Anesthesia and Cancer Study: Colon Cancer

Study Overview
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Brief Summary
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This study investigates the influence of type of anesthesia on survival and recurrence rate in patients receiving colon cancer surgery. The participants will be allocated to either the TIVA group and the inhalation group.

Detailed Description
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The effect of anesthesia on cancer recurrence and survival is controversial. According to some retrospective studies and preclinical studies, total intravenous anesthesia (TIVA) is suggested to be more favorable than inhalation anesthesia regarding cancer recurrence and survival after surgery. However, there is no randomized controlled study to determine this difference in colon cancer patients.

Official Title
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The Influence of Type of Anesthesia on Mortality and Cancer Recurrence After Colon Cancer Surgery: Multi-center Prospective Randomized Controlled Study

Conditions
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Cancer of Colon, Anesthesia

Intervention / Treatment
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* Drug: Propofol
* Drug: Sevoflurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adults undergoing surgery to remove colon cancer Exclusion Criteria: pregnancy colon cancer with invasion to perineum palliative surgery history of diagnosis or surgery for other cancer emergent surgery ASA PS classification 4 and 5 refusion to participate in the study allergy to anesthetics

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: TIVA<br>propofol infusion targeting bispectral index 40-60 | Drug: Propofol<br>* propofol 1-2 mg/kg bolus injection for induction of anesthesia propofol continuous infusion for maintenance of anesthesia<br>|
| Active Comparator: inhalation (Sevoflurane)<br>sevoflurane targeting bispectral index 40-60 | Drug: Sevoflurane<br>* sevoflurane is administered for induction and maintenance of anesthesia<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| five year survival | survival rate regardless of recurrence | five years survival | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| five year recurrence free survival | survival rate without recurrence | five years after surgery | 
| 1 year recurrence free survival | survival rate without recurrence | 1 year after surgery | 
| 3 year recurrence free survival | survival rate without recurrence | 3 years after surgery | 
| 1 year survival | survival regardless of recurrence | 1 year after surgery | 
| 3 year survival | survival regardless of recurrence | 3 years after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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anesthesia, cancer, propofol, inhalational anesthetics