Upper Airway Obstruction in Non-obese Patients With Snoring and Obstructive Sleep Apnea

Study Overview
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Brief Summary
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This study aims at :- detecting the prevelance of snoring and OSA in non-obese patients identify their diagnostic profile in order to provide proper management

Detailed Description
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Snoring is the vibration of respiratory structures and the resulting sound due to obstructed air movement during breathing while sleeping. Snoring during sleep may be a sign, or first alarm, of obstructive sleep apnea (OSA). Snoring can cause significant psychological and social problems to sufferers. Multiple studies reveal a positive correlation between loud snoring and risk of heart attack and stroke. Obstructive sleep apnea (OSA) is the commonest type of sleep apnea and is characterized by inturpted snoring, repeated attacks of complete or partial pharyngeal closure during sleep despite the effort to breath resulting in nocturnal hypoxemia, frequent arousals during sleep, and excessive daytime sleepiness (EDS). Obstructive Sleep Apnea is differentiated from Central Sleep Apnea (CSA) which is characterized by changes in the respiratory cycle during sleep but without the effort to breath during the apnea. the episodes of decreased breathing are called hypopnea  and it's definition requires a < 30% drop in flow for 10 seconds or longer associated with < 3% oxygen desaturation , the episodes of breathing cessations are called apneas and defined as a< 90% drop in flow for 10 seconds or longer and associated with < 3% oxygen desaturation or an arousal It is a serious and potentially life threatening disease that is far more common than generally expected. Several risk factors, including obesity, male sex, age, and heritable factors, as well as the supine decubitus position during sleep. have been associated with an increased prevalence of obstructive sleep apnea in the general population. It has become a major health issue all over the world affecting quality of life with an increasing prevalence and associated with high comorbidities such as diabetes mellitus, hypertension, cardiovascular disease, dyslipidemia, malignancies, and overall mortality. Results of different studies indicate that approximately 60-70% of patients with OSA are obese. Snoring and witnessed apnea are more frequent among men but insomnia for example is more frequent among women. The OSA frequency increase with age for the women. The mortality is higher for women The data regarding association of OSA among nonobese patients is rare and needs great effort as fewer studies have reported magnitude of association.

Official Title
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a Study of the Pattern of Upper Airway Obstruction in Non-obese Patients With Snoring and Obstructive Sleep Apnea

Conditions
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Snoring

Intervention / Treatment
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* Device: nasofibroscopy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: older than 18 years patients complaining of snoring and obstructive sleep panea Exclusion Criteria: chronic pulmonary disease ( COPD, Asthma ,IPF) Pregnancy sever cardiovascular disease ( unstable angina , sever arrhythmia , MI) chronic renal failure (CRF) neurological disorders

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: nasofibroscopy|Flexible videorhinolaryngoscope, PAL 11101VP*, 4.2 mm diameter. Using a computerized system including: Light source: Explor ENT (HAL250). The software allowed audio, video recording and retrieval of recorded material.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| compare snoring and obstructive sleep apnea between obese and non obese | by analysing data of muller's manauver and sleep endoscopy between obese and nonobese | baseline |