Biomarkers in the Evaluation of Chronic Lung Disease

Study Overview
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Brief Summary
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We hypothesize that hypoxia-induced pulmonary vascular remodeling is mediated by macrophage migration inhibitory factor (MIF), that remodeling is in fact the reflection of a chronic inflammatory process, and that MIF may be a useful biomarker of the severity and progression of both ILD and PH.

Detailed Description
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We hypothesize that hypoxia-induced pulmonary vascular remodeling is mediated by macrophage migration inhibitory factor (MIF), that remodeling is in fact the reflection of a chronic inflammatory process, and that MIF may be a useful biomarker of the severity and progression of both ILD and PH. To study this hypothesis, we have two specific aims: To evaluate plasma MIF concentration as a marker of severity in ILD and PH and To determine the utility of breathe condensate analysis in the evaluation of ILD and PH. If we are successful in identifying MIF as a biomarker, it may identify MIF as a useful therapeutic target, as we have shown in other inflammatory disorders.

Official Title
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Biomarkers in the Evaluation of Chronic Lung Disease

Conditions
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Pulmonary Hypertension, Pulmonary Arterial Hypertension, Interstitial Lung Disease

Intervention / Treatment
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* Other: Blood Gas
* Other: Pulmonary Exercise Test
* Other: Spirometry
* Other: Breath Condensate Collector


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subject are at least 18 years of age Subject has confirmed Pulmonary Hypertension and Interstitial Lung Disease Subject are able to complete study procedures, such as spirometry, and Pulmonary Exercise test. Exclusion Criteria: Subject are pregnant Subject is unable to perform tasks associated with study

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy Controls<br>Subjects are made up of healthy adults | Other: Blood Gas<br>* Subject will have both venous and arterial blood draws to assess for the bloods content of MIF<br>Other: Pulmonary Exercise Test<br>* Subject will ride exercise bike to assess their pulmonary function level.<br>Other: Spirometry<br>* To assess subjects lung function<br>Other: Breath Condensate Collector<br>* Subject with use breathing apparatus to allow researchers to collect breath condensate to assess level of MIF in breathe condensate.<br>|
| Affected<br>Subjects have Pulmonary Hypertension | Other: Blood Gas<br>* Subject will have both venous and arterial blood draws to assess for the bloods content of MIF<br>Other: Pulmonary Exercise Test<br>* Subject will ride exercise bike to assess their pulmonary function level.<br>Other: Spirometry<br>* To assess subjects lung function<br>Other: Breath Condensate Collector<br>* Subject with use breathing apparatus to allow researchers to collect breath condensate to assess level of MIF in breathe condensate.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pulmonary Hypertension, Pulmonary Arterial Hypertension, Interstitial Lung Disease, MIF