linjc16/ctgov huggingface dataset:
Differences Between Breastfed and Formula Fed Infants

Study Overview
=================
Brief Summary
-----------------
This study will help us learn how a child's diet affects growth and development.

Detailed Description
-----------------
This study will see how infants diet affects their growth and development. Up to 170 infants will be enrolled for one visit.

Official Title
-----------------
Microbiota Differences Between Breastfed and Formula Fed Infants

Conditions
-----------------
Healthy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Exclusive breast feeding or cow milk formula feeding during the first 3 months of life. For formula feeders, exclusively on Similac Advance Formula for at least 1 month prior to visit Age 2.5-3.5 months Exclusion Criteria: Infants born to mother with preexisting medical conditions. Infants born to mother with medications during pregnancy known to influence fetal growth. Infants born to smoking, alcohol drinking or drug use mothers during pregnancy. Preterm

Ages Eligible for Study
-----------------
Minimum Age: 2 Months
Maximum Age: 3 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Breast Fed<br>Exclusively breastfed for first 3 months of life | |
| Milk-based formula fed<br>Exclusively on Similac Advance Formula for at least 1 month prior to visit | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The role of microbiota in gut | Stool samples will be collected | 2.5-3 months | 
| The role of microbiota in immune system development | Stool samples will be collected | 2.5-3 months |
Real-time Ultrasound Guided Labor Epidural Placement

Study Overview
=================
Brief Summary
-----------------
Specific Aim: The purpose of this study is to determine if labor epidural placement using real-time (concurrent) ultrasound guided placement is superior to the conventional standard epidural technique without the use of ultrasound at Magee-Womens Hospital. Hypothesis: Ultrasound guided labor epidural placement in real-time will decrease the traditional epidural failure rate from 5% to 1%.

Official Title
-----------------
Real-time Ultrasound Guided Labor Epidural Placement

Conditions
-----------------
Epidural Anesthesia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All pregnant women of childbearing age (including children aged 14 years and above) who request epidural analgesia at Magee-Womens Hospital will be eligible to participate in the study. Exclusion Criteria: Men will not be included.

Ages Eligible for Study
-----------------
Minimum Age: 14 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| US group<br>All patients admitted to the labor and delivery suite who request an epidural for labor analgesia. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Failed epidural placement rate |  | From admission untill delivery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The incidence of post dural puncture headache. |  | From insertion of epidural to 48 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
ultrasound, labor epidural, failed epidural, outcome, Epidural insertion under realtime ultrasound guidance
The Correlation Between MMCR and Phenylephrine Test

Study Overview
=================
Brief Summary
-----------------
The propose of the study is the examine the association between the amount that the eyelid rise 3 months after surgery and the reaction to Efrin test before surgery

Official Title
-----------------
The Correlation Between Müller's Muscle-Conjunctival Resection and Phenylephrine Test

Conditions
-----------------
the Correlation Between Erin Test and Müller's Muscle-Conjunctival Resection

Intervention / Treatment
-----------------
* Drug: Efrin drops


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with ptosis patients that react to Efrin test Exclusion Criteria: Other eye diseases other eye surgeries

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Good reaction to Efrin test<br> | Drug: Efrin drops<br>* The amount that the eyelid rise after Erin drops before surgery<br>|
| Unsatisfied reaction to Efrin test<br> | Drug: Efrin drops<br>* The amount that the eyelid rise after Erin drops before surgery<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The reaction to efrin test before surgery |  | 15 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The amount that the eyelid rise after surgery |  | 3 MONTHS postoperatively |
Pubourethral Ligament Plication for the Surgical Treatment of Stress Urinary Incontinence

Study Overview
=================
Brief Summary
-----------------
To test efficacy and safety at six months of the proposed Pubourethral Plication Procedure (PPP) for cure of stress urinary incontinence - reinforcing pubourethral ligaments (PUL) with large diameter polyester sutures.

Detailed Description
-----------------
Full thickness vaginal incisions will be made in the suburethral sulci extending from bladder neck to urethral meatus. The operation space is 2.5cm2 space. A No2 or 3 polyester suture will be inserted into PUL, immediately lateral to midurethra, into PUL origin, external urethral ligament, laterally into m.pubococcygeus, then will be tied, but not tightly. The vaginal incisions will be closed with vicryl sutures. All women will be discharged on day of surgery. During the regular follow ups the healing at stress urinary incontinence will be evaluated

Official Title
-----------------
Pubourethral Plication Procedure (PPP) Cures Stress Urinary Incontinence Without Tapes- First Report.

