Phenoxodiol in Treating Patients With Refractory Solid Tumors

Study Overview
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Brief Summary
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RATIONALE: Phenoxodiol may stop the growth of tumor cells by blocking the enzymes necessary for cancer cell growth. PURPOSE: Phase I trial to study the effectiveness of phenoxodiol in treating patients who have refractory solid tumors.

Detailed Description
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OBJECTIVES: Determine the maximum tolerated dose of phenoxodiol in patients with refractory solid tumors. Determine the steady-state pharmacokinetics of this drug in these patients. Determine the tumor response in patients treated with this drug. OUTLINE: This is a multicenter, dose-escalation study. Patients receive phenoxodiol IV continuously over days 1-7. Treatment repeats every 14 days in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients receive escalating doses of phenoxodiol until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. Patients are followed at 4 weeks. PROJECTED ACCRUAL: Approximately 18-36 patients will be accrued for this study.

Official Title
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Phase IB Study of Phenoxodiol Given by Constant Intravenous Infusion in Patients With Solid Neoplasms (With the Exception of Breast Cancer) Whose Tumors Are Refractory to Standard Therapy

Conditions
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Unspecified Adult Solid Tumor, Protocol Specific

Intervention / Treatment
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* Drug: idronoxil


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Histologically or cytologically confirmed solid tumor Refractory to standard therapy OR No standard therapy exists No breast cancer No active CNS metastases Known CNS metastases must be previously treated with radiotherapy or surgery and stable for at least 4 weeks prior to study PATIENT CHARACTERISTICS: Age: 18 and over Performance status: Karnofsky 60-100% Life expectancy: At least 3 months Hematopoietic: Platelet count greater than 100,000/mm^3 WBC greater than 3,000/mm^3 Neutrophil count greater than 1,500/mm^3 Hemoglobin greater than 10 g/dL (9 g/dL for women) Hepatic: Bilirubin less than 1.2 mg/dL Transaminases no greater than 3 times upper limit of normal Renal: Creatinine no greater than 1.4 mg/dL Other: No active infection No contraindication to the insertion of a vascular access device Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: No concurrent systemic anticancer immunotherapy Chemotherapy: No concurrent systemic anticancer chemotherapy Endocrine therapy: No concurrent systemic anticancer hormonal therapy except luteinizing hormone-releasing hormone agonists or antagonists Radiotherapy: See Disease Characteristics Concurrent localized radiotherapy for control of local disease complications allowed Surgery: See Disease Characteristics Other: Recovered from prior antineoplastic therapy At least 4 weeks since prior investigational agents No other concurrent investigational drugs

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: idronoxil|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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unspecified adult solid tumor, protocol specific