The Effect of Prebiotics on Endurance Performance

Study Overview
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Brief Summary
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The aim of this study is to investigate the effect of a six-week period personalised food intervention with prebiotic supplementation on intense exercise performance in healthy, recreationally active adults.

Detailed Description
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The study conforms to a randomized, single-blinded, placebo-controlled parallel study design. a prebiotic supplement will be selected based on a participants gut microbiota. 1 sachet of prebiotic or placebo will be given twice a day over a period of 6 weeks. Before the start of the study, a VO2max test will be performed. Subjects will bring faecal samples which is collected at home. A time to exhaustion of approximately 80% of their VO2max will be performed at baseline and after the 6 weeks intervention period.

Official Title
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Modulation of the Intestinal Microbiome, and Its Effects on Endurance Exercise Capacity in Moderately Trained Individuals

Conditions
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Microtia

Intervention / Treatment
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* Dietary Supplement: Prebiotic
* Other: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male or female 18 - 40 y BMI range 18.5 - 25 kg/m2 Recreational active (performing non-competitive physical endurance exercise at least two times per week with a minimum duration of 60 minutes per exercise bout) Exclusion Criteria: Smoking Performing regular resistance training (3+ times per week, carrying out progressive overload training) Subject following an overly imbalanced or restrictive diet as per nutritional advice Participants who received antibiotics in the 90 days prior to the start of the study Self-admitted lactose intolerance Administration of probiotic or prebiotic supplements in the 14 days prior to the study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: The study conforms to a randomized, single-blinded, placebo-controlled parallel study design.
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Prebiotic intervention group<br>Prebiotic supplementation | Dietary Supplement: Prebiotic<br>* 6 weeks of prebiotic supplementation twice a day<br>|
| Placebo Comparator: Placebo control group<br>Maltodextrin | Other: Placebo<br>* 6 weeks of maltodextrin supplementation twice a day<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to Exhaustion | Time on cycle ergometer until exhaustion | From baseline to end of the study (up to max 45 days) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gut microbiota composition | Composition of the gut microbiota by faecal sample analysis | From baseline to end of the study (up to max 45 days) | 
| Plasma short chain fatty acids | Short chain fatty acids in plasma | From baseline to end of the study (up to max 45 days) | 
| Blood glucose | Fasted blood glucose | From baseline to end of the study (up to max 45 days) | 
| Insulin | Fasted insulin | From baseline to end of the study (up to max 45 days) | 
| Intestinal permeability by sugar test | Intestinal permeability measured by a sugar drink test | From baseline to end of the study (up to max 45 days) |