Valuation in Depressed Mood, Anhedonia, and Anxiety

Study Overview
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Brief Summary
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This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety.

Detailed Description
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This study tests relationships among neural and behavioral valuation mechanisms, and how these mechanisms change (or not) over time, with task instructions, and following cognitive behavior therapy.

Official Title
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Evaluating Overlap and Distinctiveness in Neurocomputational Loss and Reward Elements of the RDoC Matrix

Conditions
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Neurobehavioral Components of Reward and Loss Valuation

Intervention / Treatment
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* Behavioral: cognitive behavioral therapy
* Behavioral: valuation with instruction
* Behavioral: valuation without instruction


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: mood, anxiety, or anhedonia symptoms that affect functioning; fluent in English; able to see computer display; able to perform simple computer games. Exclusion Criteria: history of seizure disorder, stroke, or head injury with more than 10 minutes of unconsciousness; hormone disorder; electroconvulsive therapy within 5 years; history of chemotherapy for cancer; current pregnancy; contraindications to MRI

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Cognitive behavioral therapy<br>cognitive behavioral therapy for depression, anxiety, and/or anhedonia | Behavioral: cognitive behavioral therapy<br>* cognitive behavioral therapy<br>|
| Active Comparator: Valuation with instruction<br>repeat laboratory sessions of a reward/loss learning computer game with specific instructions | Behavioral: valuation with instruction<br>* repeat laboratory sessions of computerized learning game<br>|
| Active Comparator: Valuation without instruction<br>repeat laboratory sessions of a reward/loss learning computer game without specific instructions | Behavioral: valuation without instruction<br>* repeat laboratory sessions of computerized learning game<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in proportion correct on the 'N-arm bandit learning task' | change in proportion correct on 'N-arm bandit reinforcement learning task' from study entrance to study exit | study entrance to study exit, an average of 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in depression symptoms (Beck Depression Inventory) | change in depression symptoms from study entrance to study exit | study entrance to exit, an average of 12 weeks | 
| change in anxiety symptoms (anxiety subscale; Mood and Anxiety Symptom Questionnaire) | change in anxiety symptoms from study entrance to study exit | study entrance to exit, an average of 12 weeks | 
| change in anhedonia symptoms (anhedonia subscale; Mood and Anxiety Symptom Questionnaire) | change in anhedonia symptoms from study entrance to study exit | study entrance to exit, an average of 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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depression, anxiety, anhedonia