Study to Determine the Safety and Efficacy of Ribociclib in Combination With Hormone Therapy and Hypofractionated Radiotherapy in Breast Cancer, With Positive Hormone Receptors and Negative HER2 Status, in Newly Diagnosed, Not Immediately Operable Elderly Patient (CALHYS)

Study Overview
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Brief Summary
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Women aged 70 years or older, newly diagnosed for locally advanced unilateral breast cancer, with a histological diagnosis of invasive mammary carcinoma, positive hormone receptors, HER2 status Negative, not immediately operable (stage of disease, comorbidities or refusal of surgery) with tumor in place, with indication of treatment with hormone therapy and hypofractionated radiotherapy, not eligible for neoadjuvant chemotherapy and without major comorbidity contraindicating the proposed treatment regimen.

Official Title
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Phase I/II Study to Determine the Safety and Efficacy of Ribociclib in Combination With Hormone Therapy and Hypofractionated Radiotherapy in Breast Cancer, With Positive Hormone Receptors and Negative HER2 Status, in Newly Diagnosed, Not Immediately Operable (or Refusal of Surgery), Elderly Patient (CALHYS)

Conditions
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HER2 Negative Breast Cancer Not Immediately Operated

Intervention / Treatment
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* Drug: Ribociclib Oral Tablet


