Big Data Analysis of the Use of bIomarkers Concentration

Study Overview
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Brief Summary
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The investigators conducted a retrospective analysis of all measured concentrations performed in a large subset of laboratories located in the French Brittany from February 2010 the 17th to August 2015 the 30th, in adults over 20 years old. The investigators are aimed at studying physicians' use and eventually misuse of biomarkers dosage and the characteristics of a broad population based on some biomarkers concentrations.

Detailed Description
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The rUBIDIuM study is a retrospective analysis that included all tests (but not including DNA analysis or HIV tests) performed in a large subset of laboratories located in the French Brittany from February 2010 the 17th to August 2015 the 30th. The area of study covers most of the Ille-et-Vilaine and a part of the Côtes d'Armor department in Brittany. The respective surface of these departments is 6775 and 6878 km2. All labs belong to the Biorance Laboratory group (consortium of 33 labs, Biorance Laboratoires Réunis) and are equipped with Roche Diagnostics instruments (Elecsys2010® analyzer, Roche diagnostics, Meylan, France). The main objectives are to study physicians' use and eventually misuse of biomarkers dosage and the characteristics of this broad population based on some biomarkers concentrations. For all adult patients >20y that came to a participating lab during the study period, the investigators collected the following information: demographics data, data about the prescription (date of order, list of analysis recommended, the date of blood collection and analysis), about the prescribers and the results of the analyses. After a de-identifying process, data were aggregated. the initial analyses will 1) examine the biological tests (number, types…) ordered in a large cohort of patients, in the total population and the subgroups based on gender, age, time period, kind of lab and physicians' specialty, 2) examine the results/concentration of the analyses: blood chemistry, creatinin concentration, cardiac enzymes, natriuretic peptides, INR, lipid profile, hemogram…

Official Title
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Defining Use and Misuse of BIoMarkers Dosage and Trends in Observed Concentration Over Time: a BIg Data Analysis

Conditions
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Biological Markers, Inappropriate Prescribing

Intervention / Treatment
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* Diagnostic Test: Measured concentrations of biomarkers


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All adult patients >20 that came to a participating lab (Biorance Laboratoires Réunis) during the study period for biological measurement Exclusion Criteria: DNA analysis, HIV test

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Measured concentrations of biomarkers|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| biomarker dosage prescription | physicians' use and eventually misuse of biomarkers dosage | August 2017 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Biomarkers dosage numbers | Biomarkers dosage numbers before and after new treatments, released of guidelines, new tests... | August 2017 | 
| Biomarkers in geriatric patients | biomarkers dosages and concentration in elderly/very elderly patients | August 2017 | 
| Population's characteristics | physicians' use and eventually misuse of biomarkers dosage | August 2017 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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INR, Biological markers, Professional practice, Big data analysis, Measured concentrations, Cardiac markers, Troponin, NTproBNP, Creatinin, Hemogram, Lipid profile