Impact of Vitamin D Level and Supplement on SLE Patients During COVID-19 Pandemic

Study Overview
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Brief Summary
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Aim of the work Impact of serum vit D level in SLE patients with COVID-19 disease on severity of infection, duration of COVID-19 disease course, fatigue development as a complication for both SLE and COVID-19 and assess impact of prior chloroquine on COVID-19 disease outcomes Patients and methods 38 SLE patients previously diagnosed and on different lines of lupus management. Participants were presented to chest outpatient clinic and emergency hospital, Mansoura University with manifestation suggesting COVID-19 infection. Serum vit D was measured in serum by ELISA.

Detailed Description
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Primary objective: assess the impact of serum vit D level in SLE patients with COVID-19 disease on severity of infection and pandemic treatment outcome. Secondary objectives: Effect of serum vit D level in SLE patients on duration of COVID-19 disease course and fatigue development as a complication for both SLE and COVID-19 Impact of prior chloroquine on COVID-19 disease outcomes Correlation of serum vit D level with different laboratory investigations at time of COVID-19 outbreak

Official Title
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Impact of Vitamin D Level and Supplement on SLE Patients During COVID-19 Pandemic

Conditions
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Covid19

Intervention / Treatment
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* Drug: Vitamin D
* Diagnostic Test: ELISA


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - SLE patients previously diagnosed Patients are not suffering from malignancies. Patients have no organ failure nor uncontrolled medical illness. Recent COVID-19 infection Exclusion Criteria: - Pregnant, lactating females Concurrent malignancies Patients with other autoimmune disease

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| SLE patients<br>SLE patients were presented to chest outpatient clinic and emergency hospital, Mansoura University with manifestation suggesting COVID-19 infection. Vit D was measured in serum by ELISA. Vit D was added to anti COVID-19. | Drug: Vitamin D<br>* Impact of serum vit D level in SLE patients with COVID-19 disease on severity of infection, duration of COVID-19 disease course, fatigue development as a complication for both SLE and COVID-19 and assess impact of prior chloroquine on COVID-19 disease outcomes<br>* Other names: Serum Vitamin D level;Diagnostic Test: ELISA<br>* Measure vitamin D level<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Level of serum vitamin D in SLE infected with COVID-19 | Measurement of serum vit D level (ng/ml) | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vitamin D level with COVID-19 severity | Level of serum vitamin D (ng/ml) in mild, moderate and sever COVID-19 | 6 months |