Influence of Compound Qingre Granule on the Inflammatory Markers in Patient of FUO With Excess-heat Syndrome

Study Overview
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Brief Summary
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The purpose of this study is to observe inflammatory markers like TNF (tumor necrosis factor), IL-1 (interleukin-1), IL-6 (interleukin-6),TREM-1 (triggering receptor expressed on myeloid cells-1), etc, in patient of FUO with excess-heat syndrome and the influence of Compound Qingre Granule on the inflammatory markers.

Detailed Description
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All the cases will be provided by the Infectious Diseases Department of Beijing Friendship Hospital.Each patient should sign informed consent. Assessing the accuracy, completeness, or representativeness of registry data by comparing the data to medical records. After collecting, sorting and entering the data, reducing the missing value, and then checking into the database. The stochastic indicator method will be used to simple random sampling, to ensure the probabilities of each individuals be given Chinese medicine intervention are equal.Operations must be standard to reduce errors. Quality assurance plan: Patient of fever within two weeks, or whose temperature is below 38.5 degree centigrade will be excluded. The registration form includes the following parts: Name, sex, age, address, phone number, admission time, primary diagnoses and levels of Inflammatory markers. Data will be analyzed using the SPSS17.0 (Statistical Product and Service Solutions 17.0) statistical software. Difference of measurement data will be compared with analysis of variance,and difference of enumeration data will be compared with rank-sum test.P<0.05 has statistical significance.

Official Title
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Inflammatory Markers in Patient of FUO With Excess-heat Syndrome and the Influence of Compound Qingre Granule on the Inflammatory Markers

Conditions
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Fever of Unknown Origin

Intervention / Treatment
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* Drug: Compound Qingre Granule


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient of fever of unknown origin (FUO). Exclusion Criteria: Patient of fever within two weeks, or whose temperature is below 38.5 degree centigrade.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control group<br>Conventional treatment methods will be given to cases in control group. | |
| Experiment group<br>On the base of control group, Compound Qingre Granule will be added to in experiment group. | Drug: Compound Qingre Granule<br>* A kind of Chinese patent medicine, which is developed by Dr.Shuwen Zhang and Dr.Baoen Wang from Beijing Friendship Hospital.<br>* Other names: Fufang Qingre Keli;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Inflammatory marker (TREM-1) in patient of FUO |  | 7th day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Inflammatory marker (TNF) in patient of FUO |  | 7th day | 
| Inflammatory marker (IL-1) in patient of FUO |  | 7th day | 
| Inflammatory marker (IL-6) in patient of FUO |  | 7th day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Inflammatory markers