Evaluate the Effect of Hyaluronic Acid in the Treatment of Furcation Involvement

Study Overview
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Brief Summary
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the effect Hyaluronic Acid in the Treatment of Furcation Involvement

Detailed Description
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The materials to be used in the study are the following: Hyaluronic acid Cone-beam computed tomography(CBCT) x-ray The patients with Grade II furcation will be divided into two groups. Both groups will have the same number of patients and the same procedure, such as the scaling root planning. However, the control group will use hyaluronic acid and membrane. The placebo group, on the other hand, will use hyaluronic acid without membrane and will use CBCT x-ray. The x-rays will be done at the beginning of the treatment. Then, two monitoring processes will be done. The first monitor will be done after three months. The data will be recorded. Then, after another three months, the patients will undergo an x-ray check again, and the data will be recorded. The goal is only to have the patients exposed to x-ray twice so they would not be compromised to the high dose of radiation. The evaluation to be done for the 3-month interval will only be clinical assessments.

Official Title
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Evaluate the Effectiveness of Bioactive Hyaluronic Acid in the Treatment of Furcation Involvement

Conditions
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Furcation Defects

Intervention / Treatment
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* Procedure: hyaluronic acid


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Selected teeth: Permanent first and second molars in the mandible. Furcation dimension: Radiographic and clinical evidence of exhibiting defects due to Grade II furcation with at least 2 millimeters probing depth horizontally and at least 5 millimeters probing depth circumferential. Gender: both males and females. Age range: between 18 and 55 years. Health status: healthy patients non-systemic diseased except controlled diabetic. Compliance: Patients will be willing and able to comply with adequate oral hygiene protocols. Exclusion Criteria: Patients that received periodontal regenerative therapy within the past 12 months. Patients that are lactating. Pregnant patients. Smokers. Patients with pulp infection. Patients with trauma resulting from occlusion. Patients with receding gum. Patients with tooth mobility greater than grade II. Patients that will not comply with the hygiene protocols in Phase I therapy. Patients with potential illnesses that can influence the periodontal therapy outcomes. Patients that are taking medications that can interfere with the healing outcomes of the periodontal wound. Patients allergic to any drugs.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: test group use membrane and hyaluronic acid ,control group use membrane without hyaluronic acid
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group A (control)<br>preoperative cone-beam computed tomography (CBCT) scans N=9 open flap debridement. use membrane without hyaluronic acid. (The first monitor will be done after three months. The data will be recorded. After another three months, the patients will undergo an x-ray check again, and the data will be registered. The goal is to have the patients exposed to x-ray twice not to be compromised to a high radiation dose. The evaluation to be done for the 3-month interval will only be clinical assessments|) | Procedure: hyaluronic acid<br>* after flap refection, the furcation area will be debrided then add hyaluronic acid 8% and cover it with a collagen membrane<br>|
| Active Comparator: Group B (test)<br>preoperative cone-beam computed tomography (CBCT )scans N= 9 open flap debridement. use membrane and 8% hyaluronic acid gel (The first monitor will be done after three months. The data will be recorded. After another three months, the patients will undergo an x-ray check again, and the data will be registered. The goal is to have the patients exposed to x-ray twice not to be compromised to a high radiation dose. The evaluation to be done for the 3-month interval will only be clinical assessments|). | Procedure: hyaluronic acid<br>* after flap refection, the furcation area will be debrided then add hyaluronic acid 8% and cover it with a collagen membrane<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| evaluate the regenerative effect of hyaluronic acid | measurement of the bone gain after the treatment with hyaluronic acid in millimeters | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Hyaluronic Acid, Furcation involvement