linjc16/ctgov huggingface dataset:
Genomic DNA in Human Blastocoele Fluid

Study Overview
=================
Brief Summary
-----------------
The objective will focus on the characterization of DNA fragments present in Blastocoele fluid, and the evaluation of these fragments as potential target for Preimplantation Genetic Diagnosis. To reach this goal, real-time PCR, Whole Genome Amplification techniques and -subsequently- Next Generation Sequencing and aCGH approaches will be used.

Conditions
-----------------
Chromosomal Aneuploidies, Single Gene Desease

Intervention / Treatment
-----------------
* Other: blastocoele aspiration


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: IVF patient with supernumerary embryos to vitrify at blastocyst stage Exclusion Criteria: IVF patient without blastocyst formation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Bastovit<br>all the patients that have supernumerary embryos to vitrify at blastocyst stage | Other: blastocoele aspiration<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of samples with DNA in blastocoele Fluid | the presence of DNA will be evaluated through rtPCR | 6 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of euploid samples | Array CGH | 8 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Blastocoele fluid, Human DNA, molecular diagnosis
Pseudohyponatremia of Multiple Myeloma is True Hyponatremia

Study Overview
=================
Brief Summary
-----------------
Hypothesis: the hyponatremia of multiple myeloma (m.m.)is true and not pseudohyponatremia by using the stewart approach to acid - base interpretation, would like to show that the positive charged m- proteins produced in m.m.result in true hyponatremia.

Official Title
-----------------
a Study to Evaluate the Electrolyte Changes in Particular Sodium,in Multiple Myeloma and the Effect of the m- Proteins on the Strong Ion Difference

Conditions
-----------------
Hyponatremia of Multiple Myeloma

Intervention / Treatment
-----------------
* Other: blood test


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with multiple myeloma

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| blood test<br>to measure levels of sodium, albumin and acid - base status in venous blood | Other: blood test<br>* blood test to measure levels of: sodium, albumin and acid - base status in venous blood.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hyponatremia present or not |  | one year | 
| hyponatremia | pseoudohyponatremia or not | one year |
Impact of Football Matches on the Emergency Admissions of a Level III Maternity During EURO 2016

Study Overview
=================
Brief Summary
-----------------
Attendances at an emergency department (ED) are often considered to depend on different factors such as moonlight, welfare checks, weather, and major sporting events. Data regarding effects of large sporting events on the workload of ED often assessed decreased patient volume, especially male use. Currently, no data are available on the effect of major televised sporting events on obstetrical visits. The aim of this study is to examine whether televised soccer games from a major sporting tournament, (Euro 2016) influence the level of attendance at an obstetrical ED and could have implications for women's welfare. In the summer of 2016, France hosted the largest European sporting event of the year 2016: the European Football Championships (Euro 2016). A total of 51 games were played over a month, bringing together the biggest European teams. An observational, retrospective study is conducted during this period on the number of emergency visits in a French tertiary Maternity hospital (Maternity of Nancy).

Official Title
-----------------
Impact of Football Matches on the Emergency Admissions of a Level III Maternity During EURO 2016

Conditions
-----------------
Gynecologic Disease

Intervention / Treatment
-----------------
* Other: Emergency visit in a French tertiary Maternity hospital (Maternity of Nancy)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All female patients admitted urgently to the Regional Maternity Hospital between June 10 and July 10, 2016 Exclusion Criteria: refusal of the patient information and understanding impossible
Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Emergency visit in a French tertiary Maternity hospital (Maternity of Nancy)|total number of visits (hospitalizations and consultations)|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall number of maternity emergencies admissions during EURO 2016 (10June-10July) |  | At the end of EURO 2016 on 10th July 2016 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of daily admissions and per 2 hours time slot every day from June 10th to July 10th |  | At the end of EURO 2016 on 10th July 2016 |
The Comparison of Uniportal and Tubeless Video Assisted Thoracic Surgery and Transbronchial Lung Cryobiopsy in the Diagnosis of Interstitial Lung Disease

Study Overview
=================
Brief Summary
-----------------
To compariing the uniportal and tubeless video assisted thoracic surgery and trnsbronchial lung cryobiopsy within the multidisciplinary discussion context in the diagnosis of interstitial lung disease，and assess the safety and cost-effectiveness. This is a prospective control trial.

