linjc16/ctgov huggingface dataset:
Cross-over Comparison of Gabapentin and Memantine as Treatment for Acquired Nystagmus

Study Overview
=================
Brief Summary
-----------------
Involuntary oscillations of the eyes (nystagmus) impairs vision so that affected patients, who have neurological disorders such as Multiple Sclerosis (MS) , cannot read or watch TV. Two medicines have been reported to suppress nystagmus and improve vision in such patients: gabapentin and memantine. The investigators set out to test which of these two drug was more effective by carrying out a double-blind cross-over study. In this way, we could determine which drug worked best in each patient.

Detailed Description
-----------------
The study entails careful measurements of visual acuity and precise measurements of eye movements, using a contact lens device (magnetic search coil method). In this way, it is possible to make objective and reliable measurements of the effect of each drug, which are unbiased by the investigator or the patient.

Official Title
-----------------
Investigation and Treatment of Ocular Motor Disorders: Cross-over Comparison of Gabapentin and Memantine as Treatment for Nystagmus

Conditions
-----------------
Nystagmus

Intervention / Treatment
-----------------
* Drug: gabapentin
* Drug: memantine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult (18 years or older) males or females with acquired nystagmus that is degrading their vision Exclusion Criteria: Pregnant women Individuals who cannot describe their visual symptoms, cooperate with testing, or give informed consent Individuals with intolerance of gabapentin or memantine

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Gabapentin<br>Increasing dose to 300 mg four times per day (total of 1200 mg/day) | Drug: gabapentin<br>* increasing to 1200 mg/day<br>* Other names: Neurontin;|
| Active Comparator: Memantine<br>Increasing dose over two weeks to 20 mg twice/day (total of 40 mg/day). | Drug: memantine<br>* increasing to 40 mg/day<br>* Other names: Nameda;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in logMAR Visual Acuity of Each Eye, Measured During Far or Near Viewing |  | After 2 weeks of therapy, for both drugs | 
| Percent Change in Median Eye Speed | Median eye speed during attempted visual fixation by each eye | After 2 weeks of therapy, for both drugs | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
gabapentin, memantine, nystagmus, Drug treatment
Cardiovascular Disease Risk Factors in Chinese American Immigrants

Study Overview
=================
Brief Summary
-----------------
The Chinese population is currently the fastest growing ethnic group in New York City (NYC). Research has shown that Chinese immigrants living in NYC have higher rates of cardiovascular disease (CVD) than individuals in China. This study will evaluate the effect that acculturation has on health habits and CVD risk factors in Chinese immigrants living in NYC.

Detailed Description
-----------------
CVD includes diseases that affect the heart and blood vessels. The underlying cause of CVD is atherosclerosis, in which fatty plaques develop on the inner walls of arteries. There are many risk factors for CVD, including inflammation, high blood pressure, high cholesterol, and obesity. Research has shown that CVD mortality rates differ greatly between Chinese immigrants living in NYC and individuals living in China. Because of this difference, it is important to understand the impact of immigration and acculturation on health habits and psychosocial factors, which may influence the development of CVD. This study will gather information from Chinese immigrants in NYC to identify the impact of immigration and acculturation on behavior and CVD risk factors. In addition, results from this study may provide insight into the CVD risk patterns in other immigrant groups. This study will enroll Chinese immigrants living in NYC. Participants will attend one study visit and will complete questionnaires to assess their health habits (diet, physical activity, and smoking), stress levels, and socioeconomic status. Participants will also undergo a physical examination and blood collection.

Official Title
-----------------
Chinese American Cardiovascular Health Assessment CHA-CHA

Conditions
-----------------
Hypertension, Cardiovascular Diseases, Diabetes Mellitus, Metabolic Syndrome X

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Chinese immigrant Currently residing in NYC Exclusion Criteria: Under 18 years of age Not of Chinese dissent Born outside mainland China

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants With Hypertension | Systolic BP above 129 or Diastolic BP above 79. | 4 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Obesity, Blood Pressure, High, Tobacco Use Disorder
Salivary Gland Transplantation in the Treatment of Dry Eye in Patients With Stevens-Johnson Syndrome.

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate salivary gland and labial mucous membrane transplantation in patients with severe symblepharon and dry eye secondary to Stevens-Johnson Syndrome (SJS).

Detailed Description
-----------------
This study was performed to evaluate the use of salivary gland and labial mucous membrane transplantation in patients with severe symblepharon and dry eye secondary to SJS. Labial mucous membrane and salivary gland transplantation showed to be a good option in the treatment of severe symblepharon and dry eye secondary to SJS. labial mucous membrane, salivary glands, symblepharon, entropion, transplantation, graft.

Official Title
-----------------
Salivary Gland and Labial Mucous Membrane Transplantation in the Treatment of Severe Symblepharon and Dry Eye in Patients With Stevens-Johnson Syndrome.

