Insulin Sensitivity Response to High-Intensity Training in Insulin Resistance During Pregnancy

Study Overview
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Brief Summary
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Insulin Resistance is one of the common complications that occur during pregnancy. Early intervention is essential to prevent the development of the diseaseThere is evidence that physical inactivity increases the risk of a lot of adverse health problems, including coronary heart disease, type 2 diabetes, breast and colon cancers. It also shortens life expectancy. Pregnancy is a period in the life of women that is often associated with decreased daily physical activity and decreased participation in sports and exercise . In the first few weeks of pregnancy, maternal carbohydrate metabolism is affected by a rise in maternal levels of estrogen and progesterone that stimulates pancreatic β-cell hyperplasia and insulin secretion. As pregnancy progress, pancreatic islet cell hypertrophy continues and there is an increased insulin response to glucose or meal stimulation.

Detailed Description
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This study was carried out upon twenty multigravida pregnant female between 5-6 months gestation with IR calculated by HOMA test (fasting blood glucose× fasting insulin) ÷ 22.5. Fasting blood glucose was assessed by the method approved by (7, 13) .The test materials for this method were supplied as kits by Diamond Diagnostics, while Insulin concentrations were stated in formerly frozen and defrosted serum samples by enzyme immunoassay using the human Insulin ELISA kits.

Official Title
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Impact of High-Intensity Interval Training on Insulin Resistance During Pregnancy: A Randomized Control Trial.

Conditions
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High Intensity Interval Training, Diet, Healthy

Intervention / Treatment
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* Dietary Supplement: moderate restricted diet (1800-2000 kcal/day) for four weeks


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: forty multigravida females. their age ranged between 25 to 35 years old. Body mass index (BMI) <30kg/ m². Exclusion Criteria: females with pelvic pathology as endometriosis. females have irregular menstrual cycles.

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: group (A) received HIIT and low diet for four weeks, 3 sessions weekly. While the control group received diet only.
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: diet program<br>moderate restricted diet (1800-2000 kcal/day) for four weeks, 3 sessions weekly | Dietary Supplement: moderate restricted diet (1800-2000 kcal/day) for four weeks<br>* high intensity interval training 3 sessions for four weeks<br>* Other names: high intensity interval training;|
| Experimental: high intensity interval training<br>high intensity interval training for four weeks, 3 sessions weekly | Dietary Supplement: moderate restricted diet (1800-2000 kcal/day) for four weeks<br>* high intensity interval training 3 sessions for four weeks<br>* Other names: high intensity interval training;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fasting blood glucose level | Fasting blood glucose level were measured by expert specialist before and after intervention period from 24th to 37th weeks of pregnancy. | three months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fasting Insulin Level | Fasting blood insulin level were measured by expert specialist before and after intervention period from 24th to 37th weeks of pregnancy. | three months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Training, Insulin Resistance, Pregnancy