linjc16/ctgov huggingface dataset:
18F-FLT PET for Suspicious Findings on Mammography and Breast Ultrasound

Study Overview
=================
Brief Summary
-----------------
The purpose: To investigate the diagnostic accuracy of 18F-FLT PET for the suspicious lesions on mammograms and ultrasound.

Detailed Description
-----------------
To investigate the diagnostic accuracy of 18F-FLT PET for the suspicious lesions on mammograms and ultrasound, using the pathologic result of biopsy as gold standard, and to determine whether 18F-FLT PET can increase the specificity in breast lesion diagnosis and thus reduce the unnecessary biopsy. To evaluate whether 18F-FLT PET is a cost-effective imaging modality for breast cancer diagnosis.

Official Title
-----------------
Use of 18F-FLT Positron Emission Tomography to Evaluate the Suspicious Findings on Mammography and Breast Ultrasound: A Pilot Study

Conditions
-----------------
Breast Neoplasms

Intervention / Treatment
-----------------
* Drug: 18F-FLT


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Women aged between 20 to 80 years women who have localized findings on mammography and / or ultrasound and will receive biopsy. The lesions on the conventional imaging measure >=1cm WBC count >=3000/L, or platelet>=75,000/L Liver function, AST or ALT < 78 U/L Renal function, Creatinine < 2.0 mg/dl.The laboratory examinations should be performed within 4months before our study. Exclusion Criteria: Pregnant women or who are planning to be pregnant. Known cancers in other organs. Women who are not able to cooperate with the PET/CT examination.

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: 18F-FLT<br>18F-FLT PET for Suspicious Findings on Mammography and Breast Ultrasound. | Drug: 18F-FLT<br>* 0.07 mCi/kg of 18F-FDG will be injected intravenously. The data acquisition will be started at 90 minutes after the injection using 2-D acquisition from a GE DISCOVERY ST PET/CT scanner (GE Medical Systems, Milwaukee, WI).<br>* Other names: FLT;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To investigate the diagnostic accuracy of 18F-FLT PET for the suspicious lesions on mammograms and ultrasound, using the pathologic result of biopsy as gold standard. |  | The biopsy procedures will be scheduled as soon as possible and should be finished within 2 months after 18F-FLT PET. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
FLT PET, breast neoplasms, mammography, breast ultrasound
Risperidone for the Treatment of Cocaine Dependence - 7

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate clinical safety and pharmacological efficacy in the treatment of cocaine dependence, to evaluate impact of treatment on craving, and to correlate evidence of baseline neurotoxic damage of cocaine with treatment outcome and clinical side-effects.

Official Title
-----------------
Risperidone for the Treatment of Cocaine Dependence

Conditions
-----------------
Cocaine-Related Disorders

Intervention / Treatment
-----------------
* Drug: Risperidone


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: M/F ages 21-50. Meet DSM-IV criteria for cocaine dependence. Agree to conditions of the study and sign informed consent. Exclusion Criteria: Psychiatric disorder that requires medication therapy. History of seizures. Pregnant and/or nursing women. Dependence on ETOH or benzodiazepines or other sedative/hypnotics. Acute hepatitis. Other medical conditions that deem participation to be unsafe.

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Risperidone|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cocaine dependence
A Trial to Compare Pringle Maneuver With Either Infrahepatic Inferior Vena Cava Clamping or Low Central Venous Pressure

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to better comprehend the benefits and efficacy of portal triad clamping with infrahepatic IVC clamping during complex hepatectomy. A randomized comparative trial was performed to compare PTC(pringle triad clamping) with either infrahepatic IVC clamping or low central venous pressure in complex liver resections.

Detailed Description
-----------------
To better comprehend the benefits and efficacy of portal triad clamping with infrahepatic IVC clamping during complex hepatectomy. A randomized comparative trial was performed to compare PTC with either infrahepatic IVC clamping or low central venous pressure in complex liver resections. 192 consecutive patients were involved in this study and allocated equally to two groups. Preoperative demographic and clinical data, details of surgical procedure, pathologic diagnosis, postoperative course and complications were collected prospectively.

