Development of Automated Analysis to Electroencephelogram (EEG) Data in Patients Treated at the Sagol Hyperbaric Medicine and Research Center at the Years 2017-2019.

Study Overview
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Brief Summary
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DELPhI software developed for the analysis of EEG recordings in response to magnetic stimulation in relation to clinical data.

Detailed Description
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Collection of EEG data, recorded at Sagol center for hyperbaric medicine and research in the years of 2017-2019 of patients arriving to be treated at the hyperbaric chamber before,during and after treatments. EEG was recorded of patients during cognitive tests, resting state and during magnetic stimulation as a part of other array of tests performed at the Sagol center. Anonymous EEG data along with MRI scans, PET-CT, SPECT, cognitive tests, Medical history and medications will be transferred to QuantalX Neuroscience LTD. QuantalX Neuroscience is intending to use the above mentioned data in order to improve DELPhI, an algorithm for the analysis of EEG recordings in response to magnetic stimulation.

Official Title
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Development of Automated Analysis to Electroencephelogram (EEG) Data in Patients Treated at the Sagol Hyperbaric Medicine and Research Center at the Years 2017-2019 - A Retrospective Study

Conditions
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Healthy, CVA, Hemorrhage, TBI (Traumatic Brain Injury), Concussion, Brain, Fibromyalgia, ABD, Adhd, Dementia, Mci, Cognitive Impairment, Cognitive Decline, MS (Multiple Sclerosis)

Intervention / Treatment
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* Other: No intervention, this is a retrospective study.


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects over the age of 18. Subjects that performed at least one EEG test as a part of their hyperbaric treatment at Sagol center Asaf-Harophe. Exclusion Criteria: Subjects with no EEG test or that their EEG recording is in pure quality, not allowing analysis of the data.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| healthy<br> | Other: No intervention, this is a retrospective study.<br>* No intervention, this is a retrospective study.<br>|
| CVA<br> | Other: No intervention, this is a retrospective study.<br>* No intervention, this is a retrospective study.<br>|
| Hammorhage<br> | Other: No intervention, this is a retrospective study.<br>* No intervention, this is a retrospective study.<br>|
| TBI<br> | Other: No intervention, this is a retrospective study.<br>* No intervention, this is a retrospective study.<br>|
| Concussion<br> | Other: No intervention, this is a retrospective study.<br>* No intervention, this is a retrospective study.<br>|
| Fibromyalgia<br> | Other: No intervention, this is a retrospective study.<br>* No intervention, this is a retrospective study.<br>|
| ABD<br> | Other: No intervention, this is a retrospective study.<br>* No intervention, this is a retrospective study.<br>|
| ADHD<br> | Other: No intervention, this is a retrospective study.<br>* No intervention, this is a retrospective study.<br>|
| MCI<br> | Other: No intervention, this is a retrospective study.<br>* No intervention, this is a retrospective study.<br>|
| DEMENTIA<br> | Other: No intervention, this is a retrospective study.<br>* No intervention, this is a retrospective study.<br>|
| COGNITIVE IMPAIRMENT<br> | Other: No intervention, this is a retrospective study.<br>* No intervention, this is a retrospective study.<br>|
| COGNITIVE DECLINE<br> | Other: No intervention, this is a retrospective study.<br>* No intervention, this is a retrospective study.<br>|
| MS<br> | Other: No intervention, this is a retrospective study.<br>* No intervention, this is a retrospective study.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Defining Plasticity (the ratio between excitatory to inhibitory brain response) Means and STD in each cohort. | Measure of the mean and STD Plasticity of each cohort. | through study completion, an average of 1 year | 
| Defining Connectivity (dispersion of brain signal) Means and STD in each cohort. | Measure of the mean and STD Connectivity of each cohort. | through study completion, an average of 1 year | 
| Defining Plasticity (the ratio between excitatory to inhibitory brain response) standard error (SEM) in each cohort. | Measure of the standard error (SEM) of Plasticity of each cohort. | through study completion, an average of 1 year | 
| Defining Connectivity (dispersion of brain signal) standard error (SEM) in each cohort. | Measure of the standard error (SEM) of Connectivity of each cohort. | through study completion, an average of 1 year | 
| Defining Plasticity (excitation/inhibition brain response) coefficient of variation (CV%) in each cohort. | Measure of the coefficient of variation (CV%) of Plasticity of each cohort. | through study completion, an average of 1 year | 
| Defining Connectivity (dispersion of brain signal) coefficient of variation (CV%) in each cohort. | Measure of the coefficient of variation (CV%) of Connectivity of each cohort. | through study completion, an average of 1 year | 
| Defining Plasticity (excitation/inhibition brain response) minimum, median, maximum in each cohort. | Measure of the minimum, median, maximum of Plasticity of each cohort. | through study completion, an average of 1 year | 
| Defining Connectivity (dispersion of brain signal) minimum, median, maximum in each cohort. | Measure of the minimum, median, maximum of Connectivity of each cohort. | through study completion, an average of 1 year | 
| Defining Plasticity (excitation/inhibition brain response) 95% confidence interval in each cohort. | Measure of the 95% confidence interval of Plasticity of each cohort. | through study completion, an average of 1 year | 
| Defining Connectivity (dispersion of brain signal) 95% confidence interval in each cohort. | Measure of the 95% confidence interval of Connectivity of each cohort. | through study completion, an average of 1 year |