Serum Regucalcin Level and Chronic Hepatitis B

Study Overview
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Brief Summary
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This study, it was aimed to investigate the relationship between serum regucalcin level and liver fibrosis level in patients with CHB infection.

Detailed Description
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Chronic hepatitis B (CHB) infection continues to be an important health problem due to its high morbidity and mortality. For this reason, it is very important to determine the appropriate timing to start antiviral therapy in patients with CHB infection and to evaluate the stage of liver fibrosis in the treatment follow-up. Liver biopsy is the gold standard for detecting liver fibrosis. Although it is generally accepted to be a safe procedure, it can cause some serious complications. For this reason, in recent years, many studies have been conducted on new noninvasive tests in the evaluation of liver fibrosis. One of them is the serum regucalcin level. Studies have shown that serum regucalcin levels increase in liver damage, but there is no study in the literature comparing liver fibrosis and serum regucalcin levels in CHB infection. This study, it was aimed to investigate the relationship between serum regucalcin level and liver fibrosis level in patients with CHB infection.

Official Title
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Efficacy of Serum Regucalcin Level in Detecting Fibrosis in Chronic Hepatitis B Infection

Conditions
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Chronic Hepatitis b, Liver Fibrosis

Intervention / Treatment
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* Diagnostic Test: Serum regucalcin level


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Being followed up with a diagnosis of chronic hepatitis B Not having a known history of liver disease who applied to our outpatient clinic for other reasons Having a liver biopsy ≥18 years Exclusion Criteria: <18 years

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Interventional Model Description: Patients undergoing liver biopsy for chronic hepatitis b
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Chronic Hepatitis B<br>Measurement of serum regucalcin level | Diagnostic Test: Serum regucalcin level<br>* During routine outpatient controls, serum regucalcin level will be measured from the rest of the blood taken for examinations.<br>|
| Other: Healthy Volunteers<br>Measurement of serum regucalcin level | Diagnostic Test: Serum regucalcin level<br>* During routine outpatient controls, serum regucalcin level will be measured from the rest of the blood taken for examinations.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of serum regucalcin levels with liver fibrosis levels | We grouped chronic hepatitis b patients as mild fibrosis (stage 1-2) and moderate fibrosis (stage 3-4) according to the fibrosis stage at liver biopsy stage. We selected healthy volunteers without liver disease as the control group. We will measure the serum regucalcin level in these 3 groups and make a comparison between the groups. We want to show the relationship between serum regucalcin level and fibrosis level in chronic hepatitis b. | Performing liver biopsies: 3 months, data collection: 1 month, writing the article: 1 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hepatitis b, fibrosis, regucalcin, liver