linjc16/ctgov huggingface dataset:
Laparoscopic Bariatric Surgery: Impact of Deep Neuromuscular Block on Surgical Conditions

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine whether deep neuromuscular blockade compared to moderate neuromuscular blockade may improve the surgical conditions in patients undergoing laparoscopic bariatric surgery.

Official Title
-----------------
Laparoscopic Bariatric Surgery: Impact of the Level of Neuromuscular Blockade on Surgical Conditions - Comparison Between Moderate and Deep Neuromuscular Blockade

Conditions
-----------------
Bariatric Surgery, Laparoscopic Bariatric Surgery, Robotic Bariatric Surgery, Gastric Bypass, Morbid Obesity

Intervention / Treatment
-----------------
* Drug: rocuronium


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patient between 18 and 64 years indication for bariatric surgery accordingly to HAS patient undergoing laparoscopic or robotic gastric bypass surgery written informed consent affiliation to social security Non-inclusion Criteria: known hypersensibility to any of the drugs used during this study absence of written informed consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 64 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Moderate rocuronium neuromuscular blockade<br>rocuronium bolus is given if needed to maintain moderate neuromuscular blockade (TOF-count 2-4) during gastrojejunal anastomosis | Drug: rocuronium<br> <br> |
| Experimental: deep rocuronium neuromuscular blockade<br>rocuronium bolus is given if needed to maintain deep neuromuscular blockade (here defined as a Posttetanic Count 1 - 5) during gastrojejunal anastomosis | Drug: rocuronium<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improvement of surgical conditions | The surgical conditions will be evaluated with the King Score (M. King et al Anesthesiology 2000; 93: 1392 - 97). This score is a 4-point score. The evaluation will be done by the surgeon who is blinded. An improvement of at least 1-point will be considered as clinical relevant. | 15 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pneumoperitoneum generated pressure | Concomitantly to the evaluation of the surgical conditions the pneumoperitoneal pressure (in mm Hg) generated by the Carbon dioxide insufflation will be registrated. | 15 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
bariatric surgery, surgical conditions, deep neuromuscular blockade
How to Report Postoperative Outcomes After a Paediatric Cardiac Surgery ?

Study Overview
=================
Brief Summary
-----------------
Congenital heart disease is a common abnormality in newborns. The marked improvement in the surgical management of congenital heart disease has led to a reduction in postoperative mortality, historically a quality criterion for surgical and resuscitation management. With the improvement of medical knowledge and surgical techniques, mortality is no longer a single quality criterion for a center and the search for other quality criteria is essential.

Official Title
-----------------
How to Report Postoperative Outcomes After a Paediatric Cardiac Surgery ?

Conditions
-----------------
Congenital Heart Disease in Children

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Minor patients, under the age of 18 operated at the HUS between 01/01/2010 and 03/31/2022 for transposition surgery of the great vessels (arterial switch) with or without CIV; or isolated ventricular septal closure Child or holders of parental authority who do not object to the reuse of their data for scientific research purposes. Exclusion criteria: Transposition surgery of the great vessels associated with coarctation of the aorta, pulmonary stenosis or any other complex malformation Surgical technique different from the arterial switch for the transpositions of the great vessels Closure of interventricular communication associated with another complex heart malformation (tetralogy of Fallot, atrioventricular canal, right ventricle with double outlet, etc.) Child or holders of parental authority who have expressed their opposition to the reuse of their data for scientific research purposes.

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 17 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Retrospective analysis of the quality criteria described in the literature after pediatric cardiac surgery by studying their behavior within a local cohort within the University Hospitals of Strasbourg |  | Files analysed retrospectively from January 01, 2010 to March 31, 2022 will be examined | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Congenital Heart Disease, Abnormality in newborns
Zenith® Dissection Clinical Trial

Study Overview
=================
Brief Summary
-----------------
The Zenith® Dissection Clinical Trial is a clinical trial approved by US FDA to study the safety and effectiveness of the Zenith® Dissection Endovascular System in the treatment of acute, complicate Type B aortic dissection.

