Epidemiology of Osteoarthritis (OA) Pain

Study Overview
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Brief Summary
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Chronic pain, by definition, persists over long periods of time, but both sufferers of pain and their caregivers are aware that pain levels can fluctuate greatly over time. Being able to define pain variability and its underlying causes would be an important advance in our understanding of chronic pain, and would in turn lead to better approaches to the treatment of chronic pain. In this study, the investigators propose to evaluate in 60 people with chronic pain of the knee due to osteoarthritis over 3 months, collecting data regarding magnitude of pain, physical activity level, and medication status twice daily during this period of time. The investigators then will assess the variability in pain levels over time, the frequency of flares of osteoarthritis (OA) pain and their relationship to physical activity, medications, and clinical descriptors of the population, e.g., age, gender, body mass index (BMI). Additionally, evaluations will be made regarding temporal patterns of OA knee pain as well as assessment of subgroups of patients with the overall group being studied.

Official Title
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Epidemiology of OA Pain

Conditions
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Osteoarthritis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men and women, age 40 years and above Knee pain most days of the week for the past month Diagnosis of knee OA Meet ACR criteria for knee OA No significant limitations in physical activity Own and able to use a cellular phone capable of text messaging Able to return for all clinic visits Able to read and understand the informed consent document Exclusion Criteria: Use of a walker to ambulate or inability to ambulate (use of cane is allowed) Other forms of arthritis Other major causes of pain that could be expected to interfere with assessment of pain during this trial, e.g., recurrent migraine, back pain, fibromyalgia Scheduled for and likely to need joint replacement surgery in the next 3 months Any medical condition that in the judgment of the investigator would make the participant not suitable for the study Living in a long-term care facility

Ages Eligible for Study
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Minimum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No treatment<br>OA | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pain magnitude | magnitude of pain will be evaluated 3x/day | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| self-reported activity level | data will be collected 3x/day; Likert 1-5 scale | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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OA, osteoarthritis, pain, variability, activity, treatment