Lavender Oil on Preoperative Anxiety and Sedation Requirement in General Anaesthesia

Study Overview
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Brief Summary
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Assessment of how Lavender oil reduces preoperative anxiety and subsequently influences requirement of induction agents for general anesthesia.

Detailed Description
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This study aims to use aromatherapy (Lavender oil) to reduce Preoperative Anxiety among Female patients coming for elective surgeries under General Anesthesia. As a consequence of that, the effect is also evaluated on how that influences the amount of intravenous sedation is required during induction for General Anesthesia.

Official Title
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Lavender Aromatherapy; Its Effect on Preoperative Anxiety and Propofol Requirement for Anaesthesia.

Conditions
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Preoperative Anxiety

Intervention / Treatment
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* Other: Lavender Oil on Nasal Strip (Lx)
* Other: Strip without Lavender Oil (Px)
* Drug: Propofol 1 % Injectable Suspension


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18-65 Female Exclusion Criteria: Patients on B-blockers and or antidepressants. BMI > 35kg/m2 History of atopy History of alcoholism, substance abuse, smoking Patients with cancer

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Strip with Lavender Oil (Lx)<br>Application of Nasal Strip with essential oil (Lavender), 20minutes before induction. VAS- Anxiety scores pre and post inhalation. | Other: Lavender Oil on Nasal Strip (Lx)<br>* Usage of Aromatherapy for Preoperative Anxiety<br>Drug: Propofol 1 % Injectable Suspension<br>* Propofol 1% (10mg/mL)<br>|
| Placebo Comparator: Strip without Lavender Oil (Px)<br>Application of Nasal strip without essential oil, acting as placebo. VAS- Anxiety scores pre and post placebo. | Other: Strip without Lavender Oil (Px)<br>* Strip without Lavender Oil (Px)<br>Drug: Propofol 1 % Injectable Suspension<br>* Propofol 1% (10mg/mL)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 1. Visual Analog Scoring for Anxiety | Self reported anxiety score before and after inhalation of aromatherapy. 3 questions about preoperative anxiety are asked and scoring is done based on a 0-10cm scale (0= no anxiety, 10= agonizing anxiety). Cumulative scores for all 3 questions above 5 indicates preoperative anxiety. | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 1. Amount of sedation used to achieve Loss of Consciousness | Induction for general anesthesia using Target control Infusion of Propofol 1% (10mg/mL) using the Schnider protocol, administered via a TIVA Agilia infusion pump to achieve a target plasma concentration of 4mcg/ml until loss of consciousness. | Less than 30minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Lavender Oil,, Propofol