The Vascularity Changes of Scars With Laser Therapy

Study Overview
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Brief Summary
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The purpose of this study is to explore the effects of pulsed dye laser on managing scar vascularity and thickness.

Detailed Description
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The pulsed dye laser is increasingly used in clinical settings to manage scars and shows promising outcomes.The pulsed dye laser targets at micro-vascular structures in scar tissues. This study aims to explore the vascularity changes in scars with pulsed dye laser during the scar formation process.

Official Title
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The Vascularity Changes of Scars With Receiving Pulsed Dye Laser

Conditions
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Hypertrophic Scar

Intervention / Treatment
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* Device: pulsed dye laser
* Other: standardized care


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: scars caused by burn injury or related trauma; wound healing days over 3 weeks; days post injury less than 1 year; ability and willingness to comply with all the treatment and assessment procedures. Exclusion Criteria: history of steroid injection or graft surgery; history of keloid scarring; open wound or active infection; conditions that affect wound healing, such as diabetes mellitus.

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Laser group<br>Participants in this group receive pulsed dye laser to treat the scar. | Device: pulsed dye laser<br>* The scar will receive PDL 585 nm using a 7 mm spot size. First treatment will be within 1 year post injury.<br>Other: standardized care<br>* the scar will receive standardized care such as scar massage.<br>|
| Active Comparator: Control group<br>Participants in this group receive standardized care. | Other: standardized care<br>* the scar will receive standardized care such as scar massage.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| scar erythema | Dermoscopy captures the scar photo and measures degrees of scar erythema. | 3 months | 
| scar blood flow | Ultrasound measures blood flow in scar tissues | 3 months | 
| scar thickness | Ultrasound measures scar thickness. | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| patient and observer scar assessment scale (POSAS) | The POSAS measures scar vascularity, pigmentation, pigmentation, thickness, relief, pliability and surface area. Every parameter ranges from 1 to 10, and higher score indicates worse scar performance in that parameter. The total score of POSAS is calculated by summing all the parameters' scores. | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hypertrophic scar, pulsed dye laser