The Need of Revisiting to an Outpatient Clinic After the Prescription of Vonoprazan or Esomeprazole

Study Overview
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Brief Summary
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After vonoprazan (20mg/day) or esomeprazole (20mg/day) for 4weeks is prescribed for patients with erosive esophagitis diagnosed by esophagogastroduodenoscopy, the number of patients who will visit our outpatient clinic again due to some reasons without any appointments is compared with vonoprazan group and esomeprazole.

Detailed Description
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Patients who have erosive esophagitis diagnosed by esophagogastroduodenoscopy is enrolled. Vonoprazan (20mg/day) or esomeprazole (20mg/day) is prescribed for 4weeks the patients randomly without next appointments. Some patients may visit our outpatient clinic again due to some reasons without any appointments. The number of the patients who revisit our outpatient clinic again is compared with vonoprazan group and esomeprazole.

Official Title
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The Need of Revisiting to an Outpatient Clinic After the Prescription of Vonoprazan or Esomeprazole for 4weeks for Erosive Esophagitis Without Any Appointments

Conditions
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Gastroesophageal Reflux

Intervention / Treatment
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* Drug: Vonoprazan
* Drug: Esomeprazole


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: outpatients belonging to American Society of Anesthesiologists class I or II patients have erosive esophagitis diagnosed by esophagogastroduodenoscopy shortly before the prescription Exclusion Criteria: other acid blockers are taken

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Vonoprazan<br>Vonoprazan (20mg/day) is prescribed for patients with erosive esophagitis | Drug: Vonoprazan<br>* Vonoprazan (20mg/day) is prescribed for 4 weeks.<br>* Other names: Esomeprazole;|
| Placebo Comparator: Esomeprazole<br>Esomeprazole (20mg/day) is prescribed for patients with erosive esophagitis | Drug: Esomeprazole<br>* esomeprazole (20mg/day)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The number of patients who revisit our outpatient clinic after the prescription without any appointments | The need to revisit our outpatient clinic again without any appointments may show the patients' satisfaction or dissatisfaction after the prescription of vonoprazan or esomeprazole. The difference in the number between the two groups may show the difference in the effectiveness between the two medicines. | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of the main symptom with patients after/before medication when the patients revisit again | The ratio of the degree of the main symptom after/before taking the medicine Good 0%- Bad 100% | 3 months |