Assessment of Proprioceptive and Functional Characteristics in Patients With Hemophilia

Study Overview
=================
Brief Summary
-----------------
Analyze and evaluate the skeletal muscle of patients affected with hemophilia in the Region of Murcia. Describe the periarticular muscular deficit of the lower limbs, depending on the degree of injury: acute and chronic, or subacute. Identify the range of motion of joints with higher prevalence of hemophilic arthropathy. Detect the biomechanical changes of the lower limbs and their impact on gait in patients with hemophilia. Assess the factors that influence the perception of illness and quality of life of patients with hemophilia.

Detailed Description
-----------------
Descriptive study of joint involvement in hemophilia patients with and without a history of hemarthrosis in lower limbs. Descriptive study of alterations in the strength of the periarticular muscles of lower limbs as a result of acute conditions or the development of chronic articular sequelae. Descriptive study of the biomechanical alterations in weight-bearing joints of lower limbs and their impact on gait in patients with hemophilia. Descriptive study of the relationship between skeletal muscle pathology in patients with hemophilia and their perceptions of it and their quality of life.

Official Title
-----------------
Assessment and Identification of Proprioceptive and Functional Changes in Patients With Hemophilia of the Region of Murcia.

Conditions
-----------------
Hemophilia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with hemophilia A and B Patients of all ages (from 6 to 70 years). With or without joint damage clinically diagnosed, and with or without a previous history of hemarthrosis joint load legs. Residents in the Autonomous Community of the Region of Murcia. Exclusion Criteria: Patients without ambulation Patients diagnosed with other congenital coagulopathy (von Willebrand disease, etc..). Patients with neurological or cognitive impairments that prevent understanding the questionnaires and physical tests.

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with hemophilia<br>Patients with hemophilia who meet the inclusion criteria | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assess the range of motion | Assess the range of motion of elbow, knee and ankle (using a goniometric evaluation). | Screening visit | 
| Assess the muscular strength | Assess the muscular strength of arm, thigh and leg (through measurement of muscle balance). | Screening visit | 
| Assess the joint pain | Joint pain (VAS scale with the use of a pressure algometer). | Screening visit | 
| Assess the variables of strength | Assessment of variables of vertical strength, medio-lateral and anterior-posterior in jump and incorporation from the sitting position. | Screening visit | 
| Assess the peak force | Functional assessment of peak force, force production per unit time and subsequent stabilization in standing (in jump and in the passage from the sitting position to standing position, respectively, using a force platform). | Screening visit | 
| Assess the contractile activity | Assessment of miotendinous contractile activity in the patellar tendon and Achilles, in jump (CMJ-stiffness test). | Screening visit | 
| Assess the state joint | State joint (applying Hemophilia Joint Health Score questionnaire). | Screening visit | 
| Assess the list of activities | List of activities in hemophilia (completing the autocuestionario Hemophilia Activities List). | Screening visit | 
| Assess the physical performance | Perception of physical performance (with the HEP-Test-Q questionnaire) | Screening visit | 
| Assess the health Profile | Health Profile (using the scale Nottingham health profile) | Screening visit | 
| Assess the quality of life | Quality of life (using the SF-36 and Haemo-QoL-36 questionnaire). | Screening visit | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Age, sex, weight of the patients with hemophilia |  | Screening visit | 
| Diagnosis, severity of hemophilia, type of treatment (prophylactic or on-demand) and inhibitors |  | Screening visit | 
| Frequency of joint bleeds in the previous month and bleeding during the assessment |  | Screening visit | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hemophilia, Arthropathy, Range of Motion, Strength, Proprioception, Gait, Quality of Life