Incontinence and MRI Results in Children With Cerebral Palsy

Study Overview
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Brief Summary
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More than 50 % of children and adults with cerebral palsy experience lower urinary tract symptoms (LUTS). This can negatively influence quality of life of the child and the total social environment. Previous research demonstrated that the brain lesion, characteristic for cerebral palsy (CP), is a prognostic factor for the functional abilities of a child with CP. Previous research within our department demonstrated functional impairment as a risk factor for incontinence. This demonstrates an indirect connection between the brain lesion and incontinence of a child with CP. However, this connection isn't alway correct as some children with high functionality also demonstrate incontinence. As bladder control is also regulated by higher brain centers, the present study wants to investigate a direct connection between the brain lesion of the child, visible by means of MRI, and the incontinence status of the child. .

Detailed Description
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The current study is a cross-sectional observational study in which a correlation is investigated between known anatomical MRI results and the continence status of a child with CP. Although neuroimaging isn't seen as a requirement for the definition and diagnosis of CP2, MRI imaging is often part of diagnostic evaluation. The Surveillance of Cerebral Palsy in Europe (SCPE) working group composed the MRI classification system or MRICS classifying neuroimaging results in maldevelopments, predominant white matter injury, predominant grey matter injury, miscellaneous and normal. These results will be correlated with results of the validated Vancouver symptoms score for dysfunctional elimination syndrome.

Official Title
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Correlation Between Brain Lesion and Continence in Children With Cerebral Palsy: an Anatomical MRI Study

Conditions
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Cerebral Palsy, Lower Urinary Tract Symptoms

Intervention / Treatment
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* Other: Vancouver symptom score for dysfunctional elimination syndroms
* Other: Magnetic resonance imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis of cerebral palsy MRI investigation in history Dutch or French speaking child and parent Exclusion Criteria: No MRI investigation in history Child or parent not speaking Dutch or French

Ages Eligible for Study
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Minimum Age: 5 Years
Maximum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Vancouver symptom score for dysfunctional elimination syndroms|Validated questionnaire concerning bladder and bowel symptoms|
|Other: Magnetic resonance imaging|Known MRI results of the patient file|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incontinence ratio | Amount of patients with incontinence in the different MRICS-groups (MRI classification system for children with CP). | During cross-sectional testing | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Amount of Lower urinary tract symptoms in different MRICS-groups | Score of 'Vancouver symptom score for dysfunctional elimination syndrome'-questionnaire and individual questions in the different MRICS- groups (MRI classification system for children with CP). | During cross-sectional testing | 
| Amount of bladder symptoms in different MRICS-groups | Score of individual questions from the 'Vancouver symptom score for dysfunctional elimination syndrome' questionnaire in the different MRICS- groups (MRI classification system for children with CP). | During cross-sectional testing | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cerebral palsy, lower urinary tract symptoms, Magnetic resonance imaging, brain lesion, incontinence