The Impact of Red Packed Cells Transfusion on the Main Biological Markers to Determine the Etiology of Anemias

Study Overview
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Brief Summary
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The aim of this work is to study the changes of key assays useful for the understanding of anemia mechanism before and after red packed cells transfusion: iron status, vitamin assays, hemolysis markers.

Detailed Description
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The aim of this work is to study the changes of key assays useful for the understanding of anemia mechanism before and after red packed cells transfusion: iron status, vitamin assays, hemolysis markers. The patient selection criteria are: age > or = 18 years No history of transfusion > or = 2 years Anemia (any etiology known or assumed) Decision of red packed cells transfusion for the current episode Transfusion performed at BEAUJON Hospital Agreement of patient for the study Number of subjects required: 100 patients Study duration and duration of participation for each patient: duration of the study: 1 year for each patient the participation to the study began at baseline after the decision of transfusion and stopped at the second sample ie at least 72 hours after the transfusion of red blood cells. The maximum contribution for one patient is 5 days. Methodology: It is a prospective non interventional monocentric (BEAUJON Hospital) study. Two blood tests will be performed; one before transfusion and the other from 48 to 72 hours after red packed cells transfusion. The following parameters will be measured before and after red packed cells transfusion: Complete blood count (CBC) with reticulocyte count; complete iron status (ferritin, serum iron, transferrin, transferrin saturation), soluble transferrin receptor; serum and intraerythrocytic folate levels, vitamin B12; lactate dehydrogenase (LDH), bilirubin (total and free), haptoglobin, orosomucoid, direct coombs test; creatinine; CRP. The aim of this work is to study the changes of key assays useful for the understanding of anemia mechanism before and after red packed cells transfusion: iron status, vitamin assays, hemolysis markers.

Official Title
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The Impact of Red Packed Cells Transfusion on the Main Biological Markers to Determine the Etiology of Anemias

Conditions
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Anemia

Participation Criteria
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Eligibility Criteria
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INCLUSION CRITERIA: Age > or = 18 years No history of transfusion > or = 2 years Anemia (any etiology known or assumed) Decision of red packed cells transfusion for the current episode Transfusion performed at BEAUJON Hospital Agreement of patient for the study EXCLUSION CRITERIA: Patient who received between the 2 samples, a treatment which can modify the parameters evaluated (iron, vitamin)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| anemia |  | 72 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Anemia, Transfusion, Biological markers