Improvement of Sarcopenia in Patients Following Two Different Diets

Study Overview
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Brief Summary
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Sarcopenia is defined as a decrease in muscular strength and muscle mass, accompanied by a decrease in physical performance. Seniors might develop sarcopenia because of a decreased physical activity and a decreased protein intake. Many patients also develop sarcopenia after a long stay in an intensive care unit. Protein intake is very important when treating sarcopenia. However, meeting the protein requirements at home proves difficult. Oral dietary supplements, given in addition to the other known recommendations, might provide a solution. This study will assess the efficacy of the oral dietary supplements for the treatment of sarcopenia.

Official Title
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Improvement of Sarcopenia in Sarcopenia Patients Following Two Different Diets

Conditions
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Sarcopenia

Intervention / Treatment
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* Dietary Supplement: Oral dietary supplements


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients hospitalized within the CHU Brugmann, Brussels Patients diagnosed with sarcopenia (by means of a dynamometer) Patients having stayed in an intensive care unit for longer than 5 weeks Exclusion Criteria: Oncology patients Anorexic patients Patients having a life expectancy of less than 6 months Demented patients BPCO patients Patients with neuropathies

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Standard treatment<br> | |
| Experimental: Oral dietary supplements<br> | Dietary Supplement: Oral dietary supplements<br>* Protein enriched diet<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prehension force | Prehension force, as measured by a dynamometer on the dominant hand | 3 months after first consultation | 
| Prehension force | Prehension force, as measured by a dynamometer on the dominant hand | 6 months after first consultation | 
| Fat mass evaluation | Measured by a Harpaden compass on the tricipital skin fold | 3 months after first consultation | 
| Fat mass evaluation | Measured by a Harpaden compass on the tricipital skin fold | 6 months after first consultation | 
| Muscle mass evaluation | Brachial muscular circumference (measured by tape) | 3 months after first consultation | 
| Muscle mass evaluation | Brachial muscular circumference (measured by tape) | 6 months after first consultation | 
| Walking speed | Walking speed on a 4 meters distance | 3 months after first consultation | 
| Walking speed | Walking speed on a 4 meters distance | 6 months after first consultation | 
| Time Up and Go test | Mobility assessment of the patient | 3 months after first consultation | 
| Time Up and Go test | Mobility assessment of the patient | 6 months after first consultation | 
| Sedentary lifestyle questionnaire | Evaluation of the physical activity by means of a questionnaire | 3 months after first consultation | 
| Sedentary lifestyle questionnaire | Evaluation of the physical activity by means of a questionnaire | 6 months after first consultation |