Observational Study on the Clinical Impact of Desaturation During Liver Surgery

Study Overview
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Brief Summary
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The purpose of this study is to determine the clinical impact of cerebral and systemic desaturation during liver transplantation and resection on post-operative complications.

Detailed Description
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This is an observational study. Cerebral and systemic oxymetry (rSO2) using near infrared spectroscopy (NIRS, Invos 5100; Somanet- ics Corporation, Troy, MI) will be performed on all patients with 4 optodes (right and left temporal area, arm and leg). Continuous rSO2 values will be stored on a hard disk with a 15 seconds update within intraoperative period and first 4 hours after the surgery. Desaturation phases (saturation decrease more than 20% of the basal value for more than 15 seconds) will be correlated to operative procedure or events. Postoperative adverse events will be collected. A correlation between desaturation and postoperative adverse events will be done with a multiple linear regression model.

Official Title
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Observational Study on the Clinical Impact of Systemic and Cerebral Desaturation During Liver Transplantation and Hepatectomy

Conditions
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Cerebral Desaturation

Intervention / Treatment
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* Other: systemic and cerebral oxymetry


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients undergoing an hepatic resection or hepatic transplantation patients able to give consent with knowledge of french or english language. Exclusion Criteria: age< 18 years patients with cerebral diseases

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: systemic and cerebral oxymetry|oxymetry measurement using near infrared spectroscopy|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| define the correlation coefficient between the number of systemic and/or cerebral desaturation phases and the number of postoperative adverse events |  | from the beginning of anesthesia till 4 hours after the end of the surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| define the prevalence of systemic and cerebral desaturation phases during hepatic surgery or transplantation |  | from the beginning of anesthesia till 4 hours after the end of the surgery | 
| define the correlation coefficient between systemic and/or cerebral desaturation phases and the length of stay in intensive care unit |  | duration of intensive care stay, an expected average of 4 days | 
| validate the equivalence of the systemic and cerebral oxymetry |  | from the beginning of anesthesia till 4 hours after the end of the surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cerebral oxymetry, systemic oxymetry, hepatic surgery, liver transplantation