Ventricular Arrhythmia After Myocarditis in Sportsman

Study Overview
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Brief Summary
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The study aims to assess the prevalence of ventricular rhythmic disorder after an acute myocarditis in sportsmen. 50 patients with acute myocarditis, confirmed by MRI, will be assessed by ECG Holter and Treadmill stress test during a 1-year follow-up.

Official Title
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Quantification of Ventricular Arrhythmia After Myocarditis in Sportsman

Conditions
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Myocarditis Acute, Ventricular Arrythmia

Intervention / Treatment
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* Diagnostic Test: Treadmill Stress test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: acute myocarditis, diagnosed on the association of (a) recent viral infection (upper airway, gastro-intestinal) , (b) troponin increase, and (c) chest pain AND myocarditis confirmed by cardiac magnetic resonance 2 out of 3 Lake Louise criteria, either T2 hypersignal, early enhancement or late gadolinium enhancement. regular physical activity, recreational or competitive: >=4 hours weekly written informed consent Exclusion Criteria: coronary artery disease acute inflammatory cardiomyopathy (sarcoidosis, fulminant myocarditis, Tako Tsubo, eosinophilic myocarditis, Lyme disease) history of myocarditis contra-indication to cardiac MRI patient unable to perform a treadmill stress test

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Treadmill Stress test|Ventricular arrhythmia will be assessed by ECG Holter and during treadmill stress test, both being performed 3 months and 1 year after acute myocarditis|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complex ventricular arrhythmia | any ventricular tachycardia (triplet or more), ventricular fibrillation (observed on ECG Holter or during stress test) | any timepoint: 3 month and/or 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| In-hospital ventricular arrhythmia | any ventricular tachycardia (triplet or more), ventricular fibrillation, recorded on ECG monitoring | up to 2 weeks after admission | 
| Left Ventricular remodeling | Change in LV volumes during time | between baseline and 3 months | 
| Left ventricular fibrosis | Change in interstitial fibrosis by T1 mapping cardiac magnetic resonnance | between baseline and 3 months | 
| Major adverse cardio vascular event | CV death, sudden cardiac death, cardiac graft or haemodynamic support, hospitalisation for heart failure, new event of myocarditis | up to 2 years after inclusion | 
| return to physical activity | defined as at least 75% of exercising time (in hours per week) | up to 2 years after inclusion |