Immunological Response After Shrimp Oral Immunotherapy Treatment

Study Overview
=================
Brief Summary
-----------------
Oral immunotherapy is effective in desensitized food allergy. Shrimp allergy is increasing in Thailand. So the purpose of our study is to determine level of specific immunoglobulin E antibodies to shrimp, Immunoglobulin G4 and immunoblot analysis in shrimp allergy patients after shrimp oral immunotherapy.

Detailed Description
-----------------
All subject in this study were sensitized to shrimp. All patient was clinically evaluated, with focus on shrimp allergy by medical history, medical examination and gold standard oral food challenge test. Compare oral immunotherapy to shrimp and shrimp avoidance. Blood sample was taken for baseline determination of immunoglobulin E antibodies to shrimp. The primary outcome was the specific immunoglobulin E antibodies to shrimp,Immunoglobulin G4 and immunoblot analysis in case that oral immunotherapy.

Official Title
-----------------
Immunological Response After Shrimp Oral Immunotherapy Treatment

Conditions
-----------------
Allergy to Shrimp, Immunotherapy

Intervention / Treatment
-----------------
* Other: shrimp allergy with intend to eat shrimp


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 12 - 40 years old History of Immunoglobulin E-mediated shrimp allergy > 3 episode/year or disturb quality of life Positive oral food challenge test for shrimp Exclusion Criteria: History of shrimp anaphylaxis (include cardiovascular or neurological symptoms) Shellfish dependent exercise induced anaphylaxis History of cardiovascular disease, uncontrolled asthma, severe atopic dermatitis History of Beta-blocker, Angiotensin-converting enzyme inhibitor, Angiotensin receptor blocker, Calcium channel blocker

Ages Eligible for Study
-----------------
Minimum Age: 12 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Shrimp allergy with Intend to eat shrimp<br>Case shrimp Immunoglobulin E mediated allergy and intend to eat shrimp and start oral immunotherapy for shrimp | Other: shrimp allergy with intend to eat shrimp<br>* shrimp allergy with intend to eat shrimp and treat with oral immunotherapy<br>|
| No Intervention: Shrimp allergy with avoid shrimp<br>Case shrimp allergy with avoid shrimp | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| specific Immunoglobulin E, Immunoglobulin G4, immunoblot analysis from Desensitized to shrimp allergen | To follow-up the level of specific Immunoglobulin E, Immunoglobulin G4, immunoblot analysis from Desensitized to shrimp allergen | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adverse event from Shrimp oral immunotherapy | To follow up adverse event from Shrimp oral immunotherapy | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Shrimp allergy, Oral immunotherapy, Specific Immunoglobulin E, Skin sensitization