linjc16/ctgov huggingface dataset:
Computed Tomography (CT)--An Epidemiologic Study in the Young

Study Overview
=================
Brief Summary
-----------------
To investigate the relationship between coronary heart disease risk factors and coronary artery calcification in middle age adults from the Muscatine Study. From 1992 through 1995, ultrafast computed tomography was used to measure coronary artery calcification. The study has been extended through January, 2001 in order to examine the role of electron beam computed tomography in detecting the presence and quantity of coronary artery calcification, a marker of the atherosclerotic process.

Detailed Description
-----------------
BACKGROUND: Atherosclerotic heart disease, a major cause of mortality and morbidity in the United States, has been shown to have its origins in childhood. Deposition of calcium occurring early in the atheromatous process is often observed in postmortem studies of coronary arteries and the aorta. Ultrafast computed tomography (Fast-CT) provides a highly sensitive, non-invasive technique for detecting the presence and quantity of coronary artery calcification (CAC). The 'risk factors' for coronary artery disease have been determined by measuring levels of potential factors in middle-and older-aged adults and determining which predict atherosclerotic cardiovascular disease, including coronary artery disease (CAD), peripheral vascular disease, and cerebrovascular disease. Adult subjects with CAC have a greater number of coronary risk factors, including higher cholesterols. In the age group of 30-39 years, 30 to 40 percent have radiographic evidence of coronary artery or aortic calcification. In the Muscatine Study, the investigators examined coronary risk factors in 2400 subjects during childhood (ages 9-11 years) and again in young adult life (ages 20 to 30 years). This population can now provide important information related to measures of childhood and young adult coronary risk factors predicting the development of the atherosclerotic process in adults in their fourth decade of life. DESIGN NARRATIVE: Beginning in 1992, the longitudinal study used the non-invasive technique of ultrafast computed tomography to examine the relationship of known coronary risk factors measured in childhood and again in early adult life in order to correlate their association with coronary artery calcification. Risk factors included lipids, lipoproteins, apolipoproteins, lipoprotein(a), apo(a) genotypes, homocyst(e)ine, and left ventricular mass. Beginning in February 1996, electron beam computed tomography is used to associate risk factors with coronary artery calcification.

Conditions
-----------------
Cardiovascular Diseases, Coronary Disease, Atherosclerosis, Heart Diseases

Participation Criteria
=================
Eligibility Criteria
-----------------
No eligibility criteria
Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
COMParison of Algorithms for Rotational Evaluation in Atrial Fibrillation

Study Overview
=================
Brief Summary
-----------------
This is a cohort study to evaluate algorithms for mapping atrial fibrillation by mapping atrial structure and mapping electrical activity to detect focal and rotational activity.

Detailed Description
-----------------
In this study, the investigators will compare mapping approaches for atrial fibrillation ablation. First, investigators will compare approaches to map atrial structure from collected computed tomography (CT) scans or magnetic resonance imaging (MRI) scans acquired routinely in patients undergoing ablation for atrial fibrillation. Imaging will be acquired from a variety of clinically approved Second, investigators will compare approaches to analyze electrograms collected routinely at clinical electrophysiology study (EPS) in patients undergoing ablation for atrial fibrillation. Electrograms will be recorded from a variety of clinically approved catheters under standard of care conditions, and will be analyzed to better understand the mechanisms for atrial fibrillation and its relationship to outcomes. The investigators anticipate analyzing data from 200 patients through December 2017.

