Applied The Platelet Rich Fibrin in Chronic Periodontitis

Study Overview
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Brief Summary
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Platelet rich fibrin is a second generation platelet concentration which contains various growth factors. The aim of this study is to evaluate the clinical and biochemical efficacy of PRF in subjects of chronic periodontitis in the operation of conventional periodontal flap.

Detailed Description
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PRF was developed in 2001 by Choukroun in France, it was the second generation fibrin adhesive, and was used to accelerate the soft and hard tissue healing. Many studies have shown beneficial effects of PRF on osteoconductive filler material in sinus lift operations, treatment of periodontal sulcus defect and treatment of furcation defects. Also PRF contains many growth factors. PRF accelerates periodontal regeneration through the gradually excreted growth factors and contributes to the bone regeneration. In this study, the investigators evaluated the effect of PRF on growth factors and its contribution to periodontal regeneration in subjects with chronic periodontitis.

Official Title
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Investigation of the Contributions of Platelet Rich Fibrin Combined With Conventional Periodontal Flap on Periodontal Healing

Conditions
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Chronic Periodontitis

Intervention / Treatment
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* Device: Platelet Rich Fibrin
* Device: Conventional Flap Surgery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with CP who had pocket depth ≤ 5 mm and at least two area (grouped as Control and PRF) with horizontal bone loss after Phase I therapy Exclusion Criteria: The subjects excluded in the study had history of systemic disease, were smokers, had allergy to any drug, had need for prophylaxis of antibiotic and had taken antibiotics at least 6 months
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Platelet Rich Fibrin<br>Platelet Rich Fibrin was applied with conventional flap surgery for treatment of periodontal bone loss in test group. | Device: Platelet Rich Fibrin<br>* Platelet rich fibrin increases the growth factors. So it was applied for treatment of periodontal bone loss.<br>|
| Active Comparator: Conventional Flap Surgery<br>Platelet Rich Fibrin was not applied to control groups. Only conventional flap surgery was applied to control groups. | Device: Conventional Flap Surgery<br>* Only Conventional Flap Surgery treatment the bone loss limitedly.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Levels of IGF-1, VEGF, BMP-2, FGF-2 on Weekly | Change from baseline IGF-1, VEGF, BMP-2, FGF-2 levels of GCF at 1 month were measured by periopaper. | 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Alteration of Clinical Attachment Level | Change from baseline Clinical Attachment Levels at 6 months were measured with periodontal probe. | 6 month | 
| Alteration of Periodontal Pocket Depth | Change from baseline Pocket Depth at 6 months were measured with periodontal probe. | 6 month |