The Effect of Mouthwash Containing Pomegranate Peel Extract and Chlorhexidine Mouthwash on Bleeding on Brushing

Study Overview
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Brief Summary
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To evaluate the clinical effectiveness of mouthwash containing pomegranate peel extract and chlorhexidine mouthwash on bleeding on brushing and counting of streptococcus mutans among a group of Egyptian children with permanent dentition.

Detailed Description
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To evaluate the clinical effectiveness of mouthwash containing pomegranate peel extract and chlorhexidine mouthwash on bleeding on brushing and counting of streptococcus mutans among a group of Egyptian children with permanent dentition. PICO: Population (P): Children with full permanent dentition. Intervention (I): Pomegranates peel extract. Comparator (C): Chlorhexidine. Outcome(O): Primary outcome: Bleeding on brushing, criteria:Asking patient, unit:Binary. Secondary outcome:Counting streptococcus mutans, criteria: Agar plate, unit: CFUs/mL

Official Title
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The Effect of Mouthwash Containing Pomegranate Peel Extract and Chlorhexidine Mouthwash on Bleeding on Brushing Among a Group of Egyptian Children With Full Permanent Dentition, Randomized Controlled Trial

Conditions
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Gingival Bleeding

Intervention / Treatment
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* Drug: Pomegranates peel extract
* Drug: Chlorhexidine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: children aged 12-15 years old. Cooperative children. Both genders. Medically free. Exclusion Criteria: Children undergoing orthodontic treatment. Children using any other oral hygiene aid other than routine teeth brushing. Children with known history of allergy to any mouth rinse or drug. Parents unable to give informed consent.

Ages Eligible for Study
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Minimum Age: 12 Years
Maximum Age: 15 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Pomegranate peel extract<br>Pomegranate is antimicrobial, anti inflammatory and antioxidant | Drug: Pomegranates peel extract<br>* Pomegranate is antimicrobial<br>|
| Active Comparator: Chlorhexidine<br>Chlorhexidine mouthwash is antiplaque treatment and effective against gingivitis | Drug: Chlorhexidine<br>* Chlorhexidine mouthwash is antiplaque agent<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bleeding on brushing, Measurement: asking patient , Unit: Binary |  | 2 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Counting streptococcus mutans, Measurement: Agar plate, Unit: CFUs/mL |  | 2 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Gingival Bleeding on probing