linjc16/ctgov huggingface dataset:
Organophosphate Pesticides and Human Reproductive Health

Study Overview
=================
Brief Summary
-----------------
This prospective cohort study assesses the effects of exposure to organophosphate (OP) pesticides on adverse reproductive outcomes in both male and female agricultural workers in China. We will enroll women and their spouses, who are attempting to become pregnant, and observe reproductive endpoints including (1) semen parameters (concentration, total count, motility, progression and morphology), (2) menstrual disorders (oligomenorrhea, amenorrhea, polymenorrhea, intermenstrual bleeding, prolonged menstrual bleeding, dysmenorrhea, and irregular menstruation); (3) alterations in hormone patterns including reduced estrogen excretion (REE), anovulation, abnormal luteal phase (ALP), and abnormal follicular phase (AFP) in women and abnormalities of LH, FSH, TSH, SHBG, inhibin-B and testosterone in men; (4) fecundability; and (5) pregnancy outcomes including spontaneous abortion, preterm delivery, low birth weight, and intrauterine growth retardation.

Conditions
-----------------
Fecundability, Spermatazoa Disorders, Menstruation Disorders, Endocrine Dysfunction

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: it must be the first marriage for both the woman and her husband and they must currently live in the study area; the female's age must range from 20 to 34 years; the couple has no plan to leave the study area in which they live for the next two years. Exclusion Criteria: those who are currently pregnant; those who have tried unsuccessfully to get pregnant for at least 1 year; those who are current or former smokers; those who plan to move in the coming year.

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 34 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Using Neuroscience to Optimize Digital Health Interventions Across Adulthood

Study Overview
=================
Brief Summary
-----------------
The goal of this study is to investigate the extent to which brain imaging data predict health behavior change, compared to participant self-reports.

Official Title
-----------------
Using Neuroscience to Optimize Digital Health Interventions Across Adulthood

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Other: Motivational Messages


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy adults ages 30-80 who read/understand English, 50% male and 50% female, and a maximum of 50% will be white. Exclusion Criteria: Pregnancy History of head injury Mental illness diagnosis Psychoactive medication Psychiatric or neurological history Claustrophobia Ferrous metal implanted within the body (those with fMRI-compatible implanted devices will not be excluded, but the eligibility of their devices will be first verified.) Asthma, injuries, or other health conditions which inhibit daily physical activity Subjects must not already meet the recommended amount of physical activity of moderate-intensity physical activity for 150 minutes a week or 75 minutes at vigorous-intensity a week. Duke students are excluded from this study

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Adult Participants<br>Messages regarding physical activity will be texted to participants. | Other: Motivational Messages<br>* Messages regarding physical activity will be texted to participants.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Physical Activity as measures by FitBit |  | Baseline (14 days after the 1st visit), End of study (80 days after the MR visit) |
Evaluation of the Value of Cerebral Perfusion Scintigraphy in the Study of Post-stroke Fatigability

Study Overview
=================
Brief Summary
-----------------
At present there is no consensus for post-stroke imaging except for the realization of early cerebral CT at 24 hours post-thrombolysis. The use of cerebral perfusion scintigraphy would predict the course of a stroke. Indeed, it has been shown that a good perfusion is linked to a good evolution of the neurological deficit. This test is used routinely to evaluate cerebral perfusion in patients with stroke. This technique was also used to study the mechanisms of post-stroke aphasia and to highlight neuronal disconnections after stroke, a reflection of the functioning of neural networks. Neuropsychological tests are almost always done at 3 months. Fatigue is studied: PSF scale at 3 months, 6 months and 2 years. Research needs to be continued in this area because the pathophysiology remains unknown and the symptoms are disabling for patients. Using cerebral perfusion imaging would bring elements of understanding of this mechanism and ultimately improve the management of patients.

Official Title
-----------------
Evaluation of the Value of Cerebral Perfusion Scintigraphy in the Study of Post-stroke Fatigability

Conditions
-----------------
Fatigability Post Stroke

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients: 18 to 60 years old at the initial diagnosis Admission for transient ischemic attack, stroke, dissection, TVC RANKIN less than or equal to 2 Neuropsychological tests at +3 months: MoCA> 26 (to eliminate cognitive deteriorations too important for the good realization of the battery) Absence of psychiatric history Absence of psychotropic medication No history of stroke No complaint of pre-stroke fatigue Having signed the consent form Exclusion Criteria: Impossibility of giving the subject or his family enlightened information (subject in emergency situation, difficulties in understanding the subject, etc.) Subject under the protection of justice Subject under guardianship or curatorship Refusal of the patient to participate in the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluate fatigue symptoms in stroke patients |  | After the period following a stroke: 1 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
fatigability post stroke, post stroke, high-speed CT, MRI
GSK372475 Bioequivalence Study

Study Overview
=================
Brief Summary
-----------------
The study is to show the new salt formulation of GSK372475 is equivalent to the old salt formulation of GSK372475.

