Impact of Sleep Apnea on Sepsis Mortality

Study Overview
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Brief Summary
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By clinical record review, this retrospective study aims to compare the mortality of sepsis patients with versus without obstructive sleep apnea, who were diagnosed and treated in Taipei Veterans General Hospital, Taiwan.

Detailed Description
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This retrospective study aims to compare the mortality of sepsis patients with versus without obstructive sleep apnea (OSA). Patients with a diagnosis of sepsis, who had received a prior polysomnography at Taipei Veterans General Hospital during Jan. 1, 2001 to May 31, 2017 will be enrolled. Obstructive sleep apnea (OSA) is defined by an apnea-hypopnea index at least 5/hr with compatible symptoms. Their clinical record will be reviewed and data including demography, polysomnography and details related to sepsis (source of infection, number of organ dysfunction at initial diagnosis of sepsis and survival time) will be collected. The start of the survival time (follow-up time) is the date when sepsis is diagnosed. The end of the survival time (follow-up time) is the date of death or end of hospitalization (date of discharge). Survival analyses will be performed.

Official Title
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The Impact of Sleep Apnea on the Mortality of Sepsis - A Retrospective Study

Conditions
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Sepsis, Mortality, Sleep Apnea Syndromes

Intervention / Treatment
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* Biological: OSA


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who received received a polysomnography at Taipei Veterans General Hospital during Jan. 1, 2001 to May 31, 2017 Patients who were admitted with a diagnosis of sepsis after the polysomnography The diagnosis of sepsis fulfilling the clinical criteria Exclusion Criteria: Younger than 20 years Not compatible with a definition of sepsis subjects with incomplete data

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sepsis patients with OSA<br>Sepsis patients who received a prior polysomnography showing an apnea-hypopnea index at least 5/hr with compatible symptoms | Biological: OSA<br>* The diagnosis of OSA (obstructive sleep apnea) relies on polysomnographic data showing an apnea-hypopnea index at least 5/hr with compatible symptoms.<br>|
| Sepsis patients without OSA<br>Sepsis patients who received a prior polysomnography showing an apnea-hypopnea index less than 5/hr | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | percentage of sepsis patients died of sepsis | up to 40 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Survival time | Survival time is defined as the length from the date when sepsis is diagnosed to date of discharge or death | up to 40 days | 
| Mortality | percentage of sepsis patients died of sepsis | 7-day | 
| Mortality | percentage of sepsis patients died of sepsis | 28-day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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sepsis, obstructive sleep apnea, outcome, prognosis, sleep-disordered breathing