Variability of SpO2 Measurements Depending on the Choice of Finger for Sensor Placement

Study Overview
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Brief Summary
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The aim of the project is to experimentally determine the effect of the choice of finger for the placement of a pulse oximeter sensor on the results of measuring peripheral blood oxygen saturation (SpO2) in a healthy person with short-term hypoxia and hypercapnia.

Detailed Description
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The aim of the project is to experimentally determine the effect of the choice of finger for the placement of a pulse oximeter sensor on the results of measuring peripheral blood oxygen saturation (SpO2) in a healthy person with short-term hypoxia and hypercapnia. This is an intervention prospective study that will take place at the Faculty of Biomedical Engineering, especially on FBMI students. The experiment consists of two phases, in which in the first phase, the volunteers will inhale the hypoxic mixture for five minutes after the stabilization phase. In the second phase, volunteers inhale a hypoxic and hypercapnic mixture. During the experiment, non-invasive SpO2 measurements will be performed continuously on individual fingers of both volunteer hands.

Official Title
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Variability of SpO2 Measurements Depending on the Choice of Finger for Sensor Placement

Conditions
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Hypoxia, Hypercapnia

Intervention / Treatment
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* Other: Breathing a mixture of O2, N2 and CO2 and monitoring SpO2 on each finger


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Passing the initial examination, which will determine the following data: finger circumference, heart rate, blood pressure and blood oxygen saturation Exclusion Criteria: post-traumatic conditions of the upper limbs affecting the perfusion of the fingers or injuries or skin diseases on the fingers. pneumothorax or a condition after cardiovascular surgery. anemia, bradycardia, hemoglobinopathy or other diseases of the cardiovascular system, pregnancy, diabetes, hypotension or hypertension.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: Interventional single blinded randomized crossover prospective study
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Hypoxic<br>In this phase, participants inhale the hypoxic mixture for five minutes. | Other: Breathing a mixture of O2, N2 and CO2 and monitoring SpO2 on each finger<br>* The experiment consists of two separate phases. In one phase, the volunteers inhale one of the mixtures for five minutes. After enough time of recovery, the volunteers undergo the other phase in which they inhale the other mixture of gases. Both phases of the measurement will begin with a two-minute stabilization phase, during which the physiological values of the volunteer will be checked. During the experiment, non-invasive SpO2 measurements will be performed continuously on the individual fingers of both volunteer hands throughout the experiment.<br>|
| Experimental: Hypoxic and Hypercapnic<br>In this phase, participants inhale the hypoxic and hypercapnic mixture for five minutes. | Other: Breathing a mixture of O2, N2 and CO2 and monitoring SpO2 on each finger<br>* The experiment consists of two separate phases. In one phase, the volunteers inhale one of the mixtures for five minutes. After enough time of recovery, the volunteers undergo the other phase in which they inhale the other mixture of gases. Both phases of the measurement will begin with a two-minute stabilization phase, during which the physiological values of the volunteer will be checked. During the experiment, non-invasive SpO2 measurements will be performed continuously on the individual fingers of both volunteer hands throughout the experiment.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Does it depend on which finger is the sensor placed for SpO2 values? | The experiment can help determine if it depends on which finger the finger sensor will be placed to measure SpO2. Appropriate finger selection for SpO2 measurements could help to better interpret the measured values and possibly increase the success in diagnosing health events. | Up to 12 weeks |