linjc16/ctgov huggingface dataset:
A Study to Evaluate 4DCT Controls

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to use CT motion pictures (4DCT) to visualize and record how much space there is between certain wrist joint bones, both without any resistance and with light resistance to the movement, during a single scanning visit.

Official Title
-----------------
4DCT Wrist Biomarkers During Resisted and Unresisted Tasks in Healthy Controls

Conditions
-----------------
Wrist Ligament and Bone Disorders

Intervention / Treatment
-----------------
* Device: 4DCT


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criterion: Age ≥ 18 and ≤ 60 years. Control subjects without any history of wrist injury or disease. Exclusion Criteria (applied to both wrists for control subjects): Previously-diagnosed rheumatological conditions or connective tissue diseases; Inability to be appropriately positioned in the scanner for the imaging; Congenital malformations of the wrist or forearm; Diagnosed wrist osteoarthritis Age under 18 or over 60.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Healthy Controls<br> | Device: 4DCT<br>* CT imagining conceptually similar to time-lapse photography.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Scapholunate gapping | Normalized volar/dorsal location of the gapping at the scapholunate joint, measured in millimeters, at each of the 17 time steps during each movement. | Baseline | 
| Radioscaphoid gapping | Normalized volar/dorsal location of the gapping at the radioscaphoid joint, measured in millimeters, at each of the 17 time steps during each movement. | Baseline | 
| Radiolunate gapping | Normalized volar/dorsal location of the gapping at the radiolunate joint, measured in millimeters, at each of the 17 time steps during each movement. | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Scaphotrapezium gapping | Normalized volar/dorsal location of the gapping at the radiolunate joint, measured in millimeters, at each of the 17 time steps during each movement. | Baseline | 
| Scaphotrapezoid gapping | Normalized volar/dorsal location of the gapping at the radiolunate joint, measured in millimeters, at each of the 17 time steps during each movement. | Baseline | 
| Trapezoitrapezoid gapping | Normalized volar/dorsal location of the gapping at the radiolunate joint, measured in millimeters, at each of the 17 time steps during each movement. | Baseline |
Cognitive Training for Patients With Schizophrenia

Study Overview
=================
Brief Summary
-----------------
This research on cognitive training addresses the following questions: Does cognitive training lead to improved cognition, functional abilities, psychiatric symptoms, treatment adherence, or quality of life in patients with psychoses? What are the neurocognitive and non-cognitive factors that predict good outcomes following cognitive rehabilitation? In addition to verbal learning and memory, immediate verbal memory, vigilance, and executive functioning, the cognitive training intervention attempted to improve prospective memory ability (i.e., the ability to remember to do things in the future, such as take medications or attend a doctor's appointment).

Official Title
-----------------
Cognitive Training for Patients With Schizophrenia

Conditions
-----------------
Schizophrenia, Schizoaffective Disorder, Other Primary Psychotic Disorders

Intervention / Treatment
-----------------
* Behavioral: Cognitive Training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Primary psychotic disorder (including schizophrenia, schizoaffective disorder, psychotic mood disorder, or psychosis NOS) Age 18 or older Fluency in English Exclusion Criteria: Dementia Neurological conditions affecting cognition Mental retardation Substance use disorder within the past month Participation in other intervention trials

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cognitive Training<br>Cognitive training group | Behavioral: Cognitive Training<br>* 12-week compensatory cognitive training in group format<br>|
| No Intervention: Standard Pharmacotherapy<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| UCSD Performance-based Skills Assessment Total Score (Measures Functional Capacity) | Performance-based measure of functional capacity in five domains: Communication, Finance, Recreation Planning, Transportation, and Household Chores Scale ranges from 0-100. Subscales are summed to yield the total score. Higher scores represent better performance. | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hopkins Verbal Learning Test Percent Retained | Verbal list learning task with three learning trials and a delay trial. Percent retained refers to the percentage of items recalled at the delay trial, compared to the third learning trial. Score ranges from 0-100. Higher scores represent better performance. | 3 months |
Assessment of Frailty in Patients With Advanced Hepatocellular Cancers

Study Overview
=================
Brief Summary
-----------------
This study is looking at the feasibility of performing frailty assessments on patients with advanced hepatocellular cancer.

Detailed Description
-----------------
This study is primarily looking to see if it is feasible to assess frailty in patients with advanced hepatocellular cancer. It is also evaluating whether there may be any correlation between these assessments and toxicity of treatment and outcome. The assessments include: Frailty score, nutritional assessment, comorbidity score and quality of life. In addition sarcopenia will be assessed measuring muscle mass from imaging performed as part of routine clinical care. The assessments will be performed at baseline on entry into the study, at week 9 and week 18. There is the option for patients to also donate a blood samples for research purposes.

