Ultrasound to Evaluate the Quadriceps Muscle Wasting

Study Overview
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Brief Summary
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Intensive care unit acquired muscle weakness (ICUAW) is a common disease. After 7 days of mechanical ventilation, a quarter of patients develop an ICUAW responsible of a 15-20% of muscle loss. This is a serious pathology associated with high morbidity and mortality. Clinical diagnosis of ICUAW is difficult and need a patient awoken. CT scan and Magnetic Resonance Imaging (MRI) are considered as gold standards to quantify and monitor changes in muscle mass. But these tools are not adapted to ICU patients. Ultrasound (US) is an easy access tool at the bedside to assess muscle mass and does not expose the patient to additional radiation. The objective of this study is to evaluate the correlation between US and CT scan to measure quadriceps muscle thickness of ICU patients.

Detailed Description
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As part of the monitoring of the neurological disease, brain CT scans are frequently performed. At the same time, an acquisition sequence centered on the quadriceps will follow the brain sequences. Up to three brain CT scans coupled with a quadriceps imaging will be performed between the day of admission and on the tenth day of hospitalization. An ultrasound of the quadriceps will be performed concomitantly. The thickness of the quadriceps is measured by an independent operator on CT and ultrasound images.

Official Title
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Interest of the Ultrasound to Evaluate the Quadriceps Muscle Wasting in Critical Ill Patients.

Conditions
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Severe Cerebral Pathology

Intervention / Treatment
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* Device: CT Scan and ultrasonography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient over 18 years admitted to intensive care for a severe brain injury (Glasgow <8) and with a predictive duration of mechanical of at least 48hours Exclusion Criteria: Pregnancy, Bilateral trauma of thighs, Coma induced by poisoning or by a metabolic disorder, Morbid obesity (BMI > 35).

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: CT scan and Ultrasonography<br>Up to three measurements (CT scan and Ultrasonography), will be made concurrently between the day of admission (D1) in intensive care unit and the tenth day ( D10 ) . | Device: CT Scan and ultrasonography<br>* Up to three measurements (CT scan and Ultrasonography) of the thickness of quadriceps, will be made concurrently .<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Concordance of the measurement of the quadriceps thickness by ultrasound and by CT scan | Concordance of each of the three measurements of the thickness of quadriceps realised concurrently by CT scan and Ultrasonography (composite measure) | Between the day of admission (D1) in intensive care unit and the tenth day ( D10 ) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| kinetic of the thickness of quadriceps | Evolution of he thickness of quadriceps measure concurrently by CT scan and Ultrasonography | Between the day of admission (D1) in intensive care unit and the tenth day ( D10 ) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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severe cerebral pathology, Ultrasound, thickness of the quadriceps