linjc16/ctgov huggingface dataset:
Alzheimer Prevention Trials (APT) Webstudy

Study Overview
=================
Brief Summary
-----------------
The goal of the Alzheimer Prevention Trials (APT) Webstudy is to accelerate enrollment for Alzheimer's disease (AD) clinical trials by identifying and tracking individuals who may be at higher risk for developing AD dementia.

Detailed Description
-----------------
The APT Webstudy will use web-based cognitive testing and questionnaires to generate a risk score which will be used to identify individuals who may be at an increased risk for developing AD dementia. Individuals who join the APT Webstudy will register at https://www.aptwebstudy.org/, sign an electronic informed consent form (ICF), provide basic demographic information and participate in web-based cognitive testing. Participants will return the APT Webstudy quarterly (every 3 months) to complete the cognitive testing again. Based on the risk score and changes identified in the cognitive testing results, participants will be invited to visit a partnering clinical trial site for an in-person visit with biomarker testing and clinical assessment. The combined results of the web-based assessments, with the biomarker and clinical assessments, will allow an adaptive statistical algorithm to improve the selection of those at highest risk for developing AD. To Join the APT Webstudy, please visit https://www.aptwebstudy.org/.

Official Title
-----------------
Alzheimer Prevention Trials (APT) Webstudy

Conditions
-----------------
Dementia, Alzheimer Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: male or female at least 50 years of age no evidence of dementia willing to participate in remote longitudinal cognitive testing and possible referral for biomarker assessment based on risk Exclusion Criteria: N/A. Anyone can register for the APT Webstudy, however, only individuals identified using the risk algorithm will be referred for in-person biomarker assessments.

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Enrollment into Alzheimer's prevention research studies |  | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Referral into prevention research studies |  | 5 years | 
| Number of individuals enrolled into Alzheimer's prevention studies |  | 5 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Alzheimer's, Prevention, Web-Based
Video Assisted Ablation of Pilonidal Sinus

Study Overview
=================
Brief Summary
-----------------
The investigators supposed that the complete video assisted ablation of pilonidal sinus (VAAPS) could be an effective minimally invasive treatment of pilonidal sinus. This new minimally invasive treatment allows the identification of the sinus cavity with its lateral tracks, the destruction and the removal of all infected tissue and the removing of any hair.

Official Title
-----------------
Video Assisted Ablation of Pilonidal Sinus. Evaluation of Safety and Efficacy of a New Minimally Invasive Technique

Conditions
-----------------
Pilonidal Sinus

Intervention / Treatment
-----------------
* Procedure: Video Assisted Ablation of Pilonidal Sinus


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of chronic pilonidal sinus Exclusion Criteria: Inability to consent to the study Recurrent pilonidal sinus after an outmidline technique

Ages Eligible for Study
-----------------
Minimum Age: 15 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: pilonidal sinuses<br>All consecutive patients with diagnosis of chronic sacrococcygeal pilonidal sinus will be screened for the enrollment in our study. | Procedure: Video Assisted Ablation of Pilonidal Sinus<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Infection | Wound infection was defined as redness and/or oedema of the skin and/or discharge | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recurrence | Recurrence can be divided into two groups: early and late. Early recurrence is usually due to failure to identify one or more sinuses. Late recurrence is usually due to secondary infection caused by residual hair or debris that was not removed at operation, inadequate wound care or insufficient attention to depilation | 1 year |
Effect of Aging on Postural Stability

Study Overview
=================
Brief Summary
-----------------
Postural control of human body is a complex process involving visual , vestibular, somatosensory system and their central processing , add the vestibular system through its multiple connection coordinates movements of the head with movement of the eyes (to maintain clear vision ), trunk , and limbs (to maintain cephalic and postural stability ) via vestibulo-ocular and vestibulo-spinal reflexes respectively Global postural control shows alterations with aging increasing the chance of falls in the population aged 60 years or older, In older adults, poor postural balance can indicate an impaired ability to recover from small postural perturbations and be predictive of future falls

Official Title
-----------------
Effect of Aging on Postural Stability

Conditions
-----------------
Effect of Aging on Postural Stability

Intervention / Treatment
-----------------
* Device: computerized dynamic posturography (sensory orgnization test)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age: from 60 years to 80 years old. Sex: males and females All subject had no audio vestibular disease's. No evidence of cognitive dysfunction. No evidence of musculo-skeletal abnormalities. No motion intolerance. No history of any disease required to give treatment that could affect results Exclusion Criteria: Old age person with cognitive dysfunction. Old age person with musculo-skeletal disorder. Adult person below age 60 years old. Old age person with neurological disease, motion intolerance, visual disorder, diabetes mellitus and hypertension.

