Clinical Evaluation of Injectable Platelet Rich Fibrin With Connective Tissue Graft for the Treatment of Deep Gingival Recession Defects.

Study Overview
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Brief Summary
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Aim: The aim of this study was to determine whether the combined connective tissue graft (CTG) with injectable platelet rich fibrin (i-prf) with coronally advanced flap (CAF) improved root coverage of deep Miller Class I or II gingival recessions compared to CTG alone with CAF. Methods: Seventy-two patients with Miller class I and II gingival recessions were enrolled. Thirty-six patients were randomly assigned to the test group (CAF+CTG+i-prf) or control group (CAF+CTG). Clinical evaluations were made at 6 months

Official Title
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Clinical Evaluation of Injectable Platelet Rich Fibrin With Connective Tissue Graft for the Treatment of Deep Gingival Recession Defects. A Controlled Randomized Clinical Trial.

Conditions
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Gingival Recession

Intervention / Treatment
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* Procedure: CAF+CTG+i-prf


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ≥19 years of age, Periodontally and systemically healthy, FMPS and FMBS <15%, Presence of deep Miller class I and II gingival recession defect (≥3 mm in depth) at the buccal aspect of incisors, Exclusion Criteria: Smoking, Contraindications for surgery, Presence of recession defects associated with caries, deep abrasion, restoration or pulpal pathology.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: CAF+CTG<br>the combined connective tissue graft (CTG) with coronally advanced flap (CAF) | Procedure: CAF+CTG+i-prf<br>* combined connective tissue graft (CTG) and injectable platelet rich fibrin (i-prf) with coronally advanced flap (CAF)<br>|
| Experimental: CAF+CTG+i-prf<br>the combined connective tissue graft (CTG) and injectable platelet rich fibrin (i-prf) with coronally advanced flap (CAF) | Procedure: CAF+CTG+i-prf<br>* combined connective tissue graft (CTG) and injectable platelet rich fibrin (i-prf) with coronally advanced flap (CAF)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| gingival recession depth | the distance between the CEJ and gingival margin-measurements were performed at the midbuccal aspect of the teeth, by manual probe and were rounded up to the nearest millimetre | six months | 
| Keratized tissue height | measured from the mucogingival junction to the gingival margin-measurements were performed at the midbuccal aspect of the teeth, by manual probe and were rounded up to the nearest millimetre | six months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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connective tissue graft