linjc16/ctgov huggingface dataset:
Efficacy and Safety Study of Bendamustine With or Without Rituximab in Chronic Lymphoproliferative Disorders

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is collect and evaluate the clinical experience reached in Italy on the use of bendamustine alone or combined with rituximab as treatment of patients with relapsed or refractory chronic lymphoproliferative disorders.

Detailed Description
-----------------
All patients who meet the criteria for inclusion will be included in the study. A specific database will be created to collect the following information: personal data, medical history, histology related to the underlying disease, comorbidities, laboratory data, initial staging, data on the dosage and the number of cycles administered, the recorded toxicity data, the clinical response and the main events (relapse, progression, death, and cause of death). These data will then be retrospectively examined in order to obtain information about the life-saving treatment.

Official Title
-----------------
A Retrospective Multicenter Trial on Efficacy and Toxicity of Bendamustine Alone or Associated With Rituximab, As Salvage Therapy in Patients With Chronic Lymphoproliferative Disorders

Conditions
-----------------
Chronic Lymphocytic Leukaemia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with relapsed or refractory chronic lymphoproliferative disorders salvage treatment with Bendamustine +/- Rituximab age ≥ 18 years Exclusion Criteria: previous treatment with Bendamustine

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall Response Rate (ORR) | Evaluate the activity of Bendamustine +/- Rituximab in term of ORR | At least 2 months after completion of therapy | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression Free Survival (PFS) and Overall Survival (OS) | Evaluate the activity of Bendamustine +/- Rituximab in term of PFS and OS | From the date of frist treatment cycle until the date of first documented progression or date of death for any cause, whichever came first, assessed up to 150 months | 
| Number of Adverse Events | Assess to efficacy of Bendamustine +/- Rituximab in term of grade III and IV National Cancer Institute Common Toxicity Criteria (NCI CTC) adverse events | From the date of first tratment cycle until 6 months after the date of last treatment cycle |
Development of an Screening System in Children With Congenital Heart Disease Based on Cloud Computing and Big Data

Study Overview
=================
Brief Summary
-----------------
This study intends to establish an automatic system for screening on children with congenital heart disease, the system include the auscultation of cardiac murmur and the test of oxygen saturation, the data was analyzed based on the cloud computing.

Detailed Description
-----------------
This study intends to establish a system for screening of children with congenital heart disease,with the combination of cardiac auscultation , the test of oxygen saturation, the use of cloud computing and data base. The investigators decide to do this project from three main points.1:How to establish a data-base system? 2:How to get heart sound signal? 3.How to analyze so many signals?

Official Title
-----------------
Development of an Screening System in Children With Congenital Heart Disease Based on Cloud Computing and Big Data

Conditions
-----------------
Heart Diseases

Intervention / Treatment
-----------------
* Device: automatic screening machine on congenital heart disease


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Neonatal ward patients Patients with echocardiography reports Exclusion Criteria: Severe pneumonia

Ages Eligible for Study
-----------------
Maximum Age: 10 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: automatic screening machine on congenital heart disease|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Positive Predictive Value | The ratio of truly congenital heart disease cases divide by the total positive cases detected by the screening test. | 2days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
fetal heart sounds, big data, cloud computing, congenital heart disease, data base, Acoustic structure design
the Relationship Between Helicobacter Pylori Infection and Irritable Bowel Syndrome

Study Overview
=================
Brief Summary
-----------------
Evaluating any possible relationship between irritable bowel syndrome occurrence and Helicobacter pylori infection

Official Title
-----------------
Evaluation of the Relationship Between Helicobacter Pylori Infection and Irritable Bowel Syndrome

Conditions
-----------------
Irritable Bowel Syndrome

Intervention / Treatment
-----------------
* Diagnostic Test: H. pylori stool antigen


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients will be selected according to Rome IV criteria for the diagnosis of IBS, which include: Recurrent abdominal pain at least 1 day/week in the last 3 months, with two or more of the following criteria: Related to defecation Associated with a change in frequency of stool Associated with a change in form of stool. Criteria achieved for the last 3 months with symptom onset at least 6 months before diagnosis Exclusion Criteria: • Rectal bleeding Anemia Weight loss Onset after 50 years of age Recent antibiotic use Abnormal abdominal examination (organomegaly, lump) Family history of colorectal cancer. Family history of inflammatory bowel disease, or celiac disease.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1<br>patients with Irritable Bowel Syndrome | Diagnostic Test: H. pylori stool antigen<br>* using H. pylori antigen kits in stool<br>|
| Group 2<br>normal | Diagnostic Test: H. pylori stool antigen<br>* using H. pylori antigen kits in stool<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of irritable bowel syndrome patients who had H.pylori infection | H.pylori stool antigen kits | through study completion, an average of 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Helicobacter Pylori, Irritable Bowel Syndrome
Cardiovascular Disease in Black Versus White Physicians

Study Overview
=================
Brief Summary
-----------------
To examine the natural histories of coronary artery disease and hypertension in cohorts of Black and white men of identical education and occupations.

