The Relationship Between Single Nucleotide Polymorphisms of Chitinase 3-like 1 Gene,YKL-40 Serum Levels and Adult Asthma

Study Overview
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Brief Summary
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The objective of this study was to investigate the relationship between single nucleotide polymorphism of chitinase 3-like 1 and human asthma.

Detailed Description
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Chitinase 3-like 1 (CHI3L1) is a member of human chitinases family. According to previous studies in literatures, increased expression of CHI3L1 has been proven to be correlated with the presence of different diseases, including cancers, autoimmune diseases, and chronic inflammatory conditions. Elevated serum levels of YKL-40 are associated with increased disease severity, poorer prognosis and shorter survival for many other diseases. When monitored over time, increases in serum YKL-40 parallel with disease progression. It can serve as an measurable marker of changes in disease status. There were indicated that chitinase 3-like 1 might be associated with some clinical diseases. The C-allele of the -131 C→G (rs4950928) polymorphism of CHI3L1 has been shown to associate with bronchial hyperresponsiveness and reduced lung function. It is suggesting that variations in CHI3L1 may influence risk of asthma. The objective of this study was to investigate the relationship between single nucleotide polymorphism of chitinase 3-like 1 and human asthma. The association between CHI3L1 SNPs and the continuous outcomes were examined by real time PCR and gene sequencing analysis. In Korean reports there was no significant associations between CHI3L1 SNPs and asthma were observed. On the other hand, there were association between CHI3L1 and asthma observed in the majority of Caucasian populations. However, similar research has not been conducted in Taiwan. In contrast to preliminary studies, the investigators predict the rs4950928 G allele, and not the C allele, was found to be associated with asthma. The g.-247C/T polymorphism in the CHI3L1 promoter region is associated with the risk of atopy.

Official Title
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The Relationship Between Single Nucleotide Polymorphisms of Chitinase 3-like 1 Gene,YKL-40 Serum Levels and Adult Asthma

Conditions
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Asthma

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ages 20 to 60 years asthma patients atopy patients control (non-asthma and non-atopy)

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Asthma<br>The relationship between single nucleotide polymorphisms of chitinase 3-like 1 gene, YKL-40 serum levels and adult asthma | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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asthma, Chitinase 3-like 1 (CHI3L1), YKL-40, single nucleotide polymorphism(SNP), Real time PCR, gene