Prospective Study for Neuromelanin Image Analysis

Study Overview
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Brief Summary
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In order to develop an image analysis system that automatically detects and quantifies neuromelanin, this study aims to construct a database of a wide sample by collecting brain MRI neuromelanin images prospectively.

Official Title
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Prospective Data Collect Study for Development of Neurimelanin Image Analysis System

Conditions
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Parkinson Disease

Intervention / Treatment
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* Device: MRI Imaging


Participation Criteria
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Eligibility Criteria
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Parkinsin group Inclusion Criteria: Adults over 19 years old Those who have clinically shown Parkinson's symptoms such as tremor, Rigidity, Bradykinesa and gait disturbance and are scheduled to take MRI scans Dopamine transporter imaging shows a significant decrease in visual dopamine intake A person who can read and understand the description and informed consent form Upon hearing and fully understanding the detailed explanation of this clinical trial, a person who has voluntarily decided to participate and agreed in writing to comply with the precautions Exclusion Criteria: Patient with a history of claustrophobia and mental illness; Patient with metallic substances in the body Any female subject who is likely to be pregnant who does not agree to contraception in a medically permitted manner during this clinical trial period Pregnant or lactating women Other cases where the investigator judged that it is difficult to participate in the study; Healthy volunteer group Inclusion Criteria: Adults over 19 years old A person who has no family history or diagnostic history of movement disorders; A person with a score of 8 or higher on the CCSIT(cross cultural smell identification test) A person with a score of 27 or higher on the MMSE Test No Parkinson's symptoms on a neurological examination Upon hearing and fully understanding the detailed explanation of this clinical trial, a person who has voluntarily decided to participate and agreed in writing to comply with the precautions Exclusion Criteria: Patient with a history of central nervous system disease or cognitive disorder Patient with a history of claustrophobia and mental illness; Patient with metallic substances in the body Any female subject who is likely to be pregnant who does not agree to contraception in a medically permitted manner during this clinical trial period Pregnant or lactating women Other cases where the investigator judged that it is difficult to participate in the study;

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patient group<br>Patient with parkinson disease | Device: MRI Imaging<br>* Neuromelanin sequence imaging<br>|
| Experimental: Healthy volunteer group<br>Healthy volunteer | Device: MRI Imaging<br>* Neuromelanin sequence imaging<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differences in Neuromelanin Volume by Age | Descriptive Statistics for Neuromelanin Volume Measured by MRI Image by Age | Within 1 weeks after enrollment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differences in Neuromelanin Volume by group | Descriptive Statistics for Neuromelanin Volume Measured by MRI Image by group | Within 1 weeks after enrollment |