The Intestinal Function in People With Prader-Willi Syndrome

Study Overview
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Brief Summary
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The projects aim is to investigate the intestinal function of patients suffering from Prader-Willi Syndrome. The methods used are ultrasonographic measurement of the rectal diameter and gastrointestinal transit time

Detailed Description
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Prader-Willi Syndrome (PWS) is a congenital genetical disease characterized by moderate retardation, food-seeking behavior and a serious risk of developing health threatening overweight, low stature, abnormal body composition and a lack of growth- and sex-hormones. They can not live an independent life and are reliant of help from care personnel. People with PWS react abnormally to signals from their own bodies. E.g. they have a reduced sense of pain and can have a lacking urge to urination despite a full bladder. Most of the patients also have a relatively slow pulse, which can be consistent with a dysfunction in the nervous system (the parasympathetic nervous system) which also has large significance for the bladder- and bowel function. The Intestinal function in people with PWS is a sparse described subject, which has not been systematically examined in scientific context. We therefore want to examine whether the bowel function in people with PWS are different from the bowel function in healthy people. The subject is elucidated by a medical examination, a questionnaire, a registration of toilet habits, a measurement of the rectal diameter by an ultrasound scan and a measurement of the colonic transit time. The results will be compared to findings in normal healthy people. Because no normal material exists for rectal diameter measured by ultrasound, we will establish one. The result of the project will increase our knowledge of possible bowel dysfunctions such as constipation, in people with PWS and can immediately lead to improved care for and optimized treatment of the patients.

Official Title
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The Intestinal Function in People With Prader-Willi Syndrome

Conditions
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Prader-Willi Syndrome, Constipation, Incontinence

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age above 18 >14 days since last antibiotic treatment >14 days since last laxative treatment PWS confirmed genetically Exclusion Criteria: previous abdominal surgery (except appendectomy or haemorrhoidectomy patient not capable of understanding the information treatment with eltroxin or antipsychotic medication pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Prader-Willi patients<br> | |
| Control group<br>Control group for ultrasound scan | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Colonic Transit time | Measured ad modum Göteborg | 6 days | 
| Rectal diameter | measured by ultrasound scan | 1 day |