linjc16/ctgov huggingface dataset:
High-Resolution Optical Coherence Tomography for Detection of Retinal Nerve Fiber Layer Loss in Band Atrophy of the Optic Nerve

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to compare the abilities of high-speed,high-resolution (HR) optical coherence tomography (OCT) and Stratus OCT for detection of retinal nerve fiber layer (RNFL) loss in eyes with band atrophy (BA) of the optic nerve.

Official Title
-----------------
High-Resolution Optical Coherence Tomography for Detection of Retinal Nerve Fiber Layer Loss in Band Atrophy of the Optic Nerve

Conditions
-----------------
Band Atrophy, Chiasmal Compression, Neural Loss

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Visual acuity better than 20/30 Refractive error less 5 spherical diopter and 3 cylinder diopter Temporal field defect Exclusion Criteria: Presence of glaucoma and optic nerve anomalies A normal nasal field

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Patients with Band atrophy of the optic nerve | |
| 2<br>Normal Controls | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
High-Resolution Optical Coherence Tomography, Retinal Nerve Fiber Layer, Band Atrophy
Hypophosphatemia and Bronchiolitis

Study Overview
=================
Brief Summary
-----------------
Bronchiolitis is a major public health problem and the leading cause of paediatric intensive care unit admission in infants. Hypophosphatemia is common in adult intensive care units and was associated with an increase of the duration of mechanical ventilation and the length of stay. Our hypothesis is that hypophosphatemia is common in bronchiolitis and could be a marker of severity.

Official Title
-----------------
Hypophosphatemia In Infants With Severe Bronchiolitis: Prevalence And Risk Factors

Conditions
-----------------
Hypophosphatemia, Bronchiolitis

Intervention / Treatment
-----------------
* Biological: hypophosphatemia occurrence in infants with severe bronchiolitis admitted in a pediatric intensive care unit


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age > 7 days and < 3 months of life Admission to the pediatric intensive care unit from 01/11/2016 to 31/03/2020 With a diagnosis of moderate to severe bronchiolitis according to HAS 2019 criteria Exclusion Criteria: Renal Failure and tubulopathy Previous disorder of phospho-calcium balance Malignant pathology Lenght of stay less than 24 hours History of cardiac, aortic or hepatic surgery

Ages Eligible for Study
-----------------
Minimum Age: 7 Days
Maximum Age: 3 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Infants with hypophosphatemia<br>Infant less than 3 months with severe bronchiolitis admitted in a pediatric intensive care unit, with hypophosphatemia in the first 5th days | Biological: hypophosphatemia occurrence in infants with severe bronchiolitis admitted in a pediatric intensive care unit<br>* Serum phosphorus level < 1.55 mmol/L at any time between admission and the 5th day.<br>|
| Infants without hypophosphatemia<br>Infant less than 3 months with severe bronchiolitis admitted in a pediatric intensive care unit, without hypophosphatemia | Biological: hypophosphatemia occurrence in infants with severe bronchiolitis admitted in a pediatric intensive care unit<br>* Serum phosphorus level < 1.55 mmol/L at any time between admission and the 5th day.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hypophosphatemia occurrence in severe bronchiolitis in infants admitted in a pediatric intensive care unit | A serum phosphorus level< 1.55mmol/L defines the hypophosphatemia. | At any time in the first 5th days after Pediatric intensive care admission | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hypophosphatemia, Bronchiolitis, Paediatric Intensive Care Unit, Risk Factor
Comparison Between Low Pressure Versus High Pressure Laparoscopic Cholecystectomy

Study Overview
=================
Brief Summary
-----------------
The physiological changes and postoperative pain are directly related with the degree of intra-abdominal pressure kept during the laparoscopy. The present study aims to examine difference between low pressure pneumoperitoneum (8 mm Hg)and High pressure pneumoperitoneum (12 mm Hg)during laparoscopic cholecystectomy in terms of pain, cardio-pulmonary function, arterial blood gas changes etc.

Official Title
-----------------
A Prospective Randomized, Controlled Study Comparing Low Pressure Versus High Pressure Pneumoperitoneum During Laparoscopic Cholecystectomy.

Conditions
-----------------
Cholelithiasis

Intervention / Treatment
-----------------
* Procedure: Laparoscopic cholecystectomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: symptomatic gall stone disease Exclusion Criteria: pyocele gangrene of gall bladder history of cholangitis simultaneous CBD stones gall stone pancreatitis who does not give consent if they will be randomized to LPLC
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: LPLC, HPLC<br>LPLC: Low pressure pneumoperitoneum is defined as intraabdominal pressure kept at8 mm Hg after initial trocar insertion at 12 mm Hg HPLC: High pressure pneumoperitoneum is defined as intra abdominal pressure kept at 12 mm Hg throughout the procedure | Procedure: Laparoscopic cholecystectomy<br>* Laparoscopic cholecystectomy is performed at either 8 mm Hg or 12 mm Hg intra-abdominal pressure<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain |  | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pulmonary function |  | 24 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
laparoscopic cholecystectomy, low pressure pneumoperitoneum
Influence of Chronic Vascular Diseases on Transcranial Doppler Profiles in Critically Ill Patients

Study Overview
=================
Brief Summary
-----------------
The primary objective of this study is to show that cardiovascular risk factors associated with the chronic elevation of arterial resistance may be associated with false profiles of intracranial hypertension during transcranial doppler ultrasound of the middle cerebral arteries in intensive care unit patients. A false profile of intracranial hypertension is defined by a high pulsatility index without any intracranial pathology.

