linjc16/ctgov huggingface dataset:
Sickle Cell Disease: A Retrospective Chart Review

Study Overview
=================
Brief Summary
-----------------
This study is a retrospective chart review of sickle cell patients and will include patients whom have received blood transfusions and those whom have not. Of the transfused patients, it will also include those whom have received chelation therapy and those whom have not.

Official Title
-----------------
Complications in Patients With Sickle Cell Disease and Utilization of Iron Chelation Therapy: A Retrospective Medical Records Review

Conditions
-----------------
Sickle Cell Anemia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with a diagnosis of Sickle Cell Disease (SCD) and a confirmed genotype Patients ≥ 16 years of age Patients with ≥ 6 months of follow-up data available from first SCD treatment at the center after they reach 16 years old At least one SF reading during a non-acute phase on or after the first SCD treatment at the center after they reach 16 years old Exclusion Criteria: Patients who participated in a clinical trial for an iron chelating medication or in a clinical trial for transfusions for SCD (1) within the six months before the index date or (2) during the patient observation period Patients with sickle cell trait Other protocol-defined inclusion/exclusion criteria may apply

Ages Eligible for Study
-----------------
Minimum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sickle cell patients non-transfused<br> | |
| Sickle cell patients transfused with no ICT<br> | |
| Sickle cell patients transfused with ICT<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sickle cell complications |  | average of 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Utilization of health care delivery to treat sickle cell complications |  | average of 5 years | 
| Overall survival |  | average of 5 years | 
| Utilization of blood transfusions (patients with frequent transfusions only) |  | average of 5 years | 
| Burden of iron overload (patients with frequent transfusions only) |  | average of 5 years | 
| Utilization of Iron Chelation Therapies (ICTs) (patients receiving deferoxamine or deferasirox [Exjade®] only) |  | average of 5 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Sickle cell anemia
TARGet Kids!: Measuring Nutrition in Young Preschool Children in the Primary Care Practice Setting

Study Overview
=================
Brief Summary
-----------------
TARGet Kids! (The Applied Research Group for Kids) is a research study enrolling healthy children aged 0-5 years. The aim of the TARGet Kids! registry is to link early life exposures to health problems including obesity, micronutrient deficiencies, and developmental problems. TARGet Kids! represents an innovative collaboration between child health researchers and children's primary care doctors (pediatricians and family physicians) to promote research that really matters and create solutions to some of the today's biggest health concerns. The results of this collaborative research study are not only improving the quality of children's healthcare but also the health of children across the country. Coordinated by Sick Kids and St. Michael's Hospital with data management services by the Applied Health Research Centre (AHRC), TARGet Kids! is the only primary care research network for children in Canada.

Official Title
-----------------
TARGet Kids!: Measuring Nutrition in Young Preschool Children in the Primary Care Practice Setting

Conditions
-----------------
Nutritional Disorders, Obesity, Development

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Birth to less than 6 years of age Parental consent Attending a TARGet Kids! research network practice Exclusion Criteria: Chronic illness with the exception of asthma

Ages Eligible for Study
-----------------
Maximum Age: 5 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy children<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body Mass Index (BMI) | Change in BMI over a 10 year follow-up period | 10 years (yearly measurements) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nutrition | Nutritional risk | Yearly measurements | 
| Development | Child development | Yearly measurements | 
| Mental Health | Mental Health | Yearly measurements | 
| Lifestyle Factors | Assessment of Lifestyle Factors that contribute to health | Yearly measurements | 
| Child Behavior | Child behavior | Yearly measurements | 
| Social Determinants | Social determinants of health | Yearly measurements | 
| Education | Nutritional factors affects on education | Yearly measurements | 
| Parenting | Parenting styles | Yearly measurements |
Effectiveness of Internet-based Depression Treatment

Study Overview
=================
Brief Summary
-----------------
Care for people suffering from depressive symptoms should be given in a step-wise approach. One first step can be the provision of self-help material. Online self-help is an innovative way of providing self-help. The investigators want to study the effect of an interactive online self-help-program (Deprexis) in the treatment of mild to moderate depressive symptoms. Participants will be randomised to either twelve weeks of online-self help or a waiting-list control. Symptoms of depression and other aspects will be assessed over a one year period. Thereafter the controls will also receive online-self help. The investigators hypothesise that online self-help is superior to the control condition in alleviating depressive symptoms and preventing full blown depression.

Detailed Description
-----------------
This study is supported by the German Ministry of Health (BMG) and is a collaborative project of Universität Bern (PD Dr. Thomas Berger), Charité Berlin (PD Dr. Matthias Rose), Universität Bielefeld (Prof. Dr. Wolfgang Greiner), Universität Hamburg (Prof. Dr. Steffen Moritz, Prof. Dr. Bernd Löwe), GAIA AG Hamburg (Dr. Björn Meyer), Universität Tübingen (Prof. Dr. Martin Hautzinger) and Universität Trier (Prof. Dr. Wolfgang Lutz).

