DAPHNE Scale Validation in Frontotemporal Lobar Degeneration

Study Overview
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Brief Summary
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Psycho-behavioral disorders assessment is crucial for the diagnosis and follow-up of patients with frontotemporal degeneration (FTD). DAPHNE scientific staff have therefore developed a quantification and follow-up scale specifically dedicated to patients with FTD in current clinical practice. This scale is called DAPHNE to Disinhibition, Apathy, Perseveration, Hyper orality, Negligence and loss of Empathy.

Detailed Description
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Psycho-behavioral disorders assessment is crucial for the diagnosis and follow-up of patients with frontotemporal degeneration (FTD). DAPHNE scientific staff have therefore developed a quantification and follow-up scale specifically dedicated to patients with FTD in current clinical practice. This scale is called DAPHNE to Disinhibition, Apathy, Perseveration, Hyperorality, Negligence and loss of Empathy. This study aims to validate this scale. This validation will include methodological steps required to develop a new clinical tool, by studying internal consistency, loyalty, and concurrent validity in comparison with validated existing tools. Complementarily, sensitivity and specificity will be assessed via a control population including patients with Alzheimer's disease, , progressive supranuclear palsy and bipolar disorder with cognitive disorders.

Official Title
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Psycho-behavioral Disorders in Frontotemporal Lobar Degeneration: Validation of a Quantification and Follow-up Scale

Conditions
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Frontotemporal Lobar Degeneration

Intervention / Treatment
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* Other: Psycho-behavioural assessment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Group 1: Patients with FTD according Neary (1998) and Raskowsky (2011) diagnostic criteria. Mini-Mental State Examination ≥ 18 Consent Group 2 Control: Patients with Alzheimer's disease (MacKahn, 2011), patients with supranuclear palsy (Litvan, 1996) and patients with bipolar disorder with cognitive disorders. criteria. Mini-Mental State Examination ≥ 18 Consent Exclusion Criteria: Minor patient

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Fronto-temporal lobar degeneration<br>DAPHNE score building and internal validation through Fronto-temporal lobar degeneration patients. | Other: Psycho-behavioural assessment<br>* DAPHNE Scale<br>|
| Control<br>External validation of DAPHNE score among patients with Alzheimer's disease, progressive supranuclear palsy and bipolar disorder with cognitive disorders. | Other: Psycho-behavioural assessment<br>* DAPHNE Scale<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Internal validation of DAPHNE Score | Face validity - Structural validity - Convergent Validity - Known-groups validity - Responses consistency - Reliability | Baseline |