Circadian Rhythms and Sleep in Familial DSPS and ASPS

Study Overview
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Brief Summary
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The purpose of this study is to determine the properties of circadian rhythms and sleep propensity in familial advanced and delayed sleep phase syndrome (DSPS).

Detailed Description
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BACKGROUND: Tremendous progress in the past few years has led to the identification of several circadian clock genes. This now makes it possible to determine how alterations of human circadian clock genes and their expression could lead to differences in circadian and sleep/wake cycle phenotypes. Of particular interest for understanding genetics of the human circadian system are individuals with sleep phase disorders, such as DSPS and advanced sleep phase syndrome (ASPS), because recent studies indicate a genetic basis for these disorders. While it is assumed that both ASPS and DSPS are disorders of circadian timing, little is known about how the circadian clock system, or its interaction with sleep processes, are affected in these individuals. DESIGN NARRATIVE: Participants will complete questionnaires and actigraphy to determine sleep patterns and quality.

Official Title
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Circadian Rhythms and Sleep in Familial Delayed Sleep Phase Syndrome (DSPS) and Advanced Sleep Phase Syndrome (ASPS)

Conditions
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Circadian Rhythm Sleep Disorder

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria for ASPS Participants: Morning type score on the Horne-Ostberg questionnaire Advanced melatonin onset Inclusion Criteria for DSPS Participants: Evening type score on the Horne-Ostberg questionnaire Delayed melatonin onset Inclusion Criteria for Controls: A stable sleep/wake pattern with a normal phase relationship to the environment and no history of sleep disorders Exclusion Criteria for all subjects: Sleep disorder, other than DSPS or ASPS, as assessed by the Pittsburgh Sleep Quality Index and/or by polysomnogram History of cognitive or other neurological disorders History of Diagnostic and Statistical Manual-IV criteria for any major psychiatric disorder, alcohol or substance abuse Abnormal mood as assessed by the Hamilton Depression Scale History of, or concurrent, unstable or serious medical illness Current use of psychoactive medications, including antidepressants, anxiolytics, neuroleptics, anticonvulsants, hypnotics, and stimulant medications Shift work Having a daily caffeine intake greater than 4 cups per day Smoking Travel across more than 2 time zones within 90 days of the study Pregnancy or the desire to become pregnant during the study period

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>People with delayed sleep phase syndrome (DSPS). | |
| 2<br>People with advanced sleep phase syndrome (ASPS). | |
| 3<br>Control group (people with intermediate sleep patterns). | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sleep | Assessment of sleep parameters | 1 night | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Circadian Timing | Assessment of circadian activity profiles | 3 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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circadian, advanced sleep phase, delayed sleep phase