Effects of Coffee Roasting on Blood Sugar Levels in Healthy Humans

Study Overview
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Brief Summary
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The present study determined the effects light, medium, and dark roasted, brewed coffees on blood glucose responses in normal (n = 19) subjects.

Detailed Description
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This is a single-blinded, randomized partial block design conducted over 6 weeks in two parts. In part 1 (3 weeks), participants were randomly assigned to consume four beverages: a placebo containing water and caramel color, light, medium, or dark roast coffee before, during, or after consumption of a beverage containing 50 g of glucose. In part 2 (3 weeks), participants were randomly assigned to consume four beverages: a placebo containing water and caramel color, light, medium, or dark roast coffee before, during, or after consumption of a standardized breakfast (corn flakes cereal + skim milk) containing 50 g of glucose. In each part, fasting and postprandial glucose profiles were determined.

Official Title
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Effects of Coffee Roasting on Blood Sugar Levels in Healthy Humans

Conditions
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Hyperglycemia

Intervention / Treatment
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* Dietary Supplement: Placebo Comparator
* Dietary Supplement: Light Roasted Coffee
* Dietary Supplement: Medium Roasted Coffee
* Dietary Supplement: Dark Roasted Coffee


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • Age 18-64 years old with BMI less than 29 and fasting blood glucose less than 125 mg/dl. Exclusion Criteria: Age 18-64 years old with BMI less than 29 and fasting blood glucose less than 125 mg/dl. Weight less than 110 pounds (55 kg) Pre-existing health conditions, such as: High cholesterol Hypertension Cardiovascular disease Gastrointestinal motility disorders Hypo- or hyperthyroidism Anemia Renal disease Liver disease, including hepatitis B or C, cholestasis, cirrhotic liver disease, or non-alcoholic fatty liver disease Chronic or acute pancreatitis Diabetes type 1 or 2 Insulin resistance Polycystic ovary syndrome Food allergies or intolerances to coffee/caffeine/dairy/corn-based cereals. Currently taking prescription medication Current smoker Consumes more than 3 alcoholic beverages per day Pregnant or breastfeeding Not willing to take their own blood samples with finger sticks

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: Randomized, single-blinded, partial block, crossover design
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo Comparator<br>Placebo composed of water and caramel color. | Dietary Supplement: Placebo Comparator<br>* Placebo designed to mimic coffee color.<br>|
| Experimental: Light Roasted Coffee<br>12 oz light roast coffee beverage prepared at 55 g ground coffee/L water | Dietary Supplement: Light Roasted Coffee<br>* 12 oz light roast coffee<br>|
| Experimental: Medium Roasted Coffee<br>12 oz medium roast coffee beverage prepared at 55 g ground coffee/L water | Dietary Supplement: Medium Roasted Coffee<br>* 12 oz medium roast coffee<br>|
| Experimental: Dark Roasted Coffee<br>12 oz dark roast coffee beverage prepared at 55 g ground coffee/L water | Dietary Supplement: Dark Roasted Coffee<br>* 12 oz dark roast coffee<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in Blood Glucose | Each week, fasted baseline and postprandial measurements taken out to 240 minutes | 6 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in Glucose Area Under the Curve | Used glucose changes over 240 minutes to construct area under the curve | 6 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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coffee, glucose challenge, blood glucose levels