Proteomic Analysis in Sera From Patients With Erosive Hand Osteoarthritis

Study Overview
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Brief Summary
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Hand osteoarthritis is a common phenotype of osteoarthritis which affects about 70 % of the elderly population. Usually considered as a minor illness, it nevertheless leads to an important functional impairment. The mechanism of this disease is still poorly known. Furthermore there are 2 different subtypes : erosive and non erosive hand osteoarthritis from which mechanisms may differ. Methods: This is a cross-sectional study recruiting patients with hand osteoarthritis addressed in consultation of rheumatology and plastic surgery in Rouen University Hospital. Two groups of patients will be studied: 20 patients with non erosive subtype of hand osteoarthritis and 20 patients with erosive subtype of hand osteoarthritis. A clinical evaluation of hand osteoarthritis will be performed. Blood sample for proteomic analysis will be taken. Hand MRI and Bone Mineral Analyser will be performed.

Official Title
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Proteomic Analysis in Sera From Patients With Erosive Hand Osteoarthritis

Conditions
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Erosive Hand Osteoarthritis

Intervention / Treatment
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* Procedure: Biological sampling
* Device: Radiographic evaluation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Female gender Less than 70 years old Diagnosis of hand osteoarthritis according to ACR criteria ACR after exclusion of thumb base osteoarthritis: Hand pain, aching or stiffness most of the days during the preceding month Hard tissue enlargement of at least two of 8 selected joints * Hard tissue enlargement of at least two distal interphalangeal joint Swelling of fewer than three metacarpophalangeal joint Deformity of at least one of 10 selected joints * Patients have to fulfil criteria 1, 2 AND 3 + 4 OR 5 * the 8 selected joints are the second and third distal interphalangeal joint and the second and third proximal interphalangeal of both hands Then confirm by experts' committee Exclusively symptomatic treatment For women of child-bearing age, use of an effective contraceptive method French spoken and read Exclusion Criteria: Male gender More than 70 years old Hemochromatosis Inflammatory arthritis Cristal induced arthritis Active diseases such as infection or cancer Use of DMARDs Pregnant or breast-feeding woman

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patient with hand osteoarthritis<br>Biological sampling and Radiographic evaluation of patient with erosive and non erosive hand osteoarthritis | Procedure: Biological sampling<br>* Biological sampling to identify by label-free proteomic analysis of a combination of serum biomarkers in patients with Erosive and non erosive hand Osteoarthritis<br>Device: Radiographic evaluation<br>* Radiographic assessments using Bone Mineral Analyser and Hand MRI will be done in patients with Erosive and non erosive hand Osteoarthritis<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quantification by label-free proteomic analysis of the serum of patients affected by hand osteoarthritis | Assessments done using biological sampling | day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Erosion in patients affected by hand osteoarthritis | Number of Erosion in patients affected by hand osteoarthritis is evaluated using Bone Mineral Analyser | Day 1 |