A Study to Compare Health Care Costs Between Apixaban and Low Molecular Weight Heparin in Patients With Venous Thromboembolism and Cancer

Study Overview
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Brief Summary
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The purpose of this study is to evaluate the health care resource utilization and costs associated with treating patients diagnosed with cancer and venous thromboembolism with apixaban or low molecular weight heparin. This is a retrospective database analysis of health care claims data. All-cause costs as well as costs associated with recurrent VTE, major bleeding, and clinically relevant nonmajor bleeding will be assessed.

Official Title
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Cost Comparison Between Apixaban and Low Molecular Weight Heparin (LMWH) Among Venous Thromboembolism (VTE) Cancer Patients

Conditions
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Thromboembolism

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Venous thromboembolism (VTE) diagnosis between January 1 2017 and October 31 2021 Evidence of active cancer At least 1 claim for apixaban or low molecular weight heparin (LMWH) Age 18 years or older Exclusion Criteria: diagnosis of atrial fibrillation/flutter procedure for mechanical heart valve or inferior vena cava filter VTE diagnosis in the baseline period anticoagulant therapy in the baseline period pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| apixaban<br>patients treated with apixaban | |
| Low molecular weight heparin (LMWH)<br>patients treated with low molecular weight heparin | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total all-cause Healthcare Costs: Total Healthcare Costs Per Person Per Month (PPPM) |  | from index date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| All-cause Healthcare Costs: Outpatient Pharmacy Costs Per Person Per Month |  | from index date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| All-cause Healthcare Costs: Outpatient Medical Costs Per Person Per Month |  | from index date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| All-cause Healthcare Costs: Hospitalization Costs Per Person Per Month |  | from index date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| Recurrent Venous Thromboembolism (VTE) related Costs: Total costs Per Person Per Month |  | from event date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| Recurrent VTE related costs: Outpatient Medical Costs Per Person Per Month |  | from event date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| Recurrent VTE related Costs: Hospitalization Costs Per Person Per Month |  | from event date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| Major Bleeding Related Costs: Total Costs Per Person Per Month |  | from event date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| Major Bleeding Related Costs: Outpatient Medical Costs Per Person Per Month |  | from event date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| Major Bleeding Related Costs: Hospitalization Costs Per Person Per Month |  | from event date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| Clinically Relevant Non-Major Bleeding Related Costs: Total Costs Per Person Per Month |  | from event date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| Clinically relevant Non-Major Bleed Related Costs: Outpatient Medical Costs Per Person Per Month |  | from event date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| Clinically Relevant Non-Major Bleeding Related Costs: Hospitalization Costs Per Person Per Month |  | from event date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| All-cause Health Care Resource Utilization: Number of Hospitalizations Per Person Per Month |  | from index date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| All-cause Health Care Resource Utilization: Number of Emergency Room Visits Per Person Per Month |  | from index date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| All-cause Health Care Resource Utilization: Number of Outpatient Medical Visits Per Person Per Month |  | from index date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| All-cause Health Care Resource utilization: Number of Prescription Fills Per Person Per Month |  | from index date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| Recurrent Venous Thromboembolism (VTE) Related Health Care Resource Utilization: Number of Hospitalizations Per Person Per Month |  | from event date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| Recurrent VTE Related Health Care Resource Utilization: Number of Outpatient Medical Visits Per Person Per Month |  | from event date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| Recurrent VTE Related Health Care Resource Utilization: Number of Emergency Room Visits Per Patient Per Month |  | from event date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| Major Bleeding Related Health Care Resource Utilization: Number of Hospitalizations Per Person Per Month |  | from event date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| Major Bleeding Related Health Care Resource Utilization: Number of Outpatient Medical Visits Per Person Per Month |  | from event date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| Major Bleeding Related Health Care Resource Utilization: Number of Emergency Room Visits Per Person Per Month |  | from event date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| Clinically Relevant Non-Major Bleeding Related Health Care Resource Utilization: Number of Hospitalizations Per Person Per Month |  | from event date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| Clinically Relevant Non-Major Bleeding Related Health Care Resource Utilization: Number of Outpatient Medical Visits Per Person Per Month |  | from event date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months | 
| Clinically Relevant Non-Major Bleeding Health Care Resource Utilization: Number of Emergency Room Visits Per Person Per Month |  | from event date up to the earliest of health plan disenrollment, treatment discontinuation or switch, or end of study period. Assessed up to 60 months |