linjc16/ctgov huggingface dataset:
Termination of Persistent Atrial Fibrillation by Catheter Ablation

Study Overview
=================
Brief Summary
-----------------
This is a prospective, multicenter, cohort study aims to demonstrate the role of termination of AF in ablation for persistent atrial fibrillation, and evaluate the clinical outcomes in patients with or without AF termination.

Official Title
-----------------
A Prospective, Multicenter, Cohort Study of Termination of Persistent Atrial Fibrillation by Catheter Ablation

Conditions
-----------------
Atrial Fibrillation

Intervention / Treatment
-----------------
* Procedure: Catheter ablation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1. Aged 18 to 80 years old; 2. Persistent AF; 3. Nonresponse or intolerance to ≥1 antiarrhythmic drug. Exclusion Criteria: With uncontrolled congestive heart failure; Having significant valvular disease and/or prosthetic heart valve(s); With myocardial infarction or stroke within 6 months of screening; With Significant congenital heart disease; Ejection fraction was <40% measured by echocardiography; Allergic to contrast media; Contraindication to anticoagulation medications; Severe pulmonary disease e.g. restrictive pulmonary disease, chronic obstructive disease (COPD); Left atrial (LA) thrombus measured by pre-procedure transesophageal echocardiography; Having any contraindication to right or left sided heart catheterization; 11. Previous atrial fibrillation ablation; 12. Presence of an implanted cardioverter-defibrillator; 13. Any cardiac surgery within the past 2 months; 14. Poor general health; 15.Life expectancy less than 6 months.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Persistent AF Group<br> | Procedure: Catheter ablation<br>* All patients received radiofrequncy ablation.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| AF recurrence rate | AF recurrence is defined as presence of documented AF episodes of 30 recurrence is defined as presence of documented AF episodes of 30 seconds or longer duration. | 12 months |
A Study of Structure and Function of Radial Artery After Transradial Coronary Intervention

Study Overview
=================
Brief Summary
-----------------
Several approaches have been proposed to reduce the risk of RAO, including anticoagulation, immediate postprocedural sheath removal, and a small sheath/radial artery ratio. Doppler ultrasound examination showed that interrupted blood flow in RA tend to occur in the proximal end rather than distal part of the artery,which was ignored by a majority of interventional cardiologists. Different insights into occlusion location may lead to different options of sheath materials, models, catheters and puncture access. Thus, the investigators designed this present study to explore the reason of radial artery endothelial dysfuction and damage and occlusion location by ﬂow-mediated dilation (FMD) to determine the suitable method to reduce occlusion risk during TRI.

Conditions
-----------------
Intervention, Transradial

Intervention / Treatment
-----------------
* Procedure: Percutaneous coronary intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: admitted for transradial catheterization. Exclusion Criteria: femoral access, arterial circulatory disease, pathological Allen tests, decompensated heart failure, chronic renal failure

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: radial artery occlusion<br>Radial artery occlusion was the absence of a flow signal by Doppler ultrasound examination. | Procedure: Percutaneous coronary intervention<br>* Percutaneous coronary intervention was a nonsurgical technique for treating obstructive coronary artery disease<br>|
| Other: radial artery normal<br>Radial artery normal was blood flow signal by Doppler ultrasound | Procedure: Percutaneous coronary intervention<br>* Percutaneous coronary intervention was a nonsurgical technique for treating obstructive coronary artery disease<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| radial artery occlusion | radial artery occlusion was the absence of a flow signal by Doppler ultrasound examination | 6 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Transradial, ﬂow-mediated vasodilation
A Randomized, Placebo-Controlled Trial of Modafinil for Methamphetamine Dependence

Study Overview
=================
Brief Summary
-----------------
The proposed study will establish the safety and efficacy of modafinil in the treatment of methamphetamine dependence, as well as assess the affects of modafinil on cognitive function in methamphetamine users and on methamphetamine withdrawal symptoms. In this outpatient trial, methamphetamine- dependent, treatment-seeking subjects will receive modafinil or placebo daily for four weeks, along with weekly Motivational Enhancement Therapy sessions. This study will be conducted at the Addiction & Pharmacology Laboratory in San Francisco, CA, and at the New Leaf Treatment Center in Lafayette, CA, and is expected to last one year.

Official Title
-----------------
A Randomized, Placebo-Controlled Trial of Modafinil for Methamphetamine Dependence

Conditions
-----------------
Methamphetamine Dependence

Intervention / Treatment
-----------------
* Drug: Modafinil


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age between 18 and 50 years Patient is agreeable to conditions of study and signs consent form

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Modafinil<br> | Drug: Modafinil<br>* 600 mg Modafinil capsule<br>|
| Placebo Comparator: placebo (cornstarch)<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Urine Samples Negative for Methamphetamine |  | Twice weekly for 4 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Meth, Methamphetamine Addiction, Methamphetamine Treatment, Modafinil
A Clinical Trial on the Effects of Home-based Five Plus Exercise Training

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to evaluate whether walking capacity in patients with intermittent claudication is improved more by home-based 5+ exercise training than by current recommendations of daily walking. The study will elucidate if such a potential effect is dependent on changes in mitochondrial respiratory capacity, blood flow or both.

