linjc16/ctgov huggingface dataset:
11C-Methionine PET/CT Imaging in Patients Affected by Malignant Pleural Mesothelioma (MPM)

Study Overview
=================
Brief Summary
-----------------
Prospective exploratory study specifically investigating the role of 11C-Methionine PET/CT imaging in patients affected by Malignant Pleural Mesothelioma (MPM) and candidate to pleurodesis.

Detailed Description
-----------------
This is a single-center, open-label study, lasting 36 months including an estimated period of 24 months for the enrollment and max 12 months of follow-up. All patients affected by MPM and referred to our Institution eligible for therapeutic pleurodesis and subsequent platinum- and pemetrexed-based chemotherapy will be enrolled. In all cases patients will be investigated with 11C-Methionine PET/CT and 18F-FDG PET/CT before talc pleurodesis, one week after and at the end of three cycles of chemotherapy. A minimum number of 20 patients will be considered for the analysis.

Official Title
-----------------
Diagnostic and Prognostic Role of 11C-Methionine PET/CT Imaging in Patients Affected by Malignant Pleural Mesothelioma (MPM) and Candidate to Pleurodesis

Conditions
-----------------
Mesothelioma, Malignant

Intervention / Treatment
-----------------
* Other: No intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with an histological diagnosis of MPM eligible for pleurodesis and scheduled to undergo platinum- and pemetrexed-based chemotherapy. obtained informed consent Exclusion Criteria: patients age <18 years pregnancy or breast-feeding; patients affected by other malignancies within the last 3 years;

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: No intervention|This is an observational study|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Variation of SUVmax (Maximal Standardized Uptake Value) in patients undergoing talc pleurodesis |  | Change from Baseline in SUVmax up to 1 week after talc pleurodesis. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Mesothelioma, 11C-methionine PET, talc pleurodesis
Tapentadol Versus Oxycodon - a Mechanism-based Treatment Approach in Neuropathic Pain

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to elucidate whether the additional mechanism of analgesia, i.e. reuptake inhibition of norepinephrine, of tapentadol leads to a change in different pain signs and symptoms in comparison to oxycodone.

Official Title
-----------------
Phase 4 Study of Tapentadol vs Oxycodone in Neuropathic Pain

Conditions
-----------------
Peripheral Neuropathy

Intervention / Treatment
-----------------
* Drug: tapentadol, oxycodone


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: thermal or mechanical hyperalgesia chronic neuropathic pain (NRS => 6) Exclusion Criteria: non-specific

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: oxycodone<br> | Drug: tapentadol, oxycodone<br>* tapentadol pr 100-500 mg oxycodone cr 20-120mg<br>* Other names: Palexia;|
| Active Comparator: tapentadol<br> | Drug: tapentadol, oxycodone<br>* tapentadol pr 100-500 mg oxycodone cr 20-120mg<br>* Other names: Palexia;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| QST parameters on mechanical and thermal thresholds (detailed below) | change from baseline in mechanical and thermal pain thresholds and sensitivity measured by QST | day 0 (baseline) and day 78 (10 weeks) | 
| mechanical pain threshold (MPT) |  | day 0 (baseline) and day 78 (10 weeks) | 
| mechanical pain sensitivity (MPS) |  | day 0 (baseline) and day 78 (10 weeks) | 
| dynamic mechanicl allodynia (DMA) |  | day 0 (baseline) and day 78 (10 weeks) | 
| wind-up ratio (WUR) |  | day 0 (baseline) and day 78 (10 weeks) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
QST, neuropathic pain, tapentadol pr, oxycodone
Gastroesophageal Reflux Disease in Azerbaijan

Study Overview
=================
Brief Summary
-----------------
To evaluate the prevalence of Gastroesophageal reflux disease in Azerbaijan. It is intended to evaluate the prevalence of the disease in the regions as well as the capital by cluster sampling ,ethitology and to compare the outcomes depending on the geographical location.

Detailed Description
-----------------
It is an observational, nationwide study. The GERD questionnaire (1994) requested from Mayo clinic, was received and validated. The questionnaire was translated by 3 individuals from english to azeri and back trasnlated by 3 native english speakers. Power analysis was performed. The research was presented for the approval to Ethical Committee of Azerbaijan Medical University. Prior to the actual study, a pilot study with smaller number of participants was performed and the results were evaluated. Cluster sampling methodology was provided by the statistical department of Azerbaijan Medical University. 110 employees were hired for using a survey in different regions of Azerbaijan. Written consent was obtained from every person evaluated. Statistical ananlysis was performed.

