Effects of Breathing Patterns on Post-prandial Vascular Function

Study Overview
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Brief Summary
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The purpose of this study is investigate the effects of two different breathing styles on postprandial vascular function and oxidative stress markers. Participants will complete 2 breathing conditions in random order.

Official Title
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The Effects of Different Breathing Styles on Post High-Fat Meal Blood Vessel Function

Conditions
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Healthy

Intervention / Treatment
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* Behavioral: Normal physiologic rate breathing
* Behavioral: Slow breathing


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • Male participants ages 18-35 years Exclusion Criteria: Infection within the previous 4 weeks Renal disorders Any cardiovascular disorders such as prior myocardial infarction, known coronary artery disease, personal history of stroke, heart failure, cardiac arrhythmias Chronic obstructive pulmonary disease Diabetes Inflammatory bowel disease HIV, rheumatoid arthritis, chronic or other inflammatory conditions Currently taking steroids or other anti-inflammatory medications Current use of nonsteroidal anti-inflammatory drugs Smoking Stage 2 hypertension or higher (systolic BP of 140 mm Hg or higher and/or diastolic BP of 90 mm Hg or higher) Lactose intolerance

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: Each participant will complete 2 different sessions in random order.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Breathing intervention<br>Participants will complete 2-minute breathing exercises following the Breathing App every 15 minutes during a 4-hour postprandial period following high-fat meal consumption. | Behavioral: Normal physiologic rate breathing<br>* 2-minute breathing exercises will be completed every 15 minutes.<br>Behavioral: Slow breathing<br>* 2-minute breathing exercises will be completed every 15 minutes.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in flow-mediated dilation | Ultrasound-derived images of the brachial artery pre- and post-suprasystolic cuff inflation will yield flow-mediated dilation values. These are indices are endothelium-dependent vasodilation. | At baseline and at again 1, 2, 4 hours post high-fat meal consumption | 
| Changes in oxidative stress | Blood draws will be performed and samples will be processed and stored for future biochemical analysis of blood markers indicative of oxidative stress. | Once at baseline and again at 1, 2, and 4 hours post high-fat meal consumption. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Breathing, Yogic breathing