Motion Immune Magnetic Resonance Imaging (MRI)

Study Overview
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Brief Summary
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The purpose of this study is to evaluate our recently developed MRI reconstruction strategy for producing artifact-free neuro and abdominal MRI data. The new reconstruction strategies, including 1) REKAM and 2) MUSE, are capable of effectively removing motion-related artifacts resulting from global and local motion during neuro and free-breathing abdominal MRI scans, without modifying the MRI pulse sequences and protocols that are currently used in clinical scans. The study team aims to recruit 60 subjects across multiple challenge patient populations: 10 healthy young adults (age 20-30) and 10 healthy older adults (aged 50-70) for abdominal MRI, as well as 20 tremor dominant PD patients and 20 children (age 4-8) for brain MRI scans. There are no known risks in taking MRIs and a unique code will be assigned to each participant to protect their PHI.

Official Title
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Examining the Clinical Utility of Motion Immune MRI Across Multiple Patient Populations

Conditions
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Parkinson's Disease

Intervention / Treatment
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* Device: Multiplex Sensitivity Encoding (MUSE)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: subject's age is within one of the following age ranges (4-8, 20-30, or 50-70 years old); male or female; healthy volunteer or diagnosed with PD ; and devoid of the following exclusion criteria. Exclusion Criteria: claustrophobia or other MRI contraindications (including pregnancy); diagnosis for dementia (Alzheimer's, Lewy Body, or Vascular); symptomatic psychotic disorders; depression with psychotic symptoms; other psychotic or schizophrenic disorders; recent neuroleptic treatment; history of cardiovascular disease; history of stroke or Transient Ischemic Attack; cancer (other than skin cancer) within the last three years; hospitalization for neurological/psychiatric condition; significant handicaps (e.g., visual or hearing loss, mental retardation) that would interfere with neuropsychological testing or the ability to follow study procedures; or any other factor that in the investigators' judgment may affect patient safety or compliance.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy Younger Adults<br>Age: 20-30. Gender: male or female. No neurological conditions. | Device: Multiplex Sensitivity Encoding (MUSE)<br>* It is an algorithm for MRI post-processing/image reconstruction (see reference: Chen).<br>|
| Healthy Older Adults<br>Age: 50-70. Gender: male or female. No neurological conditions. | Device: Multiplex Sensitivity Encoding (MUSE)<br>* It is an algorithm for MRI post-processing/image reconstruction (see reference: Chen).<br>|
| Parkinson's disease<br>Gender: male or female. Tremor dominant Parkinson's disease. | Device: Multiplex Sensitivity Encoding (MUSE)<br>* It is an algorithm for MRI post-processing/image reconstruction (see reference: Chen).<br>|
| Healthy Children<br>Age: 4-8. Gender:male or female. No neurological conditions. | Device: Multiplex Sensitivity Encoding (MUSE)<br>* It is an algorithm for MRI post-processing/image reconstruction (see reference: Chen).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rating of image quality (based on 8 criteria) by multiple radiologists (blind to reconstruction method) | The ratings will be compared to compare the quality of images processed with MUSE versus conventional reconstruction methods | 1 day (At time of image analysis) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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MRI