The European Prospective Investigation Into Cancer in Norfolk Prospective Population Study

Study Overview
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Brief Summary
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The European Prospective Investigation into Cancer and Nutrition in Norfolk is a population based prospective study of approximately 25,000 men and women resident in Norfolk United Kingdom. They were aged 39-79 years when first recruited from general practice age sex registers at baseline assessment 1993-1997. While part of a ten country half million participant European collaboration originally aimed to investigate diet and other lifestyle determinants of cancer, the objectives of the Norfolk cohort from inception were expanded to encompass the trajectory of health, ill health and mortality in a population over time and to examine the biological and lifestyle determinants of health and chronic disease.

Detailed Description
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The European Prospective Investigation into Cancer and Nutrition in Norfolk is a population based prospective study of approximately 25,000 men and women resident in Norfolk United Kingdom. They were aged 39-79 years when first recruited from general practice age sex registers at baseline assessment 1993-1997. While part of a ten country half million participant European collaboration originally aimed to investigate diet and other lifestyle determinants of cancer, the objectives of the Norfolk cohort from inception were expanded to encompass the trajectory of health, ill health and mortality in a population over time and to examine the biological and lifestyle determinants of health and chronic disease. Detailed data on sociodemographic, lifestyle, medical and family history were collected and a biological sample bank including urine and blood samples established. Participants have been followed up through repeat examinations, mailed questionnaires as well as through record linkage with routine health records including death certification by cause, cancer registration and hospital admissions by cause till present.

Official Title
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The European Prospective Investigation Into Cancer in Norfolk Prospective Population Study

Conditions
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Death, Neoplasms, Cardiovascular Diseases

Intervention / Treatment
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* Behavioral: diet


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Willing to participate On general practice age sex registers in Norfolk, United Kingdom in 1993-1997 Exclusion Criteria: Not willing to participate in study terminal illness

Ages Eligible for Study
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Minimum Age: 39 Years
Maximum Age: 79 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: diet|lifestyle factors|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| neoplasms | cancer incidence | Through 25 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cardiovascular diseases | incidence of cardiovascular diseases | through 25 years | 
| death | total mortality by cause | through 25 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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nutrition, physical activity, lifestyle, smoking