Pharmacokinetics of Epinephrine During Cardiac Arrest

Study Overview
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Brief Summary
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To determine the pharmacokinetics of epinephrine during cardiac arrest.

Detailed Description
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The aim of out study is to determine the pharmacokinetics in humans during cardiac arrest, following a single dose of epinephrine. Venous samples will be withdrawn every minute the first five minutes following a single dose. The aim of the study is to determine T1/2 in a clinical setting and to determine time to peak concentration.

Official Title
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Pharmacokinetic Study of Epinephrine During Cardiac Arrest Determining T1/2 and Time to Peak Concentration

Conditions
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Cardiac Arrest

Intervention / Treatment
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* Drug: Epinephrine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18-85 yrs Witnessed non-traumatic cardiac arrest. Probable cardiac origin Treated by Bergen Emergency Medical Services Exclusion Criteria: Terminal illness Residents of nursery homes Obvious dead Hypothermic patients Epinephrine administered before arrival of study physician

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| one group<br>All patients treated for cardiac arrest, meeting our inclusions criteria will be enrolled in the study. No interventions regarding the national guidelines will be jeopardized, as the plasma concentration following a single dose of epinephrine will be measured in all patient. | Drug: Epinephrine<br>* This is truly an observational study to determine T1/2 for epinephrine and time to peak concentration following a single dose of epinephrine in a cardiac arrest setting<br>* Other names: Adrenaline;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Concentration of epinephrine (ng/mL) as a function of time the first five minutes following administration | Blood concentration of epinephrine will be determined the first five minutes following administration. For every minute starting With administration of epinephrine, blood samples will be drawn to determine the concentration (ng/mL). In total, six samples will be drawn. The administered dose (1 mg) will also be related to the patients weight, either estimated, or for those survivors admitted to hospital, measured in the Intensive Care Unit. Further, data according to the Utstein-template will be recorded.However, the primary outcome is to determine the plasma concentrations in every patients the first five minutes. | Blood samples will be drawn within minutes, and the survivors transported to hospital. The data according to Utstein-style, will also be collected. Blood samples will be analysed within weeks.Total timeframe for the study is estimated to one year. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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epinephrine