Healthcare-associated Infections in Severe COVID-19 During 2020

Study Overview
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Brief Summary
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In patients who develop ARDS due to SARS-CoV-2 (CARDS), a longer duration of invasive mechanical ventilation (IMV) and ICU stay has been reported compared to ARDS not associated with SARS-CoV-2. Consequently, the days of stay in ICU increase Identifying the risk factors associated with the development of this complication and developing measures aimed at its prevention could have a favorable impact on the clinical course of seriously ill patients.

Detailed Description
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The rate of catheter-associated bacteremia is 3.78 / 1000 days central venous catheters in polyvalent ICUs. Some studies suggest that in the context of this pandemic, infections associated with health care have increased, although there are few data referring to Latin America. The objective of this study is to analyze the incidence of health care associated infections in adult patients on invasive mechanical ventilation with confirmed COVID-19 diagnosis and negative COVID-19 admitted to the Intensive Care Unit of the Anchorena San Martín Clinic, San Martín, Buenos Aires.

Official Title
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Healthcare-associated Infections in Severe COVID-19 Patients Whit Mechanical Ventilation During 2020

Conditions
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Respiration, Artificial, COVID-19, Health Care Associated Infection

Intervention / Treatment
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* Other: COVID-19


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients older than 18 years admitted to the intensive care unit of the Anchorena San Martín Clinic who required invasive mechanical ventilation for more than 24 hours in a period between March 2020 and December 2020 were included in the analysis. Exclusion Criteria: All patients who presented incomplete data in the follow-up sheets were excluded.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COVID-19 patients<br>Patients with invasive mechanical ventilation admitted to the Intensive Care Unit (UCI) of the Anchorena San Martín Clinic, San Martín, Buenos Aires with confirmed COVID-19 diagnosis (positive polymerase chain reaction in nasopharyngeal swab). | Other: COVID-19<br>* Impact of covid-19 on infections associated with health care devices.<br>|
| non COVID-19 patients<br>Patients with invasive mechanical ventilation admitted to the Intensive Care Unit (UCI) of the Anchorena San Martín Clinic, San Martín, Buenos Aires with negative COVID-19 diagnosis (positive polymerase chain reaction in nasopharyngeal swab). | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of health care associated infections in each group. |  | March to December 2020 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The most frequent pathogens in this population associated with Incidence of health care associated infections. |  | March to December 2020 | 
| Possible factors associated with Incidence of health care associated infections. |  | March to December 2020 | 
| mortality in UCI |  | March to December 2020 | 
| Days of ICU stay |  | March to December 2020 | 
| Days of mechanical ventilation |  | March to December 2020 |