Quantification of Abdominal Organ Motion Using MRI

Study Overview
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Brief Summary
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The primary aim of the study is to quantify abdominal motion in order to optimise MR imaging. The study will compare three-motion management strategies a) free-breathing, b) using an abdominal compression belt and c) using MRI-compatible visually guided breath-holds.

Official Title
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Quantification of Abdominal Organ Motion Using Magnetic Resonance Imaging (MRI)

Conditions
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Cancer

Intervention / Treatment
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* Device: Compression belt
* Other: Visual Guided Breath-hold


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy volunteers 18 years or older, no MRI contra-indications must agree to registration as a non-patient in CWP (the local electronic healthcare records system) and have their MRIs read and reviewed for incidental findings by a clinical radiologist Patient Volunteers undergoing radiotherapy to the abdominal region at the Christie NHS Foundation Trust Over 18 years of age Exclusion Criteria: Any contraindications to MRI identified after MRI safety screening including completion of an MRI Safety Screening Form Unable to tolerate MRI scan Pregnancy Colostomy

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Free-breathing versus Compression<br>This cohort of volunteers and patients will undergo imaging on the MR-Linac investigating free-breathing motion, and comparing it to motion using an abdominal compression device. | Device: Compression belt<br>* The abdominal belt is fastened around the lower abdomen and inflated (like an inner tube) to apply pressure to the belly and reduce the motion associated with respiration (breathing)<br>|
| Free-breathing versus Breath-holding<br>This cohort of volunteers and patients will undergo imaging on the MRSim investigating free-breathing motion and comparing it to visually-guided breath-hold motion (and reproducibility). | Other: Visual Guided Breath-hold<br>* A small tracer will be place on the lower abdomen that will feedback to a computer screen that will have graphics to show you if the participant is in breath-hold or not.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MRI Motion Management SOP | Development and implementation of an MRI protocol suitable for organ motion characterisation for the abdomen. Determination of the benefit of motion management strategies for abdominal radiotherapy. | through study completion, approximately 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quantification of motion | Quantification of intra-abdominal inter and intra-fraction motion with and without abdominal compression and visually guided breath holds using MR imaging. Comparative analysis of comparable treatment plans with and without abdominal compression and visually guided breath holds on relevant treatment planning software for PBT and MRL. Development of process to evaluate patient compliance when using a commercial available abdominal compression belt and visually guided breath-hold. | through study completion, approximately 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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MRI