The Effective Treatment of Oral Helicobacter Pylori With the Success Rate of Gastric Eradication

Study Overview
=================
Brief Summary
-----------------
Gastric eradication has no effective on oral H. pylori infection. Treatment of oral infection increase success rate of eradication on stomach infection.

Detailed Description
-----------------
Objective: The present study was aimed to explore the relationship of Helicobacter pylori(H. pylori) of the oral cavity with the success rate eradication of gastric H. pylori infection. Study Design and Setting: 202 symptomatic and 148 asymptomatic individuals were recruited and tested using Saliva H. pylori antigen tests (HPS), H. pylori flagellin (HPF), the urea breathe test (UBT) and the polymerase chain reaction (PCR) test. Test subjects also received various treatments. We collected data of HPS, HPF , PCR and UBT before treatment on 202 symptomatic patients and 148 asymptomatic individual groups. After drug treatment, we run HPS, HPF, PCR and UBT tests. If the tests of HPS, HPF and PCR show negative that indicate success of oral H.pylori eradication. If the test of UBT show negative that indicate success of stomach H.pyloi eradication. We also compare the suceess rate of eradication on stomach infection with and without oral H. pylori infection.

Official Title
-----------------
Director of Research Division

Conditions
-----------------
Oral Helicobacter Pylori

Intervention / Treatment
-----------------
* Drug: Amoxicillin and Tetracyclines
* Drug: Mouth washing


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with gastrointestinal complaints Exclusion Criteria: patients who had taken any antibiotics and/or proton pump inhibitors within four weeks prior to sample collection
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Amoxicillin and Tetracyclines<br>drug treatment | Drug: Amoxicillin and Tetracyclines<br>* 202 symptomatic and 148 asymptomatic individuals were recruited and tested using Saliva H. pylori antigen tests (HPS), H. pylori flagellin (HPF), the urea breathe test (UBT) and the polymerase chain reaction (PCR) test. Test subjects also received various treatments.<br>* Other names: dBest;|
| Other: Mouth washing<br>Mouth washing | Drug: Mouth washing<br>* Two time washing mouth per day<br>* Other names: dBest;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Success Rate |  | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnostic |  | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Symptomatic patients, asymptomatic individuals, clinical trial