linjc16/ctgov huggingface dataset:
Gut Oxygenation and Laparoscopy

Study Overview
=================
Brief Summary
-----------------
Patients with left-colon cancer will be randomized to laparoscopic or laparotomic operation. during surgery and for 6 days after operation, intestinal oxygen tension and ischemia-reperfusion injury markers will be evaluated to understand if pneumoperitoneum is associated with reduced splanchnic blood flow and ischemia-reperfusion injury.

Official Title
-----------------
GUT OXYGENATION DURING AND AFTER LAPAROSCOPIC AND OPEN COLON RESECTION. A RANDOMIZAD CLINICAL TRIAL

Conditions
-----------------
Laparoscopy, Laparotomy, Oxygenation,, Ischemia-Reperfusion Injury

Intervention / Treatment
-----------------
* Procedure: Laparoscopy
* Procedure: left colectomy by laparotomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Proven Cleft Colon Cancer, Signed Informed Consent Exclusion Criteria: Emergency surgery, Cancer infiltrating adjacent organ (at CT scan), Severe cardiovascular (New York Heart Association class > 3 ), Respiratory (arterial PO2 < 70 mmHg), Renal (plasma creatinine > 3 MG/dL) or hepatic (Child C) dysfunction

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Laparoscopy<br>Laparoscopic Left-Sided Colectomy | Procedure: Laparoscopy<br>* Laparoscopic Left-Colectomy<br>|
| Active Comparator: laparotomy<br>Laparotomic Left-Sided Colectomy | Procedure: left colectomy by laparotomy<br>* PatientS will be operated by laparotomy<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intestinal oxygenation |  | 7 DAYS | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ischemic reperfusion injury |  | 7 DAYS | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
LAPAROSCOPY,, LAPAROTOMY,, OXYGENATION,, ISCHEMIA-REPERFUSION INJURY
A Chemoprevention Study of an Investigational Drug in Men With High Grade Prostate Intraepithelial Neoplasia (PIN)

Study Overview
=================
Brief Summary
-----------------
If you are a male 30 years of age or older and have a positive diagnosis of high grade (II or III) prostate Intraepithelial Neoplasia (PIN) or have had an abnormal/suspicious prostate biopsy, you may be eligible for this study. This is a study of an investigational medication that may reduce high grade PIN and prevent the occurrence of prostate cancer. This study is currently enrolling up to 500 men at approximately 60 locations in the United States.

Detailed Description
-----------------
High grade PIN is the development of precancerous, abnormal tissue of the prostate gland that puts men at high risk of developing prostate cancer. This study will take one year of participation with clinic visits every three months. There will be two prostate biopsies during the study, at six and twelve months. If qualified to participate, you will be randomly assigned to one of four treatment groups. Three out of four groups are varying doses of the study medication and the other is the placebo group (like a sugar pill).

Conditions
-----------------
Prostatic Intraepithelial Neoplasia

Intervention / Treatment
-----------------
* Drug: GTX-006 (Acapodene)


Participation Criteria
=================
Eligibility Criteria
-----------------
Must have confirmed high grade PIN on prostate biopsy within past 6 months. Must have a serum PSA <12 ng/ml. Can not have prostate cancer. Have significant ocular opacities. Can not take finasteride or other testosterone like supplement.

Ages Eligible for Study
-----------------
Minimum Age: 30 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: GTX-006 (Acapodene)|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
PIN, High Grade Prostate Intraepithelial Neoplasia (PIN)
Procedural Learning in Participants With ADHD

Study Overview
=================
Brief Summary
-----------------
Skill acquisition refers to the process of improvement of performance following practice experience. This process is the basis for generation of a long-lasting memory. Individuals with Attention Deficit Hyperactivity Disorder (ADHD) have been shown to be impaired on some performance aspects of previously learned skills, an impairment that is often ameliorated, at least temporarily, by psychostimulant medication (the standard therapy in ADHD). The proposed study aims to define the course of learning and of generation of long-term memory consolidation in individuals with ADHD, and to essay the effectiveness of psychostimulant medication on both the learning and retention of the skills.

Detailed Description
-----------------
Skill Acquisition and the Evolution of Long Term Procedural Memory in participants with ADHD: The Effect of Methylphenidate

Conditions
-----------------
Attention Deficit Hyperactivity Disorder

Intervention / Treatment
-----------------
* Procedure: Methylphenidate


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Full scale IQ score of 85 or above

Ages Eligible for Study
-----------------
Minimum Age: 12 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Methylphenidate|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Skill Acquisition and the Evolution of Long Term Procedural Memory in participants with ADHD: The Effect of Methylphenidate
Assessment of Blood Glucose Monitoring Systems - Evaluation of Oxygen Dependency

Study Overview
=================
Brief Summary
-----------------
Systems for blood glucose monitoring with glucose oxidase enzyme reaction on test strips can be affected by the partial pressure of oxygen of the blood sample. In this study, we investigate the influence of different partial pressure of oxygen in blood samples on measurement results. Systems with labelled oxygen-dependency as well as systems without labelled oxygen-dependency are evaluated.

