Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders

Study Overview
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Brief Summary
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RATIONALE: Learning about the side effects of stereotactic radiosurgery in patients with brain tumors or other brain disorders may help doctors plan treatment and help patients live more comfortably. PURPOSE: This clinical trial is studying the acute side effects in patients who are undergoing stereotactic radiosurgery for brain tumors or other brain disorders.

Detailed Description
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OBJECTIVES: Determine the incidence and types of acute complications in patients undergoing stereotactic radiosurgery for brain tumors or other brain disorders. Determine the time frame for development and resolution of these complications in these patients. Determine the severity of these complications in these patients. OUTLINE: Patients undergo stereotactic radiosurgery. Patients also complete questionnaires about the side effects they experience from radiosurgery. The questionnaires are completed at baseline and at 1 week, 1 month, and 2 months after radiosurgery. PROJECTED ACCRUAL: A total of 94 patients will be accrued for this study.

Official Title
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Prospective Study on the Short-Term Adverse Effects From Gamma Knife Radiosurgery

Conditions
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Brain and Central Nervous System Tumors, Metastatic Cancer, Radiation Toxicity

Intervention / Treatment
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* Other: Questionnaire


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Diagnosis of brain tumor or other brain disorder, including, but not limited to, 1 of the following: Primary brain tumors Brain metastases Acoustic neuromas Pituitary adenomas Parkinson's disease Cluster headaches Glomus jugulare Epilepsy Obsessive compulsive disorder Arteriovenous malformations Trigeminal neuralgia Eligible for and scheduled to undergo stereotactic radiosurgery PATIENT CHARACTERISTICS: Performance status Not specified Life expectancy Not specified Hematopoietic Not specified Hepatic Not specified Renal Not specified Other No physical or mental limitation that would preclude study compliance PRIOR CONCURRENT THERAPY: Endocrine therapy Concurrent steroids allowed Radiotherapy No prior stereotactic radiosurgery

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Questionnaire|Patients complete questionnaires about the side effects they experience from radiosurgery. The questionnaires are completed at baseline and at 1 week, 1 month, and 2 months after radiosurgery.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Short-term adverse effects as assessed by a questionnaire | Patients undergo stereotactic radiosurgery. Patients also complete questionnaires about the side effects they experience from radiosurgery. The questionnaires are completed at baseline and at 1 week, 1 month, and 2 months after radiosurgery. | at 1 week, 1 month, and 2 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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radiation toxicity, tumors metastatic to brain, adult anaplastic astrocytoma, adult anaplastic ependymoma, adult anaplastic meningioma, adult anaplastic oligodendroglioma, adult brain stem glioma, adult central nervous system germ cell tumor, adult choroid plexus tumor, adult craniopharyngioma, adult diffuse astrocytoma, adult ependymoblastoma, adult ependymoma, adult giant cell glioblastoma, adult gliosarcoma, adult medulloblastoma, adult melanocytic lesion, adult meningeal hemangiopericytoma, adult meningioma, adult myxopapillary ependymoma, adult oligodendroglioma, adult papillary meningioma, adult pineoblastoma, adult pineocytoma, adult subependymoma, adult supratentorial primitive neuroectodermal tumor (PNET), adult grade I meningioma, adult grade II meningioma, adult grade III meningioma, adult mixed glioma, recurrent adult brain tumor, adult pilocytic astrocytoma, adult glioblastoma, ACTH-producing pituitary tumor, growth hormone-producing pituitary tumor, nonfunctioning pituitary tumor, prolactin-producing pituitary tumor, recurrent pituitary tumor, TSH producing pituitary tumor