Hematopoetic Stem Cell Transplant and Physical Function

Study Overview
=================
Brief Summary
-----------------
This study will determine if a structured walking intervention will help maintain or improve physical activity levels, physical function and quality of life in hematopoietic stem cell transplant patients.

Detailed Description
-----------------
The researchers will quantify the decline in physical function of HSCT patients using valid and reliable tests aimed to mimic activities of daily living, quantify cardiovascular health, and quantify muscle power declines. Also, patients will undergo a walking program during their hospitalization, which is designed to increase physical activity levels and maintain and improve physical function and quality of life. Additionally, using valid and reliable questionnaires, the researchers will gauge perception of exercise, quantify current exercise levels, determine preference of exercise programs and counseling, and measure differences in quality of life before and after HSCT treatment.

Official Title
-----------------
Effects of a Multidirectional Walking Program on Physical Function and Quality of Life in Hematopoetic Stem Cell Transplant Patients

Conditions
-----------------
Cancer, Walking

Intervention / Treatment
-----------------
* Other: Walk Training and Transplant
* Other: Activity Monitoring and Transplant


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Be between 40 and 80 years of age Willing and able to provide written informed consent in English Ability to comprehend the purpose of the study Be scheduled to receive an autologous or allogeneic hematopoietic stem cell transplant at Sylvester Comprehensive Cancer Center Have an expected hospital stay of at least 2 weeks Not currently be participating in an exercise training program Exclusion Criteria: Dementia, altered mental status, or psychiatric condition Received erythropoiesis-stimulating proteins within 4 weeks prior to enrollment Comorbid conditions that would contraindicate exercise testing Undergoing concurrent non-transplant-related chemotherapy or radiation

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Walk training and transplant<br>Multidirectional walk training with activity monitoring after bone marrow transplant | Other: Walk Training and Transplant<br>* Subjects will receive free activity monitors and have three training sessions per week for the duration of their bone marrow transplant treatment<br>|
| Experimental: Activity Monitoring and transplant<br>Activity monitoring alone after bone marrow transplant. | Other: Activity Monitoring and Transplant<br>* Subjects will receive free activity monitors for the duration of their bone marrow transplant treatment<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The Physical Performance Test Battery | Physical Function | 10 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Functional Assessment of Cancer Therapy: Bone Marrow Transplant Questionaire Related Quality of Life | Health-related quality of Life | 20 minutes | 
| Patient Reported Outcome Measurement Information System | Health Related Quality of Life | 20 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cancer, Exercise, Physical Function