Melphalan and Busulfan Followed By Donor Peripheral Stem Cell Transplant, Tacrolimus, and Methotrexate in Treating Patients With Multiple Myeloma

Study Overview
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Brief Summary
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RATIONALE: Giving chemotherapy, such as melphalan and busulfan, before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells. It also helps stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. Giving tacrolimus and methotrexate before or after transplant may stop this from happening. PURPOSE: This phase II trial is studying how well giving melphalan together with busulfan followed by donor peripheral stem cell transplant, tacrolimus, and methotrexate works in treating patients with multiple myeloma.

Detailed Description
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OBJECTIVES: Primary Evaluate transplant-related mortality in patients with multiple myeloma treated with a myeloablative conditioning regimen comprising melphalan and busulfan followed by HLA-matched, allogeneic peripheral blood stem cell transplantation (PBSCT) and graft-vs-host disease prophylaxis with tacrolimus and methotrexate. Secondary Determine the disease response in patients treated with this regimen. Determine the 1-year progression-free survival and overall survival in patients treated with this regimen. OUTLINE: Conditioning regimen: Patients receive melphalan IV over 30 minutes on day -6 and busulfan IV over 3 hours on days -5 to -3. Peripheral blood stem cell transplantation (PBSCT): Patients undergo HLA-matched, related donor, allogeneic PBSCT on day 0. Graft-versus-host disease (GVHD) prophylaxis: Patients receive tacrolimus IV continuously or orally twice daily beginning on day -2 and continuing until day 80 followed by a taper until day 180 in the absence of GVHD or disease progression. Patients also receive methotrexate IV on days 1, 3, 6, and 11. After completion of study treatment, patients are followed every 6 months for 2 years and then annually thereafter. PROJECTED ACCRUAL: A total of 20 patients will be accrued for this study.

Official Title
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A Phase II Study of Intravenous Melphalan and Busulfan Followed by HLA-Matched, Allogeneic Peripheral Blood Stem Cell Transplant for the Treatment of Multiple Myeloma

Conditions
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Multiple Myeloma and Plasma Cell Neoplasm

Intervention / Treatment
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* Drug: busulfan
* Drug: melphalan
* Drug: methotrexate
* Drug: tacrolimus
* Procedure: allogeneic hematopoietic stem cell transplantation
* Procedure: peripheral blood stem cell transplantation


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Diagnosis of multiple myeloma Stage I disease with disease progression during the second of ≥ 2 lines of prior therapy Stage II or III disease, meeting 1 of the following criteria: Failed to achieve at least a partial response after ≥ 2 courses of prior therapy Progressive disease after ≥ 2 courses of prior therapy Presented with high-risk features at diagnosis, including any of the following: Cytogenetic abnormality Del 13 or 4,14 by fluorescent in situ hybridization (FISH) Elevated lactic dehydrogenase Beta 2 microglobulin > 5.5 Circulating peripheral blood plasma cells Any stage disease with disease progression > 6 months after prior autologous stem cell transplantation Availability of an HLA-matched, related donor between 12 and 75 years of age* No bone marrow donors NOTE: *Donors > 75 years of age are eligible at the discretion of the principal investigator PATIENT CHARACTERISTICS: Karnofsky performance status 70-100% Creatinine clearance > 60 mL/min Bilirubin ≤ 2.5 mg/dL ALT/AST < 2 times upper limit of normal Cardiac ejection fraction ≥ 49% DLCO ≥ 50% corrected FEV_1 ≥ 60% Not pregnant or nursing Fertile patients must use effective contraception HIV negative No cirrhosis No chronic inflammatory or fibrotic liver disease PRIOR CONCURRENT THERAPY: See Disease Characteristics At least 6 months since prior autologous transplantation

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: busulfan|nan|
|Drug: melphalan|nan|
|Drug: methotrexate|nan|
|Drug: tacrolimus|nan|
|Procedure: allogeneic hematopoietic stem cell transplantation|nan|
|Procedure: peripheral blood stem cell transplantation|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Transplant-related mortality at 180 days |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disease response (complete response) |  |  | 
| Progression-free survival |  |  | 
| Overall survival at 1 year |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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stage I multiple myeloma, stage II multiple myeloma, stage III multiple myeloma, refractory multiple myeloma