Altered Vestibular Perception and Transcranial Magnetic Stimulation

Study Overview
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Brief Summary
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The long-term goal of this research is to advance our knowledge of how information from the labyrinth is brought to perception and how adaptation to vestibular imbalance influences motion sensation. Patients with vestibular disorders frequently have disabling disturbances of perception. Related to these symptoms is that large areas of the cerebral hemispheres and the cerebellum receive information from the vestibular, visual and somatosensory systems that is integrated within a vestibular cortical network into an accurate perception of spatial orientation. Interrupting the pathways that process information about the direction of gravity and angular velocity leads to impairment of the internal estimate of gravity and the perception of body motion. The strategy of this research is to use repetitive transcranial magnetic stimulation (rTMS) to produce transient focal lesions that allow study of acute loss of function within the central vestibular pathways at the very beginning of adaptation. Our underlying hypothesis is that the immediate effects of a lesion in the cerebellum will be to affect ocular motor control of vestibular reflexes and perception alike but with a cortical lesion there will be dissociation between ocular motor control and perception. This research helps to understand the mechanisms involved in the perception of vestibular information and the cerebellar influence on processing vestibular input and offers a unique opportunity to make major inroads into the understanding and eventually treatment of the often incapacitating symptoms of patients with vestibular disease

Official Title
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Altered Vestibular Perception by Virtual Lesions of Cerebral and Cerebellar Structures Using Repetitive Transcranial Magnetic Stimulation - Implications for Human Vestibular Dysfunction

Conditions
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Verticality Perception, Self-motion Perception

Intervention / Treatment
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* Other: transcranial magnetic stimulation and motion stimuli


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ages 18-70 informed consent Exclusion Criteria: disturbed consciousness other neurological or systemic disorder which can cause dementia or cognitive dysfunction prior history of a major psychiatric disorder history of definite stroke focal lesion on MRI exam use of anxiolytic, antidepressant, neuroleptic or sedative medication has MRI contraindication such as pacemaker, implanted pumps, shrapnel, etc. (full MRI screening form will be filled out). History of seizure or a family history of epilepsy; increased intracranial pressure, such as after infarctions or trauma pregnancy or possibility of being pregnant unless precluded by a negative pregnancy test history of any significant head trauma.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: TMS<br> | Other: transcranial magnetic stimulation and motion stimuli<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes in verticality perception and self-motion perception after TMS (transcranial magnetic stimulation) |  | within 30min after TMS | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| vestibulo-ocular reflex after TMS (transcranial magnetic stimulation) |  | within 30min after TMS |