linjc16/ctgov huggingface dataset:
A Comparison of Propofol Based Total Intravenous Anesthesia and Desflurane Based Balanced Anesthesia on Hepatic Protection During Living-donor Liver Transplantation

Study Overview
=================
Brief Summary
-----------------
Renal ischemia/reperfusion (I/R)-induced injury is known to be associated with immediate and long-term hepatic dysfunction after liver transplantation. Protecting the liver against I/R injury and maintaining hepatic function during transplant surgery is therefore very important in order to improve post-operative outcome. This purpose of this study is to investigate whether propofol anesthesia done in both liver donors and recipients during living-donor liver transplantation is effective in reducing liver I/R injury via its antioxidant and antiinflammatory properties and improve post-transplant outcome compared to desflurane anesthesia.

Conditions
-----------------
End Stage Liver Disease

Intervention / Treatment
-----------------
* Drug: Desflurane balanced anesthesia
* Drug: Propofol total intravenous anesthesia


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: (1) Adult liver donors and recipients scheduled for liver transplantation Exclusion Criteria: Patient refusal Hypersensitivity to propofol, soybeans or peanuts History of vitamin C or E intake within 5 days before surgery History of acute myocardial infarct within 6 months before surgery Congestive heart failure (NYHA III-IV) Autoimmune disease patients BMI over 30 kg/m2 Left ventricular ejection fraction less than 35% upon preoperative echocardiography

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Desflurane balanced anesthesia group<br> | Drug: Desflurane balanced anesthesia<br>* Desflurane balanced anesthesia induced with thiopental sodium, remifentanil and atracurium and maintained with remifentanil target controlled infusion and desflurane inhalation<br>|
| Active Comparator: Propofol total intravenous anesthesia group<br> | Drug: Propofol total intravenous anesthesia<br>* Propofol total intravenous anesthesia induced with propofol, remifentanil and atracurium and maintained with remifentanil and propofol target controlled infusion<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hepatic function | The difference in hepatic function of recipients between groups after liver transplantation (PT, aPTT, albumin, bilirubin, platelet count, AST, ALT, lactate, triglyceride, ammonia) | from 48hr before anesthesia, 1 hour after reperfusion, 1 hour after end of operation, every 24 hours daily up to 7 days postoperatively |
A Trial To Evaluate The Efficacy of Magnetic Resonant Therapy in Autism

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to show that a magnetic field applied to the front part of the brain of children suffering from Autism Spectrum Disorder(ASD) can improve function and ameliorate symptoms.

Official Title
-----------------
A Randomized Double-Blind Sham-Controlled Trial To Evaluate The Treatment Efficacy of Magnetic Resonant Therapy in Autistic Disorder

Conditions
-----------------
Autism Spectrum Disorder

Intervention / Treatment
-----------------
* Device: MRT-Active
* Device: MRT-SHAM


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Primary diagnosis of Autism Spectrum Disorder by DSM-IV-TR rendered by the examination and sufficient CARS-2 score to qualify as autism. CARS score between 36 and 47 inclusively Age between 4 and 12 years (at day of informed consent) Child must suffer disrupted sleep patterns defined as a minimum of 3 nights per week of delayed onset of sleep or night-time awakenings. If these are medicated with mild sedatives or melatonin and corrected, the requirement for medication or melatonin will qualify as evidence of a sleep disorder. Exclusion Criteria: Diagnosis of Asperger's Disorder, Pervasive Developmental Disorder Not Otherwise specified History of clinically significant traumatic brain injury Any condition associated with increased intracranial pressure Cerebral Aneurysm Down's Syndrome or other chromosomal abnormality EEG abnormalities that indicate seizure risk Intracranial implant Unstable medical condition not otherwise specified Clinically significant organic disease unrelated to autism

