Control and Intervention Programme on Alzheimer's Disease Risk Factors

Study Overview
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Brief Summary
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Recent epidemiologic studies are identifying a number of modifiable risk and protective factors that may influence in the incidence of Alzheimer's disease (AD). Therefore, the combination of an early detection of individuals at risk together with interventional studies targeted to the control of modifiable risk factors makes primary prevention programmes to become a new and real therapeutic strategy. In this scenario, the investigators have designed the ALFAlife study, a programme of control and intervention on the modifiable AD risk factors. Throughout this study, participants will be given a number of healthy lifestyle guidelines that are personalised depending on their specific risk profile. These guidelines refer to smoking and dietary habits and physical, cognitive and social activity. The investigators hypothesis is that the follow-up of these guidelines will favor a change of participants' lifestyle habits towards healthier ones. In addition, the investigators hypothesise that changes in these lifestyle habits will have an effect on objective physiological measures (such as blood pressure and cholesterol levels).

Official Title
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Control and Intervention Programme on Alzheimer's Disease Risk Factors

Conditions
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Alzheimer's Disease

Intervention / Treatment
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* Other: Lifestyle recommendations


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participants in the ALFA study (NCT01835717) Computer literacy Accept study's tests and procedures Signature of informed consent Exclusion Criteria: Cognitive impairment assessed by clinical criteria that, according to the investigator's evaluation could interfere with the study's follow-up. Anxiety or depression assessed by clinical criteria that, according to the investigator's evaluation could interfere with the study's follow-up. Visual and/or hearing impairment severe enough to impede tests realization. Major psychiatric or neurological disorder or other diseases that according to the investigator's evaluation could interfere with the study's follow-up. Antecedents of infarction, ischemic heart disease, stroke, peripheral vascular disease, stent or aneurysm clip

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 78 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Intervention<br> | Other: Lifestyle recommendations<br>* Dietary, and physical, cognitive and social activity recommendations<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Short Version of the Minnesota Leisure Time Physical Activity Questionnaire |  | 1 year; change between baseline and one year after | 
| Change in 14-item mediterranean diet Questionnaire |  | 1 year; change between baseline and one year after | 
| Change in Lifestyle Activities Questionnaire (LAQ) |  | 1 year; change between baseline and one year after | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Primary Prevention