Physiological Response and Visual Attention to Visual Food Images in Healthy Subjects and in Functional Dyspepsia Patients

Study Overview
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Brief Summary
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In functional dyspepsia (FD), abnormal cognitive and emotional changes such increased sensitization, anxiety, and depression scores have been reported in addition to the peripheral changes in gastrointestinal tract functions. In this study, investigators will evaluate the activity of autonomic nervous system, emotional response, and visual attention to food and non-food images in 30 male and female FD patients and 30 age/gender-matched healthy volunteers. These data will provide a new finding of the influence of impaired cognitive processing of food on symptom generation in functional gastrointestinal disorder patients.

Conditions
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Functional Dyspepsia

Intervention / Treatment
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* Behavioral: visual images


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male and female, volunteering adults BMI: 18-25 kg/m² right-handed Age: 18-65 years Capacity to give informed consent For FD patients, Diagnosis of functional dyspepsia over the last 12 months certified by a medical record Inconspicuous gastroscopy during the last 6 months certified by a medical record Exclusion Criteria: Visual impairment Severe psychiatric illness (e.g. schizophrenia, severe depression (BDI-II:29-63)), substance dependence and abuse Intake of antidepressants / antipsychotics

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Functional dyspepsia patient<br>Visual stimuli of food and non-food images will be presented to patients. Non-food images include positive, neutral, negative emotional pictures. | Behavioral: visual images<br> <br> |
| Experimental: Healthy<br>Visual stimuli of food and non-food images will be presented to participants. Non-food images include positive, neutral, negative emotional pictures. | Behavioral: visual images<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Psychological response | Skin conductance response | 1-2 years | 
| Psychological response | heart rate variability | 1-2 years | 
| Psychological response | facial muscle contraction | 1-2 years | 
| visual attention | eyemovement | 1-2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Subjective rating | fullness (visual analog scale) | 1-2 years | 
| Subjective rating | satiation (visual analog scale) | 1-2 years | 
| Subjective rating | nausea (visual analog scale) | 1-2 years | 
| Subjective rating | pain (visual analog scale) | 1-2 years | 
| Subjective rating | mood (visual analog scale) | 1-2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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skin conductance response, facial muscle activity, heart rate variability, eyetracking