Post-Myocardial Infarction Patients in Santa Catarina, Brazil - Catarina Heart Study

Study Overview
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Brief Summary
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Prospective cohort evaluating patients in the State of Santa Catarina (Brazil) with the diagnosis of the first acute myocardial infarction from July 2016 until December 2020.

Official Title
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Post-Myocardial Infarction Patients in Santa Catarina, Brazil: a Prospective Cohort Study - Catarina Heart Study

Conditions
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Myocardial Infarction

Intervention / Treatment
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* Other: Myocardial Infarction


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age over 18 years; Presence of precordial pain suggestive of acute myocardial infarction associated with electrocardiogram with new ST segment elevation in two contiguous leads with limits: ≥0.1 mv in all leads other than leads V2-V3 where the following limits apply : ≥0.2 mv in Men ≥40 years; ≥0.25 mV in men <40 years, or ≥ 0.15 mV in women or presence of precordial pain suggestive of acute myocardial infarction associated with elevation of troponin I or CK-MB above the 99th percentile of the upper reference limit Exclusion Criteria: Previous acute myocardial infarction; Disagreement with the Terms of Informed Consent.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Myocardial Infarction<br>Patients with first myocardial Infarction | Other: Myocardial Infarction<br>* Observational study of myocardial Infarction patients<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MACE in 1 year |  | Major cardiovascular events - MACE (cardiovascular death, nonfatal infarction, unstable angina or stroke) in 1 year | 
| MACE in 30 days |  | Major cardiovascular events - MACE (cardiovascular death, nonfatal infarction, unstable angina or stroke) in 30 days | 
| Death in 1 year |  | Death incidence in 1 year | 
| Death in 30 days |  | Death incidence in 30 days | 
| Restenosis in 1 year |  | Restenosis incidence in 1 year | 
| Restenosis in 30 days |  | Restenosis incidence in 30 days | 
| Intrastent thrombosis in 1 year |  | Intrastent thrombosis incidence in 30 days | 
| Intrastent thrombosis in 30 days |  | Intrastent thrombosis incidence in 30 days | 
| Cardiovascular death in 1 year |  | Cardiovascular death incidence in 1 year | 
| Cardiovascular death in 30 days |  | Cardiovascular death incidence in 30 days | 
| Nonfatal infarction in 1 year |  | Nonfatal infarction incidence in 1 year | 
| Nonfatal infarction in 30 days |  | Nonfatal infarction incidence in 30 days | 
| Unstable angina in 1 year |  | Unstable angina incidence in 1 year | 
| Unstable angina in 30 days |  | Unstable angina incidence in 30 days | 
| Stroke in 1 year |  | Stroke incidence in 1 year | 
| Stroke in 30 days |  | Stroke incidence in 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Epidemiological profile |  | Epidemiological profile of hospitalized patients with infarction in Santa Catarina at the admission | 
| Fish consumption | Fish consumption at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction | Fish consumption at admission | 
| Red meat consumption | Read meat consumption at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction | Red meat consumption at admission | 
| Chocolate consumption | Red meat consumption at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction | Chocolate consumption at admission | 
| Caffeine consumption | Caffeine consumption at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction | Caffeine consumption at admission | 
| Alcoholic beverages consumption | Alcoholic beverages consumption at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction | Alcoholic beverages consumption at admission | 
| Illegal drugs consumption | Illegal drugs consumption at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction | Illegal drugs consumption at admission | 
| Cognitive level | Cognitive level (evaluated with Mini-Mental State Examination) at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction syndromes and infarction | Cognitive level at admission | 
| Religiosity | Religiosity (evaluated with Duke University Religion Index) at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction | Religiosity at admission | 
| Pre-infarct physical activity | Pre-infarct (evaluated with Baecke Questionnaire) physical activity at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction | Pre-infarct physical activity at admission | 
| Depression | Depression (evaluated with PHQ-9: Patient Health Questionnaire-9) at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction | Depression at admission | 
| Syntax score | Syntax score at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction | Syntax score at admission | 
| TIMI frame count | TIMI frame count in patients with primary angioplasty at admission its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction | TIMI frame count in patients with primary angioplasty at admission | 
| Ventricular function post-infarction | Ventricular function (ventricular ejection fraction), its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction | Ventricular function post-infarction (evaluated within 72 hours of admission) | 
| Hospitalization in 1 year |  | Hospitalization incidence in 1 year | 
| Hospitalization in 30 days |  | Hospitalization incidence in 30 days | 
| Bleeding in 1 year |  | Bleeding incidence in 1 year | 
| Bleeding in 30 days |  | Bleeding incidence in 30 days | 
| Hematocrit and hemoglobin |  | Hematocrit and hemoglobin at the admission | 
| Hematocrit and hemoglobin in 72 hours |  | Hematocrit and hemoglobin in 72 hours | 
| Red Cell Distribution Width (RDW) |  | Red Cell Distribution Width (RDW) at admission | 
| Red Cell Distribution Width (RDW) |  | Red Cell Distribution Width (RDW) in 72 hours | 
| Leukocytes |  | Leukocytes at admission | 
| Leukocytes |  | Leukocytes in 72 hours | 
| Creatinine |  | Creatinine at admission | 
| Creatinine |  | Creatinine in 72 hours | 
| Troponin levels |  | Troponin levels at admission | 
| Troponin levels |  | Troponin levels in 72 hours | 
| Cholesterol levels |  | Cholesterol levels at admission | 
| Cholesterol levels |  | Cholesterol levels in 72 hours | 
| C-reactive protein |  | C-reactive protein at admission | 
| C-reactive protein |  | C-reactive protein in 72 hours | 
| CHA2DS2-VASc Score | CHA2DS2-VASc Score, its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction | CHA2DS2-VASc Score at admission |