Study of the Colonic Carriage of Staphylococcus Aureus in a Prospective Cohort of Patients Undergoing Endoscopic Screening for Digestive Cancer in the University Hospital of Saint-Etienne

Study Overview
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Brief Summary
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Epidemiological study aiming to describe the carriage (nasal, throat, groin, rectal and colonic) of S. aureus in patients without chronic digestive disease who are going to have a colonoscopy for cancer screening. The carriage will be analyzed globally and the similarity of strains isolated from each site will be analyzed using molecular tools. The aim of this study is to better estimate the digestive reservoir of S. aureus to better prevent endogenous infections due to this bacterium.

Official Title
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Study of the Colonic Carriage of Staphylococcus Aureus in a Prospective Cohort of Patients Undergoing Endoscopic Screening for Digestive Cancer in the University Hospital of Saint-Etienne.

Conditions
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STAPHYLOCOCCAL INFECTIONS

Intervention / Treatment
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* Other: Staphylococcus aureus carriage


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient affiliated to French social security Written consent of the patient Patient needing a colonoscopy in the University Hospital of Saint-Etienne, France Exclusion Criteria: Patient who decline to participate to the study Patient in the incapacity to give consent Patient receiving treatment with anticoagulant or antiaggregant platelets Patients with a known haemostatic disorder Pregnant woman Patients with a chronic disease of the gastrointestinal tract Patients receiving long-term corticosteroid Patient receiving anti staphylococcal antibiotics

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patients undergoing a colonoscopy<br>Staphylococcus aureus carriage is measured in nose, throat, colon, rectum and groin | Other: Staphylococcus aureus carriage<br>* nasal, throat, rectal and groin sampling with swabs. Colonic sampling by colonic biopsy<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patient with Staphylococcus aureus colonic carriage | Staphylococcus aureus carriage in the colon is measured by biopsy | Day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patient with similar Staphylococcus aureus strains in the nose and in the rectum | Staphylococcus aureus carriage in the rectum and in the nose is measured by swab culture | Day 1 | 
| Number of patient with Staphylococcus aureus carriage in the nose | Staphylococcus aureus carriage in the nose is measured by swab culture. | Day 1 | 
| Number of patient with Staphylococcus aureus carriage in the throat | Staphylococcus aureus carriage in the throat is measured by swab culture. | Day 1 | 
| Number of patient with Staphylococcus aureus carriage in the groin | Staphylococcus aureus carriage in the groin is measured by swab culture. | Day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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staphylococcus aureus, digestive carriage, mucosal colonization