linjc16/ctgov huggingface dataset:
A Multicenter Case-control Study of Risk Factors for Premature Ejaculation in China's Shaanxi Province

Study Overview
=================
Brief Summary
-----------------
Through a multicenter case-control study on the risk factors of premature ejaculation in Shaanxi, to find out the related factors of the occurrence and development of premature ejaculation, to provide reference for personalized treatment, in order to improve the quality of sexual life of patients and partners.

Official Title
-----------------
A Multicenter Case-control Study of Risk Factors for Premature Ejaculation in China's Shaanxi Province

Conditions
-----------------
Premature Ejaculation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1) case group 18-64 years old, regular sexual life > 6 months; Self-report of premature ejaculation; Able to complete questionnaires and scale scores independently. 2) control group 18-64 years old, regular sexual life > 6 months; Both partners are satisfied with their sexual life; Able to complete questionnaires and scale scores independently. Exclusion Criteria: 1) case group Those who are unable to have sex due to genital malformation; Patients with serious cardiovascular and cerebrovascular diseases; Severe mental disorders (history of epilepsy, mania, etc.); Have a history of brain trauma; People with a long history of substance abuse. 2) control group Patients with a history of mental illness; Oral selective serotonin (5-ht) reuptake inhibitors, tricyclic antidepressants, triazolidine antidepressants, tramadol and sedatives

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 64 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| IELT | Intra-vaginal Ejaculation Latency Time | Within 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
risk factor
Association Between Embryo Implantation Rate and Maternal Age

Study Overview
=================
Brief Summary
-----------------
To explore the relationship between maternal age and embryo implantation rate in patients undergoing assisted reproductive technology.

Detailed Description
-----------------
The investigators designed a retrospective clinical trial conducted from January 2015 to December 2020 at the Reproductive Medicine Center of the Affiliated Drum Tower Hospital of Nanjing University Medical School. Infertility was defined as the failure of a clinical pregnancy after 12 months or more of regular unprotected intercourse with the same marriage partner. Patients experiencing infertility no younger than the age of 20 who attended the Reproductive Medicine Center of the Affiliated Drum Tower Hospital of Nanjing University Medical School for the first time and had experienced no less than one embryo transplantation between January 2015 and December 2019 were recruited. Patients who had experienced or canceled embryo transplantation cycles for any reason were excluded from this study. The gap year from December 2019 to December 2020 allowed researchers to follow up on the outcomes of pregnancies before 2020. Frozen cycles were performed when high-quality embryos existed to avoid unnecessary ovarian stimulation and oocyte retrieval processes. Investigators were blinded to the outcome of embryo transplantation, and information on pregnancy was gathered through telephone follow-up one year after transplantation.

Official Title
-----------------
Association Between Embryo Implantation Rate and Maternal Age in Different Embryo Transplantation Cycles: a Retrospective Cohort Study

Conditions
-----------------
Infertility, Female

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: infertile patients attended the Reproductive Medicine Center of the Affiliated Drum Tower Hospital of Nanjing University Medical School for the first time had experienced no less than one embryo transplantation between January 2015 and December 2019 Exclusion Criteria: canceled embryo transplantation cycles for any reason

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Infertile females<br>No less than 20 years old who were attending our clinical center for the first time were enlisted | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| embryo implantation rate | Fetal heartbeat can be visualized via ultrasound in order to definitely confirm the implantation of the embryo | 60 days after embryo transplantation |
Perception and Representation of Internal Body in Anorexia Nervosa

Study Overview
=================
Brief Summary
-----------------
This study focuses on representations of the interior of the body and interoceptive awareness in women with anorexia nervosa in comparison with women without eating disorders.

Official Title
-----------------
Perception and Representation of Internal Body in Anorexia Nervosa

Conditions
-----------------
Anorexia Nervosa

Intervention / Treatment
-----------------
* Behavioral: perceptive tests


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Anorexia Nervosa according to DSM-5 aged above than 14 BMI between 14 and 18.5 for adults or less than the reference age by age for minors Exclusion Criteria: Unable to understand the tests, poor understanding of the French language Mental retardation Severe psychiatric comorbidity (bipolar disorder, schizophrenia) Lesion or pathology of the upper limbs Pregnancy Absence of social protection Hospitalization under duress

Ages Eligible for Study
-----------------
Minimum Age: 14 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Anorexia<br>Subjects with anorexia nervosa | Behavioral: perceptive tests<br>* many tests are realized: a drawing of the interior of the body a heartbeat detection test an ischemia induction test many scales: Eating Attitude Test; Body Awareness Questionnaire; Body Shape Questionnaire; Hospital Anxiety and Depression; Questionnaire de Satisfaction Corporelle et de Perception Globale de Soi<br>* Other names: scales;|
| Active Comparator: Control<br>Subjects without eating disorders | Behavioral: perceptive tests<br>* many tests are realized: a drawing of the interior of the body a heartbeat detection test an ischemia induction test many scales: Eating Attitude Test; Body Awareness Questionnaire; Body Shape Questionnaire; Hospital Anxiety and Depression; Questionnaire de Satisfaction Corporelle et de Perception Globale de Soi<br>* Other names: scales;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| drawing | Number and nature of organs drawn | At inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| IAI | interoceptive awareness index | At inclusion | 
| Time | time to obtain a score of 3 on the analogue visual scale at the ischemia induction test | At inclusion | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Body awareness, Interoceptive awareness, Anorexia Nervosa, Adolescent, Body image
Pregnancy Outcomes in Congenital Myasthenie Syndrome

