A Study of ABT-263 in Combination With Dose-Intensive Rituximab, or Dose-Intensive Rituximab Alone, in Previously Untreated Patients With B-Cell, Chronic Lymphocytic Leukemia (CLL)

Study Overview
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Brief Summary
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This Phase II, randomized, open-label, international, multicenter trial is designed to evaluate the safety and efficacy of rituximab monotherapy when given according to a dose intense regimen and to assess the safety, efficacy, and pharmacokinetics of ABT-263 when combined with dose-intense rituximab in previously untreated patients with B-cell CLL.

Official Title
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A Phase II, Multicenter, Randomized, Controlled, Open-label Study of the Safety, Efficacy and Pharmacokinetics of ABT-263 in Combination With Dose-intensive Rituximab, or Dose-intensive Rituximab Alone, in Previously Untreated Patients With B-Cell, Chronic Lymphocytic Leukemia (CLL)

Conditions
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Chronic Lymphocytic Leukemia

Intervention / Treatment
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* Drug: ABT-263
* Drug: rituximab


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Previously untreated, CD20-positive B-cell CLL ECOG performance status of 0 or 1 Life expectancy > 6 months Willingness and capability to be accessible for follow-up until study termination or death For patients of reproductive potential (both males and females), use of a reliable means of contraception Exclusion Criteria: Prolymphocytic leukemia Richter's transformation to an aggressive B-cell malignancy (e.g., DLBCL) Prior radiotherapy to a lesion(s) that will be used to assess response unless that lesion(s) shows clear evidence of progression at baseline Patients with a history of other malignancies within 2 years prior to study entry except for adequately treated carcinoma in situ of the cervix, basal or squamous cell skin carcinoma, low-grade, localized prostate cancer treated surgically with curative intent or one that carries a good prognosis, in situ ductal carcinoma of the breast treated with lumpectomy alone with curative intent Prior treatment with rituximab, ABT-263 or other pro-apoptotic agents Current or recent (within the 28 days prior to initiation of study treatment) participation in another experimental drug study Major surgical procedure (excluding lymph node biopsy) or significant traumatic injury within 28 days prior to treatment onset or anticipation of the need for major surgery during the course of the study Active infection requiring parenteral antibiotics or antiviral or antifungal agents at the onset of study treatment Receipt of primary or booster vaccination with live-virus vaccines for up to 6 months prior to initiation of study treatment Patients receiving therapeutic anticoagulation with heparin or warfarin or patients receiving any drugs or herbal supplements that are known to inhibit platelet function (including low-dose aspirin) within 7 days of the first dose of ABT-263. Note: Patients receiving low-dose anticoagulation for the purpose of maintaining central venous catheter patency are eligible. Patients who have an inherited or acquired bleeding diathesis, including (but not limited to) hemophilia or immune or thrombotic thrombocytopenic purpura, or who have had an underlying condition that predisposes to abnormal bleeding (e.g., peptic ulcer disease) within 1 year prior to the first dose of ABT-263 Patients with a history of refractoriness to platelet transfusions Clinically significant cardiovascular disease Known human immunodeficiency virus (HIV) infection, seropositivity for hepatitis B surface antigen (HBsAg) or hepatitis C virus (HCV) antibody or RNA Pregnancy or breastfeeding Concurrent (or within 7 days prior to the first dose of study treatment) systemic corticosteroid therapy except some low-dose corticosteroid therapies History of other disease, metabolic dysfunction, physical or laboratory finding(s) giving reasonable suspicion of a disease or condition that contraindicates use of an investigational drug, might affect interpretation of the results of the study or render the patient at high risk from treatment complications History of anaphylaxis, allergic reaction, or hypersensitivity to sulfites (sodium metabisulphite is included in study drug formulation) Any contraindication to alcohol ingestion (study drug formulation includes approximately 15% ethanol)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: A<br> | Drug: rituximab<br>* Intravenous repeating dose<br>|
| Experimental: B<br> | Drug: ABT-263<br>* Oral repeating dose<br>Drug: rituximab<br>* Intravenous repeating dose<br>|
| Experimental: C<br> | Drug: ABT-263<br>* Oral repeating dose<br>Drug: rituximab<br>* Intravenous repeating dose<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression-free survival |  | From randomization to the first occurrence of progression, relapse, or death on study (approximately 40 months from First Patient In [FPI]) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall response rate (ORR) |  | Approximately 40 months from FPI | 
| Duration of response |  | Approximately 40 months from FPI | 
| Complete response (CR) rate |  | Approximately 40 months from FPI | 
| Progression-free survival as assessed by a blinded, independent review |  | From randomization to the first occurrence of progression, relapse, or death on study (approximately 40 months from FPI) | 
| ORR as assessed by a blinded, independent review |  | Approximately 40 months from FPI | 
| Duration of response as assessed by a blinded, independent review |  | Approximately 40 months from FPI | 
| CR rate as assessed by a blinded, independent review |  | Approximately 40 months from FPI | 
| Overall survival (OS) |  | From randomization until death due to any cause (approximately 4 years after Last Patient In) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Rituxan, Apoptosis, BCl-2