Impact of Resveratrol on Brain Function and Structure

Study Overview
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Brief Summary
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The study will investigate whether resveratrol could provide positive effects on memory and brain structures and functions in healthy elderly participants.

Detailed Description
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Cell and animal studies postulated various beneficial effects of resveratrol, ranging from a reduction of inflammatory processes and the treatment of cancer to the prevention of cardiovascular diseases and stroke. With regard to cognitive decline, rodent models for Alzheimer's disease (AD) showed improved learning and decelerated hippocampal neurodegeneration after intake of resveratrol. Animal and first human studies provided evidence that resveratrol might serve as an easy, cost-effective option to develop novel prevention and treatment strategies against age-associated cognitive decline. To test this hypothesis, the researchers study general brain structure and function on healthy older individuals (> 60years old).

Official Title
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Impact of Resveratrol on Brain Function and Structure

Conditions
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Healthy

Intervention / Treatment
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* Dietary Supplement: resveratrol supplementation
* Dietary Supplement: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: subjects who are healthy or with subjective memory complaints older than 60 years old normal to overweight participants (BMI: 22-40 kg/sqm) Exclusion Criteria: dementia Psychiatric diseases severe untreated internal diseases diabetes younger than 60 years BMI < 22 or >40

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: resveratrol supplementation<br>Dietary Supplement: Resveratrol | Dietary Supplement: resveratrol supplementation<br>* 6 months of resveratrol supplementation<br>|
| Placebo Comparator: placebo supplementation<br>Dietary Supplement: Placebo | Dietary Supplement: Placebo<br>* 6 months of placebo intake<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline Verbal Learning Task Scores at 6 months |  | Baseline (timepoint 0), after 6 months (timepoint 6 months) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline Verbal Learning Task Scores at 12 months |  | after 12 months (timepoint 12 months) | 
| Mini Mental State Examination |  | Baseline (timepoint 0), after 6 months (timepoint 6 months) and after 12 months (timepoint 12 months) | 
| Structural changes on the brain MRI images |  | Baseline (timepoint 0), after 6 months (timepoint 6 months) and after 12 months (timepoint 12 months) | 
| Functional changes on the brain MRI images |  | Baseline (timepoint 0), after 6 months (timepoint 6 months) and after 12 months (timepoint 12 months) | 
| Plasma biomarkers |  | Baseline (timepoint 0), after 6 months (timepoint 6 months) and after 12 months (timepoint 12 months) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Memory, Resveratrol, elderly, cognition