Official Title
-----------------
The Prevalence of Gastroesophageal Reflux Disease in Azerbaijan

Conditions
-----------------
Gastroesophageal Reflux Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age: 18-80 Both genders Hearburn Belching Regurgitation Exclusion Criteria: protom pomp inhibitor use antibiotic use in the last 4 weeks upper GI surgery

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The prevalence of GERD in Azerbaijan | The prevalence of GERD in Azerbaijan was 22.7% with significant female predominance (26.1% vs 15.3%; p<0.0001). GERD was defined in 17 % for ages below 35; 22.7 % for 36-55 and 38.5 % for those who are above 56 that, accordingly, indicating that GERD becomes significant as age increases (p<0.0001). Reflux was observed in 18.1% of normal weight respondents (BMI 18.6-24.9), 25.6% of overweight (BMI 25-29.9), and in 30.4% of obese (BMI>30) individuals (p=0.001). Regarding marital status, the prevalence was the lowest in the single subjects' group (17%), close to average in the married group (23.8%), and the highest (41.7%) in divorced/widowed cases (p=0.003). Stress was significantly affecting GERD distribution, affecting 59.4% of all respondents (p<0.004). | 1 year | 
| GERD questionnaire (GERD) of Mayo case 1998- 019 | Observational study | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
gastoesophageal reflux disease, prevalence, Azerbaijan
Partnering With Media and Vaccination Program to Improve Infant and Young Child Feeding

Study Overview
=================
Brief Summary
-----------------
Infant and young child feeding (IYCF) is a key determinant of under-nutrition and overweight in young children. In Mexico, breastfeeding extends well into the second half of infancy, but animal-source foods, cereals, and legumes are not regularly provided to the child by 9 mo. This study evaluates whether knowledge and practices about dietary diversity and food consistency can be improved using a two-component intervention strategy in semi-urban communities in Mexico. The two components will deliver appropriate complementary feeding messages using: (a) nurses during the 1st National Vaccination Week (NVW); and (b) radio messages and interviews. The intervention is evaluated using a cluster randomized design in small semi-urban communities in two states in Mexico with pre- and post-test questionnaires designed to assess changes in feeding behaviors.

Official Title
-----------------
Partnering With Media and Vaccination Program to Improve Infant and Young Child Feeding

Conditions
-----------------
Infant and Young Child Feeding

Intervention / Treatment
-----------------
* Behavioral: Appropriate complementary feeding messages


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Mothers with healthy children between 6 and 24 mo Exclusion Criteria: None

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: National Vaccine Program Plus Radio<br>Appropriate complementary feeding messages delivered using: (a) nurses during the 1st National Vaccination Week (NVW); and (b) radio. | Behavioral: Appropriate complementary feeding messages<br>* Messages delivered through National Vaccine Program and radio<br>|
| No Intervention: Comparison (no intervention)<br>No complementary feeding messages delivered. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Provision of flesh-food or vitamin A-rich food | Mothers provide at least one flesh-food (i.e., beef, chicken, fish, liver) or one vitamin A-rich fruit or vegetable in the previous day | Change from baseline to 5 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Provision of solid, semi-solid, or soft foods (i.e., not runny soups or broths) Provision of solid, semi-solid, or soft foods | Mothers provide solid, semi-solid, or soft foods (i.e., not runny soups or broths) at least 1 meal/d (6-12 mo) or 2 meals/d (12-24 mo) | Change from baseline to 5 months |
Reducing Range of Motion Deficits Post Radial Fracture

Study Overview
=================
Brief Summary
-----------------
This a randomized controlled study to test the hypothesis that patients who perform in-cast exercises will have superior range of motion immediately post-cast removal, without a concomitant increase in complication rate when compared with a control group who receives standard post cast care which does not include the intervention exercises.

Official Title
-----------------
Reducing Range of Motion Deficits With In-cast Exercises: A Randomized Controlled Trial

Conditions
-----------------
Radius Fractures

Intervention / Treatment
-----------------
* Other: Exercises


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patient experienced distal radial fracture patient is over 18 years of age patient can follow instructions and comply with protocol fracture is managed non-operatively Exclusion Criteria: bilateral wrist fractures previous fracture to the affected wrist previous range of motion limitations to the affected wrist involvement of other upper extremity structures (i.e. shoulder)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Exercise<br>This group will receive instructions on specific exercises to perform after randomization. | Other: Exercises<br>* A specific set of standardized exercises will be taught to patients who are randomized to the intervention group. They will be instructed to do these exercises daily while in-cast. They will have an exercise log to track adherence.<br>|
| No Intervention: Standard Care<br>This group will receive standard care | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in range of motion |  | 6 weeks, 6 months, 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complications | The number and type of complications will be collected and compared between groups | 6 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
fracture, radius, adult, range of motion
A Registry of Peripartum Cardiomyopathy in Turkey

Study Overview
=================
Brief Summary
-----------------
Peripartum cardiomyopathy (PPCM) is a global disease with significant morbidity and mortality of young women. Its' etiology, epidemiology and treatment is not yet well described. This will be a retrospective, national, multicenter observational study, conducted in Turkey. It is expected that approximately 50 women with PPCM will be recorded.