Official Title
-----------------
A Prospective Randomized Comparative Trial to Compare Pringle Maneuver With Either Infrahepatic Inferior Vena Cava Clamping or Low Central Venous Pressure in Complex Liver Resections

Conditions
-----------------
Liver Resection

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients who were assessed by preoperative medical imagings to have a high risk of backflow bleeding from the major hepatic veins and the IVC, based on the size and location of the tumor. The tumors were ≥5 cm in diameter and they involved the liver segments 7, 8 and/or the cranial portion of segment 4. These tumors were in close proximity or were compressing, but had not actually invaded, the major hepatic veins or IVC Pugh-Child Grade A Indocyanine green retention rate at 15 minutes (ICGR15) < 10%; acceptable clotting profile (platelet count ≥ 50 ×109/L and prothrombin activity ≥ 60%) no previous liver resection. Exclusion Criteria: extrahepatic metastases in patients with malignancy; patients who refused to take part in this study.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
blood loss, hepatectomy, prospective study, PTC
A Retrospective Multicenter Study of HBV-related Pre-acute-on-chronic Liver Failure in China

Study Overview
=================
Brief Summary
-----------------
The definition and diagnostic criteria of Acute-on-chronic liver failure (ACLF) has been well established by EASL CANONIC study. However, patients with high risk to develop ACLF has not been determined, yet. The aim of current study is to establish a preliminary pre-ACLF definition, and to demonstrate the corresponding risk factors.

Official Title
-----------------
A Retrospective Multicenter Study of HBV-related Pre-acute-on-chronic Liver Failure in China

Conditions
-----------------
Liver Failure, Acute on Chronic, Liver Injury

Intervention / Treatment
-----------------
* Other: standard treatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Chronic hepatitis B virus infection; Any of the followings: Alanine aminotransferase (ALT)≥3 upper limit of laboratory reference (ULN); Aspartate aminotransferase (AST)≥3 ULN; Serum bilirubin≥2 ULN; Acute decompensation (ascites, hepatic encephalopathy, variceal hemorrhage and/or bacterial infections) Exclusion Criteria: Previous decompensation; those who had hepatocellular carcinoma or other types of malignancies; those who combined with severe chronic extra-hepatic disease; pregnant; received liver transplantation or kidney transplantation before or after admission; readmission; death within 24 hours.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: standard treatment|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 28-day ACLF progression | progressed to EASL defined ACLF | 28-day | 
| 28-day mortality | death within 28-day | 28-day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 90-day mortality | death within 90-day | 90-day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
pre-acute-on-chronic liver failure, hepatitis B
An Open, Multicenter, Randomized, Dose-Ranging Study of Azithromycin in the Treatment of Disseminated Mycobacterium Avium-Intracellulare Complex Infection (MAC) in Patients With Acquired Immune Deficiency Syndrome (AIDS)

Study Overview
=================
Brief Summary
-----------------
To evaluate the efficacy and safety of two doses of azithromycin given chronically for the treatment of Mycobacterium avium bacteremia in AIDS patients.

Official Title
-----------------
An Open, Multicenter, Randomized, Dose-Ranging Study of Azithromycin in the Treatment of Disseminated Mycobacterium Avium-Intracellulare Complex Infection (MAC) in Patients With Acquired Immune Deficiency Syndrome (AIDS)

Conditions
-----------------
Mycobacterium Avium-Intracellulare Infection, HIV Infections

