Clinical and Radiological Evaluation of Meniscal Healing After Percutaneous Intra-meniscal Injection of Platelet-rich Plasma (PRP)

Study Overview
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Brief Summary
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Meniscal lesions are a common pathology among athletes, and have an impact on the daily or sporting practice of patients. The consequences of surgical treatment are sometimes heavy. Platelet-rich-plasma (PRP) has been shown to be effective in healing tendon and ligament lesions. PRP has been injected under ultrasound in tendons or intra-articularly for several years. This technique of meniscal percutaneous injection of PRP is now carried out for more than 2 years in our hospital, with satisfactory preliminary results, without any complication. All patients in our study received an intra-meniscal injection of PRP, under echographic control. They were evaluated clinically and by Magnetic Resonance Imaging (MRI) before and at 6 months of the injection. The aim of the study is to evaluate the efficacy of intra-meniscal injection of PRP on the symptomatology of the patients (pain, sport activities and daily life) at 6 months post-treatment.

Official Title
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Clinical and Radiological Evaluation of Meniscal Healing After Percutaneous Intra-meniscal

Conditions
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Meniscus Lesion

Intervention / Treatment
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* Procedure: Intra-meniscal injection of platelet-rich plasma


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: isolated symptomatic meniscal lesion lesion confirmed by MRI grade II or III lesion touching the peripheral involvement of the middle segment, lesion treated by percutaneous intra meniscal PRP's injection IKDC score measured before injection and 6 months post-injection Exclusion Criteria: other painful etiology of the knee emergency surgical management (luxation, bucket handle) or not (indication validated by the surgeon, meniscectomy or meniscal suture) impossibility to perform the procedure (non visible lesion, morphology of the patient, cutaneous infection, coagulation treatment in progress)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients receiving platelet rich plasma<br>The group is composed of patients receiving an intra-meniscal injection of platelet-rich plasma, under echographic control, for isolated meniscal lesion. | Procedure: Intra-meniscal injection of platelet-rich plasma<br>* Intra-meniscal injection of platelet-rich plasma under echographic control<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Variation of International Knee Documentation Committee (IKDC) score | The variation of IKDC score between before injection and 6 months post-injection will be calculated. The IKDC score ranges from 0 to 100 and is interpreted as a measure of function with higher scores representing higher levels of function. | Between 0 and 6 months post injection |