Risk Factors of Preterm Birth Born in Hospital：a Prospective Multicenter Case-control Study

Study Overview
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Brief Summary
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The purpose of this study is to explore the perinatal risk factors of preterm birth in China.

Detailed Description
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Preterm birth is a global scourge, and the leading cause of newborn deaths (babies in the first 4 weeks of life) and raised to the leading cause of death among children under 5 years of age, responsible for approximately 1 million deaths in 2015. In China, the prevalence of preterm increased from 4 5% in 1990s to 7 10% in 2010. Preterm birth become a burden to both the family and society. Therefore, the risk factors of preterm birth become the critical issue of both Obstetrics and Neonatology. More importantly, few multicenter prospective studies on risk factors of preterm birth included potential reasons such as maternal occupation, psychology condition and lifestyles during pregnancy were conducted in China. Thus, the aim of our study is to explore the perinatal risk factors of preterm birth nowadays in China.

Official Title
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Risk Factors of Preterm Birth Born in Hospital：a Prospective Multicenter Case-control Study

Conditions
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Risk Factors

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Live-born infants >20weeks of gestational age Exclusion Criteria: Stillbirth

Ages Eligible for Study
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Maximum Age: 28 Days

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Preterm group<br>All the live-born infants with gestational age less than 37weeks and more than 20weeks born in the cooperative hospital every day or every two or three days. | |
| Term group<br>The one next-live-born infants with gestational age at 37weeks or more than 37weeks. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| live-born preterm | less than 37weeks gestational age | at birth | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| birth weight (g) | Infant's weight recorded at the time of birth | at birth | 
| gestation age (week) | the number of completed weeks of gestation, which was determined by the duration of menorrhoea or confirmed by an early ultrasound scan during pregnancy | at birth | 
| Apgar score | determined by evaluating the newborn baby on five simple criteria（Appearance, Pulse, Grimace, Activity, Respiration） on a scale from zero to two, then summing up the five values thus obtained. The resulting Apgar score ranges from zero to 10. | 1min after birth | 
| Apgar score | determined by evaluating the newborn baby on five simple criteria（Appearance, Pulse, Grimace, Activity, Respiration） on a scale from zero to two, then summing up the five values thus obtained. The resulting Apgar score ranges from zero to 10. | 5min after birth | 
| small for gestational age | a birth weight below the 10th percentile for the gestational age | at birth | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Premature birth; Risk factors