linjc16/ctgov huggingface dataset:
Does Pregnancy Increase Risk of Ventral Hernia Recurrence?

Study Overview
=================
Brief Summary
-----------------
The investigators will examine if pregnancy increases risk of ventral hernia recurrence

Detailed Description
-----------------
The investigators will establish a cohort of female fertile patients who underwent ventral hernia repair (Umbilical, Epigastric and Incisional hernia repair) registered in the Danish Hernia Database. The investigators will link these data at an individual level with the Danish National Patient Registry (DNPR), Danish Medical Birth Registry (DMBR) and the Danish Civil Registry (CPR). From DMBR, subsequent pregnancies in the study cohort will be noted. From DNPR, ventral hernia recurrence, defined as clinical recurrence and/or reoperation for recurrence will be noted. Cases registered with both clinical recurrence and reoperation for recurrence, the date of the earliest registration will be defined as the date of ventral hernia recurrence. From CPR, date of death or emigration will be noted. Through an extended Cox regression analysis, handling pregnancy as a time-dependent variable, the investigators will examine whether pregnancy is associated with an increased risk of ventral hernia recurrence.

Official Title
-----------------
Does Pregnancy Increase Risk of Ventral Hernia Recurrence?

Conditions
-----------------
Recurrent Hernia of Anterior Abdominal Wall

Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: Fertile female patient Exclusion Criteria: non-Danish citizen

Ages Eligible for Study
-----------------
Minimum Age: 12 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical Ventral Hernia (Epigastric, Umbilical and Incisional Hernia) Recurrence | Clinical ventral hernia recurrence will be defined as clinical recurrence retrieved from the Danish National Patient Registry. | 0-7 years | 
| Ventral Hernia (Epigastric, Umbilical and Incisional Hernia) Recurrence Repair | Ventral hernia recurrence repair will be defined as reoperation retrieved from the Danish National Patient Registry. | 0-8 years |
Randomized Control Study of Dermal Staples vs Subcuticular Sutures on Postoperative Scar After Thyroidectomy

Study Overview
=================
Brief Summary
-----------------
In this study, a randomized controlled study was conducted between two groups of 20 classic recipients of intradermal sutures and 20 recipients of intradermal staple methods for patients undergoing the same cervical incision. This is a study to see if there is any difference in pain and esthetics in scar formation of these groups.

Official Title
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Randomized Control Study of Dermal Staples vs Subcuticular Sutures on Postoperative Scar After Thyroidectomy

Conditions
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Thyroidectomy, Pain, Esthetic, Dermal Stapler

Intervention / Treatment
-----------------
* Device: INSORB
* Procedure: classic intradermal suture


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient who will have thyroid surgery Exclusion Criteria: done thyroid surgery before done any radiotherapy on neck who needs neck dissection laparoscopic ot robotic surgery under 18 years old or over 70 years old bad general condition, high American Society of Anesthesiologists (ASA) score (over 3) who used immunosuppressive drugs in 6 months breast feeder or pregnancy who disagrees to do this trial

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: dermal stapler<br> | Device: INSORB<br>* dermal stapler for skin closure<br>|
| Active Comparator: classic intradermal suture<br> | Procedure: classic intradermal suture<br>* intradermal suture for skin closure<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Modified Stony Brook Scar Evaluation Scale (SBES) | Evaluate scar | Change from Baseline scar at 6 months | 
| Manchester Scar Scale (MSS) | Evaluate scar | Change from Baseline scar at 6 months | 
| Visual Analogue Scale (VAS) | Evaluate pain | Change from Baseline pain at 6 months |
Pattern of Upper Gastrointestinal Lesions in Upper Egypt : Clinical, Endoscopic and Pathological Evaluation

