Endocrine Changes in Adults Undergoing Cardiac Surgery

Study Overview
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Brief Summary
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In this prospective study the investigators want to measure the serum level changes of the thyroid hormones (thyroid-stimulating hormone, reverse triiodothyronine, serum free T4), brain natriuretic peptide (BNP), testosterone and sexual hormone binding protein (SHBG) in adults undergoing cardiac surgery and search for correlations different psychosocial factors and analyze the influence on the survival and the length of ICU/hospital stay.

Detailed Description
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In this study the investigators want to analyze routinely collected data of patients who underwent any kind of elective cardiac surgery in our university cardiovascular centre between 07.01.2018 and 30.06.2020. The database contains descriptive parameters, history of past illnesses, recent medication. The investigators record the type of surgery, the list of contributory physicians, the length of the surgery and the data of the anaesthesiological report. After the surgery the researchers want to record the postoperative parameters on the ICU ( infusion - fluid balance, blood transfusion, bleeding, main hemodynamic parameters, length of mechanical ventilation,main parameters of arterial blood gas analysis). Moreover th investigators want to collect psychosocial tests (Beck Depression Inventory, State Anxiety Scale, Trait Anxiety Scale and EQ-5D for the measurement of quality of life) to get more information from the postoperative condition of the patients.

Official Title
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Endocrine Changes in Adults Undergoing Cardiac Surgery

Conditions
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Psychology, Social, Endocrine System Diseases, Cardiac Surgery, Quality of Life

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: elective cardiac surgery Exclusion Criteria: lack of consent pregnancy acute surgery exposition with iodin-containing contrast material

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of hospital and intensive care unit stay | The correlation of the measured pre and postoperative endocrine profile and the length of intensive care unit stay | Participants will be followed for the duration of hospital stay, an expected average of 2 weeks. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The composite of in-hospital death from any cause. | Any cause of death in current group | Participants will be followed for the duration of hospital stay, an expected average of 12 weeks. | 
| Correlation between preoperative Beck Depression Inventory and the length of hospital stay | The effect of psychological state of the length of hospital stay | Participants will be followed for the duration of hospital stay, an expected average of 12 weeks. | 
| Correlation between preoperative State Anxiety Scale and the length of hospital stay | The effect of psychological state of the length of hospital stay | Participants will be followed for the duration of hospital stay, an expected average of 12 weeks. | 
| Correlation between preoperative Trait Anxiety Scale and the length of hospital stay | The effect of psychological state of the length of hospital stay | Participants will be followed for the duration of hospital stay, an expected average of 12 weeks. | 
| Correlation between preoperative EQ-5D inventory and the length of total hospital stay | Correlation between the preoperative quality of life state and the hospital stay | Participants will be followed for the duration of hospital stay, an expected average of 12 weeks. |