Assessment of Dried Blood Spot Thyroglobulin and Urinary Iodine Concentration in Pregnant Women

Study Overview
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Brief Summary
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To avoid iodine deficiency and its consequences in pregnant women and their offspring, women should reach a sufficient iodine intake long before conception. To monitor iodine status, median urinary iodine concentration (UIC) is widely used in pregnant women (PW). Thyroglobulin (Tg) us another marker used to assess iodine status . In this study, urine samples as well as dried blood spots will be collected to measure UIC and Tg (as well as other hormones to define thyroid function) in PW. The results shall be used to reassess the threshold which defines iodine status in PW according to UIC.

Official Title
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Assessment of Dried Blood Spot Thyroglobulin in Pregnant Women to Redefine the Range of Median Urinary Iodine Concentration That Indicates Adequate Iodine Intake

Conditions
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Iodine Deficiency, Pregnancy Related

Intervention / Treatment
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* Other: no intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Generally healthy No major medical illness, no thyroid disease, and taking no chronic medication No use of iodine containing dietary supplements No use of iodine-containing X-ray /CT contrast agent or iodine containing medication within the last year Aged between 18 and 44 at enrollment Singleton pregnancy Non-smoking Residence at study site since 12 months or longer

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 44 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Lebanese pregnant women<br>Pregnant women which are suspected to have mild to moderate iodine deficiency but are otherwise health and living in the Lebanon. | Other: no intervention<br>* this is a completely observational study, NO INTERVENTION<br>|
| Thai pregnant women<br>Pregnant women which are suspected to have mild to moderate iodine deficiency but are otherwise health and living in Thailand. | Other: no intervention<br>* this is a completely observational study, NO INTERVENTION<br>|
| South African pregnant women<br>Pregnant women which are suspected to have mild to moderate iodine deficiency but are otherwise health and living in South Africa. | Other: no intervention<br>* this is a completely observational study, NO INTERVENTION<br>|
| New Zealand pregnant women<br>Pregnant women which are suspected to have mild to moderate iodine deficiency but are otherwise health and living in New Zealand. | Other: no intervention<br>* this is a completely observational study, NO INTERVENTION<br>|
| Swedish Pregnant women<br>Pregnant women which are suspected to have mild to moderate iodine deficiency but are otherwise health and living in Sweden. | Other: no intervention<br>* this is a completely observational study, NO INTERVENTION<br>|
| Peruvian pregnant women<br>Pregnant women which are suspected to have mild to moderate iodine deficiency but are otherwise health and living in Peru. | Other: no intervention<br>* this is a completely observational study, NO INTERVENTION<br>|
| Russian pregnant women<br>Pregnant women which are suspected to have mild to moderate iodine deficiency but are otherwise health and living in Russia. | Other: no intervention<br>* this is a completely observational study, NO INTERVENTION<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Urinary iodine concentration and Thyroglobulin concentration in pregnant women. | Analysis of urine and blood samples to find urinary iodine concentration and Thyroglobulin concentration of each participant. | June 2018 |