Shape Up! Adults Study

Study Overview
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Brief Summary
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Identify the unique associations of body shape to body composition indices in a population that represents the variance of sex, age, BMI, and ethnicity found in the US population. Describe the precision and accuracy of 3DO scans to monitor change in body composition and metabolic health interventions. Estimate the level of association of 3DO to common health indicators including metabolic risk factors (glucose, triglycerides, HDL-cholesterol, blood pressure, VAT, WC and strength) by gender, race, age, and BMI. Investigate holistic, high-resolution descriptors of 3D body shape as direct predictors of body composition and metabolic risk using statistical shape models and Latent Class Analysis.

Official Title
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Optical Body Composition and Health Assessment (Shape Up! Adults) Study

Conditions
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Healthy

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy participants will be included in the study if they have a self-reported ability to: walk one-quarter of a mile and climb 10 steps without difficulty, perform activities of daily living (ADLs) without difficulty, and have no life-threatening conditions or diseases that would alter their body composition from what is typical for their age, sex, ethnicity, and BMI. Exclusion Criteria: Participants will be excluded if they have any internal metal artifact (e.g. pacemakers, internal fixation, arthroplasty), amputation, physical impairment or previous fracture that would alter body composition assessment or are pregnant or breastfeeding. All premenopausal females will be asked for a spot urine sample for pregnancy test prior to participation. Those unwilling to comply with this will not be included.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fat mass | Measure fat mass and percent fat (arms, legs, trunk, and total) using Dual energy X-ray absorptiometry (DXA) data | 1 day | 
| Lean mass | Measure lean mass (arms, legs, trunk, and total) using Dual energy X-ray absorptiometry (DXA) data | 1 day | 
| Bone mass | Measure bone mass (arms, legs, lumbar spine, and total) and Bone Mineral Density (spine and total) | 1 day | 
| Waist to Hip ratio (WHR) from manual tape measurement | Manual physical anthropometry of waist and hip circumferences | 1 day | 
| Automatic 3D optical (3DO) scan measurement | Automated 3DO measurements generate the following: 476 girth, length, and volume measurements across the whole body. | 1 day | 
| HUMAC NORM | Will measure isokinetic strength of knee and back to assess muscle function | 1 day | 
| Jamar hydraulic hand dynamometer | Will measure grip strength to assess muscle function | 1 day | 
| Fasting glucose levels | Measure fasting glucose levels | 1 day | 
| Fasting HbA1c levels | Measure fasting HbA1c levels | 1 day | 
| Fasting insulin levels | Measure fasting insulin levels | 1 day | 
| Fasting cholesterol levels | Measure fasting cholesterol levels | 1 day | 
| Fasting triglycerides levels | Measure fasting triglycerides levels | 1 day |