Development of a New Neuroimaging Method Aimed to Differentiate Mnesic Abilities of Alzheimer and Depressed Patients

Study Overview
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Brief Summary
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The purpose of this study is to use a new method to differentiate mnesic abilities of early alzheimer patients and patients with a depressive disorder. This method is based on the recording of cerebral activity while patients listen to familiar, unfamiliar and newly-learned music.

Official Title
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Development of a New Neuroimaging Method Aimed to Differentiate Mnesic Abilities of Alzheimer and Depressed Patients

Conditions
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Alzheimer Disease, Depression

Intervention / Treatment
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* Device: high-density electroencephalography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Being right-handed recorded consent For Alzheimer patients: Mini Mental Status Examination (MMSE) score >= 18 For patients with a depressive disorder : Major Depressive Disorder according to Diagnostic and Statistical Manual of Mental Disorders (DSM IV) and Montgomery-Asberg depression rating scale (MADRS) score >= 25 For healthy controls : no cognitive deficit, MADRS score < 25, no depressive disorder according to DSM IV Exclusion Criteria: Auditory deficit contraindication to a high-density electroencephalography exam refusal to participate in the study

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Alzheimer patients<br>Cerebral measurements from high-density electroencephalography are recorded in Alzheimer patients. The same protocol is applied in the 3 arms | Device: high-density electroencephalography<br>* Musical stimulation during electroencephalography recording<br>|
| Experimental: patients with a depressive disorder<br>Cerebral measurements from high-density electroencephalography are recorded in patients with a depressive disorder. The same protocol is applied in the 3 arms | Device: high-density electroencephalography<br>* Musical stimulation during electroencephalography recording<br>|
| Active Comparator: Healthy controls<br>Cerebral measurements from high-density electroencephalography are recorded in healthy controls | Device: high-density electroencephalography<br>* Musical stimulation during electroencephalography recording<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Amplitude of event-related potentials | Measurements of the amplitude of event-related potentials with electroencephalography at day one for familiar and unfamiliar songs and after 2 weeks for newly learned songs | day 1 for familiar and unfamiliar songs and day 14 for newly learned songs | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Spectral power | Measurements of the spectral power with electroencephalography at day one for familiar and unfamiliar songs and after 2 weeks for newly learned songs | day 1 for familiar and unfamiliar songs and day 14 for newly learned songs | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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electroencephalography (EEG)