Comparison of Desflurane With Sevoflurane for School-age Children in Postoperative Cognitive Function

Study Overview
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Brief Summary
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This study compares desflurane with sevoflurane for school-age children in postoperative cognitive function.

Detailed Description
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The postoperative cognitive dysfunction (POCD) of school-age children (6-14 age) after operation draw more attention from both society and family. It is well known that, compare with sevoflurane, desflurane could improve cognitive function in elderly patients. But whether Desflurane could improve postoperative cognitive function compare with Sevoflurane for the school-age children, there is no consistent conclusion.

Conditions
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Postoperative Cognitive Dysfunction

Intervention / Treatment
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* Drug: Desﬂurane
* Drug: sevoﬂurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 6-14 age, elective no-cardiac and non-neurological surgery , ASA physical statusⅠorⅡ, no preoperative cognitive function impairment, cooperate to complete the entire test. Exclusion Criteria: Allergic to halogens inhaled anesthetics, malignant hyperthermia susceptible patients, intracranial hypertension, emotional disorder, hyperactivity, history of operation, mental retardation, audio-visual obstacles, history of congenital heart disease, Important organ dysfunction, history of drug abuse History of epilepsy Preoperative respiratory infection significantly.

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 14 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Group Desflurane<br>Anesthesia maintenance: After endotracheal intubation, patients will be randomized into Desﬂurane for maintenance. The gas flow rate of Desflurane group is 2 L/min, include 50％ O2 and 4～5％ Desflurane. | Drug: Desﬂurane<br>* Anesthesia maintenance: After endotracheal intubation, half of the patients will be randomized into Desﬂurane Group. The gas flow rate of Desflurane group is 2 L/min, include 50％ O2 and 4～5％ Desflurane.<br>|
| Active Comparator: Group Sevoflurane<br>Anesthesia maintenance: After endotracheal intubation, patients will be randomized into sevoﬂurane for maintenance. The gas flow rate of Sevoflurane group is 2L/ min, include 50％O2 and 1.7-2.0% Sevoflurane. | Drug: sevoﬂurane<br>* Anesthesia maintenance: After endotracheal intubation, half of the patients will be randomized into Sevoﬂurane Group. The gas flow rate of Desflurane group is 2 L/min, 50％O2 and 1.7-2.0% Sevoflurane.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The incidence of postoperative cognitive dysfunction | Cognitive function score should be carried out for all children at preoperative 1d, postoperative 2 d, 3d and 7d. If postoperative score compared with preoperative score drop 1 points or more, then postoperative cognitive dysfunction will be recorded. | Within 7 days after operation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| age | years old | 1 day before operation | 
| male | If the child is boy,it's yes,or it's no. | 1 day before operation | 
| height | CM | 1 day before operation | 
| weight | kg | preoperation | 
| previous operation history | If the child had previous operation history,it's yes,or it's no. | preoperation | 
| the duration of anesthesia | minutes | From the time began to give the anesthetic to the time of pull out the endotracheal intubation | 
| the duration of operation | minutes | Surgery end time minus the start time | 
| total blood loss | ml | The total blood loss of the whole surgery time. | 
| total volume of infusion | ml | The total volume of infusion of the whole surgery time. | 
| whether there is respiratory depression in postanesthesia care unit | If the child has respiratory depression during this time,it's yes,or it's no. | The period which the patient stay at post anesthesia care unit,from the time enter to postanesthesia care unit to the time leave postanesthesia care unit,the estimated period is up to 30 minutes. | 
| the length of hospital stay | days | the time from admission to hospital to discharge from hospital,the estimated period is up to 5 days. | 
| S100β | obtain the children's plasma to detection S100β with ELEASE. | 1 day after surgery | 
| NSE | obtain the children's plasma to detection NSE with ELEASE. | 1 day after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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desflurane, sevoflurane