Social Cognition in Ageing and in Frontotemporal Lobar Degeneration

Study Overview
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Brief Summary
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The purpose of this study is to examine the age and the neurodegenerative disease effects on social cognition. Secondary goals are to better understand the relationships between different component of social cognition, executive functioning, and behavior and describing the neuronal substrates associated to the alteration of the social cognition in ageing and dementia.

Official Title
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Social Cognition in Ageing and in Frontotemporal Lobar Degeneration (Frontotemporal Dementia and Semantic Dementia): a Cognitive and Neuroimaging Study

Conditions
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Frontotemporal Lobar Degeneration, Aging

Intervention / Treatment
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* Behavioral: Cognitive assessment
* Other: Brain imaging examination MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All the participants Age between 40 and 80 years Minimum of 7 years of education French native speaker Healthy subjects Non pathological Dementia rating scale score Patients Clinical diagnosis of frontotemporal lobar degeneration Exclusion Criteria: Chronic neurological disease Encephalitis Endocrinal disease Hepatic disease Case history of head injury with loss of consciousness of more than one hour Case history of stroke Case history of cancer during the five last years except squamous cell carcinomas Alcoholism or drug addiction Major psychiatric disorders according the Diagnostic and Statistical Manual of Mental Disorders

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Non-Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Semantic demantia<br>cognitive assessment and Brain imaging examination MRI of patient with the semantic variant of primary progressive aphasia | Behavioral: Cognitive assessment<br> <br> Other: Brain imaging examination MRI<br> <br> |
| Experimental: Frontotemporal dementia<br>cognitive assessment and Brain imaging examination MRI of patients with the behavioral variant of frontotemporal lobar degeneration | Behavioral: Cognitive assessment<br> <br> Other: Brain imaging examination MRI<br> <br> |
| Experimental: Elderly<br>cognitive assessment and Brain imaging examination MRI of healthy elderly subjects | Behavioral: Cognitive assessment<br> <br> Other: Brain imaging examination MRI<br> <br> |
| Experimental: Young<br>cognitive assessment and Brain imaging examination MRI of young subjects | Behavioral: Cognitive assessment<br> <br> Other: Brain imaging examination MRI<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Social cognition scores | number of correct responses in a social cognition test | 2 years |