Transcriptome Study of Acute Myocardial Infarction

Study Overview
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Brief Summary
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This study aims to compare whole-blood microarray gene-expression profiling between patients with acute myocardial infarction and normal participants without cardiovascular diseases. Firstly, screening differentially genes of mRNA to perform gene ontology and pathway analysis. Secondly, predicting target genes regulated by microRNA and constructing coexpression network with mRNA. Thirdly, biological function experiment of microRNA. Finally, revealing pathogenic mechanisms associated with acute myocardial infarction.

Official Title
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Screening Pathogenic Genes Associated With Acute Myocardial Infarction and Studying Its Relevant Molecular Mechanism

Conditions
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Acute Myocardial Infarction

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: AMI patients: 20-50 years of age Symptoms of ischaemia New significant ST-segment-T wave changes in ECG and definitive diagnosis of non-ST elevation MI or ST elevation MI Cardiac troponin with at least one value above the 99th percentile upper reference limit Normal control participants: 20-50 years of age Normal ECG BMI <24kg/m2 systolic blood pressure <140mmHg diastolic blood pressure <90mmHg Total cholesterol <200mg/dl (5.18mmol/L) Triglyceride <150mg/dl (1.70mmol/L) High density lipoprotein cholesterol >=40mg/dl (1.04mmol/L) Low density lipoprotein cholesterol <130mg/dl (3.37mmol/L) Fasting blood glucose <100mg/dl (5.6mmol/L) Not taking antihypertensive or hypolipidemic or hypoglycemic drugs Exclusion Criteria: Cardiac death with symptoms suggestive of myocardial ischaemia and presumed new ischaemic ECG changes, but death occurred before cardiac biomarkers were obtained, or before cardiac biomarker values would be increased Prior myocardial infarction Percutaneous coronary intervention related MI Stent thrombosis associated with MI Coronary artery bypass grafting related MI Recurrent MI or reinfarction Myocardial injury with necrosis caused by transcatheter aortic valve implantation or mitral clip or ablation of arrhythmias Myocardial injury or infarction associated with heart failure Myocardial infarction in the intensive care unit Other diseases: previous history of ASCVD, cancer, rheumatoid arthritis, liver or kidney disease, myeloproliferative disorders, chronic inflammation, peripheral vascular disease Not available informed consent

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| AMI<br> | |
| Control<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of screening differentially expressed genes associated with acute myocardial infarction as measured by microarray |  | up to 3 years |