PET/CT Scanning for the Follow-up of Antibiotic Treatment of Infectious Osteoarthritis in the Diabetic Foot

Study Overview
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Brief Summary
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The investigators' primary objective is to assess the predictive power of PET/CT scanning in the evolution of infectious osteoarthritis of the diabetic diabetic after antibiotic therapy prescribed by national and international recommendations.

Official Title
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Positron Emission Tomography - Computed Tomography (PET/CT) Scanning for the Follow-up of Antibiotic Treatment of Infectious Osteoarthritis in the Diabetic Foot

Conditions
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Diabetic Foot, Osteoarthritis

Intervention / Treatment
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* Procedure: Bone scintigraphy
* Procedure: Leukoscan
* Procedure: PET / CT
* Procedure: Bone biopsy
* Biological: Bloodwork


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The patient must have given his/her informed and signed consent The patient must be insured or beneficiary of a health insurance plan Patient has type I or type II diabetes Patient consulting in the department of Metabolic and Endocrine Diseases (Caremeau Hospital) or the department of Nutritional Diseases and Diabetology (Grau de Roi Medical Center) at the Nîmes University Hospital Patient has infected osteoarthritis of the foot according to the International Working Group on the Diabetic Foot with a probability > 50% (score >= 2). Exclusion Criteria: The patient is participating in another study The patient is in an exclusion period determined by a previous study The patient is under judicial protection, under tutorship or curatorship The patient refuses to sign the consent It is impossible to correctly inform the patient The patient is pregnant The patient is breastfeeding Patient has severe sepsis or a stage 4 infection according to the international consensus on the diabetic foot Patient has severe renal insufficiency as defined by glomerular filtration rate < 30ml/min/1.73 m^2, calculated according to the MDRD equation, and is not undergoing dialysis Patient has a contra-indication for an MRI pacemaker intracranial clips metallic inclusions severe claustrophobia

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Included patients<br>Patients included in the study according to stated inclusion and exclusion criteria Intervention: Bone scintigraphy Intervention: Leukoscan Intervention: PET / CT Intervention: Bone biopsy Intervention: Bloodwork | Procedure: Bone scintigraphy<br>* Bone scintigraphy of the affected area<br>Procedure: Leukoscan<br>* Scintigraphy with labeled neutrophils<br>Procedure: PET / CT<br>* PET / CT of the affected area<br>Procedure: Bone biopsy<br>* A bone biopsy is performed during pre-inclusion work up.<br>Biological: Bloodwork<br>* CRP and procalcitonin are measured in the pre-inclusion work up.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The difference between AUCs for PET/CT scan and scintigraphy |  | 1 year |