linjc16/ctgov huggingface dataset:
The Relationship Between Drainage Fluid and Anastomotic Leakage After Colorectal Cancer Surgery

Study Overview
=================
Brief Summary
-----------------
A prospective and analytical study on the detection of early anastomotic leakage by abdominal drainage fluid after colorectal cancer surgery. pay attention to indicators including bilirubin

Official Title
-----------------
A Prospective and Analytical Study on the Detection of Early Anastomotic Leakage With Abdominal Drainage Fluid After Colorectal Cancer Surgery

Conditions
-----------------
Anastomotic Leakage

Intervention / Treatment
-----------------
* Diagnostic Test: drainge fluid


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1) Preoperative pathologically confirmed colorectal adenocarcinoma; 2) Patients undergoing minimally invasive (robot or laparoscopic) tumor resection + bowel anastomosis; 3) Age: 18 to 80 years old; 4) Preoperative TNM staging (whole abdomen) Enhanced CT or MRI, laparoscopic exploration): cT1-3bN0-2M0; 5) Preoperative ASA score: ≤Ⅲ; 6) No history of malignant tumors and no other malignant tumors by preoperative examination; 7) Not accepted before surgery Deterministic treatment, such as radiotherapy, chemotherapy or immunotherapy; 8) No pre-existing ascites was found before and during the operation; 9) Informed consent signed by the patient or his agent Performance status (ECOG) 0 1 Exclusion Criteria: 1) Patients with obstructive jaundice or other congenital disorders of bile acid synthesis and metabolism; 2) Severe abdominal cavity infection and other infections; 3) A large amount of abdominal effusion was found before and during the operation; 4) Tumor was confirmed during the operation For T4b or intraoperative detection of other tumors, joint resection or distant metastasis is required; 5) Intraoperative conversion to laparotomy; 6) Intraoperative change of surgical method to perform Miles or Hartmann surgery; 7) Intraoperative and postoperative abdominal cavity Hyperthermic perfusion chemotherapy.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: drainge fluid|including bilirubin|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| leakage |  | 10days |
American Joint Replacement Registry

Study Overview
=================
Brief Summary
-----------------
The American Joint Replacement Registry is a not-for-profit 501(c)(3) organization for data collection and quality improvement initiatives for total hip and knee replacements. The AJRR is a collaborative effort supported by the American Academy of Orthopaedic Surgeons (AAOS), the American Association of Hip and Knee Surgeons (AAHKS), The Hip Society, The Knee Society, hospitals, health insurers, medical device manufacturers, and contributions from individual orthopaedic surgeons.

Official Title
-----------------
American Joint Replacement Registry

Conditions
-----------------
ARTHROPLASTY, REPLACEMENT

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Any individual in the US undergoing total joint arthroplasty Exclusion Criteria: None
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Health Related Quality of Life | Utilization of VR-12 and/or PROMIS-10 | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hip disability and Osteoarthritis Outcome Score - Joint Replacement (HOOS, JR) |  | 12 months |
Nano-hydroxyapatite and Ozone - Effect on Approximal Initial Caries

Study Overview
=================
Brief Summary
-----------------
Objectives: to assess the efficiency of three methods of enamel remineralization on initial approximal caries: 1. a nano-hydroxyapatite gel, 2. gaseous ozone therapy 3. combination of a nano-hydroxyapatite gel and ozone. Materials and Methods: Patients (n=92, age 20-30y) with initial approximal enamel lesions on premolar and molar teeth (n=546) randomly allocated to three groups subjected to a 6-months treatment: Group I: domestic nano-hydroxyapatite remineralizing gel, group II: in-office ozone therapy, group III: both remineralizing gel and ozone therapy. Caries lesions assessed on bitewing radiographs at baseline, after 1 year and after 2 years.

