Cognitive Training in Inpatient Treatment for Substance Use Disorders

Study Overview
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Brief Summary
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This study examines whether computer tasks can improve memory and other cognitive functions among patients receiving inpatient treatment for substance use disorders.

Detailed Description
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Participants will complete cognitive training sessions on a regular basis during inpatient treatment. Alternate versions of the computer tasks will be compared in a randomized design. Primary and secondary outcomes will consist of changes in cognitive performance before and after the training period.

Official Title
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Cognitive Training in Inpatient Treatment for Substance Use Disorders

Conditions
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Substance Use Disorders

Intervention / Treatment
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* Behavioral: Cognitive training activities
* Behavioral: Inpatient psychosocial therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participants must be patients registered for inpatient treatment at the Centre for Addiction and Mental Health Age 18-60 Fluency in English Able to attend scheduled training sessions Comfortable using a computer and mouse Exclusion Criteria: Severe cognitive impairment Current or past psychosis or diagnosis of schizophrenia Photosensitive epilepsy or history of seizures triggered by light Legal mandate to attend treatment

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Experimental<br>Computerized cognitive training activities | Behavioral: Cognitive training activities<br>* Training activities consist of computer tasks designed to improve memory and cognition. The intervention consists of 45-minute training sessions delivered regularly during inpatient treatment.<br>Behavioral: Inpatient psychosocial therapy<br>* Group psychosocial therapy delivered in an inpatient setting.<br>|
| Active Comparator: Control<br>Non-adaptive computerized cognitive training activities | Behavioral: Cognitive training activities<br>* Training activities consist of computer tasks designed to improve memory and cognition. The intervention consists of 45-minute training sessions delivered regularly during inpatient treatment.<br>Behavioral: Inpatient psychosocial therapy<br>* Group psychosocial therapy delivered in an inpatient setting.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Auditory memory capacity - WAIS Digit Span score | WAIS Digit Span score | Baseline, 3 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Auditory memory capacity - WAIS Letter-number sequencing score | WAIS Letter-number sequencing score | Baseline to 3 weeks | 
| Visual memory capacity - WMS Spatial span score | WMS Spatial span score | Baseline to 3 weeks | 
| Visual memory capacity - WMS Symbol span score | WMS Symbol span score | Baseline to 3 weeks | 
| Training progress score - Cognitive progress indicator score | Cognitive progress indicator score | Baseline to 4 weeks |