Impact of Sarcopenia on Postoperative Outcomes of Patients Undergoing Liver Resection

Study Overview
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Brief Summary
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The investigators will investigate the impact of different biometric parameters (Body mass index, sarcopenia, lean muscle mass, hand-grip strength, gait speed, fat composition) on the postoperative outcomes of patients undergoing liver resections. Major and minor liver resections will be considered as well as open and minimally invasive techniques. Benign and malignant indications will be included. Patients characteristics and perioperative variables will be considered for analysis. Short-term outcomes will be evaluated focusing on 90-days morbidity and mortality and readmission rate.

Detailed Description
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According to the null hypothesis, no difference in postoperative morbidity between the two groups would be expected. To calculate sample size, a 42% morbidity rate would be expected in sarcopenic patients while a 22% rate would be expected in the non-sarcopenic group. Considering a two-sided α=0.05 and β=0.1, the minimal sample size required to achieve statistical significance was 224 subjects. Considering a 10% drop-out rate of patients undergoing explorative laparoscopy or laparotomy without parenchymal resection a total of 249 patients will be required for completion of the study

Official Title
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The Impact of Sarcopenia, Body Composition and Other Biometric Parameters on the Postoperative Outcomes of Patients Undergoing Liver Resection for Different Indications

Conditions
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Liver Neoplasms, Sarcopenia, Postoperative Complications

Intervention / Treatment
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* Procedure: Liver resection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients undergoing open or laparoscopic liver resection Patients undergoing major or minor liver resection Patients undergoing liver resection for primary or secondary liver malignancies Patients undergoing liver resections for benign diseases (cysts, adenoma, focal nodular hyperplasia, hemangioma) - Exclusion Criteria: Patients undergoing extrahepatic resection Patients undergoing cyst fenestration or biopsies without liver resections Patients with extrahepatic metastases Patients undergoing explorative laparoscopy or laparotomy without parenchymal transection -

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Liver resection<br> | Procedure: Liver resection<br>* Major or minor, open or laparoscopic liver resection<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Morbidity | Patients experiencing medical or surgical complications after surgery | within 90 days after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | Patients dying after surgery | within 90 days after surgery | 
| Readmission rate | patients readmitted to hospital after discharge | within 90 days after discharge | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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sarcopenia, hepatocellular carcinoma, colorectal liver metastases, non-colorectal liver metastases, focal nodular hyperplasia, liver hemangioma, liver cysts, surgical morbidity, surgical mortality