Preservation of Spontaneous Breathing in Patients Undergoing Thoracoscopic Surgery

Study Overview
=================
Brief Summary
-----------------
the aim of this study is to evaluate the advantages of the non-intubation compared with intubation anesthesia on enhanced recovery after thoracoscopic surgery

Detailed Description
-----------------
All patients will be screened to determine eligibility for study entry, and the patients who meet the eligibility requirements will be informed about the study and potential risks. After giving written informed consent, The patients were randomly divided into non-intubation group and intubation group

Official Title
-----------------
Comparison of Thoracic Paravertebral Nerve Block Combined Laryngeal Mask Airway With Preservation of Spontaneous Breathing Versus General Anesthesia Using Double-lumen Endobronchial Intubation in Patients Undergoing Thoracoscopic Surgery:

Conditions
-----------------
Thoracoscopic Surgery

Intervention / Treatment
-----------------
* Procedure: General anesthesia with preservation of spontaneous breathing


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age 18-69 years old Body mass index (BMI) was 18-24 kg / m2 American Society of Anesthesiologists' physical classification class I-II The preoperative pulmonary function was normal Exclusion Criteria: Severe cardiopulmonary disease Severe nervous system diseases Severe blood system diseases Severe liver and kidney dysfunction Conversion to thoracotomy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 69 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: non-intubation group: thoracic paravertebral nerve block was performed before anesthesia induction,after anesthesia induction laryngeal mask airway(LMA) is placed. intubation group:were given routine induction with double-lumen endotracheal intubation.
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: spontaneous breathing anesthesia non-intubation group<br>In this group all the patients with spontaneous breathing anesthesia | Procedure: General anesthesia with preservation of spontaneous breathing<br>* non-intubation group, thoracic paravertebral nerve block was performed before anesthesia induction,when the BIS value drops to between 40 and 60, laryngeal mask airway(LMA) is placed,and observation of breathing<br>|
| No Intervention: general anesthesia with double-lumen endotracheal intubation group<br>In this group all the patients with tradition anesthesia with double-lumen endotracheal intubation | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the hospitalized stay | the hospitalized stay | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual analogue score (VAS) after operation; | Visual analogue score (VAS) was compared between the two groups | 1 year | 
| The postoperative complications | postoperative nausea and vomiting(PONV), pulmonary infection, atelectasis, sore throat, hoarseness | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Spontaneous breathing anesthesia