linjc16/ctgov huggingface dataset:
Short-term Outcome of Covid-19 Surgical Patients: Case-series of a High-risk Area Community Hospital

Study Overview
=================
Brief Summary
-----------------
The investigators retrospectively evaluated all the patients operated in a high-risk community hospital from the first Italian case of Covid-19 (February 21st) to the April 10th (in order to have at least a 30-days follow-up). The investigators selected those patients who had a preoperative or post-operative positive Real Time - Polymerase Chain Reaction (RT-PCR) for SARS-CoV-2 and the clinical outcome of the participants was evaluated in term of need of Intensive Care Unit (ICU) post-operative recovery, medical and surgical complications, length of hospital stay and death.

Official Title
-----------------
Short-term Outcome of Covid-19 Surgical Patients: Case-series of a High-risk Area Community Hospital

Conditions
-----------------
General Surgery, Disease Outbreaks

Intervention / Treatment
-----------------
* Procedure: Surgical procedures performed under general anesthesia


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: preoperative or post-operative positive Real Time - Polymerase Chain Reaction (RT-PCR) for SARS-CoV-2 surgical procedure in elective or acute care surgery performed under general anesthesia Exclusion Criteria: patients operated without general anesthesia patients preoperatively intubated for Covid-19
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Covid-19 patients operated (February 21st -April 10th)<br> | Procedure: Surgical procedures performed under general anesthesia<br>* Surgical procedures performed under general anesthesia in patients with perioperative SARS-CoV-2 infection<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality |  | 30 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Surgery, Covid-19, SARS-CoV-2, Surgical outcome
Italian Survey on Paediatric and Neonatal MRI

Study Overview
=================
Brief Summary
-----------------
Paediatric anaesthesia care in the Magnetic Resonance Imaging is a challenge for clinicians. The recent debate about the role of anaesthetic agent on neural development, encouraged an evaluation of their actual activity in this environment. In this active call survey, the authors sought to delineate the Italian situation regarding national centers, staff involved, monitoring and tools available. The primary aim was to evaluate clinical practice in childhood management in Magnetic Resonance suite. This study was designed as prospective phone survey on the setting of a complete sample of all national centers performing almost a paediatric discharge in the 2014, obtained from Italian Health Ministery registers. The three section survey was fill out with the Physician in charge in Magnetic Resonance suite. The Main outcome was a descriptive and exploratory analyses about the organization setting of the Centers (procedures, performers, monitoring and tools).

Official Title
-----------------
Children and Neonates Anaesthesia in Magnetic Resonance Environment in Italy. An Active Call Survey

Conditions
-----------------
Premature Birth, Cerebral Disorders Congenital

Intervention / Treatment
-----------------
* Other: questionnaire


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Uncooperative children < 14 years old premature babies Exclusion Criteria: . collaborating children

Ages Eligible for Study
-----------------
Maximum Age: 14 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: questionnaire|questionnaire|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Descriptive practice for children and neonates management in MRI |  | 3 monthes |
Comparison of Laparoscopic Procedures With and Without the Aid of the AutoLap System- a Robotic Camera Holder

Study Overview
=================
Brief Summary
-----------------
The objective of this study is to evaluate the ability to reduce the number of OR personnel required while performing the following procedures: colon resections, cholecystectomies and anti-reflux/hiatal hernia surgery with the AutoLap system compared with the standard operation.

Official Title
-----------------
Comparison of Laparoscopic Procedures With and Without the Aid of the AutoLap System- a Robotic Camera Holder

Conditions
-----------------
General Laparoscopic Surgeries

Intervention / Treatment
-----------------
* Device: AutoLap system


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Aged ≥ 18 years Able to provide a written informed consent Exclusion Criteria: Pregnancy Obesity (BMI >35 Kg/m2) Contra-indications for performing laparoscopy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control Group<br>Patients in this group will undergo an elective standard laparoscopic procedure with a designated OR staff to maneuver the laparoscopic camera. The procedures will be performed according to the hospital and OR routine procedure. | |
| Experimental: AutoLap Group<br>Patients in this group will undergo a laparoscopic procedure using the AutoLap system. In this group the surgeon will use the AutoLap system to hold and control the movements of the laparoscopic camera. | Device: AutoLap system<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Success rate in performing an operation with at least one OR person less |  | During surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of the operation |  | During surgery | 
| Number of times the laparoscope is removed for cleaning |  | During surgery | 
| Usability evaluation |  | Up to two days post surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Laparoscope holder, Colon resection, Right hemicolectomy, Left hemicolectomy, Sigmoid resection, Anti-reflux, Hiatal hernia
Autosomal Dominant Polycystic Kidney Disease Somatic Mutation Biorepository

Study Overview
=================
Brief Summary
-----------------
This study will analyze the germline and somatic mutations underlying the development of ADPKD in order to better understand the genetic mechanism responsible for the cystic transformation. Once identified, these mutations could help us understand better the mechanism leading to the development of this disease and may explain at least in part the phenotypic variability.

