Sleep Schedules Modifications in Sleep Apnea Patients Treated by nCPAP

Study Overview
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Brief Summary
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In Obstructive sleep apnea (OSA) patients, sleep is disrupted and sleep quality is very poor. The investigators can suppose that with continuous positive airway pressure (CPAP) therapy, there is an improvement in sleep quality, such that patients need less sleep to be fit. Sleep schedules on mid term periods in OSA patients under CPAP therapy has not been studied. The investigators have planned to study sleep schemes before and after CPAP therapy in moderate to severe sleepy OSA patients.

Detailed Description
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In Obstructive sleep apnea (OSA) patients, sleep is disrupted and sleep quality is very poor. The investigators can suppose that with CPAP therapy, there is an improvement in sleep quality, such that patients need less sleep to be fit. Patients often report this fact, but it has not been objectivated. Sleep schedules on mid term periods in OSA patients under CPAP therapy has not been studied. The investigators have planned to study sleep schemes before and after CPAP therapy in moderate to severe sleepy OSA patients. Sleep schemes and physical activity will be studied with actigraphy. Study Design : prospective study. Number of patients supposed to be studied: 190 Methods: Patients Ø OSA patients assessed by polysomnography, showing apnea-hypopnea index > 20, and Epworth Sleepiness Scale Score(ESS) >10 Ø Indication of CPAP therapy Initial Evaluation : Phase 1 ESS BMI Questionnaire : Nottingham health profile Comorbidities -medical therapy Smoking/alcohol Consumption Then, we give an Actigraph (Body Media Sense WearÒ) to the patients, that he has to wear during 7 complete days Phase 2 Actigraphy report Start of CPAP therapy(pressure adjusted according to autoCPAP device report after minimum one night) Second Evaluation, after 3 months under CPAP: Phase 1 § ESS BMI CPAP observance report to calculate mean use/day Questionnaire : Nottingham health profile Actigraph (Body Media Sense WearÒ) to the patients, that he has to wear during 7 complete days Phase 2: after 1 week under CPAP and actigraphy Actigraphy report CPAP observance report CPAP Tolerance Questionnaire Ø

Official Title
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Evaluation of Sleep Schedules Modifications in Moderate to Severe Sleep Apnea Patients Treated by nCPAP

Conditions
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Obstructive Sleep Apnea

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Moderate to severe OSA sleepy (sleepiness assessed by Epworth Sleepiness Scale) indication for CPAP therapy Exclusion Criteria: narcolepsy age < 18 non sleepy Moderate to severe OSA no CPAP treatment required

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| obstructive sleep apnea, CPAP<br>moderate to severe obstructive sleep apnea requiring CPAP therapy | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Total Sleep Time Before and After CPAP Therapy in Obstructive Sleep Apnea Patients | change in Total sleep time before and after CPAP therapy in obstructive sleep apnea patients, assessed by actigraphy | baseline and at 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Physical Activity (Number of Steps/Day)Before and After CPAP Therapy in OSA Patients | Change in Physical activity (number of steps/day)before and after CPAP therapy in OSA patientsevaluated by actigraphy | baseline and at 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Obstructive sleep apnea, CPAP, actigraphy, sleep, physical activity