MR Spectroscopy as a Diagnostic and Outcome Measure in Pain and SCI

Study Overview
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Brief Summary
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The goal of this study is to compare the changes that occur in sensation and chemical properties of the brain following SCI between individuals that experience chronic pain and those that do not, and between those with SCI and the able-bodied.

Detailed Description
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This study investigates the differences in certain neurochemicals present in areas of the brain linked to pain processing in people with SCI and neuropathic pain, in people with SCI but no pain, and in able-bodied persons. We will also investigate the relationship between these concentrations of neurochemicals and different aspects of chronic neuropathic pain, including the intensity of pain, quality of life issues, sensitivity changes in areas of the body that are both painful and non-painful, and neurological status.

Official Title
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MR Spectroscopy (MRS) as a Diagnostic and Outcome Measure in Pain and SCI

Conditions
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Spinal Cord Injury, Hyperalgesia, Secondary, Hyperalgesic Sensations

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: SCI and neuropathic pain: fluent in English incomplete or complete traumatic SCI the injury must have occurred at least 2 years prior to entering the study the injury level must be above L1 and the subjects must have evidence of preserved distal cord functions (lower extremity reflexes and bulbocavernosus or anal wink reflexes) must have experienced chronic neuropathic pain at or below the level of injury for a minimum of six months must have moderately severe or greater neuropathic pain must be able to attend three sessions ranging from 2 to 6 hours over a period of 4 to 5 weeks SCI and no neuropathic pain: - same as a., but participants in this group must NOT have unremitting moderate-severe pain and there will only be two sessions ranging from 2 to 6 hours over a period of 1 to 2 weeks Able-bodied control subjects: fluent in English no history of chronic pain conditions no substantial brain or body injury must be able to attend two sessions ranging from 2 to 6 hours over a period of 1 to 2 weeks Exclusion Criteria: current pregnancy or women who are contemplating pregnancy recent (one-year) history of alcohol or drug abuse known intra-cerebral pathology or epilepsy MRI findings indicative of intra-cerebral pathology significant post-traumatic encephalopathy from head trauma sustained at SCI or cognitive impairment indicative of traumatic brain injury current diagnosis of DSM-IV Axis I disorder inability to meet the MRI screening requirements (including, but not limited to, the presence of a pacemaker or other electronic devices, prosthesis, artificial limb or joint, shunt, some metal rods, some tattoos, or moderate to severe claustrophobia or anxiety)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1<br>Spinal cord injured with chronic central neuropathic pain. | |
| Group 2<br>Spinal cord injured without chronic central neuropathic pain. | |
| Group 3<br>Able-bodied without history of chronic pain of any type | |
| Group 4<br>Traumatically Brain Injured with a history of pain that onset after their TBI | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Using MR Spectroscopy to measure the concentration of N-acetyl aspartate, glutamate/glutamine, and myo-inositol in the areas of the brain thought to process pain. |  | Two measures at intervals of 2 to 4 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Spinal Cord Injury Pain, Chronic Neuropathic Pain, SCI Pain, Pain, Chronic Neuropathic, Spectroscopy, Magnetic Resonance, MRS, Traumatic Brain Injury Pain