linjc16/ctgov huggingface dataset:
Extracorporeal Therapy for the Removal of Myoglobin Using the CytoSorb in Patients With Rhabdomyolysis

Study Overview
=================
Brief Summary
-----------------
Prospective, randomized non-blinded, controlled study to assess the feasibility of the CytoSorb as an adjunct to the standard of care in patients with rhabdomyolysis requiring renal replacement therapy.

Conditions
-----------------
Rhabdomyolysis

Intervention / Treatment
-----------------
* Device: CytoSorb Device
* Procedure: CVVH


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subject is age 18-80 Subjects present with rhabdomyolysis Subject requires renal replacement therapy and has undergone adequate volume resuscitation Subject is willing to comply with specified follow up requirements Exclusion Criteria: Subject or their legal guardian either declines or cannot give informed consent Subject is pregnant Subject has been previously enrolled in this clinical study Comorbid condition that may limit survival to ≤14 days Comorbid condition that could confound study results Subjects who are receiving immunosuppressive therapy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: CVVH<br> | Procedure: CVVH<br> <br> |
| Experimental: CytoSorb Device<br> | Device: CytoSorb Device<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Efficacy of device as measured by change in myoglobin |  | 30 days | 
| Assessment of serious device or procedure-related adverse events |  | 30 days |
Follow-up of Endovascular Aneurysm Treatment - The FEAT Trial

Study Overview
=================
Brief Summary
-----------------
After endovascular abdominal aortic aneurysm repair, life-long follow-up is needed to monitor the effectiveness of exclusion of the aneurysm sac from blood flow. For this reason, aneurysm diameter and the presence of endoleaks is evaluated with CT angiography yearly after Endovascular Aneurysm Repair (EVAR). The aim of this study is to investigate the value of MRA examinations for the follow-up of these patients. The advantages of MRA with respect to CTA are no use of ionizing radiation, use of less nephrotoxic contrast agents.

Detailed Description
-----------------
The FEAT trial (Follow-up of Endovascular Aneurysm Treatment) is designed as a prospective, single-center, follow-up study. 100 Patients will be enrolled in this study. These patients will undergo additional MRA-examinations the day before EVAR, the day after EVAR, 6 months and 1 year after EVAR. These patients also participate in the conventional CTA follow-up scheme which comprises a pre- and post-operative CTA and a CTA yearly thereafter. Coagulation parameters in the blood will be measured before and 1 year after EVAR.

Official Title
-----------------
Follow-up Study of Endovascular Abdominal Aortic Aneurysm Treatment

Conditions
-----------------
Aortic Aneurysm, Abdominal

Intervention / Treatment
-----------------
* Procedure: Computed Tomography Angiography
* Procedure: Magnetic Resonance Angiography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient is planned for endovascular abdominal aortic aneurysm repair Exclusion Criteria: contraindication for MRI examination claustrophobia pacemaker other non-MRI compatible implants
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Computed Tomography Angiography|Computed Tomography Angiography|
|Procedure: Magnetic Resonance Angiography|Magnetic Resonance Angiography|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Blood Vessel Prosthesis Implantation, Endovascular aneurysm repair, Magnetic Resonance Angiography, Computed Tomography Angiography, Endoleak
Clinical Feature and Treatment of Microsporidial Keratoconjunctivitis

Study Overview
=================
Brief Summary
-----------------
The purpose of this project was to analysis the causes, pathogenesis, diagnostic modalities and treatment outcomes of microsporidial keratoconjunctivitis.

Detailed Description
-----------------
Microsporidia comprise a diverse group of obligate spore-forming intracellular eukaryotic pathogens first described in immunocompromised patients. Many species of microsporidia are found in aquatic environments, and they are considered as waterborne pathogens.Microsporidia are opportunistic pathogens that are reported to cause infections in various organs, including the eyes. The ocular appearance of this infection can manifest as corneal stromal keratitis or a superficial punctate keratoconjunctivitis. In particular, the characteristic feature of microsporidial keratoconjunctivitis is multiple whitish, slightly elevated epithelial lesions in conjunction with acute conjunctivitis. Awareness of microsporidial keratoconjunctivitis is increasing, and the number of cases reported is on the rise. This study was a retrospective case series of patients diagnosed as microsporidial keratoconjunctivitis. The purpose of this project was to analysis the causes, pathogenesis, diagnostic modalities and treatment outcomes of microsporidial keratoconjunctivitis

Official Title
-----------------
Clinical Feature and Treatment of Microsporidial Keratoconjunctivitis

Conditions
-----------------
Microsporidial Keratoconjunctivitis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients diagnosed as microsporidial keratoconjunctivitis Exclusion Criteria: Patients diagnosed as bacterial or viral keratoconjunctivitis

