Comparison of Repeatability Between SS and SD-OCT for Measuring Retinal Thickness in Various Retinal Diseases

Study Overview
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Brief Summary
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Comparison of intradevice repeatability of thickness measurements for macular area in the eyes with normal and various retinal diseases using SS-OCT and SD-OCT

Detailed Description
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The investigators studied the intradevice repeatability of thickness measurements for total retina, retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform (GC-IPL) layers of macular area in the eyes with normal and various retinal diseases using SS-OCT and SD-OCT and compared the repeatability between two devices.

Official Title
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Comparison of Repeatability Between Swept-source and Spectral-domain Optical Coherence Tomography for Measuring Inner Retinal Thickness in Various Retinal Diseases

Conditions
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Macula Abnormality

Intervention / Treatment
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* Device: Repeat exams of OCT device


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age-matched normal group was composed of subjects with age over at least 19 years, a best-corrected visual acuity of 20/25 or higher, normal fundus and intraocular pressure (IOP) < 21mm Hg. Exclusion Criteria: an spherical equivalent (SE) larger than ± 6 D, cataract graded as more severe than grade 3 (Lens Opacities Classification System III), a history of glaucoma and optic nerve diseases, or a history of vitrectomy.

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Normal group<br>Healthy subjects without any ocular problems Repeat exams of OCT device (SD and SS-OCT) | Device: Repeat exams of OCT device<br>* All 2 consecutive OCT examinations were performed by 1 experienced technician, in the order of SD-OCT and SS-OCT. The interval was 10 minutes between examinations by each OCT devices<br>|
| Retinal diseases group<br>Patients with various macular diseases Repeat exams of OCT device (SD and SS-OCT) | Device: Repeat exams of OCT device<br>* All 2 consecutive OCT examinations were performed by 1 experienced technician, in the order of SD-OCT and SS-OCT. The interval was 10 minutes between examinations by each OCT devices<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To compare repeatability between swept-source optical coherence tomography (SS-OCT) and spectral-domain OCT (SD-OCT) devices for the measurement of retinal thickness in various retinal diseases. | Comparison of Intraclass correlation coefficient (ICC) and coefficients of variability (CV) between devices | Each device was examined twice consecutively within one minutes. After one OCT device exam, another OCT exam was performed immediately. The interval between test devices did not exceed 5 minutes. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To compare repeatability according to the degree of macular thickness | To compare the repeatability of retinal thickness according to central macular thickness in eyes with retinal diseases | Each device was examined twice consecutively within one minutes. After one OCT device exam, another OCT exam was performed immediately. The interval between test devices did not exceed 5 minutes. |