Effect of Diode Laser on Sensitive NCCLs Prior to Composite Restoration

Study Overview
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Brief Summary
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This study will investigate the efficacy of three diode laser wavelengths 445 nm, 660 nm, 970 nm when applied just before placement of composite restoration on reducing postoperative sensitivity from Non-carious cervical lesions (NCCLs) with class V cavity preparation.

Detailed Description
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In this randomized clinical trial, patients with NCCLs will be included (four teeth in each participant). After class V cavity preparation in the NCCLs, the teeth will be randomly assigned into four groups according to diode laser irradiation wavelength Group 1 (placebo) laser simulation and Group 2 (445 nm) diode laser wavelength, Group 3 (660 nm) diode laser wavelength, and Group 4 (970 nm) diode laser wavelength. Following laser irradiation, the universal self-etch adhesive will be applied and all the cavities will be restored with the same resin composite. Tooth sensitivity to a cold stimulus will be recorded using a visual analogue scale (VAS) before treatment and on follow-up days 1, 14 followed by 1, 3, and 6 month after treatment.

Official Title
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Effect of Low-Level Diode Laser on Dentin Topography And Sensitive Non-Carious Cervical Lesions Prior to Composite Restoration (A Split-mouth Randomized Controlled Trial)

Conditions
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Dentin Hypersensitivity

Intervention / Treatment
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* Other: Placebo
* Radiation: 445 nm Diode Laser Wavelength
* Radiation: 660 nm Diode Laser Wavelength
* Radiation: 970 nm Diode Laser Wavelength


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: NCCLs on the Buccal Surface of Teeth, Maxilla, or Mandible. Preoperative VAS Score > 2. Good Oral Hygiene. Score (0-1.2). Teeth Must be Vital. Exclusion Criteria: Teeth with a History of Trauma, Dental caries, Defective Restoration, Pulpitis, Occlusal Restoration. Teeth with Periodontal Disease or History of Surgical Procedure. Use of Desensitizing Toothpaste or Solutions in the Past 3 Month. Patients Taking Analgesics within 72 h Before Sensitivity Testing. Patients with Known Allergic Reactions Against Any Material to be Used. Patients with a History of Psychological Diseases and those Taking Antipsychotic Medications. Pregnancy or Nursing. Unwillingness of the Patient to the Treatment Procedure.

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 64 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: In this randomized controlled clinical trial, patients with NCCLs will be included (four teeth in each participant). The teeth will be randomly assigned into four groups according to diode laser irradiation wavelength Group 1 (placebo) laser simulation, Group 2 (445 nm) diode laser wavelength, Group 3 (660 nm) diode laser wavelength, and Group 4 (970 nm) diode laser wavelength.
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo<br>Laser Simulation | Other: Placebo<br>* Laser Simulation<br>|
| Experimental: 445 nm<br>445 nm Diode Laser Wavelength (SiroLaser Blue) | Radiation: 445 nm Diode Laser Wavelength<br>* The Axial Surface of Class V Cavity will be Irradiated Using a 445 nm Diode Laser Wavelength<br>|
| Experimental: 660 nm<br>660 nm Diode Laser Wavelength (SiroLaser Blue) | Radiation: 660 nm Diode Laser Wavelength<br>* The Axial Surface of Class V Cavity will be Irradiated Using a 660 nm Diode Laser Wavelength<br>|
| Experimental: 970 nm<br>970 nm Diode Laser Wavelength (SiroLaser Blue) | Radiation: 970 nm Diode Laser Wavelength<br>* The Axial Surface of Class V Cavity will be Irradiated Using a 970 nm Diode Laser Wavelength<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To Clinically Assess Change in Dentin Hypersensitivity Between Baseline and After Exposure to Diode Laser Radiation. | Dentin Hypersensitivity is Determined using Cold Stimulus. Utilizing Visual Analog Scale (VAS) Reading 0-10 Where 0 is No Pain, While 10 is the Most Experienced Pain. | Change in Pain Scores From Baseline on the Visual Analog Scale at Day 1, Day 14, Followed by 1,3, and 6 Month Postoperatively. |