Built-in Calculator Optimizes Continuous Veno-venous Hemofiltration Prescription and Improves Therapeutic Quality in Critically-ill Acute Kidney Injury Patients

Study Overview
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Brief Summary
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The goal of this observational study is to compare in ICU patients received CVVH treatment. The main questions it aims to answer are: Control of Filtration fraction by built-in calculator Reduced filter clotting and prolong filter lifespan Improve patient mortality Participants will divided into before group and after group based on the day when built-in calculator for calculating Filtration fraction was utilized. Researchers will compare before group to see if there were differences in clotting events, filter downtime, filter lifespan, mortality, etc.

Detailed Description
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# built-in calculator for calculating Filtration fraction The calculator was built in prescription system since 2020/10/01 providing tempt filtration fraction for operators to adjust CVVH dose the protocol of patient care didn't change between before and after group.

Official Title
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Built-in Calculator Optimizes Continuous Veno-venous Hemofiltration Prescription and Improves Therapeutic Quality in Critically-ill Acute Kidney Injury Patients

Conditions
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CVVH, Filtration Fraction, Built-in Culculator

Intervention / Treatment
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* Device: Built-in calculator to calculate Filtration fraction


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ICU patients received CVVH during 2019 2021 (3 years) in our hospital Exclusion Criteria: under age of 20, pregnant, or with HIV infection

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Before group<br>Patient: ICU patients received CVVH between 2019/01/01 - 2020/10/01 (before utilization of built-in calculator) received regular protocol of ICU patient care (same in two groups) | |
| After group<br>Patient: ICU patients received CVVH between 2020/10/01 - 2021/12/31 (after utilization of built-in calculator) received regular protocol of ICU patient care (same in two groups) | Device: Built-in calculator to calculate Filtration fraction<br>* A calculator built in electronic CVVH prescription system to calculate Filtration fraction<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | Patient death | 30 days, 60 days, through study completion, an average of 1.5 year mortality in ICU and in Hospital | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Filter clotting events | Filter clotting events | through the complete treatment course hours, an average of 24 hours | 
| Filter lifespan | average treatment time per filter | through the complete treatment course hours, an average of 24 hours | 
| electrolytes_1 |  | the last record received before CVVH (in an average of 1 hour), the first record received CVVH after 24 hours, the first record received after CVVH (in an average of 1 hour) | 
| electrolytes_2 | K | the last record received before CVVH (in an average of 1 hour), the first record received CVVH after 24 hours, the first record received after CVVH (in an average of 1 hour) | 
| electrolytes_3 | Ca | the last record received before CVVH (in an average of 1 hour), the first record received CVVH after 24 hours, the first record received after CVVH (in an average of 1 hour) | 
| electrolytes_4 | P | the last record received before CVVH (in an average of 1 hour), the first record received CVVH after 24 hours, the first record received after CVVH (in an average of 1 hour) | 
| acid-base balance_1 | pH | the last record received before CVVH (in an average of 1 hour before CVVH treatment), the first record received CVVH after 24 hours (in an average of 1 hour after CVVH treatment), the first record received after CVVH (in an average of 1 hour after CVVH) | 
| acid-base balance_2 | bicarbonate | the last record received before CVVH (in an average of 1 hour before CVVH treatment), the first record received CVVH after 24 hours (in an average of 1 hour after CVVH treatment), the first record received after CVVH (in an average of 1 hour after CVVH) | 
| Filter downtime | downtime between filter replacement | through the complete treatment course hours, an average of 24 hours | 
| others_1 | body temperature | the last record received before CVVH (in an average of 1 hour before CVVH treatment), the first record received CVVH after 24 hours (in an average of 1 hour after CVVH treatment), the first record received after CVVH (in an average of 1 hour after CVVH) | 
| others_2 | platelet | the last record received before CVVH (in an average of 1 hour before CVVH treatment), the first record received CVVH after 24 hours (in an average of 1 hour after CVVH treatment), the first record received after CVVH (in an average of 1 hour after CVVH) |