Ages Eligible for Study
-----------------
Minimum Age: 4 Years
Maximum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: MRT-Active<br>Magnetic Field, modulated as per EEG analysis, is active for 6 seconds every minute for 30 minutes per day, 5 days per week x 5 weeks. | Device: MRT-Active<br> <br> |
| Sham Comparator: MRT-SHAM<br>Magnetic field is not active, but a sham coil is used, for 6 seconds every minute for 30 minutes per day, 5 days per week x 5 weeks. | Device: MRT-SHAM<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Childhood Autism Rating Scale (CARS) | Difference in CARS score between start and end of double-blind portion of the study | 5 Weeks |
Feasibility of a Non-invasive, Trans-abdominal, Low Cost Fetal Oximetry Probe on Pregnant Human Subjects

Study Overview
=================
Brief Summary
-----------------
Three non-invasive, trans-abdominal fetal oximetry probes will be tested on pregnant human subjects, in order to obtain fetal heart rate. We want to determine if this device can accurately measure a baby's oxygen level when placed on your abdomen. Current technology to measure a baby's oxygen levels requires a probe to be inserted into the vagina.

Detailed Description
-----------------
The study subject will have a brief trans-abdominal ultrasound examination. 3 trans-abdominal fetal oximetry probes will be tested for 5 minutes per probe. No probes will be placed into the vagina. It is anticipated that 6 months will be required to recruit, consent and study 25 participants.

Official Title
-----------------
Feasibility of a Non-invasive, Trans-abdominal, Low Cost Fetal Oximetry Probe on Pregnant Human Subjects

Conditions
-----------------
Pregnancy, Abdominal

Intervention / Treatment
-----------------
* Device: Raydiant Oximetry Sensor System


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Greater than 36 weeks pregnant Singleton fetus Exclusion Criteria: Prisoners

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Device Feasibility
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Administration of Fetal Oximetry Probe<br>Administration of Raydiant Oximetry Sensor System on 36 weeks or greater pregnant women | Device: Raydiant Oximetry Sensor System<br>* Administration of Fetal Oximetry Probe on 36 weeks or greater pregnant women<br>* Other names: ROSS;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fetal Photoplethysmogram | The primary outcome measure will be if a fetal photoplethysmogram is obtained in the time domain that correlates to the fetal heart rate. | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fetal Heart Rate | The secondary endpoint will be if fetal heart rate can be obtained in the frequency domain that correlates to a fetal heart rate obtained by Doppler. | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
pregnancy, fetal monitoring, fetal oximetry, fetal heart rate, pulse oximetry, near infrared spectroscopy
The Effect of the Educatıon and Counselıng of Prostatectomy Patıents

Study Overview
=================
Brief Summary
-----------------
The research was planned as a randomized controlled experimental study. This study is planned to be conducted in the Urology clinic of a university hospital located in the south of Turkey. The population of the research will be the patients admitted to the urology clinic for prostatectomy. The sample of the study will consist of patients who meet the criteria for participation in the study and volunteer to participate in the study. Evaluation of the research data will be done with the SPSS package program.

Official Title
-----------------
The Effect of educatıon and counselıng gıven to patıents patıent wıth Prostatectomy on qualıty of lıfe

Conditions
-----------------
Prostate Cancer, Surgery, Nursing Caries

Intervention / Treatment
-----------------
* Other: education


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Being 18 years or older, Being literate, Being able to understand and speak Turkish and not have a hearing impairment, Agreeing to participate in the research. Exclusion Criteria: Development of any complications during the surgical intervention, Having any psychiatric disorder that will reduce the ability to comprehend and understand, Having other concomitant cancer, Having metastases.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: experiment group<br>In addition to standard care, patients will be given discharge training, planned within the framework of the Life model, one day before discharge. It is planned that the discharge training will be given by the researcher in the patient's room and by providing an accompanying person. Written training material will be delivered to the patients for their re-use after the training. | Other: education<br>* Oral and written education according to the life model<br>|
| No Intervention: control group<br>standard care will be applied | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect of traınıng and counselıng gıven after prostatectomy on qualıty of lıfe | It will be measured with SF-12. Measurement will be made before and after the application. It is evaluated between 0 and 100 points, with a higher score representing better health. | six months |
Quality of Life in Advanced Gastric Cancer Patients Receiving Neoadjuvant Chemotherapy

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to explore the influence of neoadjuvant chemotherapy in the long term quality of life with advanced gastric cancer patients.