Official Title
-----------------
Use of the Zenith® Dissection Endovascular System in the Treatment of Patients With Acute, Complicated Type B Aortic Dissection

Conditions
-----------------
Aortic Dissection

Intervention / Treatment
-----------------
* Device: Endovascular Treatment (Zenith)


Participation Criteria
=================
Eligibility Criteria
-----------------
Exclusion Criteria: Age < 18 years; Other medical condition (e.g., cancer, congestive heart failure) that may cause the patient to be non-compliant with the Clinical Investigation Plan, confound the results, or is associated with limited life expectancy (i.e., less than 2 years); Pregnant, breast-feeding, or planning on becoming pregnant within 60 months; Unwilling or unable to comply with the follow-up schedule; Inability or refusal to give informed consent; Simultaneously participating in another investigative device or drug study. (The patient must have completed the primary endpoint of any previous study at least 30 days prior to enrollment in this study.); Additional medical restrictions as specified in the Clinical Investigation Plan; or Additional anatomical restrictions as specified in the Clinical Investigation Plan.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Endovascular<br>Endovascular Treatment (Zenith) | Device: Endovascular Treatment (Zenith)<br>* Instead of making a large incision in the chest, the physician makes a small incision near each hip to insert, and guides the study device(s) into place in the aorta.<br>* Other names: Stent-graft;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants With Freedom From Major Adverse Events | Primary safety : Major adverse events include: myocardial infarction, chronic renal insufficiency/chronic renal failure requiring dialysis, bowel ischemia, stroke, paraplegia or paraparesis, and prolonged ventilator support | 30 days | 
| Survival Rate at 30 Days | Primary effectiveness endpoint is freedom from all cause mortality at 30 days | 30 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Aorta, Thoracic, Aortic dissection, Rupture, Type B, DeBakey type III, Endovascular
Vestibular Pain Interactions

Study Overview
=================
Brief Summary
-----------------
The goal is to establish the practical usefulness of vestibular stimulation for modulating pain perception and to describe the possible mechanisms that could underlie neural vestibular-somatosensory interactions.

Official Title
-----------------
Modulation of Pain Responses by Vestibular Stimulation. A Contact Heat Evoked Potential Study.

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Procedure: Quantitative sensory testing
* Procedure: CHEPS
* Procedure: 3D Turntable
* Procedure: Vection stimulation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Weight: 50 - 100 kg Height: 155 - 185 cm Male subjects 18 years to 60 years of age Sufficient command of German language Written informed consent by the participant after information about the project Without any known history of neurological disease (especially motor, somatosensory disorders, peripheral neuropathies). Right-handedness Exclusion Criteria: Intellectually or mental impaired subjects Drug abuse Chronic alcohol consumption No use of marihuana 24h before measurements. No history of vestibular or auditory disorders. Diabetes mellitus Participants of other studies during study period and 30 days prior to study begin Any regular concomitant medication Abnormal QST parameters at the baseline measurement. Absent CHEPs-Potentials at the baseline measurement.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Vestibular Pain interactions<br> | Procedure: Quantitative sensory testing<br>* Measurement of warm and cold detection and pain thresholds<br>* Other names: QST;Procedure: CHEPS<br>* Measurement of amplitude and latency of cortically evoked potentials<br>* Other names: Contact heat evoked potentials;Procedure: 3D Turntable<br> <br> Procedure: Vection stimulation<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain thresholds | The change in heat or cold pain threshold after physical vestibular stimulation and vection stimulation | After study inclusion, Day1 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
quantitative sensory testing, contact heat evoked potentials, vection stimulation, 3D-turntable, Volunteers
Endoscopic Capillary Oximetry for Tumor Diagnosis in Head and Neck Cancer

Study Overview
=================
Brief Summary
-----------------
Endoscopy is a standard part of the evaluation of patients with head and neck cancer used for determining the extent of tumor involvement. However, not all areas involved by tumor are apparent visually. Preliminary results indicate that compared with normal tissues, tumors have abnormal levels of capillary oxygenation. The purpose of this study is to determine the ability of non-pulsatile visible light tissue oxygen monitoring to differentiate normal and tumor tissue based on capillary oxygenation during endoscopy Should this be possible, this method could be used to mark tumor extent and invasion, even when that invasion is up to 5mm blow the tissue surface.

Official Title
-----------------
Endoscopic Capillary Oximetry for Tumor Diagnosis in Head and Neck Cancer

Conditions
-----------------
Head and Neck Cancer

Intervention / Treatment
-----------------
* Device: Oximeter


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria:All patients with newly diagnosed head and neck cancer as well as those being seen for routine follow up with no evidence of current disease and healthy volunteers are eligible for this study.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Oximeter|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Calcium Channel Splice Variant Expression in Cardiovascular Disease and Aging

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to learn what changes in blood vessel contraction may occur as a result of a disease of the vessel that requires surgery. The study will examine the calcium channels present in the vessels being operated on, and the genes that may alter blood vessel function. Possible variation in these genes may change the kind of calcium channels present in blood vessels.

Detailed Description
-----------------
The goal of this study is to learn more about how blood vessels function and the mechanism that causes them to contract. The study will investigate the natural history of diseased blood vessel tissue and the calcium channels in the muscle part of the blood vessel. The study will also examine how genetics influences cardiovascular disease and its causes and treatments. Patients scheduled for vascular surgery will be approached to participate in this study. During surgery, tissue fragments of diseased and marginal tissue will be obtained. A blood sample will be obtained at either the time of surgery or consent and genomic DNA will be extracted.

