Assessment Of Carotid Flow During General Anesthesia

Study Overview
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Brief Summary
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Proper identification of patients who would benefit from fluid infusion (fluid responsiveness) is one of the most crucial challenges in anaesthesia and critical care. Reliability of several invasive measurements used for this purpose for many years have been questioned recently. The study will evaluate consistency between carotid artery flow derivatives and standard haemodynamic measurement (LIDCO rapid) in navigation of intraoperative fluid therapy.

Official Title
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Assessment of Fluid Responsiveness With Carotid Flow Change During General Anaesthesia

Conditions
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Anesthesia, Fluid Responsiveness

Intervention / Treatment
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* Diagnostic Test: Fluid bolus


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Major abdominal surgery Artery catheter required Exclusion Criteria: Laparoscopic surgery Known history of carotid endarterectomy Known history of carotid stenosis Non-sinus rhythm Systolic or diastolic heart failure Chronic kidney disease Pulmonary hypertension Carotid artery anomaly Unable to visualise carotid artery Angle of correction > 60

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Interventional Model Description: All patients included in the study will receive 4 ml/kg fluid bolus.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Fluid bolus<br>Patients included in the study will receive fluid bolus. | Diagnostic Test: Fluid bolus<br>* All patients included in the study will receive 5 ml/kg fluid bolus of a balanced crystalloid solution.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in cardiac output | A measure of change of scaled cardiac output (nCO) with LiDCO device | Before and 2 minutes after intervention | 
| Change in a corrected carotid artery flow | Ultrasound measure of corrected carotid artery flow time | Before and 2 minutes after intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in pulse pressure variation | A measure of change of pulse pressure variation (PPV) with LiDCO device | Before and 2 minutes after intervention | 
| Change in stroke volume variation | A measure of change of pulse pressure variation with LiDCO device | Before and 2 minutes after intervention | 
| Change in a carotid blood flow | Ultrasound measure of corrected carotid blood flow time | Before and 2 minutes after intervention | 
| Change in a velocity time integral of carotid flow | Ultrasound measure of velocity time integral of carotid flow | Before and 2 minutes after intervention | 
| Change in the maximal systolic carotid velocity variation | Ultrasound measure of the maximal systolic carotid velocity variation | Before and 2 minutes after intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Fluid Responsiveness, Anesthesia, Surgery, Stroke Volume Variation, Fluid status,