linjc16/ctgov huggingface dataset:
Are Patients Suffering From DSPS Show Compromising in Everyday Functions and Abilities Before Handling the Disorder?

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine whether the known treatment for DSPS also improve the cognitive ability and mood of the patients.

Detailed Description
-----------------
Every participant will take a few test and tasks that are going to test his cognitive ability and mood before treatment in 08:00 and 20:00, and again the same tests at the same hours after the treatment.

Official Title
-----------------
Are Patients Suffering From DSPS Show Compromising in Everyday Functions and Abilities (Attention and Concentration, Mood and Fatigue) Before Handling the Disorder? And Whether the Treatment Fixes the Disorder?

Conditions
-----------------
Delayed Sleep Phase Syndrome

Intervention / Treatment
-----------------
* Other: Melatonin and light therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: diagnosed with DSPS Exclusion Criteria: attention deficit hyperactivity disorder - diagnosed, affective disorder- diagnosed

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Base line<br>the subject will take the tests in the morning and the evening | |
| Experimental: After treatment<br>the subject will take the tests in the morning and the evening | Other: Melatonin and light therapy<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sleep patterns | Sleep actigraph | 1 week | 
| Melatonin secretion | Melatonin -Sulfate Urine | 12 hours | 
| Brief Symptom Inventory | BSI Questionnaire- assess the subject's emotional state | 1 day | 
| Epworth Sleepiness Scale | ESS Questionnaire- measure daytime sleepiness | 1 day | 
| Karolinska Sleepiness Scale | KSS Questionnaire- self-reported, subjective assessment of the subject's level of drowsiness | 1 day | 
| Continuous Performance Test 3 | Task-oriented computerized assessment of attention-related problems | 1 day |
Cocaine Opioid Oxytocin Option - Limited

Study Overview
=================
Brief Summary
-----------------
This is a pilot feasibility study assessing the tolerability of chronic administration of intranasal oxytocin to patients receiving methadone at an opioid replacement clinic who are actively using cocaine.

Official Title
-----------------
Chronic Intranasal Oxytocin as an Adjunct to Methadone Maintenance Treatment in Patients With Co-occuring Opioid Use Disorder and Cocaine Use: A 2-week Pilot Study

Conditions
-----------------
Opioid Use Disorder, Cocaine Use Disorder

Intervention / Treatment
-----------------
* Drug: Oxytocin
* Drug: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Enrolled as a patient in the San Francisco General Hospital Opioid Treatment Outpatient Program Stable dose of methadone for at least the past two weeks At least one routine urine toxicology screen positive for cocaine in the past month Exclusion Criteria: Positive urine pregnancy test Use of illicit drugs in the past month (with the exception of cocaine or cannabis) Currently meets Diagnostic and Statistical Manual-5 (DSM-V) criteria for severe major depressive disorder with suicidal thoughts or actions History of psychotic or moderate-severe alcohol use disorder as defined by DSM-V criteria Severe neuropsychological disorder, brain trauma, epilepsy Sensitivity to preservatives (in particular E 216, E 218 and chlorobutanol hemihydrate) Nasal obstruction, discharge, or bleeding Habitually drinks large volumes of water Taking testosterone, estrogen/progesterone supplement, or serotonin-1a receptor agonists/antagonists

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Patients 1<br>Participants will receive intranasal oxytocin 40 International Units (IU). | Drug: Oxytocin<br> <br> * Other names: oxytocin nasal spray, Syntocinon;|
| Placebo Comparator: Patients 2<br>Participants will receive 40 International Units of intranasal placebo. | Drug: Placebo<br> <br> * Other names: placebo nasal spray;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with non-serious and serious adverse events |  | 3 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
addiction, oxytocin, tolerability
Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia

Study Overview
=================
Brief Summary
-----------------
Many anesthesiologists use the Remifentanil for reducing a surgical pain and stabilizing a vital sign. However, this drug induce postoperative hyperalgesia. Nowadays, many studies report that low-dose Ketamine prevents the opioid-induces hyperalgesia. Nefopam,which is non-opioid analgesic, has similar mechanism with Ketamine. It will be helpful for postoperative pain control, and reduce the needs of opioid.

