linjc16/ctgov huggingface dataset:
Reverse Total Shoulder Arthroplasty Versus Open Reduction Internal Fixation of 3&4 Part Proximal Humerus Fractures

Study Overview
=================
Brief Summary
-----------------
Will patients who suffer complex humerus fractures have better functional outcomes and less implant failure with shoulder replacement (reverse total shoulder arthroplasty, RTSA) compared to shoulder repair (open reduction and internal fixation, ORIF)?

Detailed Description
-----------------
The purpose of this study is to compare validated clinical and functional outcomes between patients who acutely present with 3 and 4-part proximal humerus fractures treated with either ORIF or RTSA.

Official Title
-----------------
Reverse Total Shoulder Arthroplasty Versus Open Reduction Internal Fixation of 3 &Amp; 4-Part Proximal Humerus Fractures: A Randomized Prospective Study

Conditions
-----------------
Closed Fracture Proximal Humerus, Four Part

Intervention / Treatment
-----------------
* Procedure: Fracture repair
* Procedure: Fracture repair with joint replacement


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Neer 3 and 4-part proximal humerus fractures. Age greater than and equal to 70 years old. Functional deltoid musculature (axillary nerve intact). Exclusion Less than 70 years old. Dementia or inability to provide adequate follow up. Associated injuries: injuries of ipsilateral limb, complete brachial plexopathy, vascular injury and polytrauma.

Ages Eligible for Study
-----------------
Minimum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Open Reduction Internal Fixation Proximal Humerus<br>The patients randomized into the ORIF group will receive standard surgical treatment of their proximal humerus fracture with a proximal humeral locking plate. | Procedure: Fracture repair<br> <br> |
| Active Comparator: Reverse Total Shoulder Arthroplasty<br>The patients randomized into the RTSA group will receive standard surgical treatment of their proximal humeral fracture with a Reverse Total Shoulder Arthroplasty. | Procedure: Fracture repair with joint replacement<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To measure the change using the chi-square tests for lowering the pain score of the patients | threshold of statistical significance will be set at α = 0.05. | base line to 2 years |
Effectiveness of Using 3D Printed Models to Educate Otolaryngology (Ear, Nose, Nose and Throat (ENT)) Patients About Surgery: A Survey

Study Overview
=================
Brief Summary
-----------------
Within the Ear, Nose, and Throat (ENT) medical space, a relatively small number of patients follow through with elective surgeries to fix ailments like a deviated septum or occluded sinus passage. Patient understanding of their diagnosis and treatment plan is integral to compliance, which ultimately yields improved medical outcomes and better quality of life. Here the investigators report the usage of advanced inkjet 3D printing methods to develop a multimaterial replica of the patient's nasal sinus anatomy, derived from clinical X-ray Computed Tomography (CT) data. The final patient education model was developed over several iterations to optimize material properties, anatomical accuracy and overall display. A two arm, single center, randomized, prospective study was then performed in which 50 ENT surgical candidates (and an associated control group, n = 50) were given an explanation of their anatomy, disease state, and treatment options using the education model as an aid. Each patient was then surveyed for their self-rated understanding of their anatomy, disease, and treatment options.

Official Title
-----------------
The Effectiveness of Using 3D Printed Anatomically Accurate Models to Educate Patients About Surgery: A Survey

Conditions
-----------------
Pathological Conditions, Anatomical, Deviated Nasal Septum

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male and female subjects that are 18 years or older. Surgeon must have recommended nasal or sinus surgery Not excluded as a surgical candidate Exclusion Criteria: Patients who or not able to read or understand English

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Control, no anatomical model used for description | |
| 2<br>Anatomical model used for description | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Question: How did the doctor's visualization help you in your understanding of the surgery? |  | 1 year |
Complementary And Alternative Medicine During The COVID-19 Pandemic

Study Overview
=================
Brief Summary
-----------------
Complementary and alternative medicine is frequently used in the treatment of several groups of diseases.

Detailed Description
-----------------
This study aimed to explore the attitudes of adults living in Turkey toward complementary and alternative medicine in the period of the COVID-19 pandemic and identify whether Turkish adults used it during the pandemic.

Official Title
-----------------
Adults' Attitudes Toward Complementary And Alternative Medicine And Their State Of Using Complementary And Alternative Medicine During The COVID-19 Pandemic

Conditions
-----------------
Complementary Therapies

Intervention / Treatment
-----------------
* Other: Complementary And Alternative Medicine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: agree to participate in the study not to be a communication problem Exclusion Criteria: be a communication problem

