Impact of a Multidisciplinary Consultation Program on Drug Adherence in First Oral Anticancer Treatment

Study Overview
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Brief Summary
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Oncology management has changed dramatically over the last decade with the approval and rapid adoption of newly targeted oral oncology medications. The movement to oral oncology medications has altered the balance of risks and adverse effects (AEs) in the treatment of cancer care. These treatments are associated with a different constellation of AEs and drug interactions. Patients receiving treatment with oral anticancer treatment (OAT) encounter several barriers to adherence, which may include limited access to specialty medications, severe adverse effects, complex medication regimens, and special handling precautions. Medication nonadherence not only reduces the efficacy of drug therapy but also has the potential to increase healthcare expenditures due to disease-related hospitalizations. The purpose of this study is to evaluate the drug adherence in cancer patients, using the medication possession ratio (MPR), before and after the implementation of a multidisciplinary consultation program (MCP), on initiation of OAT.

Official Title
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Impact of a Multidisciplinary Consultation Program on Drug Adherence in First Oral Anticancer Treatment

Conditions
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Multidisciplinary Consultation Program, Adherence to Oral Anticancer Treatment, Drug Related Toxicity, Securing Medication Management

Intervention / Treatment
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* Device: multidisciplinary consultation program


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: French speaking patients with a newly diagnosed or relapsed cancer, regardless of location and introduction of oral anticancer treatment Exclusion Criteria: patients treated with hormone therapy only Patient with severe psychiatric disorders patient who does not speak the French language

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| control group<br>patients in control group receive standard care | |
| intervention group<br>intervention group after implementation of a MCP | Device: multidisciplinary consultation program<br>* The multidisciplinary consultation program (MCP) was divided into 3 steps: the first step involved a consultation with an oncologist, the second step involved a consultation with an oncology pharmacist, and the third step involved a meeting with a coordinating nurse (CN). The CN put in place a regular telephone follow-up with the patient, a few days later (7 to 15 days), to ensure adherence and tolerance of the oral anticancer treatment (OAT).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| medication possession ratio (MPR) | The MPR makes it possible to determine the percentage of days of treatment covered by pharmacy dispensing. A patient is generally considered observant if MPR is greater than or equal to 80%. | two months | 
| medication possession ratio (MPR) | The MPR makes it possible to determine the percentage of days of treatment covered by pharmacy dispensing. A patient is generally considered observant if MPR is greater than or equal to 80%. | one year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Multidisciplinary consultation program, adherence to oral anticancer treatment, drug related toxicity, securing medication management