Official Title
-----------------
The Comparison of Uniportal and Tubeless Video Assisted Thoracic Surgery and Transbronchial Lung Cryobiopsy Within the Multidisciplinary Discussion Context in the Diagnosis of Interstitial Lung Disease

Conditions
-----------------
Surgical Lung Biopsy, Transbronchial Lung Cryobiopsy, Interstitial Lung Disease

Intervention / Treatment
-----------------
* Diagnostic Test: lung biopsy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 yrs ≤ age<75yrs Patients diagnosed as interstitial lung disease with comprehensive clinical data (including history, serological test, spirometry test and high resolution computed tomography) Further pathological data was still required after multidisciplinary discussion. Exclusion Criteria: Severe pulmonary dysfunction: forced vital capacity (FVC) ≤65% or carbon-monoxide diffusion coefficient (DLco) ≤45% of predicted value Pulmonary hypertension: An estimated systolic pulmonary artery pressure>50mmHg on echocardiography Abnormal coagulation parameters or thrombocytopenia (<50*109/L) Severe comorbidities leading to inoperable condition Patients cannot give consent or refuse biopsy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: uniportal and tubeless video assisted thoracic surgery<br>lung biospy by the uniportal and tubeless video assisted thoracic surgery | Diagnostic Test: lung biopsy<br>* transbronchial lung cryobiopsy<br>|
| Experimental: transbronchial lung cryobiopsy<br>transbronchial lung cryobiopsy | Diagnostic Test: lung biopsy<br>* transbronchial lung cryobiopsy<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnotic yield | Percentage of definitive diagnosis within the multidisciplinary discussion context by two different biopsy methods | two weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
surgical lung biopsy, transbronchial lung cryobiopsy, interstitial lung disease
Management of Severe Congenital Blepharoptosis

Study Overview
=================
Brief Summary
-----------------
Frontalis sling surgery was carried out using Ptose-up under general anaesthesia for patients with severe congenital ptosis.

Detailed Description
-----------------
Frontalis sling surgery was carried out using Ptose-up for patients with severe congenital ptosis in 23 eyes of 15 patients and they followed up for at least 6 months to detect the success rate and if there is any postoperative complications.

Official Title
-----------------
Evaluation of Polytetrafluoroethylene (Ptose-up) in Management of Severe Congenital Blepharoptosis

Conditions
-----------------
Blepharoptosis

Intervention / Treatment
-----------------
* Procedure: Ptosis surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Severe congenital blepharoptosis Poor levator muscle function No previous ptosis surgery Exclusion Criteria: Patients with Jaw winking phenomenon Blepharophimosis syndrome Congenital myasthenia

Ages Eligible for Study
-----------------
Minimum Age: 11 Months
Maximum Age: 9 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: severe congenital ptosis<br>Patients with severe congenital ptosis with poor levator muscle function | Procedure: Ptosis surgery<br>* Frontalis sling surgery using pose-up and Wright's fascia-lata needle<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improvement of ptosis | The average marginal reflex distance was improved from -0.8 mm preoperative to +2.73 mm after 3 months | 3 months |
Effects of Social Skills and Physical Activity Training on Recreational Activities in Youth

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to examine the effect of social skills training on adolescents physical activity levels. For one week at the beginning and end of the study teens will wear a BioTrainer to measure their activity levels and also wear a pager to communicate the types of activities they are doing throughout the day. For 8 weeks participants will be randomized into one of two groups, a social skills training group or a physical activity group. The investigators predict that both groups will experience an increase in physical activity and social involvement (decrease time spent alone).

Official Title
-----------------
Effects of Social Skills and Physical Activity Training on Recreational Activities in Youth

Conditions
-----------------
Social Skills, Physical Activity

Intervention / Treatment
-----------------
* Behavioral: Social Skills Training
* Behavioral: Physical Activity Training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Boys and girls ages 12-14 Youth who encounter problematic relationships with their peers Exclusion Criteria: Youth should have no psychopathology, developmental disabilities, or asthma that would limit participation Youth should have no cold or upper respiratory distress or a condition that could influence their activities Youth should not be taking medications that could affect their level of activity

Ages Eligible for Study
-----------------
Minimum Age: 12 Years
Maximum Age: 14 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Social Skills Training<br> | Behavioral: Social Skills Training<br>* Social skills group will consist of one session (60 minutes) per week for 8 weeks<br>|
| Experimental: Physical Activity Training<br> | Behavioral: Physical Activity Training<br>* Physical activity groups consist of one session (60 minutes) per week for 8 weeks<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| physical activity levels |  | pre and post intervention | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
social skills, physical activity, peer relationships, childhood obesity, changes in physical activity, changes in social involvement
Study to Determine Racial and Gender Differences in Platelet Aggregation

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to see if there is a racial and/or gender difference in platelet aggregation.

Detailed Description
-----------------
Genetic variability of various components of the coagulation system has been reported. Data on racial and gender differences in platelet aggregation are lacking. We hypothesize that there are significant racial and gender differences on aggregatory response of platelets to commonly used agonists to evaluate platelet function such as adenosine diphosphate (ADP), epinephrine, collagen and arachidonic acid.

