Clinical, Immunological, Genomic, Virological and Bioethical Actors of COVID-19

Study Overview
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Brief Summary
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The STOP-Coronavirus project is an integrated and multidisciplinary study that aims to analyze the impact that various factors have on the evolution and prognosis of the current COVID-19. Clinical presentation, immunological markers, therapeutic strategies, host and virus genomics, and bioethical considerations will be analyzed with a prospective multicenter cohort of patients with a diagnosis of COVID-19.

Detailed Description
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This project led my Dr Aguado Garcia, has established 8 Work Parckages (WP) to analyze factors involved in the impact of COVID-19. WP that correspond to University Hospital Fundacion Jimenez Diaz are described in this register across different objectives: WP 3 (Dr Ayuso García) is aimed to analyze the genetic markers of host susceptibility associated with clinical evolution of COVID-19. WP 6 (Dr Ruiz Hornillos) will study the socio-economic and bioethical repercussions of COVID-19. WP 7 (Dr Perales) will analyze the complexity of the spectrum of SARS-CoV-2 mutants and their possible association with the evolutionary course of COVID-19 This project will guide and individualize the clinical and therapeutic approach to COVID-19 and mitigate the health and social impact of the pandemic.

Official Title
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STOP-Coronavirus: Clinical, Immunological, Genomic, Virological and Bioethical Actors of COVID-19

Conditions
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Covid19

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Confirmed diagnosis of COVID-19 (positive RT-PCR for SARS-CoV-2 in respiratory sample). Exclusion Criteria: Suspected coronavirus infection without diagnostic confirmation

Ages Eligible for Study
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Minimum Age: 18 Months

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Identification of host genetic markers associated with the evolution of COVID-19 | Based on the cohort of patients with a confirmed diagnosis of COVID-19 and according to severity categories, a Genome-wide association study (GWAS) will be carried out | 4 months | 
| Analysis of bioethical aspects related to in-hospital management of the health crisis | Through structured interviews, data collection in each epidemiological period, and evaluation of the application of recommended measures from the bioethical point of view, a comparative study will be carried out between hospitals, taking into account the use of resources and analyzing the situations of ethical commitment for healthcare professionals, patients and institutions | 10 months | 
| Analysis of the spectrum of mutants of SARS-CoV-2 and its possible association with the clinical evolution of COVID-19 | From the mass sequencing of SARS-CoV-2 and the calculation of viral variability indices, it will be studied whether or not there is an association between the spectrum of viral mutants and clinical evolution | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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genomics, bioethics, SARS-CoV-2