linjc16/ctgov huggingface dataset:
Internal Jugular Vein Distensibility to Predict Fluid Responsiveness in Patients After Cardiac Surgery

Study Overview
=================
Brief Summary
-----------------
The purpose of the study was to verify the efficacy of using internal jugular vein (IJV) size and distensibility as an index of fluid responsiveness in mechanically ventilated patients after cardiac surgery.

Conditions
-----------------
Cardiac Surgery

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: hypotension oliguria high lactate level Exclusion Criteria: cardiac arrhythmia clinically relevant tricuspid or mitral regurgitation, clinically relevant right heart failure thrombosis in any large upper body veins bilaterally inserted venous catheters

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| fluid responders<br>Patients whose stroke volume index increase by >10% in response to a 500-ml fluid bolus was defined as fluid responders. | |
| fluid non-responders<br>Patients whose stroke volume index increase by <10% in response to a 500-ml fluid bolus was defined as fluid non-responders. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| fluid responsiveness （mean artery pressure、cardiac output、stroke volume variation、internal jugular vein distensibility） | CO increased more than 10% was defined as fluid responsiveness | after fluid challenge (30min) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
internal jugular vein distensibility,haemodynamics
Measuring Surgical Recovery After Radical Cystectomy

Study Overview
=================
Brief Summary
-----------------
The intent of this study is to establish a registry of post-surgical outcomes in patients undergoing radical cystectomy at MD Anderson Cancer Center and the collaborating institutions. The goals of this initiative are to obtain a detailed baseline of multiple patient-reported outcomes (PRO) and clinician-reported outcomes (CRO) as well as various presenting conditions associated with them, so that future quality improvement interventions can be evaluated accurately as to their relative contribution to improved outcomes.

Official Title
-----------------
Measuring Surgical Recovery After Radical Cystectomy

Conditions
-----------------
Bladder Cancer

Intervention / Treatment
-----------------
* Behavioral: Post-Operative Recovery Registry


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1. Bladder cancer patients undergoing radical cystectomy at the MD Anderson Cancer Center and the collaborating centers. Exclusion Criteria: N/A

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Bladder Cancer Patients Undergoing Radical Cystectomy<br>Prospective registry of bladder cancer patients undergoing radical cystectomy at MD Anderson Cancer Center and the collaborating centers. | Behavioral: Post-Operative Recovery Registry<br>* Multi-institutional prospective database of patients with bladder cancer undergoing radical cystectomy.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Post-Surgical Outcomes in Patients Undergoing Radical Cystectomy | Post-surgical outcomes determined from patient-reported assessment of symptom burden using the MD Anderson Symptom Inventory (MDASI-BLC form). | 3 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Bladder Cancer, Registry, Post-surgical outcomes, Radical cystectomy, MD Anderson Symptom inventory, MDASI
Foldable Capsular Vitreous Body Implantation Study

Study Overview
=================
Brief Summary
-----------------
This study is intended to evaluate the clinical usefulness of the FCVB in its on-label use, but in a different racial type than studies till now (Asians only). The device will be inserted in Caucasian patients with permanent loss of functional vision (visual acuity hand movements or less), where a permanent use of repeat silicone oil is required to maintain the eye pressure.

Official Title
-----------------
Foldable Capsular Vitreous Body Implantation Study

Conditions
-----------------
Vitreoretinal Surgery

Intervention / Treatment
-----------------
* Device: Foldable Capsular Vitreous Body Implant


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients aged over 18 Axial length between 16 and 28 mm (according the guidelines from the manufacturer) Loss of functional vision in study eye Visual acuity of 0.4 or better in fellow eye Requirement of (repeated) long-term silicone oil tamponade to maintain eye pressure and keep the retina attached Exclusion Criteria: Visual acuity beyond 0.4 in non-study eye Severe general disease that is evaluated to impact live expectancy beyond the duration of the study follow-up (3 years) Retinal detachment under silicone oil fill Patients with a silica gel allergy or scar diathesis Patients with serious heart, lung, liver, or kidney dysfunction Patients with proliferative diabetic retinopathy, endophthalmia, uveitis and other uncontrollable eye diseases, or a contralateral eye that had intraocular retinal surgery Patients with history of drug abuse or alcoholism Patients are had participating in other drug or medical device clinical trials before screening for this trial Pregnancy, preparation for pregnancy during clinical trial, or breast-feeding Belief by any of the research doctors that a patient's condition would hinder the clinical trial, such as a patient prone to mental stress, loss of control of mood, or depression

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: FCVB Implant<br>All subjects in this study are in the experimental treatment arm and will receive the FCVB implant | Device: Foldable Capsular Vitreous Body Implant<br>* Vitrectomy augmented with the implantation of the FCVB implant<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intra-ocular pressure | Evaluation of the device as long-term solution for maintenance the intra-ocular pressure, potentially reducing the number of surgeries (silicone oil exchanges) for the patient | 3 years |
Ozone Autohemotherapy for Ischemic Stroke Sleep Disorder

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to observe the efficacy and safety of ozonated autohemotherapy in patients of post-ischemic stroke insomnia and to explore its mechanism of action.

