Sarcopenia in Axial and Peripheral Spondyloarthropathies

Study Overview
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Brief Summary
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Spondylarthropathies (SpA) are among the most common chronic inflammatory rheumatisms in adults, responsible for a muscular loss or sarcopenia which can be very disabling, not much documented in the literature, and not yet studied in France. In addition, sarcopenia is associated with decreased physical activity and increased risk of falls and fractures. A better characterization of the determinants of this muscular loss will allow to better detect and take care of it. The aim is to conduct the first French study on the prevalence and severity of sarcopenia in patients with spondyloarthropathies and to study the variables that may be associated with it. Finally, we propose to evaluate obesity related to sarcopenia in these patients and compare them to cases matched for age and sex (from OFELY / STRAMBO cohorts, Lyon, FRANCE). This is a prospective interventional and monocentric study with minimal risks and constraints: patients will be included for one day for an evaluation of their sarcopenia by measuring their muscle strength, physical performance and body composition and recording of their socio-demographic and disease characteristics.

Official Title
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Sarcopenia in Axial and Peripheral Spondyloarthropathies

Conditions
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Spondylarthropathy, Sarcopenia

Intervention / Treatment
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* Other: Dynamometry exam
* Other: Walking test
* Radiation: DXA measurement
* Other: SARQOL questionnaire
* Behavioral: Life habits Questionnaire


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men and women, 18 to 80 years old Hospitalized or attending the rheumatology department for spondyloarthopathy. Exclusion Criteria: no signed consent Immobilization for a period of more than 15 days during the last 3 months pregnant or breastfeeding woman Not affiliated to the national healthcare insurance difficulty in understanding French psychiatric disorder

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patients with SpA<br>Patients included in this single group study will have 3 interventions to assess the severity of muscle loss : dynamometry exam walking test Dual-energy X-ray Absorptiometry (DXA) measurement Quality of life will be assessed with Sarcopenia & Quality of Life (SARQOL) questionnaire. Patients will also fill a Life habits Questionnaire. | Other: Dynamometry exam<br>* Prehension strength of the main hand will be assessed thanks to dynamometry, in order to evaluate patient's muscular strength<br>Other: Walking test<br>* A 4 metres walking test will be performed to assess patient's walking speed<br>Radiation: DXA measurement<br>* DXA measurement will be performed to assess patient's body composition<br>Other: SARQOL questionnaire<br>* Patient's quality of life will be assessed thanks to the SARQOL questionnaire<br>Behavioral: Life habits Questionnaire<br>* Life habits Questionnaire<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscular strength | Muscular strength is the first outcome to evaluate sarcopenia | At day 1 | 
| Walking speed | Walking speed is a physical performance outcome, that is the second outcome to evaluate sarcopenia | At day 1 | 
| Muscular mass | Muscular mass is the third outcome to evaluate sarcopenia and will be assessed using DXA | Up to 4 month after inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Alcohol consumption |  | At day 1 | 
| Tobacco consumption |  | At day 1 | 
| Time of sport practice per month | Number of hours of sport practice per month is the first outcome to evaluate patient's global physical activity. | At day 1 | 
| Physical activity rate in work | Physical activity rate in work can be light, medium, high or not applicable if the patient does not work ; it is the second outcome to evaluate patient's physical global activity. | At day 1 | 
| Average walking time in a week | Average walking time in a week is the third outcome to evaluate patient's physical global activity. | At day 1 | 
| Score at the SARQOL questionnaire | Quality of life will be assessed thanks to the SARQOL questionnaire (score between 0 and 100) | At day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Spondylarthropathy, Sarcopenia, lean mass, fat mass