Correlation Between LR-ACT and Anti Xa Activity During Endovascular Surgery Procedures. AXAES (Anti Xa vs ACT-LR in Endovascular Surgery)

Study Overview
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Brief Summary
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Activated clotting time (ACT) is currently recommended to monitor high concentrations heparin anticoagulation. ACT-LR was specifically designed to measure the activity of low dose of heparin used during endovascular surgery. The correlation between ACT-LR and Anti Xa activity which is considered as the gold standard seems to be debated. Few studies in literature had shown controversial results. These studies were conducted in patients who underwent open as endovascular surgery. However, the ACT monitoring is not recommended in open surgery. In addition, heparin administration protocols are not described and specific to each centre. In this study investigators want to study the correlation between LR-ACT and anti Xa after introducing a heparin protocol during complex endovascular procedures.

Official Title
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Correlation Between LR-ACT and Anti Xa Activity During Endovascular Surgery Procedures.

Conditions
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Aortic Diseases, Arterial Disease, Thrombosis

Intervention / Treatment
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* Biological: Anti Xa activity measurement.


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥ 18 ans Weight ≥ 37,5 kg Patients operated for complex endovascular aortic aneurysm repair deep vein recanalization complex arterial revascularization (TASC D lesions) Patient informed of the study details and who didn't opposed to participate in this research Exclusion Criteria: Known allergy to heparin Known hepatic insufficiency with repercussion on coagulation Thrombocytopenia Known hemostasis disorders Anemia defined HB<8 g/L Pregnant women Persons deprived of their liberty by a judicial or administrative decision Persons subject to psychiatric care Persons admitted to a health or social establishment for purposes other than research Adults subject to a legal protection measure (guardianship, curatorship)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: Anti Xa activity measurement.|Arterial blood samples of 3cc will be taken during the procedure at each ACT. Blood samples will be sent to the lab for anti Xa activity measurement.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between ACT (second) realized in operative room and Anti Xa activity (UI/ml) results provide by the lab. | Following the heparin administration protocol, each ACT measurement will be associated to a blood samples for anti Xa activity measurement. Retrospectively, anti Xa results will be analyze and compare to ACT value which will be report in the operative report. The blood samples will be taken in operative room during endovascular procedures as defined in the protocol. | During surgery - 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Complex aortic endovascular repair, Arterial recanalization, Deep veinous recanalization, Anti Xa, LR-ACT, Heparin, Endovascular procedures