Ages Eligible for Study
-----------------
Minimum Age: 7 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Full chart records of the patients who diagnosed as microsporidial keratoconjunctivitis | Charts of all patients diagnosed as microsporidial keratoconjunctivitis between January, 2008 and April, 2018 at National Taiwan University Hospital were reviewed. | 2018/6/1-2019/5/31 |
Glycosylated Hemoglobin and Risk of Perioperative Major Cardiovascular Events in Diabetic Patients Undergoing Coronary Bypass Revascularization (HbA1c)

Study Overview
=================
Brief Summary
-----------------
Glycosylated Hemoglobin (HbA1c) is considered as one of the best markers to assess the glycaemia treatment over a period of 3 to 4 months, and is considered as predictive marker for perioperative mortality and morbidity. The impact of the elevated HbA1c on the risk of perioperative major cardiovascular events in patients undergoing coronary bypass revascularization (by retrospective analysis of perioperative cardiovascular events and preoperative HbA1c) is evaluated.

Official Title
-----------------
Glycosylated Hemoglobin and the Risk of Perioperative Major Cardiovascular Events in Diabetic Patients Undergoing Coronary Bypass Revascularization

Conditions
-----------------
Cardiovascular Event, Coronary Artery Bypass Graft, Diabetes Mellitus

Intervention / Treatment
-----------------
* Procedure: Coronary Bypass Revascularization


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with Diabetes mellitus undergoing coronary bypass revascularization since 2012 Exclusion Criteria: disapproval of use of data for research purposes
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Coronary Bypass Revascularization|analysis of perioperative major cardiovascular events in diabetic patients|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| occurence of Major adverse cardiac events | myocardial infarction, cardiac related death, stroke | perioperative = in hospital | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| occurence of severe renal insufficiency | application of renal replacement therapy (renal dialysis) | perioperative = in hospital | 
| occurence of sternal wound infection | sternal wound infection | perioperative = in hospital | 
| mortality | death rate perioperative | perioperative = in hospital |
Prevalence and Screening of Abdominal Aortic Aneurysms Among Men With Coronary Artery Disease

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to investigate the prevalence of abdominal aortic aneurysms (AAA) among male patients with coronary artery disease (CAD) verified in coronary angiography. Ethiology of AAA is known to be common with atherosclerotic arterial diseases (coronary artery disease, peripheral artery disease and carotid artery disease), so the hypothesis is that AAA should be more common among these CAD patients, thus making screening of these patients (for AAA) more cost-efficient. Study will be carried out as a multi-center prospective screening study. Data will be collected in North Karelia Central Hospital, Kuopio University Hospital and Tampere University Hospital. Data consists of 200 consecutive coronary angiography patients in each hospital, resulting in 600 patients in total. All male patients with diagnosed CAD will be recruited for the study and screened for AAA with ultrasound. Nevertheless, patients with previously known AAA will be excluded from the study.

Official Title
-----------------
Prevalence and Screening of Abdominal Aortic Aneurysms Among Men With Coronary Artery Disease

Conditions
-----------------
Abdominal Aortic Aneurysm

Intervention / Treatment
-----------------
* Other: ultrasound of aorta


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male patients with coronary artery disease Exclusion Criteria: Patient's denial to participate Female Gender Already diagnosed or treated abdominal aortic aneurysm
Sexes Eligible for Study
-----------------
Male

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: ultrasound of aorta<br> | Other: ultrasound of aorta<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximum diameter (mm) of abdominal aorta (outer-to-outer wall) in ultrasound |  | upon screening |
The Effect of Auricular Point Stimulation on Obese Women

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to examine whether the ear acupoint stimulation is effective on obese women.

Detailed Description
-----------------
% change body weight, BMI, lipid profile, glucose and obese hormone.

Official Title
-----------------
The Effect of Auricular Point Stimulation on Obese Women: a Randomized Controlled Trial

Conditions
-----------------
Obesity

Intervention / Treatment
-----------------
* Other: ear-acupuncture A
* Other: stimulation B
* Other: stimulation C


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 16-65 years women BMI>27 kg/mm Signed informed consent Exclusion Criteria: Endocrine disease, e.g. thyroid disorder, pituitary disorder, and sex gland disorder. Heart disease, e.g. arrhythmia, heart failure, myocardial infarction, and patient with pacemaker. Allergy and Immunology disease. High aminotransferases ( Alanine, Aspartate > 80 IU/L) or high serum creatinine (> 2.5 mg/dL) Pregnant or lactating women. Childbirth within 6 months. Stroke or otherwise unable to exercise Management for weight control within 3 months. Any other conditions deemed unsuitable for trial as evaluated by the physician-in-charge. Endocrine disease

Ages Eligible for Study
-----------------
Minimum Age: 16 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Stimulation A<br>with needle A stimulation | Other: ear-acupuncture A<br>* with needle stimulation<br>* Other names: ear acupuncture needle;|
| Active Comparator: Stimulation B<br>with stimulation | Other: stimulation B<br>* with bread stimulation on ear acupuncture point<br>* Other names: ear acupuncture bread;|
| Sham Comparator: Stimulation C<br>without needle | Other: stimulation C<br>* without needle stimulation<br>* Other names: placebo needle;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| % reducting of body mass index (BMI) |  | 4 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
ear acupuncture, obese, obese women, women
Oral Language in Children With Down Syndrome

Study Overview
=================
Brief Summary
-----------------
The objective of this research is to verify the language of children with Down syndrome concerning lexical, syntactic and semantic aspects using MLU. The hypothesis is that children with Down syndrome will present low performance, regarding not only the quantitative measures as MLU-m, MLU-w, GM-1 and GM-2, but also regarding the qualitative aspects of their production, when compared to children with typical development.

