The Effect of Dual Tasking on Physical and Cognitive Functions in Patients With Parkinson Disease

Study Overview
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Brief Summary
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The ability of performing multi-tasking procedures is impaired in patients with Parkinson's disease. In this study, our goal was to detect the effects of dual-task training with treadmill training on walking and balance and to compare its effects on quality of life, cognitive functions and risk of fall, to treadmill training alone.

Official Title
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Effects of Dual Task Training And Treadmill Training on Physical and Cognitive Functions in Patients With Parkinson Disease

Conditions
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Parkinson Disease

Intervention / Treatment
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* Other: Dual task
* Other: Treadmill Training
* Other: Standard exercise programme


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The patients with Idiopathic Parkinson Disease on medication who has Hoehn-Yahr 1-3 Mini Mental Test score 20 and above Functional Ambulation Category 2 and above No changes in medication in last 3 months No rehabilitation programme in last 3 months Exclusion Criteria: Diagnosis of Parkinsonism other than Idiopathic Parkinson Disease Global aphasia Severe cognitive dysfunction Other neurologic/orthopedic diseases Limiting cardiovascular or pulmonary disease Visual impairment Hearing loss

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: In this prospective, randomized, controlled, double-blinded study the patients were randomized to three groups as; dual-task group, single-task group and control group. All of the patients were scheduled on standard exercise programme. The patients in dual-task group received treadmill training with cognitive tasks and the patients in single-task group received treadmill training alone in addition to standard exercise programme. The training was scheduled as 30 minute sessions under supervision of a specialist, three times in a week for four weeks.
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Dual task<br>Treadmill training + cognitive tasks + standard exercise programme | Other: Dual task<br>* The patients in the dual task group received cognitive tasks during treadmill training sessions.<br>Other: Treadmill Training<br>* Standard treadmill training<br>Other: Standard exercise programme<br>* Standard exercise programme for Parkinson Disease<br>|
| Active Comparator: Single task<br>Treadmill training + standard exercise programme | Other: Treadmill Training<br>* Standard treadmill training<br>Other: Standard exercise programme<br>* Standard exercise programme for Parkinson Disease<br>|
| Active Comparator: Control<br>Standard exercise programme | Other: Standard exercise programme<br>* Standard exercise programme for Parkinson Disease<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 10MWT | 10 Meter Walk Test on comfortable speed | 12 weeks | 
| 10MWT with cognitive tasks | 10 Meter Walk Test with cognitive tasks | 12 weeks | 
| MoCA | Montreal Cognitive Assessment | 12 weeks | 
| TUG | Timed Up and Go Test | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PDQ-39 | Parkinson Disease Questionnaire 39 | 12 weeks | 
| FES-I | To evaluate fear of falling, all patients filled the Falls Efficacy Scale-International (FES-I). A series of 16 questions assesses the respondent's fear of falling for a range of ADLs. Each question was rated on a four-point scale. | 12 weeks | 
| Stroop Test | Cognitive assessment for executive functions | 12 weeks | 
| FOGQ | Freezing of Gait Questionnaire | 12 weeks | 
| Falls Diary | Falls account | 4 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dual task, treadmill, cognitive rehabilitation