linjc16/ctgov huggingface dataset:
Long-term Effects of Laser Refractive Surgery

Study Overview
=================
Brief Summary
-----------------
This study will determine if there are short- and long-term postoperative differences in visual and corneal outcomes between different laser refractive surgical procedures.

Detailed Description
-----------------
We will measure postoperative differences in visual acuity, contrast sensitivity, corneal light scatter, density of keratocytes and subbasal nerves, corneal sensitivity, corneal topography and wavefront between PRK performed with epithelial removal by a laser or by a rotary brush and between LASIK performed by using a microkeratome or by using a femtosecond laser. Measurements will be made at baseline and at intervals over 5 postoperative years in 21 LASIK patients, 20 PRK patients, and 20 unoperated controls.

Official Title
-----------------
Long-term Effects of Laser Refractive Surgery

Conditions
-----------------
Myopia

Intervention / Treatment
-----------------
* Procedure: Laser Refractive Surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Myopia 1-10 diopters No other ocular abnormalities except presbyopia

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Laser Refractive Surgery|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| keratocyte density at 5 years |  |  | 
| nerve density at 5 years |  |  |
Knee Muscle Force Recovery After Minimally Invasive Surgery (MIS) Total Knee Replacement (TKR)

Study Overview
=================
Brief Summary
-----------------
To compare muscle torque recovery between patients under subvastus approach and those under midvastus approach after total knee replacement

Detailed Description
-----------------
Total knee Arthroplasty is a common operated surgery in each hospitals, and a lots of patients benefit from this surgery. Traditionally the frequently used surgical approach is parapatellar approach. However, recently the subvastus and midvastus approach has gained a world-wide population. These two methods had less damage to the quadriceps tendon and theoretically should have better post-operative muscle power recovery, less lateral retinaculum release because of better patellar tracking. The only differences between these two approaches are that the midvastus approach will split the vastus medialis muscle and denervation may occur. In this study we will use HSS or KSS functional score and Cybex dynamometer to evaluate the functional recovery, and use Merchant's view radiography to evaluate the result of patellar tracking. The follow-up period will not be limited and we will use mixed-model statistic's random effect to gain the natural history of muscle power recovery, which will become the base of other study. We can also compare the difference of results between PS type and CR type and different surgical approach. The natural history of the knee score will also be obtained.

Official Title
-----------------
Outcome and Benefit After Total Knee Arthroplasty: Natural History of Muscle Power Recovery and Difference Between Different Surgical Approach

Conditions
-----------------
Muscle Torque, Total Knee Replacement Approach

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients after subvastus approach or midvastus approach total knee replacement Exclusion Criteria: patients with severe hypertension, heart disease or other problems which negatively influence the security of muscle test

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| subvastus approach/ midvastus approach<br>subvastus: vastus medialis oblique was not cut during operation midvastus: vastus medialis oblique was cut during operation | |
| Cybex<br>Knee extension/ flexion isometric and isokinetic performance of all cases were tested using Cybex | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Total knee replacement, Subvastus, Midvastus, Isokinetic, Quadriceps
Variability of Impedance Pneumography Tidal Breathing Flow-volume Curves During Sleep in Healthy Children

Study Overview
=================
Brief Summary
-----------------
This is an observational study for the assessment of normal overnight variation in small healthy children using the Ventica Lung Function Testing System. The study is carried out to establish reference ranges for overnight lung function variation using the Ventica test, and to assess the impact of the demographic factors on the Ventica results.

Official Title
-----------------
Variability of Impedance Pneumography Tidal Breathing Flow-volume Curves During Sleep in Healthy Children

Conditions
-----------------
Healthy Subjects

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 months-6 years, both sexes Healthy at the time of inclusion Laboratory analyses in the reference range or not clinically relevant according to the investigator judgement Lung function in the reference range with a negative bronchodilator test result Signed informed consent Exclusion Criteria: Preterm birth Chronic respiratory disorder of prematurity Recurrent bronchitis or recurrent hospitalizations because of a respiratory illness (recurrent pneumonia) Primary immunodeficiency Chronic rhinosinusitis, synonasal polyposis Nasal congestion, adenotonsillar hypertrophy, signs and symptoms of sleep apnea or sleep disordered breathing Acute respiratory infection or hospitalization because of an acute illness within 4 weeks prior to inclusion Personal or family history or clinical evidence of asthma, atopy or other chronic respiratory disorders (high risk for asthma and allergy) Use of asthma rescue or maintenance medication within 4 weeks prior to inclusion Implanted or external active medical devices such as pacemakers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Normal range of variables of tidal breathing flow-volume curves (CSRmin, NLmin, etc.) | Analyse the normal range of variables that describe the shape and variability of tidal breathing flow-volume curves during natural night sleep obtained with impedance pneumography | 1-3 nights per subject |
Membrane Shedding During Severe Sepsis and Septic Shock: Pathophysiological and Clinical Relevance

Study Overview
=================
Brief Summary
-----------------
Microparticules (MPs) result from plasma cell membrane remodeling and shedding after cell stimulation or apoptosis. MPs are know recognized as a pool of bioactive messengers with merging role in pathophysiology of immune and cardiovascular diseases. MPs have been characterized during septic shock and may contribute to dissemination of pro-inflammatory and procoagulant mediators. This a prospective observational study of circulating MPs and blood coagulation in septic shock patients admitted in medical intensive care units (ICUs) of four tertiary hospitals at baseline (D1, D2, D3, D4, D7).