Detailed Description
-----------------
BACKGROUND: Prior studies of Black-white differences in hypertension and coronary disease have compared racial groups from markedly different socioeconomic and educational backgrounds. This study represented one of a few, if any, long term prospective studies of cardiovascular disease in middle-class Blacks and whites of similar education and occupation, in whom both youthful and midlife risk factors were assessed. DESIGN NARRATIVE: In this prospective study, the prevalence and incidence of coronary artery disease, hypertension, and other cardiovascular diseases were compared using standardized endpoint criteria. The prevalence of cardiovascular risk factors in midlife were compared between cohorts, and included smoking, diabetes, family history, dietary factors, and lipoprotein cholesterol levels. The youthful predictors of midlife cardiovascular risk factors were determined using baseline data collected by identical protocols in the two cohorts between 1957 and 1965. The youthful risk factors were related to the incidence of disease in midlife in two cohorts to identify differences in significance, independence, and relative importance of risk factors in Blacks versus whites. The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System (PRS) record.

Conditions
-----------------
Cardiovascular Diseases, Coronary Disease, Heart Diseases, Hypertension

Participation Criteria
=================
Eligibility Criteria
-----------------
No eligibility criteria

Ages Eligible for Study
-----------------
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Cross-sectional Study to Investigate the Effects of Chronic Obstructive Pulmonary Disease on Daily Life Activities

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to investigate the effects of Chronic Obstructive Pulmonary Disease (COPD) on daily life activities in patients with COPD and also to determine the socio-demographic profile, daily life style and needs of the patients with COPD.

Official Title
-----------------
Cross-sectional Observational Study to Investigate the Effects of Chronic Obstructive Pulmonary Disease on Daily Life Activities

Conditions
-----------------
Chronic Obstructive Pulmonary Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of COPD Outpatient treatment for any reason Current or ex-smoker Exclusion Criteria: An exacerbation of COPD that still lasts or that was experienced within last 3 months History of asthma and/or allergic rhinitis The presence of another important respiratory disease

Ages Eligible for Study
-----------------
Minimum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with COPD<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect of COPD on daily activities | The distribution of the patients according to their answers, as Yes / No / Unknown, given to the questions of patient questionnaire about the effect of COPD on daily life and which daily activities are limited will be calculated as percentage. | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patients' socio-demographic profiles, daily life conditions and needs and expectations from therapy | The answers the patients give to the questions about socio-demographic profiles, daily life conditions and needs and their expectations from the therapy will be summarized as percentages: Age and gender, educational background, place of residence, marital status and life conditions, concomitant diseases, smoking status, the diagnosis of COPD and its clinical characteristics basic knowledge of the patient about COPD daily life of the patient, expectations from the therapy. | Baseline | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
COPD
The Pilot Study of Chikungunya Virus Infections in Southern Taiwan

Study Overview
=================
Brief Summary
-----------------
This test is to be collected during the dengue outbreak samples, including samples back in the past and forward to close the case, investigating the prevalence of serum Chikungunya virus infection, and against those suspected dengue fever, Chikungunya disease-related tests conducted to clarify dengue and Chikungunya disease of clinical judgment, rapid method to detect Chikungunya virus and then develop.

Detailed Description
-----------------
During the execution of this project was ended March 1, 2012 to December 31, 2015, is expected to gather 300 suspected dengue infection, of whom 150 dengue-negative test results, test results of 150 dengue positive. And closed the case into prospective and retrospective analysis of the last sample into two parts. Case closed after part of a prospective analysis of the study, subjects were required to complete consent forms and collect 20 ml blood samples, blood samples will be checked to identify dengue and Chikungunya disease associated serum antigen-antibody reaction , PCR (polymerase chain reaction) test and sequence analysis and pathogen identification and separation, in order to identify the source of infection difference. In addition, retrospective analysis of the last part of the specimen, sucked after the health of the host track dengue infection, host immune regulation changes, and possible interactions with viral hepatitis (KMUH-IRB-960195) collected by the inspection plan body, the number of samples included in the plan to close the case, and contact with the subjects, changes to inform the content of the plan to re-sign the consent form.

