Comparison of Two Mechanical Ventilation Modes on Oxygenisation

Study Overview
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Brief Summary
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Comparison the effect of two different mechanical ventilation modes on tissue oxygenization.

Detailed Description
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Aim of the study is to evaluate and compare the effects of two different mechanical ventilation modes as Volume Controlled Mechanical Ventilation (VCV) and Pressure Controlled Mechanical Ventilation (PCV) on non invasive tissue oxygenization levels of patients who scheduled for bariatric surgery.

Official Title
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Comparison of Two Mechanical Ventilation Strategies on Tissue Oxygenization of Patients Undergoing Bariatric Surgery

Conditions
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Bariatric Surgery Candidate, Mechanical Ventilation, Hypoxia, Tissue Damage

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with Body Mass Index 35 - 50 kg/m2 Patients classified as American Society of Anesthesiologist (ASA) 1-2-3 classification Patients elected for Bariatric surgery Exclusion Criteria: Patients who wants to reject of study participation Patients who has any surgical complication during the surgery period Patients with decompensated cardiac failure Patients with Moderate or Severe obstructive/restrictive lung disease Patients with Reynaud disease Patients with Buerger phenomena Patients whıo has Intraoperative airway pressure more than 45 cmH2O Patients who had previous thoracic surgery Patients with Negative Modified Allen test

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Oxygenization | Peroperative Non invazive technique of Superficial Tissue Oxygenization | peroperative 0. minute - 15. minute - 30. minute - 45. minute - 60. minute | 
| Oxygenization-2 | Post operative Non invazive technique of Superficial Tissue Oxygenization | post operative 1. hour - 4. hour - 8. hour - 12. hour - 24.hour | 
| Arterial blood gas analysis | Lactate, Ph, Arterial oxygen pressure, Arterial Carbondioxide pressure, Oxygen Saturation | Peroperative 0. minute - 30. minute - 60. minute | 
| Arterial blood gas analysis-2 | Lactate, Ph, Arterial oxygen pressure, Arterial Carbondioxide pressure, Oxygen Saturation | post operative 1.hour - 4. hour - 8. hour - 12. hour - 24.hour | 
| Peripheral oxygen saturation | Peripheral Oxygen Saturation (SpO2) | peroperative 0. minute - 15. minute - 30. minute - 45. minute - 60. minute | 
| Peripheral oxygen saturation-2 | Peripheral Oxygen Saturation (SpO2) | post operative 1.hour - 4. hour - 8. hour - 12. hour - 24.hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Peroperative hemodynamic measurements | Heart rate, Mean Arterial Blood Pressure | peroperative 0. minute - 15. minute - 30. minute - 45. minute - 60. minute | 
| Postoperative hemodynamic measurements | Heart rate, Mean Arterial Blood Pressure | post operative 1.hour - 4. hour - 8. hour - 12. hour - 24.hour | 
| Carbondioxide | End tidal Carbondioxide measurement | peroperative 15. minute - 30. minute - 45. minute - 60. minute | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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bariatric surgery, tissue oxygenization, ventilation