Study Overview
=================
Brief Summary
-----------------
Upper Gastrointestinal (UGI) symptoms are among the commonest complaints for which patients seek medical attention, with the annual prevalence of dyspepsia approximating 25% . Endoscopy holds an important place in the diagnosis of UGI conditions by enabling visualization, photography, ultrasonography, and biopsying of suspicious lesions . It gives a better diagnostic yield over radiology particularly in the investigation of upper gastrointestinal bleeding, inflammatory conditions of the upper gastro-intestinal track like esophagitis, gastritis and duodenitis as well as the diagnosis of Mallory Weiss tears and vascular malformations .Dyspepsia in the absence of any other symptom was the indication for UGIE in the vast majority of patients. Close to 80% of our patients presented with dyspepsia not associated with any other symptom and in 50% of the patients the endoscopic findings were normal [4]. Other common reasons for UGIE were GERD symptoms, recurrent vomiting, dyspepsia associated with weight loss and patients with symptoms of UGI bleeding . Gastritis was the most frequent endoscopic finding in our patients, followed by duodenitis .Gastric ulcer was diagnosed more frequently than duodenal ulcers . Taking a biopsy is very helpful in diagnosis in our study. H. pylori colonization of the gut is the main cause of chronic gastritis and the principal etiological agent of gastric cancer and peptic ulcer disease . Gastric cancer was diagnosed, by endoscopy, about eight times more frequently in patients presenting with an alarm symptom like recurrent vomiting, dyspepsia together with weight loss or UGI bleeding .

Official Title
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Pattern of Upper Gastrointestinal Lesions in Upper Egypt : Clinical, Endoscopic and Pathological Evaluation

Conditions
-----------------
Pattern of Upper Gastrointestinal Lesions

Intervention / Treatment
-----------------
* Procedure: Endoscopy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - All patient undergoing elective and urgent upper GIT endoscopy either therapeutic or diagnostic. Exclusion Criteria: Patient undergoing endoscopic intervention for previously detected endoscopic lesion
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Endoscopy|Diagnostic upper Git endoscopy|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pattern of upper gastrointestinal lesions | We will see what common GIT lesions happen in patients of upper Egypt | 1 year |
Bone Structure and Strength Evaluated by Extreme-CT Scan Before and After Treatment of Hyper- and Hypothyroidism

Study Overview
=================
Brief Summary
-----------------
The aim to evaluate the bone structure by Dexa-scan, extreme CT and bone markers before and one year after treatment for a thyroid functional disorder

Detailed Description
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The aim to evaluate the bone structure by Dexa-scan, extreme CT and bone markers before and one year after treatment for a thyroid functional disorder. Women with hyper- og hypothyroidism are included and undergo usual treatment. Patients are stratified into 10 different groups.

Official Title
-----------------
Bone Structure and Strength Evaluated by Extreme-CT Scan Before and After Treatment of Hyper- and Hypothyroidism

Conditions
-----------------
Hyperthyroidism, Hypothyroidism

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: informed consent, female sex, age 20-85 years, indication for treatment of the thyroid disorder, Exclusion Criteria: pregnancy, renal insufficiency, known osteoporosis, other disease that may affect bone metabolism, medication which affects bone metabolism, T-score below -3.5, thyroidea ophthalmopathy with indication for steroids,

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| hyperthyroidism<br>61 pre- and postmenopausal women with hyperthyroidism | |
| hypothyroidism<br>32 pre- and postmenopausal women with hypothyroidism | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Thyroid Extreme CT | Bone cortical thickness in the radius measured by high-resolution peripheral quantitative CT, in newly diagnosed thyroid disorder, before and after treatment aimed to obtain euthyroidism | one year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
osteoporosis, hyperthyroidism, hypothyroidism
Drug Interaction Study of Digoxin and BI 10773

Study Overview
=================
Brief Summary
-----------------
The objective of the study is to investigate the relative bioavailability of digoxin after concomitant multiple oral administration of BI 10773 and a single dose of digoxin in comparison to digoxin given alone to healthy male and female subjects.

