Brain Markers of Suicide Risk and Psychological Pain in Elderly Depressed Patients

Study Overview
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Brief Summary
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The main objective of this study is to show MRI functional and structural differences between depressed elderly patients with a history of attempted suicide compared to depressed elderly patients with no history of attempted suicide and to elderly subjects with no personal history of depression or attempted suicide (healthy controls).

Official Title
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Brain Markers of Suicide Risk and Psychological Pain in Elderly Depressed Patients

Conditions
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Depressive Disorder, Suicide, Attempted

Intervention / Treatment
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* Other: MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The patient must have given their free and informed consent and signed the consent form be a member or beneficiary of a health insurance plan aged 60 years-old or more must be right-handed with a diagnosis of a current major depressive episode of moderate to severe severity according to diagnostic criteria. with or without a personal history of attempted suicide during life hospitalized or followed by a consultant in the department of Psychiatry of Nîmes University Hospital or in the Sophoras private clinic Exclusion Criteria: The subject is participating in an interventional study, or is in a period of exclusion determined by a previous study under safeguard of justice refuses to sign the consent It is impossible to give the subject informed information Current psychotic symptoms. Bipolar disorder. The subject presents an acute somatic decompensation incompatible with the realization of this study. The patient presents a mental confusion or a known Mini Mental State Examination score <24. Central neurological disease known in particular degenerative pathology, severe cranial trauma and severe cerebrovascular disease. Schizophrenia and other known psychotic disorders. Electroconvulsive therapy in the 12 months prior to study Inability to perform neuropsychological tests because of a language problem, poor understanding, a major tremor, inability to sit still, a major sight problem that cannot be corrected, or other severe cognitive impairment Contra-indication to magnetic resonance imaging (MRI): ferromagnetic implant in the body, piercing, claustrophobia, inability to remain elongated for 45 minutes.

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Suicide attempters<br>Depressed patients over 60 years of age with a personal history of suicide attempts scanned with MRI | Other: MRI<br>* Structural and functional sequences<br>|
| Patient controls<br>depressed patients over 60 years of age without a personal history of suicide attempt scanned with MRI | Other: MRI<br>* Structural and functional sequences<br>|
| Healthy Controls<br>Healthy subjects over 60 years, not depressed and without personal history of severe mental illness or suicide attempts, scanned with MRI | Other: MRI<br>* Structural and functional sequences<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Brain functional activity during unfairness | Contrast in BOLD signal measured by 3T-Magnetic Resonance Imaging (MRI) during the fair vs unfair trials of the Ultimatum Game | Day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Brain structural volumes | T1 sequence measured by MRI in each participant | Day 0 | 
| Brain structural connectivity | Diffusion Tensor Imaging measured by MRI in each participant | Day 0 | 
| Brain functional connectivity | Resting state activity measured by MRI in each participant | Day 0 | 
| Correlation of MRI measures with psychological pain measures | Psychological pain will be measured by the Visual Analog Scale (Olié et al. 2010) in each participant | Day 0 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Elderly, MRI