Effects of Intravenous Anesthesia on Postoperative Cognitive Function in Patients Accepted Painless Gastroenteroscopy

Study Overview
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Brief Summary
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The investigators want to study the effect of intravenous anesthesia on postoperative cognitive function in patients accepted gastroenteroscopy ,no additional medication or operation is involved

Detailed Description
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The investigators want to study the effect of intravenous anesthesia on postoperative cognitive function in patients accepted gastroenteroscopy ,no additional medication or operation is involved.The investigators assess cognitive function through a series of tests for 4 times( within 3 days before the endoscopy ,2 hours after the endoscopy finished,1 week after the endoscopy,3 months after the endoscopy),including WCST、DSST、DST、HADS、MoCA,through self - contrast,the investigators will conclude whether intravenous anesthesia has bad impact on cognitive function or not .

Official Title
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Effects of Intravenous Anesthesia on Postoperative Cognitive Function in Patients Accepted Painless Gastroenteroscopy

Conditions
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Postoperative Cognitive Function

Intervention / Treatment
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* Behavioral: a series of tests


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: voluntary to participate in Vital signs are stable no drug or alcohol abuse no mental illness no severe central system diseases such as brain infarction between 18 and 80 no liver or kidney dysfunction will perform endoscopy for various reasons Exclusion Criteria: illiteracy color blindness can't write or refused to sign informed consent unable to follow up regularly or cooperate with the examination drug or alcohol abuse hearing or visual serious impairment has severe central nervous system diseases such as shoke ,neurosyphilis uncontrolled high blood pressure or hyperglycemia neurosyphilis history of craniotomy for various reasons liver and kidney dysfunction non-digestive tumors history of intravenous or general anesthesia for other causes in the last 3 months

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| A: anesthesia group<br>Patients accepting endoscopy check under anesthesia will be included in this group as group A,will doing a series of tests | Behavioral: a series of tests<br>* all patients in every group will do a series of tests,including DSST、DST、MoCA、WCST、HADS<br>|
| B:Non-anesthesia group<br>patients undergoing endoscopy check without anesthesia will be included in this group as controls voluntarily,namely group B,will doing a series of tests | Behavioral: a series of tests<br>* all patients in every group will do a series of tests,including DSST、DST、MoCA、WCST、HADS<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in patient's cognitive dysfunction evaluated by WCST | The Wisconsin Card Sorting Test (WCST) is a neuropsychological test of set-shifting,.A number of stimulus cards are presented to the participant. The participant is told to match the cards, but not how to match; however, he or she is told whether a particular match is right or wrong. The test takes approximately 12-20 minutes to carry out and generates a number of psychometric scores, including numbers, percentages, and percentiles of: categories achieved, trials, errors, and perseverative errors | 4 months | 
| Change in patient's cognitive dysfunction evaluated by DST | DST(Digit Span Test.),It is used to measure working memory's number storage capacity. Participants see or hear a sequence of numerical digits and are tasked to recall the sequence correctly, with increasingly longer sequences being tested in each trial. The participant's span is the longest number of sequential digits that can accurately be remembered. Digit-span tasks can be given forwards or backwards, meaning that once the sequence is presented, the participant is asked to either recall the sequence in normal or reverse order.Digit-span tasks are the most commonly used test for memory span, partially because performance on a digit-span task cannot be affected by factors such as semantics, frequency of appearance in daily life, complexity, etc. | 4 months | 
| Change in patient's cognitive dysfunction evaluated by DSST | DSST(Digit Symbol Test).,The participants need to write the number referred to each symbol in 90 seconds.Number of hits are registered. The test measures short-term memory, visualspatial skills and attention. | 4 months | 
| Change in patient's cognitive dysfunction evaluated by MoCA | MoCA （Montreal Cognitive Assessment）, The visual spatial executive ability, naming,memory, attention, language fluency, abstract,thinking, delayed memory and directional force are included in the test, a total of 30 points. The subjects whose have less than 12-year of education were added 1 point in the testing result, with correction of bias in the degree of culture. The patients whose get higher scores indicate that the cognitive function is better, 26 points as normal. | 4 months |