The Association Between Gene Polymorphisms and Infectious Complications After Liver Surgery

Study Overview
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Brief Summary
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The purpose of the study is to test whether the presence of polymorphisms in genes encoding substances of the innate immune response in patients undergoing partial hepatic resection because of benign or malignant hepatobiliary disease is related to a higher incidence of infectious complications, post-resectional liver failure or mortality.

Detailed Description
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Partial hepatic resection is a feasible and relatively safe procedure for selected patients with benign or malignant hepatobiliary disease. Liver failure after partial hepatic resection, so-called post-resectional liver failure (PLF), is a dreaded complication with high mortality rates. Patients suffering from PLF experience significantly more clinically significant infections (CSI) when compared with patients without PLF. The liver plays an important role in the body's innate immune defense. Recently, polymorphisms in genes encoding key molecules in the innate immune response (e.g. nuclear factor kappa-B) have shown to be associated with a greater risk of CSI. The presence of these polymorphisms combined with partial hepatic resection might render patients susceptible to the development of CSI, PLF and early mortality after liver resection.

Official Title
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The Association Between Gene Polymorphisms in the Innate Immune Response and the Risk of Infectious Complications and Liver Failure After Partial Hepatic Resection

Conditions
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Liver Disease

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age >18 years benign or malignant liver disease requiring partial hepatic resection Exclusion Criteria: inability to give informed consent liver disease judged irresectable after intra-operative evaluation use of immunosuppressive drugs resection < 1 segment unable to comply with follow-up

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| liver surgery<br>patients with benign or malignant hepatobiliary disease requiring partial hepatic resection | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| clinically significant infectious complications (i.e. wound infection, pneumonia, blood stream infection, gastro-intestinal infection, intra-abdominal infection, urinary tract infection and miscellaneous) |  | 90 days after liver surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| post-resectional liver failure |  | 90 days after liver surgery | 
| mortality |  | 90 days after liver surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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liver surgery, gene polymorphisms, innate immune response, infectious complications, post-resectional liver failure, mortality