Association of Serum Ferritin and Bone Mineral Density With Bone Metabolism in Chinese Healthy Postmenopausal Women

Study Overview
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Brief Summary
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Large amounts of experimental and animal evidence have confirmed that iron accumulation is associated with bone loss. However, it is still lack of the clinical studies relating iron accumulation to bone loss, especially in the pathological conditions during our Chinese. In this study, the investigators aim to assess the association between the levels of serum ferritin and bone mineral density in Chinese healthy postmenopausal women.

Detailed Description
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For the past few years, an increasing number of in vitro studies show the association of iron accumulation with bone loss, particularly in postmenopausal women. And body iron accumulation is accurately reflected by levels of serum ferritin in clinic. The levels of serum ferritin among healthy women are about 13-150μg/L, and we give a definition of iron accumulation when serum ferritin range from 500μg/L to 1000 μg/L. How will the bone mineral density change in iron accumulation? The investigators intend to perform this study to explore and establish the relational function and logical function between serum ferritin, bone mineral density and biochemical markers of bone metabolism in Chinese healthy postmenopausal women.

Official Title
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A Observational Study to Investigate the Relationship of Levels of Serum Ferritin, Bone Mineral Density and Bone Metabolism in Chinese Healthy Postmenopausal Women

Conditions
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Postmenopausal Osteoporosis, Iron Metabolism Disorders

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy postmenopausal women subjects aged 55 years or older Exclusion Criteria: subjects with acute or chronic inflammatory or infectious diseases chronic liver or renal diseases history of transfusion or iron therapy in the previous year history of drug therapy such as bisphosphonates and glucocorticoids, which might have affected bone metabolism subjects with hematonosis

Ages Eligible for Study
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Minimum Age: 55 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The concentrations of serum ferritin | Serum ferritin was assayed by an immunoradiometric method. | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bone turnover markers(BTMs) | BTMs are classified as indices of either bone resorption or formation. During this study, we detect serum collagen type 1 cross-linked C-telopeptide(bone resorption marker) and Procollagen type I N-terminal propeptide(Bone formation marker). | 12 months | 
| Bone mineral density(BMD) | Bone mineral density (BMD) in femur and lumbar spine were measured by dual-energy X-ray absorptiometry. | 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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bone mineral density, bone turnover markers, ferritin