Photobiomodulation and Parkinson

Study Overview
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Brief Summary
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This study aimed to assess the effects of transcranial photobiomodulation in patients with Parkinson's disease (PD).

Detailed Description
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Thirty-five patients with idiopathic PD were randomly assigned to a photobiomodulation (n=17, [mean±SD] 72±7 years) or sham group (n=18, 70±8 years) during 9 weeks (2 sessions/week). The primary endpoint was the motor portion of the Movement Disorders Society-United PD Rating Scale. Secondary endpoints were the Scales for Outcomes in PD, static posturography, walking ability (ten-meter walk test [TMWT]) and functional mobility (timed up and go [TUG] test).

Official Title
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Photobiomodulation in Parkinson´s Disease: A Randomized Controlled Trial.

Conditions
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Parkinson Disease

Intervention / Treatment
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* Other: Transcranial photobiomodulation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Having been diagnosed with idiopathic PD. Stage 1-2 on the Hoehn and Yahr Scale. Having no neurological condition other than PD. Being able to stand for 2 minutes and walk 10 meters without assistance. Having no severe dyskinesias or ON-OFF phases. Exclusion Criteria: - Do not follow inclusion criteria.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Photobiomodulation group<br>17 Parkinson´s disease patients were randomly assigned to the photobiomodulation group (experimental group). Intervention: Photobiomodulation was administered using red light-emitting diodes (LEDs) with a 670-nm wavelength in six 1-minute blocks alternating the LEDs between the right and left temples, with a 30-second rest between blocks. | Other: Transcranial photobiomodulation<br>* Photobiomodulation was administered using red light-emitting diodes (LEDs) with a 670-nm wavelength (which has proven to penetrate the skull)<br>* Other names: LEDs;|
| Sham Comparator: Sham group<br>18 Parkinson´s disease patients were randomly assigned to the sham group. Intervention: Procedures for the sham group were identical as the photobiomodulation one, except that patients received photobiomodulation during only 5 seconds followed by 55 seconds with no treatment (equalling 1/12th of the energy used for the intervention group). | Other: Transcranial photobiomodulation<br>* Photobiomodulation was administered using red light-emitting diodes (LEDs) with a 670-nm wavelength (which has proven to penetrate the skull)<br>* Other names: LEDs;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The motor portion of the MDS-UPDRS. | The motor portion (part III) Movement Disorders Society-Unified PD Rating Scale. It assesses the motor signs of Parkinson´s disease (minimum and maximum score is 0 and 76 points respectively -the higher score, the higher movement disorder and vice versa-). | 9 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Motor function | The Spanish-validated version of the Short Parkinson's Evaluation Scale (SPES)/Scales for Outcomes in PD (SCOPA). It measures the Parkinson´s disease patients motor function (minimum and maximum score is 0 and 63 points respectively -the higher score, the worse motor function and vice versa-). | 9 weeks | 
| Static posturography | The centre of pressure (CoP) parameters (these CoP parameters; Length in mm, Area in mm2 and Speed in m/s are combined to report the static posturography). | 9 weeks | 
| Walking speed | Ten-meter walk test | 9 weeks | 
| TUG | Timed up and go test | 9 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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movement disorders, light therapy, motor aspects