commd7 Gene Expression in ALL

Study Overview
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Brief Summary
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study the expression pattern of COMMD7 gene in acute lymphoblastic leukemia. investigate correlation between the expression level of COMMD7 gene with other diagnostic parameters and prognosis in ALL .

Detailed Description
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Acute lymphoblastic leukemia (ALL) is a neoplastic disorder of lymphoid progenitor cells characterized by diverse cytogenetic and molecular abnormalities with peaks of prevalence for 2-5-year-old patients and those older than 50. Treatment strategies using risk-adapted chemotherapy cure more than 80% of childhood cases, but around 20 to 30% relapse developing serious complications including death.( 1) In the past decade, the available treatments for patients with acute lymphoblastic leukemia (ALL) have rapidly expanded, in parallel with an increased understanding of the genomic features that impact the disease biology and clinical outcomes.(2) The copper metabolism MURR1 domain (COMMD) protein family involved in tumor development and progression in several types of human cancer, but little is known about the function of COMMD proteins in hematological malignancy. (3) COMMD7, a member of the COMMD, which is located on chromosome 20q11.21, has been reported associated with tumor progression in human solid cancers [4]. COMMD7 is overexpressed in pancreatic ductal adenocarcinoma (PDAC) cells, associated with poor prognosis. [5]. Another study revealed that COMMD7-overexpressed hepatocellular carcinoma (HCC) cells promoted the proliferation of naïve HCC cells (6) A recent study was found that high expression of COMMD7 is a potential biomarker for adverse outcomes and poor prognosis in AML. (7) . However, to date, the expression of COMMD7 in acute lymphoblastic leukemia and its prognostic value remain unclear.

Official Title
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The Copper Metabolism MURR1 Domain 7 (COMMD7) Gene Expression in Acute Lymphoblastic Leukemia

Conditions
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ALL

Intervention / Treatment
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* Diagnostic Test: Reverse transcription-quantitative polymerase chain reaction (RT-qPCR).


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients newly diagnosed with acute lymphoblastic leukemia , male or female at any age. Exclusion Criteria: history of anti-neoplastic therapy, such as chemotherapy or radiotherapy. Any other types of cancers. Any clinically systemic acute or chronic inflammatory disease/s within one months.
Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| PATEINTS<br>51 patients newly diagnosed with acute lymphoblastic leukemia | Diagnostic Test: Reverse transcription-quantitative polymerase chain reaction (RT-qPCR).<br>* Reverse transcription-quantitative polymerase chain reaction on bone marrow aspirates to detect The expression pattern of COMMD7 gene in acute lymphoblastic leukemia<br>|
| controls<br>51 normal persons | Diagnostic Test: Reverse transcription-quantitative polymerase chain reaction (RT-qPCR).<br>* Reverse transcription-quantitative polymerase chain reaction on bone marrow aspirates to detect The expression pattern of COMMD7 gene in acute lymphoblastic leukemia<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The expression pattern of COMMD7 gene in acute lymphoblastic leukemia | Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) TO DETECT EXPRESSION pattern in ALL | BASELINE | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between the expression level of COMMD7 GENE with other diagnostic parameters and prognosis in ALL |  | baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COMMD7 , ALL