Biological Age Applied at Ubberup

Study Overview
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Brief Summary
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In a previous study the investigators have developed a novel biological age model. Assessing biological age is the assessment of the present health status and functional capacity/physiological reserve of that person in comparison with people of the same age and sex. The aim of this study is to investigate the utility and validity of this novel biological age model designed for health promotion in real world conditions.

Detailed Description
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Study design: This is a longitudinal study, where biological age assessment is conducted in the first and final week of an 11-14 week lifestyle intervention course. These courses take place at a Danish folk high school (Ubberup), which is specialized in performing intensive lifestyle interventions targeting a 10% weight loss. The intention is to include 80 adult men and women. Data collection: This will take place at the facilities at Ubberup folk high school, participants being overnight fasted and without having exercised for the previous 24 hours. All analysis will be performed in investigators lab (Xlab) at the Department of Biomedical Sciences, Copenhagen University. When all samples are analysed Biological age will be calculated for each particpant.

Official Title
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Evaluation and Validation of Biological Age as Health Technology

Conditions
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Healthy Aging, Lifestyle Risk Reduction

Intervention / Treatment
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* Behavioral: Lifestyle intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participation in a long course at Ubberup folk high school (12-15 weeks) Age between 18-65 years Exclusion Criteria: Previous or current cardiovascular disease Pregnancy Conditions that prevents from performing a cycle and/or strength tests

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Winter course<br>The recruited particpants attending the winter course | Behavioral: Lifestyle intervention<br>* The 14 week courses takes place at a Danish folk high school (Ubberup), specialized in lifestyle interventions targeting a 10% weight loss. Adult individuals with obesity sign up for the course. They stay at the School for the whole course period and the total cost amounts to 300-400 Euros per week plus loss of income.<br>|
| Fall course<br>The recruited particpants attending the winter course | Behavioral: Lifestyle intervention<br>* The 14 week courses takes place at a Danish folk high school (Ubberup), specialized in lifestyle interventions targeting a 10% weight loss. Adult individuals with obesity sign up for the course. They stay at the School for the whole course period and the total cost amounts to 300-400 Euros per week plus loss of income.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in biological age | a composite score predicting risk of lifestyle related diseases | week1 and week 14 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in cardiorespiratory capacity | VO2max maximal oxygen consumption (ml/min/kg | week 1 and week 14 | 
| Change in strength | Hand grip, isometric quadriceps and biceps strength (Nm) | week 1 and week 14 | 
| Change in Sit to Stand test | Rise and sit from a chair as many times as possible during 1 minute (number og rises) | week 1 and week 14 | 
| Change in Central obesity | Waist to hip ratio is measured by dividing waist circumference with hip circumference in cm. | week 1 and week 14 | 
| Change in body weight | measured in kilograms | week 1 and week 14 | 
| Change in body composition | BMI (kg/m2) is calculated | week 1 and week 14 | 
| Change in fat mass | fat mass(g) is assessed by bioimpedance | week 1 and week 14 | 
| Change in fat percentage | Fat%, is assessed by bioimpedance | week 1 and week 14 | 
| Change in muscle mass | muscle mass(g) is assessed by bioimpedance | week 1 and week 14 | 
| Change in lipid profile | HighDensityLipoprotein (mmol/L), LowDensityLipoprofile (mmol/L), TriGlycerides (mmol/L), FreeFattyAcids (mmol/L) and Glycerol (mmol/L) is measured in a blood sample. | week 1 and week 14 | 
| Change in Inflammatory profile | C-reactive protein mg/L, soluble urokinase plasminogen activating receptor ng/ml, InterLeukin 6 and 8 (pg/mL), tumor necrosis factor (pg/mL), Leptin and Adiponectin (ng/ml) is analysed from blood samples | week 1 and week 14 | 
| Change in Blood glucose | HbA1c and fasting glucose (mmol/L) measured from blood sample | week 1 and week 14 | 
| Change in Respirometry | forced vital capacity and forced expiratory volume at one second(L) | week 1 and week 14 | 
| Change in Blood Pressure | Systolic and Diastolic blood pressure (mmHg) | week 1 and week 14 | 
| Change in Advanced glycation endproducts | Levels of glycated protein and lipids as a result of exposure of excess sugars advanced glycation endproducts (AGE) measured in the skin | week 1 and week 14 | 
| Change in Hormones | Insulin | Week 1 and week 14 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Individualised Health, Prediction, Risk Assessment