Exercise Target Brain Oscillations in Psychosis

Study Overview
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Brief Summary
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Previous studies have shown that cardiorespiratory fitness (how well the heart and lungs are able to function during physical activity) is often reduced in people with psychosis. The goal of this research study is to test the hypothesis that aerobic exercise can lead to small changes in brain functioning that can influence visual perception and attention in psychosis. The type of aerobic exercise used in this study is called Sprint Interval Training, or SIT. Information from this study will help to develop interventions that enhance cognition and maximize the quality of life for persons living with psychosis. The exercise procedure used is called SIT, which involves training rigorously on a stationary bike for a short period of time followed by a resting period.

Official Title
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Sprint Interval Training to Target Brain Oscillations in Psychosis

Conditions
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Psychosis, Schizophrenia, Schizoaffective Disorder

Intervention / Treatment
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* Other: Sprint Interval Training (SIT)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Meet diagnostic criteria for schizophrenia or schizoaffective disorder Are age 18-64 Fluent in written and spoken English Have an outpatient status of at least 1 month prior to participation Has been on a stable dose of psychiatric medication for at least one month prior to participation (titration to a lower dose of psychotropic medications under supervision of a psychiatrist can be allowed at the discretion of the investigators) Exclusion Criteria: Current or possibility of current pregnancy (self-reported) Active suicidal ideation at screening or baseline assessments, or previous intent to act on suicidal ideation with a specific plan, preparatory acts, or an actual suicide attempt within the last 3 months, as indicated by the C-SSRS WTAR standardized score below 70 American College of Sports Medicine contraindication to exercise

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 64 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sprint Interval Training (SIT)<br>The 1-session SIT protocol will include Work bouts performed at maximal intensity targets. Three Work bouts will be performed at 20-second intervals separated by 2 recovery bouts consisting of 2 minutes of low-intensity cycling. The SIT session will employ a standardized warm up and cool down of 3 minutes at a self-selected light intensity, per current guidelines. SIT sessions will take 15 minutes to complete. | Other: Sprint Interval Training (SIT)<br>* Active arm-- exercise dictated by protocol<br>|
| Stretching<br>Stretching will include a low-intensity range of motion and stretching exercises with session duration (15 minutes) being matched to SIT. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Individual Alpha Frequency | A prominent neural oscillatory rhythm measured from resting EEG. | through study completion, on average 2 weeks | 
| Change in Visual Attention | Computerized tasks that measure speeded sustained attention. | through study completion, on average 2 weeks | 
| Change in Visual Perception | Computerized tasks that measure speeded visual perception | through study completion, on average 2 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Psychosis, Schizophrenia, Schizoaffective Disorder, Exercise, Cognition, Attention