Urosepsis in Patients With Urinary Tract Calculi Receiving Surgical Intervention

Study Overview
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Brief Summary
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Urosepsis is one of major cause of the overall sepsis leading to high morbidity and mortality, which commonly resulted from urinary tract calculi. The investigator aim to identified the incidence and risk factors of urosepsis in the patients with urinary tract calculi underwent surgical intervention in tertiary-care university hospital.

Detailed Description
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Sepsis is one of the leading cause of death of hospitalized patients in Thailand. Urosepsis or sepsis which originate from urinary tract infection was reported around 9-31% of the overall sepsis syndrome. Urinary tract calculi requiring surgical procedure was reported as a common cause of urinary tract infection. Therefore, the investigators aimed to identified the incidence and risk factors of urosepsis in the patients with urinary tract calculi underwent surgical intervention in tertiary-care university hospital. Moreover, the patients with sepsis syndrome will be suffered from many complications such as acute respiratory distress syndrome, acute kidney injury, etc. Currently, there were many early waring scores to predict the risk of complications to help promptly treatment and decrease the severity. The investigator would like to compare the systemic inflammatory response syndrome (SIRS) criteria,Modified Early Warning Score (MEWS) and Quick Sequential Organ Failure Assessment (qSOFA) score to the prediction of postoperative complications in this group of patients. The last primary objective of this study is to follow the course of the patients diagnosed as urosepsis if they had been treated properly according to the sepsis bundle guideline and their outcome.

Official Title
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Incidence and Risk Factors of Urosepsis in Patients With Urinary Tract Calculi Receiving Surgical Intervention

Conditions
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Urosepsis, Urinary Tract Stone

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Adult patients with urinary tract calculi requiring surgical procedure Exclusion Criteria: - Incomplete data

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of urosepsis diagnosis | According to urine exam and SIRS criteria of sepsis | 7 days after surgery | 
| Date of urosepsis diagnosis | date of diagnosis of urosepsis | 7 days after surgery | 
| Mortality rate | Number of deceased patient after surgery | 30 days after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of stay | hospital stay intensive care unit stay | 7 days after surgery | 
| Rate of intensive care unit admission | Number of patients required ICU admission | 7 days after surgery | 
| Rate of blood transfusion | Amount of blood transfusion in unit during admission | 7 days after surgery | 
| Rate of mechanical ventilation requirement | Number of patient required mechanical ventilation support | 7 days after surgery | 
| Rate of re-operation | Number of patients require second procedure at the same admission | 7 days after surgery | 
| Prevalence of acute kidney injury | According to KDIGO criteria | 30 days after surgery | 
| Rate of renal replacement therapy requirement | Number of patients require renal replacement therapy | 30 days after surgery |