A Comparative Study of Effects of Berry and Grain Products on Postprandial Glycemic Response in Healthy Subjects

Study Overview
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Brief Summary
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This study aims to determine the 2 hour glycemic responses of two bread products and one dried lingonberry product. The average postprandial response of each product is compared with glycemic response after ingestion of control solution with a similar carbohydrate content (glucose, glucose-fructose) as the provided by the respective test product.

Official Title
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A Clinical, Randomized, Comparative Study of Effects of Berry and Grain Products on Postprandial Glycemic Response in Healthy Subjects

Conditions
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Healthy

Intervention / Treatment
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* Other: Berry product
* Other: Bread product
* Other: Bread product
* Other: Glucose control solution
* Other: Glucose-fructose control solution


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: voluntary given written concent for participation in research healthy man or woman, age between 18 and 65 years regular eating Body Mass Index 18,5 - 29,9 kg/m2 Exclusion Criteria: diabetes gastrointestinal diseases hepatic, kidney, pancreas or thyroid disease or disorder arthritis pregnancy or breast feeding smoking allergy severe diseases blood donation

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Berry product|Sugar infused dried lingonberry|
|Other: Bread product|Brown bread|
|Other: Bread product|Whole grain bread|
|Other: Glucose control solution|Glucose solution with a corresponding amount of carbohydrates as provided by the bread test products|
|Other: Glucose-fructose control solution|Control solution with a similar carbohydrate content as provided by the dried lingonberry test product|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The 2 hours glycemic responses to test products and control solutions | Capillary blood samples are taken before and at 15, 30, 45, 60, 90 and 120 min after starting to eat the test products or control solutions for measurements of plasma glucose concentrations. | 2 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The 2 hours insulinemic responses to dried lingonberry product and corresponding control solution | Capillary blood samples are collected before and at 15, 30, 45, 60, 90 and 120 min after eating the lingonberry test product and glucose-fructose control solution. The serum insulin concentrations are analysed. | 2 hours | 
| The incremental area under glucose curve (IAUC) of bread test products | IAUC (mmol/l x min) is determined using the trapezoidal method for each subject and bread test product and corresponding glucose control solution. | 2 hours | 
| Glycemic index (GI) of bread test products | The GI is calculated as a percentage of the glucose IAUC values of a bread product and a glucose control solution. |  |