Prospective Evaluation of Breast Cancer at Brazilian Institutions - Project AMAZONA III

Study Overview
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Brief Summary
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The principal goal of this study is to describe the epidemiology of breast cancer in the Brazilian population

Detailed Description
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The principal goal of this study is to describe the epidemiology of breast cancer in the Brazilian population. Other specific goals are: To evaluate the demographic and socio-demographic profile, comorbidities and reproductive risks, anthropometric profile and family history. Characterize the breast tumors immunophenotype through anatomopathological data, such as: tumor grade, estrogen receptor, progesterone receptor, HER2, Ki67. Describe the screening tests, main symptoms and cancer stage in the moment of the diagnosis. Describe the initial cancer treatment and locally advanced such as surgery, radiotherapy, chemotherapy and endocrine therapy. Describe palliative treatment for recurrent or metastatic breast cancer: chemotherapy, radiotherapy, biphosphonate, and others. Evaluate the clinical outcomes such as: local or diffuse relapse, period of time until progression to metastatic cancer, global lifespan and specific breast cancer lifespan. Evaluate clinical complications of the metastatic disease, such as: brain metastasis, spinal cord compression, skeletal related events. Analyze the demographical and socio-economical characteristics, clinical-pathological characteristics of the tumor, treatment, clinical outcomes, type of institution (private/public), and other factors that may impact clinical outcome.

Official Title
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Prospective Evaluation of Breast Cancer at Brazilian Institutions - Project AMAZONA III

Conditions
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Breast Cancer

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Woman ≥ 18 years old Invasive breast cancer stage I to IV proven by histology or cytology Patients with new pathological diagnosis of invasive primary BC after the site activation date Pathological diagnosis of invasive breast cancer during recruitment (6 months before center activation or until 3000 patients included) New primary cancer on the same breast or contralateral breast. Patient's medical chart is available and adequate for data collection Patient properly signed the informed consent form

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Description of the epidemiology of breast cancer in the Brazilian population |  | Annually, during 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Description of the socioeconomical characteristics of the Brazilian population with breast cancer |  | Annually, during 5 years | 
| Characterization of the immunophenotypic markers of the tumor | estrogen receptor, progesterone receptor, HER2, Ki67 | Annually, during 5 years | 
| Classification of breast cancer staging |  | Annually, during 5 years | 
| Description of screening tests of breast cancer patients in Brazil |  | Annually, during 5 years | 
| Main symptoms presented by patients with breast cancer in Brazil |  | Annually, during 5 years | 
| Initial treatment for breast cancer of Brazilian patients |  | Annually, during 5 years | 
| Type of palliative treatment for metastasis or recurrent breast cancer in Brazilian patients |  | Annually, during 5 years | 
| Clinical outcome of Brazilian breast cancer patients |  | Annually, during 5 years | 
| Types of clinical complications displayed by breast cancer Brazilian patients |  | Annually, during 5 years | 
| Characterization of exterior factors that may impact clinical outcome of breast cancer Brazilian patients |  | Annually, during 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Breast cancer