Study of Segmental Renal Artery Clamping During Laparoscopic Partial Nephrectomy

Study Overview
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Brief Summary
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The purpose of this study is to compare the efficacy and safety of the segmental artery clamping and main renal artery clamping during laparoscopic partial nephrectomy

Detailed Description
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Renal tumor patients,for whom laparoscopic partial nephrectomy is suitable, will be randomly divided into two groups,segmental artery clamping group and main artery clamping group. All procedures were performed by the same laparoscopic surgeon. Blood loss, operation time, warm ischemia time, complications and affected renal function before and after operation will be recorded and compared. The safety and efficiency of laparoscopic partial nephrectomy with segmental renal artery clamping will be evaluated in comparison with the conventional main renal artery clamping technique.

Official Title
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A Randomized Controlled Trial Comparing the Segmental Artery Clamping and Main Renal Artery Clamping During Laparoscopic Partial Nephrectomy

Conditions
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Kidney Neoplasms, Renal Cell Carcinoma

Intervention / Treatment
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* Procedure: Segmental artery clamping
* Procedure: Main renal artery clamping


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 20<age<70yr Stage T1a Patients volunteered for this study and provided written informed consent Exclusion Criteria: Bilateral renal tumor tumor of solitary kidney glomerulonephritis renal insufficiency GFR of invalid kidney less than 30ml/min presence of suspect metastasis serious systematic disease: severe coagulation disorders important organ insufficiency and severe psychological disease

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Segmental artery clamping<br>Patients with Renal tumor are randomized into this group,they will received laparoscopic partial nephrectomy. During operation, the technique of segmental renal artery clamping will performed. | Procedure: Segmental artery clamping<br>* Laparoscopic partial nephrectomy with segmental artery clamping will be performed for patients enrolled in this group.<br>|
| Active Comparator: Main renal artery clamping<br>Patients with renal tumor are randomized into this group,they will received laparoscopic partial nephrectomy. During operation, the technique of traditional main renal artery clamping will be performed. | Procedure: Main renal artery clamping<br>* Laparoscopic partial nephrectomy with main renal artery clamping technique will be performed for patients enrolled in this group.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glomerular Filtration Rate |  | 3 months postoperative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| warm ischemia time |  | during surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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laparoscope, renal tumour, partial nephrectomy, segmental renal artery clamping