Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke With Mild Symptoms

Study Overview
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Brief Summary
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Mechanical thrombectomy(MT) has been recommended in patients with acute large vessel occlusion stroke(LVO) , especially for those with National Institutes of Health Stroke Scale (NIHSS) score ≥6. However, it is still unclear if patients with minor strokes and LVO also benefit from MT.The aim of this study was to evaluate the safety and efficacy of MT for acute LVO and mild symptoms.

Detailed Description
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This is a prospective cohort study of patients with with mild ischemic stroke (NIHSS Score <6) and LVO. Patients were divided into 2 groups: MT or medical management.Baseline data and clinical outcomes were compared. A independent clinical outcome was defined as a modified Rankin Scale score of 0 to 2 at 90 days. A excellent clinical outcome was defined as a modified Rankin Scale score of 0 to 1 at 90 days. Symptomatic intracranial hemorrhage(sICH) was the safety outcome.

Official Title
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Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke With Mild Symptoms After Imaging Selection

Conditions
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Acute Stroke, Ischemic Stroke

Intervention / Treatment
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* Procedure: Mechanical Thrombectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: acute ischemic stroke within 24 hours of symptom onset presenting cortical symptoms (such as aphasia, somnolence,slow-minded,etc.) or vertigo with bilateral pathological signs; age≥18 years old; the NIHSS score before evaluation of thrombectomy<6; large artery occlusion including Middle cerebral artery M1, proximal M2 segment, intracranial internal carotid artery and infarct core volume≤50ml and mismatch ratio>1.8 or basilar artery and posterior cerebral artery P1 occlusion Exclusion Criteria: Patients without prior functional independence (mRS score of >2) Patients in intervention group with occlusive artery spontaneous recanalization in digital subtraction angiography patients in control group with neurological worsening and received rescue thrombectomy

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: A prospective, non-randomized, controlled, outcome-blinded study
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention group<br>patients in this group will receive mechanical thrombectomy and standardized drug treatment of acute ischemic stroke | Procedure: Mechanical Thrombectomy<br>* Solitaire stent and manual aspiration thrombectomy were performed as the first-line endovascular treatment<br>|
| No Intervention: control group<br>patients in this group will receive standardized drug treatment of acute ischemic stroke | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| modified Rankin Scale(mRS) score of 0 to 2 | independent outcome at 90 days | 90 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| modified Rankin Scale(mRS) score of 0 to 1 | excellent outcome at 90 days | 90 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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thrombectomy, acute ischemic stroke, acute large vessel occlusion, mild stroke;, prognosis