Effect of Domperidone on Completion Rate of Vedio Capsule Endoscopy

Study Overview
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Brief Summary
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Video capsule endoscopy (VCE) has become an established technique to investigate the presence of small bowel pathology. But the limited battery life of capsules can lead to incomplete small bowel visualization. There is a rationale to use prokinetic agents prior to VCE reduce the chances of an incomplete small bowel examination via decrease gastric transit time (GTT). Investigators are aimed to prospectively compare the completion rate of VCE in pediatric patients receiving prokinetic with those receiving no prokinetic.

Detailed Description
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Eligible children were randomly divided into two groups: domperidone prior to VCE and water prior to VCE. The primary outcome measure was the completion rate. Secondary outcome measures included the GTT and SBTT.

Official Title
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Effect of Domperidone on Completion Rate of Vedio Capsule Endoscopy: a Prospective Randomized Controlled Study

Conditions
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Capsule Endoscopy, Pediatric Disorder

Intervention / Treatment
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* Drug: Domperidone
* Dietary Supplement: water


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Indications of capsule endoscopy; Informed consent form obtained. Exclusion Criteria: Contraindication of capsule endoscopy; Domperidone allergy; Unwilling to participate.

Ages Eligible for Study
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Minimum Age: 3 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Experimental: Domperidone<br>5ml domperidone prior to VCE | Drug: Domperidone<br>* 5ml Domperidone prior to VCE<br>* Other names: simethicone;|
| Other: Control: water<br>5ml warm water prior to VCE | Dietary Supplement: water<br>* 5ml water prior to VCE<br>* Other names: simethicone;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Completion rate of capsule endoscopy | CE was considered complete when the cecum was reached within recording time. | assessed through study completion, an average of 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gastric transit time (GTT) | The GTT was defined as the time, in minutes, from the first image of the stomach until the first image of the duodenum. | assessed through study completion, an average of 1 year | 
| small bowel transit time (SBTT) | The SBTT was defined as the passage time, in minutes, from the first image of the duodenum until the first image of the cecum. | assessed through study completion, an average of 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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domperidone