Fermented Grape Combined With Fruits and Vegetables Drink on Anti-aging and Anti-inflammatory

Study Overview
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Brief Summary
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60 subjects were recruited and divided into placebo group and fermented grape drinks group.

Detailed Description
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In this study, using a fermented grape drinks made of fermented grapes with fruit and vegetable powder to explore whether it can improve the skin's condition and achieve anti-inflammatory effects. Sixty subjects were recruited and divided into placebo group and fermented grape drinks group. After drinking for 8 weeks, skin test and blood biochemical analysis were performed.

Official Title
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Fermented Grape Drinks Made of Fermented Grapes With Fruit and Vegetable Powder to Explore Whether it Can Improve the Skin's Condition and Achieve Anti-inflammatory Effects.

Conditions
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Skin Condition

Intervention / Treatment
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* Dietary Supplement: placebo group
* Dietary Supplement: fermented grape drinks


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Dry skin. Rough skin Large pores Dark yellow complexion Sagging skin Exclusion Criteria: Skin disorders Liver diseases Kidney diseases Allergy to cosmetics, drugs, or foods Pregnant and lactating women People who had any cosmetic procedures before 4 weeks of the study Area of facial spot over 3 cm2 Vegan People who took collagen supplements in the past 3 months.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: placebo group<br>subjects drank 50 ml , 1 bottle a day for 8 week | Dietary Supplement: placebo group<br>* subjects drank 50 ml , 1 bottle a day for 8 week<br>|
| Experimental: fermented grape drinks<br>subjects drank 50 ml , 1 bottle a day for 8 week | Dietary Supplement: fermented grape drinks<br>* subjects drank 50 ml , 1 bottle a day for 8 week<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| skin brightness | The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then using corneometer CM825 to examine skin brightness (The higher the value, the more water content, C.U., corneometer units ) | 8 week | 
| skin elasticity | The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then using cutometer dual MPA580 to examine skin elasticity (The closer the R2 value is to 1, the better the elasticity and no unit) | 8 week | 
| skin moisture | The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then using probe system GL2000 & MPA10 to examine skin moisture (The higher the value, the higher the gloss, no unit) | 8 week | 
| skin spot | The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then usig VISIA-CR to examine skin spot (The higher the value, the larger the pore area, mm2) | 8 week | 
| skin wrinkle | The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then using VISIOSCAN-VC20 to examine skin wrinkle (The higher the value, the more wrinkles, surface evaluation of wrinkles, SEW) | 8 week | 
| inflammatory cytokines | The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then using ELISA kit to examine inflammatory cytokines (pg/ml) | 8 week |