The Effect of Frailty on Balance, Activities of Daily, and Exercise Capacity in COPD

Study Overview
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Brief Summary
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The investigators aim to demonstrate whether balance, cognition and activities of daily living have changed in COPD patients with and without frailty.

Detailed Description
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COPD is a common, preventable and treatable disease characterized by progressive respiratory symptoms and airflow limitation. Frailty defines a clinical syndrome characterized by multiple system effects, leading to decreased functional reserve and increased sensitivity to dependence or mortality following minor stress events. Inflammation, lack of physical activity, reduced exercise efficiency and maximum oxygen uptake may contribute to the development of frailty in patients with COPD. Balance, cognition and activities of daily living are associated with COPD. This study will evaluate the effect of frailty on balance, cognition and activities of daily living in patients with COPD.

Official Title
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The Effect Of Frailty Level On Balance, Cognition And Activities Of Daily Living In COPD

Conditions
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COPD, Frailty

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: COPD patients who have been clinically stable for the last four weeks and who have not undergone drug change for the last four weeks Being 55 years of age or older Accepted to participate in the study (Able and wililing to complete the informed consent process) Co-operate Patients with COPD who are ambulant without support or an assistive device Exclusion Criteria: Neurological, cardiac or orthopedic diseases Other chronic diseases that may affect balance and walking

Ages Eligible for Study
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Minimum Age: 55 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Frail patients with COPD<br>No intervention | |
| Non-frail patients with COPD<br>No intervention | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Presence of The Frailty Will Be evaluated Using The Frailty Criteria by Fried | Frailty will be identified by the presence of three or more of the following criteria unintentional weight loss (10 Ibs in past year), weakness (grip strength), self-reported exhaustion, slow walking speed and low physical activity. Patients with three or more of the criteria present were classified as frail. | 1st Day | 
| Balance Assessment Using Functional Reach Test | The Functional Reach Test measures how far patient can reach forward from a normal relaxed stance. | 1st Day | 
| Cognition Using MoCA-Test | Cognitive function will be evaluated with the secreening tool the Montreal Cognitive Assessment (MoCA). The MoCA is a 30-point screening tool. | 1st Day | 
| Perform activities of daily living (ADL) will be evaluated using the Glittre ADL-test | Glittre ADL-test was designed specifically to assess the functional limitation in patients with COPD. Glittre ADL-test time will be considered the main outcome variable, and will be recorded in minutes (metric). | 1st Day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Exercise Capacity Using 6-Minute Walk Test | The standard protocol of the test is applied in a 30-meter continuous corridor. Standard instructions are given during testing. | 1st Day | 
| Disease-Related Quality of Life Assessment | COPD evaluation test (CAT) was developed to help assess health status. | 1st Day | 
| Respiratory Muscle Strength Assessment | Respiratory muscle strength will be evaluated by non-invasive methods by measuring maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP). | 1st Day | 
| Shortness of Breath Assessment | Modified Medical Research Council (mMRC) dyspnea scale will be used to determine the shortness of breath severity. | 1st Day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COPD, Frailty, Balance, Cognition, Activities of Daily Living