In Vivo and ex Vivo Validation of MR Tractography of Brain White Matter Tracts - FIBRATLAS II-III

Study Overview
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Brief Summary
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White matter tracts connect cortical areas to other parts of the cortex, to basal ganglia and to the brain stem and spinal cord. These tracts form the internal part of the brain and transmit the nervous impulses. Changes in brain white matter may serve as biomarkers for numerous neurological diseases. Diffusion Weighted Imaging (DWI) is a non-invasive MRI (Magnetic Resonance Imaging) technique providing information on white matter tracts (tractography) by studying water diffusion. Since it is based on complex mathematical models that only indirectly evaluates the underlying anatomy, tractography need to be validated before being used for research and clinical purposes. Several validation techniques were previously proposed, none of them being fully convincing in human.

Official Title
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In Vivo and ex Vivo Validation of MR Tractography of Brain White Matter Tracts - FIBRATLAS II-III

Conditions
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Neurological Diseases

Intervention / Treatment
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* Device: MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Prior enrollment in a body donation program Age ≥ 82 years Absence of major cognitive impairment as demonstrated by independent living skills in 4 fields evaluated by the IADL (4 items) (Lawton and Brody, 1969) Distance to one of the participating laboratories ≤ 120km Able to remain supine in the MR scanner for acquisition duration (60 min), Affiliation to Social Security Informed and written consent Non Inclusion Criteria: Past or present Neurological or Neurosurgical diseases (excluding trauma or degenerative spinal lesions) Uncontrolled: High blood pressure, diabetes (types I or II), or dyslipemia Contraindications to MRI Contraindication to body donation Exclusion criteria Diagnosis on MRI of brain lesions, excepted common age-related changes

Ages Eligible for Study
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Minimum Age: 82 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Healthy subjects<br>MRI and neuropsychological evaluation | Device: MRI<br>* In vivo MRI with B0 cartography, FLAIR, 3D T1 anatomic images, DWI, and Tractography from DWI images<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reconstructions of the fiber tracts | similarity indices, such as modified Haussdorf distance, measured on MRI images | 5.5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of subjects included in the database | Number of subjects included in the database | 5.5 years | 
| Scores at neuropsychological evaluation | Scores at neuropsychological evaluation | 5.5 years | 
| In vivo MRI measures obtained from DWI | In vivo MRI measures obtained from DWI | 5.5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Tractography, white, physiology, analysis, matter, tracts, MRI