linjc16/ctgov huggingface dataset:
Incidence and Risk Factors of Early Onset Colorectal Cancer

Study Overview
=================
Brief Summary
-----------------
Early onset colorectal cancer (cancer in person younger than 50 years) has increasing incidence last years. The aim of our study was to assess the real-life incidence of early onset colorectal cancer, advanced neoplasias (colorectal cancer and/or advanced adenoma) and all neoplastic lesions in total in a single non-university endoscopic center.

Detailed Description
-----------------
The investigators retrospectively assessed the incidence of all neoplastic lesions, advanced neoplasias and colorectal cancer in population under 50 years of age compared to population 50 years and older. The investigators collected the data from all colonoscopic examinations performed in non-university hospital Frydek-Mistek from January 2012 to the end of June 2021.

Official Title
-----------------
Incidence and Risk Factors of Early Onset Colorectal Cancer

Conditions
-----------------
Colorectal Neoplasms

Intervention / Treatment
-----------------
* Other: colonoscopy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: all patient who underwent colonoscopic examination clear indication for colonoscopy Exclusion Criteria: not able to underwent colonoscopy

Ages Eligible for Study
-----------------
Minimum Age: 4 Years
Maximum Age: 97 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 50 years and over<br>patients who underwent colonoscopic examination aged 50 years and over | Other: colonoscopy<br> <br> |
| under 50 years<br>patients who underwent colonoscopic examination aged under 50 years | Other: colonoscopy<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| incidence of early onset colorectal neoplasias, risk factors | the real-life incidence of early onset colorectal cancer, advanced neoplasias (colorectal cancer and/or advanced adenoma) and all neoplastic lesions in total in a single non-university endoscopic center, the risk of sex and family history of colorectal cancer | 10 years |
An Analysis of Presentation and Outcome Following Treatment of Pancreatic Endocrine Neoplasms

Study Overview
=================
Brief Summary
-----------------
A single institutional study of Pancreatic Endocrine Neoplasms over 18 years.

Detailed Description
-----------------
The investigators did an analysis from a prospectively maintained database of patients who underwent pancreatic resections or nonresective procedures for neoplasms of the pancreas at Sir Ganga Ram Hospital from 1995 to 2013 and using pathological reports and preoperative CT scan as the gold standard, the investigators identified 40 patients with PENs.

Official Title
-----------------
A Single Centre Analysis of Clinical Characteristics and Treatment of Endocrine Pancreatic Tumours.

Conditions
-----------------
Pancreatic Endocrine Neoplasms

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pathological reports and Prooperative CAT Scan showing Endocrine Pancreatic Tumours Exclusion Criteria: Nonendocrine Pancreatic Tumours
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pancreatic Endocrine Neoplasms<br>We did an observational analysis from a prospectively maintained database of patients who underwent pancreatic surgery for neoplasms of the pancreas at Sir Ganga Ram Hospital, New Delhi, India from 1995 to 2013 and using pathological reports and preoperative CT scan as gold standard, we identified 40 patients with PENs. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nonfunctioning and Malignant Pancreatic Endocrine Neoplasms | Of the 40 patients operated for Pancreatic Endocrine Neoplasms, using clinical criteria, histopathological analysis and preoperative imaging as gold standard, nonfunctioning and functioning tumours were identified. Similarly the number of benign and malignant lesions identified were recorded as per the WHO Classification of pancreatic endocrine tumours. | Each participant was followed up for a period of 5 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Endocrine Pancreas, Pancreatic Endocrine Neoplasm
Pharmacogenetic Study in Patients Received Iron Chelating Agent

Study Overview
=================
Brief Summary
-----------------
To investigate effect of genetic variations on the toxicities and find optimal target population, the investigators planned to analyze the genetic polymorphisms of UDP-glucuronosyltransferase.

