Safety and Efficacy Analysis of an Antibody Associated With a Chemotherapy for Patients With a Triple Negative Metastatic Breast Cancer

Study Overview
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Brief Summary
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ISIdE is an European, multicentric study that aims to assess the efficacy of Sacituzumab Govitecan (SG) in locally advanced or metastatic triple-negative breast cancer where the disease has progressed despite chemotherapy or within 6 months after the end of curative treatments in order to: evaluate the treatment efficacy in less pretreated patients. identify biomarkers that could predict response or resistance to the drug. 100 patients will be included in this trial.

Detailed Description
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ISIDE is a European, multicenter, open label, single-arm phase IIIB trial that aims to include 100 patients with pathologically documented locally advanced inoperable or metastatic triple negative breast cancer (mTNBC) whose disease has progressed either on: 1st line chemotherapy with or without immune checkpoint inhibitors (ICIs) or targeted therapy (e.g. AKT inhibitor, PI3K inhibitor, PARP inhibitor) for metastatic or inoperable locally advanced breast cancer (ABC) (neo)adjuvant chemotherapy with or without immunotherapy for early TNBC or within 6 months after the end of any systemic therapy, surgery or radiotherapy with curative intent, whatever comes last. The primary objective is to to evaluate the efficacy of sacituzumab govitecan via investigator-assessed objective response rate (ORR) according to RECIST v1.1. Patient will receive SG until disease progression, unacceptable toxicity, or decision to withdraw its participation.

Official Title
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ISIdE: Open Label, Multicentric, Single-arm Phase IIIB Trial to Evaluate the Safety and Efficacy of Sacituzumab Govitecan in Triple Negative Metastatic Breast Cancer Patients With a Biomarker Analysis

Conditions
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Triple Negative Breast Cancer, Metastatic Breast Cancer

Intervention / Treatment
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* Drug: Sacituzumab govitecan


