Comparison of Physical Activity Regimens as Treatments for Obstructive Sleep Apnea

Study Overview
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Brief Summary
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The purpose of this study is to compare the efficacy of two different physical activity regimens as complementary or alternative treatment options for the treatment of obstructive sleep apnea. A secondary purpose of the study is to examine the effects of these activity regimens on various health consequences of obstructive sleep apnea, including blood pressure, systemic inflammation, and daytime functioning.

Official Title
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Exercise: A Novel Treatment for Obstructive Sleep Apnea

Conditions
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Obstructive Sleep Apnea

Intervention / Treatment
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* Behavioral: moderate-intensity aerobic and resistance training
* Behavioral: low-intensity stretching


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: moderate-intensity obstructive sleep apnea (AHI >= 15) sedentary status Exclusion Criteria: current treatment for obstructive sleep apnea (CPAP, oral devices, etc.) significant cardiovascular, pulmonary, or metabolic disease uncontrolled hypertension inability to exercise (e.g., musculoskeletal, neuromuscular, orthopedic problems)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: moderate-intensity exercise training<br> | Behavioral: moderate-intensity aerobic and resistance training<br>* Individuals will complete four days of aerobic exercise of moderate intensity (60% of maximal VO2, approximated from heart rate). Duration of aerobic activity will gradually increase from weeks 1 through 4 until 180 min of aerobic exercise at the prescribed intensity is performed each week. Following aerobic exercise on two days per week, moderate-intensity resistance training will be performed using eight different resistance machines. One set of 8-12 repetitions will be performed during weeks 1-4; from week 5-on, 2 sets of 8-12 repetitions will be performed.<br>|
| Active Comparator: low-intensity stretching<br> | Behavioral: low-intensity stretching<br>* Individuals will perform supervised whole-body flexibility exercises on two days per week. Two sets of each exercise will be performed, with the duration of each stretch gradually increasing from 15 sec to 30 sec. A total of 15-20 stretches, focusing on whole-body flexibility, will be performed.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Laboratory polysomnographic assessment of apnea-hypopnea index |  | pre- and post-intervention (12 weeks later) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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obstructive sleep apnea, exercise training, aerobic exercise, resistance exercise