linjc16/ctgov huggingface dataset:
Comparison of Three Methods of Anesthesia to Achieve a Nerve Block Anesthesia.

Study Overview
=================
Brief Summary
-----------------
Evaluation of three methods for the realization of a neuronal blockade.

Detailed Description
-----------------
Evaluation of three methods during the realization of a neuronal blockade. The three stimulations were: 1) echography, 2) echography and neurostimulation, and 3) echography, neurostimulation, and active mobilization by the patient.

Official Title
-----------------
Comparison of Three Methods of Anesthesia to Achieve a Nerve Block Anesthesia.

Conditions
-----------------
Anesthesia

Intervention / Treatment
-----------------
* Other: Echography
* Other: Echography and neurostimulation
* Other: Echography, neurostimulation and active mobilization


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 216 consecutive adult patients scheduled for an elective hand surgery Exclusion Criteria: Patient refusal

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Echography<br>For the neuronal blockade of the patient, anesthesiologists used an echography. | Other: Echography<br>* Neuronal blockade anesthesia for elective surgery of the hand was performed with an only echography.<br>Other: Echography and neurostimulation<br>* Neuronal blockade anesthesia for elective surgery of the hand was performed with both echography and neurostimulation.<br>Other: Echography, neurostimulation and active mobilization<br>* Neuronal blockade anesthesia for elective surgery of the hand was performed with echography, neurostimulation, and active mobilization.<br>|
| Other: Neurostimulation<br>For the neuronal blockade of the patient, anesthesiologists used neurostimulation. | Other: Echography and neurostimulation<br>* Neuronal blockade anesthesia for elective surgery of the hand was performed with both echography and neurostimulation.<br>Other: Echography, neurostimulation and active mobilization<br>* Neuronal blockade anesthesia for elective surgery of the hand was performed with echography, neurostimulation, and active mobilization.<br>|
| Other: Active mobilization<br>For the neuronal blockade of the patient, anesthesiologists used active mobilization. | Other: Echography, neurostimulation and active mobilization<br>* Neuronal blockade anesthesia for elective surgery of the hand was performed with echography, neurostimulation, and active mobilization.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time | Time to obtain a complete neuronal blockade of the hand | Measurements was performed during 20 minutes after the completion of the neuronal blockade. |
The Correlation Between MAGE-A3, PRAME Polymorphism and Expression Levels of MAGE-A3 and PRAME in NSCLC Patients

Study Overview
=================
Brief Summary
-----------------
Considering the low expression rate of Melanoma-associated antigen 3 (MAGE-A3) in Asian especially Southeast Asian, it would be great interests to investigate the potential polymorphism of MAGE-A3 in Non-Small-Cell Lung Cancer (NSCLC) patients in Taiwan. Meanwhile, it is also interesting to study the expression of Preferentially Expressed Antigen In Melanoma(PRAME) and Epidermal growth factor receptor (EGFR) mutation status as well as to find out significant factors which may affect their expression such as smoking status, histological types, tumour size and stages in Taiwan.

Detailed Description
-----------------
Considering the low expression rate of MAGE-A3 in Asian especially Southeast Asian, it would be great interests to investigate the potential polymorphism of MAGE-A3 in NSCLC patients in Taiwan. Meanwhile, it is also interesting to study the expression of PRAME and EGFR mutation status as well as to find out significant factors which may affect their expression such as smoking status, histological types, tumour size and stages in Taiwan

Official Title
-----------------
An Observational Study to Determine the Correlation Between MAGE-A3, PRAME Polymorphism and Expression Levels of MAGE-A3 and PRAME in NSCLC Patients in Taiwan

Conditions
-----------------
Carcinoma, Non-Small-Cell Lung

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Tissues samples up to 200 cases of NSCLS patients with informed consent, consisting of about 100 cases of adenocarcinoma (AC) and 100 cases of squamous cell carcinoma (SCC), with stage of IB, IIA, IIB and IIIA Exclusion Criteria: - No

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with at least one MAGE-A3 gene single nucleotide polymorphism (SNP) |  | up to 44 months |
Analysis of Adherence & Associated Factors in Teenagers Undergoing Treatment of Acne Vulgaris With Differin® Gel 0.1%

Study Overview
=================
Brief Summary
-----------------
The primary objective of this study is to investigate potential differences in treatment adherence by teenagers among four interventions during treatment for acne.

Detailed Description
-----------------
Same as above.

Official Title
-----------------
An Analysis of Adherence and Associated Factors in Subjects Undergoing Differin® Gel, 0.1% Treatment of Moderate to Severe Acne Vulgaris.

