Ovarian Reserve in Diabetes Mellitus

Study Overview
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Brief Summary
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Type 1 diabetes mellitus is a common autoimmune disease. It affects women of all ages including reproductive years. Hyperglycemic condition in diabetes can cause organ damage. This study aims to measure serum hormones including FSH, LH, E2, AMH, ovarian volume and antral follicle count (indicators of ovarian reserve) in women with and without type 1 diabetes mellitus.

Detailed Description
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Type 1 diabetes mellitus is a common autoimmune disease. It affects women of all ages including reproductive years. It is showed that hyperglycemic state in diabetes results in organ damage like kidneys and eyes. Ovarian reserve is important for the reproductive period. The measurements of serum hormones including follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) and anti-mullerian hormone (AMH) will give us an idea about the ovarian reserve. The investigators aim is to measure ovarian reserve parameters in patients diagnosed with type 1 diabetes mellitus and to compare them to healthy controls. Serum FSH, LH, E2 and AMH will be measured on the 3rd day of the cycle. Antral follicle count and ovarian volume measurement will be done with ultrasonography. Ovarian reserve markers will be compared between the groups.

Official Title
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Ovarian Reserve in Patients With Type 1 Diabetes Mellitus

Conditions
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Type1 Diabetes Mellitus

Intervention / Treatment
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* Other: hormone panel and ultrasonography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Reproductive age group women: 18-40 years Women diagnosed with type 1 diabetes (case group) Women without type 1 diabetes (control group) Exclusion Criteria: Women with PCOS (polycystic ovary syndrome) history of ovarian surgery Body mass index (BMI) over 30

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| women with Type 1 diabetes mellitus<br>Reproductive age women diagnosed with type 1 diabetes mellitus | Other: hormone panel and ultrasonography<br>* Blood sampling on the 3rd day of menstrual cycle for the measurement of serum FSH, LH, E2 and AMH hormone levels and ultrasonography for antral follicle count and ovarian volume measurement will be done.<br>|
| women without Type 1 diabetes mellitus<br>Reproductive age women diagnosed with type 1 diabetes mellitus to serve as control | Other: hormone panel and ultrasonography<br>* Blood sampling on the 3rd day of menstrual cycle for the measurement of serum FSH, LH, E2 and AMH hormone levels and ultrasonography for antral follicle count and ovarian volume measurement will be done.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| E2, FSH, LH, AMH levels | E2, FSH, LH, AMH levels of blood samples will be measured | during procedure | 
| antral follicle count | antral follicles of ovaries will be counted with ultrasonography | during procedure | 
| ovarian volume | both ovaries will be measured in three dimensions with ultrasonography | during procedure |