linjc16/ctgov huggingface dataset:
CTHRC1: A Biomarker for Evaluation of Rheumatoid Arthritis Disease Activity

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to determine whether plasma levels of the collagen triple helix repeat containing (CTHRC1) protein can serve as a blood-based biomarker for diagnosis of rheumatoid arthritis (RA) ,and furthermore its correlation with disease activity

Detailed Description
-----------------
Rheumatoid arthritis (RA) is a chronic, progressive, autoimmune disease of synovial joints. Characterized by periods of flares with high disease activity involving both a systemic immune response and tissue-specific inflammatory events that can lead to erosive joint and bone destruction and subsequent disability . Currently, diagnosis of RA is based mainly on the extent of tenderness and swelling of the joints , levels of acute-phase reactants such as C-reactive protein (CRP) ,erythrocyte sedimentation rate(ESR) , high titers of rheumatoid factor (RF) and high titers of antibodies against cyclic citrullinated peptide (anti-CCP) in the plasma .Recently, reported increased levels of collagen triple helix repeat containing 1 protein (CTHRC1) are strongly associated with the severity of murine proteoglycan-induced arthritis and collagen antibody-induced murine arthritis (CAIA) , further CTHRC1 expression in murine experimental arthritis is increased in the synovium and specifically detected in activated murine , located at the synovial intimal lining and at the bone-pannus interface .Of interest,The expression pattern of CTHRC1 in pannus, its role in the function of FLS relevant to cartilage damage in RA, and CTHRC1's association with disease severity in murine arthritis raised the question of whether CTHRC1 could be used as a marker for RA diagnosis and monitoring of disease activity in patients .

Official Title
-----------------
CTHRC1: A Biomarker for Evaluation of Rheumatoid Arthritis Disease Activity

Conditions
-----------------
Rheumatoid Arthritis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients diagnosed as RA age more than 18 years Exclusion Criteria: other rheumatological diseases Malignancies Hepatic diseases

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Measuring of CTHRc1 , its correlation with RAdisease activity<br>Measuring of CTHRc1 levels and its correlation with RA disease activity | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CTHRC1 in RA | Measuring of CTHRc1 in Rheumatoid arthritis patients. | One year | 
| CTHRc1 and RA disease activity | Correlation of CTHRc1levels with RA disease activity | One year |
Enhancing the Outcome of Skills Training for People With Schizophrenia

Study Overview
=================
Brief Summary
-----------------
This study will determine the effectiveness of skills training in people with schizophrenia and the applicability of the acquired skills in the real world.

Detailed Description
-----------------
People with schizophrenia have a large number of social and symptom management training programs available to them. Studies suggest that these training programs are effective, but their generalizability and effectiveness in outpatient settings has not been thoroughly examined. This study will examine the treatment outcomes of a skills training approach in schizophrenic individuals taking antipsychotic medication. Participants taking stable doses of risperidone, olanzapine, or quetiapine will be randomly assigned to receive either intensive symptom management and social skills training or group therapy for 12 months. A verbal memory test will be used to stratify the randomization procedure and to control for neurocognitive functioning.

Official Title
-----------------
Skills Training for Schizophrenia: Enhancing Outcomes

Conditions
-----------------
Schizophrenia

Intervention / Treatment
-----------------
* Procedure: Social skills and symptom management training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of schizophrenia or schizoaffective disorder for > 5 years Use of stable dose risperidone, olanzapine, or quetiapine for at least 1 month with no planned medication changes Social Behavior Scale (SBS) score > 45 Willing and able to provide informed consent Exclusion Criteria: Intelligence Quotient < 70 Use of more than one antipsychotic medication Use of benzodiazepines, tricyclic antidepressants, or anticholinergic medication commonly used to treat extrapyramidal symptoms Diagnostic and Statistical Manual (DSM)-IV criteria for alcohol or other substance dependence History of any traumatic brain injury leading to loss of consciousness for > 30 minutes Diagnosis of a comorbid medical condition that could interfere with antipsychotic medication treatment or the ability to complete the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Social skills and symptom management training|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Psychotic Disorders
Evaluation of IL-6 in Synovial Fluid in Obese and Normal Weight Patients Suffering From Gonarthrosis During PTA

