Effects of Position and a Test Meal on Esophago-gastric Junction Morphology and Function Assessed by High-resolution Impedance Manometry (HRM)

Study Overview
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Brief Summary
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Retrospective analysis for HRM measurements using liquid swallows and a test meal for the presence of hiatal hernia. The investigators will correlate hernia descriptions with presence of acidic reflux and clinical complaints.

Detailed Description
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We will retrospectively analyze all patients referred to hour unit for high-resolution esophageal manometry. These patients have been tested using liquid swallows and a test meal. We will analyze the HRM measurements for presence of manometric signs of hiatal hernia and determine predictive factors for hernia presence. We will correlate hernia description versus presence of acid reflux, clinical complaints and HRM measurements.

Official Title
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Effects of Position and a Test Meal on Esophago-gastric Junction Morphology and Function Assessed by High-resolution Impedance Manometry (HRM)

Conditions
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Hiatus Hernia

Intervention / Treatment
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* Other: high resolution esophageal manometry


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients referred to our functional lab for esophageal high-resolution manometry from January 2013 - December 20165 Lack of documentation of patient preferences against usage of medical data for biomedical research Male and female patients ≥18 years of age Exclusion Criteria: Age under 18 years Patient's wishes against scientific use of their clinical data

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: high resolution esophageal manometry|high resolution esophageal manometry using liquid and solid swallows and a test meal.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effects of hernia type (consistent hernia, transient hernia and no hernia, as specified bellow) on reflux symptoms |  | 1 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differences in hernia size between sitting and recumbent position as well as between liquid swallows, free drinking and test meal. |  | 1 hour | 
| Diagnostic accuracy for hernia diagnosis by HRM for sitting, and recumbent position, free drinking and test meal. |  | 1 hour | 
| Correlation of pH-impedance measurements (if available) with manometric and clinical data. |  | 1 hour | 
| Correlation of various measurements describing esophageal motility according to Chicago classification with type of hernia, clinical symptoms and pH-impedance measurements |  | 1 hour | 
| Correlation of hernia diagnosis and hernia size according to imaging exams (if available: CT scan, fluoroscopy) and endoscopy (if available) with hernia diagnosis by HRM |  | 1 hour | 
| Correlation of body measurements (body mass index, BMI, waist circumference) of patients with type of hernia, clinical symptoms and pH-impedance measurements |  | 1 hour | 
| Correlation of visceral sensitivity (determined by balloon inflation) with reflux symptoms |  | 1 hour | 
| Prediction of reflux symptoms using a model including hernia and esophageal peristalsis characteristics, visceral sensitivity (balloon inflation) and anthropometric measurements |  | 1 hour |