Esophageal Absorption in EoE

Study Overview
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Brief Summary
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To determine how the esophagus in active and inactive stages of eosinophilic esophagitis tranmit fluids.

Official Title
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Esophageal Absorption in Eosinophilic Esophagitis

Conditions
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Eosinophilic Esophagitis

Intervention / Treatment
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* Other: D-xylose


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients between the ages of 18 and 80 with eosinophilic esophagitis diagnosed by a combination of compatible symptoms, endoscopic findings, histology, and lack of response to proton pump inhibitors or negative pH study endoscopy with esophageal and duodenal biopsies within two weeks of performance of this study Patients between the ages of 18 and 80 with eosinophilic esophagitis diagnosed by a combination of compatible symptoms, endoscopic findings, histology, and lack of response to proton pump inhibitors or negative pH study, and are now in histologic remission( <15phf) by the use of steroids or the six food elimination diet. Volunteers will be selected for not having any history of esophageal symptoms Exclusion Criteria: Vulnerable populations, such as those with diminished mental acuity, will be excluded. Patients taking Nsaids within 48 hours of the d-xylose testing artificial sweeteners within 48 hours of the d-xylose testing History of IBD Currently smoking or history of smoking History of Celiac disease Bacterial overgrowth, motility disorders other diffuse small bowel diseases.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: D-xylose, water, honey<br>25 grams of D-xylose 10 cc of water 2 teaspoons of honey | Other: D-xylose<br>* There will be four patient groups analyzed. Ten patients each, 10 with active eosinophilic esophagitis defined by consensus guidelines, 20 patients in histologic remission (10 by steroids and 10 by diet) and 10 control volunteers will be studied. Patients who have consented to the trial will be scheduled at the Clinical Research Unit (CRU) Patients will report to Charlton 7 the CRU, having their height, weight, blood pressure and temperature recorded. Subjects can choose to either have a saline lock IV placed or have their bloods drawn 3 separate times. They will receive 25 grams of D-xylose orally. The D-xylose will be mixed in 10 cc of water with 2 teaspoons of honey. D-xylose serum levels will be drawn at 5 and 10 and 60 minutes.<br>* Other names: Absorption study;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reliability of the d-xylose testing defined by the serum levels | D-xylose serum levels will be drawn at 5 and 10 and 60 minutes. D-xylose levels will be compared between the patients with active EOE and healthy controls using the Wilcoxon rank sum test. | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| D-xylose testing compared to endoscopy/biopsy findings. | Histologic parameters will include grading of spongiosis as an indicator of dilated intercellular spaces which will be correlated to serum levels of D-xylose. | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Eosinophilic Esophagitis, EoE, dysphagia