linjc16/ctgov huggingface dataset:
A Comprehensive Prospective Assessment of the Physical and Biological Effects of Upper Tract Urothelial Cancer (UTUC)

Study Overview
=================
Brief Summary
-----------------
There are many controversies and limitations in the management of Upper Tract Urothelial cancer. A prospective registry is set up for patients in our hospital, aim to have a comprehensive prospective assessment of the physical and biological effects of Upper Tract Urothelial cancer in our patients

Detailed Description
-----------------
Although Upper Tract Urothelial Carcinoma (UTUC) is relatively uncommon, the incidence rate is increasing. There are many controversies and limitations in the management of Upper Tract Urothelial cancer. In this study, investigators would like to establish a local registry for upper tract urothelial cancer to facilitate the collection of clinical information and outcomes of upper tract urothelial cancer management, and to collect blood, urine and tumour tissue samples to investigate for new diagnostic and therapeutic agents. Hopefully, our registry can provide information regarding the epidemiology, natural history, and treatment outcomes of upper tract urothelial cancer in Hong Kong.

Official Title
-----------------
A Comprehensive Prospective Assessment of the Physical and Biological Effects of Upper Tract Urothelial Cancer (UTUC)

Conditions
-----------------
Upper Tract Urothelial Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male patients > 18 years old Patients who has presence of UTUC and pending for surgery Patients who has history of UTUC with any intervention performed Exclusion Criteria: - Patients fail to provide informed consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Long-term survival | Long-term survival | 10 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recurrence rate of UTUC | Recurrence rate of UTUC | 10 years | 
| Progression rate of UTUC | Progression rate of UTUC | 10 years | 
| Complications | Complications are assessed by medical record and on patient follow up | 10 years |
Evaluation of Colorectal Cancer Screening Strategies in China

Study Overview
=================
Brief Summary
-----------------
A large-scale randomized controlled trial was conducted to compare different colorectal neoplasms screening strategies in China.

Official Title
-----------------
Evaluation of Colorectal Cancer Screening Strategies in China：A Prospective Randomized Trial

Conditions
-----------------
Colorectal Neoplasms

Intervention / Treatment
-----------------
* Diagnostic Test: Qualitative Fecal immunochemical test + APCS score
* Diagnostic Test: Quantitative Fecal immunochemical test


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 50-74 years old Informed consent is available Exclusion Criteria: Previous colorectal cancer Previous colorectal resection Previous received cancer-related treatment (except non-melanoma skin cancer) Colonoscopy, sigmoidoscopy, CT colonoscopy, and barium enema were performed within 5 years Fecal occult blood or fecal DNA was performed within one year Symptoms of lower digestive tract diseases requiring colonoscopy include: (1) rectal bleeding occurred more than once in the past 6 months, (2) recorded iron deficiency anemia, and (3) recorded significant weight loss within 6 months (> 10% of baseline weight - Suffering from other diseases that affect the benefit of screening or intolerance to colonoscopy (for example, severe pulmonary disease, end-stage renal disease, end-stage liver disease, severe heart failure or recently diagnosed cancer, except non-melanoma skin cancer)

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 74 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Risk score1<br> | Diagnostic Test: Qualitative Fecal immunochemical test + APCS score<br>* Risk stratification using Qualitative Fecal immunochemical test and APCS score<br>|
| Active Comparator: Risk score2<br> | Diagnostic Test: Quantitative Fecal immunochemical test<br>* Use Quantitative Fecal immunochemical only for risk stratification<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Detection rate | Detection of intestinal lesions | up to 30 months |
Effects of Laugh-yoga Intervention on Mood and Quality of Life Among Oncologic Patients in a Oncologic Clinic Setting.

