linjc16/ctgov huggingface dataset:
Host Response to Urinary Tract Infection in Women

Study Overview
=================
Brief Summary
-----------------
This study is being done to identify those elements of the immune response that may predispose a woman to recurrent urinary tract infection. We suspect that lesser effectiveness of certain components of the host response will lead to recurrent urinary tract infection. We will also evaluate the role that the bladder reservoir may play in recurrent urinary tract infection.

Detailed Description
-----------------
Procedures subjects will undergo once they have read and signed the consent are: Questions about their medical and sexual history and current symptoms of urinary tract infection. They will be asked to provide a clean catch urine sample. We will collect periurethral, vaginal and rectal swabs. Blood will collected. They will be given a diary to take home and record all episodes of sexual intercourse, contraceptive use, vaginal and urinary symptoms and medication use. They will be given standard treatment for the current urinary tract infection. Follow-up visits will be scheduled 2 weeks,one month,two month and three month after initial visit.

Official Title
-----------------
Host Response to Urinary Tract Infection in Women

Conditions
-----------------
Urinary Tract Infection

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Female Age 18-49 years Able to provide written informed consent diagnosis of acute cystitis with symptoms for fewer than 7 days Exclusion Criteria: Not pregnant or planning pregnancy in next 3 months No chronic illness requiring medical supervision (e.g. diabetes mellitus) No known anatomic or functional abnormalities of the urinary tract No signs or symptoms suggestive of pyelonephritis (flank pain or tenderness, temperature over 100 degrees F, nausea or vomiting)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 49 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Host<br>Women with current symptoms of a urinary tract infection | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determine elements of the immune response that may predispose a woman to recurrent urinary tract infection |  | 2017 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Current symptoms of urinary tract infection
Trial of a Nurse Led Hypertension Clinic in Inner City General Practices

Study Overview
=================
Brief Summary
-----------------
The investigators will do a trial in two general practices to see if the introduction of a blood pressure clinic staffed by a specialist nurse supported by visiting consultant improves blood pressure control compared to usual care.

Official Title
-----------------
Evaluation of a Nurse-led Hypertension Clinic in Two Inner City General Practices: Randomised Controlled Trial

Conditions
-----------------
Hypertension

Intervention / Treatment
-----------------
* Other: Nurse-led blood pressure clinic


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with last recorded blood pressure greater or equal to the British Hypertension Society audit standard Exclusion Criteria: Secondary hypertension Housebound Non-English speaking Another major illness likely to dominate pattern of care e.g. advanced cancer, dementia

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Usual care<br>Patients not invited to the nurse-led clinic will continue with usual GP care | |
| Experimental: Nurse-led blood pressure clinic<br>Patients randomly allocated to the intervention will be invited to a specialist nurse-led blood pressure clinic. | Other: Nurse-led blood pressure clinic<br>* Blood pressure will be measured according to protocol.For patients with blood pressure above optimal targets, treatment changes will be discussed with the patient, a visiting consultant physician and the patient's GP. If they agree, the GP will intensify anti-hypertensive treatment with monthly follow up by the specialist nurse until BP targets are achieved.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in systolic blood pressure | This will be assessed using two audits of practice records where blood pressure was measured and recorded independently by practice staff | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of patients in each group with final blood pressure below the British Hypertension Society optimal target |  | 6 months after recruitment | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hypertension, clinical trial, nurse-led clinic, primary care
The Relationship Between Covid-19 Infection in Pediatric Patients and Secondary Lymphoid Organs

Study Overview
=================
Brief Summary
-----------------
We aimed to find out whether the tonsils and nasal tissues of pediatric patients are the main factors that protects the children's immune system against COVID-19 infection.

Detailed Description
-----------------
Since it is known that the tonsil and adenoid tissues that are known as a secondary lymphoid organ, which form the first line of defense, are more active in childhood than adults, especially in the childhood age group, and since it has been scientifically shown that patients diagnosed with COVID-19 infection in the pediatric age group overcome this disease lightly than adults, we aimed to reveal whether the defined tonsil and adenoid tissues are the main factors that protect the children's immune system against COVID-19 infection.

