Early Diagnosis in Glaucoma With GDxVcc

Study Overview
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Brief Summary
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To compare the Retina Nerve Fiber Layer thickness, measured with Scanning Laser Polarimetry in subjects with exfoliation syndrome and normal controls and to evaluate the value of scanning laser polarimetry in the early diagnosis and management of exfoliative glaucoma

Detailed Description
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To compare the Scanning Laser Polarimetry findings in subjects with exfoliation syndrome and normal controls and to evaluate the value of scanning laser polarimetry in the early diagnosis and management of exfoliative glaucoma. Prospective study in progress. The investigators compare and analyze the scanning laser polarimetry parameters in consecutive subjects with exfoliation syndrome and normal intraocular pressure and compared them with consecutive normal controls. Randomly selected patients with exfoliation syndrome and normal controls undergo a comprehensive ophthalmic exam which includes 3 IOP measurements, corneal pachymetry, automated perimetry and assessment of the retina nerve fiber layer with scanning laser polarimetry. The investigators hypothesize that patients with exfoliation syndrome may show worse scanning laser polarimetry parameters than normal controls and this may prove to be an early sign of exfoliative glaucoma development. Evaluation of retina nerve fiber layer thickness may help us in identifying earlier those individuals with exfoliation syndrome that will develop exfoliative glaucoma.

Official Title
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Evaluation of Scanning Laser Polarimetry Findings in Individuals With Exfoliation Syndrome Compared With Normal Controls

Conditions
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Exfoliation Syndrome

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Exfoliation material on pupil Intraocular pressure below 21 mm Hg without therapy No glaucomatous damage Age between 60-75 Open angle Exclusion Criteria: Other Ophthalmic diseases Dry eye Corneal disorders Diabetic Retinopathy Optic Neuropathy (other than glaucomatous neuropathy) Ocular surgery or laser

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Normal Controls<br>Normal age matched controls without exfoliation | |
| Exfoliation Syndrome<br>Patients with exfoliation syndrome | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Scanning laser polarimetry parameters, evaluation of retina nerve fiber layer thickness |  | Morning measurement (10:00 - 13:00) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Corneal thickness, exfoliation syndrome subjects that will develop exfoliation glaucoma |  | 10:00-13:00 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Exfoliation, Scanning Laser Polarimetry, Corneal Thickness