Assessing the Stability of Transcranial Magnetic Stimulation Plasticity Responses

Study Overview
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Brief Summary
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The overall goal of this proposed study is to assess the reliability of plasticity measured by transcranial magnetic stimulation (TMS) interleaved with intermittent theta-burst stimulation plasticity measures and to assess the influence of an acute bout of aerobic exercise on TMS plasticity measures.

Official Title
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Assessing the Reliability and Influence of Timing of Exercise on Transcranial Magnetic Stimulation (TMS) Neuroplasticity Measures

Conditions
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Healthy

Intervention / Treatment
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* Behavioral: Short-term aerobic exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult males and females aged 18-70 years old. Primary language is English Exercise clearance Exclusion Criteria: Presence of cognitive, neurologic or orthopedic conditions that could affect performance of the testing and training procedures History of migraines History of fainting spells of unknown or undetermined etiology that might constitute seizures History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or family history of treatment resistance epilepsy Any current history of psychiatric illness Any unstable medical condition No medication is an absolute exclusion from TMS. Medications will be reviewed by the Principal Investigator and a decision about inclusion will be made based on the following: The subject's past medical history, drug does, history of recent medication changes or duration of treatment, and combination with other central nervous system active drugs. The published TMS guidelines review medications to considered with TMS (Rossi, Hallet, Rossini, Pascual-Leone, & Safety of TMS Consensus Group, 2009) Any metal in the brain, skull or elsewhere unless approved by the responsible MD Any medical devices (i.e. Cardiac pacemaker, deep brain stimulator, medication infusion pump, cochlear implant, vagal nerve stimulator) Intracranial lesion Substance abuse or dependence within the past six months

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Short-term aerobic exercise<br>One bout of moderate intensity exercise (75% of maximal predicated heart rate). | Behavioral: Short-term aerobic exercise<br>* One bout of moderate intensity exercise (75% of maximal predicated heart rate).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in cortical synaptic plasticity | As measured via Transcranial Magnetic Stimulation (TMS) in mean motor evoked potential (MEP) amplitude | Baseline, 1 week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assess TMS plasticity measures on healthy individuals after an acute bout of exercise | As measured via Transcranial Magnetic Stimulation (TMS) in mean motor evoked potential (MEP) amplitude after an acute bout of aerobic exercise | Baseline, 3 weeks |