Evaluation of the Heart's Respiratory Quotient as Predictive Value After Extra-hospital Cardiac Arrest

Study Overview
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Brief Summary
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It has been shown that elevation of the heart's respiratory quotient after cardiac surgery is predictive of the complications occurrence. In addition, a high heart's respiratory quotient is predictive of anaerobic metabolism after cardiac surgery. In the wake of cardiorespiratory arrest, the presence of anaerobic metabolism reflected by hyperlactatemia is an important prognostic factor. However, this monitoring is invasive and discontinuous. The hypothesis of the study is to show that a rise in the respiratory quotient by a non-invasive monitoring is a factor of poor prognosis in the wake of a Cardiac Arrest.

Official Title
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Evaluation of the Heart's Respiratory Quotient as Predictive Value After Extra-hospital

Conditions
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Cardiac Arrest

Intervention / Treatment
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* Other: non invasive monitoring value


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult >18 years Admission to intensive care unit after a non-hospital cardiopulmonary arrest. Resumption of spontaneous cardiac activity. Non-opposition of the patient or his relatives Exclusion Criteria: Pregnancy Prior neurological impairment Persons deprived of their liberty by a judicial proceeding, or administrative decision.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: non invasive monitoring value|heart's respiratory quotient as non invasive monitoring value|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart's respiratory value at H6 post intensive care unit admission to predict mortality | Physiological parameter | At 6 hours post intensive care unit admission | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart's respiratory value at intensive care unit admission to predict mortality | Physiological parameter | At admission of intensive care unit | 
| Heart's respiratory value at H12 post intensive care unit admission to predict mortality | Physiological parameter | At 12 hours post intensive care unit admission | 
| Heart's respiratory value at H24 post intensive care unit admission to predict mortality | Physiological parameter | At 24 hours post intensive care unit admission | 
| Heart's respiratory value at intensive care unit admission to predict neurological prognosis | Physiological parameter | At admission of intensive care unit | 
| Heart's respiratory value at H6 post intensive care unit admission to predict neurological prognosis | Physiological parameter | At 6 hours post intensive care unit admission | 
| Heart's respiratory value at H12 post intensive care unit admission to predict neurological prognosis | Physiological parameter | At 12 hours post intensive care unit admission | 
| Heart's respiratory value at H24 post intensive care unit admission to predict neurological prognosis | Physiological parameter | At 24 hours post intensive care unit admission | 
| metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at intensive care unit admission | Metabolic parameters | At admission of intensive care unit | 
| metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at H6 post intensive care unit admission | Metabolic parameters | At 6 hours post intensive care unit admission | 
| Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at H12 post intensive care unit admission | Metabolic parameters | At 12 hours post intensive care unit admission | 
| Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at H24 post intensive care unit admission | Metabolic parameters | At 24 hours post intensive care unit admission | 
| Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at intensive care unit admission | Metabolic parameters | At admission of intensive care unit | 
| Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at H6 post intensive care unit admission | Metabolic parameters | At 6 hours post intensive care unit admission | 
| Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at H12 post intensive care unit admission | Metabolic parameters | At 12 hours post intensive care unit admission | 
| Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at H24 post intensive care unit admission | Metabolic parameters | At 24 hours post intensive care unit admission | 
| Cardiac arrest circumstances following Utstein-style guidelines according mortality | Metabolic parameters | At admission of intensive care unit | 
| Cardiac arrest circumstances following Utstein-style guidelines according neurological prognosis | Cardiac arrest circumstances | At admission of intensive care unit | 
| Vital status at day 30 | Alive or Dead status | At 30 Days post intensive car unit admission | 
| Cerebral performance category (CPC) score at day 90 | Cerebral performance category (CPC) score : CPC=1 : Conscious, alert, and oriented with normal cognitive functions, CPC=2 : Conscious and alert with moderate cerebral disability; CPC=3: Conscious with severe disability; CPC=4: Comatose or in persistent vegetative state; CPC=5 : Certified brain death or dead by traditional criteria. | At 90 Days post intensive car unit admission | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Heart's respiratory quotient, Cardiac Arrest, Non-invasive monitoring, Poor prognosis