linjc16/ctgov huggingface dataset:
Capnography in Neonates Ventilated With High Frequency Ventilation: Prospective, Observational Multi-Center Study

Study Overview
=================
Brief Summary
-----------------
This will be an observational study. Respiratory data will be recorded using Capnostream20p. There will be no use in the recorded data for the medical care of the patients. Other clinical data will be captured in the CRF. Similar study is currently conducted in Bnai Zion MC since 2008. Thirty four (34) patients have been recruited without any adverse events. During the study the medical team will capture in the CRF the following: Blood gas and distal capnography values at time of sampling, ventilator settings at time of sampling. Changes made in the ventilation parameters, blood gas time and results, concomitant treatment (e.g. suction) and concomitant medication (respiratory related e.g. surfactant), vital signs all these will be retrieved from the patient's medical charts.

Official Title
-----------------
Capnography in Neonates Ventilated With High Frequency Ventilation: Prospective, Observational Multi-Center Study

Conditions
-----------------
Intubated Neonates That Require High Frequency Ventilation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Intubated neonates with double-lumen ETT (Uncuffed Tracheal Tube, Mallinckrodt Inc., Chih, Mexico) Neonates that their respiratory condition requires HFV Neonates expected to have at least 3 pairs of distal capnography measurements and blood gas samplings. Exclusion Criteria: Intubated neonates with single-lumen ETTs Neonates who are ventilated with conventional ventilation Any significant medical condition which, at the investigator's discretion, may interfere with the study.

Ages Eligible for Study
-----------------
Minimum Age: 1 Day

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Open<br>open, observational study | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluate the feasibility of measuring distal capnography on HFV and to assess its correlation and agreement with PaCO2 in infants ventilated with HFV in a prospective study. |  | August 2012 - February 2015 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Capnography, CO2, neonates, High Frequency ventilation (HFV)
Periodic Limb Movements Among Dialysis and Non-dialysis Chronic Kidney Disease Patients

Study Overview
=================
Brief Summary
-----------------
Periodic leg movement disorder is defined as periodic episodes of repetitive limb movements during sleep that mainly occur in the lower limb, including the hips, knees and toes and sometimes affects the upper limb. It may be accompanied by frequent nocturnal arousals, and if so, this sleep disturbance may cause excessive daytime sleepiness. Chronic kidney disease patients are at risk of periodic leg movements and common causes are iron deficiency, anemia, raised serum calcium and central and peripheral nervous system disorders.

Official Title
-----------------
Periodic Limb Movements Among Dialysis and Non-dialysis Chronic Kidney Disease Patients

Conditions
-----------------
The Aim of the Study Was to Screen Prevalence of Periodic Limb Movements Among Chronic Kidney Disease Patients

Intervention / Treatment
-----------------
* Diagnostic Test: Polysomnography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: chronic kidney disease Exclusion Criteria: diabetic, hepatic and chrest disease patients
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Diagnostic Polysomnography<br> | Diagnostic Test: Polysomnography<br>* Full night attended polysomnography to diagnose periodic limb movements<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Periodic limb movement | Screening the prevalence of periodic limb movement | One night |
Intrastromal Corneal Ring Segment Implantation in 219 Keratoconic Eyes at Different Stages

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to properly analyse the visual and refractive outcomes of implantation of KeraRing intrastromal corneal ring segment (ICRS) at the different stages of keratoconus.

Official Title
-----------------
Intrastromal Corneal Ring Segment Implantation in 219 Keratoconic Eyes at Different Stages

Conditions
-----------------
Keratoconus

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients who had keratoconus Contact lens intolerance and clear cornea. The maximum keratometric reading was less than 60.00 diopters (D) The minimum corneal thickness more than 300 μm. Exclusion Criteria: Acute or grade IV keratoconus. Previous corneal or intraocular surgery. Cataract, history of glaucoma or retinal detachment, macular degeneration or retinopathy, neuro-ophthalmic diseases, and history of ocular inflammation

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| keratoconus stage I in whom KeraRing ICRS were implanted<br> | |
| keratoconus stage II in whom KeraRing ICRS were implanted<br> | |
| keratoconus stage III in whom KeraRing ICRS were implanted<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Keratoconus, intrastromal corneal ring segment, To evaluate the visual and refractive outcomes of intrastromal corneal ring segment in keratoconic eyes at different stages
Etiology Of Recurrent Varicose Veins After Stripping Or Ablation Of Superficial Venous System

Study Overview
=================
Brief Summary
-----------------
Number of patients and causes and patterns of recurrent varicose veins in the lower limbs in patients with history of varicose veins stripping or ablation of the superficial venous system.

Detailed Description
-----------------
Recurrence of varicose veins following surgery is a common, complex and costly problem in vascular surgery. Despite improvements in preoperative evaluation and methods of treatment, recurrence following varicose vein surgery is reported to occur in between 20 and 80% of cases. Many theories have been put forward concerning the underlying mechanisms and causes. These include poor understanding of the venous anatomy and haemodynamics, inadequate preoperative assessment, inappropriate or incomplete surgery and development of new sites of venous reflux as a consequence of disease progression or neovascularisation. However, it is difficult to evaluate these suggestions since the studies from which they arise vary greatly in their definitions of recurrence, preoperative assessment, initial treatment, classification and method and duration of follow-up.

