Impact of Genetic Polymorphisms on Dental Implant Loss

Study Overview
=================
Brief Summary
-----------------
Patients that may participate in this case-control study underwent dental implant surgery in the University Hospital in Ghent in 2004-2007. According to one of our recent papers based on this patient group, 34/461 patients lost one or more implants. The goal is to invite these 34 patients, to update the anamnesis, to perform a brief clinical oral examination and to have a blood sample. The latter is necessary to identify relevant genetic polymorphisms of the patient that are associated with implant loss. Among the remaining patients that did not lose implants, another 34 'controls' will be invited for the same examinations.

Official Title
-----------------
A Case-control Study on the Impact of Genetic Polymorphisms on Dental Implant Loss.

Conditions
-----------------
Patients Treated by Means of 1 or More Dental Implants

Intervention / Treatment
-----------------
* Other: anamnesis
* Procedure: oral examination
* Procedure: Blood sample


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Dental implant surgery in the University Hospital in Ghent in 2004-2007. Case: dental implant loss Control: no dental implant loss Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: CONTROL: no dental implants lost<br>Group of patients who received an implant during a dental implant surgery in the University Hospital in Ghent in 2004-2007, who did not lose their implants. | Other: anamnesis<br>* To update the anamnesis.<br>Procedure: oral examination<br>* A brief clinical oral examination will be performed.<br>Procedure: Blood sample<br>* A blood sample will be taken to identify relevant genetic polymorphisms.<br>|
| Experimental: CASE: patients lost one or more implants<br>Group of patients who received an implant during a dental implant surgery in the University Hospital in Ghent in 2004-2007, but who lost one or more implants. | Other: anamnesis<br>* To update the anamnesis.<br>Procedure: oral examination<br>* A brief clinical oral examination will be performed.<br>Procedure: Blood sample<br>* A blood sample will be taken to identify relevant genetic polymorphisms.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| genetic polymorphisms associated with implant loss | Identification of genetic polymorphisms that are associated with implant loss. It concerns only one evaluation (1 blood sample). | after 3 to 6 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
dental implant