Genetics of Latent Autoimmune Diabetes in Adults

Study Overview
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Brief Summary
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This is a prospective study that will study adults and has the objective of examining 'Latent Autoimmune Diabetes in Adults' (LADA) to understand how this trait is influenced by genetic factors.

Detailed Description
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A case-control study approach will be used to compare the allelic frequencies of Deoxyribonucleic acid (DNA) markers of the cases (i.e., LADA patients) to a randomly selected control samples that does not have the trait under study. To study the role of genetic factors in LADA, the study seeks to determine if certain genomic regions that are captured or mirrored by selective Single nucleotide polymorphisms (SNPs) that are genotyped, are over or underrepresented in those with the disease compared to those who do not. The level of auto-antibodies is the serum can also be studied as a quantitative trait where we ask the question if there is correlation with specific SNP alleles that are genotyped. The markers that are found to be over or under-represented in the study cases will then be tested in an independent set of patients also recruited in this study. This allows us to filter markers that show significance simply by chance and prevents us from being misled.

Official Title
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A Study of the Genetic Causes of Latent Autoimmune Diabetes in Adults

Conditions
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Latent Autoimmune Diabetes in Adult

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosed type 2 Diabetes (T2D) patient with: BMI <30 at diagnosis; Age >25-<50 at diagnosis OR Diagnosed type 1 Diabetes (T1D) patient with: Age >25 at diagnosis OR - Currently Diagnosed with LADA with age at initial diagnosis of Diabetes >25 years and a positive GAD65 antibody test Exclusion Criteria: Any underlying disease or condition that is a contraindication for obtaining 18.0 ml of blood. Inability to obtain an informed consent from a given LADA case. Blood sampling has already occurred for a given subject. Previous GAD65 antibody test(s) negative.

Ages Eligible for Study
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Minimum Age: 25 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Latent Autoimmune Diabetes in Adult<br>Individuals who meet criteria for Latent Autoimmune Diabetes in Adult | |
| Without Latent Autoimmune Diabetes in Adult<br>Individuals who do not meet criteria for Latent Autoimmune Diabetes in Adult | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Identify variations in the human genome associated with LADA by genotyping cases and comparing allele frequencies to an existing control database |  | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Identify associations between genetic variants with certain measurable risk profiles that can be used to judge the health status or well being of a LADA case. |  | 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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LADA, Latent Autoimmune Diabetes in Adults, Latent Autoimmune Diabetes, Latent Diabetes in Adults