Conditions
-----------------
Urinary Incontinence, Pelvic Floor Disorders

Intervention / Treatment
-----------------
* Other: Polyester suture


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Urine loss on coughing controlled by hemostat behind symphysis Exclusion Criteria: No exclusion criteria

Ages Eligible for Study
-----------------
Minimum Age: 25 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Polyester suture arm<br>A No 3 polyester suture will be inserted into the external urethral ligament, into the uurethral part of pubourethral ligament and into the pubic part of the pubourethral lgament then will be tied, but not tightly. The interventions will be carried on either side of the urethra that will be opened up by an 2.5 cm incision in the periurethral sulci. | Other: Polyester suture<br>* A No2 polyester suture will be used for tying special anatomical structures fr telieving the symptom. of stress urinary incontinence<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Curing effect of the suturation | The plication of pubourethral ligaments with a polyester suture will lead to a neoligament formation; so that the pubourethral ligaments will get strenghened. If the pubourethral ligaments get strengthened woman will not loose urine upon stressful activities such as coughing. Hence the stress test will be negative. And the rate of negative stress test within the cohort will show us the efficinecy of operation in curing urinary incontinence | 6 months |
Vesair Continued Access Trial

Study Overview
=================
Brief Summary
-----------------
Single arm study of the Vesair Balloon in postmenopausal women.

Detailed Description
-----------------
All women enrolled will be treated with the vesair balloon and followed for a maximum of 3 years, with balloon replacement annually.

Official Title
-----------------
Vesair Continued Access Trial: Use of the Vesair® Bladder Control System in the Treatment of Post-Menopausal Female Subjects With Stress Urinary Incontinence

Conditions
-----------------
Stress Urinary Incontinence

Intervention / Treatment
-----------------
* Device: Vesair Bladder Control System


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Post-menopausal women with SUI or stress predominant mixed incontinence Maximum score on IQOL of 60 Positive cough test for leakage Willing to undergo procedures Free from infection Have previously tried (and failed) noninvasive treatment for SUI Exclusion Criteria: SUI due to SUI Urge-predominant mixed incontinence Incontinence of neurogenic etiology 2 or more UTIs in past year and 1 in past 3 months Surgery for SUI in the past 6 months taking medication that can be used to treat SUI taking medication that affects urinary symptoms for less than 3 months undergoing biofeedback Grade 3 or worse cystocele last menstrual period within 12 months oral progesterone or estrogen in the past 12 months BMI > 40 involuntary detrusor contractions or discomfort during bladder filling previous stage III or worse cancer previous cancer of the urinary tract previous symptoms for early stage cancer in the past 2 years anticoagulation therapy other than aspirin history of prosthetic heart valve neurological or connective tissue condition or disease affecting bladder function known allergy to device components

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: All women enrolled are treated.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Vesair Arm<br>Subjects treated with the Vesair Bladder Control System at enrollment. | Device: Vesair Bladder Control System<br>* Intravesical balloon<br>* Other names: Vesair Balloon;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improvement on patient-reported outcomes | Improvement reported on questionnaires | 3-12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reduction in leakage events | Reduction in leakage events reported on a voiding diary | 3-12 months |
Obtaining and Storing Human Blood, Urine, and Fecal Samples for Spirochete-Related Epidemiological Research

Study Overview
=================
Brief Summary
-----------------
Current spirochaete infection identification and diagnostic strategies have important limitations. Recent development may allow for an improvement in diagnostic, screening and survey capabilities. The goal of this study is to evaluate blood, urine and fecal samples from a variety of sources and generate information on the occurrence and epidemiology of spirochetes in the general and at risk populations.

Detailed Description
-----------------
The intent of this protocol is to obtain blood, feces and urine samples from subjects with or without a suspected spirochaete infection, so these samples can be used in spirochaete-related scientific studies.

Official Title
-----------------
Obtaining and Storing Human Blood, Urine, and Fecal Samples for Spirochete-Related Epidemiological Research

Conditions
-----------------
The Samples Will be Studied in Order to Attempt to Better Understand the Occurrence of Blood, Feces and Urine Borne Spirochaetes

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The subject must be able to be fully consented to the study. The subject must be 18 years of age or older. The subject must be mentally competent as determined by the Investigator. Exclusion Criteria: The subject must not be currently incarcerated or pregnant. The subject must not weigh less than 110lbs. If the subject will be contributing more that 60 ml of blood during an 8 (eight) week period, then the subject must not have donated red blood cells within the last 8 (eight) weeks. If the Subject's health would be compromised by contributing up to 30ml of peripheral blood. If in the opinion of the Investigator, the subject has any clinically significant medical diagnosis/conditions which would prevent participation.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
human blood, urine and fecal samples
Magnetic Resonance Imaging (MRI) Study of the Hippocampus After Infarction in the Territory of the Middle Cerebral Artery

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to observe delayed neuronal death of hippocampus after middle cerebral artery infarction in human beings.

Detailed Description
-----------------
40 patients with middle cerebral artery infarction and 40 healthy volunteers will be observed. All of them will receive MRI scan and the assessment of the neuropsychological function (MMSE, AVLT, HAMD) intending to observe delayed neuronal death of hippocampus after middle cerebral artery infarction in human beings.

