Effect of Different Liquids Intake in Vasovagal Reaction After Whole Blood Donation

Study Overview
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Brief Summary
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we compared the effect of 3 different kinds of liquids (water, Oral Rehydration Salt 3 and white granulated sugar water) intake in Vasovagal Reaction After Whole Blood Donation

Detailed Description
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Vasovagal reaction is the most common type of blood donation reaction. The main cause of this reaction is the decrease of blood volume. Therefore, fluid supplement before blood donation has been proved to be effective in preventing the vagal reaction after blood donation. It was proved that isotonic (sugar & salt) drink intake before blood donation had a significant effect on reducing vasovagal reaction. However, in 2002, WHO recommended the new reduced osmolarity rehydration formula with better taste. Oral Rehydration Salt 3 has been produced according to WHO formula with standard ingredient and easy to prepare. In addition, in Guangdong culture, sugar water is regarded as a tonic, more easily accepted. So, the aim of our study was to compare the effects of 500 ml water with Oral Rehydration Salt 3, white granulated sugar and conventional recommended water intake prior to blood donation on blood donation reaction after whole blood donation, in order to understand the effect of different liquid supplement on blood donation reaction and the willingness of blood donation again.

Official Title
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Effect of Different Liquids Intake in Vasovagal Reaction After Whole Blood Donation

Conditions
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Blood Donation

Intervention / Treatment
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* Drug: Oral Rehydration Salts power (iii)
* Dietary Supplement: water with white granulated sugar
* Dietary Supplement: water


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria:All blood donors donated whole blood in Guangzhou Blood Center during study. - Exclusion Criteria:Blood donors who were deferral by blood screening result and other situations. -

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Oral Rehydration Salts Power (iii)<br>Dissolve 2 packs of Oral Rehydration Salts Power (iii) (5.125g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation. | Drug: Oral Rehydration Salts power (iii)<br>* Dissolve 2 packs of Oral Rehydration Salts Power (iii) (5.125g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.<br>* Other names: Sichuan Emeishan Pharmaceutical Co., Ltd. 20210402 5100621103491;|
| Experimental: water with white granulated sugar<br>Dissolve 2 packs of Taikoo white granulated sugar (5g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation. | Dietary Supplement: water with white granulated sugar<br>* Dissolve 2 packs of Taikoo white granulated sugar (5g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.<br>|
| Placebo Comparator: recommended water intake<br>Recommend the subjects to drink up 500ml water in 20 minutes prior to donation. | Dietary Supplement: water<br>* Recommend the subjects to drink up 500ml water in 20 minutes prior to donation.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| vasovagal reaction rate | vasovagal reaction rate in three groups | 1-3days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rate of willingness to donate blood again | rate of willingness to donate blood again in three groups | 3days |