Calcium Metabolism in Mexican American Adolescents

Study Overview
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Brief Summary
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The purpose of this study is to identify calcium metabolism characteristics in Mexican American adolescents. The investigators predict that calcium requirements to maximize bone health in this population will be lower than for white youth but higher than their current intakes.

Detailed Description
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Previously significant racial and sex differences in calcium retention and kinetics in adolescents has been found. Other minority groups have increased calcium absorption efficiency at low calcium intakes in contrast to white adolescents. Since Hispanics and specifically Mexican Americans will soon comprise an increasing proportion of our population. We propose to identify calcium metabolism characteristics in this group. We predict that calcium requirements to maximize bone health in this population will be lower than for white youth but higher than their current intakes. Thus the specific aims of this project include: to establish calcium requirements to establish the relationship between calcium intake and calcium absorption to identify the major physiological parameters(kidney, intestine, bone) that contribute to calcium retention in Mexican-American adolescents During this two-phase metabolic camp participants will consume either a higher calcium diet(1100-2300mg/d) or a lower calcium diet (600-1200mg/d) during the first 3-week phase and switch to the opposite regime during the second 3-week phase, with a 2-week washout period in between. Subjects will collect all excreta during both phases. Calcium absorption, height, weight, and bone density will evaluated throughout the 6-week period of the study.

Official Title
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Calcium Metabolism in Mexican American Adolescents

Conditions
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Osteoporosis

Intervention / Treatment
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* Dietary Supplement: Low Calcium Diet
* Dietary Supplement: High Calcium Diet


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Normal, healthy adolescents of Mexican American descent Mexican American boys age 13-15 Mexican American girls age 12-14 Exclusion Criteria: Malabsorptive disorders Anemia Smoking History of medications known to affect calcium metabolism Body weight outside 85-120% of ideal body weight for height Regular consumption of illegal drugs Contraceptive use Pregnancy

Ages Eligible for Study
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Minimum Age: 12 Years
Maximum Age: 15 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Low Calcium Diet (600-1200 mg/d)<br> | Dietary Supplement: Low Calcium Diet<br>* The basal diet will contain 600 mg of Ca per day and constant sufficient amounts of all other nutrients. Additional Ca will be given unfortified beverages served three times per day. Teens will be randomized to a lower (600-1200 mg/d)level of calcium in the first camp followed by the opposite (higher calcium diet)regime in the second camp.<br>|
| Active Comparator: High Calcium Diet (1100-2300mg/d)<br> | Dietary Supplement: High Calcium Diet<br>* The basal diet will contain 600 mg of Ca per day and constant sufficient amounts of all other nutrients. Additional Ca will be given unfortified beverages served three times per day. Teens will be randomized to a higher (1100-2300mg/d)level of calcium in the first camp followed by the opposite (lower calcium diet)regime in the second camp.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Calcium Absorption and Retention |  | June 2010-July 2010 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bone Density |  | June 2010-July 2010 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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calcium, healthy, Mexican-American adolescents, camp, girls, boys, bone