Topical Antibiotics for Prevention of Intensive Care Unit (ICU) Central Line Infections

Study Overview
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Brief Summary
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The purpose of the study is to determine if the overall central venous catheter related infection rate can be reduced by the application of Polysporin Triple Therapy ointment to the insertion site.

Detailed Description
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Previous studies in the dialysis population have found a reduction in local and system central venous catheter related infections with the application of topical antibiotics to the insertion point. One such study found a mortality benefit with Polysporin Triple Therapy ointment. We intend to determine if this preparation can reduce overall line infection rates in the ICU environment through its application at the time of line insertion and twice more the following week.

Official Title
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Pilot Study: Topical Antibiotics for Prevention of ICU Central Line Infections

Conditions
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Blood Stream Infections, Skin Diseases, Infectious

Intervention / Treatment
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* Drug: Polysporin Triple Therapy ointment
* Other: Petroleum Jelly


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: all patients admitted to the ICU requiring a central venous catheter Exclusion Criteria: previous line infection during same ICU stay CVC for hemodialysis
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Polysporin Triple Therapy<br>Polysporin Triple Therapy ointment applied to the insertion point at the time of CVC placement and twice within the first week. | Drug: Polysporin Triple Therapy ointment<br>* Polysporin Triple Therapy ointment applied to the insertion point at the time of CVC placement and twice within the first week.<br>* Other names: Polysporin Triple Therapy (gramicidin, polymixin, bacitracin);|
| Placebo Comparator: Placebo<br>Petroleum jelly | Other: Petroleum Jelly<br>* Petroleum jelly applied to the insertion point at the time of CVC placement and twice within the first week.<br>* Other names: Vaseline;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall number of line related infections (local and blood borne) |  | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of ICU stay |  | 7 months | 
| Length of hospital stay |  | 7 months | 
| Prevalence of methicillin-resistant Staphylococcus Aureus (MRSA) |  | 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Blood stream infections, Catheter related infections, Central venous catheter related infections, Line sepsis, Topical antibiotics, Bacitracin, Polymixin, Gramicidin, Polysporin Triple Therapy, Intensive care unit