Meningitis With Cerebral Vasculitis in Children

Study Overview
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Brief Summary
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Purulent meningitis are life-threatening diseases in childhood. Cerebral vasculitis have been described in bacterial meningitis, but poor is known about their physiology and their impact on outcome. The investigators decide to realize a retrospective mono-centric study carried out at Montpellier university hospital which looks back at a 7-year study(2009-2016). The Investigators selected purulent meningitis cases based on the bacteriological data provided by the HDB (hospital data base). The Investigators divides in two groups : Group A if patients present a cerebral vasculitis ( radiologic diagnostic by RMI or tomodensitometry), in all, cases the diagnosis of vasculitis was confirmed by a radiologist specialised in neuropaediatrics by a second reading;Group B purulent meningitis with a cerebral vasculitis imaging. Tuberculous meningitis, meningitis in CSF shunt, and in patients having chemotherapy were excluded. The investigators report clinical and biological finding, inflammatory marker at the onset. The Investigators register also the clinical evolution and sequelae

Detailed Description
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Meningitis steel are a cause of death in childhood. Cerebral complication are often responsable of poor prognosis. One of these complication vasculitis is steel not weel understood. There are only few study about it on children. It is a retrospective study about 17 cases of chil which bacterial meningitis coupled wiethe cerebral vasculitis, the Investigators will describe epidemiology, bacteriology, evolution and corticosteroid treatment in this patients.

Official Title
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Retrospective Study About 17 Cases of Child With Bacterial Meningitis Coupled With Cerebral Vasculitis

Conditions
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Bacterial Meningitis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: bacterial meningitis with LCR confirmation Exclusion criteria: tuberculous meningitis, immunosuppressor treatment, material like DVP

Ages Eligible for Study
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Minimum Age: 1 Day
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Found a difference demographic data | Found a difference demographic data between population A and B (age) | 1 day | 
| Found a difference demographic data | Found a difference demographic data between population A and B (gender) | 1 day | 
| Found a difference Clinical manifestation | Found a difference Clinical manifestation between population A and B | 1 day | 
| Found a difference Inflammatory parkers | Found a difference Inflammatory parkers between population A and B | 1 day | 
| Found a difference Infectious agent | Found a difference Infectious agent between population A and B | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Found a difference in the evolution of the diseases between group A and B | The data analysed will be : presence of seizure within the next 6 month before the last survey, necessity of antiepileptic treatment, development delay, presence of neurologic deficiency(palsy), persistence of abnormality on neuroimaging. | 1 day | 
| In the A group, studying the relationship between prescription of steroids pulse and final outcome and presence of sequelae. | Sequelae will be defined by the presence of one of this element : : presence of seizure within the next 6 month before the last survey, necessity of antiepileptic treatment, development delay, presence of neurologic deficiency(palsy), persistence of abnormality on neuroimaging. | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cerebral vasculitis