Official Title
-----------------
Investigate the Prevalence of Serum Chikungunya Virus Infection, and Against Those Suspected Dengue Fever, Chikungunya Disease-related Tests Conducted

Conditions
-----------------
Chikungunya Fever

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Suspected of being infected with dengue fever Exclusion Criteria: none
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| For persons with suspected dengue fever, Chikungunya disease-related testing conducted to clarify the clinical dengue and Chikungunya disease of judgment | The project expects to help physicians understand overview of Taiwan Chikungunya epidemic diseases and assisting their clinical judgment. Hope to establish a complete ilk disease and clinical information, and then establish a rapid detection of Chikungunya virus. | 75 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Chikungunya fever, Chikungunya Virus
Extraction of Impacted 3rd Molars, Can Bone Support of the Second Molar be Promoted by a Bio-Oss Graft?

Study Overview
=================
Brief Summary
-----------------
A prospective study examining bilateral 3rd molar extraction, by a split mouth protocol the investigators augment unilaterally and compare periodontal parameters in between.

Detailed Description
-----------------
40 patients will undergo bilateral 3rd molar extractions, in each patient one side would be augmented by a Bio-Oss xenograft. Post operative, periodontal parameters such as pocket depth and mobility will be evaluated and compared.

Official Title
-----------------
Extraction of Impacted 3rd Molars, Can Bone Support of the Second Molar be Promoted by a Bio-Oss Graft?

Conditions
-----------------
Impacted Third Molar Tooth

Intervention / Treatment
-----------------
* Drug: Geistlich Bio Oss


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Bilateral impacted 3rd molars. Healthy individuals Exclusion Criteria: Smokers Alcohol abusers Pregnancy
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 3rd molar<br>Drug: Geistlich Bio Oss | Drug: Geistlich Bio Oss<br>* Extraction of Impacted 3rd Molars,<br>* Other names: Bone Support;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mobility (Scale 0,1,2,3), change is being assessed. | Mobility will be assessed in the intervals mentioned above, and compared over time. | Pre opp (base line), 1 month post opp, 3 months post opp, 6 months post opp | 
| Pocket Depth (mm), change is being assessed. | Pocket depth will be assessed in the intervals mentioned above, and compared over time. | Pre opp (base line), 1 month post opp, 3 months post opp, 6 months post opp |
Prognostic Factors After Liver Transplantation

Study Overview
=================
Brief Summary
-----------------
The study retrospectively reviewed the medical records of patients who received adult liver transplantation in Changhua Christian hospital from 2002 to 2019. We collected their personal data about liver disease, laboratory data about liver function, pre-transplant evaluation and post-transplant outcome. We investigate what prognostic factors may contribute a good survival outcome, and improve our clinical practice.

Official Title
-----------------
Prognostic Factors After Liver Transplantation

Conditions
-----------------
Liver Diseases, Liver Transplant; Complications

Intervention / Treatment
-----------------
* Procedure: liver transplantation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients who received adult liver transplantation in Changhua Christian hospital from 2002 to 2019 Exclusion Criteria: patients who did not have suitable donor for liver transplantation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Liver transplant<br> | Procedure: liver transplantation<br>* liver transplantation for chronic liver disease or acute liver failure<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of participants with morbidity and mortality after surgery | post-operative complications which requiring interventions, related to organ failure and hospital mortality | upto one month after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| long-term survival rate | 1,5 year survival rate | upto 5 years after surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
viral hepatitis, alcoholic liver disease, liver transplantation, chronic liver disease
Development of a Genetic Counseling Patient Preference Intervention for Women at Elevated Risk for Breast Cancer

Study Overview
=================
Brief Summary
-----------------
This study develops a genetic counseling patient preference intervention for women at elevated risk for breast cancer. This study aims to develop an intervention that may deliver educational videos about breast cancer, heredity, multigene tests results and polygenic risk score, provide multigene and polygenic test results, obtain information about patients' questions/ concerns about test results to use in post-genetic test counseling, and determine patient preference (e.g. telephone) for receipt of post-genetic test counseling.

Detailed Description
-----------------
PRIMARY OBJECTIVE: I. Develop the Genetic Counseling Patient Preference (GCPP) intervention in collaboration with community members. OUTLINE: Participants attend a focus group over 90-120 minutes providing feedback on GCPP intervention.

Official Title
-----------------
Development of a Genetic Counseling Patient Preference Intervention for Women at Elevated Risk for Breast Cancer

Conditions
-----------------
Breast Carcinoma

Intervention / Treatment
-----------------
* Procedure: Discussion


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Female Ages 35-64 Known elevated risk for breast cancer The ability to speak and read English Provide written consent

Ages Eligible for Study
-----------------
Minimum Age: 35 Years
Maximum Age: 64 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Observational (focus group)<br>Participants attend a focus group over 90-120 minutes providing feedback on GCPP intervention. | Procedure: Discussion<br>* Attend a focus group<br>* Other names: Discuss;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Development of Genetic Counseling Patient Preference (GCPP) intervention |  | Up to 2 years |