Conditions
-----------------
Mild to Moderate Depressive Symptoms

Intervention / Treatment
-----------------
* Behavioral: Deprexis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: PHQ>4 and <15 Exclusion Criteria: acute suicidality psychotic d/o, bipolar d/o or other severe psychiatric d/o

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Deprexis<br>Online self-help with and without e-mail-support | Behavioral: Deprexis<br>* Online self-help with and without e-mail-support<br>|
| No Intervention: Control<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Personal Health Questionnaire (PHQ-9) |  | 12 wks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hamilton Rating Scale for Depression (HRSD) |  | 12 wks, 6 mths, 12 mths | 
| Quick Inventory of Depressive Symptoms (QIDS) |  | 12 wks, 6 mths, 12 mths | 
| Personal Health Questionnaire (PHQ-9) |  | 6 mths, 12 mths |
Treatment Options for Pediatric Chronic Pain: How do we Best Disseminate Our Scientific Findings

Study Overview
=================
Brief Summary
-----------------
Pediatric chronic pain is a prevalent condition with manifold treatment options. However, knowledge of targeted dissemination of intervention research findings is currently lacking. The aim of this project is to determine satisfaction with current knowledge transfer from science to clinical practice amongst health care professionals, adolescents with CPP and their parents and to understand what treatment options have been offered to patients in Swiss pain centers Three focus groups, one with health care professionals, one with adolescent patients, and one with their parents, will be conducted to determine how the dissemination of scientific evidence to clinical practice can be improved and what hurdles exists when gathering information about pain interventions. In addition, patients will be asked about the treatment options offered to them and health care professionals about which treatments they routinely prescribe and why.

Official Title
-----------------
Dissemination of Scientific Findings: Wishes and Realities in the Field of Pediatric Chronic Pain

Conditions
-----------------
Pediatric Chronic Pain

Intervention / Treatment
-----------------
* Other: No intervention, observational study


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adolescent group: Adolescents suffering from chronic pain (i.e., persistent or recurrent pain for three months or more) Able to read and speak German Parent group: Parents of an adolescent with chronic pain Able to read and speak German Health care professionals group: Health care professional working with adolescents with chronic pain Able to read and speak German Exclusion Criteria: no chronic pain or experience with chronic pain

Ages Eligible for Study
-----------------
Minimum Age: 13 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Adolescents with chronic pain<br> | Other: No intervention, observational study<br>* Focus Group<br>|
| Parents of adolescents with chronic pain<br> | Other: No intervention, observational study<br>* Focus Group<br>|
| Health care professionals who work with adolescents with chronic pain<br> | Other: No intervention, observational study<br>* Focus Group<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Information seeking behavior | Participants' key messages will be reduced to major subjects by means of content analysis. The goal is to understand participants' information seeking behavior with regard to chronic pain and interventions for chronic pain | immediattely after the focus group |
Effects of Watermelon Consumption on Satiety and Digestive Health

Study Overview
=================
Brief Summary
-----------------
The objective of the proposed research is to determine the effects of watermelon (fruit and rind blenderized) on satiety, metabolic markers, bowel habits, microbiome and weight management in children and adults

Official Title
-----------------
Effects of Watermelon Consumption on Satiety and Digestive Health

Conditions
-----------------
Satiety

Intervention / Treatment
-----------------
* Other: Red juice
* Other: Watermelon juice


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Generally healthy subjects Exclusion Criteria: Smoker Pregnant woman Required dietary supplement use Required medication of metabolic disorders Allergy to watermelon

Ages Eligible for Study
-----------------
Minimum Age: 10 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Red juice<br>Subjects consume 8 fl oz of red juice daily for 8 weeks | Other: Red juice<br>* To determine the effects of red juice on satiety and gut health<br>|
| Experimental: Watermelon juice<br>Subjects consume 8 fl oz of watermelon juice daily for 8 weeks | Other: Watermelon juice<br>* To determine the effects of watermelon juice on satiety and gut health<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of satiety | Change of hunger feeling (appetite) will be examined using visual analog scale (0-10), 0 least and 10 greatest | 0 and 20, 40, 60, 90 and 120 minutes post juice consumption | 
| Change of glucose level | Change of blood glucose level will be determined to examine effects of watermelon juice consumption vs red juice | 0 and 20, 40, 60, 90 and 120 minutes post juice consumption | 
| Change of insulin level | Change of blood insulin level will be determined to examine effects of watermelon juice consumption vs red juice | 0 and 20, 40, 60, 90 and 120 minutes post juice consumption | 
| Change of triglyceride level | Change of triglyceride level with watermelon juice consumption vs red juice consumption | Baseline and week 8 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of alpha diversity in microbiome | Change of alpha diversity in micriobiome with watermelon juice consumption vs red juice consumption | Baseline and week 8 |
Instrument Applied and Manual Manipulation Induced EMG Response in Asymptomatic Subjects

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine the affects of instrumental and manual manipulation on the EMG response of asymptomatic subjects.

