Expanded Access to Voxelotor for Patients With Sickle Cell Disease Who Have No Alternative Treatment Options

Study Overview
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Brief Summary
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The intent of this open-label, multicenter expanded access program (EAP) is to provide early access to voxelotor prior to market authorization

Detailed Description
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The purpose of this program is to provide early access to voxelotor for patients with sickle cell disease who have exhausted alternative treatment options and are ineligible for actively-recruiting clinical trials of voxelotor. This EAP may continue until such time that voxelotor is commercially available or the Sponsor discontinues the voxelotor EAP. Discontinuation may occur earlier if an individual participant or physician or Sponsor Medical Monitor decides to discontinue treatment.

Official Title
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An Open-Label, Expanded Access Protocol for Patients With Sickle Cell Disease Who Have No Alternative Treatment Options

Conditions
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Sickle Cell Disease

Intervention / Treatment
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* Drug: Voxelotor


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria Documented diagnosis of sickle cell disease of any genotype confirmed by laboratory testing during screening Ineligible or unable to participate in actively recruiting clinical studies of voxelotor Hemoglobin (Hb) ≤ 10.5 g/dL during screening No alternative treatment options in the judgment of the treating investigator Participants, who if female and of child bearing potential, agree to use highly effective methods of contraception from study start to 30 days after the last dose of voxelotor, and who if male, agree to use barrier methods of contraception from study start to 30 days after the last dose of voxelotor Patient has provided documented informed consent (the informed consent form [ICF] must be reviewed and signed by each participant),or for participants under 18 years of age, signed parental/legal guardian consent and participant assent. Exclusion Criteria Female who is breast feeding or pregnant Hepatic dysfunction characterized by alanine aminotransferase (ALT) >4 × ULN Patients with clinically significant bacterial, fungal, parasitic, or viral infection which require therapy: Patients with acute bacterial infection requiring antibiotic use should delay screening/enrollment until the course of antibiotic therapy has been completed. Patients with known active hepatitis A, B, or C or who are known to be human immunodeficiency virus (HIV) positive Renal dialysis Non-SCD conditions or complications of SCD for which survival beyond 3 months is unlikely, in the opinion of the treating Investigator Any condition affecting drug absorption, such as major surgery involving the stomach or small intestine (prior cholecystectomy is acceptable) Participated in another clinical trial of an investigational agent (or medical device) within 30 days or 5 half-lives of date of informed consent, whichever is longer, or is currently participating in another trial of an investigational agent (or medical device) Medical, psychological, or behavioral conditions, which, in the opinion of the Investigator, may preclude safe participation, interfere with compliance or preclude informed consent The Sponsor Medical Monitor makes the sole and final enrollment determination for any patient.

Ages Eligible for Study
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Minimum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Voxelotor|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |