Characterizations of Gut Microbiota and Postoperative Sleep in Patients Undergoing Heart Valve Surgery With Cardiopulmonary Bypass

Study Overview
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Brief Summary
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The investigators designed a study to assess whether there is any change in gut microbiota and postoperative sleep before and after heart valve surgery with cardiopulmonary bypass.

Detailed Description
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The investigators designed a study to assess whether there is any change in gut microbiota and postoperative sleep before and after heart valve surgery with cardiopulmonary bypass. Firstly, this study aims to characterize the gut microbiota in patients with valve disease treated with surgery. Secondly, it aims to evaluate microbiota and its influence on postoperative sleep.

Official Title
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Characterizations of Gut Microbiota and Postoperative Sleep in Patients Undergoing Heart Valve Surgery With Cardiopulmonary Bypass

Conditions
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Heart Valve Surgery

Intervention / Treatment
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* Device: polysomnography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Ethnic Chinese; Age, 18 to 65 years old; Patients undergoing heart valve surgery with cardiopulmonary bypass Exclusion Criteria: Preoperative Pittsburgh Sleep Quality Index global scores higher than 6 Cognitive difficulties Partial or complete gastrectomy Previous esophageal surgery Previous treated by radiotherapy or surgery Inability to conform to the study's requirements Body mass index exceeding 30 kg/m2 Deprivation of a right to decide by an administrative or juridical entity Ongoing participation or participation in another study <1 month ago Recent (< 3 months prior) use of antibiotics, probiotics, prebiotics, symbiotics, hormonal medication, laxatives, proton pump inhibitors, insulin sensitizers or traditional Chinese medicine

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: polysomnography|Duration of sleep was collected with polysomnography on second postoperative night. (from 20:00pm to 06:00am).|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| gut microbiota | This study will characterize the gut microbiota in one group of 36 patients before and after heart valve surgery | from baseline to postoperative 72 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative sleep | This study will characterize the postoperative sleep measured by polysomnography in one group of 36 patients after heart valve surgery | on the second postoperative night from 20:00 to 6:00 | 
| serum metabolites | This study will characterize the serum metabolites in one group of 36 patients before and after heart valve surgery | from baseline to postoperative 72 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Gut Microbiota, polysomnography