High-resolution Imaging of Corneal Lesions With Optical Coherence Tomography (OCT) - A Pilot Study

Study Overview
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Brief Summary
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Corneal lesions such as corneal abrasions and corneal infiltrates are common in clinical practice. The current study seeks to investigate whether high-resolution OCT is suitable for imaging of these corneal lesions. The present study has the character of a pilot study and the results are intended to be used to develop a standardized protocol for imaging and analysis of these corneal lesions. Based on this protocol, further studies investigating the pathophysiology of corneal lesions or evaluating therapeutic success can be planned.

Official Title
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High-resolution Imaging of Corneal Lesions With Optical Coherence Tomography (OCT) - A Pilot Study

Conditions
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Corneal Abrasions, Corneal Infiltrates

Intervention / Treatment
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* Device: Optical Coherence Tomography (OCT)
* Other: Slit lamp biomicroscopy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men and women aged over 18 years Newly diagnosed corneal abrasion or corneal infiltrate Exclusion Criteria: Recurrent corneal erosion Participation in a clinical trial in the previous 3 weeks Presence of any abnormalities preventing reliable measurements as judged by the investigator Any contraindication for topical application of Novain 0.4% eye drops for topical anesthesia or of Minims-Fluorescein Sodium eye drops for fluorescein staining Pregnancy, planned pregnancy or lactating

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 10 patients with corneal abrasions<br> | Device: Optical Coherence Tomography (OCT)<br>* High-resolution OCT imaging of the cornea<br>Other: Slit lamp biomicroscopy<br>* Slit lamp biomicroscopy with fluorescein staining and slit lamp photograph<br>|
| Experimental: 10 patients with corneal infiltrates<br> | Device: Optical Coherence Tomography (OCT)<br>* High-resolution OCT imaging of the cornea<br>Other: Slit lamp biomicroscopy<br>* Slit lamp biomicroscopy with fluorescein staining and slit lamp photograph<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Imaging of corneal abrasions and infiltrates | The aim of this pilot study is to investigate whether imaging of these corneal alterations is possible. | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Size and depth of corneal lesions as assessed with high-resolution OCT | The volume and size of corneal lesions or infiltrates will be assessed using a specific software. | 1 day | 
| Slit lamp biomicroscopy with fluorescein staining | The volume and size of corneal lesions or infiltrates will be assessed. | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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optical coherence tomography, corneal abrasion, corneal infiltrate