Effects of Anesthesia With Propofol Versus Desflurane in Obese Patients

Study Overview
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Brief Summary
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Evaluate the effects of propofol compared with desflurane on oxidative stress and inflammation markers in obese patients undergoing scheduled bariatric surgery.

Detailed Description
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Obese patients have a high level of oxidative stress and inflammation activity. Desflurane is an anesthetic gas often used for obese patients. Propofol, another anesthetic agent, has shown an antioxidant property. The aim of the study is to compare the effects of propofol with desflurane on oxidative stress and inflammation markers in obese patients.

Official Title
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Effects of General Anesthesia With Propofol Versus Desflurane on Oxidative Stress and Inflammation in Obese Patients Scheduled for Bariatric Surgery

Conditions
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Anesthesia, Obesity

Intervention / Treatment
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* Drug: Desflurane Inhalant Product
* Drug: Propofol


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Body Mass Index (BMI) >35 scheduled gastric by pass surgery American Society of Anesthesiologists (ASA) <III Exclusion Criteria: Allergic to anesthesia agent patient refusal

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Desflurane Inhalant Product Group<br>general anesthesia with desflurane | Drug: Desflurane Inhalant Product<br>* General anesthesia will be induced with sufentanyl (0.2µg/kg) and thiopental (5mg/kg) and maintained by desflurane<br>* Other names: Suprane;|
| Experimental: Propofol Group<br>general anesthesia with propofol | Drug: Propofol<br>* General anesthesia will be induced with propofol (2mg/kg) and sufentanyl (0.2µg/kg) and maintained by propofol in a target-controlled infusion mode<br>* Other names: Diprivan;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Malondialdehyde (MDA) level in blood sample | Plasma MDA level is measured as an oxidative stress marker before the surgery, at 1 hour, 2 hours, 24 hours post-surgical incision. | up to 24 hours post bariatric surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| C-Reactive Protein (CRP) in blood sample | Plasma CRP level is measured as an inflammation marker before the surgery, at 1 hour, 2 hours, 24 hours post-surgical incision. | up to 24 hours post bariatric surgery | 
| Monocyte level in blood sample | Monocyte level is measured as an inflammation marker before the surgery, at 1 hour, 2 hours, 24 hours post-surgical incision. | up to 24 hours post bariatric surgery | 
| Pain assessed by Visual Analog Scale (VAS) | Pain level is determined at 2 hours, 24 hours and 48 hours post-surgical incision. Visual analog pain score (scale = 0 no pain; 10= worst pain imaginable) | up to 48 hours after surgery | 
| Side-effects (nausea, vomiting, somnolence, respiratory depression) | Evaluation at 2 hours, 24 hours and 48 hours post-surgical incision | up to 48 hours after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Oxidative stress, Bariatric surgery