The Role of Music Stimulation in Disorders of Consciousness State: an fMRI Study

Study Overview
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Brief Summary
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The aim of the present study was to evaluated the neural effect of music on the cerebral activation in unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) by using functional magnetic resonance imaging (fMRI).

Detailed Description
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Background: Sensory stimulations were used widely to evaluate the preserved cerebral functions for these patients with disorders of consciousness. Among these, the most alerting or common stimuli are probably familiar voice and music. Objective: The aim of the present study was to evaluated the neural effect of music on the cerebral activation in unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) by using functional magnetic resonance imaging (fMRI). Methods: Eleven severely brain-damaged patients (6 UWS and 5 MCS) were assessed by functional magnetic resonance imaging while they were exposed under the condition of their personal music. To examine the prognostic value of these patients, longitudinal behavioral assessments were repeatedly conducted by means of the CRS-R after fMRI acquisition.

Official Title
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The Role of Music Stimulation in Disorders of Consciousness State: an fMRI Study

Conditions
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Vegetative State, Minimally Conscious State

Intervention / Treatment
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* Diagnostic Test: functional magnetic resonance imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age ≥ 18 years old; no administration of neuromuscular blockers or sedation within the 24 hours of enrolment; brain damage with eye opening (indicating wakefulness and rest cycles) Exclusion Criteria: Coma; neurodegenerative disease; psychiatric or neurologic illness; with intracranial metal or other body metal.

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 61 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients with disorders of consciousness<br>patients with disorders of consciousness from several brain injury have been clinically classified into coma, unresponsive wakefulness syndrome and minimally conscious state. These patients were scaned by functional magnetic resonance imaging. | Diagnostic Test: functional magnetic resonance imaging<br>* Patients with disorders of consciousness were assessed by functional magnetic resonance imaging while they were exposed under the condition of music.<br>* Other names: Coma Recovery Scale-Revised;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Coma Recovery Scale-Revised | examine the prognostic value of these patients, longitudinal behavioral assessments were repeatedly conducted by means of the CRS-R after fMRI acquisition | one to two years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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disorders of consciousness, music stimulation, functional magnetic resonance imaging