Glucose Metabolism in Different PCOS Phenotypes

Study Overview
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Brief Summary
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In the present study glucose metabolism and ectopic lipids in the liver, heart and muscle were investigated in women with the polycystic ovary syndrome (PCOS) and in healthy control subjects.

Detailed Description
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In detail an oral glucose tolerance test (OGTT) was conducted in women with the PCOS defined by the Rotterdam and the NIH-criteria, as well as in healthy control subjects. In addition 1H-magnetic resonance spectroscopy and Imaging was used for the assessment of the ectopic lipid content in the liver, heart and skeletal muscle. The aim of the present study was to compare the glucose metabolism and the ectopic lipid conent in the liver, heart and muscle between women with the PCOS defined by the NIH-criteria, Rotterdam-criteria and healthy control subjects.

Official Title
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Associatons of PCOS Phenotypes With Ectopic Lipids, Adipocytokines and Parameters of Insulin Resistance

Conditions
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Polycystic Ovary Syndrome, Glucose Intolerance, Liver Fat, Glucose Metabolism Disorders

Intervention / Treatment
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* Diagnostic Test: Oral glucose tolerance test (OGTT)
* Other: 1H-magnetic resonance spectroscopy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Women with the polycystic ovary Syndrome defined according to the Rotterdam and the NIH-criteria healthy control subjects Exclusion Criteria: BMI>=40kg/m² Diagnosis of Diabetes in the PCOS-Group Diagnosis of Prediabetes or Diabetes in the control group

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| PCOS-NIH<br> | Diagnostic Test: Oral glucose tolerance test (OGTT)<br>* For the assessment of glucose metabolism, including beta-cell function and insulin sensitivity an 75g-OGTT was conducted.<br>Other: 1H-magnetic resonance spectroscopy<br>* The amount of ectopic lipids in the liver, heart and the skeletal muscle was measured using 1H-magnetic resonance spectroscopy.<br>|
| PCOS-Rotterdam<br> | Diagnostic Test: Oral glucose tolerance test (OGTT)<br>* For the assessment of glucose metabolism, including beta-cell function and insulin sensitivity an 75g-OGTT was conducted.<br>Other: 1H-magnetic resonance spectroscopy<br>* The amount of ectopic lipids in the liver, heart and the skeletal muscle was measured using 1H-magnetic resonance spectroscopy.<br>|
| Controls<br> | Diagnostic Test: Oral glucose tolerance test (OGTT)<br>* For the assessment of glucose metabolism, including beta-cell function and insulin sensitivity an 75g-OGTT was conducted.<br>Other: 1H-magnetic resonance spectroscopy<br>* The amount of ectopic lipids in the liver, heart and the skeletal muscle was measured using 1H-magnetic resonance spectroscopy.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of glucose metabolism between PCOS women and healthy control subjects, using data of the OGTT. | In the present study the Glucose metabolism in PCOS women and control subjects was assessed with an OGTT. Therefore the dynamic levels of glucose, insulin and C-peptide were assessed during an extended OGTT for the calculation of Insulin resistance and beta-cell function. In addition an 1H-magnetic resonance spectroscopy was done for the assessment of the ectopic lipid content in the liver, heart and the skeletal muscle. | Up to 4 weeks |