Procalcitonin and Threatened Premature Delivery

Study Overview
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Brief Summary
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Among all patients hospitalized for Threatened Premature Delivery (TPD), the rate of premature birth (PB) before 37 weeks is about 42%, which reflects the inability to accurately identify patients at high risk of PB. Currently, no clinical or biological marker is recognized as the most reliable in predicting the real risk of AP in case of MAP. The purpose of this study is to improve the knowledge of predictors of preterm delivery compared with conventional blood markers by estimating serum procalcitonin according to premature delivery or not in patients hospitalized for preterm labor .

Official Title
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Procalcitonin and Threatened Premature Delivery

Conditions
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Pregnancy, Premature Delivery

Intervention / Treatment
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* Other: procalcitonin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age > 18 year Ongoing pregnancy with a start date of pregnancy known and confirmed by an ultrasound of the 1st Quarter performed between 10 and 14 weeks with a measurement of the crown-rump length hospitalization for preterm labor between 24 and 36 weeks of gestation Intact membranes, not opposed to participate in the study Exclusion Criteria: Pregnancy uncertain term (no early ultrasound) Pregnancy combining a condition that can interfere with the assays performed, Uterine malformation known Multiple pregnancy, Premature rupture of membranes, Chrorio-amnionitis, Fetal malformation known Strapping GB> 15000 and CRP> 10 mg / L, No affiliation to a social security scheme. Woman with a measure of legal protection

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Premature birth<br>At the end of the study patients will be divided into two groups: Premature delivery versus No premature delivery. Prematurity is defined as a birth before 37. In each group, the procalcitonin rate be estimated with a confidence interval of 95% and compared from a logistic regression. | Other: procalcitonin<br> <br> |
| Other: Not premature birth<br>At the end of the study patients will be divided into two groups: Premature delivery versus No premature delivery. Prematurity is defined as a birth before 37. In each group, the procalcitonin rate be estimated with a confidence interval of 95% and compared from a logistic regression. | Other: procalcitonin<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| procalcitonin rate | Estimate serum procalcitonin according to premature or not in patients hospitalized for preterm labor. | up to 48 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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pregnancy, premature birth, procalcitonin