Study Overview
=================
Brief Summary
-----------------
This is a retrospective study that follows the clinical evolution, the pregnancy and the post-partum perioad of female patients with Congenital Myasthenic Syndrome.

Detailed Description
-----------------
The aim of this study is to better understand the action of hormonal factors that are presumably incriminated for the fluctuation of the disease. The investigators would also like to better adress the issues of women with Congenital Myasthenic Syndrome, who desire a pregnancy : the possibility of decompensation, the problems that can arise during the course of the childbearing, the risk of foetal malformations.

Official Title
-----------------
Retrospective Study :Describe the Changes of the Disease in Many Cases Likely to Aggravate.

Conditions
-----------------
Congenital Myasthenic Syndrome

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Adult women Congenital myastenic syndrome genetically confirmed or with clinical compatible and electrophysiological evidence Written consent Exclusion Criteria: Neurological or general pathology occurs significantly with the initiation and conduct of a pregnancy.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Congenital Myasthenic Syndrome, Pregnancy, Outcome
Performing Fractional Flow Reserve Without Anticoagulation During Diagnostic Catheterization

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to assess the safety of performing fractional flow reserve (FFR) of the myocardium without using anticoagulation by performing a retrospective review of 100 consecutive patients who have undergone this procedure during diagnostic catheterization.

Detailed Description
-----------------
An experienced interventional cardiologist can perform FFR in a brief period of time. This procedure can safely be performed without anticoagulation, thereby lowering the associated procedural risks by avoiding the bleeding and groin complications that may occur with anticoagulation. Performing FFR without anticoagulation may also decrease facility costs as femoral artery closure can be performed using standard protocols for a diagnostic procedure, instead of standard protocols for an interventional procedure when a patient has been anticoagulated. Performing FFR without anticoagulation does not increase risk of injury to the coronary artery or thrombus in the coronary artery.

Official Title
-----------------
Retrospective Assessment of the Safety of Performing Fractional Flow Reserve (FFR) of the Myocardium Without Anticoagulation During Diagnostic Cardiac Catheterization

Conditions
-----------------
Coronary Artery Disease

Intervention / Treatment
-----------------
* Procedure: Fractional Flow Reserve


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with moderate stenosis who underwent FFR without anticoagulation Exclusion Criteria: Therapeutic anticoagulation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Fractional Flow Reserve<br>Patients with suspected coronary artery disease undergoing FFR to assess physiological significance of stenosis | Procedure: Fractional Flow Reserve<br>* Fractional Flow Reserve performed without anticoagulation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complications related to use of pressure wire |  | 0-30 days (index procedure) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complications due to FFR procedure |  | 0-30 days (index hospitalization) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Fractional Flow Reserve, Without anticoagulation
Therapy for Depressed Elders With Thought Problems

Study Overview
=================
Brief Summary
-----------------
This study will compare the effectiveness of Problem Solving Therapy and Brief Supportive Therapy in treating elderly patients with major depression and thought problems.

Detailed Description
-----------------
Patients who suffer from a combination of major depression and executive dysfunction symptoms often respond poorly to treatment with antidepressants. It is important, therefore, to find effective alternative therapies to treat these symptoms. Patients are randomly assigned to receive 12 sessions (1 session/week for 12 weeks) of either PST or BST. Following treatment, patients are followed for 6 months to determine functional and clinical outcomes. Depression scales, disability scales, and scales that measure problem solving skills are used to assess patients.

Official Title
-----------------
PST in Geriatric Depression With Executive Dysfunction

Conditions
-----------------
Depression, Cognition Disorders

Intervention / Treatment
-----------------
* Behavioral: Problem Solving Therapy
* Behavioral: Brief Supportive Therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Nonpsychotic, unipolar major depression Cognitive impairment English speaking Exclusion Criteria: High suicide risk Dementia Acute or severe medical illness Current psychotherapy

Ages Eligible for Study
-----------------
Minimum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1 Problem Solving Therapy<br>12 weekly sessions of problem solving therapy (PST) | Behavioral: Problem Solving Therapy<br>* A 12 week cognitive behavioral intervention for depression that teaches patients a structured approach to solving social problems.<br>|
| Experimental: 2 Brief Supportive Therapy<br>12 weekly sessions of brief supportive therapy (BST) | Behavioral: Brief Supportive Therapy<br>* A 12 week intervention for depression that focuses on supporting patients attempts to cope with depression.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hamilton Rating Scale for Depression |  | Measured at screening, weeks 1 through 12, and week 36 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Geriatrics
Indicators of Inflammation and Coagulation in Sepsis

Study Overview
=================
Brief Summary
-----------------
We will collect blood samples from patients with the diagnosis of sepsis and other ICU patients. We will describe the course of different mediator levels and organ injury markers and follow their progression throughout the course of the study.