Official Title
-----------------
Etiology Of Recurrent Varicose Veins After Stripping Or Ablation Of Superficial

Conditions
-----------------
Recurrent Varicose Vein of Lower Limb (Disorder)

Intervention / Treatment
-----------------
* Diagnostic Test: DUS


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1) Ages eligible for the study: 18-60. 2) Sexes eligible for the study: All. 3) Patients with previous intervention for varicose veins. 4) Patients with primary or secondary varicosities. 5) Patient's compliance to follow-up. Exclusion Criteria: 1) Patients with no history of interventions for varicose veins. 2) Patients treated with injection sclerotherapy alone. 3) Pregnant women. 4) Patients with arterial disease in the same limb (ABI <0.8). 5) Patients with post-thrombotic syndrome -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: DUS|Duplex ultrasound|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Etiology of recurrence of varicose veins in patients previously treated by stripping and ligation or endovenous ablation. | Track the recurrence of varicose veins after intervention | Five years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of life was assessed by the Aberdeen Varicose Vein Questionnaire (AVVQ) |  | Five years |
The Effect of Relaxation Response Training on Declarative Memory and Learning in High School Students

Study Overview
=================
Brief Summary
-----------------
Stress contributes to health and behavioral issues in students, but will not be integrated into schools without evidence of benefit. This study was conducted to determine if a 6-week relaxation response (RR) curriculum improves cognitive performance in ninth grade students.

Detailed Description
-----------------
Stress contributes to health and behavioral issues in students, but will not be integrated into schools without evidence of benefit. This study was conducted to determine if a 6-week relaxation response (RR) curriculum improves cognitive performance in ninth grade students.

Official Title
-----------------
The Effect of Relaxation Response Training on Declarative Memory and Learning in High School Students

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Behavioral: Relaxation Response


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: a member of 9th grade at a residential preparatory school. Exclusion Criteria: none
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Relaxation Response|Relaxation training|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determine if a 6-week relaxation response (RR) curriculum improves cognitive performance. |  | 6 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluate whether the program would influence levels of salivary cortisol and whether there would be a correlation between cortisol levels and performance on the cognitive tasks. |  | 6 weeks |
Human Fibrinogen Concentrate (FGTW) in Pediatric Patients With Congenital Fibrinogen Deficiency

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to evaluate clinical pharmacology, efficacy and safety of FGTW in pediatric patients with congenital fibrinogen deficiency.

Official Title
-----------------
Clinical Pharmacology, Efficacy and Safety Study of FGTW in Paediatric Patients With Severe Congenital Fibrinogen Deficiency

Conditions
-----------------
Hypofibrinogenemia, Congenital, Afibrinogenemia, Congenital

Intervention / Treatment
-----------------
* Drug: biological: human fibrinogen concentrate


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Signed and dated informed consent form by parents or a legal representative Age less or equal to 12 years old Patients with inherited afibrinogenemia or severe inherited hypofibrinogenemia Negative results on HCG-based pregnancy test for females of childbearing potential (presence of menstruation) Exclusion Criteria: Dysfibrinogenemia Acquired fibrinogen deficiency Suspected present or past anticoagulation inhibitor Personal history of venous or arterial thrombosis or thromboembolic event Co-morbidity with other/unrelated coagulopathies Administration of any fibrinogen concentrate or fibrinogen containing blood product during the last 15 days Permanent treatment with antithrombotic or anti-platelet agents such as heparins, anti-IIa or anti-Xa agents, aspirin, clopidogrel and NSAIDs.

Ages Eligible for Study
-----------------
Maximum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: FGTW<br> | Drug: biological: human fibrinogen concentrate<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Investigator's overall assessment of efficacy of FGTW on hemostasis using a 4-point scale at the end of each bleeding or surgical episode. |  | 6 hours or up to 5 days | 
| Terminal half life for Fibrinogen antigen and activity |  | 5 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adverse Events |  | Participants will be followed for the duration of their participation in the study, an expected average of 1 year |
FH Detection in Children by Salivary Test

Study Overview
=================
Brief Summary
-----------------
Familial Hypercholesterolemia is a common cause of premature coronary heart disease, it is present in 1 per 500 to 1 per 250 people of the general population. Studies on families of Hypercholesterolemia have shown that children with Hypercholesterolemia have a major increase in risk of coronary heart disease after the age of 20. The difference between Hypercholesterolemia and normal children in their atherogenic profil begin at the age of Nowadays , systematic screening techniques are not well implemented whereas their are clear World health organization guidelines. International studies show treatment must be initiated early as at the age of eight years old. In pediatry, Parents can be reluctant to practice blood test on their children. In order to allow more patients to be diagnosed and treated early enough to prevent major complications we need to find an non invasive test. The main objective is to define the level of detection of cholesterol in saliva with two enzymatic tests. Furthermore we aim to evaluate the performance of salivary detection of cholesterol in children.

