Peripartum Mental Health Cohort Study in Guangzhou

Study Overview
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Brief Summary
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The purpose of this study is to determine the incidence,development trajectory and risk factors of the main peripartum mental health problems as well as explore its adverse outcomes.

Detailed Description
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Peripartum mental health problems (such as anxiety and depression), affecting more than 20% of mothers, is one of the most common complications around childbirth and gradually have become global public health issues. However, little is known about the course of peripartum mental health problems and possible fluctuations, as well as related risk factors among Chinese women. In addition, there are no effective prediction and preventive strategies for postpartum depression. The Peripartum Mental Health Cohort Study in Guangzhou will collect the epidemiological, clinical information and biological specimens across pregnancy and childbirth to establish trajectory of peripartum mental health and identify the factors influencing the fluctuations and build a comprehensive prediction model of postpartum depression, as well as explore its adverse outcomes. This study would help to determine the timing of screening and target interventions to improve women's and their offspring's health.

Official Title
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Peripartum Mental Health Cohort Study in Guangzhou

Conditions
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Depression, Anxiety

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Pregnant women with <20 weeks of gestation Pregnant women intended to eventually deliver in Guangzhou Women and Children's Medical Center Permanent residents or families intended to remain in Guangzhou with their child for more than 3 years Exclusion Criteria: Combined with heart disease, hypertension, diabetes or hyperthyroidism Taking anti-depressants and other treatments for depression Participants was in infection status when the biological samples were collected
Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of prevalence of maternal prenatal depression | Using Self-rating Depression Scale (SDS) to assess maternal depressive symptoms during pregnancy. SDS scores ≥53 is defined as prenatal depressive symptoms. | before 20th gestational week, after 33th gestational week and prior to delivery | 
| Change of prevalence of maternal postpartum depression in the first year after delivery | Using Edinburgh Postnatal Depression Scale (EPDS) to assess postpartum depressive symptoms. EPDS scores ≥13 is defined as postpartum depressive symptoms. | 6 weeks, 6 months and 1 year after delivery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of prevalence of maternal anxiety during pregnancy | Using Self-rating Anxiety Scale (SAS) to assess maternal anxiety during pregnancy. SAS scores ≥50 is defined as anxiety. | before 20th gestational week, after 33th gestational week and prior to delivery | 
| Level of maternal cortisol during pregnancy | Using women's blood samples to test the concentration of cortisol. | During period of 2-3 trimesters of pregnancy | 
| Levels of maternal inflammatory factors during pregnancy | Using women's blood samples to test the concentration of inflammatory factors, including CRP, IL-6, TNF-α, etc. | During period of 2-3 trimesters of pregnancy | 
| Prevalence of preterm birth, small for gestational age, low birth weight | Obtained from electronic medical records. | At delivery | 
| Child's neurodevelopment at early childhood | Assessed by using the Gesell Developmental Schedules, which includes adaptive, gross motor, fine motor, language, and social function domains. Higher score in each domain is considered a better outcome, while no more than 85 is defined as suspected development delay. | At child's age of 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Peripartum, Mental health, Risk factors, Pregnancy outcome, Cohort