Diagnostics for the Reperfusion Injury Following MI

Study Overview
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Brief Summary
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The primary purpose of this study is to correlate new cardiac imaging modalities (2D, 3D echocardiography, contrast echocardiography, strain analysis and cardiac MRI) to biochemical parameters as the L-arginine-nitric oxide pathway and inflammatory cascades to characterize the reperfusion injury following myocardial infarction and thus providing a basis for further diagnostic and therapeutic approaches.

Detailed Description
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By reperfusion of ischemic myocardium further tissue damage occurs (ischemia / reperfusion injury). Various contributing mechanisms have been discussed in experimental studies, e.g. disturbances in coronary microcirculation and consecutive induction of inflammatory cascades involving formation of reactive oxygen species. The ischemia / reperfusion injury causes diastolic and regional as well as global systolic dysfunction. The time course of the reperfusion injury within the first hours after reperfusion and its effects on the global geometry of the left ventricle have not been investigated so far. In the present study a comprehensive morphological and functional characterisation of the ischemia / reperfusion injury in the acute phase is performed. New cardiac imaging modalities (2D, 3D echocardiography, contrast echocardiography, strain analysis and cardiac MRI)and biochemical parameters including the L-arginine-nitric oxide pathway and inflammatory cascades are applied. Hereby morphological and biochemical markers for the functional recovery of myocardial function should be identified.

Official Title
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New Imaging and Diagnostic Techniques for the Assessment of Reperfusion Injury in Myocardial Infarction.

Conditions
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Reperfusion Injury

Intervention / Treatment
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* Drug: contrast echocardiography
* Procedure: 2D and 3D echocardiography
* Procedure: cardiac MRI
* Procedure: blood sampling


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with acute ST elevation myocardial infarction and consecutive percutaneous coronary intervention of the infarct-related artery (first myocardial infarction and recurrent myocardial infarction, as long as infarct-related artery is occluded for the first time) written informed consent or 30 patients with stable CAD (control group 1) or 30 healthy volunteers regarding cardiovascular diseases (control group 2) Exclusion Criteria: minors incompetent persons pregnant and lactating moderate to severe renal insufficiency defined by an GFR < 60 ml/kg/m2 missing written consent other reasons complicating a clinical reevaluation and/or coronary angiography

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>- patients with acute ST elevation myocardial infarction and consecutive percutaneous coronary intervention of the infarct-related artery | Drug: contrast echocardiography<br>* directly after PCI, at 24 h after PCI, before discharge and at 6 months<br>* Other names: with luminity or sonovue;Procedure: 2D and 3D echocardiography<br>* directly after PCI, at 24 h after PCI, before discharge and at 6 months<br>Procedure: cardiac MRI<br>* before discharge and after 6 months<br>Procedure: blood sampling<br>* routine lab work plus infarction and inflammation biomarkers 1: before PCI, after PCI, at 34 hours, at discharge, at 6 months 2 and 3: one blood sample in total before PCI in 2 and at any time in 3<br>|
| 2<br>- 30 patients with stable CAD (control group 1) | Procedure: blood sampling<br>* routine lab work plus infarction and inflammation biomarkers 1: before PCI, after PCI, at 34 hours, at discharge, at 6 months 2 and 3: one blood sample in total before PCI in 2 and at any time in 3<br>|
| 3<br>- 30 healthy volunteers regarding cardiovascular diseases (control group 2) | Procedure: blood sampling<br>* routine lab work plus infarction and inflammation biomarkers 1: before PCI, after PCI, at 34 hours, at discharge, at 6 months 2 and 3: one blood sample in total before PCI in 2 and at any time in 3<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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myocardial infarction, reperfusion injury, echocardiography, magnetic resonance imaging, inflammation, nitric oxide