Application of Intrahepatic Arterial Infusion Chemotherapy for Patients With High Risk of Liver Metastases After Pancreatic Cancer Surgery

Study Overview
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Brief Summary
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Clinical results on intra-arterial adjuvant chemotherapy for prevention of liver metastasis following curative resection of pancreatic cancer

Detailed Description
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In this study, the investigator try to select 80 patients who received radical surgery for pancreatic cancer, whose circulating tumor cells(CTCs) count then performed on intraoperative portal venous blood to predict postoperative liver metastasis and were divided into two groups. for those who have high CTCs count may have more chance for the occurrence of postoperative liver metastasis was applied hepatic arterial perfusion chemotherapy with minimal dynamic randomization. The aim is to evaluate the feasibility of hepatic arterial infusion chemotherapy for the prevention of postoperative liver metastasis and improvement of prognosis of pancreatic cancer, so as to further improve postoperative management of pancreatic cancer

Official Title
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Application of Intrahepatic Arterial Infusion Chemotherapy for Patients With High Risk of Liver Metastases After Pancreatic Cancer Surgery

Conditions
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Pancreatic Ductal Adenocarcinoma, Who Have High CTCs Count in Portal Venous Blood, Liver Metastases

Intervention / Treatment
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* Device: Intrahepatic Arterial Infusion


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: pancreatic cancer patients who received the radical operation Exclusion Criteria: who accepted chemotherapy before operation or who cannot or do not will to accepted enrolled into this study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Pancreatic cancer patients who received hepatic arterial perfusion chemotherapy after operation
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intrahepatic Arterial Infusion chemotherapy<br>chemotherapy through intrahepatic arterial Infusion is one of the most widely used liver tumor treatments. | Device: Intrahepatic Arterial Infusion<br>* Intrahepatic Arterial Infusion chemotherapy is one of the most widely used liver tumor treatments.<br>|
| No Intervention: control<br>chemotherapy through Peripheral venous is one of the regularly used method. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Death | Overall survival time after operation | up to 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pancreatic ductal adenocarcinoma, arterial infusion chemotherapy, liver metastases