Effect of Beta Blocker Treatment on Endothelial Function in Patients With Type 2 Diabetes or Chronic Heart Failure

Study Overview
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Brief Summary
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The aim of this study is to evaluate the effect of the two different beta blockers metoprolol and carvedilol on endothelial function in patients with either type two diabetes or chronic heart failure. Hypothesis: 1* Carvedilol compared to metoprolol has a favourable effect on endothelial function. 2* Carvedilol compared to metoprolol has a favourable effect on insulin stimulated endothelial function. The study is conducted as an open parallel group study. Endothelial function and insulin stimulated endothelial function was evaluated before and after a two months treatment period with either of the two beta blockers.

Detailed Description
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Endothelial function is deteriorated in patients with type 2 diabetes and in patients with chronic heart failure. Treatment with carvedilol improves survival in patients with chronic heart failure compared to treatment with metoprolol. Carvedilol improves metabolic glucose control in patients with diabetes compared to metoprolol.Carvedilol compared to metoprolol also decreases the number of patients with new onset diabetes among patients with chronic heart failure. The mechanism behind these findings has not been fully understood. The purpose of this study is to investigate if carvedilol compared to metoprolol has a favourable effect on endothelial function and insulin stimulated endothelial function, in groups of patients with either diabetes or chronic heart failure.

Conditions
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Endothelial Function, Beta Blocker

Intervention / Treatment
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* Drug: Treatment with either metoprolol or carvedilol


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Type 2 diabetes Chronic heart failure Exclusion Criteria: For patients with type 2 diabetes: * Vascular complications. For patients with chronic heart failure: Severe uncontrolled heart failure. Untreated severe hypertension, hypotension. Bradycardia. Known intolerance to beta blocker treatment. Pregnancy,

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Treatment with either metoprolol or carvedilol|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Endothelial function and insulin stimulated endothelial function |  | 2 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Insulin stimulated glucose uptake |  | 2 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Endothelial function, Beta blocker, Type 2 diabetes, Chronic heart failure