linjc16/ctgov huggingface dataset:
Ivabradine Versus Propranolol for Induced Hypotension in Endoscopic Sinus Surgery

Study Overview
=================
Brief Summary
-----------------
the study is designed to compare the effect of addition of oral Ivabradine, propranolol to general anesthesia aimed reduction in blood loss during functional endoscopic sinus surgery.

Official Title
-----------------
Comparative Study Between Oral Ivabradine Versus Oral Propranolol for Induced Hypotension in Functional Endoscopic Sinus Surgery

Conditions
-----------------
Hypotension

Intervention / Treatment
-----------------
* Drug: oral Ivabradine
* Drug: oral Propranolol


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age of 18 - 60 years. Patients of both genders. ASA grade I - II . Exclusion Criteria: Patient refusal. Any contraindication to medication included in the study . Patients with allergy to medication included in the study.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Ivabradine group<br> | Drug: oral Ivabradine<br>* Ivabradine group will receive ivabradine 5mg PO in the evening and 1 hour before anesthetic induction<br>|
| Experimental: propranolol group<br> | Drug: oral Propranolol<br>* propranolol group will receive propranolol 10 mg PO in the evening and 1 hour before anesthetic induction.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in blood loss | Estimated blood loss in millilitres per hour is calculated by subtracting the volume of total irrigation used during the case from the total amount of fluid in the suction canister at the end of surgery in addition, pre-weighing and post-weighing of sponges and oropharyngeal packs were also done and dividing by surgical time in hours. assessment of blood loss by Boezaart and van der Merwe Grading System for bleeding during Endoscopic Sinus Surgery | immediately after the surgery |
Evaluation of Tolsura When Used as Prophylaxis After Lung Transplantation

Study Overview
=================
Brief Summary
-----------------
This is a single-center, observational study of Tolsura PK sampling in lung transplant recipients

Detailed Description
-----------------
Patients who are receiving Tolsura as part of their clinical care will be asked to enroll and EMR data and excess biological samples will be collected

Official Title
-----------------
Evaluation of Tolsura When Used as Prophylaxis After Lung Transplantation

Conditions
-----------------
Lung Transplant Infection

Intervention / Treatment
-----------------
* Drug: Tolsura


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years of age and older hospitalized at UPMC placed on Tolsura prophylactically by clinical team patients who have had or will have a lung transplant. Exclusion Criteria: redo lung transplant recipient with dual liver-lung transplant patients with previous history of SOT including other organ transplantation patients with known pre-transplant colonization with moulds resistant to azoles patients with intra-transplant positive cultures for moulds in either transplant recipient or his/her donor patients with a history of hypersensitivity reaction to an azole agent patients who are kept NPO (nothing by mouth, including meds) recipients or donor with HepC PCR positive

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| lung transplants<br>Lung transplants on Tolsura for infection | Drug: Tolsura<br>* Patients fulfilling the inclusion criteria (see above) and placed on Tolsura for prophylaxis, and signed informed consent to participate in this study will be part of the study.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PK Sampling-measure amount of drug in system | blood samples around a dosing of Tolsura to determine maximum plasma concentration | one day PK sampling | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rates of infection post treatment with Tolsura | follow lung transplant recipients till end of Tolsura treatment and determine rates of infection for as well as type of infections | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
lung transplant
Internet-Versus Group-Administered Cognitive Behavior Therapy for Panic Disorder

Study Overview
=================
Brief Summary
-----------------
Panic Disorder with or without agoraphobia (PD/A) is a common, and unless it is treated, often chronic psychiatric disorder. The are effective pharmacological as well as psychological treatments for PD/A. Because of the lack of availability of the most effective psychological treatment, cognitive behavior therapy (CBT), self-help based CBT treatments have been developed. One of those are Internet-based CBT. The aim of this study is to compare the effectiveness of Internet and group CBT for PD/A in a regular psychiatric setting. 113 patients are consecutively and randomly assigned to either treatment (both lasting 10 weeks). The main outcome measure is the Panic Disorder Severity Scale(PDSS). The study hypothesis is that treatments will show equal effectiveness.

Official Title
-----------------
Internet- Versus Group-Administered Cognitive Behavior Therapy for Panic Disorder in a Psychiatric Setting: A Randomized Equivalence Trial

Conditions
-----------------
Panic Disorder

Intervention / Treatment
-----------------
* Behavioral: Internet-based cognitive behavior therapy (CBT).
* Behavioral: Group CBT


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Primary Panic Disorder with or without Agoraphobia (PD/A) Exclusion Criteria: active substance abuse physiological etiology of panic symptoms under 18 years of age severe depression or suicidal ideation. if on drugs for PD, not having had a constant dosage for 2 months undergoing other cognitive behavioral treatment

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Internet CBT<br>Internet-based cognitive behavior therapy (CBT). | Behavioral: Internet-based cognitive behavior therapy (CBT).<br>* Self-help program and guidance by psychologist via e-mail during 10 weeks.<br>|
| Experimental: Group CBT<br>Group cognitive behavior therapy (CBT). | Behavioral: Group CBT<br>* Group cognitive behavior therapy (CBT) during 10 weeks.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Panic Disorder Severity Scale (PDSS) |  | Pre, post at 6-month follow-up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Montgomery-Åsberg Depression Rating Scale (MADRS) Anxiety Sensitivity Index (ASI) Sheehan Disability Scale (SDS) |  | Pre, post and 6-month follow-up |
A Survey to Evaluate Diabetes Management, Control, Chronic Complications, Psychosocial Aspects of Diabetic Subjects in Thailand

Study Overview
=================
Brief Summary
-----------------
This study is conducted in Asia. The aim of this observational study is to evaluate current status of diabetes management, control, complications in diabetic subjects in Thailand.

