linjc16/ctgov huggingface dataset:
The Usefulness of Ultrasound Guided Technique Insertion of Radial Artery Catheter in Neonates and Infants

Study Overview
=================
Brief Summary
-----------------
The investigators are trying to compare the ultrasound-guided technique vs. palpation method for radial arterial cannulation in infants.

Detailed Description
-----------------
In infants (<12mo), radial arterial catheterization is sometimes difficult to perform. Moreover, repeated attempts itself would cause the arterial spasm or hematoma. The use of ultrasound as an adjunct to radial arterial cannulation has considered to be the best practice in adults and pediatrics. However, its usefulness or superiority for neonates and infants is not known. Therefore, we would compare ultrasound guided radial arterial cannulation with the usual palpation methods in infants undergoing cardiac surgery.

Official Title
-----------------
The Usefulness of Ultrasound Guided Technique Insertion of Radial Artery Catheter in Neonates and Infants

Conditions
-----------------
Catheterization, Peripheral

Intervention / Treatment
-----------------
* Procedure: Radial arterial cannulation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Infants under 12 months age undergoing cardiac surgery with radial arterial cannulation Exclusion Criteria: Sign of a skin infection Wound near the puncture site abnormal circulation of the hand any vascular problem at radial or ulnar artery

Ages Eligible for Study
-----------------
Minimum Age: 1 Day
Maximum Age: 12 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Palpation group<br>The operator will use the pulsation of the radial artery as a guide for the cannulation. | Procedure: Radial arterial cannulation<br>* Radial arterial cannulation using usual palpation method or ultrasound guided technique according to the group<br>|
| Experimental: Ultrasound group<br>The ultrasound guided technique will be used to find a radial artery and insert a radial arterial catheter. | Procedure: Radial arterial cannulation<br>* Radial arterial cannulation using usual palpation method or ultrasound guided technique according to the group<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| First-pass success rate |  | Within 10 min from the start time of arterial cannulation using an angiocath | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Peripheral, Arterial, Catheterization
Effects of Oral L-Arginine on Chronic Hypertension in Pregnancy

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the effects of oral L-Arginine in pregnant women with chronic hypertension.

Official Title
-----------------
Effects of Oral L-Arginine on Chronic Hypertension in Pregnancy

Conditions
-----------------
Hypertension in Pregnancy

Intervention / Treatment
-----------------
* Drug: L-Arginine
* Drug: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pregnant women between 18-20 week of gestation with chronic hypertension Exclusion Criteria: Maternal or fetal disease

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Oral L-Arginine 2 g twice a day for 14 weeks | Drug: L-Arginine<br>* Oral L-Arginine 2g, twice a day for 14 weeks<br>|
| Placebo Comparator: 2<br>Placebo 2 g, twice a day for 14 weeks | Drug: Placebo<br>* Placebo 2 g twice a day for 14 weeks<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| to evaluate blood pressure changes in pregnant women with chronic hypertension during oral arginine or placebo treatment in second trimester of gestation. |  | 14 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To evaluate if is necessary add a conventional therapy for hypertension, to evaluate the maternal and fetal outcomes and possible complications, to evaluate the safety of L-Arginine. |  | 14 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
chronic hypertension in pregnancy, chronic Hypertension
NAFLD in HIV-infected Patients

Study Overview
=================
Brief Summary
-----------------
The prevalence of NAFLD (nonalcoholic fatty liver disease) in HIV-infected patients is higher than that in general population, but the causes of morbidity and pathogenesis have not been fully explored. The investigators are planning to consecutively enroll 400 cases HIV-positive outpatients, and to detect NAFLD by ultrasound. The fecal and blood samples were also collected to explore the mechanism of NAFLD. The investigators aimed to determine the prevalence and risk factors of NAFLD in HIV infected patients.

Official Title
-----------------
The Epidemiological Investigation and Pathogenesis of NAFLD in HIV-infected Patients: a Cross-sectional Study

Conditions
-----------------
HIV-infection/Aids, NAFLD

Intervention / Treatment
-----------------
* Other: No intervention; cross-sectional study


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 18 70 y; HIV-positive patients; written the informed consent Exclusion Criteria: coinfected with HBV, HCV; secondary causes of fatty liver (eg, consumption of amiodarone and tamoxifen) and decompensated liver disease; significant alcohol consumption (>20 g per day for man, >10 g per day for woman); received antibiotics in preceding two months; autoimmune disease; severe heart, lung, kidney, brain, blood diseases or other important systemic diseases; pregnant or lactating women

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| HIV-monoinfected outpatients<br>No intervention; cross-sectional study | Other: No intervention; cross-sectional study<br>* No intervention; cross-sectional study<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| morbidity of nonalcoholic fatty liver disease | NAFLD was diagnosed using ultrasound | 1 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
NAFLD, HIV infection
Meconium Aspiration and Tracheal Suctioning-Feasibility Study

Study Overview
=================
Brief Summary
-----------------
Feasibility study to randomize non-vigorous newborn infants born through meconium-stained amniotic fluid to endotracheal suctioning or immediate resuscitation.

