Cognition and Emotion in the SII and IBD

Study Overview
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Brief Summary
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The study aims at showing that the susceptibility in the stress is more raised at the person affected digestive pathologies (SII or IBD) in forgiveness than healthy subjects.

Detailed Description
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The objective of the study which we wish to lead consists in looking for, at the patients SII and IBD in forgiveness, the existence of a correlation between the rate of cortisol(Hormone of the stress) and the level of HRV (Heart Rate Variability) to estimate the inhibitive fronto-amygdalien tonus. So we make the hypothesis that the persons affected by digestive pathologies of type SII or IBD would present an emotional and physiological vulnerability more important than unhurt subjects of pathologies.

Official Title
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Etude de la réactivité émotionnelle Des Patients MICI ou SII

Conditions
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Irritable Bowel Syndrome, Inflammatory Bowel Disease (IBD), Crohn's Disease(CD), Ulcerative Colitis

Intervention / Treatment
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* Behavioral: emotion


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with SII :Membership to the Social Security,SII defined according to the criteria Rome III. Patients with IBD :Membership to the Social Security,patients with a ulcerative colitis(UC) or a Crohn's disease (CD)ileal and/or colic. Exclusion Criteria: Existence of a severe affectation on the general plan (cardiac,respiratory,hematological,renal,hepatic,cancerous), Subject diabetic, Pregnant or breast-feeding woman, Subject included in another clinical and\or therapeutic trial or having been included in a clinical and\or therapeutic trial for less than a month, Subject presenting a psychiatric pathology evident, Person under guardianship.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Control group<br>30 Asymptomatic Healthy Volunteers Intervention : Observation of emotional behavior in asymptomatic healthy volunteers subjected to stress. | Behavioral: emotion<br>* Show that the susceptibility in the stress (recording of Heart Rate Variability;viewing films;...) is more important at the person affected by digestive pathologies (SII or IBD) in forgiveness than to unhurt subjects of pathologies.<br>* Other names: STRESS;|
| Experimental: Experimental group<br>Persons reached by digestive pathologies (SII or IBD). Group SII : 30 patients Group IBD: 60 patients (30 patients RCH and 30 patients CD) Intervention : Observation of emotional behavior in person affected by digestive pathologies subjected to stress. | Behavioral: emotion<br>* Show that the susceptibility in the stress (recording of Heart Rate Variability;viewing films;...) is more important at the person affected by digestive pathologies (SII or IBD) in forgiveness than to unhurt subjects of pathologies.<br>* Other names: STRESS;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| RATE PLASMATIQUE OF CORTISOL COUPLED WITH THE CARDIAC VARIABILITY |  | 24 MONTHS | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| SCORES OF DEPRESSIVE SYMPTOMATOLOGIE AND ANXIETY, RATE PLASMATIQUES OF CATECHOLAMINES, LEPTINE, ADIPONECTINE AND PRO-INFLAMMATORY CYTOKINES. |  | 24 MONTHS | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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HRV, emotion, cognition, stress, cortisol, Autonomic nervous system