Acute Cardiovascular Responses and Chronic Adaptations of Strength Exercise in Intermittent Claudication Patients

Study Overview
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Brief Summary
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The aim of this study was to analyze the effects of resistance exercise and training on cardiovascular function of peripheral artery disease patients.

Detailed Description
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Several studies have shown that strength training can promote important benefits for the cardiovascular system in healthy subjects and patients with chronic diseases. However, the effects of resistance exercise on cardiovascular function in intermittent claudication patients are unclear. In addition, it also do not know the chronic effects on cardiovascular function in these patients.

Official Title
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Acute Cardiovascular Responses and Chronic Adaptations of Strength Exercise in Intermittent Claudication Patients

Conditions
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Peripheral Artery Disease, Intermittent Claudication

Intervention / Treatment
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* Behavioral: Resistance training
* Behavioral: Control


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Had a graded treadmill test that was limited by claudication (2 minutes) Had an ankle brachial index <0.90 Had systolic blood pressure ,160 mmHg and/or diastolic blood pressure,105 mmHg Were not performing any regular exercise program Were not using antihypertensive medications affecting the heart rate (e.g., b-blockers and nondihydropyridine calcium channel blockers) Were nonobese Individuals who have not undergone bypass surgery or angioplasty least one year ago Exclusion Criteria: Had no symptoms related to myocardial ischemia during the treadmill test Amputation

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Resistance Training<br>Patients performed resistance exercises | Behavioral: Resistance training<br>* Resistance training exercises<br>* Other names: Physical training;|
| Active Comparator: Control<br>Patients who performed flexibility exercise | Behavioral: Control<br>* Stretching exercises<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in blood pressure |  | Change from baseline to 12 and 24 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Walking distance |  | Change from baseline to 12 and 24 weeks | 
| Change in Health related Quality of life |  | Change from baseline to 12 and 24 weeksBaseline, 12 wks and 24 wks | 
| Change in Muscle blood flow of limbs | Muscle blood flow assessed with venous occlusion plethysmography | Change from baseline to 12 and 24 weeks | 
| Change in body fat |  | Change from baseline to 12 and 24 weeks | 
| Change Serum Cholesterol |  | Change from baseline to 12 and 24 weeks | 
| Change in serum glucose |  | Change from baseline to 12 and 24 weeks | 
| Change in TNFalpha |  | Change from baseline to 12 and 24 weeks | 
| Change in Score Short-physical performance battery |  | Change from baseline to 12 and 24 weeks |