Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome

Study Overview
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Brief Summary
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The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration. UA collapse does not occur during wakefulness, hence arousal-dependent compensation. Experimental inspiratory loading in normal subjects elicits respiratory-related cortical activity during wakefulness. The objective of this study is to test whether awake OSAS patients would exhibit a similar cortical activity. Whether or not such cortical compensatory mechanisms have cognitive consequences would be also analyze.

Official Title
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Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome, With and Without CPAP, During Wakefulness - Impact on Cognitive Functions

Conditions
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Obstructive Sleep Apnea Syndrome

Intervention / Treatment
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* Diagnostic Test: functional magnetic resonance imaging


Participation Criteria
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Eligibility Criteria
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Inclusion criteria : OSAS patients severe OSAS with an Apnea-Hypopnea Index (AHI) > 30/h without CPAP treatment Non-OSAS patients absence of OSAS (AHI < 15/h and absence of excessive daytime sleepiness with Epworth score <11) Non-inclusion criteria : < 18 years old >75 years old left-handed BMI> 40 kg/m² another sleep disorder central component of sleep apnea syndrome (central apnea index> 5 / h) current or past neurological pathology respiratory pathology (obstructive ventilatory disorder, restrictive ventilatory disorder, hypercapnia) MRI contraindication (metallic foreign body, claustrophobia, pregnant woman, etc.) taking drugs that can modify the BOLD signal on MRI (psychotropic drugs, vasodilators, vasoconstrictors, etc.), uncorrected sensory impairment (vision or hearing) protected by law. Exclusion criteria : pregnant woman according to the positive beta-hCG test result left-handed following the laterality questionnaire MINI results showing: a current mood episode a current disorder of the use of psychoactive substances or in the last 6 months (excluding tobacco) an eating disorder a diagnosis of bipolar disorder, current or past schizophrenia

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: non-OSAS patients<br>Patients without OSAS (Apnea-Hypopnea Index (AHI) < 15/h and absence of excessive daytime sleepiness with Epworth score <11) | Diagnostic Test: functional magnetic resonance imaging<br>* functional magnetic resonance imaging<br>|
| Experimental: OSAS patients<br>Patients with severe OSAS with an Apnea-Hypopnea Index (AHI) > 30/h | Diagnostic Test: functional magnetic resonance imaging<br>* functional magnetic resonance imaging<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Premotor cortex activation in OSAS patients without CPAP |  | Day 0 |