Insecticide Resistance Management in Burkina Faso and Côte d'Ivoire

Study Overview
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Brief Summary
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This study evaluates the benefit to use 1) insecticidal paints, 2) larvicides, 3) Ivermectin for both human and domestic animals and 4) strengthened Information, Education and Communication (IEC) strategy to complement the universal coverage with LLINs through a cluster randomized trial.

Detailed Description
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Insecticidal paint comprised of two organophosphates (OPs) and an Insect Growth Regulator (IGR). This tool targets adult mosquitoes that are resistant pyrethroids to reduce vector density. Larvicide is a new formulation of Bacillus thuringiensis israelensis that will be implemented in major permanent breeding sites with the objective to reduce vector density. Ivermectin will be injected to domestic animals in addition to the national campaign implemented in the study area which treats the whole population. Ivermectin reduces the survival of mosquito that blood feed on treated humans and animals. Information, Education and Communication strategy aims to increase the adherence of the population to control tools available. Strengthening the IEC aims to increase the good use of long lasting nets.

Official Title
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Insecticide Resistance Management in Burkina Faso and Côte d'Ivoire: Research on Vector Control Strategies

Conditions
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Malaria

Intervention / Treatment
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* Device: Insecticidal paint
* Device: Larvicide
* Biological: Ivermectin
* Behavioral: IEC


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Must be an inhabitant of the villages included into the RCT Aged from 6month old to 20 years old Exclusion Criteria: older than 20 year old

Ages Eligible for Study
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Minimum Age: 6 Months
Maximum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control<br>No intervention | |
| Experimental: insecticidal paint<br>The insecticidal paint contains two organophosphates, chlorpyriphos(1.5%) and diazinon (1.5%), and an insect growth regulator (IGR),pyriproxyfen (0.063%), as active ingredients. | Device: Insecticidal paint<br>* Houses will be painted with insecticidal paint<br>* Other names: Inestfly 5A IGR;|
| Experimental: Larvicides<br>The larvicide is a slow release formulation containing Bacillus thuringiensis Var Israelensis. | Device: Larvicide<br>* Larval breeding sites will be treated with larvicide<br>|
| Experimental: Ivermectin<br>This arm consists in an injectable dose of Ivermectin given to peri-domestic animals. | Biological: Ivermectin<br>* Doses of Ivermectin will be injected to peri-domestic animals<br>|
| Experimental: Information, Education, Communication<br>After a sociological study during the pre-intervention year, this arm will consist in a reinforced communication strategy relative to the nationwide current one | Behavioral: IEC<br>* A reinforced information, education and communication strategy will be implemented.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Malaria incidence | Malaria cases reported in local health system | continuous monitoring during 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Entomological Inoculation Rate | Number of infectious bites/personn | Every 8 weeks during 2 years | 
| Malaria prevalence | % of positive blood smears among the population between 6 months to 20 years | Every 4 months during 2 years |