Alternative Antibiotic Regimen in Periodontitis Treatment

Study Overview
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Brief Summary
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Context and Aims: Several studies have demonstrated an association between obesity, periodontitis, and exercise. This study aimed to investigate the effects of regular exercise on obese women with periodontal disease, using serum, saliva, and gingival crevicular fluid (GCF) samples. Settings and Design: A before-after study design was adopted to evaluate the effects of 12 weeks of regular exercise on obese women grouped according to periodontal status, without a control group (no exercise). Methods and Material: The study sample comprised fifteen patients without periodontitis (NP group) and 10 patients with chronic periodontitis (CP group), from whom periodontal parameters were measured and serum, saliva, and GCF samples were collected. Body mass index (BMI), anthropometric measurements, somatotype-motoric tests, and maximal oxygen consumption (VO2max) were recorded at baseline and after exercise. Statistical analysis used: MedCalc was used for statistical analysis.

Official Title
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Comparison of Ofloxacin and Metronidazole/Amoxicillin on the Treatment of Periodontitis.

Conditions
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Amoxicillin, Metronidazole, Ofloxacin, Periodontitis, Root Planing

Intervention / Treatment
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* Drug: Ofloxacin
* Drug: Amoxicillin
* Drug: Metronidazole


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The periodontal diagnosis of participants with generalized periodontitis stage III-IV/grade C. Systemically healthy participants with generalized periodontitis were enrolled if they were between 18 and 40 years of age, and had no allergies to penicillin, metronidazole or quinolones, a history of antibiotic therapy or periodontal therapy within the preceding six months Exclusion Criteria: Subjects were excluded if they had any known systemic diseases or conditions that can/could influence the periodontal status, allergies to quinolones, penicillin or metronidazole, a history of antibiotic therapy, or periodontal treatment within the preceding six months

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Ofloxacin group<br> | Drug: Ofloxacin<br>* 400 mg, 1 time per day for 5 days<br>|
| Active Comparator: Amoxicillin plus Metronidazole group<br> | Drug: Amoxicillin<br>* 500 mg, 3 times per day for 7 days<br>Drug: Metronidazole<br>* 500 mg, 3 times per day, for 7 days<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Probing depth | Probing depth was recorded at the baseline, first, third, and sixth month. The changes were evaluated among and between groups. | 6-months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical attachment loss | Clinical attachment loss was recorded at the baseline, first, third, and sixth month. The changes were evaluated among and between groups. | 6-months |