Assessment of the Possible Association Between Left Ventricular Diastolic Dysfunction and Carotid Atherosclerosis and Brain White Matter Damage

Study Overview
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Brief Summary
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Left ventricular diastolic dysfunction is caused by impaired relaxation and increased left ventricular stiffness with a consequent increase in filling pressures. Currently, it is possible to classify it in 3 grades: grade 1 with normal filling pressures, grade 2 and grade 3 with high pressures. Diastolic dysfunction is closely associated with several risk factors such as hypertension, diabetes, and obesity, as well as the risk of heart failure, cardiovascular events, and death. In the field of cerebrovascular diseases, however, diastolic dysfunction is still being researched. Thus, this study aims to: 1) evaluate the white matter hyperintensities volume in association with the increase of diastolic dysfunction and filling pressures 2) evaluate the possible association with carotid atherosclerosis in case of brain damage caused by dysfunction diastolic 3) understand the mechanism of damage caused by left ventricular diastolic dysfunction on the cerebrovascular system. In order to do this, this study proposes to evaluate in a cohort of patients, between 35 and 65 years, the possible association of diastolic dysfunction with lesions on the cerebrovascular system in a future view of new marker of brain damage and new modifiable risk factor.

Official Title
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Assessment of the Possible Association Between Left Ventricular Diastolic Dysfunction and Carotid Atherosclerosis and Brain White Matter Damage

Conditions
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Left Ventricular Diastolic Dysfunction

Intervention / Treatment
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* Other: No interventions


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age ≥ 35 and ≤ 65 years written informed consent Exclusion Criteria: previous stroke or TIA arrhythmia or severe cardiac disease renal disease psychiatric disease neurological or neurodegenerative disease dementia previous carotid artery stenting or carotid surgery inability to be subjected MRI analysis

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with grade 2 and 3 LV diastolic dysfunction<br>Patients with high filling pressure | Other: No interventions<br>* No interventions - observational study<br>|
| Patients with normal and grade 1 LV diastolic dysfunction<br>Patients with normal filling pressure | Other: No interventions<br>* No interventions - observational study<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of white matter hyperintensities volume | Brain MRI | At Enrollment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Detection of plaques and carotid atherosclerosis | Ultrasound of the supraortic trunks | At Enrollment | 
| Characterization of cardiac overload with blood markers | NT-proBNP | At Enrollment | 
| Detection of cognitive decline by decrease of MoCA score | Cognitive tests | At Enrollment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Diastolic dysfunction, White matter hyperintensities, Carotid atherosclerosis