Intervention / Treatment
-----------------
* Drug: Azithromycin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria Concurrent Medication: Allowed: Medications allowed under a Treatment IND program. Patients must have: HIV infection. Disseminated Mycobacterium avium Complex. Fever (> 100 degrees F) that cannot be attributed to another active infection, and at least one other constitutional symptom (such as fatigue, malaise, anorexia). Life expectancy of at least the duration of the study. Consent of parent or guardian if below the legal age of consent. Exclusion Criteria Co-existing Condition: Patients with the following symptoms and conditions are excluded: Known hypersensitivity or significant intolerance to macrolide antibiotics. Inability to take oral medications or a current condition likely to interfere with drug absorption (e.g., gastrectomy). Prior Medication: Excluded: Treatment with an immunostimulant or immunomodulator compound such as alpha-interferon, gamma-interferon, or any interleukin within 7 days prior to study entry. Any other antibiotic with known activity against M. avium within 7 days prior to study entry. Not expected to comply with the requirements of the protocol, in the opinion of the investigator.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Azithromycin|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Mycobacterium avium-intracellulare Infection, Acquired Immunodeficiency Syndrome, Azithromycin
Observation of Physiotherapy Treatment Sessions - Exploring What Happens in Physiotherapy for Patients After Stroke.

Study Overview
=================
Brief Summary
-----------------
This is the first phase of a study that will investigate the effects that different approaches to physiotherapy have on the expression of associated reactions. During this phase, current practice among neuro-physiotherapists will be explored in relation to: the learning strategies used in stroke rehabilitation, the common interventions used in gait re-education, and the strategies adopted for the assessment and management of associated reactions.

Detailed Description
-----------------
Associated reactions are unintended and involuntary arm movements, normally seen as bending of the wrist and elbow, that may occur after stroke when a person is doing something effortful such as walking. The objectives are: To provide an insight into the learning strategies used by physiotherapists during the re-education of walking, including the verbal dialogue that takes place and any preferences (overt or subconscious) adopted for one type of learning strategy. To develop and refine a description of what is meant by the term gait re-education To provide an insight into how therapists currently manage associated reactions This phase of the study will explore these objectives using direct non-participation observation of a number of physiotherapy treatment sessions. This will provide an insight into the nature of the therapy that takes place for retraining walking(e.g. the types of exercises commonly used) and the nature of the learning strategies frequently adopted, including the amount and content of explicit verbal instruction and feedback that is provided to patients.

Official Title
-----------------
Do Implicit and Explicit Learning Strategies Applied During Gait Re-education Influence Concurrent Expression of Associated Reactions in Individuals With Hemiplegia? Phase 1a

Conditions
-----------------
Stroke

Participation Criteria
=================
Eligibility Criteria
-----------------
has suffered a stroke is currently receiving active rehabilitation that includes gait re-education is exhibiting upper limb deficits is able to provide informed consent.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Infection in DiGeorge Following CHD Surgery

Study Overview
=================
Brief Summary
-----------------
We propose a retrospective review of patients with DiGeorge syndrome having undergone cardiac surgery to evaluate the incidence of blood stream and/or surgical site infection. The hypothesis is that we will find an increased number of infections for this sub-group. We will compare the incidence of infection to children of similar age and diagnosis to evaluate for variances in the incidence of infection.

Detailed Description
-----------------
DiGeorge syndrome is a common genetic disorder that frequently results in congenital heart defects such as truncus arteriousus, coarctation of the aorta, interrupted aortic arch, tetralogy of Fallot, pulmonary atresia with VSD, and several others. The defect is usually due to a deletion in the long arm of chromosome 22. Approximately 25% of patients with DiGeorge have a congenital heart defect. These patients also have varying degrees of thymic hypoplasia with associated T cell dysfunction. They are at increased risk of infections and can be at risk for opportunistic infections when the degree of T cell dysfunction is severe. Children undergoing cardiac surgery are at risk for infections in the post-operative period, prolonging hospital stay and increasing morbidity and mortality. The patient with DiGeorge syndrome may have higher rates of infection due to associated immune system dysfunction, however, this has not been previously reported from a large group of DiGeorge syndrome patients. Children's Healthcare of Atlanta follows over 200 patients with DiGeorge syndrome, with the majority having previously undergone cardiac surgery. This group of patients may benefit from more extensive antibiotic prophylaxis following surgery if they indeed have significantly higher rates of infection, but the true incidence needs to be determined.

