Reflux in Spinal Cord Injury Patients With Neurogenic Lower Urinary Tract Dysfunction

Study Overview
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Brief Summary
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The purpose of this study is to investigate the incidence of reflux in patients with spinal cord injury in relation to the lesion level, duration of injury and bladder management

Detailed Description
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Vesico-ureteral reflux was the main cause for renal failure and reduced life expectancy in patients with neurogenic bladder dysfunction due to spinal cord injury. Neurogenic detrusor overactivity leads to high intravesical pressure and may induce reflux. Decreasing intravesical pressure and increasing bladder capacity is necessary to prevent reflux and secondary renal failure.

Official Title
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Vesico-ureteral Reflux in a Contemporary Series of Spinal Cord Injury Patients With Neurogenic Lower Urinary Tract Dysfunction

Conditions
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Vesico-ureteral Reflux, Spinal Cord Injury

Intervention / Treatment
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* Procedure: video-urodynamic examination


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Spinal cord injury Neurogenic lower urinary tract dysfunction Written informed consent Exclusion Criteria: Lower urinary tract dysfunction due to other causes than spinal cord injury

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Spinal cord injury<br>Patients with neurogenic lower urinary tract dysfunction due to spinal cord injury with regular urodynamic examination | Procedure: video-urodynamic examination<br>* Assessment of bladder function during video urodynamic determine of incidence degree and localization of vesico ureteral reflux based on the result of video urodynamics<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence and degree of vesico ureter renal reflux | video urodynamic, ultrasound examination | average: yearly scheduled control | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pdet (cmH2O) | urodynamic parameter, detrusor pressure | average: yearly scheduled control | 
| Medication | name of drugs and applied dosis | average: yearly scheduled examination | 
| possible complications | urinary tract infection, pyelonephritis, renal dysfunction | average: yearly scheduled examination | 
| maximum cystometric capacity | the volume at which a patient, with normal sensation, fells he/she can no longer delay micturition | average: yearly scheduled control | 
| compliance mL/cmH2O | Compliance is the change in volume divided by change in detrusor pressure expressed as mL/cmH2O. | average: yearly scheduled control | 
| bladder management | most common: intermittent catheterisation, indwelling catheter, external condom urinal for male patients | average: yearly scheduled control | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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vesico-ureteral reflux, neurogenic bladder dysfunction, spinal cord injury