Effects of Unilateral WBV on Muscleactivity of Contralateral Hip Adductor

Study Overview
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Brief Summary
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The aim of this study is to investigate effects of femur exposed to unilateral vibration on the rest muscle electrical activity of contralateral hip adductors and contralateral soleus H-reflex in young adult men. This study hypothesize that femur exposed to unilateral vibration may affect the rest muscle electrical activity of contralateral hip adductors. Vibration can effectively enhance muscle strength and power. Previous studies have shown that vibration increases muscle electromyographic (EMG) activity. It has been showed that bone has an effect on the increase in muscle EMG activity caused by vibration in healthy young adults in a study. In this study, it was reported that vibrations-induced increases in muscle electrical activity of flexor carpi radialis (FCR) was related to ultradistal radius bone mineral content (BMC) and the FCR H-reflex was suppressed or depressed during vibration. This findings were reported to support the assumption that the bone exposed to cyclic mechanical loading may neuronally regulate muscle activity.

Detailed Description
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A total of 20 voluntaries are planned to include in this study. Vibration will be applied the right lower extremity by whole-body vibration (PowerPlate Pro). Cases will stand on vibration plate. WBV will be applied at a frequency of 40 Hz and amplitude of 2 mm for 60 seconds. WBV will be applied one session only. The rest muscle electrical activity of ipsilateral and contralateral hip adductor muscles at rest will be measured by PowerLab (data acquisition system, ADInstruments, Australia) device.The rest-EMGrms will be measured at before and during vibration. We also evaluate a change in contralateral soleus H reflex during vibration. Effects of bone on the rest muscle electrical activity will be assessed by hip bone mineral density, bone mineral content and serum sclerostin level. The right hip bone mineral density (BMD) and BMC will be evaluated by bone densitometer (Norland). Plasma sclerostin level will be measured by using Human Sclerostin ELISA kıt before and after vibration.

Official Title
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The Effects Of Femur On The Resting Myoelectrical Activity Of Contralateral Adductor Muscle During Unilateral Lower Extremity Vibration: Bone Myoregulation Reflex

Conditions
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Bone Mass, Effects of Vibration

Intervention / Treatment
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* Other: Whole-body vibration


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age: 20-40 yrs Gender: Male Volunteer Healthy status: Patients having hypoesthesia in his leg and Healthy subjects Dominant hand:Right-handed Exclusion Criteria: Bone diseases (osteoporosis, osteomalacia, paget's disease, neoplasm, etc), Systemic diseases (cardiovascular, endocrine, infections etc), Myopathy-tendinopathy Lower limb joint disease Vertigo Obesity (BMI >30 kg/m2) Professional sportsman Male doing regular sports activities Skin disease in lower limb Non-cooperative subject Hemolysis of blood sample

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Whole-body vibration<br>whole body vibration will be applied the right lower limb. | Other: Whole-body vibration<br>* Frequency: 40 Hz, vibration amplitude: 2 mm, duration: 60 sec<br>* Other names: Cyclic mechanical loading;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vibration-induced contralateral muscle electrical activity |  | 3 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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bone, osteocyte, rest muscle electrical activity, whole-body vibration, sclerostin