Resistance Training in Patients With Chronic Obstructive Lung Disease (COPD): Whole Body Vibration Versus Conventional Resistance Training

Study Overview
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Brief Summary
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Pulmonary rehabilitation has been emerged as a recommended standard of care for patients with chronic lung disease based on a growing body of scientific evidence. A set of evidence-based guidelines were published in American College of Chest Physicians (ACCP) and the American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR). Since then, the published literature in pulmonary rehabilitation has increased substantially, and other societies have published important statements about pulmonary rehabilitation (eg, the American Thoracic Society and the European Respiratory Society). In patients with COPD, there is a strong scientific basis for implementing conventional resistance training (CRT) in addition to endurance training. Endurance training, such as walking, is a key component of pulmonary rehabilitation and improves in exercise tolerance and muscular endurance. However, this type of training may not reverse muscle weakness or atrophy. For that reason, strength training seems to be the optimum training modality to increase muscle mass and strength. Recently, Whole-Body-Vibration (WBV) training has been promoted as an alternative for resistance training on multigym equipment. In WBV training, the subject stands on a platform that generates vertical sinusoidal vibration, during which static and dynamic exercises can be performed. The present study is conducted to provide an answer on the following question: will a resistance training program, such as the whole body vibration, be even effective than a conventional resistance training program in patients with COPD.

Official Title
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Resistance Training in Patients With Chronic Obstructive Lung Disease (COPD): Whole Body Vibration Versus Conventional Resistance Training

Conditions
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COPD

Intervention / Treatment
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* Behavioral: Conventional resistance training program
* Behavioral: Whole body vibration resistance training program


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with COPD candidate for pulmonary rehabilitation Men and female between 40 and 80 years of age Written informed consent to participate Exclusion Criteria: Severe cardiac, neurological and orthopedic co-morbidity interfering with exercise training. Pacemaker Hip, knee of shoulder prosthesis or recently introduced spirals, metal pens, bolts or plates Uncontrolled diabetes, epilepsy or migraine Osteoporotic or metastatic fractures, acute hernia, discopathy, spondylitis

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Conventional training<br> | Behavioral: Conventional resistance training program<br>* Conventional resistance training program is followed.<br>|
| Experimental: Whole body vibration training<br> | Behavioral: Whole body vibration resistance training program<br>* WBV training on FITVIBE<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| estimation of the change of 6 MWD before and after 12 weeks resistance training program (CRT versus WBV training) | estimation of the change of 6 MWD (submaximal walking test)after a 12 week conventional resistance training program or after a 12 week whole body vibration training program | before and after 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes in muscle strength (quadriceps force)after CRT or after WBV training in patients with COPD | measured by modified Microfet before and after 12 weeks of training. | before and after 12 weeks | 
| changes in body composition after CRT or after WBV training in patients with COPD | measured by bioelectrical impedance analysis: Fat Free Mass (FFM)before and after 12 weeks of training. | before and after 12 weeks | 
| changes in maximal exercise capacity after CRT or after WBV training in patients with COPD | measured by cyclo-ergospirometry before and after 12 weeks of training | before and after 12 weeks | 
| changes in muscle force after CRT or after WBV training in patients with COPD | measured by handgrip force, maximal inspiratory pressure (PImax) and maximal expiratory pressure (PEmax)before and after 12 weeks of training | before and after 12 weeks | 
| changes in Quality of life after CRT or after WBV training in patients with COPD | measured by CRDQ (Chronic Respiratory Disease Questionnaire)before and after 12 weeks of training | beforer and after 12 weeks | 
| changes in Dyspnea scores after CRT or after WBV training in patients with COPD | measured by Chronic Respiratory Disease Questionnaire domain dyspnea (CRDQd) and by the BORG scale before and after 12 weeks of training. | before and after 12 weeks | 
| changes in 6MWD and the endurance test on the bicycle after CRT or after WBV training in patients with COPD | measured by endurance test on the bicycle (75% Max. Workload)before and after 12 weeks of training. This test will also be repeated after 6 weeks of training. | before and after 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COPD, Whole Body Vibration training, Conventional resistance training