Official Title
-----------------
COMParison of Algorithms for Rotational Evaluation in Atrial Fibrillation

Conditions
-----------------
Atrial Fibrillation, Abnormal Heart Rhythms

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: aged 21-80 yrs who underwent electrophysiology study for ablation of Atrial Fibrillation Exclusion Criteria: Poor data quality of recordings of AF

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnostic Accuracy | Comparing mapping systems to diagnose sites of importance in Atrial Fibrillation | At the time of procedure | 
| Diagnostic Accuracy | Comparing algorithms to segment atrial structures from computed tomography or Magnetic resonance images. | At time of procedure. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analysis Time | Comparing time required to segment atrial structures from computed tomography or magnetic resonance images. | At time of procedure. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
abnormal heart rhythm, atrial fibrillation, ablation
Time-restricted Feeding to Reduce Inflammation in Fanconi Anemia

Study Overview
=================
Brief Summary
-----------------
The main reason for this research study is to determine whether time-restricted eating will reduce inflammation in the bodies of persons with Fanconi anemia (FA) and whether time-restricted eating will improve function in people with FA and neurological changes. Participants will be asked to eat for only 8 hours out of 24 hours in a day.

Official Title
-----------------
Single Arm Prospective Trial of Time-restricted Feeding to Reduce Inflammation in Fanconi Anemia

Conditions
-----------------
Fanconi Anemia

Intervention / Treatment
-----------------
* Behavioral: Time-Restricted Feeding


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of FA with neuroinflammation Age ≥ 12 years old Exclusion Criteria: None

Ages Eligible for Study
-----------------
Minimum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Time-Restricted Feeding<br> | Behavioral: Time-Restricted Feeding<br>* Participants will be asked to eat for only 8 hours out of 24 hours in a day.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of participants with neuroinflammation | Presence of neuroinflammation will be measured with a clinical head MRI | 6 months |
Dermacyd PH_DESILSTY_FR (Lactic Acid) - Acceptability - Stay on Frutal

Study Overview
=================
Brief Summary
-----------------
Primary Objective: To prove the safety of the gynecological formulation in normal conditions of use.

Official Title
-----------------
Monocentric Study, Phase III, for Safety Dermatological Evaluation: Acceptability With Gynaecological Follow up - Dermacyd PH_DESILSTY_FR (Lactic Acid).

Conditions
-----------------
Hygiene

Intervention / Treatment
-----------------
* Drug: LACTIC ACID(ND)


Participation Criteria
=================
Eligibility Criteria
-----------------
Exclusion criteria: Integral vaginal mucosa in the product analysis region Use the same category of cosmetics products Willingness in following the study procedures and to be present in the clinic at the days and scheduled time Exclusion criteria: Use of Anti-inflammatory, immunossupression or antihistaminics drugs Allergic or atopic history to cosmetics products Cutaneous active disease (local and/or general) in the evaluated area Disease which can cause immunosuppresion, such as diabetes, HIV Endocrinology pathology such as thyroid gland, ovary and adrenal gland Intensive solar exposure until 15 days before evaluation Gynecological treatment until four weeks before the study Other reason considered by the investigator as a reason for not being included. The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Dermacyd PH_DESILSTY_FR (Lactic Acid)<br>Treatment duration: 21 consecutive days | Drug: LACTIC ACID(ND)<br>* Treatment duration: 21 consecutive days<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of the absence of irritation and the good acceptability by using one specific scale which describes the intensity of the reaction. |  | From the treatment start up to the end of the study (treatment period 21 days) |
Early Exposure of Medical Students to Night Shifts: Impact on Well-being and Anxiety

Study Overview
=================
Brief Summary
-----------------
This is an interventional study assessing the impact of 'shadowing night shifts' early during medical school, on the wellbeing and level of anxiety of a students during their first official night shifts.

Official Title
-----------------
Early Exposure of Medical Students to Night Shifts: Impact on Well-being and Anxiety

Conditions
-----------------
Medical Students Well-being and Anxiety

Intervention / Treatment
-----------------
* Other: Night shift shadowing program


