Assessment of Mandibular Osseous Changes in Patients With End Stage Renal Failure

Study Overview
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Brief Summary
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This study will be observational study. The goal of this study is to evaluate the quality of mandible and to assess the correlation between the jaw bone quality in a sample of Egyptian patients with chronic renal failure and duration of dialysis using CBCT.

Detailed Description
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This study will be observational study. The goal of this study is to evaluate the quality of mandible and to assess the correlation between the jaw bone quality in a sample of Egyptian patients with chronic renal failure and duration of dialysis using CBCT. Twenty-six subjects will be included in this study. These will comprise (13) CKD patients the study group and (13) healthy patients the control group recommended for CBCT imaging for implant placement. The control group will be selected from the Prosthodontic department and Oral Medicine department of Faculty of Oral and Dental Medicine, Cairo University, the study group will be selected from Nephrology and the artificial kidney unit El Kasr -Al Ain Hospital, Cairo University.

Official Title
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Assessment of Mandibular Osseous Changes Using Radiomorphometric Indices By Cone Beam Computed Tomography in Patients With End Stage Renal Failure Versus Normal Population

Conditions
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Diagnosis

Intervention / Treatment
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* Other: CBCT imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: End stage renal failure (in study group) Undergone hemo-dialysis, three times/week (in study group) Duration of dialysis (≥1 year) (in study group) PTH (140-630) Age group (18-40 years) Mandible Free from any other systemic disease affecting the bone quality Egyptian population Exclusion Criteria: Early stage of renal disease Patients with diabetes, hyperthyroidism, postmenopausal osteoporosis Maxilla Other language Completely Edentulous patients.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| study group<br>CBCT imaging of patients with end stage renal failure, undergoing hemo-dialysis | Other: CBCT imaging<br>* CBCT imaging of participants, then take measurement by radiomorphometric indices<br>|
| control group<br>CBCT imaging of medically-free participants | Other: CBCT imaging<br>* CBCT imaging of participants, then take measurement by radiomorphometric indices<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mandibular cortical index(MCI) | Mandibular cortical index (MCI) is a qualitative index that determines the porosity degree of the lower cortical border of the mandible distal to the mental foramen.The lower border of the mandible can be classified into a three point scale according to MCI, C1: the cortex is sharp on both sides; C2: the cortex had semilunar defects(lacunar resorption) and c3: cortex is clearly porous | Five months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mental index(MI) | The quantitative index that used for cortical width measurement at the mental foramen region | Five months | 
| Panoramic mandibular index(PMI) | Measure the mandibular cortical thickness in relation to the distance between the mental foramen and the inferior border of mandible | Fivemonths | 
| Anti-gonial index(AI) | A quantitative index measure the cortical width in the region that is anterior to the gonion | Five months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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CBCT, Bone quality, Renal failure