Study on the Effect of Fish Oil and Appetite

Study Overview
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Brief Summary
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20 normal-weight healthy subjects (10 males, 10 females) were in two periods given 10 of 0.5-mL capsules/day of fish oil and soybean oil for 3 weeks. In the end of each period they were given a standard breakfast and asked to report their appetite on visual analogue scales (VAS) immediately before and after the meal. The results were analyzed in accordance with the paired design under consideration of both supplement sequence and gender.

Detailed Description
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In a randomized cross-over design, 20 normal-weight healthy subjects (10 males, 10 females) were given 10 of 0.5-mL capsules/day of fish oil and soybean oil for 3 weeks. In the end of each period they were given a standard breakfast and asked to report their appetite on visual analogue scales (VAS) immediately before and after the meal. The results were analyzed in accordance with the paired design under consideration of both supplement sequence and gender.

Official Title
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Study on the Effect of Fish Oil and Appetite

Conditions
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Obesity, Cachexia

Intervention / Treatment
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* Dietary Supplement: Fish oil


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Normal weight (18.5<BMI<25 kg/m2). Healthy. Exclusion Criteria: Subjects taking medication that could influence appetite. Subjects with special nutritional needs e.g. pregnant and lactating, seriously ill or old people. Subjects that had had fish oil-supplements for four weeks prior to the intervention period.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Fish oil<br>5 g/d in 10 capsules, providing 3.5 g of long-chain n-3 fatty acids | Dietary Supplement: Fish oil<br>* For 3 weeks 5 g/d in 10 capsules, providing 3.5 g long-chain n-3 fatty acids in the fish oil period. Cross-over between arms with 1 week of wash out<br>|
| Placebo Comparator: Soy bean oil<br>5 g/d in 10 capsules | Dietary Supplement: Fish oil<br>* For 3 weeks 5 g/d in 10 capsules, providing 3.5 g long-chain n-3 fatty acids in the fish oil period. Cross-over between arms with 1 week of wash out<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Appetite and satiation | Appetite and satiation were measured by visual analogue scales (VAS), which assessed satiation, hunger, fullness and desire to eat. Each scale was 100 mm in length with words anchored at each end, expressing the most positive and negative rating of each category. | October 7th - November 25th 2011 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Weight change | Body weight was measured on the same scale without shoes and wearing light clothing in the morning before breakfast. | October 7th - November 25th 2011 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Appetite, Fish oil, Long-chain n-3 fatty acids