linjc16/ctgov huggingface dataset:
Variation of Aortic Compliance Related to Exercise Training With or Without Supervised Sessions

Study Overview
=================
Brief Summary
-----------------
Many conditions and cardiovascular diseases (including stroke) are better managed with regular exercise training. The expected effects are partial reversal of adverse effects on heart and blood vessel structure and function, improved glycemic, tension and weight control. Physiologically, the aorta maintains low left ventricular after-load, promotes optimal sub-endocardial coronary blood flow, and transforms pulsatile into laminar blood flow. Increased aortic stiffness may ultimately contribute to left ventricular dysfunction. Regular exercise training is likely to decrease the pulse wave velocity (a measure of the aortic compliance). Some subjects seem more responsive than others, and they may not expect the same benefit of exercise training. To the best of our knowledge, this has not been explained yet.

Official Title
-----------------
Exercise Training in Patients With Cardiovascular Risk: Predictability of Aortic Compliance Normalization

Conditions
-----------------
Cardiovascular Disease

Intervention / Treatment
-----------------
* Procedure: Exercise training with supervised sessions


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients aged 50-69 years, with moderate or high cardiovascular risk Exclusion Criteria: any physical or medical problem liable to limit the patient' ability to perform the cardiopulmonary exercise testing or the exercise training in safe conditions.

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 69 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Medical supervision<br>Exercise training with supervised sessions Classics training | Procedure: Exercise training with supervised sessions<br> <br> |
| Active Comparator: No medical supervision<br>Exercise training without supervised sessions Classics training | Procedure: Exercise training with supervised sessions<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pulse wave velocity |  | With or without the exercise training | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart rate variability |  | within 12 weeks after exercise training | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
moderate risk, high risk
Perfusion Index as an Objective Measure for Postoperative Pain Assessment in Pediatric Patients.

Study Overview
=================
Brief Summary
-----------------
It has been demonstrated that infants and children experience pain in a similar manner to adults, however it used to be undertreated when compared to adult. Perfusion Index (PI) derived from pulse plethysmography waveform, represents a ratio of pulsatile signal (during arterial inflow) to non-pulsatile signal. PI can represent the peripheral perfusion dynamics due to change of peripheral vasomotor tone. Low PI values suggest peripheral vasoconstriction and high PI values suggest peripheral vasodilation. The sympathetic nervous system is inherently involved in the pathophysiological responses evoked by painful stimulation. In the current study, investigators hypothesise that the PI could be a good objective tool for assessment of postoperative pain in children undergoing adenotonsillectomy.

Official Title
-----------------
Evaluation of Perfusion Index as an Objective Measure for Postoperative Pain Assessment in Pediatric Patients Undergoing Adenotonsillectomy. An Observational Study.

Conditions
-----------------
Postoperative Pain

Intervention / Treatment
-----------------
* Other: postoperative pain assessment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: ASA physical status I-II Age 3 to 7 years Children undergoing adenotonsillectomy. Exclusion Criteria: Parents' refusal. Children with behavioral changes Children with physical developmental delay Children on treatment with sedative or anticonvulsant.

Ages Eligible for Study
-----------------
Minimum Age: 3 Years
Maximum Age: 7 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: postoperative pain assessment|evaluation of the efficacy of PI as an objective measure for postoperative pain assessment in pediatric population undergoing adenotonsillectomy.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between postoperative (Children's Hospital of Eastern Ontario Scale ) CHEOPS score and postoperative perfusion index. |  | the time span between arrival to PACU and for at least two hours postoperative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| validity of perfusion index to predict postoperative pain and the need of rescue analgesia |  | he time span between arrival to PACU and for at least two hours postoperative |
Physiological Data in the Menstrual Cycle

Study Overview
=================
Brief Summary
-----------------
Research results suggest changes of physiological parameters such as heart rate, respiration, skin conductance response, sleep duration, sleep quality and skin perfusion during the menstrual cycle. Latest fitness trackers allow to conveniently and non-invasively record these parameters. The present study aims to evaluate whether there is a correlation between physiological parameters and the menstrual cycle i.e. ovulation as measured by a urine ovulation test and the onset of menses. To collect data women will wear two smartwatches and a smartshirt at night. All three devices are CE-approved for sports and fitness.

