New Echocardiographic Parameters for Assessment of Longitudinal Left Ventricular Function

Study Overview
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Brief Summary
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Assessment of left ventricular systolic function is the most frequent indication for routine echocardiography. Qualitative eyeball method and biplane modified Simpson's rule, both measuring radial ventricular function, are the currently recommended methods to meet this challenge. Due to the complexity of the myocardial architecture, global left ventricular function also has longitudinal and torsional components. The aim of this study is to evaluate new echocardiographic parameters for longitudinal left ventricular function. A special focus is set on strain imaging by speckle tracking, which is a relatively new technique. Patients with different cardiac pathologies (e. g. dilated cardiomyopathy, coronary artery disease, diastolic dysfunction) will be included and compared to healthy individuals.

Official Title
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New Echocardiographic Parameters for Assessment of Longitudinal Left Ventricular Function

Conditions
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Cardiovascular Pathology

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: persons of 18 years and older who receive a transthoracic echocardiography at our department written consent Exclusion Criteria: permanent pacemaker rhythm moderate/severe valvular heart disease

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control<br>Healthy individuals without structural heart disease | |
| CAD<br>Patients with coronary artery disease | |
| DCM<br>Participants with dilated cardiomyopathy | |
| HNCM<br>Patients with hypertrophic non-obstructive cardiomyopathy | |
| HOCM<br>Patients with hypertrophic obstructive cardiomyopathy | |
| RCM<br>Patients with restrictive cardiomyopathy | |
| Amyloidosis<br>Patients with cardiac manifestation of amyloidosis | |
| HFPEF<br>Patients with heart failure with preserved ejection fraction (diastolic heart failure) | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| left ventricular longitudinal systolic strain (LV-LSS) in all patients | left ventricular longitudinal systolic strain (LV-LSS) is measured in all patients by speckle tracking strain imaging | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mitral annular plane systolic excursion (MAPSE) in all patients | MAPSE is measured by M-Mode echocardiography | 2 years | 
| mitral annular systolic velocity (MASV) in all patients | MASV is derived from tissue doppler | 2 years | 
| diastolic left ventricular function in all patients | Diastolic function is assesed by mitral inflow, mitral annulus velocity, pulmonary vein flow and velocity of flow progression. | 2 years | 
| pulmonary artery systolic pressure (PASP) in all patients | PASP is derived from Tricuspid valve regurgitation velocity | 2 years | 
| left ventricular ejection fraction (LVEF) in all patients | EF is measured by modified Simpson's rule (biplane) | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Echocardiography, Strain imaging, Ventricular Dysfunction, Cardiomyopathy, Longitudinal left ventricular function