Internet-Based Clinical Information and Blood Sample Collection From Patients With Non-Small Cell Lung Cancer Who Never Smoked Cigarettes

Study Overview
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Brief Summary
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RATIONALE: Gathering health information about patients with non-small cell lung cancer who never smoked cigarettes may help doctors learn more about the disease. Collecting and storing samples of blood from patients with cancer to study in the laboratory may help doctors learn more about cancer and identify biomarkers related to cancer. PURPOSE: This research study is studying internet-based clinical information and blood sample collection from patients with non-small cell lung cancer who never smoked cigarettes.

Detailed Description
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OBJECTIVES: To assess the feasibility of an internet-based protocol to collect clinical information and biological specimens from 2,000 never smokers with non-small cell lung cancer. To perform genome-wide association studies to identify alleles that predispose to lung cancer in patients that never smoked cigarettes. OUTLINE: Patients complete an internet-based questionnaire using the REDCap (Research Electronic Data Capture) survey to determine eligibility. The survey consists of a detailed smoking questionnaire and questions to collect information regarding diagnosis, sex, age, ethnicity, treatment history, and any history of previous malignancies. Blood samples are then collected from eligible patients for DNA and other laboratory analyses. Patients' pathology reports are also reviewed.

Official Title
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Survey and Blood Sample Collection for Patients With Lung Cancer Who Never Smoked Cigarettes

Conditions
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Lung Cancer

Intervention / Treatment
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* Other: internet-based protocol and physician referral


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 years or older histologically and/or cytologically proven diagnosis of non-small cell lung cancer never smoker, defined as having smoked less than 100 cigarettes over one's life-time completed survey and inclusion form signed informed consent Exclusion Criteria: previous history of cancer (other than lung cancer, except for superficial skin cancers) living outside the United States patients who cannot read English (as materials will only be written in English) unable to understand the protocol or to give informed consent

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Never-smokers with lung cancer<br> | Other: internet-based protocol and physician referral<br>* collection and review, dna and lab biomarker analysis, gene mapping<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Feasibility of an internet-based protocol to collect clinical information and biological specimens |  | Six months following collection of final patient data and biospecimen | 
| Identification of alleles that predispose to lung cancer via genome-wide association studies |  | one year following collection of final patient data and biospecimen | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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non-small cell lung cancer