Diagnosis Of Vertigo With New Imaging

Study Overview
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Brief Summary
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The purpose of this study is to determine the potential usefulness of new functional MRI in diagnostic assessment of patients presenting with vertigo.

Detailed Description
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The incidence of vertigo has been reported to be as high as 1.5% in the general population and some reports suggest that more than 5% of adults experience some kind of vertigo each year. In 80% of affected individuals, this symptom resulted in a medical consultation, interruption of daily activities, or sick leave. Therefore, vertigo can have a significant impact on health and well being. Unfortunately, there is not yet any satisfactory objective method for diagnosis of vertigo. At present, the diagnosis usually depends on medical history, vestibular function tests, Dix-Hallpike positioning tests done in the office, and, to some extent imaging studies doen to look for such abnormalities such as acoustic tumor, brain tumor, and evidence of multiple sclerosis. A number of recent studies support the possibility of using functional MRI (fMRI), particularly a new diffusion tensor fiber tracking (DTT) technique, as a new tool for diagnosis of disorders that can cause vertigo. In this study, our hypothesis is that there is an alteration in the activity in neural pathways of patients with vertigo that can be detected by fMRI. To test this assumption, our objective in this study is to determine whether there is a difference between the fMRI images obtained in normal subjects versus those in patients with vertigo.

Official Title
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New Diagnosis Of Vestibular Vertigo With Functional MRI

Conditions
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Vertigo

Intervention / Treatment
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* Device: Functional MRI imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy volunteer or patient with symptom of vertigo Exclusion Criteria: Evidence of mental impairment Any type of bioimplant or any type of ferromagnetic bioimplant Pregnant females Exhibit noticeable anxiety and/or claustrophobia History of serious disease in central nervous and cerebrovascular systems.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy<br>Healthy volunteers devoid of any ear problems | Device: Functional MRI imaging<br>* The functional MRI imaging of whole brain will be obtained before, during and after the vestibular response which is induced by the designated caloric stimulation. Post-imaging analysis will reveal which region or neural pathways in the central nervous system may attributed to the development of vertigo.<br>* Other names: Magnetic Resonance Imaging;|
| Vertigo<br>Patients with the symptoms of vertigo | Device: Functional MRI imaging<br>* The functional MRI imaging of whole brain will be obtained before, during and after the vestibular response which is induced by the designated caloric stimulation. Post-imaging analysis will reveal which region or neural pathways in the central nervous system may attributed to the development of vertigo.<br>* Other names: Magnetic Resonance Imaging;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Activation of target sites on the functional MRI images during the vestibular response |  | Not specific | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differences in the fiber tracking of central nervous system specifically involved in the vestibular response |  | Not specific | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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functional magnetic Resonance Imaging, vertigo, vestibular