Serum Inflammatory Marker in Patients With Diagnosis of Nontuberculous Mycobacterial Pulmonary Infection

Study Overview
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Brief Summary
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This study is for those who had nontuberculous mycobacterial pulmonary infection with higher a serum inflammatory marker than those who had colonization.

Detailed Description
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Nontuberculous mycobacteria (NTM), not like Mycobacterium tuberculosis, is ubiquitous in environment including soil and water. Therefore, NTM pulmonary infection is not diagnosed only by microbiology of respiratory specimen but also clinical and radiographical findings.(1) Due to airway NTM colonization is not uncommon in sputum, diagnosis of pulmonary NTM infection is a big challenge in clinical practice. Especially NTM burden is increasing in recent literature.(2,3) Besides, the short-term mortality is reported higher in patients with NTM infection in medical ICU by Shu et al.(4) Early diagnosis and then treatment of NTM infection become important though NTM infection is considered as indolent process before.(1) Inflammatory marker in the patients with NTM being isolated from respiratory specimens is an indicator for differentiating true infection from colonization.(5,6) Those inflammatory factors might include blood white count, C-reactive protein, cytokines, procalcitonin , trigger receptor expressed on myeloid cell-1 (TREM-1) and Toll-like receptor-2. We therefore conduct this prospective study for analyzing

Official Title
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Serum Inflammatory Marker in Patients With Diagnosis of Nontuberculous Mycobacterial Pulmonary Infection

Conditions
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Nontuberculous Mycobacterial Pulmonary Infection

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: more than 18 years study group : Satisfied the criteria for NTM pulmonary disease according to the ATS diagnosis guidelines. control groups: they had positive sputum culture for NTM but not fulfilled the diagnosis criteria Exclusion Criteria: Those with bleeding tendency No inform consent Female with pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with confirmed diagnosis of NTM pulmonary disease<br>Those with sputum mycobacterial culture yielded the same NTM species for at least two sets within one year. | |
| Patients with not definite NTM pulmonary disease<br>Those who had sputum culture yielded NTM but did not satisfy the criteria for diagnosis with NTM pulmonary disease. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnosis of NTM pulmonary disease according to the ATS guidelines |  | 2 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mortality |  | 2 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Make sure the difference of the serum inflammatory marker between the two groups