Conditions
-----------------
Symblepharon, Dry Eye, Ocular Surface Disease, Transplantation

Intervention / Treatment
-----------------
* Procedure: Salivary Gland and Labial Mucous Membrane Transplantation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Only patients with poor visual acuity, less or equal to 20/200, and Schirmer I test equal to zero. Eyes with symblepharon or ankyloblepharon that did not allow the placement of a Schirmer test strip will be consider not measurable. Exclusion Criteria: Active infection and corneal melting or perforation.

Ages Eligible for Study
-----------------
Minimum Age: 10 Years
Maximum Age: 58 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Salivary Gland and Labial Mucous Membrane Transplantation<br> | Procedure: Salivary Gland and Labial Mucous Membrane Transplantation<br>* Minor salivary glands (SG) will be obtain en block from the same donor site, at the inferior or superior labial mucous membrane, above the orbicularis oris muscle to correct lubrication. The thin split thickness graft of mucous membrane will be suture to the sclera with absorbable sutures<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| A Complete ophthalmic exam including Schirmer I test , slit lamp exam, fundoscopy will be perform before and six months after surgery. Symptons improvement considered positive if patients will refer improvement of eye moisturasing and motility. |  | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Labial mucous membrane, symblepharon, dry eye, Stevens -Johnson syndrome, salivary gland, ocular surface disease, transplantation
A Smartphone-based Application Post-myocardial Infarction to Manage Cardiovascular Disease Risk

Study Overview
=================
Brief Summary
-----------------
The investigators aim to evaluate Wellframe, a patient engagement platform that includes a mobile phone application for patients, for its impact on supporting patients who have undergone a percutaneous coronary intervention. The patient mobile app has articles about cardiovascular disease and other health related topics, patient-reported outcomes surveys, physical activity tracking, reminders for medications and upcoming appointments, and two-way communication with a Wellframe Health Advocate. The Wellframe Health Advocate encourages patients to achieve their health goals and stay engaged in their health. The feasibility of onboarding patients to the app and the clinical efficacy of the platform will be evaluated.

Official Title
-----------------
A Smartphone-based Application Post-myocardial Infarction to Manage Cardiovascular Disease Risk

Conditions
-----------------
Percutaneous Coronary Intervention

Intervention / Treatment
-----------------
* Other: Wellframe


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: English-speaking PCI: balloon angioplasty, bare-metal stent, or drug-eluting stent at MGH Smartphone or Tablet (iOS or Android) Exclusion Criteria: Recent (within 1mo) illicit substance use or alcohol abuse In-hospital AMI Known pregnancy Dementia or cognitive disability Incarceration

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Interventional Model Description: Enroll and onboard 150 patients with the Wellframe application
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Wellframe<br>Subjects in this arm will use the Wellframe application for 90 days | Other: Wellframe<br>* Wellframe mobile phone app<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants With Readmission at 30 Days | How many subjects were readmitted to the hospital | 30 Days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants With Readmission at 90 Days | How many subjects were readmitted to the hospital | 90 Days | 
| Number of Participants Enrolled in Clinic-based Cardiac Rehab at 90 Days | Percent of patients discharged after intervention who attend at least one session of clinic-based cardiac rehab | 90 days |
Detecting Delayed Discharge in Acute Geriatric Unit Using Natural Language Processing

Study Overview
=================
Brief Summary
-----------------
Delayed discharge in geriatric units is a health and economic issue. There is no algorithm to automatically measure the appropriateness of admissions or hospital days. 30% of the days of hospitalization in acute geriatric units (AGU) are not appropriate. Waiting for a transfer to a follow-up care and rehabilitation unit (SSR) is the main risk factor for inappropriate days. The purpose of this project is to develop an algorithm using natural language processing to predict the appropriateness of an admission to UGA, or a day at UGA.

Official Title
-----------------
Detecting Delayed Discharge in Acute Geriatric Unit Using Natural Language Processing

Conditions
-----------------
Language, Geriatric, Older, Electronic Health Record

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age : >75 years patient hospitalized in an AGU Exclusion Criteria: refusal to participate

Ages Eligible for Study
-----------------
Minimum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Concordance between Appropriateness Evaluation Protocol algorithm prediction result and real admission in AGU | AGU is acute geriatric units | 15 days | 
| Concordance between Appropriateness Evaluation Protocol algorithm prediction result and real admission for one day in AGU | AGU is acute geriatric units | one day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Natural Language Process, appropriate stay, acute geriatric unit, older, Electronic Health Record.
Epidemiology of Human Cytomegalovirus Excretion in the Saliva of Children Attending Nursery in France

Study Overview
=================
Brief Summary
-----------------
Direct DNA amplification, viral isolation and specific antibody measurement in saliva from children attending nursery in France Sample collection will be done by the pediatrician the nurse, or one of the authorized investigators of the study.

