Determination of Risk Factors for the Development of Obesity and Hypertension in Children According to Perinatal Programming of Metabolism

Study Overview
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Brief Summary
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to determine the risk factors for developing obesity in children with exogenous-constitutional obesity and arterial hypertension, according to the theories of early programming of metabolism

Detailed Description
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A retrospective cohort study of 55 children aged 12 to 18 years (average 14.60±0.24 years) with exogenous-constitutional obesity was conducted, with 24 girls (43.6%) and 31 (56.4%) boys. Children were identified during dispensary examinations in family clinics in Samarkand in the period 2018-2019. All the examined children belonged to the Uzbek population.

Official Title
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Determination of Risk Factors for the Development of Obesity and Hypertension in Children According to Perinatal Programming of Metabolism

Conditions
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Metabolic Syndrome

Intervention / Treatment
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* Other: Risk Factors


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: SDS (standart deviation score) of body mass index (BMI) ranging from +2.0 to +3.0 Exclusion Criteria: secondary obesity and overweight genetic syndromes, refusal of the child and/or parents to be examined

Ages Eligible for Study
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Minimum Age: 12 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1 group<br>Group I consisted of 17 people (16.83%) with a uniform type of obesity | Other: Risk Factors<br>* BMI in children and adolescents was compared with percentile charts developed by who for children from 5 to 19 years of age (WHO Growth Reference, 2007). Body mass index was defined as the ratio of body weight (in kg) to body length in the supine position or height in the standing position (m2).<br>|
| 2 group<br>Group II included 38 children with AO, and 20 of them had normal BLOOD pressure | Other: Risk Factors<br>* BMI in children and adolescents was compared with percentile charts developed by who for children from 5 to 19 years of age (WHO Growth Reference, 2007). Body mass index was defined as the ratio of body weight (in kg) to body length in the supine position or height in the standing position (m2).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Risk factors of metabolic syndrome | A retrospective, cohort study of 55 children aged 12 to 18 years with exogenous constitutional obesity will be conducted Children with exogenous-constitutional obesity were divided by the presence of abdominal (visceral) obesity and the presence of hypertension. Parents will be interviewed and medical records (forms 003/y and 112) of children with exogenous constitutional obesity will be analyzed. Also, on the basis of a specially developed questionnaire, children with exogenous constitutional obesity were surveyed. When conducting a survey of children and their parents, the following factors will be of particular importance: heredity, pregnancy, weight and body length at birth, the nature of nutrition in the first two years of life, eating habits, and physical activity. | up to 36 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Metabolic Syndrome, children, obesity