Hypercortisolism and Epicardial Adipose Tissue

Study Overview
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Brief Summary
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Identifying hypercortisolism patients at risk for cardio-vascular events despite biological cure, and determine which patients should be particularly followed. Hypercortisolic patients represent an ideal in vivo model to determine the interactions between glucocorticoids and ectopic fat development.

Official Title
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Impact Hypercortisolism on Adipose Epicardial and on Myocardial Function

Conditions
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Hypercortisolism

Intervention / Treatment
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* Biological: Blood samples for measuring adiponectin, leptin and omentin plasma
* Device: MRI at 3 Tesla


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Major, male or female Introducing an active or healed hypercortisolism caused by Cushing's disease signed informed consent. Exclusion Criteria: Elderly patients under 18 years Pregnant or lactating women Previous history of myocardial infarction Antecedent congenital cardiomyopathy Adrenocorticotropic hormone-independent Hyperadrenocorticism Hyperadrenocorticism by ectopic Adrenocorticotropic hormone secretion Treatment with corticosteroids or insulin Specific contraindication to the achievement of Nuclear Magnetic Resonance (metal heart valves, pacemakers, metallic foreign body, claustrophobia) Persons deprived of liberty Persons not affiliated to a social security scheme People unable to give their consent in writing (in person or with the assistance of a third party).

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: patients with active hypercortisolism<br> | Biological: Blood samples for measuring adiponectin, leptin and omentin plasma<br> <br> Device: MRI at 3 Tesla<br>* Evaluation by MRI at 3 Tesla of the amount of ectopic fat heart, liver and pancréas and bone marrow.<br>|
| Active Comparator: Patients in remission of their hypercortisolism after surgery<br> | Biological: Blood samples for measuring adiponectin, leptin and omentin plasma<br> <br> Device: MRI at 3 Tesla<br>* Evaluation by MRI at 3 Tesla of the amount of ectopic fat heart, liver and pancréas and bone marrow.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| measuring the volume of epicardial adipose tissue, as measured by MRI to 3 Tesla. |  | 36 months | 
| Assess insulin resistance by the blood sugar and insulin levels |  | 36 months | 
| Assess cardiovascular risk by a blood complete lipid profile |  | 36 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assess insulin resistance by the blood leptin, adiponectin and omentin plasma level |  | 36 months | 
| Assess cardiovascular risk by the blood leptin, adiponectin and omentin plasma level |  | 36 months |