Genetic Study of Familial Factors in Patients With Colon Cancer

Study Overview
=================
Brief Summary
-----------------
RATIONALE: Genetic studies may help in understanding the genetic processes involved in the development of some types of cancer. PURPOSE: Clinical trial to study the cancer-related genes in patients who have colon cancer or adenomatous polyps.

Detailed Description
-----------------
OBJECTIVES: Identify human colon neoplasia susceptibility genes in patients with colon cancer or adenomatous polyps. Correlate the inheritance of novel susceptibility alleles for adenomatous polyposis of the colon with colon neoplasia in these patients. Correlate colon neoplasia susceptibility with the presence of COX-2, sPLA2, and DNMT genes in these patients. Identify a novel gene that governs increased susceptibility to colon adenoma and cancer in the genome of these patients.

Official Title
-----------------
Familial Factors in the Development of Colon Cancer

Conditions
-----------------
Colorectal Cancer

Intervention / Treatment
-----------------
* Genetic: cytogenetic analysis
* Genetic: gene mapping
* Genetic: microarray analysis


Participation Criteria
=================
Eligibility Criteria
-----------------
DISEASE CHARACTERISTICS: Diagnosis of colon cancer or polyps at age 70 or under Has a living full sibling with diagnosis of colon cancer or polyps at age 70 or under No history of familial adenomatous polyposis syndrome No hereditary nonpolyposis colon cancer, according to Amsterdam criteria No known I1370K adenomatous polyposis of the colon susceptibility variant Enrolled on 1 of the following clinical trials: CLB-9581 CLB-89803 CLB-80001 NOTE: Patients do not need to be receiving protocol therapy. Patients who are outside the treatment protocol's follow-up range are eligible. Patients who discontinued therapy for any reason, including toxic effects, are eligible. PATIENT CHARACTERISTICS: Age 70 and under at diagnosis Other No significant psychiatric illness that would preclude giving informed consent No inflammatory bowel disease (in patient or sibling)

Ages Eligible for Study
-----------------
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1<br>Patients donate blood samples for analysis of colorectal susceptibility genes. Patients also complete a questionnaire regarding family cancer history. A certificate of confidentiality protecting the identity of research participants in this project has been issued by the National Cancer Institute. Participants do not receive the results of the genetic testing, and the results do not influence the type or duration of treatment. | Genetic: cytogenetic analysis<br> <br> Genetic: gene mapping<br> <br> Genetic: microarray analysis<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
adenocarcinoma of the colon, stage I colon cancer, stage II colon cancer, stage III colon cancer, stage IV colon cancer