Low Resistance Venous Blood Flow Restriction Training (LR-VBFRT) on Biceps Brachii Muscle Performance

Study Overview
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Brief Summary
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Resistance training has been widely recognized as an effective stimulus for increasing skeletal muscle size and strength. This study intends to compare the effects of high resistance training without blood flow restriction and the low resistance training with blood flow restriction training on bicep muscle performance.

Detailed Description
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The study is Randomized Control Trail, which is being conducted in RIPHAH COLLEGE OF REHABILITATION SCIENCES. Sample size of 40 individual was calculated using Epitool with 95% confidence interval (CI) and power 80%. Individual will be screened out according to inclusion criteria. Individuals will be allocated randomly into two groups, 20 in high resistance training group and 20 in low resistance training with blood flow restriction group by sealed envelope method. High resistance training will be use in control group.Low resistance with blood flow restriction training will be used in experimental group. Assessment will be done on baseline 2-4 days prior to the intervention and after 8 weeks of training. Data will be analyzed on SPSS version 21.

Official Title
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Effects of Low Resistance Venous Blood Flow Restriction Training (LR-VBFRT) on Biceps Brachii Muscle Performance

Conditions
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Muscle Weakness Condition

Intervention / Treatment
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* Other: Low Resistance training with venous blood flow restriction
* Other: High Resistance training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Males Age: 20-28 year Body mass index: 18.5-24.9 Exclusion Criteria: Vascular Disease Upper Limb Pathology Requiring Surgical Intervention Upper Limb Musculoskeletal Issues Blood Pressure >140/90 Coronary Artery Disease Venous Thromboembolism Congenital Cardiac Diseases Syncope, Arrhythmias, Smokers Alcohol Use Supplements Intake whey Protein Intake

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 28 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Both experimental and control groups will be treated at the same time following their respective protocols
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Low Resistance Training Group<br>The experimental group will receive low resistance blood flow restriction training with 30% of 1 RM. | Other: Low Resistance training with venous blood flow restriction<br>* Total 20 males will participate in this group after warmup , Blood flow restriction will be provided through sphygmomanometer optimum pressure will be measured through following formula occlusion pressure (mmHg) = 0.514 (SBP) + 0.339 (DBP) + 1.461 (Arm circumference) + 17.236 then 30% of 1RM will be used for training . The standard protocol will be used which is four sets (1st set-30 repetitions, 2nd set-15 repetitions, 3rd set-15 repetitions, and 4th set-15 repetitions) with 30-60 s of interval between sets. ( the cuff must be deflated between sets of exercise) for 8 weeks (24) sessions on non-consecutive days. participants will be re-assessed for all baseline variables after 8 weeks of training biceps curls will be used for training. Heart Rate and oxygen saturation will be measured during the session through Pulse oximeter<br>|
| Active Comparator: High Resistance Training Group<br>Participants of this group will receive High resistance training (80% of 1 RM) without blood flow restriction. | Other: High Resistance training<br>* Total 20 males will participate in this group after warm up. 80% of 1RM will be used for training, 3 sets of 8 repetitions will be used with 30-60 s of interval between sets. for 8 weeks (24) sessions on non-consecutive days.No blood flow restriction will be applied to this group Participants will be re-assessed for all baseline variables after 8 weeks of training. Bicep curls will be used for training.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle strength | Handheld dynamometer will be used for measuring muscle strength of bicep muscle of all participants by single examiner | Baseline | 
| Muscle strength | Handheld dynamometer will be used for measuring muscle strength of bicep muscle of all participants by single examiner | Post 6 weeks | 
| 1 Repetition maximum | 1RM will be assess using Epley's formula of 1RM , RM= w(1+r/30) where w is the sub maximal weight and r is repetition then percentages of 1RM will be used for training purposes 80% of 1 RM for control group and 30% of 1RM for experimental group. | Baseline | 
| 1 Repetition maximum | 1RM will be assess using Epley's formula of 1RM , RM= w(1+r/30) where w is the sub maximal weight and r is repetition then percentages of 1RM will be used for training purposes 80% of 1 RM for control group and 30% of 1RM for experimental group. | Post 6 weeks | 
| Bicep Muscle power | Muscle power will be assesses of all the participants using power formula(Power= W/t= FS/t) for that force (F) will be assessed through dynamometer in newton covered distance (S) will be taken as covered range of motion and will be asses through goniometer (elbow flexion in supinated position). Time (t) will be calculated using stop watch | Baseline | 
| Bicep Muscle power | Muscle power will be assesses of all the participants using power formula(Power= W/t= FS/t) for that force (F) will be assessed through dynamometer in newton covered distance (S) will be taken as covered range of motion and will be asses through goniometer (elbow flexion in supinated position). Time (t) will be calculated using stop watch | Post 6 weeks | 
| Bicep muscle endurance testing | Bicep muscle endurance will be calculated prior to the intervention by asking participants to lift light -moderate weight and perform bicep curls in supinated position the total number of repetition they will perform doing complete eccentric and concentric movement of the muscle will be taken as the endurance of the bicep muscle | Baseline | 
| Bicep muscle endurance testing | Bicep muscle endurance will be calculated prior to the intervention by asking participants to lift light -moderate weight and perform bicep curls in supinated position the total number of repetition they will perform doing complete eccentric and concentric movement of the muscle will be taken as the endurance of the bicep muscle | Post 6 weeks | 
| Arm circumference | arm circumference will be measured in centimeters at the midpoint between the acromion process and the center of the elbow(by measuring tape) | Baseline | 
| Arm circumference | arm circumference will be measured in centimeters at the midpoint between the acromion process and the center of the elbow(by measuring tape) | Post 6 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Exercise Training