Cardiovascular Assessment in Patient Recovered From COVID-19 and Recovery of Autonomic Nervous System in Association With the Severity of the Disease

Study Overview
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Brief Summary
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The goal of the study is to assess autonomic nervous system and cardiovascular controll during orthostatic challenge in 90 patients recovered from COVID-19 and devided into three groups depend on severity of the morbidity.

Official Title
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Cardiovascular Assessment in Patient Recovered From COVID-19 and Recovery of Autonomic Nervous System in Association With the Severity of the Disease

Conditions
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COVID-19

Intervention / Treatment
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* Other: Non invasive cardiovascular monitoring with CNAP device of arterial pressure, ECG and respiratory activity


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age over 18 spontaneous sinus rhythm signed informed consent Exclusion Criteria: no spontaneous sinus rhythm pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: COVID-severe<br>patient recovered from severe COVID desease | Other: Non invasive cardiovascular monitoring with CNAP device of arterial pressure, ECG and respiratory activity<br>* Non invasive cardiovascular monitoring with CNAP device of arterial pressure, ECG and respiratory activity during ten minutes in rest and ten minutes in orthostatic position<br>|
| Other: COVID-moderate<br>patient recovered from moderate COVID desease | Other: Non invasive cardiovascular monitoring with CNAP device of arterial pressure, ECG and respiratory activity<br>* Non invasive cardiovascular monitoring with CNAP device of arterial pressure, ECG and respiratory activity during ten minutes in rest and ten minutes in orthostatic position<br>|
| Other: COVID-mild<br>patient recovered from mild COVID desease | Other: Non invasive cardiovascular monitoring with CNAP device of arterial pressure, ECG and respiratory activity<br>* Non invasive cardiovascular monitoring with CNAP device of arterial pressure, ECG and respiratory activity during ten minutes in rest and ten minutes in orthostatic position<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Arterial pressure measured in mmHg | Continuous measurement of the arterial pressure for 10 minutes in rest and 10 minutes in orthostatic position. | 6 months | 
| Heart rate measured in bpm | Continuous measurement of heart rate for 10 minutes in rest and 10 minutes in orthostatic position. | 6 months | 
| Respiratory frequency | Continuous measurement of respiratory frequency for 10 minutes in rest and 10 minutes in orthostatic position. | 6 months |