Alcohol Detection Via Bioimpedance Mesurements

Study Overview
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Brief Summary
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Examination if the bioimpendanz measurement can be used for the determination of the alcohol content in human blood. Furthermore the blood alcohol content (BAC) will be estimated by an official breathalyzer and one blood test.

Detailed Description
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In this clinical trail it will be analyzed, if it is possible to assess the blood alcohol content (BAC) with the bioimpedance devices (SFB7, ImpediMed; Nicomo). This technology is non-invasive an can be measured by using conductive electrodes, capacitive electrodes or inductive measurement systems. The BIS-values will be compared with an official breathanalyzer (Alcotest 7110 Evidential MK III, Dräger, Lübeck, Germany). Furthermore one blood sample will be taken and analyzed with the ADH method as the current gold standard at the end of the trail.

Official Title
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Alcohol Detection Via Bioimpedance Mesurements

Conditions
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Healthy

Intervention / Treatment
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* Device: bioimpedance mesurements


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy male subjects able to give informed consent Inconspicuous laboratory and drug screening Exclusion Criteria: electrophobica alcoholphobica, -allergy metallic ans / or electric implants underage persons interactively medication

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| bioimpedance measurements while trinking alcohol<br>Bioimpedance spectroscopy (BIS) measurements on 12 healthy subjects were performed while they were drinking alkohol until reaching a BAC of 0.8 ‰. | Device: bioimpedance mesurements<br>* Bioimpedance measurements were conducted with a BIS device (SFB7, ImpediMed, Pinkeba, Australia) covering a frequency range between 5 kHz and 1 MHz and an ICG device (Niccomo, medis, Ilmenau, Germany)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bioimpedance measurements | Evaluation if the bioimpedance measurements can be used to verify and quantify the alcohol content in human blood. Bioimpedance measurements will be conducted with the BIS device (SFB7, ImpediMed) covering a frequency range between 5 kHz and 1 MHz and an ICG device (Niccomo,medis) operating at. The whole-body and hand-to-hand bioimpedance will be analyzed. Extracellular resistance (Re), intracellular resistance (Ri) and capacitive effects (Cm) are calculated by using the Cole model Grimnes (2000). | 4 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Impedance cardiography, bioimpedance, spectroscopy, extracellular resistance, body composition, hemodynamics, alcohol