Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion

Study Overview
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Brief Summary
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The effects colchicine administration for acute pericardial effusion after radiofrequency catheter ablation (RFCA) of atrial fibrillation on the recurrences of arrhythmia.

Detailed Description
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RFCA was started as a rhythm control of atrial fibrillation about 10 years before and the superiority of RFCA to medical treatment has been continuously reporting, so RFCA is globally performed nowadays. Acute pericardial effusion could occur during RFCA as complication, that might be developed to cardiac tamponade needed immediate pericardiocentesis. The inflammation developed after pericardiocentesis might be associated with the recurrences of atrial fibrillation, it could be presumed by the frequent occurrence of atrial fibrillation after open-heart surgery. The inflammation can be suppressed by administration of colchicine and the effects of colchicine have been proven to decrease the development of atrial fibrillation.

Official Title
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Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion Following Catheter Ablation of Atrial Fibrillation

Conditions
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Pericardial Effusion

Intervention / Treatment
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* Drug: Colchicine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients needed to pericardiocentesis during RFCA for paroxysmal or persistent atrial fibrillation. Exclusion Criteria: Hypersensitivity on Colchicine The existence of intra-cardiac thrombus on trans-esophageal echocardiography Pregnancy
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Colchicine<br>Impact of Colchicine therapy on arrhythmia Recurrence after Acute Pericardial Effusion following Catheter Ablation of Atrial Fibrillation | Drug: Colchicine<br>* Impact of Colchicine therapy on arrhythmia Recurrence after Acute Pericardial Effusion following Catheter Ablation of Atrial Fibrillation<br>* Other names: Impact of Colchicine;|
| No Intervention: No intervention<br>No intervention | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| recurrence of atrial arrhythimia | Assessment of the recurrence of atrial arrhythimia 1 year after colchicines administration | 1 year after colchicines administration | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| recurrence of atrial arrhythimia | Assessment of the recurrence of atrial arrhythimia 3 year after colchicines administration | 3 year after colchicines administration | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pericardial Effusion, Colchicine, arrhythmia Recurrence, pericardiocentesis