Subjective Perception of Motor Control During Psychogenic Disorders

Study Overview
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Brief Summary
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The aim of this study is to reveal neurobiological bases of the motor control of conscious perception, thanks to new techniques of functional cerebral imaging (MRI), and potentials deteriorations connected to neuropsychiatric disorders like conversion disorder. The Hospital University Center of Grenoble will provide patients from Neurology department, characterized with non psychogenic epileptic seizures and abnormal psychogenic movements, from conversive origin. Subjects will be scanned by Magnetic Resonance Imaging during a motor paradigm inducing a perceptive conflict between two informations : proprioceptive information coming from the action (drawing) and visual information (draw's mark) that appears on the screen when there is movement.

Detailed Description
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New results will be provided about brain mechanisms involved in motor control perception among healthy patients and patients suffering from functional neurologic symptoms.

Official Title
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Study of Subjective Perception of Motor Control During Psychogenic Disorders : Brain Mechanisms and Functional Imaging.

Conditions
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Somatoform Disorders

Intervention / Treatment
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* Other: functional brain MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Signed informed consent Medical exam médical done before study participation Between 18 and 65 years Right-handed persons Conversion disorder based on DSM IV-R criterias Symptom affecting motor system, like abnormal movements (shivers, dystonia, parkinsonism, or problem when walking) Exclusion Criteria: Subjects included in a clinical and/or therapeutic exeprimentation in progress People with MRI contraindications : prosthesis or metal implants, metallic teeth (dental) brace, pacemaker, IUD, possibility of pregnancy, claustrophobia Traitement médicamenteux psychotrope ou susceptible d'interférer avec le débit sanguin cérébral ou l'activité neuronale History of brain or disseminated and extendible lesions of white matter, of an other degenerative morbidity, a confusion or an insanity as well as serious deficits preventing language understanding. Alcohol ingestion Pregnant, parturient or breastfeeding women All other categories of protected persons

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Psychogenic disorders<br>Psychogenic movement disorders and seizures | Other: functional brain MRI<br>* functional imagery during motor-perception tasks<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Familiarization with the joystick. | HHSC-JOY-I from Current Designs. They are asked to trace a straight line. | 30 minutes | 
| Brain MRI |  | One hour and a half | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Somatoform, Psychogenic