Interactive Stepping Exercise on Balance and Cognitive Function

Study Overview
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Brief Summary
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The objective of this study is to investigate the effects of interactive stepping exercise on balance and cognitive function in individuals with PD.

Official Title
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Effects of Interactive Stepping Exercise on Balance and Cognitive Function in Individuals With Parkinson's Disease

Conditions
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Parkinson's Disease

Intervention / Treatment
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* Other: Interactive stepping exercise
* Other: Square stepping exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Idiopathic PD Hoehn & Yahr stage between 1 to 3 Age between 50 to 85 Stable pharmacologic treatment for the last 2 weeks Ability to walk 10 meters unassisted or with assistive devices Exclusion Criteria: Other neurological disorders diagnosis than PD Receiving any neurological surgeries Any musculoskeletal disorder or cardiopulmonary disease that may influence participation in the study The Mini-Mental State Examination (MMSE) < 24 scores Participated in other exercise intervention of study in the past 3 months Colorblindness or color vision deficiency

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Interactive stepping exercise group<br>Participants will execute interactive stepping exercise 2 times per week for 8 weeks (16 sessions). | Other: Interactive stepping exercise<br>* An exercise intervention based on the principle of square stepping exercise<br>|
| Active Comparator: Square stepping exercise group<br>Participants will execute square stepping exercise 2 times per week for 8 weeks (16 sessions). | Other: Square stepping exercise<br>* Square stepping exercise<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Romberg test | To evaluate static balance ability | Change from baseline at 8 weeks and 12 weeks | 
| Sharpened Romberg test | To evaluate static balance ability | Change from baseline at 8 weeks and 12 weeks | 
| One-leg stance test | To evaluate static balance ability | Change from baseline at 8 weeks and 12 weeks | 
| Timed up and go test | To evaluate functional walking ability | Change from baseline at 8 weeks and 12 weeks | 
| Mini-Balance Evaluation Systems Test | To evaluate balance ability | Change from baseline at 8 weeks and 12 weeks | 
| Montreal Cognitive Assessment Chinese version | To evaluate global cognitive function | Change from baseline at 8 weeks and 12 weeks | 
| Digit span test | To evaluate executive function | Change from baseline at 8 weeks and 12 weeks | 
| Stroop color and word test Chinese version | To evaluate executive function | Change from baseline at 8 weeks and 12 weeks | 
| Trail-making test Chinese version | To evaluate executive function | Change from baseline at 8 weeks and 12 weeks | 
| Spatial span test | To evaluate visuospatial ability | Change from baseline at 8 weeks and 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 10-meter walk test | To evaluate walking ability | Change from baseline at 8 weeks and 12 weeks | 
| Parkinson's Disease Questionnaire 39 | To evaluate the quality of life | Change from baseline at 8 weeks and 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Balance ability, Interactive stepping exercise, Square stepping exercise, Parkinson's disease, Cognitive function