Vitamin D and Serum Calcium Level Insufficiency and Early Dental Implant Failure

Study Overview
=================
Brief Summary
-----------------
In this study there is a trial to investigate whether there is a correlation between early implant failure and low serum levels of vitamin D.

Detailed Description
-----------------
Osseointegration is a complex phenomenon and depends on many factors; some are related to the implant (material, macroscopic design, and implant surface), others to the surgical-prosthetic protocol (surgical technique, loading conditions, and time), and others to the patient (quantity/quality of bone at the receiving site and the host response) All these observations would suggest the existence of specific patient-related risk factors such as vitamin D deficiency in the blood, could play an important role in the occurrence of early dental implant failures (EDIFs), but unfortunately are neglected by the dental literature. In this study there is a trial to investigate whether there is a correlation between early implant failure and low serum levels of vitamin D. Therefore we are including patients with early implant failure during the year 2020 using the same implant (material, macroscopic design, and implant surface), surgical-prosthetic protocol (surgical technique, loading conditions, and time) The study will be performed into 15 male and 15 female participants that had dental implant placement in the last 3 months. An informed consent will be signed with the patient with full detail on the study. The situation of the implant will be categorized into either successful or failed dental implant. Medical history and lifestyle information will be obtained by questionnaire. Levels of serum vitamin D will be collected from participants Statistical analysis will correlate between vitamin D and early implant failure.

Official Title
-----------------
Correlation Between Vitamin D and Serum Calcium Level Insufficiency and Early Dental Implant Failure

Conditions
-----------------
Vitamin D Deficiency, Dental Implant Failure Nos

Intervention / Treatment
-----------------
* Diagnostic Test: Vitamin D and calcium levels


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Missing single tooth Systemically free Average body mass index Exclusion Criteria: Systemic conditions Bad oral hygiene

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Successful dental implant<br>Patients showed a successful implant placement with no complications before loading | Diagnostic Test: Vitamin D and calcium levels<br>* Mini VIDAS® compact multiparametric immunoanalyzer for vitamin D analysis (BIOMERIEUX- France)<br>|
| Early dental implant failure<br>Early complications and failure of dental implant before loading | Diagnostic Test: Vitamin D and calcium levels<br>* Mini VIDAS® compact multiparametric immunoanalyzer for vitamin D analysis (BIOMERIEUX- France)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Implant success with normal serum vitamin D level | Implant stability with no further radiographic bone loss following bone remodeling with successful prosthetic part | 6 months | 
| Early implant failure with deficient serum vitamin D level | Mobile extruded implant with radiographic bone loss and peri-implant pathosis | 6 months |