Official Title
-----------------
Assessment of Frailty in Patients With Advanced Hepatocellular Cancers

Conditions
-----------------
Hepatocellular Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with a diagnosis of hepatocellular cancer not suitable for curative treatment Seen by an oncologist or hepatologist for consideration of palliative treatment and a decision regarding management already made WHO Performance status 0-2 Childs Pugh Score A or B Written informed consent Exclusion Criteria: N/A -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage patients consenting for assessment out of number of patients approached | Number of patients consenting for the study as a percentage of the number of patients approached about the study | baseline | 
| Time taken to complete assessments | Time taken to completed assessments recorded by clinical trials officer | Baseline, week 9 and week 18 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Frailty as a predictor of grade 3/4 toxicity | Frailty score at baseline and during study time predict for outcome | Baseline, week 9 and week 18 | 
| Muscle mass and timed get up and go as predictors of outcome | muscle mass as measured on routine CT scans and get up and go as measured in frailty score | Baseline, week 9 and week 18 |
Immunotherapy With Autologous Dexosomes for Patients With Stage IV Melanoma

Study Overview
=================
Brief Summary
-----------------
The objective is to determine the safety and efficacy of dexosome immunotherapy in patients with Stage IV malignant melanoma

Official Title
-----------------
A Phase II, Multicenter, Open-Labeled Study of Immunotherapy With Autologous Dexosomes for Patients With Stage IV Melanoma

Conditions
-----------------
Melanoma

Intervention / Treatment
-----------------
* Biological: autologous dexosomes loaded with tumor-specific peptides


Participation Criteria
=================
Eligibility Criteria
-----------------
Patients with Stage IV metastatic melanoma with 0-1 prior treatments for metastatic disease. All patients must have distant skin, subcutaneous, or nodal metastases (M1a) or lung metastases (M1b), measurable disease, normal lactate dehydrogenase levels, and HLA type A1, A2, or B35. Patients must have adequate organ function and an estimated life expectancy of at least 3 months.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: autologous dexosomes loaded with tumor-specific peptides|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Ultrasound Guided Thoracic Paravertebral Block for Hepatic Tumors Ablation

Study Overview
=================
Brief Summary
-----------------
Patients undergo percutaneous radiofrequency ablation of hepatic tumors at Siriraj hospital normally receive only intravenous sedative drugs which sometimes can not provide effective pain control. TPVB is suitable for unilateral operations. And it is increasing popular nowadays because of using ultrasound guided which make it is more reliable and has less side effects especially the severe one such as pneumothorax. To cover all nerve supply liver, we decided to use right TPVB at T5-6, T7-8, and T9-10. The aim of this study is to prove that TPVB can provide an effective pain control for patients undergo liver RFA both at rest and movement (cough). We are going to measure the pain score at recovery room and the effective pain control means patients has mild pain (pain score less </= 3 and do not ask for analgesic drugs).

Official Title
-----------------
Ultrasound Guided Thoracic Paravertebral Blocks: An Effective Pain Control in Percutaneous Radiofrequency Ablation of Hepatic Tumors

Conditions
-----------------
Liver Cancer

Intervention / Treatment
-----------------
* Drug: 0.5% marcaine 20ml


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age > 18 years Patients undergo percutaneous radiofrequency ablation for liver tumors ASA classification 1-3 Exclusion Criteria: Psychiatric illness Chronic abdominal pain > 1 week Regular analgesic drugs use Infection at back (Block area) Severe spinal deformity PT > 16 sec, aPTT > 32, platelet < 50,000/cumm

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 0.5% marcaine 20ml<br>3 levels ultrasound guided thoracic paravertebral blocks at T5-6, T7-8 and T9-10 (total 0.5% marcaine 20ml) | Drug: 0.5% marcaine 20ml<br>* 3 levels ultrasound guided thoracic paravertebral block at T5-6, T7-8 and T9-10 (total 0.5% marcaine 20ml)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pain score at recovery room both at rest and movement (cough) | All patients at recovery room has mild pain (pain score </= 3) and do not need any rescue analgesic drugs. | Up to 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Distribution of local anesthetic drugs after performing ultrasound guided TPVB at T5-6, T7-8 and T9-10. | Test with cold sensation. | After performing TPVB at 5, 10, 20 and 30 minutes. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
paravertebral block, ultrasound guided
Endoscopic Full Thickness Resection With Laparoscopic Assistance

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the feasibility of endoscopic full-thickness resection with laparoscopic assistance.

Detailed Description
-----------------
The laparoscopic resection with a linear stapler for subepithelial tumors (SET) can lead to excessive resection of healthy tissue of the gastric wall resulting in deformity or stenosis. Attaining a positive surgical margin is also possible. Endoscopic full-thickness resection (EFTR) can be used for tumor resection by direct visualization of the tumor from inside the stomach lumen leading to a free surgical margin with little resection of healthy tissue. In order to overcome current endoscopic technical limitations, we will combine the conventional laparoscopic approach with EFTR.

