linjc16/ctgov huggingface dataset:
Pilot Study Using Radiostereometric Analysis (RSA) to Evaluate the Fixation of the Tibial Components in the DePuy M.B.T. Revision Knee System

Study Overview
=================
Brief Summary
-----------------
Motivated by the growing number of revision total knee arthroplasty (TKAs) and the interest among surgeons to quantify the effectiveness of specific implant designs, the goal of the current project is to use Radiostereometric Analysis (RSA) to provide conclusive and clinically relevant results on fixation of the tibial component with the DePuy M.B.T. Revision TKA system using Metaphyseal Sleeves. Does the tibial component of the M.B.T. Revision Knee System achieve adequate fixation to the underlying bone (proximal tibia) as measured by migration? • Null Hypothesis: The maximum total point motion (MTPM) value of migration of the M.B.T. Revision Knee System component between postoperative years one and two does not exceed 0.2 mm indicating adequate long-term fixation at the bone-implant interface. • Alternative Hypothesis: The MTPM value of migration of the M.B.T. Revision Knee System component between postoperative years one and two does exceed 0.2 mm indicating inadequate long-term fixation at the bone-implant interface. b) In what proportion of patients is adequate fixation achieved?

Official Title
-----------------
Pilot Study Using Radiostereometric Analysis (RSA) to Evaluate the Fixation of the Tibial Components in the DePuy M.B.T. Revision Knee System

Conditions
-----------------
Revision Total Knee Replacement

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Revision TKA is indicated and it is the opinion of the investigator that the PFC Sigma M.B.T. Tibial component with metaphyseal sleeves and a stem is a suitable treatment Contained bone defects in the proximal tibia that allow for contiguous contact between metaphyseal sleeves and cortical bone Use of tibial stem Ability to give informed consent Exclusion Criteria: Revision TKA due to infection Patellar revision only Polyethylene liner exchange only Revision requiring hinged TKA Uncontained defects in the proximal tibia that preclude contiguous contact between metaphyseal sleeves and cortical bone
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| MBT Revision Component<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Implant Migration |  | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| BMD |  | 2 years |
Predictors of Success Following Bariatric Surgery

Study Overview
=================
Brief Summary
-----------------
This study aims to consolidate the contributions of various medical, social and psychological predictors of success following bariatric surgery amongst Singaporeans.

Official Title
-----------------
Predictors of Success Following Bariatric Surgery

Conditions
-----------------
Focus of Study is Patient Responses to an Obesity Management Questionnaire Administered by SGH Life Centre

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Undergone bariatric surgery within SGH lIfe centre and must have completed the intake questionnaire. Exclusion Criteria: -
Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Weight Loss | Weight Loss in Kilograms | Immediately post-surgery within first year |
Prognosis of Bronchiectasis in Children--A Multicenter Prospective Cohort Study

Study Overview
=================
Brief Summary
-----------------
This prospective cohort study is designed to observe of the effect of intervention therapy on the long-term prognosis of children with bronchiectasis. The main purpose of the study was to evaluate the degree of deterioration of lung function, to observe and compare the quality of life, the time of pulmonary exacerbation, and the changes of lung image.

Detailed Description
-----------------
All enrolled patients are followed up for half a year, 1 years, 2 years, 3 years, 4 years, 5 years, while observation of pulmonary function, symptoms, signs, quality of life, the times of acute pulmonary exacerbation, and the changes of lung image are performed.

Official Title
-----------------
Prognosis of Bronchiectasis in Children--A Multicenter Prospective Cohort Study

Conditions
-----------------
Bronchiectasis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria:A included patient must be coincident at least one point of the four items of high-resolution computed tomography (HRCT) manifestations. Internal bronchial diameter greater than the accompanying pulmonary artery. lack of bronchial tapering bronchi visible in the peripheral 1cm of lung bronchial diameter greater than adjacent segmental bronchi Exclusion Criteria:Subject will be excluded if she or he has one of the following It is unable or doesn't agree to accept the follow-up process undergoing trial for other medications or instruments.

Ages Eligible for Study
-----------------
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in lung function on the spirometry | forced expiratory volume at one second (FEV1) in Liter | 5 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
children, prognosis
Effect of Ketamine+Propofol vs Remifentanyl+Propofol on Laryngeal Mask Insertion Conditions

Study Overview
=================
Brief Summary
-----------------
Laryngeal mask airway is a common tool for airway management during anesthesia in many surgeries. Insertion of laryngeal mask needs deep anesthesia, suppression of airway, stabile hemodynamic response. Many drug regimens has been used for this purpose. This study aimed to compare the insertion conditions of laryngeal mask by using ketamine+propofol versus remifentanil + propofol.

