Incomplete Total Body Protein Recovery in Adolescent Patients With Anorexia Nervosa

Study Overview
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Brief Summary
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The study aimed to assess protein accretion during weight gain in adolescent patients with Anorexia nervosa

Detailed Description
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Background: Bone health and growth during adolescence require adequate Total Body Protein (TBPr). Re-nutrition for patients with anorexia nervosa (AN) should aim to normalize body composition, i.e. recovery of fat mass and TBPr. Objective: The study intended to analyze predictors of protein status, including exercise status, in adolescents with AN, and to investigate whether weight gain would replete body protein deficits. Methods: The investigators assessed TBPr in a longitudinal, observational study as height-adjusted nitrogen index (NI) using in-vivo neutron activation analysis in adolescents with AN at the commencement of refeeding (T0), as well as seven months thereafter (T1), and in age-matched normal weight controls. Lean tissue and fat mass were assessed with Dual-Energy X-Ray Absorptiometry (DXA). BMI, BMI-SDS and lean tissue mass were tested as predictors of protein status using Receiver Operating Characteristic (ROC) analysis.

Official Title
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Incomplete Total Body Protein Recovery in Adolescent Patients With Anorexia Nervosa

Conditions
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Anorexia Nervosa

Intervention / Treatment
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* Other: Inpatient treatment for Anorexia nervosa


Participation Criteria
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Eligibility Criteria
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Patient Inclusion Criteria: diagnosis of anorexia nervosa (DSM-IV) aged 12 - 19 years female gender Patient Exclusion Criteria: - existence of a further disease with effect on body composition Controls: no known disease normal weight

Ages Eligible for Study
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Minimum Age: 12 Years
Maximum Age: 19 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Inpatient treatment for Anorexia nervosa<br>Adolescents with anorexia nervosa assessed at baseline: on admission to inpatient treatment at follow-up: 6 months after admission on outpatient basis | Other: Inpatient treatment for Anorexia nervosa<br>* Nutritional rehabilitation in a clinic with specialized eating disorder service<br>|
| Controls<br>Adolescent healthy and normal weight controls (matched for gender and age), assessed at one point of time | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Total Body protein | Change in Total Body protein | Between baseline (inpatient admission) and at 7 months follow-up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in body weight | Change in: body weight (kg) | Between baseline (inpatient admission) and at 7 months follow-up | 
| Change in Body Mass Index | Change in Body Mass Index (BMI; kg/m2) | Between baseline (inpatient admission) and at 7 months follow-up | 
| Change in body fat mass | Change in body fat mass (kg) | Between baseline (inpatient admission) and at 7 months follow-up | 
| Change in body lean tissue mass | Change in body lean tissue mass (kg) | Between baseline (inpatient admission) and at 7 months follow-up | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Body composition, Total body protein, nutritional recovery, Exercise status, In-vivo neutron activation analysis, Protein depletion