Sildenafil in HFpEF (Heart Failure With Preserved Ejection Fraction) and PH

Study Overview
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Brief Summary
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Aim of the study is to investigate whether Sildenafil treatment results in a reduction of pulmonary artery pressure without decrease of cardiac output (CO) and in improvement of exercise capacity in patients with heart failure with preserved ejection fraction (HFpEF) with pulmonary hypertension ( PH).

Detailed Description
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Rationale: Treatment of diastolic left heart failure is a challenging task. Compared to systolic left heart failure the level of evidence for known medical treatment regiments is low. Sildenafil, a phosphodiesterase 5 (PDE 5) inhibitor and effective therapy for pulmonary arterial hypertension acts as a selective pulmonary vasodilator by inhibiting the impaired nitric oxide (NO) pathway. Reducing the pulmonary vascular resistance would be the primary target by treatment of diastolic left heart failure with PH. But clinical and hemodynamical studies to evaluate the role of Sildenafil in diastolic heart failure, also called heart failure with preserved ejection fraction (HFpEF) with secondary pulmonary hypertension are lacking. Our hypothesis is that Sildenafil decreases pulmonary artery pressure in patients with HFpEF and pulmonary hypertension. Objective: To investigate whether Sildenafil treatment results in a hemodynamic improvement and in an improvement of exercise capacity in these patients. Study design: single-center, prospective, randomized, placebo controlled study. Study population: 52 patients with HFpEF and PH Intervention : One group receives three times daily 20 mg Sildenafil for 2 weeks followed by three times daily 60 mg Sildenafil for 10 weeks. The other group receives three times daily 20 mg of Placebo, followed by 3 times daily 60 mg placebo. Main study parameters/endpoints: Primary objectives 1. To investigate whether Sildenafil treatment results in a reduction of pulmonary artery pressure (PAP) in HFpEF patients with PH (investigated invasively by right heart catheterization) . Secondary objectives To investigate whether Sildenafil treatment results in an reduction of wedge pressure in HFpEF patients. To investigate whether Sildenafil treatment results in an improvenemt of cardiac output (CO) in HFpEF patients. To investigate whether Sildenafil treatment results in improvement of exercise capacity in these patients ( defined as change in VO2max)

Official Title
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Effects of Sildenafil on Pulmonary Arterial Pressure in Patients With Heart Failure With Preserved Ejection Fraction ( HFpEF) and Pulmonary Hypertension

Conditions
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Heart Failure, Diastolic, Pulmonary Hypertension

Intervention / Treatment
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* Drug: Sildenafil
* Drug: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: >18 years Written inform consent PH secondary to diastolic left heart failure defined as PAP mean >25 mmHg Wedge mean >15 mmHg Normal systolic left ventricular (LV) function on echo/nuclear imaging (left ventricular ejection fraction (LVEF) > or =45%) New York Heart Association class (NYHA) II-IV despite heart failure therapy Exclusion Criteria: Severe noncardiac limitation to exercise (as severe chronic obstructive pulmonary disease) Other cause of PH besides diastolic heart failure Coronary ischemia or recent myocardial infarction (<6 months) Hypotension ( <90/50 mmHg) Ongoing nitrate therapy Ongoing therapy with citochrome P450 3A4 ( CYP3A4) inhibitors (ketoconazole, erythromycin, cimetidine, clarithromycin, itraconazole, voriconazole and protease inhibitors) or CYP3A4 inductors(carbamacepine, phenytoin, phenobarbital, rifampicin, Sint Janskruid ). Furthermore patients will be informed not to drink grapefruit juice while on study medication because of the known impact of grape fruit on pharmacokinetics of Sildenafil. Ongoing therapy with alpha -inhibitors Significant mitral or aortic valve dysfunction Severe liver dysfunction Pregnancy Unable to read and comprehend Dutch language

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Sildenafil<br>Sildenafil orally 3 times 20mg for 2 weeks , followed by 3 times 60 mg for 10 weeks | Drug: Sildenafil<br>* Sildenafil administered orally 3 times per day 20 mg for the first 2 weeks, followed by 3 times 60 mg for 10 weeks<br>|
| Placebo Comparator: Placebo<br>placebo orally 3 times 20mg tablets, followed by 3 times 60 mg for 10 weeks | Drug: Placebo<br>* Placebo tablets 3 times per day 20 mg foor de first 2 weeks, followed by 3 times 60 mg for 10 weeks<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean Pulmonary Artery Pressure Measured by Right Heart Catheterization | change of mean pulmonary artery pressure between baseline and 12 weeks measured by heart catheterisation | baseline and 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| VO2max | difference in change of VO2 max between baseline and 12 weeks between Sildenafil and placebo group | baseline and 12 weeks | 
| Cardiac Output Measured Invasively by Right Heart Catheterization | difference in change of cardiac output between baseline and 12 weeks between Sildenafil and Placebo group | baseline and 12 weeks | 
| Wedge Pressure Measured Invasively by Right Heart Catheterization | Difference in change of wedge pressure between baseline and 12 weeks between Sildenafil group and Placebo group | baseline and 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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HFpEF, PH