Comparison of Analgesic Consumption Between Perioperative ıv Dexamethasone and Added to Femoral Block

Study Overview
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Brief Summary
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the aim of this study was to investigate compare the effect of peroperative intravenous single dose dexamethasone and the addition of dexamethasone to femoral nerve block on postoperative analgesic consumption and patient comfort in unilateral total knee arthroplasty patients

Detailed Description
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Total knee arthroplasty leads to severe postoperative pain. for postoperative pain control after total knee arthroplasty oral -intramuscular opioids ,patient controlled analgesia intravenous or epidural opioids, single -continuous femoral nerve block involving techniques are used. Dexamethasone is a glucocorticoid of high potency and frequently used perioperative.Dexamethasone to the local anaesthetic solution administered trough in femoral nerve blocks significantly prolonged the analgesic effect of the local anaesthetics used on this blocks.If the analgesic efficacy of systemic treatment with dexamethasone is similar with the use of perineural wich is the safest way should be preferred for systemic use.

Official Title
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The Compare the Effect of Peroperative Intravenous Single Dose Dexamethasone and the Addition of Dexamethasone to Femoral Nerve Block on Postoperative Analgesic Consumption Anf Patient Comfort in Unilateral Total Knee Arthroplasty Patients

Conditions
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Postoperative Pain

Intervention / Treatment
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* Drug: iv dexamethasone
* Drug: femoral dexamethasone
* Drug: serum physiologic


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: between 18-65 age knee arthroplasty no known allergies to drugs ASA 1-2 patients Exclusion Criteria: history of diabetes history of chronic pain treatment pregnancy severe bronchopulmonary disease systemic opioid and steroid use

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: iv dexamethasone<br>perioperative 2ml 8 mg ıv dexamethasone | Drug: iv dexamethasone<br>* 2 ml 8 mg iv dexamethasone<br>* Other names: decort;|
| Active Comparator: femoral dexamethasone<br>femoral block was performed postoperative 30 ml 0,5 % bupivacaine added 2 ml 8 mg dexamethasone | Drug: femoral dexamethasone<br>* 2ml 8mg dexamethasone administration added 30 ml 0,5 % bupivacain<br>* Other names: dekort;|
| Placebo Comparator: serum physiologic<br> | Drug: serum physiologic<br>* 2 ml iv serum physiologic<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| visual analog scale |  | postoperative 2 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| analgesic consumption | morphine consumption (patient controlled analgesia procedure) | postoperative 2 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dexamethasone, femoral block, total knee arthroplasty