Detailed Description
-----------------
This will be a pilot feasibility trial of endotracheal intubation and suctioning versus routine resuscitation for term, non-vigorous newborns born through meconium-stained amniotic fluid to compare the incidence of meconium aspiration syndrome, extracorporeal membrane oxygenation or death.

Official Title
-----------------
Meconium Aspiration Syndrome and Non-vigorous Neonates-Pilot Study

Conditions
-----------------
Meconium Aspiration Syndrome

Intervention / Treatment
-----------------
* Procedure: Immediate intubation
* Procedure: Immediate resuscitation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Term newborns (>37 weeks of gestation) Delivery through meconium-stained amniotic fluid Mothers >18 years of age Exclusion Criteria: No consent from mother Infant vigor at delivery (muscle tone and respiratory effort) Prenatally diagnosed major anomalies (excluding gastroschisis) Plan to not resuscitate infant Family does not speak English

Ages Eligible for Study
-----------------
Maximum Age: 5 Minutes

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Immediate intubation<br>These infants will have immediate endotracheal suctioning after delivery. They will then have resuscitation per Neonatal Resuscitation Program guidelines. | Procedure: Immediate intubation<br>* Infants that are not vigorous at delivery will receive immediate tracheal suctioning<br>|
| Experimental: Immediate resuscitation<br>These infants will have immediate resuscitation per the Neonatal Resuscitation Program guidelines without endotracheal suctioning. | Procedure: Immediate resuscitation<br>* Infants that are not vigorous at delivery will receive immediate initial steps of resuscitation and PPV if needed<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ability to identify, consent, enroll and randomize 70% of eligible infants into study. | Feasibility measures | 18 months | 
| The number of infants in the study who develop meconium aspiration syndrome, require extracorporeal membrane oxygenation or die | Clinical outcome measure | 18 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
meconium, neonatal resuscitation
Maxillary Sinus Floor Elevation Using DENSAH Burs Versus Summers Osteotomes

Study Overview
=================
Brief Summary
-----------------
To investigate the efficacy of osseodensification drills (Densah bure) as a new closed sinus lift tool and to compare the effect of it in bone gaine versus traditional osteotomes.

Official Title
-----------------
Crestal Maxillary Sinus Floor Elevation Using Osseodensification Drills (Densah Burs) Versus Summers Osteotomes

Conditions
-----------------
Implant Tissue Failure

Intervention / Treatment
-----------------
* Device: densah burs osseo densification drills
* Device: Summer's Osteotomes


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with partially edentulous in the posterior area of the maxilla, with a residual ridge that allowed insertion of ≤8 mm length implants. both sexes. No intraoral soft and hard tissue pathology No systemic condition that contraindicate implant placement. Exclusion Criteria: Sinus pathology. Heavy smokers more than 20 cigarettes per day. Patients with systemic disease that may affect normal healing. Psychiatric problems. Disorders to implant are related to history of radiation therapy to the head and neck neoplasia, or bone augmentation to implant site.

Ages Eligible for Study
-----------------
Minimum Age: 25 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: densah burs drilling group<br>maxillary sinus floor elevation during implant placement using Densah burs | Device: densah burs osseo densification drills<br>* maxillary sinus floor elevation during implant placement using Densah burs<br>|
| Experimental: Summers osteotomes<br>maxillary sinus floor elevation during implant placement using Summer's Osteotomes | Device: Summer's Osteotomes<br>* maxillary sinus floor elevation during implant placement using Summer's Osteotomes<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| implant stability | measurement of implant stability using the Ostell | 6 months after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| bone gain | measurement of bone gain around implant using cone-beam computed tomography CBCT | 6 months after surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Sinus, Stability, Bone gain, Osseodensification
Study of Post-anesthesia Management in Patients Undergoing Neurosurgery

Study Overview
=================
Brief Summary
-----------------
The postoperative complications of neurosurgery are various and complex, which brings heavy economic and social burden to families. Timely detection and early intervention can help reduce the incidence of adverse events and mortality. The main purpose of this study is to analyze the possible factors related to postoperative complications of Neurosurgery, so as to achieve the prospective prevention and treatment of postoperative complications of neurosurgery.

