Construction of the Evaluation System of Limb Blood Circulation After Fracture of Limbs in Children

Study Overview
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Brief Summary
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This study is aimed to construct a multi-parameter early-warning model based on usage of mannitol, using multi-factor regression and combining with previous clinical experience, literature, expert opinions. The investigators will evaluate the predictive value of the model for mannitol usage and gypsum cutting open through cohort study verification.

Detailed Description
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The investigator will retrospect the data of operative patients with limb fracture in Pediatric Orthopedics Unit of Shanghai Xinhua Hospital in 2016 to collect the basic information about this kind of patient, including age, gender, kind of fracture, temperature and color of skin, swell, artery pulse, laboratory test indicators, method of fixation, and the usage of mannitol. Then, combining the professionals' suggestions, the investigator will use multi-factor regression to identify the independent risk factors of blood circulation disorder. According to the independent risk factors, the early-warning model of blood circulation disorder will be built, and the rating scale as well. Finally, the critical value of blood circulation disorder after limb fracture will be set by receiver operating characteristic curve.

Official Title
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Construction of the Evaluation System of Limb Blood Circulation After Fracture of Limbs in Children

Conditions
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Blood Circulation Disorder

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age from 0 to 14 years; Children with limb fractures diagnosed by X-ray film; The surgical method is open reduction and wire-pin fixation or steel plate internal fixation; Children with postoperative plaster fixation; Children whose guardian signed informed written consent. Exclusion Criteria: Children with nerve damage which have caused dysfunction such as sensory and motor; Children with fracture in other parts or organic diseases.

Ages Eligible for Study
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Maximum Age: 14 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of participants with Limb Blood circulation disorder | Number of participants with circulatory disorders (using mannitol treatment) after limb fracture | Within 1 year after mannitol treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of adverse events | The adverse events include acute ischemic necrosis, osteofascial compartment syndrome and disability. | Within 1 year after mannitol treatment | 
| Blood oxygen saturation at the end of extremities | Oxygen saturation is the fraction of oxygen-saturated hemoglobin relative to total hemoglobin (unsaturated + saturated) in the blood, which can reflect the status of blood circulation. Blood oxygen saturation can be get by using percutaneous oxygen saturation monitor. | Within 1 year after mannitol treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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limb Fracture, limb blood circulation, early-warning model, Children