Association Between Hypermobility and Chronic Musculoskeletal Pain

Study Overview
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Brief Summary
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Study hypothesis:- Benign joint hyper mobility syndrome which persists into adulthood is a special type of benign joint hyper mobility which is more likely to predispose to chronic musculoskeletal pain. Young Indian adults aged between 25 and 40 years who are blood donors or relatives of patients admitted as inpatient or presenting to the out patient department, in Amrita Institute of Medical Sciences will be enrolled, after excluding the exclusionary criteria. They will be assessed for the presence of chronic musculoskeletal pain using a validated self filled questionnaire. The primary investigator who will be blinded to their response will examine them for the presence of Benign Joint Hyper mobility Syndrome and for tender points suggestive of fibromyalgia. Primary Objective:- To determine whether chronic musculoskeletal pain is associated with Hypermobility among Indian adults. Study design:- Cross sectional survey

Official Title
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A Study of Association Between Hypermobility And Chronic MusculoSkeletal Pain:a Pilot Study

Conditions
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Hypermobility, Joint, Arthralgia, Myofascial Pain Syndromes, Fibromyalgia, Pain Disorder

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Completed their 25th birthday Not yet celebrated their 40th birthday Are relatives of patients being treated in Amrita Institute of Medical Sciences or voluntary blood donors in the same institute Exclusion Criteria: Subjects who have been diagnosed previously with a inflammatory musculoskeletal disease. Subjects detected to have signs or symptoms of inflammatory arthritis on a detailed clinical examination and history taking. Subjects who have symptoms suggestive of diabetes mellitus or hypothyroidism or have been previously diagnosed with the same. Subjects who are not willing to participate. Subjects who have been diagnosed as having a connective tissue disorder or have a family history of the same.

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Young healthy Indian adults<br>Persons aged between 25 and 40 years of age who are relatives of patients being treated in Amrita Institute of Medical Sciences (Inpatient or Outpatient) and voluntary blood donors at the same institute who are willing to participate in the study. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To determine whether chronic musculoskeletal pain is associated with hypermobility among young Indian adults |  | 3-6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determine whether hypermobility is associated with the presence of fibromyalgia in young Indian adults. |  | 3-6 months | 
| Determine the prevalence of hypermobility among Indian adults |  | 3-6 months | 
| Determine prevalence of fibromyalgia in young Indian adults |  | 3-6 months | 
| Determine the prevalence of chronic musculoskeletal pain among young indian adults |  | 3-6 months | 
| Determine the association between American College of Rheumatology criteria for definition of Fibromyalgia and Simplified intensity scale questionnaire definition of Fibromyalgia. |  | 3-6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Chronic musculoskeletal pain, Benign joint hypermobility syndrome, Fibromyalgia