Characteristics and Prognosis of Moderate or Severe Tricuspid Regurgitation

Study Overview
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Brief Summary
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The tricuspid valve : its evaluation is relatively difficult in echocardiography and the management of tricuspid valve diseases remains poorly codified.

Detailed Description
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The tricuspid valve is often called the forgotten valve because its evaluation is relatively difficult in echocardiography and the management of tricuspid valve diseases remains poorly codified. In developed countries, TR is mainly functional, related to a remodeling of the right cavities in response to an increase in the load conditions. This remodeling induces a dilation of the tricuspid ring and / or a tenting of the tricuspid leaflets. Once TR is present, a vicious circle settles because TR increases right ventricle dilation. Transthoracic echocardiography is the key examination allowing noninvasive, quantification and assessment of hemodynamic repercussions of TR. TR remains asymptomatic for a long time, often diagnosed with a significant delay at the stage of advanced right heart failure. At this stage, the surgical risk is important, at least more important than for left heart valve diseases and it is therefore essential to define the right time for proposing valvular surgery to patients. Indeed, TR is an independent factor of mortality and only surgical treatment improves the prognosis. Current guidelines remain vague given the low number of prognostic studies and of their contradictory results often influenced by the significant comorbidities of patients, the presence of pulmonary hypertension or left heart valve disease. Only a minority of patients (<1%) is referred to surgery because operative mortality is often judged unacceptable in elderly patients or in cases of advanced right ventricular dysfunction. The constitution of a prospective and retrospective cohort will improve the state of knowledge on etiologies, natural history, prognosis and management of patients with moderate or severe TR.

Official Title
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Clinical and Echocardiographic Characteristics and Prognosis of trIcuspid regurgiTation (EPIT): Prospective and Retrospective Follow-up of a Cohort of Patients With Moderate or Severe Tricuspid Regurgitation

Conditions
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Tricuspid Valve Disease

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age >18 ans inclusion criteria: moderate or severe tricuspid regurgitation exclusion criteria: Refusal to participate/ prior surgery of the tricuspid valve

Ages Eligible for Study
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Minimum Age: 18 Months

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall survival | It corresponds to the delay between the diagnostic and the date of death. | 5 Years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Tricuspid regurgitation, tricuspid valve, surgery, outcome, prognosis, mortality, right ventricle, asymptomatic