A Dose-response Study of Lidocaine and Etomidate

Study Overview
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Brief Summary
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IV lidocaine administration can reduce the minimal amount of Etomidate and time for induction of anesthesia.

Detailed Description
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The study was carried out in West China Hospital of Sichuan University, Chengdu, China. All the patients were informed in detail about the procedure and the medications they are going to get. Patients are well informed about the beneficial and possible hazards of the medicines and procedure. Patients are also informed that they can withdraw from the study at any time if they find it uncomfortable or harmful for them. Patients' written informed consent was obtained and registered for the permission from the Hospital's Ethics Board.

Official Title
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Can Intravenous Lidocaine Decrease the Minimal Inducing Dose of Etomidate?: A Randomized Placebo-controlled Dose-response Study.

Conditions
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Etomidate Overdose of Undetermined Intent

Intervention / Treatment
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* Drug: Lidocaine 1mg/kg
* Drug: Lidocaine 1.5mg/kg
* Drug: Lidocaine 2mg/kg
* Drug: Lidocaine 2.5mg/kg


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients scheduled for Elective Surgery, age limit within 18-70 years, American Society of Anaesthesiologists physical status classification I-II Exclusion Criteria: Adrenal Cortex disorder, Neurologic disease, Psychiatric disorders, Allergic to Local anesthetic drugs, Patients who have received sedatives,analgesics or opioids within the previous 24 hrs.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Control<br>0.9% Normal Saline is given instead of Lidocaine in the same volume and duration. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex. | |
| Active Comparator: Lidocaine 1mg/kg<br>Lidocaine 1mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex. | Drug: Lidocaine 1mg/kg<br>* The total dosage of Etomidate needed for induction of anesthesia is recorded at last.<br>* Other names: serial number:11215033;|
| Active Comparator: Lidocaine 1.5mg/kg<br>Lidocaine 1.5mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex. | Drug: Lidocaine 1.5mg/kg<br>* same as other<br>* Other names: serial number:11215033;|
| Active Comparator: Lidocaine 2mg/kg<br>Lidocaine 2mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex. | Drug: Lidocaine 2mg/kg<br>* same as other<br>* Other names: serial number:11215033;|
| Active Comparator: Lidocaine 2.5mg/kg<br>Lidocaine 2.5mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex. | Drug: Lidocaine 2.5mg/kg<br>* same as other<br>* Other names: serial number:11215033;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes in blood pressure and heart rate. |  | 6 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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iv lidocaine, inducing dose, etomidate, dose response