Detailed Description
-----------------
Transfusion-associated iron overload induces systemic toxicity. Recently, deferasirox, a convenient long acting oral agent, has been introduced in clinical practice with promising efficacy. However, some patients experience drug-related toxicities and cannot tolerate it. To investigate effect of genetic variations on the toxicities and find optimal target population, we planned to analyze the genetic polymorphisms of UDP-glucuronosyltransferase 1A (UGT1A) subfamily, multi-drug resistance-associated protein 2 (MRP2) and breast cancer resistance protein (BCRP) among pediatric patients received deferasirox.

Official Title
-----------------
Pharmacogenetic Study in Patients Received Iron Chelating Agent

Conditions
-----------------
Hemosiderosis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients who received deferasirox because of transfusion associated iron overload (Transfusion associated iron overload was defined as ferritin ≥ 1,000 ng/mL in patients who needed over 8 units of RBC transfusions per a year). Patients with written informed consents Exclusion Criteria: Patients or parents refusal

Ages Eligible for Study
-----------------
Maximum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Genetic polymorphism associated with side effects of deferasirox | Genetic polymorphism associated with side effects of deferasirox - Side effects: Increased AST or ALT > 5 x ULN or increased bilirubin > 3 x ULN which was thought to be caused by deferasirox Serum creatinine level increase > 50% above the baseline value. Biospecimen Retention: Samples With DNA Candidate genes exhibit polymorphisms and encodes proteins that are involved in the pharmacokinetics and pharmacodynamics of deferasirox. Candidate genes : MRP2, BCRP, UGT1A subfamily | up to 1 year |
Detecting Early Myocardial Infiltration w/Amyloid & Light Chain Deposition Disease in Multiple Myeloma Subjects

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to see if MRI techniques can be used for early evaluation of cardiac amyloidosis which is sometimes seen in individuals with multiple myeloma. Cardiac amyloidosis is a medical disorder that decreases heart function.

Detailed Description
-----------------
The purpose is to investigate the use of multiple newer CMR techniques for early evaluation of cardiac amyloidosis in multiple myeloma.

Official Title
-----------------
Role of Cardiac MR (CMR) In Detecting Features of Early Myocardial Infiltration With Amyloid and Light Chain Deposition Disease in Subjects With Multiple Myeloma

Conditions
-----------------
Multiple Myeloma

Intervention / Treatment
-----------------
* Device: Administering three additional MRI images


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All races and ethnic groups Male and female ages 18-80 years of age History of multiple myeloma CMR study for evaluation for cardiac amyloidosis Exclusion Criteria: Pregnant women Subject with a metallic or electronic or other device that could be affected by the magnet

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Additional MRI images<br>Prospective review of 100 CMR studies performed on multiple myeloma patients referred for cardiac evaluation by MRI. Three additional MRI images will be performed to determine the role of cardiac MR (CMR) in detecting features of early myocardial infiltration | Device: Administering three additional MRI images<br>* Three additional MRI images to determine the role of cardiac MR (CMR) in detecting features of early myocardial infiltration<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| This study is to see if MRI techniques can be used for early evaluation of cardiac amyloidosis which is sometimes seen in individuals with multiple myeloma. |  | The time frame is five additional minutes & three additional images during and MRI. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Light Chain Deposition Disease, Cardiac MR (CMR), Early Myocardial Infiltration, Amyloid, Multiple Myeloma
Instrument Utility for Suspected Asthma (0000-042)(COMPLETED)

Study Overview
=================
Brief Summary
-----------------
This research study was designed to help improve the diagnosis and treatment of asthma in young children. An interventional strategy using a scoring system based on risk factors and symptoms/episodes was tested to determine its ability to identify children likely to benefit from induction of asthma controller therapy at an early age. The score was derived through completion of a survey instrument referred to as the asthma risk questionnaire (ARQ). The utility of the ARQ along with the health care utilization and use of controller therapy for respiratory illnesses within one year were examined.

