linjc16/ctgov huggingface dataset:
Accuracy Of Skin Prick Test Using In-house Wheat Extract For The Diagnosis Of IgE-mediated Wheat Allergy: A Pilot Study

Study Overview
=================
Brief Summary
-----------------
Nowadays, commercial wheat extract is widely accessible, and is used for skin prick test for wheat allergy. However, commercial wheat extracted for skin prick test have less precise test result compared to extract from omega-5 gliadin, which is one of the major allergen with immediate wheat allergy.

Official Title
-----------------
Accuracy Of Skin Prick Test Using In-house Wheat Extract For The Diagnosis Of IgE-mediated Wheat Allergy: A Pilot Study

Conditions
-----------------
Wheat Allergy

Intervention / Treatment
-----------------
* Other: Commercial extract and in-house wheat extract


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: A patient with the age of 1-15 year old A history of symptoms that suspected of type 1 hypersensitivity (eg. Urticaria, angioedema, wheezing, anaphylaxis) occur within 4 hours after wheat ingestion. Patients attend in allergy clinic, pediatric department, Siriraj hospital since 2007-2012 Exclusion Criteria: First sign and symptom happens more than 4 hours since wheat ingestion Have underlying disease such as heart disease, epilepsy etc. Have contraindication for performed skin prick test

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 15 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Food challenge, skin test<br>Skin test by two extract commercial, and in-house extract. and open challenge with wheat (except in patient with history of wheat anaphylaxis: assume as challenge positive) | Other: Commercial extract and in-house wheat extract<br>* Patients with a history of wheat allergy underwent two skin test extracts, and open challenge with wheat. A blood test for specific IgE was performed in the same time.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| correlation skin test result and food challenge result |  | 3 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| comparison of skin test result and specific IgE to challenge result |  | 3 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
skin test, open wheat challenge
Regression of Hamstring Flexibility and Performance in Children With Duchenne Muscular Dystrophy

Study Overview
=================
Brief Summary
-----------------
Investigator investigated that regression of hamstring flexibility and performance in children with Duchenne Muscular Dystrophy.

Detailed Description
-----------------
Flexibility of hamstrings was evaluated by Popliteal Angle test. Performance was evaluated 6 Minute Walk Test (6 MWT). Regression of hamstring flexibility and performance was examined regression tests. Correlation was examined between popliteal angle test and parameter of North Star Ambulation Assessment.

Official Title
-----------------
Regression of Hamstring Flexibility and Performance in Children With Duchenne Muscular Dystrophy

Conditions
-----------------
Duchenne Muscular Dystrophy, Performance, Flexibility

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: To be a Duchenne Muscular Dystrophy diagnosis, Being in the ambulatory period and climbing four steps independently, to be Level 1 and Level 2 according to Brooke Lower Functional Classification Test To be able to cooperate No any severe contracture in the lower limbs which may prevent assessments, Exclusion Criteria: Children who fail to meet these criteria study.

Ages Eligible for Study
-----------------
Minimum Age: 5 Years
Maximum Age: 14 Years

Sexes Eligible for Study
-----------------
Male

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Popliteal Angle Test | The Popliteal Angle Test was used to assess hamstring flexibility. Child asked to rise lower leg straight. Incomplete angle degree of full extension is popliteal angle. | 5 minute | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 6 Minute Walk Test | 6 Minute Walk Test was used to assess performance with children Duchenne MUscular Dystropy. | 6 minute | 
| North Star Ambulation Assessment | The North Star Ambulatory Assessment (NSAA) is used to assess mobility for in ambulatory children with DMD for 5 years. NSAA is consist of 17 items from stand to run. | 20 minute | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Duchenne Muscular Dystrophy, performance, hamstring flexibility, regression
Excision Size and Location on the Postoperative Pain After Nevi Excision in Children

Study Overview
=================
Brief Summary
-----------------
The primary purpose of this study is to investigate the effects of excised surface area/body surface area ratio and location of excision on the postoperative pain after nevi excision in children. The primary purpose of this study is to investigate the effects of excised surface area/body surface area ratio and location of excision on the emergence excitation after nevi excision in children.

