Natriuretic Brain Pro-peptid Changes in Patients With Chronic Heart Failure Within a Cardiac Rehabilitation Program

Study Overview
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Brief Summary
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Evaluate pro-BNP levels, oxygen consumption, functional class, and quality of life in patients with chronic heart failure after participating in an exercise program and compare them baseline and 2 months, with another group who underwent an educational program.

Detailed Description
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Clinical controlled trial with a double blinded with a aleatory number sequence as the randomization method, patients will be assigned to one of two groups, intervention program (supervises exercise program) and control group (community based exercise)

Official Title
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Natriuretic Brain Pro-peptid (Pro-BNP)Changes in Patients With Chronic Heart Failure Enroled in a Controlled, Supervised Exercise Protocol Within a Cardiac Rehabilitation Program

Conditions
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Chronic Heart Failure

Intervention / Treatment
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* Other: controlled, supervised exercise protocol
* Other: exercise protocol no supervised


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients older than 18 years, diagnosed with heart failure (NYHA) II-IV for more than six months Exclusion Criteria: patients with NYHA functional class I, who had attended a cardiac rehabilitation program previously, patients with decompensated diabetes mellitus, hypertension difficult to control, ischemic heart disease in the last month, prior pulmonary embolism, chronic obstructive pulmonary disease, restrictive lung disease , aortic stenosis, new episode of atrial fibrillation and musculoskeletal diseases that limit the performance of physical activity

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: controlled, supervised exercise protocol<br>controlled, supervised exercise protocol within a cardiac rehabilitation program | Other: controlled, supervised exercise protocol<br>* exercise program within a cardiac rehabilitation program<br>|
| Placebo Comparator: community based exercise<br>educational program and not supervises exercise program | Other: exercise protocol no supervised<br>* Exercise program at the community<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Natriuretic Brain Pro-peptid |  | 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Oxygen Consumption |  | 8 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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chronic heart failure, cardiac rehabilitation, exercise, Natriuretic Brain Pro-peptid