Effectiveness if Premedication With Single Dose Piroxicam and Prednisolone After a Single Visit Root Canal Treatment .

Study Overview
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Brief Summary
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Two drugs (Piroxicam and Prednisolone)are being compared for post operative endodontic pain after a single visit root canal treatment for 74 hours.

Detailed Description
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To evaluate effectiveness of single dose premedication with piroxicam(20mg) and prednisolone(20mg) on post endodontic pain after a single visit root canal treatment . patient will be recalled every day for 4 days to know the pain scale using visual analogue scale .

Official Title
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Effectiveness of Single Dose Pre Medication of Piroxicam and Prednisolone on Post Endodontic Pain After a One Visit Root Canal Treatment. Randomized Trial .

Conditions
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Post-operative Endodontic Pain

Intervention / Treatment
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* Drug: Piroxicam 20 mg
* Drug: prednisolone 20 mg


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient ages from 20-40 years(28). Single rooted tooth with symptomatic irreversible pulpitis. With no analgesic or anti-inflammatory drug taken within a week period before procedure. Exclusion Criteria: Patients presenting with any systemic disease Patients already taking premedication for endodontic pain. Pregnant or lactating patients. Multirooted teeth. Teeth with Pulpal necrosis. Previously treated or initiated root canal treatment. Patient presenting with allergy due to drug

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: subjects are randomly placed into one of the three groups: Placebo, Piroxicam (20 mg), Prednisolone (20 mg). The drugs will be given thirty minutes before procedure starts,followed by one visit root canal procedure. Postoperative pain will be evaluated up to 96 hours interval using a visual analog scale.
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: control<br>group 1 , is no intervention group in which root canal procedure will be done without drug as ideal protocol . | |
| Experimental: Piroxicam<br>group 2 is given Piroxicam 20 mg half an hour before root canal treatment to manage post operative pain. | Drug: Piroxicam 20 mg<br>* Piroxicm is from oxicam family of anti inflammatory drug that inhibits prostaglandin synthesis and effectively lower pain threshold levels<br>|
| Experimental: Prednisolone<br>group 3 is given Prednisolone 20mg half an hour before root canal treatment to manage post operative pain. | Drug: prednisolone 20 mg<br>* prednisolone is from steroid family of anti inflammatory drug that inhibit arachidonic acid and effectively lowers the pain<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| post operative pain | post operative pain will be measured after single visit endodontic treatment using visual analog scale with readings 1 to 10 from 24 hours till 76 hours | 76 hours |