Metabolomic Profile of Patients Undergoing Myocardial Perfusion SPECT

Study Overview
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Brief Summary
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The aim of this study is to analyze metabolomic pattern of patients after cardiac stress in order to detect differences based on the type of stress (physical or pharmacological with adenosine agonists) and result of test (positive or negative for ischemia) and to indentify biochemical markers with prognostic value. Clinical data of enrolled patients regarding demographics, cardiovascular risk factors, pretest probability and previous cardiovascular disease will be recorded. Follow up will be at one, three and five years and will be performed by clinical recordings or phone call when necessary. Blood samples of patients undergoing myocardial perfusion SPECT (Single Photon Emission Computed Tomography) are taken before, immediately after stress and 2h after stress. Serum samples will be analyzed by nuclear magnetic resonance in order to know metabolomic profile.

Detailed Description
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The aim of this study is to analyze metabolomic pattern of patients after cardiac stress in order to detect differences based on the type of stress (physical or pharmacological with adenosine agonists) and result of test (positive or negative for ischemia) and to indentify biochemical markers with prognostic value. Clinical data of enrolled patients regarding demographics, cardiovascular risk factors, pretest probability and previous cardiovascular disease will be recorded. Follow up will be at one, three and five years and will be performed by clinical recordings or phone call when necessary. Blood samples of patients undergoing myocardial perfusion SPECT are taken before, immediately after stress and 2h after stress. Serum samples will be analyzed by nuclear magnetic resonance in order to know metabolomic profile.

Official Title
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Metabolomic Profile of Patients Undergoing Myocardial Perfusion SPECT

Conditions
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Ischemic Heart Disease

Intervention / Treatment
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* Other: Non intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients men or women ≥ 18 years of age Patients with prescription of cardiac perfusion SPECT Exclusion Criteria: Patients with loss of consciousness or confuse, not able to read the information and to sign the writting consent Pregnant women Patients with dobutamine indications in the stress protocol

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with Physical Cardiac Stress<br>Patients with Physical Cardiac Stress | Other: Non intervention<br> <br> |
| Patients with Physical and Pharmacological Cardiac Stress<br>Patients with Physical and Pharmacological Cardiac Stress with adenosine agonist | Other: Non intervention<br> <br> |
| Patients with Pharmacological Cardiac Stress<br>Patients with Pharmacological Cardiac Stress with adenosine agonist | Other: Non intervention<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Result of myocardial perfusion SPECT: positive or negative for angina, ischemia or perfusion defect. |  | 2 days | 
| Metabolomic profile on NMR (Nuclear Magnetic Resonance ) analysis of serum sample | Once all samples analyzed, in order to identify of specific patterns associated to any group (type of test or result of test). | 6 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Combined end point: Cardiovascular death, Myocardial infarction, Coronary revascularization. |  | 1 year | 
| Combined end point: Cardiovascular death, Myocardial infarction, Coronary revascularization. |  | 3 years | 
| Combined end point: Cardiovascular death, Myocardial infarction, Coronary revascularization. |  | 5 years | 
| Angina treatment initiation |  | 1 year | 
| Angina treatment initiation |  | 3 years | 
| Angina treatment initiation |  | 5 years | 
| Metabolomic profile on NMR analysis of serum sample |  | 1 year | 
| Metabolomic profile on NMR analysis of serum sample |  | 3 years | 
| Metabolomic profile on NMR analysis of serum sample |  | 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Coronary artery disease, Cardiac perfusion SPECT, Metabolomics