Detailed Description
-----------------
The presentation of ADPKD renal and extrarenal manifestations varies widely, even within families, and has been attributed to numerous genetic factors. One principal explanation came with the discovery that renal cyst lining cells from ADPKD patients undergo secondary somatic mutations, selective loss of the second copy of a respective normal polycystic kidney disease (PKD) gene. These somatic mutations can occur in either polycystic kidney disease 1 (PKD1) or polycystic kidney disease 2 (PKD2). Furthermore, various cysts in the same patient have been reported to harbor different somatic mutations. These findings implicated a cellular recessive mechanism for cyst formation in ADPKD, suggesting the possibility that the observed intra-familial variation in disease phenotype may, at least in part, be explained by variation in mutation type, the timing and number of somatic second-hit mutations in individual family members affected with the disease. However, there is currently very little known about the cellular genetic mechanism leading to cysts development and very few studies, addressing this issue.

Official Title
-----------------
Autosomal Dominant Polycystic Kidney Disease Somatic Mutation Biorepository

Conditions
-----------------
Autosomal Dominant Polycystic Kidney Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Males or females 18 years of age or older Confirmed diagnosis of ADPKD Undergoing a native nephrectomy Willing and able to provide informed consent Exclusion Criteria: Unable or unwilling to provide informed consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The presence of somatic PKD 1/2 gene mutations in cyst epithelial cells | The presence of mutations will be measured by next generation sequencing (NGS) and other tools for mutation analysis. | 10 YEARS |
T-mult: Exploring the Impact of TMS Induced Virtual Lesions on the Multimodal Brain Network and Cognition

Study Overview
=================
Brief Summary
-----------------
T-mult is an experimental study using low-frequency (1Hz) single-sesson rTMS to the DLPFC (versus sham rTMS) to explore the effect of virtual lesions on the brain network and cognition in 100 healthy adults (20-65 years old).

Official Title
-----------------
T-mult: Exploring the Impact of TMS Induced Virtual Lesions on the Multimodal Brain Network and Cognition

Conditions
-----------------
Healthy Cognition

Intervention / Treatment
-----------------
* Device: repetitive transcranial magnetic stimulation (rTMS)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age between 20 and 65 years old Native Dutch speaker Able to provide written informed consent Exclusion Criteria: History of diagnosed neurological or psychiatric disease (including traumatic head injury) Current and regular use of centrally acting drugs (recreational or prescribed, including analgesics), including the use of alcohol  8 hours prior to an appointment Presence of any contraindications for MRI, MEG, or TMS (including resting motor threshold >75% of maximum stimulator output or no useful motor-evoked potential elicitable) Previous rTMS treatment

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: real rTMS<br>verum rTMS to the DLPFC, 1500 1Hz pulses at 120% RMT, 25 minutes total | Device: repetitive transcranial magnetic stimulation (rTMS)<br>* real versus sham rTMS<br>|
| Sham Comparator: sham rTMS<br>sham rTMS to the DLPFC, 1500 1Hz pulses at 120% RMT, 25 minutes total | Device: repetitive transcranial magnetic stimulation (rTMS)<br>* real versus sham rTMS<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognitive change | Change in performance on a neuropsychological test measuring cognitive functioning in the domain of executive functioning | baseline versus directly post-intervention (max. 8 weeks after baseline) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Brain network change | Change in brain network organization as characterised by multimodal neuroimaging | baseline versus directly post-intervention (max. 8 weeks after baseline) |
Achieving Blood Pressure Control Through Enhanced Discharge

Study Overview
=================
Brief Summary
-----------------
The primary aim of the study is to determine if enhanced discharge from the emergency department will improve blood pressure control and self-care management. Enhanced discharge will include a hypertension intervention delivered by a touch-screen kiosk over a three month period.

Detailed Description
-----------------
A targeted sample of patients with uncontrolled blood pressure at the time of their emergency department visit discharge will be randomized into either standard or enhanced discharge. To control for medication effects in achieving blood pressure control, both groups will receive similar blood pressure medication while actively participating in the study.

