Home Bicycle Exercise and Aerobic Capacity

Study Overview
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Brief Summary
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The subjects with MetS or type 2 diabetes were enrolled for this exercise-training program. All participators underwent an indoor bicycle exercise for twelve weeks. In addition to demographic data and biochemical tests were determined after an overnight fasting. Extension of muscle strength was detected in the dominant lower extremity.

Detailed Description
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This prospective open-labeled study was conducted in Taichung Veterans General Hospital. The adult participants with metabolic syndrome and/or type 2 diabetes were enrolled. MetS. The procedures were fully explained to all subjects before the cardiopulmonary exercise test. ll enrolled subjects received a scheduled twelve-week program for exercise-training program. A commercially available bicycle with an indoor bicycle trainer are used as the home exercise training modality. All medications were not allowed to be changed during the study.

Official Title
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The Effects of Home Bicycle Exercise Program on Hyperlipidemia, Hypertension, Blood Sugar Control, Muscle Strength and Aerobic Capacity

Conditions
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Metabolic Cardiovascular Syndrome

Intervention / Treatment
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* Behavioral: bicycle exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult with metabolic syndrome or type 2 diabetes Exclusion Criteria: hyperglycemic crisis or HbA1c > 12%; serum creatinine levels greater than 200 mmol/L; acute or chronic infectious diseases; limitations in the ability to undertake regular exercise

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Bicycle Exercise<br>Bicycle Exercise for 12 weeks | Behavioral: bicycle exercise<br>* All enrolled subjects received a scheduled twelve-week exercise program. A commercially available bicycle (Giant CS800, Taichung, Taiwan) with an indoor bicycle stand (Giant Cyclotron Mag, Taichung, Taiwan) was used as the home exercise training modality.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Metabolic syndrome | Components of metabolic syndrome based on the modified Third Report of the National Cholesterol Education Program (NCEP) criteria | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle strength | A Biodex Isokinetic Dynamometer (Biodex Medical Systems, Inc., Shirley, New York, USA) was used to evaluate the muscle strength of the subjects | 12 weeks | 
| Brain-derived neurotrophic factor | Serum concentration of Brain-derived neurotrophic factor (enzyme immunoassay method, R&D Systems, Minneapolis, U.S.A.) | 12 weeks | 
| Arterial stiffness | Pulse wave velocity | 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Metabolic syndrome, Diabetes, Muscle strength, Aerobic exercise, Bicycle, Brain-derived neurotrophic factor