Official Title
-----------------
Effect of Excised Surface Area/Body Surface Area Ratio and Location of Excision on the Postoperative Pain After Nevi Excision in Children: Observational Study

Conditions
-----------------
Anesthesia, Endotracheal

Intervention / Treatment
-----------------
* Procedure: nevi excision


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: children undergoing nevi excision on general anesthesia Exclusion Criteria: development disorder neurological disorder psychological disorder

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 7 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: nevi excision|After general anesthesia, nevi excision in children is performed.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative pain score | postoperative pain score after nevi excision | up to 3 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| emergence agitation score | emergence agitation score after nevi excision | up to 3 hours |
Procalcitonin Level and Kinetics in Children With Bacterial Infections

Study Overview
=================
Brief Summary
-----------------
The purposes of this study are: To determine whether procalcitonin level at admission of pediatric patients with bacterial infections can be used as a marker for prediction of defervescence and hospitalization length To examine the kinetics of procalcitonin in pediatric patients with bacterial infections and persistent fever

Official Title
-----------------
Procalcitonin Level as a Prognostic Marker and Its' Kinetics in Children With Bacterial Infections

Conditions
-----------------
Bacterial Infections, Bacteremia, Meningitis, Urinary Tract Infection, Mastoiditis, Lobar Pneumonia, Septic Arthritis, Cellulitis, Osteomyelitis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Positive blood, urine, synovial, bone, pleural effusion, abscess or CSF culture Cellulitis, lobar pneumonia, osteomyelitis,

Ages Eligible for Study
-----------------
Minimum Age: 3 Days
Maximum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| a<br>children with proven of probable invasive bacterial infections | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| time to defervescence |  | discharge | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| length of hospitalization |  | discharge | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
UTI
Value of Sonographic Diagnosis of Toddler's Fracture of the Tibia

Study Overview
=================
Brief Summary
-----------------
This fracture of the distal tibia occurs in 1 to 4 year-old-children. Timely diagnosis is important, because it obviates the need for investigations to archive adequate treatment as well as to prevent unnecessary immobilization. The value of sonographic diagnosis of toddler's fracture has been demonstrated. The aim of the present study is to investigate the reliability and accuracy of sonography in the diagnostic workup of the toddler's fracture.

Detailed Description
-----------------
This fracture of the distal tibia occurs in 1 to 4 year-old-children. The child usually presents with an acute onset of limp or refusal to bear weight on one leg. Toddlers and young children may present with guarding, but may not have swelling or noticeable deformity. Radiologic signs can be subtle too. In some cases initial radiographs is negative and fractures are diagnosed on follow-up studies by periosteal reaction. However, timely diagnosis is important, because it obviates the need for investigations to archive adequate treatment as well as to prevent unnecessary immobilization. The value of sonographic diagnosis of toddler's fracture has been demonstrated. In children it is of particular value as it is comfortable and does not involve the use of ionizing radiation. The aim of the present study is to investigate the reliability and accuracy of sonography in the diagnostic workup of the toddler's fracture.

Conditions
-----------------
Pediatric Fractures

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Informed consent Suspicion of Toddlers fractures Exclusion Criteria: 1. Major delay in treatment

Ages Eligible for Study
-----------------
Maximum Age: 5 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Toddlers fractures<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sonographic identification of Toddler's fractures | Comparison of sensitivity and specitivity of sonography and x-ray | 3y | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| US does not cause more discomfort than x-ray |  | 3y | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Sensitivity and Sensitivity
Practical Approaches to Exercise in Moms

Study Overview
=================
Brief Summary
-----------------
This project aims to test the feasibility of a practical physical activity intervention for postpartum women, incorporating the use of body weights worn during typical daily activities.

