Long Term Health Cohort of Premature Infants

Study Overview
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Brief Summary
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Establish a clinical diagnosis and treatment and long-term follow-up database of preterm infants, and analyze the effects of prenatal factors (including genetic characteristics, maternal diseases, etc.), postnatal diagnosis and treatment measures and family maintenance environment after discharge on preterm infant mortality and major diseases in the near and long term.

Detailed Description
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As an increasing large group, the long-term quality of life and health status of preterm infants have become a very important public health problem in China. This cohort study is a single center clinical cohort study. By collecting the clinical diagnosis, treatment and follow-up data of preterm infants admitted to the neonatal department of our hospital for 3 consecutive years (about 1200 cases), and following them for 18 years, a relatively complete resource database for the long-term health and development of preterm infants is established. The effects of perinatal factors, diagnosis and treatment methods and family rearing environment on the survival rate, neurointelligence development, chronic metabolic diseases and respiratory diseases of preterm infants were analyzed. It provides a basis for further improving the diagnosis and treatment plan, exploring potential therapeutic targets and establishing prediction models.

Official Title
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A Cohort Study on the Long-term Health Outcomes of Premature Infants

Conditions
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Preterm

Intervention / Treatment
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* Diagnostic Test: Griffiths development scales


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Live born newborns with gestational age ≤ 36 + 6 weeks Transfer to the neonatal ward of Shanghai Children's medical center within 24 hours after birth Those who have lived in Shanghai for more than 1 year and plan to live in Shanghai for a long time. Parents voluntarily participated in the study and signed informed consent Exclusion Criteria: Premature infants: termination of treatment due to family factors (non-disease reasons) and hospitalization time ≤ 2 weeks Major congenital malformations Parents refuse to participate in the study

Ages Eligible for Study
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Minimum Age: 15 Days
Maximum Age: 4 Months

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Griffiths development scales|Griffiths development scales Chinese Edition (gds-c) was used to evaluate the development levels of children up to 6 years and WISC for children more than 6 years.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| neural development at 1 year old | Taking Griffiths development scales Chinese Edition test for all the participants. | 1 year | 
| neural development at 2 years old | Taking Griffiths development scales Chinese Edition test for partial participants. | 2 years | 
| neural development at 6 years old | Taking Wechsler Intelligence Scale for participants. | 6 years | 
| Growth and neural development at 12 years old | Taking Wechsler Intelligence Scale for participants. | 12 years | 
| Growth and neural development at 18 years old | Taking Wechsler Intelligence Scale for participants. | 18 years |