China PEACE 5p-HF Study

Study Overview
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Brief Summary
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The investigators will consecutively recruit 5000 patients hospitalized for heart failure (HF) from 50 hospitals across China and follow them up for one year, describe treatment patterns during hospitalization and the follow-ups, examine patients recovery trajectory after HF, and identify targets for care quality improvement.

Detailed Description
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This study will consecutively enroll patients with HF as the primary reason for hospitalization in 50 hospitals scattered all over China. Participants will be interviewed at baseline (i.e., during the index hospitalization for HF), and at 1, 6, and 12 months following hospital discharge. During the follow-up period, participants will be instructed to return to the hospital for interviews by site investigators. Telephone follow-ups will be conducted only when in-person interviews are not feasible. At baseline, participants will be interviewed to collect detailed information about on demographics, socioeconomic status, cardiovascular risk factors, clinical characteristics, treatments, in-hospital outcomes, general and disease-specific quality of life, function and mental status; during the follow-ups, the investigators will collect information about clinical outcomes events, long-term treatments, function, quality of life, symptoms, and medical care during the recovery period. The investigators will collect blood and urine samples during index hospitalization and the follow-ups. This study will examine a series of factors that may affect patients' recovery after HF. Practical guidelines, quality evaluative system, and risk model will be established based on the findings, to improve patient outcomes in the future.

Official Title
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China Patient-centered Evaluative Assessment of Cardiac Events (PEACE): Prospective Study of Patients With Heart Failure (HF)

Conditions
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Heart Failure

Intervention / Treatment
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* Other: Observational study


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with heart failure as the primary reason for hospitalization, including both new-onset HF or decompensation of chronic HF Aged 18 years or above Exclusion Criteria: Patients who have enrolled in this study Patients who usually do not live in the city/county where the index hospital locates Patients who are unable to complete interviews due to severe conditions, mental illness, or communication difficulties.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Observational study|This is a non-interventional study, patients receive their usual treatment as determined by the physician.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Major adverse cardiac events | Major adverse cardiac events is defined as the composite of cardiovascular death, resuscitated sudden death, HF-related rehospitalization, myocardial infarction, stroke, and incident atrial fibrillation. | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Death | Cardiovascular death and non-cardiovascular death | 1 year | 
| Rehospitalization | HF-related and non HF-related | 1 year | 
| Resuscitated sudden death |  | 1 year | 
| Myocardial infarction |  | 1 year | 
| Stroke |  | 1 year | 
| Incident atrial fibrillation |  | 1 year | 
| Incident renal insufficiency |  | 1 year | 
| Quality of life (EQ-5D) |  | 1 year | 
| Quality of life for HF (KCCQ-12) |  | 1 year | 
| Depression (PHQ-8) |  | 1 year | 
| Stress (PSS-4) |  | 1 year | 
| Anxiety (GAD-2) |  | 1 year | 
| Function of cognition (Mini-cog) |  | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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heart failure, prospective, cohort