Effects of Multidisciplinary Interventions in Elderly Asthma Patients With Risk of Acute Exacerbation

Study Overview
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Brief Summary
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We want to examine the effect of multidisciplinary interventions in asthma patients who had experienced acute exacerbation of asthma. In our previous observational studies, elderly asthma patients had a some distinct features such as impairment of cognitive function, deficiency of micronutrient and absence of caregiver compared with young adult asthmatics. We wanted to evaluate whether the long-term course of asthma could be modified by intervening deficienies which were found in elderly patiensts. So, we designed a interventional study to correct above risk factors in elderly asthma patients, which could be aggravating their asthma. Followings are our specific multidiciplinary items that we want to correct. popularize and educate the asthma action plan run a emergency call system for acute exacerbation educate the proper techniques using inhalers correct the deficiency of magnesium (magnesium 500 mg per day) After 1 years, we will measure the numbers of acute exacerbations, lung function including FEV1 and FEV1/FVC, health-related quality of life and level of serum magnesium in study patients.

Conditions
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Asthma, Aged

Intervention / Treatment
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* Dietary Supplement: Magnesium
* Behavioral: Education for asthma action plan
* Behavioral: hot-lines for acute exacerbation of asthma
* Behavioral: Inhaler technique training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: elderly asthma patients who had experienced acute exacerbation of asthma 1)aggravations of any of major criteria dyspnea cough wheezing increase or purulent changes of sputum nocturnal symptoms 2)aggravation of more than one of following criteria a reduction of forced expiratory volume at one second or peak expiratory flow rate more than 20% compared than one's best score unscheduled clinic or emergency department visit or admission step-up of dose of asthma medications or any intake of systemic steroids

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention<br>We designed a intervention study to correct additional risk factors in elderly asthma patients. We offer following specific interventions simultaneously to intervention arm and will measure the effects of interventions after 1 years. popularize and educate the asthma action plan run a emergency call system for acute exacerbation educate the proper techniques using inhalers correct the deficiency of magnesium (magnesium 500mg per day) | Dietary Supplement: Magnesium<br> <br> * Other names: Company - Daewha pharmaceutical;Behavioral: Education for asthma action plan<br> <br> Behavioral: hot-lines for acute exacerbation of asthma<br> <br> Behavioral: Inhaler technique training<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of acute exacerbation of asthma | measure the existence of acute exacerbation when they visit the clinic at 3, 6, 12 month after enrollment | 1 year from enrollment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pulmonary function test | measure when subjects visits the clinic at 3, 6, 12 month after enrollment | 1 year after enrollment | 
| Asthma control status | measure when subjects visit the clinic at 3, 6, 12 month after enrollment | one year from enrollment | 
| asthma quality of life questionnaire | measure when subjects visit the clinic at 3, 6, 12 month after enrollment | one year from enrollment | 
| serum magnesium level | measure when subjects visit the clinic at 3, 6, 12 month after enrollment | one year from enrollment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Acute exacerbation, Quality of life, Magnesium deficiency, Multidisciplinary intervention