Impact of Whole-body Vibration Training on Sarcopenic Elderly

Study Overview
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Brief Summary
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Sarcopenia is defined as a phenomenon which the amount of muscle mass in elderly aged 60-70 years is about 20-30% lower than that of the young adults and middle-aged people due to muscle atrophy caused by aging and alteration in muscle itself in aged skeletal muscle. Whole body vibration(WBV) training can be a choice for hospitalized patients who cannot conduct high intensity resistance training.

Detailed Description
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This study is prospective study. The goal of this study is To investigate the effect of whole body vibration training using vibration platform with tilt table on muscle mass, muscle strength, physical performance in hospitalized older adults with sarcopenia. To demonstrate whether whole body vibration training using vibration platform with tilt table can be useful in hospitalized older adults with sarcopenia who could not perform high intensity exercise.

Official Title
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Impact of Whole-body Vibration Training on Sarcopenia in Geriatric Hospitalized Patients

Conditions
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Sarcopenia

Intervention / Treatment
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* Device: whole body vibration plus conventional therapy
* Procedure: conventional therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: More than 70-year old people who admitted Seoul National University hospital, Bundang. Deconditioning subjects with diabetics, infections, chronic lung disease, etc. who cannot walk independently due to long-term hospital care. Subjects who had a mobility impairment. Subjects who can agree voluntarily. Exclusion Criteria: Subjects who inserted implant due to trauma within 1 2 months recently. Acute coronary syndrome. Uncontrolled hypertension. Subjects who took drugs which can affects neuromuscular system. Severely impaired cognition Subjects who cannot agree volun.tarily.

Ages Eligible for Study
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Minimum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Whole body vibration plus conventional therapy group<br>conventional therapy + whole body vibration training for 40 minutes per day, five days per week for two-week period. | Device: whole body vibration plus conventional therapy<br>* Subjects enrolled in whole body vibration training group are exposed to side-to-side alternating vertical sinusoidal vibration. Galileo system(Novotec Medical GmbH, Pforzheim, Germany) is used to training. Frequency of whole body vibration is 12Hz and amplitude is 4mm. After 10 minutes of vibration training, subjects rest 3 minutes. Then, additional 10 minutes of training will be given. conventional physical therapy is consisted of passive range of motion exercise and walking exercise.<br>|
| Active Comparator: conventional training group<br>conventional therapy (passive range of motion exercise and walking exercise) for 40 minutes per day, five days per week for two-week period. | Procedure: conventional therapy<br>* conventional physical therapy is consisted of passive range of motion exercise and walking exercise.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Berg balance scale | Change from baseline Berg balance scale to 2 weeks after initial assessment. Berg balance scale [from 0 to 56 score] is widely used to assess subjects' ability to control body balance. For '0' score, it means subject cannot maintain his/her own standing balance. For '56' score, he/she can properly keep static/dynamic standing balance. | Before intervention / after two weeks intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximal voluntary isometric contraction at knee | Change from baseline knee extension power to 2 weeks after initial assessment. Using the machine(muscle tester(manual), Lafayett instrument, USA), knee extension power will be measured while subject sit in the chair. | Before intervention / after two weeks intervention | 
| 10 meter walking test | Change from baseline time when performing 10 meter walking test to 2 weeks after initial assessment. The subject was asked to move 10 meter away from baseline. While subject moved, total amount of time was measured. Then, the time used in first 2 meter movement and last time used in last 2 meter movement was excluded. Finally, total time used in 6 meter movement was measured. | Before intervention / after two weeks intervention | 
| Hand grip muscle strength | Change from baseline hand grip strength to 2 weeks after initial assessment. Its assessment is made by Leonardo Mechanograph(Novotec Medical GmbH, Pforzheim, Germany), (unit = N ). For the actual testing procedure, grip strength measurements of the bilateral limb were conducted. The subject was instructed to slowly squeeze the machine. Each measure site was tested one times during 3 seconds. The subjects sit in the chair, maintaining elbow flexed at 90 degree. | Before intervention / after two weeks intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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sarcopenia, vibration, gait, muscle, rehabilitation