A Prospective, Multicenter Registry With Targeted Temperature Management After Out-of-hospital Cardiac Arrest in Korea

Study Overview
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Brief Summary
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Therapeutic hypothermia after out-of-hospital cardiac arrest is considered as a standard care. However, optimal candidates, optimal dose, duration, timing of initiation and rate of rewarming is still unknown. The objective of this project is to improve the outcomes for patients after resuscitation from out-of-hospital cardiac arrest treated with therapeutic hypothermia established from the analysis of multicenter registry data.

Official Title
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A Prospective, Multicenter Registry With Targeted Temperature Management After Out-of-hospital Cardiac Arrest in Korea

Conditions
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Out-of-Hospital Cardiac Arrest

Intervention / Treatment
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* Other: not provided


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age of older than 18 years out-of-hospital cardiac arrest comatose mentality after return of spontaneous circulation (ROSC) treated with therapeutic hypothermia, regardless of target temperature Exclusion Criteria: suspected or confirmed to cerebrovascular accident poor pre-arrest neurologic status (CPC>3) patients who are terminally ill or for whom intensive care dose not seem to be appropriate Do not attempt resuscitation (DNAR) order patients with tympanic membrane temperature below 30 degree celsius on admission

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: not provided|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| survival |  | 6 months after cardiac arrest | 
| Neurologic Outcome | Cerebral Performance Category (CPC). CPC 1,2 : Good Outcome CPC 3,4,5 : Poor Outcome | 6 months after cardiac arrest | 
| Neurologic Outcome | modified Rankin Scale (mRS) mRS 0,1,2, 3 : Good Outcome mRS 4,5,6 : Poor Outcome | after 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| survival |  | duration of hospitalization, limit 180 days | 
| neurological outcome | Cerebral Performance Category (CPC). CPC 1,2 : Good Outcome CPC 3,4,5 : Poor Outcome | duration of hospitalization, limit 180 days | 
| neurological outcome | modified Rankin Scale (mRS) mRS 0,1,2, 3 : Good Outcome mRS 4,5,6 : Poor Outcome | duration of hospitalization, limit 180 days | 
| Survival |  | 1 month after cardiac arrest | 
| neurological outcome | Cerebral Performance Category (CPC). CPC 1,2 : Good Outcome CPC 3,4,5 : Poor Outcome | 1 month after cardiac arrest | 
| neurological outcome | modified Rankin Scale (mRS) mRS 0,1,2, 3 : Good Outcome mRS 4,5,6 : Poor Outcome | 1 month after cardiac arrest | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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therapeutic hypothermia