The Effect of Glaucoma Drops on of the Duration of a Pure Intraocular Gas Bubble

Study Overview
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Brief Summary
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A controlled clinical study comparing the effect of topical aqueous suppressants on intraocular gas duration.

Detailed Description
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A Prospective, Randomized Study Comparing the Effects of Topical Aqueous Suppressants on Intraocular Gas Duration following Scleral Buckling and Pneumatic Retinopexy

Official Title
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A Prospective, Randomized Study Comparing the Effects of Topical Aqueous Suppressants on Intraocular Gas Duration Following Scleral Buckling and Pneumatic Retinopexy.

Conditions
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Scleral Buckling

Intervention / Treatment
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* Drug: Timolol-dorzolamide (Glaucoma drops)
* Drug: standard post-operative topical drops


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Ability to provide written informed consent and comply with study assessments for the full duration of the study. Have undergone eye surgery including scleral buckling or pneumatic retinopexy for treatment of retinal detachment other condition at the discretion of the investigator. Exclusion Criteria: Prior surgery to treat glaucoma. Current use of glaucoma eye drops. Absence of a lens in the eye or presence of a lens implant in front of the iris (colored part of your eye). Allergy or contraindication to any of the glaucoma drops being used in this study (e.g., sulfa allergy, asthma, chronic obstructive pulmonary disease (bronchitis or emphysema), slow heart rate).

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Post surgery without glaucoma drops<br>This will be for the group that had gas duration surgery using SF6 (Sulfur Hexafluoride) or C3F8 (perfluoropropane gas tamponade) and only uses the standard post-operative topical drops. | Drug: standard post-operative topical drops<br>* Patients will receive the standard post-operative drops regardless of what group ther are in. The standard post-operative drops are Prednisolone acetate,Polymyxin B and Trimethoprim<br>* Other names: trimethoprim;|
| Experimental: Post surgery with glaucoma drops<br>This will be for the group that had gas duration surgery (using SF6 or C3F8). In addition to the standard post-operative topical drops, glaucoma drops, Timolol-dorzolamide (timolol 0.5%-dorzolamide 2%) will be given. | Drug: Timolol-dorzolamide (Glaucoma drops)<br>* Patients will receive the standard post-operative drops regardless of what group you are in. The glaucoma drops will only be given to the experimental group.<br>* Other names: timol-dorzolamide;Drug: standard post-operative topical drops<br>* Patients will receive the standard post-operative drops regardless of what group ther are in. The standard post-operative drops are Prednisolone acetate,Polymyxin B and Trimethoprim<br>* Other names: trimethoprim;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complete Resolution of Intraocular Gas Bubble | This will be reported by the patient when they see/feel the gas bubble disappear. | Following surgery, until gas bubble is gone. Up to 2 months. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants With Return of Intraocular Pressure to Normal Levels | Number of participants with a normal intraocular pressure of 10-21 mm Hg at the Month 2 visit | Month 2 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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eye, pneumatic retinopexy, topical