Serum Lipid Levels and Lp-PLA2 in Chronic Periodontitis

Study Overview
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Brief Summary
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To assess the association between periodontal parameters, serum lipid profile and Lp-PLA2 level in systemically healthy Chronic Periodontitis subjects and healthy controls.

Detailed Description
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Seventy five participants were divided into 3 groups. The groups consisted of GROUP I- generalized severe chronic periodontitis, GROUP II- generalized moderate chronic periodontitis and GROUP III- systemically and periodontally healthy volunteers who served as control. The selected patients were then evaluated for periodontal parameters, lipid profile and Lp-PLA2.

Official Title
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The Association Between Periodontal Status, Serum Lipid Levels and Lipoprotein Associated Lipophosphase A2(Lp-PLA2) in Chronic Periodontitis Subjects and Healthy Controls: A Case Control Study

Conditions
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Chronic Periodontitis (Disorder)

Intervention / Treatment
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* Diagnostic Test: serum lipid levels and Lp-PLA2


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Group I: Subjects with age ≥ 35 years. Presence of at least 24 teeth, with Clinical attachment loss (CAL) ≥ 5mm in more than 30% of sites. Group II: Subjects with age ≥ 35 years. Presence of at least 24 teeth, with Clinical attachment loss (CAL) between 3-4 mm in more than 30% of sites. Group III: Subjects with age ≥ 35 years. Healthy and intact periodontium Exclusion Criteria: Presence of any systemic disease or conditions that could affect periodontal tissues. History of periodontal treatment in past 6 months. Smoking and alcoholism Anomalies of blood and immune system Systemic medication or antibiotic treatment for the previous 6 months. Pregnant females.

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 64 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| GROUP I<br>Estimation of serum lipid levels and Lp-PLA2 in generalized severe chronic periodontitis | Diagnostic Test: serum lipid levels and Lp-PLA2<br>* Estimation of Total Cholesterol, triglyceride, High density lipoprotein, Low density lipoprotein, very low density lipoprotein and Lipoprotein associated lipophosphase A2 in chronic periodontitis<br>* Other names: Biological marker;|
| GROUP II<br>Estimation of serum lipid levels and Lp-PLA2 in generalized moderate chronic periodontitis | Diagnostic Test: serum lipid levels and Lp-PLA2<br>* Estimation of Total Cholesterol, triglyceride, High density lipoprotein, Low density lipoprotein, very low density lipoprotein and Lipoprotein associated lipophosphase A2 in chronic periodontitis<br>* Other names: Biological marker;|
| GROUP III<br>Estimation of serum lipid levels and Lp-PLA2 in systemically and periodontally healthy controls | Diagnostic Test: serum lipid levels and Lp-PLA2<br>* Estimation of Total Cholesterol, triglyceride, High density lipoprotein, Low density lipoprotein, very low density lipoprotein and Lipoprotein associated lipophosphase A2 in chronic periodontitis<br>* Other names: Biological marker;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Estimation of serum Lp-PLA2 | Serum Lp-PLA2 was estimated in all the groups using ELISA | 9 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Estimation of serum lipid profile | Serum Total cholesterol, triglyceride, High density lipoprotein, Low density lipoprotein and very low density lipoprotein | 9 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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chronic periodontitis, lipids, Lp-PLA2