Body Responses to Bean Physical Form and Beano

Study Overview
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Brief Summary
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The aim of this study is to determine the effects of bean physical form (whole versus blended) and Beano on postprandial responses. The postprandial responses the investigators will examine include blood glucose, appetite, metabolic rate, physical symptoms, and mood. To accomplish this aim the investigators will conduct a randomized, placebo-controlled trial in overweight and obese but otherwise healthy (non-diabetic) men and women

Official Title
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Effects of Bean Form and Digestive Enzyme Availability on Postprandial Responses

Conditions
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Appetite and Glucose Responses

Intervention / Treatment
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* Other: blended lentils
* Other: whole lentils
* Other: no lentils


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged 18-55 years old Body mass index (BMI) 18.5-40 kg/m2 Generally healthy A non-smoker Any ethnicity Free of chronic diseases and not taking medications or dietary supplements known to affect energy regulation or appetite Exclusion Criteria: Beano drug label warnings including galactosemia, severe liver or kidney disease, allergies or sensitivities to any of the ingredients in Beano Peri and postmenopausal women Pregnant or lactating women (currently and within the past 1 year) Currently dieting or consuming unusual or a medically prescribed diet Net weight loss or gain (>5 lbs) within the last six months Consuming 1/2c per day or more of legumes, not including peanuts Having taken Beano any time in the past 3 months Extreme problems digesting beans Fasting glucose >126 mg/dl Blood pressure >140/90 mmHg Moderate intensity or higher intensity exercise > 6 h/wk Predicted energy requirement < 2000 kcal/d or >4000 kcal/d

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: alpha-gal & blended lentils<br>3 capsules of alpha-gal taken with blended lentils | Other: blended lentils<br>* blended lentils burritto breakfast<br>|
| Experimental: alpha-gal & whole lentils<br>3 calpsules of alpha-gal taken with whole lentils | Other: whole lentils<br>* whole lentils breakfast burritto<br>|
| Experimental: alpha-gal & no lentils<br>3 capsules of alpha-gal taken with no lentils control | Other: no lentils<br>* No lentils control breakfast burritto<br>|
| Placebo Comparator: Placebo & blended lentils<br>3 capsules of placebo taken with blended lentils | Other: blended lentils<br>* blended lentils burritto breakfast<br>|
| Placebo Comparator: Placebo & whole lentils<br>3 capsules of placebo taken with whole lentils | Other: whole lentils<br>* whole lentils breakfast burritto<br>|
| Placebo Comparator: Placebo & no lentils<br>3 capsules of placebo taken with no lentils control | Other: no lentils<br>* No lentils control breakfast burritto<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Appetite | Subjects were given an appetite questionnaire to complete at time 0, 20, 40, 60, 120 and 180 | 3 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood glucose | Finger prick blood were taken at time 0, 20, 40, 60, 120 and 180 for glucose measurement using a glucometer | 3 hours | 
| fasting and postprandial energy expentidure | Fasting energy expenditure was measured for thirty minutes before meal and beano intervensions were given and at postprandial time points 20, 40, 60, 120 and 180, postprandial energy expenditure was measured for 15 minutes at each time point | 4 hours | 
| gastrointestinal symptoms | At timepoints 0, 20, 40, 60, 120 and 180, gastroinstinal symptoms were assessed using a questionnaire | 3 hours |