The Value of PSP in Predicting Outcome in ICU Surgical Peritonitis Patients

Study Overview
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Brief Summary
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The purpose of this study is to determine the diagnostic accuracy of Pancreatic Stone Protein (PSP) in predicting patient outcomes with suspected peritonitis in the Intensive Care Unit after abdominal surgery and compare PPS with other blood parameters, including C-Reactive Protein (CRP), White Cell Count (WCC), Interleucin-6 (IL-6) and Procalcitonin (PCT).

Detailed Description
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Peritonitis is a severe complication after abdominal surgery. Patients admitted at the Intensive Care Unit (ICU) following surgery bear the risk of localized infection, sepsis or septic shock. Prevention or early detection of such events is important to intervene with an appropriate therapeutic action and avoid risking a potentially life-threatening situation. White blood cell counts (WCC) and C-Reactive Protein (CRP), Interleucin-6 (IL-6) and Procalcitonin (PCT) have all been promising parameters, however, they are useful only in selective cases and have a limited diagnostic accuracy.

Official Title
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Diagnostic Accuracy of Pancreatic Stone Protein in Predicting Severe Outcome in Patients With Peritonitis at the Intensive Care Unit

Conditions
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Sepsis, Peritonitis, Multiple Organ Failure, Death

Intervention / Treatment
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* Procedure: All abdominal surgical procedures
* Procedure: Intubation
* Radiation: Imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Abdominal surgery. Admission to the Intensive Care Unit (ICU). Blood sampling within 3 hours from admission to the ICU Patient over 18 years of age Exclusion Criteria: Patients already treated for peritonitis. Patients referred from other hospitals with suspicion of peritonitis Patient age less than 18 years of age.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control<br>Admission to the Intensive Care Unit (ICU) after abdominal surgery without suspicion / evidence of peritonitis. | Procedure: All abdominal surgical procedures<br>* Laparotomy, Laparoscopy<br>* Other names: surgical procedures;Procedure: Intubation<br>* Ventilatory support<br>* Other names: Endotracheal Intubation, tracheostomy;Radiation: Imaging<br>* Abdominal ultrasound Computer Tomography Magnetic Resonance Imaging<br>* Other names: Any type of diagnostic or interventional imaging technique;|
| Peritonitis<br>Admission to the Intensive Care Unit (ICU) after abdominal surgery with suspicion / evidence of peritonitis | Procedure: All abdominal surgical procedures<br>* Laparotomy, Laparoscopy<br>* Other names: surgical procedures;Procedure: Intubation<br>* Ventilatory support<br>* Other names: Endotracheal Intubation, tracheostomy;Radiation: Imaging<br>* Abdominal ultrasound Computer Tomography Magnetic Resonance Imaging<br>* Other names: Any type of diagnostic or interventional imaging technique;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Localization of Peritonitis | Localised vs. diffused. A clinical finding intra-operatively and/or radiologically (i.e. CT or MRI) | up to 2 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Peritonitis, Sepsis, General Surgery, Intensive Care Units, Sensitivity and Specificity