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Students of the class of 2021 at the Faculty of Medicine of Saint Joseph University in their fifth year (Med 2). Exclusion Criteria: student who has already been on call during internships in Lebanon or abroad, as well as students in other medical years.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Night shift shadowing program<br>Medical students who participated in a night shift shadowing program prior to their first official night shifts | Other: Night shift shadowing program<br>* Our population, made up of 70 students, was divided into two randomly randomized groups: 31 (44.3%) had five night shift shadowing duty prior to their first official night shifts, and 39 (55.7%) did not participate in the shadowing program.<br>|
| No Intervention: No night shift shadowing program<br>Medical students who did not participate in the night shift shadowing program prior to their first official night shifts | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Questionnaire | After the shadowing program is completed, both groups of medical students (those who participated in the shadowing program and those who did not), have to fill a questionnaire that assesses their wellbeing and level of anxiety regarding their first official night shifts. Our primary outcome is to evaluate the impact of the shadowing program on medical students well-being and their level of anxiety. | 6 months |
Comparing Dexmedetomidine With Bupivacaine Versus Bupivacaine Alone for Caudal Block in Supra - Umbilical Surgeries

Study Overview
=================
Brief Summary
-----------------
dexmedetomidine is an alpha 2 adrenergic receptor agonist that is given either systemically or combined to local anesthetics during regional blocks. Investigators studied the combination of dexmedetomedine/bupivacaine versus bupivacaine alone for caudal blockage in pediatric patients undergoing supra - umbilical surgeries.

Detailed Description
-----------------
Dexmedetomidine was combined to bupivavaine and administered via caudal route to be compared to caudal bupivavaine alone for analgesia following upper trunk surgery

Official Title
-----------------
Adding Dexmedetomidine to Caudal Bupivacaine for Analgesia in Supra - Umbilical Pediatric Surgeries: Would it Add More Analgesia

Conditions
-----------------
Anesthesia

Intervention / Treatment
-----------------
* Drug: Dexmedetomidine
* Drug: Bupivacaine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: supra - umbilical surgeries Exclusion Criteria: allergy to the drug or coagulopathy

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 6 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: D group<br>Dexmedetomidine with bupivacaine group Caudal dexmedetomidine 1.5 microgram/kg with bupivavaine (0.25%) 1.25 ml/kg were administered | Drug: Dexmedetomidine<br>* Caudal block by dexmedetomidine and bupivavaine<br>* Other names: Precedex;|
| Active Comparator: B group<br>Bupivacaine only group Caudal bupivavaine (0.25%) 1.25 ml/kg without dexmedetomidine was administered | Drug: Bupivacaine<br>* Caudal block by bupivavaine alone<br>* Other names: Marcaine;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain relief | CHEOPS scale value | 6 months study |
Prevalence and Environmental Factors for Myopia Among Chinese School-aged Children and Adolescent in Tianjin

Study Overview
=================
Brief Summary
-----------------
The high prevalence of myopia has become a global public health problem. The study amied to investigate the prevalence and progression of myopia associated with social environmental factors in Tianjin, a Chinese megacity in north China.

Detailed Description
-----------------
The high prevalence of myopia has become a global public health problem, especially in East and South Asian countries. It's still not clear for the prevalence and progression of myopia associated with social environmental factors. Thus, the investigators will conducted a long-term observational study to the effect of the socioeconomics, medical resources and school-related environmental parameters and others on the prevalence and progression of myopia among Chinese school-aged children and adolescent.

Official Title
-----------------
Prevalence and Environmental Factors for Myopia Among Chinese School-aged Children and Adolescent in Tianjin

Conditions
-----------------
Myopia, Refractive Errors

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: aged 6 to 18 years no ocular diseases and systemic diseases consent to undergo an eye examination Exclusion Criteria: schoolchildren unwilling to participate

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of myopia | Myopia is defined as any eye's SER (sphere + 1/2 cylinder) of at least -0.5 diopters (D). | up to 3years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in prevalence of myopia | Myopia is defined as any eye's SER (sphere + 1/2 cylinder) of at least -0.5 diopters (D). | up to 3years | 
| Changes of Spherical equivalent | Changes of Spherical equivalent | changes from baseline at 36months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Myopia, Socioeconomics
Corona-Like Illness: Did we Got it Before WHO Announcement of the Disease?

