The Natural History of Atopic Disease in Thai Children and Association With Atopic March

Study Overview
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Brief Summary
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Atopic dermatitis(AD) is one of manifestation in atopic march. The prevalence of AD is increased. In 1998, the investigators found the prevalence of AD about 15 % in Thailand. AD is diagnosed by clinical as Hanifin and Rajka criteria. There are 3 group of severity defined by SCORAD(Scoring Atopic Dermatitis) : mild (<25), moderate (25-50) and severe (>50). The natural history of AD was mentioned in 3 groups: complete remission, persistent and intermittent. Atopic march is the progression of atopic disease that has atopic dermatitis as the first manifestation then patients will have allergic rhinitis or asthma in the future. The investigators do a retrospective study to understand the natural history of AD as well as it associate with atopic march. That might be a predictive factor of AD and atopic march

Detailed Description
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Retrospective review from out patient record. Collect the demographic data, onset of atopic march, sensitization of allergen and treatment that given to patients. For patients who have current follow up at Allergy clinic, the current symptom was collect in that visit. For patients who didn't have follow up visit, telephone interview was done. If they have symptom, investigators will ask them to come in for investigation and proper treatment. Patient was recruited in this study with parental permission. The data will collect and use statistical analysis.

Official Title
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The Natural History of Atopic Disease in Thai Children and Association With Atopic March

Conditions
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Atopic Dermatitis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis of AD by physician at birth-15 years old Diagnosed by physician by Hanifin and Rajka criteria: itching, dry skin, chronic dermatitis : at face, extensor area (infant), flexor area (children and adult), with or with out history of atopy in family Follow at allergy clinic once a year or can ask current symptom via telephone interview. Evaluate severity of the disease by SCORAD (Scoring Atopic Dermatitis ) Exclusion Criteria: Onset of atopic dermatitis more than 15 years old. Other disease: skin, cardiovascular, liver disease, endocrine, neurology, ect Not complete data collection in case record form in out patient record. Cannot be reach current symptom of patient.

Ages Eligible for Study
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Maximum Age: 15 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Atopic dermatitis<br>Atopic dermatitis is diagnosis as Hanifin and Rajka from physician. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To evaluate the natural history of atopic dermatitis in Thai children and the factors that could be associate with the progression of the disease. | complete remission (no AD rash and no topical steroid (TS) or topical tacrolimus (TT) use more than one year), persistent (use TS/TT once a month to control AD) and intermittent (other than two groups) | Recruited the AD patient who was diagnosed between at birth until 15 years old. The following time at allergy clinic about 4 years in average. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The association of atopic dermatitis and atopic march. |  | At the first diagnosis of atopic dermatitis until current Allergic visit or telephone interview.The following time at allergy clinic about 4 years in average. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Natural history, Atopic dermatitis, Atopic march