Nutritional and Metabolic Management of Toxidermia Patients Requiring Intensive Care (TEN Metabolism)

Study Overview
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Brief Summary
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Retrospective observational cohort study including all patients admitted for toxidermia (Lyell syndrome, Stevens-Johnson Syndrome (SJS), or other extensive skin destruction) to the Burn unit of the adult ICU of the Lausanne burn center between 2006 and 2020. Inclusion criteria: age >18 years and admission to the burn-ICU for toxidermia whatever body surface affected. Exclusion criteria: to have declined access to the medical record, a stay shorter than 24 hours, and major burns. The observation period will be limited to the first 31 days of the ICU stay. All variables related to nutritional and metabolic management will be recorded

Detailed Description
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There are yet no description of the metabolic characteristics of patients admitted for Toxic epidermal necrolysis (TEN) or Stevens-Johnson Syndrome (SJS) which are a rare condition, often assimilated to major burns in terms of metabolic requirements. We will conduct a retrospective observational cohort study including all patients admitted for toxidermia (general term including TEN or Lyell syndrome, SJS, and other extensive skin destruction) to the Burn unit of the adult ICU of the Lausanne burn center between 2006 and 2020. The primary outcome will be compliance with the ICU's feeding protocol (feeding route, early start of enteral feeding, ), and secondary outcomes will include the adequacy of energy and protein delivery, and use of indirect calorimetry, and the comparison with both general and burn critically ill patients from prior studies in the ICU. Inclusion criteria: age >18 years and admission to the burn-ICU for toxidermia whatever body surface affected. Exclusion criteria: to have declined access to the medical record, and a stay shorter than 24hours, and major burns. The observation period will be limited to the first 31 days of the ICU stay. The recorded variables will include demographic characteristics, severity scores (SAPSII, SCORe of Toxic Epidermal Necrosis (SCORTEN for SJS/TEN), Nutrition risk screening (NRS) score), body surface area (BSA) affected by the disease, fluid intakes and balance (exudate volume estimation not included) of the first 10 days, body weight during the stay, renal function, length of mechanical ventilation and of ICU stay. Nutritional variables include the route of feeding, the 24hr energy prescription and delivery, protein, glucose, and lipid intakes, propofol, insulin, indirect calorimetry (IC) studies. Laboratory blood results include glucose, prealbumin, albumin, C-reactive protein (CRP), triglycerides, creatinine, and trace elements (Cu, Se, Zn). Descriptive statistics: Wilcoxon rank test, while Chi2 test, changes over time with one-way ANOVA .

Official Title
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Nutritional and Metabolic Characteristics of Critically Ill Patients Admitted for Severe Toxidermia

Conditions
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Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum

Intervention / Treatment
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* Dietary Supplement: Medical nutrition


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age >18 years admission to the burn-ICU Exclusion Criteria: declined access to the medical record stay shorter than 24hours

Ages Eligible for Study
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Minimum Age: 16 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Dietary Supplement: Medical nutrition|Nutrition therapy of the critically ill patients|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Compliance with ICU feeding protocol | Proportion of ICU days with covered needs | ICU stay, but maximum 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Protein delivery | Delivery of at least 1.1 g/kg day of protein | ICU stay but maximum 30 days | 
| Energy delivery | Delivery of at least 25 kcal/kg/day | ICU stay but maximum 30 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Metabolism, Nutrition, Protein, Critical care