Distinction Between Lung Cancer and Gynecological Cancers by Canine Scent Detection

Study Overview
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Brief Summary
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Previous studies have shown that specially trained sniffer dogs are capable to discriminate breath samples of patients with lung cancer and healthy individuals. So far it is not known whether this differentiation is specific for lung cancer or just identifies any form of (solid) tumor. Therefore, the dog's ability to differentiate between lung cancer, breast cancer and ovarian cancer is tested.

Official Title
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Distinction Between Lung Cancer and Gynecological Cancers by Exhalation Analysis and Canine Scent Detection

Conditions
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Breast Cancer, Lung Cancer, Ovarian Cancer

Intervention / Treatment
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* Other: exhalation analysis of breath sample


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: histologically confirmed lung or breast or ovarian cancer Exclusion Criteria: other cancers previous medical intervention within the last 14 days before gathering of the breath sample

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sham Comparator: healthy individual<br>healthy individual with no lung disease and no history of cancer including lung cancer | Other: exhalation analysis of breath sample<br>* study participants exhale 5 times into a test tube; test tube is presented to sniffer dogs for analysis<br>|
| Experimental: lung cancer<br>patients with histologically confirmed lung cancer, but no history of other cancer | Other: exhalation analysis of breath sample<br>* study participants exhale 5 times into a test tube; test tube is presented to sniffer dogs for analysis<br>|
| Experimental: breast cancer<br>patients with histologically confirmed breast cancer, but no history of other cancer | Other: exhalation analysis of breath sample<br>* study participants exhale 5 times into a test tube; test tube is presented to sniffer dogs for analysis<br>|
| Experimental: ovarian cancer<br>patients with histologically confirmed ovarian cancer, but no history of other cancer | Other: exhalation analysis of breath sample<br>* study participants exhale 5 times into a test tube; test tube is presented to sniffer dogs for analysis<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Specificity for Lung Cancer | exhalation analysis by sniffer dogs is able to differentiate breath samples of patients with lung cancer from those of patients with other (tested) cancers | breath samples will be tested within 40 days after gathering | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Discriminability of breast and ovarian cancer | exhalation analysis by sniffer dogs is able to differentiate breath samples of patients with breast cancer from those of patients with other ovarian cancer | breath samples will be tested within 40 days after gathering | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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volatile organic compounds, screening, lung cancer, breast cancer, ovarian cancer, canine scent detection, breath sample analysis, exhalation analysis