Comparison of Ocular Findings in Patients Between Surgical and Natural Menopause

Study Overview
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Brief Summary
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It is aimed to compare the ocular findings in patients with natural and surgical menopause.

Detailed Description
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To compare the parameters such as fundus examination, macular thickness, visual acuity and lens opacities among female patients diagnosed with menopause between the ages of 40-65.The criteria for exclusion from the study are the presence of a history of illness, drug use, smoking and alcohol use.Inclusion criteria were female patients who were in menopause and who did not use any medications. For surgical menopause, the uterus and ovaries were surgically removed at least 3 months ago.

Official Title
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Comparison of Ocular Findings in Patients Between Surgical and Natural Menopause

Conditions
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Menopause Surgical, Macula Edema, Visual Acuity Reduced Transiently

Intervention / Treatment
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* Diagnostic Test: measurement of macular thickness, corneal thickness and lens opacities


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Newly diagnosed menopause (Natural or Surgical Menopause( At least 3 months after surgery), No history of illness(Diabetes,Heart disease,Kidney disease etc.) Not Smoking Did not use alcohol Have not use any medication Age between 45-65 years BMI between 20-25 kg/m Exclusion Criteria: Smoking or Alchohol consumption Age before 45 and after 65 years Have chronic disease Using any medication Have not diagnosed Menopause BMI greater than 30 kg/m

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Natural menopause(Control group)<br>Female patients between 45-60 years of age diagnosed with menopause without any intervention | Diagnostic Test: measurement of macular thickness, corneal thickness and lens opacities<br>* The incidence of macular thickness, Corneal thickness, intraocular pressure and lens opacities will be investigated by an ophthalmologist.<br>|
| Surgical Menopause (Case group)<br>Female patients aged 45-60 years included in the study 3 months after bilateral oophorectomy and hysterectomy | Diagnostic Test: measurement of macular thickness, corneal thickness and lens opacities<br>* The incidence of macular thickness, Corneal thickness, intraocular pressure and lens opacities will be investigated by an ophthalmologist.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Macular thickness measurement | Macular thickness(micron) in both eyes will be measured by optical coherence tomography, | 3 months after menopause | 
| Detecting lens opacities | Lens opacities (Grade 1,2,3,4) will be measured by indirect biomicroscopy, | 3 months after menopause | 
| Intraocular pressure measurement | Intraocular pressures( mm Hg) will be measured and recorded with the applanation tonometry device. | 3 months after menopause | 
| Comparison of all detected data | All numerical data will be analyzed and compared with relevant statistical tests and the p value will be accepted as less than 0.05 to be considered a statistically significant difference. | 3 months after menopause | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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menopause, Eye disease, Macular changes