Quality of Life Assessment of Chronic Pancreatitis Endoscopic Interventions

Study Overview
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Brief Summary
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This study seeks to evaluate the effect of endoscopic interventions on quality of life in patients with chronic pancreatitis. Quality of life will be evaluated using the PANQOLI, a validated quality of life instrument specific to chronic pancreatitis. Endoscopic interventions will include pancreatic duct dilation and stenting, celiac plexus block, lithotripsy and removal of pancreatic duct stones, and pseudocyst drainage.

Detailed Description
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This is a multicenter prospective cohort study assessing the impact of endoscopic interventions on patients with chronic pancreatitis. Patients with chronic pancreatitis referred for endoscopic treatment, including pancreatic duct dilation and stenting, pseudocyst drainage, celiac plexus blocks, and pseudocyst drainage/necrosectomy will be enrolled in this study. They will receive a baseline evaluation using the PANQOLI, a chronic pancreatitis-specific quality of life instrument, in addition to a visual analog scale to measure their pain. Demographic and endoscopic features will be collected in addition to pain medication use. Patients will receive follow-up at 1, 3, and 6 months post-intervention consisting of the PANQOLI, visual analog scale for pain, and pain medication use.

Official Title
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Quality of Life Evaluation of Endoscopic Interventions in Chronic Pancreatitis

Conditions
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Chronic Pancreatitis

Intervention / Treatment
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* Other: PANQOLI (quality of life instrument)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with painful chronic pancreatitis, defined as either 1) the presence of pancreatic calcifications on cross-sectional imaging, 2) morphologic changes consistent with the Rosemont criteria on endoscopic ultrasound, or 3) endoscopic pancreatic function test results consistent with decreased pancreatic function. Exclusion Criteria: Pregnant females Prisoners Patients under the age of 18 Patients lacking the capacity to consent

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: PANQOLI (quality of life instrument)|A quality of life instrument, the PANQOLI, will be administered prior to endoscopic intervention, and at 1,3, and 6 months post-intervention.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Quality of Life using the PANQOLI (PANcreatitis Quality of Life Instrument) | The primary outcome will be the change in quality of life using the PANQOLI (PANcreatitis Quality of Life Instrument) after endoscopic intervention. | The outcome will be measured at 1, 3, and 6 months post-intervention. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in pain level using the Visual Analog Scale (VAS) for pain. | The secondary outcome will include the change in pain using the Visual Analog Scale (VAS) for pain after endoscopic intervention | The outcome will be measured at 1, 3, and 6 months post-intervention. | 
| Change in pain medication use | The secondary outcome will include the change in pain medication use after endoscopic intervention. | The outcome will be measured at 1, 3, and 6 months post-intervention. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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chronic pancreatitis, quality of life