Intraoperative Ultrasonographic Localization of Pulmonary Nodules in VATS

Study Overview
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Brief Summary
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This study is conducted to explore the feasibility and value of Intraoperative ultrasonographic localization of pulmonary nodules in video-assisted thoracoscopic surgery (VATS).

Detailed Description
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The study is designed as a single center prospective trial. The participating center is Department of Ultrasound, Shanghai Chest Hospital, Shanghai Jiao Tong University, China. The study is expected to enroll 200 patients. The feasibility and value of Intraoperative ultrasonographic localization of pulmonary nodules in VATS will be explored. The accuracy rate of localization will be evaluated using gray scale mode and elastography mode. Intraoperative ultrasonographic localization will be performed using an ultrasound system (HI VISON Ascendus), which is equipped with a 5-10MHz mechanical probe (EUP-OL531).

Official Title
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Intraoperative Ultrasonographic Localization of Pulmonary Nodules in Video-assisted Thoracoscopic Surgery

Conditions
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Ultrasonography

Intervention / Treatment
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* Procedure: localization group


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who are older than 18 year-old. Chest CT shows pulmonary nodule suspected to be malignant that need to undergo VATS. Patients who have good compliance and sign informed consent. Exclusion Criteria: Patient with severe asthma and pulmonary fibrosis. Refusal of participation. Severe cardiopulmonary dysfunction and other indications that can't receive VATS.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: localization group|Intraoperative ultrasonographic localization will be performed using an ultrasound system (HI VISON Ascendus), which is equipped with a 5-10MHz mechanical probe (EUP-OL531). The accuracy rate of localization will be evaluated using gray scale mode and elastography mode.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The accuracy rate of localization | The accuracy rate of localization will be evaluated using gray scale mode and elastography mode using pathology as a reference. | one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation of lesion size and localization | Whether lesion size affects localization will be explored in the study. | one year | 
| Correlation of distance between the lesion and pleura and localization | Whether distance between the lesion and pleura affects localization will be explored. | one year | 
| Time of localization | The time of intraoperative ultrasonographic localization will be recorded. | one week | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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intraoperative ultrasonographic localization, pulmonary nodules, video-assisted thoracoscopic surgery