Antibiotic Prophylaxis for TEVAR

Study Overview
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Brief Summary
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The infection rate of thoracic endovascular aortic repair (TEVAR) is unknown due to a lack of epidemiological data. The rate currently available comes from researches conducted decades ago, when open surgery was the standard of care. Because of the potentially fatal consequences of a stent graft infection in the thoracic aorta, the investigators tend to prescribe antibiotic prophylaxis for at least three days. In this study, the investigators are going to collect data on patients receiving TEVAR in the past five years and provide the following information: a. the infection rate (MAGIC classification), b. the rate of fever, c. the results of the lab tests, such as the WBC count and C-reaction protein. d. risk factors associated with infection and fever.

Official Title
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Antibiotic Prophylaxis for Thoracic EndoVascular Aortic Repair

Conditions
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Aortic Dissection, Aortic Diseases, Aortic Aneurysm, Thoracic, Coarctation of Aorta, Hematoma; Aorta

Intervention / Treatment
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* Procedure: thoracic endovascular aortic repair


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosed with thoracic aortic diseases Received TEVAR Exclusion Criteria: Suspected infectious aortic disease, such as a mycotic aneurysm. TEVAR combined with open surgery Antibiotics have been used more than 24 hours before the operation Combined with immune deficiency disease or using hormone or immunosuppressant； The treatment is for the complications of TEVAR, such as endoleak Endovascular aortic repair for abdominal aortic disease History of open aortic surgery or heart surgery. Revascularization of visceral arteries during the TEVAR
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients receiving TEVAR<br> | Procedure: thoracic endovascular aortic repair<br>* In The TEVAR procedure, we implant a stent graft into the diseased area of the thoracic artery, providing a route for the blood to flow within the stent graft and excluding the diseased aorta.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Infection rate after TEVAR | Infection rate via MAGIC classification | during hospitalization (up to post-operation day 14) | 
| Infection rate at one month after TEVAR | Infection rate via MAGIC classification | One month after TEVAR | 
| Infection rate at six months after TEVAR | Infection rate via MAGIC classification | Six months after TEVAR | 
| Infection rate at one year after TEVAR | Infection rate via MAGIC classification | One year after TEVAR | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fever | Defined as temperature ≥38.5℃ | one day, two days, three days, one month, six months, one year after TEVAR | 
| WBC count |  | one day, two days, three days after TEVAR | 
| C-reaction protein |  | one day after TEVAR | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Antibiotic prophylaxis, TEVAR, Fever, MAGIC classification