linjc16/ctgov huggingface dataset:
Effect of Increased Oxygenation in the Air During Endurance Training in Stable Angina Pectoris Patients

Study Overview
=================
Brief Summary
-----------------
The study investigates whether endurance training breathing 100% oxygen gives a additional improvement of maximal oxygen uptake in stable Angina Pectoris patients, compared to training without extra oxygen supplementation. In addition work economy, stroke volume and cardiac perfusion is measured. The hypothesis of the study is that increased oxygenation of the air increases performance, stroke volume, work economy and cardiac perfusion.

Official Title
-----------------
Effect of Increased Oxygenation in the Air During Endurance Training in Stable Angina Pectoris Patients

Conditions
-----------------
Angina Pectoris

Intervention / Treatment
-----------------
* Behavioral: Hypoxic interval training
* Behavioral: Normoxic interval training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: stable angina pectoris age 18-75 Exclusion Criteria: unstable angina pectoris Limitations to exercise other than coronary artery disease Participants in other study interventions

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Hypoxic Interval training<br>4 x 4 minutes interval training with 100% oxygenated air | Behavioral: Hypoxic interval training<br>* 4 x 4 minutes interval training in hypoxic air, 3 times per week at 90-95% HR max<br>|
| Experimental: Normoxic interval training<br>4 x 4 minutes interval training in normoxic air | Behavioral: Normoxic interval training<br>* 4 x 4 minutes normoxic interval training, 3 times per week at 90-95% HR max<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| maximal oxygen uptake |  | Baseline and post training | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiac perfusion |  | Baseline and post training | 
| work economy |  | Baseline and post training | 
| cardiac output |  | baseline and post training | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
angina pectoris, hyperoxia, endurance training, stroke volume, cardiac perfusion
Virological Suppression in HIV Positive Patients Involved in a Novel Standardized Adherence Protocol

Study Overview
=================
Brief Summary
-----------------
This study will look at virologically suppression of patients with HIV who receive pharmacist or case management care.

Official Title
-----------------
Virological Suppression in HIV Positive Patients Involved in a Novel, Standardized Adherence Protocol

Conditions
-----------------
Hiv

Intervention / Treatment
-----------------
* Other: Service of care


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with a baseline viral load > 200 copies/ml Patients who agree to program enrollment Patients ≥ 18 years of age Exclusion Criteria: Pregnant women Adults unable to consent Prisoners

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Pharmacy<br>service of care: pharmacy | Other: Service of care<br>* Subjects will be receiving care from case management or clinical pharmacy.<br>|
| Active Comparator: Case management<br>service of care: case management | Other: Service of care<br>* Subjects will be receiving care from case management or clinical pharmacy.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of virological suppression |  | 6 months |
Biomechanical Analysis of Different Landing Manoevres

Study Overview
=================
Brief Summary
-----------------
In this study, three-dimensional biomechanics , by means of lower limb joint angles and moments (opto-electronic system with synchronised force plate), of different landing manoevres will be compared in a population of basketball and volleyball players.

Detailed Description
-----------------
In this study, three-dimensional biomechanics , by means of lower limb joint angles and moments (opto-electronic system with synchronised force plate), of different landing manoevres will be compared in a population of basketball and volleyball players. General as well as more sport-specific jumps will be performed in this study.

Official Title
-----------------
Biomechanical Analysis of Different Landing Manoevres in Volleyball and Basketball Players

Conditions
-----------------
Landing Biomechanics

Intervention / Treatment
-----------------
* Other: 3D analysis of different landing tasks


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: volleyball and basketball players male Exclusion Criteria: history or surgery of the lower extremities history of fractures of the lower extremities

Ages Eligible for Study
-----------------
Minimum Age: 16 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy basketball or volleyball players<br>Basketball and volleyball players Landing biomechanics of different landing tasks is investigated in a population of volleyball and basketball players | Other: 3D analysis of different landing tasks<br>* General as well as more sport-specific landing tasks are investigated with 3D analysis by using an opto-electronic system<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| External knee joint moments | Knee joint moments will be extracted with an opto-electronic system and synchronised force plate | comparison between 2 different test moments separated by one week | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
landing, biomechanics
Attitude and Perception Towards COVID-19 Pandemic

Study Overview
=================
Brief Summary
-----------------
Assess response and attitude of general population living in Sharkia Governerate, Egypt as regard COVID-19 pandemic through arabic questionnaire.

