The Effect of Sugammadex Given Based on Ideal, Actual or Adjusted Body Weight on Reversal of Rocuronium.

Study Overview
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Brief Summary
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The aim of this study is compare the reversal of rocuronium induced neuromuscular blockade in morbidly obese patients using three doses of sugammadex; based on ideal body weight, adjusted body weight, and actual body weight.

Detailed Description
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The aim of this study is compare the reversal of rocuronium induced neuromuscular blockade in morbidly obese patients using three doses of sugammadex; based on ideal body weight, adjusted body weight, and actual body weight. Reversal Time: time from administration of Sugammadex to train of four (TOF) ratio ≥ 0.9 will be used as primary outcome. Time need for extubation (time from administration of sugammadex to extubation), and duration of stay in post anesthesia care unit (PACU), will be used as secondary outcome.

Official Title
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The Effect of Sugammadex Given Based on Ideal, Actual or Adjusted Body Weights on Reversal of Neuromuscular Blockade in Morbidly Obese Patients Undergoing Laparoscopic Bariatric Surgery

Conditions
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Muscle Relaxation

Intervention / Treatment
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* Drug: Sugammadex


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients older than 18 years and under 45 years, body mass index ≥ 40 kg/m2, with indication of bariatric surgery Exclusion Criteria: Patients with comorbid including: neuromuscular disease, renal impairment, and patients with difficult airway were excluded from this study.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Group A<br>Sugammadex given in a dose of 2mg/kg based on ideal body weight | Drug: Sugammadex<br>* sugammadex given based on 3 measurements of body weights<br>* Other names: bridion;|
| Experimental: Group B<br>Sugammadex given in a dose of 2mg/kg based on adjusted body weight | Drug: Sugammadex<br>* sugammadex given based on 3 measurements of body weights<br>* Other names: bridion;|
| Experimental: Group C<br>Sugammadex given in a dose of 2mg/kg based on actual body weight | Drug: Sugammadex<br>* sugammadex given based on 3 measurements of body weights<br>* Other names: bridion;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reversal Time | Reversal Time: time from administration of Sugammadex to train of four (TOF) ratio ≥ 0.9 will be used as primary outcome. | 5 minutes after sugammadex administration | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| duration of stay in PACU | period of stay in the PACU | 60 minutes after admission to the PACU | 
| Time need for Extubation | time from administration of sugammadex to extubation | 10 minutes after sugammadex administration | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Sugammadex, morbidly obese patients, bariatric surgery, neuromuscular blockade