Prognostic of Dysfunctional Breathing in Long Covid: a Follow up Study

Study Overview
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Brief Summary
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Dysfunctional breathing might participate to dyspnoea in long COVID-19. This study investigate the prognosis of patients diagnosed with dysfunctional breathing after SARS-CoV-2 infection in our center.

Detailed Description
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Dysfunctional breathing (DB) with or without hyperventilation syndrome (HVS) as diagnosed using cardiopulmonary exercise test (CPET) was recently demonstrated as an important physiopathological mechanism of persistent dyspnoea in long COVID patients [1]. DB is characterized by specific ventilation pattern on CPET accompanied by respiratory discomfort and/or dyspnea at exercise [2]. Most patients with DB will have undergone some sort a specific physiotherapy retraining [3]. However the prognostic and the predictors of persistence/resolution of DB after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are unknown. The aim of the study is to determine the prognostic of patients diagnosed with DB after SARS-CoV-2 infection, as well as prognosis factors and predictors of persistence/resolution of DB during a prospective follow up visit.

Official Title
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Prognostic of Dysfunctional Breathing in Long Covid: a Follow up Study

Conditions
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COVID-19, Dysfunctional Breathing

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients 14 years or more diagnosis of DB after SARS-CoV-2 at our long covid clinic using a combined approach of symptoms and CPET analysis in the hospitals of Sion, Martigny or Rennaz Inclusion between November 2020 and until the end of October 2021 Exclusion Criteria: Refusal to participate comorbidities preventing the CPET or PFT to be carried out

Ages Eligible for Study
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Minimum Age: 14 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Persistence/resolution of dysfunctional breathing at follow-up visit | defined by persistence/resolution of dyspnea, as compared with patient's baseline (equivalent level of dyspnea as before COVID-19). | 6 to 9 monts from diagnosis | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in ventilatory patterns (tidal volume [VT], breathing frequency [BF] at isowork as compared with baseline |  | 6 to 9 monts from diagnosis | 
| Dispersion of VT and BF during the CPET |  | 6 to 9 monts from diagnosis | 
| Change in ETCO2 and PaCO2 |  | 6 to 9 monts from diagnosis | 
| Qualitative changes (increase/decrease/no change of DB pattern of CPET) |  | 6 to 9 monts from diagnosis | 
| Score HADS changes |  | 6 to 9 monts from diagnosis | 
| Score SF-36 changes |  | 6 to 9 monts from diagnosis | 
| Specific symptom scale changes |  | 6 to 9 monts from diagnosis | 
| Specific work capacity changes questions |  | 6 to 9 monts from diagnosis | 
| Post-COVID Functional Status (PCFS) changes |  | 6 to 9 monts from diagnosis | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COVID-19, Dysfunctional breathing, Hyperventilation syndrome, Sighs, erratic breathing