Investigation of How Morning Nutrition Influences Cognitive Performance

Study Overview
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Brief Summary
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This project will assess the effects of the macro-nutrient make-up of morning food intake on cognitive performance using visual analog scale (VAS) measures, behavioral tests, and advanced high-density electrophysiological techniques (256-channel recordings). Two Isocaloric cereal products will be tested and compared to determine if measures of cognitive performance as well as satiety will change after consumption.

Official Title
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Investigation of How Morning Nutrition Influences Cognitive Performance

Conditions
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Cognitive Performance

Intervention / Treatment
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* Other: Cereal with B glucan
* Other: Cereal without B glucan


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy and taking no regular medications other than birth control or hormone replacement therapy Willing to use an effective contraceptive during the study, if sexually active and capable of bearing children Willing and able to sign informed consent Normal or corrected-to-normal vision Normal or corrected-to-normal hearing No history of neurological or psychiatric illness, including major depressive disorder and attention deficit disorder No history of substance, nicotine or alcohol dependence BMI below 35 Exclusion Criteria: Women who are pregnant or nursing Gain or loss of > 4kg in the last 3 months. Currently taking supplements or medications for weight loss Currently taking medications for neurological or psychiatric illness Diabetes mellitus (fasting glucose >126 mg/dL) or history of diabetes Dietary restraint on the Three Factor Eating Questionnaire score greater than or equal to 14 Allergy to any of the foods used for the test breakfasts (oats or milk) History of GI disorders or GI surgical procedures for weight loss History of eating disorders Daily consumption of more than 400 mg of caffeine

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 44 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cereal 1<br>A cereal high in viscous dietary fiber B glucan | Other: Cereal with B glucan<br>* A cereal high in viscous dietary fiber B glucan<br>|
| Active Comparator: Cereal 2<br>A cereal without B glucan | Other: Cereal without B glucan<br>* Cereal without B glucan<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cognitive performance | cognitive performance using psychometric scales | 0-4 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| subjective measures of hunger | subjective measures of hunger using Visual Analog Scale | 0-4 hours |