Muscle Atrophy In Patients With Chronic Obstructive Pulmonary Disease

Study Overview
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Brief Summary
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Limb muscle dysfunction, characterized by atrophy and weakness, is amongst the most troublesome systemic consequences of chronic obstructive pulmonary disease (COPD) leading to poor functional status and premature mortality. One prevailing hypothesis stipulates that the deterioration in muscle structure and function during COPD results from a spillover of inflammatory mediators from the lungs to the systemic circulation and then to the muscles.

Detailed Description
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The investigators objective is to investigate the impact of COPD on key signaling pathways involved in the muscle atrophy. Moderate to severe COPD patients (FEV1 under 60% of predicted) and healthy controls will be recruited. All of the investigators patients will undergo a thorough baseline assessment in pulmonary capacity, muscle force and body composition. Blood sampling and biopsy of the quadriceps will be done. Key proteins of signaling intramuscular pathways involved in protein synthesis and degradation will be measured in the quadriceps.

Official Title
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Muscle Atrophy In Patients With Chronic Obstructive Pulmonary Disease

Conditions
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Chronic Obstructive Pulmonary Disease

Intervention / Treatment
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* Other: No specific intervention for this study


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: male COPD with an FEV1 of under 60% of predicted non-smoker between 55 and 75 years old Exclusion Criteria: all inflammatory disease (HIV, cancer, renal and cardiac deficiency) hormonal dysregulation inferior limb pathology neuromuscular pathology history of tobacco or alcool abuse oxygen dependent recent exacerbation (2 months) of the symptoms of COPD

Ages Eligible for Study
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Minimum Age: 55 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COPD patients<br>Group : COPD patients No specific intervention for this study | Other: No specific intervention for this study<br>* No specific intervention for this study<br>|
| Healthy controls<br>Group : healthy volunteers No specific intervention for this study | Other: No specific intervention for this study<br>* No specific intervention for this study<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Decrease of protein degradation in muscles of wasted COPD patients |  | At baseline (COPD in a stable state of the disease) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Increase of protein synthesis in muscles of wasted COPD patients |  | At baseline (COPD in a stable state of the disease) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COPD, atrophy, muscle