Impact Of Post-Bariatric Body Contouring Procedures on Patient Body Weight and Metabolism

Study Overview
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Brief Summary
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Is post-bariatric body contouring surgery prevent weight regain or no, and what is the effect on the patient's Metabolism? Few literature studies report body contouring surgery to be positively associated with maintained weight loss after obesity surgery but the measures of outcomes are diverse, and the collective magnitude of such an association is unknown. The changes in gastrointestinal hormones, adipokines, and cytokines as well as in hypothalamic neuropeptides and neurotransmitters resemble the changes observed in the anorexia/cachexia, suggesting that bariatric surgery triggers a catabolic state responsible for loss of appetite and prolonged body weight reduction. Weight regain after gastric bypass surgery occurs in about half of all patients within 2 years. About 50% of patients eventually gain a little weight back after hitting their low point. We need a more thorough evaluation to determine what factors - medical, psychological, lifestyle - are involved in the weight gain. One of the factors that seem to be responsible for the degree and durability of weight loss is post-bariatric body contouring procedures. However, metabolic consequences of removing excess subcutaneous adipose tissue by body contouring procedures have to a lesser extent been explored

Official Title
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Impact Of Post-Bariatric Body Contouring Procedures on Patient Body Weight and Metabolism

Conditions
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Bariatric Surgery Candidate

Intervention / Treatment
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* Procedure: body contouring


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Post-bariatric (sleeve) patients will do body contouring surgery. Post-bariatric patients has been stable within 5 kg for 3 months Age between 20-60 years old. patients use the determinant fixed diet. Exclusion Criteria: Age below 20 and above 60 years old. Non-compliance with the fixed diet. psychotic patients. Female patients seeking pregnancy. Endocrine causes of obesity. Bariatric surgery other than sleeve.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: group A<br>to know the effect of post-bariatric body contouring surgery on weight loss and metabolism | Procedure: body contouring<br>* any post-bariatric body contouring surgery included<br>|
| No Intervention: group B<br>compare this group of patients with group A to detect weight changes and metabolic changes without any post-bariatric intervention | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| weight changes by kilograms | to know the effect of post-bariatric body contouring surgery in weight. Detect the weight cahnges of the patient every month afer body contouring surgery and body mass index also measured every month for six months | 4 years | 
| Level of Tumor necrotizing factor alfa in blood | Its a clinical laboratory investigation will be done before the body contouring surgeries and 3 and 6 months after. Tumor necrotizing factor alfa increase afer bariatric surgery and we want to know if its complete on increasing after body contouring surgeries or decresae . Tnf-a is measured by pg/ml | 4 years | 
| Level of BNP in blood | Its a clinical laboratory investigation will be done before the body contouring surgeries and 3 and 6 months after. BNP highly increase with catabolism after bariatric surgery and we want to know the effect of body contouring surgeries in the level of BNP. BNP unit is pg/ml | 4 years | 
| Level of high sensitive CRP in blood | Its a clinical laboratory investigation will be done before the body contouring surgeries and 3 and 6 months after. hsCRP increase with catabolism after bariatric surgery and we want to know the effect of body contouring surgeries in blood level of hsCRp. The unit of hsCRP is mg/dl. | 4 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient satisfaction score | From 1 to 5 . 1 very dissatisfied 5 very satisfied Increase in number means increase satisfaction. | 4 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Bariatric, Weight regain, Metabolism