Conditions
-----------------
Cholecystitis

Intervention / Treatment
-----------------
* Drug: Nefopam
* Drug: Ketamine
* Drug: Saline


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patient who scheduled laparoscopic cholecystectomy under general anesthesia American Society of Anesthesiologist(ASA) class I or II adult patient (age 20 - 65) Exclusion Criteria: patient who has liver disease patient who has kidney disease patient who has diabetes mellitus(DM) or heart disease patient who takes opioid or beta-blocker patient who has airway disease patient who has allergy with the drug

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Nefopam<br>The generic name is 'ACUPAN'. It is infused during operation. A induction dose is 0.3mg/Kg. A maintenance dose is 65 mcg/kg/hr | Drug: Nefopam<br> <br> |
| Active Comparator: Ketamine<br>It is infused during operation. A induction dose is 0.3 mg/Kg. A maintenance dose is 3 mcg/kg/hr | Drug: Ketamine<br> <br> |
| Placebo Comparator: Saline<br>It is infused during operation. A induction volume is 3mL A maintenance dose is 10mL/hr | Drug: Saline<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| analgesic requirement |  | During 1 hour at PACU | 
| duration of analgesic free |  | During 1 hour at PACU | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| analgesic requirement |  | During 8 hours after arriving at ward | 
| Pain on the VAS scale |  | During 1 hour at PACU |
Conventional Neck Exercise With and Without Scapular Corrective Exercises in Patients With Forward Head Posture

Study Overview
=================
Brief Summary
-----------------
To determine the effects of conventional neck exercises with and without scapular corrective exercises on pain, cervical range of motion and disability in patients with forward head posture

Official Title
-----------------
Effects of Conventional Neck Exercise With and Without Scapular Corrective Exercises on Pain, Cervical Range of Motion and Disability in Patients With Forward Head Posture

Conditions
-----------------
Forward Head Posture

Intervention / Treatment
-----------------
* Other: scapular corrective exercises
* Other: conventional neck exercises


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: forward head posture complain of pain for at least 3months no history of any therapeutic interventions for the last 3months Exclusion Criteria: history of whiplash injury any cervical surgery previous history of significant trauma fracture of cervical or scapula neurological impairments cervicogenic head ache

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: conventional neck exercises & scapular corrective exercise<br>isometric & stretching exercises of neck plus scapular corrective exercise | Other: scapular corrective exercises<br>* 40 minutes each, three times a week for six weeks<br>Other: conventional neck exercises<br>* 40 minutes each, three times a week for six weeks<br>|
| Active Comparator: conventional neck exercises<br>isometric & stretching exercises of neck | Other: conventional neck exercises<br>* 40 minutes each, three times a week for six weeks<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Numeric pain rating scale | it is a subjective measure in which individuals rate their pain on an eleven point numeric scale. It is composed of 0(no pain at all) to (worst imaginable pain) | 6 weeks | 
| Goniometry | A goniometer is a device that measures an angle or permits the rotation of anobject to a definite position | 6 weeks | 
| Neck disability index (NDI) | s a self-reported questionare with 10 items including pain, personal care, lifting, reading, headaches, concentration, work, driving, sleeping and recreation | 6 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Forward head posture, Neck pain, conventional neck exercises, scapular corrective exercises
The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical Findings

Study Overview
=================
Brief Summary
-----------------
The investigators compare the treatment results and clicical presentations of different Molecular subtyping of Treponema pallidum

Conditions
-----------------
Syphilis

Intervention / Treatment
-----------------
* Drug: Benzathine Penicillin G


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria 1. Persons with confirmed early symptomatic syphilis (primary or secondary) or high-titer latent syphilis Exclusion Criteria: Pregnant woman Known allergy to penicillin RPR titers were found to be 1:8 or less

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Molecular subtyping (14d/f) of Treponema pallidum<br>Benzathine Penicillin G treatment | Drug: Benzathine Penicillin G<br> <br> |
| Experimental: Molecular subtyping (others) of Treponema pallidum<br>Benzathine Penicillin G treatment | Drug: Benzathine Penicillin G<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rapid plasma regain titer |  | 6 months after treatment |
Assessment of Dissociative Traumatic Disorders

Study Overview
=================
Brief Summary
-----------------
More than 70% of ambulatory patients with IDD have attempted suicide (APA, 2015). This disorder, as well as all the disorders on the dissociation spectrum, must therefore be clarified and better diagnosed. The goal of this research is : to assess the prevalence of dissociative disorders using specific tools in patients suffering from PTSD. to validate the French version of the DDIS interview (Ross, 1997) that the investigators have translated.

