Risk Analysis for Cardiovascular Autonomic Neuropathy

Study Overview
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Brief Summary
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This is a large-scale, community-based, cross-sectional study to evaluate environmental and genetic risk factors for cardiovascular autonomic neuropathy in general Chinese population.

Detailed Description
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A large-scale, community-based, cross-sectional study was conducted to explore the extent to which risk factors associated with cardiovascular autonomic neuropathy (CAN) in general Chinese population. A total of more than 2000 participants were recruited by using multiple stages sampling (first cluster sampling and then simply sampling). Data involved in demographic information, clinical biomarkers such as glucose and lipids profiles, medical and therapy history were collected. Every participants was complete DNA extracted and genotyped. Cardiovascular autonomic functions were measured by using short-term heart rate variability (HRV) to evaluate the outcome of CAN. Univariate and multiple variables analysis have been performed to examine potential environmental and genetic risk factors of CAN. In addition, clinical risk model, simply screening model and non-linear system model such as artificial neural network was created, respectively.

Official Title
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The Risk Analysis for Cardiovascular Autonomic Neuropathy in General Chinese Population

Conditions
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Cardiovascular Autonomic Neuropathy

Intervention / Treatment
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* Other: not intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Survey Chinese participants with undiagnosed CAN Aged 30-90 years, were included in this study. Exclusion Criteria: Some subjects were excluded from the study to eliminate potential confounding factors that may have influenced their CA function. Briefly, the exclusion criteria were as follows: history or findings of arrhythmia and hyperthyroidism or hypothyroidism pregnancy or lactation serious hepatic or renal dysfunctions (GFR < 30 mL/min/1.73m2). Of these subjects, complete baseline data were obtained for 2,092 (69.46%) of the participants.

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Dr.Tang's research group<br>Dr.Tang's research group for clinical risk analysis of human complex disease | Other: not intervention<br>* This is a cross-sectional study, no intervention was performed.<br>* Other names: This is a cross-sectional study, no intervention was performed.;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cardiovascular autonomic neuropathy (CAN) measured by short-term heart rate variability (HRV) |  | participants will be measured for the duration of outpatient stay, an expected average of 2 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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risk analysis, general Chinese population, cardiovascular autonomic neuropathy