Sparsity-based Magnetic Resonance Imaging of Cardiac Arrhythmias

Study Overview
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Brief Summary
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The primary purpose of this study is to improve the quality of Magnetic Resonance Imaging in patients with heart arrhythmia. Investigators will recruit 105 patients with arrhythmia and 30 control volunteers over 3 years and will use two arrhythmia-tolerant imaging methods for diagnosis.

Detailed Description
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In the proposed research, investigators will extend conventional cardiac magnetic resonance methods to enable the creation of high-quality cine CMR images in the presence of multiple kinds of arrhythmia. Two arrhythmia-tolerant imaging methods will be adopted, which are particularly useful in arrhythmia: 1) 3D imaging, which is useful for many purposes, including road mapping of electrophysiology (EP) procedures, and 2) late gadolinium enhancement (LGE), which is useful for delineating abnormal myocardium, including fibrotic regions that can serve as sources of arrhythmias.

Official Title
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Sparsity-based Magnetic Resonance Imaging of Cardiac Arrhythmias

Conditions
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Cardiac Arrythmias

Intervention / Treatment
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* Other: 3D Imaging
* Other: Late Gadolinium Enhancement (LGE)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria for Arrhythmia Patients: Patients diagnosed with heart arrhythmia scheduled for routine clinical MRI examinations). Patients scheduled for routine clinical MRI examinations who do not have a specific known diagnosis of arrhythmia, but who may be found to have image degradation due to arrhythmia during the CMR examination. Inclusion Criteria for Controls: No history of heart arrhythmia. Exclusion Criteria for Patients and Controls: Hemodynamic instability. Contraindications for MRI examinations (e.g., pacemakers or ferromagnetic vascular clips). History of prior cardiovascular disease or significant risk factors: Diabetes, hypertension, smoking, and hyperlipidemia, etc.

Ages Eligible for Study
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Minimum Age: 10 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Patients with Arrhythmias<br> | Other: 3D Imaging<br>* roadmapping of electrophysiology (EP) procedures<br>Other: Late Gadolinium Enhancement (LGE)<br>* useful for delineating abnormal myocardium, including fibrotic regions that can serve as sources of arrhythmias.<br>|
| Other: Healthy Control<br> | Other: 3D Imaging<br>* roadmapping of electrophysiology (EP) procedures<br>Other: Late Gadolinium Enhancement (LGE)<br>* useful for delineating abnormal myocardium, including fibrotic regions that can serve as sources of arrhythmias.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Paired-sample Wilcoxon signed rank test to evaluate measures on Likert scales |  | 3 Years | 
| Paired-sample t tests for quantitative measures of intensity of image artifacts |  | 3 Years |