Multiple Interactive With Nutrition and Exercise Strategies in Frailty Cancer Patients

Study Overview
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Brief Summary
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Due to the changes in lifestyle caused by the COVID-19, it is a priority to provide multi-interactive digital platforms and social media for nutrition and exercise programs for cancer patients. A two-year serial program uses mixed study methods of longitudinal combined experimental study. We will investigate cancer frailty's current situation and track the frailty trends after cancer patients received different treatments. We will also invite experts to develop multi-interactive digital platforms of nutrition and performance-based tailored circuit training programs according to the cancer frailty survey. We will recruit 20-85 years of newly diagnosed or first-time recurrence cancer patients and stratified randomization assigned to evaluate nutrition and physical exercise intervention effectiveness. The measure indicators were treatment-related adverse events, nutritional status, frailty status, survival rate, and life quality.

Official Title
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Department of Nursing, Tzu Chi University, Hualien, Taiwan

Conditions
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Cancer

Intervention / Treatment
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* Behavioral: Nutrition and Exercise Strategies


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged from 20-85 years with histological confirmation malignancy. Requiring treatment by surgery, chemotherapy, hormonotherapy, radiotherapy, or targeted therapy with a curative intention as estimated by oncologists. First diagnosed or recurrence of head and neck cancer, esophageal cancer, colon/rectum cancer, lung cancer, AML, ALL, lymphoma, multiple myeloma. Exclusion Criteria: Non-head and neck cancer, esophageal cancer, colon/rectum cancer, lung cancer, AML, ALL, lymphoma, multiple myeloma with first diagnosis or recurrence patients. Eastern Cooperative Oncology Group test score>2. Serious psychiatric or cognitive problems, and functional disability leading to a total inability to walk.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Factorial Assignment
Interventional Model Description: Arm A: fix model of cycle exercise(online supervise) and routine nutrition consult Arm B: fix model of cycle exercise(online supervise) and online nutrition consult Arm C: individualize cycle exercise(online supervise) and routine nutrition consult Arm D: individualize cycle exercise(online supervise) and online nutrition consult
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Arm A<br>fix model of cycle exercise(online supervise) and routine nutrition consult | Behavioral: Nutrition and Exercise Strategies<br>* Multiple Interactive with Nutrition and Exercise Strategies<br>|
| Experimental: Arm B<br>fix model of cycle exercise(online supervise) and online nutrition consult | Behavioral: Nutrition and Exercise Strategies<br>* Multiple Interactive with Nutrition and Exercise Strategies<br>|
| Experimental: Arm C<br>individualize cycle exercise(online supervise) and routine nutrition consult | Behavioral: Nutrition and Exercise Strategies<br>* Multiple Interactive with Nutrition and Exercise Strategies<br>|
| Experimental: Arm D<br>individualize cycle exercise(online supervise) and online nutrition consult | Behavioral: Nutrition and Exercise Strategies<br>* Multiple Interactive with Nutrition and Exercise Strategies<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Frailty trend | After treatment frailty condition | After treatment three-month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Treatment-related adverse events | CTCAE or Clavien-Dindo classification | After treatment one month |