The Correlation Between Filling Pressure, Cardiac Output and Plasma Copeptin in Patients With Systolic Heart Failure

Study Overview
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Brief Summary
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The relationship between the activation of the vasopressin system and central hemodynamics in heart failure (including right and left heart filling pressures and cardiac output) is not clear. The investigators intend to examine the correlation between levels of copeptin and vasopressin and the central hemodynamic system in patients with advanced (class III or IV) heart failure. The investigators also aim to examine the relationship of selected cardiac biomarkers in blood and urine with cardiac filling pressures and cardiac output in patients with decompensated heart failure. The study population will consist of 30 patients admitted to the Department of Cardiology at Copenhagen University Hospital. Only patients for whom the attending cardiologist has already decided upon right heart catheterization for clinical/treatment reasons will be recruited for the study.

Official Title
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The Correlation Between Filling Pressure, Cardiac Output and Plasma Copeptin in Patients With Systolic Heart Failure

Conditions
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Heart Failure

Intervention / Treatment
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* Other: Standard of care therapy for severe decompensated heart failure


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age > 18 years Left ventricular ejection fraction < 40 % Diagnosed symptomatic heart failure treated with heart failure medications for at least 30 days. Clinical indication for right heart catheterization for clinical/treatment reasons NYHA-class III-IV Relevant heart failure treatment as tolerated by the patient Exclusion Criteria: Absence of clinical/treatment indication of right heart catheterization Syndrome of Inappropriate Secretion of ADH (SIADH) Recent acute myocardial infarction within the last 30 days Presence of infection or inflammatory disease Malignant disease Pregnancy Subjects unwilling or unable to provide written consent

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Blood and urine samples<br> | Other: Standard of care therapy for severe decompensated heart failure<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The correlation between levels of plasma copeptin and vasopressin with left ventricular filling pressure and cardiac output |  | Day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The correlation between levels of plasma copeptin and vasopressin with urine aquaporin-2 concentration |  | Day 1 | 
| The correlation between New York Heart Association (NYHA) class and levels of plasma copeptin and vasopressin |  | Day 1 | 
| The correlation between biomarkers levels and survival free of transplantation- and left ventricular assist device insertion |  | 1 year |