Resistance Exercise, Muscle Mass, Strength and Body Composition

Study Overview
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Brief Summary
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A plethora of trials reported the positive effect of resistance exercise on functional and morphological parameters. Although a large amount of the studies used suboptimum devices and obsolete methods the results of these older studies were still considered as golden standard. The aim of the present study is thus to determine the proper effect of different resistance exercise protocols with and without adjuvant protein supplementation on functional and morphological muscle and body composition parameters in male untrained subjects 30-50 years old under special regard of modern medical imaging and segmentation technologies. Our general study hypothesis is that HIT-resistance exercise significantly impact relevant muscular parameters of the upper leg.

Official Title
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Effects of Resistance Exercise on Muscle Mass, Strength, Body Composition and Heart in Men 30-50 Years Old.

Conditions
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Sarcopenia, Obesity

Intervention / Treatment
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* Other: HIT-exercise, low repetition range
* Other: HIT-exercise, high repetition range
* Other: HIT-exercise with protein
* Other: Control


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: males untrained (< 2 h exercise/week, < 1 h resistance exercise/week) 30-50 years old Exclusion Criteria: medication/diseases affecting intervention or study endpoints history of intense resistance exercise (> 3 h/week during the last decade) very low physical capacity (< 100 Watt at ergometry) more than 2 weeks of absence during the interventional period contraindication related to MRI-assessment (i.e. magnetizable intracorporal artefacts) pathological changes of the heart inflammable diseases

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: HIT-exercise, low repetition range<br>High Intensity Resistance Exercise Training, low repetition range, > 75% 1 Repetition Maximum (1RM) | Other: HIT-exercise, low repetition range<br>* High Intensity Resistance Exercise Training, low repetition range, > 75% 1RM<br>|
| Experimental: HIT-exercise, high repetition range<br>High Intensity Resistance Exercise Training, high repetition range, 60 - <75% 1RM | Other: HIT-exercise, high repetition range<br>* High Intensity Resistance Exercise Training, high repetition range, 60 - < 75 1RM<br>|
| Experimental: HIT-exercise with protein<br>High Intensity Resistance Exercise Training with protein supplementation | Other: HIT-exercise with protein<br>* High Intensity Resistance Exercise Training, low repetition range, > 75% 1RM and Protein Supplementation<br>|
| Placebo Comparator: Control<br>No physical exercise intervention | Other: Control<br>* control group, no intervention, maintenance of physical activity<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| fat free Cross Sectional Area (CSA) upper leg | fat free muscle cross sectional area of the upper leg at mid-femur via Quantitative Computed Tomography (QCT) | change from baseline in fat free Cross Sectional Area at 5 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CSA upper leg | muscle cross sectional area of the upper leg at mid-femur via QCT | change from baseline in CSA upper leg at 5 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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resistance exercise, muscle mass, abdominal fat, strength, Coronary Heart Disease (CHD)-risk, myocardial mass