Conditions
-----------------
EMG Response

Intervention / Treatment
-----------------
* Device: ProAdjuster


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Asymptomatic subjects (without somatosensory peripheral pain) will be recruited in the study. Subjects must sign an informed consent. Exclusion Criteria: Subjects with heart failure and any nervous system diseases will be excluded from the study. Additional exclusions include osteoporosis, diabetes, pregnancy, vascular insufficiency, and history of joint replacement therapy. Subjects under medical treatment, surgery and trauma within six months will be excluded.

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: ProAdjuster|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Outcome After Selective Dorsal Rhizothomy Concerning Life Quality, Cerebral Imaging and Cognition

Study Overview
=================
Brief Summary
-----------------
Selektive dorsal rhizotomy (SDR) has been used as treatment option in children suffering from cerebral palsy (CP) for several decades and multiple studies demonstrated its benefits. Nevertheless, there are still no proven strategies for patient selection, optimal point of time for the operation or pre- and postoperative therapies. The evaluation of the impact of selective motor control, cognition and cerebral imaging findings on the motor outcome and life quality in children with CP who underwent SDR at the Charité University clinics will clarify these critical points in daily care for patients with CP.

Detailed Description
-----------------
SDR at the Charité University clinics. Two study visits before surgery and during the follow-up 3 months, 6 months, 12 months, 24 months and 5 years post-operatively.

Official Title
-----------------
SDR-Auswertung, Unterteil Kognition, Bildgebung, Lebensqualität

Conditions
-----------------
Cerebral Palsy, Spastic

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: clinical diagnosis of cerebral palsy able to perform most tasks according to study protocols parents and physician decided to perform SDR Exclusion Criteria: not able to perform any tasks according to study protocols no candidate for SDR

Ages Eligible for Study
-----------------
Minimum Age: 2 Years
Maximum Age: 25 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Motor function measured by GMFCS | Ability of a child to perform specified motor tasks, measured by GMFCS and GMFM-88 | 5 years | 
| Motor function measured by GMFM-88 | Ability of a child to perform specified motor tasks, measured by GMFCS and GMFM-88 | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of life measured by Disabkids-Questionaire (German version) | Measured by Disabkids-Questionaire (German version) and kid screen | 5 years | 
| Quality of life measured by questionaire kid screen | Measured by kid screen | 5 years | 
| Selective motor control | Measured by SCALE (Fowler et al., 2009) | 5 years | 
| Spasticity by modified Ashworth scale | Measured by modified Ashworth scale and Tardieu scale | 5 years | 
| Spasticity by modified Tardieu scale | Measured by modified Ashworth scale and Tardieu scale | 5 years | 
| Contractures by range of motion (ROM) | Measured by range of motion (ROM) | 5 years |
Satavaptan Dose-Ranging Study in Normonatraemic Patients With Cirrhotic Ascites

Study Overview
=================
Brief Summary
-----------------
The primary objective is to determine the optimal dose or range of doses of SR121463B for the treatment of ascites when used concomitantly with a standard dose regimen of spironolactone and furosemide. The secondary objective is to determine the tolerability of different fixed doses of SR121463B over a 14 day treatment period in cirrhotic ascites.

Official Title
-----------------
SR121463B in Cirrhotic Ascites Treatment With Normonatraemia: A Placebo-Controlled, Dose-Comparison Study

Conditions
-----------------
Ascites, Liver Cirrhosis

Intervention / Treatment
-----------------
* Drug: satavaptan (SR121463B)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Cirrhosis of the liver confirmed by ultrasound, endoscopic examination or biochemical evidence Moderate or tense ascites Serum sodium of >130 mmol/l. The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: satavaptan (SR121463B)|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in body weight |  | within 14 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Abdominal girth and discomfort |  | 14 days | 
| Paracentesis |  | 14 days | 
| Quality of life |  | 14 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cirrhotic ascites
Differences in Trends Malignant Germ Cell Tumors in Males and Females: A SEER Population-based Study

Study Overview
=================
Brief Summary
-----------------
Differences in 30-year Trends in Incidence and Survival for Malignant Germ Cell Tumors in Males and Females.

Detailed Description
-----------------
Differences in 30-year Trends in Incidence and Survival for Malignant Germ Cell Tumors in Males and Females: A SEER Population-based Study.

Official Title
-----------------
INST 0549C Differences in 30-year Trends in Incidence and Survival for Malignant Germ Cell Tumors in Males and Females: A SEER Population-based Study

Conditions
-----------------
Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Survival for Malignant Germ Cell Tumors in Males and Females.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |