Sensitivity of Multiparametric MRI in Differentiation Between Muscle Invasive and Non-muscle Invasive Urinary Bladder Cancer

Study Overview
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Brief Summary
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Differentiation between non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC) is a cornerstone in the treatment plans.Therefore, this study will try to evaluate the sensitivity and reliability of mpMRI in accurate diagnosis of cancer bladder. Primary objective: to detect the sensitivity of multiparametric MRI in differentiation between muscle Invasive and non-muscle invasive Urinary Bladder Cancer in relation to the conventional cystoscopy and histopathological examination of the biopsy.

Official Title
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Sensitivity of Multiparametric MRI in Differentiation Between Muscle Invasive and Non-muscle Invasive Urinary Bladder Cancer

Conditions
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Cancer, Bladder

Intervention / Treatment
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* Radiation: multiparametric MRI on the bladder
* Procedure: diagnostic cystoscopy +/- TURBT


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients diagnosed with NMIBC or MIBC during diagnostic cystoscopy or by any radiologic investigation in the Urology department of Helwan university hospitals without being restricted to age or sex. All histological types of bladder cancer Newly diagnosed, recurrent cases, or even patients undergoing follow-up cystoscopy. Exclusion Criteria: Patients with elevated renal function according to their age as this will be a contraindication to DCE MRI. Patients with absolute contraindication to MRI (e.g.: metallic prosthesis). Patients with contraindication to undergo TURBT (e.g.: unfit for surgery).
Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| muscle invasive cancer bladder<br> | Radiation: multiparametric MRI on the bladder<br>* comparison between mpMRI and histopathology<br>Procedure: diagnostic cystoscopy +/- TURBT<br>* conventional way of diagnosis<br>|
| non-muscle invasive cancer bladder<br> | Radiation: multiparametric MRI on the bladder<br>* comparison between mpMRI and histopathology<br>Procedure: diagnostic cystoscopy +/- TURBT<br>* conventional way of diagnosis<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| to detect the sensitivity of multiparametric MRI in differentiation between muscle Invasive and non-muscle invasive Urinary Bladder Cancer in relation to the conventional cystoscopy and histopathological examination of the biopsy. |  | 6 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the sensitivity of mpMRI to detect non-visible lesions during follow up cystoscopy while mpMRI reports a positive lesion. |  | 6 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cancer bladder, multiparametric MRI, VIRADS score