French Pediatric Helicobacter Pylori Observatory

Study Overview
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Brief Summary
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Helicobacter pylori is a major human pathogen associated with significant morbidity. The treatment oriented by the antibiogram or PCR (Polymerase Chain Reaction) should be privileged in children. However, the optimal treatment for the eradication of pediatric H. pylori infection is still not established. No French consensus conference on the management of H. pylori infection in children taking into account the epidemiological data available for this infection has been published. The description of diagnostic and therapeutic management procedures has not yet been specifically described according to the country of birth of children. The main objective is to collect data enabling the establishment of a French observatory of Helicobacter pylori in children in order to provide a national database.

Official Title
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Data Collection for the Creation of the French Pediatric Helicobacter Pylori Observatory

Conditions
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Helicobacter Pylori Infection

Intervention / Treatment
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* Other: Collection of data


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Child with confirmed H. pylori infection by direct diagnostic methods after periendoscopic gastric biopsies Age < 18 No opposition of at least one of the 2 parents to the use of health data for research purposes Exclusion Criteria: Child with confirmed H. pylori infection by indirect diagnostic methods

Ages Eligible for Study
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Minimum Age: 0 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| children with H. pylori infection<br> | Other: Collection of data<br>* The following data will be collected by the physician : sociodemographic profile (age, sex, country of birth of child and parents); clinical manifestations; endoscopic aspects (esophagus, duodenum, stomach); different methods of diagnosis of infection; different primary and secondary bacterial resistance profiles ; different first and second line therapeutic combinations; different first and second line bacterial eradication rates ; different signs of side effects and tolerance of first and second line treatments; different methods of bacterial eradication control.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnosis of H. pylori infection | Child with confirmed H. pylori infection by direct diagnostic methods (Histology, Bacterial culture, PCR) on perendoscopic gastric biopsies | at inclusion | 
| Age |  | at inclusion | 
| Sex |  | at inclusion | 
| Country of birth |  | at inclusion | 
| Clinical symptoms |  | at inclusion, 3 and 6 months | 
| Microbiological diagnosis |  | at inclusion, 3 and 6 months | 
| Endoscopic diagnosis |  | at inclusion, 3 and 6 months | 
| Rates of bacterial resistance profiles |  | at inclusion, at 3 and 6 months | 
| antibiotic therapy |  | at inclusion, 3 and 6 months | 
| Bacterial eradication rates |  | 3 and 6 months | 
| Side effects and tolerance of first and second line treatments |  | 3 and 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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children, treatment, observatory