HIT in People With Type 1 Diabetes

Study Overview
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Brief Summary
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Few people with type 1 diabetes achieve exercise guidelines and many programmes designed to increase physical activity have failed. High-intensity interval training (HIT) has been shown to be a time-efficient alternative to traditional moderate-intensity continuous training (MICT) in various groups without type 1 diabetes. A single bout of HIT does not increase the risk of hypoglycaemia in people with type 1 diabetes. This study aimed to assess whether HIT a safe, effective and time-efficient training strategy to improve cardio-metabolic health and reduce the risk of hypoglycaemia in people with type 1 diabetes.

Detailed Description
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This study aimed to investigate whether 1) six weeks of high-intensity interval training (HIT) induces similar improvements in cardio-metabolic health markers as moderate-intensity continuous training (MICT) in people with type 1 diabetes, and 2) whether HIT abolishes acute reductions in plasma glucose observed following MICT sessions. Fourteen sedentary individuals with type 1 diabetes (n=7 per group) completed six weeks of HIT or MICT 3 times per week. Pre- and post-training measurements were made of 24h interstitial glucose profiles (using continuous glucose monitors (CGMS)) and cardio-metabolic health markers (V ̇O2peak, blood lipid profile and aortic pulse wave velocity; aPWV). Capillary blood glucose concentrations were assessed before and after exercise sessions throughout the training programme to investigate changes in blood glucose during exercise in the fed state.

Official Title
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High-Intensity Interval Training Improves Aerobic Capacity and Abolishes the Decline in Blood Glucose Observed During Moderate-Intensity Continuous Training Sessions in People With Type 1 Diabetes

Conditions
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Type1diabetes

Intervention / Treatment
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* Other: HIT
* Other: MICT


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: duration of type 1 diabetes >6 months basal bolus regimen no significant history of hyper- or hypoglycaemia (determined from medical history) Exclusion Criteria: duration of type 1 diabetes <6 months, insulin pump therapy significant history of hyper- or hypoglycaemia (determined from medical history) obesity (BMI >30 kg∙m-2) pregnancy or planning pregnancy uncontrolled hypertension (>180/100 mmHg) angina, autonomic neuropathy taking any medication that affects heart rate major surgery planned within 6 weeks of the study severe nonproliferative unstable proliferative retinopathy

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: HIT training<br>6 weeks of high-intensity interval training (HIT) | Other: HIT<br>* Participants completed 6 weeks of HIT<br>|
| Experimental: Moderate intensity training<br>6 weeks of moderate-intensity continuous training (MICT) | Other: MICT<br>* Participants completed 6 weeks of MICT<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximal aerobic capacity | Maximal aerobic capacity test pre and post 6-week training intervention | change in baseline maximal aerobic capacity at 6 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vascular stiffness | Aortic pulse wave velocity to measure vascular stiffness | change in baseline vascular stiffness at 6 weeks |