Clinic Features and Outcome of BPD (SGBPD)

Study Overview
=================
Brief Summary
-----------------
This study described the perinatal high-risk factors and clinical manifestations of the children, and compared the high-risk factors, clinical manifestations and prognosis of BPD among different clinical subtypes by comparison between groups. BPD grading was performed using the 2018 grading standard to compare the distribution of I/II/III BPD among different groups.

Official Title
-----------------
Clinic Features and Long-term Outcome of Different Subgroups of Brochopulmonary Dysplasia in Preterm Infants

Conditions
-----------------
Bronchopulmonary Dysplasia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Premature infants born at <32 weeks of gestational age; hospitalization time ≥ 14 days; The clinical medical records are complete Exclusion Criteria: • 1) Children with congenital heart, lung malformation and definite chromosomal diseases; 2) children gave up treatment halfway; 3) corrected gestational age 36 weeks before death, the cause of death was confirmed as factors other than respiratory system.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| no BPD<br>In preterm infants(GA<32 weeks and hospital day>14 days )，infants without BPD | |
| classic BPD<br>In preterm infants(GA<32 weeks and hospital day>14 days )，There are clinical manifestations and imaging evidence of RDS after birth, the condition is not relieved, FiO2 lasts >25% | |
| BPD after RDS<br>In preterm infants(GA<32 weeks and hospital day>14 days )，There are clinical manifestations and imaging evidence of RDS after birth. FiO2<23% within 7 days, and the condition is aggravated to FiO2>25%. | |
| Delayed BPD<br>In preterm infants(GA<32 weeks and hospital day>14 days )，There is no RDS performance after birth, FiO2 lasts <25% | |
| Early, lethal BPD<br>In preterm infants(GA<32 weeks and hospital day>14 days )，Some infants who die before 36 weeks PMA (between 14 days of postnatal age and 36 weeks) due to persistent parenchymal lung disease and respiratory failure that can not be attributable to other neonatalmorbidities | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | Different subtype of BPD infants against the total BPD infants in corresponding group | up to 12 months after birth | 
| Serious respiratory mobidities | occurence of at least one of the following: tracheostomy, continued hospitalization for respiratory reasons at or beyond 50weeks PMA; continued oxygen supplement or respiratory support beyond 12months after birth; readmission for respiratory reasons. | up to 18 months after birth | 
| Duration of first hospital stay | days between admission and first discharge | up to 12 months after birth | 
| Days with oxygen supplement | days during which the infants were given oxygen | up to 12 months after birth | 
| Days of Mechanical Ventilation | days during which the infants were given mechanical ventilation | up to 12 months after birth | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| weight | the measure of infant's length | up to 18months after birth | 
| length | the measure of infant's weight | up to 18months after birth | 
| head circumference | the measure of infant's head circumference, which is the occipital-frontal circumference | up to 18months after birth |