Project RESIST: Evaluating the Effects of Anti-smoking Inoculation Messages Among Young Adult Sexual Minority Women

Study Overview
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Brief Summary
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Project RESIST is an R01 study funded by NCI focused on determining the effects of using culturally tailored inoculation approaches to increase resilience to tobacco marketing influences among young adult sexual minority women ages 18-30 and incorporates critical stakeholder inputs that support later adoption and implementation. The study team is utilizing formative research to design and pre-test anti-smoking messages and two national longitudinal online survey experiments.

Detailed Description
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This study will recruit 3000 young adult sexual minority women (SMW), ages 18-30 years, current smokers (n = 1500) and not current smokers (n = 1500). The study will determine the effects of varying the dose (single vs. multiple), and latency (immediate vs. delayed) of showing participants inoculation anti-smoking messages on smoking and quitting intentions. The study team hypothesize that the multiple exposures (vs. single), and delayed exposure (vs. immediate) will be associated with increased resistance to marketing, reduced smoking intention, and increased quitting intention. The study team will further explore the mechanisms of inoculation effects through emotions, beliefs, and attitudes towards tobacco companies. Participants will be asked to complete a baseline survey and then will receive an anti-smoking message in varying dosages based on the condition they are assigned with a control group receiving no message. Participants will then see a pro-smoking or threat message immediately, one week, or one month late, depending on the condition they were assigned.

Official Title
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Project RESIST: Evaluating the Effects of Anti-smoking Inoculation Messages Among Young Adult Sexual Minority Women

Conditions
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Cigarette Smoking Behavior

Intervention / Treatment
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* Other: Culturally Tailored Anti-Smoking Messages


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Ages 18-30 Woman Identifies as a sexual minority (any sexual orientation other than heterosexual) Lives in the United States Able to take surveys in English Exclusion Criteria: Under 18 or older than 30 Men Heterosexual Lives outside the United States Unable to take the survey in English

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: No Message Condition<br>Participants will receive no anti-smoking messages. They will receive the threat message during the baseline survey. Outcomes will be measured before and immediately after seeing the threat message, and at 1 month. | |
| Experimental: Single Message Immediate<br>Participants will receive a single anti-smoking message followed by the threat message during the baseline survey. Outcomes will be measured before seeing the anti-smoking message and threat message, immediately after seeing the threat message, and at 1 month. | Other: Culturally Tailored Anti-Smoking Messages<br>* Anti-smoking messages will be administered online via a Qualtrics survey.<br>|
| Experimental: Single Message 1 Week Delay<br>Participants will receive a single anti-smoking message during the baseline survey, followed by the threat message one week later in a separate survey. Outcomes will be measured before seeing the anti-smoking message at baseline, immediately after seeing the threat message at 1 week, and at 1 month. | Other: Culturally Tailored Anti-Smoking Messages<br>* Anti-smoking messages will be administered online via a Qualtrics survey.<br>|
| Experimental: Single Message 1 Month Delay<br>Participants will receive a single anti-smoking message during the baseline survey, followed by the threat message one month later in a separate survey. Outcomes will be measured before seeing the anti-smoking message at baseline, and immediately after seeing the threat message at 1 month. | Other: Culturally Tailored Anti-Smoking Messages<br>* Anti-smoking messages will be administered online via a Qualtrics survey.<br>|
| Experimental: Single Message 1 Month Delay, Repeated Exposure<br>Participants will receive a single anti-smoking message during the baseline survey, followed by the threat message one month later. Participants will also receive repeated exposures of a single anti-smoking message at 1, 2, and 3 weeks in separate surveys. Outcomes will be measured before seeing the anti-smoking message at baseline and immediately after seeing the threat message at 1 month. | Other: Culturally Tailored Anti-Smoking Messages<br>* Anti-smoking messages will be administered online via a Qualtrics survey.<br>|
| Experimental: Three Messages Immediate<br>Participants will receive three anti-smoking messages, followed by the threat message during the baseline survey. Outcomes will be measured before seeing the anti-smoking messages and threat message, immediately after seeing the threat message, and at 1 month. | Other: Culturally Tailored Anti-Smoking Messages<br>* Anti-smoking messages will be administered online via a Qualtrics survey.<br>|
| Experimental: Three Messages 1 Week Delay<br>Participants will receive three anti-smoking messages during the baseline survey, followed by the threat message one week later in a separate survey. Outcomes will be measured before seeing the anti-smoking messages at baseline, immediately after seeing the threat message at 1 week, and at 1 month. | Other: Culturally Tailored Anti-Smoking Messages<br>* Anti-smoking messages will be administered online via a Qualtrics survey.<br>|
| Experimental: Three Messages 1 Month Delay<br>Participants will receive three anti-smoking messages during the baseline survey, followed by the threat message one month later in a separate survey. Outcomes will be measured before seeing the anti-smoking messages at baseline, and immediately after seeing the threat message at 1 month. | Other: Culturally Tailored Anti-Smoking Messages<br>* Anti-smoking messages will be administered online via a Qualtrics survey.<br>|
| Experimental: Three Messages 1 Month Delay Repeat Exposure<br>Participants will receive three anti-smoking messages during the baseline survey, followed by the threat message one month later. Participants will also receive repeated exposures of three anti-smoking messages at 1, 2, and 3 weeks in separate surveys. Outcomes will be measured before seeing the anti-smoking messages at baseline and immediately after seeing the threat message at 1 month. | Other: Culturally Tailored Anti-Smoking Messages<br>* Anti-smoking messages will be administered online via a Qualtrics survey.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in intention to quit smoking | Change in intention to quit smoking will be measured using the Burkhalter intention to quit smoking scale. This is a four item scale that measures readiness to cut down or quit smoking in the next 30 days. This will only be measured among current smokers. Lowest mean score is 1 and highest mean score is 7. Higher scores indicate increased intention to quit smoking. | Days 0, 30 | 
| Change in intention to purchase cigarettes | Change in intention to purchase cigarettes will be measured using the Juster single item consumer buying intention scale to measure how likely participants who are not current smokers are to purchase cigarettes. Response options range from 0 to 10 with 10 indicating a higher likelihood of purchasing cigarettes. | Days 0, 30 |