Influence of Mango Intake of Skin Health in Postmenopausal Women

Study Overview
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Brief Summary
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This study aims to investigate the effects on 16 weeks of mango intake on skin health in postmenopausal women. Half of the participants will receive 85g portions of mangoes while the other half receive 250g portions of mangos. Participants will be instructed to consume the specific portion 4 times a week, for a total duration of 16 weeks.

Detailed Description
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Mangoes are rich in carotenoids, flavonoids, vitamins and other active phytochemicals such as resistant starches. Although a role of mangoes in skin health has long been advocated in traditional medicine, little scientific research has been conducted. We hypothesize that 85g (0.5 cups) of mango intake for 16 weeks will have minimal impact on skin health, while 250g (1.5 cups) of mango intake will produce significant benefits.

Official Title
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Influence of Mango Intake on Skin Health in Postmenopausal Women

Conditions
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Wrinkle, Skin Red

Intervention / Treatment
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* Other: 16 weeks mango intake


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Postmenopausal Fitzpatrick skin type I and II BMI 18.5 - 35.0 kg/m2 Normal blood levels in the comprehensive metabolic panel, or values slightly out of range as approved by the study physician Exclusion Criteria: Allergic to mangoes Fruit consumption of 2 or more cups per day Vegetable consumption of 3 or more cups per day for females Fruit juice consumption of more than 1 cup per day Self-reported malabsorption Currently taking regular prescription drugs i.e. statins, thyroid, anti-inflammatory drugs Had any medical or cosmetic procedures such as laser resurfacing or plastic surgery to the face within the last 6 months, including botulinum toxin, dermal fillers, collagen or other similar cosmetic procedure Autoimmune photosensitive condition or known genetic condition with a deficiency in collagen production (such as Ehler-Danlos) Smoking (current smoker, smoked within the past year, former smokers with greater than a 20 pack-year history of smoking within the past 20 years. Indications of substance or alcohol abuse Unwillingness to discontinue high antioxidant supplements during washout and interventions

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: High mango group<br>250g (1.5 cup) of mango intake per day, 4 days a week for 16 weeks | Other: 16 weeks mango intake<br>* Participants will be provided fresh frozen Ataulfo mangoes.<br>|
| Other: Low mango group<br>85g (0.5 cup) of mango intake per day, 4 days a week for 16 weeks | Other: 16 weeks mango intake<br>* Participants will be provided fresh frozen Ataulfo mangoes.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Skin Wrinkle Depth and Redness | Using a skin camera from BrighTex Bio-Photonics to measure change in skin wrinkle depth and redness within a period of 16 weeks. | 0, 8, and 16 week | 
| Skin carotenoid | Using a skin photometer (Veggie Meter) to measure change in skin carotenoid within a period of 16 weeks. | 0, 4, 8, 12, and 16 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sebum | Sebum will be collected with sebutapes from the face and stored for possible further analysis. | 0, 8, 16, weeks | 
| Plasma carotenoid | Plasma samples will be collected and stored at -80C for possible further analysis | 0, 8, 16 weeks. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Skin Health, Skin Wrinkle, Skin Redness, Carotenoid, Mango