Effect of Granisetron on Usage of Sympathomimetics During Caesarean Section

Study Overview
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Brief Summary
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The aim of the present study is to quantify the dose and usage of sympathomimetics used in caesarean section.

Detailed Description
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Recent metaanalysis showed significantly reduced hypotension and bradycardia in patients undergoing caesarean section in spinal anesthesia when 5-hydroxytryptamine 3 receptor antagonists were used prophylactically. Due to this fact in our clinic the standard procedure was changed. All patients for caesarean section receive Granisetron before spinal anesthesia. The aim of the present study is to evaluate the usage and dose of sympathomimetics during spinal anesthesia. Therefore the investigators will evaluate approximately 120 participants who received granisetron and 120 participants who did not receive 5-hydroxytryptamine 3 receptor antagonists.

Official Title
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Effect of Granisetron on Usage of Sympathomimetics During Caesarean Section - a Retrospective Analysis

Conditions
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Hypotension, Cesarean Section Complications

Intervention / Treatment
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* Drug: Granisetron Hydrochloride
* Drug: No Granisetron


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: caesarean section in spinal anesthesia Exclusion Criteria: withdrawal incomplete documentation
Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Granisetron<br>120 Patients prior to changes of intern standards of caesarean section. Before march 2017 no patient undergoing elective caesarean section received Granisetron as a matter of routine. | Drug: No Granisetron<br>* Patients who did not receive Granisetron.<br>|
| With Granisetron<br>120 Patients after changes of intern standards of caesarean section. After march 2017 all patient undergoing elective caesarean section received Granisetron as a matter of routine. | Drug: Granisetron Hydrochloride<br>* Patients received Granisetron.<br>* Other names: 5-hydroxytryptamine 3 receptor antagonist;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sympathomimetics | Type of sympathomimetics during during the operation | 30 minutes starting with induction of spinal anesthesia. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sympathomimetics | Cumulative dose of sympathomimetics during during the operation | 30 minutes starting with induction of spinal anesthesia. | 
| Volume substitution | Type of perioperative infused volume during the operation | 30 minutes starting with induction of spinal anesthesia. | 
| Volume substitution | Cumulative volume of perioperative infused volume during the operation | 30 minutes starting with induction of spinal anesthesia. | 
| Haemotherapy | Type of haemotherapy. | 30 minutes starting with induction of spinal anesthesia. | 
| Haemotherapy | Cumulative volume of haemotherapy. | 30 minutes starting with induction of spinal anesthesia. | 
| Duration until first application of sympathomimetics | Duration until first administration of any kind of sympathomimetics. | 30 minutes starting with induction of spinal anesthesia. | 
| Oxytocin | Duration until first administration of oxytocin. | 30 minutes starting with induction of spinal anesthesia. | 
| Oxytocin | Cumulative dose of Oxytocin. | 30 minutes starting with induction of spinal anesthesia. | 
| Uterotonic agents | Kind of uterotonic agents. | 30 minutes starting with induction of spinal anesthesia. | 
| Uterotonic agents | Cumulative dose of uterotonic agents. | 30 minutes starting with induction of spinal anesthesia. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Serotonin Antagonists, Sympathomimetics