Nutritional Study of Fish Oil in Skin Quality in Healthy Women

Study Overview
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Brief Summary
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The skin acts as a barrier against the external environment and prevents water loss from the body. Aging is a natural process leading to changes in the skin and fish oil has been shown to prevent inflammation, hyperpigmentation and UV-damage. This pilot study will determine skin characteristics after intervention with north atlantic fish oil.

Detailed Description
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Women will be recruited to a placebo or fish oil group and be examined at pre- and post for skin quality parameters such as wrinkles, fine lines and trans-epithelial water loss.

Official Title
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A Randomised, Two-armed, Double-blinded Nutritional Study of Fish Oil on Skin Quality in Healthy Women

Conditions
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Skin Health

Intervention / Treatment
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* Dietary Supplement: Placebo
* Dietary Supplement: Ceto 10


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy women in the age of 30-65 Able to follow the following dietary restriction for 4 months (4 weeks wash-out, 3 months intervention): Do not take omega-3 supplements do not take supplements containing vitamin A do not take supplements containing collagen try to avoid using skin products containing vitamin A do not undergo skin treatment Exclusion Criteria: Pregnancy or breast feeding known allergy to seafood skin treatment the last 6 months planned skin treatment during the study period -

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Placebo controlled, double blind intervention study.
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo<br>4x1g corn oil capsules | Dietary Supplement: Placebo<br>* 1g corn oil capsules<br>|
| Experimental: Ceto 10<br>4x1g capsules containing containing broad spectrum marine oil from north atlantic fish | Dietary Supplement: Ceto 10<br>* 1g capsules containing oil broad spectrum marine oil from north atlantic fish<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determine the change in skin quality of healthy women after supplementation with fish oil compared to corn oil | Changes in quantitative analysis of facial inflammation, wrinkles and fine lines and skin texture will be performed using the VISIA Skin Analysis system. Measurements will be made at baseline and at end of supplementation period. | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determine the change in omega-3 index (%EPA and DHA in red blood cells) after daily intake of 4g of north atlantic fish oil compared to placebo | Fatty acid profiles will be measured from blood samples using the Omega-quant test | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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fish oil, skin, inflammation, wrinkles, trans epithelial water loss, LCMUFA