Bevacizumab and Interleukin-2 in Treating Patients With Metastatic Kidney Cancer

Study Overview
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Brief Summary
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RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Interleukin-2 may stimulate the white blood cells to kill tumor cells. Giving bevacizumab together with interleukin-2 may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving bevacizumab together with interleukin-2 works in treating patients with metastatic kidney cancer.

Detailed Description
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OBJECTIVES: Primary Estimate the response, progression-free survival, and overall survival of patients with metastatic renal cell carcinoma (RCC) treated with bevacizumab and high-dose interleukin-2 (IL-2). Secondary Compare the response and survival of patients with metastatic RCC treated with bevacizumab and high-dose IL-2 with the historical data of patients treated with high-dose IL-2 alone. Compare the toxicity of bevacizumab and high-dose IL-2 in patients with metastatic RCC with the historical data of patients treated with high-dose IL-2 alone, in terms of number of doses of IL-2 administered during the first course of therapy, toxicity after the scheduled ninth dose of IL-2, and frequency of grade III and IV or unexpected or rare toxicities. Compare the time to disease progression in patients with metastatic RCC treated with bevacizumab and high-dose IL-2 with the historical data of patients treated with high-dose IL-2 alone. Evaluate the pharmacokinetics and pharmacodynamics of bevacizumab and high-dose IL-2 during course 1. Correlate serum vascular endothelial growth factor (VEGF) levels, DC function, TCR zeta chain expression, and arginase or arginine levels with toxicity, response, and survival of patients treated with this regimen. Evaluate the utility of known prognostic criteria for RCC patients on clinical outcome. OUTLINE: This is a multicenter study. Patients are stratified according to prognosis (good vs intermediate vs poor). Patients receive bevacizumab IV over 30-90 minutes on days -13, 1, 15, 29, 43, 57, and 71 during course 1 and on days 1, 15, 29, 43, 57, and 71 during courses 2 and 3. Patients also receive high-dose interleukin-2 every 8 hours on days 1-5 and 15-19. Treatment repeats every 84 days for up to 3 courses in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed every 3 months for 2 years and then every 6 months thereafter. PROJECTED ACCRUAL: A total of 65 patients will be accrued for this study.

Official Title
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A Phase II Study of Bevacizumab and Aldesleukin in Patients With Metastatic Renal Cell Carcinoma (RCC): A Cytokine Working Group (CWG) Study

Conditions
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Kidney Cancer

Intervention / Treatment
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* Biological: aldesleukin
* Biological: bevacizumab


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Histologically confirmed metastatic renal cell carcinoma (RCC) with predominantly clear cell histology Measurable disease No history of tumor-related hemorrhage No history of CNS or brain metastases PATIENT CHARACTERISTICS: Karnofsky performance status ≥ 80% Absolute neutrophil count ≥ 1,000/mm^3 Platelet count ≥ 100,000/mm^3 Hemoglobin ≥ 9 g/dL (transfusion or recombinant erythropoietin growth factors allowed) AST ≤ 2 times upper limit of normal (ULN) (5 times ULN if due to liver metastases) Serum total bilirubin ≤ 2 times ULN (except for patients with Gilbert's disease) Serum creatinine ≤ 1.5 mg/dL OR creatinine clearance ≥ 60 mL/min FEV_1 ≥ 2.0 L or ≥ 75% of predicted Pulmonary function testing required for patients over age 50 or with significant pulmonary or smoking history No history of cerebrovascular accident or transient ischemic attacks No evidence of any of the following cardiac conditions*: Congestive heart failure Symptoms of coronary artery disease Myocardial infarction < 6 months prior to study entry Serious cardiac arrhythmias Unstable angina NOTE: *Patients > 40 years old or who have had a previous myocardial infarction > 6 months prior to study entry are required to have a negative or low probability cardiac stress test for cardiac ischemia Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception No other malignancy within the past 5 years except nonmelanoma skin cancer or noninvasive cancer, such as cervical carcinoma in situ, superficial bladder cancer without local recurrence, or breast cancer in situ Patients with a history of another invasive malignancy must be in complete remission for ≥ 5 years No positive serology for HIV, hepatitis B, or hepatitis C No significant co-morbid illness, such as uncontrolled diabetes or active infection, that would preclude study treatment No history of inflammatory bowel disease or other serious autoimmune disease Thyroiditis or rheumatoid arthritis allowed No uncontrolled hypertension (i.e., blood pressure > 150/100 mm Hg) Proteinuria ≤ 3+ by dipstick OR proteinuria < 2 gm by 24-hour urine collection Urine protein:creatinine ration < 1.0 No abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to study entry No significant traumatic injury within the past 28 days No serious, nonhealing wound, ulcer, or bone fracture No active bleeding No history of other serious hemorrhage, bleeding diathesis, or underlying coagulopathy No history of deep venous thrombosis, clinically significant peripheral vascular disease, or other thrombotic event PRIOR CONCURRENT THERAPY: No organ allografts At least 4 weeks since prior radiotherapy or surgery and recovered No prior systemic therapy for metastatic RCC No prior bevacizumab or interleukin-2 At least 2 weeks since prior steroids No major surgery or open biopsy within the past 28 days No minor surgical procedures, fine needle aspirations, or core biopsies within the past 7 days, except central venous catheter placement No concurrent major surgery No concurrent corticosteroids or other immunosuppressants

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: aldesleukin|nan|
|Biological: bevacizumab|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Response |  |  | 
| Progression-free and overall survival |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of response and survival with historical data |  |  | 
| Toxicity |  |  | 
| Time to disease progression |  |  | 
| Pharmacokinetics and pharmacodynamics |  |  | 
| Correlation of serum VEGF levels, DC function, TCR zeta chain expression, and arginase or arginine levels with toxicity, response, and survival |  |  | 
| Utility of known prognostic criteria |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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stage IV renal cell cancer, recurrent renal cell cancer, clear cell renal cell carcinoma