Official Title
-----------------
Relative Bioavailability of a Single Oral Dose of Digoxin (0.5 mg) When Administered Alone or in Combination With Multiple Oral Doses of BI 10773 (25 mg qd) in Healthy Male and Female Volunteers (an Open-label, Randomised, Two-way Crossover Study)

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Drug: Digoxin plus BI 10773
* Drug: Digoxin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: -Healthy male and female subjects Exclusion criteria: -Any relevant deviation from healthy conditions

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Digoxin alone (Reference)<br>Tablet, oral administration with 240 mL water | Drug: Digoxin<br>* Digoxin 0.5 mg as single dose<br>|
| Experimental: Digoxin plus BI 10773 (Test)<br>Tablets, oral administration with 240 mL water | Drug: Digoxin plus BI 10773<br>* Digoxin 0.5 mg as single dose, BI 10773 medium dose once daily<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Digoxin: Area Under the Curve 0 to Infinity (AUC0-∞) | Area under the concentration-time curve of digoxin in plasma over the time interval from 0 extrapolated to infinity. | 1.5 hours (h) prior to the first dose and 20 minutes (min), 40 min, 1h, 1.5h, 2h, 2.5h, 3h, 4h, 6h, 8h, 10h, 12h, 24h, 48h, 72h, 96h after the first dose | 
| Digoxin: Maximum Measured Concentration (Cmax) | Maximum measured concentration of digoxin, per period. | 1.5 hours (h) prior to the first dose and 20 minutes (min), 40 min, 1h, 1.5h, 2h, 2.5h, 3h, 4h, 6h, 8h, 10h, 12h, 24h, 48h, 72h, 96h after the first dose | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Digoxin: Area Under the Curve 0 to Last Quantifiable Data Point (AUC0-tz) | Area under the concentration-time curve of digoxin in plasma over the time interval from 0 extrapolated to the time of the last quantifiable data point. | 1.5 hours (h) prior to the first dose and 20 minutes (min), 40 min, 1h, 1.5h, 2h, 2.5h, 3h, 4h, 6h, 8h, 10h, 12h, 24h, 48h, 72h, 96h after the first dose |
The Effects of Lumbar Stabilization Exercise on Transversus Abdominis Muscle Activation Capacity and Function in Chronic Low Back Pain Patients

Study Overview
=================
Brief Summary
-----------------
Purpose: The purpose of this study is to investigate the effects of lumbar stabilization exercises on pain intensity, transversus abdominis muscle (TrA) activation capacity, functional disability, and TrA thickness in patients with chronic low back pain (CLBP). Subjects: The subjects of this study were 30 CLBP patients. Methods: The experimental group performed diverse lumbar stabilization exercises in different postures, and the control group conducted an ordinary trunk muscle strengthening exercise. Results: There were significant differences in pain intensity, TrA activation capacity, functional disability, and TrA thickness between before and after the intervention in both groups. Significant differences between the two groups were shown in the pain intensity, TrA activation capacity, and functional disability after the intervention. However, there were no significant differences between the two groups in TrA thickness. Conclusion: Lumbar stabilization exercises in different postures could reduce pain, functional disability, and increase TrA activation capacity and thickness in CLBP patients.

Official Title
-----------------
Main Researcher for Effects of Lumbar Stabilization Exercise on Transversus Abdominis Muscle Activation Capacity and Function in Chronic Low Back Pain Patients

Conditions
-----------------
Low Back Pain

Intervention / Treatment
-----------------
* Other: lumbar stabilization exercise
* Other: trunk muscle strengthening exercise


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients who felt low back pain Exclusion Criteria: Orthopedic surgery within 6 months

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: lumbar stabilization exercises group<br>diverse lumbar stabilization exercises | Other: lumbar stabilization exercise<br>* lumbar stabilization exercise<br>|
| Other: trunk muscle strengthening exercise<br>trunk muscle strengthening exercise | Other: trunk muscle strengthening exercise<br>* trunk muscle strengthening exercise<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| transverse abdominis thickness | ultrasound image for measuring transverse abdominis thickness | 1 year |
Skin Sympathetic Nerve Activity and Cardiac Arrhythmia

