Periapical Bone Healing After Apicectomy With and Without Retrograde Root Filling

Study Overview
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Brief Summary
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Ph.D project: Periapical bone healing after apicectomy with and without retrograde root filling. The aim of this study is to assess periapical bone healing after apicectomy without a filling and apicectomy combined with a retrograde filling material, MTA. Further, we will estimate risk factors in non-healing cases. Study hypothesis: There is no difference in treatment outcome between: Periapical bone healing after apicectomy with retrograde root filling and Periapical bone healing after apicectomy without retrograde root filling

Detailed Description
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Ph.D project: Periapical bone healing after apicectomy with and without retrograde root filling. 60 patients have been selected from a group of 490 patients, who had a full mouth radiographic status taken in connection with a population study of apical periodontitis in Aarhus Community. The selection criteria for the 60 patients were patients with a persisting apical periodontitis, Periapical Index (PAI) score 3-5, on front teeth and premolars in the upper jaw. The orthograde root filling in the tooth must be at least 2 years old and sufficient regarding density and length. The 60 patients will be randomised into the two groups of apicectomy with and without filling. A radiograph will be taken just before the operation and 6 and 12 months after the operation. In the assessment of bone healing, we will use two different techniques, subtraction radiography and the Periapical Index (PAI). We will also evaluate the benefits of using the operation microscope during the operation, and if clinical photos can be useful as documentation of treatment result.

Official Title
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Periapical Bone Healing After Apicectomy With and Without Retrograde Root Filling

Conditions
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Stomatognathic Disease, Mouth Disease, Periapical Disease, Alveolar Bone Loss

Intervention / Treatment
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* Procedure: Mineral Trioxide Aggregate (MTA)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy person age 18 or above sufficient root filling sufficient coronal restauration apical infection for at least 2 years Pai Score3, 4, or 5 Exclusion Criteria: boneless more than 50 % communication between pocket and apical infection no visible root filling material after apicectomy facial bone less than 3 mm

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Mineral Trioxide Aggregate (MTA)|retrograde rootfilling with MTA or smoothening of the orthograde root-filling, gutta-percha|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Periapical bone healing Pai score |  | one-year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Periapical bone healing bone density |  | one-year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Apicoectomy, Retrograde, MTA