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient must have signed a written informed consent prior to any trial specific procedures; Note; When the patient is unable to write to give his written consent, a trusted person of their choice, independent from the investigator or the sponsor, can confirm in writing the patient's consent Male or female ≥ 18 years of age; Patients with pathologically documented locally advanced inoperable or metastatic triple negative breast cancer (mTNBC) whose disease has progressed either on 1st line chemotherapy +/- immune checkpoint inhibitors (ICIs) or target therapy (e.g. AKT inhibitor, PI3K inhibitor, PARP inhibitor) for metastatic or inoperable locally advanced breast cancer (ABC) or on (neo)adjuvant chemotherapy+/-immunotherapy for early TNBC or within 6 months after the end of any systemic therapy, surgery or radiotherapy with curative intent, whatever comes last. Note: TNBC is defined as the absence of HER2 overexpression by immunohistochemistry (IHC) defined as IHC 0, 1+, or 2+ and fluorescence in situ hybridization [FISH] non-amplified and estrogen receptor (ER) expression <10% and progesterone receptor (PR) expression <10% by local pathological assessment on the baseline biopsy or in a recent tissue sample collected within 1 month Prior exposure to a taxane in localized or advanced/metastatic setting; If indicated, prior therapy with ICI for patients with PD1 positive tumor and prior treatment with PARP inhibitor for patients with gBRCAm Measurable disease, as defined by RECIST v1.1 Patient must have accepted to perform pre-treatment, on-treatment and post-treatment biopsies. If the physician considers doing the biopsy on the primary tumor site because accessibility, it can be performed only if the primary tumor site has not been previously irradiated; Have metastatic site easily accessible to biopsy (with exception of bone metastasis) Note: Patients with only bone metastasis will be eligible if the primary tumor is accessible for biopsy at inclusion Eastern Cooperative Oncology Group (ECOG) performance status ≤2; Life expectancy ≥12 weeks; Adequate haematologic and organ function Negative hepatitis B surface antigen (HBsAg) test at screening (patients with a negative HBsAg test and a positive total hepatitis B core antibody (HBcAb) test at screening are eligible), negative hepatitis C virus (HCV) antibody test at screening, or positive HCV antibody test followed by a negative HCV RNA test at screening; Evidence of post-menopausal status or negative pregnancy urinary test within 72 hours or serum pregnancy test within 14 days before study treatment and confirmed prior to treatment on Cycle 1 Day 1 for female pre-menopausal patients; Woman of childbearing potential and male patient must agree to use adequate contraception for the duration of trial participation and up to 6 months after completing treatment for women and up to 3 months for men; Patient affiliated to a social security system (or equivalent); Patient is willing and able to comply with the protocol for the duration of the trial including undergoing treatment and scheduled visits, and examinations including follow-up; Exclusion Criteria: Participation in another therapeutic trial within the 30 days prior to enrolment; Symptomatic, untreated, or actively progressing central nervous system (CNS) metastases or evidence of leptomeningeal disease or clinically active spinal cord compression. Patients with stable and asymptomatic brain metastases will be eligible, yet the number will be capped to 15% of the overall population; Previous history of cancer other than mTNBC within 5 years prior to C1D1, except of those with a negligible risk of metastasis or death (e.g., 5-year OS rate >90%) and treated with curative intent (e.g. carcinoma in situ of the cervix, non-melanoma skin carcinoma, localized prostate cancer, ductal carcinoma in situ, or stage I uterine cancer); Met any of the following criteria for cardiac disease: Myocardial infarction or unstable angina pectoris within 6 months of enrolment. History of serious ventricular arrhythmia (ie, ventricular tachycardia or ventricular fibrillation), high-grade atrioventricular block, or other cardiac arrhythmias requiring antiarrhythmic medications (except for atrial fibrillation that is well controlled with antiarrhythmic medication); history of QT interval prolongation. New York Heart Association (NYHA) Class III or greater congestive heart failure or left ventricular ejection fraction of <40%. Severe uncontrolled infection requiring oral or IV antibiotics within 4 weeks prior to C1D1; Major surgical procedure within 4 weeks prior to C1D1; History of severe allergic, anaphylactic, or other hypersensitivity reactions to humanized antibodies; Known hypersensitivity to the study drug, its metabolites, or formulation excipient. Patients receiving concomitant anti-cancer treatments such as chemotherapy, immunotherapy, endocrine therapy and radiotherapy; Patients with unresolved toxicities from previous anticancer therapy, defined as toxicities (other than alopecia) not yet resolved according to the common terminology criteria for adverse events of the National Cancer Institute (NCI-CTCAE) v5.0 grade >2 Treatment with systemic corticosteroids dosed at >20 mg prednisone or equivalent or other systemic immunosuppressive medications within 2 weeks prior to C1D1; Known history of testing positive for HIV or known acquired immunodeficiency syndrome; Covid-19 infection at screening; Evidence of significant uncontrolled concomitant disease; Individuals with physical or psychological conditions considered not to be compatible with the trial; Persons deprived of their liberty or under protective custody or guardianship; Pregnant or breastfeeding women; Patients unwilling or unable to comply with the medical follow-up required by the trial because of geographic, familial, social, or psychological reasons.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Single arm receiving sacituzumab govitecan<br> | Drug: Sacituzumab govitecan<br>* Sacituzumab Govitecan (SG) is given by intervenous route, 10 mg/kg on day 1 and day 8 of 21-day treatment cycles. Patient will receive treatment until disease progression, unacceptable toxicity, or decision to withdraw its participation.<br>* Other names: trodelvy;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Objective response rate (ORR) | ORR is defined as the number of patient with at least a confirmed complete response (CR) or partial response (PR), based on the best objective response values while on treatment | From inclusion to disease progression, up to 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression-free survival (PFS) | PFS iis the length of time during and after the treatment of a disease that a patient lives with the disease but it does not get worse. | From inclusion to disease progression or death, up to 2 years | 
| Duration of response (DOR) | DOR is defined as the time from the date of the first documentation of objective response (CR or PR) to the date of the first documentation of disease progression or death due to any cause | From inclusion to disease progression or death, up to 2 years | 
| Clinical benefice risk (CBR) | CBR is defined as the presence of at least a PR or CR, or a stable disease (SD) while on treatment | From inclusion to disease progression or death, up to 2 years | 
| Overall Survival (OS) | The overall survival is the length of time from randomization that patients enrolled in the study are still alive. | From inclusion to disease progression or death, up to 2 years | 
| The incidence of adverse events (Safety) | Safety and tolerability of sacituzumab govitecan will be evaluated using the National Cancer Institute-Common Terminology Criteria for Adverse Events version 5 (NCI-CTCAE v5). NCI-CTCAE is widely accepted in the community of oncology research as the leading rating scale for adverse events. This scale, divided into 5 grades (1 = mild, 2 = moderate, 3 = severe, 4 = life-threatening, and 5 = death) determined by the investigator, will make it possible to assess the severity of the disorders. | Throughout study completion, up to 36 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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breast cancer, metastatic, triple negative, sacituzumab govitecan, biomarker analysis