Effects of Aerobic Training in End Stage Renal Disease Patients

Study Overview
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Brief Summary
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The investigators raised the hypothesis that exercise training would be associated with improvement in exercise tolerance and VO2 kinetics in hemodialysis patients.

Detailed Description
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End-stage renal disease (ESRD) is associated with several hemodynamic and peripheral muscle abnormalities which could slow the kinetics of O2 uptake(VO2)and diminished tolerance to incremental exercise. Although previous studies have shown that aerobic training is able to accelerate VO2 kinetics in several disease populations, little is known if these positive findings are also applicable to hemodialysis patients.

Official Title
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Effects of Aerobic Training During Hemodialysis on Exercise Tolerance in End Stage Renal Disease Patients

Conditions
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Kidney Failure, Chronic

Intervention / Treatment
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* Other: Exercise training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The sample included end stage renal disease patients undergoing hemodialysis, three times per week totaling 12h weekly, for at least 6 months in the Nephrology Unit at the University Hospital of the Federal University of Juiz de Fora, State of Minas Gerais, Brazil. No patient had been involved in any kind of exercise training in the preceding 6 months Exclusion Criteria: unstable angina; uncontrolled arrhythmia; uncompensated heart failure; uncontrolled hypertension (systolic blood pressure ≥ 200 mmHg and/or diastolic blood pressure ≥ 120 mmHg); diabetes mellitus; severe respiratory diseases; acute infection; severe renal osteodystrophy; neurological or musculoskeletal disturbances

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Exercise training<br>Patients included in the exercise group were submitted to intra-dialytic exercise training, 3 times per week for 12 weeks. | Other: Exercise training<br>* Patients included in the exercise group were submitted to intra-dialytic exercise training, 3 times per week for 12 weeks.<br>* Other names: Exercise group;|
| No Intervention: Control<br>Patients allocated to the control group remained in regular dialysis treatment during the same timeframe. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effects of aerobic training during hemodialysis on exercise tolerance and VO2 kinetics in end stage renal disease patients | Before and after the intervention or control periods, the participants were submitted to an incremental work rate test and, two days apart, to a constant work rate test to the limit of tolerance. | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Exercise Tolerance, Physical Endurance