Interval Versus Continuous Training on Functional Capacity and Quality of Life in Patients With Coronary Artery Disease

Study Overview
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Brief Summary
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Exercise therapy increase functional capacity improving the morbidity and mortality of patients with cardiovascular disease. Moderate continuous training is the best established training modality for this patients. However, a body of evidence has begun to emerge demonstrating that high intensity interval training obtained better results in terms of morbidity and mortality. The purpose of this randomized clinical trial was to determine the effect of two types of exercise training: moderate continuous training vs high interval training on functional capacity and quality of life as well as verify the safety in its application. We included 72 patients with coronary artery disease by assigning one of the training modality for 8 weeks. We analyzed cyclo-ergo-spirometry data, aspect related to quality of life as well as a record of adverse events.

Official Title
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Interval Versus Continuous Exercise Training on Functional Capacity and Quality of Life in Patients With Coronary Artery Disease: a Randomized Clinical Trial

Conditions
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Coronary Heart Disease

Intervention / Treatment
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* Other: Moderate continuous exercise training
* Other: Interval exercise training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Coronary heart Disease, with functional class II-III according to New York Heart Association classification system. At least 4 weeks from acute cardiac event, percutaneous or surgery revascularization. Optimized medical treatment in adequate doses ( betablockers, ACE inhibitors, ARA II, statins and antiplatelet drugs) Age > 18 years old. Willing to participate and sign an informed consent form Exclusion Criteria: Residual ischemia waiting for revascularization. Any cardiac event for the last 4 weeks Abnormal Ergometry with hemodynamic or clinically significant arrhythmias during the procedure. History of severe ventricular arrhythmia Uncontrolled glycaemia or blood pressure Moderate to severe Chronic Pulmonary Obstructive Disease Osteomuscular and/or mental disorder that hampers an adequate adherence to the intervention program Other vascular diseases: rheumatologic/ autoimmune disorders, thrombopathies, hemophilia. Active oncologic disease. Treatment with corticosteroids.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Moderate continuous exercise training<br>Moderate intensity continuous exercise training | Other: Moderate continuous exercise training<br> <br> |
| Experimental: Interval exercise training<br>High intensity interval exercise training | Other: Interval exercise training<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Impact on functional capacity | Basal and peak oxygen consumption values will be measured. | 2 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| quality of life | Quality of life will be compared between the two arms with one generic questionnaire (SF-36) and one ischemic heart disease specific questionnaire (MacNew) | 2 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Safety, Coronary Heart Disease, Interval exercise training, Continuous exercise training, Quality of life