Predictors of Post-clamping Neurologic Deficits During Carotid Endarterectomy With Regional Anesthesia

Study Overview
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Brief Summary
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Patients undergoing carotid endarterectomy may suffer from neurologic deficits (ND) during the carotid cross-clamping due to cerebral hypoperfusion. An associated risk of postoperative stroke incidence is also well established. The aim of this study is to evaluate the predictive factors associated with ND during CEA performed with RA. The perioperative implications of the ND were also evaluated.

Detailed Description
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Patients undergoing carotid endarterectomy may suffer from neurologic deficits (ND) during the carotid cross-clamping due to cerebral hypoperfusion. An associated risk of postoperative stroke incidence is also well established. The aim of this study is to evaluate the predictive factors associated with ND during CEA performed with RA. The perioperative implications of the ND were also evaluated. All consecutive patients from a tertiary referral center who underwent CEA for carotid artery stenosis (CS) and consecutive patients who presented alterations in the neurologic examination after ICA clamping during CEA are selected. The control patients, submitted to the same procedure but with no neurologic alterations, are consecutively selected.

Official Title
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Preoperative, Intraoperative and Postoperative Predictors of Post-clamping Neurologic Deficits During Carotid Endarterectomy With Regional Anesthesia

Conditions
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Carotid Endarterectomy

Intervention / Treatment
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* Procedure: carotid endarterectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: carotid endarterectomy under regional anesthesia Postclamping carotid deficit Exclusion Criteria: carotid stenting

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Neurologic deficit<br>All consecutive patients from a tertiary referral center who underwent CEA for carotid artery stenosis who presented alterations in the neurologic examination after ICA clamping during CEA area selected | Procedure: carotid endarterectomy<br>* shunt<br>|
| control<br>The control patients are submitted to the same procedure but with no neurologic alterations, are consecutively selected. a 1 to 1 ratio is used | Procedure: carotid endarterectomy<br>* shunt<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Stroke | An episode of neurological dysfunction caused by focal cerebral, spinal, or retinal infarction. | up to 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clavien-Dindo Classification >3 | Postoperative event life threatining and requiring surgical, endoscopic or radiological intervention | 30 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Carotid Stenosis, regional anesthesia