The Efficacy of Urine Biomarker in Patient With Interstitial Cystitis/Painful Bladder Syndrome (Pilot Study)

Study Overview
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Brief Summary
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This study is to evaluate the efficacy of urine biomarker in patients with interstitial cystitis/painful bladder syndrome

Official Title
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The Efficacy of Urine Biomarker in Patient With Interstitial Cystitis/Painful Bladder Syndrome

Conditions
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Chronic Interstitial Cystitis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: must have experienced bladder pain, urinary urgency and frequency for at least 6 months prior to entry into the study Pain VAS >4 PUF score >13 ICQ score >12 4) cystoscopic record within 2years Exclusion Criteria: Patients who are pregnancy or, childbearing age without no contraception Patient with microscopic hematuria, if not excluded that no evidence of neoplastic tumor examination patients with urine culture showing evidence of urinary tract infection 1month prior to the study Accompanied medical problem below Tuberculosis in urinary system Bladder cancer, urethral cancer, Prostate cancer Recurrent cystitis Anatomical disorder Patients had prior surgery (bladder augmentation, cystectomy) Patients with neurologic disorder Patients with indwelling catheter or intermittent self-catheterization Patients with psychological problem

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Interstitial cystitis<br>Patients who have been diagnosed with interstitial cystitis/bladder pain syndrome. The group includes both patients with or without Hunner lesion on cystoscopy | |
| Control<br>Adult participants without history of interstitial cystitis/bladder pain syndrome | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference of RNA expression of the urine biomarker between the interstitial cystitis and control groups | Difference of RNA expression of the urine biomarker between the interstitial cystitis and control groups | 1day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference of RNA expression of the urine biomarker between Hunner ulcer interstitial cystitis and non-ulcer interstitial cystitis groups | Difference of RNA expression of the urine biomarker between Hunner ulcer interstitial cystitis and non-ulcer interstitial cystitis groups | 1day | 
| Difference of RNA expression of the urine biomarker in interstitial cystitis according to pain score on the visual analogue scale | Difference of RNA expression of the urine biomarker in interstitial cystitis according to pain score on the visual analogue scale | 1day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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biomarker, interstitial cystitis