Official Title
-----------------
To Observe Delayed Neuronal Death of Hippocampus After Middle Cerebral Artery Infarction Through Magnetic Resonance Imaging(MRI) Volume Measurement and Magnetic Resonance Spectroscopy(MRS) Study of Hippocampus

Conditions
-----------------
Ischemic Stroke

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical diagnosis of middle cerebral artery infarction At least six months from the stroke Must be able to measure his(her) neuropsychologic function (by MMSE, AVLT) Exclusion Criteria: Unable to undergo examinations due to disturbances of consciousness or medical conditions Severe dementia, apraxia, disturbances of sensation or perception Serious complications including severe heart failure, hepatic dysfunction, renal insufficiency,or shock Parkinson's disease, malignant tumor, autoimmune diseases
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>chronic-stage patients after infarction in the territory of unilateral middle cerebral artery | |
| 2<br>age, sex and risk factor matched volunteers without ischemic stroke | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
middle cerebral artery, infarction, chronic stage, hippocampal volume, MRI, MRS, neuropsychologic assessment
Screening for Atherotic Plaques by Ultrasound for Assessing Cardiovascular Risk

Study Overview
=================
Brief Summary
-----------------
Cardiovascular disease is a common diagnosed and treated condition in private practices of primary health care. There is growing evidence that atherosclerotic plaques as predictors for stroke and heart attack are more prevalent than expected based on the clinical score in people with low risk for stroke and heart attack . Diagnosing atherosclerotic plaques can help to decide if a lipid lowering therapy should be prescribed even if the clinical risk score is low or on the other hand if they can be observed even in high lipid levels.

Detailed Description
-----------------
Both common and proximal internal carotid arteries and both common femoral arteries (including bifurcations) were screened by ultrasound in patients who came for a check-up to a primary care practice with no known cardiovascular disease and low risk for stroke and heart attack according to the AGLA/GSLA risk score which is mostly used in Switzerland. All patients agreed and gave written informed consent to be included in this study. Presence of plaques was defined as a focal carotid intima-media thickness >0.5 cm on ultrasound. Screening was performed by a medical doctor (DP) certified for the procedure using the following ultrasound system: Toshiba Nemio XG, probe 7.5 MhZ.

Official Title
-----------------
Prevalence of Atherosclerotic Carotid and/or Femoral Plaques in Patients Without Known Cardiovascular Disease and at Low-risk for Major Cardiovascular Events (AGLA/GLSA Score) Visiting a Private Primary Healthcare Practice in Switzerland

Conditions
-----------------
Atherosclerosis of Artery

Intervention / Treatment
-----------------
* Diagnostic Test: ultrasound guided detection of atherosclerotic plaques


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: low cardiovascular risk assessed by the AGLA/GSLA-score Exclusion Criteria: cardiovascular disease

Ages Eligible for Study
-----------------
Minimum Age: 41 Years
Maximum Age: 72 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: ultrasound guided detection of atherosclerotic plaques|screening by ultrasound of atherosclerotic plaques|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of plaques in cardiovascular low risk population | Number of participants with the presence of carotid and/or femoral atherosclerotic plaques diagnosed via ultrasound (defined as a focal intima-media thickness >0.5 cm on ultrasound). | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
plaques detection by ultrasound
Fragility and Programmed Cardiovascular Surgery (EcoSarco)

Study Overview
=================
Brief Summary
-----------------
Objectives: To characterize textural ultrasonographic biomarkers of the brachial biceps musculature, wrist flexors, quadriceps and anterior tibial muscle that allow the recognition of the muscular and functional status of patients undergoing programmed cardiovascular surgery and relate them to mortality, hospital stay and functionality results after the intervention. Design: A first phase of cross-sectional observational study and a second phase of longitudinal observational prospective study. Participants: Patients with programmed cardiovascular surgery to aortic valve replacement Outcomes: Sociodemographic and anthropometric variables, severity and clinical risk scales, disability, fragility and quality of life scales, nutritional status and textural muscular biomarkers with ultrasonography. Expected results: strong association between ultrasound muscle biomarkers and ICU and hospital stay, disability, fragility and quality of life after the surgery.

Official Title
-----------------
Fragility and Programmed Cardiovascular Surgery: Development of Muscle Ultrasonographic Biomarkers of Sarcopenia and Post-surgical Results

Conditions
-----------------
Fragility, Intensive Care Unit Syndrome

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Waiting list patients with cardiovascular surgery scheduled for aortic valve refill Exclusion Criteria: Urgency while waiting list Patients with no evaluation by presurgery committee Previous diagnosis of neuropathies, radiculopathy, polyneuropathy congenital or acquired or pathologies with muscular affectation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in muscle ultrasonography variation after surgery | Ultrasonography variation is a measure of the degree of heterogeneity of a ultrasonographic image which provides information on changes in tissue structure (muscles). | 6 months | 
| Changes in muscle echointensity after surgery | Echointensity is the average of echogenicity of a ultrasonographic image which provides information on changes in tissue structure | 6 months | 
| Changes in muscle texture after surgery | Muscle texture can be characterized by advanced image analysis algorithms such grey level co-occurrence matrices. In this case 5 textural parameters (uniformity, contrast, homogeneity, correlation and entropy) used together are used to characterize the tissue. | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Imaging biomarkers, Ultrasonography, Fragility, Intensive Care Unit