The Noninvasive Ventilation to COVID-19 Patients

Study Overview
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Brief Summary
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Noninvasive ventilation(NIV) is an important treatment to the respiratory failure patients.The severe Corona Virus Disease-19(COVID-19) patients are incline to respiratory failure.The NIV may reduce the intubtion rate.This research was taken to investigate the factor to the success of the noninvasive ventilation to the COVID-19 patients with respiratory failure.

Detailed Description
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Noninvasive ventilation(NIV) is an important treatment to the respiratory failure patients.The severe Corona Virus Disease-19(COVID-19) patients are incline to respiratory failure.The NIV may reduce the intubtion rate.This research was taken to investigate the factor to the success of the noninvasive ventilation to the COVID-19 patients with respiratory failure.We wish to raise the success rate to COVID-19 patients with respiratory failure.More critically ill COVID-19 patients could avoid the intubtion.

Official Title
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The Noninvasive Ventilation to COVID-19 Patients With Respiratory Failure

Conditions
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Noninvavie Ventilation to Patients With COVID-19

Intervention / Treatment
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* Device: noninvasive ventilation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Shortness of breath, RR>30 times per minute; At room air, SpO2 lower than 93%; The partial pressure of Arterial blood oxygen (PaO2)/the fraction of inspired oxygen (FiO2) ≤ 300mmHg; CT（computed tomography） chest imaging shows that lung damage develops significantly within 24 to 48 hours. Exclusion Criteria: Severe cardiovascular disease, respiratory arrest, cardiovascular instability (hypotension, arrhythmias, myocardial infarction), change in mental status or patients who were uncooperative, high risk of aspiration, viscous or copious secretions, recent facial or gastroesophageal surgery, craniofacial trauma, 8)fixed nasopharyngeal abnormalities, 9）burns, 10) extreme obesity.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COVID-19 patients need noninvasive ventilation<br> | Device: noninvasive ventilation<br>* noninvasive ventilation to support the COVID-19 patients with respiratory failure<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| success rate | the sucess rate of the noninvasive ventilation | 4 month | 
| the intubtion rate | the intubtion rate of the COVID-19 patients | 4 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| blood lymphocyte | blood lymphocyte of the COVID-19 patients | 4month | 
| B-type natriuretic peptide | blood B-type natriuretic peptide of the COVID-19 patients | 4 month | 
| Procalcitonin | blood procalcitonin of the COVID-19 patients | 4 month | 
| Oxygen Saturation | Oxygen Saturation of the COVID-19 patients | 4 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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noninvavie ventilation, COVID-19, respiratory failure