Posterior Maxillary Ridge Augmentation With Sinus Lift Using Mineralized Plasmatic Matrix Versus Autogenous Bone Graft

Study Overview
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Brief Summary
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Using growth factors obtained from patient's venous blood mixed with particulate autogenous bone the study compares bone gain by implant with gold standards in sinus Lift procedures for future implant insertion.

Detailed Description
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To study the effectiveness of MPM in ridge augmentation with implant insertion compared with autogenous bone graft. -PICO Population(P) : Patients with defective posterior maxillary alveolar ridge. Intervention (I) :Implant placement and ridge augmentation with MPM. Comparator (C) : Autogenous bone graft. Outcome (O) : Patient satisfaction - Implant stability.

Official Title
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Posterior Maxillary Ridge Augmentation With Sinus Lift Using Mineralized Plasmatic Matrix Versus Autogenous Bone Graft (A Randomized Clinical Trial Comparative Study)

Conditions
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Bone Resorption

Intervention / Treatment
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* Other: autogenous bone
* Other: Mineralized plasmatic matrix


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients systemically free. Patients with posterior maxillary defective ridges indicated for sinus lift procedure. Cases with 5 mm bone height or less are included in the study. Age between 18 and 50 years. Both sexes. Patients physically able to tolerate surgical and restorative procedures. Good oral hygiene. Highly motivated patients. Exclusion Criteria: Patients allergic to local anesthetic agent. Medium and heavy smokers. Pregnant females. Presence of any pathosis in the pre-implant site. Presence of any mucosal disease. History of oral radiotherapy. History of prolonged steroids use. Psychological disorders.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Autogenous bone graft (Gold Standard).<br>Patients with defective posterior maxillary alveolar ridges requiring implant insertion will have Autogenous bone graft (Gold standard) and to be used for bone augmentation with sinus lift. | Other: autogenous bone<br>* Autogenous bone graft (gold standard). sinus lift with autogenous bone.<br>* Other names: Autobone;|
| Experimental: Mineralized Plasmatic Matrix (MPM)<br>Patients with defective posterior maxillary alveolar ridges requiring implant insertion will receive bone graft using Mineralized plasmatic matrix. | Other: Mineralized plasmatic matrix<br>* By using venoud blood from the patient, together with bone graft, a centrifuge will be used to obtain the top layer after centrifuging blood at 3000 RPM.<br>* Other names: MPM;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient Satisfaction regarding aesthetic results will be measured using questionnaire. | outcome will be measure using questionnaire. | 9 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Stability of dental implants. | will be measured using OSTELL Device. | 5 months |