Clinical Characteristics of Patients With Sleep Apnea in Korea

Study Overview
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Brief Summary
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Sleep-disordered breathing including obstructive sleep apnea (OSA) is an extremely common medical disorder associated with important morbidity. The purpose of this study is to understand the clinical features and course of patients with sleep apnea in Korea. Participants who are suspected of sleep apnea due to symptoms such as snoring, witnessed apneas, waking up with a choking sensation, excessive sleepiness, non-restorative sleep, difficulty initiating or maintaining sleep, fatigue or tiredness, and morning headache will be prospectively recruited at the outpatient clinic of Seoul National University Hospital. After polysomnography (PSG) or respiratory polygraphy, patients with sleep apnea including OSA and central sleep apnea (CSA) will be followed regularly. Participants not having sleep apnea (apnea-hypopnea index < 5/hour) will only have a baseline visit. For only participants with the informed consent of donating blood, their blood samples will be collected and stored in the Seoul National University Hospital-Human Biobank (SNUH-HUB).

Official Title
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Clinical Characteristics of Patients With Sleep Apnea in Korea: a Prospective Cohort Study

Conditions
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Sleep Apnea Syndromes

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participants who are suspected of sleep apnea due to symptoms such as snoring, witnessed apneas, waking up with a choking sensation, excessive sleepiness, non-restorative sleep, difficulty initiating or maintaining sleep, fatigue or tiredness, and morning headache Exclusion Criteria: None

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| obstructive sleep apnea (OSA)<br>5 or more predominantly obstructive respiratory events [obstructive and mixed apneas, hypopneas or respiratory effort-related arousals (RERAs)] per hour of sleep during a PSG or per hour of monitoring (respiratory polygraphy) | |
| central sleep apnea (CSA)<br>PSG shows all of the following: 5 or more central apneas and/or central hypopneas per hour of sleep. The number of central and/or central hypopneas is > 50% of the total number of apneas and hypopneas. | |
| control<br>apnea-hypopnea index < 5 per hour of sleep during a PSG or per hour of monitoring (respiratory polygraphy) | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The number of participants with adherence to positive airway pressure (PAP) therapy | PAP adherence is defined as the use of PAP therapy for ≥4 h/night on ≥70% of nights | Median follow up of 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The number of deaths | The number of deaths | Median follow up of 15 years | 
| The cause of death | The cause of death | Median follow up of 15 years |