Correlation Between Intestinal Microecology Imbalance and Stroke in Young Adults

Study Overview
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Brief Summary
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The relationship between the intestinal microecology and stroke has become a research hotspot in neurology field today. Maintaining the balance of the intestinal microbiota are expected to bring new breakthroughs for prevention and treatment of stroke. In recent years, stroke in young adults has an increasing incidence and a considerable socioeconomic impact because of high disability rate and health-care costs. So there is an urgent need to explore the role and mechanism of intestinal microecology imbalance in stroke, especially in the development and prognosis of stroke in young people. This study aims to use multi-omics technologies, including microbial diversity, metagenomics and metabonomics, to reveal the characteristics of intestinal flora in young stroke patients, identify biomarkers for predicting outcome after stroke and early detection of young people at high risk of stroke, and to further explore the role of gut-brain axis in the pathogenesis of stroke.

Official Title
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Research on Correlation Between Intestinal Microecology Imbalance and the Risk and Prognosis of Stroke in Young Adults

Conditions
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Ischemic Stroke, Hemorrhagic Stroke

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical diagnosis of acute ischemic or hemorrhagic stroke Admission within 12 hours Aged 18-45 years Exclusion Criteria: History of neurological diseases, myocardial infarction, renal and hepatic abnormalities and metabolic diseases Combined with tumors, inflammatory bowel disease and other digestive system diseases Combined with serious life-threatening diseases or condition Any antibiotics, probiotics or prebiotic treatment within 3 months Deteriorate and die before collecting faecal samples

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Ischemic stroke<br>Young patients who suffered from acute ischemic stroke within 12 hours for the first time before entry into the study. | |
| Hemorrhagic stroke<br>Young patients who suffered from acute hemorrhagic stroke within 12 hours for the first time before entry into the study. | |
| Healthy Controls<br>Healthy young people | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Modified Rankin Scale scores | 0 = No symptoms; 1 = No significant disability. Able to carry out all usual activities, despite some symptoms; 2 = Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities; 3 = Moderate disability. Requires some help, but able to walk unassisted; 4 = Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted; 5 = Severe disability. Requires constant nursing care and attention, bedridden, incontinent; 6 = Dead. | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ischemic stroke, hemorrhagic stroke, intestinal microecology, multi-omics analysis, prognosis