knowledge of the Dutch language to understand the meaning of the study as described in the patient information Have given written informed consent before patient registration Exclusion Criteria: Prior radiotherapy

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Blood sampling|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in acute toxicity | Dysphagia; mucositis; salivary dysfunction; xerostomia | At 1,2,3,4,5,6,7 and 12 weeks after first day of radiation therapy | 
| Change in late toxicity | Dysphagia; xerostomia; osteoradionecrosis; hypothyroidism | At 6,12,18,24,36,48,60 months after last day of completion of treatment | 
| Change in patient-rated symptoms | Assessed by questionnaires | At 1,2,3,4,5,6,7 and 12 weeks after first day of radiation therapy | 
| Change in patient-rated Quality-of-Life | Assessed by questionnaires | At 6,12,18,24,36,48,60 months after last day of completion of treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Head and Neck neoplasms, Genome-wide association study, Polymorphism, single nucleotide, Toxicity