Official Title
-----------------
A Prospective Cohort Study of Post-anesthesia Management in Patients Undergoing Neurosurgery

Conditions
-----------------
Anesthesia, Neurosurgery, Complication

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: From October 2019 to October 2022, all patients received neurosurgery in Tiantan hospital and expected to returned to PACU. Exclusion Criteria: Preoperative severe cognitive dysfunction ； Tracheal intubation remained after operation ； Refused to sign informed consent.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Postoperative complications<br> | |
| No postoperative complications<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The incidence of postoperative complications in neurosurgery. | The incidence of postoperative complications was diagnosed by the corresponding assessment scale.Complications include nausea, vomiting, delirium, delayed recovery, intracranial hematoma,etc. | 5±2 days |
Deep Brain Stimulation of the Subthalamic Nucleus (STN) and Cognitive Control

Study Overview
=================
Brief Summary
-----------------
In this study, the investigators will follow patients who have had stimulators implanted, at their usual clinic follow-up appointments 3, 6, 9 and 12 months after surgery. It is typical at these appointments for patients to be off medication and for the stimulators to be turned off to observe disease progress and test stimulator effectiveness. Also as part of standard clinical practice, stimulator settings are adjusted for optimal benefit to motor symptoms. Only patients who already have implants will be invited to participate in this study, and no changes to stimulator settings are made for the purposes of this study. Stimulator settings are changed based on clinical evaluation of motor symptoms, and this study has no bearing on how stimulators will be set nor how often they will be set.

Official Title
-----------------
Deep Brain Stimulation of the STN and Cognitive Control: A Pilot Study

Conditions
-----------------
Parkinson's Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Meet criteria for definite Parkinson's Disease (PD) STN stimulators on both sides (right and left) Surgery done at Washington University within 2 years Exclusion Criteria: Significant visual deficits (e.g. double vision, untreated eyelid apraxia, blepharospasm) Must be able to see screen Secondary Parkinsonism (drug-induced or other known etiologies) Brain injury or defect: history of serious head injury, stroke, encephalitis, defect found on brain imaging Early severe dementia (within first year of onset) or on cholinesterase inhibitors Pre-surgical Mini Mental Status exam score < 24 Significant current psychiatric diagnoses (such as depression or psychosis) or on neuroleptics
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Parkinson's Disease, STN DBS, Deep Brain Stimulation
A Study to Determine the Safety and Tolerability of Escalating Doses of INS365 Ophthalmic Solution

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the safety and tolerability of INS365 Ophthalmic Solution when applied topically as eyedrops in patients with mild to moderate dry eye disease.

Official Title
-----------------
A Double-Masked, Randomized, Placebo-Controlled, Rising-Dose Study of Multiple Ocular Instillations of INS365 Ophthalmic Solution in Patients With Mild to Moderate Dry Eye Disease.

Conditions
-----------------
Dry Eye Disease

Intervention / Treatment
-----------------
* Drug: diquafosol tetrasodium (INS365) ophthalmic solution


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Best corrected visual acuity 20/40 in each eye 2 out 5 specified symptoms Corneal fluorescein staining score greater than or equal to 3 out of 15 Exclusion Criteria: Unable to stop concomitant medications Have had intraocular surgery in previous 90 days Have excluded systemic or ocular disease Wear contact lenses and are not willing to remove them Have intraocular pressure greater than 22 mg Hg

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: diquafosol tetrasodium (INS365) ophthalmic solution|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of adverse events |  |  | 
| Ocular symptomatology |  |  | 
| Visual acuity |  |  | 
| Biomicroscopy |  |  | 
| Ophthalmoscopy |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Unanesthetized Schirmer test |  |  |
Effects of Antimuscarinic Drugs on Overactive Bladder (OAB) Symptoms After Insertion of Ureteral Stents

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to check whether antimuscarinics that usually broadly used in the treatment of overactive bladder symptoms are effective in the treatment of those symptoms after insertion of ureteral stents. In order to study the efficacy of the treatment of OAB symptoms in stented patients the investigator will use a suitable questionnary.

Official Title
-----------------
Effects of Antimuscarinic Drugs on OAB Symptoms After Insertion of Ureteral Stents

Conditions
-----------------
Overactive Bladder

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: everyone who underwent ureteral stent insertion and started the treatment with detrusitol Exclusion Criteria: adverse affects of detrusitol or unwillness of the patient to continue the treatment with detrusitol, cronic renal or hepatic failure

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Ureteral stents Detrusitol treatment Lyfestyle outcome<br>Ureteral stents Detrusitol treatment Lyfestyle outcome | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
detrusitol, overactive, bladder, ureteral, stents