Geriatric Intervention Contribution on Quality of Life of Elderly Patients With Metastatic Neoplasia

Study Overview
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Brief Summary
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The aim of this study is to describe the impact of : Geriatric intervention contribution on quality of life of elderly patients receiving systemic treatments for metastatic neoplasia

Detailed Description
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Elderly cancer incidence increases exponentially with advancing age. However, elderly patients are largely underrepresented in cancer treatment trials. The geriatric population presents particular physical, mental, psychological or social specificities that may condition the prognosis especially for patients with metastatic neoplasia. Recently, the measurement of quality of life (QoL) in aging population is being recognized as an important part of clinical decision. It is therefore essential to set up prospective studies to evaluate the impact of oncogeriatric practices on the quality of life of elderly patients with metastatic neoplasia. The main objective of this prospective study is to describe the contribution of geriatric intervention on quality of life for for elderly (> 75 years) with metastatic solid cancer receiving systemic treatment during the first 6 months of their therapeutic management.

Official Title
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Description the Geriatric Intervention Contribution on Quality of Life of Elderly Patients With Metastatic Neoplasia : Prospective Descriptive Non-comparative Cohort ( QUALI Cohort)

Conditions
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Systemic Treatment, Metastatic Neoplasia, Elderly Patients

Intervention / Treatment
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* Other: geriatric intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient with solid metastatic neoplasia 75 years old or more Men or women ECOG between 0 and 3 Patient receiving systemic antineoplasic treatment (chemotherapy, hormonotherapy, immunotherapy, targeted therapy) Exclusion Criteria: ECOG 4 Localized cancer Patients already included in a study witch could modify quality of life Patient unable to give their consent

Ages Eligible for Study
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Minimum Age: 75 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group A : control group<br>Evaluation of quality of life with the EORTC QoL ELD 14 (Quality Qf Life ELDerly patients with 14 Questions) and QoL EORTC Q30 (Quality Qf Life with 30 Questions) for patients with G8 score > 14/17 | |
| Group B : geriatric intervention group<br>Evaluation of quality of life with the EORTC QoL ELD 14 (Quality Qf Life ELDerly patients) and QoL (Quality Qf Life) EORTC Q30 for patients with G8 score ≤14/17 ( in this arm there is two groups : patient who received geriatric intervention before treatment initiation (group A) and group of patient did not received geriatric intervention before treatment initiation( group B)) | Other: geriatric intervention<br>* Geriatric intervention<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Level of quality of life | Level of quality of life will be measured with the QoL ELD 14 (Quality Qf Life ELDerly patients with 14 Questions) | 6 months | 
| Level of quality of life | Level of quality of life will be measured with the QoL Q30 (Quality Qf Life with 30 Questions) | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of hospitalizations | number of hospitalizations will be reported | 6 months | 
| Duration of hospitalizations | Duration of hospitalizations will be reported in hours | 6 months | 
| Number of toxicities ( grade 3 and 4) | Number of toxicities (grade 3 and 4) will be reported according to the CTCAE v4.0 (Common Terminology Criteria for Adverse Events) | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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quality of life, elderly, metastatic neoplasia, systemic therapies