Measurement and Modification of Threat Interpretation Bias in Neurodegenerative Movement Disorders (Aims 2 & 3)

Study Overview
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Brief Summary
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The purpose of this study is conduct a pilot open trial of a web-based cognitive bias modification intervention to reduce anxiety symptoms in persons with Huntington's disease and persons with Parkinson's disease.

Detailed Description
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After being informed about the study and giving informed consent, participants will enroll in a pilot open trial of MindTrails, a web-based cognitive bias modification intervention. Participants will complete five, 20-minute MindTrails training sessions over five weeks. Additionally, assessments of anxiety, interpretation bias, and other related outcomes will be completed at baseline, week 3, week 5, and 2 months following the last training session. Participants will each complete a semi-structured interview to provide qualitative feedback about their experiences with MindTrails and anxiety.

Official Title
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Measurement and Modification of Threat Interpretation Bias in Neurodegenerative Movement Disorders (Aims 2 & 3)

Conditions
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Huntington Disease, Parkinson Disease

Intervention / Treatment
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* Behavioral: MindTrails


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis of Huntington's disease or Parkinson's disease Age 21 or older Has anxiety symptoms (NeuroQoL Anxiety short form >12) Exclusion Criteria: Unable to read and understand English Previously diagnosed with dementia Not located in the USA

Ages Eligible for Study
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Minimum Age: 21 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: Two single groups will be recruited: one including participants with Huntington's disease and the other including participants with Parkinson's disease.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: MindTrails pilot<br>This intervention involves completion of five, 20-minute MindTrails online training sessions over five weeks. | Behavioral: MindTrails<br>* MindTrails is a web-based cognitive bias modification intervention. Training sessions are designed to encourage cognitive flexibility through repeated practice assigning benign resolutions to ambiguous, anxiety-provoking situations.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of participants completing at least 50% of the MindTrails sessions | Proportion of participants completing at least 50% of the MindTrails sessions | Between baseline and week 5 | 
| Participant perceptions of perceived benefits and limitations of MindTrails | Semi-structured interviews | After completion of the intervention (week 5) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Anxiety, Interpretation bias, Cognitive bias modification