Assessing Risk Factors for Radiological Complications After Transforaminal Lumbar Interbody Fusion

Study Overview
=================
Brief Summary
-----------------
This retrospective study is to determine whether age is a risk factor for postoperative complications in patients undergoing transforaminal lumbar interbody fusion; specifically whether the risk (odds) of implant failure and the need for revision surgery increases with age.

Detailed Description
-----------------
Spinal fusion is one of the most commonly performed surgical procedures for the treatment of degenerative spinal disease. Interbody fusion with cages reconstructs the anterior column through disc removal, allowing to maintain proper disc height despite weight bearing, while providing firm fixation of the spinal segments. Transforaminal lumbar interbody fusion (TLIF) has fewer complications and less intraoperative bleeding than posterior lumbar interbody fusion (PLIF). Elderly patients are at high risk for perioperative and postoperative complications after lumbar fusion. This retrospective study is to determine whether age is a risk factor for postoperative complications in patients undergoing transforaminal lumbar interbody fusion; specifically whether the risk (odds) of implant failure and the need for revision surgery increases with age.

Official Title
-----------------
AgeTLIF - Assessing Risk Factors for Radiological Complications After Transforaminal Lumbar Interbody Fusion

Conditions
-----------------
Degenerative Lumbar Spine Diseases

Intervention / Treatment
-----------------
* Other: Data collection (radiological parameters, outcome information) from electronic patient files in hospital data system


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Indications for TLIF surgery (e.g., degenerative disc disease, spondylolisthesis) Existing preoperative upright standing sagittal plane X-ray of lumbar spine with clear visibility of pelvis, sacrum and femoral head Existing preoperative MRI of the lumbar region with clear visibility of different fatty infiltration grade and stenosis degree Complete follow-up at 3 months and 1 year postoperatively, including clinical and radiographic data Exclusion Criteria: Neuromuscular diseases such as Parkinson's disease or multiple sclerosis according to our records Preoperative infection and/or malignancy tumor with involvement of the bony or soft tissue structures of the lumbar spine Presence of a documented consent dissent

Ages Eligible for Study
-----------------
Minimum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Data collection (radiological parameters, outcome information) from electronic patient files in hospital data system|Collection of medical data and medical images (MRI, radiographs) of the lumbar spine and pelvis of patients having received TLIF with degenerative spinal diseases from the years 2015-2020 and statistical analysis of the coded data.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Implant failure | Number of Implant failure (screw loosening, cage subsidence, adjacent level alteration/ degeneration, spondylolisthesis degree, kyphosis of the adjacent intervertebral disc space, reduced height of intervertebral disc space) in relationship to age | one time assessment at baseline | 
| Number of patients needing revision surgery | Number of patients needing revision surgery, in relationship to age | one time assessment at baseline | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Posterior Lumbar Interbody Fusion (PLIF), Transforaminal Lumbar Interbody Fusion (TLIF), Implant Failure, Revision Surgery