Virtual Reality for Neglect Diagnostics

Study Overview
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Brief Summary
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Compared to the classical paper and pencil-tests, testing patients in our virtual reality setup might have a higher sensitivity and specificity.

Official Title
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Virtual Reality for Neglect Diagnostics

Conditions
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Spatial Neglect, Stroke

Intervention / Treatment
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* Behavioral: virtual reality setup
* Behavioral: paper and pencil tests
* Other: c-mri


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria for neglect patients: age ≥18 and <80 years first stroke neglect symptoms no hemianopsia symptoms consent given by the patient Inclusion Criteria for hemianopsia patients: age ≥18 and <80 years first stroke no neglect symptoms hemianopsia symptoms consent given by the patient Inclusion Criteria for Controls: age ≥18 and <80 years no neurological deficits informed consent Exclusion Criteria (for all groups): language comprehension deficits motor deficits of the upper extremities cognitive impairments (MMSE <20 or SKT >15 or DEMTEC >12) depression seizure disorders claustrophobia

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with Neglect<br> | Behavioral: virtual reality setup<br>* testing for neglect in a virtual reality setup<br>Behavioral: paper and pencil tests<br>* testing for neglect with the classical paper-and-pencil tests<br>Other: c-mri<br>* structural and functional (resting state) imaging<br>|
| Patients with Hemianopsia<br> | Behavioral: virtual reality setup<br>* testing for neglect in a virtual reality setup<br>Behavioral: paper and pencil tests<br>* testing for neglect with the classical paper-and-pencil tests<br>Other: c-mri<br>* structural and functional (resting state) imaging<br>|
| Healthy age-matched controls<br> | Behavioral: virtual reality setup<br>* testing for neglect in a virtual reality setup<br>Behavioral: paper and pencil tests<br>* testing for neglect with the classical paper-and-pencil tests<br>Other: c-mri<br>* structural and functional (resting state) imaging<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Feasibility | Feasibility of the use of a virtual reality setup in the diagnostics of neglect | within the first 2 years after stroke | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sensitivity and Specificity | The diagnostics of neglect via a virtual reality setup is more sensitive and more specific than the standard diagnostics via paper-and-pencil Tests | within the first 2 years after stroke | 
| mri (functional (resting state) and structural imaging | We hypothesize that there are connectivity-based differences in the different stages of neglect and anatomical and functional connectivity correlates with respect to behavioural impairment. | within the first 2 years after stroke | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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stroke, neglect, hemianopsia, virtual reality