The Benefit of Autologous Blood Transfusion in Total Hip Arthroplasty

Study Overview
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Brief Summary
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The investigators studied the benefit of preoperative autologous blood donation in participants who undergo total hip arthroplasty. Study is made as a prospective and randomized.

Detailed Description
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Total hip arthroplasty is procedure followed with large perioperative and postoperative blood loss. In order to avoid the application of large amounts of allogeneic blood, preoperative autologous blood donation as a tipe of autologous transfusion have been developed. In this study, the investigators studied the benefit of preoperative autologous blood donation in participants who undergo total hip arthroplasty. Study is made as a prospective and randomized. Participants were divided into three groups: the first group donated one dose of autologous blood 14 days preoperatively, the second group donated one dose of autologous blood 72 hours preoperatively and a third group was not donated autologous blood. The blood parameters, hemodynamic stability, bleeding, the need for application of autologous or homologous blood and length of hospital stay were compared.

Official Title
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The Benefit of Autologous Blood Transfusion in Total Hip Arthroplasty

Conditions
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Transfusion, Hip Arthroplasty

Intervention / Treatment
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* Procedure: Preoperative autologous blood donation, 14 days before surgery
* Procedure: Preoperative autologous blood donation, 72 hours before surgery
* Procedure: Without preoperative blood donation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: subject older than 18 years subject has primary coxarthrosis subject has indication for total hip replacement Exclusion Criteria: subject has secondary coxarthrosis subject has need for revision endoprosthesis history of autoimmune, malignancy or coagulation disorder history of myocardial infarct or cerebrovascular insult in last 6 months history of angina pectoris and unregulated hypertension history of renal or liver failure

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Experimental<br>Preoperative blood donations 14 day before total hip replacement procedure Donation of one dose of autologous blood 14 day before total hip replacement procedure | Procedure: Preoperative autologous blood donation, 14 days before surgery<br> <br> |
| Active Comparator: Active comparator<br>Preoperative blood donation 72 hours before total hip replacement procedure Donation of one dose of autologous blood 72 hours before total hip replacement procedure | Procedure: Preoperative autologous blood donation, 72 hours before surgery<br> <br> |
| Other: Other<br>Without preoperative blood donation | Procedure: Without preoperative blood donation<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient red blood cells value | analysis of blood sample day before surgery, 3 hours after surgery, on first, second, fifth postoperative day and on sixth postoperative day | 6 days | 
| Need for autologous blood transfusion | Based on blood count and hemodynamic stability | 6 days | 
| Need for homologous blood transfusion | Based on blood count and hemodynamic stability | 6 days | 
| Patient hemoglobin value | analysis of blood sample day before surgery, 3 hours after surgery, on first, second, fifth postoperative day and on sixth postoperative day | 6 days | 
| Patient hematocrit value | analysis of blood sample day before surgery, 3 hours after surgery, on first, second, fifth postoperative day and on sixth postoperative day | 6 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of hospital stay | measure of length of hospital stay | 6 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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total hip arthroplasty, autologous blood donation