Association of Midlife Dietary and Lifestyle Factors on Cardiac Functional Changes in the Elderly

Study Overview
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Brief Summary
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The investigators aim to investigate the association of midlife dietary and lifestyle factors on cardiac functional changes in the elderly. The investigators hypothesize that even in those without clinically manifest cardiovascular disease, the extent of underlying abnormalities in cardiovascular structure and function in the elderly would be independently related to midlife dietary and lifestyle factors.

Detailed Description
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This proposal will investigate how midlife factors in diet and lifestyle affect various aspects of cardiac structure and function related to ageing. The investigators plan to conduct the study among a sub-cohort of 600 participants from the Singapore Chinese Health Study. Comprehensive information on diet and lifestyle factors had been collected at recruitment and updated in two subsequent follow-up interviews. Candidate nutrition-related blood biomarkers such as vitamins D, homocysteine, fatty acids (short, medium and long-chain) and lipids (LDL, HDL, triglycerides) will be analyzed from samples obtained between 1999 and 2004. The investigators will study effects of smoking, alcohol consumption, sleep duration, physical activity and diet on cardiac ageing. The investigators will study overall dietary pattern, intake of specific items such as fatty acids, soy food, coffee and tea beverages, from validated food frequency questionnaires (FFQ), and nutrients from questionnaire information from this cohort previously obtained. These nutrient and lifestyle factors will be studied individually, and for their joint or interactive effects on cardiac ageing measurements. Quantitative cardiac ageing-related outcome parameters describing cardiac mass, systolic and diastolic function, and vessel distensibility will be examined by cardiac magnetic resonance imaging. Maximum oxygen uptake (VO2 max) will be calculated based on age, gender, waist circumference, resting heart rate, and exercise habits. Body composition will be analysed by a body composition analyser machine onto which subjects stand on.

Official Title
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Association of Midlife Dietary and Lifestyle Factors on Cardiac Functional Changes in the Elderly

Conditions
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Ageing

Intervention / Treatment
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* Other: Cardiovascular Magnetic Resonance Imaging (MRI)
* Other: Echocardiography
* Other: Tonometry
* Other: Genetic Testing (Blood)
* Other: Hand-Grip Strength Measurement
* Other: Body Fat Mass Analysis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Who were younger than 60 years at recruitment Had been interviewed at baseline and at the two follow-up interviews Had provided biospecimens for research previously before the age of 65 years (2000-2004) Who will be 65 years or older by 2013 Exclusion Criteria: Any known history of heart disease or stroke Anticipated life expectancy < 1 year Unable to provide written informed consent to participate in the study Patients with cancer Patients with chronic renal disease Any metallic implants

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control<br>Healthy Volunteers will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI) Echocardiography Tonometry Genetic Testing (Blood) Hand-Grip Strength Measurement Body Fat Mass Analysis | Other: Cardiovascular Magnetic Resonance Imaging (MRI)<br>* Cardiovascular MRI uses interaction of the magnetic properties of body tissues with strong magnetic fields to create heart images.<br>Other: Echocardiography<br>* To measure heart chamber size, heart function, blood vessel size and blood vessel function. These measurements will help us understand the type and severity of heart failure.<br>Other: Tonometry<br>* Tonometry is a noninvasive method to obtain arterial pressure waveform<br>Other: Genetic Testing (Blood)<br>* The blood will be stored for genetic tests and development of cell lines to study genetic risks for aging related diseases and cardiovascular disease.<br>Other: Hand-Grip Strength Measurement<br>* We will measure your hand grip strength using a standard hand dynamometer which is a portable meter that you will use your hands to press on.<br>Other: Body Fat Mass Analysis<br>* Body composition will be analysed by a body composition analyser machine onto which you will have to stand on.<br>|
| Ageing<br>Ageing cohort will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI) Echocardiography Tonometry Genetic Testing (Blood) Body Fat Mass Analysis | Other: Cardiovascular Magnetic Resonance Imaging (MRI)<br>* Cardiovascular MRI uses interaction of the magnetic properties of body tissues with strong magnetic fields to create heart images.<br>Other: Echocardiography<br>* To measure heart chamber size, heart function, blood vessel size and blood vessel function. These measurements will help us understand the type and severity of heart failure.<br>Other: Tonometry<br>* Tonometry is a noninvasive method to obtain arterial pressure waveform<br>Other: Genetic Testing (Blood)<br>* The blood will be stored for genetic tests and development of cell lines to study genetic risks for aging related diseases and cardiovascular disease.<br>Other: Body Fat Mass Analysis<br>* Body composition will be analysed by a body composition analyser machine onto which you will have to stand on.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| First occurrence of cardiovascular event |  | 1 Year |