Conditions
-----------------
Acne

Intervention / Treatment
-----------------
* Other: More frequent than normal office visits
* Other: Electronic reminders (voice, e-mail, text messages)
* Other: Parenteral involvement / intervention reminders
* Other: No intervention or reminders


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adolescent subjects with a diagnosis of moderate to severe Acne vulgaris Exclusion Criteria: Subjects with acne conglobata, acne fulminans, secondary acne (chloracne, drug-induced acne, etc.), or severe acne requiring more than topical treatment (e.g. oral isotretinoin)

Ages Eligible for Study
-----------------
Minimum Age: 13 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1<br>More frequent than normal office visits | Other: More frequent than normal office visits<br>* Mode of patient reminder<br>|
| Active Comparator: 2<br>Electronic reminders (voice, e-mail, text messages) | Other: Electronic reminders (voice, e-mail, text messages)<br>* Mode of patient reminder<br>|
| Active Comparator: 3<br>Parental involvement / intervention reminders | Other: Parenteral involvement / intervention reminders<br>* Mode of patient reminder<br>|
| Active Comparator: 4<br>No intervention or reminders | Other: No intervention or reminders<br>* Mode of patient reminder<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Efficacy - Percent adherence calculated from MEMS Caps readings |  | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Efficacy - lesion counts; percent adherence as calculated by product weights and by Subject's Diary; Global Severity Assessment; Global Assessment of Improvement; Subject questionnaire |  | 12 weeks | 
| Safety - tolerability and adverse event reporting |  | 12 weeks |
Physical Activity for Improving Quality of Life and Reducing Frailty in Advanced Age

Study Overview
=================
Brief Summary
-----------------
Individuals of advanced age undergo both physical and cognitive deterioration. The aim of this study is to explore the connection between level of physical activity and health parameters, quality of life, and frailty.

Official Title
-----------------
Physical Activity for Improving Quality of Life and Reducing Frailty in Advanced Age: Individually Tailored Program vs the General Guidelines Recommended by Offical Health Organizations.

Conditions
-----------------
Aging

Intervention / Treatment
-----------------
* Behavioral: Physical Activity


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age above 65 Able to undergo graded stress exam Exclusion Criteria: All others

Ages Eligible for Study
-----------------
Minimum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Individualized Program<br>Based on personal fitness an individualized physical activity program will be built and followed by each individual in the arm | Behavioral: Physical Activity<br>* Physical activity either by individualized program or general guidelines<br>|
| Active Comparator: General Physical Activity Guidelines<br>The entire group of individuals in this arm will follow a physical activity program according to the General Physical Activity Guidelines | Behavioral: Physical Activity<br>* Physical activity either by individualized program or general guidelines<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Aerobic Fitness | Aerobic fitness will be measured with a graded stress exam | One year |
YKL-40 and IL-6 Levels in Periodontal Disease

Study Overview
=================
Brief Summary
-----------------
The primer aim of the study was to investigate saliva and gingival crevicular fluid (GCF) YKL-40 and also interleukin-6 (IL-6) levels in chronic periodontitis pathogenesis.

Detailed Description
-----------------
This study consisted of two groups: 26 periodontally healthy individuals and 26 generalized chronic periodontitis patients. Chronic periodontitis patients were received nonsurgical periodontal treatment. Clinical measurements were recorded, saliva and GCF samples were obtained before and at first and third months after periodontal therapy. Levels of YKL-40 and IL-6 in saliva and GCF were analyzed by enzyme-linked immunosorbent assay.

Official Title
-----------------
Effect of Non-Surgical Periodontal Therapy on Salivary and Gingival Crevicular Fluid YKL-40 and IL-6 Levels in Chronic Periodontitis

Conditions
-----------------
Periodontal Diseases

Intervention / Treatment
-----------------
* Procedure: Nonsurgical periodontal therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Group 1 Inclusion Criteria: No bone and attachment loss, GI=0, PPD≤3mm, CAL≤3mm Systematically healthy patients Group 2 Inclusion Criteria: GI>1, PPD≥5mm, CAL≥5mm with alveolar bone loss radiographically. Systematically healthy patients Exclusion Criteria: Aggressive Periodontitis, Patients with any other systemic diseases, Pregnant women and those in the lactation period, Patients with smoking habit and taking medication Patients received periodontal therapy in last 6 month

Ages Eligible for Study
-----------------
Minimum Age: 26 Years
Maximum Age: 49 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1<br>Periodontally healthy individuals | |
| Group 2<br>Chronic periodontitis patients | Procedure: Nonsurgical periodontal therapy<br>* Nonsurgical periodontal therapy includes oral hygiene education and scaling and root planning approaches to eliminate microbial dental plaque that is the primary etiology of periodontal diseases.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| YKL-40 levels | changes in YKL-40 levels after periodontal therapy | at first and third month after therapy | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| IL-6 levels | changes in IL-6 levels after periodontal therapy | at first and third month after therapy |
ُEfficacy of Insulin Versus Hyalase Hydro-dissection of Median Nerve in Rheumatoid Arthritis Patients

Study Overview
=================
Brief Summary
-----------------
Carpal tunnel syndrome (CTS) is a common peripheral entrapment neuropathy in Rheumatoid arthritis patients proved by nerve conduction studies and ultrasound parameters, this study aims to evaluate the effect of hydro-dissection using insulin versus hyalase versus saline, ultrasounic guided as an effective treatment

Detailed Description
-----------------
Carpal tunnel syndrome (CTS) is a common peripheral entrapment neuropathy in Rheumatoid arthritis patients proved by nerve conduction studies and ultrasound parameters, this study aims to evaluate the effect of hydro-dissection of median nerve inside CT twice injections with interval 2 weeks using insulin and 10 cc saline versus hyalase and 10 cc saline versus 10 cc saline, ultrasounic guided as an effective treatment of CT

