A Retrospective Study on Laser Treatment of Nevus of Ota in Thai Patients

Study Overview
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Brief Summary
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A retrospective study on efficacy and complication of laser treatment (Q-switched Nd:YAG and picosecond laser) of nevus of Ota in Thai patients

Detailed Description
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Nevus of Ota is a benign dermal melanocytic nevus found most commonly in Asians. About 50-60% of all cases have the age of onset at birth or within the first year of life, others appear before puberty. It typically presents as a unilateral mottled blue-gray macules and patches distributed along the first and second branches of trigeminal nerve. Due to its marked hyperpigmentation on the face which does not resolved spontaneously, patients may experience psychosocial disturbances and often seek for treatments. Based on selective photothermolysis theory, Q-switched lasers (ruby 694nm, alexandrite 755nm, Nd:YAG 1064nm) have been used for the treatment of nevus of Ota with a success rate of 95% after 6-8 sessions. Reported complications from the lasers are hypopigmentation(15.3%), hyperpigmentation(2.9%), texture changes (2.9%), and scarring (1.9%). Siriraj Skin Laser Center provides laser treatment for nevus of Ota using mainly Q-switched Nd:YAG laser and Picosecond laser. The study of efficacy and complications of Q-switched Nd:YAG and Picosecond laser in the treatment of Nevus of Ota in Thai patients has never been reported. Therefore, we conduct a retrospective study on efficacy and complication of laser treatment (Q-switched Nd:YAG and picosecond laser) of nevus of Ota in Thai patients.

Official Title
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A Retrospective Study on Laser Treatment of Nevus of Ota in Thai Patients

Conditions
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Focus on Laser Treatment of Nevus of Ota in Thai Patients

Intervention / Treatment
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* Other: Laser (QS, Picosecond laser)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient with Nevus of Ota Complete data between January 2008 - December 2018 Exclusion Criteria: Incomplete data
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients with nevus of Ota<br>patients with nevus of Ota who had been treated with laser at Siriraj hospital | Other: Laser (QS, Picosecond laser)<br>* QS-Nd Yag Laser, Picosecond laser<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Efficacy of laser treatment in paitients with Nevus of Ota | Fading of lesions after treatment by chart review | 2008-2018 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complication of laser such as hyperpigmentation, hypopigmentation, and scars | Complication of laser such as hyperpigmentation, hypopigmentation, and scars | 2008-2018 | 
| Relapse rate after laser treatment | rate of recurrence after treatment | 2008-2018 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Nevus of Ota, laser treatment, Thai