The Effect of Periradial Injection of Papaverine Versus Nitroglycerine on Radial Artery Diameter

Study Overview
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Brief Summary
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Compare the effect of periradial injection of papaverine versus nitroglycerine on radial artery diamter before cannulation of it in cardiac surgery.

Detailed Description
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we want in this study to facilitate radial artery canulation and decrease the number of attemps of puncture which may lead to disappearance of the pulse. The aim of this study is to compare the effect of adding papaverine to local anesthetic xylocaine versus adding nitroglycerine to it on the diameter and palpability of radial artery and if perioperative spasm will decrease significantly with one of these methods.

Official Title
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The Effect of Periradial Injection of Papaverine Versus Nitroglycerine on Radial Artery Diameter Prior to Cannulation.

Conditions
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Radial Artery Injury Prevetion

Intervention / Treatment
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* Drug: papaverine
* Drug: nitroglycerine
* Drug: xlyocaine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Patients who will be included in the study are those scheduled for elective cardiac surgery who are hemodynamically stable. Exclusion Criteria: Any patient with negative modified Allen test, atrioventricular block, glaucoma, altered liver function, unstable hemodynamics, emergency surgeries, and peripheral vascular disease.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: papaverine<br> | Drug: papaverine<br>* periradial injection of one of three drugs prior to cannulation of radial artery by 20 minutes and mesure the diamter of it by ultrasound<br>|
| Active Comparator: nitroglycerine<br> | Drug: nitroglycerine<br>* periradial injection of one of three drugs prior to cannulation of radial artery by 20 minutes and mesure the diamter of it by ultrasound<br>|
| Placebo Comparator: xlyocaine<br> | Drug: xlyocaine<br>* periradial injection of one of three drugs prior to cannulation of radial artery by 20 minutes and mesure the diamter of it by ultrasound<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| diameter of radial artery | after periradial injection of one of the drugs we will feel the radial artery pulse and record if there is a change in the palpatory score and mesure the diameter of the radial artery by ultrasound in cardiac surgery patients | 20 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| spasm of radial artery | detect if there is postoperative spasm of radial artery | 24 hours |