Wine Consumption and Glycemic Control

Study Overview
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Brief Summary
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Many studies have reported that alcoholic beverage consumption, especially in the form of wine, reduces the risk of developing type 2 diabetes by as much as 40%. This association suggests that wine consumption may somehow improve the body's ability to control its blood glucose concentration. Indeed, it has been reported that when wine is consumed immediately prior to ingestion of glucose, the release of insulin is enhanced and blood glucose concentration is lowered. The mechanism of wine's effects on blood glucose concentration is unknown, but is likely related to its ethanol or antioxidant content. In this study, the investigators plan to test whether wine or plain ethanol (vodka) ingestion alters the control of blood glucose in subjects who have diabetes or pre-diabetes.

Detailed Description
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Our central hypothesis is that improvement in glycemic control by acute consumption of wine is mediated by ethanol. Subjects will have type 2 diabetes, pre-diabetes, and be sedentary and obese (BMI >30). Subjects' glycemic control will be assessed by an oral glucose tolerance test (OGTT) at three different time points. One OGTT will occur shortly after consumption of red wine, the second after consumption of vodka containing the identical amount of ethanol as the wine treatment, and the third OGTT will occur shortly after consumption of an equal volume of water. The three OGTTs will be administered in random order.

Official Title
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Wine Consumption and Glycemic Control

Conditions
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Diabetes Mellitus, Type 2

Intervention / Treatment
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* Other: Alcohol consumption


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: insulin resistant: diagnosed with pre-diabetes or fasting blood glucose >/= 97 mg/dL T2D: diagnosed by primary care physician at risk of type 2 diabetes (obesity and physically inactive) age: 21-65 Exclusion Criteria: smoking insulin use (other than once daily) physically active (>30 mins aerobic exercise two days/week) recent (>3 mo) changes in medication use or dose uncontrolled type two diabetes (HbA1C >10%) advanced retinopathy or neuropathy pregnancy

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Alcohol consumption<br>Alcohol consumption and wine consumption | Other: Alcohol consumption<br>* 28 grams (2 drinks) of ethanol will be consumed either in the form of wine or vodka.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Oral glucose tolerance test | Measurement of blood glucose taken every 15 minutes over a course of three hours. | 3 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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type two diabetes, glycemic control