Subjects With T2D or at Risk of T2D Cohort Follow-up

Study Overview
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Brief Summary
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The main objective of this study is to prospectively follow the subjects included in Descendance cohort and to describe the occurrence of type 2 diabetes in non-diabetic subjects, which will allow us to iteratively update the Descendance Type 2 Diabetes risk prediction model.

Detailed Description
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High risk families will be prospectively follow in order to better understand the risk of transmission of type 2 diabetes from one generation to another. The cohort will also allow us to collect additional data on diabetic patients. The monitoring of the cohort will take place for at least 10 years with a follow-up of all participants every three years. To detect individuals who develop dysglycemia during the study, a glucose tolerance test (GTT) and HbA1c measurement will be conducted.

Official Title
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Descendance Cohort: Follow-up of Subjects With Type 2 Diabetes or at Risk of Type 2 Diabetes Defined by the Existence of the Disease in the Family in Two Successive Generations

Conditions
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Diabetes Mellitus, Type 2

Intervention / Treatment
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* Diagnostic Test: OGTT
* Other: HbA1c
* Other: Questionnaire


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects have participated in the Descendance study Subjets who sign informed consent to participate in the study Exclusion Criteria: Subjects not enrolled in Descendance study Subjects refusing to participate Pregnant or breastfeeding Subjects in emergency situations, under legal protection or unable to provide informed -consent Subjects lost to follow-up or died

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| T2D group<br>subjects with type 2 diabetes | Other: Questionnaire<br>* Follow-up questionnaire<br>|
| Non-T2D group<br>healthy subjects | Diagnostic Test: OGTT<br>* Oral Glucose Tolerance Test<br>Other: HbA1c<br>* HbA1c measurement<br>Other: Questionnaire<br>* Follow-up questionnaire<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Type 2 diabetes incidence in Descendance population | Presence of type 2 diabetes mellitus, on basis of self-reported (physician diagnosis) or diagnosed by OGTT and HbA1c | 9years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Provide estimates of prevalence of diabetes and prediabetes in Descendance population | To estimate the prevalence of undiagnosed diabetes mellitus and pre-diabetes in Descendance population | at baseline, 3-, 6- and 9-years follow-up | 
| Study of interactions between risk factors on type 2 diabetes incidence | Self-administered questionnaire. Descendance specific questionnaire | at baseline, 3-, 6- and 9-years follow-up | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Type 2 diabetes ; Risk Prediction ; Prevention