Detailed Description
-----------------
Salivary collection kit. 3 swab for DNA research, 1 for antibodies research and 1 for virus isolation by cell growth.

Official Title
-----------------
Epidemiology of Human Cytomegalovirus Excretion in the Saliva of Children Attending Nursery in France.

Conditions
-----------------
Healthy Volunteers

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children older than 3 months and less than 6 years kept in nurseries retained, regardless of the duration of custody of the child in the manger concerned. Exclusion Criteria: Refusal of parents (lack of consent) Refusal of the child according to his ability to understand Uninsured social security

Ages Eligible for Study
-----------------
Minimum Age: 3 Years
Maximum Age: 6 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Child in nursery<br>Children older than 3 months and less than 6 years kept in nurseries retained, regardless of the duration of custody of the child in the manger concerned. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Identification of viral shedding | Saliva using small sponges, non-invasive for the viral genome, isolating virus strains and measurement of antibody IgG and IgA. | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluate the distribution of different genotypes of strains of CMV | distribution by genotype strains found | 1 day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
CMV, Children, nursery, Infection
Peristomal Mesh for Prophylaxis of Parastomal Hernia

Study Overview
=================
Brief Summary
-----------------
The study aims to prove differences or equalities in outcome for patients operated with or without a peristomal mesh in the sublay position when establishing a permanent colostomy.

Detailed Description
-----------------
Patients are randomized to 2 groups equal in number: a group with mesh implantation and a control group without mesh implantation. Primary endpoint is Parastomal hernia. Secondary endpoints are operating time, infection, obstruction, stenosis, retraction, fistulae, skin related problems and reoperations. Endpoints are correlated to body mass index, previous hernia, age, concurrent illness and cause for colostomy. Patients are followed 4 years after operation with clinical examination

Official Title
-----------------
Randomized Controlled Open Interventional Study for Evaluation of Use of Peristomal Mesh for Prophylaxis of Parastomal Hernia

Conditions
-----------------
Hernia

Intervention / Treatment
-----------------
* Device: Mesh in permanent colostomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Condition with indication for establishing a permanent end-colostomy. Exclusion Criteria: Age under 18 ASA score above 3
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Prophylactic stoma mesh<br>Mesh | Device: Mesh in permanent colostomy<br> <br> |
| Active Comparator: No mesh prophylaxis<br>No mesh | Device: Mesh in permanent colostomy<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Parastomal hernia |  | at 3, 12, 24, 36 and 48 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Operating time, infection, obstruction, stenosis, retraction, fistulae, skin related problems and reoperations. Endpoints are correlated to body mass index, previous hernia, age, concurrent illness and cause for colostomy |  | 4 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
colostomy, parastomal, peristomal, hernia, mesh, surgery, Indication for permanent end colostomy
Analgesic Effect of Adding an Adductor Canal Block to a Femoral Triangle Block for Total Knee Replacement

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to investigate whether the addition of an adductor canal block to a femoral triangle block will provide better analgesia for patients after total knee replacements.

Official Title
-----------------
A Randomised Controlled Trial Investigating the Addition of an Adductor Canal Block to a Femoral Triangle Block for Analgesia After Total Knee Replacement

Conditions
-----------------
Total Knee Replacements

Intervention / Treatment
-----------------
* Procedure: Adductor canal block
* Procedure: Femoral triangle block


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients undergoing total knee arthroplasty under spinal anaesthesia 45y or older ASA 1-3 BMI 18-35 Exclusion Criteria: Unable to consent Chronic opioid consumption Allergy to study medication Lower limb surgery preceding year Unable to complete baseline testing, pre-existing neurological deficit Contraindication to spinal anaesthesia

Ages Eligible for Study
-----------------
Minimum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: RCT
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention<br>Adductor canal block Femoral triangle block | Procedure: Adductor canal block<br>* Single shot block with 0.5% bupivacaine 10mls<br>Procedure: Femoral triangle block<br>* Single shot block with 0.5% bupivacaine 10mls<br>|
| Active Comparator: Standard<br>Femoral triangle block | Procedure: Femoral triangle block<br>* Single shot block with 0.5% bupivacaine 10mls<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Opioid consumption | Morphine | 24 hours | 
| Opioid consumption | Morphine | 48 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle strength | measured with dynanometer | 24 hours | 
| Muscle strength | measured with dynanometer | 48 hours | 
| Time to up and go test | Time to get up from chair, walk 3 meters and return to chair | 24 hours | 
| Time to up and go test | Time to get up from chair, walk 3 meters and return to chair | 48 hours | 
| 30 Chair stand test | Number of times a patient can stand up from sitting position in 30 seconds | 24 hours | 
| 30 Chair stand test | Number of times a patient can stand up from sitting position in 30 seconds | 48 hours |