The Effects of Continuous Positive Airway Pressure on Overlap Syndrome

Study Overview
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Brief Summary
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The first objective of this study is to determine the differences between, while the airway obstruction severity is the same, and the acute continuous positive airway pressure (CPAP) effect on chronic obstructive pulmonary disease (COPD) patients with overlap syndrome compared with COPD patients without in terms of sleep quality, autonomic nerve activity, biologic markers of systemic inflammatory, and exercise performance. The second objective of this study is to evaluate the subacute (3 months treatment) CPAP effect on COPD patients with overlap syndrome in terms of pulmonary hemodynamic and right heart function, We will also determine the subacute effect of CPAP on sleep and life quality, autonomic nerve activity, biologic markers of systemic inflammatory, as well as exercise performance. The last objective of this study is to evaluate the long term (12 months treatment) CPAP effect on COPD patients with overlap syndrome. The un-scheduled clinic or emergency department visiting, hospitalization, or mortality will be recorded to see if there is significant treatment effect in terms of reducing morbidity and mortality. The long term CPAP effect on sleep and life quality, autonomic nerve activity, biologic markers of systemic inflammatory, exercise performance, as well as pulmonary hemodynamic and right heart function will be re-evaluation.

Detailed Description
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COPD patients will be disturbed by season 12 months follow up is better than 18 months

Official Title
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The Continuous Positive Airway Pressure Effects on Chronic Obstructive Pulmonary Disease Patients With Obstructive Sleep Apnea

Conditions
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COPD & OSA

Intervention / Treatment
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* Device: continuous positive airway pressure


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: chronic stable COPD FEV1/FVC < 70% No response to beta-agonist without acute exacerbation within2 months Exclusion Criteria: Chronic respiratory failure (PaO2<60 mmHg, PaCO2>50 mmHg) Clinical evidence of congestive heart failure Facial defect and all the other condition that can't tolerate nasal mask Malignancy

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COPD with OSA with CPAP treatment<br>COPD with OSA: CPAP treatment | Device: continuous positive airway pressure<br>* CPAP with adequate pressure for 1 day, 3 & 12 months<br>|
| COPD without OSA<br>COPD without OSA, not treat with CPAP | |
| COPD with OSA but without CPAP treatment<br>COPD with OSA but patient refused CPAP treatment | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| exercise performance | the condition of COPD patient will be disturbed by season factor 12 months follow up will be better than 18 months | 3 days, 3 & 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| autonomic nerve activity | the same reason as above | 3 days, 3 & 12 months | 
| mortality and acute exacerbation |  | 1, 5, 10 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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chronic obstructive airway disease, obstructive sleep apnea, continuous positive airway pressure