Effect of Traditional Chinese Medicine (TCM) on Embryo Implantation in In-vitro Fertilization (IVF) Patients

Study Overview
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Brief Summary
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To investigate the impact of traditional Chinese medicines (TCM) on embryonic implantation in the patients who have underwent in vitro fertilization and embryo transfer, the investigators compare the pregnancy rate in traditional Chinese medicine group and control group. The hypothesis is that pregnancy rate in traditional Chinese medicine group is higher than the control group.

Detailed Description
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To demonstrate the impact of traditional Chinese medicine (TCM) on embryo implantation, the investigators perform a prospective randomized study on patients who have underwent in vitro fertilization and embryo transfer (IVF-ET) in the Reproductive Medical Center of the Remin Hospital Wuhan University in the next six months. These patients were randomly divided into two groups, one group was given traditional Chinese medicine, that is, ten days oral administration of Zhuyun recipe from the day after HCG injection. The second group without any treatment, and then the pregnancy rate were observed. Frozen embryo transfer for patients do the same treatment, measured indices were also the same in both groups. Our hypothesis is that Zhuyun recipe is beneficial for embryo implantation in IVF-ET patients, it can be found that pregnancy rate in traditional Chinese medicine group is higher than the control group.

Official Title
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Effect of Traditional Chinese Medicine (TCM) on Embryo Implantation in In-vitro Fertilization (IVF) Patients

Conditions
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In Vitro Fertilization and Embryo Transfer

Intervention / Treatment
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* Drug: Traditional Chinese medicine(Zhuyun Recipe)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: aged 18-35 years old undergo IVF/ICSI-ET treatment undergo fresh/ frozen embryos transplantation Exclusion Criteria: the numbers of embryos transplantation were more than one serum estradiol level > 5000 pg/ml and progesterone level > 9. 54 nmol/L on the day of HCG administration

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: traditional Chinese medicine<br>The pregnancy rate in traditional Chinese medicine group is higher than the control group | Drug: Traditional Chinese medicine(Zhuyun Recipe)<br>* The patients undergoing IVF-ET take orally traditional Chinese medicine(Zhuyun Recipe) for ten days.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pregnancy rate | 12 days after embryo transplantation, the investigators measured blood hCG level in the patients and its level > 10IU/L as a biochemical pregnancy, 4 weeks after transplantation, gestational sac and the beating heart were found as clinical pregnancy. | Six months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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embryonic implantation, endometrial receptivity, traditional Chinese medicines, in vitro fertilization-embryo transfer, pregnant rate