Assessment of Reconstruction and Inverse Reconstruction in Right Atrium by Multimodal Echocardiographic Techniques

Study Overview
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Brief Summary
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The purpose of the study is to assess the reconstruction and inverse reconstruction in right atrium by speckle tracking echocardiography combined with real-time three dimensional echocardiography for atrial fibrillation patients before and after radiofrequency ablation (RFCA)

Detailed Description
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The prevalence of atrial fibrillation (AF) has increased in recent years. The construction and function of right atrium haven't shown clearly before and after radiofrequency ablation (RFCA).The purpose of the study is to investigate whether RFCA can lead to inverse reconstruction of right atrium for atrial fibrillation patients, which diagnosing by speckle tracking echocardiography combined with real-time three dimensional echocardiography. All patients will be followed up for 12 months.

Official Title
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Assessment of Reconstruction and Inverse Reconstruction in Right Atrium by by Multimodal Echocardiographic Techniques for Atrial Fibrillation Patients Before and After Radiofrequency Ablation

Conditions
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Paroxysmal Atrial Fibrillation

Intervention / Treatment
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* Procedure: radiofrequency ablation (RFCA)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: With a history of paroxysmal Af (PAF) and PAF record within 6 months prior to ablation, confirming at least one of the following findings: AF lasting for ≥30 s recorded in Holter or 12-lead ECG. No response to more than one antiarrhythmic drug, or unwilling to receive longterm drug treatment. Can provide informed consent form expressing willingness to participate in the study and comply with follow-up tests and evaluation procedures. Aged 18-80 years. Exclusion Criteria: With acute diseases, such as acute phase after myocardial infarction (within 3 months), within 3 months after acute heart failure or new cerebral infarction; In the list of heart transplantation; Expected survival less than 1 year; With other hemorrhagic diseases and anticoagulant therapy is not allowed; Thrombosis in left atrium; Heart failure, New York Heart Association(NYHA) III/IV or eject fraction(EF)<40%; Patients with uncontrolled cancer; Significant hepatic or renal impairment (and/or alanine transaminase(ALT) or Aspartate transaminase(AST) >2 times upper limit of normal, creatinine clearance rate(CCr)<50%); Previous catheter radiofrequency ablation for AF or cardiac surgery; Pregnant and lactating women, women who plan to become pregnant, or women of child bearing age not using reliable contraceptive measures.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: patients with AF<br>Before radiofrequency ablation (RFCA) | Procedure: radiofrequency ablation (RFCA)<br>* Patients undergo radiofrequency ablation (RFCA)<br>|
| Experimental: Assigned Comparisons<br>After radiofrequency ablation (RFCA) | Procedure: radiofrequency ablation (RFCA)<br>* Patients undergo radiofrequency ablation (RFCA)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Remodeling in right atrium measured by speckle tracking echocardiography combined with real-time three dimensional echocardiography in AF patients |  | In one week before RFCA | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Remodeling in right atrium measured by speckle tracking echocardiography combined with real-time three dimensional echocardiography in AF patients |  | In one week after RFCA | 
| Inverse reconstruction in right atrium measured by speckle tracking echocardiography combined with real-time three dimensional echocardiography in AF patients |  | At three months after RFCA | 
| Inverse reconstruction in right atrium measured by speckle tracking echocardiography combined with real-time three dimensional echocardiography in AF patients |  | At six months after RFCA | 
| Adverse event that is related to RFCA, such as the incidence of cardiac tamponade (%) was obtained by echocardiography |  | In one week after RFCA | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Right atrium, Echocardiography, Remodeling