Assessment of Relationship Between Preoperative Nutritional Status and Perioperative/Postoperative Conditions in Patients With Lung Cancer Scheduled for Lobectomy

Study Overview
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Brief Summary
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Malnutrition is common in patients with lung cancer. In patients with malnutrition risk, the risk of complications is high both in the perioperative, early and late postoperative periods. Malnutrition is an independent risk factor for length of hospital stay and cost in these patients. Patients with lung cancer may have many morbidities in postoperative period, especially problems with wound healing. Therefore, assessment of the nutritional status of patients with lung cancer should begin at the diagnosis stage.

Detailed Description
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In patients with lung cancer scheduled for lobectomy, anthropometric measurements will be measured and the results of laboratory tests(albumin, prealbumin, creatinine, total lymphocyte count, C reactive protein), Nutritional Risk Screening-2002, Nutritional Risk Index, Mini Nutritional Assessment, Glasgow Prognostic Score, Prognostic Nutritional Index and neoadjuvant chemotherapy or not will be recorded in 72 hours before surgery. In addition, demographic information of the patients (name, surname, identification number, age, comorbidity, American Society of Anesthesiologists score) will be recorded. After the information is given to the patients, their written and verbal consent will be obtained. In the operating room, routine monitoring (electrocardiography, invasive blood pressure measurement, arterial blood gas monitoring, peripheral oxygen saturation, end-tidal carbon dioxide measurement by capnography) will be applied to the patients in accordance with the standard protocol for elective lobectomy surgery. Hemodynamic changes (eg. dysrhythmia, hypotension, hypertension, hemorrhage), metabolic status (pH, bicarbonate, base excess), lactate, glucose level in blood gas evaluation and intraoperative complications will be recorded during the intraoperative period. In the postoperative period, length of stay in the intensive care unit, length of hospital stay, early complications (eg. dysrhythmia, acute coronary syndrome, sepsis, mediastinitis, pneumonia, surgical site infection, prolonged air leak), time to start oral intake and transition to adequate oral intake will be recorded in the one-month postoperative period.

Official Title
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Assessment of Relationship Between Preoperative Nutritional Status and Perioperative/Postoperative Conditions in Patients With Lung Cancer Scheduled for Lobectomy

Conditions
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Lung Cancer, Malnutrition, Nutritional Deficiency

Intervention / Treatment
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* Diagnostic Test: Nutritional Risk Screening-2002
* Diagnostic Test: Nutritional Risk Index
* Diagnostic Test: Mini Nutritional Assessment
* Diagnostic Test: Glasgow Prognostic Score
* Diagnostic Test: Prognostic Nutritional Index
* Diagnostic Test: Anthropometric measurements
* Device: Handgrip strength test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Having a diagnosis of lung cancer Lung lobectomy operation will be performed 18 years and older patients Having an American Society of Anesthesiologists score of 1, 2, 3 Having approved and signed the informed consent form Exclusion Criteria: Patients who underwent lobectomy with a diagnosis other than lung cancer Patients younger than 18 years Patients with an American Society of Anesthesiologists score of 4 and above Patients who did not accept informed consent Patients who refused to participate in the study

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Lung cancer scheduled lobectomy<br> | Diagnostic Test: Nutritional Risk Screening-2002<br>* Nutritional Risk Screening-2002<br>Diagnostic Test: Nutritional Risk Index<br>* Nutritional Risk Index<br>Diagnostic Test: Mini Nutritional Assessment<br>* Mini Nutritional Assessment<br>Diagnostic Test: Glasgow Prognostic Score<br>* Glasgow Prognostic Score<br>Diagnostic Test: Prognostic Nutritional Index<br>* Prognostic Nutritional Index<br>Diagnostic Test: Anthropometric measurements<br>* middle arm circumference<br>Device: Handgrip strength test<br>* Handgrip strength test<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative complications | dysrhythmia, acute coronary syndrome, sepsis, mediastinitis, pneumonia, surgical site infection, prolonged air leak | a month after the surgery | 
| Length of stay in the intensive care unit | Length of stay in the intensive care unit | up to 30 days | 
| Length of hospital stay | Length of hospital stay | up to 30 days | 
| Intraoperative hemodynamic complications | dysrhythmia, hypotension, hypertension, hemorrhage | during the procedure | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Oral intake | time to start oral intake and transition to adequate oral intake | up to 30 days | 
| pH | pH in arterial blood gas evaluation | during the procedure | 
| bicarbonate | bicarbonate level in arterial blood gas evaluation | during the procedure | 
| base excess | base excess in arterial blood gas evaluation | during the procedure | 
| lactate | lactate level in arterial blood gas evaluation | during the procedure | 
| glucose | glucose level in arterial blood gas evaluation | during the procedure |