Predictive Factor Study of the Occurrence of Endometrial Cancer in Patients With Lynch Syndrome

Study Overview
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Brief Summary
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Lynch Syndrome increases Endometrial Cancer Occurrence in women due to failure in MisMatch Repair System. Lifetime Cumulative risk of developing endometrial Cancer is approximatively 40% in women with Lynch Syndrome. Endometrial cancer is the third women cancer in France. Many risk factors are known in general population. Lots of factors are related to over exposure to estrogen. Data about influence of general risk factors in Women with Lynch Syndrome are poor. Recently, a cohort study appears to have shown a significant decrease in the risk of endometrial cancer with multiparity, the use of hormonal contraception and late menopause in Lynch women. The impact of weight and certain metabolic parameters on the occurrence of endometrial cancers remains poorly known to this day.

Official Title
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Predictive Factor Study of the Occurrence of Endometrial Cancer in Patients With Lynch Syndrome: Study Conducted in the Hauts-de-France

Conditions
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Lynch Syndrome

Intervention / Treatment
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* Other: questionnaire assesment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Lynch Syndrome Diagnosis at University Hospital Alive at study time Age over 30 at endometrial cancer or Lynch Syndrome Diagnosis Case group : - No cancer before endometrial cancer diagnosis Control group : No endometrial cancer developped Free cancer women at Lynch Syndrome diagnosis Exclusion Criteria: Refusing to participate Poor understanding of the French language Other cancer diagnosed before endometrial cancer Hysterectomy before lynch diagnosis for free cancer women

Ages Eligible for Study
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Minimum Age: 30 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| case group<br>Women with Lynch Syndrome and endometrial Cancer matched on age of endometrial cancer diagnosis | Other: questionnaire assesment<br>* Each patient will to answer questions about their medical history.<br>|
| control group<br>Women with Lynch Syndrome, without Cancer at Lynch Syndrome Diagnostic matched on their age at Lynch Diagnostic | Other: questionnaire assesment<br>* Each patient will to answer questions about their medical history.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between endometrial cancer and predictif factors | Endometrial cancer (yes/no) and explicative variable: Diabetes before endometrial cancer or Lynch syndrome diagnosis; Smoking ; Maximal Weight ; Age at menarche; Parity ; Age at first birth ; Contraceptive use. | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between endometrial cancer and predictif factors in post menopausal woman | Endometrial cancer (yes/no) and explicative variable: Menopause age; Hormonal menopause treatment | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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lynch syndrome, endometrial cancer