Palmoplantar Pustulosis and Generalized Pustular Psoriasis: A National Population-based Analysis of Prevalence

Study Overview
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Brief Summary
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This study plans to calculate the prevalence and incidence of palmoplantar pustulosis and generalized pustular psoriasis based on the national medical insurance data and analyze the composition characteristics and some clinical features of patients, through taking into account of the research status of palmoplantar pustulosis and generalized pustular psoriasis and the characteristics of medical insurance data.

Official Title
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Palmoplantar Pustulosis and Generalized Pustular Psoriasis: A National Population-based Analysis of Prevalence

Conditions
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Palmoplantar Pustulosis, Generalized Pustular Psoriasis

Intervention / Treatment
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* Other: prevalence/incidence


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The insured population of the national urban employee basic medical insurance and the urban resident basic medical insurance from January 1, 2012, to December 31, 2016 (60 months) (the denominator) The patients have been diagnosed with palmoplantar pustulosis or generalized pustular psoriasis (including disease name, English abbreviation and ICD code) Both outpatient and inpatient patients are included Exclusion Criteria: The individuals whose information is only contained in the reimbursement settlement database but not in the insurance coverage database will be considered as invalid reimbursement individuals and be excluded from the study (the denominator) The patients have been diagnosed with non-PPP and -GPP diseases, such as pustular psoriasis in palm and toe, pustular arthritis osteitis and SAPHO syndrome
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| PPP and GPP<br>Palmoplantar pustulosis (PPP) and Generalized pustular psoriasis (GPP) are rare chronic inflammatory skin diseases, characterized by repeated episodes of sterile pustules in several months or years, associated with erythrokeratodermia generally. Both two diseases are easy to cause skin rupture, leading to bleeding and pain. | Other: prevalence/incidence<br>* It is an observational study for prevalence/incidence, no intervention provided.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prevalence of Palmoplantar pustulosis | Epidemiological characteristics of diseases: Mainly referring to indicators that could reflect the frequency related to the disease | From 2012 to 2016 in the Urban Employee Basic Medical Insurance (UEBMI) data of China | 
| prevalence of Generalized pustular psoriasis | Epidemiological characteristics of diseases: Mainly referring to indicators that could reflect the frequency related to the disease | From 2012 to 2016 in the Urban Employee Basic Medical Insurance (UEBMI) data of China | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| incidence of Palmoplantar pustulosis | Epidemiological characteristics of diseases: Mainly referring to indicators that could reflect the frequency related to the disease | From 2012 to 2016 in the Urban Employee Basic Medical Insurance (UEBMI) data of China | 
| incidence of Generalized pustular psoriasis | Epidemiological characteristics of diseases: Mainly referring to indicators that could reflect the frequency related to the disease | From 2012 to 2016 in the Urban Employee Basic Medical Insurance (UEBMI) data of China | 
| Economic burden of Palmoplantar pustulosis | Mainly referring to the consumption of medical resources, including medical expenses of patients. | From 2012 to 2016 in the Urban Employee Basic Medical Insurance (UEBMI) data of China | 
| Economic burden of Generalized pustular psoriasis | Mainly referring to the consumption of medical resources, including medical expenses of patients. | From 2012 to 2016 in the Urban Employee Basic Medical Insurance (UEBMI) data of China | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Generalized pustular psoriasis, Palmoplantar pustulosis, Urban Employee Basic Medical Insurance (UEBMI) data, prevalence, incidence