Study on the Difference of Preoperative Related Parameters in Children With or Without Microcornea Within Less Than One Year Old

Study Overview
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Brief Summary
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This subject is mainly to study difference of Congenital cataract preoperative related parameters in children with or without Microcornea within Less than one year old. A total of 186 eyes of 117 people were collected with relevant ocular biological parameters, including age, horizontal diameter of the cornea, Eye axis, intraocular pressure, steep axis of corneal curvature, flat axis of corneal curvature, corneal thickness, lens thickness, anterior chamber depth. At present, because the definition of patients with small cornea is not clear enough, the study subjects are divided into 4 groups according to the horizontal corneal diameter of 9.0mm, 9.5mm, and 10.0mm, namely ≤9.0mm group, 9 9.5mm group, 9.5 10.0mm group and The >10.0mm group compares the differences between each other, and tries to provide a reference for the diagnosis of children with small cornea at a young age.

Official Title
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Study on the Difference of Preoperative Related Parameters in Children With or Without Microcornea Within Less Than One Year Old

Conditions
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Microcornea Within One Year of Age

Intervention / Treatment
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* Device: Collect ocular biological parameters including age, corneal diameter, eye axis, intraocular pressure, steep&flat axis of corneal curvature, corneal thickness, lens thickness, anterior chamber depth


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Congenital cataract children with or without Microcornea within Less than one year old Complete collection of eye biological parameters before the first-stage Congenital cataract surgery The nutritional status and development of the included subjects have no obvious defects Exclusion Criteria: congenital persistent pupilary membrane lens sublaxation or lens dislocotion Marfan syndrome Down's Syndrome Peters abnormality Fevr history of obvious eye trauma obvious macula long-term (local or systemic) use of glucocorticoids.

Ages Eligible for Study
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Minimum Age: 1 Month
Maximum Age: 12 Months

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Corneal horizontal diameter ≤9.00mm group<br> | Device: Collect ocular biological parameters including age, corneal diameter, eye axis, intraocular pressure, steep&flat axis of corneal curvature, corneal thickness, lens thickness, anterior chamber depth<br>* observation<br>|
| Corneal horizontal diameter 9.00mm 9.50mm group<br> | Device: Collect ocular biological parameters including age, corneal diameter, eye axis, intraocular pressure, steep&flat axis of corneal curvature, corneal thickness, lens thickness, anterior chamber depth<br>* observation<br>|
| Corneal horizontal diameter 9.50mm 10.00mm group<br> | Device: Collect ocular biological parameters including age, corneal diameter, eye axis, intraocular pressure, steep&flat axis of corneal curvature, corneal thickness, lens thickness, anterior chamber depth<br>* observation<br>|
| Corneal horizontal diameter >10.00mm group<br> | Device: Collect ocular biological parameters including age, corneal diameter, eye axis, intraocular pressure, steep&flat axis of corneal curvature, corneal thickness, lens thickness, anterior chamber depth<br>* observation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| horizontal diameter of the cornea | Use a ruler to measure during surgery | 2015.5.1-2020.12.1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| age |  | 2015.5.1-2020.12.1 | 
| Eye axis | A-type ultrasonic measuring instrument | 2015.5.1-2020.12.1 | 
| intraocular pressure | i care handheld tonometer | 2015.5.1-2020.12.1 | 
| steep axis of corneal curvature | Handheld eye curvature measuring instrument | 2015.5.1-2020.12.1 | 
| flat axis of corneal curvature | Handheld eye curvature measuring instrument | 2015.5.1-2020.12.1 | 
| corneal thickness | Handheld corneal thickness measuring instrument | 2015.5.1-2020.12.1 | 
| lens thickness | A-type ultrasonic measuring instrument | 2015.5.1-2020.12.1 | 
| anterior chamber depth | SS-OCT | 2015.5.1-2020.12.1 |