Exercise Intensity and Appetite in Adolescents

Study Overview
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Brief Summary
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Acute exercise has been shown to affect subsequent energy intake in obese adolescents. Indeed, it has been shown several times that an intensive bout of exercise (above 70% of the individual maximal capacities) can reduce energy intake at the following meal in obese adolescents, with no modification of his appetite feelings. Although this results has been replicated several times, it remains unknown if those nutritional adaptations are due to post-exercise modifications of some gastro-peptides implicated in appetite control, as detailed in adults. The aim of this work is to question whether or not post-exercise energy intake is explained by appetite-regulating hormones that are affected by the exercise bout in both lean and obese youth.

Detailed Description
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After an first medical visit to ensure that the adolescents have the ability to complete the whole study, the participants will have to complete several clinical examinations: anthropometric measurements Body composition assessed by dual energy x-ray absorptiometry Maximal aerobic test They will then randomly complete the following conditions: CON: a control day without exercise; HIE: an exercise day with an exercise set at 75% of the capacities LIE: an exercise day with an exercise set at 40% of the capacities The exercises or the rest condition will be done by the end of the morning and a buffet meal will be proposed during which the participants will be asked to eat as much as wanted. Blood samples will be drawn before, after, 15 after and 30 minutes after the exercise to assess the main appetite regulating hormones involved in appetite regulation (PYY, Cholecystokinin ...) appetite feelings will be assessed throughout the day at regular interval using visual analogue scales.

Official Title
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Effect of Acute Exercise Intensity on Energy Intake in Adolescents: Effect of Weight Status

Conditions
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Pediatric Obesity

Intervention / Treatment
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* Behavioral: acute exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 12 to 15 years old adolescents Obese according to international values for BMI Being registered to the national social security insurance no eating disorders no medications metabolic disorders Exclusion Criteria: metabolic disorders food disorders physical disability

Ages Eligible for Study
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Minimum Age: 12 Years
Maximum Age: 15 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Lean adolescents<br>15 lean adolescents (BMI Under the national cut-offs for obesity), 12-15 years old, males, will be recruited | Behavioral: acute exercise<br> <br> |
| Experimental: Obese adolescents<br>15 obese adolescents (BMI above the national cut-offs for obesity), 12-15 years old, males, will be recruited | Behavioral: acute exercise<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| energy intake in kcal | buffet meal | up to 2 months |