Effects of Cognitive Intervention on Cognition, Mobility and Brain Electrocortical Activity

Study Overview
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Brief Summary
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Within this project the investigators tested the effectiveness of 2-month of computerized cognitive training (CCT) on CogniFit online platform on 77 older adults, which were randomly divided into intervention and control group. The investigators tested close (battery of cognitive functions) and far transfer (postural and mobility control, EEG, blood samples) of the CCT. Additionally, the investigators were interested into seeing a long-lasting effect, therefore participants were brought back to the laboratory 1 year post CCT.

Official Title
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Holistic Approach for Active and Healthy Aging: Physical and Cognitive Activity, and Nutrition

Conditions
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Cognitive Decline, Cognitive Impairment, Aging, Motor Coordination or Function

Intervention / Treatment
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* Other: Computerized cognitive training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: active and healthy older adults with no major health issues members of the Center for Daily Activity Koper (Slovenia) had normal or corrected-to-normal vision; reported no history of cardiovascular, neurological, or psychiatric conditions Exclusion Criteria: younger than 60 smoking; regular alcohol consumption; acute or chronic skeletal, neuromuscular, metabolic and cardiovascular disease condition;

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Participants in the intervention group followed a computerized cognitive training program for 2-months, 3x/week, 40min/session
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention group<br>Participants in the intervention group received 24 sessions of computerized cognitive training, with a total time of 960 min. | Other: Computerized cognitive training<br>* Intervention used CogniFit platform with Personalized brain training sub-option<br>* Other names: cognitive training;|
| Active Comparator: Active control group<br>Participants in the control group attended activities separate activities, such as learning about healthy lifestyle, had cooking and other social lessons for the same amount as the intervention group performed cognitive training. | Other: Computerized cognitive training<br>* Intervention used CogniFit platform with Personalized brain training sub-option<br>* Other names: cognitive training;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in gait speed | The primary outcome is change in gait speed during single- and dual-task conditions from baseline to post-intervention. | up to 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Executive control (Trail-Making Task Forms A and B) | Secondary outcome is change in executive control, measured with TMT A and B tests | up to 8 weeks | 
| Sensorimotor integration measured with EEG/ERP methodology | Secondary outcome is change ERP components P1, N1, P2 and P3 (amplitudes and latencies) | up to 8 weeks | 
| Brain-derived neurotrophic factor (BDNF) extracted from peripheral blood sampling | Secondary outcome is change in plasma BDNF plasma extraction evaluated in pg/mL | up to 8 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cognition, mobility, cognitive reserve, EEG/ERP