Propofol or Midazolam for Sedation and Early Extubation Following Coronary Artery Bypass Graft Surgery

Study Overview
=================
Brief Summary
-----------------
Propofol and midazolam are used frequently as sedating agents among patients who undergo coronary artery bypass graft surgery but no study in Pakistan has been done to compare their effectiveness aiming early extubation.

Detailed Description
-----------------
Propofol is an intra lipid and alkali phenol chemically it is unrelated to sedative agents or anaesthetic. Midazolam is a banzodiazepen. Most of its properties are similar to diazepam. It is a common practice to use sedatives to provide comfort and decrease ventilator-asynchrony in critically ill patients that may require prolonged invasive mechanical ventilation. The other reason to employ sedatives is to reduce the anxiety associated with the inaviseve procedures routinely conducted in the ICU.

Official Title
-----------------
Propofol or Midazolam for Sedation and Early Extubation Following Coronary Artery Bypass Graft Surgery

Conditions
-----------------
Coronary Artery Disease

Intervention / Treatment
-----------------
* Drug: Midazolam


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients of American Society of Anesthesiologists (ASA) III who were selected for coronary artery bypass graft surgery. Exclusion Criteria: History of any psychiatric disease. Using antidepressants Alcohol abusers Obese Pregnant women

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Radomized Controlled Trial
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: MIdazolam Group<br>Following surgery Immediately after shifting in ICU, midazolam infusion were administered as 0.25 mg/kg/min. | Drug: Midazolam<br>* Midazolam infusion will be given after the surgery as 0.25 mg/kg/min.<br>* Other names: Versed;|
| No Intervention: Propofol Group<br>Following surgery after Immediately shifting in ICU propofol infusion was started at 10µg/kg/min. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of post-surgery sedation | Duration of post-surgery sedation following cardiac surgery | Time in minutes calculated from end of surgery to the time of awakening up to 24 hours in both study groups | 
| Time taken to post-surgery extubation | Time taken from the end of cardiac surgery to post-surgery extubation | Time taken in minutes from the end of the cardiac surgery to post-surgery extubation up to 1 week duration in both study groups | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
coronary artery bypass graft, propofol, midazolam