linjc16/ctgov huggingface dataset:
Pilot Study in a Company in Maine-et-Loire to Evaluate the Feasibility, Acceptability, and Impact on the Participation Rate of Awareness of Colorectal Cancer Screening by Occupational Health Teams

Study Overview
=================
Brief Summary
-----------------
The main objective of this pilot study is to implement an awareness campaign for colorectal cancer screening in the workplace, in partnership with the staff of the occupational health service of one of the largest companies in Maine-Loire , and to evaluate the impact of this action on the participation rate of colorectal cancer screening among employees.

Official Title
-----------------
Pilot Study in a Company in Maine-et-Loire to Evaluate the Feasibility, Acceptability, and Impact on the Participation Rate of Awareness of Colorectal Cancer Screening by Occupational Health Teams

Conditions
-----------------
Colorectal Cancer

Intervention / Treatment
-----------------
* Other: awareness campaign


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The study population is made up of the employees of the CHU d'Angers included in the target population of organized colorectal cancer screening in the Maine-et-Loire so employees aged 50 and over. Exclusion Criteria: The criteria for non-inclusion are those of organized screening for colorectal cancer taking into account the active population: Age <50 years and> 67 years Personal or family history of polyps or colorectal cancer Personal history of intestinal disease already undergoing colonoscopy surveillance (chronic inflammatory bowel disease, HNPCC syndrome, familial adenomatous polyposis) Known genetic disease with risk of developing colorectal cancer.

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 66 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: awareness campaign|awareness campaign for colorectal cancer screening in the workplace|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| variation of the rate of participation in colorectal cancer screening | effective variation (after versus prior to awareness raising) of the overall rate of participation in colorectal cancer screening among employees of the company after 2 years. | 2 years |
Comparison of Two Tests in the Assessment of the Accuracy of Esophageal Pressure Variations Measurement During Mechanical Ventilation

Study Overview
=================
Brief Summary
-----------------
Esophageal pressure measurement, obtained with the use of an esophageal balloon catheter, is fundamental to assess mechanical characteristics of the respiratory system during mechanical ventilation. The correct positioning of the catheter (usually at the medium third of the esophagus) is crucial for an accurate measurement of esophageal pressure. Usually the correct positioning of the catheter is verified with an occlusion test (If the patient is breathing spontaneously) or with thoraco-abdominal compressions (if the patient is sedated and paralyzed). Aim of this study is to compare the accuracy of these two methods at different PEEP and esophageal catheter positions.

Conditions
-----------------
Esophageal Pressure Measurement

Intervention / Treatment
-----------------
* Other: Occlusion test
* Other: Thoraco-abdominal compressions


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Mechanical ventilation for clinical purposes Exclusion Criteria: Hemodynamic instability Esophageal diseases Refusal of the patient

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Postsurgical patients sedated and paralized<br>Patients admitted to ICU after surgery, treated with mechanical ventilation, sedated and paralized | Other: Thoraco-abdominal compressions<br>* Thoraco-abdominal compressions to assess the correct positioning of esophageal balloon catheter when the patient is sedated and paralyzed.<br>|
| Postsurgical patients intubated and breathing spontaneously<br> | Other: Occlusion test<br>* Occlusion test to assess the correct positioning of esophageal balloon catheter when the patient is breathing spontaneously.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correct esophageal catheter balloon position |  | 10 minutes after the start of the study | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Esophageal pressure, Mechanical ventilation
Drug Use Investigation for LAMICTAL

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to grasp actual status of usage of lamotrigine tablet and to collect information for using lamotrigine tablet effectively and safely as well as to grasp onset status of adverse events in pediatric subjects, geriatric subjects, pregnant women, subjects with poor renal and hepatic functions.

Official Title
-----------------
Drug Use Investigation for LAMICTAL

Conditions
-----------------
Epilepsy

Intervention / Treatment
-----------------
* Drug: Lamotrigine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subjects with epilepsy having the following seizure types. Partial seizures (including secondary generalized seizures) Tonic-clonic seizures Generalized seizures of Lennox-Gastaut syndrome Exclusion Criteria: - None
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Subjects prescribed lamotrigine tablet<br>Subjects with epilepsy prescribed lamotrigine tablet during study period | Drug: Lamotrigine<br>* Administered according to the prescribing information in the locally approved label by the authorities<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The number of adverse events in Japanese subjects with epilepsy treated with lamotrigine tablet |  | 6 months |
Misopristol Versus Pitocin for Second Trimester Abortion

Study Overview
=================
Brief Summary
-----------------
Second trimester abortion can be done surgically or medically. Medical abortion with mifepristone and misopristol is one of the common protocol, but misopristol have high rate side effect. The investigators recent study proved the efficacy of pitocin after mifepristone in second trimester abortion with minimal side effects. Working hypothesis and aims: To compare misopristol and pitocin after mifepristone preparation in second trimester in seccess rate, interval to abortion, side effects and patient satisfaction.

