Doxazosin Effects on ABPM in Hypertensive Patients With Diabetic Nephropathy

Study Overview
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Brief Summary
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Few studies have reported the effect of alpha1-adrenergic antagonists on 24-h blood pressure and regulation of sympathetic nervous activity in hypertensive patients with diabetic nephropathy. Using ambulatory blood pressure monitoring devices equipped with spectral analysis of heart rate variability, we assess the effects of doxazosin on blood pressure in diabetic nephropathy patients and compare the results with those in patients with essential hypertension, patients with diabetes mellitus and patients with chronic nephropathy.

Detailed Description
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The study is an open-labeled parallel prospective trial comparing the effects of doxazosin (2-8 mg/day) on 24-h blood pressure and autonomic nervous activity. Hypertensive patients with non-insulin-dependent diabetic nephropathy, patients with essential hypertension, patients with diabetes mellitus and patients with chronic nephropathy undergo ambulatory blood pressure monitoring before and after treatment with doxazosin. Simultaneously, spectral analysis is performed to calculate the high frequency components as a marker of parasympathetic nervous activity, and the low frequency components/high frequency components ratios as an index of the sympathovagal balance.

Official Title
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Effects of Doxazosin on Ambulatory Blood Pressure and Sympathetic Nervous Activity in Hypertensive Patients With Diabetic Nephropathy

Conditions
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Diabetes Mellitus, Essential Hypertension, Renal Failure

Intervention / Treatment
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* Drug: Effects of doxazosin on morning surge in diabetic patients


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Hypertensive patients with diabetes mellitus Hypertensive patients Hypertensive patients with renal disease Exclusion Criteria: Cardiac, hematologic or hepatic disease Renal insufficiency (serum creatinine values> 2 mg/L) Hormone-induced hypertension Cerebral infarction or hemorrhage Other major diseases

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 79 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Effects of doxazosin on morning surge in diabetic patients|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Normalization of high blood pressure |  | One year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ambulatory blood pressure monitoring, doxazosin, alpha1-adrenergic antagonists, sympathetic nervous activity, diabetic nephropathy, essential hypertension, power spectral analysis, morning surge