Participation Criteria
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Eligibility Criteria
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Criteria for registration phase Inclusion criteria Written informed consent must be obtained prior to any screening procedures; Women ≥ 70 years old at the time of signing informed consent; Have a performance status of 0 to 2 on the ECOG Performance Scale ; Newly diagnosed for non-metastatic unilateral breast cancer; Histological diagnosis of invasive mammary carcinoma, positive hormone receptors, HER2 status Negative defined as a negative in situ hybridization test or an IHC status of 0, 1+ or 2+. If IHC is 2+, a negative in situ hybridization (FISH, CISH, or SISH) test is required by local laboratory testing and based on the most recently analyzed tissue sample; Not immediately operable (stage of disease, comorbidities or refusal of surgery) with tumor in place; Measurable disease based on RECIST 1.1 (a lesion at a previously irradiated site may only be counted as a target lesion if there is a clear sign of progression since the irradiation). Demonstrate adequate organ functions: Hemoglobin > 9 g/dL; Absolute neutrophil count > 1.5 G/L; Platelets > 100 G/L; INR ≤1.5 (unless the patient is receiving anticoagulants and the INR is within the therapeutic range of intended use for that anticoagulant within 7 days prior to the first dose of study drug); Total serum bilirubin < ULN; or total bilirubin ≤ 3.0 × ULN or direct bilirubin ≤ 1.5 × ULN in patients with well documented Gilbert's Syndrome AST and ALT < 2.5 x ULN; Alkaline Phosphatase < 2.5 x ULN Calculated creatinine clearance > 30 ml/min using MDRD formula; Patient must have the following laboratory values within normal limits or corrected to within normal limits with supplements (the local laboratory value should be documented within normal limits after the correction) before registration: Potassium Magnesium Total Calcium (corrected for serum albumin); Standard 12-lead ECG values defined as the mean of the triplicate ECGs QTcF interval at screening < 450 msec (QT interval using Fridericia's correction) Mean resting heart rate 50-90 bpm (determined from the ECG) Indication of treatment with hormone therapy and hypofractioned radiotherapy; Patients having taken cognizance of the information sheet and having signed the informed consent; Patients covered by medical insurance. Must be able to swallow ribociclib; Subjects must be able to communicate with the investigator and comply with the requirements of the study procedures; Must be willing to remain at the clinical site as required by the protocol. Exclusion criteria Patient eligible to resection surgery and agreed to proceed with the surgery; Patient eligible to neoadjuvant chemotherapy; Patient with distant metastases of breast cancer beyond regional lymph nodes (stage IV according to AJCC 8th edition); Concomitant bilateral breast cancer; Previous treatment, in the 2 years before inclusion, by chemotherapy, hormone therapy, thoracic surgery or radiotherapy for a malignant tumor; Tumor in previously irradiated territory; Patient has received any CDK4/6 inhibitor; Patient with a known hypersensitivity to any of the excipients of Ribociclib and/or hormono therapy (e.g. rare hereditary problems of galactose intolerance, the Lapp lactase deficiency, glucose-galactose malabsorption, and soy allergy); Known additional malignancy. Exceptions include basal cell carcinoma of the skin or in situ cervical cancer that has undergone potentially curative therapy; Contraindication for hormone therapy , Ribociclib or radiotherapy; Severe dementia; Patient has had major surgery within 14 days prior to starting study drug or has not recovered from major side effects. Patient has any other concurrent severe and/or uncontrolled medical condition that would, in the investigator's judgment, cause unacceptable safety risks, contraindicate patient participation in the clinical study or compromise compliance with the protocol: (e.g., chronic pancreatitis, chronic active hepatitis, active untreated or uncontrolled fungal, bacterial or viral infections, etc.) Clinically significant, uncontrolled heart disease and/or cardiac repolarization abnormality, including any of the following: History of documented myocardial infarction (MI), angina pectoris, symptomatic pericarditis, or coronary artery bypass graft (CABG) within 6 months prior to study entry Documented cardiomyopathy Left Ventricular Ejection Fraction (LVEF) < 50% as determined by Multiple Gated acquisition (MUGA) scan or echocardiogram (ECHO) Long QT syndrome or family history of idiopathic sudden death or congenital long QT syndrome, or any of the following: Risk factors for Torsades de Pointe (TdP) including uncorrected hypocalcemia, hypokalemia or hypomagnesemia, history of cardiac failure, or history of clinically significant/symptomatic bradycardia Concomitant medication(s) with a known risk to prolong the QT interval and/or known to cause Torsades de Pointe that cannot be discontinued or replaced by safe alternative medication (e.g., within 5 half-lives or 7 days prior to starting study drug) Inability to determine the QTcF interval Clinically significant cardiac arrhythmias (e.g., ventricular tachycardia), complete left bundle branch block, high-grade AV block (e.g., bifascicular block, Mobitz type II and third degree AV block) Systolic Blood Pressure (SBP) >160 or <90 mmHg Patient is currently receiving any of the following substances within 7 days before randomization: Concomitant medications, herbal supplements, and/or fruits (e.g. grapefruit, pomelos, starfruit, Seville oranges) and their juices that are known as strong inhibitors or inducers of CYP3A4/5; Medications that have a narrow therapeutic window and are predominantly metabolized through CYP3A4/5; Vulnerable persons as defined by article L1121-5 - 8: Pregnant women, women in labor or breast-feeding mothers, persons deprived of their freedom by judicial or administrative decision, persons hospitalized without their consent by virtue of articles L. 3212-1 and L. 3213-1 and who are not subject to the provisions of article L. 1121-8 Persons admitted to a social or health facility for reasons other than research; Adults subject to a legal protection order or unable to give their consent. Concurrent enrolment in another clinical trial using an investigational anti-cancer treatment within 28 days prior to the first dose of study treatment. Criteria for the Ribociclib and Radiotherapy concomitant phase Inclusion criteria Patient registered in the study-screening phase; Patient receiving, during the registration phase, 3 cycles of Ribociclib at 600mg without dose decreased; Have a performance status of 0 to 2 on the ECOG Performance Scale; Not immediately operable (stage of disease, comorbidities or refusal of surgery) with tumor in place; Measurable disease based on RECIST 1.1; Demonstrate adequate organ functions: Hemoglobin > 9 g/dL; Absolute neutrophil count > 1.5 G/L; Platelets > 100 G/L; INR ≤1.5 (unless the patient is receiving anticoagulants and the INR is within the therapeutic range of intended use for that anticoagulant within 7 days prior to the first dose of study drug); Total serum bilirubin < ULN; or total bilirubin ≤ 3.0 × ULN or direct bilirubin ≤ 1.5 × ULN; in patients with well documented Gilbert's Syndrome; AST and ALT <2.5 x ULN; Alkaline Phosphatase < 2.5 x ULN Calculated creatinine clearance > 30 ml/min using MDRD formula; Patient must have the following laboratory values within normal limits or corrected to within normal limits with supplements (the local laboratory value should be documented within normal limits after the correction) before inclusion: Potassium Magnesium Total Calcium (corrected for serum albumin); Standard 12-lead ECG values defined as the mean of the triplicate ECGs QTcF interval at screening < 450 msec (QT interval using Fridericia's correction) Mean resting heart rate 50-90 bpm (determined from the ECG)Indication of treatment with hormone therapy and hypofractioned radiotherapy; Patients having taken cognizance of the information sheet and having signed the informed consent; Patients covered by medical insurance. Must be able to swallow ribociclib; Subjects must be able to communicate with the investigator and comply with the requirements of the study procedures; Must be willing to remain at the clinical site as required by the protocol. Exclusion criteria Patient eligible to resection surgery after 3 cycles of Ribociclib; Patient eligible to neoadjuvant chemotherapy; Concomitant bilateral breast cancer; Known additional malignancy. Exceptions include basal cell carcinoma of the skin or in situ cervical cancer that has undergone potentially curative therapy; Contraindication for hormone therapy, Ribobociblib or radiotherapy; Patient has any other concurrent severe and/or uncontrolled medical condition that would, in the investigator's judgment, cause unacceptable safety risks, contraindicate patient participation in the clinical study or compromise compliance with the protocol: (e.g., chronic pancreatitis, chronic active hepatitis, active untreated or uncontrolled fungal, bacterial or viral infections, etc.) Clinically significant, uncontrolled heart disease and/or cardiac repolarization abnormality, including any of the following: History of documented myocardial infarction (MI), angina pectoris, symptomatic pericarditis, or coronary artery bypass graft (CABG) within 6 months prior to study entry Documented cardiomyopathy Left Ventricular Ejection Fraction (LVEF) < 50% as determined by Multiple Gated acquisition (MUGA) scan or echocardiogram (ECHO) Long QT syndrome or family history of idiopathic sudden death or congenital long QT syndrome, or any of the following: Risk factors for Torsades de Pointe (TdP) including uncorrected hypocalcemia, hypokalemia or hypomagnesemia, history of cardiac failure, or history of clinically significant/symptomatic bradycardia Concomitant medication(s) with a known risk to prolong the QT interval and/or known to cause Torsades de Pointe that cannot be discontinued or replaced by safe alternative medication (e.g., within 5 half-lives or 7 days prior to starting study drug) Inability to determine the QTcF interval Clinically significant cardiac arrhythmias (e.g., ventricular tachycardia), complete left bundle branch block, high-grade AV block (e.g., bifascicular block, Mobitz type II and third degree AV block) Systolic Blood Pressure (SBP) >160 or <90 mmHg Severe dementia; Patients unable to express their consent; Vulnerable persons as defined by article L1121-5 - 8: Pregnant women, women in labor or breast-feeding mothers, persons deprived of their freedom by judicial or administrative decision, persons hospitalized without their consent by virtue of articles L. 3212-1 and L. 3213-1 and who are not subject to the provisions of article L. 1121-8; Persons admitted to a social or health facility for reasons other than research; Adults subject to a legal protection order or unable to give their consent. Concurrent enrolment in another clinical trial using an investigational anti-cancer treatment.

