The Cognitive and Cerebral Blood Flow Effects of Resveratrol

Study Overview
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Brief Summary
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Research shows that resveratrol is able to induce vasodilation (and therefore blood flow) by interacting with nitric oxide (NO). Research also shows that acute administration of metabolic substrates, like oxygen and glucose, can enhance aspects of cognitive performance in young, healthy humans. The aim of this investigation was to determine if the consumption of resveratrol could modulate cerebral blood flow and if this in turn could influence cognitive performance by increasing access to blood borne metabolic fuel. Results showed that compared to placebo, after consuming 500mg pure trans-resveratrol, levels of total haemoglobin were significantly higher in the frontal cortex of young, healthy participants during cognitive task completion. Cognitive performance was not effected.

Official Title
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Effects of Resveratrol on Cerebral Blood Flow Parameters and Cognitive Performance in Humans: a Double-blind, Placebo-controlled, Crossover Investigation

Conditions
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Cognitive and Cerebral Blood Flow Effects of Resveratrol

Intervention / Treatment
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* Dietary Supplement: Trans- resveratrol
* Other: Placebo (silica)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male/female, Healthy Age 18-35 years old Non smoker Proficient in English Not taking any herbal or prescription medications Not pregnant Does not drink more than 6 cups of coffee per day Exclusion Criteria: Suffered a head injury, neurological disorder or neuro-developmental disorder Food allergies/intolerances

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Resveratrol 250mg<br> | Dietary Supplement: Trans- resveratrol<br>* All 24 participants who completed the study took part in 3 conditions; receiving either 250mg resveratrol, 500mg resveratrol or placebo on separate days (with a 48hr-14day wash out period between each treatment) with the order dictated by a latin square. Treatment was administered in capsule form and in a double blind manner.<br>* Other names: Transmax from Biotivia.;Other: Placebo (silica)<br>* All 24 participants who completed the study took part in 3 conditions; receiving either 250mg resveratrol, 500mg resveratrol or placebo on separate days (with a 48hr-14day wash out period between each treatment) with the order dictated by a latin square. Treatment was administered in capsule form and in a double blind manner.<br>* Other names: Pharmaceutical grade silica;|
| Experimental: Resveratrol 500mg<br> | Dietary Supplement: Trans- resveratrol<br>* All 24 participants who completed the study took part in 3 conditions; receiving either 250mg resveratrol, 500mg resveratrol or placebo on separate days (with a 48hr-14day wash out period between each treatment) with the order dictated by a latin square. Treatment was administered in capsule form and in a double blind manner.<br>* Other names: Transmax from Biotivia.;Other: Placebo (silica)<br>* All 24 participants who completed the study took part in 3 conditions; receiving either 250mg resveratrol, 500mg resveratrol or placebo on separate days (with a 48hr-14day wash out period between each treatment) with the order dictated by a latin square. Treatment was administered in capsule form and in a double blind manner.<br>* Other names: Pharmaceutical grade silica;|
| Placebo Comparator: Placebo<br> | Dietary Supplement: Trans- resveratrol<br>* All 24 participants who completed the study took part in 3 conditions; receiving either 250mg resveratrol, 500mg resveratrol or placebo on separate days (with a 48hr-14day wash out period between each treatment) with the order dictated by a latin square. Treatment was administered in capsule form and in a double blind manner.<br>* Other names: Transmax from Biotivia.;Other: Placebo (silica)<br>* All 24 participants who completed the study took part in 3 conditions; receiving either 250mg resveratrol, 500mg resveratrol or placebo on separate days (with a 48hr-14day wash out period between each treatment) with the order dictated by a latin square. Treatment was administered in capsule form and in a double blind manner.<br>* Other names: Pharmaceutical grade silica;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Modulation of Levels of Total Haemoglobin | This outcome measure provides the change from baseline values (in µmol/L) of total levels of haemoglobin during the 46-81 min post dose testing period. This was measured in the frontal cortex by near infrared spectroscopy (NIRS). | 0-81 mins (absorption period=1- 45 mins , post dose period 46- 81 mins) | 
| Modulation of Deoxygenated Levels of Haemoglobin | This outcome measure provides the change from baseline values (in µmol/L) of levels of deoxygenated haemoglobin during the 46-81 min post dose testing period. This was measured in the frontal cortex by near infrared spectroscopy (NIRS). | 0-81 mins (absorption period=1- 45 mins , post dose period 46- 81 mins) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants With Significant Modulation of Cognitive Performance | This outcome measure assessed any significant modulation of cognitive task performance during the 46-81 min post dose period. The cognitive tasks utilized were cognitively demanding computer based, numerical tasks which assessed working memory. Significant modulation is defined as significant difference between baseline and post-dose task performance. | 46-81 mins post dose | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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resveratrol, cerebral blood flow, NIRS, cognitive performance