linjc16/ctgov huggingface dataset:
Application of High Flow Nasal Cannula for Prevention of Post-extubation Atelectasis in Children Undergoing Surgery

Study Overview
=================
Brief Summary
-----------------
postoperative atelectasis observation by ultrasound after application of high flow nasal cannula oxygenation

Detailed Description
-----------------
After surgery, postoperative atelectasis observation by ultrasound grading comparison between application of conventional nasal prong and high flow nasal cannula device

Official Title
-----------------
Seoul National University Hospital Department of Anesthesiology and Pain Medicine

Conditions
-----------------
Atelectasis

Intervention / Treatment
-----------------
* Procedure: high flow nasal cannula oxygenation
* Procedure: nasal prong


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: general anesthesia Exclusion Criteria: preterm bronchopulmonary dysplasia upper respiratory infection history respiratory disease cardiac surgery

Ages Eligible for Study
-----------------
Minimum Age: 1 Day
Maximum Age: 2 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: nasal prong<br>conventional nasal prong application after the surgery in postanesthetic care unit (PACU) | Procedure: nasal prong<br>* conventional nasal prong application in PACU<br>|
| Experimental: high flow nasal cannula oxygenation<br>high flow nasal cannula application after the surgery in postanesthetic care unit (PACU) | Procedure: high flow nasal cannula oxygenation<br>* high flow nasal cannula application in PACU<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| lung sound score | 0: Normal aeration (N): presence of lung sliding with A lines or fewer than two isolated B lines Moderate loss of lung aeration: multiple well-defined B lines (B1 lines) Severe loss of lung aeration: multiple coalescent B lines (B2 lines) Lung consolidation (C): the presence of a tissue pattern characterized by dynamic air | 30 minutes after arrival of postanesthetic care unit |
Hypofractionated Stereotactic Linear Accelerator Radiotherapy of Uveal Melanoma

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to assess the safety and efficacy of hypofractionated stereotactic LINAC radiotherapy with 10 fractions at 6 Gy per fraction at the 80% isodose for the planning target volume (PTV) in patients with uveal melanoma. Patients will be followed-up for 10 years after radiotherapy regarding local tumor control, visual acuity, secondary complications and survival.

Official Title
-----------------
Safety and Efficacy of Hypofractionated Stereotactic Linear Accelerator Radiotherapy of Malignant Melanoma of the Uvea

Conditions
-----------------
Uveal Melanoma

Intervention / Treatment
-----------------
* Radiation: Hypofractionated linear accelerator radiotherapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The initial height of the melanoma is 7 mm or higher. Juxtapapillary and/or juxtamacular melanomas with a height of 3 mm or higher and if the central tumor distance to the optic disc and/or the macula is 3 mm or less. If other forms of conservative treatment of the melanoma are not possible. Exclusion Criteria: Prior/Concomitant Treatment. Extrascleral tumor extension is present. If the presence of neovascular glaucoma is detected before treatment. If metastasis is detected at baseline. Previous participation in any study of investigational drugs within 3 month preceding day 0. Pregnant women are not allowed to participate in the study.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Hypofractionated LINAC radiotherapy<br> | Radiation: Hypofractionated linear accelerator radiotherapy<br>* 10 fractions of stereotactic linear accelerator radiotherapy with 6 Gy per fraction at the 80% isodose for the planning target volume.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| local tumor control (tumor dimensions; secondary complications; visual acuity; survival |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| histological assessment of the fraction of living cells in eyes requiring secondary enucleation |  |  |
Evaluation of the Change in Length of the Leg in Children After Treatment of Femur Fractures.

Study Overview
=================
Brief Summary
-----------------
Femur fractures are a common injury in the Pediatric population. Despite their high incidence little do we know about the long term implications on the bones' length. Our main goal is to clarify this obscure issue by assessing the femoral and tibial length as determined by the fractures, measuring techniques and treatment modalities

Official Title
-----------------
Evaluation of the Change in Length of the Femur and Tibia in Children After Treatment of Femur Fractures With External Fixators, Plaster of Paris or Internal Fixation

Conditions
-----------------
Fractures

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Males between the ages 0-16. Females between the ages 0-14. Signed Informed consent Exclusion Criteria: A refusal by the patient or his legal guardian to continue the follow-up with the Pediatric Orthopedic clinic, or to have the CT scanograms. Patients with severe contractures in the lower extremities Patients with multiple lower extremity fractures Pregnancy

Ages Eligible for Study
-----------------
Maximum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Social Determinants of Health in Diabetes Outcomes

Study Overview
=================
Brief Summary
-----------------
This is a cross-sectional study of six hundred adults with type 2 diabetes, (300 White and 300 African-American) who will be recruited from two primary care sites to determine how social determinants of health impact diabetes outcomes. The first aim is to investigate the role of psychosocial factors and SES on diabetes care processes and outcomes. The second aim is to investigate the influence of community and neighborhood characteristics on diabetes care processes and outcomes. Finally, we will examine the contribution of social determinants of health to ethnic differences in diabetes care processes and outcomes. Clinical and metabolic measures will be abstracted from the electronic medical records. Outcome variables include hemoglobin A1c, blood pressure, LDL-Cholesterol and quality of life.

