Effectiveness of Different Candies Against Bad Breath

Study Overview
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Brief Summary
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This study is to analyze whether the candies can relieve or eliminate bad breath, both subjectively and objectively.

Detailed Description
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This study is to systematically examine an existing candy, which is easily available and is intended to relieve or eliminate bad breath. The main aim of the study is to determine the effectiveness of the candies on the subjective perception of bad breath. The secondary outcome of the study is to investigate whether there is actually a decrease in volatile sulphur compounds (VSC) in the exhaled air and also a decrease in bad breath during organoleptic measurement. The purpose of the study is to investigate whether the different candies can relieve or eliminate bad breath, both subjectively and objectively.

Official Title
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Effectiveness of Different Candies Against Bad Breath

Conditions
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Bad Breath

Intervention / Treatment
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* Other: Intake of 3 different candies against bad breath


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Non- smoker No general medical illness or medication Exclusion Criteria: Allergies/intolerances to ingredients of the products used Chronic diseases Smoker Pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Interventional Model Description: Three different variants of a candy are being tested by each participant. The candies are randomly assigned to the subjects, so that each subject has tested each of the three candies once. Randomization creates a different order for each participant. The study will be carried out on three different days.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: candy intake<br> | Other: Intake of 3 different candies against bad breath<br>* Intake of 3 different candies against bad breath on three different days (2-days interval each) after artificially creating a temporary bad breath (by eating of chips and cheese); analysis of breathing during intake of candy both subjectively and objectively<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Organoleptic analysis of breathing air sample | Assessment of the patient's bad breath on the basis of the subjective assessment of an investigator (scale of 0 to 5 (0, no odor; 1, questionable odor; 2, slight malodor; 3, moderate malodor; 4, strong malodor; 5, severe malodor)) | max 60 minutes at 3 different days | 
| Measurement of volatile sulphur compounds (VSC) in ppb (parts per billion). | Assessment of the patient's bad breath on the basis of the objective assessment by a sulfide monitor (HaliSens® AI Analytical Innovations GmbH, Moosbach, Germany) | max 60 minutes at 3 different days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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halitosis, volatile sulphur compounds