Biomarkers Correlation With Volemia

Study Overview
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Brief Summary
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The purpose of this study is to determine whether the Biomarkers (pro adrenomedullin (MR proADM), pro arginin vasopressin (CT proAVP), pro atrial natriuretic peptid (MR proANP), Pro Endothelin) changes at Day 2, Day 5 and Day 7 of ICU admission are correlated with Intravascular volume assessed by Cr 51 on red blood cells (Day 2 and Day 7) and by I 125 on albumine Day 7. The correlation of these Biomarkers are also evaluted with other markers such as erythropoietin and catecholamines. 80 ICU patients are included.

Official Title
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Predictive Value of Biomarkers on Volemia, Extra and Intra Vascular Varation and Hydroelectrolytic Disorders in Different ICU Patients

Conditions
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Cerebral Hemorrhage, Head Injury, Non Traumatic Post Surgery, Poly Trauma Patients Without Heart Failure, Renal Insufficiency

Intervention / Treatment
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* Other: Biomarkers, red blood cells and plasma assessment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 20 Cerebral Hemorrhage 20 Head Injury 20 post surgery non traumatic non neuro 20 Polytrauma patients Exclusion Criteria: Heart failure NYHA III or IV Renal insufficiency creatinin clearance < 30 ml/mn age < 18 Y Pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Biomarkers, total blood volume<br> | Other: Biomarkers, red blood cells and plasma assessment<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Predictive value of biomarkers changes in Volemia variation | Correlation with total blood volume(assessed by Cr 51) and biomarkers(Mr proADM, Mr proANP, CT proAVP and proendothelin)changes | at Day 2, Day 5 and Day 7 of ICU admission | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Predictive value of biomarkers changes with efficient volemia, fluid managements and other Markers such erythropoietin | Correlation with efficient volemia and Biomarkers ( Mr proADM, Mr proANP, CT proAVP and proendothelin)changes. | at Day 2, Day 5 and Day 7 of ICU admission | 
| Predictive value of Biomarkers with APACHE II and SOFA score and Prognosis at ICU discharge | Correlation of Biomarkers changes with APACHE II and SOFA score and Mortality at Day 2, Day 5 and Day 7 of their ICU admission and at ICU discharge. | at Day 2 , Day 5 and Day 7 of ICU admission and at discharge | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ProADM, ProANP, proendothelin, proAVP, Cr 51, Volemia, fluid management, ICU patients, poly trauma patients