Nutrition, Physical Activity, and Cognition in Breast Cancer Survivors

Study Overview
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Brief Summary
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The purpose of this study is to examine the relationship between nutrition, physical activity and brain function in breast cancer survivors.

Detailed Description
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The current study will examine the potential relationships between physical activity, dietary intake, body composition and cognition in breast cancer cancer survivors and age-matched women without a previous cancer diagnosis. Additionally, we will measure blood inflammatory markers to explore the relationship between lifestyle factors and inflammation. The study involves two, 1hr appointments at Texas State University. The first visit will include cognitive testing and body composition assessment. Participants will be given an activity monitor to wear for one week and a packet of questionnaires to complete at home. At the second visit, a fasted blood sample will be collected, and participants will complete a food frequency questionnaire.

Official Title
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Lifestyle Factors, Inflammation, and Cognition in Breast Cancer Survivors

Conditions
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Breast Cancer, Cognitive Impairment, Cognition

Intervention / Treatment
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* Other: no intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Breast cancer survivors must have completed primary treatment (chemotherapy, radiation therapy or both) within past 60 months age-matched controls must have no previous cancer diagnosis Female no history of stroke, heart attack or transient ischemic attack not currently pregnant; can speak, read, and write English can attend all testing sessions not blind or legally blind; nonsmoker no current use of computer-based brain training games (e.g. Lumosity ®, BrainHQ ®). Exclusion Criteria: male < 30 or > 70 years of age breast cancer survivor > 60 months from last treatment or currently undergoing primary treatment breast cancer survivor never treated with chemotherapy and/or radiation previous cancer diagnosis other than breast cancer

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Breast cancer survivor<br>Inclusion criteria: Female breast cancer survivors (30-70yrs of age) that have completed primary treatment (chemotherapy, radiation therapy or both) within past 60 months | Other: no intervention<br> <br> |
| Control<br>Females (30-70yrs of age) with no previous cancer diagnosis. | Other: no intervention<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognition | A series of computer-based cognitive tasks will be administered via the NIH Toolbox Cognition Battery | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physical Activity | Physical activity will be measured by a waist-worn accelerometer | Baseline | 
| Diet Quality | Diet will be assessed by completion of the online-administered 2005 Block Food Frequency Questionnaire | Baseline | 
| Body Composition (objectively measured) | Body composition will be evaluated by BOD POD assessment | Baseline | 
| Inflammatory Markers | A fasted blood sample will be collected for measurement of inflammatory markers | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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nutrition, physical activity, breast cancer survivor, cognition