Detailed Description
-----------------
Preoperative adjuvant chemotherapy combined with postoperative adjuvant therapy mode was included in the 2018 version of the National Comprehensive Cancer Network (NCCN) guideline as an optional treatment (category 2B) for prospective resectable advanced gastric cancer cases (≥cT2, any N).At home and abroad, the research on neoadjuvant chemotherapy for advanced gastric cancer mainly focuses on the safety and long-term survival, and there are few studies on the quality of life. This study, according to EORTC QLQ-C30 and QLQ-STO22 assessment scale, explores the long term effect of neoadjuvant chemotherapy on the quality of life in patients with advanced gastric cancer.

Official Title
-----------------
Quality of Life in Patient With Neoadjuvant Chemotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Gastric Cancer

Conditions
-----------------
QOL; Quality of Life;Gastric Cancer; Gastrectomy;Neoadjuvant Chemotherapy

Intervention / Treatment
-----------------
* Drug: Neoadjuvant Chemotherapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients age older than 18 years (including 18 years old); Diagnosis of adenocarcinoma of the stomach The clinic stage is ≥T2 and any N stage Patient had curative surgical resection, including proximal, distal, or total gastrectomy Exclusion Criteria: Psychiatric or psychological abnormality precluding informed consent or ability to complete questionnaires Non-psychiatric disorder causing a lack of capacity to give consent or an inability to complete questionnaires (ie dementia, stroke) Early gastric cancer.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| NACS<br>The patients with advanced gastric cancer who received neoadjuvant chemotherapy followed by surgery（NACS）. | Drug: Neoadjuvant Chemotherapy<br>* The patients receive neoadjuvant chemotherapy for 2-4 cycles before surgery.<br>|
| SA<br>The patients with advanced gastric cancer who received surgery alone. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of life index | The change of quality of life index during the 2 years after surgery. | 2 years |
Cardiovascular Risk Factors And Intensive Dietary Counselling

Study Overview
=================
Brief Summary
-----------------
The Intensive Dietary Counselling (IDC) intervention is a prevention and health promotion activity. It is being implemented by the Andalusian Health Service to reinforce basic intervention advice on healthy diet and exercise. The IDC intervention is aimed at the prevention of diseases of the heart and blood vessels (e.g. heart failure, heart attack and stroke). The main objective of the present study is to assess adherence to the IDC intervention and, consequently, its effectiveness on the prevention of the above mentioned diseases.

Official Title
-----------------
Estimation of Cardiovascular Risk After Intensive Dietary Counselling in a Primary Care Setting

Conditions
-----------------
High Blood Pressure, Hypercholesterolemia, Tobacco Smoking

Intervention / Treatment
-----------------
* Behavioral: Group-level Intensive dietary Counselling
* Behavioral: Individual-level Intensive Dietary Counselling


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age between 40-65 years Presence of any cardiovascular risk factors (Hypertension, Hypercholesterolemia, tobacco smoking, diabetes, obesity) Exclusion Criteria: Currently diagnosed with any vardiovascular disease Currently involved in any other clinical trial Cognitive impairment that prevents from providing an informed consent

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Group-level Intensive Dietary Counselling<br>Active learning through 4-6 60-minute sessions workshop, enrolling 8-12 people each time. | Behavioral: Group-level Intensive dietary Counselling<br> <br> |
| Active Comparator: Individual-level Intensive Dietary Counselling<br>Individualised dietary counselling delivered at the health-care point | Behavioral: Individual-level Intensive Dietary Counselling<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiovascular risk as calculated by means of the SCORE (Systematic Coronary Risk Evaluation) scale. Low-risk regions version. |  | upt to 12 months from the beginning | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Health-Related Quality of Life | Spanish version of the EQ-5D-5L questionnaire by the EuroQol Group | Baseline, 6 and 12 months from the beginning | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cardiovascular risk, Primary prevention, Intensive dietary counselling, Physical exercise
Capillary Refill for Assessment of Dehydration

Study Overview
=================
Brief Summary
-----------------
Capillary refill is used clinically to assess multiple things in children. This is a prospective observational study of the correlation between capillary refill time and degree of dehydration in children seen in a pediatric ED.