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Complementary And Alternative Medicine|No intervention was done in the cross-sectional study|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Participant adults' responses to the questions raised about the use of complementary and alternative methods during the COVID-19 pandemic |  | 2021 | 
| Means of scores obtained by participant adults from the holistic complementary and alternative medicine questionnaire (HCAMQ) and its sub-scales | Holistic Complementary and Alternative Medicine Questionnaire | 2021 | 
| Complementary and alternative treatment methods used during the COVID-19 pandemic |  | 2021 | 
| Plants consumed during the COVID-19 pandemic |  | 2021 | 
| Symptoms against which complementary and alternative methods are used during the COVID-19 pandemic |  | 2021 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Attitude, Complementary Therapies, COVID-19, Complementary and Alternative Medicine
The Utility of Performing Brain CT Scan in Non Trauma Patients at the Pediatric Emergency Unit

Study Overview
=================
Brief Summary
-----------------
Pediatric patients are admitted to the emergency room for diverse causes, beside trauma, patients can present with convulsions, suspicion of brain tumor or increased intracranial pressure. In most of the cases a brain CT is performed even before physical examination by a skilled neurologist. The amount of radiation that the children are exposed is equivalent to 100 plain chest X rays. The purpose of this tudy is to examinate in a retrospective study what were the indications for CT study and what was the incidence of relevant abnormal findings that required emergency intervention or referral.

Official Title
-----------------
The Utility of Performing Brain CT Scan in Non Trauma Patients at the Pediatric Emergency Unit. A Retrospective Observational Study.

Conditions
-----------------
Convulsions, Increased Intracraneal Pressure

Intervention / Treatment
-----------------
* Procedure: Medical history
* Procedure: Brain CT scan


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients in the pediatric age that underwent brain CT scan in the pediatric emergency room Exclusion Criteria: Patients with recent history of trauma

Ages Eligible for Study
-----------------
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Medical history|nan|
|Procedure: Brain CT scan|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Brain CT scan, Pediatric emergency room
The Long-term Effects of Training on Muscle Strength and Functionality

Study Overview
=================
Brief Summary
-----------------
The purpose of the present study is to evaluate the long-term effects of 1 year of high-intensity fitness training and low-intensity whole-body vibration training on muscle strength and functionality. Therefore, muscle strength and functionality are measured after a 6-yr interval in older adults (65+).

Conditions
-----------------
Training, Ageing, Muscle Strength, Functionality

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: female (+65 years) participation in previous study De effecten van oefenprogramma's op gezondheids- en fitheidsgerelateerde parameters in een groep van 60-plussers [The effects of exercise programs on health and fitness-related parameters in a group of people over 60] able to perform a maximal strength test on a dynamometer Exclusion Criteria: - pathologies that prohibit a maximal strength test on a dynamometer

Ages Eligible for Study
-----------------
Minimum Age: 65 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Fitness<br> | |
| Whole-body vibration<br> | |
| Control<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Phase II Trial of Sunitinib in BAC or Never-Smokers With Any Lung Adenocarcinoma

Study Overview
=================
Brief Summary
-----------------
This is an open-label study of a new oral drug for advanced stage (IIIB or IV) lung cancer. The cancer must be EITHER bronchoalveolar carcinoma (BAC) type, or if the patient is a never-smoker (less than 100 cigarettes lifetime) the cancer can be any type of adenocarcinoma.

Detailed Description
-----------------
To participate in this study, patients must have disease that can be measured on a CT scan. Brain metastases are OK if stable. Pregnant and/or nursing women may not participate. This drug has been approved by the FDA for the treatment of advanced renal cell cancer and a certain type of stomach/intestinal cancer. Its efficacy in lung cancer in currently unknown. Common side effects include fatigue, nausea, diarrhea, skin reaction, and decreased blood counts.

Official Title
-----------------
Phase II Trial of Sunitinib in Bronchoalveolar Carcinoma or Never-Smokers With Any Lung Adenocarcinoma

Conditions
-----------------
Lung Cancer, Adenocarcinoma

Intervention / Treatment
-----------------
* Drug: sunitinib


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Bronchoalveolar carcinoma with disease measurable on CAT scan Any lung adenocarcinoma in a never-smoker (less than 100 cigarettes lifetime) with disease measurable on CAT scan Stage IIIB or IV Exclusion Criteria: Uncontrolled hypertension Unstable brain metastases Pregnant/nursing women Uncontrolled thyroid disease

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: sunitinib|50mg po qd x 4 weeks on followed by 2 weeks off for a 6 week cycle.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression-Free Survival |  | January 2009 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
bronchoalveolar carcinoma, BAC, adenocarcinoma, lung cancer, oral, Stage IIIB and IV lung cancer, Any bronchoalveolar carcinoma (BAC), Any adenocarcinoma in a never-smoker
HuMax-CD4 in Non-Cutaneous T-Cell Lymphoma

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to assess the safety and efficacy of treatment of non-cutaneous T-cell lymphoma with treatment with CD4.

Detailed Description
-----------------
The study is closed and all subjects have completed treatment. The study is to evaluate the safety and efficacy of Humax CD4 with CHO vs CHO alone in subjects with non-cutaneous T cell lymphoma. The primary efficacy will be evaluated by time to relapse.

