Feasibility and Reproducibility of T1 Rho MRI in the Evaluation of Hip Cartilage

Study Overview
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Brief Summary
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Hip osteoarthritis is a frequent and invalidating disease. Early detection of cartilage modifications could provide better patient treatment. The T1rho MRI sequence allows the quantification of the cartilage signal that is correlated to modifications of the cartilage matrix, notably of the proteoglycans. The primary objective is to evaluate normal values of hip cartilage in vivo using T1rho MRI in healthy subjects and the reproducibility of the measurements. T1rho and T2 mapping sequences were acquired twice during the same session with 30 minutes interval to see if values were modified after a 30 minutes delay in a supine position. The secondary objective was to assess the correlation between T1rho and T2 values.

Official Title
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Feasibility and Reproducibility of T1 Rho MRI in the Evaluation of Hip Cartilage

Conditions
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Healthy Volunteers

Intervention / Treatment
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* Device: Hip cartilage MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: BMI <30 Accepting to participate in the study and signed the written informed consent Covered by a health insurance system Exclusion Criteria: Pregnant woman or risk of pregnancy MRI contraindication Protected adults Language barrier Previous or current hip pain

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 49 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: T1rho MRI<br>Patients included had hip cartilage MRI with acquisition of T1rho MRI sequence. | Device: Hip cartilage MRI<br>* Hip cartilage MRI<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quantification of the cartilage signal at T1rho MRI | T1rho values of total hip cartilage and for each sub-region (mean, standard deviation, histogram) | Up to one month after inclusion (Visit 1) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quantification of the cartilage signal at T1rho MRI | T1rho values of total hip cartilage and for each sub-region (mean, standard deviation, histogram) | 15 (+/- 7) days after visit 1 (Visit 2) | 
| Quantification of the cartilage signal at T2 MRI | T2 values of total hip cartilage and for each sub-region (mean, standard deviation, histogram) | Up to one month after inclusion (Visit 1) | 
| Quantification of the cartilage signal at T2 MRI | T2 values of total hip cartilage and for each sub-region (mean, standard deviation, histogram) | 15 (+/- 7) days after visit 1 (Visit 2) | 
| Presence of cartilage lesions | Morphological sequence to determine focal lesions | Up to one month after inclusion (Visit 1) | 
| Presence of cartilage lesions | Morphological sequence to determine focal lesions | 15 (+/- 7) days after visit 1 (Visit 2) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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T1rho MRI, hip, cartilage, Healthy participants