Dual Site-Dual Channel Non-invasive Brain Stimulation for Language and Cognitive Function in Healthy Subjects

Study Overview
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Brief Summary
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The aim of this study is to investigate the effect of dual site-dual channel non-invasive brain stimulation for recovery of language and cognitive function in healthy. Simultaneous dual site-dual channel stimulation was applied by using two sets of transcranial direct current stimulation devices. All subjects will go through four conditions of transcranial direct current stimulation with for 30 minutes. Four conditions are 1) Dual stimulation: i) anodal stimulation on left inferior frontal cortex, ii) anodal stimulation on left dorsolateral prefrontal cortex. 2) IFG stimulation: anodal stimulation on left inferior frontal cortex; 3) DLPFC stimulation: anodal stimulation on left dorsolateral prefrontal cortex area. 4) sham stimulation

Official Title
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Effect of Dual Site-Dual Channel Non-invasive Brain Stimulation for Recovery of Language and Cognitive Function in Healthy Subjects

Conditions
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Healthy

Intervention / Treatment
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* Device: IFG stimulation
* Device: DLPFC stimulation
* Device: Sham stimulation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy subjects with age over 19 years old Exclusion Criteria: history of disorders involving central nervous system patients with severe medical or psychiatric disease

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Dual stimulation<br>i) anodal stimulation of left inferior frontal cortex ii) anodal stimulation on left dorsolateral prefrontal cortex | Device: IFG stimulation<br>* stimulating left inferior frontal cortex with transcranial direct current stimulation for 30 minutes<br>Device: DLPFC stimulation<br>* stimulating left dorsolateral prefrontal cortex with transcranial direct current stimulation for 30 minutes<br>|
| Active Comparator: IFG stimulation<br>anodal stimulation of left inferior frontal cortex | Device: IFG stimulation<br>* stimulating left inferior frontal cortex with transcranial direct current stimulation for 30 minutes<br>|
| Active Comparator: DLPFC stimulation<br>anodal stimulation on left dorsolateral prefrontal cortex | Device: DLPFC stimulation<br>* stimulating left dorsolateral prefrontal cortex with transcranial direct current stimulation for 30 minutes<br>|
| Sham Comparator: Sham stimulation<br>sham stimulation | Device: Sham stimulation<br>* sham stimulation over both left inferior frontal cortex and dorsolateral prefrontal cortex<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Korean Boston naming test | measures naming ability thorough picture naming test | Baseline and after intervention (approximately 30 minutes) | 
| Verbal 3 back test | measure working memory | Baseline and after intervention (approximately 30 minutes) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Korean Color Word Stroop test | measures selective attention and executive function | Baseline and after intervention (approximately 30 minutes) | 
| Controlled Oral Word Association Test | measure verbal fluency | Baseline and after intervention (approximately 30 minutes) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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transcranial direct current stimulation, motor function