Associations of Vitamin D Deficiency and Vitamin D Receptor Polymorphisms With the Risk of Primary Open-angle Glaucoma

Study Overview
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Brief Summary
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This study investigated whether vitamin D receptor gene polymorphism is altered in primary open-angle glaucoma subjects carrying the risk allele and vitamin D deficiency is an important factor in the development of glaucoma. Primary open-angle glaucoma patients and age-matched people in the Han population were enrolled. Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by enzyme-linked immunoabsorbent assay. Vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis.

Official Title
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Associations of Vitamin D Deficiency and Vitamin D Receptor Polymorphisms With the Risk of Primary Open-angle Glaucoma

Conditions
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Vitamin D Deficiency, Primary Open- Angle Glaucoma

Intervention / Treatment
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* Other: Vitamin D receptor polymorphic analysis
* Other: Serum levels of 1a, 25-Dihydroxyvitamin D3


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: intraocular pressure greater than 22 mmHg with two or more medications wide anterior chamber angle glaucomatous optic neuropathy (Glaucomatous optic nerve damage was defined as cup-to-disc ratio higher than 0.7 or focal loss of the nerve fiber layer (notch) associated with a consistent glaucomatous visual field defect) visual field loss consistent with optic nerve damage and visual fields were performed by using standard automated perimetry Exclusion Criteria: the presence of any secondary glaucoma including exfoliation syndrome or a history of ocular trauma high myopia macular degeneration other ocular diseases a known history of systemic diseases and administration of vitamin D3 or other analog

Ages Eligible for Study
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Minimum Age: 55 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| primary open-angle glaucoma patients<br>Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by enzyme-linked immunoabsorbent assay and vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis in primary open-angle glaucoma patients. | Other: Vitamin D receptor polymorphic analysis<br>* Vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis.<br>Other: Serum levels of 1a, 25-Dihydroxyvitamin D3<br>* Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by enzyme-linked immunoabsorbent assay.<br>|
| randomly age-matched people<br>Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by enzyme-linked immunoabsorbent assay and vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis in randomly age-matched people. | Other: Vitamin D receptor polymorphic analysis<br>* Vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis.<br>Other: Serum levels of 1a, 25-Dihydroxyvitamin D3<br>* Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by enzyme-linked immunoabsorbent assay.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum levels of 1a, 25-Dihydroxyvitamin D3 |  | 1 day visit | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| gene polymorphisms of vitamin D receptor |  | 1 day visit | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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vitamin D, primary open- angle glaucoma