Study Overview
=================
Brief Summary
-----------------
Evaluate the concentration of IL-6 in the synovial fluid of obese patients suffering from gonarthrosis during knee arthroplasty surgery

Official Title
-----------------
Evaluation of Biomarker IL-6 in Synovial Fluid in Obese and Normal Weight Patients Suffering From Gonarthrosis During Knee Arthroplasty Surgery.

Conditions
-----------------
IL-6 Concentration in the Synovial Fluid of Obese Patients is 100% Higher Than the IL-6 Concentration of the Synovial Fluid in Normal Weight Patients

Intervention / Treatment
-----------------
* Diagnostic Test: Evaluation of IL-6 biomarkers in synovial fluid


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age between 55 and 85 years inclusive, Normal weight patients with BMI 18-24.9 included Obese patients with BMI ≥ 30 Patients suffering from gonarthrosis awaiting knee arthroplasty surgery Patients awaiting knee replacement surgery Patients who agree to sign informed consent Exclusion Criteria: Patients under 55 years of age. Patients over 85 years of age Patients suffering from diabetes mellitus Patients who are unable to understand Patients with severe neurological disorders or severe disability Rheumatoid arthritis patients Cancer patients Patients on immunosuppressive therapy

Ages Eligible for Study
-----------------
Minimum Age: 55 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 20 obese patients, with BMI ≥ 30<br> | Diagnostic Test: Evaluation of IL-6 biomarkers in synovial fluid<br>* Evaluation of IL-6 biomarkers in synovial fluid in obese and normal weight patients with gonarthrosis<br>|
| 20 normal weight patients with BMI between 18.5 - 24.9 inclusive<br> | Diagnostic Test: Evaluation of IL-6 biomarkers in synovial fluid<br>* Evaluation of IL-6 biomarkers in synovial fluid in obese and normal weight patients with gonarthrosis<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluate whether the IL-6 concentration in the synovial fluid of obese patients is 100% higher than the IL-6 concentration of the synovial fluid in normal weight patients |  | 1 day |
Intraoral Measurement of Pressure in Preterm Infants

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to show pressure curves in the nasopharynx in non-invasively ventilated and spontaneously breathing premature and newborn babies

Detailed Description
-----------------
The aim of the investigation is to show the pressure curves in the nasopharynx in non-invasively ventilated and spontaneously breathing premature and newborn babies, with a number large enough for an analysis. For this purpose, the pressure in the nasopharynx of these children is to be measured using a suction catheter, as is usually used to suction off mucus and saliva, and the measured values are to be evaluated with software. This method is a tried and tested method in adults for measuring the pressure conditions in the nasopharynx, which was developed and used by Mr. Olthoff. A possible later clinical application in premature and newborn infants ranges from the measurement of breathing and ventilation to manual control of respiratory support depending on the measured value to automatic triggering and control of a ventilator in the sense of nSIPPV ventilation (non-invasive synchronized intermittent positive pressure ventilation )

Official Title
-----------------
Intraoral Measurement of Pressure in Preterm Infants

Conditions
-----------------
Preterm Infants

Intervention / Treatment
-----------------
* Procedure: non-invasive ventilation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: newborns, non-invasive ventilation Exclusion Criteria: Bad clinical condition of the patient (e.g. sepsis) Bleeding tendency Anatomical peculiarities that make it difficult to insert the suction catheter through the nose (e.g. choanal atresia) Lack of acceptance of the probe by the child Proven infection / colonization of the child by a multi-resistant germ (MRGN 2-4, MRSA) or with noro- / adenoviruses Missing / withdrawn consent by the legal guardians

