A Contribution to the Analysis of the Phenotypic Heterogeneity in Crack/Cocaine Addiction : a Case Control Study

Study Overview
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Brief Summary
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The purpose of this study is to assess the phenotypic candidates symptoms, in patients with crack/cocaine addiction, in terms of clinical comorbidities, dimensions of personality, and neuropsychological evaluations apt to be associated with genetic and genotypic characterisations, notably on the polymorphisms of the genes coding or regulating dopaminergic, norepinephrine and serotoninergic systems.

Detailed Description
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Genetic studies show an association between drug addiction and the dopaminergic system and its modulators. Nonetheless, results are contradictory, partially due to the heterogeneity of the phenotype addiction. Placed on the trafficking route of cocaine, and homogeneously populated, Martinique is of particular interest for the study of the vulnerability of the crack/cocaine addiction. In a precedent study, supported by a grant MILDT / INSERM 2000, on 155 men dependent to crack/cocaine and characterised with three clinical dimensions -sensation seeking, impulsivity and childhood ADHD- we found an association between each dimension and polymorphisms of DRD2 and DRD4 genes.

Official Title
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A Case Control Study on Contribution to the Analysis of the Phenotypic Heterogeneity in Crack/Cocaine Addiction

Conditions
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Dependence, Cocaine

Intervention / Treatment
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* Genetic: Collect 10 ml of Saliva for DNA extraction


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis of cocaine abuse/dependence according to DSM-IV-TR criteria Come from French West Indies (3 grandparents are African-Caribbean) Sign a written informed consent Exclusion Criteria: Minor Men with no cocaine abuse/dependence according to DSM-IV-TR criteria For the control: Inclusion Criteria: Platelets donor No substance abuse/dependence according to DSM-IV-TR criteria Come from French West Indies (3 grandparents are African-Caribbean) Sign a written informed consent Exclusion Criteria: Minor Men refusing a genetic study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Genetic: Collect 10 ml of Saliva for DNA extraction|After signed written informed consent, all patients and controls have clinical and neuropsychological evaluations (DIGS, WURS, BROWN, BIS, SSS and IGT) for phenotypic diagnosis and collection of saliva for DNA extraction and genotyping diagnosis.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The specific measure that will be related to core objectives of the study is to constitute a sample collection from saliva. |  | The saliva will be collect at the end of the first visit | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Diagnosis of dependence on cocaine according to DSM-IV-TR criteria