Main Branch Versus Side Branch Ostial Lesion

Study Overview
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Brief Summary
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The investigators studied the relations between coronary angiography (CAG), intravascular ultrasound (IVUS) and fractional flow reserve (FFR) in coronary ostial lesions.

Detailed Description
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Angiographic evaluation for ostial lesions is reported to be inaccurate in the assessment of the functional and clinical significance of a lesion. The investigators studied the relations between coronary angiography (CAG), intravascular ultrasound (IVUS) and fractional flow reserve (FFR) in coronary ostial lesions.

Official Title
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Relationship Between Fractional Flow Reserve and Coronary Angiography/Intravascular Ultrasound Parameters in Ostial Lesions: Major Coronary Ostial Lesions Versus Side Branch Ostial Lesions

Conditions
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Coronary Artery Stenosis

Intervention / Treatment
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* Device: Fractional flow reserve
* Device: IVUS


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 21-85 Presence of at least one obstructive coronary artery stenosis at coronary ostium as defined by: Previous catheterization with any coronary ostium lesion 50% or greater Ability and Willingness to provide informed consent Ability and Willingness to perform required follow up procedures Exclusion Criteria: History of coronary artery bypass graft surgery left main coronary ostial lesion significant stenosis at proximal or distal part of coronary ostium lesion ostial lesion related to infarcton Creatinine>1.6 mg/dL or GFR<30 pre-procedure per institutional standards Ejection fraction lower than 40% Known Pregnancy Arrhythmia Contrast agent allergy that cannot be adequately premedicated Patient not a candidate for IVUS and FFR Inability or unwillingness to provide informed consent Inability or unwillingness to perform required follow up procedures

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| ostial lesion<br>ostial lesion will be evaluated by IVUS and FFR | Device: Fractional flow reserve<br>* Fractional flow reserve measured by pressure wire<br>* Other names: Radi Pressure Wire(Radi Medical Systems, Uppsala, Sweden);Device: IVUS<br>* intravascular ultrasound :IVUS was performed in a standard fashion using an automated motorized pullback system (0.5mm/s) with commercially available imaging catheter<br>* Other names: iLab® Ultrasound Imaging System(Boston Scientific/SCIMED, Minneapolis, MN, USA);|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| lumen area | lumen area at ostial lesion | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| angiographic stenosis, % plaque area | angiographic and intravascular ultrasound parameters at ostial lesions of each major branch and side branch. | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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FFR, IVUS, QCA