Official Title
-----------------
DiabCare Asia 2008. A Cross-Sectional Survey to Evaluate Diabetes Management, Control, Complications, Psychosocial Aspects of Diabetic Patients in Asia and To Evaluate Perceptions and Practices of Physicians and Patients About Diabetes Management in Asia

Conditions
-----------------
Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2

Intervention / Treatment
-----------------
* Other: No treatment given


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diabetic patients registered in the particular centre for more than 12 months. Patients should have visited the centre at least once in the last 3-6 months apart from the initial visit. Patients willing to sign informed consent form. Exclusion Criteria: Repetition of any patient as patients should not be included twice for any reason. Unwilling to participate or unable to comply with protocol requirements.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| A<br> | Other: No treatment given<br>* Capillary or venous blood will be drawn for analysing HbA1c.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean blood glucose parameters of diabetic patients |  | Study start | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patients' perception will be analysed through patient questionnaire measuring psychological well-being, quality of life and patients' compliant to treatment |  | Study start | 
| Physician perception of diabetes and its management will be analysed through physician questionnaire measuring awareness about HbA1c test and its goal, anti-diabetic treatment and barriers towards optimum diabetes control |  | Study start | 
| Duration of diabetes associated with highest number of diabetic complications |  | Study start | 
| Minimum duration of diabetes associated with 10% incidence of diabetic complications (CVD, Nephropathy and retinopathy) |  | Study start |
A Single-center Trial of Patients With Aortic Dissection in the Chinese XinJiang Province

Study Overview
=================
Brief Summary
-----------------
To evaluate epidemiological features of risk factors for aortic dissection (AD) in Chinese XinJiang Province patients.

Detailed Description
-----------------
The epidemiological features of risk factors for aortic dissection (AD) in China were obtained from developed population in east of China, however, such information was not available for the remote population. Moreover, people in the western region have significant difference with developed population in lifestyle, diet, ethnic and so on. Therefore, the aim of our study was to evaluate epidemiological features of risk factors for AD in Chinese remote patients. We anticipated that this analysis would provide helpful information preventing and controlling AD in Chinese XinJiang Province.

Conditions
-----------------
Aortic Dissection

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical diagnosis of aortic dissection ≥18 years old good compliance with the instructions and cooperate with follow-up voluntarily signed the informed consent form Exclusion Criteria: pregnant or lactating female bad compliance with the instructions and follow-up estimated remaining life is less than 12 months Aortic aneurysm、Acute Myocardial infarction、Acute Cerebral accident

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Case<br>Diagnosis of aortic dissection was based on history and physical examination, and confirmed by imaging, visualization at surgery, and/or postmortem examination. Simple aortic aneurysm and pseudoaneurysm were excluded. Simple aortic aneurysm and pseudoaneurysm were excluded. Surgical and endovascular treatments were the main interventions and performed in the case group. | |
| Control<br>As the control group, patients without AD were obtained from the hospitalized patients in the same period. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Participants with related events for aortic dissection in Chinese XinJiang population |  | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Aortic Dissection, Chinese XinJiang Province
Minimally Invasive Vestibular Neurectomy Versus Tenotomy of the Stapedius and Tensor Tympani Muscles in the Management of Patients With Unilateral Meniere's Disease

Study Overview
=================
Brief Summary
-----------------
The distinctive symptoms of Meniere's disease (MD) include recurrent vertigo spells, fluctuating hearing loss, aural fullness and tinnitus. Conservative treatment in MD comprises lifestyle modifications, such as low-sodium diet, avoidance of caffeine, alcohol and stress, in addition to medication such as diuretics and betahistine. When conservative treatment fails, surgical management is attempted. Surgical interventions comprise transtympanic steroids or gentamicin, endolymphatic sac surgery (ES), ventilation tube placement, vestibular neurectomy, and labyrinthectomy. Recently, Loader et al. have presented encouraging results of the effectiveness of tenotomy of the stapedius and tensor tympani muscles (TSTM) in the management of patients with definite MD. Also, satisfactory results were obtained with endoscopic assisted minimally invasive vestibular neurectomy (MIVN). The aim of this study is to compare the clinical outcomes of MD patients who were submitted to either MIVN or TSTM in our department.