Official Title
-----------------
Comparison Between Misopristol and Pitocin After Mifepristone Preparation for Second Trimeter Abortion

Conditions
-----------------
Abortion, Missed

Intervention / Treatment
-----------------
* Drug: mifepristone and misopristol
* Drug: mifepristone and oxytocin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: midtrimester late abortion midtrimester induced abortion Exclusion Criteria: placenta previa infected abortion rupture of membranes s/p cesarean section *2 or more

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: pitocin<br>high dose pitocin drip 48 hours after mifepristone preparation. | Drug: mifepristone and oxytocin<br>* 200 mg mifepristone followed 48 hours with high dose oxytocin drip (9 unit per hour)<br>|
| Active Comparator: misopristol<br>vaginal and oral misopristol 48 hours after mifepristone preparation. | Drug: mifepristone and misopristol<br>* 200 mg mifepristone and after 48 hours vaginal misopristol 800 mgr followed by oral misopristol 400 mgr every 3 hours for maxamum 5 doses<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Success rate of abortion |  | 24 hours | 
| Interval to abortion |  | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Side effects |  | 24 hours |
Impact of Mothers Touch Program on Women's Psychological Functioning

Study Overview
=================
Brief Summary
-----------------
The study investigates the effect of the Mothers Touch program on the psychological well-being of new mothers following 5 weeks of child birth. Mothers Touch Program is designed based on traditional Indian post-partum care given by trained carer in the family. Study was designed as cohort, including a randomised controlled trial.

Official Title
-----------------
The Role of Indian Post-partum Care in Women's Psychological Functioning

Conditions
-----------------
Psychological Distress, Post Partum Depression, Mood

Intervention / Treatment
-----------------
* Other: Mothers Touch Program


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy women giving birth for first time (primiparous) Given informed consent Accepts traditional home care Exclusion Criteria: Previous history of mental health condition History drug or substance abuse

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Mother Touch Program<br>Forty days of rest period of the mother after delivery, Full body massage, diet and belly binding methods were administered by trained carer. | Other: Mothers Touch Program<br>* Combination of diet, massage, body binding methods along with 40 days of rest following the traditional way of delivering<br>|
| Usual care Program<br>comparison cohort were followed in usual care under the supervision of health professionals. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Post Natal Depression | Edinburgh Postnatal depression Scale | 6 weeks following child birth | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| General well being | General Physical and psychological well being was assessed using General Health Questionnaire | 6 weeks following child birth | 
| Parent-Infant Relationship | Parent-Infant Relationship Global Assessment Scale | 6 weeks following child birth | 
| Maternal Confidence | Maternal Self-Confidence Scale | 6 weeks following child birth |
Detection of Functioning Pituitary Microadenoma: PET/MRI Versus PET/CT

Study Overview
=================
Brief Summary
-----------------
This is a prospective case-control study to compare the usefulness of 18F-FDG PET/MRI with that of 18F-FDG PET/CT in detection of functioning pituitary microadenomas.A single dose of 370 Mega-Becquerel (MBq) 18F-FDG will be injected intravenously.Visual and semiquantitative method will be used to assess the PET/MRI and PET/CT images.

Detailed Description
-----------------
Magnetic resonance imaging (MRI) may be insufficient to locate functioning pituitary microadenoma.This study compared the usefulness of 18F-FDG PET/MRI with that of 18F-FDG PET/CT in detection of functioning pituitary microadenomas in patients with inconclusive conventional MRI findings. Trans-sphenoidal adenomectomy was performed within 2 weeks of imaging.The PET/CT and PET/MRI findings and tracer uptake levels were correlated with the surgical findings and pathological results.

Official Title
-----------------
Detection of Functioning Pituitary Microadenoma With Inconclusive MRI Findings: PET/MRI Versus PET/CT

Conditions
-----------------
Pituitary Adenoma

Intervention / Treatment
-----------------
* Drug: 18F-FDG


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients who were pathologically diagnosed with pituitary adenoma after surgery were recruited, and were able to provide basic information and sign the written informed consent form. Exclusion Criteria: The exclusion criteria included claustrophobia, kidney or liver failure, and inability to fulfill the study.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Interventional Model Description: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 18F-FDG PET/MRI and 18F-FDG PET/CT<br>The patients were injected with 370 MBq of 18F-FDG in one dose intravenously and underwent PET/MRI or PET/CT scan 1 hour later | Drug: 18F-FDG<br>* Single-dose 18F-FDG were injected into the patients before the PET/MR or PET/CT scans. patients before the PET/CT scans<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Standardized uptake value of 18F-FDG in pituitary adenoma | The semiquantitative analysis will be performed by the same person for all the cases, and the standardized uptake value (SUV) of the tracer in pituitary adenoma will be measured | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adverse events collection | Adverse events within 1 week after the injection and scanning of patients and patients will be followed and assessed | 1 week |
Phototoxicity Potential of NatrOVA Creme Rinse - 1%

Study Overview
=================
Brief Summary
-----------------
This study will evaluate the primary irritation potential of NatrOVA Creme Rinse - 1% in humans, after exposure to UV radiation.

