Adductor Canal Block Versus Patient Controlled Analgesia, in the Surgical Stress Response for Anterior Cruciate Ligament Repair

Study Overview
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Brief Summary
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To evaluate the surgical stress response in anterior cruciate ligament repair with an adductor canal block versus patient controlled endovenous analgesia.

Detailed Description
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Preoperative, 2 hours and 24 hours stress biomarkers will be evaluated in two groups of patients, continous adductor canal block and morphine patient controlled endovenous analgesia.

Official Title
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Impact of Adductor Canal Block, Compared to Patient Controlled Analgesia, in the Surgical Stress Response of Patients Programmed for Traumatic Anterior Cruciate Ligament Repair

Conditions
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Anesthesia, Stress, Physiological, Surgery

Intervention / Treatment
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* Procedure: Adductor Canal Block
* Device: Morphine Patient Controlled Analgesia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male, 18-65 years, traumatic Anterior Cruciate Ligament tear, scheduled for elective arthroscopic repair with Semitendinous-Gracillis technique at first time in the morning, with full articular range, no other traumatologic lesions. Exclusion Criteria: denied consent to participate, chronic steroids user, diabetes type 1 or 2, insulin resistance, concurrent infectious disease, cognitive failure, coagulopathy, allergy to study drugs, surgery scheduled in the afternoon

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Adductor Canal Block<br>With mild sedation, a continous bupivacaine 0.1% infusion catheter is placed in the adductor canal. Afterwards, patients are placed under General Anesthesia, and surgery starts. Preoperative, 2 hours and 24 hours stress biomarkers and analgesic quality will be measured. | Procedure: Adductor Canal Block<br>* Continous peripheral nerve block<br>|
| Active Comparator: Patient Controlled Morphine Analgesia<br>Patients are placed under General Anesthesia, and after surgery, a Morphine patient controlled analgesia delivery system is installed. Preoperative, 2 hours and 24 hours stress biomarkers and analgesic quality will be measured. | Device: Morphine Patient Controlled Analgesia<br>* Morphine Patient Controlled Analgesia Delivery System<br>* Other names: Patient Controlled Analgesia;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of Blood Cortisol from baseline to 24 hours | Blood Cortisol will be evaluated preoperatively, 2 hours and 24 hours postoperatively. | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of C Reactive Protein from baseline to 24 hours | C Reactive Protein will be evaluated preoperatively, 2 hours and 24 hours postoperatively. | 24 hours | 
| Change of Glycemia from baseline to 24 hours | Glycemia will be evaluated preoperatively, 2 hours and 24 hours postoperatively. | 24 hours |