linjc16/ctgov huggingface dataset:
Use of Jumping Mechanography as a Method to Assess Musculoskeletal Status in Older Adults

Study Overview
=================
Brief Summary
-----------------
Decline in muscle function may increase risk of hip fracture and decrease quality of life. Different tests are currently used to measure muscle function but they do not work for all individuals. A test called jumping mechanography, which measures jumping power, may be useful in more people and obtain better information. This study will help us determine whether this test is able to detect differences between muscle function in younger and older adults, as well as whether it is a safe method to use in all ages.

Official Title
-----------------
Use of Jumping Mechanography as a Method to Assess Musculoskeletal Status in Older Adults: A Pilot Study

Conditions
-----------------
Musculoskeletal Status, Muscle Weakness

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Women and men aged 20 to 30 or ≥ 60 years Able and willing to sign informed consent. Ability to stand without assistance. Exclusion Criteria: Acute pain different and/or worse than the individuals chronic baseline pain History of recent trauma to musculoskeletal system Neuromuscular disease impairing balance to the degree of not being able to stand without assistance. History of fragility fracture within the last year Patients with a BMD T-score of less than -3.5 at any measured site and a vertebral fracture. History of severe end-organ disease, e.g., cardiovascular, hepatic, hematologic, pulmonary, etc., which might limit the ability to complete this study. Recent history of malignancy with metastasis to the musculoskeletal system.

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Men and women 60 years and older | |
| 2<br>Men and women 20-30 years of age | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The primary outcome is the instantaneous weight corrected peak power taken from the maximal countermovement jump |  | single session |
Treatment of BV With Donaxyl and a Molecular Test of Cure

Study Overview
=================
Brief Summary
-----------------
. Treatment with dequalinium chloride vaginal tablets for 6 days had a cure rate lower than expected; only 37% of patients were considered cured one month after treatment.

Detailed Description
-----------------
This is the first study to utilize a molecular diagnostic test as a test of cure for bacterial vaginosis. The Nugent score is a reliable method for diagnosing bacterial vaginosis, but similar to traditional clinical diagnostic methods, it is not equally reliable when utilized as a test of cure. This study demonstrated that molecular diagnostic testing can be used as a test of cure and this is the first molecular test that can do that. Treatment with dequalinium chloride vaginal tablets for 6 days had a cure rate lower than expected; only 37% of patients were considered cured one month after treatment.

Official Title
-----------------
Treatment of Bacterial Vaginosis With Dequalinium Chloride Vaginal Tablets and a Test of Cure Using a New Molecular Diagnostic Test for the Diagnosis of Bacterial Vaginosis

Conditions
-----------------
Bacterial Vaginoses

Intervention / Treatment
-----------------
* Drug: D


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: BV Exclusion Criteria: No other infection (Gc, clhlamydia, trihomonas)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: D|treatment of BV with dequalinium chloride vaginal tablets|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cure rate of BV | how many that are cured of BV after 1 month | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnosis of BV using molecular test | the Kappa index Hay/ison diagnosis and the molecular test | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Bacterial vaginosis, polymerase chain reaction, molecular diagnostic
Evaluation of Antral Ultrasonography for Full Stomach Diagnosis Before Pediatric Surgical Emergencies

Study Overview
=================
Brief Summary
-----------------
This study evaluates antral ultrasonography for the diagnosis of full stomach before surgical emergencies in pediatric population. Preoperative ultrasonographic antral evaluation is compared to peroperative gastric aspirate with nasogastric tube.

Conditions
-----------------
Gastric Content, Full Stomach Status

Intervention / Treatment
-----------------
* Procedure: Preoperative gastric ultrasonography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Surgical emergency procedure ASA I-II Exclusion Criteria: Ultrasound antrum assessment not possible No nasogastric tube during surgery Vital emergency Patient from Critical Care Ward Time between ultrasound assessment and gastric content collecting up to 20min Child and/or Parents doesn't/don't want to participate in the study Personal medical history of gastric or oesophagus desease

Ages Eligible for Study
-----------------
Minimum Age: 3 Years
Maximum Age: 15 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Preoperative gastric ultrasonography<br> | Procedure: Preoperative gastric ultrasonography<br>* Before surgical emergency procedure, a preoperative antral ultrasonography is performed to assess gastric content.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Volume of gastric content aspirated throw nasogastric tube |  | 20 min | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Grades as described by Perlas et al. for ultrasonographic qualitative evaluation of gastric content |  | 20 min | 
| relationship between peroperative gastric content and ultrasonographic antrum assessment |  | 20 min | 
| Time to perform antral ultrasonography |  | 20 min | 
| Quality of image obtained during antral ultrasonography |  | 20 min | 
| Child behaviour during antral ultrasonography |  | 20 min | 
| Number of participants with exploitable antral ultrasonography |  | 20 min | 
| Reasons for antral ultrasonography failure |  | 20 min | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
ultrasonography, aspiration, emergency, children, antrum
Role of Lung Ultrasound in Weaning From Mechanical Ventilation in Postoperative Neurosurgical ICU Patients

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to demonstrate the role of lung ultrasound in weaning from mechanical ventilation in neurosurgical ICU patients compared to the ordinary tools as chest X-ray , ABG, rapid shallow breathing index, ventilator parameters.