Detailed Description
-----------------
We are piloting a 3-arm, unblinded, randomized controlled trial in postpartum women; with 10 participants in each study group. Women will be recruited at 2-6 months postpartum, with the intervention lasting through 12 months postpartum. Data collection will include:1) Physical activity; 2) Maternal body composition; 3) Questionnaires to assess:motivation to adopt healthy behaviors, body attitudes, infant feeding practices; 4) Process evaluation to assess: likes and dislikes about the intervention program, suggestions for improving the intervention, reasons for leaving the study. The proposed study time period is 6 months for study recruitment, 18 months to carry out the study, and 6 months for data analysis (total 2 years).

Official Title
-----------------
Practical Approaches to Exercise in Moms

Conditions
-----------------
Body Weight

Intervention / Treatment
-----------------
* Device: Fitbit activity tracker
* Device: Ankle weights


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 2-6 months postpartum women Exclusion Criteria: Premature birth History of serious illness Medically incapable of low-intensity exercise Currently taking medications that cause weight loss

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Group 1<br> | Device: Fitbit activity tracker<br>* Tracks steps taken, floors climbed, and distance traveled. Sleep quality is an additional measurement.<br>|
| Experimental: Group 2<br> | Device: Fitbit activity tracker<br>* Tracks steps taken, floors climbed, and distance traveled. Sleep quality is an additional measurement.<br>Device: Ankle weights<br>* Worn during typical daily activities.<br>|
| No Intervention: Group 3<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in baseline body weight at 12-months postpartum. |  | Baseline and 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
postpartum, physical activity
Study of MR-based IGRT for Prostate Cancer

Study Overview
=================
Brief Summary
-----------------
MR (Magnetic Resonance Imaging) - based IGRT (image-guided radiotherapy) for patients with prostate carcinoma.

Detailed Description
-----------------
Single arm, phase II study, MR (Magnetic Resonance Imaging) - based IGRT (Image-guided radiotherapy) of prostate cancer. Primary endpoint: Grade 2+ GI (gastrointestinal) and genitourinary (GU) toxicity after 2 years.

Official Title
-----------------
Single-arm Phase II Study of MR(Magnetic Resonance Imaging)-Based Image-guided Radiotherapy for Prostate Cancer

Conditions
-----------------
Prostate Cancer

Intervention / Treatment
-----------------
* Radiation: IGRT


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: histologically proven prostate cancer indication for curative treatment ECOG performance scale 0-2 Informed consent Exclusion Criteria: contraindications for curative treatment age<18year previous pelvic radiotherapy or prostatic treatment like TURP (transurethral resection of prostate), HIFU (high intensity focused ultrasound) serious comorbidity leading to inability for IGRT (image-guided radiotherapy) contraindications for MRI (Magnetic Resonance Imaging)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Radiation<br>IGRT 5x 2Gy/week, total dose: 78 Gy | Radiation: IGRT<br>* MR-based IGRT<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| G2+gastrointestinal and genitourinary toxicity at 2 years | Number of participants with G2+-treatment-related genitournary and gastrointestinal adverse events assessed by CTCAE v4.0 and RTOG at 2 years | Total trial treatment duration: 4 years, Duration for individual patient:Study treatment 9 months, Follow-up: 2 years for primary endpoint | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Long-term GU-GI toxicity | Measurement of treatment-related genitournary and gastrointestinal adverse events assessed by CTCAE v4.0 and RTOG at 10 years | 10 years after treatment |
Effect of Nefazodone on Relapse in Females With Cocaine Abuse - 10

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine the effect of nefazodone on relapse to cocaine use in depressed and non-depressed females with cocaine abuse/dependence.

Detailed Description
-----------------
The purpose of this study is to determine the effect of nefazodone on relapse to cocaine in women and if a greater effect will be seen in the dependent condition. A relapse and coping skills questionnaire will be utilized to determine the various factors important to the relapse process.