Official Title
-----------------
Assessment of Dissociative Traumatic Disorders

Conditions
-----------------
Posttraumatic Stress Disorder

Intervention / Treatment
-----------------
* Other: self-assessment and hetero-assessment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient diagnosed with PTSD according to DSM 5 criteria Over 18 years of age Informed consent signed Exclusion Criteria: Neurological disorders Serious and/or unstable somatic pathologies Patient not affiliated with social security Patient hospitalized under restraint in psychiatric care by decision of the state representative or in psychiatric care at the request of a third party Patient under guardianship Patient participating in parallel in another biomedical research Change of antidepressant in the last three months Patient not mastering the French language

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Interventional Model Description: All patients with a diagnosis of Post Traumatic Stress Disorder will be seen by a physician psychiatrist or psychologist who will introduce them to the study. They will be given an information letter and a consent form. If patients agree to participate in the study, and after signing the consent form, they will be included and will complete the assessment scales.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Posttraumatic stress disorder<br>cohort of patients with Posttraumatic stress disorder PTSD | Other: self-assessment and hetero-assessment<br>* Self assessment for the passing of the following rating scales CTQ-SF36-ITQ-PCL5-DES Hetero-assessment for the pasing of the following rating scales DDIS FR and medical interview<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Post Traumatic Stress | assessment of the prevalence of dissociative disorders in a cohort of patients with PTSD | 1 year |
Study of Tissue Expansion Devices Complications

Study Overview
=================
Brief Summary
-----------------
Reduce the common complications incidence about patients placed tissue expansion devices to around 5%.

Detailed Description
-----------------
Study design： Randomized parallel controlled trial. Study comments: 1.Telephone follow-up trainment group about 2-3 months until secondary hospital. 2.Promote the health management manual of patient placed expander,which includes discharge list, injection list, expander affusion operation procedure, injection myth, you ask me answer,injection record, injection diary record, appointment diaries etc.

Official Title
-----------------
Intervention Study of Common Complications About Patients Placed Tissue Expansion Devices

Conditions
-----------------
Tissue Expansion

Intervention / Treatment
-----------------
* Behavioral: manuals and follow-up


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: aged 1-70 years male and female; no complication when inclusion; sign the informed consent. Exclusion Criteria: joined other clinical trial; occurred complications before inclusion; other infectious diseases; the pregnant or lactating women.

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: manuals and follow-up<br>distribute manuals for patients before discharge and telephone follow-up per week until secondary hospital | Behavioral: manuals and follow-up<br>* distribute manuals for patients before discharge and telephone follow-up per week until secondary hospital<br>|
| No Intervention: controlled group<br>no intervention until secondary hospital | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| incidence of patients suffered the common complications | count up the number of patients suffered the common complications | 2-3 months until secondary hospital | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Tissue Expansion Devices, Tissue Expansion, common complications, intervention study
Plasma Citrulline Level in Relation to Absorptive Surface

Study Overview
=================
Brief Summary
-----------------
Correlation between determination of citrulline in plasma or dried blood Reference ranges for healthy children and babies Longitudinal follow-up of citrulline in preterm babies

Official Title
-----------------
Plasma Citrulline Level in Relation to Absorptive Surface

Conditions
-----------------
Intestinal Failure

Intervention / Treatment
-----------------
* Procedure: Blood sampling


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 0-18 years preterm babies up to 1.500g preterm babies over 1.500g Exclusion Criteria: gastro-intestinal problems (except for the preterm babies) congenital metabolic disorders dysfunction of the liver or kidneys congenital defects

Ages Eligible for Study
-----------------
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Blood sampling|Blood sampling is used.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between determination of citrulline in plasma or dried blood |  | Untill end of study | 
| Reference ranges for healthy children and babies |  | Until end of study | 
| Longitudinal follow-up of citrulline in preterm babies |  | Untill end of study |
Adequacy of Pain Treatment in Radiotherapy

Study Overview
=================
Brief Summary
-----------------
Aim of the study is to evaluate adequacy of pain treatment in oncologic patients, accessing to Radiotherapy Unit

Detailed Description
-----------------
Prescription of analgesic drugs is a basic topic in cancer patients, but undertreatment is common. The aim of the study is to analyse pain control and adequacy of antalgic treatments in patients coming to Radiotherapy Unit for radiation treatment.

Official Title
-----------------
Adequacy of Pain Treatment in Radiotherapy: an Observational, Prospective, Multicenter Study (ARISE)

Conditions
-----------------
Cancer Pain, Analgesic Drugs

Intervention / Treatment
-----------------
* Other: Patients accessing to Radiotherapy Unit


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - patients accessing to Radiotherapy Unit for radiation treatment (both palliative or with radical intent) with diagnosis of primitive or metastatic cancer; Exclusion Criteria: - Concomitant diseases that can affect reliability of collected data

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients accessing to Radiotherapy Unit<br>patients accessing to Radiotherapy Unit for oncologic treatment | Other: Patients accessing to Radiotherapy Unit<br>* No intervention; information about patient and disease characteristics will be recorded as well as information about pain and analgesic treatment<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of adequacy of pain treatment | For all patients, Visual Analogue Scale (VAS) and information about type of analgesic drugs (no drugs; non-opioid drugs; weak opioids; strong opioids) will be recorded and analysed | 2 months |