Official Title
-----------------
Variations of Physiological Data Throughout the Menstrual Cycle

Conditions
-----------------
Fertility

Intervention / Treatment
-----------------
* Device: Participants wear a sensor bracelet for collecting physiological data and conducted urine tests to estimate the day of ovulation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy, non-pregnant women aged 20-40 years (healthy volunteers) Regular cycling (28 days +/- 2) Non-hormonal contraception methods used German-speaking Written informed consent to participate in the study Exclusion Criteria: Any health-related issues that may affect menstrual cycle Any consumption of medication or other substances that may affect the menstrual cycle or any of the physiological parameters investigated Frequent travel between time zones Sleeping disorders

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Participants wear a sensor bracelet for collecting physiological data and conducted urine tests to estimate the day of ovulation|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between menstrual cycle dynamics and physiology | Correlation between a combination of the physiological parameters heart rate, respiration, skin conductance response, sleep duration, sleep quality and skin perfusion and menstrual cycle dynamics. | During 1 menstrual cycle between 24 days and 35 days |
Frequency of Female Athlete Triad Among Elite Female Athlete of Iran in Different Sport in 2007

Study Overview
=================
Brief Summary
-----------------
Women's evermore presence in professional and athletic sports has revealed sound evidence on the existence of female athlete triad among the world's elite female athletes. This triad consists of eating disorders, amenorrhea and osteoporosis. It has been stated that all female athletes are potentially at risk, but it is not clear to what extent those exercising at different levels are at risk of this syndrome/triad. Since the manifestation of this triad is often denied, or under-reported, appropriate screening methods are required to identify the symptoms. There is still no clear-cut information available on the incidence of this triad in Iran. And there are religious and cultural differences between Iran's elite female athletes and those in other countries. Therefore, in order to meet Iranian female athletes' needs, the investigators decided to determine the frequency of the female athlete triad in Iran.

Official Title
-----------------
Screening of Menstrual Disorder in Elite Feamle Athlete in Iran

Conditions
-----------------
Menstruation Disturbances, Eating Disorder, Bone Loss

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All Elite Female athletes who play in international teams in sport federation or champion Team in Tehran between 13-45 years old. Exclusion Criteria: The 13-15 year old female athletes who are not manarch with secondary sex charactristics.

Ages Eligible for Study
-----------------
Minimum Age: 13 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Female athlete Triad syndrom was based on menstrual disorder,Eating Disorder and bone loss | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of Female Athlete Triad among Elite female athlete in Iran in 2006 |  | 24 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prevalence of menstrual disorder in female athlete in Iran in 2006 |  | 24 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Female Athlete Triad syndrom, Eating disorder, osteoprosis
Ultrasonographic Evaluation of Drug Spread in Epidural Space During Caudal Block in Children

Study Overview
=================
Brief Summary
-----------------
Caudal block is the world-widely used technique for an effective postoperative analgesia in children undergoing OPD-based infra-umbilical surgery. Because the caudal block is usually performed with a single-shot, proper dosage is required to achieve sufficient analgesic levels. Several clinical researches have been performed to assess the drug spread levels using mathematical equation, X-ray evaluation, and ultrasonography during caudal block in children. In our previous study using fluoroscopy, we obtained the results that the established weight-based doses provided adequate block levels for each type of surgery. Ultrasonography is precise tool to evaluate the spinal structures and can provide estimated information in real time during caudal or epidural block in children. The aim of this study is to evaluate the drug spread level with a weight-based doses using ultrasonography during caudal block in children and assess the reliability of the real time ultrasonography to determine the drug spread levels. After general anesthesia, the patient will be placed in lateral decubitus position for caudal block. Total 1.5 ml/kg of 0.15% ropivacaine will be injected into the caudal space. The spread level will be step-wise evaluated using ultrasonography at the injected drug dose of 0.5 ml/kg, 1.0 ml/kg, 1.25 ml/kg, and 1.5 ml/kg.

