Complications of Pediatric Liver Transplantation

Study Overview
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Brief Summary
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Liver transplant is the treatment of choice in children with end-stage liver failure.liver transplant is indicated when the risk of mortality from the native liver disease outweighs the overall risk of transplantation.The complications occur both immediately post-transplantation and in the long-term. The main complications in the immediate postoperative period are related to the function of the graft (dysfunction and rejection), the surgical technique, infections (bacterial, fungal, and viral),and systemic problems (pulmonary, renal, or neurological) and in the long term, the complications are typically a consequence of the prolonged immunosuppressive therapy.

Detailed Description
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Liver transplant is the treatment of choice in children with end-stage liver failure. It involves the surgical removal of the entire organ, which is then replaced with a healthy donor liver. Having a healthy liver is essential to longevity because the liver is responsible for nutrient distribution and toxin removal in the body . Living-donor liver transplantation has been developed to address the disparity between the number candidates for transplant and the reduced number of available organs for liver transplantation. In general, liver transplant (LT) is indicated when the risk of mortality from the native liver disease outweighs the overall risk of transplantation. Indications for liver transplantation in children include malignant and non-malignant conditions. The complications occur both immediately post-transplantation and in the long-term. The main complications in the immediate postoperative period are related to the function of the graft (dysfunction and rejection), the surgical technique, infections (bacterial, fungal, and viral),and systemic problems (pulmonary, renal, or neurological) and In the long term, the complications are typically a consequence of the prolonged immunosuppressive therapy.

Official Title
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Early and Late Complications of Living Related Pediatric Liver Transplantation

Conditions
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Liver Transplant; Complications

Intervention / Treatment
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* Diagnostic Test: blood tests , abdominal US and doppler


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients from (1- 18) years old who were prepared for liver transplantation and followed up at Yassin Abdel Ghaffar charity center for liver disease and research,Cairo,Egypt. from January 2015 to the end of March 2020. Exclusion Criteria: Any patient who did not survive beyond the first post operative day.

Ages Eligible for Study
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Minimum Age: 1 Year
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| with complications<br>children who did liver transplantation and develop complications | Diagnostic Test: blood tests , abdominal US and doppler<br> <br> |
| without complications<br>children who did liver transplantation and do not develop complications | Diagnostic Test: blood tests , abdominal US and doppler<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hematological ,vascular and infectious complications | Number of patients have vascular complications Number of patients have pancytopenia Number of patients have bacterial viral or fungal infection any changes in septic screen of the patient | 5 years |