The Effect of Nandrolone Decanoate and Leucine on Muscle Loss

Study Overview
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Brief Summary
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A decrease in muscle mass can have a profound impact on quality of life, as it can lead to decreased strength, insulin resistance, lower basal metabolic rate and obesity. With this study we investigate whether ingesting leucine or getting a ND injection will reduce the loss of muscle mass and strength.

Official Title
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The Effect of Nandrolone Decanoate Injection and Leucine Supplementation on Muscle Loss

Conditions
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Muscle Atrophy

Intervention / Treatment
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* Behavioral: Inactivity
* Drug: ND
* Dietary Supplement: Leu


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy men 18-35 years BMI between 18.5 and 30 kg/m2 Exclusion Criteria: - (Family) history of thromboembolic events Smoking Recent surgery (within 6 months prior to the study) Performing progressive resistance training more than three times per week in the past year Any back/leg/knee/shoulder complaints which may interfere with the use of crutches Current systemic use of corticosteroids, anabolic steroids, growth hormone, testosterone, nandrolone, protein supplements, immunosuppressants or insulin, blood sugar decreasing medication or EPO All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis) Use of anti-coagulants Pre-existing renal disease or those with a potential risk for renal dysfunction (diabetes, hypertension, reduced glomerular filtration rate) Liver disease Heart failure Migraine Allergy to nuts or soy High blood pressure (>140 mmHg systolic and >90 mmHg diastolic) In case of doubt, in- or exclusion of subject will be discussed with responsible physician or principal investigator.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Leu during inactivity<br>Leucine supplements | Behavioral: Inactivity<br>* Inactivity<br>Dietary Supplement: Leu<br>* Leucine supplements<br>* Other names: Leucine;|
| Experimental: ND during inactivity<br>Nandrolone injection | Behavioral: Inactivity<br>* Inactivity<br>Drug: ND<br>* 1 nandrolone decanoate injection<br>* Other names: Nandrolone;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CSA Quadriceps (CT scan) | CT scan | 7 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle strength as measured by 1RM test |  | 7 days | 
| Muscle fiber type and CSA as measured by histochemistry from the muscle biopsy |  | 7 days |