Study Overview
=================
Brief Summary
-----------------
Previous studies report low levels of mood and of quality of life among cancer patients. Laugh has been proved to improve mood and immune system function. The investigators propose to assess in a prospective randomised case-control study the affects of laugh-yoga intervention on mood levels and quality of life among cancer patients in a cancer clinic. The main hypothesis is that patients in laugh-yoga group will report higher mood and quality o life levels after intervention in comparison with no-intervention group. The second hypothesis is that immune system is the mediator of the effects of laugh-yoga intervention on mood and quality of life.

Official Title
-----------------
Effects of Laugh-yoga Intervention on Mood and Quality of Life Among Oncologic Patients

Conditions
-----------------
Neoplasms

Intervention / Treatment
-----------------
* Other: Laugh Yoga


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: oncologic patients treated in oncologic clinic in Wolfson MC, must be able to participate in Laugh Yoga session Exclusion Criteria: psychiatric or cognitive impairment, deterioration in physical status, treatment discontinuation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Laugh yoga<br>experimental laugh yoga | Other: Laugh Yoga<br>* 1 hour including laugh, respiratory exercises and guided imagination by a group instructor specialized in laugh yoga<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of Life Questionnaire - QLQ-C30 & Positive-Negative Affect |  | Participants will fill QLQ-C30 & Positive -Negative Affect will be assessed before intervention and after three laugh - yoga sessions (that is after three weeks) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood analysis for WBC, CRP, T&B Lymphocytes |  | Before intervention and after three laugh-yoga interventions, that is after three weeks. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Neoplasm, Laugh-Yoga, Mood, Quality of life
Quantitative Immunochemical Fecal Occult Blood Test in Symptomatic Patients

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to compare the outcome of three (3) quantitative immunochemical faecal occult blood test in symptomatic patients.

Detailed Description
-----------------
Consecutive patients referred from primary care for colonoscopy due to symptoms are eligible. Patients will receive written information of the study together with the time for colonoscopy. A specific research nurse will call them and for those accepting participation, history and current medication will be collected. Kits will be sent to patients and they will provide three faecal samples before examination. These will be analysed at one certified laboratory. Hemoglobin concentration will be notified in the range of 50 - < 1000 ng/mL, or as a negative outcome. Macroscopic findings at the colonoscopy will be collected, as well as the outcome of the pathological report.

Official Title
-----------------
Quantitative Immunochemical Fecal Occult Blood Test in Symptomatic Patients

Conditions
-----------------
Colorectal Neoplasms

Intervention / Treatment
-----------------
* Device: fecal occult blood test


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Symptoms associated with colorectal cancer (anemia, change of bowel habits, diarrhoea, constipation, haematochezia, weight loss, anorexia) Exclusion Criteria: Screening investigations High-risk patients

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: fecal occult blood test|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with high fecal blood output in relation to colorectal cancer | Accuracy of diagnosis in colorectal cancer | Up to 36 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with low fecal blood output in relation to colorectal polyps | Accuracy of diagnosis of colorectal polyps | Up to 36 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
fecal occult blood
Comparing Weaning of Nasal Continuous Positive Airway Pressure (CPAP) From Preterm Infants

Study Overview
=================
Brief Summary
-----------------
To compare the 2 methods of weaning of nasal continuous positive airway pressure (CPAP) in premature babies born between 26 and 32 weeks

Detailed Description
-----------------
To study the weight and the post menstrual age (PMA) at the time of NCPAP wean utilizing the method of sudden wean as compared to gradual wean. Methods: A prospective randomized trial was conducted comparing sudden weaning with gradual weaning from NCPAP in neonates with gestational age between 26 and 32 weeks. The patients were randomized to one of the two methods of weaning from NCPAP and their success was compared

Official Title
-----------------
Randomized Control Trial of Weaning NCPAP From Preterm Infants: Sudden Wean Versus Weaning by Gradually Decreasing Pressure