Ages Eligible for Study
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Minimum Age: 70 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Sequential Assignment
Interventional Model Description: step 1 : 600mg of ribociclib step 2 : 400mg of ribociclib step 3 : 200mg of ribociclib
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Principal arm<br>registration phase : 3 cycles of 600mg per day of ribociclib Treatment phase : 3 cycles of dose de-escalation of ribociclib (600 or 400 or 200mg per day) Maintenance phase : 600mg per day of ribociclib until 24months of total treatment | Drug: Ribociclib Oral Tablet<br>* 600mg per day during registration phase (3 cycles); de-escalation phase (600 to 200mg per day associated to radiotherapy) during 3 other cycles; maintenance phase until 24 months of treatment in total (600mg per day). All over th etimme, hormonotherapy is received in concomitance<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Phase I : determination of Maximal Tolerated Dose (MTD) and the Recommended Phase II Dose (RP2D) of Ribociclib | Phase I : the frequencies of adverse events according to the CTCAE 4.03 requiring a dose discontinuation (DLT) will be determined during the 8 weeks of radiotherapy concomitant with the Ribociclib and hormone therapy and during the 3 months of post-radiotherapy follow-up. | Phase I : during the 8 weeks of radiotherapy concomitant with the Ribociclib and hormone therapy and during the 3 months of post-radiotherapy follow-up. | 
| Phase II : evaluation of the efficacy of Ribociclib in association with hormone therapy and hypofractionated radiotherapy | Phase II :The primary endpoint will be the rate of non-progression at 24-months, defined as the percentage of patients who are alive and have not progressed 24 months after the completion of the Ribociclib and Radiotherapy concomitant phase. | Phase II : at 24-months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| overall tolerance of ribociclib usin V4.03 Common Terminology Criteria for Adverse Events scale | The overall tolerance of Ribociclib during ribociclib monotherapy treatment and concomitant ribociclib radiotherapy treatment will be evaluated using clinical and biological assessment and graded according to the V4.03 scale. | up to 3 months following the last dose of radiotherapy | 
| overall survival | Evaluate overall survival (OS) | 24 months | 
| overall survival | Evaluate overall survival (OS) | 60 months | 
| progression free survival | Evaluate progression free survival (PFS) | 24 months | 
| progression free survival | Evaluate progression free survival (PFS) | 60 months | 
| quality of Life (European Organisation for Research and Treatment of Cancer quality of life questionnaire C30) | Evaluate quality of Life (items values from 1 to 4 per question) | 60 months | 
| quality of Life (ELDERLY CANCER PATIENTS14) | Evaluate quality of Life (items values from 1 to 4 per question) | 60 months | 
| compliance to Ribociclib | The treatment compliance will be assessed with the 8-item Morisky Medication Adherence Scale (score from 0 to 8) | 24 months | 
| medical health status | Evaluate the medical health status of the patients with the questionnaire G8, clinical score and visual analog scale for pain severity measurement (score from 0 to 17) | 60 months | 
| psychosocial health status | Evaluate the psychosocial status of the patients with GDS 4 questionnaire (score from 0 to 4) | 60 months | 
| functional health status | Evaluate the functional status of the patients with the questionnaires MINI MENTAL STATE EXAMINATION (score from 0 to 30) | 60 months | 
| functional health status | Evaluate the functional status of the patients with the questionnaires Autonomy Daily Living (score from 0 to 6) | 60 months | 
| functional health status | Evaluate the functional status of the patients with the questionnaires (Instrumental Activities in Daily Living (score from 0 to 8) | 60 months | 
| functional health status | Evaluate the functional status of the patients with the questionnaires walking speed | 60 months | 
| functional health status | Evaluate the functional status of the patients with the questionnaires percentage of weight loss | 60 months | 
| functional health status | Evaluate the functional status of the patients with Handgrip strength evaluation | 60 months |