Concomitant Therapy of H. Pylori

Study Overview
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Brief Summary
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If we compare eradication rate of Helicobacter pylori divided to 4 groups: amoxicillin, rabeprazole, clarithromycin(AOC), amoxicillin, rabeprazole, metronidazole(AOM), treated with amoxicillin, rabeprazole for 5 day, followed by clarithromycin, metronidazole, rabeprazole for 5 days(sequential), amoxicillin, clarithromycin, metronidazole, rabeprazole(concomitant), then the eradication rate of concomitant group will be the highest.

Detailed Description
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Subject: The patient of gastritis, gastric ulcer, and duodenal ulcer infected with Helicobacter pylori 170 subjects per group Eradication regimens are as follows: AOC group, treated with amoxicillin, rabeprazole, clarithromycin for 7 days; AOM group, treated with amoxicillin, rabeprazole, metronidazole for 7 days; sequential group, treated with amoxicillin, rabeprazole for 5 day, followed by clarithromycin, metronidazole, rabeprazole for 5 days; concomitant group, treated with amoxicillin, clarithromycin, metronidazole, rabeprazole for 7 days

Official Title
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Evaluation of the Efficacy of Concomitant Therapy for Eradication of Helicobacter Pylori

Conditions
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Gastritis, Gastric Ulcer, and Duodenal Ulcer

Intervention / Treatment
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* Drug: amoxicillin, clarithromycin, metronidazole, rabeprazole


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients infected with Helicobacter pylori Exclusion Criteria: cancer pregnancy formerly treated with eradication

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: AOC group<br>AOC group: treated with amoxicillin, rabeprazole, clarithromycin for 7 days | Drug: amoxicillin, clarithromycin, metronidazole, rabeprazole<br> <br> * Other names: concomitant group: treated with amoxicillin, clarithromycin, metronidazole, rabeprazole for 7 days;|
| Experimental: AOM group<br>AOM group: treated with amoxicillin, rabeprazole, metronidazole for 7 days | Drug: amoxicillin, clarithromycin, metronidazole, rabeprazole<br> <br> * Other names: concomitant group: treated with amoxicillin, clarithromycin, metronidazole, rabeprazole for 7 days;|
| Experimental: Sequential group<br>Sequential group: treated with amoxicillin, rabeprazole for 5 day, followed by clarithromycin, metronidazole, rabeprazole for 5 days | Drug: amoxicillin, clarithromycin, metronidazole, rabeprazole<br> <br> * Other names: concomitant group: treated with amoxicillin, clarithromycin, metronidazole, rabeprazole for 7 days;|
| Experimental: concomitant group<br>concomitant group: treated with amoxicillin, clarithromycin, metronidazole, rabeprazole for 7 days | Drug: amoxicillin, clarithromycin, metronidazole, rabeprazole<br> <br> * Other names: concomitant group: treated with amoxicillin, clarithromycin, metronidazole, rabeprazole for 7 days;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of the efficacy of concomitant therapy for eradication of Helicobacter pylori | measure eradication rate of H.pylori with urea breath test(UBT) after 6 to 8 weeks of treatment | 6 months (Feb 2014) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Helicobacter, Eradication