Exploring the Effects of Diazepam and Lorazepam

Study Overview
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Brief Summary
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Aims : exploring lorazepam (0.038 mg/kg) effects, after a single oral intake, in healthy volunteers, on the neural correlates of encoding and retrieval of information during a word-stem completion task (implicit memory), using fMRI comparing lorazepam effects to diazepam (0.3 mg/kg)effects exploring benzodiazepines effects, after a single oral intake, on the neural correlates of successful encoding of information within explicit memory using fMRI Hypothesis : both diazepam and lorazepam will impair explicit memory performance, but lorazepam only will impair perceptual priming lorazepam and diazepam will modify the normal correlates of information encoding within explicit memory lorazepam only will alter the neural correlates of perceptual priming

Official Title
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Exploring the Effects of Diazepam and Lorazepam on the Neural Correlates of Perceptual Priming and Explicit Memory in Healthy Volunteers

Conditions
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Healthy Subjects

Intervention / Treatment
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* Drug: Diazepam
* Drug: Lorazepam
* Drug: placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy subjects between 18 and 30 years Students in medicine, dentistry or pharmacy French as a mother language Exclusion criteria: Medical condition influencing brain function (neurological or psychiatric) Asthma General anesthesia in the 3 last months Drug addiction (DSM IV criteria) Regular medical treatment (except contraceptive pill) Significant impairment observed during a medical examination including ECG Intake of any psychotropic drug that can have a effect during testing IQ (Wechsler) < 100 FMRI contra-indication (implantable magnetic material, claustrophobia) Known allergy to benzodiazepine or lactose > 10 cigarettes/day Pregnant or breast-feeding woman No health insurance Subjects who do not complete the entire study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Oral Lorazepam | Drug: Lorazepam<br>* Lorazépam drug (0,038 mg/kg) on a single oral intake<br>|
| Experimental: 2<br>Oral Diazepam | Drug: Diazepam<br>* Diazépam drug (0,3 mg/kg) on a single oral intake<br>|
| Placebo Comparator: 3<br>Oral placebo | Drug: placebo<br>* lorazépam placebo or Diazépam placebo<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Exploring lorazepam (0.038 mg/kg) effects, after a single oral intake, in healthy volunteers, on the neural correlates of encoding and retrieval of information during a word-stem completion task (implicit memory), using fMRI |  | After a single oral intake | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparing lorazepam effects to diazepam (0.3 mg/kg)effects |  | After a single oral intake | 
| Exploring benzodiazepines effects, after a single oral intake, on the neural correlates of successful encoding of information within explicit memory using fMRI |  | After single oral intake | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Benzodiazepines, Lorazepam, Diazepam, Memory, Perceptual priming, Functional brain imaging, FMRI