Collection of Blood for Gene Expression/Genomic Studies in Individuals With Diabetes (Qatar)

Study Overview
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Brief Summary
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This protocol is designed to gather a small amount of blood for extraction of DNA for the study of the genetic basis of diabetes. The study population will include individuals with known diabetes, and controls without diabetes. Investigators aim to understand the genetics of diabetes, and will use the cells and serum from this blood to perform genotyping and gene expression studies of individuals with diabetes and relevant controls.

Detailed Description
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This protocol is designed to collect a small amount of blood for extraction of DNA (genetic material) for the study of the genetic basis of diabetes. The study population will include individuals with known diabetes and controls without diabetes. Additionally, this protocol will recruit individuals from the following locations: the Qatar Diabetes Association, the governmental ministries of Qatar, and subjects who have participated in Dr. Bener's HMC protocol #231 entitled A preliminary study of genetic pre-disposition to diabetic mellitus in the state of Qatar. Individuals with diabetes may also be recruited from the Hamad Hospital outpatient adult diabetes clinics (there are eight diabetes clinics each week) and/or from the population of subjects who previously participated in Dr. Mushlin's IRB approved protocol #0608008703 entitled Comparing the Clinical Management and Genetic Markers of Diabetes in Qatar to International Standards at Hamad Medical Corporation or IRB approved protocol #0602008388 entitled The Impact of Cardiac and Genetic Risk Factors on Acute Myocardial Infarction and Cerebrovascular Stroke in Qatar: A Case-Control Study. In this protocol, researchers will survey medical records of patients with diabetes, in order to study the clinical characteristics of these individuals, and the researchers will collect blood to evaluate the genetic characteristics of individuals with diabetes. The researchers will also collect blood samples of individuals without diabetes to serve as control.

Official Title
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Collection of Blood for Gene Expression/Genomic Studies in Individuals With Diabetes (Qatar)

Conditions
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Diabetes Mellitus, Type 2 Diabetes Mellitus

Participation Criteria
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Eligibility Criteria
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Diabetes group Inclusion criteria: Must provide informed consent Males and females, age 18 years and older Documented evidence of diabetes using at least one of the following: (1) blood tests consistent with Type-II diabetes; (2) oral glucose tolerance tests consistent with Type-II diabetes; (3) subject taking medication to treat Type-II diabetes. Exclusion criteria: Individual refuses consent Pregnant females with gestational diabetes Type-I diabetes Normal control group Inclusion Criteria: Must provide informed consent Males or females ages 18 years and older Resolved gestational diabetes Exclusion Criteria: Individual refuses consent. Individuals with history of diabetes.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Diabetes<br>Individuals with diabetes that fit eligibility criteria. | |
| Normal Control<br>Individuals without history of diabetes. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Diabetes Mellitus, Diabetes, Type-2, Adult Onset