The Bern Perioperative Biobank

Study Overview
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Brief Summary
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The goal of the research is to define clinically relevant molecular markers for increased risk of peri-/ postoperative organo-dysfunctions, inflammation, adverse events and disease progression. To better understand the perioperative impact the investigators aim to determine perioperative levels of molecular markers over time in the available samples and clinical data of the Bern perioperative Biobank (BPBB) cohort to finally increase quality of perioperative care of patients by permitting preventive measures to be taken early in patients at risk.

Official Title
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The Bern Perioperative Biobank to Define Perioperative Changes of Molecular Markers of Perioperative Organo-dysfunctions, Inflammation, Adverse Events and Disease Progression

Conditions
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Anesthesia, Surgical Procedure, Operative

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 years and older Written informed consent Non-emergency surgery Exclusion Criteria Transient incapacity to consent or insufficient time (< 6h) to consider study participation No informed consent Cognitive impairment/Patients unable to consent Patients who retrospectively expressed their wish to be excluded

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| All patients<br>Consenting patients undergoing non-emergency surgery with anesthesia | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assessing the change of the metabolic profile in the perioperative setting | Surgery causes significant disruption of physiologic metabolism. The investigators currently lack specific markers to assess change of the metabolic profile in the perioperative setting. The investigators aim to identify metabolic markers and their change in the perioperative period in association with patients' clinical outcome. | Before induction of anesthesia as baseline | 
| Assessing the change of the metabolic profile in the perioperative setting | Surgery causes significant disruption of physiologic metabolism. The investigators currently lack specific markers to assess change of the metabolic profile in the perioperative setting. The investigators aim to identify metabolic markers and their change in the perioperative period in association with patients' clinical outcome. | Ca. 2-5hours later upon finishing the surgery | 
| Assessing the change of the metabolic profile in the perioperative setting | Surgery causes significant disruption of physiologic metabolism. The investigators currently lack specific markers to assess change of the metabolic profile in the perioperative setting. The investigators aim to identify metabolic markers and their change in the perioperative period in association with patients' clinical outcome. | On postoperative day 1 during the morning round between 07:30-9:00am | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Genetic association study