Sleep and Cytokines During Acute Diverticulitis

Study Overview
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Brief Summary
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The purpose of this study is to investigate sleep disturbances during Acute uncomplicated diverticulitis by polysomnography. The investigators hypothesis is the inflammation causes REM(rapid eye movement)-sleep reduction and this is correlated with plasma cytokine levels.

Detailed Description
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An increasing number of experimental studies have showed that inflammation can induce disturbances in sleep architecture, mediated by cytokines. Sleep is important both in health and disease processes and can affect recovery, morbidity and mortality. Studies have been done on sleep disturbances after major and minor GI-surgery but never in relation to none surgical inflammatory diseases, namely acute diverticulitis. This study will investigate sleep architecture by Polysomnography and inflammation by levels of pro inflammatory cytokines in plasma. Following methods will be applied Device: Polysomnograph - Embla Titanium (Natus Medical Incorporated, USA) Procedure: Plasma cytokines (IL-2, IL-6 and TNF(tumor necrosis factor-alfa) Procedure: Plasma CRP(C reactive protein) and leukocytes

Official Title
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the Effects of Inflammatory Cytokines on Sleep During Acute Diverticulitis

Conditions
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Acute Diverticulitis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: CT-verified diverticulitis patients managed by antibiotic treatment at Herlev Hospital Pain and fever occurred less than 72 hours prior to the admission ASA (American Society of Anesthesiologists) score I to III Exclusion Criteria: Surgical intervention needed Complicated diverticulitis Complications in relation to diverticulitis Pain and fever occurred more than 72 hours prior to the admission In anticoagulant treatment and heart rate control treatment Known Autoimmune disease Known medically treated sleep-disorder (insomnia, restless legs etc.) and sleep apnea Shift-work or jetlag Daily use of opioid, psychopharmaca, opioids or anxiolytics (including Hypnotics) Known psychiatry conditions in treatment with psychopharmaca Daily alcohol intake of more than 5 units or drug abuse Missing written consent Diabetes Mellitus Predicted bad compliance Pregnant or breast-feeding Urine or fecal incontinence Severe kidney disease Current cancer

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| acute uncomplicated diverticulitis<br>CT-verified acute uncomplicated diverticulitis managed by antibiotics | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in Sleep architecture during acute uncomplicated diverticulitis from baseline at the remission (30th day) | Sleep architecture measured by Polysomnography (awake, stadium I-IV, REM sleep, sleep latency, awakenings) | 1st, 2nd and 30th nights following the admission | 
| change in cytokine levels in plasma during the acute uncomplicated diverticulitis from baseline levels at remission | the Blood sample is taken prior to night sleep; Cytokines are measured by commercial ELISA-kits | 1st, 2nd and 30th nights following the admission | 
| change in CRP level in plasma during the acute uncomplicated diverticulitis from baseline levels at remission | the Blood sample is taken prior to night sleep; CRP is measured by standardized conventional method | 1st, 2nd and 30th nights following the admission | 
| change in leucocyte level in plasma during the acute uncomplicated diverticulitis from baseline levels at remission | the Blood sample is taken prior to night sleep; Leucocyte is measured by standardized conventional method | 1st, 2nd and 30th nights following the admission |