Effect-site Concentration of Remifentanil for Double-lumen Tubes Intubation: Airtraq VS Macintosh Laryngoscope

Study Overview
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Brief Summary
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The 50% effective concentration of remifentanil by target controlled infusion was not determined for inhibiting the haemodynamic response during double-lumen tube (DLT) intubation. Previous study showed that Airtraq videolaryngoscope provided more stable haemodynamics than Macintosh for double-lumen tube intubation. In this study, the investigators will compare the 50% effective concentration of remifentanil between Airtraq videolaryngoscope and Macintosh laryngoscope for inhibiting haemodynamic responses during DLT intubation.

Detailed Description
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Dixon up-and-down method was used to determine 50% effective concentration of remifentanil by target controlled infusion for inhibiting the haemodynamic responses during DLT intubation with Airtraq videolaryngoscope or Macintosh laryngoscope.

Official Title
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Effect-site Concentration of Remifentanil for Inhibiting Cardiovascular Responses to Double-lumen Tube Intubation With Airtraq Videolaryngoscopy: a Comparative Study With Macintosh Laryngoscopy

Conditions
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Hemodynamic Instability, Intubation Complication

Intervention / Treatment
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* Device: Airtraq
* Device: Macintosh


Participation Criteria
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Eligibility Criteria
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Inclusion Criterias: American Society of Anesthesiologists physical status of I-II Patients aged 18-65 years BMI 18-35 kg/m2 Elective pulmonary surgery under general anesthesia to double-lumen tubes intubation Mallampati classifications Ⅰ-Ⅱ Exclusion Criterias: Emergency operation Anticipated difficult airway or history of intubation difficulties Be allergic to any of the drugs used in the experiment, or have a history of drug allergy Preoperative use of analgesic, sedative and other drugs Uncontrolled hypertension and heart disease Have a history of heavy smoking and alcohol abuse, serious drug abuse, and severe systemic infections There are severe mental and nervous system symptoms, and patients cannot cooperate with the study, such as language comprehension disorder, mental illness, etc Other clinical trials were conducted within 3 months prior to inclusion in the study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Airtraq<br>Patients received DLT intubation by Airtraq videolarygoscope | Device: Airtraq<br>* Airtraq is a kind of videolaryngoscope for intubation<br>|
| Active Comparator: Macintosh<br>Patients received DLT intubation by Macintosh laryngoscope | Device: Macintosh<br>* Macintosh is a traditional laryngoscope for intubation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Remifentanil TCI effect site concentration | preestablish remifentanil TCI effect site concentration(ng/ml) | through study completion, an average of 20 min | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mean arterial pressure | mean arterial pressure in mmHg | at entering the operation room(T1), at immediately before DLT intubation(T2), at immediately after DLT intubtion(T3), at 1 minute(T4)/2 minutes (T5)/3 minutes(T6) after DLT intubation | 
| heart rate | heart rate in bpm | at entering the operation room(T1), at immediately before DLT intubation(T2), at immediately after DLT intubtion(T3), at 1 minute(T4)/2 minutes (T5)/3 minutes(T6) after DLT intubation | 
| Narcotrend index | Narcotrend index in Arabic numerals | at entering the operation room(T1), at immediately before DLT intubation(T2), at immediately after DLT intubtion(T3), at 1 minute(T4)/2 minutes (T5)/3 minutes(T6) after DLT intubation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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double-lumen tube intubation, remifentanil, target controlled infusion