Dexmedetomidine Adjuvant in Retinal Surgery

Study Overview
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Brief Summary
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During LA in retinal surgery there is some problem as regard the lack of anaesthesia duration and unexpected globe movement .so many adjuvant was added to LA to overcome this disadvantages of LA such as clonidine and fentanyl . The investigators hypothesis is adding dexmedetomidine to pribulbal blocking LA will prolong anaesthesia duration and improve globe akinesia and decrease intraoperative supplementation of LA.There are Many studies had described the effects of dexmedetomidine on peripheral nerve blocks, spinal but up to date no knowledge is available on the impact of dexmedetomidine adjuvant to local anaesthetic in ophthalmic surgery

Official Title
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DEXMEDETOMIDINE ADJUVANT TO LOCAL ANAESTHESIA FOR PERIBULBAR BLOCKS IN RETINAL SURGERY

Conditions
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Peribulbar Anesthesia

Intervention / Treatment
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* Drug: DEXMEDETOMIDINE


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patients Going for elective vitreoretinal surgery. Exclusion Criteria: History of coagulation abnormalities. Allergy to local anesthetics. Cardiac, hepatic or renal failure, Chronic clonidine or analgesic therapy. One-eyed patients

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 5 micron dex arm<br> | Drug: DEXMEDETOMIDINE<br>* Does adding 5 or 10 micron of DEXMEDETOMIDINE to peribulbar anesthesia is any different from regular peribulbar anesthesia practice?<br>|
| Experimental: 10 micron dex arm<br> | Drug: DEXMEDETOMIDINE<br>* Does adding 5 or 10 micron of DEXMEDETOMIDINE to peribulbar anesthesia is any different from regular peribulbar anesthesia practice?<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| onset, duration of the motor and sensory block | A block was considered satisfactory when complete akinesia occurred. In the absence of complete akinesia in any direction after 10 min, supplementary anesthesia given by a further injection of 2-4 ml of the test solution in the same manner as given before. Calculate the number of patients needed supplemental block were. The surgeon assessed the duration of surgery anesthesia and akinesia. Intraocular pressure measured before block, immediately after block and before surgical procedures | 10 minutes from injection | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| observe the adverse effects of Dexmedetomidine | ECG, invasive BP and pulse oximetry will apply to all patients. • The haemodynamic parameters (MAP and HR) will be continuously measured, and will be recorded at before induction (baseline), one minute after block . after 5 minutes then at the surgical incision, 15-min intervals intraoperatively, the end of surgery and10 and 20 minutes postoperatively. Incidence of Oculocardiac reflex (OCR) or any arrhythmia during surgery. | during and after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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local anesthesia, peribulbar anesthesia, DEXMEDETOMIDINE, vitreoretinal surgery