Neurophysiological Attention Test (NAT) for Objective Assessment of Adult ADHD

Study Overview
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Brief Summary
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The purpose of this study is to refine a new assessment tool for Attention Deficit/Hyperactivity Disorder (ADHD) and then to test its validity (i.e. ability to discriminate between individuals with ADHD and healthy controls.

Detailed Description
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The purpose of this study is to build upon the success the novel approach and software for analyzing electroencephalography (EEG) data to identify biomarkers of ADHD in adults by further refining the method. Then to test the ability of this new assessment tool to differentiate between adults with ADHD and healthy controls by comparing the classification accuracy of the metrics from the new tool to the classification accuracy of existing behavioral tests for ADHD.

Official Title
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Neurophysiological Attention Test (NAT) for Objective Assessment of Adult ADHD

Conditions
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Attention Deficit Hyperactivity Disorder

Intervention / Treatment
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* Other: NAT electroencephalography (EEG) test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Specific inclusion criteria for ADHD are: meet established Diagnositic and Statistical Manual-5 criteria for ADHD predominately inattentive or combined subtype with clinically significant levels of impairment, diagnosed by structured clinical interview, the Mini International Neuropsychiatric Interview, and corroborating information Clinical Global Impression-Severity (CGI-S) score ≥ 4 for ADHD no lifetime history of DSM-5 bipolar disorder, psychotic disorder, pervasive developmental disorder, obsessive-compulsive disorder, substance abuse, or substance dependence (except nicotine) as assessed with the Mini International Neuropsychiatric Interview (MINI). able in the opinion of the investigator to complete all required study procedures. Exclusion Criteria: Exclusion criteria for both groups are: History of diagnosis of childhood disorder other than ADHD (e.g. autism, dyslexia) history of any general medical condition likely to require chronic use of medication with identified central nervous system (CNS) effects suspected to alter cognitive performance history of seizure disorder, brain tumor, other major neurological disorder or head injury resulting in loss of consciousness serious oxygen deprivation current psychopathology requiring ongoing treatment with antipsychotic medications, mood stabilizers, benzodiazepines, or anticonvulsants current untreated psychopathology which is rated to be primary in terms of severity (greater than ADHD severity) current treatment with guanfacine.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| ADHD: Adults with ADHD<br>NAT electroencephalography (EEG) test | Other: NAT electroencephalography (EEG) test<br>* Individuals in both groups are asked to perform standard behavioral tests and an electroencephalography (EEG) test.<br>|
| Controls: Healthy adults without ADHD<br>NAT electroencephalography (EEG) test | Other: NAT electroencephalography (EEG) test<br>* Individuals in both groups are asked to perform standard behavioral tests and an electroencephalography (EEG) test.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| NAT Slow Fluctuation Test and Retest to assess change for Test Replicability | The NAT EEG test simultaneously generates 2 EEG values and 1 behavioral value that are used together as an assessment metric for ADHD. This is a one-time measure to assess its magnitude in ADHD vs Control. | A single measurement is made for each individual at DAY 1 - the time of the brain wave (EEG) test; and a single measure is made again in each individual at least 30 days later (DAY 2) to identify any differences, to assess replicability of the measure. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Electroencephalography, Attention