Developmental Language Difficulties: Behavioural and Electrophysiological Studies

Study Overview
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Brief Summary
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This study will help to better characterize oral and written language disorders and determine if these disorders are continuous or not. The participants ( dyslexic and dysphasic patients and control adults) will carry out an auditory lexical decision task during which an electroencephalogram (EEG) will be recorded.

Official Title
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Developmental Language Difficulties: Behavioural and Electrophysiological Studies of the Connections Between Spoken and Written Language and Specificity of These Disorders

Conditions
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Dyslexia, Dysphasia

Intervention / Treatment
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* Behavioral: auditory lexical decision task
* Device: electroencephalogram


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria (patients): Non-verbal intelligence quotient (IQ) less than 85 according to the Wechsler Intelligence Scale for Children (WISC) perceptual index Specific oral language disorders diagnosed by the multidisciplinary team (neurologist, psychologist, speech therapist): understanding language deficit, estimated by the test SCOTLAND (Lecocq, 1996) and / or vocabulary test (Dunn Thiébaud). Specific written language disorders (dyslexia) diagnosed by a multidisciplinary team according to a test that can objectify the late reading (Alouette) and locate deficits (EVALEC) Be affiliated to a social security regimen Have signed an informed consent or signed by the parents if the patient is minor Aged at least 8 years old Inclusion Criteria (controls) Non-deficit (>85) non-verbal Wechsler Scale (codes and matrices) No specific oral language disorders No specific written language disorders (dyslexia) Be affiliated to a social security regimen Have signed an informed consent or signed by the parents if the patient is minor Aged at least 8 years old Exclusion Criteria: Mother tongue other than French Non-verbal reasoning abilities below 85 measured by the WISC 4 (for patients only) and Non-verbal capacities of reasoning lower than the normal measured by the non-verbal scale of Wechsler (for controls only) Presence of pervasive developmental disorders No affiliation to a social security regimen Absence of signature of the informed consent Subject of less than 8 years

Ages Eligible for Study
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Minimum Age: 8 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control adults<br>lexical tests and electroencephalogram (EEG). | Behavioral: auditory lexical decision task<br> <br> Device: electroencephalogram<br> <br> |
| Dyslexic patients<br>lexical tests | Behavioral: auditory lexical decision task<br> <br> Device: electroencephalogram<br> <br> |
| Dysphasic patients<br>lexical tests | Behavioral: auditory lexical decision task<br> <br> Device: electroencephalogram<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Score Alouette reading test | In this test, the participant has to read in a loud voice a text, during three minutes. The final score takes into account the speed and the number of errors. For test performance, clinical groups will be compared with its controls. | at inclusion | 
| Score EVALEC reading test | For test performance, clinical groups will be compared with its controls. | at inclusion | 
| Score silence reading test | A group of letters will be presented and the participant has to say if this letters compose a known word. For test performance, clinical groups will be compared with its controls. | at inclusion | 
| Score of reading comprehension test | For test performance, clinical groups will be compared with its controls. | at inclusion | 
| Score of Khomsi | The objective of this group of different tests is to evaluate comprehension and production of oral language. For test performance, clinical groups will be compared with its controls. | at inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measure of the electroencephalography power spectra | For test performance, clinical groups will be compared with its controls. | at inclusion | 
| Correlation between electroencephalography power spectra and clinical outcome | For test performance, clinical groups will be compared with its controls. | at inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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language disorders, developmental disorders of oral and written language