Determination of Risk Factors and Mortality for Pediatric Chronic Critical Illness in Turkey

Study Overview
=================
Brief Summary
-----------------
It is predicted that the number of Pediatric Chronic Critical Illness increases similar to adult all over the world. The prevalence of Pediatric Chronic Critical Illness in Turkey is unknown. The investigators aimed to evaluate the etiology, comorbid conditions, demographic data, prevalence, mortality and costs of these patient in intensive care units in Turkey. In this multi-centered study, The investigators will retrospectively review the last 3 year of patients receiving treatment at the Intensive Care Unit.

Detailed Description
-----------------
Patients receiving acute critical cause of ICU in the Intensive Care Unit (ICU) may be hospitalized for longer periods of time due to accompanying diseases or iatrogenic causes. This disease is called Chronic Critical Illness (CCI). CCI is associated with prolonged acute mechanical ventilation, but there is no definition in the literature for newborns. Pediatric CCI is estimated to be similar to adults. In the United States, the number of CCI is around 250,000, which is estimated to have doubled in the last 10 years. 50% of patients die in one year and much less than 12% recover. The estimated annual cost for the CCI in the United States is over $ 20 billion. The prevalence of Pediatric CCI in Turkey is unknown. In this study, it was aimed to investigate risk factors, mortality and cost of children with chronic critically ill and newborn patients in intensive care units in Turkey.

Official Title
-----------------
Determination of Risk Factors and Mortality for Pediatric Chronic Critical Illnes in Turkey: Multicenter Study

Conditions
-----------------
Critical Illness

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Chronic Critical IIlness The patients who are younger than 18 years old and staying in ICU for at least 14 days. (The patients who is newborn and stay in the intensive care unit for 30 days in addition to prematurity). At least one of the additional criteria; Prolonged acute mechanical ventilation Tracheostomy Sepsis Severe wound (burn) or trauma Encephalopathy (Post resuscitation syndrome, Asphyxia, Intra-cranial hemorrhage, Metabolic disease, etc.) Traumatic brain injury Status epilepticus Post operative (Cardiac and noncardiac) Neuromuscular disease (Spinal Muscular Dystrophy, Cerebral Palsy, Muscular Dystrophy) Exclusion Criteria: Patients with a disease other than a chronic critical disease Patients older than 18 years

Ages Eligible for Study
-----------------
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Critical care unit mortality | The mortality change rates in the 30th Day, 90th Day, 180th Day, 365th Day | 30 Day, 90 Day, 180 Day, 365 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Critical care unit costs for infant patients | Cost of patients staying in intensive care unit | Duration of intensive care unit stay (From 14 day to 1 years after hospitalization) | 
| Critical care unit costs for premature newborn | Cost of patients staying in intensive care unit | Duration of intensive care unit stay (From 1 month to 1 year after hospitalization) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Prolonged acute mechanical ventilation