Circulatory Coherence in COVID-19 and Non-COVID-19 Patients With Sepsis

Study Overview
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Brief Summary
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This prospective observational pilot study investigates circulatory coherence in patients with COVID and non-COVID sepsis by comparison of microcirculation, endothelial glycocalyx, and clinical course

Detailed Description
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This prospective observational pilot study investigates circulatory coherence in patients with COVID and non-COVID sepsis by comparison of microcirculation (sublingual area video recordings and biochemical parameters of endothelial cells activation and damage) endothelial glycocalyx (sublingual area video recordings and biochemical parameter of glycocalyx degradation), and clinical course.

Official Title
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Circulatory and Endothelial Coherence in COVID-19 and Non-COVID-19 Patients With Sepsis - Prospective, Observational Pilot Study

Conditions
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Viral Pneumonia, Sepsis

Intervention / Treatment
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* Diagnostic Test: microcirculation recording


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adult ICU admission due to sepsis with organ failure need for organ support therapy (mechanical ventilation, CRRT, ECMO) clinical and/or laboratory signs of circulatory instability Exclusion Criteria: family withdrawal/disagreement death within three days from ICU admission

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| non-COVID sepsis<br>Patients admitted to ICU with sepsis of non-COVID origin | Diagnostic Test: microcirculation recording<br>* non-invasive recording of sublingual microcirculation and blood sampling together with regular withdraws<br>* Other names: biochemical markeres investigation;|
| COVID sepsis<br>Patients admitted to ICU with sepsis of COVID origin | Diagnostic Test: microcirculation recording<br>* non-invasive recording of sublingual microcirculation and blood sampling together with regular withdraws<br>* Other names: biochemical markeres investigation;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in Proportion of Perfused Vessels (PPV) parameter | PPV describes microcirculation dysfunction | 1st, 2nd and 3rd day | 
| change in Syndecan-1 serum concentration | Syndecan-1 is a marker of endothelial glycocalyx | 1st, 2nd and 3rd day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in albuminuria | albuminuria is a marker of glomerular endothelial cells dysfunction | 1st, 2nd and 3rd day | 
| mortality in 28 days | mortality in 28 days from ICU admission | 30 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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microcirculation, endothelial glycocalyx, COVID-19