Fournier's Gangrene and the Origin of the Infection as a Prognostic of Morbidity and Mortality, an Analysis of 121 Patients

Study Overview
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Brief Summary
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Background: Fournier's gangrene it's a necrotizing infection of the genital area, with high morbidity and mortality. The site of infection its the origin of the necrotizing fasciitis. There are 4 well known origins of Fournier's gangrene: Testicular, Intestinal, Urinary and cutaneous, and its prognostic value has not been established yet, that's because the lack of case series with adequate number of patients. This is a retrospective study in which we evaluate the prognostic factors of every patient and its mortality compared with its origin area and multiple scores with their survival rates and hospital stay.

Detailed Description
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Objective: To evaluate origins of Fournier's gangrene as a prognostic value in the morbidity and mortality. Patients and methods: This is a retrospective study where patients from a single hospital from 2007 to 2016 were included. They were categorized in 4 groups matching the origin of infection. In every group categorizing with the origin of infection and determined severity factors, days of hospital stay, Fournier's gangrene severity index and mortality. A statistic analysis will be done using lineal multivariable analysis.

Official Title
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Fournier's Gangrene and the Origin of the Infection as a Prognostic of Morbidity and Mortality, an Analysis of 121 Patients

Conditions
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Fournier Gangrene, Fournier's Gangrene of Penis, Fournier's Gangrene of Scrotum

Intervention / Treatment
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* Procedure: Aggressive debridement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria Male Patient Fournier's Gangrene All patients treated with two antibiotics All patients undergone with aggressive debridement Exclusion Criteria Female Not having Fournier's Gangrene
Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Intestinal origin<br>Either perianal abcess or rectal carcinoma | Procedure: Aggressive debridement<br>* Aggressive debridement of the tissues undergoing fascitis<br>|
| Testicular Origin<br>Complicated epididymitis with fascitis, | Procedure: Aggressive debridement<br>* Aggressive debridement of the tissues undergoing fascitis<br>|
| Urinary Origin<br>From urinary tract infection or fistulae from urethral trauma | Procedure: Aggressive debridement<br>* Aggressive debridement of the tissues undergoing fascitis<br>|
| Cutaneous Origin<br>mostly folliculitis, and skin infections | Procedure: Aggressive debridement<br>* Aggressive debridement of the tissues undergoing fascitis<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fournier's Gangrene Severity Index | A score to predict mortality in this kind of patients | 0-24 hours | 
| Hospital stay ( in days) | The patients hospital stay | 0 to 2 months | 
| Couture | Positive or negative couture and the bacterias growing in the abscess | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diabetes mellitus | if the patient had diabetes mellitus type 2 or not | 0 - 100 years | 
| Hypertension | if the patient had arterial hypertension or not | 0 - 100 years | 
| Alcohol drinking | if the patient drinks alcohol or not | 0 - 100 years | 
| Tobacco smoking | if the patient smokes or not | 0 - 100 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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fournier's, gangrene