Interest of Branched Chain Amino Acids Associated With a Respiratory Rehabilitation Program in Patients Broncho Chronic Obstructive Pulmonary Disease

Study Overview
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Brief Summary
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Respiratory rehabilitation is one of the main treatments for COPD in the early stages of the disease (Stage 2 of GOLD) with a recognized effect on improving the capacity of the patients to exert effort by fighting against deconditioning. the effort. This treatment also improves the quality of life of patients and reduces the risk of respiratory exacerbations. The patients are very often malnourished and various studies have proposed the addition of oral supplementation such as hormone therapy (testosterone) to improve the exercise performance of these atrophied muscles. The use of branched-chain amino acids (AARs) such as valine, leucine, isoleucine in this indication can be fully justified because they stimulate protein synthesis and promote muscle maintenance and repair.

Official Title
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Interest of Branched Chain Amino Acids Associated With a Respiratory Rehabilitation Program in Patients Broncho Chronic Obstructive Pulmonary Disease. Randomized Study Against Placebo

Conditions
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Broncho Chronic Obstructive Pulmonary Disease

Intervention / Treatment
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* Drug: Amino Acids
* Drug: Placebos


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients Broncho Chronic Obstructive Pulmonary Disease in stages 2 and 3 of the GOLD classification, whose Maximum Expiratory Volume on the first second is between 30% and 80% of the expected theoretical value, associated with a maximal expiratory volume ratio on the first Second / Vital Capacity less than or equal to 70% of the expected theoretical value. Patients of both sexes, aged 40 to 80 years In case of active smoking, patients must commit to interrupting it during the respiratory rehabilitation program that will be proposed to them in this study Exclusion Criteria: - Age <40 years or> 80 years Patients with a contraindication to exercise, Phenylketonuria Patients treated with long-term oxygen therapy and / or home ventilation will not be included. Patients with acute respiratory decompensation in the three months prior to inclusion. Patients with known allergy to milk, gluten, soy, egg and nuts Patients taking part in another clinical trial or who have participated in a clinical trial in the 3 months preceding this study.

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Retraining with respiratory effort+ amino acids<br> | Drug: Amino Acids<br>* Sweet taste cocoa flavored drink<br>|
| Placebo Comparator: Retraining with respiratory effort+ placebo<br> | Drug: Placebos<br>* Sweet taste cocoa flavored drink<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| maximum oxygene uptake | maximum oxygene uptake measured during intensive exercise | after 6 weeks of treatment |