Official Title
-----------------
Attitude and Perception of General Population in Sharkia Governerate Towards COVID-19 Pandemic

Conditions
-----------------
COVID-19

Intervention / Treatment
-----------------
* Other: questionnaire


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: General population within age range (16-70) and both sexes living in Sharkia Governerate, Egypt and accept to participate Exclusion Criteria: below 16 or above 70 years refuse to participate duplicate answers incomplete answers

Ages Eligible for Study
-----------------
Minimum Age: 16 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: questionnaire|Arabic questionnaire focused on knowledge, perception and attitude|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Knowledge about COVID-19 by questionnaire |  | 30 days after enrollment | 
| Perception about COVID-19 by questionnaire |  | 30 days after enrollment | 
| Attitude towards COVID-19 by questionnaire |  | 30 days after enrollment |
Enzyme Activity of Matrix Metalloproteinases in the Serum of Patients With Malignant Obstructive Hyperbilirubinemia Before and After PTBD

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to detect differences in the enzymatic activity of matrix metalloproteinases in patients with malignant obstructive hyperbilirubinemia before and after percutaneous biliary drainage.

Detailed Description
-----------------
This study will be designed as a prospective cohort study involving the collection of peripheral blood samples before and one month after percutaneous biliary drainage for further molecular biochemical analysis (measurement of serum matrix metalloproteinase activity). Biochemical analyzes are preceded by the entry of data relevant to the research (demographic, anamnestic, clinical and biochemical).

Official Title
-----------------
Influence of Percutaneous Biliary Drainage on the Change of Enzyme Activity of Matrix Metalloproteinases in the Serum of Patients With Malignant Obstructive Hyperbilirubinemia

Conditions
-----------------
Matrix Metalloproteinase

Intervention / Treatment
-----------------
* Procedure: Percutaneous biliary drainage


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: pathological confirmation or imaging data confirming malignant disease causing bile duct obstruction, performance status 0-1 Exclusion Criteria: terminally ill patients, performance status >2, hepatic decompensation, severe underlying cardiac or renal diseases and coagulation disorders.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Matrix Metalloproteinases<br>Value of serum matrix metalloproteinase activity before and one month after PTBD | Procedure: Percutaneous biliary drainage<br>* Collection of peripheral blood samples before and one month after percutaneous biliary drainage performed for patients with malignant obstructive hyperbilirubinemia for further molecular biochemical analysis (measurement of serum matrix metalloproteinase activity).<br>* Other names: Matrix Metalloproteinase serum activity measurement;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MMP-2 and MMP-9 serum activity | MMP serume activity will be measured by molecular biochemical analysis performed on peripheral blood samples taken before and one month after percutaneous biliary drainage | during intervention | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
biliary drainage, matrix metalloproteinases
Radical Prostatectomy and Perioperative Fluid Therapy

Study Overview
=================
Brief Summary
-----------------
The optimal amount of fluid a patient need under surgery is not clear. Both to much and to little fluid can damage the organ functions. A strategy called Goal directed therapy, where the fluid amount a patient need is guided by the stroke volume, has shown to minimize post-operative nausea and vomiting. The investigators intend to investigate if patients treated after these standards, has a better outcome then patients treated after normal regimes, regarding post-operative orthostatic-intolerance.

