Prospective Cohort Study of Intracerebral Hemorrhage

Study Overview
=================
Brief Summary
-----------------
The investigators design a prospective, observational cohort study to provide contemporary information on the prevalence, characteristics, risk stratification，cost-effective ,treatments and prognosis of Chinese hospitalised adult patients with intracerebral hemorrhage.

Detailed Description
-----------------
Intracerebral hemorrhage (ICH) remains a devastating disease with high mortality, yet few therapeutic managements have been proved effective. Large quantities of work needs to be done to fully delineate the prevalence and prognosis of ICH. Hence, the investigators design a prospective, observational cohort study to provide contemporary information on the prevalence, characteristics, risk stratification，cost-effective, treatments and prognosis of Chinese hospitalised adult patients with ICH.

Official Title
-----------------
A Prospective Observational Cohort Study in Chinese Patients With Primary Intracerebral Hemorrhage

Conditions
-----------------
Intracerebral Hemorrhage

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Hospitalized patients over 18 years old of primary intracerebral hemorrhage. Exclusion Criteria: patients of secondary intracerebral hemorrhage，such as hemorrhagic transformation of ischemic stroke, aneurysmal, cavernomas, arterio- venous malformations, central venous thrombosis, trauma-related, or tumor. isolated intraventricular hemorrhage or subarachnoid hemorrhage pregnant patients； surgical evacuation of hematoma； unavailability to get complete blood cell samples and presenting contraindications or refusal to MRI patients cannot be followed up for any reasons. patients death in 24 hours pregnant patients

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Second Affiliated Hospital, School of Medicine, Zhejiang University<br>a prospective cohort of patients of primary intracerebral hemorrhage in Second Affiliated Hospital, School of Medicine, Zhejiang University | |
| Second People's Hospital of Hangzhou City, Zhejiang Province<br>a prospective cohort of patients of primary intracerebral hemorrhage in Second People's Hospital of Hangzhou City, Zhejiang Province | |
| 4th Affiliated Hospital, School of Medicine at Zhejiang University<br>a prospective cohort of patients of primary intracerebral hemorrhage in 4th Affiliated Hospital, School of Medicine at Zhejiang University | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| proportion of patients with a 3-month modified Rankin Scale (mRS) score≤ 3 | mRS 0-6, higher indicate worse outcome | 2-3years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Absolute peripheral hematoma edema(PHE) growth | absolute peripheral hematoma edema growth in CT/MRI measured by picture archiving and communication systems(PACS) system | 2-3years | 
| Relative peripheral hematoma edema(rPHE) | rPHE：absolute PHE divided by hematoma volume in CT/MRI | 2-3years | 
| National institute of health stroke scale（NIHSS score） | NIHSS 0-42, higher indicate worse outcome | 2-3years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
primary intracerebral hemorrhage, hypertension, perihematomal edema, secondary brain injury, remote diffusion-weighted imaging lesions (R-DWILs), immune response, multimodel image, cohort, MRI