Effects of Aloe Vera Toothpaste on Periodontal Parameters

Study Overview
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Brief Summary
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This study aimed to assess the effects of Aloe Vera toothpaste on dental plaque and gingivitis. The single-blind cross-over clinical trial was conducted on 20 dental students (10 males and 10 females with a mean age of 24.5±4 yrs.) with gingivitis. Students were randomly divided into 2 groups. The first group used Aloe Vera toothpaste for 30 days. A 2-week wash-out period was allowed and then subjects used fluoride toothpaste for the next 30 days . This order was reversed in group 2.

Detailed Description
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Toothpastes are used with tooth brushing to better control microbial plaque. Herbal toothpastes have recently gained attention. This study aimed to assess the effects of Aloe Vera toothpaste on dental plaque and gingivitis. This single-blind cross-over clinical trial was conducted on 20 dental students (10 males and 10 females with a mean age of 24.5±4 yrs.) with gingivitis. Students were randomly divided into 2 groups. The first group used Aloe Vera toothpaste for 30 days and then their plaque index (PI) and gingival index (GI) were recorded. A 2-week wash-out period was allowed and then subjects used fluoride toothpaste for the next 30 days and underwent PI and GI assessment again. This order was reversed in group 2. Wilcoxon-Sign Rank and two way Repeated Measure ANOVA tests were applied for statistical analysis.

Official Title
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Effects of Aloe Vera Toothpaste on Periodontal Parameters of Patients With Gingivitis

Conditions
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Gingivitis

Intervention / Treatment
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* Other: Foramen Herbal Aloe toothpaste
* Other: fluoride toothpaste


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects were selected among dental students with at least 20 natural teeth without systemic disease No periodontal treatment at least 6 months to the study No use of systemic antibiotic and anti-inflammatory drugs within the last 3 months, nonsmokers, no pregnancy or lactating women Subjects with PD≤3mm, (clinical attachment level)CAL<1mm, PI≥2 and gingival bleeding in more than 30% of the tested areas were enrolled with the diagnosis of plaque-related gingivitis. Exclusion Criteria: Subjects with orthodontic appliances ,multiple bridges, partial denture, multiple caries were excluded from the study

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 24 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Foramen Herbal Aloe toothpaste<br>test group was asked to brush the teeth with Foramen Herbal Aloe toothpaste for 30 days once a day. | Other: Foramen Herbal Aloe toothpaste<br>* use of aloe-vera toothpaste for 30 days in the test group.<br>|
| Active Comparator: use of fluoride toothpaste (signal)<br>use of a fluoride toothpaste (signal) in control group once a day for 30 days . | Other: fluoride toothpaste<br>* use of signal toothpaste once a day for 30 days in the control group.<br>* Other names: signal;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| measuring gingival index | to compare the efficacy of the aloe-vera toothpaste with a known conventional toothpaste, the gingival index was recorded at baseline and after 30 days of consumption and compared with the two understudy toothpastes. | 1-2days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| measuring gingival index | to compare the efficacy of the aloe-vera toothpaste with a known conventional toothpaste, the gingival index was recorded at baseline and after 30 days of consumption and compared with the two understudy toothpastes. | 1-2 days | 
| measuring plaque index | to compare the efficacy of the aloe-vera toothpaste with a known conventional toothpaste, the plaque index was recorded at baseline and after 30 days of consumption and compared with the two understudy toothpastes. | 1-2 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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clinical trial, oral hygiene, Gingivitis, Aloevera, Toothpaste, anti-inflammatory agents