Wound-healing Improvement by Resurfacing Split-Thickness Skin Donor Sites With Thin Split-thickness Grafting

Study Overview
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Brief Summary
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Split-thickness skin grafting remains fundamental treatment of patients with deep burns and other traumatic injuries. However, the split-thickness skin graft (STSG) donor site dressing has been controversial until now. Our study here aimed to assess patient comfort and wound-healing efficacy with the application of thin split-thickness grafting on STSG donor sites.

Detailed Description
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Background：Split-thickness skin grafting remains fundamental treatment of patients with deep burns and other traumatic injuries. However, the split-thickness skin graft (STSG) donor site dressing has been controversial until now. Our study here aimed to assess patient comfort and wound-healing efficacy with the application of thin split-thickness grafting on STSG donor sites. Methods: 192 consecutive patients undergoing split-thickness skin grafting were included in the study and the participants were randomly divided into three groups: Group A was regrafted with thin STSG, while, Group B and Group C were covered with the occlusive hydrocellular dressing and paraffin gauze, respectively. The three groups were compared regarding to the time of epithelialization, pain sensed by the patients and the scar formation.

Official Title
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Wound-healing Improvement by Resurfacing Split-Thickness Skin Donor Sites With Thin Split-thickness Grafting

Conditions
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Skin Graft Disorder, Disorder of Skin Donor Site, Wound Healing Disturbance of

Intervention / Treatment
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* Procedure: regrafted with thin split-thickness skin graft
* Procedure: covered with the occlusive hydrocellular dressing
* Procedure: covered with paraffin gauze


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients who continuously received an STSG from January 2002 to December 2010 in Department of Burn and Plastic Surgery, Tangdu Hospital, Fourth Military Medical University Exclusion Criteria: The patients who were significant psychiatric, hypersensitive to silver, and not be followed up were excluded

Ages Eligible for Study
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Minimum Age: 5 Years
Maximum Age: 56 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| the treatment group A<br>The people in treatment group were regrafted with thin split-thickness skin graft | Procedure: regrafted with thin split-thickness skin graft<br>* Group A (the treatment group) were regrafted with thin split-thickness skin graft<br>|
| the control group B<br>The group B covered with the occlusive hydrocellular dressing (Allevyn Adhesive, Smith & Nephew) | Procedure: covered with the occlusive hydrocellular dressing<br>* group B covered with the occlusive hydrocellular dressing (Allevyn Adhesive, Smith & Nephew)<br>|
| the control group C<br>Group C were covered with paraffin gauze | Procedure: covered with paraffin gauze<br>* Group C covered with paraffin gauze<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The time of epithelialization | The time of epithelialization was observed every 3 days | up to 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain sensed by the patients | Pain sensed by the patients was assessed by Wong-Baker FACES Pain Rating Scale on day 2 and 5 after surgery | up to 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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the split-thickness skin graft （STSG） donor site, regraft, wound healing