Coronary Hemodynamics by Coronary Angiography

Study Overview
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Brief Summary
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Study for developing techniques to evaluate coronary artery hemodynamic profiles by conventional angiography without more dedicated measuring devices.

Detailed Description
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* Methods: Compare TIMI frame count, coronary clearance frame count in baseline/hyperemic coronary angiography with FFR, CFR, IMR and derive correlation, receiver-operating characteristic curve to find new tools estimating coronary hemodynamics by conventional angiography only. A TIMI frame count is measured by counting the angiographic image cine frames during a head of radiocontrast column runs from the entry of left anterior descending artery (LAD) to the distal end. A coronary clearance frame count is measured by counting the angiographic image cine frames during a tail of radiocontrast column runs from the entry of LAD to the distal end. Baseline angiography is performed without any stimulation and hyperemic angiography is performed after intracoronary injection of adenosine 300ug or nicorandiol 2mg. Inclusion criteria Patient who underwent physiologic study using a pressure wire for intermediate coronary lesion after coronary angiography Exclusion criteria ST elevation myocardial infarction Cardiogenic shock Congestive heart failure with pulmonary edema LVEF < 30% Previous history of coronary revascularization Chronic total occlusion 3 vessel disease Target lesion at distal segments or branches

Official Title
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Estimation of Coronary Artery Hemodynamic Profiles Using Cineangiography Technique

Conditions
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Coronary Artery Disease

Intervention / Treatment
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* Drug: Hyperemic stimuli


Participation Criteria
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Eligibility Criteria
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Inclusion criteria Patient who underwent physiologic study using a pressure wire for intermediate coronary lesion after coronary angiography Exclusion criteria ST elevation myocardial infarction Cardiogenic shock Congestive heart failure with pulmonary edema LVEF < 30% Previous history of coronary revascularization Chronic total occlusion 3 vessel disease Target lesion at distal segments or branches

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Interventional Model Description: Patients who underwent coronary angiography and further hyperemic stimui
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Hyperemic stimuli<br>Hyperemic stimuli of coronary flow by adenosine or nicorandil injection | Drug: Hyperemic stimuli<br>* Hyperemic simuli of coronary flow by adenosine or nicorandil injection<br>* Other names: Hyperemia;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| TIMI frame count | frame count between the beginning and end of contrast column head | Imediately after the procedure | 
| Coronary Clearance Frame Count | frame count between the beginning and end of contrast column tail | Imediately after the procedure | 
| Index of microcirculatory resistance | derived from distal coronary pressure by transit time | During the procedure | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fractional flow reserve | measured by pressure wire | During the procedure | 
| Coronary flow reserve | measured by pressure wire by thermodilution technique | During the procedure | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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coronary artery disease, Index of microcirculatory resistance, TIMI frame count, Fractional flow reserve, Coronary flow reserve