Official Title
-----------------
An Open Label, Randomized, Parallel Groups, Bioequivalence Study to Compare a Single Oral Dose of GSK372475B or GSK372475C in Male and Female Healthy Volunteers.

Conditions
-----------------
Healthy Subjects, Depressive Disorder

Intervention / Treatment
-----------------
* Drug: GSK372475


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy Males/Females aged 18-45 years Non-smokers BMI 19-30 kg.m2 QTc<450msec Exclusion Criteria: Use of oral contraception Positive breath alcohol and drug screen Regular alcohol consumption Current psychiatric illness or within 1 year. History of GI, hepatic or renal disease Uncontrolled hypertension

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: GSK372475|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| GSK372475 plasma level at AUC0-72, AUC0-inf, CMax and TMax |  | at predose, 0.5,1-24, 36,48,60,72,96 and 1-4 weeks post dose. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adverse events |  | all visits | 
| vitals (all visits) + ECG |  | at screening,Day-1, predose, 1,6,24,48,72 and week 2 post dose. | 
| labs |  | at screening and 2 weeks post dose | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Healthy Bioequivalence
A Study on Safety and Efficacy of Propofol in Small Children Under 2 Years of Age

Study Overview
=================
Brief Summary
-----------------
This retrospective study the safety and efficacy of intravenous propofol used in children under 2 years of age during general anesthesia for surgery.

Detailed Description
-----------------
EMR review of intravenous propofol used in target controlled infusion method in children under 2 years old.

Official Title
-----------------
A Retrospective Study on Safety and Efficacy of Propofol in Small Children

Conditions
-----------------
Heart Rate Low, Anesthesia; Functional

Intervention / Treatment
-----------------
* Drug: Propofol


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children under 2 years of age Children who received intravenous propofol for maintenance of anesthesia Exclusion Criteria: Children who underwent general anesthesia with inhalational anesthetics

Ages Eligible for Study
-----------------
Maximum Age: 2 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| children < 2 years old<br>Children under 2 years of age who received intravenous propofol during general anesthesia. | Drug: Propofol<br>* Intravenous administration with dose of 100-200mcg/kg/min<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Safety: blood pressure | blood pressure | Intraoperative 1 day | 
| Safety: blood pressure | blood pressure | Intraoperative 7th days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bispectral index | optimal surgical condition | Intraoperative |
Carotid Plaque Length to Predict Cardiovascular Events

Study Overview
=================
Brief Summary
-----------------
This multicenter study involved 5 hospitals (Changhai Hospital; Yueyang Hospital of Shanghai University of Traditional Chinese Medicine; Gongli Hospital; Putuo Hospital of Shanghai University of Traditional Chinese Medicine; No. 904 Hospital of the PLA Joint Logistics Support Force Wuxi). The study enrolled 5000 patients for suspected CAD who referred to coronary angiography from January 2017 through December 2018.

Detailed Description
-----------------
Patients with coronary artery disease who were confirmed by coronary angiography were eligible for the study. Carotid ultrasonography was performed before coronary angiography, and carotid intima-media thickness (IMT), maximum thickness and length of all plaques were measured.

Official Title
-----------------
Carotid Plaque Length to Predict Cardiovascular Events

Conditions
-----------------
Coronary Artery Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients≥18 years old, those who underwent carotid ultrasonography and first coronary angiography simultaneously. Exclusion Criteria: Patients with known coronary artery disease, previous coronary or carotid revascularization, missing carotid ultrasound or coronary angiography results.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Carotid plaque length<br>Patients underwent carotid ultrasonography and first coronary angiography simultaneously | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| major cardiovascular event | A composite of cardiovascular death, myocardial infarction, and ischemic stroke | 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| major vascular event | A composite of cardiovascular death, myocardial infarction, ischemic stroke, and coronary artery revascularization | 3 years | 
| all-cause death |  | 3 years | 
| cardiovascular death |  | 3 years | 
| myocardial infarction |  | 3 years | 
| ischemic stroke |  | 3 years | 
| coronary artery revascularization | coronary artery bypass grafting or percutaneous coronary intervention | 3 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Carotid Artery Ultrasound, Carotid Plaque, Coronary Artery Disease
Stress Hyperglycemia. Potential Role of Incretin Analogs

Study Overview
=================
Brief Summary
-----------------
This is a prospective observational study to examine the levels of glucoregulatory hormones, with special focus on incretins levels, in critically ill patients with stress hyperglycemia.

