QUality Of Life and surviVAl in carDIac arreSt Patients

Study Overview
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Brief Summary
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QUO VADIS is a national observational study with the aim to describe clinical intervention and utilization of neuroprognostication tools in the management of patients admitted to ICU following cardiac arrest

Detailed Description
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Despite recent improvements in post-resuscitation care, about 50% of patients resuscitated from cardiac arrest die or have poor neurological prognosis. Post-anoxic brain injury is common after cardiac arrest and is a major cause of post-resuscitation mortality. Since there has been a significant investment in improving the emergency response to both in-hospital ad out-of-hospital cardiac arrest (IHCA and OHCA, respectevly) patients and reported improvements in short-term survival outcomes, the long-term neurological state and quality of life of survivors and their caregiver is of growing significance. QUO VADIS is a national observational study created to describe clinical interventions and utilization of neuroprognostication tools in the management of patients admitted to ICU following cardiac arrest. The aims of the study are: To create an Italian Registry that describes clinical interventions and neuroprognostication tools used in the management of patients admitted to ICU following cardiac arrest To evaluate, after one year from the cardiac arrest, the neurological outcome and the quality of life of the patients; To evaluate, after one year from the cardiac arrest, the quality of life of caregivers; To identify the most effective clinical intervention in the management of post-cardiac arrest patients admitted to ICU; To create a prognostic model for patients admitted to ICU after cardiac arrest.

Official Title
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QUO VADIS - QUality Of Life and surviVAl in carDIac arreSt Patients

Conditions
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Cardiac Arrest, Post-Anoxic Coma, Central Nervous System Diseases

Intervention / Treatment
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* Other: Intensive care treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥ 14 years; Cardiac Arrest within 24 hours ICU admission Exclusion Criteria: Absence of Informed consent; Age < 14 years

Ages Eligible for Study
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Minimum Age: 14 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cardiac arrest patients admitted to Intensive Care treatment<br>Intensive Care treatment; Utilization of neuroprognostication tools | Other: Intensive care treatment<br>* Intensive care treatment; Utilization of neuroprognostication tools<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disability | GOSe (Glascow Outcome Scale extended). Minimum value: 1 = Dead; Maximum value: 8= Upper Good Recovery | 6 months | 
| Neurological Outcome | mRS (modified Ranking Scale) Minimum value: 0 = Complete recovery; Maximum value: 6 = Death | 6 months | 
| Patients quality of life | EuroQoL-5D (european quality of life 5 dimensions). 0 = Worst imaginable health state; 100 = best imaginable health state | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Caregiver quality of life | Caregiver Burden Inventory. 0 to 20 = little or no burden; 61 to 88 = severe burden | 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Comparative Effectiveness Research