Effect of Clomiphene Citrate on Uterine Blood Fow in Women With Unexplained Delayed Conception

Study Overview
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Brief Summary
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In a prospective observational study at a university teaching hospital, blood flow indices and serum hormone levels were compared between spontaneous and stimulated cycles in the same group of 50 patients with unexplained delayed conception.

Detailed Description
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In a prospective observational study at a university teaching hospital, the mid-luteal (peri-implantation) endometrial thickness and volume, uterine artery pulsatility index (PI) and resistance index (RI), endometrial and subendometrial vascularization index, flow index, and vascularization flow index, and serum estradiol and progesterone levels were compared between spontaneous and clomiphene citrate stimulated cycles in the same group of 50 patients with unexplained infertility.

Official Title
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Effect of Clomiphene Citrate on Uterine Hemodynamics in Women With Unexplained Infertility

Conditions
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Infertility, Female

Intervention / Treatment
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* Other: Vascularization indices observation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Unexplained infertility Body mass index less than 30 Regular menstruation Normal pelvic examination and ultrasonography Exclusion Criteria: History of pelvic operations including cesarean section History of pelvic inflammatory disease Endometriosis Pelvic pathology including uterine fibroids General disease or medication that could potentially affect pelvic blood flow Smoking

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Vascularization indices observation|The mid-luteal endometrial thickness and volume, uterine vascularization indices of uterine artery pulsatility index and resistance index, endometrial and subendometrial vascularization index, flow index, and vascularization flow index, and serum estradiol and progesterone levels were calculated in spontaneous then stimulated cycles in the same group of infertile patients|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Flow index of the endometrial region | Flow index of the endometrial region was measured by a researcher | Day 22 to 24 of the menstrual cycle | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vascularization index of the endometrial region | Vascularization index of the endometrial region was measured by a researcher | Day 22 to 24 of the menstrual cycle | 
| Vascularization flow index of the endometrial region | Vascularization flow index of the endometrial region was measured by a researcher | Day 22 to 24 of the menstrual cycle | 
| Vascularization flow index of the sub-endometrial region | Vascularization flow index of the sub-endometrial region was measured by a researcher | Day 22 to 24 of the menstrual cycle | 
| Flow index of the sub-endometrial region | Flow index of the sub-endometrial region was measured by a researcher | Day 22 to 24 of the menstrual cycle | 
| Vascularization index of the sub-endometrial region | Vascularization index of the sub-endometrial region was measured by a researcher | Day 22 to 24 of the menstrual cycle |