Detailed Description
-----------------
Peripartum cardiomyopathy (PPCM) is a global disease with significant morbidity and mortality of young women. Its' etiology, epidemiology and treatment is not yet well described. This will be a retrospective, national, multicenter observational study, conducted in centres in Turkey. It is expected that approximately 50 women with PPCM will be recorded. The objectives of the study are: To define the clinical status and clinical characteristics of PPCM in Turkey To define the outcome of PPCM (short and long term) To define the demographical and possible etiological factors To define prognostic factors

Official Title
-----------------
Clinical A Nation-wide Registry of Peripartum Cardiomyopathy: Clinical Status in Turkey

Conditions
-----------------
Peripartum Cardiomyopathy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient above 18 years of age Unexplained Heart Failure symptoms developed towards the end of pregnancy or in the first 6 months of postpartum period Ejection fraction less than 45% documented with echocardiography Exclusion Criteria: Patients with any other known cardiac pathology

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pregnancy outcome | mortality of the mother | 5 months after delivery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Peripartum Cardiomyopathy, Heart Failure
Fast Stepping in Stroke Patients for Fall Prediction and Prevention:Control Mechanisms and Clinical Implications

Study Overview
=================
Brief Summary
-----------------
The purpose of this study was to compare the balance strategy, as well as center of pressure (COP) trajectory and parameters between healthy adults and patients with hemiplegia in response to slow- and fast-speed waist- pulling perturbations in forward, left, right, and backward directions.

Detailed Description
-----------------
The ability to quickly respond to external perturbations is an important capacity of stroke patients to maintain dynamic balance in activities of daily living. The purpose of this study was to compare the balance strategy, as well as center of pressure (COP) trajectory and parameters between healthy adults and patients with hemiplegia in response to slow- and fast-speed waist- pulling perturbations in forward, left, right, and backward directions.

Official Title
-----------------
Fast Stepping in Stroke Patients for Fall Prediction and Prevention:Control Mechanisms and Clinical Implications

Conditions
-----------------
Stroke

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy adults Age ang Sex are correspond with the stroke subjects(between 40 and 75 years old) being willing to accept one-year follow-up examination being willing to sign an informed consent approved by the Human Subjects Committee of the National Taiwan University Hospital Stroke patients between 40 and 75 years old stroke confirmed by ICD-10-CM (including I60, I61, I62, I63, I67, and I69) first stroke with single side hemiplegia and received acute treatment at NTUH being willing to sign an informed consent approved by the Human Subjects Committee of the National Taiwan University Hospital able to step forward, laterally and backward independently without assistive device Excursion criteria: Healthy adults - having other neurological diseases, or moderate to severe neuromuscular or musculoskeletal disorders, or disorders from systematic diseases those would influence the belance or motor ability Stroke patients having unstable vital sign, unconsciousness, or obvious cognitive, perception, and language impairment, and couldn't communicate with the experimenters having other neurological diseases, or moderate to severe neuromuscular or musculoskeletal or cardiovascular disorders, or disorders from systematic diseases other than stroke

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hemiplegia, Waist pulling perturbation, Reactive balance strategy, Trajectory of center of pressure, Parameters of center of pressure
High-resolution Esophageal Manometry

Study Overview
=================
Brief Summary
-----------------
EA is one of the most frequent birth defects, with an incidence of 1 in 3000 live births1. Until the 1950s, these patients had 100% mortality; nowadays, the survival rate is greater than 90%, and only those with associated severe malformations die1-5. Type C EA (atresia of the esophageal proximal segment with tracheoesophageal fistula between the trachea and the distal segment) is the most common variant, since it is present in 85% of the cases6-8. There is evidence that the esophageal motor disorder present in these children is secondary to a congenital neuromuscular disorder and a postoperative disorder9-14. Patients that survive the operation have greater risk of developing gastroesophageal reflux disease (GERD), caused by anomalies in the esophageal motility and its resulting delay in the evacuation of acid of the esophageal lumen. There was a hypothesis that suggested that motility alteration could contribute to dysphagia and to the high prevalence of gastroesophageal reflux in these patients15-18. Also, there were reports of a greater incidence of severe esophagitis with requirement of fundoplication, which shows a larger failure rate17-18. Esophageal dysmotility has been proved in children with EA through performance of conventional perfusion manometry. Lemoine C et al described three motility alteration patterns with HRM in children with repaired EA. Said study allowed a more precise knowledge of segmental esophageal motility19. Currently, there are no reports exclusively made about teenagers with repaired EA that describe segmental esophageal motility with HRM.

Official Title
-----------------
High-resolution Esophageal Manometry in Teenagers With Esophageal Atresia

Conditions
-----------------
Esophageal Atresia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: teenagers of more than 12 years old, with repaired EA, orally fed during the last 6 months, with no history of esophageal blockage or dilations, who underwent a HREM Exclusion Criteria: patients under 12 years old

Ages Eligible for Study
-----------------
Minimum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patterns of High Resolution Manometry in teenagers with esophageal atresia | Number of patients with patterns of complete aperistalsis, pressurization and distal esophageal contraction in High Resolution Manometry | one day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
high-resolution manometry, esophageal atresia, teenagers