Characterization of Peripheral Muscle Function in Patients With Non-small-cell Lung Cancer

Study Overview
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Brief Summary
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Rationale: With 1.6 million new cases diagnosed each year and 1.3 million deaths, lung cancer is the leading cancer-related death worldwide and it represents a pressing health issue. Patients with lung cancer are more likely to experience cachexia, a severe debilitating disorder causing fatigue, weight loss, muscle wasting and associated with reduced physical function, increased chemotherapy toxicity and reduced survival. This syndrome occurring in about 80% of advanced cancer patients is the direct cause of death in about 20% of cases. However, despite the importance of cachexia in lung cancer, its mechanisms ans its relation with muscle function and effort tolerance are still unknown. Aim: To explore muscle function, signaling pathways and its relationship to impaired functional capacity of patients with non-small-cell lung cancer(NSCLC); depending of whether they have cachexic state at diagnosis. Methods: This study will be conducted at the Institut universitaire de cardiologie et de pneumologie de Québec. 56 patients newly diagnosed of NSCLC will be recruited and separated whether or not they have a cachexic state. The evaluation will need two visits separated by 5 days. During the evaluation the following tests will be done: Anthropometric measures Level of daily physical activity Pulmonary function test Maximal incremental cardiopulmonary exercise test on ergocycle Endurance test on ergocycle Muscle function tests Magnetic stimulation Quadriceps biopsy

Official Title
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Characterization of Peripheral Muscle Function in Patients With Non-small-cell Lung Cancer.

Conditions
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Non-Small-cell Lung Cancer

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men and women with a primary lung cancer diagnosis Exclusion Criteria: Already have undertaken surgery, chemotherapy or radiotherapy treatment Having an other cancer in the last five years Taking anticoagulation therapy

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Lung cancer patient with cachexia<br>Muscle lumbar area < 55cm2/m2 for men and < 39 cm2/m2 for women | |
| Lung cancer patients without cachexia<br>Muscle lumbar area over 55cm2/m2 for men and 39 cm2/m2 for women | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximal quadriceps strength |  | 1 day (at the time of the diagnosis before any treatment) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Exercise capacity |  | 1 day (at the time of the diagnosis before any treatment) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Biopsy, Maximal incremental cardiopulmonary test, Muscle strength test, magnetic stimulation