Official Title
-----------------
A Randomized Clinical Trial on the Effects of Home-based Five Plus Exercise Training

Conditions
-----------------
Intermittent Claudication

Intervention / Treatment
-----------------
* Other: Five plus exercise training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosed with intermittent claudication secondary to vascular insufficiency An ankle-brachial index between 0.4 and 0.9. Exclusion Criteria: Diagnosed with critical limb ischemia Ankle-brachial index (ABI) > 0.90 or < 0.4 Limited exercise tolerance Warfarin or heparin usage Underwent a vascular intervention in the last 6 months Active cancer, renal- or liver disease

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Usual care<br> | |
| Active Comparator: Five Plus<br>Exercise training | Other: Five plus exercise training<br>* calf raise exercise<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| absolute walking distance (meters) as measured by 6 minute walking test | treadmill 3.2 km/hour and inclination increase every 2 minute combined with 6 minute walking test | 8 weeks | 
| mitochondrial function measured by respirometry | Oxygen consumption (pmol O2 per second per mg of wet weight tissue) measured by respirometry | 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Arterial bloodflow measured by plethysmography | measured by plethysmography | 8 weeks | 
| Quality of life assessed by SF 36 and CLAU-S questionnaires | assessed by SF 36 and CLAU-S questionnaires | 8 weeks | 
| Peak oxygen uptake measured by cardio-pulmonal exercise testing | measured by cardio-pulmonal exercise testing | 8 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Mitochondria, muscle, Exercise, Blood Flow Velocity
Lipid Profile Response to Electroacupuncture Stimulation in Non Alcoholic Fatty Liver Patients

Study Overview
=================
Brief Summary
-----------------
sixty female patients suffering from non-alcoholic fatty liver disease were randomly divided into two equal groups group 1 received electroacupuncture stimulation for 6 weeks at special points of stimulation. group 2 was a control group that received nothing without any change in lifestyle and we assed the response of lipid profile post-treatment protocol in both groupes

Official Title
-----------------
Lipid Profile Response to Electroacupuncture

Conditions
-----------------
Fatty Liver , Electroacupuncture, Lipid Profile

Intervention / Treatment
-----------------
* Device: electro-acupuncture stimulation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: non alcoholic fatty liver BMI 30-40 Exclusion Criteria: Patients with: (Hepatitis C & b any form of seizure

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: two group study, one is the study group and the other is a control group
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: electroacupuncture<br>the study group received electroacupuncture stimulation at different points | Device: electro-acupuncture stimulation<br>* stimulation of acupoints of the liver meridian of lv3 lv14<br>|
| No Intervention: control group<br>a control group with no intervention | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| tri-triglycerides (mg/dl) , total cholesterol (mg/dl) , HDL (mg/dl) , LDL (mg/dl) | lowering of total lipid profile in study group | 6 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| weight (kg) , height (m), BMI (kg/m2) | calculation of body mass index | 1st week |
Mindfulness-Based Intervention in Breast Cancer Patients Undergoing Chemotherapy

Study Overview
=================
Brief Summary
-----------------
There is evidence that mindfulness-based interventions (MBIs) such as meditation, mindfulness-based stress reduction (MBSR) and yoga might improve Quality of Life (QOL) and reduce stress in breast cancer survivors. These interventions are becoming increasingly popular in cancer survivors. However, little is known about the feasibility and effect of MBIs administered during the interval of time of chemotherapy, on QOL and stress. The investigators are planning a MBI intervention study developed specifically for breast cancer survivors receiving chemotherapy (usually 4-5 months) at the investigators institution, for at least 8 sessions combined with at least 8 weeks of home-practice, in 25 women receiving chemotherapy for breast cancer.

Official Title
-----------------
Mindfulness-Based Intervention in Breast Cancer Patients Undergoing Chemotherapy

Conditions
-----------------
Breast Cancer

Intervention / Treatment
-----------------
* Behavioral: Mindfulness


Participation Criteria
=================
Eligibility Criteria
-----------------
inclusion criteria: Women 20-75 years old Diagnosed with breast cancer Scheduled to begin chemotherapy at Mayo Clinic Rochester Exclusion criteria Pregnant Practicing mindfulness

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Mindfulness Intervention<br>Mindfulness intervention | Behavioral: Mindfulness<br>* Meditation, body scan, yoga.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Feasibility - percentage of patients recruited from those approached, percentage of patients who dropped off, percentage of patients who are compliant (attending more than 75% of recommended sessions) |  | While receiving chemotherapy (usually 4-5 months) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Stress - measured by the Perceived Stress Scale - statistically and clinically significant reductions in stress | Stress will be measured before the start of chemotherapy, monthly while receiving chemotherapy (usually 4-5 months) and at 3 months after chemotherapy | 7-8 months |
Methods of Confirmation of Brain Death

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to describe the use of methods confirming brain death in the real clinical practice of the transplant program in the Czech Republic.

