The Sensitivity and Specificity of Sniff Dog as a Tool in Diagnosing the Suspected Tumor Patients

Study Overview
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Brief Summary
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Previous studies have demonstrated that sniff dogs can identify cancer patients from healthy subjects through sniffing exhaled breath air or blood or serum or urine or feces. It is hypothesized that sniff dogs may be used as a tool in identifying cancer patients in the high risk population or suspected patients. Trained dogs will sniff serum from participants who are suspected to suffer from tumor by their physicians and not yet but will be diagnosed by pathological examination.The results will be compared with the outcome of the pathological examination.

Official Title
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The Sensitivity and Specificity of Sniff Dog as a Tool in Diagnosing the Suspected Tumor Patients

Conditions
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Neoplasia

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy volunteers who have been examined by the currently used procedures and find to be without tumors. Patients in the breast surgery, thoracic surgery, gynecological and neurosurgery departments with lesions with characteristics of tumors Exclusion Criteria: Patients who have had pathological results

Ages Eligible for Study
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Minimum Age: 1 Year

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy volunteers<br>Healthy volunteers measured by currently used healthy screening procedures | |
| Suspected breast cancer subjects<br>Suspected breast cancer subjects without pathological examination yet but will have it soon | |
| Suspected lung cancer subjects<br>Suspected lung cancer subjects without pathological examination yet but will have it soon | |
| Suspected neurological tumor subjects<br>Suspected neurological tumor subjects without pathological examination yet but will have it soon | |
| Suspected patients with gynecological tumor<br>Suspected subjects with gynecological tumors without pathological examination yet but will have it soon | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| sensitivity and specificity of the sniff dogs as a tool in diagnosing tumors | The results that obtained from the dogs will be compared with these of the pathological examinations. Sensitivity = the No. of patients identified by the dogs as cancers / the No. of patients suffering from cancer confirmed by pathological examination. Specificity = No. of subjects signaled by the dog as non-cancers / No. of subjects confirmed by pathological examination as non-cancer subjects. | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| behavior patterns of the sniff dogs to different diseases | The behavior (lying before the tank for positive, neglecting the tanks) of the dog will be recorded and compared with the results of the pathological examination. | 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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tumor, cancer