Using Open Contest and Neuro-influence Experiment to Develop and Evaluate PrEP Promotion Messages for High Risk Men

Study Overview
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Brief Summary
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The aim of this study is to examine the utility of neuroimaging technique to evaluate pre-exposure prophylaxis (PrEP) promotion messages for men who have sex with men (MSM) at risk of HIV in Baltimore.

Detailed Description
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This study will examine the utility of neuroimaging technique to evaluate PrEP promotion messages for MSM at risk of HIV in Baltimore. The investigators hypothesize that participants viewing top messages developed via open contests will show higher brain activation in the Medial Prefrontal Cortex (MPFC) regions than those viewing messages developed by a social marketing approach. The investigators further hypothesize brain activation in the MPFC regions is significantly more correlated with PrEP behavioral intention, initiation, and action than self-reported message effectiveness.

Official Title
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Using Open Contest and Neuro-influence Experiment to Develop and Evaluate PrEP Promotion Messages for High Risk Men

Conditions
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HIV/AIDS

Intervention / Treatment
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* Behavioral: PrEP campaign messages developed via open contest
* Behavioral: PrEP campaign messages developed via social marketing approach


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 years and older Biological male sex at birth Sexually active with men in the past 6 months Never taken PrEP HIV negative Reside in Baltimore City or surrounding counties Meet one of the criteria for being an appropriate PrEP candidate (i.e. in a relationship with a partner not known to be HIV-negative; are in a nonmonogamous relationship; have had any condomless anal sex with a casual male partner regardless of status in the prior 6 months; or had a positive sexual transmitted infection (STI) diagnosis within the prior 6 months). Exclusion Criteria: - Participated in open contest

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Open contest messages<br>Participants will view the top PrEP-promotion messages developed via an open contest. | Behavioral: PrEP campaign messages developed via open contest<br>* PrEP campaign messages will be developed via an open contest in Baltimore.<br>|
| Active Comparator: Social marketing messages<br>Participants will view the PrEP-promotion messages developed via social marketing. | Behavioral: PrEP campaign messages developed via social marketing approach<br>* PrEP campaign messages developed with a traditional social marketing approach.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change of neural activity | change of the ratio of oxygenated (O2HB) to deoxygenated (HHB) hemoglobin in the Medial Prefrontal Cortex (MPFC) regions measured by functional near infrared spectroscopy (fNIRS) | 20 seconds between participants start and finish reviewing the messages | 
| change of willingness and behavioral intention to take PrEP | questions on willingness and behavioral intention to take PrEP. Participants will be asked, Suppose that PrEP is at least 90% effective in preventing HIV when taken daily. How likely would you be to take PrEP if it were available for free? with responses ranging from I would definitely take it to I would definitely not take it. Participants will be asked, PrEP is currently available with a prescription from your doctor and research has shown that a majority of insurance companies cover most or all of the costs of PrEP. Do you plan to begin PrEP? Response options range from Yes, I will definitely begin taking PrEP to No, I definitely will not begin taking PrEP. | 30 days between baseline and follow up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PrEP action and initiation | questions on Have you spoken with a provider about PrEP during the past 30 days? and Have you started taking PrEP during the past 30 days? | 30-day follow up | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pre-exposure prophylaxis, Health Promotion, HIV/AIDS primary prevention, men who have sex with men, Neuroimaging