Systemic Inflammatory Response Evaluation With the Use of Inhaled Anesthetic Sevoflurane During CPB

Study Overview
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Brief Summary
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Cardiac surgery has evolved considerably after the advent of cardiopulmonary bypass (CPB), a feature that allowed more precision and tranquility to the heart surgeon. But their influence on exacerbation of inflammatory response can unbalance the whole homeostasis so happens surgical trauma. The attenuation of the systemic inflammatory response in major surgeries like cardiac surgery for aortic aneurysm appears to represent an important advance in reducing morbidity and mortality of these patients. Some studies suggest that inhaled anesthetics such as sevoflurane appear to play an important role in this control, but the mechanism by which this happens is still unclear. This study has the primary purpose of analyzing from a clinical study sevoflurane inhalation anesthetic can change the inflammatory response induced by CPB, significantly reducing the release of inflammatory markers, especially elastase PMN.

Official Title
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Systemic Inflammatory Response Evaluation With the Use of Inhaled Anesthetic Sevoflurane During CPB

Conditions
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Inflammatory Response

Intervention / Treatment
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* Drug: Sevoflurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age over 18 years Cardiac Surgery elective of coronary artery bypass graft with cardiopulmonary bypass (CPB) The informed consent signature savvy Exclusion Criteria: Use of steroids or anti-inflammatory drugs routine Presence of asthma, COPD, autoimmune diseases Participation in other clinical studies Presence of decompensated heart failures, liver or kidney Combined elective surgery (ex .: aneurysm correction + CABG) Acute myocardial infarction in the last 30 days Unstable angina And obesity (BMI> 50kg / m2)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sevoflurane Group<br>Group of patients receiving sevorane during extracorporeal circulation period. | Drug: Sevoflurane<br>* The Sevoflurane Group will receive between 0.7 and 1.5% of sevoflurane CAM only during CPB period. While Not Sevoflurane Group will receive only intravenous anesthetic agents.<br>|
| Not Sevoflurane Group<br>Group of patients who did not receive the sevorane during extracorporeal circulation period. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reduction of systemic inflammatory response | Cytokines are assayed in both groups at 4 different times in order to check the impact of sevoflurane on the inflammatory response. The first one is the baseline of measurement with which the others are compared and all will be compared within and between groups. | Through study completion, an average of 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Sevoflurane, MicroRNAs, Inflammatory Response, Cytokines, Anesthetics, Inhalation, Macrophage Inflammatory Proteins