Iron Metabolism in Dragon Boat Athletes

Study Overview
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Brief Summary
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The purpose of the study is: To investigate the effect of sport-specific stress in the iron metabolism of dragon boat athletes To investigate the effects of sport-specific stress in the activity of pro-hepcidin and hepcidin

Detailed Description
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This investigation evaluates the effects of sport-specific stress in iron metabolism of dragon boat athletes. Recent studies showed a significant increase in hepcidin activity under exercise (Röcker L. et al.(2005): Iron regulatory protein hepcidin is increased in female athletes after a marathon. European Journal of Applied Physiology, S. 95, 569-571)which possibly influences the iron metabolism. In particular in this investigation the activity of pro-hepcidin and hepcidin under sport-specific stress is analysed. Therefore elite dragonboat athletes will be included to this study. Every athlete is tested once. At one exercise day from every athlete the iron metabolism especially the change of hepcidin, prohepcidin and iron before and after a specific dragonboat intervention is analysed.

Official Title
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Iron Metabolism in Dragon Boat Athletes - An Analysis of Changes in Blood Count Parameters Under Sport-specific Stress

Conditions
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Anaemia

Intervention / Treatment
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* Other: specific dragon boating training intervention
* Other: specific dragon boat intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: athletes performing dragon boat sport Exclusion Criteria: acute clinically significant intercurrent diseases
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: sports intervention male<br>male athletes of the german national dragon boat team | Other: specific dragon boating training intervention<br>* male athletes of the german national dragon boat team performing three specific training units at one day<br>|
| Active Comparator: sports intervention women<br>women athletes of the german national dragon boat team | Other: specific dragon boat intervention<br>* women athletes of the german national dragon boat team performing two specific training units and one weight lifting test at one day<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change from Baseline in prohepcidin after performing dragonboating | one meassurement of prohepcidin immediate before and within three hours after performing two to four specific dragonboat interventions at the same day | pre and post exercise intervention at the same day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| haematocrit | one meassurement of haematocrit immediate before and within three hours after performing two to four specific dragonboat intervention at the same day | pre and post exercise intervention at the same day | 
| value of reticulocytes | one meassurement of reticulocytes immediate before performing two to four specific dragonboat interventions | pre exercise | 
| value of hypochromic erythrocytes | one meassurement of hypochromic erythrocytes immediate before performing two to four specific dragonboat interventions | pre exercise | 
| change from Baseline in serum iron after performing dragonboating | one meassurement of serum iron immediate before and within three hours after performing two to four specific dragonboat interventions at the same day | pre and post exercise intervention at the same day | 
| value of transferrin | one meassurement of transferrin immediate before performing two to four specific dragonboat interventions | pre exercise | 
| value of transferrin saturation | one meassurement of transferrin saturation immediate before performing two to four specific dragonboat interventions | pre exercise | 
| value of ferritin | one meassurement of ferritin immediate before performing two to four specific dragonboat interventions | pre exercise | 
| change from Baseline in hepcidin after performing dragonboating | one meassurement of hepcidin immediate before and within three hours after performing two to four specific dragonboat interventions at the same day | pre and post exercise intervention at the same day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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iron metabolism, hepcidin, dragon boating, sport-specific stress, iron, anaemia, sport