Official Title
-----------------
Clinical Utility of an Instrument in the Evaluation of Young Children With Suspected Asthma

Conditions
-----------------
Asthma

Intervention / Treatment
-----------------
* Behavioral: Disease Management Assessment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children less than or equal to 6 years of age who had at least 1 year prior episode of wheezing Exclusion Criteria: Children with other systemic or chronic respiratory disease and children who used an asthma controller medication with the 6 weeks prior to enrollment

Ages Eligible for Study
-----------------
Maximum Age: 6 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Disease Management Assessment|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Utility of ARQ as measured by the percentage of children started on any asthma medication and characteristics of those diagnosed with asthma |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of children with recurrent wheezing, placed on controller therapy, number of steroid courses and need for urgent medical care at 6 and 12 months |  |  |
Effectiveness of Telephone Intervention for Colorectal Cancer Caregivers

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to assess the effectiveness of the telephone intervention program for caregivers of colorectal cancer.

Detailed Description
-----------------
telephone Intervention refer to provide counseling and education to caregivers of colorectal cancer by mode of telephone

Official Title
-----------------
Effectiveness of Telephone-based Intervention on Distress, Burden and Quality of Life of Chinese Caregivers of Colorectal Cancer Patients

Conditions
-----------------
Psychological Stress

Intervention / Treatment
-----------------
* Behavioral: Telephone intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Family members with newly diagnosed colorectal cancer within the past 4 week and treated in Queen Mary Hospital Self identified as formal or informal family caregivers Over 18 years old Chinese Cantonese speaking Exclusion Criteria: Cognitive disability Domestic helpers or maids Non Chinese

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Existing care<br>routine existing care | |
| Experimental: Telephone intervention<br>in addition to provide telephone intervention support | Behavioral: Telephone intervention<br>* counseling and education support<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Distress level | Effect of telephone intervention on distress level measured at pre-discharged(baseline) and 2 weeks and 4 weeks and 8 weeks post intervention . | Change of distress level at pre-discharged(base-line) and 2 weeks and 4 weeks and 8 weeks post intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Burden of care | Effect of telephone intervention on burden of care measured at pre-discharged(baseline) and 2 weeks and 4 weeks and 8 weeks post intervention | Measured at pre-discharged(base-line) and 2 weeks and 4 weeks and 8 weeks post intervention | 
| Quality of life | Effect of telephone intervention at pre-discharged(base-line) and 2 weeks and 4 weeks and 8 weeks post intervention | Measured at pre-discharged(base-line) and 2 weeks and 4 weeks and 8 weeks post intervention | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
quality of life, anxiety, stress, carers, colorectal or colon cancer
Multidetector Computed Tomography (MDCT) Tailored Protocol

Study Overview
=================
Brief Summary
-----------------
Collection of data from different sites regardless of whether they use standard or tailored protocols for the application of high concentration iodinated contrast agents to assess if the individually patient-adapted protocols result in a similar diagnostic image quality.

Detailed Description
-----------------
To record technical information and compare image quality regarding routine MDCT procedures with contrast administration using a tailored contrast injection and radiation dose protocol. The hypotheses are that the tailored protocols lead to a lower applied mean radiation dose compared to the use of standard protocols and will provide a more standardized contrast dose per patient size without impairing diagnostic quality.

Official Title
-----------------
A Multicenter, Multinational, Randomized Study of Standard vs. Patient-Adapted Protocols in Multidetector Computed Tomography (MDCT) of the Chest, Abdomen, Liver or Aorta

Conditions
-----------------
Patients Undergoing Contrast Enhanced Multidetector Computed Tomography of the Chest, Abdomen, Liver or Aorta for Any Diagnostic Cause

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: At least 18 years of age Scheduled to undergo contrast enhanced MDCT of the abdomen, liver, aorta, or chest Provides written informed consent Exclusion Criteria: Previously enrolled and completed the study Known allergy to iodinated contrast media Pregnancy or lactation Clinically unsuitable for the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnostic Quality | Images are to be assessed according to the following scale: 0=Uninterpretable (Image quality severely affected by motion artifacts or technical reasons; need to repeat the examination); 1=Insufficient (Impaired image quality precludes adequate diagnostic assessment because of severe image noise or insufficient contrast enhancement; need to repeat the examination); 2=Adequate (Image quality in terms of noise and contrast enhancement does not interfere with sufficient diagnostic assessment; delineation of small structures may be suboptimal); or 3=Good (Absent or minimal image noise and good contrast enhancement allow adequate diagnostic assessment with clear delineation of even small structures). | Immediately after the single injection of contrast agent |
Headstrong Intervention for Pediatric Headache

Study Overview
=================
Brief Summary
-----------------
Purpose of this study is to determine if a CD-ROM computer program (called Headstrong) is effective in helping children cope with chronic headaches.

