ER2 Frailty Levels and Incident Adverse Health Events in Older Community Dwellers

Study Overview
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Brief Summary
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Older adults' health and functional status are heterogeneous because of the various cumulative effects of chronic diseases and physiologic decline, contributing to a vicious cycle of increased frailty 1-4. Thanks to advances in medicine and hygiene, a growing number of older adults spend more years with a greater range of chronic diseases causing disability but not mortality 5. Health systems need to face this new challenge 4,5. Quantification of frailty and its association with the occurrence of incident adverse health events (i.e., functional decline, unplanned hospitalizations) is crucial to understand how health systems may efficiently respond to this situation 6. This study aims to examine the association of the ER2 tool score and its stratification in three levels for incident adverse health events in older community dwellers and to compare this association with three validity frailty indexes which are the Cardiovascular Health Study (CHS) frailty index, Study of Osteoporotic Fracture (SOF) index and Rockwood frailty index.

Official Title
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Association Between Emergency Room Evaluation and Recommendations Tool (ER2) Frailty Levels and Incident Adverse Health Events in Older Community Dwellers: Results of the NuAge Study

Conditions
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Frailty, Emergencies, Aging

Intervention / Treatment
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* Other: No intervention: secondary use of a database


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All enrolled participants of NuAge Study who agreed to be part of the NuAge Database and Biobank for future research purposes Exclusion Criteria: Missing data Participants' refusal to use their data for a purpose not identified during their recruitment.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| NuAge participants<br>All Individuals of the NuAge study who agreed to be part of the NuAge Database for future research purposes | Other: No intervention: secondary use of a database<br>* Statistical analyses<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ER2 | 6-item questionnaire determining a stratification of frailty risk in three levels (Low, moderate, high) | 4 years | 
| SOF index | index with 3 items determining a level of frailty from 0 (patient is vigorous) to 1 (patient is pre-frail) | 4 years | 
| CHS index | index with 5 items determining a level of frailty from 0 component positive (patient is vigorous), 1 or 2 positive components (patient is in an intermediate stage) to 3 or more positive components (patients is frail) | 4 years | 
| Rockwood index | index determining a level of frailty from 0 to 17 (less than 5: patient is vigorous, between 6 and 11 patient is apparently vulnerable and above 12 patient is in severe frailty) | 4 years | 
| Physical functional decline | annual variation of physical functional score available in the Nuage database | 4 years | 
| Falls | presence or absence of falls, information available in the Nuage database | 4 years | 
| Hospitalizations | presence or absence of hospitalizations, information available in the Nuage database | 4 years | 
| Mortality | death of the participant, information available in the Nuage database | 4 years |