Adductor Canal Block and Arthroscopic Knee Surgery, High Pain Responders

Study Overview
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Brief Summary
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The investigators want to explore the analgesic effect of Adductor Canal Blockade (a peripheral nerve block) in high pain responding patients after arthroscopic knee surgery. The investigators hypothesize that the nerve block will have an abrupt analgesic effect.

Official Title
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The Analgesic Efficacy of the Adductor Canal Blockade in High Pain Responders After Arthroscopic Knee Surgery - a Randomized Clinical Trial

Conditions
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Arthroscopic Knee Surgery

Intervention / Treatment
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* Procedure: Intervention group, block no. 1 - Ropivacain
* Procedure: Control group: 1. block - saline


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Arthroscopic knee surgery, if reconstruction of Anterior Cruciate Ligament only hamstring graft 18-80 years of age BMI 18-40 ASA I-III written Consent Exclusion Criteria: Unable to communicate in danish, allergic reactions toward any study medication pregnancy alcohol/drug abuse daily opioid consumption scin infection (injection site)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention group, block no. 1 - Ropivacain<br>Adductor-Canal-Block no.1: 30mL ropivacaine (7.5 mg/ml) when postoperative VAS-score is > 40mm (on a 0-100 mm VAS-scale) during a 45 degree active flexion of the knee. Adductor-Canal-Block no.2: after 45 min (t45) - 30mL isotonic saline. | Procedure: Intervention group, block no. 1 - Ropivacain<br>* Intervention group: 1. block ropivacaine - 2. block saline<br>|
| Sham Comparator: Control group, block no. 1 - saline<br>Adductor-Canal-Block no.1: 30mL isotonic saline when postoperative VAS-score is above 40mm (on a 0-100 mm VAS-scale) during a 45 degree active flexion of the knee. Adductor-Canal-Block no.2: after 45 min (t45) - 30mL ropivacaine (7.5 mg/ml) | Procedure: Control group: 1. block - saline<br>* Control group: 1. block saline - 2. block ropivacaine<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain score during 45 degree flexion of the knee | Pain score during flexion of the knee 45 min. after nerve block | 45 minutes after nerve block | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain score | pain score at rest: time 0,15,30,45,60,75,90 min. after first nerve block pain score during flexion of the knee: time 0,15,30,45,60,75,90 min. after first nerve block pain score during mobilisation (5m walk): 45 and 90 min after nerve block | 0-90 min. after first nerveblock | 
| muscle strength | patients accesses muscle strength during walk | 45 and 90 min after nerve block | 
| Opioid consumption |  | 0-90 min after nerve block | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Minor arthroscopic knee surgery including ACL-reconstruction (hamstrins graft), High pain responders, Adductore Canal Block, Analgesics, Ultrasound guided nerve block