Official Title
-----------------
Role of Lung Ultrasound in Weaning From Mechanical Ventilation in Postoperative Neurosurgical ICU Patients :Prospective , Randomized Double-blinded Study

Conditions
-----------------
Intensive Care (ICU)

Intervention / Treatment
-----------------
* Device: lung ultrasound
* Other: routine tools


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Mechanically ventilated patients ASAI ,ASAII, ASAIII Exclusion Criteria: Patients or gurdians refuse Patients with pneumthorax Patients with pleural effusion Patients with surgical emphysema Glasco coma score more than 8 Patients on high inotropic support patients with diaphragmatic paralysis

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: lung ultrasound<br> | Device: lung ultrasound<br>* bedside lung ultrasound will be done for patients<br>Other: routine tools<br>* chest X-ray , ABG, RSBI, Ventilator parameters will be done for all patients<br>|
| Active Comparator: x-ray, ABG, RSBI, Vetilator parameters<br> | Other: routine tools<br>* chest X-ray , ABG, RSBI, Ventilator parameters will be done for all patients<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| success of weaning | trans-thoracic lung ultrasound will be done to patients to start weaning | success of weaning for 48 hours |
NB1011 Administered by Continuous Infusion in Cancers That Overexpress Thymidylate Synthase (TS)

Study Overview
=================
Brief Summary
-----------------
The purpose of this trial is to assess the tolerability and safety of NB1011 in the treatment of patients with cancers that overexpress TS, such as ovarian, gastrointestinal, colorectal, bladder, breast, and lung cancers.

Official Title
-----------------
A Phase I/II Study of NB1011 Administered Intravenously by Continuous Infusion in an Every Second Week Regimen With Open-label Continuation in Cancers That Overexpress the Enzyme Thymidylate Synthase

Conditions
-----------------
Tumors

Intervention / Treatment
-----------------
* Drug: NB1011


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Advanced, recurrent, or metastatic solid tumors TS overexpression (> 4 by reverse transcription polymerase chain reaction [RT-PCR]) in archival and fresh samples Suitable for experimental monotherapy Measurable disease Exclusion Criteria: Tumors that cannot be biopsied or with low level of TS expression Requirement for concomitant anticancer therapy Treatment with another investigational product within 30 days of study entry Pregnant or lactating women Active or uncontrolled serious bacterial, viral, fungal, or parasitic infection. HIV infection Clinically apparent meningeal or central nervous system (CNS) metastases or carcinomatous meningitis

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: NB1011|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Safety/tolerability of NB1011 infusions |  |  | 
| Determination of maximum tolerated dose (MTD) |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pharmacokinetics of NB1011 and its metabolite |  |  | 
| Clinical activity as per Response Evaluation Criteria in Solid Tumors (RECIST) criteria |  |  | 
| Assessment of TS overexpression |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
colorectal cancer, ovarian cancer, lung cancer, breast cancer, small bowel cancer, Advanced, recurrent, or metastatic solid tumors of any type, TS overexpression confirmed by fresh biopsy (RTPCR), Suitable for experimental monotherapy
Participant Satisfaction With Two Different Summative Assessment Methods - a Mixed Method Questionnaire Study

Study Overview
=================
Brief Summary
-----------------
Participants of Immediate Life Support and Advanced Life Support Courses, where two different summative assessment methods were used are asked about their satisfaction with the assessment method using a questionnaire. Both quantitative questions using an 11-point-Likert scale as well as open-ended qualitative questions will be asked. The primary aim of this study is to find out which variant of summative assessment is perceived by course participants as testing their leadership competency best, immediately after the comparison as well as 1 year later to identify any long-term effects on the students.

Official Title
-----------------
Participant Satisfaction With Two Different Summative Assessment Methods - a Mixed Method Questionnaire Study

Conditions
-----------------
Assessment Evaluation

Intervention / Treatment
-----------------
* Other: different assessments


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All 5th and 6th year medical students at the University of Bern, Switzerland, study year 2017/2018 and 2018/2019 Exclusion Criteria: Refusal to participate
Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| ERC<br>all students assessed by the methods used by the European Resuscitation Council | Other: different assessments<br>* coded survey about NTS and assessment<br>|
| AHA<br>all students assessed by the methods used by the American Heart Association | Other: different assessments<br>* coded survey about NTS and assessment<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Participant satisfaction with summative assessment methods during Life Support Courses | evaluation of NTS assessed by assessment | directly after assessment and 1 year later |
Descriptive and Risk Factors Analysis of All-cause Postoperative Death in Patients Undergoing Emergency Surgery

Study Overview
=================
Brief Summary
-----------------
The investigators are aimed to develop and externally validate a prediction model of clinical risk factors that quantifies postoperative death after emergency surgery. The investigators identify all patients treated with emergency surgery, between 2000 and 2020, within the Wuhan Union hospital and all collaborators. The surgical patient cohort will be matched with the National Death database to determine the patient's postoperative death data. 60% patients were randomly selected to the development cohort. Logistic regression analysis for prediction of postoperative death adjusted for different covariates. The model was externally validated in the remaining 40% patients.

