Prevalence of Endolymphatic Hydrops With a Hitory of Congenital Cytomegalovirus Infection

Study Overview
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Brief Summary
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The management of patients with a history of congenital CMV infection (whether symptomatic or asymptomatic at birth) is modeled on their usual management.

Detailed Description
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The management of patients with a history of congenital CMV infection (whether symptomatic or asymptomatic at birth) is modeled on their usual management. Patients benefit as part of the care: A clinical cochleo-vestibular examination Functional otoneurological explorations: audiogram, caloric tests, vHIT, otolithic evoked potentials From an uninjected brain MRI Participation in this research entails the addition of an MRI sequence and an injection of contrast product (Gadovist®): - 3D FLAIR MRI sequence dedicated to the exploration of the inner ear, lasting 6min30s, performed 4 hours after the initial injection of contrast product.

Official Title
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Prevalence of Endolymphatic Hydrops in Patients With a History of Congenital Cytomegalovirus Infection With Symptomatic Cochleo-vestibular Involvement

Conditions
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Endolymphatic Hydrops

Intervention / Treatment
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* Device: sequence MRI 3D FLAIR


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient over 6 months old With a history of confirmed congenital CMV infection Suffering from symptomatic cochleo-vestibular dysfunction (average hearing threshold> 20dB in at least one ear and / or abnormal functioning of one or more sectors at the vestibular level) For adult patients, having received informed information about the study and having signed a consent to participate in the study For minor patients written consent of the two holders of the exercise of parental authority Affiliate or beneficiary of a social security scheme Exclusion Criteria: Patient benefiting from a legal protection measure Pregnant or breastfeeding woman Contraindication to MRI (implanted electrical device, metallic foreign body, claustrophobia) Patient with a proven allergy to gadolinium Injection of gadolinium in the previous 7 days Known impairment of renal function ((estimated GFR <60 mL / min / 1.73 m²)

Ages Eligible for Study
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Minimum Age: 6 Months

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: sequence MRI 3D FLAIR|Participation in this research entails the addition of an MRI sequence and an injection of contrast product (Gadovist®): - 3D FLAIR MRI sequence dedicated to the exploration of the inner ear, lasting 6min30s, performed 4 hours after the initial injection of contrast product|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the prevalence of at least one endolymphatic hydrops in patients with a history of congenital CMV infection with symptomatic cochleovestibular dysfunction | Endolymphatic hydrops visualized with 3D FLAIR sequence in MRI | 4 hours after the initial injection of gadolinium, at least for one of the two ears | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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CMV