Comparation of Ultrasonic Imaging of Enthesopathy in Patients With Psoriatic Arthritis and Psoriasis

Study Overview
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Brief Summary
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Psoriatic arthritis(PsA) and psoriasis(Ps) are two systemic inflammatory diseases linked with rash of psoriasis, but there's still great controversy regarding the exact relationship between them. Our study is to investigate the characteristics and differences of the ultrasonic imaging of enthesopathy in the lower extremity in patients with PsA and Ps, to explore the risk factors of Ps developing into PsA in the long term course.

Detailed Description
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As one of the most common chronic inflammatory skin diseases, psoriasis(Ps) can be intimately associated to psoriatic arthritis (PsA), affecting approximately 1% to 2% of the world's population. About 30% of them will develop into PsA with serious impact on their health-related quality of life. PsA, characterised by different subsets with varying degree of severity, is a chronic, complicated inflammatory disease.Enthesitis is the prevalent and distinctive feature of PsA. Musculoskeletal Ultrasound (MSUS) is a valid noninvasive modality, essential to evaluate entheses thickness, enthesophytes, bursitis and bone erosions as well as to disclose vascularisation on tendons through power doppler (PD) assessment. In recent years, more and more attention has been paid to the diagnosis and management of Ps and PsA, owing to its discrimination of identifying subclinical entheses and joint changes.

Official Title
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Comparation of Ultrasonic Imaging of Enthesopathy in Patients With Psoriatic Arthritis and Psoriasis

Conditions
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Enthesopathy

Intervention / Treatment
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* Device: Musculoskeletal Ultrasound


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical diagnosis of plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, rheumatoid arthritis or osteoarthritis. Body Mass Index (BMI)<30 kg/m2. Absence of local glucocorticoid or other drugs injection or surgical treatment for entheses scanned in the previous 6 weeks prior to clinical and musculoskeletal ultrasound (MSUS) evaluation. Exclusion Criteria: Other systemic rheumatic diseases or malignant neoplasms. Peripheral neuropathy of lower extremity.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Psoriatic Arthritis<br>Musculoskeletal ultrasound (MSUS) of the lower limbs' entheses were performed | Device: Musculoskeletal Ultrasound<br>* Musculoskeletal ultrasound (MSUS) of the lower limbs' entheses were performed<br>|
| Psoriasis<br>Musculoskeletal ultrasound (MSUS) of the lower limbs' entheses were performed | Device: Musculoskeletal Ultrasound<br>* Musculoskeletal ultrasound (MSUS) of the lower limbs' entheses were performed<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The rate of enthesopathy comparison between psoriatic arthritis(PsA) and psoriasis(Ps) as assessed by SPSS v17.0 |  | up to 10 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The potential risk factors of Ps for PsA as assessed by SPSS v17.0 |  | up to 10 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Musculoskeletal Ultrasound, Psoriatic Arthritis, Enthesopathy