Korean Stroke Cohort for Functioning and Rehabilitation-II

Study Overview
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Brief Summary
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Korean Stroke Cohort for functioning and rehabilitation (KOSCO)-II is a large, multi-centre prospective cohort study for all acute first-ever stroke patients admitted to participating hospitals in nine distinct areas of Korea. This study is designed as a 10-year, longitudinal follow-up investigating the residual disabilities, activity limitations, and quality of life issues arising in patients suffering from first-ever stroke as previous similar stroke cohort with KOSCO. The main objectives of this study are to identify and compare the factors that influence residual disability and long-term quality of life in first-ever acute stroke patients with KOSCO. The secondary objectives of this study are to determine and compare the risk of mortality and recurrent vascular events in first-ever acute stroke patients with KOSCO. Investigators will investigate longitudinal health behaviors and patterns of healthcare utilization, including stroke rehabilitation care. Investigators will also investigate the long-term health status, mood, and quality of life in stroke patient caregivers. In addition, investigators will identify baseline and ongoing characteristics that are associated with secondary outcomes.

Official Title
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Korean Stroke Cohort for Functioning and Rehabilitation-II

Conditions
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Stroke

Intervention / Treatment
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* Other: open


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: First-ever acute stroke (ischemic stroke or intracerebral hemorrhage) with corresponding lesion and/or evidence of acute arterial occlusion on CT (A)- or MRI/A-scan. Age ≥ 19 years at onset of stroke. Onset of symptoms within seven days prior to inclusion. Exclusion Criteria: Transient ischemic attack. History of stroke. Traumatic intracerebral hemorrhage. Not Korean.

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: open|open|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Korean modified Barthel Index | measurement for activities of daily living Minimum: 0, Maximum: 100 Higher scores means a better. | 3 months, 6 months, 12 months, 18 months, 24 months, 36 months, 48 months, 60 months, 72 months, 84 months, 96 months, 108 months after stroke onset. | 
| Change in Euro Quality of Life-5 Dimensions measurement for quality of life | measurement for quality of life Minimum: 0, Maximum: 1 Higher scores means a better. | 3 months, 6 months, 12 months, 18 months, 24 months, 36 months, 48 months, 60 months, 72 months, 84 months, 96 months, 108 months after stroke onset. | 
| Change in Functional Independence Measurement | measurement for activities of daily living Minimum: 0, Maximum: 126 Higher scores means a better. | 3 months, 6 months, 12 months, 18 months, 24 months, 36 months, 48 months, 60 months, 72 months, 84 months, 96 months, 108 months after stroke onset. | 
| Change in Korean Mini-Mental State Examination | measurement for language function Minimum: 0, Maximum: 30 Higher scores means a better. | 7 days, 3 months, 6 months, 12 months, 18 months, 24 months, 36 months, 48 months, 60 months, 72 months, 84 months, 96 months, 108 months after stroke onset. | 
| Change in Korean Version of Frenchay Aphasia Screening Test | measurement for language function Minimum: 0, Maximum: 30 Higher scores means a better. | 7 days, 3 months, 6 months, 12 months, 18 months, 24 months, 36 months, 48 months, 60 months, 72 months, 84 months, 96 months, 108 months after stroke onset. | 
| Change in modified Rankin Scale | Measurement for disability. Range of total score 0 to 6. 0 is no disability at all and 6 is death. Therefore, greater value means worse functional status | 7 days, 3 months, 6 months, 12 months, 18 months, 24 months, 36 months, 48 months, 60 months, 72 months, 84 months, 96 months, 108 months after stroke onset | 
| Change in American Speech-Language-Hearing Association National Outcome Measurement System Swallowing Scale | Measurement for swallowing function. Range of scale is 0 to 7, and greater value means better function. For example, 7 means no swallowing difficulty at all. | 7 days, 3 months, 6 months, 12 months, 18 months, 24 months, 36 months, 48 months, 60 months, 72 months, 84 months, 96 months, 108 months after stroke onset | 
| Change in Geriatric depression scale-short form | measurement for depression. The scale is 0 to 15. 0 is normal whereas 15 indicates severe depression. Minimum: 0, Maximum: 15. Lower scores means a better. | 3 months, 6 months, 12 months, 18 months, 24 months, 36 months, 48 months, 60 months, 72 months, 84 months, 96 months, 108 months after stroke onset | 
| Change in Functional Ambulatory Category | measurement for gait function Minimum: 0, Maximum: 5 Higher scores means a better. | 7 days, 3 months, 6 months, 12 months, 18 months, 24 months, 36 months, 48 months, 60 months, 72 months, 84 months, 96 months, 108 months after stroke onset | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Stroke, Disability, Function, Rehabilitation, Burden