Ages Eligible for Study
-----------------
Minimum Age: 60 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: computerized dynamic posturography (sensory orgnization test)|assess of an individual's ability to maintain static and dynamic stance. The assessment is composed of a battery of tests that are similar to everyday conditions of daily living. There are four main components to CDP that are used clinically: the Sensory Organization Test (SOT),|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of change in balance function | Using computerized dynamic posturography ( sensory organization test) | 12 months |
Primary Prevention ICD French Registry

Study Overview
=================
Brief Summary
-----------------
The indication of implantable cardioverter defibrillator (ICD) therapy for primary prevention of sudden cardiac death has been introduced later in France than in other parts of the World. Overall, we aimed to assess the risk-benefit ratio of this strategy over a 10 year period.

Official Title
-----------------
Observatoire Multicentrique Français Des Porteurs de Défibrillateur Automatique Implantable en Prévention Primaire (Cardiopathie Ischémique ou Cardiomyopathie Dilatée)

Conditions
-----------------
Evaluation of Primary Prevention ICD in Real Life

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Coronary artery disease or dilated cardiomyopathy with low ejection fraction implanted with an ICD in the setting of primary prevention (criteria at the discretion of the physician) Exclusion Criteria: Setting of secondary prevention Other cardiopathies such as congenital, channelopathies, valvulopathies
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidences of Appropriate Therapies (ATP and Shocks) and ICD-Related Complications |  | 3-year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cause-of-Death Analysis |  | 3-year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
implantable cardioverter defibrillator, death, shock, mortality, complication, sudden death
Perceived Barriers to Patient Adherence After Pediatric Solid Organ Transplantation

Study Overview
=================
Brief Summary
-----------------
In this study, doctors will observe how and when pediatric patients who have received a solid organ transplant take their prescribed medication, and determining if there are reasons that keep these patients from taking all of their medicine.

Detailed Description
-----------------
Adhering to treatment regimens after solid organ transplantation is critical for the prevention of complications, including acute and chronic organ rejection. It is important to recognize the perceived barriers to following treatment regimens and identify ways to address these barriers early in the course of treatment.

Official Title
-----------------
Perceived Barriers to Patient Adherence After Pediatric Solid Organ Transplantation (CTOTC-05)

Conditions
-----------------
Organ Transplantation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subject and/or guardian must be able to understand and provide informed consent/assent in English or Spanish Male or female primary solid organ transplant patients 0-21 years of age Recipients at least 1 month post-transplant hospital discharge Exclusion Criteria: Inability or unwillingness of a participant or parent/guardian to give informed consent or comply with study protocol Condition or characteristic which in the opinion of the investigator makes the participant unlikely to complete the questionnaires Re-transplant recipient Multi-organ transplant recipient

Ages Eligible for Study
-----------------
Maximum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cross-Sectional Study Group<br>Cross-sectional comparison of perceived barriers to adherence to post-transplant immunosuppressant regimens in parents/legal guardians of children 0-11 years versus adolescents 12-21 years | |
| Longitudinal Study Group<br>Subset of Cross-Sectional Study Group to evaluate whether perceived barriers to adherence increase with time during the first year following transplantation | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Perceived barriers to adherence in adolescents and parent/legal guardian of pediatric patients | Barriers assessed using Brief Medication Questionnaire (BMQ); Adolescent Medication Barrier Scales questionnaire (AMBS); and Parent Medication Barriers Scale questionnaire (PMBS) | 1 month post transplant | 
| Change in perceived barriers to adherence from baseline to follow-up | Barriers assessed using Brief Medication Questionnaire (BMQ); Adolescent Medication Barrier Scales questionnaire (AMBS); and Parent Medication Barriers Scale questionnaire (PMBS) | 12 months post transplant |
Plethysmography Variability Index Monitoring for Parturients With Antepartum Hemorrhage

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the use of continuous noninvasive intraoperative plethesmography variability index in conjunction with Hemoglobin levels monitoring using Masimo Radical-7™ Pulse CO-Oximeter during elective cesarean sections in patients with antepartum and intrapartum hemorrhage as a guide for fluid and blood transfusion practice .

Official Title
-----------------
Continuous Non Invasive Monitoring of Both Plethysmography Variability Index and Total Hemoglobin During Cesarean Section for Antepartum Hemorrhage As a Method For Early Detection of Bleeding

Conditions
-----------------
Antepartum Hemorrhage

Intervention / Treatment
-----------------
* Device: Masimo Radical-7™ Pulse CO-Oximeter


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Anesthesiologist (ASA) Physical status I - II. patients aged from 18 to 40 years full-term multigravida parturients antepartum hemorrhage singleton fetus Exclusion Criteria: Patients with known cardiac problem peripheral circulatory failure of the upper extremities significant liver disease significant renal disease significant coagulopathy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Masimo Radical-7™ Pulse CO-Oximeter|a device collecting data regarding PVI, PI & spHB|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pleth Variability Index |  | 8 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hemoglobin level |  | 8 months |
Hypochlorous Acid Disinfection Prior to Cataract Surgery

Study Overview
=================
Brief Summary
-----------------
Antibiotics are commonly utilized to reduce the bacterial population of the eye prior to surgery with the assumption that this reduces the risk of endophthalmitis, although it is not clear if this actually occurs. This study will investigate the use of Hypochlorous Acid, a commercially available over the counter (OTC) medication to see if this will reduce the bacterial population prior the cataract surgery.

