Childhood Measures of NICU-based Chemical Exposure

Study Overview
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Brief Summary
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This study aims to identify early life exposures to metals and chemicals by measuring the concentration of metals and organic compounds in shed primary teeth. The researchers will also investigate associations between the presence of these chemicals in teeth and children's social, emotional, and neuro-development.

Detailed Description
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Since children begin shedding their primary teeth around age 6, the investigators will enroll children who will be turning 6 in the next two years. First, the investigators will follow up with the children's development by conducting a battery of non-invasive neurodevelopmental tests. Also, the parents will be asked to complete a questionnaire called the Child Behavior Checklist, which assesses behavioral problems. Then, each child's parent will be asked to send the research team 2-3 teeth that their child has shed, or to send teeth as they are shed over the next three years. Dr. Stroustrup's collaborator, Dr. Manish Arora, will perform a temporal analysis of chemical distribution for each tooth to determine each child's environmental exposures during the perinatal and neonatal periods.

Official Title
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Novel Biomarkers for Exposures in the Neonatal Intensive Care Unit

Conditions
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Development

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 4-6 years of age in 2014 (six years of age by the end of 2016) Cared for as a neonate in Mount Sinai's NICU Exclusion Criteria: Parent documented in Mount Sinai's database is no longer the legal guardian Non-English-speaking parents

Ages Eligible for Study
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Minimum Age: 4 Years
Maximum Age: 6 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| NICU Tooth Study Cohort<br>All study subjects will have been cared for in the Mount Sinai NICU and have had the same hospital environment exposure. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Chemical Concentration in deciduous teeth | Teeth will be analyzed by a dentist and researcher trained in laser ablation inductively coupled plasma mass spectroscopy technology | up to 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Child Behavior Checklist | An assessment Developmental Outcomes measured using this assessments | up to 3 years | 
| Wechsler Preschool and Primary Scale of Intelligence | Developmental Outcomes measured using this assessments | up to 3 years | 
| Development Neuropsychological Assessment (NEPSY) | Developmental Outcomes measured using this assessments | up to 3 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dentin, environmental exposures, neurodevelopmental outcomes