Pilot Trial Comparing Computerised Cognitive Exercises to Tetris in Adolescents With ADHD

Study Overview
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Brief Summary
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The purpose of this study was to examine the feasibility and efficacy of computerized cognitive exercises from Scientific Brain Training (SBT), compared to the computer game Tetris as an active placebo, in a pilot study of adolescents with Attention-deficit/hyperactivity disorder (ADHD).

Detailed Description
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Objective: To examine the feasibility and efficacy of computerized cognitive exercises from Scientific Brain Training (SBT), compared to the computer game Tetris as an active placebo, in a pilot study of adolescents with Attention-deficit/hyperactivity disorder (ADHD). Method: Eighteen adolescents with ADHD were randomized to treatment or control intervention for seven weeks. Outcome measures were cognitive test, symptom and motivation questionnaires.

Official Title
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A Double-Blind Randomized Pilot Trial Comparing Computerised Cognitive Exercises to Tetris in Adolescents With Attention-Deficit/Hyperactivity Disorder

Conditions
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Attention Deficit/Hyperactivity Disorder

Intervention / Treatment
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* Other: Scientific Brain Training (SBT)
* Other: Tetris


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: a clinical diagnosis of hyperkinetic disorder (F90.0, corresponding to ADHD combined type) (WHO, 1993); age between 14-17 years; IQ > 80. Exclusion Criteria: pharmacological treatment other than methylphenidate, dexamphetamine and/or atomoxetine; comorbid conduct disorder, autism spectrum disorders or major depression; history of head trauma or verified neurological disease; motor or perceptual disabilities which prevented the use of a computer; medical illness that required treatment; no access to a computer and internet at home.

Ages Eligible for Study
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Minimum Age: 14 Years
Maximum Age: 17 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention<br>Scientific Brain Training (SBT) | Other: Scientific Brain Training (SBT)<br>* Cognitive training<br>|
| Placebo Comparator: Controle<br>Tetris | Other: Tetris<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Activity Perception Questionnaire |  | 7 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Attention Deficit/Hyperactivity Disorder-Rating Scale |  | 7 weeks | 
| Cambridge Neuropsychological Test Automated Battery (CANTAB) Rapid Visual Information Processing (RVP)(A) |  | 7 weeks | 
| CANTAB: Stockings of Cambridge (SOC) (problems solved in minimum moves) |  | 7 weeks | 
| CANTAB: DMS Delayed Matching to Sample (DMS) |  | 7 weeks |