Interactions of Brain Regions in Visuomotor Adaptation

Study Overview
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Brief Summary
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The purpose of this study is to better understand the roles the cerebellum, basal ganglia, and thalamus play in motor learning. Patients undergoing High Intensity Focused Ultrasound (HIFU) treatment will be receiving an ablation procedure to their thalamus as a part of their medical procedure. Participation in this study will include completing a behavioral task before and after the procedure to see how motor learning task performance differs with and without the thalamus. Similarly, patients undergoing Deep Brain Stimulation (DBS) treatment will have an electrode implanted in their thalamus as a part of their medical procedures. Participation in this study will include completing the motor learning task performance on and off thalamic electrical stimulation.

Official Title
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Functional Interaction of Thalamus, Basal Ganglia, and the Cerebellum in Visuomotor Adaptation

Conditions
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High Intensity Focused Ultrasound, Deep Brain Stimulation

Intervention / Treatment
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* Behavioral: Behavioral Assessment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Be a patient receiving either high intensity focused ultrasound treatment or deep brain stimulation treatment for Tremor Able to provide informed consent and complete study procedures Must speak English Age 18-85 Exclusion Criteria: Not receiving one of the specified inclusion criteria Unable to provide consent or complete study procedures Women who self-report pregnancy Patients who are currently incarcerated

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: High Intensity Focused Ultrasound<br>Patients receiving high intensity focused ultrasound as a treatment will be asked to complete the behavioral task pre and post their treatment. | Behavioral: Behavioral Assessment<br>* Patients will be asked to complete the behavioral assessment before and after their HIFU treatment or on and off their DBS treatment.<br>|
| Experimental: Deep Brain Stimulation<br>Patients receiving deep brain stimulation as a treatment will be asked to complete the behavioral task while their DBS electrode is on and off. | Behavioral: Behavioral Assessment<br>* Patients will be asked to complete the behavioral assessment before and after their HIFU treatment or on and off their DBS treatment.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Performance Error on Visuomotor Task | The visuomotor task has practice, baseline, and experimental trials. Performance on the task will be compared between groups (HIFU treatment and DBS treatment) before and after treatment. | baseline, a week after HIFU treatment, several weeks after DBS implantation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ultrasound, Thalamus, Cerebellum, Basal Ganglia, Deep Brain Stimulation, High Intensity Focused Ultrasound