Alcohol, Behavior, and Brain Imaging

Study Overview
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Brief Summary
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To evaluate the relationship of extraversion to both the acute subjective and behavioral effects of alcohol, and the neural reactivity to the anticipation of reward.

Official Title
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Alcohol, Behavior, and Brain Imaging

Conditions
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Alcohol Drinking, Binge Drinking, Drinking Behavior, Substance-Related Disorders, Ethanol, Physiological Effects of Drugs, Central Nervous System Depressants

Intervention / Treatment
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* Drug: Ethanol
* Other: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 21-29 years old 7-30 alcoholic drinks per week (as reported on PHQ or TLFB) At least one binge episode (4 for females/5 for males) per month No 'flushing' reaction to alcohol Females must be on birth control or in the beginning of follicular phase (1-14 days after start of menstruation) BMI 19-26 High school education or greater, fluent in English No night shift work No current or past year Axis I psychiatric disorder including drug/alcohol dependence No current psychopharmacological treatment No lifetime ADHD or prescription for ADHD medication No abnormal EKG, cardiovascular illness, high blood pressure No medical condition or pharmacological treatment for which alcohol is contraindicated Not pregnant, lactating, or planning to become pregnant Smoke <6 cigarettes per day No previous participation in studies that have used the Stop Task (except IDAC) o Previous Stop Task studies: GOI, CAP, STEM, JAM, MACI, PAC, CAM

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 29 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Ethanol<br>Subjects will receive 4 color-coded beverages in green or blue cups, containing ethanol (0.2 g/kg per dose, total dose 0.8 g/kg). | Drug: Ethanol<br>* The 0.8 g/kg body weight dose of oral alcohol (190-proof ethanol) will be divided into 4 servings of 0.2 g/kg each. The 0.8 g/kg dose is equivalent to 4 standard drinks, where a standard drink is defined as one 12 oz beer, one 5 oz glass of wine, or one 1.5 oz shot of 80 proof alcohol. Women will receive a reduced dose (0.68 g/kg) to account for sex differences in total body water<br>|
| Placebo Comparator: Placebo (Juice)<br>Subjects will receive 4 color-coded beverages in green or blue cups, containing placebo (Juice). | Other: Placebo<br>* The placebo beverage will consist of the cranberry or orange juice plus 1% alcohol added as a taste mask. All beverages will be sprayed with an alcoholic mist to provide a strong alcoholic scent.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Stop Signal Task (SST) | The Stop-Signal Task (SST) is a task requiring inhibition of a prepotent motor response. The SST requires participants to respond to a target stimulus as quickly and accurately as possible by pressing a button, but also to withhold their response when they hear an auditory signal. Thus, this task involves a competition between activating and inhibiting processes. The primary outcome variable is change in the stop signal reaction time (SSRT) for the task administered seconds to minutes before and seconds to minutes after stimulation. The theoretical minimum is zero seconds and there is no theoretical maximum. Higher SSRT scores reflect greater impulsivity. | Within an hour post-stimulation condition |