Apnoea-Hypopnoea-Indices Determined Via Continuous Positive Airway Pressure vs Those Determined by Polysomnography

Study Overview
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Brief Summary
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To date, no published systematic review and meta-analysis has compared AHI-CPAPflow and AHI-PSGgold. Therefore, the primary objective of this study is to compare published data for AHI-PSGgold and AHI-CPAPflow in patients treated by CPAP.

Detailed Description
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The secondary objectives are to evaluate, in a manner similar to the primary objective, data for apnoea indices (AI), hypopnoea indices (HI), respiratory disturbance indices (RDI) and respiratory effort related arousals (RERAs) and to perform subgroup analyses focusing on the inclusion/exclusion of central apnoea patients, BMI levels, CPAP device brands, pressure titration modes, use of a predetermined and fixed pressure level or not, and the impact of a 4%-PSG desaturation criteria versus 3%-PSG on index accuracy.

Official Title
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Apnoea-Hypopnoea-Indices Determined Via Continuous Posi-tive Airway Pressure (AHI-CPAPflow) Versus Those Determined by Polysomnography (AHI-PSGgold): a Protocol for a Systematic Review and Meta-analysis

Conditions
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Sleep Apnea Syndromes

Intervention / Treatment
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* Device: Continuous Positive Airway Pressure
* Device: Polysomnography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All (full scientific) study designs and publication types written in English and reporting Bland-Altman test results (or other tests suggesting the presence of the required data) between simultaneous, paired, polysomnography (PSG)-derived AND Continuous Positive Airway Pressure (CPAP)-derived data describing sleep disordered breathing. Exclusion Criteria: Duplicates Does not refer to a full scientific article (e.g. case reports are excluded). Meta-analysis Paediatric populations (populations <18 years are excluded). Absence of appropriate paired results: synchronized polysomnography (PSG)-derived AND Continuous Positive Airway Pressure (CPAP)-derived data must be reported for ≥1 of the following measures: Apnoea-Hypopnoea-Indices (AHI), Apnoea-Indices (AI), Hypopnoea-Indices(HI), respiratory disturbance index (RDI), respiratory effort related arousals (RERA). Absence of appropriate test comparing paired results: the study must use ≥1 of the fol-lowing tests to compare the previously mentioned PSG-vs-CPAP-derived data: a bland-altman or correlation test, other conformity tests, tests of differences in centrality. Inappropriate PSG scoring 1: PSG-derived variables must be coded following the American Academy of Sleep Medicine 2007 (or more recent) guidelines. Inappropriate PSG scoring 2: PSG-derived variables must be scored manually. Inappropriate PSG scoring 3: oxygen desaturation level used for scoring must be mentioned and at 3% or 4%. Inappropriate CPAP description: brand/device names must be mentioned.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| The study population<br>All (full scientific) study designs and publication types written in English and reporting Bland-Altman test results (or other tests suggesting the presence of the required data) between simultaneous, paired, polysomnography (PSG)-derived AND Continuous Positive Airway Pressure (CPAP)-derived data describing sleep disordered breathing. | Device: Continuous Positive Airway Pressure<br>* Continuous Positive Airway Pressure device deployed for at least one night synchronously with polysomnography.<br>Device: Polysomnography<br>* Polysomnography deployed for at least one night synchronously with Continuous Positive Airway Pressure.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The mean difference between AHI-CPAPflow and AHI-PSGgold | AHI-CPAPflow = Apnoea-Hypopnoea-Indices Determined Via Continuous Positive Airway Pressure AHI-PSGgold = Apnoea-Hypopnoea-Indices Determined by Polysomnography | Day 0 | 
| The standard deviation for the mean difference between AHI-CPAPflow and AHI-PSGgold |  | Day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The mean difference between AI-CPAPflow and AI-PSGgold | AI-CPAPflow = Apnoea--Indices Determined Via Continuous Positive Airway Pressure AI-PSGgold = Apnoea--Indices Determined by Polysomnography | Day 0 | 
| The standard deviation for the mean difference between AI-CPAPflow and AI-PSGgold |  | Day 0 | 
| The mean difference between HI-CPAPflow and HI-PSGgold | HI-CPAPflow = Hypopnoea--Indices Determined Via Continuous Positive Airway Pressure HI-PSGgold = Hypopnoea--Indices Determined by Polysomnography | Day 0 | 
| The standard deviation for the mean difference between HI-CPAPflow and HI-PSGgold |  | Day 0 | 
| The mean difference between RDI-CPAPflow and RDI-PSGgold | RDI-CPAPflow = Respiratory Disturbance Indices Determined Via Continuous Positive Airway Pressure RDI-PSGgold = Respiratory Disturbance Indices Determined by Polysomnography | Day 0 | 
| The standard deviation for the mean difference between RDI-CPAPflow and RDI-PSGgold |  | Day 0 | 
| The mean difference between RERA-CPAPflow and RERA-PSGgold | RERA-CPAPflow = Respiratory Effort Related Arousals Determined Via Continuous Positive Airway Pressure RERA-PSGgold = Respiratory Effort Related Arousals Determined by Polysomnography | Day 0 | 
| The standard deviation for the mean difference between RERA-CPAPflow and RERA-PSGgold |  | Day 0 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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CPAP, apnoea hypopnoea index