Whole Body Vibration - a New Therapeutic Approach to Improve Muscle Function in CF

Study Overview
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Brief Summary
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The purpose of this study is to evaluate the effects of whole body vibration (WBV) on muscle function in adult CF-patients.

Detailed Description
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Cystic Fibrosis (CF) is the most common chronic hereditary disease in Caucasians. Due to improved therapy and better understanding of the disease, life expectancy has risen to an average of 38 years and is continuing to rise. With the increased life-expectancy it becomes even more important to maintain functional activity as part of quality of life. Mechanical stimulation in form of whole body vibration (WBV) is a new type of exercise currently tested in sports, geriatrics and rehabilitation. It has recently been found to be a safe and efficient method to activate muscular activity via stretch reflexes leading to improvement of muscular performance, body balance and physical functioning. 10 patients of the CF Center Cologne, Germany, took part in the Galileo study. They were provided by the vibrating platform (Galileo 2000)for whole body vibration training at home. The patients were standing in an upright position receiving vertical vibration of frequencies between 20-25 Hz. This vibration exercise evokes muscle contractions via stretch reflexes improving muscular activity. The training schedule consisted of three 3-minute sessions twice a day 5 days per week for 3 months. Every 4 weeks the patients were seen for assessment of muscle function to evaluate the effects of this new intervention.

Official Title
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Cystic Fibrosis: Improvement of Muscle Force and Function by Whole Body Vibration Exercise

Conditions
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Cystic Fibrosis

Intervention / Treatment
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* Device: GALILEO


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: clinical diagnosis of Cystic Fibrosis age older than 18 years Exclusion Criteria: hypersplenic syndrome acute arthritis or osteomyelitis

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: GALILEO|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| muscle force at the beginning of the study and after 3 months |  |  | 
| muscle power at the beginning of the study and after 3 months |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pulmonary function testing at the beginning of the study and after 3 months |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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whole body vibration, muscle function, cystic fibrosis, mechanography, chair-rising-test