Official Title
-----------------
Achieving Blood Pressure Control Through Enhanced Discharge

Conditions
-----------------
Hypertension

Intervention / Treatment
-----------------
* Behavioral: Patient education


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Present with uncontrolled blood pressure to the emergency department (>140/90 for non-diabetics and >130/80 for diabetics) Self-reported history of hypertension Exclusion Criteria: End-stage renal disease No history of hypertension Do not present with uncontrolled blood pressure

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 89 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Enhanced discharge<br>Patient education about hypertension delivered through a touch-screen kiosk at 4 time points in addition to standard discharge. | Behavioral: Patient education<br>* Patient education on hypertension delivered through a touchscreen kiosk.<br>|
| No Intervention: Standard discharge<br>Standard discharge is patient instruction, instructions for follow-up to primary care and medication/prescription | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood Pressure (Systolic) at 180 Days | Systolic Blood Pressure (SDB) at 180 days post-discharge | 180 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient Activation Measure (PAM) | Measure of how actively involved patient is in their medical care. | Baseline | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Patient education, Hypertension, Patient activation
The Impact of Integration of Ultrasound on CPR Quality - A Video Review Study

Study Overview
=================
Brief Summary
-----------------
High-quality cardiopulmonary resuscitation (CPR) is essential for return of spontaneous circulation (ROSC) in patients with cardiac arrest. However, some factors are known to be related with delays in chest compressions such as bed transfer, setting of CPR device, pulse and rhythm checks. This study aims to evaluate the potential impact of ultrasound on CPR quality by using retrospective video analysis. All CPR scenarios in our department were recorded and masked for the purpose of video analysis. The investigators will record in-scene resuscitation manpower, the factors to interrupt chest compressions and whether introducing ultrasound into resuscitation process is related with delays in chest compressions. In addition, the investigators collect the patient's sex, age, initial rhythm and prognosis, including ROSC, survival to admission and survival to discharge.

Official Title
-----------------
The Impact of Integration of Ultrasound on CPR Quality - A Video Review

Conditions
-----------------
Cardiopulmonary Resuscitation

Intervention / Treatment
-----------------
* Behavioral: ultrasound use during resuscitation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: adult patients (more than 20 years) non-traumatic cardiac arrest Exclusion Criteria: traumatic cardiac arrest age less than 20 years.

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| ultrasound use during resuscitation<br>The group with ultrasound integrated into the resuscitation efforts. | Behavioral: ultrasound use during resuscitation<br>* ultrasound use during resuscitation<br>|
| no ultrasound use during resuscitation<br>The group without ultrasound integrated into the resuscitation efforts. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ultrasound use would not delay in chest compressions during resuscitation. | chest compression fraction (chest compression time/total resuscitation time) between two groups. | 60 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ultrasound use would not influence the rates of return of spontaneous circulation. | rates of return of spontaneous circulation. | 60 mintues | 
| Ultrasound use would not influence the rates of survival to admission. | rates of survival to admision between two groups. | 7 days. | 
| Ultrasound use would not influence the rates of survival to discharge. | rates of survival to discharge between two groups. | 3 months. |
A Clinical Study of Online Active Play Program With Adolescents

Study Overview
=================
Brief Summary
-----------------
To assess the efficacy of an online, active play program (Revival Active Program) in reducing the symptoms of anxiety and depression in community-based adolescents,, a retrospective community based participatory research was conducted with 32 adolescents aged between 11-17 years old. Program was conducted during Covid-19 lockdown from March 2020 to June 2020 to support children and families in isolation.

Official Title
-----------------
A Clinical Study of Online Active Play Program With Adolescents During COVID-19 Lockdown

Conditions
-----------------
Anxiety, Depression

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children at the online program for whole duration indicating a symptom level of, at minimum, above mean on anxiety and/or depression on self-report measures Parental consent before stating the program Exclusion Criteria: Children at normal levels of mental health screening Children who did not complete the intervention period

Ages Eligible for Study
-----------------
Minimum Age: 11 Years
Maximum Age: 17 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anxiety | Screen for Child Anxiety Related Disorders (SCARED) child version was used to assess anxiety levels. | Change from baseline anxiety at 6 weeks | 
| Depression | Severity Measure for Depression child version was used to measure depression levels | Change from baseline depression at 6 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Adolescents, Online Active Revival Program
Predictive Factors of the Treatment Failure in Hepatitis C Virus (HCV) Infected Patients Treated With Telaprevir

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to 1- detect and quantify HCV-PI resistant mutants with ultra-deep pyrosequencing (UDPS) technology, 2 - detect SNPs in P-glyocoprotein and CYP3A genes, in HCV mono-infected patients under/after Telaprevir treatment.

Official Title
-----------------
Predictive Factors of the Treatment Failure in HCV Mono-infected Patients Treated With Pegylated-interferon/Ribavirin/Telaprevir.

Conditions
-----------------
Chronic Hepatitis C

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: HCV mono-infected subjects Age > 18 years Exclusion Criteria: HBV co-infection

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| virological resitance |  | 12 weeks after treatment | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hepatitis C, Direct Antiviral agent (DAA), Ultra-deep pyrosequencing, Single polynucleotide polymorphisms, Treatment-resistant mutants, Hepatitis C Virus Protease Inhibitor