Cardiopulmonary Exercise Testing as an Outcome Predictor in Coronary Artery Bypass Surgery

Study Overview
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Brief Summary
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This is a prospective cohort study of patients undergoing coronary artery bypass graft surgery. Prior to surgery, participants will undergo submaximal cardiopulmonary exercise testing on a treadmill. Participants will be followed for one month after surgery to assess mortality and non fatal complications.

Detailed Description
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Coronary artery bypass surgery (CABG) is a complex and expensive procedure with great potential for morbidity and mortality. Preoperative evaluation is of paramount importance to optimize results. There is much evidence about the benefits of the cardiopulmonary exercise testing (CPET) in the evaluation of preoperative risk in non-cardiac surgeries. Thus, it is important to evaluate the relationship between parameters obtained in the CPET and the outcomes after cardiac surgery, especially CABG. This is a prospective cohort study in which participants undergo submaximal CEPT on a treadmill prior to CABG. Participants will be followed up for one month after surgery to assess mortality and non fatal complications. It is expected that poor cardiopulmonary fitness is related to worse outcomes in CABG, as already observed in other cardiac pathologies and in non-cardiac surgery.

Official Title
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Cardiopulmonary Exercise Testing as an Outcome Predictor in Coronary Artery Bypass Surgery

Conditions
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Coronary Artery Disease, Surgery--Complications

Intervention / Treatment
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* Diagnostic Test: Cardiopulmonary Exercise Testing


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients undergoing coronary artery bypass grafting surgery at the National Institute of Cardiology, Ministry of Health, Rio de Jnaeiro, Brazil. Exclusion Criteria: Angina CCS IV, heart failure NYHA IV, inability to walk on a treadmill, severe left main coronary artery lesion.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Interventional Model Description: All patients included in the study will perform cardiopulmonary exercise testing prior to surgery
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cardiopulmonary exercise testing<br>All patients included in the study will perform cardiopulmonary exercise testing prior to surgery | Diagnostic Test: Cardiopulmonary Exercise Testing<br>* Cardiopulmonary exercise testing on treadmill prior to coronary artery bypass grafting surgery<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality after cardiac surgery | number of deaths during the first 30 days after cardiac surgery | 30 days |