Official Title
-----------------
Effects of Ozone Autohemotherapy on Patients With Post-ischemic Stroke Insomnia

Conditions
-----------------
Post-ischemic Stroke Insomnia

Intervention / Treatment
-----------------
* Other: ozone autohemotherapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: meet the diagnostic criteria for ischemic stroke; Insomnia quality index (ISI) score > 7 points Exclusion Criteria: acute ischemic stroke; associated with failure of important organs or malignant tumor; patients with worsening condition, new cerebral infarction or secondary cerebral hemorrhage; with comprehension or cognitive impairment, unable to fully understand the scale and unable to cooperate with treatment
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control<br>No intervention was given to this group of patients | |
| Experimental: 20-40ug/ml ozone<br>ozone autohemotherapy | Other: ozone autohemotherapy<br>* After autologous blood is mixed with ozone in vitro, the blood is injected into the patient through intravenous infusion<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Insomnia severity index | The Insomnia Severity Index Scale (ISI) will be used, which scale ranges from 0 to 28, with higher scores representing more severe insomnia. Specifically, 0-5 points represent excellent sleep quality, 6-10 points mean good sleep quality, 11-15 points indicate average sleep quality, and 16-21 points represent poor sleep quality. | 2 weeks | 
| Pittsburgh Sleep Quality Index | The Pittsburgh Sleep Quality Index Scale (PSQI) will be used, which scale ranges from 0 to 21, with higher scores representing poorer sleep quality. In detail, 0-7 points represent insomnia of no clinical significance, 8-14 points mean sub-clinical insomnia, 15-21 points indicate moderate clinical insomnia, and 22-28 points represent severe clinical insomnia. | 2 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| brain-derived neurotrophic factor (BDNF) | Detection of BDNF in serum of patients using Elisa kit | 2 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Ischemic stroke, Insomnia, Ozone Autohemotherapy
Observing Changes in Ventilation Pattern During Procedural Sedation

Study Overview
=================
Brief Summary
-----------------
The ventilation (respiratory rate, tidal volume and end-tidal CO2) was monitored for patients receiving procedural sedation during endoscopy procedures in order to observe what changes commonly occur.

Detailed Description
-----------------
The literature does not currently describe which ventilation changes a clinician should watch for to keep a patient safe during procedural sedation provided by fentanyl and propofol. This observational study aimed to record the breath-by-breath respiratory rate, tidal volume and end-tidal CO2 for each patient during procedural sedation for each endoscopy procedure. Data analysis offline will aim to identify any patterns in ventilation which may precede apnea or blood oxygen desaturation. The patterns in ventilation preceding apnea or blood oxygen saturation will be compared and contrasted with the patterns of ventilation during normal ventilation periods.

Official Title
-----------------
Observing Changes in Ventilation Pattern During Procedural Sedation

Conditions
-----------------
Pulmonary Ventilation

Intervention / Treatment
-----------------
* Other: No intervention, only ventilation monitoring


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: (i) ASA I, II, or III (ii) patients older than eighteen (iii) English speaking (iv) undergoing a colonoscopy procedure and receiving procedural sedation Exclusion Criteria: (i) inability/refusal of subject to provide informed consent (ii) standard colonoscopy exclusion criteria used at the GI lab at the University of Utah (iii) patients with severe medical conditions that in the view of the acting physician prohibits participation in the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients receiving procedural sedation<br>The investigators collected ventilation data for each breath (respiratory rate, tidal volume, and end-tidal CO2) for all patients receiving procedural sedation for endoscopy. | Other: No intervention, only ventilation monitoring<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Respiratory rate |  | Measured for every breath observed throughout the endoscopy procedure | 
| Tidal volume |  | Measured for every breath observed throughout the endoscopy procedure | 
| End-tidal CO2 |  | Measured for every breath observed throughout the endoscopy procedure |
The Influence of Education of Medical Team on Duration of Fasting Before Elective Medical Interventions Performed Under General Anesthesia in Children

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to examine if an education program of the medical teams can help implementation of of NPO (nothing-per-os)orders in children before anesthesia for ambulatory medical interventions under anesthesia and decrease unnecessary long fasting. We shall ask parents of such children to fill in a questionnaire regarding pre-anesthesia fasting and regular eating and drinking habits. Thereafter, all medical teams involved with the administration of NPO orders will receive an educational program to explain and implement the NPO orders as are recommended by the American Society of Anesthesiologists. We will examine if the educational program was successful in reducing unnecessary long period of fasting, and if such a program is not associated with increased rate of delay of cases.

