Cambridge 7 Tesla Cerebral Small Vessel Disease Study

Study Overview
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Brief Summary
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CamSVD is jointly sponsored by the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust. We aim to explore and understand the underlying arterial pathology in Cerebral Small Vessel Disease (SVD) using ultra-high-field 7 Tesla MRI. We will optimise 7T Time-of-Flight MR angiography, blood suppressed MR sequence and phase-contrast (PC) MR angiography for visualization of perforating lenticulostriate arteries. This optimised sequences will be used to determine the range of arterial pathologies seen in individuals presenting with lacunar strokes. The pathologies of the perforating lenticulostriate arteries will be correlated with conventional clinical risk factors, cognition and radiological markers of SVD.

Official Title
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Imaging the Arterial Pathology in Cerebral Small Vessel Disease Using 7 Tesla Magnetic Resonance Imaging

Conditions
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Lacunar Stroke, Cerebral Small Vessel Ischemic Disease, Cerebral Small Vessel Diseases

Intervention / Treatment
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* Diagnostic Test: 7 Tesla Magnetic Resonance Imaging
* Other: Brief Memory and Executive Test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1. Symptomatic lacunar stroke with corresponding lacunar infarct on MRI Exclusion Criteria: Unable/unwilling to consent; Age<18; Stroke aetiology due to cardio-embolism or large vessel disease; Lacunar infarcts >1.5cm; Severe stroke (NIHSS score ≥16); Evidence of cortical infarct of any size; Other major neurological diseases; Severe systemic diseases such as heart failure, liver failure and kidney failure or any illness in the judgement of the investigator that could affect participation in the study; MRI contraindications e.g. metal objects in or on the body, claustrophobia, pregnancy, known allergy to gadolinium containing contrast agent, impaired renal function with estimated glomerular filtration rate (eGFR) <59ml/min/1.73m2.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with lacunar stroke due to SVD<br> | Diagnostic Test: 7 Tesla Magnetic Resonance Imaging<br>* Diagnostic Imaging<br>Other: Brief Memory and Executive Test<br>* Cognitive Assessment<br>|
| Healthy stroke free volunteers<br> | Diagnostic Test: 7 Tesla Magnetic Resonance Imaging<br>* Diagnostic Imaging<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Range and pattern of pathology seen in the perforating arteries like presence or absence of focal atheroma and narrowing |  | March 2020- | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differences in morphology of perforating arteries between SVD patients and healthy volunteers |  | March 2020- | 
| Correlation of morphology of perforating arteries with cardiovascular risk factors and radiological markers of SVD |  | March 2020- | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Vascular Cognitive Impairment, Vascular Dementia, 7 Tesla Magnetic Resonance Imagine (7T MRI)