A Feasibility Trial and Protocol for Remote Cognitive Training Developed for Use in a Cognitively Healthy Adult Population During the COVID-19 Pandemic

Study Overview
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Brief Summary
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The COVID-19 pandemic has created a shift in the use of at-home spaces for work, play and research. In the current study, the feasibility of implementing an at-home cognitive training tool called NeuroTrackerX, an anaglyph version of the three-dimensional multiple object tracking (3D-MOT) software NeuroTracker was examined, and with the intent of developing an effective protocol and determining the suitability of this tool for research purposes .

Detailed Description
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The work looks at the feasibility of using a newly developed anaglyph 3D cognitive training tool called NeuroTrackerX in research with adult participants. The work looks to validate an at-home program by comparing participants who complete an online version of Neurotracker (NeurotrackerX) with a group of individuals who completed the classically used in-lab version (Neurotracker). Due to COVID-19, many laboratories forced to transition to remote-based studies, and the purpose of the work is to validate the remote-based protocol. Twenty cognitively healthy adults (10 Male; 10 female) were recruited to engage in this at-home program. The results of these individuals will be compared with results from a group of cognitively healthy adults who had previously engaged in the in-lab version of the program prior to the pandemic.

Official Title
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A Feasibility Trial and Protocol for Remote Cognitive Training Developed for Use in a Cognitively Healthy Adult Population During the COVID-19 Pandemic

Conditions
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Cognition Disorders in Old Age

Intervention / Treatment
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* Device: NeurotrackerX


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Inclusion criteria for both groups included being aged 50 years and older and to have either normal or corrected vision. Exclusion Criteria: Exclusion criteria included the presence of any major neurocognitive disorder or the presence of visual deficits that impeded one's ability to complete the 3D task.

Ages Eligible for Study
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Minimum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Interventional Model Description: Twenty adults (10 female, 10 male) will serve as the at-home training group. The cognitive health status for participants will be assessed using a self-report questionnaire and the Mini-Mental State Examination (MMSE), and all participants were deemed cognitively healthy (MMSE > 26). At-home participants loaned the necessary equipment (e.g., 3D-glasses, computer equipment) from the research facilities and engaged in 10 training sessions over five weeks (2x per week). Participant recruitment, retention, adherence and experience will be used as markers of feasibility. For program validation, twenty participants above 50 years old, who had previously completed at least eight sessions of the in-lab 3D-MOT program, were randomly selected as the control group. Individual session scores, overall improvement and learning rates between groups will be compared.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: At home cognitive training<br>We recruited 20 adults (10 female, mean age = 68.3 years, SD = 6.75) as the at-home training group. We assessed cognitive health status for participants using a self-report questionnaire and the Mini-Mental State Examination (MMSE), and all participants were deemed cognitively healthy (MMSE > 26). At-home participants loaned the necessary equipment (e.g., 3D-glasses, computer equipment) from the research facilities and engaged in 10 training sessions over five weeks (2x per week). Participant recruitment, retention, adherence and experience were used as markers of feasibility. | Device: NeurotrackerX<br>* At-home participants loaned the necessary equipment (e.g., 3D-glasses, computer equipment) from the research facilities and engaged in 10 training sessions over five weeks (2x per week). Participant recruitment, retention, adherence and experience were used as markers of feasibility. For program validation, twenty participants above 50 years old, who had previously completed at least eight sessions of the in-lab 3D-MOT program, were randomly selected as the control group.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neurotracker scores | Performance on the multiple-object tracking program across 10 sessions. Scores are between 0 - 4, with increasing scores indicating increasing performance. | 5 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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3-dimensional multiple object tracking, Cognitive Training, Neurotracker