The Effect of Preoperative Values on Mortality in Patients Undergoing Open Heart Surgery

Study Overview
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Brief Summary
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Open heart surgeries are one of the major and complicated surgeries performed frequently in the world due to the prolongation of life expectancy and developments in medicine. As a result of these operations, not only the heart and vessels, but also all organs and systems depending on the systemic circulation are affected. Some biological inflammation markers have been determinant in determining cardiovascular risk. High neutrophil count was associated with increased mortality, while low lymphocyte count was a strong constant predictor of mortality. In addition, increased serum uric acid (UA) levels have been found to be associated with obesity, dyslipidemia, and hypertension, which is associated with cardiovascular disease risk. The aim of this study is to investigate the effects of patients who underwent coronary bypass surgery under elective conditions in Karadeniz Technical University Faculty of Medicine between 2008-2020 on in-hospital and 1-year mortality based on preoperative neutrophil / lymphocyte ratios and uric acid values.

Detailed Description
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Open heart surgeries are one of the major and complicated surgeries performed frequently in the world due to the prolongation of life expectancy and developments in medicine. Mortality rates are decreasing day by day, although more and more additional diseases are present and older patients are taken in open heart surgery. The aim of these surgeries is to reduce the risk of death by correcting existing cardiac pathologies and increasing the quality of life of patients. For this reason, some studies have developed cardiac risk scoring methods in preoperative evaluation in order to predict mortality before surgery, and created a risky group such as advanced age, female gender, decreased left ventricular functions, those who use postoperative intraaortic balloon pumps, and those who receive inotrope support. Some biological inflammation markers have been determinant in determining cardiovascular risk. High neutrophil count was associated with increased mortality, while low lymphocyte count was a strong constant predictor of mortality. Cardiovascular bypass itself is related to neutrophil activation, highlighting the effects of its high preoperative levels. Increased neutrophil counts are related to blood viscosity and hypercoagulability. Also, decreased lymphocyte count indicates increased physiological stress. The importance of serum uric acid levels has been stated in many epidemiological studies as a risk factor for cardiovascular diseases. Increased serum uric acid (UA) levels are associated with obesity, dyslipidemia, and hypertension, which is associated with a risk of cardiovascular disease. In another study, it was shown that the risk of cardiovascular mortality and increased serum UA levels were independently and significantly related. The aim of this study was to examine the short-term (first 30 days) and long-term (1 year) mortality of patients who underwent elective coronary bypass surgery between 2008 and 2020 at the Karadeniz Technical University Faculty of Medicine, based on preoperative neutrophil / lymphocyte ratios and uric acid values. effects will be investigated

Official Title
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The Effect of Preoperative Neutrophil / Lymphocyte Ratio and Uric Acid Values on Short and Long Term Mortality in Patients Undergoing Open Heart Surgery

Conditions
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Mechanical Ventilation, Coronary Bypass Surgery, Postoperative Complications

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Elective patients undergoing open heart surgery Exclusion Criteria: Immunodeficiency Emergency operations Patients whose records could not be accessed and who were excluded from the study group procedure in which they were included for any reason will not be included in the study. Patients under 18 years of age

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| neutrophil / lymphocyte ratios | The effect on postoperative complications of preoperative neutrophil lymphocyte ratio in open heart surgery | postoperative 2 week | 
| neutrophil / lymphocyte ratios | The effect on mortality of preoperative neutrophil lymphocyte ratio in open heart surgery | postoperative 1 year | 
| uric acid values | The effect on mortality of preoperative uric acid values in open heart surgery | postoperative 1 year | 
| uric acid values | The effect on postoperative complications of preoperative uric acid values in open heart surgery | postoperative 2 week | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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neutrophil / lymphocyte ratios, uric acid level, mortality, coronary bypass surgery, Postoperative Complications