Official Title
-----------------
Minimally Invasive Vestibular Neurectomy Versus Tenotomy of the Stapedius and Tensor Tympani Muscles in the Management of Patients With Unilateral Meniere's Disease

Conditions
-----------------
Ménière

Intervention / Treatment
-----------------
* Procedure: Surgical treatment
* Procedure: Surgical treatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: unilateral definite Meniere's disease. Exclusion Criteria: other peripheral or central vestibular disorders, bilateral MD and neurologic disorders. Previous history of chronic otitis media or middle ear surgery.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Minimally invasive vestibular neurectomy<br> | Procedure: Surgical treatment<br>* Endoscopic retrosigmoid minimally invasive vestibular neurectomy<br>|
| Active Comparator: Tenotomy of the stapedius and tensor tympani muscles<br> | Procedure: Surgical treatment<br>* Endoscopic tenotomy of middle ear muscles<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| dizziness handicap inventory (DHI) | contains 25 questions divided into physical, emotional, and functional subgroups. Each question is to be answered using a scale with ''no'' (0 points), ''sometimes'' (2 points), or ''yes'' (4 points). The total score ranges from zero (no incapacity) to 100 (severe incapacity). | 6 months after surgery |
Prevalence of Cardiovascular Risk Factors in Upper Vestibular Neuritis

Study Overview
=================
Brief Summary
-----------------
Vestibular neuritis is the second cause of vertigo, it constitutes 5 to 6% of the aetiologies of vertigo in an otoneurological consultation. Infection or reactivation of a neurotropic virus of the herpes group (HSV-1) in the vestibular lymph node is thought to be the cause of the unilateral vestibular deficit. Upper vestibular neuritis is more common than lower, or total involvement. Goebel (2) explains this by an anatomical predisposition of the vestibular nerve canal to inflammation, unlike the singular nerve canal which is shorter and wider giving way to a certain degree of edema without consequence on its contents. However, the innervation territory of the superior vestibular nerve is superimposable on the territory supplied by the anterior vestibular artery. The anterior, lateral semicircular canals and the utricle are affected. Current complementary vestibular and imaging examinations cannot differentiate between inflammatory or vascular involvement in upper vestibular neuritis. The increased presence of cardiovascular risk factors in patients with upper vestibular neuritis would be an argument in favor of ischemic involvement of the anterior vestibular artery.

Official Title
-----------------
Prevalence of Cardiovascular Risk Factors in People With Upper Vestibular Neuritis

Conditions
-----------------
Vestibular Neuritis

Participation Criteria
=================
Eligibility Criteria
-----------------
nclusion criteria: Major subject (≥18 years old), Subject having presented an episode of upper vestibular neuritis recorded on the Video Head Impulse Test Ulmer device at the HUS between 01/01/2016 and 01/31/2020, Subject not having expressed his opposition, after information, to the reuse of his data for the purposes of this research. Exclusion criteria: Patient who expressed his opposition to participating in the study, Total vestibular neuritis, impossibility of providing the subject with enlightened information (difficulties in understanding the subject, etc.) Subject under safeguard of justice, Subject under guardianship or guardianship, Lack of video head impulse test data.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Retrospective study of cardiovascular risk factors in people with upper vestibular neuritis |  | Files analysed retrospectively from January 01, 2016 to January 31, 2020 will be examined] | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Vestibular neuritis, Anterior vestibular artery
Effect of Ile-Pro-Pro (IPP) on Endothelial Function in Patients With Coronary Artery Disease

Study Overview
=================
Brief Summary
-----------------
This study will investigate whether the lacto-tripeptide Ile-Pro-Pro (IPP) improves the function of the endothelium in patients with coronary artery disease. The study has a crossover design. Participants will be treated with a protein hydrolysate rich in IPP for 12 weeks and placebo for 12 weeks with a four-week rest period between treatment periods. The investigators will use ultrasound to test the function of the endothelium in the brachial artery before, after 6 weeks, and after 12 weeks of each treatment. Blood will be collected before and after each treatment. The investigators hypothesize that IPP will improve endothelial function.

Official Title
-----------------
Effect of a Protein Hydrolysate Rich in Lacto-tripeptide (IPP) on Hyperemic Blood Flow and Flow-mediated Dilation in Patients With Coronary Artery Disease

Conditions
-----------------
Coronary Artery Disease

Intervention / Treatment
-----------------
* Dietary Supplement: IPP
* Other: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Coronary artery disease Exclusion Criteria: Treatment with an ACE inhibitor or ARB Pregnancy Other major illness Treatment with an investigational drug within 4 weeks

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Intervention/Treatment |
| --- |
|Dietary Supplement: IPP|Protein hydrolysate rich in lacto-tripeptide (IPP) up to 5 to 15 mg/day|
|Other: Placebo|Matching placebo capsules|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Brachial Artery Flow-Mediated Dilation and Reactive Hyperemia |  | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Carotid-Femoral Pulse Wave Velocity |  | 12 weeks | 
| Leg Reactive Hyperemia |  | 12 weeks | 
| Digital Pulse Amplitude Tonometry |  | 12 weeks | 
| Blood pressure |  | 12 weeks |