Conditions
-----------------
Children Who Need Urological Surgery

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: children who needed caudal block for postoperative analgesia (age 3 months   5 years old) Consent from one of parents 3. ASA physical status I or II Exclusion Criteria: bleeding tendency spinal anomaly infection focus on back allergic reaction to local anesthetics foreigner of illiteracy who cannot read consent form

Ages Eligible for Study
-----------------
Minimum Age: 3 Months
Maximum Age: 5 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1<br>4 times evaluation according to doses in 1 group | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| drug spread level with a weight-based doses | spread levels of drug within the epidural space during drug injection with caudal block at every doses using real-time ultrasound examination. maximum spread levels within the epidural space | every 10 seconds for 1 minute during drug injection (10, 20, 30, 40, 50, and 60 seconds). | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
caudal block, children, ultrasound, urological surgery
ECMO Treatment of Children in China in the Past 10 Years

Study Overview
=================
Brief Summary
-----------------
It is a cross-sectional study to summarize the extracorporeal membrane oxygenation （ECMO）treatment in children in China.

Detailed Description
-----------------
ECMO treatment in children is still in its infancy in China, and it has made considerable progress in recent years. In order to further understand the development of ECMO treatment in critically ill children, the investigator conduct this cross-sectional research through questionnaires. The investigator collect general information of the hospital and ECMO equipment, etiology, compilation, and mode of ECMO.

Official Title
-----------------
Extracorporeal Membrane Oxygenation (ECMO) Treatment of Children in Mainland China in the Past 10 Years

Conditions
-----------------
Extracorporeal Membrane Oxygenation, Child, Only

Intervention / Treatment
-----------------
* Procedure: ECMO


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age of 1d to 18 years old; children supported by ECMO in mainland China in the past 10 years Exclusion Criteria: none

Ages Eligible for Study
-----------------
Minimum Age: 1 Day
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| ECMO group<br>children supported by ECMO in the past 10 years | Procedure: ECMO<br>* ECMO is a form of Extracorporeal Life Support (ECLS) to support either the pulmonary, or both the pulmonary and cardiac systems.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| survival rate | survival rate after discharge | from admission to discharge （about 10days） | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| time of running ECMO | the total time of running ECMO | from admission to discharge（about 10days） | 
| cost of ECMO treatment | the total cost of ECMO treatment | from admission to discharge （about 10days） | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Extracorporeal membrane oxygenation; children; complication
Social Media Effects on Mental Health

Study Overview
=================
Brief Summary
-----------------
In the last decade, research on social media and mental health has produced mixed results. Overall, the current findings suggest that the negative effects on mental health are exacerbated by longer and more frequent social media usage, whereas the positive effects are bolstered when social media is used to connect with other people. With the largest number of global users, Facebook is the most frequently studied social media network. Over the past few years, the increasing concerns about the risks associated with Facebook have even translated to wider pop culture conversations, as exemplified by the 2020 documentary The Social Dilemma. In response, Facebook has rolled out a series of features supposed to mitigate these risks and encourage responsible social media usage. These features include activity trackers and reminders, unfollow and snooze buttons, and data sharing regulators. Currently, there is no research done to address whether (1) these features are used at all, and (2) whether they are successful in moderating the negative mental health consequences of Facebook usage. This study seeks to address the gap in literature through a survey done on the crowdsourcing platform Amazon Mechanical Turk (MTurk).

Official Title
-----------------
How Do We Resolve the Social Dilemma? Facebook Features Use as a Moderator of Mental Health.

