Evaluation of the Clinical, Neuropsychological and Psychosocial Situation of Patient With Eating Disorders.

Study Overview
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Brief Summary
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Eating disorders (ED) are serious mental illnesses with an excess mortality and many affects in the quality of life of patients and thier relatives. Management of ED is very difficult : the prognosis remains relatively poor both in terms of remission rate and quality of life. In this context, the contribution of new strategies for pathophysiological exploration and the development of therapeutic options are crucial. In this project the investigators aim to constitute un cohort of patients from a day unit specialized in the management of ED. A prospective follow-up will be offered to patients to assess their clinical and psycho-social evolution. The overall objective is to identify which factors are prognostic of clinical improvement of the ED. We also want to better characterize patients that will migrate from diagnosis to another.

Detailed Description
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The investigators propose to assess, with a cohort of patients with ED the prognostic value of cognitive abnormalities associated with ED (cognitive flexibility and central coherence) They will recruit 370 patients suffering from a current ED (anorexia, bulimia, binge eating disorder, Eating disorder not otherwise specified). Each patient will be reassessed every year for 3 years.

Official Title
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Evaluation of the Clinical, Neuropsychological and Psychosocial Situation of Patient With Eating Disorders.

Conditions
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Eating Disorders

Intervention / Treatment
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* Other: Clinical assessment


Participation Criteria
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Eligibility Criteria
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Inclusion criteria: respond to DSM 4 criteria for ED Age 15 to 65 years Signing an informed consent. Affiliated to a social security scheme or being the beneficiary of such a scheme. Exclusion criteria: Manifest inability of the subject to understand / perform clinical and neuropsychological evaluations and tasks Major protected by law (guardianship) Privation of liberty by judicial or administrative decision Pregnant or lactating women

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Eating disorders<br> | Other: Clinical assessment<br>* Clinical assessment with questionnaires<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Frequency of remission rates | study of remission rates frequency at 12 months depending on the Brixton score assessed at baseline (assessment of cognitive flexibility). Remission is defined as disappearance of ED Diagnostic and Statistical Manual (DSM) criteria. | At the inclusion and at 12, 24 and 36 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| score to another neuropsychological test (Iowa gambling task (IGT) | Study of remission rates frequency at 12 months depending on the IGT score (decision making) assessed at baseline | At the inclusion and at 12, 24 and 36 months | 
| scores to another other neuropsychological test : Rey-Osterrieth complex figure | Study of remission rates frequency at 12 months depending on the Rey figure assessed at baseline | At the inclusion and at 12, 24 and 36 months | 
| scores to another neuropsychological test : D2 test of attention | Study of remission rates frequency at 12 months depending on the D2 test (attention) assessed at baseline | At the inclusion and at 12, 24 and 36 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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eating disoders, neuropsychology, pronostic