Orexin-A Levels in Insomnia Patients

Study Overview
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Brief Summary
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In the pathophysiology of insomnia, the increase of the orexin-A (OXA) peptide released from orexin neurons in the lateral hypothalamus plays an important role. Orexins takes part at the emergence of anesthesia. In the literature, investigators could not attain any studies about the arousal of insomnia patients from anesthesia. In this study, the effect of this peptide on the emergence process from anesthesia was investigated by comparing plasma OXA levels before and after anesthesia in insomnia patients.

Detailed Description
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ASA (American Society of Anesthesiologists) I-II patients aged 18-65 years who underwent elective laparoscopic cholecystectomy were included in the study. Patients were evaluated with the Jenkins Sleep Disorders scale and Epworth Sleepiness scale during preoperative examination and were divided into insomnia and control groups. Blood samples were obtained for OXA and glucose levels at anesthesia induction, 5 minutes after extubation and 30 minutes after extubation. The times from stopping anesthesia to eyes opening and extubation and end-tidal sevoflurane concentrations at these time points were recorded.

Official Title
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Comparison of Plasma Orexin-A Levels and Awakening Time From Anesthesia in Patients With and Without Insomnia Who Had Laparoscopic Cholecystectomy Under General Anesthesia

Conditions
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Insomnia, Anesthesia

Intervention / Treatment
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* Diagnostic Test: Jenkins Sleep Disorders scale and Epworth Sleepiness scale


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: male patients undergo elective laparoscopic cholecystectomy under general anesthesia Between 18-65 age ASA I-II Exclusion Criteria: ASA≥III Patients with obstructive sleep apnea syndrome Bleeding over 500 ml Allergic to anesthetic agents Patients with a BMI > 30 kg/m2

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| insomnia patients<br>Jenkins Sleep Disorders scale skor >1 and Epworth Sleepiness scale skor >9 | Diagnostic Test: Jenkins Sleep Disorders scale and Epworth Sleepiness scale<br>* Jenkins Sleep Disorders scale and Epworth Sleepiness scale<br>|
| noninsomniacs<br>Jenkins Sleep Disorders scale skor <2 and Epworth Sleepiness scale skor <10 | Diagnostic Test: Jenkins Sleep Disorders scale and Epworth Sleepiness scale<br>* Jenkins Sleep Disorders scale and Epworth Sleepiness scale<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Orexin-A Levels | plasma OXA levels anesthesia induction and after anesthesia in insomnia patients | at anesthesia induction, 5 minutes after extubation and 30 minutes after extubation | 
| Orexin-A Levels | plasma OXA levels anesthesia induction and after anesthesia in control group | at anesthesia induction, 5 minutes after extubation and 30 minutes after extubation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| recovery time from general anesthesia | The relationship between plasma OXA levels and recovery times from anesthesia in insomnia patients | time of eyes opening and time of extubation |