Effects on Respiratory Patterns and Patient-ventilator Synchrony Using Pressure Support Ventilation

Study Overview
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Brief Summary
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Pressure Support Ventilation use Expiratory triggering sensitivity(Esense) to transfer inspiration to expiration,the value of Esense is fixed.That may lead to asynchrony between humans and ventilators,making people uncomfortable and prolonging weaning time.Some ventilators have auto cycle function Based on curves of pressure on respiratory patterns,it will make the transforming more synchrony with humans.Our prospective observational study will prove the superiority of the auto cycle function.

Detailed Description
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From August 31st 2016 to August 31st 2017, all ARDS 、COPD and postoperative patients admitted to the ICUs will be enrolled. The demographic characteristics, diagnosis, formerly medical history, Ventilator indications, Ventilator data, other respiratory treatments, weaning outcome and 28 day mortality will be recorded

Official Title
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Effects on Respiratory Patterns and Patient-ventilator Synchrony in Different Ventilator Using Pressure Support Ventilation

Conditions
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Acute Respiratory Distress Syndrome, COPD, Post Operative

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ARDS,COPD and Postoperative patient Exclusion Criteria: variety of reasons can not be placed next to the bed by the nasal EAdi catheter

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| E5 Esense 10%<br>PSV mode using E5 ventilator with Esense 10% | |
| E5 Esense 30%<br>PSV mode using E5 ventilator with Esense 30% | |
| E5 Esense 50%<br>PSV mode using E5 ventilator with Esense 50% | |
| Servo-I Esense 10%<br>PSV mode using Servo-I ventilator with Esense 10% | |
| Servo-I Esense 30%<br>PSV mode using Servo-I ventilator with Esense 30% | |
| Servo-I Esense 50%<br>PSV mode using Servo-I ventilator with Esense 50% | |
| E5 Esense autocycle<br>PSV mode using E5 ventilator with Esense Auto cycle | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| patient-ventilator synchrony using PSV mode between different ventilator for 180mins |  | 180mins after the patients involved | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient Respiratory Patterns during Pressure Support Ventilation for 180mins |  | 180mins | 
| Patient gas exchange during Pressure Support Ventilation for 180mins |  | 180mins | 
| Effects on Respiratory Patterns in different Expiratory triggering sensitivity for 180mins |  | 180mins | 
| work of triggering and respiratory in different Expiratory triggering sensitivity for 180mins |  | 180mins | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Synchrony, Pressure Support Ventilation