Effect of Isometric Handgrip Training on Cardiovascular Risk in Hypertensives

Study Overview
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Brief Summary
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The main purpose this study is to analyze the effects of isometric handgrip training on cardiovascular risk in hypertensive. For this, approximately 60 hypertensive, under anti-hypertensive medication, will be selected and randomly distributed into three groups: home-based isometric handgrip training (HBT), supervised isometric handgrip training (ST) and control group (CG).Subjects assigned to the HBT and ST will train three times per week for a total of 12 weeks, will perform a bout of isometric handgrip exercise: four sets of 2-min isometric contractions (using alternate hands) at 30% of maximal voluntary contraction. However, the subjects of the HBT group conduct the training without daily supervision. Subjects randomized to the CG will be encouraged to increase the level of physical activity and make healthy eating, without, however, receive specific recommendations.Baseline and after 12 weeks of intervention, the following cardiovascular risk indicators will be obtained: blood pressure, arterial stiffness, cardiac autonomic modulation, vasodilatory capacity and oxidative and inflammatory stress markers, in addition to microalbuminuria. For data analysis, in addition to descriptive statistics, two-way ANOVA for mixed model will be applied for within and between groups comparison. If the premises of this test are met. The level of significance that will be adopted is p<0.05.

Official Title
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Effect of Isometric Handgrip Training on Cardiovascular Risk in Hypertensives

Conditions
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Hypertension

Intervention / Treatment
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* Other: Isometric handgrip training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical diagnosis of hypertension; Must be under anti-hypertensive medications of three months or more; May not present diabetes or other cardiovascular diseases; May not engaged in regular physical activity; May not have disabilities that compromise the physical activity practices. Exclusion Criteria: Not perform more than 85% of the training sessions; Present diagnosis of metabolic diseases, cardiovascular or pulmonary during the study; Adherence to other physical activity program beyond the training offered by this study; Change in class and / or dose of medication during the study; Not using the medication regularly; Worsening of the disease.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Home-based isometric handgrip training<br>All participants that will be assigned to home-based isometric handgrip training (HBT) will train three times per week for a total of 12 weeks, will perform a bout of isometric handgrip exercise: four sets of 2-min isometric contractions (using alternate hands) at 30% of maximal voluntary contraction; however, the training will be performed without daily supervision. Therefore, the subjects will receive a logbook to record the exercise sessions. In addition, visits will be scheduled at weeks 1, 3, 6, 9 and 11 to provide feedback to individuals and discuss potential problems in conducting training. | Other: Isometric handgrip training<br>* The two experimental groups (HBT and ST) will receive intervention with isometric handgrip exercise for 12 weeks, and the HBT group without daily supervision.<br>* Other names: Exercise;|
| Experimental: Supervised isometric handgrip training<br>All participants that will be assigned to supervised isometric handgrip training (ST) will train three times per week for a total of 12 weeks, will perform a bout of isometric handgrip exercise: four sets of 2-min isometric contractions (using alternate hands) at 30% of maximal voluntary contraction with. The training will be performed with daily supervision. | Other: Isometric handgrip training<br>* The two experimental groups (HBT and ST) will receive intervention with isometric handgrip exercise for 12 weeks, and the HBT group without daily supervision.<br>* Other names: Exercise;|
| No Intervention: Control group<br>Subjects randomized to the control group (CG) will be encouraged to increase the level of physical activity and make healthy eating, without, however, receive specific recommendations | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in office blood pressure |  | Baseline and 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in ambulatory blood pressure |  | Basaline and 12 weeks | 
| Change in central blood pressure |  | Basaline and 12 weeks | 
| Change in cardiac autonomic modulation |  | Baseline and 12 weeks | 
| Change in vasodilatory capacity |  | Baseline and 12 weeks | 
| Change in arterial stiffness |  | Baseline and 12 weeks | 
| Change in markers of oxidative stress |  | Baseline and 12 weeks | 
| Change in markers of inflammation |  | Baseline and 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Isometric Handgrip