Dietary Patterns and Cardiovascular (CVD) Risk in Spinal Cord Injury (SCI) Factors In Individuals With Chronic Spinal Cord Injury

Study Overview
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Brief Summary
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This study will look at dietary patterns in individuals with chronic spinal cord injuries and the relationship between these dietary patterns and cardiovascular disease risk factors. The study is a supplement to the Coronary Artery Risk Development in Young Adults (CARDIA) study. The dietary history from CARDIA will be used. The investigators' primary hypothesis is the following: Greater whole-grain and dietary fiber intake will be favorably associated with adiposity (BMI and WC) and metabolic CVD risk factors (fasting glucose, fasting insulin, HOMA-IR, diabetes, hsCRP, TC, HDL-C, triglycerides, TC/HDL-C ratio, non-HDL-C, and systolic and diastolic blood-pressure) among a sample of individuals with SCI aged 38-50 who have been injured >1 year.

Detailed Description
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This study is a cross-sectional study. It will look at dietary patterns in individuals with chronic spinal cord injuries and the relationship between these dietary patterns and cardiovascular disease risk factors. The study is a supplement to the Coronary Artery Risk Development in Young Adults (CARDIA) study. The dietary history from CARDIA will be used. The investigators' primary hypothesis is the following: Greater whole-grain and dietary fiber intake will be favorably associated with adiposity (BMI and WC) and metabolic CVD risk factors (fasting glucose, fasting insulin, HOMA-IR, diabetes, hsCRP, TC, HDL-C, triglycerides, TC/HDL-C ratio, non-HDL-C, and systolic and diastolic blood-pressure) among a sample of individuals with SCI aged 38-50 who have been injured >1 year.

Official Title
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Dietary Patterns & There Relationship to Cardiovascular Disease Risk Factors In Individuals With Chronic Spinal Cord Injury

Conditions
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Spinal Cord Injury

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria Male or female, black or white with SCI due to a nonvascular insult that caused an acute spinal cord injury (i.e. traumatic injury, transverse myelitis without a diagnosis of multiple sclerosis, surgical complication, or benign neoplasm) at least 1 year prior to enrollment including ASIA A,B,C Age at time of enrollment: > 38 years and <55 years (i.e., on or after 38th birthday and before 55th birthday) Voluntary, informed consent of participant Participant willing to comply with the testing protocols and questionnaires Communication and comprehension sufficient for compliance with all testing procedures and measures Exclusion Criteria SCI of a vascular or malignant etiology Pregnancy, end-stage renal disease, treatment for cancer except for non-melanoma skin cancer in the past five years Injury < 1 years prior to enrollment ASIA D Chronic, nontobacco substance-abuse

Ages Eligible for Study
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Minimum Age: 38 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Whole-grain intake | Average number of whole grain servings per day | Day - 30 | 
| Fruit and vegetable intake | Average number of fruit and vegetable servings per day | Day - 30 | 
| Dairy intake | Average number of dairy servings per day | Day - 30 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Waist circumference |  | Year 1 | 
| Total cholesterol |  | Year 1 | 
| HDL-C |  | Year 1 | 
| LDL-C |  | Year 1 | 
| Triglycerides |  | Year 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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spinal cord injury, cardiovascular disease, dietary patterns