Prospective Comparison of Cold Polypectomy and Conventional Polypectomy for Small Colorectal Polyps in Patients Taking Antithrombotic Agents

Study Overview
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Brief Summary
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Background: The ideal method to remove small colorectal polyps in patients who are taking antithrombotic agents is unknown. Aim: The aim of this study is to evaluate postpolypectomy bleeding and the complete retrieval rate after the removal by colon snare transection without electrocautery for small polyps in patients who are taking antithrombotic agents. Design: A prospective, consecutive study. Setting: Municipal hospital outpatients. Interventions: Polypectomy by cold snare technique (Cold polypectomy) was performed for colorectal polyps up to 10 mm in diameter in patients who continue to take antithrombotic agents. The primary outcome measure was bleeding within two weeks after polypectomy. Secondary outcome measure was the complete retrieval rate of colorectal polyps based on the pathological examination.

Conditions
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Colorectal Polyps

Intervention / Treatment
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* Procedure: Cold polypectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with colorectal polyps up to 10 mm in diameter. The patients continue to take antithrombotic agents. Exclusion Criteria: patients are less than 20 years old, pregnant, American Society of Anesthesiologists class III and IV, overweight (body weight > 100 kg), or allergic to propofol used or its components (soybeans or eggs), with previous colorectal surgical resection.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Conventional polypectomy<br>All colorectal polyps up to 10 mm found except for tiny hyperplastic polyps in the rectum and distal sigmoid colon are removed with electrocautery. Submucosal injection of some solution before the removal are not performed. | Procedure: Cold polypectomy<br>* All colorectal polyps up to 10 mm found except for tiny hyperplastic polyps in the rectum and distal sigmoid colon are removed. The technique is cold resection of the polyp without tenting and then suction of the transected polyp into a trap followed by submission to histopathological evaluation.<br>* Other names: Cold snare polypectomy;|
| Experimental: Cold polypectomy<br> | Procedure: Cold polypectomy<br>* All colorectal polyps up to 10 mm found except for tiny hyperplastic polyps in the rectum and distal sigmoid colon are removed. The technique is cold resection of the polyp without tenting and then suction of the transected polyp into a trap followed by submission to histopathological evaluation.<br>* Other names: Cold snare polypectomy;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postpolypectomy bleeding | Bleeding within two weeks after polypectomy | 2 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complete retrieval rate of colorectal polyps | The complete retrieval rate of colorectal polyps based on the pathological examination. | 2 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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10 mm in diameter, antithrombotic agents