The Study of Post-operation Delirium and Prognosis of Cardiac Surgery Patients

Study Overview
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Brief Summary
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Delirium is the most common neurological complication of cardiac surgery patients and associated with poor prognosis. In recent years, the important role of quantitative electroencephalogram (qEEG) in brain function monitoring is becoming increasingly prominent. The purpose of this study is to evaluate the effect of qEEG in predictive of post-operation delirium and prognosis of cardiac surgery patients.

Official Title
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the Effect of Quantitative Electroencephalogram (qEEG) in Predictive of Post-operation Delirium and Prognosis of Cardiac Surgery Patients

Conditions
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Delirium

Intervention / Treatment
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* Device: quantitative electroencephalogram (qEEG)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The patients of cardiac surgery aged ≥18 years Signed informed consent Exclusion Criteria: Patients with a history of any neurologic and psychiatric disease Cognitive disorder Stroke history in three years

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Delirium Group<br>The cardiac surgery patients with delirium receive the quantitative electroencephalogram (qEEG) monitoring within 1 hour when they admitted to ICU | Device: quantitative electroencephalogram (qEEG)<br>* the patients receive the quantitative electroencephalogram (qEEG) monitoring within 1 hour when they admitted to ICU<br>|
| Non-delirium Group<br>The cardiac surgery patients without delirium receive the quantitative electroencephalogram (qEEG) monitoring within 1 hour when they admitted to ICU | Device: quantitative electroencephalogram (qEEG)<br>* the patients receive the quantitative electroencephalogram (qEEG) monitoring within 1 hour when they admitted to ICU<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| amplitude integrated electroencephalogram (aEEG) | the electroencephalogram amplitude of cardiac surgery patients assessed by quantitative electroencephalogram when admitted to intensive care unit | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| alpha frequency band energy | the percentage of alpha frequency band of cardiac surgery patients assessed by quantitative electroencephalogram when admitted to intensive care unit | 24 hours | 
| beta frequency band energy | the percentage of beta frequency band of cardiac surgery patients assessed by quantitative electroencephalogram when admitted to intensive care unit | 24 hours | 
| theta frequency band energy | the percentage of theta frequency band of cardiac surgery patients assessed by quantitative electroencephalogram when admitted to intensive care unit | 24 hours | 
| delta frequency band energy | the percentage of delta frequency band of cardiac surgery patients assessed by quantitative electroencephalogram when admitted to intensive care unit | 24 hours | 
| alpha variability | the variability of alpha frequency band of cardiac surgery patients assessed by quantitative electroencephalogram when admitted to intensive care unit | 24 hours | 
| arterial oxygen saturation (SaO2) | the level of arterial oxygen saturation (SaO2) of cardiac surgery patients when admitted to intensive care unit | 24 hours | 
| central venous oxygen saturation (ScvO2) | the level of central venous oxygen saturation(ScvO2) of cardiac surgery patients when admitted to intensive care unit | 24 hours | 
| neuron specific enolase (NSE) | the level of neuron specific enolase (NSE) of cardiac surgery patients when admitted to intensive care unit | 24 hours | 
| interleukin-6 (IL-6) | the level of interleukin-6 (IL-6) of cardiac surgery patients when admitted to intensive care unit | 24 hours | 
| troponin i (TNI) | the level of troponin i (TNI) of cardiac surgery patients when admitted to intensive care unit | 24 hours | 
| high-sensitivity C-reactive protein (hs-CRP) | the level of high-sensitivity C-reactive protein (hs-CRP) of cardiac surgery patients when admitted to intensive care unit | 24 hours | 
| N-terminal pro brain natriuretic peptide (NT-pro-BNP) | the level of N-terminal pro brain natriuretic peptide (NT-pro-BNP) of cardiac surgery patients when admitted to intensive care unit | 24 hours |