Misoprostol Versus Active Management of Labour in CS

Study Overview
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Brief Summary
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Several treatment strategies are emplemented to prevent post delivery hemorage and decreasing maternal morbidity and mortality .

Detailed Description
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Many approved drugs are used in prophylaxis against postpartum hemorage from these medications are the (syntocinon combined with methergine ) that are known as active management of labour drugs . Moreover there is misotac , that also guards against postpartum hemorage . All these medications act in a different way to cause uterine contraction post delivery to prevent uterine atony . -Here we are comparing the additive value of misotac intrauterine to syntocinon and methergine in comparison to the usually used syntocinon plus methergine .

Official Title
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Intrauterine Misoprostol With Active Management of Labour Versus Active Management of Labour for Prevebtion of Postpartum Hemorage in Cesarean Section ,Randomized Controlled Trial

Conditions
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Cesarean Section

Intervention / Treatment
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* Drug: Misoprostol + syntocinon and using extra uterotonic drugs when needed ; methergine
* Drug: Syntocinon and using extra uterotonic drugs when needed ; methergine carboprost


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • All patients included in this research were aged 18-42 years, pregnant 37 weeks till 42 weeks no medical disorders with pregnancy e.g DM, HTN. All patients were subjected to full history taking, examination. Exclusion Criteria: Exclusion Criteria: The following patients were excluded , GA before 37 weeks or after 42 weeks , medical disorders with pregnancy eg. DM with pregnancy, HTN with pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 42 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Extra medication group<br>-Procedure : Giving misoprostol plus syntocinon during CS this group in which prevention of uterine atony is made by intrauterine misoprostol plus the usual syntocinon and using extra uterotonic drugs when needed ; methergine , carboprost | Drug: Misoprostol + syntocinon and using extra uterotonic drugs when needed ; methergine<br>* medical prophylaxis against postpartum atony and postpartum hemorage by giving misoprostol plus syntocinon and using extra uterotonic drugs when needed ; methergine, carboprost<br>* Other names: DrugsMisoprostol plus syntocinon and using extra uterotonic drugs when needed ; methergine , carboprost;|
| Active Comparator: Active management of labour group<br>Procedure: Giving syntocinon during cesarean section this group in which prevention of uterine atony is made by the usual active management of labour syntocinon and using extra uterotonic drugs when needed ; methergine , carboprost | Drug: Syntocinon and using extra uterotonic drugs when needed ; methergine carboprost<br>* medical prophylaxis against postpartum atony and postpartum hemorage by giving syntocinon and using extra uterotonic drugs when needed ; methergine, carboprost<br>* Other names: drugs ( syntocinon and using extra uterotonic drugs when needed ; methergine, carboprost;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The number of participants who passed cesarean section without postpartum hemorage |  | within 2 days post CS |