Official Title
-----------------
Phase 1 Evaluation of the Phototoxic Potential of NatrOVA Creme Rinse - 1% in Healthy Volunteers

Conditions
-----------------
Head Lice

Intervention / Treatment
-----------------
* Drug: Spinosad (the active ingredient in NatrOVA)
* Drug: placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male or female subjects 18-65 years of age and in good health. Fitzpatrick skin type I, II or III Exclusion Criteria: History of severe reactions from exposure to sunlight Known allergies or sensitivities to adhesives in patches Inability to evaluate the skin in and around the test sites Diabetes requiring medication Clinical significant skin disease Asthma or other severe respiratory disease Known immunological disorders such as HIV, AIDS, lupus,rheumatoid arthritis History or current skin cancer Mastectomy for cancer involving removal of lymph nodes draining the test sites Epilepsy Pregnancy, lactation, or planned pregnancy during study period Chronic use of systemic antihistamine medication within 14 days of screening Use of anti-inflammatory drugs within 2 days of Screening Visit 1 Currently receiving allergy injections Use of immunosuppressive drugs Topical drugs used at the test site within 7 days of Screening Visit 1 Current participation in any clinical trial Participation in any patch test for irritation or sensitization or UV exposures within 4 weeks of study start Use of any investigational drug therapy within 4 weeks of study start.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>NatrOVA Creme Rinse - 1% | Drug: Spinosad (the active ingredient in NatrOVA)<br>* This is a patch test in which the test material is applied to the patch and the patch applied to the skin.<br>|
| Experimental: 2<br>NatrOVA Creme Rinse Vehicle Only | Drug: Spinosad (the active ingredient in NatrOVA)<br>* This is a patch test in which the test material is applied to the patch and the patch applied to the skin.<br>|
| Placebo Comparator: 3<br>Blank patch | Drug: placebo<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Safety endpoint will be visual grading of UV irradiated test sites and assessments of adverse experiences |  | 7 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Head Lice
The Effect of Rigid Taping in Chronic Stroke Patients With Knee Hyperextension

Study Overview
=================
Brief Summary
-----------------
In this study, it is aimed to examine the effect of rigid taping on hyperextension control in stroke patients with knee hyperextension in the stance phase of gait. Hypothesis Ho: Rigid taping has no effect on the control of knee hyperextension in stroke patients. H1: Rigid taping has an effect on the control of knee hyperextension in stroke patients.

Official Title
-----------------
The Effect of Rigid Taping in Chronic Stroke Patients With Knee Hyperextension

Conditions
-----------------
Chronic Stroke

Intervention / Treatment
-----------------
* Other: Rigid Taping


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Having had a stroke at least 6 months ago Ambulation with or without a walking aid (walker, cane or tripod) To be between 0-3 points according to the Modified Rankin Scoring Presence of spasticity in any of the lower extremity muscles with a value of at least 1 according to the Modified Ashworth Scale Getting a score of 24 or higher on the Mini Mental Test Presence of hyperextension in the stance phase of gait Exclusion Criteria: Having more than one stroke history Being diagnosed with dementia Having a previous diagnosis of orthopedic, psychiatric or other neurological disease Having a situation that prevents communication History of surgery or joint contracture involving the lower extremities and gait

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Chronic stroke patients with knee hyperextension<br> | Other: Rigid Taping<br>* Rigid taping was applied to stroke patients with knee hyperextension.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vicon Motion Capture System | A total of 16 reflective signs will be placed on certain anatomical points of the participants. Gait analysis will be performed at a distance of 5 meters from the participants. The three-dimensional positions of the reflective marks will be recorded with the 8-camera Vicon motion capture system. | Baseline | 
| Blade Software System | Data obtained from Vicon motion capture system will be processed with Blade software. With the blade software, kinematic data will be obtained in the computer environment. | Baseline | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Gait Analysis, Stroke, Knee Hyperextension, Rigid Taping
Uterus Transplantation by Robotics - Gothenburg III

Study Overview
=================
Brief Summary
-----------------
Robotic assisted organ procurement and robotic assisted transplantation in live donor uterus transplantation

Detailed Description
-----------------
Inclusion; absolute uterine factor infertility, age between 18 and 38, BMI less than 28, non-smoker

Official Title
-----------------
Uterus Transplantation by Robotics and in Donor and Recipient

Conditions
-----------------
Absolute Uterine Factor Infertility

Intervention / Treatment
-----------------
* Procedure: Robotic surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Uterine factor infertility, age 18-38 years, psychological stable, in steady relationship. Exclusion Criteria: Smoking, systemic disease, psychological instability

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 38 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Robotic surgery<br>Robotic surgery in both live donor and recipient | Procedure: Robotic surgery<br>* Robotoc surgery (Da Vinci) in both donor and recipient<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Surgical success | Uterus with viability and regular menstruations | 0-4 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pregnancy rate | Pregnancy rate per ET | 10-48 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
uterus, infertility, transplantation, robotics