Role of Hyaluronic Acid in Bone Healing After Dental Extraction

Study Overview
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Brief Summary
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This is a randomized controlled trial with a split mouth design. Patients with an indication of lower dental extraction will be asked to join this research project at the Department of Oral and Maxillofacial Surgery at University of Damascus Dental School. Each patient whose case requires bilateral extraction, one side will serve as an experimental side, whereas the other side will serve as a control. Participants should have symmetric teeth that need extraction in the lower jaw. Hyaluronic acid will be injected following extraction in one of the two sides with random allocation. cone-beam computerized tomography (CBCT) images will be taken for each participant immediately post-extraction and at six months post-operatively.

Detailed Description
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I- Clinical examination variables: Buccolingual distance and distomesial distance will be measured for each participant at 2 assessment times: directly post-extraction and six months post-extraction. II- Radiographic examination variables: Linear measurements Vertical bone fill Bone mineral density

Official Title
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A Clinical and Experimental Study to Evaluate the Efficacy of Locally Applied Hyaluronic Acid in Bone Healing Following Dental Extraction

Conditions
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Patients With Dental Extraction

Intervention / Treatment
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* Drug: Hyaluronic Acid


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18-60 years old Symmetric teeth requiring extraction in the lower jaw Systematically healthy Exclusion Criteria: Smokers Pregnancy (for female participants) Diabetic patients Patients with metabolic problems

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Hyaluronic Acid Group<br>In this Group, Hyaluronic acid will be injected following extraction. | Drug: Hyaluronic Acid<br>* This material is going to be injected into the extraction socket in order to promote bone healing.<br>|
| No Intervention: Traditional Extraction Group<br>In this group, traditional extraction procedures will be followed. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in bone mineral density (BMD) | BMD is the amount of bone tissue in a certain volume of bone. This variable is going to be measured on CBCT images. | (BMD) will be measured two times in this study: directly at the day of extraction and six months post-extraction. | 
| Vertical bone fill | 'Vertical bone fill' is the distance between the base of the extraction socket and cement-enamel junction directly after extraction and minus the distance between base of the extraction socket and cement-enamel junction six months post-extraction. This variable is going to be measured on CBCT images. | This variable is going to be measured at 6 months post-extraction | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Buccolingual distance | Buccolingual distance is the distance between buccal wall and lingual wall of the extraction socket. This variable is going to be measured clinically. | at six months post-extraction | 
| Mesiodistal distance | Mesiodistal distance is the distance between mesial wall and distal wall of the extraction socket. This variable is going to be measured clinically. | at six months post-extraction |