The Efficacy of Adductor-Canal-Blockade on Morphine Consumption, Pain and Mobilisation After Total Knee Arthroplasty

Study Overview
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Brief Summary
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The purpose of this study is to determine whether Adductor-Canal-Blockade is effective at reducing morphine consumption and pain, and at the same time improving mobilisation after total knee arthroplasty.

Official Title
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The Efficacy of Adductor-Canal-Blockade on Morphine Consumption, Pain and Mobilisation After Total Knee Arthroplasty

Conditions
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Total Knee Arthroplasty

Intervention / Treatment
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* Procedure: Adductor-Canal-Blockade
* Procedure: Adductor-Canal-blockade with saline


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Total Knee Arthroplasty in spinal anaesthesia ASA 1-3 BMI 18-40 Written informed consent Exclusion Criteria: Can not cooperate to the exam Do not speak or understand Danish Drug allergy Alcohol or drug abuse Daily consumption of strong opioids Unable to complete the Timed Up and Go test preoperatively

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Adductor-Canal-Blockade<br>Adductor-Canal-Blockade with ropivacaine | Procedure: Adductor-Canal-Blockade<br>* US-guided Adductor-Canal-Blockade with ropivacaine 7,5 mg/ml<br>* Other names: US-guided nerve block;|
| Placebo Comparator: Adductor-Canal-blockade with saline<br>Adductor-Canal-blockade with isotonic saline | Procedure: Adductor-Canal-blockade with saline<br>* US-guided Adductor-Canal-blockade with saline<br>* Other names: placebo block;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total morphine consumption | Total morphine consumption at the interval 0-24 hours postoperative. | 0-24 hours postoperative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total morphine consumption | Total morphine consumption at the intervals 0-2, 0-4, 0-8 and 0-26 hours postoperative. | 0-26 hours postoperative | 
| Pain during rest | 0-100 mm at a visual analogue scale (VAS), at the intervals 2, 4, 8, 24 and 26 hours postoperative, and the area under the curve for the intervals 2-24 and 24-26 hours postoperative. | 0-26 hours postoperative | 
| Pain during 45 degrees active flexion of the knee | 0-100 mm at a visual analogue scale (VAS), at the intervals 2, 4, 8, 24 and 26 hours postoperative, and the area under the curve for the intervals 2-24 and 24-26 hours postoperative. | 0-26 hours postoperative | 
| A change in pain in the placebo group | 0-100 mm at a visual analogue scale (VAS), at the intervals 24 and 26 hours postoperative. | 24-26 hours postoperative | 
| Postoperative nausea | Nausea scores(0-3)at 2,4,8,24,26 hours postoperative. | 0-26 hours postoperative | 
| Zofran consumption | Total zofran consumption at the intervals 0-24 and 24-26 hours postoperative. | 0-26 hours postoperative | 
| Sedation | Seadtion score (0-3) at 2,4,8,24,26 hours postoperative. | 0-26 hours postoperative | 
| Mobilisation | Number of seconds it takes to complete the Timed Up and Go test, at 20 and 26 hours postoperative. | 20-26 hours postoperative | 
| Postoperative vomiting | Number of vomiting episodes at the intervals 0-2,2-4,4-8,8-24,24-26 hours postoperative. | 0-26 hours postoperative | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Adductor-Canal-Blockade, postoperative pain, US-guided nerve block, total knee arthroplasty