Non-contact DCS-Speckle Multi-parameter Imaging for Neurological Diseases

Study Overview
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Brief Summary
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This study aims to evaluate brain injuries and brain edema with non-contact DCS-Speckle multi-parameter imager.

Detailed Description
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Brain injuries includes acute and chronic injuries located in cerebral hemispheres, cerebellum, and brain stem, while brain edema is increased intracellular or extracellular fluid in brain tissue. Early diagnosis is helpful to improve the cure rate and reduce sequelae. This study aims to evaluate brain injuries and brain edema with non-contact DCS-Speckle multi-parameter imager, so as to provide reference diagnostic criteria by image artificial intelligence analysis.

Official Title
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Clinical Applications for Non-contact DCS-Speckle Multi-parameter Imaging for Brain Injuries and Brain Edema

Conditions
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Brain Injuries, Brain Edema, Optical Imaging

Intervention / Treatment
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* Diagnostic Test: Non-contact DCS-Speckle multi-parameter imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who have had brain damage. Patients who have had brain edema. Healthy people who are interested in non-contact DCS-Speckle multi-parameter imaging Exclusion Criteria: Patients who are in pregnancy or have plan to conception. Patients who have vertebra surgery or have plan to surgery. Patients who are inappropriate to join this trial judged by the radiologists or specialists. AIDS, Active Hepatitis, Tuberculosis, Syphilis Patients who regularly take anticoagulants, antiplatelet drugs
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Brain damage patients<br>Brain damage patients were monitored the human brain activity by the non-contact DCS-Speckle multi-parameter imager. | Diagnostic Test: Non-contact DCS-Speckle multi-parameter imaging<br>* The protocol consists of 2-min resting, 6-min stationary state and 2-min resting, with monitoring data continuously by the DCS-Speckle.<br>|
| Brain edema patients<br>Brain edema patients were monitored the human brain activity by the non-contact DCS-Speckle multi-parameter imager. | Diagnostic Test: Non-contact DCS-Speckle multi-parameter imaging<br>* The protocol consists of 2-min resting, 6-min stationary state and 2-min resting, with monitoring data continuously by the DCS-Speckle.<br>|
| Healthy subjects<br>Healthy subjects were monitored the human brain activity by the non-contact DCS-Speckle multi-parameter imager. | Diagnostic Test: Non-contact DCS-Speckle multi-parameter imaging<br>* The protocol consists of 2-min resting, 6-min stationary state and 2-min resting, with monitoring data continuously by the DCS-Speckle.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Imaging data | Imaging data collected during the non-contact DCS-Speckle imaging instrument | 1 day during the whole experiment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnostic report fMRI data | Patients' medical record and diagnostic report | 1 day during the whole experiment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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DCS-Speckle, Brain injuries, Brain edema