The Effects of Hemodialysis Session on Vascular Stiffness

Study Overview
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Brief Summary
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Central blood pressure and pulse wave velocity were measured using a Complior Analyse device before and immediately after the end of the dialysis session.

Official Title
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The Effects of Hemodialysis Session on Pulse Wave Velocity and Central Arterial Pressure

Conditions
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Arteriopathic Disease, Arterial Calcification, Complication of Hemodialysis, Aortic Stiffness

Intervention / Treatment
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* Device: Complior Analyse System
* Device: BCM- Body Composition Monitor


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: give voluntary consent to participate in the study patients on maintenance hemodialysis at least 3 months stable dry weight single-pool Kt/V >1.4 no clinical cardiovascular disease during the 6 months preceding entry medical staff (medical doctors, nurses) Exclusion Criteria: not meet the above criteria episode of illness (for example: infection) pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hemodialysis patients<br>Stable end-stage renal disease patients on maintenance conventional hemodialysis received 4-5 hours of treatment thrice weekly. Pulse wave velocity and central aortic pressure was measured before and after the midweek dialysis session.Overhydration Urea distribution volume (V) Total body water, extracellular and intracellular water Lean Tissue Index (LTI) Fat Tissue Index (FTI) Body Cell Mass (BCM) was measured before the midweek dialysis session just after Complior device | Device: Complior Analyse System<br>* Pulse Wave Velocity PWV and central Pressure analysis<br>Device: BCM- Body Composition Monitor<br>* BCM - Body Composition Monitor gives information about: Overhydration Urea distribution volume (V) Total body water, extracellular and intracellular water Lean Tissue Index (LTI) Fat Tissue Index (FTI) Body Cell Mass (BCM)<br>|
| Healthy subjects<br>Medical staff: medical doctors, nurses | Device: Complior Analyse System<br>* Pulse Wave Velocity PWV and central Pressure analysis<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differences in carotid-femoral pulse wave velocity [m/s] just before and after hemodialysis session |  | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differences in central aortic pressure [mmHg] just before and after hemodialysis session |  | 1 day | 
| Differences in central aortic pressure [mmHg] and cuff blood pressure [mmHg] just before and after hemodialysis session |  | 1 day | 
| Impact of fluid and nutritional status on carotid-femoral pulse wave velocity and central aortic pressure |  | 1 day |