Official Title
-----------------
Social Determinants of Health as Explanatory Factors for Ethnic Disparities in Diabetes Outcomes

Conditions
-----------------
Diabetes Mellitus, Type 2

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical diagnosis of type 2 diabetes Able to communicate in English Exclusion Criteria: Mental confusion on interview suggesting significant dementia Alcohol or drug abuse/dependency Active psychosis or acute mental disorder

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HbA1C |  | Within 3 months prior to the assessment | 
| Quality of life |  | Within a month of completely the assessment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood pressure |  | Most recent to assessment date | 
| Low density lipoprotein (LDL) Cholesterol |  | Most recent to assessment date |
Anterior Wedge in Patients With Osteoarthritis Hip

Study Overview
=================
Brief Summary
-----------------
Ostearthritis is a great source of pain. In symptomatic hip the pain can lead the major disability and poor quality of life. Understand the musculoskeletal factores can lead to a better clinical management. The muscle strenghening of posterolateral complexo of hip is a important consideration. General Objective: Perform a Kinetic analysis 2D using na anterior wedge. Specific objective: Analyze the influence of posterolateral hip complex. Controlled clinical trial, composed by 30 individuals with and without osteoarthritis of hip e will be used a tools; Analogic Visual Scale, manual dynamometry to analyze force and kinetic analyze of gait through of Myovídeo analysis software.

Official Title
-----------------
Effect of Anterior Wedge Use in Patients With Osteoarthritis Hip

Conditions
-----------------
Gait, Frontal

Intervention / Treatment
-----------------
* Other: Application of the anterior wedge


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Sedentary individuals Both genders Age equal to or greather than 50 years Diagnosis of osteoarthritis level II and III Exclusion Criteria: fractures Neuromuscular diseases Other diseases of hip

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control Group<br>Patient will undergo gait analysis | |
| Experimental: Experimental group<br>Patient will undergo gait analysis with use of anterior wedge | Other: Application of the anterior wedge<br>* Application of anterior wedge in tennis<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Inproved performance of the gluteus maximus | Extent moment will be assessed by gait analysis | 24 hours |
Automated Volume Assessment of Acute Stroke

Study Overview
=================
Brief Summary
-----------------
Stroke is a common disease. It is increasingly managed in non-specialized centers. The volume of the lesion, evaluated on the diffusion weighted imaging, is a prognostic factor of clinical progression and is useful for the treatment decision. There is therefore a real interest in having a reliable software able to detect the stroke and evaluate the volume of the cerebral infarction. The aim is to provide rapid information to the interventional neuroradiologist and optimize the care of the patient. The Alberta Stroke Program Early Computed Tomography Score currently used to predict response to treatment divides the territory of the middle cerebral artery. It has a few limitations, it is unreproducible and concerns only the territory of the middle cerebral artery. Manual volumetry is a long and also not very reproducible technique. The aim of our study is to evaluate the reproducibility and diagnostic performances of the automated segmentation software based on the diffusion weighted imaging sequence, and to compare it to manual and semi-automatic measurements.

Official Title
-----------------
Evaluation of Infarct Volumetric Software in Strokes of Less Than 24 Hours

Conditions
-----------------
Stroke, Software Verification, Diffusion Weighted MRI, Neuroimaging

Intervention / Treatment
-----------------
* Diagnostic Test: specific MRI sequences


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients admitted for a recent neurological deficit (less than 24 hours), suspected for a stroke. Non inclusion criteria : Pregnant or breastfeeding women Patients with absolute contraindications to MRI

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| ischemic stroke<br>all patients with a suspicion of ischemic stroke | Diagnostic Test: specific MRI sequences<br>* MRI with B 2000 of diffusion weighted imaging and the coefficient of apparent diffusion<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Automated volume assessment of acute stroke | Our objective is to compare several volumetric techniques (manual, semi-manual, automatic) based on the B 2000 of diffusion weighted imaging and the coefficient of apparent diffusion. We will also evaluate the correlation between the volumes obtained by the different techniques and the final volume of FLAIR infarction and diffusion in a subgroup of patients for whom a follow-up MRI is feasible. | 1 hour |
Bilateral Erector Spinae Plane Block in Paediateric Cardiac Surgery

