The Effect of Preoperative NLR Level on Epidural Analgesia Application in Thoracotomy

Study Overview
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Brief Summary
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The aim of this study is to investigate the relationship of preoperative Neutrophil/Lymphocyte Ratio (NLR) with postoperative pain and the effect of preoperative NLR level on timing of epidural analgesia in thoracotomy.

Detailed Description
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The study was conducted prospectively in 60 patients aged 18-75 years, ASA I-III, who underwent thoracotomy. The patients were divided into 2 groups as NLR level above 2 (Group A) (n:32) and NLR level below 2 (Group B) (n:28). Each group was divided into subgroups with equal numbers of Prempative analgesia group and control group. Local anesthetic was administered to the preemptive analgesia group (Group P) 20 minutes before the surgical incision through the epidural catheter, and to the control group (Group K) 20 minutes before the patient was awakened from the epidural catheter. NRS levels and additional analgesia needs were recorded at 2, 4, 8, 12 and 24 hours postoperatively.

Official Title
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The Effect of Preoperative NLR Level on Epidural Analgesia Application in Thoracotomy

Conditions
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C23.550.767.700, C23.550.470

Intervention / Treatment
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* Diagnostic Test: Neutrophil Lynphosite ratio


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient graded as American Society of Anesthesiologist (ASA) physical status, I, II or III Patient subjected to thoracotomy operation Exclusion Criteria: Patient having morbid obesity, Patient having renal failure, Patient having hepatic failure, Patient having neuropsychiatric disease, Patient allergy to the study drugs

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group A<br>Patients with NLR level below 2 | Diagnostic Test: Neutrophil Lynphosite ratio<br>* The patients were divided into 2 groups as NLR level above 2 (Group A) (n:32) and NLR level below 2 (Group B) (n:28).<br>|
| Group B<br>Patients with NLR level equal to or above 2 | Diagnostic Test: Neutrophil Lynphosite ratio<br>* The patients were divided into 2 groups as NLR level above 2 (Group A) (n:32) and NLR level below 2 (Group B) (n:28).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| preoperative neutrophil lymphoycte ratio | To determine the epidural application with preoperative neutrophil lymphoycte ratio | 24 hours before the operation | 
| Postoperative opioid requiremen Postoperative opioid requirement | Postoperative opioid requirement for pain relief | postoperative first 24 hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Numerical Pain Rating Scale | Numerical Pain Rating Scale in postoperative period | postoperative first 24 hour | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Preemptive Epidural Analgesia, Neutrophil/Lymphocyte Ratio, İnflammation