Testing the Persuasiveness of Pro-inoculation Arguments

Study Overview
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Brief Summary
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The investigators will recruit a national sample of parents of 7-10-year-olds to complete an argument strength ranking for either a simple forwarding message or between 3 and 6 randomly selected arguments from an overall set of 50 to 100 messages identified from various online sources. Parents will rate each message they see on measures of perceived argument strength/PME. Parents will also answer sociodemographic questions and then rank the believability of a set of anti-vaccine messages identified in a different study. Study findings will contribute valuable information to understanding the effectiveness of different inoculation messages.

Official Title
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Message Testing Protocol for Misinformation Concerns

Conditions
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Vaccination Hesitancy, Human Papillomavirus Vaccination, Vaccine Refusal

Intervention / Treatment
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* Behavioral: Argument inoculation messages
* Behavioral: Simple forewarning message


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male or female parent or legal guardian of an adolescent ages 7-10 Age eligible child has not yet received any doses of the HPV vaccine Resides in the United States English speaking Completed informed consent Exclusion Criteria: Unable to read English at a 6th grade literacy level Age < 18 Does not have a child within the age range of 7-10 Age-eligible child has received 1 or more doses of the HPV vaccine Does not have a social media account on one or more of the following platforms OR does not read online news stories: Twitter, Instagram, YouTube, Facebook (feasibility testing only - survey participation will not have this exclusion criteria) Unwilling or unable to provide informed consent to study participation

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: randomized discrete choice modeling experiment design
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Simple forewarning message<br>Participants will receive a simple short forewarning message to read and rate. | Behavioral: Simple forewarning message<br>* Participants will be presented with a simple forewarning message.<br>|
| Experimental: Argument inoculation messages<br>Participants will view a random sample of 3 text-only short messages (from a corpus of 100 arguments) to read and rate. | Behavioral: Argument inoculation messages<br>* Participants will then be presented with arguments randomly selected by the Qualtrics software algorithm from the full set of messages.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Argument strength/PME | Arguments will be rated for their argument strength/message effectiveness | The outcome measure will be assessed immediately after the participant has viewed each pro-HPV vaccine message if they are in the multiple message condition, or the simple message if they are in the simple message condition stimuli during the survey. | 
| Misinformation believability | A rating of the believability/ credibility of vaccine misinformation | The outcome measure will be assessed immediately after the participant has viewed each misinformation message during the survey. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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misinformation, HPV vaccine, vaccine hesitancy