Bortezomib and Romidepsin in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Study Overview
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Brief Summary
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This phase I trial studies the side effects and best dose of giving bortezomib and romidepsin together in treating patients with chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), indolent B-cell lymphoma, peripheral T-cell lymphoma (PTCL) or cutaneous T-cell lymphoma (CTCL). Bortezomib and romidepsin may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.

Detailed Description
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OBJECTIVES: Primary Determine the maximum tolerated dose (MTD) for the combination of bortezomib and romidepsin administered weekly x 3 every (q) 4wk in patients with CLL/SLL, indolent B-cell lymphoma, PTCL or cutaneous T-cell lymphoma (CTCL). Secondary Determine safety and tolerance and describe the toxicities of the combination. Demonstrate adequate methods for the assessment of pharmacodynamic responses of CLL cells to the combination with respect to effects on NF-kappa B (nuclear RelA and processing of p52 as a marker of p100 processing), expression of the NF-kappa B-dependent proteins XIAP and Bcl-xL, and Bim, and document pharmacodynamic responses observed in the course of this study * Document the pharmacodynamic responses associated with this regimen in these patients. Document the anticancer activity of this regimen in these patients. OUTLINE: Patients receive bortezomib IV over 3-5 seconds and romidepsin IV over 4 hours on days 1, 8, and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. Blood samples from patients with chronic lymphocytic leukemia are collected at baseline and after day 1 of course 1 of study treatment for pharmacodynamic and correlative laboratory studies.

Official Title
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Phase I Study of Bortezomib and Romidepsin in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Indolent B-Cell Lymphoma, Peripheral T-Cell Lymphoma or Cutaneous T-Cell Lymphoma

Conditions
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Leukemia, Lymphoma

Intervention / Treatment
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* Drug: Bortezomib
* Drug: Romidepsin


