Application of Virtual Mandibular Position in Temporomandibular Jont Reconstruction With Costochondral Graft in Children Jaw Deformity

Study Overview
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Brief Summary
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Hypothesis：Computer-aided design virtual mandibular position is feasible for costochondral graft growing and occlusion stabilizing in the one-stage treatment of children temporomandibular joint ankylosis (TMJA) or condyle absence with jaw deformity. Methods: The inclusion criteria is children patients younger than 12 years old with unilateral TMJA or condyle absence. A virtual mandibular position is designed preoperatively according to the CT data of jaw and dentition. 3D printed templates and occlusal splints are used to guide the costochondral graft and mandibular position. During surgery, the affected ramus is reconstructed with costochondral grafting under the virtual mandibular position. After surgery, the occlusal splint is fixed to maxilla at least one month, and then, replaced by orthodontic functional appliance to promote downward growth of the maxilla. Occlusion, facial symmetry, costochondral graft growing would be evaluated and analysed until adulthood.

Official Title
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Application of Virtual Mandibular Position in Temporomandibular Jont Reconstruction With Costochondral Graft in Children Jaw Deformity.

Conditions
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Temporomandibular Joint Ankylosis, Facial Asymmetry

Intervention / Treatment
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* Procedure: temporomandibular jont reconstruction with costochondral transplantation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: <12 years old Unilateral temporomandibular joint ankylosis or condyle absence； Temporomandibular joint reconstructed with costochondral graft； Exclusion Criteria: Bilateral temporomandibular joint ankylosis or condyle absence Combined with systematic disease

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Children TMJA or condyle absence with Jaw Deformity<br>inclusion criteria: <12 years old; Unilateral temporomandibular joint ankylosis or condyle absence； Temporomandibular joint reconstructed with costochondral graft； | Procedure: temporomandibular jont reconstruction with costochondral transplantation<br>* temporomandibular jont reconstruction with costochondral transplantation guided by virtual mandibular position<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bilateral ramus height,chin deviation,maxilla height | Bilateral ramus height,chin deviation,maxilla height in millimeter. These measurements were accomplished by ProPlan 2.0( SynthesProPlan，Materialise，Belgium） | preoperation | 
| Bilateral ramus height,chin deviation,maxilla height 6 months after operation | Bilateral ramus height,chin deviation,maxilla height in millimeter 6 months after operation. These measurements were accomplished by ProPlan 2.0( SynthesProPlan，Materialise，Belgium） | 6 months after operation | 
| Bilateral ramus height,chin deviation,maxilla height 12 months after operation. | Bilateral ramus height,chin deviation,maxilla height in millimeter 12 months after operation.These measurements were accomplished by ProPlan 2.0( SynthesProPlan，Materialise，Belgium） | 12 months after operation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Virtual mandibular position; temporomandibular joint reconstruction; Jaw deformity;Costochondral graft