Multicenter Comparative Study of the Activity of the Medial Prefrontal Cortex in Vulnerability to Depression

Study Overview
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Brief Summary
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To examine whether the medial prefrontal cortex displays an increased activity during self-referential processing among remitted depressed patients compared to healthy controls

Official Title
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Medial Prefrontal Cortex and Vulnerability for Depression

Conditions
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Major Depression

Participation Criteria
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Eligibility Criteria
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Inclusion criteria (patients) History of at least one major depressive episode In clinical remission for at least 6 months (BDI-21 ≤ 10 & Montgomery and Asberg Depression Rating Scale ≤ 7) Aged 20-65 Exclusion criteria : first depressive episode after the age of 59 last episode treated by cognitive behavior therapy currently receiving a antipsychotic or mood-stabilizing drug personal history of: major depressive episode with psychotic features, other axis-I disorder (except generalized anxiety disorder), substance-related disorder (except nicotine dependence), bipolar disorder first-degree familial history of bipolar disorder cognitive impairment due to another central nervous system disease contra-indication to MRI pregnancy refusal to be informed of abnormal findings during the MRI

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Remitted depressed patients<br>Formerly depressed patients in remission for 6 months or more | |
| healthy controls<br>healthy subjects with no history of mental disorders | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| BOLD signal in the medial prefrontal cortex | Each subject will have a standardized psychometric assessment (BDI-21, MADRS, STAI, RRS) in a Siemens 3T Trio for collecting voxel BOLD signal (Blood-Oxygen-Level Dependent). For each subject and each voxel, a coefficient beta relative activation will be obtained with a general linear model using the timing of presentation of stimuli and the expected signal to model the measured hemodynamic BOLD response. A main effect of condition (personal versus general) will be sought to determine the peak activation within the dorsal CMPF (defined region of interest using the Pickatlas software). The primary endpoint will be the beta coefficient on the level of activation of a sphere 10 mm in diameter centered on the peak. | 18 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| depression relapse | The presence (MINI) and intensity (BDI) for possible depressive relapse will be sought from the attending psychiatrist and during telephone interviews at 6 and 12 months. | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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depression