Official Title
-----------------
Influence of Nano-hydroxyapatite and Ozone on Approximal Initial Caries

Conditions
-----------------
Caries,Dental

Intervention / Treatment
-----------------
* Other: ApaCare & Repair


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: -initial approximal enamel lesions on premolar and molar teeth Exclusion Criteria: distal surface of the last tooth in arch, overlapping teeth fillings on approximal surfaces of teeth of interest ongoing orthodontic therapy with braces or other appliances

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 30 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: domestic nanohydroxyapatite gel ApaCare & Repair<br>6-months treatment, caries lesions were assessed on bitewing radiographs at baseline, after 1 year and after 2 years | Other: ApaCare & Repair<br>* Initial cariuos lesions were treated.<br>* Other names: OzonyTron;|
| Experimental: in-office ozone therapy OzonyTron<br>6-months treatment, caries lesions were assessed on bitewing radiographs at baseline, after 1 year and after 2 years | Other: ApaCare & Repair<br>* Initial cariuos lesions were treated.<br>* Other names: OzonyTron;|
| Experimental: both remineralizing gel and ozone therapy<br>6-months treatment, caries lesions were assessed on bitewing radiographs at baseline, after 1 year and after 2 years | Other: ApaCare & Repair<br>* Initial cariuos lesions were treated.<br>* Other names: OzonyTron;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Remineralizing effect | Caries lesions were assessed on bitewing radiographs | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Remineralizing effect - follow-up | Caries lesions were assessed on bitewing radiographs | after 1 year and after 2 years |
PET Perfusion Imaging Techniques and Comparing Them to CT Perfusion Imaging in Stroke

Study Overview
=================
Brief Summary
-----------------
Adult patients who are diagnosed with an acute supratentorial ischemic stroke within 48 hrs of onset will be enrolled into the study. Participants will undergo both a CT Scan and PET scan within 7 days of onset. Participants will have the option to undergo a second PET scan with fluorodeoxyglucose (FDG).

Detailed Description
-----------------
Patients older than 18 years of age diagnosed with an acute supratentorial ischemic stroke within 48 hrs of symptom onset will be prospectively enrolled. Research imaging will be obtained before 7 days after symptom onset. The patient will receive the standardized treatment protocol at the hospital. Informed consent will be obtained from each patient or a substitute decision maker for each individual imaging study (CTP, Rb PET, and FDG PET). The patient will be given the option of undergoing the CTP imaging with the Rb PET only or both the Rb PET and FDG PET components.

Official Title
-----------------
Developing PET Perfusion Imaging Techniques and Comparing Them to CT Perfusion Imaging in Stroke Patients

Conditions
-----------------
Acute Ischemic Stroke

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age: >18 yo Gender: male or female Acute (within 7 days from symptom onset) Supratentorial Ischemic Stroke Exclusion Criteria: 1) Planned surgical intervention 2) Severely abnormal blood glucose level (will be excluded from FDG PET imaging) 3) Unable to undergo CTP or PET imaging (i.e. claustrophobia) 4) Pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Compare PET brain perfusion imaging to CTP | Imaging of CTP images with the Rb PET only or both the Rb PET and FDG PET with CTP imaging components to evaluate blood flow and metabolism mismatches. | through study completion, 1 year from start of recruitment |
Ergometer Cycling After Replacement of the Hip or Knee Joint

Study Overview
=================
Brief Summary
-----------------
Despite the widespread use of hip and knee replacement surgery, there is a considerable lack of consensus regarding postoperative treatment and rehabilitation, mostly because of the lack of well-designed studies testing the efficacy and effectiveness of such practices. In particular there are no recommendations regarding the use of ergometer cycling after hip or knee replacement surgery. Therefore the investigators initiated a multicenter controlled clinical trial evaluating the effect of ergometer cycling versus no ergometer cycling after hip or knee replacement surgery.

