Sirolimus, Gemcitabine Hydrochloride, and Cisplatin in Treating Patients At High Risk for Cholangiocarcinoma Recurrence After Liver Transplant or Surgery

Study Overview
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Brief Summary
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This pilot phase I trial studies the side effects and best way to give sirolimus, gemcitabine hydrochloride, and cisplatin in treating patients at high risk for cholangiocarcinoma recurrence after liver transplant or surgery. Sirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as gemcitabine hydrochloride, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving sirolimus with gemcitabine hydrochloride and cisplatin may prevent disease recurrence in patients with a high risk of recurrence after a liver transplant or surgery.

Detailed Description
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PRIMARY OBJECTIVES: I. Assessment of the percentage of patients who are able to complete therapy through 4 and 6 months post-registration. SECONDARY OBJECTIVES: I. To describe the adverse events, rate of dose reductions, and quality of life in these patients. II. To summarize timed endpoints of time-to-recurrence, disease-free survival, overall survival, time to treatment failure, and time until treatment related grade 3+ adverse events. OUTLINE: Patients receive cisplatin intravenously (IV) over 1 hour and gemcitabine hydrochloride IV over 30 minutes on days 1 and 8, and sirolimus orally (PO) daily or three times weekly. Treatment repeats every 3 weeks for up to 8 courses in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up every 6 months for up to 5 years.

Official Title
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Pilot Trial of Sirolimus, Gemcitabine and Cisplatin for Patients With High Risk for Cholangiocarcinoma Recurrence

Conditions
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Hepatic Complication

Intervention / Treatment
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* Drug: Cisplatin
* Drug: Gemcitabine Hydrochloride
* Other: Quality-of-Life Assessment
* Drug: Sirolimus


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Histologic proof of presence of residual tumor in liver explants and /or positive resection margins Absolute neutrophil count (ANC) >= 1500/μL obtained =< 7 days prior to registration Platelets (PLT) >= 100,000/μL obtained =< 7 days prior to registration Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) obtained =< 7 days prior to registration Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x ULN obtained =< 7 days prior to registration (=< 5 x ULN in patients with liver metastases) Creatinine =< 1.5 x Institutional ULN obtained =< 7 days prior to registration Alkaline phosphatase =< 5 x institutional ULN obtained =< 7 days prior to registration Hemoglobin (Hgb) >= 9.0 g/dL obtained =< 7 days prior to registration International normalized ratio (INR) and partial thromboplastin (PTT) =< 3.0 x ULN (anticoagulation is allowed if target INR =< 3.0 x ULN on a stable dose of warfarin or on a stable dose of low molecular weight [LMW] heparin for > 2 weeks at time of registration) Fasting serum glucose < 1.5 x ULN obtained =< 7 days prior to registration Fasting serum cholesterol =< 300 mg/dL OR =< 7.75 mmol/L AND fasting triglycerides =< 2.5 x ULN obtained =< 90 days prior to registration; NOTE: In case one or both of these thresholds are exceeded, the patient can only be included after initiation of appropriate lipid lowering medication Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1 or 2 Ability to provide informed consent Willingness to return to Mayo Clinic for follow up Life expectancy >= 12 months Women of childbearing potential only: negative serum pregnancy test done =< 7 days prior to registration Four months post liver transplant Exclusion Criteria: Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements Clinically significant cardiac disease, especially history of myocardial infarction =< 6 months, or congestive heart failure (New York Heart Association [NYHA] classification III or IV) requiring use of ongoing maintenance therapy for life-threatening ventricular arrhythmias Taking strong inhibitors or strong/moderate inducers of cytochrome P450 (CYP)3A4 Strong inhibitors of CYP3A4/5; > 5-fold increase in the plasma area under the curve (AUC) values or more than 80% decrease in clearance Clarithromycin (Biaxin®, Biaxin XL®) Conivaptan (Vaprisol®) Grapefruit juice Itraconazole (Sporanox®) Ketoconazole (Nizoral®) Mibefradil Nefazodone (Serzone®) Posaconazole (Noxafil®) Telaprevir (Incivek®) Telithromycin (Ketek®) Use of the following inducers are prohibited =< 7 days prior to registration Strong inducers of CYP3A4/5; > 80% decrease in AUC Avasimibe Carbamazepine (Carbatrol®, Epitol®, Equetro™, Tegretol®, Tegretol-XR®) Phenytoin (Dilantin®, Phenytek®) Rifampin (Rifadin®) St. John's wort Moderate inducers of CYP3A4/5; 50-80% decrease in AUC Bosentan (Tracleer®) Modafinil (Provigil®) Nafcillin Phenobarbital (Luminal®) Rifabutin (Mycobutin®) Troglitazone Any of the following prior therapies: Chemotherapy =< 4 weeks prior to registration Mitomycin C/nitrosoureas =< 6 weeks prior to registration Immunotherapy =< 4 weeks prior to registration Biologic therapy =< 4 weeks prior to registration Radiation therapy =< 4 weeks prior to registration Radiation to > 25% of bone marrow prior to registration Failure to fully recover from acute, reversible effects of prior surgery or chemotherapy regardless of interval since last treatment Any of the following because this study involves cytotoxic agents Pregnant women Nursing women Men or women of childbearing potential who are unwilling to employ adequate contraception Other concurrent chemotherapy, immunotherapy, radiotherapy, or any ancillary therapy considered investigational (utilized for a non-Food and Drug Administration [FDA]-approved indication and in the context of a research investigation) Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens Immunocompromised patients (other than that related to the use of corticosteroids) including patients known to be human immunodeficiency virus (HIV) positive with low cluster of differentiation (CD)4 count; Note: previous calcineurin inhibitor or previous sirolimus use allowed Current active other malignancy, except non-melanoma skin cancer or carcinoma-in-situ of the cervix; if there is a history of prior malignancy, they must not be receiving other specific treatment (other than hormonal therapy) for their cancer Current impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of sirolimus (e.g., active ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome or small bowel resection) Current severely impaired lung function (i.e., forced expiratory volume in 1 second [FEV1] < 1 liter) Received immunization with attenuated live vaccines =< 7 days prior to study entry or during study period; NOTE: Close contact with those who have received attenuated live vaccines should be avoided during treatment with sirolimus; examples of live vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette-Guérin (BCG), yellow fever, varicella and typhoid (TY)21a typhoid vaccines Current severe hepatic impairment; Note: A detailed assessment of hepatitis B/C medical history and risk factors must be done at screening for all patients; hepatitis B virus (HBV) deoxyribonucleic acid (DNA) and hepatitis C virus (HCV) ribonucleic acid (RNA) polymerase chain reaction (PCR) testing are required at screening for all patients with a positive medical history based on risk factors and/or confirmation of prior HBV/HCV infection

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Treatment (cisplatin, gemcitabine hydrochloride, sirolimus)<br>Patients receive cisplatin IV over 1 hour and gemcitabine hydrochloride IV over 30 minutes on days 1 and 8, and sirolimus PO daily or three times weekly. Treatment repeats every 3 weeks for up to 8 courses in the absence of disease progression or unacceptable toxicity. | Drug: Cisplatin<br>* Given IV<br>* Other names: Platosin;Drug: Gemcitabine Hydrochloride<br>* Given IV<br>* Other names: LY-188011;Other: Quality-of-Life Assessment<br>* Ancillary studies<br>* Other names: Quality of Life Assessment;Drug: Sirolimus<br>* Given PO<br>* Other names: WY-090217;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of patients who are able to complete therapy |  | Up to 6 months post-registration |