Body Composition and White Adipose Tissue Inflammation

Study Overview
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Brief Summary
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The investigators want to find a better way to predict the risk of having fatty tissue inflammation by using a different approach to finding out body fat composition. In this study, the investigators want to estimate the body fat composition using a DEXA scan. DEXA stands for dual energy X-ray absorptiometry. It is the standard and established test to determine bone mineral density (how strong the bones are) to diagnose osteoporosis. This test can also be used to determine the body composition including percent body fat and lean mass. The investigators will compare the participants DEXA scan results for body fat composition to the inflammation found in the breast tissue from the mastectomy to see if there is a relationship. If successful, this may help us predict which patients may be at risk for breast cancer in the future. In addition, the investigators will compare the participants DEXA scan results for body fat composition and inflammation found in the fat tissue from the mastectomy or prostatectomy to the level of exercise activity as measured by a short questionnaire to see if there is a relationship. The investigators will also measure the participants waist to hip ratio. Finally, at the time the participant has blood drawn for their standard presurgical testing, the investigators will also test the blood for prediabetes using a blood test called hemoglocin A1c. The investigators will also measure for the participants waist to hip ratio, and a Hgb A1c blood drawn will be take at the time of presurgical testing. If not feasible, Hgb A1c can be drawn at a separate visit prior to the DEXA scan. If successful, this may help us predict which patients may be at risk for breast cancer in the future.

Official Title
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Body Composition and White Adipose Tissue Inflammation

Conditions
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Breast Cancer, Prostate Cancer, Body Composition, White Adipose Tissue Inflammation

Intervention / Treatment
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* Device: DEXA Scan
* Behavioral: Godin Leisure Time Exercise Questionnaire (GLTEQ)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥ 18 Female All BMIs Patients undergoing mastectomy at MSKCC (i.e. Nipple-sparing mastectomy, skin-sparing mastectomy, simple mastectomy, modified radical mastectomy, radical mastectomy); mastectomy may be either prophylactic or therapeutic. OR Patients undergoing hysterectomy at MSKCC History of prior breast surgeries/procedures is acceptable Exclusion Criteria: Pregnancy (confirmed or suspected); Inability to lay supine on equipment table and maintain the position for the necessary time; Weight superior to the maximum allowed by the DEXA machine (over 350 lbs or 158 kg); Greater than 10% baseline weight loss in the past year; Planned surgical procedure is not a Mastectomy (i.e. breast conservation surgery or other non-mastectomy procedure; such as lumpectomy) or hysterectomy Metastatic cancer History of Wasting Syndromes or Cachexia Use of daily NSAIDs, aspirin, or steroids (other than inhaled or topical) within 30 days of surgery Use of neoadjuvant systemic or radiation therapy.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Breast Cancer<br>DEXA scan will be carried out 1 to 30 days prior to mastectomy. Patients will also complete the Godin Leisure Time Exercise Questionnaire (GLTEQ) and their waist to hip ratio will be measured. | Device: DEXA Scan<br> <br> Behavioral: Godin Leisure Time Exercise Questionnaire (GLTEQ)<br> <br> |
| Prostate Cancer<br>DEXA scan will be carried out 1 to 30 days prior to radical prostatectomy. Patients will also complete the Godin Leisure Time Exercise Questionnaire (GLTEQ) and their waist to hip ratio will be measured. | Device: DEXA Scan<br> <br> Behavioral: Godin Leisure Time Exercise Questionnaire (GLTEQ)<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| fat percentage | as measured by DEXA | 1 year | 
| presence of White Adipose Tissue Inflammation (WATi ) | as measured by DEXA | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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DEXA Scan, 15-235