Conditions
-----------------
Mental Health Issue, Mental Health Wellness 1, Mental Health Wellness 2, Social Media Addiction, Internet Addiction

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy adult volunteers, aged 21 and above English proficiency Facebook users Exclusion Criteria Participants below 21 years old Non-Facebook users

Ages Eligible for Study
-----------------
Minimum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mental Health Scores | Depression, Anxiety, and Stress Scale (DASS-21), (measured on a 4 point scale: min = 0, max = 3; higher scores indicating higher depression, anxiety and/or stress). | Once during the survey. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Social Media, Facebook, Mental Health, Wellbeing
Comparison the Safety and Pharmacokinetic Characteristics of DWP422 25 mg With Those of ENBREL 25MG PFS INJ. After Subcutaneous Injection in Healthy Male Volunteers

Study Overview
=================
Brief Summary
-----------------
The purpose of this study was to compare the safety and pharmacokinetic characteristics of DWP422 25 mg with those of ENBREL 25MG PFS INJ. after subcutaneous injection in healthy male volunteers.

Official Title
-----------------
A Randomized, Double-blind, Single-dosing, Crossover Study to Compare the Safety and Pharmacokinetic Characteristics of DWP422 25 mg With Those of ENBREL 25MG PFS INJ. After Subcutaneous Injection in Healthy Male Volunteers

Conditions
-----------------
Rheumatoid Arthritis

Intervention / Treatment
-----------------
* Drug: DWP422 25mg
* Drug: ENBREL 25MG PFS INJ.


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy males, 20 to 45 years of age the moment of screening Body mass index is between 19.0 and 27.0 kg/m2 Exclusion Criteria: Hypersensitivity response to the experimental and comparator drugs The tuberculosis patient or latent tuberculosis patient

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: DWP422<br> | Drug: DWP422 25mg<br> <br> |
| Active Comparator: ENBREL<br> | Drug: ENBREL 25MG PFS INJ.<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Etanercept levels in blood |  |  |
A Study of PC Sequential Pemetrexed Single Drug Maintenance Treatment for NSCLC and Related Predictive Biomarkers

Study Overview
=================
Brief Summary
-----------------
PFS

Official Title
-----------------
Advanced Metastatic Non-small Cell Lung Cancer Patients Aged or PS Score 2 Points for First Line Application Pemetrexed/Carboplatin Chemotherapy Regimens Sequential Pemetrexed Single Drug Maintenance Treatment of Clinical Research and Related Predictive Biomarkers of Exploratory Research

Conditions
-----------------
Non-small Cell Lung Cancer

Intervention / Treatment
-----------------
* Drug: pemetrexed /carboplatin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: .≥65 years or PS 2 Patients who were diagnosed by the histologic, cytologic diagnosis of IV non-small cell lung cancer Patients received no chemical therapy or only received targeted therapy,and there is evidence show the patent is PD Presence of at least one index lesion measurable by CT scan or MRI leucocyte ≥ 3.5×109/L neutrophil ≥ 1.5×109/L platelet ≥ 80×109/L Hemoglobin ≥ 9g/L ALT and AST ≤ 2.5×ULN ,Tbil≤ 1.5×ULN BUN≤ 1.5×ULN Signed written informed consent Exclusion Criteria: squamous carcinoma or small cell lung cancer Patients were allergic to pemetrexed Patients received chemotherapy before Uncontrolled acute infection .Uncontrolled pleural effusion Severe symptomatic heart disease Severe infection or metabolic disfunction Patients with other malignant tumor Uncontrolled brain metastases Patients have accepted other clinical trials Female patients during their pregnant and lactation period, or patients without contraception Mental disorientation of disorder Glucocorticoids taboo

Ages Eligible for Study
-----------------
Minimum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: pemetrexed<br> | Drug: pemetrexed /carboplatin<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PFS |  | from the first cycle of treatment (day one) to two month after the last cycle | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Progression free Survival