Synergy Between PCI With TAXUS and Cardiac Surgery: SYNTAX Extended Survival

Study Overview
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Brief Summary
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An investigator-driven, retrospective study to compare long-term survival-data (10-year follow-up) of patients with coronary artery disease (CAD), previously enrolled in the SYNTAX trial, who were randomized to percutaneous coronary intervention (PCI) using a paclitaxel (TAXUS) drug-eluting-stent (DES) or coronary artery bypass grafting (CABG).

Official Title
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Synergy Between PCI With TAXUS and Cardiac Surgery: SYNTAX Extended Survival

Conditions
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Coronary Artery Disease

Intervention / Treatment
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* Other: No intervention will take place for this retrospective and observational study.


Participation Criteria
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Eligibility Criteria
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Patients which have previously been enrolled in the SYNTAX trial (randomized and registry patients)

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Randomized CABG patients<br>Patients which were randomized to undergo CABG. | Other: No intervention will take place for this retrospective and observational study.<br>* No intervention will take place for this retrospective and observational study.<br>|
| Randomized PCI patients<br>Patients which were randomized to undergo PCI. | Other: No intervention will take place for this retrospective and observational study.<br>* No intervention will take place for this retrospective and observational study.<br>|
| Registry CABG<br>Patients for whom only one treatment option was suitable were included into a parallel, nested registry: the CABG registry for PCI-ineligible patients. | Other: No intervention will take place for this retrospective and observational study.<br>* No intervention will take place for this retrospective and observational study.<br>|
| Registry PCI<br>Patients for whom only one treatment option was suitable were included into a parallel, nested registry: the PCI registry for CABG-ineligible patients. | Other: No intervention will take place for this retrospective and observational study.<br>* No intervention will take place for this retrospective and observational study.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Long-term survival status | All-cause death | 10-year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cause of death | Cause-specific death, separated in cardiovascular and non-cardiovascular death with specific causes for cardiovascular deaths. | 10-year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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coronary artery bypass grafting, percutaneous coronary intervention, drug eluting stent, survival status, long-term follow-up, complex coronary artery disease