Determination of the Predictive Factors in the Reversibility or the Aggravation in the Disorders of the Glucose Metabolism in Cystic Fibrosis Patients

Study Overview
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Brief Summary
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For some years, the investigators observe an increase of the arisen of diabetes in cystic fibrosis patients However, this diabetes may be reversible. The investigators speak about  Cystic fibrosis related diabetes.. The objective of this project, is to know better what facilitates the appearance and the reversibility of the diabetes, such as the genetic mutations, the respiratory state and the lung infections. Theses knowledges should allow to adapt the screening of diabetes, and its treatment, for the patients affected by cystic fibrosis.

Official Title
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Determination of the Predictive Factors in the Reversibility or the Aggravation in the Disorders of the Glucose Metabolism in Cystic Fibrosis Patients (Study DIAMUCO)

Conditions
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Diabetes in Cystic Fibrosis Patients

Intervention / Treatment
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* Other: Prospective cohort with an annual follow-up


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Cystic fibrosis patients with at least one visit in Cystic fibrosis Center in Rhône-Alpes (France) during the second half-year 2008 Patients with disorders or not of the glucose metabolism Patient with pancreatic insufficiency Exclusion Criteria: Patient with hypoglycemia treatment : insulin or oral antidiabetic Patient with an age < 10 years Patient with lung transplant

Ages Eligible for Study
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Minimum Age: 10 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Prospective cohort with an annual follow-up|Annualfollow-up including : oral glucose tolerance test dietary survey biological evaluation bacteriological and respiratory measures dual-energy x-ray absorptiometry physical activity survey|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Describe the natural history of the glucose tolerance in cystic fibrosis patients and to identify the predictive factors of the reversibility or the aggravation in the disorders of the glucidic metabolism. |  | 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Estimate prevalence of the various stages of disorders of the glucose metabolism : glucose intolerance and diabetes |  | 3 years | 
| Estimate the probability of arisen the complications associated to the disorders of the glucidic metabolism : - deterioration of the respiratory function, - lung exacerbations - alteration of the nutritional state |  | 3 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cystic fibrosis -diabetes - glucose tolerance - reversibility - oral glucose tolerance test - predictive factors