Adaptive Cognitive Training in Healthy Older Adults

Study Overview
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Brief Summary
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Cognitive training has emerged as a promising method to maintain, enhance, and rehabilitate cognitive function in older adults and individuals with dementia. In recent years, such training has become particularly appealing in the clinical context, with many paradigms aimed specifically at adults experiencing various stages of cognitive decline due to Mild Cognitive Impairment, Alzheimer's disease, and vascular dementias. However, basic questions remain. For example, uncertainty persists regarding factors that influence observed improvements as well as the conditions that would maximize transfer and sustainability of training effects. The objective of this study is to evaluate factors that may maximize the benefits of computerized cognitive training in older adults.

Detailed Description
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The study involves 25 sessions of an adaptive cognitive training program, completed over 5 weeks. Pre and post training assessments will evaluate any near and far transfer effects of training.

Official Title
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Adaptive Cognitive Training in Healthy Older Adults

Conditions
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Mild Cognitive Impairment, Mild to Moderate Dementia, Alzheimer's Disease

Intervention / Treatment
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* Other: Computerized cognitive training
* Other: Computerized games


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: English as the maternal or primary spoken language. Good self-reported health (i.e., no cerebro-, or cardio-vascular disease or neurological disease). Normal or corrected-to-normal vision and hearing. Exclusion Criteria: Poor hearing or vision Inadequate understanding of the English language

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Computerized cognitive training<br>Series of gamified tasks. | Other: Computerized cognitive training<br> <br> * Other names: Activate;|
| Placebo Comparator: Computerized game training<br>Series of gamified tasks. | Other: Computerized games<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in ratings on cognitive training survey | This survey aims to assess participant perceptions on cognitive training, and includes a series of related questions, rated on a scale of 1-7. | Baseline, week 5 | 
| Change in neural activity | We will measure resting state as well as task-related EEG responses to determine the effects of cognitive training at the neural level. | Baseline, week 5 | 
| Change in performance on neuropsychological tests | Using a set of standard neuropsychological evaluations, we will measure changes in attention, memory, and executive function following cognitive training. | Baseline, week 5 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in ratings of psychological wellbeing | We will use standardized questionnaires to assess quality of life, in order to measure the influence of cognitive training on factors related to wellbeing. | Baseline, week 5 |