To Study the Effect of β-glucans on Wound Healing

Study Overview
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Brief Summary
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The purpose of this study is to determine the effect of β-glucans on wound healing.

Detailed Description
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The structure of βeta-glucan (β-glucans) is a pathogen associated molecular patterns (pathogen-associated molecular patterns, PAMPs), widely present in the cell walls of plants, bacteria, yeasts, fungi, mushrooms and algae. Modern has been reported in the literature that β-glucan can enhance the immune system of animals, and to enhance the function of the animal against bacterial, fungal and viral infections, and cancer.In this study, the use of β-glucan to enhance the biological characteristics of the non-specific immunity, to explore the impact of postoperative patients with wound healing and infection rates.The observation of the healing process to take the Leather District wounds (5   200 cm2). The experiments were carried out for 18 months, were observed record the following three: (1) the rate of wound healing, (2) The rate of infection assessment: record length of time and the point in time at all levels of antibiotic use also observe the wound change (redness, swelling, heat, pain).(3) days of hospitalization, and spend statistics. Using unpaired student's t-test analysis, group data whether the differences between groups of experimental data. represents a statistically significant when p <0.05.

Official Title
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To Study the Effect of β-glucans on Wound Healing

Conditions
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Burns

Intervention / Treatment
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* Dietary Supplement: oral beta-glucans
* Drug: oral sugar powder


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Total burn area under 20%, two to three degree burn and need skin-grafting. Subjects don't have other diseases. Subjects' age between 20 to 60. Exclusion Criteria: Subjects with hypersensitivity. Subjects with Autoimmune disease.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: oral beta-glucans<br>Daily give kg per day to 30 mg of β-glucan (30mg/kg/day), taking to the wound healed. | Drug: oral sugar powder<br>* 30 mg/kg, oral every day until wound healed completes or unacceptable toxicity develops.<br>* Other names: placebo, sugar, glucose;|
| Placebo Comparator: oral sugar powder<br>control group, daily give and the glucose powder 30 mg per kilogram of body weight (30mg/kg/day) a day, taking to the wound healed. | Dietary Supplement: oral beta-glucans<br>* 30 mg/kg, oral every day until wound healed completes or unacceptable toxicity develops.<br>* Other names: D-glucose polysaccharides;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Wound healing percentage | record data by taking picture | every Monday and Thuresday for the duration of hospital stay, an expected average of 3 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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burn, wound healing, skin graft