Effects of Aerobic Exercise Detraining

Study Overview
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Brief Summary
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The proposed study seeks to better understand the role of body weight, energy expenditure, and energy intake as mechanisms of body weight gain during detraining following aerobic exercise. It is hypothesized that participants in the higher dose exercise group will have greater body weight gain compared to the lower exercise dose and control group from wk 24 to wk 76 follow-up.

Detailed Description
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Eligibility criteria include having successfully completed the main E-Mechanic study, be willing to archive blood samples and not being currently enrolled in another study that may effect body, energy intake or energy expenditure. The investigators will measure body weight, waist/hip circumference, blood pressure, body composition, physical activity, questionnaire about appetite/food intake and physical fitness.

Official Title
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Effects of Aerobic Exercise Detraining on Energy Balance in Overweight Persons

Conditions
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Motor Activity, Body Weight, Obesity

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Completed the E-Mechanic study Be willing to archive blood samples Not participating in a study that would alter body weight, energy intake, or energy expenditure.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 67 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy Living<br>non exercise healthy living control group | |
| General Health<br>Exercise Group (8 KKW) One exercise group will obtain 8KKW (kcal/kg/week) over 3-4 sessions per week, which will result in each session lasting approximately 30 minutes. We will recruit 1 year post study intervention. | |
| Weight Loss<br>Exercise Group (20 KKW) Exercise group will obtain 20 KKW, perform in 4-5 sessions per week for approximately 50-70 minutes per session. We will recruit 1 year post study intervention. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body Weight | Fasting body weight | Week 64 - 88 post study randomization | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Energy Expenditure | Energy expenditure is calculated with the Sensewear Armband. | Week 64 - 90 since study randomization | 
| Energy Intake | Energy expenditure is calculated with the Sensewear Armband and furthermore, energy intake is calculated by adjusting TDEE for change in body weight following the methods used in doubly labeled water adjustment. | Week 64 - 90 post study randomization | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Physical Inactivity, Aerobic Exercise Detraining, Body Weight, Energy Expenditure, Metabolic Syndrome