Official Title
-----------------
Treatment of Carpal Tunnel in Rheumatoid Arthritis

Conditions
-----------------
Treatment Resistant Carpal Tunnel in RA Patients

Intervention / Treatment
-----------------
* Drug: Hylase
* Drug: Insulin
* Other: saline


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Rheumatoid arthritis in remission Exclusion Criteria: active Rheumatoid arthritis

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Hyalase<br>injection and hydro-dissection of median nerve using hyaluronidase followed by 10 cc normal saline ultrasonic guided | Drug: Hylase<br>* hydro-dissection injection of median nerve inside carpal tunnel using hyalase and 10 cc saline<br>* Other names: Hyaluronidase;|
| Placebo Comparator: Placebo<br>injection and hydro-dissection of median nerve hydro-dissection using 10 cc saline injection ultrasonic guided | Other: saline<br>* hydro-dissection injection of median nerve inside carpal tunnel using 10 cc saline<br>* Other names: normal saline;|
| Active Comparator: Insilin<br>injection and hydro-dissection of median nerve hydro-dissection using 10 IU insuline followed by 10 cc normal saline ultrasonic guided | Drug: Insulin<br>* hydro-dissection injection of median nerve inside carpal tunnel using 10 IU insulin and 10 cc saline<br>* Other names: crystalline insulin;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pain intensity | Visual analog scale 0-100 | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| nerve conduction | sensory velocity | 6 months | 
| ultrasound | cross sectional area | 6 months |
Effect of Thoracic Paravertebral Block on Heart Rate Variability (HRV)

Study Overview
=================
Brief Summary
-----------------
The Left thoracic paravertebral block have a different effect on heart's autonomic nervous system, as measured with Heart Rate Variability, compared to Right interscalene block

Official Title
-----------------
Effect of Thoracic Paravertebral Block on the Autonomous System as Measured by Heart Rate Variability (HRV)

Conditions
-----------------
Breast Surgery, Thoracic Paravertebral Block, HRV, Autonomic Nervous System

Intervention / Treatment
-----------------
* Other: Left thoracic paravertebral block
* Other: Right thoracic paravertebral block


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Elective breast surgery Age 20 - 65 years ASA I - II Exclusion Criteria: Coagulopathy disorders Infection at the puncture site for the thoracic paravertebral block Severe kyphoscoliosis Allergy to local anesthetics BMI > 35 Psychiatric disorders Patient's refusal Problems with patient communication Arrythmia Ischaemic heart disease Diabetes mellitus Thyroid function disorders Patients with conduction disorders on the ECG Electrolyte disorders (K+, Na+, Ca++) Patients on medication that affect the ECG

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Left thoaracic paravertebral block<br>Surgery in the left breast under left thoracic paravertebral block and HRV | Other: Left thoracic paravertebral block<br> <br> |
| Right thoracic paravertebral block and HRV<br>Surgery in the right breast under right thoracic paravertebral block and HRV | Other: Right thoracic paravertebral block<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect of thoracic paravertebral block on Heart Rate Variability (HRV) | The Left thoracic paravertebral block has different effect on heart's autonomic nervous system, as measured with HRV, than the Right. | 30 min after the application of the thoracic paravertebral block | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Breast Surgery, Thoracic Paravertebral Block, HRV, Autonomic Nervous System
Aquagenic Pruritus in Myeloproliferative Neoplasms

Study Overview
=================
Brief Summary
-----------------
Description of the characteristics of aquagenic pruritus expressed by patients suffering from myeloproliferative neoplasms. Prospective work based on the distribution of a dedicated questionnaire.

Detailed Description
-----------------
Patients with myeloproliferative neoplasms identified and followed in French Hospitals. Patients could be followed for polycythemia vera or essential thrombocythemia or primary myelofibrosis. Distribution of the questionnaire to each patient with myeloproliferative neoplasm (treated or not) suffering from aquagenic pruritus. Analyse of each characteristic of the aquagenic pruritus by a statistician and publication at the end.

Official Title
-----------------
Aquagenic Pruritus in Myeloproliferative Neoplasms

Conditions
-----------------
Deciphering Aquagenic Pruritus in Myeloproliferaitive Neoplasms

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with one of three non-chromosomal Philadelphia-positive myeloproliferative neoplasms: polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Suffering (or having suffered) from aquagenic pruritus. No age limit, but major Patient having formulated his non-opposition Exclusion Criteria: Patients with MPN with non-aquagenic pruritus, Patients with another hematologic disease and aquagenic pruritus Patients unable to complete the questionnaire. Patients with physical or mental disabilities to formulate non-opposition Refusal of participation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Description of pruritus in patients with myeloproliferative neoplasms | Intensity of pruritus (visual analogic scale) | at the time of questionnaire completion (Day 0) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Description of therapies used to treat pruritus | Name of drugs used | at the time of questionnaire completion (Day 0) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pruritus, Myeloproliferative Neoplasms