Energy Metabolism in Patients With Short Bowel Syndrome

Study Overview
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Brief Summary
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This study proposes to verify the total energy expenditure in patients with short bowel syndrome using the doubly labeled water method, as well as determining the rate of oxidation of nutrients, aiming to assist the management of nutritional therapy for these patients.

Official Title
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Assessment of Energy Metabolism in Patients With Short Bowel Syndrome Using the Doubly Labeled Water Method

Conditions
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Short Bowel Syndrome

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Short bowel syndrome: short bowel syndrome patients with gastrointestinal transit time less or equal 30 minutes. Control group: patients with the same gender, presenting age and chronic diseases similar with volunteers from the group with short bowel syndrome. Exclusion Criteria: - Short bowel syndrome: time of bowel resection surgery less than 1 year.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Short Bowel Syndrome<br>Verify the total energy expenditure in patients with short bowel syndrome using the doubly labeled water method. | |
| Control Group<br>Verify the total energy expenditure in patients without short bowel syndrome using the doubly labeled water method. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assessment of total energy expenditure using the doubly labeled water method | After the determination of resting energy expenditure (REE), each volunteer will receive a dose of doubly labeled water (2H2 18O). A basal urine sample is collected before the intake dose and samples taken on days 1, 2, 3, 7, 12, 13, 14, thereafter. Urine samples will be analyzed by mass spectrometry (Hydra System, HIP 20-20, Europa Scientific, Cheshire, UK) in the Mass Spectrometry Laboratory of the Faculty of Medicine of Ribeirão Preto. | 14 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Resting energy expenditure (REE) and body composition measurements by indirect calorimetry and electrical bioimpedance, respectively. | This study also aims to measure the REE by indirect calorimetry with a Quark (Cosmed, Italy) calorimeter and the body composition by Byodinamics 450 (Biodynamics Corp., United States). | After 12 hours of overnight fasting | 
| Physical activity assessment | An activity monitor (activPAL ®, Glasgow, UK) is used to determine physical activity. By registering the intensity and duration of each category of activities, the system adds the energy estimated to generate a value that reflects the total energy expenditure. | 14 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Short bowel syndrome, Energy metabolism, Stable isotopes, Doubly labeled water