mFOLFOX7 Plus Camrelizumab and Apatinib for Advanced HCC

Study Overview
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Brief Summary
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This is a prospective, one-arm, phase II clinical study of intravenous mFOLFOX6 plus Camrelizumab combined with apatinib for CNLC stage III hepatocellular carcinoma

Official Title
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Intravenous mFOLFOX7 Plus Camrelizumab and Apatinib for CNLC Stage III Hepatocellular Carcinoma

Conditions
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Stage III Hepatocellular Cancer (CNLC Staging)

Intervention / Treatment
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* Drug: mFOLFOX7+Camrelizumab+Apatinib


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients volunteered to participate in this study and signed informed consent; Age 18-75, male or female; ECOG PS score 0-2; Child-pugh liver function grading: Grade A or B The clinical diagnosis conforms to primary hepatocellular carcinoma (HCC) and the lesion conforms to stage III according to China liver cancer staging (CNLC) Did not received any type of other first-line drugs such as Sorafenib According to RECIST 1.1 standard, patients have at least one measurable lesion (CT/MRI scan long diameter ≥10mm or CT/MRI scan short diameter ≥15mm for lymph node lesions, and the lesion has not received radiotherapy, freezing or other local treatments); Expected survival ≥ 12 weeks; The function of vital organs meets the following requirements (excluding the use of any blood component and cell growth factor within 14 days) : Blood routine: White blood cells count ≥3.0×109/L Platelet count ≥70×109/L Hemoglobin ≥80g/L; Liver and kidney function: Serum creatinine (SCr) ≤ 1.5 times upper limit of normal value (ULN) or creatinine clearance ≥50 ml/min (Cockcroft-Gault formula); Total bilirubin (TBIL) ≤ 1.5 times the upper limit of normal value (ULN); AST or ALT levels ≤ 3 times the upper limit of normal value (ULN) Women of childbearing age should agree to use contraceptives (such as intrauterine devices, contraceptives or condoms) during and within six months of the end of medication;Patients with negative serum or urine pregnancy tests within 7 days prior to study inclusion and who must be non-lactating, and males should agree to use contraceptives during the study period and for 6 months after the end of the study period. Subjects have good compliance and cooperate with the follow-up. Subjects with HBV or HCV infection should receive anti-virus treatment without interfron. Exclusion Criteria: Have received immunotherapeutic drugs or interferon in the past. Severe allergic reaction to other monoclonal antibodies. Female subjects with pregnancy. Patients with congenital or acquired immune deficiencies. Abnormal coagulation function (INR>2.0, PT>16s), have bleeding tendency or are receiving thrombolysis or anticoagulation therapy, and allow preventive use of low-dose aspirin and low-molecular-weight heparin The patient has suffered from other malignant tumors at the same time (except for cured skin basal cell carcinoma and cervical carcinoma in situ) The patient has active infection, fever of unknown origin within 7 days (CTCAE>2) Patients with congenital or acquired immune deficiencies. With clinical symptoms or diseases of the heart that are not well controlled. According to the judgment of the investigator, the patients with factors that may affect the results of the study or cause the study to be terminated midway, such as alcoholism, drug abuse, other serious diseases (including mental illness) need to be treated together, severe laboratory abnormalities, accompanied by family or social factors, which will affect the safety of patients

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: intravenous mFOLFOX7 combined with Camrelizumab and apatinib<br>Drug: Leucovorin 200mg/m2 administered IV on Days 1 of a 21 day cycle Drug: Oxaliplatin 85 mg/m2 IV on Days 1 of a 21 day cycle. Drug: Fluorouracil 5-FU continuous infusion: 400mg/m2 on D1 and then 2400mg/m2 for 46h of each 21 day cycle. Drug: Camrelizumab 200mg infusion on D1 for every 21 days Drug: Apatinib 250mg，po，qd for every 21 days | Drug: mFOLFOX7+Camrelizumab+Apatinib<br>* Drug: Leucovorin 200mg/m2 administered IV on Days 1 of a 21 day cycle Drug: Oxaliplatin 85 mg/m2 IV on Days 1 of a 21 day cycle. Drug: Fluorouracil 5-FU continuous infusion: 400mg/m2 on D1 and then 2400mg/m2 for 46h of each 21 day cycle. Drug: Camrelizumab 200mg infusion on D1 for every 21 days Drug: Apatinib 250mg，po，qd for every 21 days<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ORR | RECISTv1.1 | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mORR | mRECIST | 1 year | 
| DOR |  | 1 year | 
| DCR |  | 1 year | 
| PFSR |  | 1 year | 
| conversion rate | unresectable converted into resectable | 1 year | 
| PFS |  | 1 year | 
| OS |  | 1 year | 
| TRAE |  | 1 year |