Fitness, Activity and Lung Cancer Study

Study Overview
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Brief Summary
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The purpose of the study is to investigate the change in pulmonary function and exercise capacity in lung cancer patients after pulmonary resection. Furthermore, to study the effect of training on aerobic capacity, muscular strength, morbidity and survival. Physical activity level by accelerometers, body composition by DXA and quality of life will also be reported.

Detailed Description
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Five year after surgery, all included patients will be reinvited to undergo a fourth health excame to study the long-term effects of exercise training on physical fitness, morbidity and survival.

Official Title
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Cardiorespiratory Fitness and Effect of Training After Lung Cancer Surgery. A Randomized Controlled Trial

Conditions
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Lung Cancer

Intervention / Treatment
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* Other: Physical training
* Other: As usual


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Non smal cell lung cancer Patient living in Oslo or Akershus county and accepted for lung cancer surgery at Oslo University hospital and Akershus University hospital were able to read and speak Norwegian Exclusion Criteria: Mental incompetence or physical disability that makes it difficult to walk on a treadmill Treatment or medical complications affecting ability to participate in an exercise group > 79 years

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 79 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Physical training<br>Exercise intervention. | Other: Physical training<br>* Physical training three times a week for 20 week including endurance and strength training compare to the as usual group as controls<br>|
| Other: As usual<br>Controls | Other: As usual<br>* Controls, not training<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Maximal oxygen uptake (VO2max) from baseline | Change in VO2max from before to after surgery to measure the effect of surgery, and after six months to measure the effect of high-intensity training intervention, and after five years to study long-term effects | An expected average of two weeks before surgery (baseline), four to six weeks after surgery, after six months and after 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Pulmonary function from baseline | Change in pulmonary function from before to after surgery and after the intervention | Pulmonary function is measured three times; an expected average of two weeks before surgery, four to six weeks after surgery, after after six months and after five years. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pulmonary function, Maximal oxygen uptake, Cardiorespiratory fitness, High-intensity training, Surgery