Identifying Prostate Brachytherapy Seeds Using MRI

Study Overview
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Brief Summary
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This study will look at the feasibility of using a type of Magnetic Resonance Imaging called Susceptibility Weighted Imaging (SWI) to detect your implanted radioactive seeds. Researchers hope that using SWI will eliminate the need to use CT imaging to detect your implanted radioactive seeds. This study will also see if the MRI seed detection is as effective as current standard practice of seed detection (routine MRI and CT imaging). This technique would be beneficial for brachytherapy without the need to fuse the MRI and CT images, as is done currently.

Official Title
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Identifying Prostate Brachytherapy Seeds Using MRI

Conditions
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Prostate Cancer Patients Who Have Brachytherapy Seed Implant

Intervention / Treatment
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* Other: MRI Scan


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: At least 18 years old Histologic diagnosis of adenocarcinoma of the prostate No contraindications for Pelvic body MRI Patients undergoing LDR brachytherapy at PMH and scheduled for post implant analysis with CT-MR (standard at PMH) Ability to provide written informed consent to participate in the study Exclusion Criteria: Contraindication for Pelvic body MRI Patient not willing/consenting for this study

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: MRI Scan<br>Patients will receive an extra MRI scan in addition to their routine scan. | Other: MRI Scan<br>* Patient will receive an additional MRI scan in addition to their standard of care imaging<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determine if using the MR scan -(SWI) used to detect the implanted radioactive seeds will reduce registration errors |  | 6 months | 
| Determine if using the MR scan -(SWI) used to detect the implanted radioactive seeds will reduce planning time for the post-implant plan |  | 6 months | 
| Determine if using the MR scan -(SWI) used to detect the implanted radioactive seeds will eliminate the CT scan of the patient. |  | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Compare the differences in MR seed identification using the MR pulse sequence vs. CT images. | Our goal is to perfectly match these two modalities with acceptance test of 97%. This technique would be beneficial for LDR (Low Dose Rate) Brachytherapy without need to fuse the CT and MR images and eliminate any image registration uncertainly. | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Prostate cancer, Brachytherapy, Seed implant