Conditions
-----------------
Respiratory Distress Syndrome

Intervention / Treatment
-----------------
* Other: Gradual pressure wean


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All neonates born 26 to 32 weeks of gestational age Exclusion Criteria: Those with severe congenital anomalies and chromosomal defects including congenital heart disease, neurological malformations, chest and airway abnormalities and lung hypoplasia

Ages Eligible for Study
-----------------
Minimum Age: 26 Weeks
Maximum Age: 32 Weeks

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Sudden wean<br>When ready Nasal Continuous Positive Airway Pressure (NCPAP) will be removed from the neonate | |
| Active Comparator: Gradual pressure wean<br>NCPAP will be removed by gradually decreasing pressure over 24 hours once the weaning is decided | Other: Gradual pressure wean<br>* NCPAP will be removed by gradually decreasing pressure over 24 hours once the weaning is decided<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Success of weaning on first trial off NCPAP |  | Completion of Nasal Continuous Positive Airway Pressure (NCPAP) treatment, expected average of 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Weight and corrected GA when come off oxygen |  | when off supplemental oxygen expected average of 2 weeks | 
| Weight and corrected gestational age (GA) when neonates could come off NCPAP |  | Completion of Nasal Continuous Positive Airway Pressure (NCPAP) treatment, expected average of 4 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
weaning, NCPAP, Preterm, sudden wean, gradual pressure off wean
Training-induced Cerebral Reorganization in Schizophrenia

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to reveal the effects of computer-aided cognitive-auditory training on cerebral reorganization in schizophrenia.

Detailed Description
-----------------
Impairment in cognitive functions is one of the main symptoms in schizophrenia and is currently one of the challenges in the treatment of the disease. In this study we compare effects of two computer-aided training programs. One focused on auditory perception and processing as a basic ability underlying higher order information processing. The other training involves a variability of cognitive abilities. Both trainings are computer-aided and time-intensive, including up to twenty sessions within four weeks.

Official Title
-----------------
Training-induced Cerebral Reorganization in Schizophrenia

Conditions
-----------------
Schizophrenia

Intervention / Treatment
-----------------
* Behavioral: Brain Fitness Program
* Behavioral: Cogpack


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical diagnosis of schizophrenia and disorders with psychotic features Intact hearing abilities Exclusion Criteria: Mental retardation Age over 60 Insufficient German language knowledge

Ages Eligible for Study
-----------------
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: BFT<br>20 schizophrenic patients | Behavioral: Brain Fitness Program<br>* Computer-aided cognitive program designed for intensive training of auditory perception, memory and attention<br>|
| Active Comparator: CP<br>19 schizophrenic patients | Behavioral: Cogpack<br>* Computer-aided cognitive program for cognitive abilities<br>|
| No Intervention: HCG<br>20 healthy age and sex matched subjects | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Event related potential MEG, test scores in word fluency and verbal learning tasks |  | pre and post intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Symptom severity, GAF score |  | pre and post intervention | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
schizophrenia, neuroplasticity, sensory gating, cognitive impairment, MEG, Disorders with Psychotic Features
Characteristics of Persons With an Eating Disorder and Type 1 Diabetes

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to analyze a chart audit of patients seen at Park Nicollet Eating Disorder Institute (EDI) to identify and compare general characteristics of eating disorders with type 1 diabetes patients to a matched eating disordered population without type 1 diabetes, also seen at EDI.

Detailed Description
-----------------
The goal of this study is to conduct a chart audit on all patients with type 1 diabetes who have been seen collaboratively by International Diabetes Center (IDC) and Park Nicollet Eating Disorder Institute (EDI) staff from 2005 - 2008 and their matched eating disordered controls. Research Questions What are the general characteristics of the ED DM T1 population? How are ED DM T1 patients different from the matched eating disordered patients with respect to race, marital status, age of onset, eating behaviors, self-reported highest and lowest weight, exercise frequency and duration, number of hospital admissions, number of emergency room visits, medication needs, and other medical and psychological/psychiatric comorbidities? How are ED DM T1 patients different from the matched eating disordered patients with respect to the affective and cognitive aspects of eating disorders such as self-reported depression symptoms, body image distortion, thoughts and feelings about eating, psychological concerns, readiness to change, self-esteem and anxiety? For ED DM T1 patients, what is the time relationship of the diagnosis of diabetes and an eating disorder? For ED DM T1 patients, what is the relationship of BMI and A1c?