Detailed Description
-----------------
One of the alternatives to observe and assess language development and language disorders is to analyze spontaneous language samples, which allos the identification of qualitative and quantitative aspects. The analysis involves the MLU-morphemes, MLU-words and words classes. All words produced are analyzed, including interjections, adverbs and adjectives.Word classes with grammatical characteristics present lower averages, as prepositions and conjunctions. Reference parameters are the ones of the spoken language. The objective assessment with qualitative and quantitative data may help the speech and language pathologist/therapist to determine therapeutic guidelines to each patient.

Official Title
-----------------
Oral Language in Children With Down Syndrome: Lexical, Syntactic and Semantic Aspects

Conditions
-----------------
Down Syndrome

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: genetic diagnosis of Down syndrome good health conditions normal results on audiologic evaluation pediatric and ear, nose and throat periodic check ups. attend speech-language therapy at the Speech Language Pathology Laboratory in Syndromes and Sensorimotor Deficits (SLPL-SSD) of the School of Medicine of the University of São Paulo. Exclusion Criteria: submission to long term hospitalizations due to heart diseases and major respiratory airway infections, that may interfere in the child's global development presence of visual or auditory important deficits

Ages Eligible for Study
-----------------
Minimum Age: 3 Years
Maximum Age: 10 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| research group<br>60 children aged from 3 to 10 years, both genders, observed in a symbolic play situation with their language therapists | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Down syndrome, MLU, language development, language assessment
Periarticular Injection Versus Fascia Iliaca Block for Total Knee Arthroplasty

Study Overview
=================
Brief Summary
-----------------
In this study, the aim is to compare the efficacy of Periarticular multimodal drug injection(group PI) and Fascia Iliaca Compartment Block ( group FI)for total knee arthroplasty.

Detailed Description
-----------------
Total knee arthroplasty is very painful surgical intervention.Patients were assigned to 2 groups to receive either periarticular multimodal drug injection or fascia iliaca compartment block for postoperative pain.

Official Title
-----------------
Multimodal Periarticular Injection Versus Fascia Iliaca Compartment Block for Total Knee Arthroplasty

Conditions
-----------------
Total Knee Arthroplasty

Intervention / Treatment
-----------------
* Procedure: periarticular injection
* Procedure: fascia iliaca block


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients undergoing knee arthroplasty > 18 years of age Exclusion Criteria: obesity heart failure kidney failure liver failure

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: group PI<br>group PI were performed periarticular drug injection during surgery. | Procedure: periarticular injection<br>* patients were performed bupivacaine solution to the periarticular soft tissues during surgery by the surgeon.<br>|
| Active Comparator: group FI<br>group FI were performed fascia iliaca block before surgery | Procedure: fascia iliaca block<br>* patients were performed fascia iliaca block with bupivacaine solution before surgery.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative pain scores of periarticular injection and fascia block for total knee arthroplasty | Patients were assigned in two groups to perform either periarticular injection (group PI) and fascia block ( group FB). They were accessed by visual analog scale. The aim was to compare the efficacy and side effects of periarticular injection and fascia block. | postoperative 24 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
periarticular drug injection, fascia iliaca block, knee arthroplasty
Navigation System for in Vivo Measurement of the Kinematics of the Knee

Study Overview
=================
Brief Summary
-----------------
The knee prosthesis is a validated treatment for end-stage osteoarthritis, and this intervention usually provides a significant improvement in the quality of life of patients. However, a significant percentage of patients (up 30%) say disappointed with the outcome of the intervention. One hypothesis that could explain these poor results might be poor adaptation of the implants to the patient's anatomy, resulting in a non-physiological kinematics for the patient. Multiple studies try to obtain an individual adaptation of the intervention according to multiple criteria. The measurement of the kinematics of the knee before surgery could participate in this process.

Official Title
-----------------
Validation of a Noninvasive Navigation System for in Vivo Measurement of the Kinematics of the Knee

Conditions
-----------------
Knee Osteoarthritis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients over 18 years Patients operated in the service in 2014 to care for end-stage knee osteoarthritis by implantation of a total hip knee prosthesis. Exclusion Criteria: Patients under 18 years

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| in vivo measurement of the kinematics of the knee |  | patient's medical data will be collected by health professional for the duration hospital stay, up to 1 year] | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Knee, Knee osteoarthritis, Knee replacement