Hypertriglyceridemia Associated Acute Pancreatitis in Intensive Care Unit and Therapeutic Plasmapheresis

Study Overview
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Brief Summary
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Acute pancreatitis (AP) is a one of the potentially life-threatening complication of severe hypertriglyceridemia (HTG), with mortality around to 30%. HTG-associated PA and their complications management has to be the same as the other pancreatitis, but they are associated with the worse clinical outcomes. Triglycerides levels are correlated with the risk of pancreatitis and severity. Therapeutic plasma exchange (TPE) could provide positive effects in reducing triglyceridemia plasma levels during the acute phase of HTG-AP, and in prevention of recurrence. There is currently no difference about mortality in studies. Some authors have recommended its use only in severe HTG-AP and have precised the need of early initiation to have positive results. Despite such promising findings from studies, the effects of therapeutic plasma exchange on HTG-associated PA have never been specifically assessed and its benefits in critically ill patients with AP remains uncertain.

Official Title
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Hypertriglyceridemia Associated Acute Pancreatitis in Intensive Care Unit and Therapeutic Plasmapheresis: a Multicenter Retrospective Study

Conditions
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Pancreatitis, Hypertriglyceridemia

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age > 18 years Admission in ICU for acute pancreatitis associated with HTG Exclusion Criteria : Patient without norepinephrine or missing data. Acute pancreatitis without HTG Patient already include in this study Patient opposed to use of his data

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| severe acute pancreatitis<br>Patients 18 years of age or older admitted to intensive care or resuscitation for severe acute pancreatitis (AP) with hypertriglyceridemia (HTG) | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality at Day 28 | Assess the factors on admission associated with the prognosis of patients admitted in ICU for HTG-associated PA. Factors associated with death at D28 will be considered individually for entry into a multivariate model. The following variables of interest will be tested in the model: SOFA score, triglyceride level at admission, obesity. | Day 28 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of hospitalization | Describe length of stay in ICU and on hospital for patients admitted in ICU for HTG-associated PA | Day 28 | 
| Use of organ support | Describe use of organ supports (vasopressors, extra-renal dialysis and mechanical ventilation) | Day 28 | 
| Assess benefit of plasmapheresis | Assess benefit of plasmapheresis for patients admitted in ICU for HTG-associated PA | Day 28 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ICU