Multimodal Imaging Analysis, SD-OCT and OCT Angiography, Retinal Variations Observed in Dialysis Patients

Study Overview
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Brief Summary
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Little knowledge exist on the short and long-term ophthalmological effect of the dialysis. Some studies stated a variation of the thickness subfoveal choroidal before and after a session of dialyse as well as variations of the coat of optical fibers measured in OCT. The Optical Coherence Tomography angiography OCT is a not invasive imaging technique which is now a part of examinations of investigation in imaging of retina. This technique allows to study the retinal macula vascularization without injection of contrast agent and thus allows to deepen the knowledge in medical domains where the exploration was to limited because of the invasive character of the examinations. The hypothesis of this project is that hemodynamic change during the hemodialysis may lead fine variations of the retinal vascularization in the short-term (the day of the dialysis) but also in the longer term (over 1 year).

Official Title
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Multimodal Imaging Analysis, SD-OCT and OCT Angiography, Retinal Variations Observed in Dialysis Patients

Conditions
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Renal Failure

Intervention / Treatment
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* Other: Multimodal Imaging Analysis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Indication of treatment by hemodialysis First session of dialysis Hemodialysis planned for 1 minimum year Exclusion Criteria: particular ophthalmological Histories: vitreo-retinal surgery, strong nearsightedness, chronic glaucoma Unaffiliated in a national insurance scheme

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Multimodal Imaging Analysis|The patients are seen in consultation ophthalmological before and the 1 hour after their session of dialysis. THE OCT angiography and other not invasive ophthalmological examinations will be realized during the follow-up|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| vascular density before hemodialysis | Analysis of the variation of the vascular densities in retinal macula in the central 6 mm | before hemodialysis | 
| vascular density 1 hour after hemodialysis | Analysis of the variation of the vascular densities in retinal macula in the central 6 mm | 1 hour after hemodialysis | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| vascular density 1 month after dialysis | Analysis of the variation of the vascular densities in retinal macula in the central 6 mm | 1 month after dialysis | 
| vascular density 3 month after dialysis | Analysis of the variation of the vascular densities in retinal macula in the central 6 mm | 3 month after dialysis | 
| vascular density 6 month after dialysis | Analysis of the variation of the vascular densities in retinal macula in the central 6 mm | 6 month after dialysis | 
| vascular density 12 month after dialysis | Analysis of the variation of the vascular densities in retinal macula in the central 6 mm | 12 month after dialysis | 
| vascular density before dialysis | mesure by OCTA | before dialysis | 
| vascular density 1 hour after dialysis | mesure by OCTA | 1 hour after dialysis | 
| vascular density 1 month after dialysis | mesure by OCTA | 1 month after dialysis | 
| vascular density 3 month after dialysis | mesure by OCTA | 3 month after dialysis | 
| vascular density 6 month after dialysis | mesure by OCTA | 6 month after dialysis | 
| vascular density 12 month after dialysis | mesure by OCTA | 12 month after dialysis | 
| size of coat retinal optical fibers before dialysis | variation of the coat | before dialysis | 
| size of coat retinal optical fibers 1 hour after dialysis | variation of the coat | 1 hour after dialysis | 
| size of coat retinal optical fibers 1 month after dialysis | variation of the coat | 1 month after dialysis | 
| size of coat retinal optical fibers 3 month after dialysis | variation of the coat | 3 month after dialysis | 
| size of coat retinal optical fibers 6 month after dialysis | variation of the coat | 6 month after dialysis | 
| size of coat retinal optical fibers 12 month after dialysis | variation of the coat | 12 month after dialysis |