Official Title
-----------------
Membrane Shedding During Severe Sepsis and Septic Shock: Pathophysiological and Clinical Relevance

Conditions
-----------------
Severe Sepsis and Septic Shock

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Septic shock (patients) Without septic shock (control) Informed consent Exclusion Criteria: Class IV heart failure Child-plugh grade C cirrhosis Cancer under active treatment BMI>35kg/m2 Moribund patient DNR decision

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients<br>patients with septic shock | |
| control<br>patients without septic shock | |
| healthy volunteers<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in number and type of circulating microparticles at 7 days |  | Baseline and 7 days | 
| Change from baseline in blood coagulation markers at 7 days |  | Baseline and 7 days |
Effect of the Side of Interscalene Block on Bradycardia and Hypotension in Beach Chair Position

Study Overview
=================
Brief Summary
-----------------
The Left interscalene block has a different effect on heart's autonomic nervous system, compared to Right interscalene block. This effect is evident on the occurrence of bradycardia and hypotension during shoulder surgery in the beach chair position

Official Title
-----------------
The Effect of the Side of Interscalene Block on the Occurrence of Bradycardia and Hypotension During Shoulder Surgery in the Beach Chair Position

Conditions
-----------------
Shoulder Surgery, Beach Chair Position, Interscalene Block, Hypotension, Bradycardia, Autonomic Nervous System

Intervention / Treatment
-----------------
* Other: Left interscalene block
* Other: Right interscalene block


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: elective shoulder surgery Age 50- 80 years old ASA II - IV Exclusion Criteria: Coagulopathy disorders Infection at the puncture site for the interscalene block Neurological deficit on the side to be operated Allergy to local anesthetics Psychiatric disorders Patient's refusal Problems with patient communication Failure of the interscalene block

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Left interscalene block<br>Left interscalene block on hypotension and bradycardia during beach chair positioning | Other: Left interscalene block<br> <br> |
| Right interscalene block<br>Right interscalene block on hypotension and bradycardia during beach chair positioning | Other: Right interscalene block<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Interscalene block and beach chair positioning | Effect of interscalene block on hypotension and bradycardia during beach chair positioning | Intraoperatively |
ERAS in Video-assisted Mediastinal Surgery

Study Overview
=================
Brief Summary
-----------------
This is a single center, randomized,single blind study to investigate the effectiveness of enhanced recovery regimen (ERAS) in patients undergoing Video-assisted Mediastinal Surgery. And we also going to compare the effectiveness of ERAS with that of traditional regimen in these patients.

Detailed Description
-----------------
Compare to traditional measures, the ERAS protocal mainly includes:Good preoperative visit, shorten the fast time, minimumal invasive surgery procedures, fewer opioids and early movements after surgery. These items have been successfully used in colon cancer surgery, and we thus plan to investigate the effectiveness of these measures in mediastinal surgery.

Official Title
-----------------
The Clinical Study of ERAS Protocol in Video-assisted Mediastinal Surgery

Conditions
-----------------
Enhanced Recovery After Surgery

Intervention / Treatment
-----------------
* Combination Product: ERAS
* Combination Product: Traditional measures


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients elective mediastinal surgery; BMI 18-30 kg/m2. Exclusion Criteria: Patient refuse; ASA≥3; Patients allergic to used anesthetics (propofol,rocuronium), patients with liver and/or kidney and/or mental dysfunction.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: ERAS group<br>The patients in this group receive enhanced measures perioperatively | Combination Product: ERAS<br>* The investigators mainly used enhanced measures perioperatively in mediastinal surgery as these used in other surgery<br>|
| Active Comparator: Traditional group<br>The patients in this group receive traditional measures perioperatively | Combination Product: Traditional measures<br>* The investigators mainly used traditional measures perioperatively in mediastinal surgery as these used in other surgery<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 15-item quality of recovery scale (QoR-15) | This scale mainly reflects the patient's status | At preoperative vist | 
| 15-item quality of recovery scale (QoR-15) | This scale mainly reflects the patient's status | At 24 hours after surgery |
Coxib-inhibition of Duodenal Polyp Growth in FAP

Study Overview
=================
Brief Summary
-----------------
Preliminary data indicate a protective effect on the development of duodenal polyps by coxib treatment. The hypothesis of the present study is that normal therapy doses of rofecoxib for 1 year would stop or reverse the development of premalignant adenomatous lesions in the duodenal mucosa of FAP patients.

