Intrathecal Chloroprocaine for Lower Limb Arthroplasty

Study Overview
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Brief Summary
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This study evaluates the perioperative course in adult patients undergoing total or partial knee arthroplasty, or total hip arthroplasty under chloroprocaine spinal anesthesia.

Detailed Description
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This study evaluates the failure rate of spinal anesthesia, the duration of surgical anesthesia, the needs for complementary intraoperative analgesia, the time for recovery, the incidence of urinary retention, postoperative nausea and vomiting, and length of stay in the recovery room in patients operated for knee or hip arthroplasty under spinal anesthesia with chloroprocaine 50 mg.

Official Title
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Perioperative Outcomes in Patients Received Spinal Chloroprocaine for Hip or Knee Arthroplasty

Conditions
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Lower Limb Arthroplasty Under Chloroprocaine Spinal Anesthesia

Intervention / Treatment
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* Drug: Chloroprocaine Injection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adult patients with spinal anesthesia using 50 mg of chloroprocaine operated for total knee, unicompartment knee or anterior access hip arthroplasty in the period of years 2020 - 2021 Exclusion Criteria: expressed disagreement to to participate after receiving information notice

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| chloroprocaine anesthesia for arthroplasty<br>patients having predicted uncomplicated surgery for total or unicompartment knee arthroplasty of anterior access total hip arthroplasty, operated under spinal anesthesia with 50 mg of chloroprocaine | Drug: Chloroprocaine Injection<br>* Spinal anesthesia with 50 mg of 1% Chloroprocaine<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Spinal anesthesia failure | proportion of patients with the necessity to convert initially planned spinal anesthesia into general anesthesia | Day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hemodynamic instability | proportion of patients with >20% changes in blood pressure and ou heart rate comparing to baseline | Day 0 | 
| Need for sedation | proportion of patients requiring intraoperative sedation for uncomfortable conditions | Day 0 | 
| Surgical block duration | time of regression of sensitive and motor spinal block | Day 0 | 
| PACU analgesia requirement | morphine equivalent requirement in PACU for the postoperative pain | Day 0 | 
| Urinary retention | proportion of patients requiring urinary catheter | 24 hours | 
| Postoperative nausea and vomiting | proportion of patients having nausea and vomiting | 24 hours | 
| Length of stay in recovery room | Length of stay in recovery room | Day 0 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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chloroprocaine, total hip arthroplasty, total knee arthroplasty, unicompartmental knee arthroplasty, spinal anesthesia