Detailed Description
-----------------
All patient presenting to the pediatric ER at OHSU less than 10 years are eligible to be enrolled if being seen for a condition putting them at risk for dehydration including emesis, diarrhea, etc. Children will have their capillary refill time measured and then sent home with a digital scale to track their weight. This will serve as the standard for calculating percent dehydration. When a patient has reached a stable weight at 1 week we will assume this is their healthy weight. There is no intervention in the study.

Official Title
-----------------
Capillary Refill to Detect Dehydration in Children

Conditions
-----------------
Dehydration in Children

Intervention / Treatment
-----------------
* Diagnostic Test: Capillary Refill


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All children with chief complaint of diarrhea, emesis, nausea, abdominal pain Exclusion Criteria: Any child with chronic cardiac or pulm disease, raynauds syndrome, bilateral upper extremity trauma, previously enrolled in the study, already received IVF in the previous 48hrs, surgery within 1week, osteogenesis imperfecta.

Ages Eligible for Study
-----------------
Minimum Age: 6 Months
Maximum Age: 10 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Capillary Refill|We are measuring capillary refill to assess it's correlation with dehydration in children|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Capillary Refill time | Assessing correlation of the refill time and percent dehydration | 1 week |
Preoperative Anxiety and Postoperative Pain in Children

Study Overview
=================
Brief Summary
-----------------
We wish to study which method of local injection of analgesic (before or during surgery) is the more effective method to reduce post-operative pain in children. In addition, we wish to study which pre-operative educational intervention is more effective in reducing anxiety in children and their family.

Official Title
-----------------
Comparison of 2 Methods to Reduce Postoperative Pain in Children and a Comparison of 3 Methods of Preoperative Education Intervention to Reduce Anxiety in Children and Their Family

Conditions
-----------------
Post-Operative Pain, Pre-Operative Anxiety

Intervention / Treatment
-----------------
* Procedure: Transcutaneous iliohypogastric
* Procedure: Perioperative administration near the nerve


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy ASA I - II Undergoing elective day surgery Exclusion Criteria: Known coagulation dysfunction Sensitivity to analgesics

Ages Eligible for Study
-----------------
Minimum Age: 3 Months
Maximum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: I<br> | Procedure: Transcutaneous iliohypogastric<br> <br> |
| Active Comparator: II<br> | Procedure: Perioperative administration near the nerve<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
The Coherex FlatStent™ EF PFO Migraine Registry

Study Overview
=================
Brief Summary
-----------------
A prospective, single arm, multicenter clinical registry evaluating the change in migraine headaches in migraine with aura patients who undergo patent foramen ovale (PFO) closure with the Coherex FlatStent™ EF PFO Closure System.

Official Title
-----------------
The Coherex PFO Migraine Registry

Conditions
-----------------
Patients With Migraine and PFO

Intervention / Treatment
-----------------
* Device: Transcatheter PFO Closure


Participation Criteria
=================
Eligibility Criteria
-----------------
Major Inclusion Criteria: Age 18-65 males and non pregnant females History of refractory migraine Documented PFO Major Exclusion Criteria: Known allergy to aspirin or nickel. Medication Overuse Headache Body mass index > 40. Recent Botulinum neurotoxin type A treatment Other known structural heart disease, coronary artery disease, atrial fibrillation PFO morphology not suitable for FlatStent EF Patients who have had a stroke within the past two months Post-traumatic headache. Patients with diagnosed hypercoagulable states that require chronic treatment with warfarin.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Transcatheter PFO Closure|Transcatheter PFO Closure|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Efficacy | Percentage of subjects treated with the FlatStent EF who, achieve a clinically significant reduction in migraine or probable migraine headache days at follow-up. |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Closure efficacy | Degree of closure of PFO at follow-up |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Migraine