Individualized Precise Localization of rTMS on Precentral and Parietal Gyrus

Study Overview
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Brief Summary
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Attention deficit hyperactivity disorder (ADHD) patients have some problem with sustained attention. The dorsal anterior cingulate cortex (dACC) plays a key role for attention control. It has been found that the dACC has strong functional connectivity with ipsilateral motor area and parietal gyrus. Repetitive Transcranial Magnetic Stimulation (rTMS) is a sage and painless technique to activate cortical areas. The deep brain structure can be activated via stimulating superficial cortex by rTMS. For investigating the mechanism of sustained attention, this project is using functional magnetic resonance imaging (fMRI) to individualize the precise localization in motor area and parietal gyrus, and combining rTMS to activate the dACC.

Detailed Description
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Healthy subject is recruiting in this project. High rTMS will be performed. The 10-Hz stimulation is delivered at 100% of the subject's resting motor threshold via 60 trains of 3-s 10-Hz rTMS (30 pulses with 27-s duration per train).

Official Title
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Individualized Precise Localization of rTMS on Precentral and Parietal Gyrus and Its Effects on Dorsal Anterior Cingulate Cortex

Conditions
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Attention Deficit Hyperactivity Disorder

Intervention / Treatment
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* Device: rTMS


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: There are activation in dACC, motor area and parietal gyrus during the task fMRI The head motion less than 2 mm in translation or 2 degrees in rotation in any direction during the resting-state fMRI Exclusion Criteria: Without any neuropsychiatric conditions No head injury or history of epilepsy Not on any medications

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Real rTMS (motor area)<br>Real rTMS targeting motor area for 30 min | Device: rTMS<br>* The 10-Hz stimulation is delivered at 100% of the subject's resting motor threshold via 60 trains of 3-s 10-Hz rTMS (30 pulses with 27-s duration per train).<br>|
| Experimental: Real rTMS (parietal gyrus)<br>Real rTMS targeting parietal gyrus for 30 min | Device: rTMS<br>* The 10-Hz stimulation is delivered at 100% of the subject's resting motor threshold via 60 trains of 3-s 10-Hz rTMS (30 pulses with 27-s duration per train).<br>|
| Experimental: Real rTMS (both brain area)<br>Real rTMS targeting motor area and parietal gyrus for 15 min, separately | Device: rTMS<br>* The 10-Hz stimulation is delivered at 100% of the subject's resting motor threshold via 60 trains of 3-s 10-Hz rTMS (30 pulses with 27-s duration per train).<br>|
| Sham Comparator: Sham rTMS<br>Sham rTMS targeting motor area and parietal gyrus for 15 min, separately | Device: rTMS<br>* The 10-Hz stimulation is delivered at 100% of the subject's resting motor threshold via 60 trains of 3-s 10-Hz rTMS (30 pulses with 27-s duration per train).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| degree of enhanced neuro-activity associated with target-specific treatment | amplitude of low frequency fluctuation | through study completion, an average of 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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fMRI, rTMS, functional connectivity