Cardiac Dysfunction in Critically Ill Patients With COVID-19

Study Overview
=================
Brief Summary
-----------------
Cardiac dysfunction has been reported to be common in patients infected with COVID-19. The aim of this study is to evaluate the clinical importance of cardiac dysfunction in critically ill patients infected with COVID-19.

Detailed Description
-----------------
Cardiac dysfunction has been reported to be common in patients infected with COVID-19. The aim of this study is to evaluate the clinical importance of cardiac dysfunction in critically ill patients with COVID-19. Patients admitted to the intensive care unit, with COVID-19 are examined with echocardiography for assessment of left and right ventricular dysfunction within 72 hours from admission and repeated after four to seven days. Cardiac dysfunction was defined as having either left ventricular (LV) dysfunction, defined as having an ejection fraction <50% and/or regional hypokinesia, or right ventricular (RV) dysfunction, defined as having a tricuspid annular plane excursion (TAPSE) <17mm or a moderate/severe RV dysfunction assessed visually. The cardiac biomarkers troponin and NTproBNP and clinical data are recorded at time of each echo. Mortality status is recorded at 30 days.

Official Title
-----------------
Cardiac Dysfunction in Critically Ill Patients With COVID-19

Conditions
-----------------
Covid19, Left Ventricular Dysfunction, Right Ventricular Dysfunction, Pulmonary Hypertension

Intervention / Treatment
-----------------
* Diagnostic Test: Echocardiography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients admitted to the intensive care unit infected with COVID-19 Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Echocardiography|Echocardiography for assessment of cardiac function|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | All cause death in patients with vs without cardiac dysfunction | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Left ventricular dysfunction | Prevalence of left ventricular dysfunction | Within 72 hours from admission | 
| Right ventricular dysfunction | Prevalence of right ventricular dysfunction | Within 72 hours from admission | 
| Risk-factors | Clinical variables associated with risk of having cardiac dysfunction | Within 72 hours from admission | 
| Cardiac biomarkers | Levels of cardiac biomarkers in patients with vs without cardiac dysfunction | Within 72 hours from admission | 
| Left ventricular dysfunction | Prevalence of left ventricular dysfunction | During ICU-stay | 
| Right ventricular dysfunction | Prevalence of right ventricular dysfunction | During ICU-stay | 
| Risk-factors | Clinical variables associated with risk of having cardiac dysfunction | During ICU-stay | 
| Cardiac biomarkers | Levels of cardiac biomarkers in patients with vs without cardiac dysfunction | During ICU-stay |