Clinical Registration Study of Patients With Intracranial / Carotid Stenosis

Study Overview
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Brief Summary
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Through prospective registration and follow-up, this study will collect data of patients with intracranial/carotid stenosis, including clinical information, neuropsychological scales, multimodal magnetic resonance images. The investigators aim to analyze clinical and imaging characteristics of patients with cognitive impairment related to intracranial/carotid stenosis, in order to achieve early identification of cognitive impairment.

Official Title
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Clinical Registration Study of Patients With Intracranial / Carotid Stenosis

Conditions
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Stenosis, Cognitive Function

Intervention / Treatment
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* Drug: standard medical treatment
* Procedure: Interventional stenting


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged ≥ 40 years ≥ 50% stenosis in unilateral intracranial / carotid artery Written informed consent available Exclusion Criteria: Previous history of major head trauma and any intracranial surgery Intracranial abnormalities, such as intracerebral hemorrhage, subarachnoid hemorrhage and other space occupying lesions Extrapyramidal symptoms or mental illness which may affect neuropsychological measurement Severe loss of vision, hearing, or communicative ability Exit Criteria: Not meet the inclusion criteria For any poor adherence, not comply with the requirements of the follow-up, or safety reasons determined by investigator Any adverse or serious adverse events during the study period judged by investigator

Ages Eligible for Study
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Minimum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: standard medical treatment|standard medical treatment|
|Procedure: Interventional stenting|Interventional stenting|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in the scores of Mini-mental State Examination | Total score of 30. Higher scores mean a better outcome. | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of stroke event including ischemic and hemorrhagic stroke |  | 2 years | 
| Changes in cerebral glymphatic function | assessed by non-invasive diffusion tensor image analysis along the perivascular space (ALPS-index) | 2 years | 
| Changes in the scores of Montreal Cognitive Assessment | Total score of 30 | 2 years | 
| Changes in cerebral blood flow in the territory of the culprit artery |  | 2 years | 
| Changes in the scores of Colour Trail Test |  | 2 years | 
| Changes in the scores of Hopkins Verbal Learning Test |  | 2 years | 
| Changes in the scores of clock drawing test |  | 2 years | 
| Changes in the scores of Animal Fluency Test |  | 2 years | 
| Changes in the scores of Olfactory stick test |  | 2 years | 
| Changes in metabonomics | include blood and fecal samples | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cognitive Function, Intracranial / Carotid Stenosis