Parental Consanguinity and Family History of Kidney Disease in Turkish Kidney Disease Population

Study Overview
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Brief Summary
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Inbreeding and consanguineous marriages are known to increase the risk of autosomal recessive disorders. The aim of this study was to examine the association between consanguinity and kidney diseases in the adult Turkish population.

Detailed Description
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This was a national, cross-sectional study recruiting patients from nephrology out-patient clinics and dialysis units. All patients between 18 and 70 years of age who were on follow up in outpatient clinic and dialysis unit at the Istanbul Medical Faculty from October 2009 to October 2015 were included in the study. All patients and healthy controls enrolled in this study gave informed consent to participate in the survey. They were all asked to answer a questionnaire including socio-demographic data, history of familial kidney disease and consanguineous marriage. Additional information was obtained from their private physicians and medical files. To ensure reliability of administration of the questionnaire, all interviewers underwent training using a standardized protocol.

Official Title
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The Importance of Parental Consanguinity and Family History of Kidney Disease in Turkish Adult Chronic Kidney Disease Population

Conditions
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Hereditary Diseases

Intervention / Treatment
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* Other: Patients


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: follow up in outpatient clinic and dialysis unit at the Istanbul Medical Faculty between 18-70 years old provide informed consent Exclusion Criteria: follow-up shorter than 6 months patients whose data were not available patients who were unwilling or unable to provide informed consent

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients<br>Patients who have chronic kidney diseases | Other: Patients<br>* In this study we aimed to investigate effect of family history and consanguineous marriage in the development of CKD in the adult Turkish population.<br>* Other names: Inbreeding marriage;|
| Healthy controls<br>Healthy subjects | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect of parental consanguinity on chronic kidney disease confirmed by a questionnaire did they have consanguinity marriage or not. |  | 6 months after enrollment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect of family history of kidney disease on the development of chronic kidney confirmed by a questionnaire did they have any parents with chronic kidney diseases or not. |  | 6 months after enrollment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Consanguinity-associated kidney diseases, Turkey population