Effects of Phytonutrients Upon Muscle Perfusion in Response to Feeding

Study Overview
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Brief Summary
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This is a random order cross over design trial to evaluate the efficacy of select nutritional ingredients on enhancing muscle perfusion in response to an acute meal stimulus.

Official Title
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A Pilot Study to Explore the Acute Effects of Phytonutrients Upon Muscle Microvascular Blood Flow (Perfusion) in Response to Feeding in Older Adults.

Conditions
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Biological Aging

Intervention / Treatment
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* Other: Catechin Cohort 1
* Other: Curcuminoid Cohort 2
* Other: Flavonoid Cohort 3


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Body mass index (BMI) 18-30 kg/m2 Free from active metabolic disease Normotensive Exclusion Criteria: Habitual gym use or formal exercise (more than once a week) or other routine strenuous physical activity Smokers Surgery within past 3 months Active cardiovascular disease Taking beta-adrenergic blocking agents Cerebrovascular disease: Active respiratory disease Active metabolic disease Active inflammatory bowel or renal disease Active Malignancy or until confirmed remission Clotting dysfunction History of DVT Significant musculoskeletal or neurological disorders Family history of early (<55y) death from cardiovascular disease Known sensitivity to Sonovue contrast agent Known allergy or intolerance to any of the study ingredients Current use of any of the study ingredients

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: 3 cohorts, crossover within cohort
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Catechin Cohort 1<br>2 treatment - Experimental Catechin Blend; Control 1 Placebo | Other: Catechin Cohort 1<br>* - 4 capsules taken with water 1 hour prior to meal<br>|
| Experimental: Curcuminoid Cohort 2<br>2 treatment - Experimental Curcuminoid Blend; Control 1 Placebo | Other: Curcuminoid Cohort 2<br>* - 2 capsules taken with water 1 hour prior to meal<br>|
| Experimental: Flavonoid Cohort 3<br>2 treatment - Experimental Flavonoid Blend; Control 2 Low-Flavonoid Blend | Other: Flavonoid Cohort 3<br>* -   1 oz. serving consumed 30 minutes before meal<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| muscle microvascular blood flow | contrast enhanced ultrasound | Baseline to 240 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| muscle macrovascular blood flow | doppler ultrasound | Baseline to 240 minutes | 
| central vascular blood flow | echocardiography | Baseline to 90 minutes | 
| cerebral blood flow | doppler ultrasound | Baseline to 120 minutes | 
| endothelial function | flow mediated dilation | Baseline to 120 minutes |