Soft Tissue Profile Following Socket Preservation With Platelet Rich Fibrin Versus Free Gingival Graft

Study Overview
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Brief Summary
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Comparing socket preservation with Platelet -Rich Fibrin versus Free gingival graft.

Detailed Description
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Extraction of the non restorable tooth, then socket preservation is applied in experimental group using platelet rich fibrin, while in comparative group free gingival graft is applied with socket preservation.

Official Title
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Evaluation of the Soft Tissue Profile Following Socket Preservation With Platelet Rich Fibrin Versus Free Gingival Graft: A Randomized Controlled Study

Conditions
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Soft Tissue Mass

Intervention / Treatment
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* Other: platelet rich fibrin
* Other: Free gingival graft


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age range 25-50 years. Non- restorable teeth indicated for extraction. Good oral hygiene. Intact facial and lingual plates of bone, without infection or pathosis. Adequate apiacl bone for primaru stability Exclusion Criteria: Presence of uncontrolled Systemic disease eg: diabetes, bone disease or the use of medicines that interfere with bone metabolism, history of head and neck radiotherapy. Presence of periodontal and/or periapical infection. Smokers. Non-compliant patients. Pregnancy or lactation in females. History of head and neck radiotherapy.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: PRF (Platelet -rich fibrin) group<br>Extraction of the tooth followed by Platelet rich fibrin placed in the socket covered bu platelet rich fibrin membrane for socket preservation. | Other: platelet rich fibrin<br>* platelet rich fibrin will be prepared from patient's venous blood and inserted in the centrifuge at 2000 r.p.m. for 12 minutes Then, the Platelet rich fibrin plug will be placed in the socket after extraction for socket preservation covered by platelet rich fibrin membrane.<br>|
| Active Comparator: Free gingival graft group<br>Extraction of the tooth followed by using free gingival graft to cover the socket for socket preservation. | Other: Free gingival graft<br>* Free gingival graft will be taken from the palate to cover the socket after extraction of the tooth for socket preservation.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Soft tissue profile change | Optical scanning by optical scanner at baseline to the preoperative cast of the related area, then optical scanning to postoperative cast of the surgical area after 6 months. Then, superimposition between the two scans of the casts will be performed to measure the difference or change in the amount of soft tissue profile measured in millimeters between baseline and at 6 months | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Crestal bone level change | measured by Cone beam computed tomography (CBCT) taking the neighboring teeth as reference points, with superimposition between readings at baseline and at 6 months. Superimposition will identify the difference or change in crestal bone level measured in millimeters between baseline and at 6 months. | 6 months |