Effectiveness of Ultrasound (US) Guided Supraclavicular Block

Study Overview
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Brief Summary
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This research study is being done in order to find out if there is any difference in the effectiveness of ultrasound guided supraclavicular brachial plexus nerve block that can be achieved with 3 different amounts of ropivacaine 0.5% (20 ml, 30 ml, and 40 ml). The investigators want to show if you can have a successful nerve block with less amount of local anesthetic, thus potentially decreasing the risk of side effects.

Official Title
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Effectiveness of Ultrasound Guided Supraclavicular Brachial Plexus Block With 20, 30, or 40 ml of Ropivacaine 0.5%

Conditions
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Analgesia, Pain

Intervention / Treatment
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* Drug: 20 ml of ropivacaine 0.5%
* Drug: 30 ml of ropivacaine 0.5%
* Drug: 40 ml of ropivacaine 0.5%


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients between the ages of 18-64, Patients who are ASA I-III, presenting for distal upper extremity surgery. Surgeries to be considered are ORIF of distal upper extremity fractures such as ORIF radius, ORIF ulna, ORIF of any bones in the wrist or hand, and distal upper extremity surgery involving bones or tendons for which postoperative pain is to be expected. No emergency surgeries will be considered. Exclusion Criteria: Emergency surgery, Patient or surgeon refusal Patients for which peripheral nerve block or study medications are contraindicated, Patients on chronic analgesic therapy at home, History of nerve injury, neuropathy, or known neurologic injury or illness, or inability to properly describe postoperative pain to investigators (language barrier, psychiatric disorder, dementia).

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 64 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group R20<br>Patient will receive 20 ml of ropivacaine 0.5% for their ultrasound guided supraclavicular block. | Drug: 20 ml of ropivacaine 0.5%<br>* Patient will receive 20 ml of ropivacaine 0.5% for their ultrasound guided supraclavicular block.<br>|
| Active Comparator: Group R30<br>Patient will receive 30 ml of ropivacaine 0.5% for their ultrasound guided supraclavicular block. | Drug: 30 ml of ropivacaine 0.5%<br>* Patient will receive 30 ml of ropivacaine 0.5% for their ultrasound guided supraclavicular block.<br>|
| Active Comparator: Group R40<br>Patient will receive 40 ml of ropivacaine 0.5% for their ultrasound guided supraclavicular block. | Drug: 40 ml of ropivacaine 0.5%<br>* Patient will receive 40 ml of ropivacaine 0.5% for their ultrasound guided supraclavicular block.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Onset of analgesia |  | First 30 minutes | 
| Duration of analgesia |  | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total analgesic use |  | First 24 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Anesthesia