Esophageal Atresia: Metaplasia, Barrett

Study Overview
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Brief Summary
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The frequency of Barrett's esophagus (BE) has increased in adults in the last decades, but BE is rare in children. Esophageal atresia (EA), the most common congenital anomaly affecting the esophagus, predisposes the patient to severe and prolonged gastroesophageal reflux disease. Because gastroesophageal reflux disease plays a major role in the development of BE by causing repeated mucosal damage, development of BE is a concern even in children and young adults in this specific population. The aim of this study is to assess the prevalence of BE (gastric and/or intestinal metaplasia) in a population of adolescents/young adults who had been treated for EA in early infancy. All eligible patients received upper gastrointestinal endoscopy under general anesthesia with standardized esophageal staged biopsies. Histological suspicion of metaplasia was confirmed centrally.

Official Title
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Prevalence of Barrett's Esophagus in Adolescents and Young Adults With Esophageal Atresia

Conditions
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Gastroesophageal Reflux, Esophagus, Barrett

Intervention / Treatment
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* Procedure: esophageal biopsies


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Medical history of esophageal atresia (all types, Ladd's classification) Exclusion Criteria: No medical history of esophageal atresia Non acceptance to participate from the patient and/or his parents esophageal atresia treated with esophageal replacement (e.g., coloplasty, gastric transposition)

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| single group-study<br> | Procedure: esophageal biopsies<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| presence of gastric and / or intestinal metaplasia diagnosed at histology | Prevalence of Barrett's esophagus (gastric and/or intestinal metaplasia) in adolescents treated for esophageal atresia | during 2 hours of the endoscopy exam | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| presence of esophagitis or anomalies at the anastomotic stage diagnosed at histology |  | during 2 hours of the endoscopy exam | 
| evaluation of the nutritional status |  | during the single visit scheduled, the day of endoscopy. This periode is corresponding at a day hospitalization (less than 12 hours in the day) | 
| evaluation of actual symptoms and treatment of gastroesophageal reflux disease |  | during the single visit scheduled, the day of endoscopy. This periode is corresponding at a day hospitalization (less than 12 hours in the day) | 
| evaluation of actual other symptoms (respiratory, dysphagia) |  | during the single visit scheduled, the day of endoscopy. This periode is corresponding at a day hospitalization (less than 12 hours in the day) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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gastroesophageal reflux, barrett esophagus