Study Overview
=================
Brief Summary
-----------------
A pneumonia of unknown cause detected in Wuhan, China was first reported to the WHO Country Office in China on 31 December 2019. The outbreak was declared a Public Health Emergency of International Concern on 30 January 2020. The spread and severity of the disease is variable from one country to another. Our team as well as many reports suggested that in some countries a  Flu like illness but much worse was described in October, November and early in December before the WHO announcement. Was it COVID-19?

Official Title
-----------------
COVID-19-Like Illness: Did we Have Unusual Severe Respiratory Tract Infections October-December 2019 Before WHO Announcement ?

Conditions
-----------------
COVID-19

Intervention / Treatment
-----------------
* Other: Questionnaire
* Diagnostic Test: IgG


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All subject except excluded group Exclusion Criteria: subject diagnosed as COVID-19 positive and their contacts

Ages Eligible for Study
-----------------
Minimum Age: 8 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Questionnaire|Survey to identify number of people who got unusual severe flu- like illness in last October- November|
|Diagnostic Test: IgG|Measure the past immunity of the disease (if possible)|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measure frequency of people suffered from unusual flu-like symptoms before December 2019 | fever, dry cough, dyspnea, malaise, headache | one month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measure remote immunity for COVID-19 in subject with past history of severe flu before WHO announcement date- if possible | serum IgG | 3 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
COVID-19, Corona-like illness, WHO announcement, Survey, IgG
Free-Living Physical Activity and Energy Expenditure

Study Overview
=================
Brief Summary
-----------------
We have recently validated a new device for measurement of physical activity and found it to detect type, duration and intensity of many types of physical activity at better than 98% accuracy. After further validating this device to determine if it can also accurately assess energy expenditure, we will use it to collect cross-sectional data on free-living physical activity and energy expenditure in adolescent girls.

Conditions
-----------------
Obesity

Participation Criteria
=================
Eligibility Criteria
-----------------
Study3: healthy lean and obese adults, at least 18 years of age.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Machine Learning for Recurrence Risk of Pancreatic Cancer After Radical Resection

Study Overview
=================
Brief Summary
-----------------
Recurrence of Pancreatic Cancer(PCa) is a multifactorial event. Based on the clinicopathological characteristics and imaging data of patients with PCa, the investigators used image processing and machine learning algorithms to build a more comprehensive and robust model, and added some unused features to explore its clinical application value. A retrospective analysis of patients with PCa who underwent radical resection at Zhejiang Cancer Hospital (Hangzhou, China) from January 2013 to December 2020. The database was extracted from the preoperative demographics, blood markers, and surgical pathology information of patients undergoing radical PCa surgery in the investigators' hospital. The investigators used the PyRadiomics platform to extract image features.

Official Title
-----------------
Multimodal Data Prediction Based on Machine Learning for Recurrence Risk of Pancreatic Cancer After Radical Resection

Conditions
-----------------
Pancreatic Cancer

Intervention / Treatment
-----------------
* Other: preoperative demographics, blood markers, surgical pathology information，and enhanced CT features.


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Have the results of enhanced CT examination of the pancreas within 1 month before surgery in our hospital; Radical resection of pancreatic cancer was performed in our hospital; There are follow-up results in our hospital, and the follow-up endpoints include disease recurrence or at least 12 months. Complete clinical medical records and imaging data. Exclusion Criteria: non-R0 resection; Combined with other malignant tumors The patient's imaging data has technical problems or the lesion is too small (less than 1cm), which is not suitable for omics analysis.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| postoperative recurrence<br> | Other: preoperative demographics, blood markers, surgical pathology information，and enhanced CT features.<br>* preoperative demographics, blood markers, surgical pathology information，and enhanced CT features.<br>|
| postoperative non-recurrence<br> | Other: preoperative demographics, blood markers, surgical pathology information，and enhanced CT features.<br>* preoperative demographics, blood markers, surgical pathology information，and enhanced CT features.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recurrence-free survival |  | 1 year |