A Comfort Survey of Open-angle Glaucoma or Ocular Hypertension Patients Treated With 2 Drugs

Study Overview
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Brief Summary
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The objective of the study was to evaluate whether timolol hemihydrate is more comfortable upon instillation than timolol maleate in sorbate. This was an observational study. Subjects with open-angle glaucoma or ocular hypertension were asked to complete a survey regarding their normal treatment. No treatment was prescribed.

Official Title
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A Comfort Survey of Open-angle Glaucoma or Ocular Hypertension Patients Treated With Timolol Hemihydrate 0.5% Solution Once or Twice Daily Versus Timolol Maleate in Sorbate

Conditions
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Open-angle Glaucoma, Ocular Hypertension

Intervention / Treatment
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* Drug: timolol hemihydrate
* Drug: timolol maleate


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: willing to comply with investigator's and protocol's instructions patients signature on the informed consent document open-angle glaucoma or ocular hypertension currently prescribed timolol hemihydrate (once a day (QD) or twice a day (BID))or timolol maleate in sorbate QD as monotherapy or as a part of 2-drug therapy in at least one eye Exclusion Criteria: inability to understand the trial procedures inability to give informed consent inability to understand, read, or write English best corrected visual acuity of 20/200 or worse in each eye current moderate to severe infectious or inflammatory condition of the eye or eyelids including current moderate to severe dry eye syndrome current chronic use of ocular corticosteroids, ocular surgery or intraocular laser surgery to either eye in the prior 3 months treated with 3 or more glaucoma medicines in both eye

Ages Eligible for Study
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Minimum Age: 21 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Timolol hemihydrate<br>Subjects currently prescribed timolol hemihydrate 0.5% solution. | Drug: timolol hemihydrate<br>* timolol hemihydrate 0.5% solution<br>|
| Timolol maleate<br>Subjects currently prescribed timolol maleate in sorbate. | Drug: timolol maleate<br>* timolol maleate in sorbate<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Subject Reported Burning/Stinging | Subjects reported burning/stinging after they put the drops in their eyes using the following scale: 0=never, 1=rarely, 2=sometimes, 3=frequently, 4=always. | Upon instillation | 
| Subject Reported Tearing | Subjects reported tearing after they put the drops in their eyes using the following scale:0=never, 1=rarely, 2=sometimes, 3=frequently, 4=always. | Upon instillation. | 
| Subject Reported Light Sensitivity | Subjects reported light hurt their eyes after they put the drops in their eyes using the following scale: 0=never, 1=rarely, 2=sometimes, 3=frequently, 4=always. | Upon instillation | 
| Subject Reported Blurred Vision | Subjects reported their vision was blurred after they put the drops in their eyes using the following scale: 0=never, 1=rarely, 2=sometimes, 3=frequently, 4=always. | Upon instillation |