Effect of Site on Pain in Preterm Neonates

Study Overview
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Brief Summary
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Numerous experimental and clinical studies have shown that preterm neonates are particularly sensitive to stress. Preterm neonates routinely undergo painful invasive procedures. Each situation causing pain or discomfort can alter their development and cause short term cardiovascular consequences but also have long-term neurocognitive influences. Repetitive procedural pain can also lead to changes in the pain sensitivity threshold therefore. The most common painful procedures are lancing for blood glucose testing. In adults, infants and term newborns, forearm blood glucose testing has been demonstrated to be less painful than conventional sites (heel, fingers). But data is lacking in preterm neonates. The primary purpose of this study is to demonstrate a significant reduction in pain response during forearm blood lancing vs conventional sites (fingers, heel) in preterm neonates born up to 32 weeks gestation. This study is an interventional multicenter (3 centers), randomized, double bind trial with a cross over assignment. 60 premature neonates born between 23 to 32 weeks. Gestation with a postnatal age less than 72 hours that will undergo at least 3 blood glucose pricks will be included. The different sites will be randomly successively tested.

Official Title
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Impact of Alternative Blood Glucose Testing Site (Forearm) on Pain Reduction in Preterm Neonates.

Conditions
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Great Premature Newborn

Intervention / Treatment
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* Biological: Blood puncture site


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Premature neonates 23 to 32 weeks gestation Infant born with a postnatal age greater than or equal to 3 hours and less or equal to 72 hours Infant born with at least 3 blood glucose testing in less than 72 hours Exclusion Criteria: Severe congenital anomalies that could alter pain perception or expression Extremities congenital anomaly impeding blood glucose testing on different sites Infants born to mothers known to be receiving opiates Severe haemodynamic disturb Severe neurologic injury Neonate with opioids or sedatives medications No parental consent

Ages Eligible for Study
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Minimum Age: 3 Hours
Maximum Age: 72 Hours

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: The forearm as blood puncture site<br>The child receives a puncture blood on the forearm | Biological: Blood puncture site<br>* Blood puncture site<br>|
| Placebo Comparator: Fingers like blood puncture site<br>Premature receiving a puncture blood on the finger | Biological: Blood puncture site<br>* Blood puncture site<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The pain assessment | Painful response using Premature Infant Pain Profile (PIPP) | 12 months |