Measurement of Respiratory Admittance for Pediatric Asthma Diagnosis

Study Overview
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Brief Summary
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The purpose is to characterize the change of respiratory admittance induced by salbutamol inhalation in children and young adults. A variation threshold will be fixed to distinguish asthmatic and healthy subjects. This project could allow a better identification of asthmatic individuals needing a treatment, a reduction of morbidity of asthma, a reduction of unnecessary treatments administered in individuals with respiratory but not asthmatic symptoms, a better comprehension of bronchial hyperreactivity and its role in asthmatic disease.

Official Title
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Measurements of Change of Respiratory Admittance Induced by Salbutamol for Pediatric Asthma Diagnosis

Conditions
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Asthma

Intervention / Treatment
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* Drug: Salbutamol
* Procedure: Forced oscillation technique
* Procedure: Plethysmography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Asthmatic children group: Several episodes of paroxysmal wheezes, spontaneous or after exercise, without bronchial-pulmonary infection Absence of bronchodilator taking during last 12 hours Absence of reported intolerance to adrenergic substances Parental authorization and consent of child to participate to the study Control children group: - Parental authorization and consent of child to participate to the study Control adult group: - Consent to participate to the study Exclusion Criteria: Control children and adult groups: At least 2 episodes of wheezes during breathing Several wheezes, abnormal breathlessness, cough during physical exercise Asthma diagnosed by family doctor Administration of drugs to treat asthma Eczema or food allergy at inclusion Episode of cough for longer than 6 weeks, without bronchial infection Bronchitis, throat infection, rhino-pharyngitis during last 15 days Paleness or cyanosis with loss of consciousness when the child was a baby or during an exercise

Ages Eligible for Study
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Minimum Age: 3 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Asthma child<br> | Drug: Salbutamol<br>* bronchodilation obtained with 2 inhalations of salbutamol (100 µg per dose) with inhalation chamber<br>* Other names: Ventoline;Procedure: Forced oscillation technique<br>* before and after bronchodilation<br>Procedure: Plethysmography<br> <br> |
| Experimental: Control adult<br> | Drug: Salbutamol<br>* bronchodilation obtained with 2 inhalations of salbutamol (100 µg per dose) with inhalation chamber<br>* Other names: Ventoline;Procedure: Forced oscillation technique<br>* before and after bronchodilation<br>Procedure: Plethysmography<br> <br> |
| Experimental: Control child<br> | Drug: Salbutamol<br>* bronchodilation obtained with 2 inhalations of salbutamol (100 µg per dose) with inhalation chamber<br>* Other names: Ventoline;Procedure: Forced oscillation technique<br>* before and after bronchodilation<br>Procedure: Plethysmography<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ventilatory mechanical impedance | Measured with Forced oscillation technique. 2 measures at basal status at 10 min interval for reproducibility and after 10 min broncodilation with salbutamol | day 0 | 
| Thoracic gas volume | Measured with Plethysmography. | day 0 |