Physical Rehabilitation and Chronic Kidney Disease

Study Overview
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Brief Summary
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Older patients with chronic renal failure suffer from sarcopenia. Loss of muscle function is associated with increased morbidity and mortality. Currently few treatment are available. The aim of this study is to evaluate the impact of physical rehabilitation in this population on muscle performance and quality of life.

Official Title
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Impact of Physical Rehabilitation on Sarcopenia Inolder and Chronic Kidney Patients

Conditions
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Sarcopenia, Chronic Kidney Disease, Older

Intervention / Treatment
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* Behavioral: Physical rehabilitation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: man or woman age over 70 years CKD stage 3B, 4 or 5 or a DFG <45ml / min according to CKD-EPI formula an SPPB (Short Physical Performance Battery test )<10 having received a complete and loyal information and having given his written and informed consent. ability to rehabilitate Exclusion Criteria: Subject not presenting previous inclusion criteria General condition not compatible for the realization of physical rehabilitation Patient protected under the terms of the law. Inability to respect the follow-up of the study for geographical, social or psychological reasons. depression or other psychiatric disorder Refusal to participate in the study Absence of affiliation to the social security system Subject in a exclusion period of an other study

Ages Eligible for Study
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Minimum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention : Physical rehabilitation<br>The Arm Physical rehabilitation will benefit from the implementation of the Loss of Mobility Prevention program set up in the Department of Aging Medicine of the Center Hospitalier Lyon Sud (CHLS) of Pr BONNEFOY. | Behavioral: Physical rehabilitation<br>* It will benefit from an initial and final geriatric assessment, an initial dietary balance and a personalized treatment in physical activities adapted for 3 months by an Educator in Adapted Physical Activities.<br>|
| No Intervention: Control : optimized medical treatment<br>The Arm Optimized medical treatment will not benefit from the implementation of the Loss of Mobility Prevention program. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from Baseline distance travelled (in meters) during the 6-minute walking distance (6MWD) test (muscular performance), at 3 months |  | Baseline and 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nutritional parameter: Albuminemia |  | Baseline,3 and 6 months | 
| Nutritional parameter: Prealbuminemia |  | Baseline,3 and 6 months | 
| Nutritional parameter: Body mass index |  | Baseline,3 and 6 months | 
| Nutritional parameter: bioimpedancemetry |  | Baseline,3 and 6 months | 
| Muscle strength evaluated by Hand Grip strength test |  | Baseline,3 and 6 months | 
| Quality of life evaluated by the questionnaire SF-36 (36-item medical outcomes study Short-Form health survey) |  | Baseline,3 and 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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sarcopenia, chronic kidney disease, older