Antioxidant and Anti-inflammatory Effects of Yogurt Enriched With Polyphenols

Study Overview
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Brief Summary
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The purpose of this study is to investigate the possible antioxidant and anti-inflammatory effects of yogurt enriched with polyphenols after 2-week consumption by healthy individuals.

Detailed Description
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Eighteen healthy adult volunteers of both sexes consumed yogurt (400g per day) enriched with polyphenols (10mg/100g yogurt) or yogurt (400g per day) not enriched with polyphenols for two weeks in a double-blind, crossover, randomized manner.There was a washout period of at least 10 days. Physiological data and blood samples were collected before and after consumption of each yogurt.

Official Title
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Investigation of the Antioxidant and Anti-inflammatory Effects of Yogurt Enriched With Polyphenols

Conditions
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Oxidative Stress, Inflammation

Intervention / Treatment
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* Other: Yogurt enriched with polyphenols
* Other: Yogurt not enriched with polyphenols


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy individuals Non-smokers Exclusion Criteria: Current use of dietary supplements or drugs Metabolic disease Lactose intolerance Pregnant, pregnancy intention or breast feeding

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Yogurt enriched with polyphenols<br>Two yogurts (400g) enriched with polyphenols (10mg/100g yogurt) per day, for two weeks. | Other: Yogurt enriched with polyphenols<br>* Yogurt enriched with polyphenols extracted from grape seeds<br>|
| Placebo Comparator: Yogurt not enriched with polyphenols<br>Two yogurts (400g) not enriched with polyphenols per day, for two weeks. | Other: Yogurt not enriched with polyphenols<br>* Yogurt not enriched with polyphenols<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Antioxidant effects | Indices of blood antioxidant status | Two weeks | 
| Anti-inflammatory effects | Indices of inflammation in blood | Two weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body composition | Body fat percentage | Two weeks | 
| Blood pressure | Blood pressure at rest | Two weeks | 
| Hydration | Urine specific gravity | Two weeks | 
| Resting heart rate | Resting heart rate | Two weeks | 
| Blood glucose levels |  | Two weeks | 
| Triglyceride levels |  | Two weeks | 
| Total cholesterol levels |  | Two weeks | 
| High Density Lipoprotein cholesterol levels |  | Two weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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antioxidant, oxidative stress, inflammation, polyphenols, yogurt