Use of CBCT-based Tooth Replica in Tooth Autotransplantation to Improve the Outcome of Tooth Replacement in Children

Study Overview
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Brief Summary
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The aim of this study lies in comparing the outcome of the proposed technique in a large sample size group to the outcome of the conventional tooth autotransplantation method and to provide sufficient evidence for improving the long-term success rate of the tooth autotransplantation procedure.

Official Title
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Use of Stereolithographic Model in Tooth Autotransplantation and Periodontal Ligament Stem Cells for Pulp Revascularization and Reinnervation to Increase the Success Rate for Tooth Replacement in Children

Conditions
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Increase Success Rate of Tooth Transplantation

Intervention / Treatment
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* Other: stereolithography tooth replica


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The subjects will be divided in two groups according to different surgical protocols. Pediatric subjects (age between 9-18 years) treated with the CBCT-based replica procedure (prospective approach). Pediatric subjects (N=50) that missed their teeth due to agenesis or lost their permanent teeth due to trauma, caries, and endodontic failure and referred to dentistry department for replacement of the missing tooth by means of tooth autotransplantation. Pediatric subjects (age between 9-18 years) treated with the conventional method (prospective and retrospective). Pediatric subjects (N=50) that missed their teeth due to agenesis or lost their permanent teeth due to trauma, caries, and endodontic failure and referred to dentistry department for replacement of the missing tooth by means of tooth autotransplantation. A matched control patient will be selected with the focus on a very similar surgical challenge, based on age, gender and a matching donor tooth with the same stage of root development and host bed. Exclusion Criteria: Potential participants (case and control) will be excluded if follow-up data are missing for the one-year follow-up.

Ages Eligible for Study
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Minimum Age: 9 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: stereolithography tooth replica<br>stereolithographic tooth replica used as a guide for tooth autotransplantation decreases extra-alveolar time and reduces trauma to periodontal ligament tissue therefore increasing the success rate after transplantation | Other: stereolithography tooth replica<br>* Tooth replica will be made and used for preparing the receiving tooth socket during autotransplantation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| success rate |  | 5 years | 
| survival rate |  | 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Tooth autotransplantation, stereolithography tooth replica, CBCT, Outcome