Oral Contraceptive and Strength Training

Study Overview
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Brief Summary
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Cross sectional study investigating the effect of strength training in users and non-users of oral contraceptives (OC) (2nd generation OC)

Official Title
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E5 - Oral Contraceptive and Strength Training (2nd Generation)

Conditions
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Healthy

Intervention / Treatment
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* Other: no oral contraceptive and training
* Other: oral contraceptive and training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18.5 - 30 years BMI < 30 Exclusion Criteria: Medicine influencing protein turnover Surgery on the knee Arthritis Diabetes Smoking irregular menstruation (<24 days or >35 days cycles) Non-users: not have used contraceptives for the last 3 months. Unstable weight (+/- 5 kg within the last 6 months) Regular training/exercise more than 2 hours/week for the last 6 months. Maximum 70 km of cycling transport/week. Strength training >1time/month for the last 6 months. Pregnancy Diet og eating disorder Can not read or understand danish

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Cross sectional study with 16 in each group.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: oral contraceptive and training<br>Users of oral contraceptive training for 10 weeks | Other: oral contraceptive and training<br>* 10 weeks of training in a group of users of oral contraceptives<br>|
| Placebo Comparator: no oral contraceptive and training<br>Non-users of oral contraceptive training for 10 weeks | Other: no oral contraceptive and training<br>* 10 weeks of training in a group of oral contraceptive users<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle mass | Change in muscle mass determined by MRI scan of thigh muscle | Baseline + after 10 weeks of resistance training. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle fiber size | Change in muscle fiber cross sectional area measured by histology. | Baseline + after 10 weeks of resistance training. | 
| Muscle strength | Change in isometric strength | Baseline + after 10 weeks of resistance training. | 
| Blood values | Change in sex hormone profile measured by blood sample analysis | Baseline + after 10 weeks of resistance training. | 
| Functionality | Change in jump performance by RSI (Reactive strength index) measures | Baseline + after 10 weeks of resistance training. | 
| Fat free mass (FFM) | Change in FFM measured by dual energy x-ray absorptiometry (DXA) scan of whole body composition | Baseline + after 10 weeks of resistance training. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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exercise, oral contraceptive, strength training