Official Title
-----------------
An Open-Label Therapeutic Exploratory Clinical Trial of HuMax-CD4, a Fully Human Monoclonal Anti-CD4 Antibody, in Patients With Refractory or Relapsed Non-Cutaneous CD4+ T-Cell Lymphoma

Conditions
-----------------
T Cell Lymphoma

Intervention / Treatment
-----------------
* Biological: HuMax-CD4


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnostic biopsy of non cutaneous T Cell lymphoma with positive phenotype Relapsed or refractory to minimum of one course of chemotherapy Study is closed to enrollment.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: CD4<br>Open label treatment arm | Biological: HuMax-CD4<br>* Active treatment<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Efficacy as measured by survival and time to disease progression |  | 12 months |
Clinical Research on Effectiveness and Safety of Treatment of Severe Oligospermia or Azoospermia With uFSH

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine whether uFSH is effective and safe in the treatment of male patients with severe oligospermia or azoospermia.

Official Title
-----------------
Effectiveness and Safety of uFSH for Severe Oligospermia or Azoospermia:A Multi-center,Open,Randomized,Interventional,and Phase4 Trial in China

Conditions
-----------------
Oligospermia, Azoospermia

Intervention / Treatment
-----------------
* Drug: 75IU uFSH


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male subjects aged 20 35. They accorded with diagnostic criteria of severe oligospermia or azoospermia. They had'nt been treated with drug which could improve sperm count and quality one month before observation，otherwise,they should have a elution for 1 month before the study. Exclusion Criteria: Gram-positive bacteria ,Chlamydia trachomatis,Ureaplasmaurealyticum,or mycoplasma hominis were detected in their semen. Subjects addicted to drug，tobacco，or alcohol. Subjects had heat,chemicals,radioactive material,or toxic contact history within a year. Subjects were under treatment of gonadotropin,anabolic steroid,chemotherapeutic drugs,or nonsteroidal anti-inflammatory drugs . Subjects combined with cardiovascular, liver, kidney ,or hematopoietic system severe primary disease,or mental disease. Subjects were allergic or on uFSH allergy,or under the treatment of other drugs for infertility . Subjects did not meet the inclusion criteria, did not according to the prescribed medication, were unable to judge the efficacy ,had incomplete information, or affected the efficacy or safety judgment. Subjects were IHH patients

Ages Eligible for Study
-----------------
Minimum Age: 25 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 75IU uFSH<br>75IU uFSH (Livzon Pharm Group Inc., China) being injected into severe oligospermia patients or azoospermia patients every 3 days for 6 months | Drug: 75IU uFSH<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sperm density |  | 6 month | 
| (A + B)grade sperm and sperm activity rate |  | 6 month | 
| A grade sperm |  | 6 month | 
| semen volume |  | 6 month | 
| sex hormone levels |  | 6 month | 
| testis volume |  | 6 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
infertility
Retrospective Analysis of Surgical Outcomes After Corneal Transplantation

Study Overview
=================
Brief Summary
-----------------
Currently, no demographic and surgical results comparing different donor cornea sources were available in Taiwan. National Taiwan University Hospital (NTUH), as one of the largest tertiary medical centers in northern Taiwan, is now in charge of a big part of intense care for patients receiving corneal transplantation. With detailed medical record done of these patients during care in the ward and out-patient clinic, the investigators are competence for this meaningful program.

Detailed Description
-----------------
An insufficient donor supply is a worldwide problem in organ transplantation. Even with corneal transplantations, the most widely performed transplantation, shortages and imbalances in donor supply is a global concern. In National Taiwan University Hospital (NTUH), the investigators performed over one hundred of corneal transplantations every year and the majority of donor corneas were from the eye bank in United States. Previous literature showed satisfactory results in corneal transplantation using foreign donor corneas compared with domestic corneas. However longer preservation time had associated with a statistically significant increased risk of persistence of the postoperative epithelial defect. On the other hand, longer storage times may allow better outcomes in high-risk grafts because of the depletion of donor T cells from the donor cornea into the storage media. Currently, no demographic and surgical results comparing different donor cornea sources were available in Taiwan. NTUH, as one of the largest tertiary medical centers in northern Taiwan, is now in charge of a big part of intense care for patients receiving corneal transplantation. With detailed medical record done of these patients during care in the ward and out-patient clinic, the investigators are competence for this meaningful program.

Official Title
-----------------
Retrospective Analysis of Surgical Outcomes After Corneal Transplantation

Conditions
-----------------
Corneal Transplantation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The patients who received corneal transplantation within full chart records Exclusion Criteria: The patients have cognitive Impairment. No detail or unclear ophthalmologic record. Patients or their legal representative have no willing to accept this tracing study.

Ages Eligible for Study
-----------------
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
surgical outcomes after corneal transplantation, Retrospective analysis, corneal transplantation