Diagnoses Associated With Persistent Elevation of Creatine Kinase

Study Overview
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Brief Summary
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Serum creatinine kinase (CK) level varies with age, gender, race and physical activity. For these reasons there is no normal serum CK level. Many pathological situations cause hyperCKemia, such as neuromuscular disorders (muscular dystrophy, inflammatory myositis, mitochondrial myopathy) and multiple systemic causes. The diagnostic approach to pauci or asymtomatic hyperCKemia can therefore be difficult and lead to multiple, and sometimes invasive tests, such as muscle biopsy. This study aims to describe the diagnoses associated with persistent elevation of serum creatine kinase and to precise the role of the muscule biopsy.

Official Title
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Diagnoses Associated With Persistent Elevation of Creatine Kinase

Conditions
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Creatine Kinase, Muscular Diseases

Intervention / Treatment
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* Other: no intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients hospitalised in a ward of internal medicin having a persistent elevation of serum creatine kinase >3 times the upper normal laboratory value, repeated for 2 times Exclusion Criteria: known neuro-muscular disease causing elevation of creatine kinase evident post-traumatic cause responsible for the elevation of creatine kinase incomplete medical records

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with elevated creatine kinase<br> | Other: no intervention<br>* retrospective descriptive without intervention<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnosis | The final diagnosis, as written in the medical record at the end of the investigations in the ward of internal medicin, responsible for the elevation of creatine kinase between: inflammatory myositis, mitochondrial myopathy, muscular dystrophy, non neuromuscular pathology | at the end of all investigations, an average of 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle biopsy | Among the patients who underwent a muscle biopsy, number of anormal biopsies that contributed to make the final diagnosis responsible of the elevation of creatine kinase | at the end of all investigations, an average of 12 months | 
| Clinical presentation | association between the initial clinical presentation and the final diagnosis | at the end of all investigations, an average of 12 months | 
| Paraclinical presentation | association between the initial paraclinical presentation and the final diagnosis | at the end of all investigations, an average of 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Creatine Kinase