Autonomic Nervous System, Fatigue and Intolerance to Physical Training, and Overtraining in High-Level Athletes

Study Overview
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Brief Summary
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Sports training aims to enhance an athlete's performance (overcompensation). To do that, the athlete must go through periods of fatigue and lower performance (overreaching). When the training plan is balanced, this fatigue is short and reversible.If the training load is too heavy or if recuperation periods are too short, it can lead to persistence fatigue that may only be reversible in the long term. This state of fatigue is part of the broader clinical picture of overtraining, which includes stark changes in performance as well as mood and sleep disorders. Many prediction and characterization methods based on biological markers have been evaluated, but they have not been put into practice in sports training due to obstacles such as reliability, interindividual variability and high costs. This study aims to evaluate a new approach based on the variability of an individual's heart rate (RR variability), which is a way of measuring autonomic nervous system (ASN) activity. It is non-invasive, low-cost, and has already proven useful in athlete health monitoring.

Detailed Description
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The investigators propose to describe the variation of these ANS regulation factors over a full year, in a population of high-level athletes, in order to measure changes in regulation which may be predictive of potential fatigue and intolerance to physical training, if such a syndrome came to be observed among the study group.

Official Title
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Autonomic Nervous System, Fatigue and Intolerance to Physical Training, and Overtraining in High-Level Athletes. A Multicentre Study

Conditions
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Training, Athletes, Fatigue

Intervention / Treatment
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* Device: ANS activity


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: High-level athlete, enrolled in a Ministry-recognized Pôle Participant signed the informed consent form Exclusion Criteria: Confirmed current overtraining syndrome Known pregnancy on inclusion Athlete using cardio-inhibitor or cardio-accelerator drugs

Ages Eligible for Study
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Minimum Age: 14 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| high-level athletes<br>High-level athlete, enrolled in a Ministry-recognized Pôle | Device: ANS activity<br>* This ANS activity is measured by nocturnal heart rates records with Holter ECG.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Autonomic nervous system (ANS) activity | This ANS is mesured during the night using a spectral analysis of nocturnal heart rate variability. | One year | 
| Fatigue and physical training | Fatigue and physical training potetially due to overtraining, suspected based on a very significant, long-term worsening in performance | One year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| kinetic of the ANS activity | ANS is mesured during the night using a spectral analysis of nocturnal heart rate variability | Every 15 days (from the iclusion to one year) | 
| orthostasis test | ANS activity measurements (RR variability) during active orthostasis transition on waking up in the morning | Every 15 days (from inclusion to one year) | 
| French Society of Sports Medicine questionnaire | The questionnaire was designed to detect early signs of overtraining. It includes 54 yes/no questions. Subjects who answer yes to more than 20 questions are considered at risk for overtraining. | Every 15 days (from inclusion to one year) | 
| POMS (Profile of Mood States) questionnaire |  | Every 3 months (from inclusion to inclusion) | 
| Sleep quality questionnaire | The questionnaire is self-administered. It includes two parts. The first part consists of several questions regarding sleep during the previous night. The second part aims to evaluate the physical exertion load during the previous day's training session(s). Participants will fill one questionnaire/day for a whole week. Each questionnaire period must coincide with a training period (interseason, volume, intensity, or competition.) | Every 3 months (from inclusion to one year) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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High-level athlete, ANS activity, Overtraining