The Cardiac Effects of Prolonged Hypothermia After Cardiac Arrest

Study Overview
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Brief Summary
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This PhD study is a sub study in a randomized clinical controlled multicenter trial named TTH48 (ClinicalTrials.gov Identifier: NCT01689077). The TTH48 trial examines prolonged mild therapeutic hypothermia (MTH) at 32-34°C in 24 versus 48 hours with the primary outcome Cerebral Performance Category after 6 month in comatose out-of-hospital cardiac arrest patients. THE OVERALL AIM OF THIS PhD STUDY IS TO INVESTIGATE THE CARDIAC FUNCTION AND THE HEMODYNAMICS BY BIOCHEMICAL CARDIAC MARKERS, ECHOCARDIOGRAPHY, BY ANALYZING THE USAGE OF INOTROPES/VASOPRESSORS AND BY ANALYZING ECG DATA FOR ARRHYTHMIAS IN THE 24 VERSUS 48 HOURS MTH GROUPS.

Detailed Description
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The PhD-study contains 3 sub studies: Study 1 estimates the extend of myocardial damage resulting from the primary arrest and from the reperfusion injuries: Area under the curve of cTnT and CK-MB as 12 repeated measurements and NT-proBNP as 4 measurements post arrest -Hypothesis: There is a statistically significantly greater release of the cardiac biomarkers cTnT and NT-proBNP quantified by the area under the curve in the 24 versus the 48 hours group in the intervention period from 24 to 72 hours. Study 2 investigates MTH´s influence on systolic and diastolic function by standard and Tissue Doppler (TDI) echocardiography after 24, 48 and 72 hours. The primary endpoint is mitral annular systolic velocity (S´ max) -Primary hypothesis: There is statistically significant improvement in S' max from the time T24 to T72 in the 48 versus the 24 hours group. -Secondary hypothesis: There is statistically significantly better systolic function at T48 measured in terms of individual S' max-change in the 48 hours group (still hypothermic) versus the 24 hours group (reached normothermia). Study 3 investigates MTH´s influence on the need for vasopressor or inotrope and the duration of arrhythmias during the first 72 hours post arrest. Primary hypothesis: There is a statistically significantly increased tendency of arrhythmias in the 48 versus the 24 hours group measured in the period from T0 to T72. Secondary hypothesis: There is a statistically significantly reduced need for inotropes in the 48 versus the 24 hours group measured by cumulative vasopressor index in the period from T0 to T72.

Official Title
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The Cardiac Effects of Prolonged Hypothermia After Cardiac Arrest

Conditions
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Cardiac Arrest, Hypothermia

Intervention / Treatment
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* Procedure: Mild therapeutic hypothermia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Resuscitated after cardiac arrest outside hospital with suspected cardiac triggering cause (and stabile circulation for at least 20 minutes after return of spontaneous circulation, Glasgow coma score < 8 and Age ≥ 18 years and < 80 years. Exclusion Criteria: Cardiac arrest of suspected non-cardiac triggering cause (e.g. trauma, aortic dissection, massive bleeding, hypoxia or accidental hypothermia), >60 minutes from cardiac arrest to ROSC, Time from cardiac arrest until start of cooling >4 hours, Terminal illness, Coagulopathy (medical anticoagulation treatment including thrombolysis is not a contraindication), Unwitnessed arrests with asystolia as presenting rhythm, Pregnancy, Persistent cardiogenic shock, Systolic blood pressure <80 mmHg despite vasoactive treatment and intra-aortic balloon pump CPC 3-4 before the cardiac arrest, Suspected/confirmed acute intra cerebral hemorrhage or stroke, Acute CABG or other operation in connection with performing CPR, Lack of consent from the relatives, Lack of consent from the GP and Lack of consent from the patient if he/she wakes up and is relevant.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 24 hours mild therapeutic hypothermia<br>The patient will be treated with mild therapeutic hypothermia for 24 hours after reaching the target temperature between 32-34°C. | Procedure: Mild therapeutic hypothermia<br>* Mild therapeutic hypothermia with a target temperature between 32-34°C.<br>|
| Experimental: 48 hours mild therapeutic hypothermia<br>The patient will be treated with mild therapeutic hypothermia for 48 hours after reaching the target temperature between 32-34°C. | Procedure: Mild therapeutic hypothermia<br>* Mild therapeutic hypothermia with a target temperature between 32-34°C.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Area under the curve cTnT | Allocated sub study 1 | In the intervention period from 24 to 72 hours | 
| Mitral annular systolic velocity | Allocated sub study 2 | After 24 hours, 48 hours and 72 hours | 
| Duration of arrhythmias | Allocated sub study 3 | From target temperature (32-34°C) has been reached until 72 hours after | 
| Cumulative vasopressor index | Allocated sub study 3 | From target temperature (32-34°C) has been reached until 72 hours after | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Area under the curve NT-proBNP | Allocated sub study 1 | In the intervention period from 24 to 72 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cardiac arrest, Therapeutic Hypothermia, Cardioprotectiveness, Hemodynamics