Official Title
-----------------
Effect of Hypochlorous Acid Disinfection on Ocular Flora Prior to Cataract Surgery

Conditions
-----------------
Cataract, Endophthalmitis

Intervention / Treatment
-----------------
* Drug: Hypochlorous Acid Gel 0.02%


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Patients undergoing cataract surgery. Exclusion Criteria: Age <18 years old Vulnerable subjects Non-English Speakers

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 95 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Hypochlorous Gel Application<br> | Drug: Hypochlorous Acid Gel 0.02%<br>* 0.02% Hypochlorous Acid Gel (OCusoft Hypochlor GEL) will be sprayed onto the closed eyelid of the surgical eye while covering the fellow eye with palm of the hand, left for 60 seconds, then wiped off with a clean gauze, tissue, or cotton ball.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reduction in bacterial flora in eyelashes of treatment eye compared to fellow eye | Swab will be used to obtain samples from the eyelashes bilaterally and cultured | On day of surgery prior to surgical prep | 
| Reduction in bacterial flora in conjunctiva of treatment eye compared to fellow | Swab will be used to obtain samples from the conjunctiva bilaterally and cultured | On day of surgery prior to surgical prep | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Ocular/Eyelid Flora
Validation of a New Algorithm for Screening Sleep Apnea Syndrome From Electrocardiogram

Study Overview
=================
Brief Summary
-----------------
Sleep apnea syndrome is a prevalent disease, recognized as an independant risk factor for cardiovascular diseases The gold standard for the diagnosis of sleep apnea is the polysomnography. But polysomnography is time-consuming and very expensive. We developed an algorithm for screening sleep apnea from electrocardiographic signal. This would lead to the simplification of screening sleep apnea by using a two-channels recording device and computerizing the scoring of respiratory events. The validation of the algorithm will consist in comparing the number of apnea and hypopnea per hour of sleep (AHI) detected by the algorithm from the electrocardiographic signal recorded during a standard polysomnography in the Center for Sleep Medicine and Research in Nancy, with the AHI resulted from the standard interpretation of the same polysomnography by experts in sleep scoring (gold standard).

Official Title
-----------------
Validation of an Innovative Algorithm for Screening Sleep Apnea Syndrome From an Electrocardiographic Recording During Sleep

Conditions
-----------------
Sleep Apnea

Intervention / Treatment
-----------------
* Diagnostic Test: polysomnography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: all patients with a polysomnography recorded in the Center for Sleep Medecine and Research (CSMR) in Nancy from january 2019 and june 2020 results of standard interpretation of polysomnography giving a number of hypopnea and apnea per hour of sleep (AHI) superior to 5 Exclusion Criteria: refusal to participate

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with sleep apnea<br>We selected 150 patients recorded by polysomnography between january 2019 and june 2020 in the Center for Sleep Medecine and Research in Nancy. | Diagnostic Test: polysomnography<br>* Polysomnography consisted in recording sleep parameters during one night, using a non-invasive multi-channels device, including respiratory sensors, electrocardiogram and electroencephalogram<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Concordance of the number of sleep hypopnea and apnea between an algorithm computerizing the electrocardiographic signal and the standard interpretation of the polysomnography by an expert in sleep scoring (gold standard) |  | 18 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
sleep, electrocardiogram, screening, apnea, polysomnography, algorithm
Does Aerobic Training Followed by Resistance Training Enhance Aerobic Capacity in Seniors

Study Overview
=================
Brief Summary
-----------------
In healthy young subjects a single bout of strength training following endurance training has been shown to improve markers for aerobic capacity in muscle compared to a single bout of endurance training alone. The present project tests the hypothesis: 12 weeks of training with sessions of endurance training followed by strength training is superior to endurance training alone for health participants 50-65 years of age. The outcome measures are maximal oxygen uptake and knee-extension strength.

Official Title
-----------------
Does Aerobic Training Followed by Resistance Training Enhance Aerobic Capacity in Seniors? A Randomized Controlled Trial.

Conditions
-----------------
Elderly

Intervention / Treatment
-----------------
* Behavioral: exercise training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy understanding Danish language Exclusion Criteria: medical contraindication for training taking beta-blockers physical exercise training more than 2 hrs per week

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: endurance training<br>40 min bicycle or treadmill training at 60% maximal oxygen uptake | Behavioral: exercise training<br> <br> |
| Experimental: Strength following endurance training<br>20 minutes bicycle or treadmill training at 60% maximal oxygen uptake followed by 20 minutes stength training increasing from 15RM to 10RM | Behavioral: exercise training<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| maximal oxygen uptake |  | 12 weeks | 
| knee extension strength |  | 12 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
endurance training,, strength training,, aerobic capacity,, muscle strenght, physical capacity