Tissue Sample Collection From Patients With Fanconi Anemia

Study Overview
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Brief Summary
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RATIONALE: Collecting and storing samples of tumor tissue from patients with Fanconi anemia to test in the laboratory may help the study of cancer in the future. PURPOSE: This laboratory study is collecting and storing tumor tissue samples from patients with Fanconi anemia.

Detailed Description
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OBJECTIVES: Acquire rare solid tumor samples from patients with Fanconi anemia in order to create a Fanconi Anemia Cell Repository at the Oregon Health and Science University Cancer Institute. Study repository tissue using a variety of molecular methods, including gene microarrays. Develop cancer cell lines that are publicly available from tissue archived from patients with Fanconi anemia. OUTLINE: Tumor biopsies are collected from patients with Fanconi anemia and archived for future molecular studies, cell line generation, and general usage by the research community at large. Medical information about the patient's cancer is also archived. PROJECTED ACCRUAL: Not specified.

Official Title
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Fanconi Anemia Cancer Cell Repository

Conditions
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Fanconi Anemia, Unspecified Adult Solid Tumor, Protocol Specific, Unspecified Childhood Solid Tumor, Protocol Specific

Intervention / Treatment
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* Other: biologic sample preservation procedure
* Procedure: biopsy


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Confirmed Fanconi anemia Confirmed malignant solid tumor Biopsy of tumor tissue available PATIENT CHARACTERISTICS: Not specified PRIOR CONCURRENT THERAPY: Not specified

Ages Eligible for Study
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Minimum Age: 1 Year
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: biologic sample preservation procedure|Once the pathologist has taken the material needed to establish diagnosis of cancer, the anonymized snap-frozen and fresh samples will be either shipped to our laboratory for analysis or will be picked up by a member of the principal investigator's lab team. Samples will be stored indefinitely.|
|Procedure: biopsy|Once the pathologist has taken the material needed to establish diagnosis of cancer, 1-10 grams of the remaining tissue should be placed in phosphate buffered saline and shipped to the Bagby Lab.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Creation of a Fanconi Anemia Cell Repository using rare solid tumor samples from patients with Fanconi anemia |  | Duration of the study | 
| Study tissue samples by molecular methods, including gene microarrays |  | Duration of the study | 
| Development of cancer cell lines from tissue archived from patients with Fanconi anemia |  | Duration of the study | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Fanconi anemia, unspecified adult solid tumor, protocol specific, unspecified childhood solid tumor, protocol specific