Incidence and Predictors of Post-TIPS Heart Failure in Patients With Cirrhosis

Study Overview
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Brief Summary
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The purpose of this study is to conduct a prospective trial to investigate the incidence of heart failure in cirrhosis patients undergoing transjugular intrahepatic portosystemic shunt ,and to analyze the the predictors and modififications of cardiac function.

Detailed Description
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Hyperdynamic circulation is a common Phenomenon in cirrhosis due to systemic and splanchnic vasodilatation, which may result cardic dysfunction and abnormal structure ,called cirrhotic cardiomyopathy(CCM). Transjugular intrahepatic portosystemic shunt (TIPS), as a effective technique to alleviates portal hypertension in cirrhotic patients, often be used to treat with refractory ascites and variceal bleeding which endoscopy and drug therapy are ineffective. However, owing to the increased shunting of blood from the splanchnic vascular bed into the central vascular bed, TIPS further exacerbates the hyperdynamic circulatory state, which may lead to heart failure.yet there are no convincing research to study the incidence of heart failure in cirrhosis after transjugular intrahepatic portosystemic shunt. The purpose of this study is to conduct a prospective trial to investigate the incidence of heart failure in cirrhotic patients undergoing transjugular intrahepatic portosystemic shunt ,and to analyze the the predictors and modififications of cardiac function.

Official Title
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Incidence and Predictors of Post-TIPS (Transjugular Intrahepatic Portosystemic Shunt (TIPS) Heart Failure in Patients With Cirrhosis

Conditions
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Liver Cirrhosis, Transjugular Intrahepatic Portosystemic Shunt (TIPS), Heart Failure

Intervention / Treatment
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* Procedure: TIPS


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Cirrhosis TIPS is placed successfully Agree to participate in the trial Exclusion Criteria: Non-cirrhotic portal hypertension Previous TIPS or surgical shunt Medium to severe pulmonary hypertension Heart failure End-stage renal disease requiring hemodialysis Respiratory failure Malignancies with a life expectancy of less than 6 months

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with cirrhosis who underwent TIPS<br>Patients with cirrhosis who underwent TIPS due to complications of portal hypertension were inclueded for observation. | Procedure: TIPS<br>* TIPS: Established distributary channel between the portal vein and hepatic vein via the jugular vein, portal vein blood directly shunts into the systemic circulation to reduce portal vein pressure to effectively prevent bleeding and refractory ascites.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of heart failue | Heart failue assessed by2021 ESC Guidelines | up to 36 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Predictors of heart Failure | Heart failue assessed by2021 ESC Guidelines | up to 36 months | 
| mortality | Telephone follow-up was performed to collect relevant information | up to 36 months | 
| Modififications of cardiac function | Echocardiography was to evaluate cardic function | up to 36 months |