Establishment of a Tumor Bank for Tissue Samples

Study Overview
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Brief Summary
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Establishment of a tumor bank, consisting of tissue samples of tumor patients (benign and malign tumors) and healthy people as controls. The tissue samples will be collected systematically together with the corresponding clinical data. The biological samples, the clinical date together with prospective experimental date constitute the entity of the tissue tumor bank. This tumor bank for tissue samples, together with our tumorbank for blood samples (NCT01763125) combined constitute the entity Tumorbank.

Detailed Description
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Recent progress in diagnosis and therapy of cancer diseases can be ascribed mainly to translational research. The relevance of translational oncology will only increase in the future -From bench to bedside - the swift implementation of new science research results in clinical studies in order to expedite progress in clinical cancer therapy for the benefit of the patient. Its almost a matter of course in the medical science today to collect biological samples together with clinical information thereby creating the foundation for future excellent fundamental research. The aim of this tumor bank is to consist of biological samples (together with a blood bank - see NCT01763125) and isolates of tumor patients and healthy people as controls. The biological samples, the clinical date together with prospective experimental date constitute the entity of the tumor bank. The content of the tumor bank can provide essential material for current and future research (e.g. analyses of prognostic or predictive tumor markers; genetically analysis (polymorphism, mutation, hypermethylation; verification and characterisation of disseminated tumor cells).

Official Title
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Establishment of a Tissue Sample Bank in the Field of Gynaecological Oncology

Conditions
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Ovarian Neoplasms, Breast Neoplasms, Colorectal Neoplasms, Neoplasms of the Female Genitalia, Lung Neoplasms, Endocrine Gland Neoplasms

Intervention / Treatment
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* Other: Tumor tissue collection
* Other: Sampling of ascites and pleural effusion
* Other: Collecting urine samples
* Other: Collecting saliva sample
* Other: Collecting sputum
* Other: Collecting stool samples
* Other: Lavage/Irrigation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male/Female Age 18 to 90 years max. Just one current known malignant disease or just one current inflammatory disease Exclusion Criteria: Inflammatory disease and malignant disease multiple malignancies multiple diseases underage

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Malignant tumors<br>Patients who have one of the Neoplasms stated above under conditions. | Other: Tumor tissue collection<br>* Tissue sample is collected during therapeutic intervention by a medical doctor/surgeon. Frozen tissue sections are first transferred to Dept.of Pathology. Pathologist samples required tissue to obtain enough evidence for analysis/diagnosis. Rest tumor material with or without malignant cells is tranferred to the lab for Molecular Oncology of Prof.Zeillinger.<br>Other: Sampling of ascites and pleural effusion<br>* Samples of malignant ascites and/or malignant pleural effusion is only collected during therapeutic intervention from patients at inpatient care.<br>Other: Collecting urine samples<br>* Patient is asked to give a urine sample. Urine is collected in urine beaker.<br>Other: Collecting saliva sample<br>* Saliva sample is collected by spatula from the mouth cavity of the patient.<br>Other: Collecting sputum<br>* Patient is asked to produce sputum into a 50ml lab tube.<br>Other: Collecting stool samples<br>* Stool samples are collected prior to bowel preparation for colonoscopy. Device for sampling is provided to the patient.<br>Other: Lavage/Irrigation<br>* Irrigation liquid is collected during routine therapeutic or diagnostic procedure, e.g. lavage of the uterine cavity and fallopian tubes of women scheduled for surgery.<br>|
| Benign controls<br>Patients with a benign tumor or an inflammatory disease - to be matched by age. | Other: Tumor tissue collection<br>* Tissue sample is collected during therapeutic intervention by a medical doctor/surgeon. Frozen tissue sections are first transferred to Dept.of Pathology. Pathologist samples required tissue to obtain enough evidence for analysis/diagnosis. Rest tumor material with or without malignant cells is tranferred to the lab for Molecular Oncology of Prof.Zeillinger.<br>Other: Sampling of ascites and pleural effusion<br>* Samples of malignant ascites and/or malignant pleural effusion is only collected during therapeutic intervention from patients at inpatient care.<br>Other: Collecting urine samples<br>* Patient is asked to give a urine sample. Urine is collected in urine beaker.<br>Other: Collecting saliva sample<br>* Saliva sample is collected by spatula from the mouth cavity of the patient.<br>Other: Collecting sputum<br>* Patient is asked to produce sputum into a 50ml lab tube.<br>Other: Collecting stool samples<br>* Stool samples are collected prior to bowel preparation for colonoscopy. Device for sampling is provided to the patient.<br>Other: Lavage/Irrigation<br>* Irrigation liquid is collected during routine therapeutic or diagnostic procedure, e.g. lavage of the uterine cavity and fallopian tubes of women scheduled for surgery.<br>|
| Healthy controls<br>People/patients who have no known disease at time of sampling or are admitted to the hospital for minor interventions and have no inflammatory disease. | Other: Collecting urine samples<br>* Patient is asked to give a urine sample. Urine is collected in urine beaker.<br>Other: Collecting saliva sample<br>* Saliva sample is collected by spatula from the mouth cavity of the patient.<br>Other: Collecting sputum<br>* Patient is asked to produce sputum into a 50ml lab tube.<br>Other: Collecting stool samples<br>* Stool samples are collected prior to bowel preparation for colonoscopy. Device for sampling is provided to the patient.<br>Other: Lavage/Irrigation<br>* Irrigation liquid is collected during routine therapeutic or diagnostic procedure, e.g. lavage of the uterine cavity and fallopian tubes of women scheduled for surgery.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Establishment of blood/tissue bank consisting of oncological samples from cancer patients and benign and healthy controls. |  | 14 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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biobank, fresh-frozen tissue