ICU Norepinephrine Load

Study Overview
=================
Brief Summary
-----------------
Norepinephrine is recommended as first-line vasopressor in critically ill patients, regardless of shock etiology. Its advantages over dopamine and/or epinephrine have been demonstrated, especially by reducing tachycardia events. The current guidelines recommend a mean arterial pressure of at least 65 mmHg that in the resuscitation from sepsis-induced hypoperfusion. Some study reported that delay in initiation of vasopressor therapy was associated with an increase mortality risk in patient with septic shock .The recent experts' opinion suggest that  vasopressors should be started early, before (complete) completion of fluid ressuscitation . In the event of refractory septic shock, high-dose vasopressors may be used. The precise maximal dose of norepinephrine associated with mortality excess has been poorly studied. High doses have been defined by a cutoff value ranging from 0.5 μg/kg/min to 2 μg/kg/min and recently by 1 μg/kg/min for mortality at 90% and by 0,75 μg/kg/min for mortality at 60%. Furthermore, an increasing vasopressor dosing intensity during the first 24 hours after shock septic was associated with increased mortality depending of fluid administration. If a threshold value of norepinephrine score can be obtained, it could indicate the association with another vasopressor such as vasopressin or surrogates. The primary aim of the present study aimed to confirm if a given norepinephrine dose is associated with mortality. The secondary aims were the link between mortality and norepinephrine duration, cumulative dose in order to build a score that predicts a futility of increasing norepinephrine dose.

Official Title
-----------------
Norepinephrine Load and Relationship With Prognosis in Critically Patients With Circulatory Shock

Conditions
-----------------
Circulatory Collapse and Shock

Intervention / Treatment
-----------------
* Drug: Circulatory shock with norepinephrine in ICU


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age > 18 years circulatory shock and admitted in ICU with norepinephrine Exclusion Criteria : Patient without norepinephrine or missing data.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1: surviving Patients<br>Patients surviving within 5 days of the date of ICU admission for circulatory shock and receiving norepinephrine | Drug: Circulatory shock with norepinephrine in ICU<br>* Circulatory shock with norepinephrine in ICU<br>|
| Group 2: Deceased patients<br>Patients deceased within 5 days of the date of ICU admission for circulatory shock and receiving norepinephrine | Drug: Circulatory shock with norepinephrine in ICU<br>* Circulatory shock with norepinephrine in ICU<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | Mortality within 5 days of the date of ICU admission for circulatory shock according to norepinephrine intensity | Day 5 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intensity | Intensity mortality relationship according to norepinephrine duration | Day 5 | 
| Time/Dose Ratio | ratio between time of use and cumulative dose | Day 5 | 
| Norepinephrine dose | score of increasing norepinephrine dose | Day 5 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
vasopressor dose intensity, Norepinephrine load dose, vasopressor exposure