Greater Occipital and Supraorbital Nerve Blockade in Migraine Patients

Study Overview
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Brief Summary
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The investigators aimed to evaluate the efficacy of greater occipital nerve and supraorbital nerve blockade with local anesthetics for the preventive treatment of migraine without aura.

Detailed Description
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A mixture of 1 ml 2% lidocaine and 0.9% 1 ml saline was injected bilaterally to GON and SON in the blockade patients. Placebo patients received 2 ml 0.9% saline in the same way. Patients were blinded to kind of injection.

Official Title
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Greater Occipital and Supraorbital Nerve Blockade For The Preventive Treatment of Migraine

Conditions
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Migraine Disorders

Intervention / Treatment
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* Procedure: Lidocaine injections
* Procedure: Saline injections


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Lack of benefits 1 year from preventive treatment or intolerance to their treatments. 18 ≥ years old Migraine without aura for more than 1 year, minimum of two or more migraine attacks per month. Exclusion Criteria: Patients with any chronic illness, medication overuse headache, a history of cranial and cervical surgery Allergies to local anesthetics Hemorrhagic diathesis Alcohol or drug abuse

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Blockade Group<br>Lidocaine injections. Procedure. Grater occipital nerve and supraorbital nerve were blocked with %2 lidocaine. These injections were repeated weekly for three weeks. After treatment was completed, patients were followed up for 2 months at the polyclinic to assess the clinical response. | Procedure: Lidocaine injections<br>* Lidocaine injections. A mixture of 1 ml 2% lidocaine and 0.9% 1 ml saline was injected bilaterally to greater occipital nerve and supraorbital nerve in the blockade patients.<br>|
| Placebo Comparator: Placebo Group<br>Saline injections. Procedure. Grater occipital nerve and supraorbital nerve were injected with saline.These injections were repeated weekly for three weeks. After treatment was completed, patients were followed up for 2 months at the polyclinic to assess the clinical response. | Procedure: Saline injections<br>* Saline injections. Patients received 2 ml 0.9% saline in bilaterally to greater occipital nerve and supraorbital nerve<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of Frequency of Headache | Number of headache days in a month. Scores from both months were averaged. Minimum=0 Maximum=30. Lower scores mean a better outcome. | Patients were followed up from baseline to 2 months after first injection. | 
| Change of Severity of Headache | Mean visual analog scale (VAS) scores. Scores from both months were avareged. Minimum=0 Maximum=10. Lower scores mean a better outcome | Patients were followed up for 2 months from baseline after first injection. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pain, Nerve Blocks, Headache, Local Anaesthetics, Migraine