Olfactory and Visual Perception in Depressed Patients

Study Overview
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Brief Summary
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The study aimed to determine the emotional reactivity of depressed patients to visual and olfactory stimuli in comparison with healthy volunteers.

Official Title
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Study of the Emotional Reactivity to Olfactive and Visual Perception in Depressed Patients

Conditions
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Depression

Intervention / Treatment
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* Behavioral: olfactory assessment
* Behavioral: image visualization
* Behavioral: psychophysiological assessment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: no cognitive impairment that could prevent instruction comprehension no more than 10 cigarettes/day signed informed consent group 1: current major depressive disorder group 2: no current major depressive disorder Exclusion Criteria: pregnancy visual impairment olfactory impairment

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: depressed patients<br>patient with a current unipolar major depressive disorder intervention: olfactory assessment, image visualization and psychophysiological assessment | Behavioral: olfactory assessment<br>* determination of olfactory sensitivity through olfactory threshold assessment (butanol) determination of hedonicity and intensity of 16 usual odors<br>Behavioral: image visualization<br>* 20 images (from the IAPS-international affective picture systems) are presented to the subject. He has to determine the hedonicity of each picture.<br>Behavioral: psychophysiological assessment<br>* during the olfaction assessment and the image visualization, skin conductance reactivity (SCR) is recorded to assess unconscious emotional reactivity<br>|
| Experimental: non depressed subject<br>subject without a current unipolar major depressive disorder intervention: olfactory assessment, image visualization and psychophysiological assessment | Behavioral: olfactory assessment<br>* determination of olfactory sensitivity through olfactory threshold assessment (butanol) determination of hedonicity and intensity of 16 usual odors<br>Behavioral: image visualization<br>* 20 images (from the IAPS-international affective picture systems) are presented to the subject. He has to determine the hedonicity of each picture.<br>Behavioral: psychophysiological assessment<br>* during the olfaction assessment and the image visualization, skin conductance reactivity (SCR) is recorded to assess unconscious emotional reactivity<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hedonicity score of visual stimuli | it will be compared between depressed and non depressed subjects. | up to 1 month | 
| skin conductance reactivity amplitude | it will be compared between depressed and non depressed subjects. | up to 1 month | 
| Skin conductance reactivity reaction time | it will be compared between depressed and non depressed subjects. | up to 1 month | 
| hedonicity score of olfactory stimuli | it will be compared between depressed and non depressed subjects. | up to 1 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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depression, emotional reactivity