Posturography-Neuropathy

Study Overview
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Brief Summary
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If the classification between hereditary and acquired neuropathy is often easy, there is no completely specific marker allowing the distinction between the two etiologies. Clinical experience suggests that hereditary neuropathies have less impact on balance and gait than the acquired neuropathies at equivalent level of impairment, but this has never been clearly demonstrated.

Official Title
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Study of Gait and Posture in Subacute Acquired Neuropathies and in Hereditary Neuropathies

Conditions
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Neuropathy Demyelinating

Intervention / Treatment
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* Other: Motion analysis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: CMT1A for molecular-proven Group 1 (PMP22 duplication) IPDC likely or defined for Group 2 Able to walk 10 m unassisted Exclusion Criteria: Neurological history other than neuropathy: epilepsy, stroke, dementia Pregnant women Person under guardianship or trusteeship Musculoskeletal conditions other than neuropathy impairing walking abilities Major comorbidity considered a contraindication by the investigator (cancer, unstable angor, etc.)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: demyelinating hereditary neuropathy<br>adult patients with demyelinating hereditary neuropathy type CMT 1A. | Other: Motion analysis<br>* Gait and posture recording<br>|
| Experimental: demyelinating inflammatory neuropathy<br>adult patients with acquired demyelinating inflammatory neuropathy. | Other: Motion analysis<br>* Gait and posture recording<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Posturography (Romberg's quotient) |  | Time 0 ; single session | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The Timed Up and Go test (TUG) | It uses the time that a person takes to rise from a chair, walk three meters, turn around, walk back to the chair, and sit down. the scores of ten seconds or less indicate normal mobility, 11-20 seconds are within normal limits for frail elderly and disabled patients, and greater than 20 seconds means the person needs assistance outside and indicates further examination and intervention. A score of 30 seconds or more suggests that the person may be prone to falls | Time 0 ; single session | 
| stride length (in millimeters) parameters | Kinematic and Kinetic parameters of the gait initiation and the stabilised gait using the optoelectronic system (VICON®) | Time 0 ; single session | 
| stride time (in seconde) parameters | Kinematic and Kinetic parameters of the gait initiation and the stabilised gait using the optoelectronic system (VICON®) | Time 0 ; single session | 
| velocity (meter/seconde) parameters | Kinematic and Kinetic parameters of the gait initiation and the stabilised gait using the optoelectronic system (VICON®) | Time 0 ; single session | 
| cadence (step/min) parameters | Kinematic and Kinetic parameters of the gait initiation and the stabilised gait using the optoelectronic system (VICON®) | Time 0 ; single session | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Gait, Balance, Posture, Charcot-Marie-Tooth, Chronic inflammatory demyelinating polyneuropathy