Study Overview
=================
Brief Summary
-----------------
Sympathetic tone is important in cardiac arrhythmogenesis. The simultaneous recording of sympathetic nerve activity (SNA) and electrocardiogram (ECG) was obtained by invasive method. The purpose of this protocol is to further develop this recording method to turn it into a new non-invasive tool for arrhythmia prediction and detection. This method may also be useful in validating the results of surgical procedures aimed at sympathetic denervation

Official Title
-----------------
Skin Sympathetic Nerve Activity and Cardiac Arrhythmia

Conditions
-----------------
Sudden Death, Ventricular Tachycardia, Persistent Atrial Fibrillation

Intervention / Treatment
-----------------
* Device: SKNA recording


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - patient hospitalized at Bordeaux University Hospital for sudden death, ventricular tachycardia, persistent or paroxysmal atrial fibrillation treated by ablation and/or vein of Marshall ethanol infusion Exclusion Criteria: pregnancy, patient under 18 year old, patient with a cardiac stimulation device

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: SKNA group<br> | Device: SKNA recording<br>* The coupled recording of the sympathetic nervous activity of the skin and of an ECG will be carried out using the ME6000 device, CE marked, from the Bittium company. It will be performed for a maximum period of one hour at Day 1, Post-procedure between Day 1 and discharge from hospital, and month 6<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Delay between the discharge of the sympathetic system and the rhythmic event. | Temporal correlation of occurrence of sympathetic electrical event and cardiac arrhythmia by the MacNemar test will be performed. | Day 1 | 
| Delay between the discharge of the sympathetic system and the rhythmic event. | Temporal correlation of occurrence of sympathetic electrical event and cardiac arrhythmia by the MacNemar test will be performed. | Day 2 | 
| Delay between the discharge of the sympathetic system and the rhythmic event. | Temporal correlation of occurrence of sympathetic electrical event and cardiac arrhythmia by the MacNemar test will be performed. | Month 6 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Skin sympathetic nerve activity (SKNA), Electrocardiogram (ECG), Cardiac arrythmia
The VIDA After COVID Study

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to objectively identify and address social determinants of health (SDOH) priorities and barriers in Latino patients who survived or are vulnerable to COVID-19, and to understand the consequences of COVID-19 survivorship in local Latino communities.

Official Title
-----------------
Virtual Intervention and Direct Assessment (VIDA) of Social Determinants of Health in Southern Minnesota Latino Communities After Coronavirus Disease 2019 (COVID-19): A Pilot Study. The VIDA After COVID Study.

Conditions
-----------------
Covid19

Intervention / Treatment
-----------------
* Behavioral: Virtual Intervention Program


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Study population will be identified via community partnerships and peer referrals. Participants include Latino families in Southern Minnesota (Dover, Olmsted and Mower county, Minnesota) who survived COVID-19 after requiring ICU or hospital admission, and their families and/or their care partners, or Latino patients who are vulnerable to COVID-19, that have provided research authorization o identified via electronic health registries (following Institutional Review Board approved guidelines). Exclusion Criteria: Families that do not identify as Latino. Those living outside Dover, Olmsted and Mower County, Minnesota. Those that do not provide written consent.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Latino/Hispanic Virtual Intervention Program<br>Latino/Hispanic individuals will participate in culturally tailored virtual intervention program following a community-based collaborative design. | Behavioral: Virtual Intervention Program<br>* Four separate virtual individual and group interviews (via telephone or online), which will be scheduled with the help of champions and leaders of the Latino community who will collaborate as companions to improve the commitment and experience of families.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Social Determinants of Health (SDOH) Assessment Completed | Number of families in whom SDOH were assessed at baseline and follow-up interviews. | Through study completion, approximately 3 months |