Official Title
-----------------
Stress Hyperglycemia in Critically Ill Patients. Potential Role of Incretin Analogs. A Preliminary Study

Conditions
-----------------
Hyperglycemia, Critical Illness

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age > 18 years Emergent ICU admission Written informed consent from patient or relative. Exclusion Criteria: Previously known type I or type II diabetes. Patients who received insulin or oral antidiabetic agents before ICU admission. Malignancies. Scheduled surgery Patients receiving enteral or parenteral nutrition. Inability to obtain informed consent.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incretins plasmatic levels | 28 days and ICU mortality | 28 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| glucagon | 28 days and ICU mortality | 28 days | 
| insulin | 28 days and ICU mortality | 28 days | 
| cortisol | 28 days and ICU mortality | 28 days | 
| HOMA index | 28 days and ICU mortality | 28 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Stress hyperglycemia, Incretins, GLP-1, GIP, glucoregulatory hormones
Use of Robotics for Cholecystectomy; Retrospective Review of Outcomes, Set Up and Learning Curves

Study Overview
=================
Brief Summary
-----------------
Comparing the use of surgical robotics during a Cholecystectomy, comparing different platforms and approaches (multi port verses single port).

Detailed Description
-----------------
This study is a restrospective review of charts, including operating room notes as well as operating room documentation of procedures. Currently there are numerous methods considered to be the Standard of Care in the surgical treatment of Cholecystitis, or Cholelithiasis, including Open Surgery, Laparoscopic, and Robotic Assisted Laparoscopic Surgery. This study retrospectively reviews the intraoperative and post operative clinical outcomes of Laparoscopic and Robotic Assisted Surgery at U.C. Davis Medical Center to: 1) establish the role of robotics in laparoscopic surgery, and 2) to assess the learning curve by surgeons.

Official Title
-----------------
Evolution of Robotic Cholecystectomy; the U.C. Davis Experience.

Conditions
-----------------
Cholecystitis, Cholelithiasis

Intervention / Treatment
-----------------
* Procedure: Cholecystectomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients that have undergone robotic assisted laparoscopic cholecystectomy Exclusion Criteria: Patients under the age of 18, or not choosing to have surgery.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cholecystitis<br>Patients consented for robotic assisted cholecystectomy evaluated in study. | Procedure: Cholecystectomy<br>* Single Port and Multi-Port approaches trans-laparoscopic approaches with or without the use of the daVinci Surgical Robotic System.<br>* Other names: daVinci Surgical Robotic System;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparing hernia rates between multi-port verses single port approaches. | Comparing multi port and single port approaches. Patients will be followed up under the standard of care model, normal clinical follow-ups required post surgery (10 Days to 2 weeks post operative) with additional clinical visits as required to monitor post operative complications (if any). | June 2004 through May 2015 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cholecystitis, Cholelithiasis
Motivation Effects During Cued Visual Search

Study Overview
=================
Brief Summary
-----------------
In this line of research, we are examining whether motivation increases the utilization of target (positive) or distractor (negative) color cues to improve visual attention performance.

Detailed Description
-----------------
When finding a search target, receiving a target cue or distractor cue can increase search efficiency. We are examining whether we can improve people's use of the cues to aid visual search performance if we increase their motivation through reward or time pressure.

Official Title
-----------------
Motivation Effects During Cued Visual Search

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Behavioral: Motivation Manipulation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: normal or corrected to normal visual acuity, normal color vision Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Interventional Model Description: All participants receive each level of visual cue type and motivation.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Within-subjects motivation manipulation<br>Low or high motivation | Behavioral: Motivation Manipulation<br>* On some trials, participants have lower motivation and on other trials participants have higher motivation.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Button Press Reaction Time | Speed to respond correctly to the target- after participant finds the target shape on a computer screen, they press a button to indicate what shape they see | During Testing (single day) | 
| Button Press Accuracy | Accuracy of responses to target item- we will measure whether the participants presses the correct button which corresponds to the target shape presented on the computer screen or the incorrect button | During Testing (single day) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
attention, visual search
Hepatic Hemodynamic Changes and Simulation in Living-Related Liver Transplantation

Study Overview
=================
Brief Summary
-----------------
This 1-year project is intended to study the hemodynamic changes of poratal and hepatic artery during living related liver transplantation. We hypothesize that after right hepatectomy for living related liver transplatation, portal vein overflow will change the remnant liver contour and result in liver hyperplasia.

Detailed Description
-----------------
We use CT as tools to reconstruct 3D images of portal vein and hepatic artery before and one month after operation. The images are transferred to CAD and computer simulation is performed.

Official Title
-----------------
Hepatic Hemodynamic Changes and Simulation Before /After Living-Related Liver Transplantation in Donors/Recipients

Conditions
-----------------
Right Hepatectomy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Informed adult-to adult living donor underwent right lobectomy Exclusion Criteria: no written informed contents

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |