Effect of General Anesthesia Method on Cardiac Risk Patients on Ischemia Modified Markers

Study Overview
=================
Brief Summary
-----------------
To examine the effects of the general anesthesia method chosen in non-cardiac surgical operations of patients with cardiac risk on the levels of cardiac markers

Detailed Description
-----------------
To examine the effects of the general anesthesia method chosen in non-cardiac surgical operations of patients with cardiac risk on the levels of cardiac markers like; serum levels of the Creatine Kinase, Creatine Kinase Myocardial Band, high sensitive troponin, heart-type fatty acid-binding protein, ischemia-modified albumin and albumin. And evaluate the effect of anesthesia method on haemodynamic.

Official Title
-----------------
Effect of General Anesthesia Method Chosen in Non-cardiac Surgery of Cardiac Risk Patients on Ischemia Modified Albumin and Heart-Type Fatty Acid-Binding Protein (H-FABP) Levels

Conditions
-----------------
Anesthesia

Intervention / Treatment
-----------------
* Procedure: TIVA
* Procedure: GENERAL ANESTHESIA


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Being 18 years or older Getting a score of 2 and above according to the Lee cardiac index Having a non-cardiac surgical procedure that will take at least three hours ASA II or III Exclusion Criteria: Under 18 years old Those who refused to participate in the study Patients with chronic renal failure Patients with creatinine value ≥ 1.5 mg/dl Surgery that takes less than 3 hours Patients with liver failure Refusing to participate in the study Being allergic to the drugs used

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: GROUP TIVA<br>Anesthesia will be maintained with propofol (6-10 mg/kg/hour) and remifentanil (0.1-0.3 μg/kg/min). Blood will be taken from the patients at 0, 1 and 4 hours, centrifuged and stored at -80 degrees. From these examples, CK, CKMB, HIGH SENSITIVE TROPONIN, HFABP, IMA AND ALBUMIN will be studied. | Procedure: TIVA<br>* Anesthesia will be maintained with propofol (6-10 mg/kg/hour) and remifentanil (0.1-0.3 μg/kg/min).<br>|
| Active Comparator: GROUP INHALATION ANESTHESIA<br>Anesthesia will be maintained with sevoflurane (2 ml/min) 50% oxygen and remifentanil (0.1-0.3 μg/kg/min). Blood will be taken from the patients at 0, 1 and 4 hours, centrifuged and stored at -80 degrees. From these examples, CK, CKMB, HIGH SENSITIVE TROPONIN, HFABP, IMA AND ALBUMIN will be studied. | Procedure: GENERAL ANESTHESIA<br>* Anesthesia will be maintained with sevoflurane (2 ml/min) 50% oxygen and remifentanil (0.1-0.3 μg/kg/min).<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| comparing serum levels of ischemia modified albumin | serum levels of ischemia modified albumin (in terms of IU/ML) | intraoperative period | 
| comparing serum levels of heart fatty acid binding protein | serum levels of heart fatty acid binding protein (in terms of mcg/L) | intraoperative period | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The effect of anesthesia method used in cardiac risk patients in terms of ephedrine consumption | used ephedrine amount (mg) | intraoperative period |