Relationship Between Chronic Periodontitis and Vitamin D and Calcium in Men

Study Overview
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Brief Summary
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Objective: The objective was to evaluate whether serum vitamin D and calcium concentrations are associated with chronic periodontitis in Syrian men Methods: This study designed as Matched Case-Control Study.200 males will be enrolled in this study and will be divided into two groups. First group consist of 100 patients suffering from chronic periodontitis and no systemic diseases. Second group consist of 100 healthy volunteers. Serum vitamin D and calcium concentrations will be tested. Periodontal indexes include probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) will be taken. Data will be collected and analyzed.

Detailed Description
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Periodontal disease including chronic periodontitis results from interaction between pathogens and the host inﬂammatory response. This interaction triggers a complex process of inﬂammatory events, which in turn promote connective tissue destruction and alveolar bone remodeling. Periodontitis is described as a multifactorial irreversible and cumulative condition, initiated and propagated by bacteria and host factors. Vitamin D and calcium are fundamental for bone mineralization and for the prevention of osteoporosis Severe vitamin D deficiency lead to mineralization defects but chronically low intake of vitamin D and calcium leads to bade calcium balance and bone loss, and it is reasonable to expect this effect to occur in alveolar bone as it does in other bones of the body. A study has showed a positive association between low bone mass or osteoporosis and alveolar bone loss and tooth loss. Vitamin D serum concentrations might affect periodontal disease both through an effect on bone mineral density (BMD) and through immunomodulatory effects. Vitamin D is well established as being essential for bone growth and preservation. A potential anti-inflammatory effect of vitamin D is supported by an increasing amount of literature. The active metabolite of 25-hydroxyvitamin D, 1,25dihydroxyvitamin D, has been found to inhibit cytokine production and cell proliferation. Low serum levels of vitamin D have been linked with a loss of periodontal attachment. Data from over 11,000 subjects were analyzed for serum vitamin D levels and attachment loss. In subjects less than 50 years of age, there was no signiﬁcant association reported between vitamin D levels and attachment loss. In patients 50 years or older, serum vitamin D levels were inversely associated with attachment loss for men and women. It was concluded that the increased risk for periodontal disease might be attributable to low levels of vitamin D, which would reduce bone mineral density, or to an immunomodulatory eﬀect. In van der Putten et al study, based on the literature available to date, the association of vitamin D, and calcium deﬁciencies with periodontal disease in elderly people is essentially still unknown and not well researched. To produce conclusive evidence on the subject of this systematic literature review, longitudinal cohort studies and follow-up randomized controlled trials are needed The aim of this study is to explore chronic periodontitis status and serum vitamin D and calcium concentrations in Syrian males and compare these figures with matched healthy volunteers with no periodontitis.

Official Title
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Relationship Between Chronic Periodontitis and Vitamin D and Calcium in Men

Conditions
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Chronic Periodontitis

Participation Criteria
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Eligibility Criteria
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First group (Chronic Periodontitis) inclusion criteria: Male patients Patients are suffering from chronic periodontitis Patients do no have systemic diseases Patients should have 20 teeth at least 30 year old at least Second group (Healthy Volunteers) inclusion criteria: Male individuals With no systemic diseases or periodontitis 30 year old at least 20 teeth at least for each participant

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Chronic Periodontitis<br>Male patients Patients are suffering from chronic periodontitis Patients do not have any systemic diseases Subjects should have 20 teeth at least Age: 30 years or greater | |
| Healthy Volunteers<br>Males Healthy with no systemic diseases or periodontitis 30 years old at least 20 teeth are present at least | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum Vitamin D concentration |  | One time assessment, within 24 hours before delivering any treatment | 
| Serum Calcium concentration |  | One time assessment, within 24 hours before delivering any treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pocket Depth |  | One time assessment once sample recruitment has completed and within 24 hours before delivering any treatment. | 
| Bleeding on Probing |  | One time assessment once sample recruitment has completed and within 24 hours before delivering any treatment. | 
| Clinical Attachment Loss (CAL) |  | One time assessment once sample recruitment has completed and within 24 hours before delivering any treatment. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Chronic Periodontitis, Vitamin D concentration, Calcium concentration