Associations of Exposure to Bisphenol A With Blood Pressure and Epigenetic Change

Study Overview
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Brief Summary
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Bisphenol A(BPA) is an endocrine disrupting chemical, which mimics the action of estrogen. Previous studies reported that BPA exposure is associated with increased risk of cardiovascular diseases. Exposure to BPA occur mainly through oral route, and epoxy coating of canned food is one of the well established source. The investigators hypothesis is that increased BPA exposure from canned beverage would disrupt normal physiology in a short term. In the present trial the investigators are to investigate whether increased BPA exposure by consuming canned beverage actually affect cardiovascular indices and epigenetic feature. For this aim, the investigators will conduct a cross-over trial.

Official Title
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Associations of Exposure to Bisphenol A With Blood Pressure and Epigenetic Change

Conditions
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Hypertension

Intervention / Treatment
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* Other: Can 1
* Other: Can 2
* Other: Glass


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Reside in Seoul Who provided Informed consent Exclusion Criteria: Who has cancer Who has disease or disorder of liver, nervous system, endocrine system, cardiovascular system Who does not provieded informed consent

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Glass<br>consume beverage in glass first and cross over to other interventions | Other: Can 1<br>* drink the beverage in a can and a glass bottle<br>Other: Can 2<br>* Consume two canned beverage<br>Other: Glass<br>* consume two glass bottled beverage<br>|
| Experimental: Can 1<br>consume one canned beverage and a glass bottled beverage first and cross over to other interventions | Other: Can 1<br>* drink the beverage in a can and a glass bottle<br>Other: Can 2<br>* Consume two canned beverage<br>Other: Glass<br>* consume two glass bottled beverage<br>|
| Experimental: Can 2<br>Consume two canned beverage first and cross over to other interventions | Other: Can 1<br>* drink the beverage in a can and a glass bottle<br>Other: Can 2<br>* Consume two canned beverage<br>Other: Glass<br>* consume two glass bottled beverage<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood Pressure |  | 2 hours after consuming beverage | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percent DNA methylation |  | 2 hours after consuming the beverage | 
| Heart Rate Variablility |  | 2 hours after consuming the beverage |