Official Title
-----------------
The Influence of Education of Medical Team on Duration of Fasting Before Elective Medical Interventions Performed Under General Anesthesia in Children

Conditions
-----------------
Duration of Preoperative Fasting

Intervention / Treatment
-----------------
* Other: education


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children who are about to undergo anesthesia for elective medical interventions, Age 0-18 years

Ages Eligible for Study
-----------------
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: education|The intervention is an education of the medical teams that instruct children to fast before the administration of general anesthesia|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Education of the medical teams as to preoperative fasting time will aid in shortening of an unnecessary prolonged fasting |  | Immediate pre-anesthesia period (to assess lenth ofpreoperative fasting time) |
Estimation of Cardiac Output in Neonatal ICU Using an Ultrasound Dilution Technique

Study Overview
=================
Brief Summary
-----------------
Presently there is no apparatus, clinically available, for routine determination of cardiac output (CO) in children. The goal of this research is to develop new technology that will help determine CO in neonates.

Official Title
-----------------
Estimation of Cardiac Output in Neonatal ICU Using an Ultrasound Dilution Technique

Conditions
-----------------
Neonatal Intensive Care

Intervention / Treatment
-----------------
* Device: COstatus cardiac output measurement with isotonic saline


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All neonatal patients cared for in our ICU with umbilical venous and arterial catheters simultaneously in place for their care, will be eligible. Exclusion Criteria: Patients would be excluded if the family/guardian denied permission or if the attending physician felt the patient was not stable.

Ages Eligible for Study
-----------------
Maximum Age: 1 Month

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: COstatus cardiac output measurement with isotonic saline|Isotonic saline, which is the indicator, is injected to obtain COstatus cardiac output measurements. No other interventions are made for the purpose of the study.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cardiac Output, Blood volumes, Neonates
Influence of Beta Blockers on Prognosis in Patients With Acute Myocardial Infarction Complicated With Normal Ejection Fraction

Study Overview
=================
Brief Summary
-----------------
To understand the effect of beta blockers on the prognosis of patients with acute myocardial infarction with preserved ejection fraction.

Detailed Description
-----------------
The use of beta blockers is an important component of drug therapy for myocardial infarction, but in some exceptional cases, evidence-based evidence for their use is insufficient, and we seek to understand the prognostic impact of beta blockers on patients enrolled in long-term follow-up.

Official Title
-----------------
Influence of Beta Blockers on Prognosis in Patients With Acute Myocardial Infarction Complicated With Normal Ejection Fraction

Conditions
-----------------
AMI

Intervention / Treatment
-----------------
* Drug: Beta blocker


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with acute myocardial infarction Exclusion Criteria: Previous history of heart failure admission Killip class > I class cancer pregnant

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No-beta blocker<br> | |
| beta blocker<br> | Drug: Beta blocker<br>* Duration of medication<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Death | all-cause mortality | The median time of 3 years |
Opioid Agonist and Antagonist Effects on Opioid Dependence

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to examine the acute agonist and antagonist effects of a full opioid agonist medication, an opioid antagonist medication, and a partial opioid agonist medication in individuals who have different levels of physical opioid dependence.

Detailed Description
-----------------
The pharmacological effects of opioids in opioid dependent individuals can vary as a function of the characteristics of the opioid being studied (e.g., whether it is an agonist, partial agonist, or antagonist; the dose administered; and the route of administration). Another important set of factors influencing the effects produced by opioids is the characteristics of the organism to which the opioid is being administered. One such characteristic is the level of physical dependence in individuals. Participants in this study will be maintained on different dose levels of an opioid agonist (methadone). The participant will be challenged with a prototypic opioid agonist, antagonist, and a mixed agonist-antagonist with partial agonist features in order to determine the effects that each has on the human body.

Official Title
-----------------
The Variability of Agonist and Antagonist Effects as a Function of Level of Physical Dependence

Conditions
-----------------
Opioid-Related Disorders

Intervention / Treatment
-----------------
* Drug: Methadone
* Drug: Full opioid agonist
* Drug: Partial opioid agonist
* Drug: Opioid antagonist


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Active opioid dependence Qualifies for opioid agonist treatment (e.g., methadone or buprenorphine) Fulfills DSM-IV diagnostic criteria for opioid dependence Exclusion Criteria: Significant medical problems, including insulin dependent diabetes mellitus Non-substance use psychiatric disorders (e.g., schizophrenia) Currently seeking treatment for substance abuse

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Methadone|nan|
|Drug: Full opioid agonist|nan|
|Drug: Partial opioid agonist|nan|
|Drug: Opioid antagonist|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Opiate withdrawal |  | up to one day | 
| Opiate agonist symptoms |  | up to one day | 
| Physiologic measures |  | up to one day |