Investigation on the Hesitancy of COVID-19 Vaccination Among Liver Transplant Recipients in China

Study Overview
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Brief Summary
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On WeChat platform, through a point-to-point connection, and carry on the questionnaire survey to collect information of liver transplant recipients followed-up by the department of Liver Surgery, Renji Hospital Shanghai Jiao Tong University. Patients meeting inclusion and exclusion criteria will be selected. Conduct statistical analysis to describe the incidence of adverse reactions related to COVID-19 vaccine after liver transplantation, and to compare and evaluate the factors leading to COVID-19 vaccine hesitancy.

Detailed Description
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On WeChat platform, through a point-to-point connection, and carry on the questionnaire survey to collect information of liver transplant recipients followed-up by the department of Liver Surgery, Renji Hospital Shanghai Jiao Tong University. Questionnaire items including demographic characteristics, understanding of COVID-19, attitude toward COVID-19 vaccine. Patients meeting inclusion and exclusion criteria will be selected. Conduct statistical analysis to describe the incidence of adverse reactions related to COVID-19 vaccine after liver transplantation, and to compare and evaluate the factors leading to COVID-19 vaccine hesitancy.

Official Title
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Investigation on the Hesitancy of COVID-19 Vaccination Among Liver Transplant Recipients in China

Conditions
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Vaccine Hesitancy

Intervention / Treatment
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* Other: Perceptions and attitudes towards COVID-19 and COVID-19 vaccine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age ≥ 18 recipients after liver transplantation surgery Exclusion Criteria: Incomplete data (missing questionnaire information), such as lack of age, gender, indication for transplantation, time after transplantation and other indicators loss to follow-up COVID-19 vaccination before liver transplantation

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| no hesitancy group (NHG)<br>Participants who got vaccine after transplantation or were willing to be vaccinated. | Other: Perceptions and attitudes towards COVID-19 and COVID-19 vaccine<br>* Attitude towards COVID-19; Knowledge about COVID-19 vaccine<br>|
| hesitancy group (HG)<br>Participants who were uncertain or refused to be vaccinated. | Other: Perceptions and attitudes towards COVID-19 and COVID-19 vaccine<br>* Attitude towards COVID-19; Knowledge about COVID-19 vaccine<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants with COVID-19 Vaccine Hesitancy | In the questionnaire, participants who expressed hesitancy or explicitly refused to receive the COVID-19 vaccine were considered vaccine hesitancy. | through study completion, an average of 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COVID-19, vaccine, vaccine hesitancy, liver transplant recipients, China