ESP Block in Radical Prostatectomy

Study Overview
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Brief Summary
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Our study aimed to examine the effects of ultrasound guided erector spinae plane block in radical prostatectomy surgery on pain and surgical stress response, to reduce adrenocortical and sympathetic discharge due to anesthesia and surgery, and to reduce peroperative opioid analgesic consumption.

Detailed Description
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In this study 46 patients between the ages of 30-74, American Society of Anesthesiologists (ASA) score I-II and undergoing radical prostatectomy surgery at T.R. Ministry Of Health İstanbul Göztepe Prof. Dr. Süleyman Yalçın City Hospital were included. The patients were randomly divided into two groups as ESPB applied Group B (n=23) and not Group K (n=23). Patient-controlled analgesia (PCA) was initiated in all patients for postoperative analgesia. Patients' demographic data (age, gender, ASA score), intraoperative hemodynamic data, intraoperative and postoperative additional narcotic consumption, postoperative Numeric Rating Scale (NRS) scores (postoperative 0, 5 and 20 minutes and Then, 1, 3, 6, 12, 18 and 24 h), postoperative nausea-vomiting scores and possible complications related to block and / or surgery were recorded.Intraoperative MAP, HR, SpO2, BIS values of patients in both groups were recorded every 5 minutes. Blood glucose, insulin, cortisol, prolactin and C-reactive protein (CRP) were studied three times; preop morning at 6:00, intraoperative when surgical incision closing and postoperative 24h. in order to evaluate the surgical stress response in the patients.

Official Title
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Effects of Ultrasound Guided Erector Spinae Plane Block in Radical Prostatectomy Surgery on Pain and Surgical Stress Response

Conditions
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Erector Spinae Plane Block

Intervention / Treatment
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* Procedure: ESP block


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA I-II Exclusion Criteria: diabetes coagulopathy local anesthetic drug allergy long hospitalization history, hormone disorder advanced organ failure history of steroid use vertebral anomalies mental retardation

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 74 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: ESP group<br> | Procedure: ESP block<br>* Before general anesthesia, ESP block was applied from the T12 vertebra level with 10 ml 0.5% bupivacaine HCL 5 ml 2% lidocaine HCL 5 ml 0.9% isotonic NaCl mixture<br>|
| No Intervention: control group<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Numeric Pain Scale | Between 1-10. 1: no pain, 10: worst possible pain | postoperative 24 hours. | 
| Blood glucose | mg /dL | postoperative 24 hours. | 
| insulin | µIU/mL | postoperative 24 hours. | 
| cortisol | µg/dL | postoperative 24 hours. | 
| prolactin | µg/L | postoperative 24 hours. | 
| C-reactive protein | mg/L | postoperative 24 hours. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Remifentanil Consumption Speed | µg /kg/dk | 3 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Erektor Spinae Plane Block, Postoperative Analgesia, Surgical Stress Response