Changes in Echogenicity and Muscle Stiffness in Elastography After Botulinum Toxin Injection a Spastic Muscle

Study Overview
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Brief Summary
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Muscle alterations and modifications passive biomechanical properties that occur on a spastic muscle contribute to functional disorders involved in spasticity. Botulinum toxin (TB) A is the reference treatment of the focused spasticity, and muscle source structural and biomechanical changes, very little studied in humans, especially since it is not one possibility of easily and reliably paraclinical assessment injections consequences.

Official Title
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Changes in Echogenicity and Muscle Stiffness in Elastography After Botulinum Toxin Injection a Spastic Muscle - A Monocentric Study

Conditions
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Stroke

Intervention / Treatment
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* Device: ultrasound echogenicity
* Device: elastography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: A first stroke older than nine months (acute phase and subacute stroke). Hemiplegia cerebral vascular following this stroke. Hemiplegia with an overall motor deficit plegic lower limb muscle testing level less than or equal to 3 and associating a localized spasticity lower plegic member, on the plantar flexors, assessed by the upper Ashworth Scale or equal to 1 with an injection of botulinum toxin indication of the sural triceps. written consent. Exclusion Criteria: Old stroke with motor impairment of the lower limb in the chronic stage. Concomitant muscle disease (eg myopathy, myositis ...). Patients who already received a botulinum toxin injection into the gastrocnemius muscles. Subjects with defibrillator

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: patients with hemiplegia after stroke<br>ultrasound echogenicity paraclinical assessment and elastography to patients with hemiplegia following stroke with an indication of injection of botulinum toxin into the triceps sural | Device: ultrasound echogenicity<br>* ultrasound echogenicity to patient with stroke<br>Device: elastography<br>* elastography to patient with stoke<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in muscular trophism | Change in muscular trophism treated by botulinum toxin. Muscular trophism determined by a combined endpoint assessment of muscular echogenicity following scale Heckmatt I to IV, the measurement of the thickness in mm and angle pennation fascicular of medial and lateral gastrocnemius muscles to measured with an ultrasound scanner | from baseline to 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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stroke, Botulinum toxin, Muscle alterations