Bioavailability of Fish Oils: Emulsified Versus Capsular Triglyceride

Study Overview
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Brief Summary
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The primary objective of this investigation is to determine the relative percentage and rate of incorporation of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and total omega-3 (n-3) fatty acids after ingestion of 4 emulsified flavored triglyceride fish oil supplements versus an encapsulated triglyceride in defined plasma lipid pools. The primary endpoints to be evaluated include the fatty acid composition of plasma lipids before and after consumption of a single dose of emulsified triglyceride based fish oil and triglyceride of similar n-3 compositions in capsule form. The investigators will measure changes in plasma phospholipid, and chylomicron fatty acids.

Official Title
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Bioavailability of Fish Oils: Emulsified vs. Capsular Triglyceride

Conditions
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Healthy Adults

Intervention / Treatment
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* Dietary Supplement: Coromega Omega-3 Squeeze
* Dietary Supplement: Coromega Nectar
* Dietary Supplement: Barleans Swirl
* Dietary Supplement: Nordic Omega-3 Softgel


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy adults ages 18 to 60. Body mass index between 22 and 32 kg/m2. Medical history (interview) demonstrating good health. Nonsmoker. Consumption of a typical American diet with no unusual dietary habits. Willingness to comply with the study protocol. Low reported n-3 intake (<100 mg/d) on the Omega-3 Checklist Exclusion Criteria: Any active, uncontrolled medical problem. Consumption of essential fatty acid supplements within the past 6 months. Use of lipid lowering drugs. Fish consumption greater than 1 fish meal per week

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Coromega Omega-3 Squeeze<br>5.03 g | Dietary Supplement: Coromega Omega-3 Squeeze<br>* 660 mg EPA, 434 mg DHA<br>|
| Experimental: Coromega Nectar<br>12.22 g | Dietary Supplement: Coromega Nectar<br>* 660 mg EPA, 436 mg DHA<br>|
| Experimental: Barleans Swirl<br>17.45 g | Dietary Supplement: Barleans Swirl<br>* 660 mg EPA, 660 mg DHA<br>|
| Active Comparator: Nordic Omega-3 Softgel<br>4 softgels | Dietary Supplement: Nordic Omega-3 Softgel<br>* 660 mg EPA, 440 mg DHA<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Area under the curve for phospholipid fatty acids | Evaluation of the bioavailability of fatty acids from fish oil supplements | 48 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Area under the curve for chylomicron fatty acids | Evaluation of the bioavailability of fatty acids from fish oil supplements | 48 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Omega-3 fatty acids, Phospholipid fatty acids, chymlomicron fatty acids, Bioavailability fo fish oil supplements in healthy adults