Official Title
-----------------
Characteristics of Persons With an Eating Disorder and Type 1 Diabetes and Psychological Comparisons to Persons With an Eating Disorder and No Diabetes

Conditions
-----------------
Eating Disorder, Type 1 Diabetes

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patient seen in both Park Nicollet Eating Disorder Institute and International Diabetes Center for type 1 diabetes from 2005 - 2008 patient seen only in Park Nicollet Eating Disorder Institute from 2005 - 2008 Exclusion Criteria: none
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Eating Disorder Diabetes Mellitus T1 patients | |
| 2<br>Eating Disorder only patients | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| define general characteristics of the diabetes and eating disorder population |  | 2005 - 2008 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
dual diagnosis
Propolis In The Treatment Of Periodontitis

Study Overview
=================
Brief Summary
-----------------
This study was conducted to evaluate by clinical and microbiological parameters the effect of locally delivered propolis as an adjunct to scaling and root planing in the treatment of chronic periodontitis.

Detailed Description
-----------------
Materials and Methods: 20 subjects diagnosed with chronic periodontitis were recruited to participate in split-mouth design and provided informed consent. Subgingival plaque sampling and clinical recording at baseline, 15 days and 1 month was performed. The patients received scaling and root planing, followed by Propolis administration subgingivally in the test sites. Significant differences between test and control were evaluated using the Mann-Whitney U test and Wilcoxon rank test.

Official Title
-----------------
Propolis In The Treatment Of Chronic Periodontitis - A Clinicomicrobiologic Study

Conditions
-----------------
Chronic Periodontitis

Intervention / Treatment
-----------------
* Procedure: scaling root planing
* Drug: Propolis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: good general health chronic periodontitis minimum of 20 natural teeth with at least one pocket per quadrant probing depth (PD) between 5 and 8 mm. Exclusion Criteria: subgingival instrumentation within 3 months antibiotic therapy within 3 months prior to the start of the study; smokers pregnant or nursing women intolerance or allergy to honey products

Ages Eligible for Study
-----------------
Minimum Age: 25 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Propolis<br> | Procedure: scaling root planing<br>* scaling root planing<br>Drug: Propolis<br>* experimental<br>|
| Sham Comparator: scaling and root planing<br> | Procedure: scaling root planing<br>* scaling root planing<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in the probing pocket depth and clinical attachment level |  | three time points of baseline,2 weeks, 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in gingival index and microbiological changes |  | three time points baseline, 2 weeks, 4 weeks. |
Effect of the Intra-abdominal Pressure on the Risk of Delirium in Mechanically Ventilated Patients.

Study Overview
=================
Brief Summary
-----------------
intra-abdominal hypertension (IAH) and delirium are serious, high-frequency complications in intensive care unit (ICU) patients. The consequences of the complication range from high morbidity and mortality to a greater need for nursing care. We hypothesize that there could be a correlation between IAH and incidence of delirium.

Official Title
-----------------
Effect of the Intra-abdominal Pressure on the Risk of Delirium in Mechanically Ventilated Patients.

Conditions
-----------------
Delirium, Intraabdominal Hypertension, Mechanical Ventilation Complication

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients of both genders on mechanical ventilation Exclusion Criteria: age under 18 years, use of muscle relaxants, abdominal operation within the previous 3 months, acute peritonitis, and abdominal mass, acute injury to the urinary bladder, acute cystitis, neurogenic bladder, pelvic hematoma, and pelvic fracture.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| delirium | NEECHAM confusion scale will be used | 3 days |