Study Investigating Tooth Movements With Conventional and Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) Supported Fixed Appliances

Study Overview
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Brief Summary
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In orthodontics, conventional fixed appliances, usually consisting of prefabricated components, require step-by-step adjustment in order to move teeth in the planned direction. May treatment be improved with customized archwires? Study hypotheses: By using CAD/CAM in planning and fabrication of customized archwires, unnecessary tooth movements can be avoided and teeth can be moved on their direct path to the intended position. The application of CAD/CAM improves reproducibility, efficiency, and quality of orthodontic treatment.

Official Title
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Pilot Study Investigating Tooth Movements With Conventional and CAD/CAM Supported Fixed Appliances

Conditions
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Tooth Movement, Orthodontics

Intervention / Treatment
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* Procedure: orthodontic treatment with customized archwires
* Procedure: orthodontic treatment with prefabricated archwires
* Procedure: orthodontic tx w/ conventional archwires+manual adjustments


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: treatment of front teeth with fixed orthodontic appliances is indicated complete secondary dentition age: 18-35 in healthy general condition patient is informed about study and agrees to participate Exclusion Criteria: treatment of premolars and molars is necessary syndromes affecting bones and teeth cleft lip and palate inflammation or reduction (more than 50%) of periodontium intake of drugs affecting tooth movement and bone formation disturbance of bone formation disturbance of thyroidal function pregnancy participation in additional study affecting oral hygiene former therapy with ionized radiation or cytostatic drugs caries (active phase) alcohol dependency

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>CAD/CAM group, customized archwires | Procedure: orthodontic treatment with customized archwires<br>* customized arch wires depending on the amount of needed tooth movement<br>* Other names: CAD/CAM;|
| Active Comparator: 2<br>prefabricated archwires (superelastic) | Procedure: orthodontic treatment with prefabricated archwires<br>* prefabricated archwires depending of the needed movement of the teeth<br>* Other names: conventional orthodontic treatment;|
| Active Comparator: 3<br>prefabricated archwires with manual adjustments | Procedure: orthodontic tx w/ conventional archwires+manual adjustments<br>* conventional archwires modified by manual adjustment, depending of needed correction<br>* Other names: conventionel archwires;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sum of differences between resulted and shortest path of tooth movements in each patient |  | measurements every 14 days until end of treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference between resulted and shortest path of movements for each tooth |  | measurements every 14 days until end of treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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CAD/CAM, orthodontics, fixed appliance, tooth movement