Detailed Description
-----------------
Organ donation is possible in the Czech Republic only after meeting the legislative requirements. These require confirmation of brain death by one of the statutory methods before organ harvesting. The use of these methods in clinical practice has not yet been described.The aim of this retrospective observational study is to describe the use of these methods in the real clinical practice of the transplant program in the Czech Republic, taking into account the legislation of other European countries.

Official Title
-----------------
Use of Different Methods of Confirmation of Brain Death in Brain Death Donors

Conditions
-----------------
Brain Death, Organ Donation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age ≥18 years organ donor Exclusion Criteria: age under 18 years

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Angiography | Cerebral panangiography | within 24 hours after the onset of signs of brain death | 
| Brainstem auditory evoked potentials | Brainstem auditory evoked potentials | within 24 hours after the onset of signs of brain death | 
| Brain scintigraphy | Brain scintigraphy | within 24 hours after the onset of signs of brain death | 
| Cerebral computed tomography angiography | Cerebral computed tomography angiography | within 24 hours after the onset of signs of brain death | 
| Transcranial Doppler ultrasonography | Transcranial Doppler ultrasonography | within 24 hours after the onset of signs of brain death |
Strawberries and Knee Osteoarthritis (OA)

Study Overview
=================
Brief Summary
-----------------
The proposed study aims to examine the hypothesis that strawberry supplementation will lower serum biomarkers of inflammation and improve knee function in patients with symptomatic osteoarthritis (OA).

Detailed Description
-----------------
The investigators propose the following two specific aims in a randomized crossover placebo-controlled trial in participants with two or more features of the metabolic syndrome and symptomatic osteoarthritis in this 12-week efficacy study: Aim 1: To assess the effects of strawberries on biomarkers of inflammation [serum levels of C-reactive protein: CRP; inflammatory cytokines: interleukin-6: IL-6; interleukin 1β: IL-1β; tumor necrosis factor-alpha: TNFα] Aim 2: To assess the effects of strawberries on knee function as assessed by overall musculoskeletal examination and pain score (ICOAP, KOOS and HAQ-DI).

Official Title
-----------------
Effects of Freeze-dried Strawberries on Systemic Markers of Inflammation and Knee Function in Participants With Osteoarthritis (OA)

Conditions
-----------------
Osteoarthritis, Knee

Intervention / Treatment
-----------------
* Dietary Supplement: FDS-Strawberry
* Dietary Supplement: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical diagnosis of knee osteoarthritis Must have waist circumference >35 inches for women and >40 inches for men Exclusion Criteria: Cancer Heart disease Smoking Berry allergy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: FDS-Strawberry<br>Freeze-dried strawberry powder (50g/d) | Dietary Supplement: FDS-Strawberry<br>* Natural frozen and dried strawberries<br>|
| Placebo Comparator: Placebo<br>Powder matched for carbohydrates and fiber in the strawberries | Dietary Supplement: Placebo<br>* Placebo powder matched for carbohydrates and fiber in the strawberries<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain Scores on the Visual Analog Scale |  | six months | 
| Inflammatory Biomarkers in Serum |  | six months |
Precise Gene Signature for Predicting Outcomes in PDAC

Study Overview
=================
Brief Summary
-----------------
The current TNM staging system is not sufficient for prediction of prognosis and cannot precisely identify the patients who are in greater need of adjuvant therapy in pancreatic ductal adenocarcinoma (PDAC). Tumor mutation and copy number variation (CNV) markers may have a higher predictive value. In this study, whole exosome sequencing was performed for patients with stage I-II PDAC undergoing R0 resection. The investigators aimed to identify genes with discrepant statuses of mutations or CNVs between patients with and without relapse within 1 year after R0 resection, and then to construct a support vector machine (SVM)-based prognostic classifier (the SVM signature) for PDAC using machine learning; the investigators then aimed to further validate the SVM signature in an independent cohort.

Official Title
-----------------
Gene Signature Developed Using Machine Learning for Precise Prediction of Relapse and Survival in Resected Stage I-II Pancreatic Ductal Adenocarcinoma

Conditions
-----------------
Stage I-II Pancreatic Ductal Adenocarcinoma (PDAC), Precise Prognostic and Predictive Signature

Intervention / Treatment
-----------------
* Procedure: Resection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Availability of hematoxylin and eosin slides with invasive tumor components Availability of clinicopathologic characteristics and follow-up data No previous history of cancer Exclusion Criteria: No formalin-fixed, paraffin-embedded (FFPE) tumor sample of primary tumor Receipt of any neoadjuvant and/or adjuvant cancer-directed therapy Survival time <3 months after resection

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| training cohort<br>30 patients undergoing resection between March 2015 and December 2016 at Chinese PLA General Hospital in Beijing, China | Procedure: Resection<br>* radical R0 resection of pancreatic adenocarcinoma<br>|
| validation cohort<br>40 patients from The Cancer Genome Atlas (TCGA) database (https://www.cancer.gov/about-nci/organization/ccg/research/structural-genomics/tcga) | Procedure: Resection<br>* radical R0 resection of pancreatic adenocarcinoma<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disease-free survival | the time to recurrence at any site or all-cause death, whichever occurred first | 3-year | 
| Overall survival | the time to death from any cause | 3-year |