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: * Diagnosis of 1 of the following: CLL or SLL, relapsed or refractory Indolent B-cell lymphoma, relapsed or refractory: Follicle center lymphoma, follicular or diffuse Marginal zone B-cell lymphoma (splenic, nodal, extranodal [this includes mucosa associated lymphoid tissue (MALT)]) Lymphoplasmacytic lymphoma PTCL, relapsed or refractory: Anaplastic large cell lymphoma, anaplastic lymphoma kinase (ALK)-positive Anaplastic large cell lymphoma, ALK-negative Angioimmunoblastic T-cell lymphoma Enteropathy-associated T-cell lymphoma Extranodal natural killer (NK)/T-cell lymphoma, nasal type Hepatosplenic T-cell lymphoma PTCL, not otherwise specified (NOS) Subcutaneous panniculitis-like T-cell lymphoma CTCL: * CTCL with subtypes of mycosis fungoides Stage IB or higher, Sézary syndrome, or primary cutaneous anaplastic large cell lymphoma who have failed a previous systemic treatment, as per the following: Stage IA plaque, IB, or IIA: At least 4 prior conventional and/or experimental regimens (topical or systemic, including psoralen-ultraviolet light [PUVA] and systemic corticosteroids) Stage IIB, III, or IV: At least 1 prior systemic regimen (systemic corticosteroids alone or PUVA alone do not count as systemic regimens for this purpose) NOTE: Repeated use of the same regimen is considered 1 regimen Prior allogeneic stem cell transplant is allowed provided that all of the following conditions are met: >= 6 months have elapsed since allogeneic transplant No Graft vs. Host Disease (GVHD) is present Not currently on immunosuppressive therapy No prior or concurrent CNS malignancy PATIENT CHARACTERISTICS: ECOG performance status 0-1 ANC > 1,500/mm^3 Platelet count > 75,000/mm^3 Hemoglobin > 7.5 g/dL (transfusion allowed) Serum creatinine ≤ 1.2 mg/dL or actual or calculated creatinine clearance > 60 mL/min AST and ALT ≤ 2.5 times upper limit of normal (ULN) Bilirubin ≤ ULN Serum potassium ≥ 3.5 mEq/L (supplementation allowed) Serum magnesium ≥ 1.7 mEq/L (supplementation allowed) Not pregnant or nursing Negative pregnancy test Fertile patients must use effective non-hormonal contraception Willing and able to comply with protocol requirements No prior severe allergic reactions to bortezomib, boron, mannitol, or romidepsin No progressing toxicity secondary to bortezomib No grade 1 peripheral neuropathy with pain or ≥ grade 2 peripheral neuropathy by NCI-CTCAE criteria (v4.0) within the past 14 days No condition related to ischemic heart disease, heart failure, or the risk of torsades de pointes or sudden cardiac death, including any of the following: History of sustained ventricular tachycardia, ventricular fibrillation, torsades de pointes, or resuscitated cardiac arrest unless currently addressed with an implantable cardiac defibrillator Baseline heart rate > 140 beats per minute Known congenital long QT syndrome QTc interval > 480 milliseconds Type II second-degree atrio-ventricular (AV) block, third-degree AV block, or ventricular rate < 50 beats per minute Myocardial infarction within the past 6 months Patients who have had a myocardial infarction 6-12 months ago are eligible provided they are asymptomatic and have a negative cardiac risk assessment (i.e., treadmill stress test, nuclear medicine stress test, or stress echocardiogram) Angina upon ordinary physical activity Angina only with strenuous, rapid, or prolonged exertion allowed ECG with evidence of cardiac ischemia, as defined by the following: ST depression of ≥ 2 mm, measured from isoelectric line to ST segment T-wave inversion ≥ 4 mm, measured from isoelectric line to peak of T-wave NYHA class II-IV congestive heart failure Known left ventricular ejection fraction < 40% by MUGA scan or < 50% by echocardiogram or MRI Known hypertrophic cardiomegaly or restrictive cardiomyopathy No uncontrolled hypertension, defined as persistent blood pressure ≥ 160/95 mm Hg despite medical management No clinically significant active infection, including known HIV infection or hepatitis B or C No other malignancy within the past 3 years except completely resected basal cell carcinoma or squamous cell carcinoma of the skin, in situ malignancy, or curatively treated low-risk prostate cancer No concurrent medical condition that, in the investigator's opinion, would compromise study treatment or assessment of toxicity PRIOR CONCURRENT THERAPY: See Disease Characteristics At least 3 weeks since prior chemotherapy, radiation therapy or investigational agents. If steroids for cancer control have been used, patients must be off theses agents for at least 1 week before starting treatment. (Maintenance therapy for non-malignant disease with prednisone or steroid equivalent dose less than 10 mg/day is permitted) Prior allogeneic stem cell transplantation allowed provided all of the following conditions are met: Greater than or equal to 6 months have elapsed since allogeneic transplant No Graft vs. Host Disease (GVHD) is present More than 4 weeks since prior bortezomib No concurrent oral hormonal contraceptives No concurrent potent or moderate CYP3A4 inhibitors No concurrent anti-arrhythmic agents No concurrent treatment with any drugs that are generally accepted to having a risk of causing torsades de pointes (class 1 drugs) Class 2 or 3 drugs allowed at the discretion of the investigator No other concurrent systemic therapy for the malignancy Concurrent warfarin (coumadin) allowed

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: bortezomib + romidepsin<br>Bortezomib via a short intravenous infusion (3-5 seconds) followed by romidepsin via a 4 hour intravenous infusion weekly x 3 every 4 weeks. In order to identify appropriate doses, different subjects will be treated with different drug doses and observed for the effects, especially the side effects associated with higher doses. | Drug: Bortezomib<br>* Starting dose: 1.3 mg/sq m<br>* Other names: PS-341;Drug: Romidepsin<br>* Starting dose: 8 mg/sq m<br>* Other names: FK288;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximum tolerated dose | Dose at which no more than 1 dose-limiting toxicity is observed in as many as 6 patients | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pharmacodynamic responses | To explore candidate pharmacodynamic markers for use in subsequent phase II trials. | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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refractory chronic lymphocytic leukemia, stage I chronic lymphocytic leukemia, stage II chronic lymphocytic leukemia, stage III chronic lymphocytic leukemia, stage IV chronic lymphocytic leukemia, recurrent small lymphocytic lymphoma, contiguous stage II small lymphocytic lymphoma, noncontiguous stage II small lymphocytic lymphoma, stage I small lymphocytic lymphoma, stage III small lymphocytic lymphoma, stage IV small lymphocytic lymphoma, adult nasal type extranodal NK/T-cell lymphoma, anaplastic large cell lymphoma, angioimmunoblastic T-cell lymphoma, extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, hepatosplenic T-cell lymphoma, nodal marginal zone B-cell lymphoma, peripheral T-cell lymphoma