Evaluation of 4 MRI Methods (PDFF 3, 6 and 11 Gradient Echoes and Spectroscopy) Compared to the Reference Method (Liver Biopsy) in Quantification of Hepatic Steatosis

Study Overview
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Brief Summary
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Evaluation of 4 MRI methods (PDFF 3, 6 and 11 gradient echoes and Spectroscopy) compared to the reference method (liver biopsy) in quantification of hepatic steatosis

Detailed Description
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Hepatic steatosis is an increasingly frequent pathology, which can lead to severe complications (Cirrhosis, Hepatocellular Carcinoma). The poor quantification of steatosis by ultrasound or scanning and the invasiveness of the reference method (liver biopsy) make MRI a measurement tool of choice. Recent techniques such as proton density measurement with several echoes or spectroscopy are increasingly used for the measurement of steatosis. At the time of the development of therapeutics to reduce fatty liver disease, the use of MRI seems an interesting alternative for longitudinal follow-up in these patients. Our study aims to ensure the reliability of these different MRI techniques for accurate quantification of liver steatosis and to compare them. Measurement and influence of hepatic fibrosis Measurement and influence of intrahepatic iron Influence of intercurrent liver disease Comparison of the fat measurement of the different hepatic segments Reproducibility by measurement of inter-observer concordance

Official Title
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Evaluation of 4 MRI Methods (PDFF 3, 6 and 11 Gradient Echoes and Spectroscopy) Compared to the Reference Method (Liver Biopsy) in Quantification of Hepatic Steatosis

Conditions
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Hepatic Steatosis, MRI, Liver Biopsy, Quantification

Intervention / Treatment
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* Procedure: Quantification of hepatic steatosis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients undergoing hepatic biopsy (trans-parietal or trans-jugular) in the context of liver disease signature of written consent Exclusion Criteria: Contra-indications to MRI Refusal of protocol underage patients and protected adults

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Hepatic steatosis<br>Evaluation of different techniques in quantification of hepatic steatosis by MRImaging (PDFF 3, 6 and 11 gradient echoes and Spectroscopy) compared to the histological method (reference) | Procedure: Quantification of hepatic steatosis<br>* Quantification of hepatic steatosis (histology, and in MRI)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation coefficient - for each quantitative MRI variable studied - with the histological score of hepatic steatosis. | Correlation coefficient - for each quantitative MRI variable studied - with the histological score of hepatic steatosis. | at day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of intrahepatic iron |  | at day 1 | 
| Measurement of intrahepatic fibrosis |  | at day 1 | 
| Measurement of fat in different hepatic segments | (MRI ) | at day 1 | 
| Concordance between observers | (for MRI measurements) | at day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hepatic steatosis, MRImaging