The Effects of Whole Body Vibration in People With Chronic Stroke

Study Overview
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Brief Summary
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Whole body vibration (WBV) has been found to be useful in promoting bone health and muscle performance in older adults. To date, no study has examined the effects of different WBV frequencies on the properties of the muscle-bone unit in stroke patients. The overall aim of the proposed study is to compare the efficacy of different vibration frequencies on properties of the muscle function and bone turnover among people with chronic stroke. It is hypothesized that the higher-vibration frequency protocol will lead to significantly better outcomes related to the bone turnover and muscle function.

Detailed Description
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Whole body vibration (WBV) has been found to be useful in promoting bone health and muscle performance in older adults. To date, no study has examined the effects of different WBV frequencies on the properties of the muscle-bone unit in stroke patients. The overall aim of the proposed study is to compare the efficacy of different vibration frequencies on properties of the muscle function and bone turnover among people with chronic stroke. It is hypothesized that the higher-vibration frequency protocol will lead to significantly better outcomes related to the bone turnover and muscle function in people with chronic stroke.

Official Title
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The Effects of Whole Body Vibration Training With Different Frequencies on Bone Health and Neuromotor Performance in Individuals With Chronic Stroke: A Randomized Controlled Trial.

Conditions
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Stroke

Intervention / Treatment
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* Procedure: High frequency whole body vibration
* Procedure: Low frequency whole body vibration


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: a diagnosis of stroke stroke onset >6 months >18 years of age able to walk for short distance independently with or without walking aid able to understand simple verbal commands Exclusion Criteria: neurological conditions other than stroke significant musculoskeletal conditions (e.g. amputations) metal implants in the lower extremity previous fracture of the lower extremity are currently taking bone resorption inhibitors or were taking the same before stroke. significant peripheral vascular disease vestibular disorders pregnancy Other serious illnesses that preclude the person from participating in the study

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: High frequency whole body vibration<br>This group will receive a single 8-minute session of WBV therapy. The frequency of the vibration signals will be set at 30Hz. | Procedure: High frequency whole body vibration<br>* 1 single session ( 8 minutes) of whole body vibration therapy at 30 Hz<br>* Other names: Whole body vibration therapy (30Hz);|
| Active Comparator: low frequency whole body vibration<br>This group will receive a single 12-minute session of WBV. The frequency of the vibration signals will be set at 20 Hz. | Procedure: Low frequency whole body vibration<br>* 1 single session ( 12 minutes) of whole body vibration therapy at 20 Hz<br>* Other names: Whole body vibration therapy (20Hz);|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| bone resorption marker | Serum level of aminoterminal crosslinked telopeptide | pre-test (week 0) | 
| bone resorption marker | Serum level of aminoterminal crosslinked telopeptide | post-test (week8) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Six Minute Walk Test | endurance test | pre-test (week 0) | 
| Six Minute Walk Test | endurance Test | post-test (week8) | 
| Gait velocity | 10-meter walking test | pre-test (week 0) | 
| Gait velocity | 10-meter walking test | post-test (week8) | 
| Spasticity | H-reflex on tibial nerve and modified ashworth scale | pre-test (week 0) | 
| Spasticity | H-reflex on tibial nerve and modified ashworth scale | post-test (week8) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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vibration, bone, mucle, cerebrovascular accident, rehabilitation