Prevalence of Sensitization to Legumes in a Region From Southern France (Légumineuses)

Study Overview
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Brief Summary
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The Mediterranean diet is a model for health. Indeed, according to some epidemiological studies, it would participate in the prevention of various diseases such as cardiovascular diseases, diabetes type 2, cancer and obesity. Among the foods composing the Mediterranean diet, wheat and legumes are strongly represented. The introduction of legumes into an easily prepared and economical food for a large part of the population will lead to an increase in consumption. The combination of durum wheat semolina and legume flour would benefit from the nutritional qualities of the two raw materials (high protein, slow digestible carbohydrates, fiber, vitamins and minerals), but also of their double wheat-legume allergenicity.

Official Title
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Analyis of the Prevalence of Sensitization to Legumes by Realistic Skin Prick Tests in a Patient Population Consulting at the University Hospital of Montpellier

Conditions
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Sensitization to Legumes

Intervention / Treatment
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* Other: Skin prick tests with four native legumes


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients seen in allergy consultation The patient (or parents for the under 18 years) must have given their free consent and signed the consent chart Men and women are included The patient is at least 2 years old Exclusion Criteria: The patient is pregnant The patient is breast-feeding The patient is unable to stop in antihistamine medication for at least 7 days The patient refused or is unable to sign the consent chart The patient has a dermographism

Ages Eligible for Study
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Minimum Age: 2 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Experimental<br>Skin prick tests with four native legumes | Other: Skin prick tests with four native legumes<br>* Skin prick tests with four native legumes<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sensitization rate to four cooked legumes in the population consulting in Allergy Unit at the University Hospital of Montpellier | A prick test will be considered as positive in the presence of a wheal of urticaria of at least 3 mm in size | 10 minutes (the average duration of the test will not be significantly increased) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Describe the population with positive skin prick tests to legumes | A prick test will be considered as positive in the presence of a wheal of urticaria of at least 3 mm in size | 5 years | 
| Associations between symptoms on ingestion of these legumes | Association between the positivity of the legume prick test and (1) symptoms upon ingestion of legumes (e.g., aracid and other fruits and vegetables), (2) symptoms of rhinitis, asthma, atopic eczema, and (3) positivity to other prick tests of the standard pneumallergen battery | 5 years |