Digital Wavefront Sensing

Study Overview
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Brief Summary
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A holographic optical coherence tomography (H-OCT) setup is used to detect the wavefront by means of phase reconstruction.

Detailed Description
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H-OCT will be tested in this study for its suitability for the qualitative investigation of aberrometry. We aim to achieve a digital equivalent for wavefront calculation of the widespread analog procedure commonly used with conventional wavefront-aberrometers. The results will be compared with those from a conventional analog wavefront calculation method. In the course of this pilot study, 20 eyes of phakic and 10 eyes of pseudophakic subjects with suspected higher order aberrations will be examined using H-OCT.

Official Title
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Reproducibility and Comparison of Digital Wavefront Sensing With Conventional Shack-Hartmann Wavefront Sensing: an Explorative Study

Conditions
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Wavefront Aberration, Corneal, Refractive Errors

Intervention / Treatment
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* Device: Holographic optical coherence tomography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Informed consent Men and women aged between 18 and 85 years Normal ophthalmic findings except refractive errors or suspected higher order aberrations Normal findings in the medical history unless the investigator considers an abnormality to be clinically irrelevant Exclusion Criteria: Hyperopia > +6 Dpt. and Myopia < -6 Dpt. Known ophthalmic diseases such as age related macular degeneration, diabetic retinopathy, glaucoma, retinal detachment or previous ocular trauma and surgeries except cataract extraction Participation in a clinical trial in the previous 3 weeks Presence of any abnormalities preventing reliable measurements as judged by the investigator Pregnancy, planned pregnancy or lactating

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Holographic optical coherence tomography<br>Healthy phakic participants | Device: Holographic optical coherence tomography<br>* Descriptive wavefront analysis with holographic optical coherence tomography<br>* Other names: Digital aberrometry;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Qualitative description of lower order aberrations (LOA) | Zernike terms, RMS-error, Strehl ratio | 14 +/- 3 days | 
| Qualitative description of higher order aberrations (HOA) | Zernike terms, root mean square error , Strehl ratio | 14 +/- 3 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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digital wavefront sensing, optical coherence tomography