Clinical Evaluation of Platelet Rich Fibrin Versus Subepithelial Connective Tissue Graft for Soft Tissue Augmentation

Study Overview
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Brief Summary
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Soft tissue biotype is a critical factor for success of implant in the esthetic zone . Different soft tissue augmentation techniques have been employed to increase soft tissue thickness such as: autogenous grafts, allografts, xenografts and living cellular construct (LCC). Studies showed that, allografts and xenografts were inferior when compared with autogenous graft . However, few studies were conducted to evaluate the efficacy of soft tissue augmentation with platelet rich fibrin in order to overcome the patient morbidity with SCTG.

Official Title
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Clinical Evaluation of Platelet Rich Fibrin Versus Subepithelial Connective Tissue Graft for Soft Tissue Augmentation Around Implant in the Aesthetic Zone: A Randomized Control Clinical Trial

Conditions
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Thin Gingival Biotype, Patients With at Least Single Missing Anterior Tooth

Intervention / Treatment
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* Procedure: Platelet Rich Fibrin
* Procedure: sub epithelial connective tissue graft


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with missing maxillary anterior toot teeth. Thin gingival biotype. Adequate inter-arch space for placement of the implant prosthetic part. Good oral hygiene where gingival index is (0, 1) (Loe and Silness 1963). Exclusion Criteria: Patient with medical condition that is contraindicated with the surgical procedure Patients receiving treatment that affect the healing ability. Patients with local pathological defects related to the area of interest. Smokers or pregnant women. Patients with parafunctional habits that may jeopardize the implant longevity and affect the results of the study.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Platelet Rich Fibrin for soft tissue augmentation<br>blood will be drawn from the patient vein for PRF. The blood sample will be centrifuged for 10-12 min. PRF membrane is obtained | Procedure: Platelet Rich Fibrin<br>* : Platelet Rich Fibrin for soft tissue augmentation around implant in the aesthetic zone<br>|
| Active Comparator: sub epithelial connective tissue graft<br>The connective tissue graft will be harvested from the palate. Then the SCTG will be placed over the recipient site extending palataly and sutured. | Procedure: sub epithelial connective tissue graft<br>* sub epithelial connective tissue graft for soft tissue augmentation around implant in the aesthetic zone<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Crestal bone resorption | measured mesially and distally using periapical xray in mm | 6 months |