Efficiency of Combined Rehabilitation Programs Including Resistance and Endurance Exercises on Functional Capacities, Quality of Life and Daily Level of Activities in Hemodialysis Patients

Study Overview
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Brief Summary
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Hemodialysis patients display among the lowest level of daily activities and decline of functional abilities is highly correlated with mortality. Perdialytic exercise during hemodialysis procedure is now part of the patients' routine care and appears to be a solution to struggle against the functional skills decrease. Our team was able to demonstrate that beyond muscle mass, muscle strength and physical activity were essential determinants of morbidity and mortality of dialysis patients. The AIDER Santé medical team has set up an assessment of physical activities and muscle strength in the Montpellier and Nimes centers. In order to rehabilitate muscle strength and endurance, perdialytic exercise may be prescribed. Its effectiveness can be appreciated by measuring the SPPB score (Short Physical Performance Battery). Recent studies established that combined training including resistance and endurance exercises was the most effective to improve functional performance. In AIDER Santé dialysis centers, the two mainly used exercise approaches are distinguished by the time distribution of the two types of exercise: the first plans to practice both types of exercise at each session (continuous program), the second plans to alternate a week of resistance exercise with a week of endurance exercise (discontinuous program). It is established that the rehabilitation of the hemodialysis patient must include both resistance and endurance exercises, but the combination of these exercises during the same session is potentially at the origin of an interference phenomenon, limiting neuromuscular adaptations specific to each effort. Therefore, the main hypothesis of the project is that the temporal separation of resistance and endurance exercises in a discontinuous program could optimize the functional gains of combined rehabilitation and therefore be more effective than a continuous program generating a phenomenon of interference.

Official Title
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Efficiency of Combined Rehabilitation Programs Including Resistance and Endurance Exercises on Functional Capacities, Quality of Life and Daily Level of Activities in Hemodialysis Patients: a Comparative Study of Current Practices.

Conditions
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Chronic Kidney Diseases, Hemodialysis, Physical Rehabilitation

Intervention / Treatment
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* Other: Combined rehabilitation during hemodialysis


Participation Criteria
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Eligibility Criteria
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Inclusion criteria: Hemodialysis started since at least 3 months Medical prescription of perdialytic combined exercise Age < 85 Life expectancy > 6 months Exclusion criteria: Ischemic and valvular cardiopathies Lower-extremity arterial disease (stade III and IV) Knee or hip amputation/prothesis Severe respiratory disease BMI > 35 Pacemaker

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Continuous<br>Continuous | Other: Combined rehabilitation during hemodialysis<br>* Combined rehabilitation during hemodialysis<br>|
| Discontinuous<br>Discontinuous | Other: Combined rehabilitation during hemodialysis<br>* Combined rehabilitation during hemodialysis<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Short Physical | Short Physical Performance Battery Score | Week 0, week 17 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Knee extension force | Knee extension force | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Perdialytic exercise, Combined rehabilitation, Functional abilities, Interference effect