Effect of Physiological Ischemic Training on Patients With Atherosclerosis

Study Overview
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Brief Summary
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To study whether the resistance training with blood flow obstruction in patients in early atherosclerosis period can produce a beneficial effect on preventing atherosclerosis.

Official Title
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Effect of Physiological Ischemic Training on Patients With Atherosclerosis

Conditions
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Atherosclerosis

Intervention / Treatment
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* Behavioral: exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: LDL > 3.11mmol/l and less than 5.63mmol/l; No serious heart, blood vessel and other related diseases; There were no skeletal and muscular diseases affecting sports training; No regular exercise in the past half year (no more than 2 times a week, no more than 30 minutes each time); Smoking less than 1 pack / year, no history of drinking. Exclusion Criteria: Haven't other serious heart and vascular diseases other than hyperlipidemia and / or bones and muscles that affect sports training Diseases; Pregnant women and people with disabilities; Other circumstances determined by the researcher not suitable for the study.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Blank control group<br> | |
| Experimental: Exercise group<br> | Behavioral: exercise<br>* Upper limb resistance training with blood flow obstruction<br>|
| No Intervention: Hyperlipidemia group<br> | |
| No Intervention: Hyperlipidemia and medication group<br> | |
| Experimental: Hyperlipidemia and exercise group<br> | Behavioral: exercise<br>* Upper limb resistance training with blood flow obstruction<br>|
| Experimental: Hyperlipidemia and medication and exercise group<br> | Behavioral: exercise<br>* Upper limb resistance training with blood flow obstruction<br>|
| No Intervention: Routine treatment group<br> | |
| Experimental: Routine treatment and exercise group<br> | Behavioral: exercise<br>* Upper limb resistance training with blood flow obstruction<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Endothelium dependent vasodilation | Percentage of the change | 8 weeks | 
| Blood lipid analysis results | Content of total cholesterol, triglycerides, high density lipoprotein and low density lipoprotein | 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The inflammatory state | Content of NO, eNOS, iNOS, IFN-γ, IL-6, IL-10 in blood | 8 weeks | 
| Endothelial repair function | eNOSmRNA, iNOSmRNA, EPCs in blood | 8 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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resistance training