Rapid Declarative Neocortical Declarative Learning in Aging and Memory Diseases (ANéRAVIMM)

Study Overview
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Brief Summary
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Learning a person's name, new words, or simply remembering where the last conversation with a friend was held are examples of associative memory, frequently disturbed in brain pathologies, but also by aging. Although typically dependent on the hippocampus in the brain, a series of findings suggest that associative memory may persist, under certain circumstances, despite hippocampal damage. The ANéRAVIMM project aims to reveal this learning system, its cognitive and cerebral bases, and to evaluate its potential in patients with memory disorders.

Detailed Description
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Three experimental cognitive tasks will be used in the ANéRAVIMM study. The first two tasks have been selected based on the literature and previous work of CHU Rennes team. They are two experiments that have produced promising results concerning the existence of a rapid neocortical learning system in declarative memory, and have in common the use of prior knowledge to promote learning. In the first part of the study, these two tasks will be put in competition for their resistance to the effects of age. Brain aging is characterized by its deleterious impact on hippocampal functioning, and memory aging leads to an alteration of associative memory. Therefore, this first part will allow the learning paradigm that presents the best potential in brain-damaged patients to be retained in the second part of the ANéRAVIMM study. The third task stems from recent work by CHU Rennes team in collaboration with Dr. Besson of the University of Liege, in the context of a very recent model of memory. It aims at estimating the ability to develop a representation of visual objects in memory at the entity level, i.e. an integrated representation, unifying all the perceptual, conceptual and contextual features of perceived information. This task has been adapted for the ANéRAVIMM project in order to test the hypothesis that this mnemonic representational level of the entity in memory could support rapid neocortical associative learning in declarative memory.

Official Title
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Rapid Declarative Neocortical Declarative Learning in Aging and Memory

Conditions
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Neurological Diseases, Central Nervous System

Intervention / Treatment
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* Other: Neuropsychological tests


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy Volunteers aged 18 to 40 years old and aged 60 to 80 years old native French speaker right-handed with a level of education greater than or equal to the Certificate of Primary Education free of any medical or psychiatric condition that may interfere with cognition Neurological patients patients with mild neurocognitive impairment due to Alzheimer's disease patients with semantic dementia syndrome right-handed patients with a right or left unilateral surgical lesion of the anterior temporal lobe as a result of pharmaco resistant temporal epilepsy, with no seizures in the last 6 months, with a memory quotient greater than 75, and free of internal extra temporal lesions on MRI patients with autoimmune limbic encephalitis who have been seizure-free for one month 1 KA patient, suffering from the rare syndrome of developmental amnesia Exclusion Criteria: All participants MRI contraindications sensory deficit interfering with experimental tests protected major (safeguard justice, trusteeship and guardianship) and persons deprived of liberty Healthy volunteers - deficit score on the MoCA scale according to current calibrations Neurologic patients 7-items modified Hachinski ischemic score >2 dementia epileptic seizure in the month prior to inclusion for epileptic patients undergoing surgery and limbic encephalitis patients

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Healthy volunteers<br>60 healthy volunteers (aged 18-40 and 60-80) will undergo an inclusion visit in order to check inclusion and non inclusion criteria. Then will be performed: Visit 1 Neuropsychological tests A cranial MRI Visit 2 • Neuropsychological tests | Other: Neuropsychological tests<br>* Scales and tests to evaluate: laterality anxiety depression professional level education level pre-morbid level memory disorders Experimental procedure<br>|
| Experimental: Patients with neurological diseases of the central nervous system<br>36 patients will undergo an inclusion visit in order to check inclusion and non inclusion criteria. Then will be performed: Visit 1 Neuropsychological tests A cranial MRI Visit 2 • Neuropsychological tests | Other: Neuropsychological tests<br>* Scales and tests to evaluate: laterality anxiety depression professional level education level pre-morbid level memory disorders Experimental procedure<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference between young and old healthy subjects in experimental associative memory scores |  | Up to 1 month (time to perform the second visit) | 
| Difference between healthy subjects and patients with SSHA damage in experimental associative memory scores |  | Up to 1 month (time to perform the second visit) | 
| Correlations between SSHA volumes and experimental associative memory scores in healthy subjects and patients with SSHA damage |  | Up to 1 month (time to perform the second visit) | 
| Correlations between rest-related functional connectivity within the Medial Temporal Lobes and experimental associative memory scores in healthy subjects |  | Up to 1 month (time to perform the second visit) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Presence of significant correlations between memory scores for entity-level mnemonic representations and experimental associative memory scores in healthy subjects |  | Up to 1 month (time to perform the second visit) |