Interaction Research on Cognitive Impairment and Emotional Disorder in End-stage Renal Disease

Study Overview
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Brief Summary
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End stage renal disease (ESRD) is the last stage (stage 5) of chronic kidney disease (CKD). Abnormalities of cognitive function and high levels of depression or anxiety incidence are characteristic of hemodialysis patients. In this research project, the investigators subject in ESRD patients starting hemodialysis as the carrier. Based on the longitudinal research design, using multimodal neuroimaging data，combining with the interact relationship between changes of brain morphology, the dysfunction of resting-state and-task state with cognitive impairment and abnormal emotions.Establish brain structure-function change model associated with dialysis progression, Explore imaging markers of central and disease development characteristics in ESRD patients. the investigators attempt to clarify the core mechanism of kidney-brain axis damage, thus provide evidence for early cognitive-behavioral therapy to CKD patient.

Official Title
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Interaction Research on Cognitive Impairment and Emotional Disorder in End-stage Renal Disease

Conditions
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Brain Damage, End-stage Kidney Disease

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18-50 years; ESRD patients who will start hemodialysis High quality MRI scan; dextromanual Exclusion Criteria: Diabetes,Brain tumor,brain trauma Neuropsychiatric disease

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control Group<br>Health adults with no evidence of brain lesions on conventional magnetic resonance imaging(MRI) and no neural developmental disorders. | |
| Patients Group<br>ESRD patients pre-hemodialysis will be collected.The following exclusion criteria were applied in this study: (a)history of drug or alcohol abuse, (b) brain lesions such as a tumor or stroke assessed on the basis of medical history, (c) history of or current psychiatric disorders, and (d) head motion more than 1.0 mm or 1.0°during magnetic resonance imaging. All patients completed laboratory tests to evaluate renal function,serum creatinine, and urea levels within the 12 hours before magnetic resonance imaging. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in cognitive function | Cognitive testing will be performed for assessment | Change from Baseline to 3 Months after dialysis | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in brain MRI | Brain MRI will be performed before dialysis initiation and dialysis more than 3 months | Change from Baseline to 3 Months after dialysis | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cognitive impairment, ESRD, functional MRI