Official Title
-----------------
Coxib-inhibition of Duodenal Polyp Growth in Familial Adenomatous Polyposis

Conditions
-----------------
Duodenal Polyposis

Intervention / Treatment
-----------------
* Drug: Rofecoxib
* Drug: placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: FAP patient with previous colectomy and confirmed polyposis Exclusion Criteria: Pregnancy Malignancy NSAID hypersensitivity

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1<br>Rofexocib 25 mg OD, 1 year treatment | Drug: Rofecoxib<br> <br> |
| Placebo Comparator: 2<br>Placebo | Drug: placebo<br>* placebo pills<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Predictive Biomarkers for IGF1R Targeted Therapy in Ovarian Cancer: a Retrospective Study

Study Overview
=================
Brief Summary
-----------------
The main goal of this study is to employ a novel proteomic approach to identify predictive tumor biomarkers that will increase the efficacy of insulin-like growth factor (IGF1R) targeted therapy in epithelial ovarian cancer. It is expected that these predictive biomarkers will be applied to increase the response rate in selected groups of patients.

Conditions
-----------------
Ovarian Cancer

Intervention / Treatment
-----------------
* Other: Immunohistochemistry staining method


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: women who underwent surgery for ovarian cancer Exclusion Criteria: None

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Tissue samples<br>Tissue samples taken from women treated for ovarian cancer will be stained. | Other: Immunohistochemistry staining method<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Responsive to IGF1R therapy | Mean tumor volume will be calculated and growth inhibition will be reported as the percentage decrease of tumor volume compared with the control. | One year |
Prevalence of Sleep Apnea in Patients Presenting for Hip or Knee Replacement Surgery

Study Overview
=================
Brief Summary
-----------------
The study hypothesis is that the prevalence of obstructive sleep apnea in patients presenting for total knee or total hip arthroplasty is higher than generally suspected. The study will include just one arm and results will be compared to a literature control group. Participants referred for preoperative evaluation will be screened using a standard questionnaire. Those at high risk of obstructive sleep apnea will then undergo a formal overnight sleep study (polysomnography).

Detailed Description
-----------------
The study hypothesis is that the prevalence of obstructive sleep apnea in patients presenting for total knee or total hip arthroplasty is higher than generally suspected. The study will include just one arm and results will be compared to a literature control group, a study performed by Harrison et al. and published in the December 2003 issue of The Journal of Arthroplasty. Participants referred for preoperative evaluation will be screened using a standard questionnaire. Those at high risk of obstructive sleep apnea will then undergo a formal overnight sleep study (polysomnography). The Berlin questionnaire is being used for screening.

Official Title
-----------------
Prevalence of Sleep Apnea in Patients Presenting for Hip or Knee Replacement Surgery

Conditions
-----------------
Sleep Apnea, Obstructive

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years old and older Planned total hip or total knee arthroplasty Referral to the internal medicine preoperative evaluation clinic Exclusion Criteria: • None

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Berlin<br>Patients diagnosed with obstructive sleep apnea by polysomnography after being screened with the Berlin questionnaire. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Obstructive Sleep Apnea | The number patients with obstructive sleep apnea whether newly diagnosed or known at study entry. | 9 Months |
Pilot Study of Continuing Aspirin Versus Switching to Clopidogrel After Stroke or Transient Ischemic Attack

Study Overview
=================
Brief Summary
-----------------
Pilot study of continuing aspirin versus switching to clopidogrel after stroke or transient ischemic attack.

Detailed Description
-----------------
Pilot study of continuing aspirin versus switching to clopidogrel after stroke or transient ischemic attack.

Official Title
-----------------
Pilot Study of Continuing Aspirin Versus Switching to Clopidogrel After Stroke or Transient Ischemic Attack

Conditions
-----------------
Transient Ischemic Attack, Stroke, Aspirin, Clopidogrel

Intervention / Treatment
-----------------
* Drug: aspirin versus clopidogrel


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 18 and older. Stroke or transient ischemic attack (TIA) while taking aspirin within one week of consent. Women of child-bearing potential will be included only if there is a negative pregnancy test and they agree to birth control during the treatment period. Exclusion Criteria: Any medical indication for a specific antiplatelet agent (aspirin, clopidogrel, ticlopidine, aggrenox), or an indication for a combination of antiplatelet agents. Any medical indication for anticoagulation, except subcutaneous heparin for deep vein thrombosis prophylaxis. Allergy to aspirin or clopidogrel.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: aspirin versus clopidogrel|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mRS at three months. |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of stroke at three months, bleeding events. |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Transient ischemic attack, Stroke, Aspirin, Clopidogrel