Individualized Transcranial Direct Current Stimulation for Gait Function in Healthy Subjects

Study Overview
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Brief Summary
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The purpose of this study is to compare the effects of individualized brain stimulation based on simulation and conventional brain stimulation in healthy adults.

Official Title
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Individualized Transcranial Direct Current Stimulation for Gait Function in Healthy Subjects

Conditions
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Healthy Adults, Healthy Aging

Intervention / Treatment
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* Device: Individualized transcranial direct current stimulation
* Device: Conventional transcranial direct current stimulation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • Healthy adult men and women without history of central nervous system disease and abnormalities Exclusion Criteria: Under 18 years old, 75 years old or older A person who has inserted a metal object in a skull A person with complete occlusion of the carotid artery A person with epilepsy Pregnant and lactating women Who is not eligible for the test

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Individualized stimulation group<br>Based on transcranial direct current stimulation (tDCS) simulation, individualized stimulation on leg motor areas during 30 minutes. | Device: Individualized transcranial direct current stimulation<br>* Based on tDCS stimulation, individualized stimulation during 30 minutes with sitting position.<br>|
| Active Comparator: Conventional stimulation group<br>Conventional stimulation on leg motor areas during 30 minutes. | Device: Conventional transcranial direct current stimulation<br>* Conventional tDCS stimulation during 30 minutes with sitting position.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in cortical activation | changes in cortical activation is measured by functional Near-Infrared-Spectroscopy (fNIRS) (NIRScout, NIRx, Germany) during treadmill gait. | Change from baseline (before stimulation) after stimulation during 30 min | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 10 meter walk test (10MWT) | Measure of self selected speeds by measuring the time it takes an individual to walk 10 meters. To perform the test, patient walks 10 meters (33 ft) and the time is measured when the leading foot crosses the start line and the finish line. The instructions are: Please walk this distance at your normal pace when I say go. | Before stimulation (baseline); After strimulation during 30 min | 
| Timed Up and Go test (TUG) | The Timed Up and Go test (TUG) is a simple test used to assess a person's mobility and requires both static and dynamic balance. It uses the time that a person takes to rise from a chair, walk three meters, turn around, walk back to the chair, and sit down. | Before stimulation (baseline); After strimulation during 30 min | 
| Gait analysis using surface electromyograph | Gait analysis is a process of measuring and evaluating the walking patterns of patients by using surface electromyograph. | Before stimulation (baseline); After strimulation during 30 min | 
| Gait analysis using motion analysis system | Gait analysis is a process of measuring and evaluating the walking patterns of patients by using motion analysis system. | Before stimulation (baseline); After strimulation during 30 min | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Brain Stimulation, Transcranial direct current stimulation, Motor function