Detailed Description
-----------------
After informed consent is obtained 5 cc of blood is collected on the day of admission and on days 0, 1, 3, and 7 thereafter. Plasma is collected and frozen for the subsequent measurement of biomarkers.

Official Title
-----------------
Temporal Behavior of Coagulation Factors, Cytokines and Tissue Injury Markers in Sepsis

Conditions
-----------------
Sepsis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Admission to the ICU Exclusion Criteria: No blood draws scheduled Hemoglobin level < 6,5 gm/dl

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sepsis<br>Patients with severe sepsis | |
| Non-infected<br>ICU patients without evidence of infection | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Death | Survival at 30 days | 30 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Sepsis, organ failure, cytokines, clotting factors
Haemodynamic Effect of Dexmedetomidine

Study Overview
=================
Brief Summary
-----------------
Dexmedetomidine, selective alfa2 receptors agonist produces sympatholysis. As a result heart rate decreases. With low doses blood pressure also decreases, with higher dosing - systematic vascular resistance increases. The indication for the drug is to produce sedation during surgical procedures and in ICU patients. The aim of a study is to verify, whether the haemodynamic effect (heart rate, blood pressure and heart rate variability during drug infusion) depend on pre-drug autonomic system activity. Autonomic system activity is assessed using heart rate variability (HRV)measurement before drug injection and during drug infusion. Heart rate and blood pressure measured before and during drug infusion will be analysed. HRV measurement analysis will be based on continuous Holter ECG recording, taken before drug injection and during its infusion. 5 minutes intervals will be analysed , using Frequency Domain Measures of HRV. Surgical procedure will start after measurement have been taken.

Official Title
-----------------
Haemodynamic Effect of Dexmedetomidine in Relation to Autonomic System Activity

Conditions
-----------------
Haemodynamic Effects of Dexmedetomidine

Intervention / Treatment
-----------------
* Drug: Dexmedetomidine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients classified with American Society of Anesthesiologists Physical Status Classification System as 1 or 2 status planned eye surgery under sedation Exclusion Criteria: patient's refusal contraindications to dexmedetomidine diseases/drugs that influence on autonomic nervous system activity

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Dexmedetomidine<br>Dexmedetomidine, 1 mcg/kg over 10 minutes, followed by a maintenance infusion, given to achieve sedation for eye surgery procedure | Drug: Dexmedetomidine<br>* 1 mcg/kg over 10 minutes, followed by a maintenance infusion titrated to achieve desired clinical effect - Richmond Agitation Scale between 0 and (-) 3. Holter ECG recording before start of infusion and during infusion for 25 minutes.<br>* Other names: Precedex;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of haemodynamics and heart rate variability parameters |  | up to 30 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
dexmedetomidine, heart rate, heart rate variability
Clinical Study on Implicit Learning, Comorbidity and Stress Vulnerability in Chronic Functional Pain

Study Overview
=================
Brief Summary
-----------------
The project investigates on the role of pain avoidance, comorbidity and stress response for the development of chronic somatic and visceral pain. We, the researchers at University Hospital Mannheim, assume that implicit operant learning of pain sensitization is a central mechanism of the process of pain becoming chronic, which is augmented by fear and by avoidance behaviour. Somatic and psychological comorbidity as well as stress factors are further promoting factors in chronic pain development.

Detailed Description
-----------------
Study 1: Implicit operant learning of sensitization and habituation in an experimental heat pain model will be investigated and compared in healthy controls, chronic pain patients with fibromyalgia, with and w/o visceral pain. Study 2: Functional imaging of implicit operant learning of sensitization and habituation in an experimental heat pain model (same subgroups as in study 1).

Official Title
-----------------
Implicit Learning, Comorbidity and Stress Vulnerability in Chronic Functional Pain Syndromes

Conditions
-----------------
Fibromyalgia, Irritable Bowel Syndrome

Intervention / Treatment
-----------------
* Behavioral: Experimental heat pain model


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Fibromyalgia according to American College of Rheumatology (ACR) criteria Visceral hypersensitivity according to ROME criteria Chronic pain according to International Association for the Study of Pain (IASP) criteria Exclusion Criteria: Abnormal quantitative sensory testing Psychiatric or neurological anamnesis, except fear and depression Acute major depression Substance abuse

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Experimental heat pain model|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Experimental study, chronic pain, operant learning, comorbidity, stress, Fibromyalgia w visceral hypersensitivity, Fibromyalgia w/o visceral hypersensitivity