Official Title
-----------------
The Relationship Between Mild Covid-19 Infection in Pediatric Patients and Protection of Secondary Lymphoid Organs

Conditions
-----------------
Covid19, Immune Deficiency, Tonsillitis, Tonsil Hypertrophy, Adenoiditis, Adenoid Hypertrophy

Intervention / Treatment
-----------------
* Diagnostic Test: Physical examination


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with COVID-19 infection. Patients aged between 1-16 years Patients whose PCR test becomes negative Exclusion Criteria: Patients with lymphoid tissue malignant disease Patients with known lung disease Patients with known systemic disease

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Physical examination|Pediatric patients diagnosed with COVID-19 and who have had infection will be examined, adenoid and tonsillar tissues will be evaluated in terms of hypertrophy, chronic, or recurrent infection.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The primary outcome of our study was the evaluation of pediatric patients diagnosed with COVID-19 and who had COVID-19 infection in terms of adenoid and tonsillar tissue hypertrophy and the presence of chronic or recurrent infection. | The structure of the tonsil and adenoid tissues will be examined by physical examination, and the presence of tonsil and adenoid hypertrophy, tonsillitis, and adenoiditis conditions will be identified. The severity of covid-19 will be determined according to the cases of patients with tonsil and adenoid tissue disorders, who are hospitalized in intensive care, have infiltration in the lungs, and receive oxygen support. | 2020-2021 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
pediatric, covid19, İmmune system
Insulin Infusion in the Hospital Wards

Study Overview
=================
Brief Summary
-----------------
Increasing evidence from clinical studies in Intensive Care Unit (ICU) settings indicates that insulin infusion can improve outcome measures for patients with hyperglycemia (high blood sugar) independent of a previous diagnosis of diabetes mellitus. This improvement in health could also apply to patients that have high blood sugars in various other non-critical care areas of the hospital as well. However, the data that shows improvement in health outcomes has been collected from wards that have a lower patient to provider and patient to nurse ratio, resulting in the ability for a much tighter control of the insulin infusion. We hypothesize that tight blood glucose control will provide the same benefits for patients in non-intensive care units settings but that these protocols may lead to a higher incidence of hypoglycemia (low blood sugar) and potentially to adverse outcomes in patients. This study aims to determine the clinical outcome of patients treated with insulin infusion as well as the rate of hypoglycemic episodes in non-intensive areas. We will conduct a chart review of patients treated with insulin infusions in non-critical wards at Emory University Hospital during the period of 7/1/04 to 6/30/05. Medical records of all patients treated with intravenous insulin infusion protocols will be analyzed. Data on demographics, laboratory values, mortality rate, rate of hypoglycemic events, length of stay, as well as disposition at discharge will be analyzed.

Official Title
-----------------
Insulin Infusion and Outcomes for Non-Critical Wards

Conditions
-----------------
Hyperglycemia

Intervention / Treatment
-----------------
* Drug: Insulin Drip Therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All subjects over 18 years of age that received intravenous insulin treatment on general medical and surgical wards at Emory University Hospital during the period of 7/1/2004 to 6/30/2005

Ages Eligible for Study
-----------------
Minimum Age: 19 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Insulin Drip Therapy|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
hyperglycemia, diabetes, insulin drip, hypoglycemia, general wards
The Effect of a Multimodal Lifestyle Program on Male Fertility

Study Overview
=================
Brief Summary
-----------------
A non-pharmacological study, which examines the effect of lifestyle intervention on sperm quality among men in fertility treatment. The primary endpoint is to increase the total amount of motile sperm in male patients undergoing fertility treatment

Official Title
-----------------
Evaluation of the Effect of a Multimodal Lifestyle Program on Semen Quality and DNA Fragmentation in Male Patients Attending Fertility Treatment

Conditions
-----------------
Infertility, Male

Intervention / Treatment
-----------------
* Dietary Supplement: Lifestyle


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Men of couples who are about to start 2nd or 3rd fertility treatment > 18 years old Sperm concentration between 2-40 mill./ml Exclusion Criteria: Use of testicular sperm

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention<br>Lifestyle intervention i.e. diet, exercise, smoking cessation, alcohol limitations, dietary supplementation | Dietary Supplement: Lifestyle<br>* Lifestyle intervention i.e. diet, exercise, smoking cessation, alcohol limitations, dietary supplementation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Increase in the total amount of motil sperm in male patients undergoing fertility treatment | Change in classical sperm parameters | 90 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in DNA fragmentation index (DFI) | DFI is measured by Comet Assay | 90 days | 
| Changes in parameters for metabolic syndrome | Weight in kilograms | 90 days | 
| Changes in parameters for metabolic syndrome | BMI (Body Mass Index). Weight and height will be combined to report BMI in kg/m^2 | 90 days | 
| Changes in parameters for metabolic syndrome | Blood pressure in millimeters of mercury | 90 days | 
| Change in plasma lipids | Plasma lipids i.e. Total cholesterol, high density lipoprotein, low density lipoprotein and triglycerides | 90 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Male infertility, Semen quality, Lifestyle intervention
Comparison of Two Radial Head Implants

Study Overview
=================
Brief Summary
-----------------
In severe injuries of the radial head with multiple, displaced fracture fragments and concomitant ligament damage, excision of the fragments and replacement of the radial head with a metallic implant are indicated. Current radial head implants are composed of metal or a combination of metal and high molecular weight polyethylene. The prostheses are assembled intra-operatively as a solid unit (monopolar) or as an articulating implant with motion between the stem and head (bi-polar). The stem of the implant is inserted into the proximal radius for support and can be classified as either loose-fitting or fixed. According to the investigators, there are no studies that directly compare the clinical and radiographic outcomes between different radial head implant designs. The purpose of this retrospective study is to compare the clinical and radiographic results in patients treated for an irreparable radial head fracture with either a smooth stem, bipolar radial head implant or a monopolar, in-growth radial head implant. The study findings may provide useful clinical information regarding the similarities and differences in these two implant designs.

Detailed Description
-----------------
Data has been completed.

Official Title
-----------------
Comparison of Monopolar In-Growth and Loose Bipolar Radial Head Implants in the Treatment of Irreparable Radial Head Fractures

Conditions
-----------------
Radial Head Fractures

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Suffered radial head fracture requiring radial head replacement with the Katalyst or Acumed Radial Head Implant from 2002-2009 Exclusion Criteria: Unwilling to provide informed consent Traumatic brain injury that occurred at the time of elbow fracture

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disability of Arm, Shoulder, and Hand (DASH) |  | 1 clinic visit |
Acceptability and Feasibility of Finger Foods

Study Overview
=================
Brief Summary
-----------------
This study will investigate the feasibility of using a finger food menu on an acute stroke rehabilitation ward. This study has a mixed methods design, with quantitative, qualitative and economic components which will be used to inform a future randomised control trial.

Official Title
-----------------
A Mixed Methods Study to Determine the Acceptability and Feasibility of Providing Finger Foods as Nutritional Support for Patients After Stroke in Hospital

Conditions
-----------------
Stroke, Acute

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Current patient on stroke rehabilitation ward 65 years or older Normal textured food Exclusion Criteria: On the end of life pathway Partial or full enteral feeding Significant food allergies, intolerances or other dietary restrictions that could not be catered for by the finger food menu. Unable to give consent or no consultee able to consent on behalf of patient In a side room on the ward

Ages Eligible for Study
-----------------
Minimum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Eligibility rate | Number of patients eligible for study based on inclusion and exclusion criteria | 6 months | 
| Recruitment rate | Number of patients approached vs number of patients recruited to the study | 6 months | 
| Attrition rate | Number of participants without fully completed outcome measures | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dietary intake of participants over 3 mealtimes | Estimation of dietary intake over 3 mealtimes. This will include a standard mealtime and 2 meals when the finger menu is offered. This will be measured as energy and protein intake. | 3 mealtimes | 
| Costs of implementing a finger food menu | A cost consequence analysis will be used to describe direct and indirect costs associated with providing a finger food menu. | 6 months | 
| Fidelity of intervention | Fidelity determined through observation field notes | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Finger food
Does Repetitive Electroconvulsive Therapies Affect Propofol Induction Dose ?

Study Overview
=================
Brief Summary
-----------------
Electroconvulsive therapy has been used for many years for different types of physiatric diseases. General anesthesia is used during the procedure. Different anesthesiologists use different regimens. The duration of seizure is important in this procedure. The investigators evaluated the relationship between the dose of propofol and the number of electroconvulsive therapy and duration of the seizure.

Official Title
-----------------
Does Repetitive Electroconvulsive Therapies Affect Propofol Induction Dose?

Conditions
-----------------
Physiatrics, Electroconvulsive Therapy

Intervention / Treatment
-----------------
* Drug: propofol


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients required electroconvulsive therapy for the physiatric disease Exclusion Criteria: Patients refusal

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: propofol<br>dose of propofol according to the number of therapies | Drug: propofol<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| dose of propofol |  | 10 seconds | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| duration of seizure |  | 10 seconds | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
propofol, electroconvulsive therapy, anesthesia
CCU Wireless Vital Signs Monitoring

Study Overview
=================
Brief Summary
-----------------
This is a pilot study is to test a wireless, skin-sensor device against current technology in the CCU to monitor vitals

Detailed Description
-----------------
This is a single center, prospective, observational study that will recruit subjects from Lurie Children's Hospital to test a wireless vitals monitor against the current vitals monitors used in the Cardiac Care Unit.

Official Title
-----------------
Advanced Wireless and Wearable Sensors for Patients With Critical Neonatal and Pediatric Congenital Heart Defects

Conditions
-----------------
CCU Inpatients

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients under the age of eighteen admitted to the Lurie's Children's Cardiac Care Unit will be eligible to participate Exclusion Criteria: Patients at imminent risk of death Patients with a skin abnormality that precludes assessment Patients with hyperbilirubinemia and requiring a need for UV light

Ages Eligible for Study
-----------------
Minimum Age: 0 Months
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Children under 18 years of age<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percent agreement with pilot sensor and current standard of vital signs monitoring |  | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
wireless vitals, vitals monitor, cardiac