Official Title
-----------------
Influence of Chronic Vascular Diseases on Transcranial Doppler Profiles in Critically Ill Patients

Conditions
-----------------
Respiration, Artificial, Sedated

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria for entry in the study: Sedated patient under mechanical respiratory assistance Inclusion criteria for entry in group 1: the patient meets at least one of the following criteria: The patient is a man over the age of 50 or a woman over the age of 60 Hypercholesterolemia (LDL > 1.6 g/L, HDL < 0.4 g/L) Arterial hypertension for over 10 years (treated or systolic arterial pressure > 140 mmHG) Type 2 diabetes for over 10 years Active or former smoker in the past 3 years History of cardiovascular event (peripheral artery disease, heart attack, stroke/transient ischemic attack over 3 months ago) Chronic renal insufficiency with MDRD < 30 ml/min/1.73m^2 Inclusion criteria for entry in group 2: The included patient is not in group 1 Exclusion Criteria: acute neurological disorder (brain trauma, infectious or immune meningitis, meningoencephalitis, ischemic or hemorrhagic stroke <3 months) pregnant woman person under guardianship prisoners recent carotid surgery (<1 month)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1: With cardiovascular risk factors<br>Patients fall within this group when they have at least one of the cardiovascular risk factors listed in the eligibility criteria section. | |
| Group 1: Without cardiovascular risk factors<br>Patients fall into this group when they do not have any of the cardiovascular risk factors listed in the eligibility criteria section. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pulsatility index on the middle cerebral arteries |  | Day 0 | 
| Diastolic velocity at the middle cerebral arteries |  | Day 0 | 
| Mean velocity at the middle cerebral arteries |  | Day 0 |
Comparison of Amikacin Lung Delivery With Two Nebulizers

Study Overview
=================
Brief Summary
-----------------
Comparison between two modalities of nebulization.

Conditions
-----------------
Healthy, Cystic Fibrosis

Intervention / Treatment
-----------------
* Device: Nebulizer 1
* Device: Nebulizer 2


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male healthy subjects Cystic fibrosis Exclusion Criteria: Kidney failure No pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 16 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Nebulizer 1<br>Nebulization with akita nebulizer | Device: Nebulizer 1<br> <br> * Other names: Akita;|
| Active Comparator: Nebulizer 2<br>Nebulization with eFlow nebulizer | Device: Nebulizer 2<br> <br> * Other names: eFlow;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total urinary concentration of amikacin | Pharmacokinetic study of the urinary excretion of amikacin after nebulization | 24 hours after the nebulization | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Healthy Volunteers
Pelvic Floor Activity and Breathing in Women

Study Overview
=================
Brief Summary
-----------------
The pelvic floor and diaphragm work together in many different functions. Two important functions are breathing and continence. The pelvic floor muscles have to lift and squeeze to maintain continence. Breathing, specifically breathing out, makes the pelvic floor lift. The investigators don't know how much the pelvic floor lifts and squeezes during different types of breathing out. The purpose of this study is to measure pelvic floor lift and squeeze during different types of breathing out.

Detailed Description
-----------------
The pelvic floor (PF) activates automatically, both squeezing and lifting, during times of increased intra-abdominal pressure for postural stability and continence. Expiration additionally produces automatic activation of the PF. No study to date has investigated the effects of forced expiration on PF displacement and squeeze pressure. The purpose of this study was to investigate the effects of variations in forced expiration effort on PF muscles' automatic activation.

Official Title
-----------------
Effect Of Variations In Forced Expiration Effort On Pelvic Floor Activation In Asymptomatic Women

Conditions
-----------------
Pelvic Floor, Respiration

Intervention / Treatment
-----------------
* Other: Minimum expiration effort
* Other: Moderate expiration effort
* Other: Maximum expiration effort


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: women young (age 18-35) nulliparous pre-menopausal Exclusion Criteria: pregnancy history of lower back or pelvic pain history of lower back or pelvic surgeries incontinence history of pelvic floor dysfunction diabetes endometriosis neuromuscular disease connective tissue disease

