Preoperative Evaluation of the Remaining Part of the Liver for Liver Resection

Study Overview
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Brief Summary
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Review the outcomes of the current treatments modalities. Give an effective treatment . Improve the outcome of these patients and decease rate of recurrence and complications. An adequate future liver remnant (FLR) reduces the risk of postoperative liver failure after major hepatectomy. incurs a risk of postoperative liver dysfunction and infection and there is a lack of objective evidence relating residual liver volume to these complications

Detailed Description
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A liver resection is the surgical removal of all or a portion of the liver. It is also referred to as a hepatectomy, full or partial. A complete liver resection is performed in the setting of a transplant a diseased liver is removed from a deceased donor (cadaver). A living donor may also provide a piece of liver tissue which is procured through a partial hepatectomy, The procedure may be performed through a traditional open procedure or using minimally invasive techniques. When is Liver Resection Performed Most hepatectomies are performed for the treatment of hepatic neoplasms, both benign or malignant. Benign neoplasms include hepatocellular adenoma, hepatic hemangioma and focal nodular hyperplasia.The most common malignant neoplasms (cancers) of the liver are metastases; those arising from colorectal cancer are among the most common, and the most amenable to surgical resection. The most common primary malignant tumour of the liver is the hepatocellular carcinoma. Hepatectomy may also be the procedure of choice to treat intrahepatic gallstones or parasitic cysts of the liver. Liver surgery is safe when performed by experienced surgeons with appropriate technological and institutional support. As with most major surgical procedures, there is a marked tendency towards optimal results at the hands of surgeons with high caseloads in selected centres (typically cancer academic medical centers and transplantation centers). Partial hepatectomy is surgery to remove part of the liver. Only people with good liver function who are healthy enough for surgery and who have a single tumor that has not grown into blood vessels can have this operation. Imaging tests, such as CT or MRI with angiography are done first to see if the cancer can be removed completely. Still, sometimes during surgery the cancer is found to be too large or has spread too far to be removed, and the surgery that has been planned cannot be done. Can a portion of the remaining normal liver grow back? When a portion of a normal liver is removed, the remaining liver can grow back (regenerate) to the original size within several weeks. A cirrhotic liver, however, cannot grow back. Therefore, before resection is performed for HCC, the non-tumor portion of the liver should be biopsied to determine whether there is associated cirrhosis.

Official Title
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Preoperative Evaluation of the Remaining Part of the Liver for Liver Resection

Conditions
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Liver Diseases

Intervention / Treatment
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* Diagnostic Test: resection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients undergoing liver resection for benign or malignant hepatic neoplasm at the time of study(two years) Patient consent. Age of the patient : Any age Exclusion Criteria: patients has contraindication to do liver resection surgery. patients who are unfit for any surgical interventions. patients who refuse the operation or refusing to share his data.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: patient under going liver resection<br> | Diagnostic Test: resection<br>* CT volumetry,liver function,biopsy before resection<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation | Evaluation of the remaining part of the liver by CTvolumetry for further management as liver transplant | preoperative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| energy expenditure | Change in total energy expenditure (Kcal) following liver resection | [ Time Frame: 30 days ] | 
| Procedural parameters | including intraoperative blood loss | intraoperative | 
| Long-term outcomes | 5-year tumor recurrence rate | 5 years | 
| Perioperative liver function | including serum levels of alanine aminotransferase (ALT) | 30 days preoperative |