Official Title
-----------------
Radical Prostatectomy and Perioperative Fluid Therapy

Conditions
-----------------
Prostate Cancer

Intervention / Treatment
-----------------
* Procedure: Standard therapy
* Procedure: Maximization of cardiac stroke volume with fluid infusion


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with cancer in there prostate Exclusion Criteria: Patients who don't understand the information ASA > III Patients that are under treatment with the drug triazolam Patients with af known renal decease Patients with a psychiatric decease Alcohol abuse Severe haemorrhagic decease Cancer in the mouth,pharynx, larynx or oesophagus

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Standard treatment<br> | Procedure: Standard therapy<br>* Standard therapy<br>|
| Active Comparator: SV maximization<br> | Procedure: Maximization of cardiac stroke volume with fluid infusion<br>* Maximization of cardiac stroke volume with fluid infusion<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To investigate orthostatic cardiovascular response and orthostatic intolerance in patients after removal of the prostate |  | 6 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Investigate intraoperative haemodynamics |  | Intraoperative | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
patients with cancer in the prostate
Sequential Treatment of Hepatocellular Carcinoma by Transarterial Chemoembolization and Local Ablation or External Radiation

Study Overview
=================
Brief Summary
-----------------
Hepatocellular carcinoma (HCC) can present itself in many forms (size, number of lesions) for the treatment of which a therapeutic panel can be elaborated and layered. If a curative treatment cannot be considered in case of an HCC classified in an intermediate stage, a Transcatheter Arterial Chemoembolization (TACE) can be proposed. In case of a partial response or the treatment of some lesions of a multifocal HCC, a combined treatment by stereotaxic radiotherapy (CK), radiofrequency ablation (RFA) or microwave ablation (MWA) may be initiated in accordance with a decision of the multidisciplinary consultation meeting. The aim of this study was to evaluate the clinical outcome of HCC receiving MWA, RFA or CK after downstaging with TACE.

Official Title
-----------------
Sequential Treatment of Hepatocellular Carcinoma by Transarterial Chemoembolization and Local Ablation or External Radiation

Conditions
-----------------
Hepatocellular Carcinoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: a HCC treated by TACE followed by RFA, MWA and/or CK from 01/2010 to 12/2020 treated by Nancy Regional University Hospital (TACE, RFA, MWA) and Institut de Cancérologie de Lorraine (CK) Exclusion Criteria: Combined treatment over one year following the last TACE No baseline, in between or after combined treatment imaging Lesion appeared after TACE treatment

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lesion Response | Lesion response after combined treatment | 4-6 weeks after BWA or RFA or 3-6 months after CK | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Delayed Lesion Response | Lesion response a year after combined treatment | 1 year after BWA, RFA or CK | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hepatocellular Carcinoma, Transarterial Chemoembolization, Stereotactic body radiotherapy, Radiofrequency Ablation, Microwave Ablation
Atrial Fibrillation and By-pass Surgery

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to evaluate whether combined therapy with beta-blocker, amiodarone and statine is better than beta-blocker alone for the prevention of atrial fibrillation after coronary by-pass surgery.

Official Title
-----------------
Pharmacologic Prophylaxis for Atrial Fibrillation Following Coronary By-Pass Surgery

Conditions
-----------------
Patients With Coronary Artery Disease Scheduled for by Pass Surgery

Intervention / Treatment
-----------------
* Drug: Amiodarone tab 200 mg x 3
* Drug: rosuvastatin 20 mg tab x1
* Drug: beta blockers Bisoprolol in adjusted dose