Official Title
-----------------
Familial Hypercholesterolemia Non Invasive Detection in Children by Salivary Test

Conditions
-----------------
Hyperlipoproteinemia Type II

Intervention / Treatment
-----------------
* Biological: salivary sample
* Biological: blood test


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria : children under 18 years old, with familial hypercholesterolemia children under 18 years old, intending surgery being able to spit Exclusion Criteria: poor dental health for control patients: to have a known cholesterol disease

Ages Eligible for Study
-----------------
Minimum Age: 2 Years
Maximum Age: 17 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Familial Hypercholesterolemia children<br> | Biological: salivary sample<br>* spit of saliva in a tube<br>Biological: blood test<br>* 2millilitter blood test<br>|
| Control children<br> | Biological: salivary sample<br>* spit of saliva in a tube<br>Biological: blood test<br>* 2millilitter blood test<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| salivary cholesterol concentration | the sample will be obtained during one visit non dedicated to this study (following-visit in nutrition for hypercholesterolemia children and before surgery for control children), the swabs of all the 60 patients will be used in two different methods of enzymatic tests. | Day 1 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
familial hypercholesterolemia, Healthy Volunteers
Microbiome Analysis of Skin and Airway Samples and Effect of Face Masks

Study Overview
=================
Brief Summary
-----------------
The goal of this study is to optimize two methods for microbiome analysis of skin and upper airway samples (16S amplicon sequencing and Shotgun sequencing). In addition, the researchers will investigate whether there is an effect of wearing a face mask on the microbial communities of the skin and upper airways. The volunteers will self-collect swabs of the skin and upper airways (nose and/or throat). Bacterial DNA and/or total RNA will be isolated and the microbial communities will be investigated with 16S amplicon sequencing and shotgun metagenomic sequencing.

Official Title
-----------------
Effect of Face Masks on the Microbial Communities of the Skin and Upper Airways and the Optimalisation of Microbiome Analysis

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Other: Observational intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult age 18 at the start of the study Exclusion Criteria: Pregnant women

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No face mask<br>Volunteers who did not wear a face mask | Other: Observational intervention<br>* Voluntarily (not) wearing a face mask (cotton or surgical) for 4 hours, following the government's guidelines during the COVID-19 pandemic.<br>|
| Cotton face mask<br>Voluntarily wearing a cotton face mask for 4 hours, following the government's guidelines during the COVID-19 pandemic. | Other: Observational intervention<br>* Voluntarily (not) wearing a face mask (cotton or surgical) for 4 hours, following the government's guidelines during the COVID-19 pandemic.<br>|
| Surgical face mask<br>Voluntarily wearing a surgical face mask for 4 hours, following the government's guidelines during the COVID-19 pandemic. | Other: Observational intervention<br>* Voluntarily (not) wearing a face mask (cotton or surgical) for 4 hours, following the government's guidelines during the COVID-19 pandemic.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in microbiome composition of the skin and upper airways after wearing a face mask | 16S rRNA sequencing | Start, 4 hours | 
| Optimalization of microbiome analysis of skin and upper airway samples | 16S rRNA sequencing, shotgun metagenomic sequencing | Start | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
skin microbiome, 16S amplicon sequencing, face masks, upper airway microbiome, shotgun sequencing
Retrospective Study on the Evolution of CIN 1 to 3 in Per and Postpartum in Nancy From 2014 to 2022

Study Overview
=================
Brief Summary
-----------------
In France, the screening rate for cervical cancer remains too low. Screening is simple and non-invasive. Pregnant patients are most of the time young and are part of the target population for screening, and for many women, it is the first encounter with a gynecologist. The cervical smear is therefore an important step of the first consultation during pregnancy In the case of pathological results, colposcopies with biopsies are performed, frequently finding CIN 1 to 3. (cervical intraepithelial neoplasia) These CIN lesions evolve slowly and most of the time, treatment can be withheld until the end of the pregnancy. Several studies suggest a higher regression rate in pregnant patients. Our study will evaluate the rate of regression, progression or persistence of these lesions in per and post partum patients in Nancy, between 2014 and 2022. To obtain our results, we will compare the results of per and post partum biopsies in each patient. In a second step, we will study the risk factors of aggravation or on the contrary the protective factors, allowing a faster regression of the lesions

Official Title
-----------------
Retrospective Study on the Evolution of CIN 1 to 3 in Per and Postpartum in Nancy From 2014 to 2022

Conditions
-----------------
Cervical Intraepithelial Neoplasia

Intervention / Treatment
-----------------
* Biological: cervical biopsy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: women who have a CIN lesion during pregnancy in Nancy, France, MRUN Center between 2014 and 2022 Exclusion Criteria: lost of follow up women
Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with CIN lésions during pregnancy<br> | Biological: cervical biopsy<br>* cervical biopsy made during and after pregancy<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| progress, persistence or regression of CIN lesion count | cervical biopsy | up to one year after delivery |