Effect of Interval Training on Arterial Stiffness in Women With Hypertension

Study Overview
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Brief Summary
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this study is aiming to assess the chronic effect of the interval training program on arterial stiffness in women with hypertension

Official Title
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Effect of Interval Training on Arterial Stiffness in Women With Hypertension

Conditions
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Arterial Stiffness

Intervention / Treatment
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* Other: interval training exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: physically inactive BMI 30-40 Stage 1 and 2 hypertension Elevated BP as systolic BP ≥130 mm Hg and/or diastolic BP ≥85 mm Hg measured at the brachial artery. Exclusion Criteria: Medications known to affect weight or appetite Any disease associated with exercise intolerance. Women were taking hormone replacement therapy

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: interval training<br>Aerobic interval training. It consisted of a modified interval cycle ergometer training program (3 days a week for 8 weeks). AIT consisted of 8 min warm up, followed by four times of 4-min intervals with HR at 80% of submaximal predetermined HR, with active phases of 3 min of cycling at 60% of submaximal predetermined HR. The exercise session was terminated by 5 min cool down | Other: interval training exercise<br>* interval training exercise<br>|
| No Intervention: medical treatment<br>hypertensive medication | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Central arterial stiffness measurements (Pulse Wave Velocity [PWV], augmentation index ) | Pulse wave analysis (PWA) of the women in the two groups: pre and post treatment for pulse wave velocity (PWV) and augmentation index(AIx) Pulse Wave Velocity [PWV], augmentation index (AIx @75HR) and resting heart rate were measured using analysis equipment which called Non-invasive blood pressure measurement system using Mobil-O-Graph 24h PWA  with Hypertension Management Software Client Server (HMS-CS 4.3). PWA was performed using an oscillometric Mobil-O-Graph R 24 h PWA Monitor device (I.E.M GmbH, Germany) with integrated ARCSolver® software | two months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| blood lipid profile | blood analysis will be used to measure lipid profile (high and low-density lipoprotein, cholesterol, triglyceride) | two months | 
| interleukin 6 | blood analysis will be used to measure interleukin 6 | two months | 
| blood pressure (systolic and diastolic) | resting Blood pressure was monitored from the right arm using an automated digital electronic BP monitor (Omron digital BP monitor, Model 11 EM 403c; Tokyo Japan). | two months |