Bone Marrow Adiposity and Fragility Fractures in Postmenopausal Women

Study Overview
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Brief Summary
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The purpose is to determine in a case-control study if an association exist between bone marrow adiposity and fragility fractures in post-menopausal women.

Official Title
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Bone Marrow Adiposity and Fragility Fractures in Postmenopausal Women: a Case-control Study

Conditions
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Fractures, Bone, Bone Marrow Disease, Fat Disorder, Adiposity

Intervention / Treatment
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* Device: Dixon Magnetic Resonance Imaging
* Device: dual-energy X-ray absorptiometry (DXA)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: post-menopausal women : 50-90 years old Group 1 (cases) : occurence of incident major osteoporotic fracture less than 12 months Group 2 (controls) : no history of fragility fracture Exclusion Criteria: Implants that are contraindicated for the magnetic resonance (MR) examination. Implants that might create a health risk or other problem during an MR exam include: 1) cardiac pacemaker or implantable defibrillator, 2) catheter that has metal components that may pose a risk of a burn injury, 3) a ferromagnetic metal clip placed to prevent bleeding from an intracranial aneurysm, 4) an implanted medication pump (such as that used to deliver insulin or a pain-relieving drug), and 5) a cochlear implant. body mass index [BMI] >38 kg/m2, weight >140 kg Disease or current use of medications known to affect bone density, including oral glucocorticoids, treatments for osteoporosis (bisphosphonates, raloxifene, calcitonin, or PTH), hormone therapy. Chronic kidney disease with DFG <30 ml/mn

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1 (cases)<br>occurence of incident major osteoporotic fracture less than 12 weeks | Device: Dixon Magnetic Resonance Imaging<br>* MRI of the lumbar spine (L1 to L4) and hip (non-dominant) for the measurement of Ad Med. (In%) by the DIXON sequence.<br>|
| Group 2 (controls)<br>no history of fragility fracture | Device: dual-energy X-ray absorptiometry (DXA)<br>* Subjects will undergo DXA scan to assess total body (less head) and lumbar spine bone mineral density.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bone marrow fat content at lumbar spine | Total bone marrow fat content (percentage) at lumbar spine (L1-L4) measured with magnetic resonance imaging | 24 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bone marrow fat content at total hip | Total bone marrow fat content (percentage) at total hip measured with magnetic resonance imaging | 24 months | 
| Bone mineral density at lumbar spine | Bone mineral density (g/cm2) at lumbar spine (L1-L4) measured by DXA | 24 months | 
| Bone mineral density at total hip | Bone mineral density (g/cm2) at total hip measured by DXA | 24 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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marrow adipose tissue, bone marrow adiposity