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Single group: pelvic floor and breathing<br>This is a single group with repeated measures during variable breathing effort | Other: Minimum expiration effort<br>* Subjects perform a forced expiration at minimum effort<br>Other: Moderate expiration effort<br>* Subjects perform a forced expiration at moderate effort<br>Other: Maximum expiration effort<br>* Subjects perform a forced expiration at maximum effort<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pelvic floor, Rehabilitation, Respiration, Urinary incontinence
Relation Between Mean Pulmonary Artery Pressure and Pulmonary Acceleration Time and Comparison With Previous Formulae

Study Overview
=================
Brief Summary
-----------------
Since the pulmonary artery hypertension is defined based on MPAP and the two previous formulae relating MPAP and PAT were derived in western population, the investigator planned to conduct a prospective study to derive a new formula for measuring MPAP from PAT in Indian population and compare the accuracy of all the three formulae

Detailed Description
-----------------
After obtaining ethics committee approval and informed patient consent, minimum 25 patients > 18 years of age who are undergoing cardiac surgery with the invasive monitoring of pulmonary artery pressure will be enrolled in this study.The demographics and the preoperative echocardiographic measurement will be noted. In the operating room, once the intravenous access is obtained, central venous catheterisation and pulmonary artery catheterisation will be done as per the institutional protocol. Once the Transthoracic echocardiogram (TTE) is performed patient will be induced with opioids, intravenous or inhalational agents, and muscle relaxant according to the patient clinical and hemodynamic condition. Once the patient airway is secured with tracheal tube, transesophageal echocardiogram (TEE) will be performed before and after bypass, which is routine in all patients undergoing cardiac surgery in the institution. Echocardiographic images will be analysed by two separate echocardiographers to detect inter-individual variability. Patient blood pressure and heart rate will be maintained within 20% of their baseline value throughout surgery. Based on the patient condition at the end of surgery, extubation will be done in the operating room or in intensive care unit (ICU) after a period of elective ventilation.

Official Title
-----------------
Derivation of New Formula Relating Pulmonary Acceleration Time and Mean Pulmonary Artery Pressure in Indian Population and Comparison With Previous Formulas

Conditions
-----------------
Pulmonary Hypertension

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years of age who are undergoing cardiac surgery with the invasive monitoring of pulmonary artery pressure Exclusion Criteria: Patients with known right ventricular outflow tract obstruction, intra-cardiac shunt lesions will be excluded

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| WITH PULMONARY HYPERTENSION<br>It is defined as MPAP > 25 mm Hg at rest or >30 mm Hg during exercise with PVR > 3 wood units and PCWP < 15 mm Hg. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pulmonary acceleration time |  | Till post-extubation, an average of 2 days |
Somatropin (Norditropin) in Insulin-like Growth Factor (IGF) Deficient Children

Study Overview
=================
Brief Summary
-----------------
This trial is conducted in the United States of America (USA). This is a 12 month study to determine if Norditropin is safe and effective in children with IGF deficiency.

Official Title
-----------------
Somatropin (Norditropin) in Children With Growth Failure Associated With ICF Deficiency.

Conditions
-----------------
Growth Hormone Disorder, Pituitary Dwarfism

Intervention / Treatment
-----------------
* Drug: somatropin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Ages 3-15 Presence of growth failure indicated by height standard deviation score less than equal to -2 Body mass index greater than or equal to 25th percentile for height age IGF concentration less than or equal to 33rd percentile

Ages Eligible for Study
-----------------
Minimum Age: 3 Years
Maximum Age: 13 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: somatropin|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in height standard deviation score |  | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 12 months change in height standard deviation score adjusted for parent height z-score |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Growth Hormone Disorder
Use of Telemedicine in Collaboration Between a Psychogeriatric Unit and Nursing Homes

Study Overview
=================
Brief Summary
-----------------
The investigators want to evaluate the use of video-conference in the collaboration between the investigators psychogeriatric department and nursing homes. The study aim is to give supervision on a regular basis to the caregivers on a special care unit for patients with dementia with behavioural disturbances during a period of half a year. The investigators want to investigate the impact on caregivers and patients by applying certain tests at baseline, during the intervention and half a year after the intervention.

Official Title
-----------------
Use of Telemedicine in Collaboration Between a Psychogeriatric Unit and Nursing

Conditions
-----------------
Dementia, Behavioural Disorders

Intervention / Treatment
-----------------
* Behavioral: Training in person centered care by supervision using video-conference


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Being resident in a special care unit for persons with dementia Exclusion Criteria: Shorter stay than four weeks before inclusion terminally ill
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Training and supervision of staff<br>Staff members get training in person centered care by supervision using video-conference kit | Behavioral: Training in person centered care by supervision using video-conference<br>* The investigators will use video-conference for supervising and training of staff members in nursing homes<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neuropsychiatric inventory - nursing home version (NPI-NH) | The investigators want to find out if a supervision of staff members over a six months time, using video-conference technic, contributes to improvement in patients' behaviour registered by NPI-NH | week 48 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Person-centered Care Assessment Tool (P-CAT) Person centered care assessment tool (P-CAT) | Measures the effect of our intervention related to apply person centred dementia care | week 48 |