Stroke's Gait Pattern Modifications of Induced by Repeated BTI

Study Overview
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Brief Summary
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Chronic stroke patients exhibit gait pattern alterations which are mainly due to spasticity and treated with repetitive multifocal botulinum toxin injection(BTI). Several studies demonstrated that single BTI-session in a single muscle of paretic lower limb(LL) improved kinematic gait parameters(GP) but surprisingly none of them assessed the effects of repetitive multifocal BTI on patient's gait pattern and their duration. The aim was to evaluate the impact of repetitive multifocal BTI-sessions on GP of chronic stroke patients. To that end, gait of patients has been compared using 3D-gait analysis after at least 2 consecutive BTI sessions.

Detailed Description
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All the patients will be tretaed with BTI . these injections will be performed under electrical stimulation control ( 5mA). The dose, the number of site of injection per muscle is at the discretion of the physician according to patients' needs and physicians' routine clinical practice. The dilution the most commonly used will depend on the type of BoNT-A (BOTOX®, XEOMIN® or DYSPORT®) and was 100 U for 2.5ml (BOTOX® and XEOMIN®) or 500 U for 2.5 ml (Dysport®).

Official Title
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Improvement of Chronic Stroke Patients Gait Pattern Following Repetitive Multifocal Botulinum Toxin Injection Sessions in Paretic Lower Limb: an Observational Study.

Conditions
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Effect of Repeated Botulinum Toxin Injection on Gait Pattern in Stroke Patients

Intervention / Treatment
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* Other: Motion analysis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ->18 years a single hemispheric cerebral vascular lesion more than 6 months previously able to walk 10 meters without any assistance having benefited of at least 2 consecutive BTI sessions, second 3D gait analysis performed at least 3 months after the last BTI. Exclusion Criteria: patient's refusal to participate to the study Inability to read the selected text Inability to cooperate No affiliation to social security

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Chronic spastic stroke patients<br>Chronic spastic stroke patients treated regularly with botulinum toxin injection in lower limb muscles | Other: Motion analysis<br>* Motion analysis was used to assess the modifications of gait pattern in chronic spastic stroke patients regularly treated with botulinum toxin injection<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| kinematics gait parameters | peak knee flexion in swing phase(°) | 3h | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| spatiotemporal gait parmeters | gait velocity(m/s) | 3h | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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botulinum toxin injection, stroke, 3D motion analysis, gait pattern