A New Marker for Early Diagnosis of Pneumoperitoneum-Related Acute Kidney Injury: Insulin-Like Growth Factor-1 (IGF-1)

Study Overview
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Brief Summary
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In our study, to show the effect of pneumoperitoneum on acute kidney injury in patients scheduled for laparoscopic surgery, NGAL and IGF-1 values will be measured before, after and 24 hours after pneumoperitoneum, and these values will be compared. In our study, we aimed to investigate the effect of pneumoperitoneum applied on acute kidney injury in patients who underwent laparoscopic surgery. Creatinine and NGAL have been used successfully in the follow-up of acute kidney injury. Our study investigates whether IGF-1 will be an effective indicator in acute kidney injury by comparing IGF-1 and NGAL values before pneumoperitoneum, after pneumoperitoneum and at the postoperative 24th hour.

Official Title
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A New Marker for Early Diagnosis of Pneumoperitoneum-Related Acute Kidney Injury: Insulin-Like Growth Factor-1 (IGF-1)

Conditions
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Acute Kidney Injury (Nontraumatic), Pneumoperitoneum

Intervention / Treatment
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* Diagnostic Test: IGF-1


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged 18-70 years of both sexes ASA I-III Patients Exclusion Criteria: Obesity, Chronic Kidney Disease, Chronic Renal Failure, Acute Renal Failure, Peripheral and ischemic vascular disease, Chronic Heart Failure, History of anaphylaxis, A-V block, Creatinine level >1.4, Neuromuscular disease, Malignant hypertension, Pyelonephritis, Urinary tract infectio, Severe inflammation/possible sepsis, Active malignancy, Patients with surgery reversion to laparotomy, Hemodynamic instability, need for vasopressors, Severe bleeding requiring blood transfusion,

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: IGF<br>Creatinine and NGAL have been used successfully in the follow-up of acute kidney injury. In our study, in order to show the effect of pneumoperitoneum on acute kidney injury in patients scheduled for laparoscopic surgery, NGAL and IGF-1 values will be measured before, after and 24 hours after pneumoperitoneum, and these values will be compared. | Diagnostic Test: IGF-1<br>* We need to diagnose acute kidney injury in the early postoperative period. The markers examined so far do not provide enough information to diagnose acute kidney injury early. For this reason, many different biomarkers are used in the early diagnosis of acute kidney injury in many parts of the world. Thanks to our research, we can recognise the development of acute kidney injury at an early stage and determine whether a previously unused biomarker (IGF-1) is effective in the early diagnosis of acute kidney injury.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnosis of acute kidney injury in the early postoperative period with IGF-1 (insulin like growth factor-1) | The researchers investigate whether IGF-1 will be an effective indicator in acute kidney injury by comparing IGF-1 and NGAL (Neutrophil gelatinase-associated lipocalin) values before pneumoperitoneum, after pneumoperitoneum and at the postoperative 24th hour. | before pneumoperitoneum, after pneumoperitoneum, and at the postoperative 24th hour. |