General Anesthesia With and Without Muscle Relaxation and Muscle Strength Recovery

Study Overview
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Brief Summary
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Neuromuscular blocking agents are often used during general anesthesia. Also, general anesthesia may be performed without use of neuromuscular blocking agents. Avoiding neuromuscular relaxation enables better muscle strength recovery.

Detailed Description
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Rocuronium is well used neuromuscular blocking agent during general anesthesia. Although very often used, neuromuscular blocking agents may sometimes have consequence in form of residual neuromuscular block. Tha aim of the study is to compare influence of rocuronium during general anesthesia on muscle strength recovery measured by hand grip dynamometer. Measuremwnt of hand grip strength is perforrmed before and after general anesthesia. This research should contribute to better choice of anesthesia technique and better quality of patient recovery, as studies so far have not been detaily carried out. Hypothesis of the research is that anesthesia without use of neuromuscular blocking agents may enable better recovery of muscle strength in immediate postoperative period.

Official Title
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Comparison of General Anesthesia With Use of Muscle Relaxation and General Anesthesia Without Muscle Relaxation on Recovery of Muscle Strength of the Patients

Conditions
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Rocuronium, Muscle Weakness, General Anaesthesia

Intervention / Treatment
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* Drug: Rocuronium
* Procedure: General anesthesia for surgery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients ASA status I-III for surgery under general anesthesia signed informed consent for participating in research Exclusion Criteria: neuromuscular disease poorly controled chronic or acute cardiovascular, respiratory or autoimmune disease known allergic reaction to any medication used in this research pregnancy refusal to participate in this research

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Experimental group general anesthesia without rocuronium<br>30 patient ASA classification 1-2 for general anesthesia. Standard anesthesia monitoring. After induction with Propofol and Sufentanil ( doses adjusted according to weight and age) anesthesia was maintained with sevorane. Muscle strength measured on three occasions with Yamar dinamometar for hand grip strength, before induciran to anesthesia and immediate after Salingeru from anesthesia, then again measured in first 24 hours. | Procedure: General anesthesia for surgery<br>* General anesthesia with standard anesthetic monitoring,<br>* Other names: General anesthesia;|
| Active Comparator: Active comparator: general anesthesia with rocuronium<br>30 patient ASA classification 1-2 for general anesthesia. Standard anesthesia monitoring with train-of-four (TOF). After induction with Propofol and Sufentanil (doses adjusted according to weight and age) and rocuronium 0,6 mg per kg, anesthesia maintained with sevorane. Muscle strength neasured with Yamar dinamometar for hand grip strength before induction to anesthesia and immediate after awakening from anesthesia, then again measured in first 24 hours. | Drug: Rocuronium<br>* Rocuronium used for neuromuscular blokade during anesthesia and anesthesia without rocuronium<br>* Other names: Rocuronium bromide;Procedure: General anesthesia for surgery<br>* General anesthesia with standard anesthetic monitoring,<br>* Other names: General anesthesia;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle strenght recovery after general anesthesia | Change in muscle strength recovery measured with hand grip dynamometer after general anesthesia with or without rocuronium. Better understanding of mechanism how neuromuscular blockade influences quality if patient recovery due to muscle strength recovery | Perioperative | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Rocuronium, Muscle strength, Residual blockade