Penicillin Skin Testing in Patients With History of Allergic Reactions to Betalactams

Study Overview
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Brief Summary
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This study aims to compare the readings of skin testing results in patients with suspected penicillin allergy between in-house penicillin test preparation and commercial available penicillin testing kit.

Detailed Description
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The results of skin test with immediate reading will be compared between alkali-treated penicillin G and DAP reagents from Diater

Official Title
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The Comparative Results of Penicillin Testing in Patients With History of Allergic Reactions to Betalactams Between Using In-house Penicillin Test Preparation and Commercial Available Penicillin Testing Kit

Conditions
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Penicillin Allergy

Intervention / Treatment
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* Procedure: Immediate skin test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with history of hypersensitivity reactions to betalactams; penicillin, aminopenicillins, and cephalosporins 15-65 years of age Exclusion Criteria: On antihistamine/ cannot discontinue antihistamine before the test Having asthma exacerbation Being pregnant Suffering from severe systemic disease/ in bad health

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: In-house penicillin testing preparation<br>In-house penicillin testing prepared from alkali-treated penicillin G | Procedure: Immediate skin test<br>* Intradermal test with immediate reading<br>* Other names: Intradermal test with reading at 15 minutes after injection;|
| Active Comparator: Commercial penicillin test kit<br>Commercial penicillin test kit order from Diater company | Procedure: Immediate skin test<br>* Intradermal test with immediate reading<br>* Other names: Intradermal test with reading at 15 minutes after injection;|
| Active Comparator: Penicillin G Sodium<br>Penicillin G Sodium from routine clinical use | Procedure: Immediate skin test<br>* Intradermal test with immediate reading<br>* Other names: Intradermal test with reading at 15 minutes after injection;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The skin testing results of in-house penicillin skin test and Penicillin G Sodium compared to commercial penicillin testing kit |  | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical correlation and side effects |  | 1 year | 
| Correlations between Penicillin skin test result with specific IgE and/or basophil activation test |  | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Penicillin, Beta-Lactams, Allergy, Hypersensitivity