Portsmouth CORE-D Routine Care Data Repository

Study Overview
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Brief Summary
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An integrated database of depersonalised routine hospital patient data consisting of demographic and disease attributes, physiological or laboratory measurements, care contacts and interventions along with associated clinical outcomes. The database is an essential resource for the development and testing of risk models and classification systems, modified as necessary for patient subgroups, which can then be introduced into clinical care to improve patient outcomes. It can also be used for large scale simulations to evaluate interventions.

Detailed Description
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The aims and objectives of this database of depersonalised routinely collected hospital patient data are to: Conduct epidemiological and observational studies of acute hospital care. Develop and use algorithms and risk models to identify the deteriorating / sick adult so that interventions and enhanced care can be provided in a timelier manner with consequent resource and outcome improvements. This covers both the deteriorating inpatient at risk of adverse outcomes and people in the local community at risk of hospitalisation or in need of other health services. Retrospectively evaluate interventions e.g. impact of system-wide clinical pathway introduction Conduct simulations of clinical pathways

Official Title
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Portsmouth Clinical Outcomes REsearch Database (CORE-D)- a Research Database of Routine Electronically Recorded Patient Data to Model Adverse Clinical Outcomes and Healthcare Resource Usage

Conditions
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Adult Hospital Patients at Risk of Adverse Outcomes

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult presenting at the acute hospital or receiving services from the hospital Exclusion Criteria: Adults who have registered an opt out of research with National Health Service (NHS) Digital Adults who have contacted the hospital to ask that their records are not to be included in this study

Ages Eligible for Study
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Minimum Age: 16 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| In-hospital death | Death during hospital admission | At 24 hours after an observation assessment or physiological measurement | 
| In-hospital death | Death during hospital admission | 30 days after admission | 
| Unanticipated ICU admission | Unanticipated ICU admission during hospital stay | At 24 hours after an observation assessment or physiological measurement | 
| Unanticipated ICU admission | Unanticipated ICU admission during hospital stay | 30 days after admission | 
| Cardiac arrest | Cardiac arrest during hospital stay | At 24 hours after an observation assessment or physiological measurement | 
| Cardiac arrest | Cardiac arrest during hospital stay | 30 days after admission | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnosis of Corona Virus Disease (COVID) infection | Diagnosis of COVID-19 | 48 hours after presentation | 
| Diagnosis of Corona Virus Disease (COVID) infection | Diagnosis of COVID-19 | At 48 hours after an observation assessment or physiological measurement | 
| Detection of Acute Organ Dysfunction | Detection of acute organ dysfunction as measured by components of the Sequential Organ Failure Assessment (SOFA) Score | 24 hours after presentation | 
| Detection of Acute Organ Dysfunction | Detection of acute organ dysfunction as measured by components of the Sequential Organ Failure Assessment (SOFA) Score | 48 hours after presentation | 
| Detection of Acute Organ Dysfunction | Detection of acute organ dysfunction as measured by components of the Sequential Organ Failure Assessment (SOFA) Score | 72 hours after presentation | 
| Detection of Acute Organ Dysfunction | Detection of acute organ dysfunction as measured by components of the Sequential Organ Failure Assessment (SOFA) Score | 1 week after presentation | 
| Detection of Acute Organ Dysfunction | Detection of acute organ dysfunction as measured by components of the Sequential Organ Failure Assessment (SOFA) Score | 30 days after presentation |