Normative Values Laser Nociceptive Evoked Potentials Depending on the Age

Study Overview
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Brief Summary
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Different neurological damage may alter the pain conduction systems centrally (spinothalamic pathway) or peripherally (small caliber sensory fibers A delta and C). The laser thermal stimulation selectively stimulates the pain pathways and generates nociceptive signals conveyed to the cortex. Registering these cortical responses constitute the technical laser nociceptive evoked potentials. If these tests are routinely used, their interpretation must remain cautious especially in the elderly.

Detailed Description
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Different neurological damage may alter the pain conduction systems centrally (spinothalamic pathway) or peripherally (small caliber sensory fibers A delta and C). The laser thermal stimulation selectively stimulates the pain pathways and generates nociceptive signals conveyed to the cortex. Registering these cortical responses constitute the technical laser nociceptive evoked potentials. If these tests are routinely used, their interpretation must remain cautious especially in the elderly. Normal values that are available have been obtained in young subjects. However, various studies have shown that the integration of nociceptive messages depended on age. The aim of this study was to establish normal values of nociceptive evoked potentials for each age group of 18 to 75 years.

Official Title
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Normative Values Laser Nociceptive Evoked Potentials Depending on the Age

Conditions
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Healthy

Intervention / Treatment
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* Device: laser stimulations on lower limbs
* Device: laser stimulations cervical
* Device: 20 laser stimulations for each site on the upper limbs
* Device: laser stimulations on face and neck


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: major Exclusion Criteria: Neurological history Neuralgia history (> 3 months) Pathology can cause neuropathy (unbalanced thyroid dysfunction, diabetes, kidney failure, chronic hepatitis, HIV ...) Dermatological disorder known type of Lucite or photosensitivity Medical treatment analgesic, psychotropic or anti-epileptic underway Toxic acquired in the last 72 hours (alcohol, cannabis, other toxic ...) Pregnant women Incapacitate to stand still Participation in another biomedical research in the field of pain in the three months prior to inclusion.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: healthy volunteers<br>Healthy volunteers are able to participate to this study. They must not have neurological troubles. They will have different stimulations : laser stimulations on lower limbs laser stimulations cervical 20 laser stimulations for each site on the upper limbs laser stimulations on face and neck | Device: laser stimulations on lower limbs<br>* 20 laser stimulations for each site : back foot, outer face of the legs, and anterior thigh<br>Device: laser stimulations cervical<br>* 15 laser stimulations cervical areas below the ears.<br>Device: 20 laser stimulations for each site on the upper limbs<br>* 20 laser stimulations for each site : back of the hands and arms front face<br>Device: laser stimulations on face and neck<br>* 15 lasers stimulations for each site : mandibular areas and areas below the ears.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| composite outcomes : latencies (ms) and amplitudes (μV) of nociceptive evoked potential |  | Day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| detection threshold (mJ/mm2) |  | Day 0 | 
| nociceptive threshold (mJ/mm2) |  | day 0 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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healthy volunteers