Interactive Stepping Exercise on Memory

Study Overview
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Brief Summary
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This is a randomized controlled trail. A total of 28 individuals with aMCI will be randomly assigned to either the ISE group or control group. The ISE intervention conducts three times a week for 16 weeks. Outcomes are measured at baseline and after intervention. The primary outcomes are the Chinese version verbal learning test (CVVLT), selective reminding test (SRT), and logic memory test (Wechsler Memory Scale). The secondary outcomes are Montreal Cognitive Assessment (MoCA) for cognitive function, and trail making test Part A & B (TMT-A & B), Stroop test, and 25-item Executive Interview (C-EXIT 25) for executive function.

Official Title
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Effects of Interactive Stepping Exercise on Memory in Adults With Amnestic Mild Cognitive Impairment

Conditions
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Amnestic Mild Cognitive Impairment, Interactive Stepping Exercise, Memory, Cognitive Function, Executive Function

Intervention / Treatment
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* Other: Interactive stepping exercise
* Other: Home exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age≥50 years Complained of memory impairment Chinese Version Verbal Learning Test 10-minute delays ≤ 6 words MMSE score≥24 and CDR score=0.5 Activities of daily living are intact DSM-IV criteria for the diagnosis of dementia is not met Exclusion Criteria: Any significant neurologic disease other than suspected incipient Alzheimer's disease Psychotic features, contraindication of exercise... which could lead to difficulty complying with the protocol

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Interactive stepping exercise group<br> | Other: Interactive stepping exercise<br>* An exercise intervention based on the principle of square stepping exercise<br>|
| Active Comparator: Home exercise group<br> | Other: Home exercise<br>* Home exercise<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Chinese version verbal learning test |  | Change from baseline at 12 week | 
| Selective reminding test |  | Change from baseline at 12 week | 
| Wechsler Memory Scale-III |  | Change from baseline at 12 week | 
| Logic memory test |  | Change from baseline at 12 week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Montreal Cognitive Assessment |  | Change from baseline at 12 week | 
| Trail making test |  | Change from baseline at 12 week | 
| Stroop test |  | Change from baseline at 12 week | 
| Executive Interview |  | Change from baseline at 12 week | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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square stepping exercise, Amnestic mild cognitive impairment, Interactive stepping exercise, memory, cognitive function, executive function