Ages Eligible for Study
-----------------
Minimum Age: 3 Days
Maximum Age: 3 Months

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: non-invasive ventilation|none, measurements only|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Median Pressure reached by any tape of non-invasive ventilation | The pressure reached by non-invasive ventiation (nCPAP or HFT) in neonates of any gestation is measured weekly to collect data on how to correctly set the ventilator. | 1 year |
Early Active Controlled Motion (EACM) Rehabilitation Protocol Post Open Reduction and Internal Fixation (ORIF) of Scaphoid Fractures: A Pilot Study

Study Overview
=================
Brief Summary
-----------------
There is poor research supporting the benefits of Early Active Controlled Motion (EACM) protocols post operative scaphoid fixation. Advances in surgical fixation technique for scaphoid fractures should allow for start of earlier mobilization, however there is little evidence in the literature that supports the use of these protocols within the early phases of healing. The study uses a pre-experimental design with purposeful sample population recruitment.

Official Title
-----------------
Early Active Controlled Motion (EACM) Rehabilitation Protocol Post Open Reduction and Internal Fixation (ORIF) of Scaphoid Fractures: A Pilot Study

Conditions
-----------------
Scaphoid Fixation

Intervention / Treatment
-----------------
* Other: Early Active Controlled Motion (EACM)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Date of injury and diagnosis: scaphoid fracture less than 3 weeks old Waist fractures in the middle 1/3 and distal pole 1/3 of scaphoid bone. Surgical procedure includes ORIF with screw fixation and/or percutaneous pin with screw fixation. To be included in the study the patient needs to have started rehab within the first 10 days after surgery date. Exclusion Criteria: Proximal pole scaphoid fracture Past medical history of diabetes and other peripheral vascular disorders. History of osteopenia and osteoporosis. Previously failed ORIF of scaphoid Neurovascular or nerve lesion to the involved upper extremity Cognitive deficits related to memory, attention span, judgment as documented in the EMR or need for a legal guardian to be a medical proxy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Post scaphoid fracture with screw fixation<br>Post surgical rehabilitation using an early active controlled wrist motion rehab protocol that limits the amount of proximal carpal row loading forces | Other: Early Active Controlled Motion (EACM)<br>* Early active controlled wrist motion rehab protocol using that will allow midcarpal row motion.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| functional outcome range of motion | Using a goniometer measuring the angle of wrist flexion and extension NEED TO ENTER EXPECTED ROM ranges | at entry and up to 12 months |
Sweat Sensors for Athletic Performance

Study Overview
=================
Brief Summary
-----------------
Pilot study of a soft, flexible wearable sweat sensor

Detailed Description
-----------------
Assessment of safety, and preliminary accuracy of a sweat sensor capable of operating underwater.

Official Title
-----------------
Pilot Study of a Wearable Sweat Sensor for Hydration Monitoring of Athletes

Conditions
-----------------
Healthy Adults

Intervention / Treatment
-----------------
* Device: Application of a soft patch composed of medical-grade silicone that collects sweat during a subject's natural behaviors.


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: No history of medical or surgical problems Age >18 years old Subjects willing and able to comply with requirements of the protocol Exclusion Criteria: Age <18 years old Subjects unwilling and able to comply with requirements of the protocol History of skin allergy to medical adhesive tape

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy adults<br>Healthy adults without a history of medical or surgical problems | Device: Application of a soft patch composed of medical-grade silicone that collects sweat during a subject's natural behaviors.<br>* This device contains sweat sensors embedded in an elastomer and is applied to the skin with a medical grade adhesive.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adhesion of device underwater | Percentage of devices which remain adhered during >1 hr swim trials | 2 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between local and global sweat loss | Percentage agreement of local sweat rate with body weight loss | 2 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Wearable sensor, sweat sensor
Early Saline Irrigation to Decrease Post-operative Endoscopic Debridement

Study Overview
=================
Brief Summary
-----------------
Nasal saline is a common treatment adjunct in the post-operative setting for endoscopic sinus surgery. However, the ideal timing and quantity of irrigation in the early post-operative period remains unknown. Proposed benefits of early, large volume irrigation include removal and softening of crusts, resulting in improved mucociliary clearance. The potential benefit of early large volume saline irrigation on post-operative day three to ease or reduce the need for early post-operative debridement has not been studied.

