COVID19 Hospitilized in Clinica Pasteur of Neuquen (Argentina)

Study Overview
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Brief Summary
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retrospective cohort (non-experimental study) of COVID 19 patients assisted in hospitalization (severe and critical) between 2020 and 2021

Detailed Description
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Consecutive patients with acute infection by SARS-COV2 and severe or critical COVID19 disease, or acute complications, hospitalized in the Pasteur Clinic of Neuquén city from the beginning of the pandemic in the region until December 31, 2021. Data were obtained retrospectively from information registered simultaneously with hospitalization in three databases (RedCap, DataTech and Excel). . Inclusion criteria Adult patients (over 18 years old) Suffering from acute infection by SARS-Cov2, diagnosed by PCR-real time, detection of viral antigen, specific antibodies with or clinical epidemiological criteria Hospitalized defined by attending physicians or referral (severe or critical according to NIH) Exclusion criteria Patients under 18 years of age. Convalescent from acute SARS-Cov2 infection and without evidence of a new event of reinfection. Outpatient management or hospitalization less than 24 hours for diagnosis and / or evaluation of severity or complications. Sample Selection Method First patient was registered at the beginning of the pandemic in the region March 20, 2020) and is expected to recruit the las patient diagnosed in December 31, 2021. The recruitment is consecutive without other selection criteria.

Official Title
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Cohort of COVID19 Patients Admitted to Pasteur Clinic 2020-2021

Conditions
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COVID-19

Intervention / Treatment
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* Other: Comorbidities


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patients (over 18 years old) Suffering from acute infection by SARS-Cov2, diagnosed by PCR-real time, detection of viral antigen, specific antibodies with or clinical epidemiological criteria Hospitalization defined by attending or referral physician (severe or critical according to NIH) Exclusion Criteria: Patients under 18 years of age. Convalescent from acute SARS-Cov2 infection and without evidence of a new event reinfection. Outpatient management or hospitalization less than 24 hours for diagnosis and / or evaluation of severity or complications.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Comorbidities|Risk factors (comorbidities), requirements of respiratory suppot and chest imaging will are considered exposure for primary outcomes|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 28-day mortality | defined as death ocurred within 28 days of admition to hospital | From date of admition until the date of death from any cause, assessed up to 28 day | 
| Hospital mortality | defined as death ocurred within hospitalization | From date of admition until the date of death from any cause, assessed up to 52 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Invasive Mechanical ventilation | defined as requirement of invasive mechanical ventilation support | From date of admition until the date of equirement of invasive mechanical ventilation, assessed up to 21 day |