Association of Donor Age With Recipient Outcomes in Kidney Transplant

Study Overview
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Brief Summary
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This is a single center study that seeks to study the impact of donor age on recipient outcomes in older kidney transplant recipients.

Detailed Description
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Over the years use of older kidney allografts has increased in an attempt to bridge the gap between demand and supply of organs. Simultaneously there has been in increase in the number of elderly renal transplant recipients. Numerous factors, both graft and host related, can impact recipient outcomes. The aim of this study is to evaluate the impact of donor age on recipient outcomes, based on the hypothesis is that elderly recipients who receive an older allograft have poorer outcomes that those who receive a younger allograft. Study subjects will be recruited from the cohort of patients who received a kidney transplant at Northwestern Memorial Hospital. The transplant clinical database and electronic medical record (OTTR) used in the Comprehensive Transplant Center at Northwestern University will be scanned to screen for kidney transplant recipients who fit the inclusion and exclusion criteria. Potential subjects will then be consented to participate in the study (see attached consent form), and subject participation will be documented in OTTR. The sample size for the study is 80 subjects, who will be divided into 2 groups based on recipient and donor age. All demographic and clinical data will be collected for the donor and recipients at time of transplant. Follow up clinical data, including but not limited to recipient survival and graft failure will be collected and analyzed for the recipients. Subject confidentiality will be strictly maintained. All subject data will be stored on a secure server and only shared between members of the research team. The investigators plan to publish the results in a peer reviewed journal.

Official Title
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Association of Donor Age With Recipient Outcomes in Kidney Transplant

Conditions
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Complication of Transplant

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All adult kidney transplant recipients Recipient age > 60 years at the time of transplant Transplant was done between January 1, 2013 and December 31, 2014 Exclusion Criteria: Recipients of more than one kidney transplant Recipients of multi-organ transplants

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Young donor<br>Kidney transplant recipient > 60 years of age who received organ from donor <=40 years of age | |
| Old donor<br>Kidney transplant recipient >= 60 years of age who received organ from donor >=50 years of age | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Graft failure | Graft failure in this study is defined as need for chronic dialysis or re-transplant. | 2 years post transplant | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recipient survival |  | 2 years post transplant | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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kidney, transplant