Physiologic Effects of Sleep Restriction

Study Overview
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Brief Summary
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Evidence suggests a relationship between sleep deprivation and cardiovascular disease. The investigators wish to determine whether 9 nights of modest sleep restriction results in activation of cardiovascular disease mechanisms, thus potentially increasing the risk of cardiovascular disease. The investigators hypothesize that sleep restriction will result in elevated blood pressure, inflammation, and neurocognitive deficits.

Detailed Description
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Evidence suggests a relationship between sleep deprivation and cardiovascular disease. Voluntary sleep restriction is common, with 28% of the US adult population reports getting 6 or fewer hours of sleep per night, and those who do are 24% more likely to have cardiovascular disease and have twice the risk of hypertension. Insufficient sleep may conceivably be one of the most common, and most preventable, cardiovascular risk factors. The investigators wish to determine whether 9 nights of modest sleep restriction results in activation of cardiovascular disease mechanisms, thus potentially increasing the risk of cardiovascular disease. The investigators will combine our cardiovascular studies with state-of-the art sleep monitoring and neurocognitive tests to provide unambiguous data on the physiologic effects of sleep restriction. Together, the investigators findings will help explain whether the reduced sleep duration in the general population may be contributing to the current epidemic of cardiovascular disease, and suggest strategies to reduce this risk.

Official Title
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Physiologic Effects of Sleep Restriction

Conditions
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Sleep Deprivation

Intervention / Treatment
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* Behavioral: sleep restriction


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18-40 years No chronic medical conditions other than seasonal or environmental allergies On no prescription medications other than second generation antihistamines (Cetirizine, Fexofenadine, Desloratadine, Loratadine, etc), oral contraceptive pills, or intrauterine devices. BMI 18.5-35 kg/m2 Both normotensive and prehypertensive people are eligible and will be studied Not a current smoker or tobacco user Not pregnant or breast feeding and not intending to become pregnant or breast feed Exclusion Criteria: The investigators will exclude subjects who have any medical or psychiatric disorders History of anxiety or depression, and those taking any medications other than non-sedating antihistamines or oral contraceptives. Those found to have depression on a depression screening tool (BDI-II) will be excluded. Current smokers will be excluded. All female subjects will undergoing a screening pregnancy test and excluded if positive. Subjects found to have significant sleep disorders will be excluded.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: sleep restriction<br>restricted sleep during the experimental period | Behavioral: sleep restriction<br>* restricted sleep<br>|
| No Intervention: normal sleep<br>normal sleep during the experimental period | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in blood pressure | Change in mean arterial blood pressure over 24 hours, measured during acclimation, experimental, and recovery timepoints over the study period. | throughout 16 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in catecholamines | Change in catecholamines, measured during acclimation, experimental, and recovery | throughout 16 days | 
| Change in endothelial function | Change in endothelial function, measured during acclimation, experimental, and recovery timepoints. | throughout 16 days | 
| Change in baroreflex sensitivity | Change in baroreflex sensitivity, measured during acclimation, experimental, and recovery | throughout 16 days | 
| Change in arterial stiffness | Change in arterial stiffness, measured during acclimation, experimental, and recovery timepoints. | throughout 16 days | 
| Change in electrocardiographic characteristics | Change in electrocardiographic characteristics, measured during acclimation, experimental, and recovery timepoints. | throughout 16 days | 
| Change in markers of inflammation | Change in markers of inflammation, measured during acclimation, experimental, and recovery timepoints. | throughout 16 days | 
| Change in fat tissue characteristics | Change in fat tissue characteristics, determined by analysis of a fat biopsy sample. | throughout 16 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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sleep deprivation, sleep restriction