C1q/TNF-related Proteins in Coronary Artery Disease

Study Overview
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Brief Summary
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Now, adipose tissue is established as an active endocrine organ that controls systemic energy homeostasis by secretion of adipokines. Recently, members of the C1q/tumor necrosis factor-related protein (CTRP) family have been reported to share structural homology with adiponectin. To date, 15 CTRP family members have been found that might play major roles in metabolism and inflammation. The investigators tried to clarify the relationship between CTRP family and coronary artery disease (CAD) in Korean men and women.

Detailed Description
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Adipose tissue secretes various kinds of bioactive molecules termed adipokines which contribute to the development of obesity-related disorders including cardiovascular disease (CVD). Adiponectin is the insulin-sensitizing adipokine with anti-inflammatory and anti-atherogenic properties. Hypoadiponectinemia has been associated with an increased risk of coronary artery disease (CAD) in several though not all studies. Recently, a new family of secreted proteins, C1q/TNF-related protein (CTRP), was cloned on the basis of sequence homology with adiponectin. This family of adiponectin paralogs might have pivotal implications in energy homeostasis and obesity-related inflammation. Each CTRP family member has its own unique tissue expression profile and function in regulating glucose and/or fat metabolism. In the present study, we evaluated the role of CTRP in patients with CAD and investigated whether CTRP family is significantly associated with CAD prevalence after adjustment for well-known CAD risk factors.

Official Title
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C1q/TNF-related Proteins in Coronary Artery Disease

Conditions
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Coronary Artery Disease (CAD)

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 20<age<80 History of stable angina, unstable angina, or acute myocardial infarction Exclusion Criteria: a history of diabetes stage 2 hypertension malignancy severe renal or hepatic disease

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with CAD<br>Acute coronary syndromoe (ACS) patients who were admitted to the coronary care unit. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| serum concentration of CTRP-1,3, or 9 in the subjects with/without CAD | compare serum concentration of CTRP-1,3 or 9 between CAD patients and normal group | at enrollment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The relationships of serum CTRPs/adiponectin levels with cardiometabolic risk profiles | find the correlation of CTRPs and adiponection with cardiometabolic risk | at enrollment |