Cystoid Macular Edema After Vitrectomy for Rhegmatogenous Retinal Detachment

Study Overview
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Brief Summary
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To investigate the incidence of cystoid macular edema in eyes with primary rhegmatogenous retinal detachment successfully treated with vitrectomy with gas tamponade, and to evaluate the clinical variables associated with its development.

Detailed Description
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this is an observational, retrospective, multicentre study. The study is based on the retrospective collection of clinical data from patients undergoing gas tamponade vitrectomy for rhegmatogenous retinal detachment. The collection of such data by the investigators will take place at each participating center anonymously. demographics, systemic, and preoperative, intraoperative and post-operative data will be collected The sample size was calculated to obtain approximately 200 patients with cystoid macular edema. Since cystoid macular edema has been detected in 13% of patients after retinal detachment gas vitrectomy, and assuming that this event can occur between 10% and 15% of cases, the study will include at least 2000 cases.

Official Title
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Incidence and Risk Factors for Cystoid Macular Edema After Primary Vitrectomy With Gas Tamponade for Rhegmatogenous Retinal Detachment: a National Study Group

Conditions
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Cystoid Macular Edema

Intervention / Treatment
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* Procedure: vitrectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: primary rhegmatogenous retinal detachment treated with vitrectomy with gas tamponade; follow-up of 3 months or more; age > 18 years ; no previous eye surgery, except cataract surgery performed at least 6 months after hospitalization for retinal detachment; anatomical success, i.e. retinal re-attachment, after a single gas vitrectomy; no other eye surgery during follow-up; availability of optical coherence tomography (OCT) imaging Exclusion Criteria: history of other eye diseases (glaucoma, age-related macular degeneration, uveitis, diabetic retinopathy, maculopathy); macular hole; recurrent retinal detachment; use of silicone oil is used as a tamponading agent

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: vitrectomy|vitrectomy with gas tamponade|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| incidence of cystoid macular edema | cystoid macular edema assessed by OCT (central subfield thickness >310 micron, with presence of intraretinal cystic areas of low reflectivity in OPL) visual acuity | from 1 month up to 6 months after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| factors related to development of macular edema | demographics, systemic and ocular parameters | from 1 month up to 6 months after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cystoid macular edema, rhegmatogenous retinal detachment, vitrectomy, gas tamponade