Impact of Preemptive Intravenous Ibuprofen on Intraoperative Analgesia in Third Molar Teeth

Study Overview
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Brief Summary
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This study was planned to evaluate the analgesic efficacy of preemptive intravenous (iv) ibuprofen on pain occurring during and after the mandibular third molar surgeon

Official Title
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Impact of Preemptive Intravenous Ibuprofen on Intraoperative Analgesia in Third Molar Teeth

Conditions
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Preemptive Intravenous Ibuprofen, Intraoperative Analgesia

Intervention / Treatment
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* Drug: arveles
* Drug: intrafen 800 mg
* Other: plasebos


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who are to be elected third molar tooth extraction Patients between the ages of 20-35 Patients who are symptomatic Third molar tooth angular or horizontal settled patients Exclusion Criteria: Patients who refuse to participate in the study Patients under 20 years old, over 35 years old Patients who are allergic to known non-steroidal anti-inflammatory drugs Pregnant patients Patients with severe liver failure, patients with severe renal insufficiency

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: arveles<br>Ibuprofen 800 mg in normal saline 150 cc and dexketoprofen (50 mg) before operation will be given in 30 minutes | Drug: arveles<br>* Intraoperative and postoperative pain values between these three groups will be compared.<br>* Other names: dexketoprofen;Drug: intrafen 800 mg<br>* ibuprofen 800 mg in normal saline 150 cc before operation will be given in 30 minutes. Intraoperative and postoperative pain values between these three groups will be compared.<br>* Other names: ibuprofen i.v.;Other: plasebos<br>* normal saline 150 cc before operation will be given in 30 minutes. Intraoperative and postoperative pain values between these three groups will be compared.<br>|
| Active Comparator: intrafen<br>intrafen 800 mg in normal saline 150 cc before operation will be given in 30 minutes | Drug: arveles<br>* Intraoperative and postoperative pain values between these three groups will be compared.<br>* Other names: dexketoprofen;Drug: intrafen 800 mg<br>* ibuprofen 800 mg in normal saline 150 cc before operation will be given in 30 minutes. Intraoperative and postoperative pain values between these three groups will be compared.<br>* Other names: ibuprofen i.v.;Other: plasebos<br>* normal saline 150 cc before operation will be given in 30 minutes. Intraoperative and postoperative pain values between these three groups will be compared.<br>|
| Placebo Comparator: plasebos<br>150 cc normal saline will be given in 30 minutes during preoperative period | Drug: arveles<br>* Intraoperative and postoperative pain values between these three groups will be compared.<br>* Other names: dexketoprofen;Drug: intrafen 800 mg<br>* ibuprofen 800 mg in normal saline 150 cc before operation will be given in 30 minutes. Intraoperative and postoperative pain values between these three groups will be compared.<br>* Other names: ibuprofen i.v.;Other: plasebos<br>* normal saline 150 cc before operation will be given in 30 minutes. Intraoperative and postoperative pain values between these three groups will be compared.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| intraoperative pain as assessed by visual analogue scale | Assessment of Preemptive intravenous ibuprofen on intraoperative analgesic efficacy in 3. molar tooth extraction | 5 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative pain as assessed by visual analogue scale | postoperative analgesic contribution of preemptively administered intravenous ibuprofen. | 5 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Intraoperative analgesia, Preemptive intravenous ibuprofen, Third molar tooth surgery