Efficacy of Low Dose Sugammadex in Reversal of NMB in Laparoscopic Barbaric Surgery

Study Overview
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Brief Summary
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the investigators aimed to compare the efficacy and safety of sugammadex at doses of 1.5, 2, and 4 mg/ kg for the reversal of moderate rocuronium-induced neuromuscular blockade in laparoscopic bariatric surgery.

Detailed Description
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Patients were randomly assigned using a randomization-computer program into three groups according to the dose of sugammadex administrated (according to the IBW after T2 of TOF): Group I: patients were given 1.5 mg / kg. Group II: patients were given 2 mg / kg. Group III: patients were given 4 mg / kg.

Official Title
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Comparison of Three Different Doses Sugammadex Based on Ideal Body Weight for Reversal of Moderate Rocuronium-induced Neuromuscular Blockade in Laparoscopic Bariatric Surgery.

Conditions
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Bariatric Patients

Intervention / Treatment
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* Drug: sugammadex reversal of neuromuscular blockade


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: morbidly obese patients of both sex (BMI > 40 kg.m-2) scheduled for elective laparoscopic bariatric surgery (gastric bypass or sleeve surgery) under general anesthesia using rocuronium for tracheal intubation and maintenance of NMB aged between 18 and 60 years and classified as ASA II - III Exclusion Criteria: liver and renal dysfunction, disabling neuropsychiatric disorders, history of stroke, brain trauma in the last 12 months hypersensitivity to anesthetics, history of myocardial infarction, congestive heart failure difficult tracheal intubation, and known or suspected disorder affecting NMB.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: group 1<br>patients were given 1.5 mg / kg. of sugammadex administrated (according to the IBW after T2 of TOF) | Drug: sugammadex reversal of neuromuscular blockade<br> <br> |
| Active Comparator: group II<br>patients were given 2 mg / kg. of sugammadex administrated (according to the IBW after T2 of TOF) | Drug: sugammadex reversal of neuromuscular blockade<br> <br> |
| Active Comparator: group III<br>patients were given 4 mg / kg. of sugammadex administrated (according to the IBW after T2 of TOF) | Drug: sugammadex reversal of neuromuscular blockade<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| sugammadex time following a dose of 1.5 mg / kg of sugammadex according to IBW in comparison to 2, and 4 mg / kg, |  | 2 hrs | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| extubation time |  | 2 hrs |