The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active Adults

Study Overview
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Brief Summary
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The purpose of this study is to determine if an acute bout of removal of exercise reduces enothelial function and glycemic control in an active, older adult population; and whether a 3 day return to exercise restores this response. Glycemic control is the blood glucose response following the consumption of a meal. It is an indicator of insulin resistance (or type 2 diabetes) and impaired glycemic control has been suggested to lead to cardiovascular disease. Endothelial function has been shown to be improved by chronic or acute increases in physical activity. Both of these have been shown to be impaired to acute bouts of inactivity in young populations; however the impact of acute inactivity in older adults is less understood. In this proposal the investigators will examine 1)how quickly impairments in glycemic control occur to acute physical inactivity in older adults who exercise, 2) how quickly impairments in endothelial function occur to acute inactivity in older adults who exercise, and 3) whether 3 days of a return to exercise restores these responses.

Official Title
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The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active

Conditions
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Glucose Intolerance, Exercise, Vascular Function

Intervention / Treatment
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* Other: removal of exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 55 years and older, 18-40 years old Healthy, physically active, performing at least 90 min/week of physical activity Free of physical limitations that may interfere with alterations in daily physical activity levels Exclusion Criteria: Physician diagnosed HIV, hepatitis, or tuberculosis. Body weight change of greater than 5% within the previous 2 months Smoking within the previous 2 months. Taking medications that alter blood glucose levels
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Metabolic<br>Metabolic: Participants will have their blood glucose levels measured via continuous glucose monitoring for 3 days while participating in their normal exercise routines (EX). Participants will also have their blood glucose levels measured for 3 days while not exercising (NOEX), following immediately by 3 days of a return to normal activity(REX). Participants will be randomized to participate in the EX or NOEX/REX phases first. The EX and NOEX/REX phases will be separated by at least 1 week | Other: removal of exercise<br>* Subjects will stop doing their normal exercise routines for 3 or 5 days and then subjects will resume doing their normal exercise routines for 3 days.<br>* Other names: return to exercise;|
| Experimental: Vascular<br>Vascular: Participants will have their blood vessel health measured while performing their normal exercise routines (EX) and while undergoing 1, 3, 5 days of no exercise (NOEX) followed immediately by 1 and 3 days of return to exercise (REX). | Other: removal of exercise<br>* Subjects will stop doing their normal exercise routines for 3 or 5 days and then subjects will resume doing their normal exercise routines for 3 days.<br>* Other names: return to exercise;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Continuous glucose monitoring |  | 3 days before removal of exercise | 
| Continuous glucose monitoring |  | After removal of exercise for 5 days | 
| Continuous glucose monitoring |  | After return to exercise for 3 days | 
| Flow mediated dilation | This measure assess blood vessel health non-invasively | 3 days before removal of exercise | 
| Flow mediated dilation (vascular health) | This measure assess blood vessel health non-invasively | After removal of exercise for 5 days | 
| Flow mediated dilation (vascular health) | This measure assess blood vessel health non-invasively | After return to exercise for 3 days |