Real-time MRI for Evaluating Cardiac Volumetry

Study Overview
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Brief Summary
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This study will compare the accuracy of a real-time Cine sequence in assessing cardiac volumetry.

Detailed Description
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This is a single-centre prospective study involving up to 570 patients with known or suspected cardiac disease referred for routine clinical cardiovascular magnetic resonance (CMR) assessment at Glenfield General Hospital, Leicester. In addition to standard multi-breath-hold steady-state free precession (SSFP) imaging (undertaken as part of the routine scan), each patient will also undergo additional imaging with a non-breath-hold multi-slice real-time cine sequence. The primary outcome is the assessment of cardiac volumetry and function (end-diastolic volume, end-systolic volume, stroke volume, ejection fraction and myocardial mass) as measured by (1) the standard multi-breath-hold SSFP technique and (2) the non-breath-hold multi-slice real-time cine sequence. Secondary outcome measures will be (1) the time required for each scan, and (2) image quality for each scan. An additional secondary outcome will be to compare indexed cardiac volumes with those indexed according to measured body-surface area.

Official Title
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Comparison of Standard Breath-hold Cardiac MRI With a Faster, Free-breathing Scan

Conditions
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Left Ventricle Abnormality

Intervention / Treatment
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* Diagnostic Test: cardiovascular magnetic resonance


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged ≥ 18 years Referred for routine CMR imaging Willing and able to give informed consent Willing and able to comply with the requirements of the study Able to understand written English Exclusion Criteria: Severe claustrophobia Absolute contraindications to CMR (those with CMR conditional or safe devices will be eligible for inclusion) Unable to provide informed consent Participants unable to understand written English

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: cardiovascular magnetic resonance|CMR scan at 3 Tesla|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiac volumetric assessment 1 | Left ventricular ejection fraction | 1 day | 
| Cardiac volumetric assessment 2 | Left ventricular end-diastolic volume | 1 day | 
| Cardiac volumetric assessment 3 | Left ventricular myocardial mass | 1 day | 
| Cardiac volumetric assessment 4 | Right ventricular ejection fraction | 1 day | 
| Cardiac volumetric assessment 5 | Right ventricular end-diastolic volume | 1 day | 
| Cardiac strain assessment 1 | Left ventricular global longitudinal strain | 1 day | 
| Cardiac strain assessment 2 | Left ventricular global circumferential strain | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time | the time required for each scan under evaluation (real-time Cine and standard Cine) | 1 day | 
| Image quality assessment | Image quality of each scan component, assessed visually on a 4-point score - excellent (3), good (2), moderate (1) and poor (0). | 1 day | 
| Body-surface area | planimetered body-surface area | 1 day |