Multicenter Study of Impulse Oscillometry in Chinese

Study Overview
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Brief Summary
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The purpose of this study is to establish the reference values of impulse oscillometry (IOS) in healthy Chinese, and compare the indices of IOS in patients with lung disease, such as chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease (ILD), and upper airway Obstruction (UAO).

Official Title
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Multicenter Study of Impulse Oscillometry in Chinese

Conditions
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Healthy Subjects, Chronic Obstructive Pulmonary Disease, Asthma, Interstitial Lung Disease, Upper Airway Obstruction

Intervention / Treatment
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* Other: Clinical Observation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria for healthy subjects: life-long non-smokers no symptoms and history of chronic cardiopulmonary diseases (chronic bronchitis, asthma, lung cancer, pulmonary fibrosis, pulmonary tuberculosis, chronic heart diseases, etc.) no abnormal findings on physical examination written informed consent was obtained Inclusion Criteria for COPD: Diagnosis of chronic obstructive pulmonary disease (COPD), as classified by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines and post-bronchodilator FEV1/FVC (forced vital capacity) < 70%. Inclusion Criteria for asthma: Diagnosis of asthma, as classified by national and international asthma guidelines. Inclusion Criteria for ILD: ILD diagnosis confirmed by lung biopsy, X ray or BALF analysis. Inclusion Criteria for UAO: Diagnosis of UAO. Exclusion Criteria for healthy subjects: upper or lower respiratory infection within 4 weeks long-term exposure to harmful gas or particles using β-blocker for treatment pregnant women, epileptic other diseases or surgeries potentially affecting lung function

Ages Eligible for Study
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Minimum Age: 4 Years
Maximum Age: 95 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy subjects<br>Healthy subjects. | Other: Clinical Observation<br>* No treatment given but observation with IOS<br>|
| Chronic obstructive pulmonary disease<br>Patience with chronic obstructive pulmonary disease. | Other: Clinical Observation<br>* No treatment given but observation with IOS<br>|
| Asthma<br>Patience with asthma. | Other: Clinical Observation<br>* No treatment given but observation with IOS<br>|
| Interstitial lung disease<br>Patience with interstitial lung disease. | Other: Clinical Observation<br>* No treatment given but observation with IOS<br>|
| Upper airway obstruction<br>Patience with upper airway obstruction. | Other: Clinical Observation<br>* No treatment given but observation with IOS<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Airway resistance | The indices of Airway resistance include total respiratory impedance (Zrs). | one minute | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC, and maximum midexpiratory flow (MMEF). | The indices of spirometry include forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC, and maximum midexpiratory flow (MMEF). | one minute | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Impulse Oscillometry, Chinese, Healthy Subjects, Chronic Obstructive Pulmonary Disease, Asthma, Interstitial Lung Disease, Upper Airway Obstruction, Reference Values