Impact of Hemiplegia Due to Stroke on the Microarchitecture of the Bone

Study Overview
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Brief Summary
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In hemiplegic, there is very little data on the impact of neurological deficit on the microarchitecture independent of bone mineral density and composition of the bone marrow. Rare studies have shown the relationship between some micro-architectural parameters and severity of neurological deficit. There is no study in humans on the evolution of the parameters of the microarchitecture assessed by 3D micro-tomography in the early phase of the installation of neurological deficits after stroke, in terms of a bearing bone, tibia, that a non-load bearing bones, radius.

Detailed Description
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Each patient must answer several questionnaires about their calcium intake and its ability to perform everyday tasks. They will also have 3 blood samples (15 ml each time), 3 measure of bone by 3D micro-tomography and 2 MRI examination. These examinations and sampling will take place after 30 days after stroke onset (except for MRI) and again after three months and six months after the stroke (the same day as the medical follow-up visit).

Official Title
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Impact of Hemiplegia Due to Stroke on the Microarchitecture of the Bone: Evaluation Using Micro CT 3D High Resolution and by Magnetic Resonance Imaging (MRI)

Conditions
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Stroke, Hemiplegia

Intervention / Treatment
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* Procedure: MRI and 3D CT scan


Participation Criteria
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Eligibility Criteria
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Inclusion criteria at least 30 years vascular hemiplegia National Institute of Health Stroke Score equal 4 or greater with a motor of upper limb score greater than or equal 2 and a motor score of greater than or equal legs 2 Exclusion criteria Concomitant bone disease Endocrinopathies Phasic disorders understanding Contra-indication to MRI

Ages Eligible for Study
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Minimum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients<br>Patients who have experienced a vascular hemiplegia and accept bone measure by MRI and 3D CT scan | Procedure: MRI and 3D CT scan<br>* Measurement of bone microarchitecture at the legs and wrists by 3D CT Scan and measuring the proportion of fat in the imaging leg bone (MRI)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bone volume / tissue volume | Measure of Bone volume / tissue volume by the 3D CT scan | 90 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bone volume / tissue volume | Measure of Bone volume / tissue volume by the 3D CT scan | 1 day | 
| intraosseous fat | Measure the percentage of the intraosseous fat by MRI | 90 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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bone microarchitecture, hemiplegia