Ovarian Reserve in Patients With Psoriasis

Study Overview
=================
Brief Summary
-----------------
Psoriasis is a common autoimmune disease. It affects women of all ages including reproductive years. Autoimmune diseases including psoriasis are linked to premature ovarian reserve. This study aims to measure serum hormones including FSH,LH,E2,PRL and AMH (indicators of ovarian reserve) in women with and without psoriasis.

Detailed Description
-----------------
Psoriasis is a common autoimmune disease. It affects women of all ages including reproductive years. Almost 75% of patients are diagnosed before the age of 40. There is also increased evidence on autoimmune disease and their link to premature ovarian failure.Ovarian reserve is important for the reproductive period. The measurements of serum hormones including follicle stimulating hormone (FSH),luteinizing hormone (LH),prolactin (PRL), estradiol (E2) and anti-mullerian hormone (AMH) will give us an idea about the ovarian reserve. The investigators aim is to measure ovarian reserve parameters in patients newly diagnosed with psoriasis and to compare them to healthy controls. Serum FSH,LH,E2,PRL and AMH will be measured on the 3rd day of the cycle.The serum hormone levels will be compared between women with psoriasis and women without psoriasis

Official Title
-----------------
Ovarian Reserve in Patients With Psoriasis

Conditions
-----------------
Psoriasis, Anti Mullerian Hormone, Ovarian Reserve

Intervention / Treatment
-----------------
* Other: Hormone panel


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Reproductive age group women: 18-40 years Women diagnosed with psoriasis (case group) Women without psoriasis (control group) Exclusion Criteria: Women with PCOS (polycystic ovary syndrome) history of ovarian surgery Body mass index (BMI) over 30 Women with other autoimmune diseases including Hashitomo thyroiditis Women with family history of premature ovarian insufficiency (POI) Women with infertility Psoriasis using systemic drugs including steroids and immunosuppressive therapy.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Women with Psoriasis<br>Reproductive age women newly diagnosed with psoriasis | Other: Hormone panel<br>* Blood sampling on the 3rd day of menstrual cycle for the measurement of serum FSH,LH,PRL,E2 and AMH hormone levels.<br>|
| Women without Psoriasis<br>Reproductive age women without psoriasis to serve as control | Other: Hormone panel<br>* Blood sampling on the 3rd day of menstrual cycle for the measurement of serum FSH,LH,PRL,E2 and AMH hormone levels.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| to compare serum AMH levels between the two groups | Serum AMH levels will be measured (using ELISA) and compared between the two groups | 1 day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
psoriasis, Anti mullerian hormone, ovarian reserve, antral follicle count