The HUNT for Heart Failure Risk Score

Study Overview
=================
Brief Summary
-----------------
In this population study aim is to evaluate risk factors for heart failure and combine these into a new heart failure risk score. Secondly, the heart failure risk score will be internally and externally validated, and compared with established heart failure risk scores. Additionally, the prevalence of heart failure as well as the distribution of the heart failure risk score in the general population will be evaluated.

Detailed Description
-----------------
Explore which clinical risk factors or patient characteristics in a general population that are associated with increased risk for heart failure events and combine these into a new population-based heart failure risk score (The HUNT for heart failure risk score) for predicting heart failure risk Validate the newly developed heart failure risk score internally in the HUNT2 database Compare the predictive ability of the new heart failure risk score with established heart failure risk scores (the ABC Health HF risk score, the Framingham HF risk score) and an established Norwegian cardiovascular risk score (NORRISK 2) Estimate the prevalence of likely (undiagnosed) heart failure , i.e., patients at high risk of HF, in a general population by using both the established heart failure risk scores and the newly developed heart failure risk score, and compare the heart failure event rate between those at high risk of heart failure and those with established heart failure.

Official Title
-----------------
Heart Failure Burden and Heart Failure Risk in the General Population in Norway: The HUNT for Heart Failure Risk Score

Conditions
-----------------
Heart Failure

Intervention / Treatment
-----------------
* Other: Heart failure risk estimation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Participation in the third or second wave of the HUNT study Exclusion Criteria: Not willing to participate Missing vital data

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Participants in the third wave of the HUNT study<br>General population participating in the third wave of the HUNT study | Other: Heart failure risk estimation<br>* Evaluation by heart failure risk score<br>|
| Participants in the second wave of the HUNT study<br>General population participating in the second wave of the HUNT study | Other: Heart failure risk estimation<br>* Evaluation by heart failure risk score<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to incident heart failure event | Time to first heart failure hospitalization or heart failure related visit at the out-patient clinic (events defined according to the ESC 2016 heart failure guidelines) | 10 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to death from any cause | Time to death from any cause | 10 years | 
| Time to first heart failure event or death from any cause | Time to first heart failure event (hospitalization or HF related visit at the out-patient clinic) or death from any cause | 10 years | 
| Validity of heart failure risk score | Evaluation of the validity of heart failure risk score | 10 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
risk factor, population, diagnosis, prognosis