Outcome of Cataract Surgery With Uveitis

Study Overview
=================
Brief Summary
-----------------
Aim of the study is to evaluate outcome of cataract surgery in different types of uveitis as regarding best corrected visual acuity (BCVA) and rate of post operative complications.

Detailed Description
-----------------
Cataract is the main cause of reversible blindness in patients with uveitis. Cataract occurs in up to 50% to 70% of patients with uveitis. Preoperative complications, including anterior synechiae, posterior synechiae, and pupillary membrane formation, may increase surgical challenges. In addition, recurrent inflammation increases the incidence of postoperative complications and often affects the visual prognosis. In recent years, phacoemulsification with intra ocular lens (IOL)implantation has become the main surgical method for treating uveitis (complicated cataract), and the visual prognosis of patients who undergo this procedure is usually favorable. Surgical treatment may be effective but is associated with higher rates of complication than in non uveitic eyes. Cystoid macular edema (CME) is the most common complication cataract surgery in the general population. Although, in most cases, the macular edema is self-limited, in rare cases it can lead to long-term visual deterioration that is difficult to treat. Another common complication after cataract surgery is posterior capsule opacification (PCO) , leading to symptoms of glare or blurred vision, reduced visual acuity, or impaired posterior segment exam. Factors that are critical in the development of PCO include surgical technique, type of implanted intra ocular lens (IOL) either foldable hydrophilic acrylic, hydrophobic acrylic or silicone and postoperative control of uveitis

Official Title
-----------------
Outcome of Cataract Surgery in Patient With Uveitis

Conditions
-----------------
Cataract; Complicata

Intervention / Treatment
-----------------
* Procedure: cataract surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Visually significant cataract ( means opacification of the crystalline lens adequate to interfere with vision)in patients with uveitis controlled for at least 1month. Exclusion Criteria: Irreversible pathology affecting outcome e.g. macular scar ,optic atrophy, and retinal detachment. Patients with active uveitis (means inflammation inside the eye). Patients less than 16 years old.

Ages Eligible for Study
-----------------
Minimum Age: 16 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Uncorrected and best corrected visual acuity<br>Measuring of uncorrected and best corrected visual acuity after phaco emulsification and irrigation aspiration cataract surgery | Procedure: cataract surgery<br>* cataract surgery in form of phaco emulsification or irrigation aspiration<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| final postoperative uncorrected visual acuity (UCVA) | post operative uncorrected visual acuity which mean visual acuity without spectacle correction | 1 week post operative | 
| final postoperative uncorrected visual acuity (UCVA) | post operative uncorrected visual acuity which mean visual acuity without spectacle correction | 1month post operative | 
| final postoperative uncorrected visual acuity (UCVA) | post operative uncorrected visual acuity which mean visual acuity without spectacle correction | 3months post operative | 
| final postoperative uncorrected visual acuity (UCVA) | post operative uncorrected visual acuity which mean visual acuity without spectacle correction | 6months post operative | 
| Final post operative best corrected visual acuity (BCVA) | Post operative visual acuity with spectacle correction | 1 week post operative | 
| Final post operative best corrected visual acuity (BCVA) | Post operative visual acuity with spectacle correction | 1month post operative | 
| Final post operative best corrected visual acuity (BCVA) | Post operative visual acuity with spectacle correction | 3months post operative | 
| Final post operative best corrected visual acuity (BCVA) | Post operative visual acuity with spectacle correction | 6months post operative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| incidence of postoperative complications | cystoid macular edema which mean inflammation, swelling and collection of fluid inside macula) . | 6 months post operative | 
| Reactivation of intraocular inflammation | Appearance of inflammatory activity inside the eye after period of quiescence of at least 6 months | 6 months post operative | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
uveitis