Study of Seroprevalence of Anti-SARS-CoV2 Among Children of Hospital Workers in AP-HP

Study Overview
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Brief Summary
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The purpose of this study is to define seroprevalence of anti-SARS-CoV2 among children of Hospital Workers in APHP, particularly exposed population, according to parents' SARS-CoV2 serological status.

Official Title
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Seroprevalence of Anti-SARS-CoV2 Among Children According to Parents' SARS-CoV2 Serological Status. Study in a Hospital Population Assistance Publique-Hôpitaux Paris

Conditions
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SARS-CoV2

Intervention / Treatment
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* Biological: Serology SARS-CoV2
* Behavioral: Data collection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Hospital workers : Individuals aged over 18, having a professional activity at the APHP (employees, interns, volunteers) Affiliated to a social security regimen Have at least one child under the age of 18 living in the same house. have signed consent Child (ren), spouse and other member (s) residing at household: Child (ren), spouse and any other member residing in the household of a professional of the Paris Center Hospitals meeting the inclusion criteria above. Exclusion Criteria: Refuse to participate in research
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: Serology SARS-CoV2|Collect serum for Serology SARS-CoV2 at inclusion|
|Behavioral: Data collection|Collect clinical and demographic data, habitus, Lifestyle Counseling at inclusion|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Seroprevalence of antibodies anti- SARS Cov2 in blood sample of children of Hospital workers | Percentage of children with seropositive in blood sample according to parents' SARS Cov2 serological status | at inclusion | 
| Seroprevalence of antibodies anti- SARS Cov2 in saliva sample of children of Hospital workers | Percentage of children with seropositive according in saliva sample to parents' SARS Cov2 serological status | at inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Asymptomatic Children with a positive seroloy |  | At inclusion | 
| Number of severely symptomatic Children with a positive serology |  | At inclusion | 
| Prevalence of different clinical symptoms in children with a positive serology |  | At inclusion | 
| Serological result of each member of the family |  | At inclusion | 
| Number of spouses of hospital workers with a positive serology |  | At inclusion | 
| Number of Asymptomatic spouses of hospital workers with a positive serology |  | At inclusion | 
| Number of severely symptomatic spouses of hospital workers with a positive serology |  | At inclusion | 
| Comparison of Serological result obtained in blood and saliva samples |  | At inclusion | 
| Risk factors based on a questionnaire for children and adults | the following factors will be of particular importance: characteristics and composition of the family home, barrier measures, medical history and comorbidities. | At inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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SARS-CoV2, COVID-19, Serology, Hospital workers, Children