Idiopathic Pulmonary Fibrosis (IPF) and the 3 Minutes Sit-to-stand Test

Study Overview
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Brief Summary
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This study is designed to evaluate the reproductibility and the performance of the 3 minutes sit-to-stand test in patients with idiopathic pulmonary fibrosis. To do this, the investigators are recruiting 40 patients with idiopathic pulmonary fibrosis in 2 centers (Grenoble university hospital and Lyon university hospital). Patients had to achieve an effort test on a cycle ergometer. 2 visits are planned in the hospital. During each visit, patients will perform a 3 minutes sit-to-stand test, a 1 minute sit-to-stand test and a 6 minutes walk test. During the second visit, patients will also perform a 3 minutes sit-to-stand test with measurement of oxygen uptake. The investigators will then analyse the results by comparing numbers of cycle, functional response and symptoms during the 3 minutes sit-to-stand test of the 2 visits. The investigators will also compare the functional response obtained during the 3 minutes sit-to-stand test, the 1 minute sit-to-stand test and the 6 minutes walk test. Finally, the investigators will compare the maximal values of oxygen uptake, respiration rate and expired volume obtained during the 3 minutes sit-to-stand test to the effort test on cycle ergometer.

Official Title
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Assessment of the Reproducibility of the 3 Minutes Sit-to-stand Test in Patients With Idiopathic Pulmonary Fibrosis (IPF)

Conditions
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Idiopathic Pulmonary Fibrosis

Intervention / Treatment
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* Diagnostic Test: 3 minutes sit-to-stand test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: man or woman aged less than 85 years patients with Idiopathic Pulmonary Fibrosis without any acute exacerbation during 4 months before the inclusion Non-opposition to participation in research Patient with 6 minutes walk test > 200 meters (with or without oxygen therapy) Exclusion Criteria: Patient with reduced locomotor activity, or joint pain that compromises the performance of the tests Patient with 6 minutes walk test < 200 meters Patient with an other etiology of pulmonary fibrosis Other significant pulmonary diseases Patient with unstable cardiac disease Patient who may be, according to the investigator's assessment, not cooperating or respecting the obligations inherent in participating to the study. Opposition to participation in research

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Interventional Model Description: The investigators want to test the reproductibility of a 3 minutes sit-to-stand test in patients with idiopathic pulmonary fibrosis. For this, patient perform the test during 2 visits and the investigators are going to compare the results of the two visits.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: patient with idiopathic pulmonary fibrosis<br> | Diagnostic Test: 3 minutes sit-to-stand test<br>* 3 minutes sit-to-stand test, 1 minute sit-to-stand test, 6 minutes walk test will be performed 2 times for each patients 3 minutes sit-to-stand test with oxygen uptake measurement will be performed one time for each patient<br>* Other names: 3 minutes sit-to-stand test with oxygen uptake measurement;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reproductibility of the 3 minutes sit-to-stand test in patient with idiopathic pulmonary fibrosis | Evaluate the reproductibility for the number of rise and down during the 3 minutes sit-to-stand test of the 2 visits (the investigators will compare the number of rise and sit during the 3 minutes sit-to-stand test of the 2 visits to see if they are similar) | 2 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Functional response during the 3 minutes sit-to-stand test: Oxygen saturation | Evaluate the reproductibility of functional response (oxygen saturation) during the 3 minutes sit-to-stand test | 2 days | 
| 3 minutes sit-to-stand test compared to the 6 minutes walk test: oxygen saturation | compared oxygen saturation during the 3 minutes sit-to-stand test to the 6 minutes walk test | 2 days | 
| 1 minute sit-to-stand test compared to 3 minutes sit-to-stand: oxygen saturation | Compared oxygen saturation during the 3 minutes sit-to-stand test with 1 minute sit-to-stand test | 2 days | 
| Functional response during the 3 minutes sit-to-stand test: Heart rate | Evaluate the reproductibility of functional response (heart rate) during the 3 minutes sit-to-stand test | 2 days | 
| Functional response during the 3 minutes sit-to-stand test: symptoms | Evaluate the reproductibility of functional response (symptoms) during the 3 minutes sit-to-stand test | 2 days | 
| 3 minutes sit-to-stand test compared to the 6 minutes walk test: heart rate | Compared heart rate during the 3 minutes sit-to-stand test to the 6 minutes walk test | 2 days | 
| 3 minutes sit-to-stand test compared to the 6 minutes walk test: symptoms | Compared symptoms during the 3 minutes sit-to-stand test to the 6 minutes walk test | 2 days | 
| 1 minute sit-to-stand test compared to 3 minutes sit-to-stand: heart rate | Compared heart rate during the 3 minutes sit-to-stand test with 1 minute sit-to-stand test | 2 days | 
| 1 minute sit-to-stand test compared to 3 minutes sit-to-stand: symptoms | Compared symptoms during the 3 minutes sit-to-stand test with 1 minute sit-to-stand test | 2 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Idiopathic pulmonary fibrosis, 3 minutes sit-to-stand test, Interindividual reproductibility