Doppler Ultrasound Assisted Varicocelectomy Improve Sperm Qualities

Study Overview
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Brief Summary
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To evaluate the benefits of laparoscopic Doppler ultrasound (LDU) assisted laparoscopic varicocelectomy (LV) and compare the surgical outcomes and complications between LDU assisted LV (LDU-LV) and microscopic subinguinal varicocelectomy for infertile patients with varicoceles.

Detailed Description
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To compare the surgical outcomes such as semen parameters and the pregnancy rate and complications like postoperative varicocele recurrence and hydrocele between laparoscopic Doppler ultrasound assisted laparoscopic varicocelectomy and conventional microscopic subinguinal for infertile patients with varicoceles. To examine the microanatomy of the spermatic cord within suprainguinal portion.

Official Title
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Comparison Between Laparoscopic Doppler Ultrasound Assisted Laparoscopic Varicocelectomy and Microscopic Subinguinal Varicocelectomy

Conditions
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Varicocele

Intervention / Treatment
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* Procedure: Laparoscopic varicocelectomy
* Procedure: Microscopic Subinguinal varicocelectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 20-39 years old who had infertility for more than 1 year and had clinical palpable varicoceles; impaired semen quality including sperm concentration <15 million/ml or total motility <40% or progressively motile < 32% (a+b), the 5th edited World Health Organization criteria was referred; with normal level of serum hormones including follicle stimulating hormone, luteinizing hormone, Thyroid hormones and prolactin; patient's spouse was healthy in reproduction. Exclusion Criteria: with subclinical varicocele, recurrent varicoceles; normal semen analyses; other reasons of infertility than varicoceles; refusing to enter randomization; female partner older than 35 years; with abnormal level of serum hormones; female factor infertility; with significant surgical diseases, congenital diseases or endocrine diseases.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 39 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: laparoscopic varicocelectomy<br>laparoscopic Doppler ultrasound assisted laparoscopic varicocelectomy group | Procedure: Laparoscopic varicocelectomy<br>* Traditional laparoscopic varicocelectomy assisted by laparoscopic Doppler ultrasound<br>* Other names: Laparoscopic varicocelectomy assisted by Doppler ultrasound;|
| Sham Comparator: microscopic varicocelectomy<br>conventional Microscopic Subinguinal varicocelectomy group | Procedure: Microscopic Subinguinal varicocelectomy<br>* Infertile patients with clinically palpable varicoceles were selected to receive microscopic Subinguinal varicocelectomy<br>* Other names: Traditional microscopic Subinguinal varicocelectomy;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pregnancy rate |  | The pregnancy rate was calculated at 1 year of follow-up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| semen quality assessment | Routine sperm quality check including Count，Morphology and Motility using both the conventional manual method and computer assisted sperm analysis (CASA) systems. | semen quality assessment were checked at 3, 6 and 12 months after surgery. | 
| postoperative complications |  | postoperative complications at 3, 6 and 12 months after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Doppler Ultrasound, Laparoscopic, Microscopic Subinguinal Varicocelectomy