Residual Neuromuscular Blockade in Pediatric Anesthesia

Study Overview
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Brief Summary
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Residual neuromuscular blockade (RNB) is frequent and it is associated with postoperative morbidity and mortality. The incidence of the RNB in pediatric anesthesia is currently not known. The aim of this prospective observational cohort study is to evaluate the early RNB just before extubation and late RNB at the time of arrival to postanesthetic care unit (PACU).

Detailed Description
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Residual neuromuscular blockade (RNB) is frequent and it is associated with negative impact on postoperative morbidity and mortality. The incidence of the RNB in adult is well described, however in pediatric subpopulation it is currently not known. The aim of this prospective observational cohort study is to evaluate the early RNB just before extubation and late RNB at the time of arrival to postanesthetic care unit (PACU). In the trial will be enrolled all pediatric patients (28 weeks of age and older - 19 years old) whom will be administered neuromuscular blocking agent during anesthesia. The demographic data will be collected including: age, weight, type of surgery, ASA status. The anesthesia management will be described including: airway management, type and cumulative dose of neuromuscular blocking agent (NMBA) and time and dose of the last administered bolus of NMBA. The residual neuromuscular blockade will be measured according to the standards: TOF Watch accelerometry at the moment prior to extubation (two measurements) in TOF mode and at the arrival to postanesthetic care unit (PACU) (two measurements) in TOF mode.

Official Title
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Residual Neuromuscular Blockade in Paediatric Patients Before Extubation and in Postanesthetic Care Unit:Prospective Observational Cohort Study

Conditions
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Residual Neuromuscular Blockade

Intervention / Treatment
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* Device: Residual neuromuscular blockade measurement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Paediatric patients undergoing surgery with neuromuscular blocking agents were administered with the age limits Exclusion Criteria: weight under 3000 grams neuromuscular disease haemodynamic impairment (vasopressor need) planned postoperative mechanical ventilation

Ages Eligible for Study
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Minimum Age: 29 Weeks
Maximum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Paediatric patients after NMBA administration<br>Paediatric patients undergoing surgery with neuromuscular blockade | Device: Residual neuromuscular blockade measurement<br>* Just prior extubation in OR and at the arrival to PACU the residual neuromuscular blockade will be measured by accelerometry<br>* Other names: accelerometry;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Early residual neuromuscular blockade | Just prior extubation the residual neuromuscular blockade will be measured by accelerometry | before extubation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Late neuromuscular blockade | At the arrival to PACU the residual neuromuscular blockade will be measured by accelerometry | at arrival to PACU | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Residual neuromuscular blockade