Fractal Analysis Method in Periodontal Disease

Study Overview
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Brief Summary
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In this study, the effects of periodontal disease on alveolar bone were investigated using fractal analysis method.

Detailed Description
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Background: It is very difficult to objectively evaluate the negative changes in bone structure due to periodontitis. The present study was aimed to evaluate the trabecular bone changes between healthy individuals and periodontitis patients by fractal dimension analysis on digital panoramic radiographs. Method: The study included 50 periodontally healthy individuals (control group), 50 individuals with Stage 1 periodontitis (S1-P group), 50 individuals with Stage 2 periodontitis (S2-P), and 50 individuals with Stage 3 periodontitis (S3-P), a total of 200 individuals were included. The fractal dimension (FD) value of the trabecular bone in the interproximal space between mandibular first molar and second premolar tooth roots was evaluated using Image J program. The mean fractal dimension values of the two regions were calculated by box counting method.

Official Title
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Evaluation of Trabecular Bone Changes in Individuals With Periodontal Disease Using Fractal Analysis

Conditions
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Periodontal Diseases

Intervention / Treatment
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* Other: fractal analysis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18-65 years old Getting a diagnosis of stage 1,2 and 3 periodontitis Be diagnosed as periodontally healthy Have no barriers to obtaining radiographs Not having any systemic disease that may affect periodontal status Not smoking and alcohol use Volunteer to participate in the study Exclusion Criteria: Those who use drugs that can affect bone metabolism Radiographs with poor diagnostic quality Root canal treatment or teeth with periapical lesions in the area of interest Individuals who have suffered a fracture or trauma that affects the anatomy or integrity

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: periodontally healthy individuals<br>50 subject without any periodontal disease | Other: fractal analysis<br>* fractal analysis is a method that numerically expresses bone changes.<br>|
| Experimental: Stage 1 periodontitis<br>50 subject diagnosed with stage 1 in the periodontal disease classification | Other: fractal analysis<br>* fractal analysis is a method that numerically expresses bone changes.<br>|
| Experimental: Stage 2 periodontitis<br>50 subject diagnosed with stage 2 in the periodontal disease classification | Other: fractal analysis<br>* fractal analysis is a method that numerically expresses bone changes.<br>|
| Experimental: Stage 3 periodontitis<br>50 subject diagnosed with stage 3 in the periodontal disease classification | Other: fractal analysis<br>* fractal analysis is a method that numerically expresses bone changes.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of the effect of periodontal disease on alveolar bone by fractal analysis | Fractal dimension evaluation can give an objective result about the effect of periodontal disease on alveoler bone, since it shows changes in bone trabeculation numerically. | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Probing pocket depth | Probing pocket depth(PPD) was measured for determining the severity of the disease and clinical outcome. High probing pocket depth shows more severe periodontal disease. | baseline | 
| gingival index | The differences in gingival index scores between periodontally healthy and periodontitis.The gingival index was recorded for determining and classifying gingival status. The Gingival İndex(GI) scores each site on a 0 to 3 scale with 0 being normal and 3 being severe inflammation characterized by edema, redness, swelling and spontaneous bleeding. | baseline | 
| plaque index | The differences in plaque index scores between periodontally healthy and periodontitis. Plaque index(PI) was recorded for determining and classifying oral hygiene status. The plaque index(PI) scores each site on a 0 to 3 scale with 0 being no plaque in the gingival area and 3 abundance of soft matter within the gingival pocket and/or on the gingival margin and adjacent tooth surface. | baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Digital Radiography, Fractal Analysis, Periodontitis