Studying the Influence of Exposure to Maternal Voice on Oral Feeding Volumes in Preterm Infants

Study Overview
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Brief Summary
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Oral feeding is one of the primary functions of the neonatal brain. In preterm infant population, competency at oral feeding is one of the major milestones in preparation for discharge. Mother's voices have been shown to have a net stimulatory effect and premature infants have been found to have increased cardiorespiratory stability after listening to mother's voices. Main objective of this study is to determine if it is possible to expose preterm infant in a systematic manner to mother's voices before their feeds and to determine if this exposure results in an increase in their oral intake.

Detailed Description
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Achievement of full oral feedings is directly associated with length of neonatal intensive care unit stay. Extremely low gestational age infants with dysfunctional oral feeding in early childhood have lower cognitive and language skills compared with those with normal oral feedings. Also, previous studies have shown a strong association between oral feeding and infant maturity and behavior state and positive feeding experience. In recent years, there is emerging evidence that non-medical developmental care interventions in the neonatal intensive care units such as kangaroo care, single family rooms, and music and massage therapy may be beneficial for preterm infants and improve their long term neurodevelopmental outcomes. Beneficial effects of exposure to mother's voice and sounds on preterm infants in the neonatal intensive care units are well documented. Our study proposes to examine the association between exposure to mother's voice prior to and during oral feeding and oral feeding volume and rate in preterm infants.

Official Title
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Studying the Influence of Exposure to Maternal Voice on Oral Feeding Volumes in Preterm Infants

Conditions
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Enteral Feeding

Intervention / Treatment
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* Behavioral: Maternal Voice Exposure


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Preterm infants born between gestational age of 28 0/7 weeks and 34 6/7 weeks Ready to start oral feeding attempts Taking a total daily oral intake < 50% of feeds on average in 2 days prior to starting intervention Mothers who are English speaking and over 18 years old Exclusion Criteria: Major congenital anomalies Non-English speaking Family history of suspected congenital hearing loss Failed hearing test in NICU Grade three to four intraventricular hemorrhage or periventricular leukomalacia necrotizing enterocolitis requiring treatment Congenital infections such as cytomegalovirus which can lead to sensorineural hearing loss

Ages Eligible for Study
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Minimum Age: 28 Weeks
Maximum Age: 40 Weeks

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Maternal Voice Exposure<br>Infants enrolled will be exposed to maternal voice for 20 min immediately prior to being offered oral feedings. This exposure will be conducted 2 times a day until infant starts taking all enteral feeds orally. | Behavioral: Maternal Voice Exposure<br>* Main objective of this study is to determine if it is possible to expose preterm infant in a systematic manner to mother's voices before their feeds and to determine if this exposure results in an increase in their oral intake.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Oral feeding volume | Effect of maternal voice immediately prior to feeding on oral feeding volumes in preterm infants | Through study completion, average 40 weeks post menstrual age | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Maternal Voice