RPSA as a Potential Prognostic Biomarker of Pancreatic Cancer

Study Overview
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Brief Summary
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PDAC (Pancreatic ductal adenocarcinoma) represents 90% of pancreatic tumors. The prognosis of PDAC remains poor at this time. Its management is based on surgery for early stages, associated with neoadjuvant and adjuvant chemotherapy. However, around 80% of patients will relapse after surgery. There is a lack of efficient biological biomarkers of PDAC, especially for prognosis. To date, CA19-9 is commonly used despite its lack of sensitivity and specificity. Ribosomal protein SA (RPSA) is a transmembrane receptor localized at the cell surface but also in the cytosolic and nuclear regions. RPSA interacts with many proteins in the extracellular matrix (ECM), including laminin-1 and elastin. RPSA in involved in different cellular functions such as cell adhesion, migration, proliferation and differentiation. The expression of RPSA is increased in many cancers including breast, lung, prostate, pancreatic, etc. It could represent a molecular biomarker of tumor invasion and metastatic abilities. Moreover, the concentration of RPSA could be measured in the serum of patients with PDAC. Recent data suggest that a modification of the RPSA concentration could be a prognostic biomarker of PDAC.

Detailed Description
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The aim of this study is to explore the potential implication of RPSA as prognostic biomarker of PDAC.

Official Title
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RPSA as a Potential Prognostic Biomarker of PDAC

Conditions
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Pancreatic Ductal Adenocarcinoma (PDAC)

Intervention / Treatment
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* Other: Blood sample


Participation Criteria
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Eligibility Criteria
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inclusion criteria : Patients treated at the Reims University Hospital for a resectable or potentially resectable pancreatic tumor, with or without neoadjuvant chemotherapy Adults (aged more than 18 years old) Patients who have signed the informed consent form exclusion criteria : Patients with a prior history of cancer (excluding basal cell carcinoma or in situ cervical cancer that received conventional cancer treatment). Minors Patients for whom PDAC is not the retained diagnosis

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: pancreatic adenocarcinoma patient<br>patient with pancreatic ductal adenocarcinoma | Other: Blood sample<br>* Blood sample<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| RPSA serum concentration | The RPSA serum concentration is assessed with commercially available RPSA ELISA assay (MyBioSource - MBS9137288). | Day 0 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pancreatic ductal adenocarcinoma, Ribosomal protein SA (RPSA), prognosis biomarker