Effect of Honey and Dexamethason on Extraction Healing

Study Overview
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Brief Summary
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Natural honey and dexamethason will be given before impaction removal then postoperative complications will be evaluated

Detailed Description
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Patient with impacted lower third molar will be selected to this study agording to agent applied preoperative. Group 1 will receive topical honey and Group 2 will receive IV dexamethason. After surgical removal of impacted tooth under local anesthesia postoperative pain mouth opening, and swelling will be evaluated

Official Title
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A Novel Therapeutic Approach for Controlling Complications Associated With Impacted Mandibular Third Molar Removal

Conditions
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Impacted Third Molar Tooth

Intervention / Treatment
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* Drug: Normal saline
* Drug: Dexamethasone
* Drug: Honey
* Drug: Dexamethasone and honey


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: impacted 3rd molar healthy patient No smoking Exclusion Criteria: history of smoking Medical disease

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Control<br>No drug given before surgery | Drug: Normal saline<br>* Saline will be applied after surgery<br>|
| Active Comparator: Dexamethason<br>Dexamethason will be given IV before surgery | Drug: Dexamethasone<br>* Dexamethason will be given IV before surgery<br>|
| Active Comparator: Natural honey<br>Honey will be placed locally after impaction removal | Drug: Honey<br>* Honey will be applied locally after surgery<br>|
| Active Comparator: Dexamethason and natural honey<br>Dexamethason will be given IV before surgery and Honey will be placed locally after impaction removal | Drug: Dexamethasone and honey<br>* Dexamethason will be given IV before surgery and then Honey will be applied locally after surgery<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Interincisal distance | Distance between upper and lower teeth will be measured in mm by ruler | Preoperative | 
| Interincisal distance | Distance between upper and lower teeth will be measured in mm by ruler | I day postoperative | 
| Interincisal distance | Distance between upper and lower teeth will be measured in mm by ruler | 3rd day postoperative | 
| Interincisal distance | Distance between upper and lower teeth will be measured in mm by ruler | 7th day postoperative | 
| Edema | Measured from angle of mandible to angle of mouth | Preoperative | 
| Edema | Measured from angle of mandible to angle of mouth | 1day postoperative | 
| Edema | Measured from angle of mandible to angle of mouth in mm by ruler | 2nd day postoperative | 
| Edema | Measured from angle of mandible to angle hof mouth in mm by ruler | 3rd day postoperative | 
| Edema | Measured from angle of mandible to angle of mouth in mm by ruler | 7th day postoperative |