Collagen Matrix With Tunnel Technique Compared to CTG for the Treatment of Periodontal Recessions

Study Overview
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Brief Summary
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The aim of this study is to compare the efficacy of dental root coverage using the tunnel technique with connective tissue graft (CTG) and the same technique with collagen matrix for treatment of multiple gingival recessions Miller Class I and II. This study is a randomized-controlled clinical trial of 6 months duration.

Detailed Description
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According to the medical databases, there are limited randomized clinical trials comparing xenogenic collagen matrix and CTG used with the tunnel technique. The collagen matrix is a possible alternative to connective tissue graft. The purpose of this clinical study is to compare short-term (3-6 months) outcomes of a root coverage using the tunnel technique with the collagen matrix and the same technique with CTG for the treatment of multiple recessions Miller class I and II. Twenty eight patients are enrolled in the study. Patients in the test group are treated with xenogenic collagen matrix using the tunnel technique whereas patients in the control group with CTG. Clinical recordings are obtained at baseline and after 3 and 6 months. The percentage of average recession coverage (ARC) is evaluated after 3 and 6 months after the surgery.

Official Title
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Collagen Matrix With Tunnel Technique Compared to CTG for the Treatment of Periodontal Recessions - Randomized Clinical Trial

Conditions
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Gingival Recession

Intervention / Treatment
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* Other: Surgery:The tunnel technique for covering gingival recession


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Presence of minimum two adjacent periodontal recessions Miller class I or II and at least 2 mm recessions depth. Exclusion Criteria: Approximal Plaque Index (API) > 15%, Sulcus Bleeding Index (SBI) > 10%, Systemic diseases with compromised healing potential or infectious diseases, Untreated periodontal conditions, Pregnant and lactating females.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Control group<br>Surgery:The tunnel technique for covering gingival recession. Graft: connective tissue. | Other: Surgery:The tunnel technique for covering gingival recession<br>* The surgery starts with the sulcular incisions in the region of recessions, which enable access for the supraperiosteal preparation. The procedure is extended into the mucosal tissue using the tunneling knives. The partial-thickness flap is performed at the buccal site. Only the papillary regions are fully detached with the periosteum. The graft is placed into the tunnel and stabilized with absorbable sutures.The mobilized mucous flap is advanced coronally and stabilized with non-absorbable suspensory sutures.<br>|
| Active Comparator: Study group<br>Surgery:The tunnel technique for covering gingival recession.Graft: xenogenic collagen matrix (Mucoderm). | Other: Surgery:The tunnel technique for covering gingival recession<br>* The surgery starts with the sulcular incisions in the region of recessions, which enable access for the supraperiosteal preparation. The procedure is extended into the mucosal tissue using the tunneling knives. The partial-thickness flap is performed at the buccal site. Only the papillary regions are fully detached with the periosteum. The graft is placed into the tunnel and stabilized with absorbable sutures.The mobilized mucous flap is advanced coronally and stabilized with non-absorbable suspensory sutures.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical attachment level (CAL) | Distance from the cemento enamel junction to the deepest point of the gingival sulcus | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recession depth (RD) | Distance from the mid-facial point of the cemento-enamel junction to the free gingival margin | 6 months | 
| Recession width (RW) | Recession width horizontally at cemento-enamel junction level | 6 months | 
| Width of keratinized tissue (KTW) | Distance from the mucogingival junction to the gingival margin | 6 months | 
| Recession area (RA) | The area of a triangle with a width of recession as the base and a depth of the recession as the height. | 6 months | 
| the average percentage of root coverage (ARC) | The percentage of covered recession area. | 6 months | 
| The complete coverage of recessions (CRC) | The percentage rate of patients with complete coverage of all recessions (CRC) | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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gingival recession, mucogingival surgery, collagen matrix, connective tissue graft, tunnel technique