Official Title
-----------------
Incidence of Infection in the Patient With DiGeorge Syndrome Following Surgery for Congenital Heart Disease

Conditions
-----------------
DiGeorge Syndrome, Congenital Heart Defects

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children's Healthcare of Atlanta patients, Egleston DiGeorge Syndrome Cardiac Surgery 200 medical charts between Jan 1, 1998 and April 31, 2005 with cardiac surgery and DiGeorge Syndrome 200 medical charts between Jan 1, 1998 and April 31,2005 with cardiac surgery and no DiGeorge Syndrome Exclusion Criteria: Those who do not meet inclusion criteria

Ages Eligible for Study
-----------------
Maximum Age: 15 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
pediatric, DiGeorge Syndrome, Congenital heart defects, Infections, Cardiac surgery
Registry-based Biobank Development and Integrative Physiological Analysis

Study Overview
=================
Brief Summary
-----------------
The purpose is to develop a registry-based biobank for integrative physiological analysis based on biological samples (blood, urine, interstitial fluid and muscle) from subjects enrolled in the Section registry, using multivariate and data-mining approaches that includes also clinical and demographic parameters

Official Title
-----------------
Registry-based Biobank Development and Integrative Physiological Analysis

Conditions
-----------------
Integrative Human Physiology

Intervention / Treatment
-----------------
* Other: Biobank development and integrative physiological analysis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: able to perform fatiguing exercise Exclusion Criteria: severe mental or physical handicap chronic disease deemed by the M.D. to preclude inclusion use of prescription medicine deemed by the M.D. to preclude inclusion

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Biobank development and integrative physiological analysis|Collection of biological samples (blood, urine, interstitial fluid, adipose tissue and muscle) from subjects enrolled in the Section registry, using multivariate and data-mining approaches that includes also clinical and demographic parameters.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Biobank creation | Collection of biological samples from subjects included in the Section Registry | through study completion, an average of 5 years |
Physical Fitness in Autism

Study Overview
=================
Brief Summary
-----------------
Although there are some studies investigating the physical activity levels of children with autism in the literature, no comprehensive study investigating the relationship between posture and physical fitness parameters, family anxiety level and quality of life of individuals with autism who have continued physical activity program has not been found. The aim of our study is to compare postural disorders and physical fitness parameters, family anxiety level and quality of life between individuals with autism and healthy individuals attending physical activity program.

Official Title
-----------------
Comparison of Postural Disorders and Physical Fitness Parameters, Family Anxiety Level and Quality of Life Between Individuals With Autism and Healthy Individuals Who Continue Physical Activity Program

Conditions
-----------------
Autism

Intervention / Treatment
-----------------
* Other: physical fitness assessment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Being diagnosed with mild to moderate autism, To have the ability to emulate, To have a cognitive level and cooperation capacity that will not hinder the implementation of assessment scales, Exclusion Criteria: Having any systemic chronic disease and neurological disorder During the last 6 months, individuals wih autism in the process will affect physical fitness for fracture, surgery and so on.

Ages Eligible for Study
-----------------
Minimum Age: 7 Years
Maximum Age: 17 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Autism<br>Assessment of physical activity level and physical fitness | Other: physical fitness assessment<br>* assessment<br>|
| Healthy<br>Assessment of physical activity level and physical fitness | Other: physical fitness assessment<br>* assessment<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physical fitness | Münich fitness test | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Posture analysis | New york posture analysis | 1 month | 
| Physical activity level | Godin leisure time activity questionnaire | 1 month | 
| Family Anxiety Level | State-Trait Anxiety Inventory: Scores range from 20 to 80. Scores are positively correlated with higher levels of anxiety | 1 month |