Computer-based Dosage Calculation for Antibiotics

Study Overview
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Brief Summary
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Adequate dosing of antiinfective therapy in critically ill patients with impaired or lost renal function or continuous renal replacement therapy is nearly impossible without measuring the drug concentration in blood samples. In many hospitals that is still not an option. The investigators aim to show, that computer based calculation can avoid over- or under-dosing.

Detailed Description
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Adequate dosing of antiinfective therapy in critically ill patients is most important to improve outcome. Patients with impaired or lost renal function or continuous renal replacement therapy are hard to calculate using drug information sheets or lists with recommendations. It is nearly impossible to avoid drug levels that are much to low or much to high without measuring the concentration in blood samples. Since that possibility is still not available in every clinic we aim to show, how a computer based calculation can help to find the adequate dosing.

Official Title
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Computer-basierte Dosierungsregime Von Antiinfektiva Bei eingeschränkter Nierenfunktion Und Kontinuierlichen Nierenersatztherapieverfahren (Computer-based Dosage Calculation for Antibiotics in Patients With Impaired Renal Function or Renal Replacement Therapy)

Conditions
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Acute Kidney Insufficiency, Anti-Infective Agent Toxicity

Intervention / Treatment
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* Drug: Piperacillin/tazobactam
* Drug: Meropenem


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients requiring antiinfective therapy patients with impaired renal function or requiring continuous renal replacement therapy Exclusion Criteria: plasmapheresis or liver replacement therapy renal replacement therapy with integrated CytoSorb®-Membrane extracorporal live support

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Piperacillin/Tazobactam<br>Group of patients receiving Piperacillin/Tazobactam as antiinfective therapy | Drug: Piperacillin/tazobactam<br>* antiinfective therapy with Piperacillin/Tazobactam within routine care<br>|
| Meropenem<br>Group of patients receiving Meropenem as antiinfective therapy | Drug: Meropenem<br>* antiinfective therapy with Meropenem within routine care<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| drug levels (blood) | achieved drug levels in blood samples | 3 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| dosing changes | dose adjustments to the computer based calculated regiments | 3 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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renal replacement therapy