Quantitative Renal Uptake Using TC99m DMSA in Hypertensive &/or Diabetic Patients.

Study Overview
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Brief Summary
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the investigators explore the possible role of DMSA to detect renal affection in diabetic &/or hypertensive patients by detecting difference in counts using Tc 99m DMSA in control & diabetic &/or hypertensive patients.

Official Title
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Quantitative Renal Uptake Using TC99m DMSA in Hypertensive &/or Diabetic Patients.

Conditions
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Diabetes Mellitus, Hypertension

Intervention / Treatment
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* Diagnostic Test: DMSA scan


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • Patients with diabetes (type2), weather controlled or not. Patients with essential hypertension. Patients with diabetes & hypertension. Within normal renal function (urea & creatinine). Control cases may be normal individuals (apparently healthy) like donors for renal transplant. Exclusion Criteria: • Patients with abnormal renal function. Patients with diseases known to affect kidney function rather diabetes & hypertension e.g. SLE, heart failure or liver cell failure.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Control<br>control will be subjected to: • Quantitative Tc99m DMSA renal scan using SPECT technique. | Diagnostic Test: DMSA scan<br>* We explore the possible role of DMSA to detect renal affection in diabetic &/or hypertensive patients by detecting difference in counts using Tc 99m DMSA in control & diabetic &/or hypertensive patients.<br>|
| Active Comparator: Diabetic<br>diabetic cases will be subjected to: • Quantitative Tc99m DMSA renal scan using SPECT technique. | Diagnostic Test: DMSA scan<br>* We explore the possible role of DMSA to detect renal affection in diabetic &/or hypertensive patients by detecting difference in counts using Tc 99m DMSA in control & diabetic &/or hypertensive patients.<br>|
| Active Comparator: Hypertensive<br>hypertesive cases will be subjected to: • Quantitative Tc99m DMSA renal scan using SPECT technique. | Diagnostic Test: DMSA scan<br>* We explore the possible role of DMSA to detect renal affection in diabetic &/or hypertensive patients by detecting difference in counts using Tc 99m DMSA in control & diabetic &/or hypertensive patients.<br>|
| Active Comparator: Diabetic & Hypertensive<br>Diabetic & Hypertensive cases will be subjected to: • Quantitative Tc99m DMSA renal scan using SPECT technique. | Diagnostic Test: DMSA scan<br>* We explore the possible role of DMSA to detect renal affection in diabetic &/or hypertensive patients by detecting difference in counts using Tc 99m DMSA in control & diabetic &/or hypertensive patients.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Renal Counts | Quantitative Tc99m DMSA renal scan using SPECT technique will be used to measure renal function. | 2-4 hours |