Outcome of Cardiac Arrest Survivors

Study Overview
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Brief Summary
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Early prognosis of cardiac arrest - nearly 40000 new cases per year in France - has been extensively studied, highlighting a poor outcome (less than 8% at hospital discharge). However, little is known on mid and long-term prognostic factors and how these patients do survive from the event. Using a regional cohort, the aim of the study is to describe long-term survival rate of cardiac arrest survivors, and to assess the influence of treatment strategies on survival and functional outcome.

Detailed Description
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The collection of clinical and biological data of patients who experienced cardiac arrest and survive from hospital, including a regular follow-up with qualitative data (functional, neurological and quality of life) may provide important benchmark on the evolution of these patients and on the impact of acute interventions (such as cardio-pulmonary resuscitation, defibrillation, emergent coronary revascularization, neuroprotective treatments). Using a large identified cohort of survivors of cardiac arrest, we aim to describe the qualitative long-term prognosis of these cardiac arrest patients (functional, neurological and quality of life status). Secondarily, we intend to identify the long-term prognostic factors, and particularly the role of early interventions, using a long-term and qualitative combined endpoint (vital status, functional scales, SF36). This project is observational and will include all patients over 18 admitted alive after non-traumatic cardiac arrest in the area of Ile-de-France (France), whatever the cause of the cardiac arrest. Patients or their proxies, refusing their participation, will not be included. We will collect all pre- and in-hospital information related to the event and performs prospectively interviews at 3 months and every year anniversary. The questionnaire will include vital status, cardiovascular events, medication and a complete qualitative report (SF36, ADL scale, OPC, CPC, social-professional activities). This project will provide important data over time on the evolution of these patients. Findings will help in measuring the role of different strategies on long-term prognosis and consequently improve the overall management of cardiac arrest.

Official Title
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Outcome of Cardiac Arrest Survivors: Prospective Cohort of Ile-de-France

Conditions
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Cardiac Arrest Survivors

Intervention / Treatment
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* Other: Long-term follow-up


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients alive after resuscitation from a out-of-hospital cardiac arrest All causes for cardiac arrest Age above 18 Informed consent from the patient or next of kin Exclusion Criteria: Impossibility for communication after hospital discharge, whatever the cause (language, residence…) Follow-up refusal from the patient or next of kin

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| French prospective cohort of cardiac arrest survivors<br>Outcome of cardiac arrest survivors: prospective cohort of Ile-de-France | Other: Long-term follow-up<br>* Vital and neurological follow-up<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cerebral Performance Categories Scale | Combined vital and neurological status | at last follow-up (48 months max) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| SF-36 (Short-Form General Health Survey) | Quality of life | at last follow-up (48 months max) | 
| Overall Performance Categories (OPC) |  | at last follow-up (48 months max) | 
| Activities of Daily Living (ADL) scale |  | at last follow-up (48 months max) | 
| New cardiovascular events |  | at last follow-up (48 months max) | 
| New York Heart Association (NYHA) status |  | at last follow-up (48 months max) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cardiac arrest, outcome, neurological status