Official Title
-----------------
Descriptive and Risk Factors Analysis of All-cause Postoperative Death in Patients Undergoing Emergency Surgery

Conditions
-----------------
Postoperative Death

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients Undergoing Emergency Surgery Exclusion Criteria: Patients with incomplete electronic medical record information
Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative Death |  | The mortality within 5 years after the emergency surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Postoperative death, Emergency surgery, Prediction model
Comperative Trial Between an Accommodative Iol and Monofocal Iol

Study Overview
=================
Brief Summary
-----------------
a comparison of two intraocular lenses in regard of accommodative power.

Detailed Description
-----------------
A new accommodating IOL (Acuity Ltd, Israel) will be compared with Alcon's Acrysof for 1 year for visual acuity and distance and near best corrected visual acuity.

Official Title
-----------------
A Randomized Single Blind Comparative Study of the Acuity's C-Well Accommodating Intra Occular Lens (AIOL) Against Alcon's Acrysof

Conditions
-----------------
CATARACT SURGERY

Intervention / Treatment
-----------------
* Device: Acrysof
* Device: Acuity's AIOL


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age between 30 and 65 Required cataract operation in one or both eyes BCVA potetial at least 20/30 Clear intraoccular media Willing to participate in study as evidenced by signing a written Informed Consent Exclusion Criteria:Main Prior surgery at the selected eye No light perception or poor potential for improvement Phacodonesis and damaged zonules Pupil size at least 6 mm. History of uveitis Macular disease decreasing vision below 20/30 Amblyopia Axial length shorter than 21 mm and longer than 25 mm

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Acrysof<br>Routine monofocal IOL | Device: Acrysof<br>* Monofocal IOL<br>|
| Active Comparator: Acuity's AIOL<br>Accomodaing IOL | Device: Acuity's AIOL<br>* Accommodating IOL<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| distance and near visual acuity |  | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| centration pco |  | 1 year |
Obesity and Metabolic Surgery in Patients With Type I Diabetes

Study Overview
=================
Brief Summary
-----------------
Obesity is the indication for bariatric surgery in type I diabetes. Interestingly postsurgery the patients improve remarkable in their need for insulin, not only in the daily total insulin dosage but also in the dosage of IU per kg.

Detailed Description
-----------------
The investigators performed a retrospective analysis on 16 patients undergoing weight loss surgery in obesity with concomitant type I diabetes. All patients were evaluated during Follow - Up to analyze insulin dosage and metabolic changes.

Official Title
-----------------
Obesity and Metabolic Surgery in Patients With Type I Diabetes

Conditions
-----------------
Type I Diabetes

Intervention / Treatment
-----------------
* Other: Obese patients with type I diabetes


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: type I diabetes BMI > 40kg/m2 Exclusion Criteria: type II diabetes

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Obese patients with type I diabetes|Postsurgical follow - up in obese patients with type I diabetes|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Insulin dosage | Insulin dosage postsurgery | up to 8 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Excess Weight loss in % |  | up to 8 years | 
| Change in HgA1c |  | up to 8 years | 
| Change in lipids |  | up to 8 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
obesity surgery, type I diabetes, weight loss, insulin dosage, postsurgery metabolic changes
A Pilot Study Involving an Asthma Management Program for Inner-city Early Head Start Children

Study Overview
=================
Brief Summary
-----------------
The Early Head Start program serves lower socioeconomic inner-city children from birth to 3 years. This population has a higher incidence of asthma due to increased exposures. The primary objective of this study is: To evaluate the effect of early identification of these high risk, inner-city asthmatic infants, age 1-3 years, and early treatment with pulmicort respules on asthma morbidity (asthma symptoms and use of rescue medications), infant pulmonary functions, and use of health care resources (unscheduled clinic visits, emergency room visits and hospitalizations). To obtain pilot behavior information using Carey Temperament Scale, Bitsea and expand to Itsea if indicated.

Official Title
-----------------
A Pilot Study Involving an Asthma Management Program for Inner-city Early Head Start Children

Conditions
-----------------
Asthma

Intervention / Treatment
-----------------
* Drug: Budesonide respules


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children 12-36 months of age with a history of wheezing or airway reactivity responding to bronchodilators, or diagnosed with asthma by a physician. Exclusion Criteria: Children less than 12 months or greater than 36 months of age. Children diagnosed with attention deficit disorder by a physician or psychologist.

Ages Eligible for Study
-----------------
Minimum Age: 12 Months
Maximum Age: 36 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Budesonide respules|Budesonide respules 0.5 mg nebulized once a day for 4 months of the study.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| FEV0.5 |  | 2 months and 6 months into study | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| emergency room visits |  | number of visits from baseline to 2 months and 2 months to 6months of study | 
| behavior scores |  | measured at baseline, 2 months and 6 months | 
| number of asthma exacerbations from baseline to 2 months and 2 months to 6 months |  | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Asthma, Children