Official Title
-----------------
Effect of Ketamine+Propofol vs Remifentanyl+Propofol on Laryngeal Mask Insertion Conditions

Conditions
-----------------
Surgery

Intervention / Treatment
-----------------
* Drug: Ketamine
* Drug: remifentanyl
* Drug: propofol
* Device: laryngeal mask


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Surgery requires laryngeal mask Exclusion Criteria: Patient refusal, abdominal surgery required muscle relaxant, any allergy to ketamine or remifentanyl

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Ketamine<br>Ketamine+propofol | Drug: Ketamine<br>* To compare ketamine+propofol versus remifentanyl+propofol to maintain good laryngeal mask insertion conditions<br>* Other names: Remifentanyl;Drug: propofol<br> <br> Device: laryngeal mask<br> <br> |
| Remifentanyl<br>Remifentanyl+propofol | Drug: remifentanyl<br> <br> Drug: propofol<br> <br> Device: laryngeal mask<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| High laryngeal mask insertion scores |  | 3 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hypotension |  | 10 minutes | 
| Hypertension |  | 10 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Laryngeal mask, Ketamine, Remifentanyl
Intelligence Changes Following Minor Surgery

Study Overview
=================
Brief Summary
-----------------
Animal studies showed that many general anesthetics might result in neuron apoptosis and neurocognitive impairment in the developing brain. However results from human studies are conflicted. In present study, the investigators examined the association between early exposure to anesthesia and surgery for minor surgery and intelligence changes in adolescence using the Wechsler Intelligence Scale for Children.

Official Title
-----------------
Intelligence Performance in Adolescence After Early Exposure to Anesthesia and Minor Surgery

Conditions
-----------------
Hypospadia, Phimosis, Inguinal Hernia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Born from 1995 Male Parents or guardian agree to attend this study Undergone minor surgery (Repair of hypospadias, phimosiectomy, cryptorchidectomy or cryptorchidopexy and repair of inguinal hernia) Children who scarify the No.1 to No.3 but no experience of any surgery. Those who undergone minor surgery in Renji Hospital 4-6years ago. Exclusion Criteria: Any congenital central nervous system diseases Any congenital heart diseases Any congenital dysgnosia Birth weight less than 2kg Ever been hypoxic encephalopathy when birth

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 16 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Wechsler Intelligence Scale for Children | Wechsler Intelligence Scale for Children will be done after surgery, the expected average of 5 years after surgery. | Average 5 years after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Achenbach Child Behavior Checklist | Wechsler Intelligence Scale for Children will be done after surgery, the expected average of 5 years after surgery. | Average 5 years after surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Anesthestics, Minor surgery, Wechsler Intelligence Scale for Children, Cognitiion
The Effect of Amiloride and Spironolactone in Healthy Persons

Study Overview
=================
Brief Summary
-----------------
This study will investigate whether retaining potassium in the body will lead to changes in blood pressure and changes in blood and urine samples.

Detailed Description
-----------------
The purpose is to measure the effect of amiloride and spironolactone on: Renal function (GFR, u-AQP2, u-ENaCβ, u-cAMP, u-PGE2, CH20, FENa, FEK), Pulsbewave velocity, augmentation index and central blood pressure, Vasoactive hormones (PRC, AngII, Aldo, AVP, ANP, BNP and Endot), and Ambulatory blood pressure

Official Title
-----------------
The Effect of Amiloride and Spironolactone Measured on Cardiovascular and Kidney Related Variables in Healthy Subjects in a Double-blinded, Randomised, Placebo-controlled, Cross-over Study

Conditions
-----------------
High Blood Pressure

Intervention / Treatment
-----------------
* Drug: Amiloride
* Drug: Spironolactone
* Drug: Placebo
* Drug: Placebo and spironolactone
* Drug: Spironolactone


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy Non-smokers Exclusion Criteria: Smoking Under medical treatment

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Randomisation 1<br>Amiloride 5 mg twice daily for 28 days, later compared with spironolactone and placebo | Drug: Amiloride<br>* 1 tablet twice a day<br>Drug: Placebo and spironolactone<br>* 5mg twice daily<br>|
| Active Comparator: Randomisation 2<br>Spironolactone 25 mg twice daily, to be compared with placebo and amiloride | Drug: Spironolactone<br>* 1 tablet twice a day<br>Drug: Spironolactone<br>* 25mg twice daily<br>|
| Placebo Comparator: Placebo<br>calcium tablet | Drug: Placebo<br>* Placebo<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood pressure |  | 2 years |
Single Incision Laparoscopic Cholecystectomy

Study Overview
=================
Brief Summary
-----------------
The investigators aim to investigate the safety, feasibility and short-term outcomes of Single Incision Laparoscopic Cholecystectomy. The investigators hypothesize that Single Incision Laparoscopic Cholecystectomy is safe and feasible.

Detailed Description
-----------------
Laparoscopic cholecystectomy is the standard approach for the treatment of gallbladder disease. Laparoscopic cholecystectomy is now performed as an outpatient procedure and it commonly requires the use of 4 separate small incisions. Single incision or single access trans-umbilical surgery may provide less pain, scarring and may improve patient's overall satisfaction. In this phase I trial we aim to evaluate the safety, feasibility and short-term outcomes of Single Incision Laparoscopic Cholecystectomy for the treatment of symptomatic cholelithiasis (gallstones).

