Comparison of Cervical Ultrasound and Echoscintigraphy for Preoperative Localization Diagnosis in Primary Hyperparathyroidism

Study Overview
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Brief Summary
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The biological diagnosis of the primary hyperparathyroidism is now facilitated by the reliability of the balance of phosphate and calcium and the dosage of parathyroid hormone (PTH). This diagnosis of preoperative localization is important as surgery are now targeted to the responsible lesion. The gold standard for this localization is the cervical ultrasound exploring the usual sites of adenomas and a MIBI scintigraphy (the parathyroid adenoma significantly concentrating this cell marker). However, the diagnosis of preoperative localization remains a subject of discussion as to the most appropriate tests. Indeed, the morphological diagnosis is performed at the ultrasound stage in more than half the cases. It is the new performance of this morphological examination that makes it possible to obtain these results.

Official Title
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Comparison of Cervical Ultrasound and Echoscintigraphy for Preoperative Localization Diagnosis in Primary Hyperparathyroidism

Conditions
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Primary Hyperparathyroidism

Intervention / Treatment
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* Other: cervical ultrasound


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with primary hyperparathyroidism with surgery indication Age > 18yo Exclusion Criteria: surgical contraindication medical treatment by cinacalcet non sporadic hyperparathyroidism Age <18yo Protected by the law

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patients<br> | Other: cervical ultrasound<br>* cervical ultrasound will be realized by a endocinologist trained in the cervical ultrasound<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adenoma parathyroid diagnosed using cervical ultrasound | Adenoma parathyroid diagnosed using cervical ultrasound. Cervical ultrasound will be realized by a endocrinologist trained in the cervical ultrasound and not informed of the results of the echoscintigraphy | Day 0 | 
| Adenoma parathyroid diagnosed using echoscintigraphy | Adenoma parathyroid diagnosed using echoscintigraphy. Echoscintigraphy will be realized by a nuclear physician not informed of the results of the cervical ultrasound | Day 0 | 
| Adenoma parathyroid diagnosed using anatomopathology | Adenoma parathyroid diagnosed by anatomopathologist, after surgery. | Day 0 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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primary hyperparathyroidism, cervical ultrasound, echoscintigraphy