Role of Auditory Cortical Oscillations in Speech Processing and Dyslexia

Study Overview
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Brief Summary
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This study aims at investigating the role of low-gamma activity in phonemic encoding and its implication in dyslexia. Indeed, a phonological deficit, i.e. a difficulty in perceiving the sounds of speech, is strongly suspected in dyslexia but has never been conclusively associated with a specific underlying mechanism. The study employs transcranial alternating current stimulation in adults with and without dyslexia to exploit the effect of the stimulation on phonemic processing and neural activity measured with electroencephalography. In doing so, it would be possible to establishing a causal link between gamma oscillations and the phonological deficit in dyslexia.

Official Title
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Role of Auditory Cortical Oscillations in Speech Processing and Its Dysfunction in Dyslexia Through Transcranial Alternating Current Stimulation

Conditions
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Dyslexia

Intervention / Treatment
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* Device: Transcranial alternating current stimulation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18-65 years old; French native speakers; normally-hearing; intellectual quotient (IQ) around average; for the dyslexia group: previous diagnosis of dyslexia as assessed by a speech therapist. Exclusion Criteria: Presence of metal or electronic implants in the brain/skull; Presence of metal or electronic device at other in other parts of the body; Have experienced a seizure or a loss of consciousness or a severe head trauma; Severe brain related illness ; Intake of central nervous system-effective medication; Pregnant and nursing women; Relatives affected by epilepsy.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: tACS in individuals with and without dyslexia<br>Each participant in both the group of normo-readers and individuals with dyslexia receive all tACS stimulation conditions (fixed frequencies and sham) over different experimental days. | Device: Transcranial alternating current stimulation<br>* Focal transcranial stimulation over auditory cortex by means of 5 electrodes delivering an electric current (max. 2mA). In addition to active stimulation, also a placebo (sham) stimulation is employed as a control condition. All subjects included in the study receive all tACS stimulation conditions.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measure low-gamma neural oscillations with electroencephalography recordings | Auditory-steady state responses to auditory stimuli are measured to assess specific differences between individuals with dyslexia and normo-readers, and between the different tACS stimulation conditions before, after and 1h after the 20 min. tACS stimulation. These neural correlated are estimated by considering the power of EEG signal at the frequency used to modulate the auditory stimuli. | 6 hour | 
| Changes in linguistic performance through a battery of behavioral tests | Measurement of phonemic and syllabic processing (pseudoword repetition and spoonerism test), and reading (reading a 3 min. text, both accuracy and reading speed are considered) skills. These tests are repeated before, after and 1h after the tACS stimulation. | 6 hours |