Norwegian COgnitive Impairment After STroke (NorCOAST) Study

Study Overview
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Brief Summary
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A prospective observational multicenter study aiming to describe incidence, and identify predictors for development of poststroke dementia (PSD) and mild cognitive impairment (MCI) after stroke

Detailed Description
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About 15000 Norwegians suffer a stroke every year and 2/3 will be more or less disabled. In addition to motor impairments and comorbidities, disability after stroke is often related to post stroke dementia (PSD) or mild neurocognitive disorder (NCD). However, these problems are hardly addressed in stroke or dementia research and frequently ignored in clinical practise. In the Nor-COAST study an interdisciplinary research group will collaborate to establish a research platform across all Norwegian Health Authorities. The overall aim of the study is to improve competence on PSD and NCD in order to improve individual health outcomes following a stroke. The specific objectives are to determine the incidence of PSD and NCD and the consequences on function and use of health care services and to enhance the early detection of PSD and NCD by identifying a set of risk factors, ranging from genetics to physical activity. The incidence and impact of PSD and NCD on function and use of health care services, medication and life-style changes are important when planning future health care services. Tools identifying patients at risk might improve diagnostic work up and together with knowledge on pathogenic aspects it will contribute to future treatment and prevention of PSD and NCD.

Official Title
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Norwegian COgnitive Impairment After STroke (NorCOAST) Study

Conditions
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Dementia, Mild Cognitive Impairment, Stroke

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Stroke diagnosis according to the WHO criteria Exclusion Criteria: Not scandinavian speaking

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Score on the Montreal cognitive assessment (MOCA) | Performance based test | 18 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Score on the Montreal cognitive assessment (MOCA) | Performance based test | 3 months | 
| Time spent in upright position | measured by bodyworn sensors | 3 months | 
| Time spent in upright position | measured by bodyworn sensors | 18 months | 
| Brain Imaging | MRI | 18 months | 
| Score on Short Physical Performance Battery (sppb) | Performance based test for mobility and lower extremity function | 3 months | 
| Score on Short Physical Performance Battery (sppb) | Physical function by performance based tests | 18 months | 
| Selfreported habits concerning smoking, alcohol, diet and medication using standardised questionnaires |  | 3 months | 
| Selfreported habits concerning smoking, alcohol, diet and medication using standardised questionnaires |  | 18 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Follow up studies, Risk factors