Airway Inflammation, Symptoms and Lung Function in COPD

Study Overview
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Brief Summary
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Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease with high prevalence worldwide and with relevant impact on patient-related quality of life, morbidity and mortality. There is evidence that airway inflammation correlates with the severity of the disease and that airway inflammation is further enhanced during exacerbation. However, it is unknown whether daily fluctuation of symptoms or changes in lung function is paralleled by changes in airway inflammation.

Detailed Description
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Patients will undergo a visit every 7 days during one month (5 visits in total). At each visit airway inflammation (exhaled NO, sputum inflammatory cell count) and lung function will be performed. At home patients will be asked to fill a daily diary for symptom assessment.

Official Title
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Correlations Between Airway Inflammation, Symptoms and Lung Functions in Patients With Stable Chronic Obstructive Pulmonary Disease (COPD)

Conditions
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Chronic Obstructive Pulmonary Disease

Intervention / Treatment
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* Other: COPD treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Post-bronchodilator FEV1/FVC ratio < 70% Post-bronchodilator FEV1 < 80% Smokers or ex-smoker with pack/years > 15 Exclusion Criteria: Atopy Asthma Concomitant lung diseases (e.g. lung cancer) Acute infections of the respiratory tree in the previous 2 months including COPD exacerbation.

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COPD<br> | Other: COPD treatment<br>* Patients, will be asked to continue their previous medication (GOLD guidelines) during the study. No interventional change in COPD treatment will be performed during the study.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between changes in airway inflammation and symptom score | Correlation between changes in airway inflammation and symptom score will be evaluated | 1 month, | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between changes in airway inflammation and lung function | Correlation between changes in airway inflammation and lung function will be evaluated | 1 month | 
| Correlations between airway inflammation and symptom scores | Correlation between markers of airway inflammation and symptom score will be performed | 1 month | 
| Correlations between airway inflammation and lung function | Correlation between markers of airway inflammation and lung function will be assessed | 1 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COPD, Airway inflammation, Symptoms, Lung function, Correlation