Official Title
-----------------
Endoscopic Full Thickness Resection With Laparoscopic Assistance, Single Center Single Arm Study

Conditions
-----------------
Gastric Subepithelial Tumor

Intervention / Treatment
-----------------
* Procedure: EFTR with LA


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Gastric subepithelial tumor Invasion of muscularis propria on Endoscopic ultrasound Tumor size 1.5cm-5cm or increasing size during follow-up Exclusion Criteria: Bleeding tendency, Inappropriate condition for surgery with general anesthesia Refuse to be enrolled to study

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: EFTR with LA<br>(Endoscopic full-thickness resection with laparoscopic assistance) | Procedure: EFTR with LA<br>* (Endoscopic full-thickness resection with laparoscopic assistance)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| En-bloc resection and successful closure | successful En-bloc resection of subepithelial tumor and successful closure of resection site by Endoscopic full-thickness resection with laparoscopic assistance. | 3 months after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of troche |  | during surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Endoscopic full-thickness resection, gastric subepithelial tumor, hybrid-NOTES
Patient's and Caregiver's Expectations and Preferences Concerning Art Therapy Activities for Cancer Support

Study Overview
=================
Brief Summary
-----------------
Cancer patients and their caregivers often experience difficulties in coping with the cancer diagnosis and the treatment that follows. Creative art therapy could support cancer patients and their caregivers in coping with these issues by using their creativity and self-expression. The aim of this study for the investigator's research team is to create a clear image of what cancer patients and their caregivers expect of supportive care to help them coping with cancer diagnosis, cancer therapy and life after cancer. This is a prospective, interventional study. Cancer patients and their caregivers will be approached to participate in this study. They will be asked to complete a questionnaire about their satisfaction with the current support they get to help them coping with cancer diagnosis, cancer therapy and life after cancer and whether they would like to participate in an art therapy program, which art therapy forms they would like to participate in, how they would like them to be organized, etc.

Official Title
-----------------
Patient's and Caregiver's Expectations and Preferences Concerning Art Therapy Activities for Cancer Support in Light of Founding an Art Therapy Centre

Conditions
-----------------
Cancer, Psychological Distress

Intervention / Treatment
-----------------
* Other: Questionnaire


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Dutch speaking patients and caregivers Patients and caregivers presenting at the outpatient clinic, including the day-care clinic and follow up visits

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Intervention<br>Patients and caregivers were asked to complete a questionnaire | Other: Questionnaire<br>* Patients and caregivers were asked to complete a questionnaire<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Response rate |  | At study inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Activities of interest assessed by questionnary |  | At study inclusion | 
| Preference on organization of activities evaluated by questionnary |  | At study inclusion | 
| Patient or caregiver characteristics (sex, age, diagnosis) collected by questionnary |  | At study inclusion | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Art therapy, surveys and questionnaires, patient, caregiver
Ultrasound Guided Regional Anesthesia for Acute Injury in Low Resource Settings

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine feasibility, perceived utility and sustainability of training local providers in ultrasound guided regional anesthesia for acute pain management in a limited-resource conflict setting.

Detailed Description
-----------------
To the investigators knowledge, this is the first study of feasibility, perceived utility and sustainability of USRA as a pain management tool in a low-resource conflict setting and is one of the only large studies to date to assess USRA by local providers for emergent pain relief due to injury in patients presenting to an acute care center.

Official Title
-----------------
Feasibility, Perceived Utility and Sustainability of Using Ultrasound-guided Regional Anesthesia by Local Providers in a Limited Resource Conflict Setting

Conditions
-----------------
Pain Management, Acute Injuries

Intervention / Treatment
-----------------
* Procedure: ultrasound guided regional nerve block


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: participants were chosen by hospital administration Exclusion Criteria: only chosen participants were included
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Course participants<br>Physicians, nurses and orthopedic officers who staff the emergency intake and orthopedic procedure area of HEAL hospital, Goma DRC, Black Lion Hospital, Addis Ababa and Kindu General Hospital in Kindu DRC. These participants recorded their nerve block intervention over one year for pain management and assessed patient pain level after 10 cc lidocaine. | Procedure: ultrasound guided regional nerve block<br>* participants were the physicians performing the procedure<br>* Other names: lidocaine 1% and 2%;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Participant perceived utility of ultrasound guided nerve block | Participants filled out a data sheet on each block performed. The participant stated yes/no if a block was found to have positive utility | study start - ongoing (24 months) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Participant course satisfaction | Post course evaluation of course satisfaction and balance of didactic simulation and clinical scanning | at course end (5 days) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
trauma, low resource, conflict setting, ultrasound guided regional anesthesia, acute injuries, pain management, education, ultrasound, emergency department