Adductor-Canal-Blockade Versus the Femoral Nerve Block Effect on Muscle Strength, Pain and Mobilization After Total Knee Replacement

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to investigate the efficacy of the Adductor-Canal-Blockade versus the Femoral Nerve Block on muscle strength, pain and mobilization after total knee arthroplasty. We hypothesize that the Adductor-Canal-Blockade has the same effect on pain and morphine consumption as the Femoral Nerve Block, but without the same reduction in quadriceps muscle strength.

Official Title
-----------------
A Comparison of the Efficacy of the Adductor-Canal-Blockade Versus the Femoral Nerve Block on Muscle Strength, Pain and Mobilization After Total Knee Arthroplasty: a Randomized Study

Conditions
-----------------
Total Knee Arthroplasty

Intervention / Treatment
-----------------
* Procedure: Adductor-Canal-Blockade
* Procedure: Femoral Nerve Block


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: ASA 1-3 BMI > 18 og < 40 total knee arthroplasty in spinal anesthesia Exclusion Criteria: Can not cooperate to the exam Do not speak or understand Danish Drug allergy Alcohol or drug abuse Daily consumption of strong opioids Rheumatoid arthritis Intake of glucocorticoids Effect of spinal anesthesia stopped prior to performing the regional block

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Adductor-Canal-Blockade<br> | Procedure: Adductor-Canal-Blockade<br>* US-guided Adductor-Canal-Blockade with Ropivacaine<br>|
| Active Comparator: Femoral Nerve Block<br> | Procedure: Femoral Nerve Block<br>* US-guided Femoral Nerve Block with Ropivacaine<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The difference in quadriceps muscle strength between the Adductor-Canal-Blockade and the femoral nerve block |  | 24 h postoperatively | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The difference in adductor muscle strength between the Adductor-Canal-Blockade and the Femoral Nerve Block |  | 24 h postoperatively | 
| Pain during flexion of the knee | 0-100 mm at a visual analogue scale (VAS), calculated as the area under the curve for the interval 2-24 hours postoperatively. | 2-24 hours | 
| Pain at rest | 0-100 mm at a visual analogue scale (VAS), calculated as the area under the curve for the interval 2-24 hours postoperatively. | 2-24 hours | 
| Total morphine consumption |  | 0-24 hours | 
| Postoperative nausea |  | 2-24 hours | 
| Postoperative vomiting |  | 0-24 hours | 
| Sedation |  | 2-24 hours | 
| Zofran consumption | Number of patients recieveing zofran postoperatively | 0-24 hours | 
| The difference in mobilization between the groups |  | 24 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Adductor-Canal-Blockade, Femoral Nerve Block, Postoperative Pain, Total Knee Arthroplasty