Localizing the Epileptogenic Zone With High Resolution Electroencephalography

Study Overview
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Brief Summary
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Multicenter prospective study comparing the diagnosis value of high-resolution EEG and depth-EEG to localize the epileptogenic zone in drug resistant partial epilepsies.

Official Title
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Etude de la Performance Diagnostique de l'EEG-Haute Résolution Sur la Localisation de la Zone épileptogène Pour le Traitement Chirurgical Des épilepsies Partielles Pharmaco-résistantes

Conditions
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Partial Epilepsy

Intervention / Treatment
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* Device: High Resolution EEG
* Device: Stereo-electroencephalography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: medically intractable patial epilepsy confirmed by video-EEG recordings of epileptic seizures. Depth EEG (Stereo-EEG) required to delineate the epileptogenic zone and define the surgical procedure. full informed consent of the patient (or of his/ her legal representative) 15 year or older patient Exclusion Criteria: contraindication to cortectomy contraindication to depth-EEG indication of epilepsy surgery without depth-EEG monitoring high grade glioma, arterio-veinous malformations pregnancy history of severe cardio-vascular event (coronaropathy, stroke)

Ages Eligible for Study
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Minimum Age: 15 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: high resolution EEG<br> | Device: High Resolution EEG<br>* High Resolution EEG<br>* Other names: electrical source imaging;|
| Active Comparator: Stereo Electroencephalography<br> | Device: Stereo-electroencephalography<br>* SEEG<br>* Other names: depth-electroencephalography;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sensitivity and specificity of electrical source localization of inter-ictal and ictal discharges using high-Resolution EEG for localizing the epileptogenic zone (the stereo-electroencephalography will be the reference method) | results of electrical sources localization of inter-ictal and ictal discharges are compared to the epileptogenic zone defined by SEEG | 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| inter-observer reliability of electrical source localization of inter-ictal and ictal discharges for localizing the epileptogenic zone. | sources localization of inter-ictal and ictal discharges will be interpreted by two independant epileptologists, blinded to the results of stereo-EEG. | 3 years | 
| sensitivity and specificity of high resolution EEG and electrical source imaging for surgical decision | decision of surgery and the limits of the cortectomy established with electrical source imaging will be compared to the decision of surgery and the limits of the cortectomy established with Stereo-electroencephalography. | 3 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Diagnosis, Partial Epilepsy