Effect of Quercetin on Prophylaxis and Treatment of COVID-19

Study Overview
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Brief Summary
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Novel Coronavirus is defined to be the cause of COVID-19, recently. It's known that COVID-19 goes with excessive immune reaction of human body in severe cases. The investigators hypothesize that quercetin, as a strong scavenger and anti-inflammatory agent, can be effective on both prophylaxis and treatment of COVID-19 cases. Therefore, the aim of this study to evaluate the possible role of quercetin on prophylaxis and treatment of COVID-19.

Detailed Description
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Novel Coronavirus is defined to be the cause of COVID-19, recently. It's known that COVID-19 goes with excessive immune reaction of human body in severe cases. Quercetin is reported to be effective on treatment and prophylaxis of other SARS like coronavirus infections, as a strong antioxidant and scavenger flavonoid without any adverse events. Upon this data, the investigators hypothesize that quercetin can be effective on both prophylaxis and treatment of COVID-19 cases. Therefore, the aim of this study to evaluate the possible role of quercetin on prophylaxis and treatment of COVID-19.

Official Title
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The Possible Effect of Quercetin on Prophylaxis and Treatment of COVID-19

Conditions
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COVID-19

Intervention / Treatment
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* Dietary Supplement: Quercetin Prophylaxis
* Dietary Supplement: Quercetin Treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: moderate-high risk for COVID-19 obtained informed consent Exclusion Criteria: declined to participate genetic/chromosomal abnormalities any kind of sensitivity or allergy for quercetin history of previous hypersensitivity with quercetin

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: non-quercetin group<br>Participants, who accept to enroll the study without having quercetin prophylaxis and who do not have a history of COVID-19, will be in this group. | |
| Active Comparator: quercetin prophylaxis group<br>Participants, who takes a daily dose of 500mg quercetin and who not have a history of COVID-19, will be in this group. | Dietary Supplement: Quercetin Prophylaxis<br>* a daily dose of quercetin (500mg) will be taken by non-COVID-19 intervention group 1<br>|
| Active Comparator: quercetin treatment group<br>Participants, who takes a daily dose of 1000mg quercetin and who are proven cases for COVID-19, will be in this group. | Dietary Supplement: Quercetin Treatment<br>* a daily dose of quercetin (1000mg) will be taken by proven COVID-19 cases intervention group 2<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of COVID-19 calculated using a questionnaire | Prevalence of COVID-19 in prophylaxis and sham group will be calculated using a questionnaire including hospital records | 3 months | 
| Standardized Mortality rate | Mortality rate will be compared between two groups | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Morbidity rate | Morbidity rates besides recovery rates from COVID-19 will be documented | 3 months |