Study Overview
=================
Brief Summary
-----------------
ultrasound guided erector spinae plane block will be done for childern under going midline sternotomy for cardiac surgery. It is a novel block which is suspected to give powerful analgesia, decrease anaesthetic consumption and decrease awareness on cardiac bypass

Official Title
-----------------
Bilateral Erector Spinae Plane Block in Paediateric Cardiac Surgery, Randomized Study

Conditions
-----------------
Pain Management

Intervention / Treatment
-----------------
* Procedure: PCA
* Procedure: ESP


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: elective surgery childern between 4 and 10 years Exclusion Criteria: emergency infection at injection site allergy to local anaestheics

Ages Eligible for Study
-----------------
Minimum Age: 4 Years
Maximum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: patients will be randomly assigned into one of two groups, control group will receive patient controlled analgesia, and intervention group will receive ESP Block .
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: control group<br> | Procedure: PCA<br>* Patient controlled analgesia<br>|
| Active Comparator: ESP Group<br> | Procedure: ESP<br>* erector spinae plane block<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| visual analogue score | pain scores will be assessed by anaesthesia and ICU nurse. zero mean no pain an 10 indicate the worst pain. | 48 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| intraoperative anaesthetic consumption |  | 6 hours |
Cortical Visual Impairment and Visual Attentiveness

Study Overview
=================
Brief Summary
-----------------
This study will investigate the effect of enhanced visual and cross-modal environments upon the visual attentiveness of multiply handicapped children diagnosed with Cerebral Palsy (CP) and Cortical Visual Impairment (CVI). Research Hypothesis Adapted visual environments which present controlled auditory, tactile, proprioceptive or contrasting visual background stimulation will enhance the visual attentiveness to a given visual stimulus of children diagnosed with CP and CVI. Systematic, repetitive, visual stimulation over time, improves the visual attentiveness and/or visual-motor responses of CP-CVI children. The analysis of additional behavioral responses to visual stimuli is a critical component in evaluating the perceptual development of visual attention in CP-CVI children. Use of Noldus: The Observer, an advanced objective computerized observation program, will enable precise detection of the neurobehavioral responses of the participants. Both overt and covert responses will be observed, analyzed and correlated to identify the level of attention of each participant.

Official Title
-----------------
Cortical Visual Impairment and Visual Attentiveness: The Effect of Visual and Cross-Modal Environments on Children Diagnosed With Cerebral Palsy and Cortical Visual Impairment

Conditions
-----------------
Cerebral Palsy, Cortical Visual Impairment

Intervention / Treatment
-----------------
* Behavioral: cross-modal sensory stimulation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: two to twelve years of age diagnosis of: CP, mental retardation (MR) and CVI (Control group participants without visual disability) Exclusion Criteria: N/A

Ages Eligible for Study
-----------------
Minimum Age: 2 Years
Maximum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Diagnosis: CP, moderate to severe MR and CVI | Behavioral: cross-modal sensory stimulation<br>* comparison of participant response to unimodal visual stimulation and to bimodal sensory stimulation<br>|
| Experimental: 2<br>Diagnosis: CP, Moderate to severe MR, no visual impairment | Behavioral: cross-modal sensory stimulation<br>* comparison of participant response to unimodal visual stimulation and to bimodal sensory stimulation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Eye Movements |  | within the testing session | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Other behavioural responses |  | within the testing session |
Primary Lesion Treatment for Bone Metastases

Study Overview
=================
Brief Summary
-----------------
This study will carry out a prospective cohort study to study the effect of different primary leison treatment modes on disease control, quality of life, economic cost and survival period of patients with bone metastases from breast cancer and lung cancer by giving radiotherapy or palliative surgery or not giving local treatment for the primary lesion in patients with bone metastases from breast cancer or lung cancer

Official Title
-----------------
Study on Primary Lesion Treatment for Patients With Bone Metastases

Conditions
-----------------
Bone Metastases

Intervention / Treatment
-----------------
* Radiation: radiotherapy
* Procedure: palliative surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: HR positive breast cancer patients with bone metastasis or Non-small-cell lung cancer patients with bone metastasis； Aged over 18; ECOG：0-1； Patients who benefit clinically(CR+PR) after 6 months of treatment. Exclusion Criteria: The expected life span is less than 3 months; Have serious cardiovascular and cerebrovascular diseases, blood coagulation dysfunction, and cannot tolerate surgery; Allergies to narcotic drugs; The patient refused the treatment decision of the integrated team.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: radiotherapy<br> | Radiation: radiotherapy<br>* radiotherapy<br>|
| Experimental: palliative surgery<br> | Procedure: palliative surgery<br>* palliative surgery<br>|
| No Intervention: no primary leison treatment<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disease control rate at 1 year | Disease control rate | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression-Free Survival |  | 1 year | 
| Overall Survival |  | 1 year |