Official Title
-----------------
Prüfung Von Blutzuckermesssystemen - Bewertung Der Sauerstoffabhängigkeit

Conditions
-----------------
Diabetes

Intervention / Treatment
-----------------
* Device: 6 blood glucose monitoring systems for self-testing


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years of age or older male or female subjects with type 1 or type 2 diabetes or healthy subjects signed informed consent form Exclusion Criteria: pregnancy or lactation period severe acute illness that, in the opinion of the investigator, might pose additional risk to the subject severe chronic illness that, in the opinion of the investigator, might pose additional risk to the subject

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: 6 blood glucose monitoring systems for self-testing|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Influence of the blood sample's partial pressure on blood glucose measurement results |  | For each sample, preparation and measurment procedure have an expected duration of about 2 hours |
Protocol to Permit the Acquisition of Circulating Tumor Material in Pancreatic Diseases

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to collect blood samples to detect potential markers of pancreatic cancer in the blood and link these findings to medical and health information. Information from this study may help to provide insight into the detection of pancreas cancer in the blood before it can be found by other methods or provide a method of monitoring the status of pancreatic cancer throughout a treatment course. Another purpose of this study is to collect blood to create a biobank.

Official Title
-----------------
Protocol to Permit the Acquisition of Circulating Tumor Material in Pancreatic Diseases

Conditions
-----------------
Pancreatic Diseases

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The subject must be a patient at the Hospital of the University of Pennsylvania The subject must be under evaluation and/or treatment for a pancreatic disease The subject must be under evaluation and/or treatment for a non-pancreatic disease. For example, patients undergoing routine colonoscopy within the clinical practice will be asked to consent to provide control samples. The subject must be able to provide informed consent or have an acceptable surrogate capable of giving consent on the subject's behalf The subject must be 18 years of age or older Exclusion Criteria: The subject or acceptable surrogate does not provide informed consent Subject is a prisoner Subject is under 18 years of age

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Collection of blood and tissue samples from subjects with pancreatic diseases |  | 3 years |
Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit

Study Overview
=================
Brief Summary
-----------------
In clinical practice, the oxidative stress is related to circulatory shock, sepsis, acute lung injury, and acute respiratory distress syndrome. There are some questions on the oxidative stress of the critical illness. First, the investigators want to search out the effects of the past history, smoking, alcohol drinking, use of antioxidants, different diseases, and different duration of SIRS on the degree of oxidative stress. Second, besides total count of ROS, the investigators used new techniques to determine superoxide(O2●-), hydrogen peroxide (H2O2), and hypochlorous acid(HOCl). Furthermore, we want to investigate the correlation of the degree of different reactive oxygen species and the severity of SIRS or shock. Third, we try to investigate the correlation between the change of oxidative stress and the prognosis of the patients. The investigators wish this study will help them to investigate the effect of oxidative stress on critical ill patients, to modulate the oxidative stress, to decrease the occurrence of SIRS, shock, and multiorgan failure, and to improve the long term outcome of patients.

Official Title
-----------------
Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit

Conditions
-----------------
Sepsis, Shock

Intervention / Treatment
-----------------
* Other: Chemiluminescence Analyzer


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age > 18 y/o Admitted to surgical ICU Exclusion Criteria: Patients with brain death

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>age > 18 y/o Patients admitted to surgical ICU | Other: Chemiluminescence Analyzer<br>* measure reactive oxygen species<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 28-day Survival |  | 28 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Days stay in ICU Days on ventilator SOFA score Complications |  | 28 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
oxidative stress, intensive care, Postoperative intensive care
The EC90 of Remifentanil Blunting Hemodynamic Changes to Head Fixation

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to estimate the EC90 of remifentanil blunting hemodynamic changes to head fixation in the patients undergoing neurosurgery.

Official Title
-----------------
The EC90 of Remifentanil Blunting Hemodynamic Changes to Head Fixation in the Patients Undergoing Neurosurgery

Conditions
-----------------
AVM, Brain Tumor, ICH

Intervention / Treatment
-----------------
* Drug: remifentanil


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients undergoing neurosurgery that require head fixation with mayfield head holder patients who agree to our study Exclusion Criteria: patients who don't agree to our study BMI<16.0 or BMI>30 cardiovascular disease, pulmonary disease, renal disease alcoholic abuser or drug abuser patients who takes any drug having an influence on cardiovascular system or sympathetic nervous system any use of local anesthetics or drugs which have an influence on cardiovascular system from beginning of induction to peri-fixation period

