linjc16/ctgov huggingface dataset:
Optimal Time for Follow up After Variceal Band Ligation

Study Overview
=================
Brief Summary
-----------------
Optimal time for follow up after variceal band ligation in cirrhotic patients remains to be determined

Detailed Description
-----------------
Optimal time for follow up after variceal band ligation in cirrhotic patients remains to be determined. So, we designed this trial to answer this question.

Official Title
-----------------
Optimal Time for Follow up After Variceal Band Ligation in Cirrhotic Patients: a Randomized Trial

Conditions
-----------------
Esophageal Varices

Intervention / Treatment
-----------------
* Device: Esophageal Variceal Band ligation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: cirrhotic portal hypertension with medium or large sized or risky varices or variceal bleeding Exclusion Criteria: non-cirrhotic portal hypertension
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: follow up every week<br>Variceal Band ligation every week. | Device: Esophageal Variceal Band ligation<br>* Band ligation of OV<br>* Other names: Band ligation;|
| Experimental: follow up every 2 weeks<br>Variceal Band ligation every 2 weeks | Device: Esophageal Variceal Band ligation<br>* Band ligation of OV<br>* Other names: Band ligation;|
| Experimental: follow up every 3 weeks<br>Variceal Band ligation every 3 weeks | Device: Esophageal Variceal Band ligation<br>* Band ligation of OV<br>* Other names: Band ligation;|
| Experimental: follow up every 4 weeks<br>Variceal Band ligation every 4 weeks | Device: Esophageal Variceal Band ligation<br>* Band ligation of OV<br>* Other names: Band ligation;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with eradicated varices | The total number of patients with eradicated varices | 1 year |
Improving Adherence to Prescribing Guidelines for Cholesterol Lowering in Hospitalized Diabetic Patients

Study Overview
=================
Brief Summary
-----------------
We hypothesize that when compared to usual care a greater proportion of hospitalized diabetic patients who are candidates for cholesterol lowering will be discharged with a prescription for a statin if their physicians are contacted by a pharmacist to discuss treatment guidelines.

Official Title
-----------------
Assisted Detailing to Improve Guideline Adherence

Conditions
-----------------
Diabetes, Dyslipidemia

Intervention / Treatment
-----------------
* Other: Academic detailing


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Hospitalized patients with diabetes LDL >= 100 Exclusion Criteria: Terminal illness Pregnancy Intolerance or contraindication to statin

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Academic detailing of physicians<br> | Other: Academic detailing<br>* Education of physicians by pharmacists regarding indications for statins in diabetic patients<br>|
| No Intervention: Usual care<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Statin prescription at hospital discharge |  | Hospital discharge (avg = 3 days) |
Can Blood Panels Provide Early Warning of Bleeding in Patients on ECMO?

Study Overview
=================
Brief Summary
-----------------
This is a prospective, observational study of 60 adult patients anticoagulated with bivalirudin for extracorporeal membrane oxygenation (ECMO). The study aims to identify the most precise early warning blood test or panel of blood tests to predict bleeding in patients on bivalirudin/ECMO. The project will involve comparing currently used blood tests with an extended panel of coagulation and metabolic blood tests with the aim of early warning of impending bleeding to allow intervention in the form of adjusted bivalirudin dose, modification of other risk factors, or transfusion with hemostatic products targeted to documented coagulation test abnormalities.

Official Title
-----------------
Can Blood Panels Provide Early Warning of Bleeding in Patients on ECMO?

Conditions
-----------------
ECMO, Bleeding

Intervention / Treatment
-----------------
* Diagnostic Test: Blood test of factor levels


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: adults 18 - 70 years who are anticoagulation (AC) with bivalirudin and placed on ECMO for cardiac and/or respiratory failure. Surgical and non-surgical patients will be included. Exclusion Criteria: known pre-existing bleeding disorder (due to a factor deficiency that requires factor replacement, or platelet disorder), or a creatinine > 2.0.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Major bleeders (MB)<br>Additional blood to be drawn from patients on ECMO who have a major bleeding event. | Diagnostic Test: Blood test of factor levels<br>* Blood draw from central line to check coagulation factors<br>|
| Non-major bleeders (NMB)<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of participants with changes in extended blood panel (EBP) for each of the bleeding and non-bleeding patient groups. | To determine if changes over time in an extended blood panel (EBP) and metabolic panel (MP) could provide early warning of impending bleeding in patients on ECMO. The extended blood panel includes: Dilute thrombin time (DTT), Factor XIII, Factor VIII, Factor IX, and Von Willebrand Disease (VWD) panel, and Factor XI, Factor X, Factor VII, Factor V, Factor II, protein C, protein S, thromboelastogram (TEG), and TEG-platelet mapping). | Up to 2 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of participants designated as major bleeders (MB) |  | Up to 2 weeks | 
| Number of participants designated as non-major bleeders (NMB) |  | Up to 2 weeks |
DNA Cytometry for Cervical Cancer Screening in China

Study Overview
=================
Brief Summary
-----------------
Very few screenings of any kind will be possible during a woman's lifetime in most low-resource regions, where 80% of the half-million global cases of cervical cancer occur every year. Although a single round of human papillomavirus (HPV) testing was associated with a significant decline in the rate of advanced cervical cancers and associated deaths, whether other methods like as DNA image cytometry can be used as an more accurate means than others in screening cervical cancer or not is yet to be verified. In addition, the accuracy of both DNA image cytometry and conventional cytology is not well known. The investigators hypothesized that DNA image cytometry was superior in screening cervical cancer than conventional cytology.

Official Title
-----------------
Comparison of DNA Image Cytometry and Conventional Cytology for Cervical Cancer Screening in China

Conditions
-----------------
Cervical Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Currently or had been married Not pregnant Had an intact uterus with no prolapse Had no history of cervical cancer Living in China Exclusion Criteria: Not willing to participate or finish the study at any time History of cervical surgeries

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Subjects underwent cervical sample DNA image cytometry | |
| 2<br>Subjects underwent cervical sample conventional cytology | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The incidence of cervical cancer. |  | From the testing performed by the investigator (0h) to one year follow-up period | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The rate of death. |  | One year follow-up period after screening. | 
| The incidence of cervical intraepithelial neoplasia. |  | From the screening (0h) to one year follow-up period | 
| Cervical inflammation |  | From the screening (0h) to one year follow-up period | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
DNA cytometry, Cytology, Diagnosis accuracy
Clinical Assessment of Indirect Restoration Fabricated From Nano Hybrid Composite Blocks Versus Ceramic Blocks in Badly Broken Teeth One Year Follow up

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to compare one-year clinical performance of indirect restoration fabricated from nano hybrid composite CAD CAM blocks and ceramic blocks

Detailed Description
-----------------
This research is conducted for comparing the clinical efficacy of nano hybrid composite blocks and ceramic blocks ., the choice of nano hybrid composite blocks based on the claim of the manufacturer, as it's considered to be promising , nano hybrid composite blocks has the highest fillers content (86% by weight), resembles natural teeth perfectly , Excellent physical values for flexural strength and abrasion, No firing required (a real one step ), can be processed using any conventional milling unit, can be finished and polished optimally, Ideal for grinding even in cases with thin edges.

Official Title
-----------------
Clinical Assessment Accourding to Modified Usphsof Indirect Restoration Fabricated From Nano Hybrid Composite Blocks Versus Ceramic Blocks in Badly Broken Teeth One Year Follow up Randomized Clinical Trial

Conditions
-----------------
Teeth Restoration

Intervention / Treatment
-----------------
* Drug: composite blocks
* Drug: ceramic cad cam blocks


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with badly broken vital teeth Young adult Males or female Good oral hygiene measures Cooperative patients approving to participate in the study Exclusion Criteria: Patients with a compromised medical history. Severe or active periodontal disease Severe medical complications Lack of compliance Endodontically treated teeth

Ages Eligible for Study
-----------------
Minimum Age: 16 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: ceramic cad cam blocks<br> | Drug: ceramic cad cam blocks<br>* ceramic cad cam blocks<br>|
| Active Comparator: composite cad cam blocks<br> | Drug: composite blocks<br>* cad cam composite blocks<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| marginal integrity | using usphs visual inspection | one year |
RWS of Inetetamab HER2 Positive Advanced Breast Cancer

Study Overview
=================
Brief Summary
-----------------
This non-Interventional study will describe and analyze the clinical use of Inetetamab in clinical practice in the treatment of HER2 positive advanced breast cancer in the real world.

Official Title
-----------------
Real World Study of Inetetamab HER2 Positive Advanced Breast Cancer

Conditions
-----------------
HER2-positive Advanced Breast Cancer

Intervention / Treatment
-----------------
* Drug: Inetetamab


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with stage IV breast cancer Patients with HER2 positive status Patients that received Inetetamab Patients that began Inetetamab therapy prior to June 30, 2021. Exclusion Criteria: Patients treated with an investigational anticancer agent Inetetamab

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| non-interventional study<br>Her2 positive ABC patients who have received Inetetamab in the metastatic setting. | Drug: Inetetamab<br>* 8mg/kg iv day 1 followed by 6mg/kg iv day 1, cycled every 21 days<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression Free Survival(PFS) |  | 12 months | 
| Incidences of adverse events and toxicities |  | 12 months |
Improving Vision and Quality of Life in the Nursing Home

Study Overview
=================
Brief Summary
-----------------
The primary purpose of this study is to evaluate whether interventions to improve vision in nursing home residents have an impact on residents' health-related quality of life. The interventions being evaluated are correction of refractive error (near-sightedness, far-sightedness, presbyopia) and cataract surgery.

