Effects of Sleep Privation on Sensorimotor Integration of the Upper Limb During a Manual Endurance Test in Healthy Volunteers-Physiological Study

Study Overview
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Brief Summary
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The investigator showed that a night of sleep deprivation halved the duration of an inspiratory endurance test and that this loss of endurance could be secondary to a lack of activation of the pre-motor cortex. However, the inspiratory endurance test is associated with a feeling of dyspnea that could lead to premature arrest, and the inspiratory drive is complex, both automatic and voluntary. The investigator can reproduce this results on a simpler drive. During the execution of an exercise involving repeated contractions of the hand it is possible to record the activation of the pre-motor cortex corresponding to the phase of preparation of the movement. The amplitude of these premotor potentials is proportional to the developed motive force. The purpose of this study is to assess the impact of sleep deprivation on the muscular endurance of non-dominant in healthy subjects. Hypothesis: Sleep deprivation causes a decrease in manual motor endurance by decreasing cortical pre-motor control. Main objective: To compare the motor endurance of healthy subjects after a night's sleep and after a sleepless night. Secondary objective: To compare the amplitude of premature cortical control at the beginning of the endurance test after a night's sleep and after a sleepless night.

Official Title
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Effects of Sleep Privation on Sensorimotor Integration of the Upper Limb During a Manual Endurance Test in Healthy Volunteers-Physiological Study

Conditions
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Sleep Deprivation, Healthy Volunteers, Skeletal Muscle

Intervention / Treatment
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* Behavioral: Normal sleep night
* Behavioral: Sleepless night


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adult male volunteers; 25 to 45 years old regularly sleeping more than 6 hours per night; no excessive consumers of coffee (<3 espressos / day); absence of muscular or neurological pathology ; with a BMI> 18 and <25 kg / m²; Horne and Ostberg score> 31 and <69 ; Exclusion Criteria: female sex history of neuromuscular disease ; implanted metallic or electronic equipment (vascular stent, ocular implant, pacemaker ...) history of epilepsy, or discomfort after sleep deprivation ; poor sleepers (PSQI> 5); exercising an activity in staggered hours; regularly performing more than 2 nights without sleep per month; taking drugs interfering with sleep (antidepressants, benzodiazepines ...); having crossed 4 time zones in the previous 4 weeks. current participation in another clinical research study;

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: To compare the motor endurance of healthy subjects after a normal sleep night and after a sleepless night.
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sham Comparator: Normal sleep night<br>The first endurance test is the endurance motor control test after a normal sleep night. | Behavioral: Normal sleep night<br>* Usual hours of sleep<br>|
| Experimental: Sleepless night<br>The first endurance test is the endurance motor test after a sleepless night. | Behavioral: Sleepless night<br>* Total sleep deprivation the first night<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Test duration | Time, in minutes, measured between the beginning of the endurance test and the end of the test, defined by the volunteer's inability to maintain a force of at least 30% of the maximum strength for 5 seconds. | 1 hour. |