The Effect of Whole Body Vibration After ACLR

Study Overview
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Brief Summary
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This is a randomised clinical trial to detect the effect of an 8-week whole body vibration training on muscle function and dynamic knee function during single leg squat and single leg hop in patients after anterior cruciate ligament reconstruction

Detailed Description
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In Hong Kong, over 3000 cases of ACL reconstruction are operated annually to restore knee stability. Despite recovery of knee passive laxity and muscle strength, dynamic knee stability is often not restored. The whole body vibration has been found to improve muscle strength, proprioception and balance after ACL reconstruction. This project will investigate the effect of whole body vibration on muscle elasticity, muscle coordination and landing knee biomechanics. It may provide useful evidence to the application of whole body vibration in improving dynamic knee stability, which will lead to a significant improvement in healthcare management for ACL patients . The current study serves to provide a clinical guideline for post-ACL reconstruction rehabilitation.

Official Title
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The Effect of Whole Body Vibration on Dynamic Knee Stability in Patients After Anterior Cruciate Ligament Reconstruction

Conditions
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ACL Injury

Intervention / Treatment
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* Other: whole body vibration
* Other: Conventional exercise training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged 18-50; Physically active before injury with Tegner score more than 6 (recreational/professional sport level); Scheduled for ACLR because of sport injury; Be able to walk with a pair of elbow crutches independently at 1 month after ACLR. Exclusion Criteria: Concomitant posterior cruciate ligament or lateral collateral ligament injury in the same knee; Injury to the contralateral side; Medical problems that are contradictory to WBV; Prior experience of WBV to avoid any training or memory effect; Women with pregnancy.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: This is a randomized control trial. Participants will be randomly allocated into either intervention group(vibration training+ conventional rehabilitation program) or control group(conventional rehabilitation program).
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Vibration group<br>Participants in Vibration group will receive an 8-week whole body vibration training in addition to conventional exercise training. | Other: whole body vibration<br>* The whole body vibration is used when vibrations (mechanical oscillations) of a certain frequency are transferred to the human body. Humans are exposed to vibration through a contact surface that is in a mechanical vibrating state. It has been considered as an alternative and safe method for neuromuscular training and may be incorporated into current neuromuscular rehabilitation programs so as to enhance muscle recovery<br>Other: Conventional exercise training<br>* A set of conventional exercises designed for ACL rehabilitation<br>|
| Active Comparator: Control group<br>Participants in Vibration group will only receive conventional exercise training. | Other: Conventional exercise training<br>* A set of conventional exercises designed for ACL rehabilitation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| knee flexion angle | Peak value of knee flexion will be assessed by the skin marker-based motion analysis system (Vicon MX, Oxford, UK) during single leg squat and single leg hop landing. | immediately after intervention, three month after intervention | 
| knee valgus angle | Peak value of knee valgus will be assessed by the skin marker-based motion analysis system (Vicon MX, Oxford, UK) during single leg squat and single leg hop landing. | immediately after intervention, three month after intervention | 
| knee internal rotation angle | Peak value of knee internal rotation will be assessed by the skin marker-based motion analysis system (Vicon MX, Oxford, UK) during single leg squat and single leg hop landing. | immediately after intervention, three month after intervention | 
| Vertical ground reaction force | Peak vertical ground reaction force will be evaluated by a synchronized force plate during single leg hop landing. | immediately after intervention, three month after intervention | 
| Knee valgus torque | Peak knee valgus torque will be evaluated by a synchronized force plate during single leg hop landing. | immediately after intervention, three month after intervention | 
| Knee extension torque | Peak knee extension torque will be evaluated by a synchronized force plate during single leg hop landing. | immediately after intervention, three month after intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| muscle strength | Isometric muscle strength of quadriceps and hamstring will be tested using an hand-held dynamometer. The isokinetic muscle strength of quadriceps and hamstring will be tested at 60°/s and 180°/s by the isokinetic dynamometer | immediately after intervention, three month after intervention | 
| muscle elasticity | Shear elastic modulus of vastus medialis, vastus lateralis, semimembranosus and biceps femoris will be assessed by shear wave elastography ultrasound. | immediately after intervention, three month after intervention | 
| muscle activation | Muscle activity level of vastus lateralis, vastus medialis, biceps femoris and semitendinosus will be assessed by electromyography | immediately after intervention, three month after intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ACL, dynamic knee stability, whole body vibration