Sleep, Autonomic Nervous System and Cardiorespiratory Capacity in Autism Spectrum Disorders Children (APAUTRES)

Study Overview
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Brief Summary
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Autism Spectrum Disorders (ASD) is a neurodevelopmental disorder which involves social and behavioural impairments. Autonomic dysfunctions and disturbed sleep were often associated to ASD. The investigators proposed to explore the impact of physical activity on these disorders. In this context, it is necessary to characterize the cardiorespiratory capacities of ASD children in order to promote physical activity for this population. To examine potential differences between ASD and control children, some explorations were proposed: a maximal treadmill test, motor evaluation, and orthostatic test (for the evaluation of autonomic nervous system). An actimetry during one week (evaluation of physical activity and sleep) completed this study in order to specify sleep characteristic and established the possible link between physical activity sleep characteristics and physical fitness in ASD children.

Official Title
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Sleep, Autonomic Nervous System and Cardiorespiratory Capacity in Autism Spectrum Disorders Children

Conditions
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Autonomic Nervous System Diseases, Sleep

Intervention / Treatment
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* Other: physiological explorations


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: children physically active children with an intellectual quotient >70 for autism children a diagnosis of autism in accordance to DSMV Exclusion Criteria: history of cardio-vascular disease history of asthma or respiratory disease Behavior disorders. medical treatment by neuroleptic or melatonin or antiepileptic

Ages Eligible for Study
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Minimum Age: 8 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patients<br>Children from 8 to 18 years with autism without without intellectual disabilities (IQ > 70), verbals and responding to classification CIM 10-DSM IV. | Other: physiological explorations<br> <br> |
| Experimental: Healthy volunteers<br>Paired for age, gender, IQ and and the practice of a physical activity strictly within the school context. | Other: physiological explorations<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cardiorespiratory evaluation | a maximal treadmill test is proposed (evaluation of : VO² max, maximal heart rate) | 1 day | 
| autonomic nervous system evaluation | an orthostatic test is proposed in order to verify the ANS adaptation. A nocturnal recording is made during three nights in order to verify the possible link between the rest autonomic adaptations and a possible dysautonomia observed with the orthostatic test. | 1 day and 3 nights | 
| sleep evaluation | Sleep characteristics are obtained by an actimetry during 7 nights in order to observe sleep disorders. Sleep Questionnaires are also completed. | 7 nights | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| physical activity | physical activity characteristics (sedentary, moderate or vigorous activities, energy expenditure) are obtained by an actimetry during 7 days. Questionnaires of physical activity are also completed | 7 days | 
| Motor capacities | motor capacities are evaluated by several specific tests : PANESS, M-ABS and Eurofit. | 1 day | 
| Behavioural characteristics | Behavioural characteristics are evaluated by the Vineland scale | 1 hour | 
| biological parameters | during the maximal treadmill test, salivary samples are made (cortisol, alpha amylase), before and after tthe test | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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autism spectrum disorder