Periventricular White Matter Hyperintensities in Cerebral Amyloid Angiopathy and Hypertensive Arteriopathy

Study Overview
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Brief Summary
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White matter hyperintensities (WMH) are one of the small vessel disease-related MRI characteristics of both cerebral amyloid angiopathy (CAA) and hypertensive arteriopathy (HA). WMH tend to show a peri-basal ganglia pattern in HA, whereas a multiple subcortical spots pattern can be observed in CAA. Periventricular WMH (PVWMH) have been reported to be posterior predominant using a semiautomated segmentation method and logarithmic transformation, not used in daily clinical practice. In these studies including CAA patients, patients initially presented with haemorrhage-related symptoms. In another study analysing PVWMH and cerebral amyloid evidence in patients with mild cognitive impairment, frontal PVWMH burden was associated with high uptake on florbetapir-PET whereas parietal and occipital PVWMH burden was associated with low CSF-amyloid-beta. The aim of this study is the descriptive comparative analysis of the distribution of PVWMH between CAA and HA patients with radiological tools available in daily practice.

Official Title
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Periventricular White Matter Hyperintensities in Cerebral Amyloid Angiopathy and Hypertensive Arteriopathy

Conditions
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Cerebral Amyloid Angiopathy, Hypertensive Arteriopathy

Intervention / Treatment
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* Other: None, pure observational study


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: CAA and HA patients, managed at Nîmes University Hospital between January 2015 and March 2022. Exclusion Criteria: CAA and HA patients, treated at the CHU of Nîmes between January 2015 and March 2022, not objecting to the use of their health data

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| cerebral amyloid angiopathy<br>Patient with cerebral amyloid angiopathy | Other: None, pure observational study<br>* None, pure observational study<br>|
| Hypertensive arteriopathy<br>Patients with hypertensive arteriopathy | Other: None, pure observational study<br>* None, pure observational study<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Distribution of PVWMH | Maximal distance between the outer PVWMH border and the border of the lateral ventricle (on the axis oriented at 90° to the border of the ventricle) | Base line, Day 0 | 
| Distribution of PVWMH - total PVWMH extent. | The sum of the PVWMH measurements around the four ventricles horns (i.e. bilateral anterior and posteriors horns) resulted in total PVWMH extent. | Base line, Day 0 | 
| Corpus callosum (CC) WMH | Distance between the border of the third ventricle and the outer border of the WMH on the rostro-caudal axis, resulting in anterior and posterior CC-PVWMH extent measurements. | Base line, Day 0 | 
| Corpus callosum (CC) WMH - total CC-PVWMH extent. | The sum of the anterior and posterior CC-PVWMH measurements resulted in the total CC-PVWMH extent. | Base line, Day 0 | 
| Ratios | Calcul of posterior/anterior ratios for both the PVWMH and CC-PVWMH | base line, day 0 | 
| Anterior PVWMH | Comparison of anterior PVWMH between CAA group and HA group. | Base line, Day 0 | 
| Posterior PVWMH | Comparison of posterior PVWMH between CAA group and HA group. | Base line, Day 0 | 
| Total PVWMH | Comparison of total PVWMH between CAA group and HA group. | Base line, Day 0 | 
| Posterior/anterior PVWMH ratio | Comparison of the posterior/anterior PVWMH ratio between CAA and HA groups. | Base line, Day 0 | 
| anterior CC-PVWMH | Comparison of anterior CC-PVWMH between CAA group and HA group. | Base line, Day 0 | 
| Posterior CC-PVWMH | Comparison of posterior CC-PVWMH between CAA group and HA group. | Base line, Day 0 | 
| Total PVWMH and posterior/anterior CC-PVWMH ratio | Comparison of total PVWMH and posterior/anterior CC-PVWMH ratio between CAA group and HA group. | Base line, Day 0 |