Prednisolone in Active Ankylosing Spondylitis (AS)

Study Overview
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Brief Summary
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to investigate whether steroids are effective in ankylosing spondylitis if steroids are effective to describe how quick they work

Detailed Description
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Treatment of inflammatory rheumatic conditions with glucocorticosteroids is a mainstay in therapy. In rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematodes and polymyalgia rheumatica glucocorticosteroids show a prompt effect in regards of musculoskeletal symptoms. Ankylosing spondylitis (AS) is an inflammatory rheumatic disease mainly affecting the spine. However peripheral joints, entheses and the eyes can also be affected. The rheumatic symptoms of AS patients typically show good and quick response to treatment with nonsteroidal antirheumatic drugs (NSAIDs). In contrast to rheumatoid arthritis there is no proof that disease modifying antirheumatic drugs (DMARDs) work. Surprisingly there is the common opinion, mainly based on personal experiences, that glucocorticosteroids in spondylarthropathies do not work. However there are no reliable clinical studies answering this question. In the literature of the last 20 years there are only single reports about the treatment of AS with highly dosed methylprednisolone (intravenous pulse therapy). The pretended lack of effectiveness of glucocorticosteroids surprises moreover as NSAIDs are very effective as well as local intraarticular steroid injections including the sacroiliac joints. In addition with magnetic resonance imaging acute inflammatory lesions can be visualized especially as subchondral edema in bone marrow. Besides about 70% of patients with active AS show elevated inflammatory serum markers such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). Moreover we could recently that a treatment of AS patients with the monoclonal antibody against TNFa (Infliximab) is highly effective. TNFa is a very important pro-inflammatory cytokine (Brandt et al 2000). For all these reasons it is very important and urgent to perform a study for the treatment of active AS with glucocorticosteroids using evaluated measuring instruments.

Official Title
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Threecenter Placebo Controlled Three Arm Trial in Patients With Active Ankylosing Spondylitis With Prednisolone

Conditions
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Ankylosing Spondylitis

Intervention / Treatment
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* Drug: prednisolone


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ankylosing spondylitis according to the modified NY criteria 1984 age between 18 and 70 years insufficient response to therapy with NSAIDs BASDAI > 4 Previous therapy with DMARDs (such as sulfasalazine, methotrexate etc.) or steroids less than or equal to 7,5mg is allowed, should be discontinued or stable 4 weeks before study start written informed consent Exclusion Criteria: Pregnancy or lactation current severe infection or during the last 3 months suspected opportunistic infection during the past 2 months (such as Herpes zoster, cytomegaly-, Pneumocystis carinii-infection), HIV-infection Malignancies severe cardial, renal, hematological, endocrinological, pulmonal, gastrointestinal (such as peptic ulcers) neurological, hepatic (viral or toxic hepatitis) concomitant disease, uncontrolled arterial hypertension remitting thrombosis, embolism Diabetes mellitus or increased blood glucose test uncontrolled glaucoma active immunization during the past 2 weeks or planned for the next 8 weeks pathologic laboratory test results: creatinine >200 µmol/l, liver enzymes > 2,5 fold, AP >2,5 fold upper normal ranges significant pathological changes during physical examination clinical trial participation during the past 30 days before screening intake of hard drugs (such as cocaine, heroin) therapy with more than 7,5 mg prednisolone, intraarticular steroids during the past 4 weeks before study start current application for retirement

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: prednisolone|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 50% improvement of BASDAI after 14 days of treatment |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improvement of pain on a VAS 0 - 10 |  |  | 
| Decrease of CRP/ BSG |  |  | 
| Number of swollen/tender joints |  |  | 
| number of enthesitic localisations |  |  | 
| improvement of function (BASFI) |  |  | 
| improvement of quality of life (SF12) |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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treatment, ankylosing spondylitis, prednisolone, trial, steroid