Nitrous Oxide On Acute Postoperative Pain and Opioid Consumption and Chronic Pain After Inguinal Hernia Repair Surgery

Study Overview
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Brief Summary
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To compare postoperative pain, opioid consumption and chronic pain in patients undergoing to hernia repair surgery after receiving nitrous oxide or oxygen during the general anesthesia.

Detailed Description
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The study is prospective and double blind. In the clinic, patients undergoing inguinal hernia surgery that meet the criteria for inclusion into the study and agreed to participate in the study will be randomized into two groups. In the first group of patients will receive Nitrous Oxide and In the second group of patients will receive oxygen during the general anesthesia.

Official Title
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Effect Nitrous Oxide On Acute Postoperative Pain and Opioid Consumption and Chronic Pain After Inguinal Hernia Repair Surgery

Conditions
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Inguinal Hernia Repair, Post Operative Pain

Intervention / Treatment
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* Drug: Nitrous Oxide
* Other: oxygen


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 to 65 years old at time of the first procedure American Society of Anesthesiologists physical status I or II Inguinal hernia repair surgery undergoing the general anesthesia Exclusion Criteria: Neuropathic disease Chronic opioid users Contraindication for Nitrous Oxide receive Consent will not be obtained patient Psychiatric disorders Current or recent drug abuse (within past 6 months).

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Nitrous oxide<br>Subjects will receive General anesthesia with Nitrous Oxide. | Drug: Nitrous Oxide<br>* Nitrous Oxide, 70%, O2 30%) 1-5 L, Sevoflurane 1-2%, ETCO2: 32-35 mmHg.<br>|
| Placebo Comparator: Oxygen<br>Subjects will receive General anesthesia with oxygen. | Other: oxygen<br>* Subjects will receive General anesthesia: (Air, 70%, O2 30%) 1-5 L, Sevoflurane 1-2%, ETCO2: 32-35 mmHg.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nitrous oxide and chronic pain | The effect of 70% N20/30% O2 on post inguinal hernia repair procedure in prevention of chronic pain. | 30 days post operative | 
| Nitrous oxide and opioid consumption | The effect of 70% N20/30% O2 on post inguinal hernia repair procedure in decrease in opioid consumption. | 4 hours after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| smoking and post operative pain | The effect of active smoking to increase post operative acute pain. | 4 hours after surgery | 
| smoking and chronic pain | The effect of active smoking and chronic pain | 30 days post operative |