Evaluation of Sticky Bone With or Without EDTA for Treatment of Gingival Recession

Study Overview
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Brief Summary
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Gingival recession is a common clinical finding in periodontal disease which is frequently associated with esthetic concerns, root hypersensitivity, and root caries. Many surgical therapeutic approaches have been developed to predictably obtain root coverage of gingival recession defects. Injectable PRF (I-PRF) is the liquid form of PRF. I-PRF is a bioactive agent obtained by low-speed centrifugation, and it has the capacity to stimulate tissue regeneration. At high concentrations, PRF may stimulate the secretion of several growth factors and trigger fibroblast migration. I-PRF is generally used in regenerative treatments, with good outcomes. Ethylenediaminetetraaceti acid (EDTA) is a chelating agent that could enhance the attachment of connective tissue to the root surface by exposing collagen and, as a consequence, enhance root coverage. EDTA works at neutral pH, and this property has been reported to preserve adjacent tissue vitality. The present study will be carried out to evaluate the effect of sticky bone with or without EDTA root surface biomodification for treatment of gingival recession.

Official Title
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Evaluation of Sticky Bone With or Without EDTA Root Surface Biomodification for Treatment of Gingival Recession: Randomized Controlled Clinical Study

Conditions
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Gingival Recession

Intervention / Treatment
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* Procedure: Sticky bone and EDTA
* Procedure: Sticky bone


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Miller I/II isolated maxillary recession defects. No abrasion, caries, or cervical restorations and presence of identifiable cementoenamel junction (CEJ). No occlusal interferences. Full-mouth plaque index (PI) and gingival index (GI) scores of < 1. Non-smokers. Exclusion Criteria: Pregnant patients Presence of systemic disease or taking medication that interfere with periodontium

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: sticky bone and EDTA<br>treatment of gingival recession using sticky bone after root surface biomodification with EDTA | Procedure: Sticky bone and EDTA<br>* treatment using Sticky bone after EDTA root surface biomodification<br>|
| Active Comparator: Sticky bone<br>treatment of gingival recession using sticky bone | Procedure: Sticky bone<br>* treatment using Sticky bone<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| clinical evaluation of root coverage | the percentage of root coverage will be calculated in millimeter | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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i-PRF, EDTA