Bronchial Hyperreactivity in Children With Crohn Disease

Study Overview
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Brief Summary
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Background: Latent pulmonary involvement is described in Crohn Disease(CD). Bronchial hyperreactivity measured by the Methacholine Challenge Test (MCT) has been evaluated in two studies involving mainly adults.Our aim was to determine the frequency of bronchial hyperreactivity in pediatric patients followed and treated for Crohn disease. Methods: Twenty-three children with Crohn disease completed a questionnaire, followed by spirometry, Methacholine Challenge Test (MCT) and determination of Fractional Exhaled NO (FENO). The control group included patients evaluated for functional cough who had negative Methacholine Challenge Test (MCT).

Conditions
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Crohn's Disease

Intervention / Treatment
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* Other: Methacholine Challenge Test
* Other: Fractional Exhaled NO (FENO)
* Other: Blood Test
* Other: PCDAI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Children with Crohn disease Children that can perform lung function tests (MCT) Exclusion Criteria: Upper respiratory tract infection last month Fever or Pneumonia last month Smoking Other chronic diseases Other respiratory diseases

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 25 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Crohn's Patients<br>Random Crohn's Disease Patients that can perform Methacholine Challenge Test (MCT) | Other: Methacholine Challenge Test<br>* Methacholine challenge test to evaluate airway hyperreactivity<br>Other: Fractional Exhaled NO (FENO)<br>* Fractional Exhaled NO to evaluate eosinophilic inflammation<br>Other: Blood Test<br>* Blood Tests (Eosinophil Count)<br>Other: PCDAI<br>* Clinical Evaluation for Pediatric Crohn's Disease Activity Index (PCDAI)<br>|
| Negative MCT<br>Patients evaluated for functional cough who had negative Methacholine Challenge Test (MCT) | Other: Methacholine Challenge Test<br>* Methacholine challenge test to evaluate airway hyperreactivity<br>Other: Fractional Exhaled NO (FENO)<br>* Fractional Exhaled NO to evaluate eosinophilic inflammation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Methacholine challenge test | As assessed by methacholine challenge test with determination of PC20. | 18 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fractional Exhaled NO | Exhaled NO test | Day 1 | 
| Eosinophils count | blood test | Day 1 | 
| Pediatric Crohn's Disease Activity Index (PCDAI) | Clinical Evaluation | Day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Crohn's Disease, Bronchial hyper reactivity, Fractional exhaled NO, Methacholine Challenge Test, Pediatric Crohn's Disease Activity Index, To determine the frequency of bronchial hyperreactivity in pediatric patients followed and treated for Crohn disease