Utility of Whole-body MRI in the Detection of Traumatic Injuries of Undetermined Origin in Children

Study Overview
=================
Brief Summary
-----------------
The diagnosis of abuse in children relies heavily on the presence of skeletal and extraskeletal injuries. However, some lesions are not seen by initial skeletal survey. And the investigators have to complete the skeletal survey with either bone-scan or CT scan or whole-body MRI. whole-body MRI has proved its worth in the pediatric population for the evaluation of skeletal and extraskeletal lesions in children with cancer or infectious diseases. Thus, whole-body MRI would allowed to have total picture of children without ionising radiation exposure.

Official Title
-----------------
Utility of Whole-body MRI (STIR and Diffusion Weighted) in the Detection of Traumatic Injuries of Undetermined Origin in Children

Conditions
-----------------
Traumatic Injuries

Intervention / Treatment
-----------------
* Other: diagnostic whole body MRI


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Infant hospitalised for sub-dural hematoma or skeletal injuries due to non accidental traumatism or skin lesions or abdominal injuries of undetermined origin Exclusion Criteria: Sub-dural hematoma of accidental origin or skeletal injuries of accidental Origin or known origin of lesions. Subject already included in the study

Ages Eligible for Study
-----------------
Maximum Age: 3 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: whole body MRI<br>diagnostic whole body MRI, and skeletal imaging following guidelines (whole body radiographic and scintigraphic screening) | Other: diagnostic whole body MRI<br>* diagnostic whole body MRI, both STIR and diffusion weighted<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| sensibility of MRI for detecting skeletal injuries | standard skeletal imaging is used as reference | one week | 
| positive predictive value of MRI for detecting skeletal injuries | standard skeletal imaging is used as reference | one week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| sensibility of MRI for detecting children with skeletal injuries | standard skeletal imaging is used as reference | one week | 
| specificity of MRI for detecting children with skeletal injuries | standard skeletal imaging is used as reference | one week | 
| predictive positive value of MRI for detecting children with skeletal injuries | standard skeletal imaging is used as reference | one week | 
| predictive negative value of MRI for detecting children with skeletal injuries | standard skeletal imaging is used as reference | one week | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
traumatic injuries, Whole-body MRI, Skeletal survey, Children, Diagnostic