Can Combination of Low-Level Laser and Light-Emitting Diodes Enhance Stability of Dental Implants?

Study Overview
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Brief Summary
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Subjects were assigned in two groups: In group 1, subjects received LLL and LED 20 min/day for 10 days after implant insertion, subjects in group 2did not undergo LLL and LED. implant stability quotients(ISQs) were measured in 0,10,21,42 and 63 days after implant placement.

Detailed Description
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Subjects eligible for study inclusion had an edentulous area at the first molar of the mandible and needed a dental implant. Subjects were excluded from study enrollment if they had any diseases that affect bone, smoking, insufficient bone in the edentulous area which needs bone augmentation, failed to return for follow-up, or refused study enrollment. All implants were placed at least 3 months after tooth removal. The size of implants was 4.8X 10 mm (Zimmer, USA) Subjects were aligned based on computer randomization in two groups: In group 1(intervention), subjects received LLL and LED after implant placement and in group 2 (control) the same device was used while device was off. A portable device was applied for irradiation of the intervention group with combination of 810nm laser and 632nm LED. Subjects in group 1 underwent LLL 15 mw/cm2 and LED 10 mw/cm2 20 min every day for 10 days. The mesiodistal and buccolingual directions were measured and the mean implant stability quotients (ISQs) were determined. The RFA measurements were performed in immediate after insertion (time0) 10 days (time1), 3 weeks (time2), 6 weeks(time3) and 9(time 4) weeks after implant placement.

Official Title
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Use Low-Level Laser and Light-Emitting Diodes in Dental Implants

Conditions
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Dental Implant Healing

Intervention / Treatment
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* Device: Low-Level Laser and Light-Emitting Diodes
* Device: Dental implant placement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: subjects eligible for study inclusion had an edentulous area at the first molar of the mandible and needed a dental implant Exclusion Criteria: . Subjects were excluded from study enrollment if they had any diseases that affect bone, smoking, insufficient bone in the edentulous area which needs bone augmentation, failed to return for follow-up, or refused study enrollment.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Subjects were aligned based on computer randomization in two groups: In group 1(intervention), subjects received LLL and LED after implant placement and in group 2 (control) the same device was used while device was off.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Laser Emitting group<br>subjects received Low-Level Laser and Light-Emitting Diodes after implant placement | Device: Low-Level Laser and Light-Emitting Diodes<br>* Combination of Low-Level Laser and Light-Emitting Diodes were used after dental implant placement for enhancement of stability<br>Device: Dental implant placement<br>* A dental implant with 4.8X 10 mm (Zimmer, USA) size was placed at the posterior of the mandible<br>|
| Placebo Comparator: Non Emitting group<br>In laser emitiiing group, subjects received Low-Level Laser and Light-Emitting Diodes after implant placement and in Non-emitting group,the same device was used while device was off. | Device: Low-Level Laser and Light-Emitting Diodes<br>* Combination of Low-Level Laser and Light-Emitting Diodes were used after dental implant placement for enhancement of stability<br>Device: Dental implant placement<br>* A dental implant with 4.8X 10 mm (Zimmer, USA) size was placed at the posterior of the mandible<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Resonance frequency analysis | The stability of the implants was evaluated with resonance frequency analysis by the Osstell device | Immidate after implant placement (time 0) | 
| Resonance frequency analysis | The stability of the implants was evaluated with resonance frequency analysis by the Osstell device | 10 days (time1) after implant placement | 
| Resonance frequency analysis | The stability of the implants was evaluated with resonance frequency analysis by the Osstell device | Three weeks after implant placement (time 2) | 
| Resonance frequency analysis | The stability of the implants was evaluated with resonance frequency analysis by the Osstell device | Six weeks after implant placement (time 3) | 
| Resonance frequency analysis | The stability of the implants was evaluated with resonance frequency analysis by the Osstell device | Nine weeks after implant placement(time 4) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Low-Level Light Therapy, Osseointegration