Application of Celiac Plexus Block in Postoperative Analgesia of Upper Abdominal Surgery

Study Overview
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Brief Summary
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This subject intends to explore the value of intraoperative celiac plexus block in postoperative acute pain management and its promoting effect on patients' rapid recovery during epigastric laparotomy through a randomized controlled trial.

Detailed Description
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This study is a single center, randomized, double-blind controlled study. After calculating the sample size, 66 subjects would be randomly assigned to nerve block group (NB group: local anesthetic injection at the target position) and blank control group (GC group: no celiac plexus block) according to the ratio of 1:1, in order to evaluate the effectiveness and safety of celiac plexus block (CPB) as a part of multimodal analgesia for postoperative pain management. Anesthesia protocol: the standard anesthesia protocol for open upper abdominal surgery in our hospital was adopted. Postoperative analgesia plan: before abdominal closure at the end of operation, The surgeon was instructed to perform a single celiac plexus block (CPB) under direct vision. Ropivacaine was injected into the target nerve in NB group, but no injection in GC group. After the operation, the anesthesiologist used ropivacaine to perform ultrasound-guided lower costal oblique transverse abdominal muscle plane nerve block (tapb) and rectus abdominis posterior sheath nerve block. When leaving the operating room, connect intravenous analgesia pump. Patients with subjective pain score of 3 or above can press. If the analgesia is insufficient, intravenous injection of dezocine can be added temporarily. The intravenous analgesia pump shall be withdrawn after 72 hours of use. If the analgesia pump is used up and is still needed, the anesthesiologist can evaluate and add medicine.

Official Title
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Application of Celiac Plexus Block in Postoperative Analgesia of Upper Abdominal Surgery

Conditions
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Pain, Postoperative, Nerve Block

Intervention / Treatment
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* Procedure: Celiac plexus block
* Drug: Ropivacaine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients will accept open upper abdominal surgery and requiring intestinal anastomosis. Exclusion Criteria: Patients cannot cooperate with pain assessment; Patients with analgesic drug abuse; Patients with other operations in the same period; ④ Patients need to be cared in ICU after operation; ⑤ Allergic to amide local anesthetics. ⑥ Preoperative abdominal CT shows obvious anatomical variation of celiac ganglion; ⑦ Combined with abdominal aortic disease such as aneurysms.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: NB group<br>Celiac plexus block (CPB) was added to the postoperative analgesia plan. CPB: the target nerve is located in the retroperitoneal space, embedded in the fat in front of the aorta, and distributed in a network along the anterolateral wall of the aorta, just at the beginning of the celiac trunk. During direct vision (anterior) block, first expose the upper edge of the pancreas, palpate the abdominal aorta and abdominal trunk, and palpate the pulsation of the common hepatic artery and splenic artery at the level of the abdominal trunk. Use a 25g 6cm puncture needle with an extension tube and a syringe pumped back by an assistant to form a negative pressure, then the needle is inserted into the fat on both sides of the abdominal aorta. If there is no blood or fluid outflow, slowly inject 10ml of 0.5% ropivacaine each side. After pulling out the needle, observe whether there is damage and bleeding. If necessary, use low-energy electrocoagulation to stop bleeding. | Procedure: Celiac plexus block<br>* The surgeon is instructed to perform a single celiac plexus block under direct vision. 10ml 0.5% ropivacaine is injected into the nerve in both sides.<br>Drug: Ropivacaine<br>* Mixed solution for nerve block, made of 0.75% ropivacaine (Naropin, Astrazeneca AB) diluted in different proportions.<br>|
| No Intervention: GC group<br>The same analgesic plan as the experimental group, except that CPB is not performed. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Opioid consumption | Morphine equivalent | 72 hours after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to first flatus |  | 72 hours after surgery | 
| Pain scores | VAS (0 indicates no pain and score 10 indicates the most severe pain) | 6, 12, 24, 48, 72 hours after surgery | 
| Blood pressure | Mean arterial pressure | Baseline and 5、10、20 minutes after CPB | 
| Heart rate |  | Baseline and 5、10、20 minutes after CPB | 
| Cardiac index |  | Baseline and 5、10、20 minutes after CPB | 
| Systemic vascular resistance index |  | Baseline and 5、10、20 minutes after CPB | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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celiac plexus block