fMRI Feasibility Older Hip Fracture Surgery

Study Overview
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Brief Summary
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An assessment of the feasibility of structural and functional magnetic resonance imaging (MRI) brain scans in older people who have recovered from and older people who never had delirium after hip fracture surgery

Detailed Description
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Postoperative delirium, an acute sate of confusion occurs with higher frequency in older people. Hip fracture surgery is a procedure associated with an increased risk of postoperative delirium. In the study the feasibility of achieving structure and functional connectivity imaging of the brain, using magnetic resonance imaging, in older people who are recovering from hip fracture surgery will be assessed. People who have recovered from post operative delirium and people who did not have postoperative delirium will be included.

Official Title
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Functional MRI in Older People Following Hip Fracture Surgery: a Feasibility Study

Conditions
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Magnetic Resonance Imaging, Hip Fractures, Postoperative Delirium

Intervention / Treatment
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* Diagnostic Test: Functional MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria:Age Age ≥ 65 years Cognitively intact primary admission for hip fracture surgery Exclusion Criteria: Cognitive impairment Less than moderate level of activities of daily living History of neurosurgery/significant head trauma Acutely unwell/moribund Presence of neurological diseases including overt stroke, dementia, multiple sclerosis, Parkinson's disease, intracranial tumours and other significant neurologic disorders. Postural or movement disorders likely to impede MRI scan Contraindications to MRI Complex fractures/multiple injuries

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Never had delirium<br>Older people recovering from hip fracture surgery who did not have postoperative delirium | Diagnostic Test: Functional MRI<br>* Series of MRI scans of the brain<br>|
| Recovered delirium<br>Older people recovering from hip fracture surgery who experienced delirium which has resolved | Diagnostic Test: Functional MRI<br>* Series of MRI scans of the brain<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Feasibility of MRI in older people following hip fracture surgery assessed by tolerability of transfer to scanner and the scanning process | The feasibility of transferring participants to and achieving structural and functional MRI scans. Specifically we will assess the number of participants in whom scans were successfully achieved | From time of consent to day after MRI scan which is up to 5 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Abnormalities of functional connectivity | Identify any differences in functional connectivity between the resolved delirium and the never delirium MRI scans | Up to one month after scans have been achieved | 
| Pain assessment. | An assessment of baseline pain levels and then repeat assessments of pain during transfer and the MRI scanning process using the numerical pain rating scale | From immediately prior to transfer to the MRI suite until return to own hospital bed which is approximately 2 hours | 
| Actual times taken to achieve scans | An assessment of unforeseen constraints on time taken to scan | Up to 60 minutes | 
| Participant feedback | The participant experience will be explored via verbal feedback which will be documented by the accompanying researcher | Two occassions. The first immediately after return from the MRI scan suite. The second will occur the day after scanning. Each will take 5 minutes. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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older people, postoperative delirium, Functional MRI