Adductor Canal Block and Effect of 10 Versus 30 ml Ropivacaine on Muscle Strength: a Randomized Study in Healthy Volunteers

Study Overview
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Brief Summary
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To investigate whether reducing the volume (30 versus 10 ml) ropivacaine injected can reduce the number of subjects with impaired muscle strength following adductor canal block. We hypothesized that adductor canal block with 10 ml 0.1% ropivacaine preserves quadriceps strength compared with an adductor canal block with 30 ml.

Official Title
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Adductor Canal Block and Effect of 10 Versus 30 ml Ropivacaine on Muscle Strength: a Randomized Study in Healthy Volunteers

Conditions
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Muscle Strength, Healthy Volunteers

Intervention / Treatment
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* Procedure: Adductor canal block with ropivacaine 0.1%


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18-30 years Men ASA 1 Body Mass Index 18-25 Exclusion Criteria: Allergy to study medication Earlier trauma or surgery to the lower limb Diabetes Mellitus

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 30 ml<br>30 ml ropivacaine 0.1%, single bolus | Procedure: Adductor canal block with ropivacaine 0.1%<br>* US-guided adductor canal block<br>|
| Experimental: 10 ml<br>10 ml 0.1% ropivacaine, single bolus | Procedure: Adductor canal block with ropivacaine 0.1%<br>* US-guided adductor canal block<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of subjects with reduced quadriceps strength | The difference between the two volumes in number of subjects experiencing a reduction in quadriceps muscle strength by more than 25% from baseline in two consecutive assessments. | 0.5 to 6 hours post block | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quadriceps strength in percentage of baseline | The difference between the two volumes in maximum voluntary isometric contraction (MVIC) of the quadriceps muscle, assessed as percentage of the baseline value. | 2, 3 and 4 hours post block | 
| Quadriceps strength calculated as AUC | The difference between the two volumes in maximum voluntary isometric contraction (MVIC) of the quadriceps muscle calculated as area under the curve (AUC) | 30 minutes to 6 hours post block | 
| Modified 30-second Chair Stand test | The difference between the pre block value and the post block value in the modified 30-second Chair Stand test performed on one leg, between the two volumes. | 2 and 4 hours post block | 
| VAS pain scores during warmth stimulation | The difference between the two volumes in VAS pain score during warmth stimulation. | Mean value for the periode 30 minutes - 6 hours post block | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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adductor canal block, healthy volunteers, US-guided peripheral nerve block, lower limb