Effect of Serving Size and Addition of Sugar on the Glycemic Response Elicited by Oatmeal

Study Overview
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Brief Summary
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The purpose of this study was to determine the impact of serving size and the addition of sugar on the glycemic response elicited by oatmeal compared to that elicited by cream of rice cereal.

Official Title
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Effect of Varying Amounts of β-glucan and Sucrose in Oatmeal on Glycemic Response

Conditions
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Diabetes Mellitus

Intervention / Treatment
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* Other: Classic Quaker Quick Oats
* Other: Cream of Rice Cereal


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: body mass index (BMI) 20.0 - 34.9 kg/m² Exclusion Criteria: known to have diabetes use of medications considered by the principal investigator to influence glycemic responses

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: 30g oats<br>Classic Quick Quaker Oats | Other: Classic Quaker Quick Oats<br>* Various doses of oats without or with sugar<br>|
| Other: 30g oats plus 9g sugar<br>Classic Quick Quaker Oats | Other: Classic Quaker Quick Oats<br>* Various doses of oats without or with sugar<br>|
| Other: 40g oats<br>Classic Quick Quaker Oats | Other: Classic Quaker Quick Oats<br>* Various doses of oats without or with sugar<br>|
| Other: 60g oats<br>Classic Quick Quaker Oats | Other: Classic Quaker Quick Oats<br>* Various doses of oats without or with sugar<br>|
| Other: 22g cream of rice cereal<br>Cream of Rice Cereal, B&G Foods, Inc. | Other: Cream of Rice Cereal<br>* Various doses of cereal without sugar<br>|
| Other: 29g cream of rice cereal<br>Cream of Rice Cereal, B&G Foods, Inc. | Other: Cream of Rice Cereal<br>* Various doses of cereal without sugar<br>|
| Other: 33g cream of rice cereal<br>Cream of Rice Cereal, B&G Foods, Inc. | Other: Cream of Rice Cereal<br>* Various doses of cereal without sugar<br>|
| Other: 44g cream of rice cereal<br>Cream of Rice Cereal, B&G Foods, Inc. | Other: Cream of Rice Cereal<br>* Various doses of cereal without sugar<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incremental area under the blood glucose response curve |  | For 2 hours after consuming each test meal | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Peak rise of blood glucose | The highest concentration of blood glucose achieved after eating minus the fasting blood glucose. | During 2 hour period after consuming each test meal | 
| Time to peak | The time at which the peak rise of blood glucose occured. | During 2 hour period after consuming each test meal | 
| Mean rate of decline in blood glucose | The rate of change in blood glucose between consecutive time points (Tx and T(x+1)) was calculated as: Rx = (Gx G(x+1))/(Tx-T(x+1)), where G(x+1) and Gx were the glucose concentrations at times T(x+1) and Tx, respectively. The mean rate of decline in blood glucose (Mean RD) was calculated as the weighted average of all the Rx values from the time of the peak glucose concentration to 120 min, with the weight based on the length of the time interval. | During 2 hour period after consuming each test meal | 
| Maximum rate of decline in blood glucose | The rate of change in blood glucose between consecutive time points (Tx and T(x+1)) was calculated as: Rx = (Gx G(x+1))/(Tx-T(x+1)), where G(x+1) and Gx were the glucose concentrations at times T(x+1) and Tx, respectively. . The maximum rate in blood glucose decline (Max RD) was calculated as the maximum of all the Rx values from the time of the peak glucose concentration to 120 min. | During 2 hour period after consuming each test meal | 
| Time to baseline | The time for blood glucose to return to baseline was linearly interpolated between the first blood glucose concentration below fasting and the previous value; if blood glucose did not reach baseline, Bt was taken to be 120min. | During 2 hour period after consuming each test meal | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Blood glucose, Humans, Postprandial, Sugar, Carbohydrate, Oat beta-glucan