COVID 19 Seroprevalence Amongst Healthcare Workers in JHAH

Study Overview
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Brief Summary
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Healthcare workers play a critical role in fighting the pandemic, not only by managing the patients' health clinically, but also by implementing adequate measures for infection prevention and control in healthcare facilities. This puts healthcare workers at a greater risk of acquiring the disease. COVID-19 is caused by Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2) and many people can be infected with it asymptomatically and undetectably. Serology is an antibody test that provides additional information to polymerase chain-reaction (PCR) testing as it is the only way to reliably establish the fraction of the population that was infected . Seroconversion is the development of antibodies in the blood which can confirm suspected cases after the fact and reveal who was infected but asymptomatic and never realized it. Antibodies are specific proteins created as the body's response to the infection and this test is essential for detecting infected individuals with few or no symptoms at all.

Official Title
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COVID 19 Antibody Seroprevalence Amongst Healthcare Workers in Johns Hopkins Aramco Healthcare

Conditions
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COVID 19

Intervention / Treatment
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* Diagnostic Test: Serology Test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult. JHAH employee Housekeepers (this group of staff are outsourced at JHAH) Exclusion Criteria: 1. Any participant exhibiting COVID 19 symptoms

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| High-risk<br>Employees at high-risk of Coronavirus exposure areas (physicians, nurses, respiratory therapists, radiology technologists, lab technologists, housekeepers) | Diagnostic Test: Serology Test<br>* Participants will be seen at T0 (baseline),T2 (2 months after T0), and T4 (2 months after T2). at every visit, participants will be asked to complete a general surveillance survey and a blood sample will be taken for the serology test.<br>|
| Low-risk<br>Employees working at lower risk areas such as (administration, HR, Public relations) | Diagnostic Test: Serology Test<br>* Participants will be seen at T0 (baseline),T2 (2 months after T0), and T4 (2 months after T2). at every visit, participants will be asked to complete a general surveillance survey and a blood sample will be taken for the serology test.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Seroconversion status | Percentage of health care workers with positive serological markers to describe patterns in exposure, re-infection, clinical symptom, serological responses among health care workers based on their baseline serological status over a one year period. | 6 Months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The proportion of asymptomatic infections among staff who have seroconverted | Seroconversion without clinical manifestation (fever, body aches, headache, sweating, chills + respiratory symptoms (cough dyspnea, sputum) or digestive (nausea / vomiting diarrhea abdominal pain) | 6 Months | 
| The durability of COVID 19 seroconversion in asymptomatic healthcare workers at JHAH | To identify the durability of antibody seroconversion | 6 Months | 
| Identification of risk factors for COVID 19 seroconversion in asymptomatic healthcare workers | Age, gender, type of staff, resources | 6 Months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COVID 19, Coronavirus, SARS-CoV-2