Bayesian Estimation of Diagnostic Performance for Cardiovascular Autonomic Neuropathy

Study Overview
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Brief Summary
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This study aimed to evaluate the reference values for the short-term heart rate variable (HRV), estimate the performance of cardiovascular autonomic neuropathy (CAN) diagnostic tests in the absence of a gold standard, and assess CAN prevalence in our cross-sectional dataset.

Detailed Description
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The CAN prevalence is rapidly growing in all populations worldwide. No document has been reported about normal reference values for CAN using this test in the Chinese population. This study aimed to evaluate the reference values for the short-term HRV in a large cross-sectional dataset, and to estimate sensitivities and specificities of CAN diagnostic tests using the Bayesian approach, in the absence of a gold standard in another independence dataset. Finally, CAN prevalence was estimated in the investigators' cross-sectional dataset. Firstly, the reference the values for the short-term HRV were calculated in the investigators' previous study (including 371 healthy subjects). This study dataset contained 88 subjects who completed both the short-term HRV test and Ewing's test. Simultaneous inferences about the population prevalence and the performance of each diagnostic test were possible using the Bayesian approach without a gold standard.

Official Title
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Bayesian Estimation of Diagnostic Performance of Short-term Heart Rate Variability for Cardiovascular Autonomic Neuropathy Without a Gold Standard

Conditions
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Diagnostic Performance of Cardiovascular Autonomic Neuropathy

Intervention / Treatment
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* Other: not intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Survey participants with undiagnosed CAN, aged 30-80 years, were included in this study. Exclusion Criteria: Some subjects were excluded from the study to eliminate potential confounding factors that may have influenced their CA function 11. Briefly, the exclusion criteria were as follows: history or findings of arrhythmia, and hyperthyroidism or hypothyroidism; pregnancy or lactation; and/or serious hepatic or renal dysfunctions.

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Dr.Tang's research group<br>This group included participants with completed both the short-term HRV test and Ewing's test. | Other: not intervention<br>* This is a cross-sectional study for estimation of diagnostic performance.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiovascular autonomic function evaluate by short-term heart rate variability test | Both short-term heart rate variability and Ewing's test measure cardiovascular autonomic function | participants will be measured for the duration of outpatient stay, an expected average of two days | 
| Cardiovascular autonomic function evaluate by Ewing's test | Both short-term heart rate variability and Ewing's test measure cardiovascular autonomic function | participants will be measured for the duration of outpatient stay, an expected average of two days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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diagnostic performance, Bayesian estimation, short-term heart rate variability, cardiovascular autonomic neuropathy