Hybrid Training and Middle Age

Study Overview
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Brief Summary
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Modern living and physical inactivity results in many ailments, including obesity, non-alcoholic fatty liver disease (NAFLD), and inflammatory issues. Though there are a lot of studies on physical training, there is little detail on hybrid training or electrical and voluntary contractions of the musculature. This study investigated the efficiency of hybrid training in biochemistry, ultrasound, and proinflammatory outcomes in middle-aged sedentary and obese women with NAFLD.

Official Title
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Study of Hybrid Training on Lipid Profile and Non-alcoholic Fatty Liver Disease in Middle-aged Obese Women

Conditions
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Women's Health, Hybrid Training, Middle Aged, Non-alcoholic Fatty Liver Disease, Metabolic Syndrome

Intervention / Treatment
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* Other: hybrid training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Sedentary women with one to two exercise sessions or less per month BMI equal to or above 30 kg/m-2 WHR equal or above 0.85 m Confirmed NAFLD, with grade 2 and 3 Systolic blood pressure not less than 130 mm Hg and diastolic blood pressure not less than 85 mm Hg Increased AST and ALT Mean age 45-65 years Exclusion Criteria: Use of 140 grams or more of ethanol per week History of depression in the last 6 months History of chronic or acute viral hepatitis Drug-related liver disease and chronic liver disease History of diabetes Uncontrolled hypertension Myocardial infarction Chronic kidney disease Hyperthyroidism or heart failure Those who have weight loss programs or medical contraindications for physical training Serious arterial hemorrhagic disorders Serious neurological diseases Advanced atherosclerosis Elevated fever

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Hybrid training<br>15 women for hybrid training. | Other: hybrid training<br>* The experimental group trained two to three sessions of 45 to 50 minutes a week with a recovery of 24 to 48 hours between each session to burn 500 kcal. The first three weeks held hybrid training with a metabolic program and the other three weeks held a strength training program.<br>|
| No Intervention: Healthy lifestyle counseling<br>15 women for healthy lifestyle counseling | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body Weight | in kg | Pre-study | 
| Body Mass Index | in kg/m-2 | Pre-study | 
| Aspartate transaminases | in u/l | Pre-study | 
| Alanine transaminases | in u/l | Pre-study | 
| Fasting blood sugar | in mg/dl | Pre-study | 
| Proinflammatory cytokine (interleukin -6) | in pg/ml | Pre-study | 
| Ultrasonic assessment | Grade of liver steatosis | Pre-study | 
| WHR | Waist-to-hip ratio in cm | Pre-study | 
| SBP/DBP | Systolic blood pressure/Diastolic blood pressure | Pre-study | 
| HDL Cholesterol Plasma | in mg/dl | Pre-study | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body Weight | in kg | six-week | 
| Body Mass Index | in kg/m-2 | six-week | 
| Aspartate transaminases | in u/l | six-week | 
| Alanine transaminases | in u/l | six-week | 
| Fasting blood sugar | in mg/dl | six-week | 
| Proinflammatory cytokine (interleukin -6) | in pg/ml | six-week | 
| Ultrasonic assessment | Grade of liver steatosis | six-week | 
| WHR | Waist-to-hip ratio in cm | six-week | 
| SBP/DBP | Systolic blood pressure/Diastolic blood pressure | six-week | 
| HDL Cholesterol Plasma | in mg/dl | six-week |