Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian Disorders

Study Overview
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Brief Summary
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The Cognitive Neuroscience Section of the National Institute of Neurological Disorders and Stroke proposes to continue its cross-sectional and longitudinal studies of cerebral metabolism in frontal lobe dementias and atypical basal ganglia disorders. These studies include repeated assessments of neuropsychological and brain anatomical and metabolic function in subjects with these important and possibly related brain disorders.

Detailed Description
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Objective To continue the cross-sectional and longitudinal studies performed by the Cognitive Neuroscience Section of NINDS on the neuroanatomy, cerebral metabolism, neuropsychology, and genetics of frontotemporal dementia, corticobasal syndrome, and related brain disorders. Study population Frontal lobe dementias and atypical basal ganglia disorders including frontotemporal dementia, corticobasal syndrome, and related brain disorders. Design A cross-sectional assessment of neuropsychological, brain anatomical and metabolic function, and genetic measures in subjects with these disorders. Outcome measures MRI, FDG-PET, neuropsychological and clinical tests, genetics, and neuropathology.

Official Title
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Regional Cerebral Utilization of Glucose in Patients With a Diagnosis of Frontal Lobe Dementia, Atypical Parkinsonian Disorder, and Other Basal Ganglia Disorders

Conditions
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Alzheimer's Disease, Dementia, Down's Syndrome

Participation Criteria
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Eligibility Criteria
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Subjects will be recruited from the NIH referral center, neurological and psychiatric clinics, from self or family referral in response to advertisements or from private physicians. Healthy volunteers will include subjects who are considered at-risk for the development of FTD or CBS and subjects who serve as normal controls matched for key characteristics with the patients. INCLUSION CRITERIA FOR PATIENTS: Diagnosis of possible / probable FTD or CBS Caregiver willing and able to accept the responsibilities involved in the study EXCLUSION CRITERIA: Pregnant women. Women of childbearing potential will be screened by history for the possibility of pregnancy and undergo a urine pregnancy test. These women will be excluded from the imaging portions of the protocol. Behavioral symptoms that would preclude the gathering of data for the study Other medical or social condition that would preclude participation in the opinion of the investigators

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Alzheimer's Disease, Cerebral Metabolism, Cerebrospinal Fluid, Dementia of the Alzheimer Type, 18-F-Fluoro-2-Deoxy-D-Glucose (FDG), Magnetic Resonance Imaging, Positron Emission Tomography, X-Ray Computed Tomography (CT), Senile Dementia, Down Syndrome, Trisomy 21