The Effects of Sevoflurane and Desflurane on QT Interval Measured With Cardiac Electrophysiological Balance Index

Study Overview
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Brief Summary
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The primary aim of this study is to compare the effects of sevoflurane and desflurane on the QT interval. The secondary aim of this study is to compare the effects of drugs used in the induction and maintenance of anesthesia on the QT interval by calculating the Bazzet formula and iCEB.

Official Title
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A Prospective Randomized Comparison of the Effects of Sevoflurane and Desflurane Anesthesia on QT Interval Measured With Cardiac Electrophysiological Balance Index

Conditions
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Sevoflurane, Desflurane, QT Interval, Electrophysiological Balance Index

Intervention / Treatment
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* Diagnostic Test: 12- derivation Electrocardiography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA I-II-III risk group the operation time is longer than 1 hour in the Urology department. Exclusion Criteria: bundle branch block in preoperative ECG, Non-sinus heart rhythm, QT length in preoperative ECG, using drugs that cause known QT prolongation ( beta-blocker drugs using will be included), development of malignant arrhythmia that will disrupt hemodynamics in the intraoperative period, patients with electrolyte disorders, patient refusal -

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: sevoflurane<br>General Anesthesia procedure with sevoflurane | Diagnostic Test: 12- derivation Electrocardiography<br>* 6 precordial and 4 extremity electrodes will be placed at appropriate anatomical points and a total of 6 12-lead ECGs will be taken at different anesthesia depths before anesthesia induction and throughout the operation.<br>|
| Active Comparator: desflurane<br>General Anesthesia procedure with desflurane | Diagnostic Test: 12- derivation Electrocardiography<br>* 6 precordial and 4 extremity electrodes will be placed at appropriate anatomical points and a total of 6 12-lead ECGs will be taken at different anesthesia depths before anesthesia induction and throughout the operation.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| QTc T0 | QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR). | Baseline, preoperative | 
| QTc T1 | QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR). | During surgery (at the time of the anesthesia induction) | 
| QTc T2 | QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reaches 0,6, it will be calculated from the ECG. | During surgery (at the time of MAC reached 0,6) | 
| QTc T3 | QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reaches 1, it will be calculated from the ECG. | During surgery (at the time of MAC reached1) | 
| QTc T4 | QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reaches 1,3 , it will be calculated from the ECG. | During surgery (at the time of MAC reached 1,3) | 
| QTc T5 | QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reduces 0,3, it will be calculated from the ECG. | During surgery (at the time of MAC reduced 0,3) | 
| iCEB T0 | Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) | Baseline, preoperative | 
| iCEB T1 | Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) | During surgery (at the time of the anesthesia induction) | 
| iCEB T2 | Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) the mac value reaches 0,6, it will be calculated from the ECG. | During surgery (at the time of MAC reached 0,6) | 
| iCEB T3 | Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) the mac value reaches 1, it will be calculated from the ECG. | During surgery (at the time of MAC reached 1) | 
| iCEB T4 | Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) the mac value reaches 1,3, it will be calculated from the ECG. | During surgery (at the time of MAC reached 1,3) | 
| iCEB T5 | Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) when the mac value reduces 0,3, it will be calculated from the ECG. | During surgery (at the time of MAC reduced 0,3) |