Clinical Assessment of 3 Differant Obturation Sealers on Postoprative Pain and Swelling

Study Overview
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Brief Summary
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aim of the study will be conducted to compare the effect of MTA fill apex sealer and endo sequence bioceramic sealer in obturation on the intenisty of postoperative pain and the incidence of post operative swelling in patient with necrotic teeth .

Official Title
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Assessment of 3 Different Root Canal Obturating Sealers on Postoperative Pain and Swelling in Single Canal Necrotic Teeth With a Single Visit .a Randomized Controlled Trial

Conditions
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Necrotic Pulp, Single Root Teeth

Intervention / Treatment
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* Drug: bioceramic sealer
* Drug: MTA
* Drug: resin sealer


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients requiring root canal treatment of single canal necrotic teeth. Patient from 18 to 60 years old Patients with Asymptomatic apical periodontitis. Teeth presenting with no clinical symptoms and with a periapical score from 2 to 4 according to Orstavik et al Exclusion Criteria: Teeth with incompletely formed apex Teeth requiring retreatment Patients having complicating systemic disease such as diabetes, malignancy, pregnancy, central nervous system disorders, Cardiovascular system disorders, respiratory disorders, asthma patients, psychiatric disorders, immunocompromised patients Patients taking anti-inflammatory or antibiotics Patients giving history of analgesic or antibiotic intake 1 week before treatment Patients below 18 years of age Patients above 65 years of age Patients having history of peptic ulcer or gastrointestinal bleeding Teeth affected with periodontal disease

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: endo sequence bioceramic sealer<br>obturation using Endo-sequence BC sealer | Drug: bioceramic sealer<br>* bioceramic based obturating sealer<br>* Other names: endosequence;|
| Experimental: MTA fill apex calcium silicate base sealer<br>obturation using calcium-silicates based MTA fill-apex sealer | Drug: MTA<br>* MTA based obturating sealer<br>* Other names: MTA fill apex;|
| Experimental: AH plus resin sealer<br>obturation using AH Plus sealer | Drug: resin sealer<br>* resin based obturating sealer<br>* Other names: AH Plus resin sealer;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intensity of post-operative pain | Measurement of post-operative pain by Visual analogue scale | 6 hours | 
| Intensity of post-operative pain | Measurement of post-operative pain by Visual analogue scale | 12 hours | 
| Intensity of post-operative pain | Measurement of post-operative pain by Visual analogue scale | 24 hours | 
| Intensity of post-operative pain | Measurement of post-operative pain by Visual analogue scale | 48 hours | 
| Intensity of post-operative pain | Measurement of post-operative pain by Visual analogue scale | 72 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| post operative swelling | Yes or no yes or no | 24 hours |