PANCREATIC CANCER: DYNAMIC ASSESSMENT AT ALL STAGES OF TREATMENT

Study Overview
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Brief Summary
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The study consists of a 25 ml blood sample collection: Before the start of treatment Approximately 2 months after the start of induction chemotherapy At the end of induction chemotherapy Prior to local treatment (radiotherapy, surgery) At the time of tumor progression Collection of tumor material: During the initial diagnostic biopsy On the operating room in case of surgery At tumor biopsy in case of recurrence or progression (optional) As well as the completion of a questionnaire at inclusion.

Official Title
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PANCREATIC CANCER: DYNAMIC ASSESSMENT AT ALL STAGES OF TREATMENT: PANDORE-PANC-IPC 2021-082

Conditions
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Pancreatic Cancer Non-resectable

Intervention / Treatment
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* Other: collection of blood and tumor samples


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Non-metastatic pancreatic adenocarcinoma that is not immediately resectable (borderline and locally advanced tumors according to the NCCN 2020 classification) No previous treatment with surgery or chemotherapy Age > 18 years General condition WHO 0-2 (patient whose general condition can allow medical treatment or surgery) Therapeutic management at the Paoli-Calmettes Institute Signature of the informed consent specific to the PANDORE-PANC study Patient affiliated to a social security system or benefiting from such a system Exclusion Criteria: Metastatic disease Pancreatic tumor of a histological type other than adenocarcinoma Other tumor under treatment or for which treatments have been completed for < 1 year Pregnant or breastfeeding women Person in an emergency situation Person of legal age under legal protection (guardianship, curatorship or safeguard of justice) or unable to give consent.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: collection of blood and tumor samples<br> | Other: collection of blood and tumor samples<br>* The study consists of the collection of a 25 ml blood sample: Before the start of treatment Approximately 2 months after the start of induction chemotherapy At the end of induction chemotherapy Prior to local treatment (radiotherapy, surgery) At the time of tumor progression At the time of collection of tumor material: During the initial diagnostic biopsy On the operating room in case of surgery During a tumor biopsy in case of recurrence or progression (optional) and a questionnaire evaluating the patient's spontaneous physical activities.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Predict response to systemic therapies in patients with non-metastatic pancreatic adenocarcinoma | Analysis of the impact of identified biomarkers on overall patient survival and tumour response | up to 6 years |