The Effects of Acute Ketone Monoester Supplementation on 20-Minute Time-Trial Performance in Trained Cyclists

Study Overview
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Brief Summary
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Diet can alter blood ketone levels and this in turn may affect exercise capacity. This study will determine if the acute ingestion of a ketone supplement alters cycling time trial performance. Participants will perform two trials in a randomized order. Each trial will involve a 20-minute bout of cycling on a stationary ergometer. Participants will ingest either a ketone supplement or a taste-matched placebo drink prior to exercise. Blood samples will be obtained to assess selected metabolic responses. This study will provide information regarding the effect of ketone supplementation on exercise responses.

Detailed Description
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This study will determine if the acute ingestion of a ketone supplement alters cycling time trial performance. Trained participants with competitive cycling experience will be recruited. Exercise will involve a 20-minute bout of cycling on a stationary ergometer with the goal of producing the highest power output possible. Participants will ingest either a ketone supplement or a taste-matched placebo drink prior to exercise using a randomized, double-blind crossover design. Diet prior to exercise will be standardized between trials for a given participant. Blood samples will be obtained to assess selected metabolic responses. This study will provide information regarding the effect of ketone supplementation on exercise responses.

Official Title
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The Effects of Acute Ketone Monoester Supplementation on 20-Minute Time-Trial Performance in Trained Cyclists

Conditions
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Exercise, Ketosis

Intervention / Treatment
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* Dietary Supplement: Ketone monoester
* Other: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Habitually ingesting >50 g of dietary carbohydrate daily i.e. not following a ketogenic diet. Regularly performing cycling exercise at least 3 days per week and for a total of ≥5 hours per week. Having an estimated peak oxygen uptake of ≥55 ml/kg/min for males and ≥48 ml/kg/min for females based on the online fitness calculator available at: www.worldfitnesslevel.org. Having competitive cycling experience. Exclusion Criteria: - Experiencing a condition that might preclude safe participation in physical activity and exercise, as determined by answering Yes to any question on Page 1 of the Canadian Society for Exercise Physiology Get Active Questionnaire.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Ketone<br>An acute bout of exercise performed after the ingestion of a commercial ketone monoester supplement. | Dietary Supplement: Ketone monoester<br>* A commercial liquid supplement ingested in a dose intended to provide  0.35 g of ketone monoester per kg body mass of the participant<br>|
| Placebo Comparator: Control<br>An acute bout of exercise performed after the ingestion of a taste-matched placebo supplement. | Other: Placebo<br>* A liquid placebo that is volume- and taste-matched to the ketone monoester supplement<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Power output | Mean power output produced while cycling | 20-minute measurement during exercise | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart rate | Mean heart rate while cycling | 20-minute measurement during exercise | 
| Perceived exertion | Rating of perceived exertion while cycling | Single measurement immediately after exercise | 
| Blood ketone | Blood ketone before exercise | Single measurement immediately prior to exercise | 
| Blood glucose | Mean blood glucose while cycling | 20-minute measurement during exercise | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Performance