Clinical Utility of an Age, Sex, and Gene Expression Score (ASGES or Corus CAD) in African American Patients.

Study Overview
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Brief Summary
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This is a retrospective study, designed to be conducted at a single-center in the US. The study will conduct a one-time data abstraction from approximately 500 patient medical charts who received Age/Sex/Gene Expression score (ASGES) also knows as Corus CAD testing, by order of the Principal Investigator. Limited demographic data and patient data pertaining to cardiology referral or advanced diagnostic testing will be collected. All data will be collected anonymously.

Detailed Description
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Though the diagnostic properties of Age/Sex/Gene Expression Score (ASGES) or Corus CAD have been evaluated in previous observational studies, there are limited data regarding how primary care clinicians are using the results of the test in the care and management of patients with symptoms suggestive of angina in the African-America patient population. This retrospective study is designed to examine the relationship between the Corus CAD (ASGES) score and patterns of care regarding cardiology referral or further cardiac diagnostic testing in an African-American patient population single-center site. This is a retrospective study, designed to be conducted at a single-center in the US. The study will conduct a one-time data abstraction from approximately 500 patient medical charts who received Corus CAD (ASGES) testing, by order of the Principal Investigator. Limited demographic data and patient data pertaining to cardiology referral or advanced diagnostic testing will be collected. All data will be collected anonymously. IRB approval will be requested with a waiver of informed consent, as no identifying information will be collected. This retrospective study is designed to understand the patterns of care, including referrals for cardiac care and testing (including referrals to a cardiologist, exercise stress testing, cardiac computerized tomography angiography (CCTA), invasive cardiac angiography (ICA)) within an African-American patient population.

Official Title
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Clinical Utility of an Age, Sex and Gene Expression Score (ASGES or Corus CAD) in the Diagnostic Management of Obstructive Coronary Artery Disease in African American Patients in a Primary Care Setting

Conditions
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CHD, Coronary Artery Disease, Angina Pectoris, Chest Pain, Cardiovascular Diseases, Coronary Heart Disease, CVD, CAD

Intervention / Treatment
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* Diagnostic Test: Corus CAD (ASGES)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients receiving Corus CAD (ASGES) from 2008-2012. Exclusion Criteria: If any of the following co-moribidities, medical conditions, or current medical statuses are noted in the patient medical chart, s/he will be excluded from the analysis dataset: History of diabetes; Revascularization or myocardial infarction; Systemic infection or inflammatory condition; or Use of steroids, immunosuppressive agents, or chemotherapeutic agents.

Ages Eligible for Study
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Minimum Age: 21 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Treatment Group<br>Patients receiving Age/Sex/Gene Expression Score (ASGES) or Corus CAD test | Diagnostic Test: Corus CAD (ASGES)<br>* Age/Sex/Gene Expression Score - ASGES<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Referral rate of patients receiving Age/Sex/Gene Expression Score (ASGES) or Corus CAD | Referral rate of patients receiving Age/Sex/Gene Expression Score (ASGES) or Corus CAD , expected follow-up up to 1 year | Expected follow-up up to 1 year after receiving Corus CAD testing | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Corus CAD, Personalized Medicine, CAD, ASGES, Age/Sex/Gene Expression Score, GES, CVD, CHD, Precision Medicine, Clinical Utility, Gene Expression, Coronary Heart Disease, Cardiovascular Disease, Chest Pain, Coronary Artery Disease, Angina Pectoris, exercise stress testing, CT angiography, invasive cardiac angiography, African-American patient, ICA, CTA