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: significant coronary disease, sinus rhythm Exclusion Criteria: valvular disease, former by-pass surgery
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: beta blocker and amiodarone<br>The inteventin will be that patients will receive beta blocker Bisoprolol in adjusted dose + Amiodarone per os starting 7 days before coronary by-pass surgery, 200 mg. x 3 tab, followed by 200 mg x 2 tab per os starting on the second postoperative day untill discharge | Drug: Amiodarone tab 200 mg x 3<br>* starting 7 days before coronary by-pass surgery per os 200 mg. x 3 tab, followed by 200 mg x 2 tab per os starting on the second postoperative day untill discharge<br>* Other names: cordarone;Drug: beta blockers Bisoprolol in adjusted dose<br>* starting 7 days befoe coronary by-pass surgery<br>* Other names: zebeta;|
| Experimental: beta blocker and statin<br>The intervention will be that patients will receive beta blocker (Bisoprolol tab in adjusted dose)+ Rosuvastatin 20 mg. x 1 starting 7 days before coronary by-pass surgry untill discharge. | Drug: rosuvastatin 20 mg tab x1<br>* starting 7 days before coronary by-pass surgery<br>* Other names: crestor;Drug: beta blockers Bisoprolol in adjusted dose<br>* starting 7 days befoe coronary by-pass surgery<br>* Other names: zebeta;|
| Placebo Comparator: beta blocker<br>Patients will receive beta blocker (Bisoprolol tab in adjusted dose). | Drug: beta blockers Bisoprolol in adjusted dose<br>* starting 7 days befoe coronary by-pass surgery<br>* Other names: zebeta;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| atrial fibrillation | outcome will be number of patients free from atrial fibrillation. | 10 days on average during hospital stay after coronary by-pass surgery |
Somatostatin Receptor Imaging in Cardiac Sarcoidosis

Study Overview
=================
Brief Summary
-----------------
The purpose of the trial is to determine the accuracy of Cu-64 labelled DOTATATE for diagnosing cardiac sarcoidosis using PET/CT or PET/MRI.

Official Title
-----------------
Somatostatin Receptor Imaging in Cardiac Sarcoidosis

Conditions
-----------------
Cardiac Sarcoidosis

Intervention / Treatment
-----------------
* Drug: Cu-64 DOTATATE


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Group A: Suspected cardiac sarcoidosis Group B: Known cardiac sarcoidosis, clinical follow-up Group C: Myocarditis or dilated cardiomyopathy (Non-cardiac sarcoidosis) Exclusion Criteria: Infection Pregnancy Severe claustrophobia Weight >140 kg

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Suspected cardiac sarcoidosis<br>Cu-64 DOTATATE PET/CT or PET/MRI | Drug: Cu-64 DOTATATE<br> <br> |
| Known cardiac sarcoidosis<br>Cu-64 DOTATATE PET/CT or PET/MRI | Drug: Cu-64 DOTATATE<br> <br> |
| Other inflammatory cardiac disease<br>Cu-64 DOTATATE PET/CT or PET/MRI | Drug: Cu-64 DOTATATE<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sensitivity to detect cardiac sarcoidosis |  | 1 day at PET/CT examination | 
| Specificity to detect cardiac sarcoidosis |  | 1 day at PET/CT examination |
Standard Precautions Versus Contact Additional Precautions Against Multi-drug Resistant Bacteria in Intensive Care Unit (PSBMR)

Study Overview
=================
Brief Summary
-----------------
The national recommendations promote the applying of the Contact Additional Precautions (CAP) with the Standard Precautions (SP) to limit the transmission of multi-drug resistant (MDR) bacteria. However, that could entail more costs and a reduction of quality of the patient care.

Detailed Description
-----------------
The national recommendations promote the applying of the Contact Additional Precautions (CAP) with the Standard Precautions (SP) to limit the transmission of multi-drug resistant (MDR) bacteria. However, that could entail more costs and a reduction of quality of the patient care. This study seeks showing it in way of a non-interventional research in a resuscitation unit. Two periods are compared for noticing the rates of MDR bacteria contaminations.

Official Title
-----------------
Are Standard Precautions as Efficient as Contact Additional Precautions Against the Transmission of Multi-drug Resistant Bacteria in Intensive Care Unit ?

Conditions
-----------------
Multi-drug Resistant Bacteria

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: hospitalization in resuscitation unit Exclusion Criteria: opposition for gathering data
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of Meticillin Resistant Staphylococcus Aureus (MRSA) and Enterobacteriaceae producing Extended Spectrum Beta-Lactamase (EESBL) per 1000 hospitalization days |  | 1000 days |