Echocardiographic Assessment of the Right Ventricle in Healthy Subjects During Stress Test in the Mexican Population

Study Overview
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Brief Summary
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The echocardiographic indices of the right ventricle function vary significantly with demographic and anthropometric of each population factors and are associated with poor prognosis in several cardiovascular diseases. This study aims to investigate exercise-induced changes in echocardiographic indices of the right ventricle function in healthy volunteers and establish the reference values to the Mexican population.

Official Title
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Echocardiographic Assessment of the Right Ventricle in Healthy Subjects During Stress Test in the Mexican Population

Conditions
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Echocardiography, Stress, Reference Values

Intervention / Treatment
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* Diagnostic Test: Stress echocardiography with semi-supine bicycle


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy men or women Age ≥18 years and < 45. No history or symptoms of cardiovascular or lung disease No cardiovascular risk factors, that is, arterial systemic hypertension, smoking, diabetes, dyslipidemia No ongoing or previous cardio or vasoactive treatment Normal ECG Normal physical examination Able to use the semi-supine exercise bicycle Able to give informed consent Exclusion Criteria: Tricuspid regurgitation more than mild Poor acoustic window. Professional sports activity Pregnancy Obesity (body mass index [BMI], ≥30 kg/m2). No knowledge of serum lipid or glucose levels at any time Inability to provide consent

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Stress echocardiography with semi-supine bicycle|The patient is accelerating against a workload that gradually increases at a constant rate, during the exercise the images will be obtained by echocardiography. The patient begins with 25 Watts with increments of 25 Watts every 3 minutes, continuing the exercise until significant electrocardiographic changes occur or the patient starts with symptoms.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Response of diastolic and systolic function of the right ventricle during stress test by echocardiography in a healthy Mexican Cohort | The following variants will be measured by echocardiography during rest and peak exercise Left atrium (LA) LA volume index Left ventricle (LV) LV telediastolic diameter LV telesystolic diameter LV posterior wall Right atrium (RA) RA area Right ventricle (RV) RV basal dimensión RV mid cavity dimension; RV longitudinal dimension Distal, RV outflow tract dimension at the distal or pulmonic valve level Proximal RV outflow tract dimension at the proximal subvalvular level Tricuspid annular plane systolic excursion RV free Wall strain Inferior cava vein PW Doppler E wave mitral A wave mitral E wave /A wave mitral E-wave at mitral annulus (cm/s) E-wave at mitral annulus / A-wave at the mitral annulus E wave/ E-wave at the mitral annulus E tricuspid (E) A tricuspid (A) E/A E-wave at the tricuspid annulus Systolic pulmonary artery pressure Mean pulmonary artery pressure Stroke volume Cardiac output | 1 hour | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Echocardiography, Stress, Right ventricle, Mexican population