Detailed Description
-----------------
Children, 7-12 years, with recurrent headaches are randomly assigned to an educational CD-ROM program or the Headstrong CD-ROM program. We anticipate that those assigned to the active (Headstrong) program group will have significantly greater reductions in headache frequency, duration, and severity and improvements in mood and quality of life.

Official Title
-----------------
Headstrong Intervention for Recurrent Pediatric Headache

Conditions
-----------------
Chronic Headaches

Intervention / Treatment
-----------------
* Other: Educational CD-rom
* Other: Headstrong CD-rom


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: 7-12 years of age having recurrent, intermittent, nonmalignant headaches occurring on an average of at least once per week by parental or child report and separated by symptom-free periods having a diagnosis by a nurse practitioner, pediatrician, or pediatric neurologist of migraine, muscle-contraction, or chronic daily headaches Exclusion criteria: their medical history and/or neurological exam suggests that headaches are secondary to another physical or developmental condition their parents report they have been diagnosed with a mental health condition or they are receiving concurrent psychotherapy their baseline headache diaries indicate an average headache frequency of less than one per week

Ages Eligible for Study
-----------------
Minimum Age: 7 Years
Maximum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: 1<br>Educational CD-Rom | Other: Educational CD-rom<br>* Educational CD-Rom<br>|
| Experimental: 2<br>Headstrong CD-rom | Other: Headstrong CD-rom<br>* Headstrong CD-rom<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain, mood, and stress self-rating scales |  | Baseline, Immediate Post-Treatment and 3, 6 and 12 Month Follow-Up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of life |  | Baseline, Immediate Post-Treatment and 3, 6 and 12 Month Follow-Up | 
| Headache-related disability |  | Baseline, Immediate Post-Treatment and 3, 6 and 12 Month Follow-Up | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
migraine, tension headaches, chronic daily headaches
Low Literacy Intervention for Colorectal Cancer Screening

Study Overview
=================
Brief Summary
-----------------
Of 17 performance measures of hospital quality regularly reported for the Veterans Administration (VA) health care system, rates of colorectal cancer screening are the lowest.

Detailed Description
-----------------
Background: Of 17 performance measures of hospital quality regularly reported for the Veterans Administration (VA) health care system, rates of colorectal cancer screening are the lowest. Objectives: The objectives of this study were to 1) test whether a health care provider-directed intervention increased colorectal cancer screening rates in an urban VA medical center and 2) evaluate the cost-effectiveness of the intervention. Methods: The study was a randomized controlled trial, conducted at two clinic firms at a VA Medical Center in Chicago. Eligible patients were men, age 50 and older, had no personal or family history of colorectal cancer or polyps, had not received colorectal cancer screening, and had at least one visit to the clinic during the study period. Health care providers in the intervention firm attended a workshop on colorectal cancer screening. Every 4-6 months they attended quality improvement workshops where they received group screening rates, individualized confidential feedback, and training on improving communication with patients with limited literacy skills. Medical records were reviewed for colorectal cancer screening recommendations and completion. Literacy level was assessed in a subset of patients. In the cost-effectiveness analysis, resource and cost estimates were derived. Status: The project is complete.

Official Title
-----------------
Low Literacy Intervention for Colorectal Cancer Screening

Conditions
-----------------
Colorectal Cancer

Intervention / Treatment
-----------------
* Behavioral: Low Literacy Intervention for Colorectal Cancer Screening


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients over 50 with average risk for colorectal cancer. Patients with family history and/or personal history excluded, as well as those up to date on colorectal cancer screening. Exclusion Criteria:

Ages Eligible for Study
-----------------
Minimum Age: 50 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Arm 1<br> | Behavioral: Low Literacy Intervention for Colorectal Cancer Screening<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |