Evaluation of Different Anesthesia for Uterine Curettage

Study Overview
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Brief Summary
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Anesthesia during uterine curettage is a problem. Paracervical block is used in general for such an operation, though, the anesthetic efficacy is incomplete. Propofol is the short-lasting intravenous anesthetic administrated popularly. Sevoflurane is a new inhalational anesthetic well-known for it's easy come, easy go property. The investigators hypothesized that propofol, sevoflurane and paracervical block had different anesthetic efficacy during uterine curettage. Which one is the optimal selection for such operation needed to be evaluated.

Official Title
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Evaluation of the Anesthetic Efficacy of Propofol,Sevoflurane and Paracervical Block for Uterine Curettage

Conditions
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Uterine Curettage, Abortion, Induced

Intervention / Treatment
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* Drug: Lidocaine
* Drug: Propofol
* Drug: Sevoflurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA status I-II Performing abortion operation (medical- or surgical) Requiring painless abortion Exclusion Criteria: < 19 yrs, and >=45 yrs History of central active drugs administration Drug abuse Hypertension Diabetes Any other chronic diseases Allergy to the study drugs Habit of over-volume alcohol drinking Records of history of centrally active drug use and psychiatry Any organic disorder

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1<br>Paracervical block will be performed | Drug: Lidocaine<br>* Paracervical injection of 2% Lidocaine to block associated nociception input<br>* Other names: Lignocaine;|
| Experimental: 2<br>Propofol anesthesia will be performed | Drug: Propofol<br>* Propofol 3mg/kg will be injected intravenously; 1 mg/kg will be added additionally for incomplete anesthesia<br>* Other names: Diprivan;|
| Experimental: 3<br>Sevoflurane anesthesia will be performed | Drug: Sevoflurane<br>* Sevoflurane 8% for anesthesia induction, 2-3% as the maintenance<br>* Other names: Sevorane;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bispectral Index (BIS) value |  | 0, 5, 10, 20, 30min after anesthesia | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intraoperative awareness |  | 0, 5, 10, 20, 30min after anesthesia | 
| Vital signs |  | 0, 5, 10, 15, 20, 25, 30min after anesthesia | 
| Arterial blood gas analysis |  | 5min before operation; 1min and 5min after beginning of the operation | 
| Pain intensity |  | 0, 5, 10, 20, 30min after surgical procedures | 
| Cortisol level |  | 30min before operation; 1 and 5min during operation | 
| Side effects |  | 30min after operation | 
| Uterine bleeding |  | 0min after completion of the operation; 1 hour after the operation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Local anesthetic, Propofol, Sevoflurane