QEEG and Qualitative EEG for the Identidification of Abnormal Patterns in Fibromyalgia Patients

Study Overview
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Brief Summary
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Fibromyalgia is a relatively young condition recently recognized by the WHO as a separated clinical entity. Part of the medical comunity thinks of it as a mixed condition between depresion and rheumatic pain, however, functional data provided by sophisticated imaging techniques points at a diminished brain activity in several brain regions. The present study aims to characterize those findings by means of QEEG in order to establish the electroencephalographic characteristics of fibromyalgia patients.

Detailed Description
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Fibromyalgia is a disease that part of the general population and even the medical community views with skepticism and only recently was accepted as a true condition by the World Health Organization. Some physicians see it as a form of depresion mixed with rheumatic pain. However recent findings in functional magnetic resonance imaging and positron emited tomography documented diminished brain activity on several regions. The impairments must be located within the areas with a documented functional defect, wherein, spontaneous braincells activity chould arise. Therefor electroencephalography findings should be a valuable diagnostic tool for early detection in fibromyalgia. The present study aims to analyse the differences between bioelectric characteristics in EEG from fibromyalgia patients with their eyes closed in a 21 electrode arragement. Normal graphoelements as well as abnormal ones and its topographic distribution and functional conections will be analyzed. The working hypotesis is that fibromyalgia patients will present distintive characteristics in the same areas where a diminished brain activity has been documented by metabolic and morphologic tests as a group and that those characteristics are suitable to be measured by QEEG and distinguishable from healthy subjects.

Official Title
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Quantitative and Qualitative EEG From Fibromyalgia Patients for the Identification of Abnormal Patterns on Closed Eyes EEG

Conditions
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Fibromyalgia

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men and women between 20 and 70 years old, diagnosed with fibromyalgia and a control group matched by age and gender Exclusion Criteria: Any other concomitant neurologic disease or impairment

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cases<br>Patients with a fibromyalgia diagnosis established according to the American College of Rheumatology current criteria by a trained physician. | |
| Controls<br>Healthy subjects paired by age and gender to the subjects in the cases group. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differences between groups in Fast Fourier Transformation | Changes in Power in EEG over different electrodes | Up to one year | 
| Topographic distribution of the frequency bands | Brain areas with a characteristic pattern | Up to one year | 
| Dominant EEG frequency localization | To document the dominant frequency in the resting EEG for all subjects | Up to one year | 
| Abnormal EEG-graphoelements description | To identify the abnormal EEG-graphoelements found in fibromyalgia patients | Up to one year | 
| Functional conectivity | To identify the different brain connections between fibromyalgia patients | Up to one year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Fibromyalgia, QEEG, Brain activity, fMRI, Diagnosis