Official Title
-----------------
Phase 1 Study to Determine Racial and Gender Differences in Platelet Aggregation

Conditions
-----------------
Platelet Aggregation

Intervention / Treatment
-----------------
* Procedure: Blood Draw


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Race of Caucasian, African American, or Hispanic Exclusion Criteria: Chronic medical conditions Tobacco use Regular non-steroidal anti-inflammatory use, aspirin use, or use of one of the other anti-platelet drugs.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Blood Draw|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Healthy volunteers
Compare ELP in Patients With Elective Phaco-VTX Surgery in One Eye and a Single Lens Phaco Surgery on the Other Eye

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to gain more insight into the potential impact of a vitrectomy (removal of the vitreous) on postoperative effective position of the intraocular lens (IOL). Moreover, this study can provide very useful information for the optimal lens calculation in patients undergoing lens extraction with IOL implantation (whether or not combined with a vitrectomy) should undergo.

Detailed Description
-----------------
Comparison ELP post phaco VTX (pucker / floaters) versus post phaco and use this information to develop a customized IOL calculation for eyes undergoing phacoVTX. Evidence for recording lens thickness (LT) parameter in the IOL strength calculation in KWS (in the calculation of the ELP in the light of the Olsen formula, using the C-constant) in order to be able to make an even more accurate prediction of the post-operative diopter target of the patient.

Official Title
-----------------
Vergelijking Van de Postoperatieve Effectieve Lenspositie (ELP) Bij patiënten Gepland Voor Een Electieve Phacovitrectomie-ingreep (Phaco-VTX) Aan één Oog en Enkel Een Lensingreep Phaco Aan Het Andere Oog

Conditions
-----------------
Macular Pucker

Intervention / Treatment
-----------------
* Procedure: phaco-vitrectomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age > 50 yrs macular pucker wherefore vitrectomy is necessary Exclusion Criteria: macular pathology other than macular pucker Corneal pathology Other ocular pathology that could affect the biometrics or ELP Previous vitrectomy in one of the eyes

Ages Eligible for Study
-----------------
Minimum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: macular pucker wherefore vitrectomy<br>one eye phaco-vitrectomy and other eye only phaco. No other involvement of drug or device. Standard of care procedure | Procedure: phaco-vitrectomy<br>* phaco-vitrectomy. No other involvement drug or device. Standard of care procedure<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Compare if ELP is different or the same at phaco or phaco-vitrectomy | Anterior chamber depth measured using IOL master. | 6 - 8 weeks |
Ultrasonographic Evaluation of Diabetic Neuropathy

Study Overview
=================
Brief Summary
-----------------
The current study aimed to evaluate the cross-sectional area (CSA) of peripheral nerves in people with diabetic peripheral neuropathy using ultrasonography and correlate the CSA with clinical and demographic data.

Detailed Description
-----------------
Patients with diabetic peripheral neuropathy (n=53) and a matched healthy control group (n=53) underwent blinded ultrasonography imaging of the sciatic, tibial and median nerves. Matching was performed according to patient body mass index (BMI), sex and age. CSAs of the nerves were recorded, and the associations between pain intensity (measured with a visual analog scale [VAS]), the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) pain scale, diabetes mellitus duration, BMI, HbA1c and blood glucose levels were evaluated.

Official Title
-----------------
Diabetic Peripheral Neuropathy: Correlation Between Ultrasound Findings and Clinical Features

Conditions
-----------------
Diabetic Peripheral Neuropathy

Intervention / Treatment
-----------------
* Other: Ultrasonographic evaluation of nerves in diabetic patients
* Other: Ultrasonographic evaluation of nerves of healthy volunteers


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: type 2 diabetes mellitus Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) scores ≥ 12 probable diabetic peripheral neuropathy according to the diabetic peripheral neuropathy criteria. Exclusion Criteria type 1 diabetes mellitus hypothyroidism LANSS pain scale scores < 12 body mass index (BMI) > 35 current pregnancy histories of hereditary neuropathy, inflammatory neuropathy, nerve trauma, or other known causes of polyneuropathy; and the use of anti-neuropathic drugs.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with diabetes mellitus<br>Group I; the patients with diabetes mellitus who had peripheral neuropathy as diagnosed. | Other: Ultrasonographic evaluation of nerves in diabetic patients<br>* Ultrasonographic evaluation of peripheral nerves in patients with diabetes mellitus which have peripheral neuropathy<br>* Other names: ultasonographic evaluation;|
| Control<br>Group II; healthy volunteers | Other: Ultrasonographic evaluation of nerves of healthy volunteers<br>* evaluation of peripheral nerves and correlated with group I<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain scores on the visual analog scale |  | 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neuropathic pain scores on the Leeds Assessment of Neuropathic Symptoms and Signs pain scale |  | 3 years |