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: neurosurgery with fixation<br> | Drug: remifentanil<br>* According to previous patient's response, the investigators will allocate the effect site concentration of remifentanil of next patient during head fixation. And, For this allocation of dose of remifentanil the investigators use biased coin design up-and-down method. For the first patient, the dose of remifentanil would be fixed at 5.5ng/ml which we predict as EC90. And, step size of dose is 0.5ng/ml.<br>* Other names: Biased coin design up-and-down method.;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mean arterial blood pressure | mean arterial blood pressure will be recorded at 2 minutes before fixation, 1 minute before fixation, highest value during immediately post-fixation periord, 1 minute after fixation, 2 minutes after fixation, 3 minutes after fixation, 4 minutes after fixation and 5 minutes after fixation. | peri-fixation periord | 
| heart rate | heart rate will be recorded at 2 minutes before fixation, 1 minute before fixation, highest value during immediately post-fixation periord, 1 minute after fixation, 2 minutes after fixation, 3 minutes after fixation, 4 minutes after fixation and 5 minutes after fixation. | peri-fixation periord |
The ALERT-Pilot Study

Study Overview
=================
Brief Summary
-----------------
the algorithm of artificial intelligent to diagnose myocardial infarction through prior surgery Electrocardiogram was established. The accuracy of using artificial intelligent to diagnose acute ST-segment elevation myocardial infarction and judge criminal vascular was evaluated.

Official Title
-----------------
Automatic Diagnosis of ST-segment Elevated Myocardial Infarction by Artificial Intelligence-based Electrocardiographic System:The ALERT-Pilot Study

Conditions
-----------------
ECG Pattern, Myocardial Infarction, Acute, Artificial Intelligence

Intervention / Treatment
-----------------
* Diagnostic Test: electrocardiogram diagnosed by artificial intelligence


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age≥18 years old; the admitting doctor's diagnosis is ST-segment Elevation Myocardial Infarction. Exclusion Criteria: the admitting diagnosis is non-ST-segment Elevation Myocardial Infarction. default data; pregnancy, mental disorder, kidney failure; except for criteria mention above, including some improper condition considered by investigators.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| ST segment Elevation Myocardial Infarction<br>ST segment Elevation Myocardial Infarction patients' diagnosis was confirmed by coronary artery angiography. The prior surgery electrocardiogram need to be collected. | Diagnostic Test: electrocardiogram diagnosed by artificial intelligence<br>* According to coronary angiogram results, the accuracy of STEMI patients' electrocardiogram diagnosis by artificial intelligence was evaluated.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the algorithm of artificial intelligent to diagnose myocardial infarction through prior surgery Electrocardiogram | All the electrocardiograms done before coronary arteriography were read by artificial intelligent. Then according to results of coronary angiogram, artificial intelligent can establish a algorithm of to diagnose myocardial infarction. | 24 hours | 
| The accuracy of using artificial intelligent to diagnose acute ST-segment elevation myocardial infarction and judge criminal vascular | The accuracy of using artificial intelligent to diagnose acute ST-segment elevation myocardial infarction and judge criminal vascular was evaluated. | 24 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
myocardial infarction, artificial Intelligence, 12 lead electrocardiogram
Serum Markers in Preeclamptic Women

Study Overview
=================
Brief Summary
-----------------
Could possible markers in serum obtained in the first trimester predict the human-pregnancy specific disorder pre-eclampsia?

Conditions
-----------------
Preeclampsia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: previous healthy Exclusion Criteria: Previous inflammatory diseases
Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| preeclampsia<br>Control group: 86 healthy women not developing preeclampsia (PE) Case group: 43 women developing PE | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Preeclampsia, serological bio-bank, adiponectin, suPAR
Quality of Life in Food Allergic Families

Study Overview
=================
Brief Summary
-----------------
Food allergies are becoming more prevalent with more children being diagnosed with food allergies each year. Food allergies place a tremendous burden not just on the patient but on his/her family as well. In an attempt to provide better care to the investigators patients, the investigators would like to determine if regular contact with our food allergy nurse has a positive effect on a family's perceived quality of life.

Detailed Description
-----------------
We intend to show a difference between the intervention group, who will receive a food allergy packet, along with three follow up phone calls from our trained allergy nurse, and the control group, will be given the food allergy packet only. We expect the intervention group to score higher on the quality of life survey, showing that the support and education of our allergy nurse has a positive effect on quality of life of our patients and their families.

Official Title
-----------------
Quality of Life in Food Allergic Families

Conditions
-----------------
Food Allergy

Intervention / Treatment
-----------------
* Behavioral: Counseling
* Behavioral: Placebo phone call


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: IgE mediated food allergy Ages 0-17 Willing to participate Exclusion Criteria: Food sensitivities Unable to understand or read survey Unable to be available for follow up survey and nurse phone calls.

Ages Eligible for Study
-----------------
Maximum Age: 17 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Education and counseling<br>Phone calls using behavioral techniques | Behavioral: Counseling<br>* Our food allergy nurse will contact our intervention group and discuss any questions or concerns they may have regarding their child's food allergy.<br>|
| Placebo Comparator: Control<br>Single phone call | Behavioral: Placebo phone call<br>* Phone call w/ no behavioral counseling<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in validated quality of life survey |  | twelve months |