Preserving Left Colonic Artery During Radical Resection of Rectal Cancer

Study Overview
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Brief Summary
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To evaluate the feasibility and clinical significance of preserving left colonic artery in rectal cancer surgery.The investigators will focus on the effect of preserving left colonic artery during radical resection of rectal cancer on anastomotic leakage and oncology efficacy.

Detailed Description
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The investigators performed three-dimensional (3D) reconstruction to investigate the vascular anatomy, including the inferior mesenteric artery (IMA) and left colic artery (LCA),to help make pre-operative strategies of rectal cancer surgery.The investigators will preserving the left colonic artery during rectal cancer surgery and evaluate its feasibility and clinical significance.The investigators will focus on the effect of preserving left colonic artery during radical resection of rectal cancer on anastomotic leakage and oncology efficacy.

Official Title
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A Clinical Cohort Study on the Effect of Preserving Left Colonic Artery During Radical Resection of Rectal Cancer on Anastomotic Leakage and Oncology Efficacy

Conditions
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Postoperative Complications, Proteinosis

Intervention / Treatment
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* Procedure: Preserve the left colonic artery
* Procedure: The left colonic artery is not preserved


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Pathological biopsy confirmed adenocarcinoma of the rectum； Preoperative assessment of tolerance to surgery without major organ dysfunction； Patients must be able to understand and voluntarily sign written informed consent； The surgical method is laparoscopic or robotic anterior rectal cancer resection. Exclusion Criteria: The patient cannot tolerate the operation； Refusal to sign informed consent； Patients with distant metastasis of rectal cancer； The surgical method was changed to miles or Hartman; Unable to complete the follow - up

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Preserve the left colonic artery<br>Preservation of left colonic artery in rectal cancer surgery. | Procedure: Preserve the left colonic artery<br>* Preservation of left colonic artery in rectal cancer surgery.<br>|
| The left colonic artery is not preserved<br>The left colonic artery was dissected in rectal cancer surgery | Procedure: The left colonic artery is not preserved<br>* The left colonic artery was dissected in rectal cancer surgery.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The incidence of postoperative anastomotic leakage was compared between the two groups. | The incidence of anastomotic leakage within 30 days after surgery was compared between the intervention group and the control group. | Within 30 days after surgery | 
| The distant metastasis rates of rectal cancer between the two groups were compared. | The incidence of distant metastasis rectal cancer within two years after surgery was compared between the intervention group and the control group. | Two years after surgery | 
| The local recurrence rates of rectal cancer between the two groups were compared. | The incidence of local recurrence rectal cancer within two years after surgery was compared between the intervention group and the control group. | Two years after surgery | 
| The five-year survival rates of rectal cancer between the two groups were compared. | The 5-year survival rates of rectal cancer in the intervention group and the control group were compared. | Five years after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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rectal cancer, Postoperative Complications, Preserve the left colonic artery