Official Title
-----------------
Effect of Nefazodone on Relapse in Females With Cocaine Abuse

Conditions
-----------------
Cocaine-Related Disorders

Intervention / Treatment
-----------------
* Drug: Nefazodone


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Female, ages 18-55, cocaine abuse/dependence, use of cocaine 7 days of the last 30 days or of the 30 days prior to current abstinence, less than 90 days current abstinence, at least an 8th grade education. Exclusion Criteria: Unstable medical conditions; current use of Hismanal, Seldane, or Propulsid; dx of MR, OBS, bipolar, schizophrenia.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Nefazodone|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Retention |  |  | 
| Primary drug use |  |  | 
| Depression (secondary) |  |  | 
| Relapse |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cocaine dependence
Incidences of Cuff-related Trauma After Noninvasive Blood Pressure Measurement Between With and Without Padding

Study Overview
=================
Brief Summary
-----------------
Padding with cuff during blood pressure is expected to reduce number of skin crease or petechiae incidence.

Detailed Description
-----------------
Objective Primary Outcome : incidences of skin crease or petichiae after noninvasive blood pressure measurement ievery 5 minutes for 1 hour Secondary Outcome : factor related truma after noninvasive blood pressure measurement.

Official Title
-----------------
Incidences of Cuff-related Trauma After Noninvasive Blood Pressure Measurement Between With and Without Padding

Conditions
-----------------
Complication

Intervention / Treatment
-----------------
* Device: Padding


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Health volunteer age > 18 or patients Exclusion Criteria: Peripheral vascular disease Difference of blood pressure both arms > 15 mmHg Acute dermal cappillary rupture Phlebitis Skin necrosis Acute radial nerve injury Deep vein thrombosis Rumpel-Leede phenomenon Compartment syndrome

Ages Eligible for Study
-----------------
Minimum Age: 19 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control<br>No padding before application of blood pressure cuff | |
| Experimental: Padding<br>Padding before application of blood pressure cuff | Device: Padding<br>* Padding webrill (Covidian) TM 6<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complication of a non-invasive blood pressure cuff | Petechiae and skin crease | 5 minutes after completion of non-invasive blood pressure measuring |
Kinetics of Circulating Tumoral Cells in Bronchial Primitive Cancer

Study Overview
=================
Brief Summary
-----------------
The pronostic value of Circulating Tumoral Cells(CTC) 's dosage by the method ISET® (tumoral cell isolation by size) in patients with bronchial cancer was previously demonstrated. However, no kinetic study was ever realized to study the value of the CTC as predictive indicator of answer to the therapy. This project plans to study patients in an early stage and patients at advance stage locally moved forward or metastatic of the disease by evaluation of the presence and the number of CTC before every cure. This collaborative and original study should allow to refine the diagnoses of answer and to plan the possible relapses what would allow a premature institution of the treatment.

Official Title
-----------------
Kinetics of Circulating Tumoral Cells in Bronchial Primitive Cancer

Conditions
-----------------
Bronchial Cancer

Intervention / Treatment
-----------------
* Diagnostic Test: ISET® - Isolation by Size of Tumor cells
* Diagnostic Test: ISET® - Isolation by Size of Tumor cells


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with non-small cell lung cancer accepting participation Exclusion Criteria: refusing participation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: early stage bronchial cancer<br>Early stage which can benefit from a surgical resection. A taking will be made in preoperative then in every consultation of follow-up after the intervention | Diagnostic Test: ISET® - Isolation by Size of Tumor cells<br>* early stage bronchial cancer patient will have a blood collection<br>|
| Other: advanced stage bronchial cancer<br>Patients locally moved forward or at a metastatic stage handled by chemotherapy | Diagnostic Test: ISET® - Isolation by Size of Tumor cells<br>* advanced stage bronchial cancer patient will have a blood collection<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| numeration of CTC (circulant tumoral cell) |  | Day 1 |