Analysis of Health Status of Сomorbid Adult COVID-19 Patients Hospitalised in Second Wave of SARS-CoV-2 Infection

Study Overview
=================
Brief Summary
-----------------
Comparison of COVID-19 disease course in hospitalized patients infected by SARS-CoV-2 in first and second waves of the novel coronavirus infection

Detailed Description
-----------------
Non-commercial depersonalized multi-centered registry study on analysis of chronic non-infectious diseases dynamics after SARS-CoV-2 in first and second waves of the novel coronavirus infection in cohort of Russian adult patients. Retrospective analysis of medical histories and outcomes in adults with pre-existing conditions after SARS-CoV-2 infection. Comorbidities worsening risk factors measuring through evaluation of range of indicators such as dynamics of diabetes, CKD, COPD, bronchial astma, incidence of hypertonic crises, vascular events and others.

Official Title
-----------------
Analysis of Health Status of Сomorbid Adult COVID-19 Patients Hospitalised in Second Wave of SARS-CoV-2 Infection

Conditions
-----------------
DVT, CKD, Covid19, Comorbidities and Coexisting Conditions, Risk Factor, Cardiovascular, Death, Diabetes, COPD, Atrial Fibrillation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Suspected or confirmed COVID-19 (according to results of swab-test, antibody test, computed tomography or radiography image) Exclusion Criteria: Unwillingness to participate in the study; Age under 18.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| death | death for any reason | 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of cases of Acute Kidney Injury depending on Coexisting Conditions | Number of cases of Acute Kidney Injury depending on Coexisting Conditions | 4 weeks | 
| Number of cases of Myocarditis and Acute Coronary Events depending on Coexisting Conditions | Number of cases of Myocarditis and Acute Coronary Events depending on Coexisting Conditions | 4 weeks | 
| Number of cases of Cytokine Storm depending on Coexisting Conditions | Number of cases of Cytokine Storm depending on Coexisting Conditions | 4 weeks | 
| Number of thrombotic and thromboembolic complications of COVID-19 depending on Coexisting Conditions | Number of thrombotic and thromboembolic complications of COVID-19 depending on Coexisting Conditions | 4 weeks | 
| Decline in GFR excluding Acute Kidney Injury by the time of discharge depending on Coexisting Conditions | Decline in GFR excluding Acute Kidney Injury by the time of discharge depending on Coexisting Conditions | 4 weeks | 
| Rate of cases of health status worsening occured during hospitalisation | Rate of cases of health status worsening occured during hospitalisation | 4 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Covid19, Comorbidities and Coexisting Conditions, Risk Factor, SARS-CoV-2, COVID-19 Second Wave, COVD-19 First Wave, Death