MgSO4 Combined With Rocuronium Priming

Study Overview
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Brief Summary
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Priming with either rocuronium or MgSO4 is known to accelerate the effect of rocuronium on muscle relaxation. The purpose of this study is to define the effect of MgSO4 on the rocuronium-priming.

Detailed Description
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Acceleration of muscle relaxation is beneficial in rapid-sequence intubation. If MgSO4 combined with priming is efficient in accelerating muscle relaxation, it would be an interesting alternative to rapid-sequence intubation.

Official Title
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MgSO4 Combined With Rocuronium Priming

Conditions
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Muscle Relaxation

Intervention / Treatment
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* Drug: magnesium sulfate
* Drug: priming
* Drug: magnesium sulfate and priming


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients of ASA Ⅰ-Ⅱ aged 18 65 scheduled to undergo elective surgery under general anesthesia Exclusion Criteria: risk of pulmonary aspiration anticipated airway difficulty reactive airway disease allergic to study drugs neuromuscular / cardiovascular/ renal/ hepatic disease atrioventricular conduction disturbance BMI < 18.5 or > 24.9 chronic treatment with calcium channel blocker medications which affect muscle relaxation

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Roc<br>Patients in this group receive neither MgSO4 nor priming dose of rocuronium. | |
| Active Comparator: priming<br>patients in this group receive 0.06mg/kg of rocuronium before 0.54mg/kg of rocuronium. | Drug: priming<br>* Patients in this group receive 0.06mg/kg of rocuronium before administration of 0.54mg/kg of rocuronium.<br>* Other names: rocuronium-priming;|
| Experimental: Mg&priming<br>Patients in this group receive MgSO4 50mg/kg and 0.06mg/kg of rocuronium before administration of 0.54mg/kg of rocuronium. | Drug: magnesium sulfate and priming<br>* Patients in this group receive MgSO4 50mg/kg and 0.06mg/kg of rocuronium before administration of 0.54mg/kg of rocuronium.<br>* Other names: MgSO4 & priming;|
| Active Comparator: MgSO4<br>Patients in this group receive intravenous MgSO4 before administration of rocuronium. | Drug: magnesium sulfate<br>* Patients in this group receive intravenous MgSO4 50mg/kg before administration of rocuronium (induction dose).<br>* Other names: MgSO4;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| time from injection of induction dose of rocuronium until 95% depression of TOF |  | time from injection of induction dose of rocuronium until 95% depression of TOF, upto 5 min | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rocuronium duration | time from injection of induction dose of rocuronium until train-of-four count reaches two. | time from injection of induction dose of rocuronium until train-of-four count reaches two. | 
| intubating condition | rapid sesequence intubation condition is evaluated. | time from injection of induction dose of rocuronium until tracheal intubation. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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rocuronium, muscle relaxation, magnesium sulfate