Development and Validity of the DyNaChron Questionnaire for Chronic Nasal Dysfunction

Study Overview
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Brief Summary
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Nasal symptoms are the main elements that lead to a therapeutic decision and allow for evaluating treatment effects or natural evolution. Despite availability of several questionnaires with good measurement qualities, no systematic assessment takes into account the specific physical and psychosocial consequences of each of the six main nasal symptoms, independently of the disease. The study proposed to measure these symptoms with the use of a selfreport questionnaire and to test the validity of the questionnaire in a large representative sample of patients attending outpatient rhinologic clinics.

Detailed Description
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The study was conducted in two parts: (1) expert-based development and testing of the face validity of a questionnaire in French; and (2) validity testing, including construct validity by factor analysis, reproducibility by intraclass correlation coefficient (ICC) and Bland and Altman plots, and sensitivity to change by standardized response means, on a large sample of patients in a prospective multicenter study. DyNaChron, a questionnaire with 78 items divided into six domains and exploring both the physical and psychosocial repercussions of CND, was developed. In total, 759 patients completed the questionnaire at a first visit to a clinic, and 539 again 19.5 days later, on average.

Official Title
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Development and Validity of the DyNaChron Questionnaire for Chronic Nasal Dysfunction

Conditions
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Rhinitis, Nasal Polyps

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria:Patients had to be older than 18 years have nasal or sinus dysfunction for more than 3 months be able to understand and read theFrench language. Exclusion Criteria: nasal or sinus tumor or Rendu-Osler disease, patients were under immediate post-operative care

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Development of the DyNaChron questionnaire for chronic nasal dysfunction | to develop a self-report questionnaire to assess nose and sinus functional symptoms together with their consequences for physical and psychosocial areas | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Validation of the DyNaChron questionnaire for chronic nasal dysfunction | to test the validity of the new instrument developped in a large representative sample of patients attending outpatient rhinology clinics | 10 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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chronic nasal dysfunction, Quality of life, measurement, self-reporting questionnaire, development, validation