Evaluation of Sleep Apnea and Cardiac Rhythm Abnormalities After Surgery Under General Anesthesia

Study Overview
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Brief Summary
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Higher risk of cardiac and respiratory post-operative events is observed in patients with unrecognised Obstructive Sleep Apnea (OSA). The efficiency of a simple method of OSA screening by analysing ventilation with measurement of nose pressure and nocturnal hypoxemia (oxygen desaturation index) will be assessed. These sleep respiratory analyses will be compared with the research of arrhythmia, in order to show if they are linked to the hypoxemia events. Aggravation of nocturnal respiratory disorder and higher incidence of cardiac and respiratory postoperative complications will be assessed in OSA patients.

Official Title
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Evolution of the Severity of Obstructive Sleep Apnea and Consequences on Cardiac Rhythm Abnormalities After Surgery Under General Anesthesia

Conditions
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Obstructive Sleep Apnea, Arrhythmia

Intervention / Treatment
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* Other: Measure of ODI and heart rhythm


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: orthopaedic, urologic, vascular, digestive surgery under general anaesthesia or sedation age > 45 years old STOP-BANG score>3 Exclusion Criteria: Head and neck surgery, planned prolonged mechanical ventilation after surgery (>24h) Severe COPD Post-operative ICU planned Diagnosed OSA or other sleep disorder breathing

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 99 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Patients suspected to present a Sleep Apnea Syndrom<br>Record nocturnal respiratory and cardiac parameters before and after surgery : Severity of sleep respiratory disorders and relationship with cardiac rhythm abnormalities will be assessed in patients suspected to present Sleep Apnea, before and after surgery under general anesthesia. | Other: Measure of ODI and heart rhythm<br>* Record nocturnal respiratory and cardiac parameters before and after surgery.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in heart rhythm troubles linked to hypoxemia events | Heart rhythm troubles will be assessed 3 times: First time = baseline assessment, during one night before surgery second assessment will occur during the first night after surgery last assessment will take place during the third night after surgery | Before surgery and at first and third night after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in severity of OSA defined by the oxygen saturation index | OSA will be assessed 3 times: First time = baseline assessment, during one night before surgery second assessment will occur during the first night after surgery last assessment will take place during the third night after surgery oxygen saturation index > 10 mandatory for the study oxygen saturation index > 40 : result qualified severe | Before surgery and at first and third night after surgery | 
| Aggravation of cardiac events linked to hypoxemia |  | After surgery from night 1 to night 15 maximum | 
| Change from baseline OSA prevalence and cardiorespiratory complications after surgery |  | Before surgery and at first and third night after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Hypoxia, Perioperative outcomes