Reproductive Outcome in Assisted Conception Cycles

Study Overview
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Brief Summary
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Infertility is the failure to conceive after regular unprotected sexual intercourse for one year. Primary infertility refers woman who has never conceived, and secondary infertility to one who has had a previous pregnancy.The most frequent causes for infertility are ovulatory disorder or anovulation (27-30%) , tubal factor(20-22%), abnormal semen parameters(45-50%). Unexplained infertility refers to infertile couples in whom standard investigations, including tests of ovulation, tubal patency tests and semen analysis are normal. incidence 15-17% of infertile couples. New guidelines on infertility recommend that women with unexplained infertility should be advised for expectant management for 2 years .If pregnancy is not achieved after this period In vitro fertilization Should be considered. The Fast Track and Standard Treatment trial demonstrated A shorter time to pregnancy and higher per cycle pregnancy rates for In vitro fertilization compared with treatment with oral agents or gonadotropins in Patients with unexplained infertility. Successful pregnancy after assisted reproductive technology is influenced by numerous predictors that have been investigated in the previous years. The central predictors of success are the sperm, oocyte quality and endometrial receptivity. Oocyte quality depends mainly on the age of the woman , and her ovarian reserve. Parameters most commonly studied are the woman's age , her antral follicle count , and laboratory tests including serum randomly done during the menstrual cycle levels at day 3 of the cycle.

Official Title
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Prediction Of Reproductive Outcome in Assisted Conception Cycles in Women With Unexplained Infertility

Conditions
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Infertility

Intervention / Treatment
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* Diagnostic Test: follicular stimulating hormone
* Diagnostic Test: Anti-mullerian hormone
* Radiation: Basal antral follicle count


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: in vitro fertilization treatment due to many factors including tubal, male, and unexplained factors. body mass index (BMI) (18-35)kg/m2 Exclusion Criteria patient age less than 20 and more than 40 years. body mass index less than 18 and more than 35 kg/m2. period of infertility less than 2 years.. untreated hyperthyroidism, hypothyroidism, diabetes, hypertension.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Patients with unexplained infertility<br> | Diagnostic Test: follicular stimulating hormone<br>* in the serum of our patients<br>Diagnostic Test: Anti-mullerian hormone<br>* in the serum of our patients<br>Radiation: Basal antral follicle count<br>* by ultrasound<br>|
| Other: patients with tubal, male factor or polycystic ovary syndrome<br> | Diagnostic Test: follicular stimulating hormone<br>* in the serum of our patients<br>Diagnostic Test: Anti-mullerian hormone<br>* in the serum of our patients<br>Radiation: Basal antral follicle count<br>* by ultrasound<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| live birth rate |  | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of fertilized oocytes |  | 3 days |