Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to use the MURDOCK Horizon 1.5 infrastructure (Duke Instutional Review Board Pro00011196) to specifically target and enroll 1,000 participants across age groups and other demographic categories in order to develop a diverse cohort with specific physical and cognitive performance data paired with biological samples.

Detailed Description
-----------------
The MURDOCK Study, proposes this Horizon 2 study to collect a brief physical and cognitive performance assessment from 1,000 MURDOCK Registry participants. Blood sample aliquots will also be obtained. These physical and cognitive performance data, paired with -omics data from plasma and serum sample analyses, offer promise in the discovery of biomarkers for functional decline. This research will provide an important basis for our understanding of the physical, lifestyle, and genetic factors which, over the lifespan, contribute to changes in physical and cognitive capabilities as we age.

Official Title
-----------------
Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository

Conditions
-----------------
Aging, Physical Functioning, Cognitive Functioning, Fitness

Intervention / Treatment
-----------------
* Genetic: Biomarker studies


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: A resident of Cabarrus County and/or the city of Kannapolis (and surrounding regions) or certain portions of Rowan, Mecklenburg, or Stanly counties in North Carolina for 6 or more months of the year. Age 30 or older Exclusion Criteria: Female that is currently pregnant Having had a heart attack, angina, congestive heart failure, or fluid in the lungs within the past 6 months Participant that requires consent by a legally authorized representative Participant that cannot walk 30ft without human assistance

Ages Eligible for Study
-----------------
Minimum Age: 30 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Community, Physical Performance<br> | Genetic: Biomarker studies<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository | Factors associated with physical function and physical activity and change in physical activity and function over two-year follow-up. | Upto 2 years or 24 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Aging, Healthy Aging, Physical Performance, Physical Functioning, Cognitive Functioning, Fitness, Physical Activity