Umbilical Cord Mesenchymal Stem Cells Infusion Via Hepatic Artery in Cirrhosis Patients

Study Overview
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Brief Summary
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The purpose of this study is to investigate the efficacy of umbilical cord mesenchymal stem cells (MSCs) infusion via hepatic artery in the treatment of liver cirrhosis.

Detailed Description
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To investigate the efficacy of umbilical cord mesenchymal stem cells (MSCs) infusion via hepatic artery in the treatment of liver cirrhosis. Patients with liver cirrhosis were randomly separated into two groups. Umbilical cord MSCs were infused to patients using interventional method via hepatic artery for One group. After the catheter placed at proper hepatic artery was confirmed by angiography, umbilical cord MSCs were infused slowly for 15-20minutes. The control group accepted conserved therapy.

Official Title
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The Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cells Infusion Via Hepatic Artery in Cirrhosis Patients.

Conditions
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Liver Cirrhosis, Radiology, Mesenchymal Stem Cells, Umbilical Cord

Intervention / Treatment
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* Biological: umbilical cord Mesenchymal Stem Cells
* Drug: Conserved therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged 18 70 years. Liver cirrhosis written consent Exclusion Criteria: The end-stage of liver cirrhosis. Severe problems in other vital organs(e.g.the heart,renal or lungs). Hepatocellular carcinoma or other malignancies Pregnancy sepsis Presence of significant extrahepatic biliary disease (e.g. CBD stone, PSC, etc.) Cardiac, renal or respiratory failure Active thrombosis of the portal or hepatic veins

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: umbilical cord mesenchymal stem cells<br>Umbilical cord mesenchymal stem cells were infused to patients using interventional method via hepatic artery. After the catheter placed at proper hepatic artery was confirmed by angiography,umbilical cord MSCs were infused slowly for 15-20minutes. | Biological: umbilical cord Mesenchymal Stem Cells<br>* Umbilical cord mesenchymal stem cells were infused to patients using interventional method via hepatic artery. After the catheter placed at proper hepatic artery was confirmed by angiography,umbilical cord MSCs were infused slowly for 15-20minutes.<br>* Other names: Mesenchymal Stem Cells;|
| Active Comparator: Conserved therapy<br>Patients received comprehensive treatment including antiviral drugs, lowering aminotransferase and jaundice medicine. | Drug: Conserved therapy<br>* Oral or intravenous administration<br>* Other names: Drug therapy;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The result of liver function and liver histological improvement. |  | every 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The disappearance or reduction of abdominal dropsy |  | every 4 weeks | 
| The clinical symptom improve(including food appetite,debilitation,abdominal distension,edema of lower limbs ) |  | every 4 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Liver cirrhosis, Radiology, Mesenchymal Stem Cells, Umbilical Cord