Official Title
-----------------
Calcium Channel Splice Variant Expression in Cardiovascular Disease and Aging

Conditions
-----------------
Atherosclerosis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Ages 21 and older Scheduled for vascular surgery Exclusion Criteria: Unwillingness to be subjected to diagnostic and/or therapeutic procedures that are deemed not necessary for clinical management Volunteers deemed too fragile to participate in the study by the principal investigator (PI) or the attending physician Inability to obtain informed consent from either the volunteer or the responsible party (durable power of attorney [DPA]) for the volunteer, with the volunteer's assent

Ages Eligible for Study
-----------------
Minimum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
vascular aging, vascular surgery, arterial aging, surgical tissue, Aging
Effect of Local Injury on Implantation

Study Overview
=================
Brief Summary
-----------------
Local injury on two sights of endometrium are performed in 60 patients in their first IVF cycle and implantation rate are compared with fresh cycles without local injury.

Detailed Description
-----------------
Low implantation rate is still a major concern in ART cycles. It has been reported that local injury to endometrium may improve endometrial receptivity and implantation rate. A total of 120 patients in first IVF cycles, who are stimulated with long protocol, are randomly divided into two groups. In one group, on the day of oocyte retrieval, local injury to endometrium with a Novak curet to anterior and posterior wall of endometrium are performed and in the other group no interventions are done. After fresh embryo transfers, implantation and clinical pregnancy rates are compared between two groups.

Official Title
-----------------
Effect of Local Injury to Endometrium on the Day of Oocyte Retrieval in First IVF Cycle on Implantation Rate.

Conditions
-----------------
Implantation Rate

Intervention / Treatment
-----------------
* Procedure: local injury


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age < 35 First IVF cycle Long protocol should be used for stimulation Exclusion Criteria: Day 3 FSH > 10

Ages Eligible for Study
-----------------
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: local ingury<br>In one group, on the day of oocyte retrieval, local injury to endometrium with a Novak curet to anterior and posterior wall of endometrium are performed. | Procedure: local injury<br>* In one group, on the day of oocyte retrieval, local injury to endometrium with a Novak curet to anterior and posterior wall of endometrium are performed<br>* Other names: it does not have other name;|
| No Intervention: control<br>in 60 patients routine IVF are performed | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| implantation rate |  | 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| clinical pregnancy rate |  | 4 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
local injury, implantation rate, endometrial receptivity, IVF
Effects of Dietary Protein on Undesirable Postprandial Events in Overweight Subjects

Study Overview
=================
Brief Summary
-----------------
Dietary protein differing by their amino acid composition could modulate undesirable metabolic and functional responses to a meal rich in saturated fat and sugars. This study aims at examining the specific effects of dairy protein with different cysteine contents on the postprandial undesirables effects elicited by the ingestion of a high fat meal in overweight subjects.

Conditions
-----------------
Overweight

Intervention / Treatment
-----------------
* Dietary Supplement: Postprandial metabolic and functional measures


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: BMI between 25 and 30 Waist circumference > 94 cm Exclusion Criteria: Allergy to milk protein Abusive drug consumption Smoking Hypertension, diabetes High level of physical activity

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Casein<br>Protein source in the high fat meal is casein | Dietary Supplement: Postprandial metabolic and functional measures<br>* After ingestion of a high fat meal containing the different protein sources, the subjects undergo a series of measures of endothelial dysfunction and blood and urine sampling for the assessment of proinflammatory cytokines levels and metabolomics determinations.<br>|
| Experimental: Milk soluble protein<br>Protein source in the high fat meal are milk soluble protein | Dietary Supplement: Postprandial metabolic and functional measures<br>* After ingestion of a high fat meal containing the different protein sources, the subjects undergo a series of measures of endothelial dysfunction and blood and urine sampling for the assessment of proinflammatory cytokines levels and metabolomics determinations.<br>|
| Experimental: Alpha lactalbumin<br>Protein source in the high fat meal is alpha-lactalbumin | Dietary Supplement: Postprandial metabolic and functional measures<br>* After ingestion of a high fat meal containing the different protein sources, the subjects undergo a series of measures of endothelial dysfunction and blood and urine sampling for the assessment of proinflammatory cytokines levels and metabolomics determinations.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Endothelial dysfunction |  | 0-2-4-6 hours (after meal ingestion) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postprandial inflammation |  | 0-0.5-1-1.5-2-3-4-6 hours (after meal ingestion) |