Official Title
-----------------
A Multicenter Randomized Controlled Trail of Ergometer Cycling After Hip and Knee Replacement Surgery

Conditions
-----------------
Osteoarthritis

Intervention / Treatment
-----------------
* Behavioral: Ergometer Cycling
* Behavioral: No ergometer cycling


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient who is about to receive unilateral hip or knee replacement surgery on an elective basis of diagnosis of osteoarthritis or femoral head necrosis Exclusion Criteria: A history of septic arthritis Hip fracture Intraoperative complications History of implant surgery on the joint to be operated on Rheumatoid arthritis Amputations Inability of complete the questionnaires because of cognitive or language difficulties

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Ergometer Cycling|Ergometer Cycling under the guidance of a physical therapist after the second postoperative week. These training sessions were scheduled to be performed three times a week for a time period of at least three weeks. The resistance of the ergometer was set to a minimum (for example 30 Watts). Physical therapists were informed to pay special attention, that the height of the saddle is set so that the forefoot reaches the pedal with the knee in extension.|
|Behavioral: No ergometer cycling|Patients of the no ergometer cycling group did not receive any ergometer cycling after surgery|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| WOMAC Physical Function |  | 3 months to 24 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| WOMAC Pain and Stiffness |  | 3 months to 24 months | 
| SF-36 |  | 3 months to 24 months | 
| Patient satisfaction |  | 3 months to 24 months | 
| Lequesne Hip or Knee Score |  | 3 months to 24 months |
Adrenaline During Resuscitation From Pulseless Electrical Activity

Study Overview
=================
Brief Summary
-----------------
This is a prospective observational study at St. Olavs hospital in Norway. Data are gathered from defibrillators that have been in use during resuscitation from cardiac arrest. Aim is to investigate the changes in electrocardiograms (ECG) during resuscitation from pulseless electrical activity (PEA), which is a type of cardiac arrest. ECG changes may be useful as a prognostic marker during resuscitation from PEA. In addition the researchers will describe the effect of adrenaline and chest compressions on clinical state transitions during resuscitation from pulseless electrical activity. Clinical state transitions are changes between different types of cardiac arrest. This study is expected to increase our understanding of the dynamics during treatment of cardiac arrest.

Official Title
-----------------
Adrenaline During Resuscitation From Pulseless Electrical Activity

Conditions
-----------------
Heart Arrest

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Cardiac arrest among hospitalized patients presenting with PEA as the primary rhythm.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with primary PEA.<br>Patients at St. Olavs hospital who suffer cardiac arrest and pulseless electrical activity (PEA) as primary rhythm during 2018-2021. 120 episodes from St. Olavs hospital were collected previously (2010-2013). In addition 200 cases will be available from the hospital of The University of Pennsylvania, Philadelphia, USA. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| QRS frequency | Measurement of RR intervals in milliseconds. | Every 3 minutes from start till end of cardiopulmonary resuscitation | 
| QRS width | Measurement of the width of QRS complexes in milliseconds | Every 3 minutes from start till end of cardiopulmonary resuscitation | 
| Changes of clinical states | changes of clinical states (for example from Pulseless electrical activity to Ventricular fibrillation) during treatment of cardiac arrest. | Every 3 minutes from start till end of cardiopulmonary resuscitation | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Epinephrine, Pulseless electrical activity
Evaluation of Neuroinflamation of SAH

Study Overview
=================
Brief Summary
-----------------
The investigators are planning that can these markers be used a predictive marker at SAH and for this aim we will study both patiens' blood sample and their CT image.

Detailed Description
-----------------
An ideal marker which could be used clinically should meet numerous criteria, such as high sensitivity or the possibility of easy and quick assessment of its concentration in blood or blood plasma.The Fisher's scale presents an alternative for evaluating patients with subarachnoid hemorrhage . The investigator are going to evaluate both plasma markers and fishers scale at SAH.

Official Title
-----------------
Comparasion of Bio-markers and Neuroimaging Changes Caused by Neuroenflamation After the Aneurysmal Subarachnoid Hemorrhage

Conditions
-----------------
Subarachnoid Hemorrhage, Aneurysmal

Intervention / Treatment
-----------------
* Diagnostic Test: Bezmialem VAkif Unv. Ethical board