Detailed Description
-----------------
The purpose of this project is two-fold: 1.) to establish the psychometric properties of the Nursing Home Vision-Specific Health-Related Quality of Life (HRQOL) instrument, and; 2.) to evaluate the responsiveness of this instrument. Responsiveness will be assessed in two independent preliminary prospective intervention evaluations. The first responsiveness evaluation will involve a new spectacle intervention and the second will involve first eye cataract surgery. In addition, we will examine the association between the responsiveness of this instrument, and changes in visual functioning measures and other demographic variables.

Official Title
-----------------
Improving Vision and Quality of Life in the Nursing Home

Conditions
-----------------
Refractive Error, Cataract

Intervention / Treatment
-----------------
* Device: spectacles
* Procedure: Cataract Surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: at least 60 years of age or older expected to stay in facility foe at least 8 months stable medical condition moderately cognitively impaired or better Exclusion Criteria: those not meeting inclusion criteria

Ages Eligible for Study
-----------------
Minimum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: spectacles|nan|
|Procedure: Cataract Surgery|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| vision-targeted health-related quality of life |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| depression |  |  | 
| generic health-related quality of life |  |  | 
| functional independence |  |  | 
| participation in group activities |  |  | 
| physical activities |  |  | 
| falls |  |  | 
| life space |  |  |
Breathing Pattern, WOB and Gas Exchange in Patients With Acute Respiratory Distress Syndrome During the Spontaneous Breathing Trial

Study Overview
=================
Brief Summary
-----------------
There is little evidence about the mechanical characteristics and muscular function in patients with Acute Respiratory Distress Syndrome (ARDS) at the time of weaning of the mechanical ventilation, as well as the behavior of the mechanical properties, breathing pattern, muscular effort, and gas exchange during a successful and failed spontaneous breathing trial.

Detailed Description
-----------------
The study of the respiratory system (RS) mechanics in patients with ARDS has been focused on the initial phase of ventilatory support, with few studies observing the weaning in mechanical ventilation.The RS in patients with ARDS is characterized by a greater or lesser degree of low functional residual capacity (FRC) in relation to normal. At the time of performing a spontaneous breathing trial, these mechanical characteristics determine the need to develop a high transpulmonary pressure during each breath, with high work of breathing (WOB) to achieve adequate alveolar ventilation. Inspiratory muscle weakness could alter the ability to generate the necessary transpulmonary pressure over time according to the loads imposed at the time of performing a spontaneous breathing trial, with the consequent development of fatigue and ventilatory failure. This is why the investigators propose to evaluate the association between elastic WOB and the failure of the spontaneous breathing trial.

Official Title
-----------------
Breathing Pattern, Work of Breathing and Gas Exchange in Patients With Acute Respiratory Distress Syndrome During the Spontaneous Breathing Trial

Conditions
-----------------
Work of Breathing, ARDS, Weaning Failure

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: over 18 years old requiring mechanical ventilation for more than 12 hours moderate/ severe ARDS according to Berlin Definition able to make a Spontaneous Breathing Trial according to the institution protocol Exclusion Criteria: pregnant patients history of neuromuscular disease patients in palliative care bronchopleural fistula contraindication of measurement of esophageal pressure

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Spontaneous breathing Trial | Period of time in which the patient breathes spontaneously | During 60 minutes after inclusion or until the patient fails to breathe spontaneously |
Indirect Laryngoscopy for Nasal Intubation

Study Overview
=================
Brief Summary
-----------------
Comparison of ease and convenience of nasotracheal intubation with the use of the two indirect laryngoscopes, Airtraq or Glidescope, versus the traditionally used Macintosh laryngoscope.

Official Title
-----------------
Indirect Versus Direct Laryngoscopy for Routine Nasotracheal Intubation: a Pilot Study

Conditions
-----------------
Intubation, Intratracheal

Intervention / Treatment
-----------------
* Device: Airtraq laryngoscope
* Device: Glidescope laryngoscope
* Device: Macintosh laryngoscope


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: nasotracheal intubation Exclusion Criteria: anticipated difficult airway risk factors for gastric aspiration history of bleeding relevant allergy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Airtraq<br> | Device: Airtraq laryngoscope<br>* Airtraq intubation<br>|
| Active Comparator: Glidescope<br> | Device: Glidescope laryngoscope<br>* glidescope intubation<br>|
| Active Comparator: Macintosh<br> | Device: Macintosh laryngoscope<br>* Macintosh intubation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intubation Difficulty Scale (IDS) |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Posture of the intubator |  |  |