The Optical Coherence Tomography in Age-Related Macular Degeneration Study: The OCT in AMD Study

Study Overview
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Brief Summary
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The Optical Coherence Tomography (OCT) is a non-contact, non invasive method to examine the retina by providing cross-sectional scans through the retina. Measurements of the retinal thickness based on automatically set border lines created by threshold algorithm provide information concerning the amount of intraretinal fluid and activity of the lesion. In this study the reproducibility of retinal thickness measurements in patients suffering from age-related macular degeneration performed by two independent examiners of two examinations of the same day but performed in a time interval of at least two hours should be evaluated. Using the macular thickness program of stratus OCT, 6 radial lines through the center of the foveal avascular zone are performed, Differences between the first and second measurement will be investigated by a 95% confidence interval, a Bland-Altman plot (with corresponding regression analysis) and a random effect model with time, examiner and diagnosis as fixed factors. Although threshold algorithm failures and fixation problems are common in age-related macular degeneration evidence of reproducibility and repeatability of maximum retinal thickness is expected.

Official Title
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Reproducibility of Retinal Thickness Measurements by Optical Coherence Tomography in Age-Related Macular Degeneration The OCT in AMD Study

Conditions
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Macular Degeneration

Intervention / Treatment
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* Other: examination only


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age over 50 years Age related macular degeneration Exclusion Criteria: Macular pathologies other than age related macular degeneration (diabetic maculopathy, macular pucker, macular hole, Visualization of the macula not possible (dens cataract, vitreous haemorrhage) Not consented patients

Ages Eligible for Study
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Minimum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| A<br>examination twice by examiner 1 | Other: examination only<br>* OCT performed twice<br>|
| B<br>examination first by examiner 1 thereafter by examiner 2 | Other: examination only<br>* OCT performed twice<br>|
| C<br>examination first by examiner 2 thereafter by examiner 1 | Other: examination only<br>* OCT performed twice<br>|
| D<br>examination performed twice by examiner 2 | Other: examination only<br>* OCT performed twice<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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age-related macular degeneration, optical coherence tomography, retinal thickness, exudative age-related macular degeneration