Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma

Study Overview
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Brief Summary
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The aim of this study is to investigate the change in iron metabolism in relation to malaria and helminth infections using a stable isotope technique.

Detailed Description
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The aim of the study is to determine how iron metabolism in subjects with infectious diseases (malaria, hookworm or S. haematobium) differs while infected and after treatment, i.e. the same individuals will be restudied while free of infection.

Official Title
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Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma.

Conditions
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Malaria, Falciparum, Hookworm Infections, Schistosoma Haematobium

Intervention / Treatment
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* Dietary Supplement: Fe-57 orally, Fe-58 intravenously


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Children aged 12 to 16 years Body weight > 30 kg no chronic medical illnesses no intake of vitamin/mineral supplements 2 weeks before the study and until the last blood drawing For each of the 4 arms the respective disease needs to be present (symptomatic malaria, asymptomatic malaria, hookworm infection, S. haematobium infection) without any other concurrent infection Exclusion Criteria: -

Ages Eligible for Study
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Minimum Age: 12 Years
Maximum Age: 16 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Symptomatic malaria infection<br> | Dietary Supplement: Fe-57 orally, Fe-58 intravenously<br>* Subjects will receive a test drink containing 3 mg Fe-57 in the form of labelled FeSO4 followed by 1 ml of an aqueous solution containing 50 μg Fe-58 as iron citrate.<br>|
| Other: Asymptomatic malaria infection<br> | Dietary Supplement: Fe-57 orally, Fe-58 intravenously<br>* Subjects will receive a test drink containing 3 mg Fe-57 in the form of labelled FeSO4 followed by 1 ml of an aqueous solution containing 50 μg Fe-58 as iron citrate.<br>|
| Other: Hookworm infection<br> | Dietary Supplement: Fe-57 orally, Fe-58 intravenously<br>* Subjects will receive a test drink containing 3 mg Fe-57 in the form of labelled FeSO4 followed by 1 ml of an aqueous solution containing 50 μg Fe-58 as iron citrate.<br>|
| Other: Schistosoma haematobium infection<br> | Dietary Supplement: Fe-57 orally, Fe-58 intravenously<br>* Subjects will receive a test drink containing 3 mg Fe-57 in the form of labelled FeSO4 followed by 1 ml of an aqueous solution containing 50 μg Fe-58 as iron citrate.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Isotope absorption into blood stream |  | Day 15 | 
| Isotope absorption into blood stream |  | Day 43 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Isotope incorporation into erythrocytes |  | Day 15 | 
| Biochemical parameters of iron status and infection |  | Day 1 | 
| Biochemical parameters of iron status and infection |  | Day 15 | 
| Biochemical parameters of iron status and infection |  | Day 29 | 
| Biochemical parameters of iron status and infection |  | Day 43 | 
| Isotope incorporation into erythrocytes |  | Day 43 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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iron absorption, iron utilization, malaria, helminth, Ivory Coast, Acute symptomatic uncomplicated falciparum malaria, Asymptomatic falciparum malaria, Moderate to heavy hookworm infection, Heavy Schistosoma haematobium infection