Official Title
-----------------
Single Incision Laparoscopic Cholecystectomy

Conditions
-----------------
Cholelithiasis

Intervention / Treatment
-----------------
* Procedure: Single Incision Laparoscopic Cholecystectomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adults male and female(>18 years old) Capable of giving informed consent Ultrasound proven cholelithiasis Symptomatic cholelithiasis Elective cholecystectomy Exclusion Criteria: Pregnancy Contraindications for general anesthesia Morbid obesity Multiple previous abdominal surgeries Uncontrolled medical conditions Acute cholecystitis

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Surgical group<br>Patients with ultrasound proven symptomatic cholelithiasis (gallstones). | Procedure: Single Incision Laparoscopic Cholecystectomy<br>* A single trans-umbilical incision laparoscopic cholecystectomy will be performed by standard fashion and under general anesthesia.<br>* Other names: Cholecystectomy;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Safety and feasibility |  | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Short-term clinical outcomes |  | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Single Incision, Single Access, Surgery, Cholecystectomy
Cardiac Uptake of Metformin, Visualized by Positron Emission Tomography

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to evaluate if metformin is taken up into the failing myocardium. Recent experimental and epidemiological studies have shown beneficial effects of metformin on heart failure. It is unknown whether this effect is direct or indirect. The aim of the study is to investigate if metformin is taken up in heart failure using a novel 11C-metformin tracer and positron emission tomography (PET).

Official Title
-----------------
Cardiac Uptake of Metformin and Expression of Metformin Membrane Transporter Proteins in the Human Failing Myocardium

Conditions
-----------------
Heart Failure, Systolic

Intervention / Treatment
-----------------
* Radiation: 11C-metformin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with chronic heart failure, Left Ventricular Ejection Fraction <45% New York Heart Association (NYHA) class I, II, III Relatively preserved renal function (eGFR > 30 ml/min) Ability to understand the written patient information and to give informed consent Negative p-HCG for women of childbearing potential Exclusion Criteria: Known allergy to metformin Age < 18 years Current abuse of alcohol or drugs

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: All 6 subjects allocated to the study will receive 11C-metformin intravenously.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 11C-metformin<br>All participants allocated to the study will be included in this arm | Radiation: 11C-metformin<br>* 200 MBq of 11C-metformin is injected in the cubital vein. The participant is then scanned for 120 min using Positron Emission Tomography<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Metformin uptake in the failing myocardium | Cardiac uptake is evaluated through analysis of acquired PET-images. | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Metformin, Heart Failure, Organic cation transporter, Pharmacogenetics, Pharmacokinetics, Positron Emission Tomography
The Effects of Three Oral Medications on Post-operative Pain Following Endodontic Treatment

Study Overview
=================
Brief Summary
-----------------
Aim: eliminating or reducing pain following endodontic treatment is of great importance. The aim of this study is to compare the effects of Tramadol, Novafen and Naproxen on post-operative pain following instrumentation of root canals in teeth with irreversible pulpitis. Sample size: one hundred patients considering the inclusion and exclusion criteria were selected. Intervention and outcome: The effect of Tramadol, Novafen and Naproxen on post-operative pain following instrumentation of root canals in teeth with irreversible pulpitis was evaluated.

Conditions
-----------------
Pulpitis, Pain Management

Intervention / Treatment
-----------------
* Drug: Placebo
* Drug: Tramadol
* Drug: Novafen
* Drug: Naproxen


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The subjects were 20-60 years of age with no systemic diseases and females were not pregnant; No history of taking any analgesics or other drugs prior to presenting for treatment; Patients had moderate to severe pain associated with irreversible pulpitis in single-rooted premolars or anterior teeth. Exclusion Criteria:

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Parallel Assignment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Placebo|Placebo|
|Drug: Tramadol|Tab, 100mg in 6, 12 and 24 hours after root canal treatment|
|Drug: Novafen|325 mg in 6, 12 and 24 hours after root canal treatment|
|Drug: Naproxen|Tab, 500 mg in 6, 12, and 24 hours after root canal treatment|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Endodontics, pain, visual analogue scale, NSAIDs
Tendon Mechanical Properties and Morphological Characteristics of Human Bicep and Tricep Muscles: An In Vivo Ultrasonographical Study

Study Overview
=================
Brief Summary
-----------------
This current study tests whether the load-displacement and stress-strain characteristics of human bicep and tricep muscles and tendons change during graded maximal voluntary elbow extension and flexion exercises.

Official Title
-----------------
Tendon Mechanical Properties and Morphological Characteristics of Human Muscle

Conditions
-----------------
Healthy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy male subjects Age range from 18-35 years Exclusion Criteria: History of shoulder/elbow which needs medical treatment or surgery

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
muscle, tendon