Stop Ovarian Cancer Young; Effect of the Opportunistic Salpingectomy on Age of Menopause

Study Overview
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Brief Summary
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The aim of this study is to evaluate the long-term safety of on the onset of menopause.

Detailed Description
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The aim of this study is to evaluate the long-term safety of on the onset of menopause. To investigate the effect of Opportunistic Salpingectomy on the age of menopause, we will compare age of menopause in women who underwent sterilization through opportunistic salpingectomy with a control group consisting of women who underwent sterilization by tubal ligation or who had no sterilization.

Official Title
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Stop Ovarian Cancer Young; Effect of the Opportunistic Salpingectomy on Age of Menopause

Conditions
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Salpingectomy, Tubal Ligation, Menopause

Intervention / Treatment
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* Procedure: Opportunistic salpingectomy / bilateral salpingectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Intervention group Undergoing an Opportunistic Salpingectomy as sterilization method Premenopausal status at enrolment Age between 30 and 45 years Will have residual ovarian tissue after surgery Able to understand the written or spoken Dutch language Gives consent for participating in surveys Control group Premenopausal status at enrolment Either sterilization by tubal ligation or no sterilization at all Age between 35 and 45 years Able to understand the written or spoken Dutch language Gives consent for participating in surveys Exclusion Criteria: Postmenopausal status at enrolment Under the age of 35 or above 45 Previous salpingectomy of oophorectomy Previous hysterectomy Women with abnormal karyotype (such as Turner Syndrome and Fragile X syndrome) Underwent chemotherapy or radiation Unable to understand the written or spoken Dutch language

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Intervention: bilateral salpingectomy<br>Premenopausal women between 30 and 45 years of age, who will undergo sterilization through Opportunistic Salpingectomy will be asked to participate in the STOPOVCAyoung study. | Procedure: Opportunistic salpingectomy / bilateral salpingectomy<br>* An opportunistic salpingectomy refers to removal of the salpinges without the ovaries during (laparoscopic) interventions for benign (gynaecological) disease to reduce the number of ovarian cancer cases. Therefore, a so-called opportunistic salpingectomy is a method of female sterilization.<br>|
| Control: tubal ligation or no sterilization<br>The control group will consists of women who chose for sterilization by clips/tubal ligation supplemented by friend/acquaintances, around the same age, who are not planning to undergo sterilization. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Menopausal age | The age of reaching natural menopause (e.g. last menstruation > 1 year ago ) | At end of follow-up (follow up ends at age of menopause with a maximum follow-up time of 15 years) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Decision regret | The decision regret regarding their choice of sterilization method. | 1 year post surgery and at age of menopause | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Salpingectomy, Sterilization, Tubal ligation, Opportunistic salpingectomy, Menopausal age