Skin Barrier Biophysical Properties and Clinical Appearance After Moisturizer in Dry Skin

Study Overview
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Brief Summary
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The purpose of the study is to compare the changes in the appearance of dry skin after the use various moisturizers: white petrolatum ointment, coconut oil, jojoba oil, and almond oil in patients with dry skin.

Detailed Description
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The goal of this study is to compare how the appearance of dry skin changes before and after the use of following moisturizers: white petrolatum, coconut oil, jojoba oil and almond oil). Up to 40 subjects from Banner-University Medical Center/University of Arizona dermatology clinics and University of California, Davis dermatology clinics (up to 20 subjects per site) who have dry skin will be enrolled in this study and randomized to receive the four moisturizers on four locations on their forearms.There will be a total of 3 study sessions: baseline, and approximately 1 and 2 weeks for follow up assessment. At each visit, dry skin severity will be evaluated by a trained observer using a validated Dry Skin Score, skin barrier biophysical properties (transepidermal water loss and hydration) will be measured, and digital photos of the test sites will be taken for image analysis.

Official Title
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Evaluating Skin Barrier Biophysical Properties and Clinical Appearance After Moisturizer Use in Patients With Dry Skin

Conditions
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Xerosis, Xerosis Cutis, Dry Skin; Eczema

Intervention / Treatment
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* Other: virgin coconut oil
* Other: virgin jojoba oil
* Other: virgin almond oil
* Other: white petrolatum ointment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male and female, at least 18 years of age Subject must receive a diagnosis of dry skin by a dermatologist. Subject must be able to comprehend and read the English language. Exclusion Criteria: Subjects who do not fit the inclusion criteria. Subjects unable to or unwilling to comply with the study procedures Prior known allergy to white petrolatum, coconut oil, almond oil, or jojoba oil. People who have used products containing white petrolatum, jojoba oil, coconut oil, or almond oil within the past week. People with a known diagnosis of ichthyosis. A subject who, in the opinion of the investigator, will be un-cooperative or unable to comply with study procedures. Subject unable to speak or read the English language, since all consents and instructions will be provided in English. Those that are prisoners or cognitively impaired

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: virgin coconut oil<br>All subjects will apply virgin coconut oil to a previously randomize section of the skin on the left or right forearm. | Other: virgin coconut oil<br>* One of the four locations (right proximal forearm, right distal forearm, left proximal forearm, left distal forearm) on the forearm will be selected to receive virgin coconut oil application twice daily for 2 weeks.<br>|
| Active Comparator: virgin jojoba oil<br>All subjects will apply virgin jojoba oil to a previously randomize section of the skin on the left or right forearm | Other: virgin jojoba oil<br>* One of the four locations (right proximal forearm, right distal forearm, left proximal forearm, left distal forearm) on the forearm will be selected to receive virgin jojoba oil application twice daily for 2 weeks.<br>|
| Active Comparator: virgin almond oil<br>All subjects will apply virgin almond oil to a previously randomize section of the skin on the left or right forearm | Other: virgin almond oil<br>* One of the four locations (right proximal forearm, right distal forearm, left proximal forearm, left distal forearm) on the forearm will be selected to receive virgin almond oil application twice daily for 2 weeks.<br>|
| Active Comparator: white petrolatum ointment<br>All subjects will apply white petrolatum ointment to a previously randomize section of the skin on the left or right forearm. | Other: white petrolatum ointment<br>* One of the four locations (right proximal forearm, right distal forearm, left proximal forearm, left distal forearm) on the forearm will be selected to receive white petrolatum ointment application twice daily for 2 weeks.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The appearance of xerosis | The clinical severity of xerosis of the 4 location will be graded by a trained observed using a previously validated Dry Skin Scale and by analysis of the digital photos. | 14 days |