UroCCR Database: French Research Network for Kidney Cancer

Study Overview
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Brief Summary
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Within the framework for kidney cancer care, with the recent diversification of treatment modalities of these tumors and the deployment of the concept of multidisciplinary team, it was considered necessary to adapt the research tools to reality of health-care for patients with kidney cancer. UroCCR is the French research network for kidney cancer, funded by the French National Cancer Institute as part of the call for projects for clinical and biological databases (BCB). Depending on the case presentation and disease evolution, more than a thousand of different variables can be recorded. At the same time, biological samples (plasma, urine, healthy and tumor tissues) are collected. This database contains a considerable number of information and high added value since it is the result of multiple expertises that make it not only a multidisciplinary tool but also multicenter, allowing fundamental, translational and clinical research.

Detailed Description
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The UroCCR database is a national medico-scientific network focused on therapeutic management and applied research in kidney cancer. Secondary objectives: - Evaluate and compare different surgical approaches in the treatment of kidney cancer, - Evaluate and compare safety/efficacy of different drugs in the treatment of kidney cancer.

Official Title
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UroCCR Database: French Research Network for Kidney Cancer (National Multidisciplinary Clinical and Biological Database on Kidney Cancer)

Conditions
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Kidney Cancer

Intervention / Treatment
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* Procedure: Radical nephrectomy versus partial nephrectomy (according surgeon judgement)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patient with kidney cancer Patient with no opposition to collection of its data for the study Exclusion Criteria: none

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients<br>Adult patients with kidney cancer | Procedure: Radical nephrectomy versus partial nephrectomy (according surgeon judgement)<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of the rates of complications between radical nephrectomy and partial nephrectomy | Operative time, , | At Month 3, Month 6, Month12, and then every year for 5 years and every 2 years for 10 years | 
| Comparison of the rates of complications between radical nephrectomy and partial nephrectomy | Blood loss | At Month 3, Month 6, Month12, and then every year for 5 years and every 2 years for 10 years | 
| Comparison of the rates of complications between radical nephrectomy and partial nephrectomy | Clinical scores | At Month 3, Month 6, Month12, and then every year for 5 years and every 2 years for 10 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dosage of creatininemia to assess the renal function after surgery | Dosage of creatininemia | At Month 3, Month 6, Month12, and then every year for 5 years and every 2 years for 10 years | 
| Dosage of MDRD GFR to assess the renal function after surgery | Dosage of MDRD GFR | At Month 3, Month 6, Month12, and then every year for 5 years and every 2 years for 10 years | 
| Comparison of the rates of mortality between radical nephrectomy and partial nephrectomy | Medical or surgical complication rates with Clavien's grading | At Month 3, Month 6, Month12, and then every year for 5 years and every 2 years for 10 years | 
| Comparison of the rates of mortality between radical nephrectomy and partial nephrectomy | Medical or surgical complication rates with urinary fistula rate | At Month 3, Month 6, Month12, and then every year for 5 years and every 2 years for 10 years | 
| Comparison of the rates of mortality between radical nephrectomy and partial nephrectomy | Medical or surgical complication rates with necessity for nephrectomy or re-exploration | At Month 3, Month 6, Month12, and then every year for 5 years and every 2 years for 10 years | 
| Safety and efficacy of medical treatment on kidney tumor size evolution | Imaging data: tumor size evolution | At Month 3, Month 6, Month12, and then every year for 5 years and every 2 years for 10 years | 
| Safety and efficacy of medical treatment on biological parameters | Biological parameters | At Month 3, Month 6, Month12, and then every year for 5 years and every 2 years for 10 years | 
| Progression of the tumor | Imaging data: tumor location | At Month 3, Month 6, Month12, and then every year for 5 years and every 2 years for 10 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Kidney cancer, Surgical approaches, Medical treatment, Multicentric and multidisciplinary network