Official Title
-----------------
Early Saline Irrigation to Decrease Post-operative Endoscopic Debridement

Conditions
-----------------
Chronic Rhinosinusitis

Intervention / Treatment
-----------------
* Other: Early saline irrigation
* Other: Routine Irrigation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult patients Diagnosis of CRS with or without polyposis Undergoing bilateral endoscopic sinus surgery Availability of pre-operative CT paranasal sinuses Exclusion Criteria: Patients with diagnosis of: Primary ciliary dyskinesia Immunodeficiency Cystic fibrosis

Ages Eligible for Study
-----------------
Minimum Age: 17 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Early saline irrigation<br>Initiation of early saline irrigation | Other: Early saline irrigation<br>* Initiation of post-operative saline irrigation earlier during the post-operative course<br>|
| Active Comparator: Late or Routine Saline Irrigation<br>Routine initiation of saline irrigation | Other: Early saline irrigation<br>* Initiation of post-operative saline irrigation earlier during the post-operative course<br>Other: Routine Irrigation<br>* Routine initiation of saline irrigation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain | Pain and discomfort during early post-operative debridement on post-operative day 10 | Early post-operative (Day 10) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Endoscopic appearance | Early post-operative POSE score on post-operative day 10 | Early (post-operative day 10) | 
| Late endoscopic appearance at 6 months | Late post-operative endoscopic POSE score at 6 months | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
endoscopic sinus surgery, post-operative irrigation, pain, debridement
Topical Cannabidiol Application and Skin Vascular Reactivity

Study Overview
=================
Brief Summary
-----------------
Cannabidiol, or CBD, is an over-the-counter nutraceutical that is more commonly being used by healthy adults for pain management, recovery from strenuous exercise, and general wellness. However, little research exists on the effects of CBD in otherwise healthy individuals. This study uses iontophoresis, a common technique used in physical therapy, to determine the effectiveness of topical CBD in lessening the reflex increased cutaneous vascular conductance response to stimulation of the skin.

Official Title
-----------------
Cannabidiol and Vascular Reactivity to Skin Sensory Nerve Stimulation

Conditions
-----------------
Effect of Drug

Intervention / Treatment
-----------------
* Biological: Cannabidiol


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Men and women 18 years of age and older English speaking Non-obese class III, BMI ≤ 39.9 Normal HbA1C of <6.5% Exclusion Criteria: Abnormal resting heart rate (<60 or >100 bpm) or BP (systolic <100 or >129 mmHg, diastolic <60 or >100 mmHg) values Rash, skin disease, disorders of pigmentation Known skin allergies Diabetes Nicotine use (e.g. smoking, chewing tobacco, vaping, etc.) Illegal drug use Recent (within the last 30 days) CBD users either topical or oral Allergy or hypersensitivity to investigational agents Women who are pregnant or breastfeeding

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo<br>Vehicle control, does not contain cannabidiol | Biological: Cannabidiol<br>* Urbal Activ Extra Strength CBD Body Strong Balm applied to region of forearm to be stimulated by iontophoresis machine<br>|
| Experimental: Cannabidiol<br>Active ingredient experimental arm, contains full spectrum connabidiol | Biological: Cannabidiol<br>* Urbal Activ Extra Strength CBD Body Strong Balm applied to region of forearm to be stimulated by iontophoresis machine<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cutaneous Vascular Conductance | pulse units as measured by laser Doppler flowmetry |  5 hours |