4-choice Reaction Time Test for the Measurement of Psychomotor Recovery After General Anaesthesia

Study Overview
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Brief Summary
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The recovery of patients after general anaesthesia is usually estimated by using clinical signs and scores. Since there is a lack of the agreed objective methods for assessing cognitive and psychomotor recovery after general anaesthesia in ambulatory settings, the aim of this study was to evaluate three psychological tests for this purpose. Patients, who were scheduled for ambulatory gynaecological surgery, underwent 3 standard psychological tests before (T1), 15 minutes after the surgery (T2) and on discharge from the recovery room (T3). The tests used were Wechsler memory scale (test 1, working memory capacity), d2 - test (test 2, concentration endurance) and computer-based 4-choice-reaction time (4CRT, test 3, reaction time) as well as Postanesthesia Discharge Scoring System (PADSS). The same test battery was used in healthy female volunteers, all test results were compared at the different time points.

Official Title
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Computerised 4-choice Reaction Time Test for the Measurement of Psychomotor Recovery After General Anaesthesia

Conditions
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Postoperative Complications

Intervention / Treatment
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* Procedure: General anaesthesia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: consecutive patients scheduled for ambulatory gynaecologic surgery age of 18 to 60 years a physical status I-II according to American Society of Anesthesiologists (ASA) classification fluency in German language and the ability to perform all tests Exclusion Criteria: chronic consume of analgesics, psychotropic drugs, sedatives or alcohol if the ambulatory surgery lasted more than 60 minutes if the schema of standardised general anaesthesia was changed if the ambulatory setting was changed and the patients unexpectedly remained over night in the hospital.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients<br>Patients scheduled for elective ambulatory gynaecological surgery, which was performed under standardised general anaesthesia | Procedure: General anaesthesia<br>* Standard general anaesthesia for gynecologic surgery in patient group<br>|
| healthy volunteers<br>Female healthy volunteers matched to the patient group regarding the age | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 4CRT_15_min | Change of four choice reaction time (4CRT) at 15 minutes after surgery from baseline | 15 minutes after the end of surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PADSS (Patient Discharge Scoring System) | Post Anaesthetic Discharge Scoring System (PADSS) is a clinically-based, objective scoring system used to measure the home readiness of patients following day surgery. PADSS consists of six criteria: ambulation, circulation (blood pressure monitoring), nausea/vomiting, pain and surgical bleeding bleeding. Each criterion is given a score ranging from 0 to 2, maximal score is 10. Only patients who achieve a score of 9 or more are considered ready for discharge. | Measured 60 minutes after the end of surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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postoperative recovery, psychomotor function, measurement