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Ruptured Subarachnoid Aneursym Exclusion Criteria: without aneursymal sah Patient's positive for rheumatoid factor and anti-CCP or with chronic inflammatory diseases (such as ankylosing spondylitis or rheumatoid arthritis), systemic diseases (such as hypercholesterolemia, hypertension, diabetes mellitus, myocardial infarction, stroke, peripheral artery disease), active infection, a history of term medication, trauma to the hip and smoking were excluded from the study.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sur1/ Trpm 4 acitivities at SAH<br>only after collecting sample, | Diagnostic Test: Bezmialem VAkif Unv. Ethical board<br>* If ıs any trials not convenient to Helsinki Agrement about Human research rules<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnostic marker identification | Evaluation of the concentration levels of enflamation markers relation with Sur1 TRPM+ molecules, together with the values of global tests of coagulation system, may serve as a helpful SAH diagnostic marker. | 24 months |
Risk Assessment and Treat Compliance in Hypertension Education Trial

Study Overview
=================
Brief Summary
-----------------
The RATCHET study assesses if patient knowledge of estimated cardiovascular risk at current and recommended target blood pressure levels improves compliance in the management of hypertension.

Official Title
-----------------
Evaluation of the Effect of Cardiovascular Risk Assessment in Treatment Compliance in Hypertension

Conditions
-----------------
Hypertension, Dyslipidemia

Intervention / Treatment
-----------------
* Behavioral: Knowledge of Cardiovascular Risk Assessment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Essential hypertension (new diagnosis or established diagnosis) meeting criteria for pharmacologic therapy as defined by current guidelines Exclusion Criteria: Lack of written informed consent Previous myocardial infarction Previous stroke Congestive heart failure Stage 3 or greater chronic kidney disease Pregnancy Usage of medication bubble/blister package

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 84 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: B<br>Standard Care | |
| Experimental: A<br>Risk Assessment plus standard care | Behavioral: Knowledge of Cardiovascular Risk Assessment<br>* Knowledge of Cardiovascular Risk Assessment and risk reduction at target BP, reviewed every 3-6 months.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Medication Compliance |  | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient perception of cardiovascular risk |  | 1 year | 
| Pilot Feasibility Study |  | 1 year | 
| Blood Pressure |  | 1 year | 
| Cholesterol Level |  | 1 year | 
| Framingham Risk Score (stroke and coronary artery disease) |  | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
hypertension, compliance
Intraoperative Laxity Assessment of ACL Reconstruction, ACL Revision and MAT

Study Overview
=================
Brief Summary
-----------------
Intraoperative knee laxity evaluation of patiente undergoing ACL reconstruction, ACL revision, MAT

Detailed Description
-----------------
The study aims to include all thise patients who will undergo anterior cruciate ligament reconstruction, anterior cruciate ligament revision or meniscus transplantation. These patients will undergo an intraoperative kinematic evaluation (pre- and post-ligament reconstruction / meniscal transplantation). There is no follow-up because all the data necessary to carry out the study are obtained during the operating session. In particular, the pre- and post-intervention values (acquired intraoperatively) will be compared using both the surgical navigator and the KiRA system in order to evaluate the effect of the surgical procedure on the value of both static and dynamic laxity of the knee joint. Moreover, limited to the data acquired with the KiRA system, a comparison will be also made with the controlateral limb.

Official Title
-----------------
Intraoperative Laxity Evaluation of Anterior Cruciate Ligament Reconstruction, Anterior Cruciate Ligament Revision and Meniscus Transplantation

Conditions
-----------------
Intraoperative Musculoskeletal Injury

Intervention / Treatment
-----------------
* Procedure: ligament reconstruction and meniscus transplantation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients who have provided written informed written consent Patients aged 14 to 65 Patients undergoing reconstructive surgery of the anterior cruciate ligament or revision of anterior cruciate ligament surgery or meniscus transplantation. Patients unable to understand and want patients who have not signed informed consent Exclusion Criteria: Patients unable to understand and to want Patients who have not signed informed consent

Ages Eligible for Study
-----------------
Minimum Age: 14 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: ligament reconstruction and meniscus transplantation|ACL reconstruction ACL revision MAT|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Laxity Evaluation | Laxity Evaluation will be performed using the intraoperative navigation system | intraoperative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dynamic Laxity Evaluation | Laxity Evaluation will be performed using the KiRA device | intraoperative | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
ACL, MAT, REVISION, LAXITY