Acupuncture for Migraine: a Functional Magnetic Resonance Imaging (fMRI) Study

Study Overview
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Brief Summary
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Selecting acupoints along meridians is the predominant principle in acupuncture treatment, and it is also considered to ensure acupuncture efficacy. This experiment is to investigate whether specific brain networks gradually come in formation in accordance with this kind of acupoint selection methods.

Detailed Description
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Every participants in the four intervention groups will go through functional magnetic imaging (fMRI) scan four times: the 1st scan will be performed at their baselines; the 2nd scan will be done after 2 courses (10 times) acupuncture treatment; the 3rd scan will be performed when the 4 courses end; the 4th scan will be operated after three-month enrollment. Volunteers in waiting list group will undergo the above scans at the same time points in exception of acupuncture treatment.

Official Title
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Acupuncture Treatment for Migraine: a Functional Magnetic Resonance Imaging Study

Conditions
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Migraine

Intervention / Treatment
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* Other: manual acupuncture


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: clinical diagnosis of non-aura Migraine formulated by the international headache society in 2004 Exclusion Criteria: people with other types of headache people with organic cerebral disorders people with primary disorders people in moderate or severe anxiety or depression people in pregnancy

Ages Eligible for Study
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Minimum Age: 17 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: specific points of Bladder meridian and Shanjiao meridian<br>In traditional Chinese acupuncture theory, Bladder meridian and Shanjiao meridian have been considered as the main pathological meridian location of migraine. Meanwhile, specific points on both meridians have been used widely in its treatment for a long time. | Other: manual acupuncture<br>* thirty minutes duration every time, five times per week for one course, a total four courses<br>* Other names: acupuncture;|
| Experimental: non-specific points of Bladder meridian and Shanjiao meridian<br>Non-specific points of Shaoyang meridians are also used in cure of migraine. It is conventionally thought to be less effective using non-specific points than specific ones. | Other: manual acupuncture<br>* thirty minutes duration every time, five times per week for one course, a total four courses<br>* Other names: acupuncture;|
| Active Comparator: specific points of Stomach meridian<br>Specific points of Stomache meridian for migraine were searched in Chinese ancient data. And this group is set to compare with specific points of Shaoyang meridians for their possible different brain networks. | Other: manual acupuncture<br>* thirty minutes duration every time, five times per week for one course, a total four courses<br>* Other names: acupuncture;|
| Placebo Comparator: non-acupoints<br>Three non-acupoints were chosen,two of which were located on the arm and one one the leg. | Other: manual acupuncture<br>* thirty minutes duration every time, five times per week for one course, a total four courses<br>* Other names: acupuncture;|
| No Intervention: waiting list<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| improvement of headache frequency |  | 4 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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acupuncture, migraine, specific acupoints, brain network