Acute Cholecystitis: Early Versus Delayed Laparoscopic Cholecystectomy; Randomized Prospective Study

Study Overview
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Brief Summary
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The best management of the acute cholecystitis is to do laparoscopic cholecystectomy. The hypothesis is that to do it as an early intervention after patient admission is better than delayed cholecystectomy regarding the hospital stay, interval for antibiotic, the easiness of the operative maneuver reflected by operative time, conversion and intraoperative complications.

Detailed Description
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Doing laparoscopic cholecystectomy for patients with acute cholecystitis as an early intervention after patient admission ( first group) or to do it after a while of treatment and conservation as a delayed cholecystectomy (second group) points of study include the hospital stay, interval for antibiotic, the easiness of the operative maneuver reflected by operative time, conversion and intraoperative complications.

Official Title
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Acute Cholecystitis: Early Versus Delayed Laparoscopic Cholecystectomy; Randomized Prospective Study

Conditions
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Acute Cholecystitis

Intervention / Treatment
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* Procedure: Early cholecystectomy
* Procedure: Delayed cholecystectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Proved acute cholecystitis clinical, radiologic Exclusion Criteria: Evidence of peritonitis ASA III or IV Previous upper abdominal surgery Pregnancy
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Early cholecystectomy<br>Laparoscopic cholecystectomy well be done after the immediate admission | Procedure: Early cholecystectomy<br>* Early laparoscopic cholecystectomy for acute cholecystitis after admission<br>* Other names: First group;|
| Active Comparator: Delayed cholecystectomy<br>Laparoscopic cholecystectomy after a period of conservative treatment | Procedure: Delayed cholecystectomy<br>* Laparoscopic cholecystectomy well be done after a period on conservation<br>* Other names: Second group;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Operative time | Operative time is assessed in minutes , | 1 DAY | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Perioperative complications | Intraoperative complications like bleeding , injury, | 5 weeks | 
| Conversion rate | Conversion rate from laparoscopic to open and reason of conversion. | 1 DAY | 
| hospital stay in days | hospital stay in days | 2 weeks | 
| Period of giving antibiotics in days | Number of days giving the antibiotics | 2 WEEKS | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Laparoscopic cholecystectomy, Acute cholecystitis, Early, Delayed