Invasive Candidiasis in Saudi ICUs

Study Overview
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Brief Summary
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Epidemiology and clinical outcomes of invasive candidiasis in critically ill patients in Saudi Arabia is not well studied. This observational study objectives include to determine the epidemiology, risk factors and outcomes of invasive Candida infection in critically ill patients in Saudi Arabia.

Official Title
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Invasive Candidiasis in Critically Ill Patients in Saudi Arabia: A Prospective Cohort Study

Conditions
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Invasive Candidiasis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adult patients (> 18 years) develop invasive candidiasis as per prespecified definitions during ICU stay In addition, patients who had invasive candidiasis within 72 hours of ICU admission will be included Exclusion Criteria: Diagnosis of invasive candidiasis (definite or probable) more than 72 hours before ICU admission. Diagnosis of invasive candidiasis (definite or probable) within 72 hours of ICU admission, but the admission to ICU for an unrelated reason. Readmission to the ICU during the same hospitalization with invasive candidiasis occurring during one of the previous admissions.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hospital Mortality | For patients staying in the ICU for long periods, hospital mortality will be censored at 180 days after entry into the study.That is patient staying alive in the hospital more than 180 days will be considered alive. | Patients will be followed while in the ICU and the vital status at the time of discharge from the ICU will be noted. The expected stay in the ICU is 10 days on average. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ICU Mortality | If patients are still alive in the ICU at 180 days after entring the sudy, they will be considered ICU survivors. | patients will be followed until discharge from the hospital and vital status at discharge from the hospital will be noted (expected hospital stay is 5 weeks). Hopsital mortality will be censored at 180 days after entry into the study. | 
| Duration of Mechanical Ventilation | If multiple intubations in the same admission, then the durations of mechanical ventilation will be added.This will be assessed for up to 180 days of stay in the ICU. | date of extubtation minus date of intubation | 
| Length of Stay in the ICU | Patients will be followed for up to 180 days.Patinets alive in the ICU beyond 180 days of stay will have an ICU length of stay of 180 days. | date of discharge from ICU minus date of admission to ICU | 
| Length of Stay in the Hospital | Patients will be followed for up to 180 days.Patinets alive in the hospital beyond 180 days of stay will have a hospital length of stay of 180 days. | date of discharge from hospital minus date of admission to hospital | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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candidiasis, critically ill, outcomes