The Features Behind the Beneficial Effects of Interval-walking

Study Overview
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Brief Summary
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A single bout of Interval-Walking (IW) exercise is superior to energy-expenditure and time-duration matched Continuous Walking (CW) exercise upon improving glycemic control. The reason IW is superior is unknown. This study will look into whether it is the larger peak intensity during IW or if it is the alternating exercise pattern that is responsible for the larger improvements seen. Subjects with type 2 diabetes will be included in a crossover, counter-balanced, controlled study, where each subject will undergo three trials. Trials will be identical except the following interventions: One hour of rest (Con) One hour of classical interval walking (repeated cycles of 3 min of fast and 3 min of slow walking; IW3) One hour of fast alternating interval walking (repeated cycles of 1 min of fast and 1 min of slow walking; IW1). After the interventions subjects will undergo a standardized mixed meal tolerance test, with consecutive measurements of blood glucose, insulin and c-peptide.

Official Title
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The Features Behind the Beneficial Effects of Interval-walking

Conditions
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Diabetes Mellitus, Type 2

Intervention / Treatment
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* Behavioral: Control
* Behavioral: IW3
* Behavioral: IW1


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Type 2 diabetes mellitus Body mass index > 18 but < 40 m2/kg Agreement to pause antidiabetic medication from 2 days before to after each trial Exclusion Criteria: Pregnancy Smoking Use of exogenous insulin Contraindication to increased levels of physical activity Evidence of thyroid, liver, lung, heart or kidney disease

Ages Eligible for Study
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Minimum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Control (Con)<br>No exercise intervention. | Behavioral: Control<br>* One hour of rest.<br>* Other names: No exercise;|
| Experimental: Interval Walking - 3 min intervals (IW3)<br>One hour of classical interval walking exercise (repeated cycles of 3 min of fast and 3 min of slow walking. | Behavioral: IW3<br>* A one hour exercise bout with repeated cycles of 3 min of fast and 3 min of slow walking<br>* Other names: Interval walking - 3 min intervals;|
| Experimental: Interval Walking - 1 min intervals (IW1)<br>One hour of fast alternating interval walking exercise (repeated cycles of 3 min of fast and 3 min of slow walking | Behavioral: IW1<br>* A one hour exercise bout with repeated cycles of 1 min of fast and 1 min of slow walking<br>* Other names: Interval walking - 1 min intervals;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glycemic control | Glycemic control will be measured after each intervention. Subjects will receive a standardized mixed meal tolerance test (MMTT), and blood glucose values will be obtained during the test. | Within the first 4 hours after the interventions | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Insulin secretion | Insulin and C-peptide will be measured during the MMTT | Within the first 4 hours after the interventions | 
| Insulin sensitivity | From the measurements og glucose and insulin during the MMTT, various indices of insulin sensitivity will be assessed | Within the first 4 hours after the interventions | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Glycemic control, Exercise