linjc16/ctgov huggingface dataset:
Prediction of Fluid Responsiveness by NICOM (Non-invasive Cardiac Output Monitoring) in Children With Congenital Heart Disease After Cardiac Surgery

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the ability of fluid responsiveness by stroke volume variation value of NICOM(Noninvasive cardiac output monitor)system during congenital cardiac surgery.

Conditions
-----------------
Fluid Responsiveness

Intervention / Treatment
-----------------
* Other: volume expansion


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: congenital cardiac surgery < 6 years old who were required the evaluation by transesophageal echocardiography Exclusion Criteria: right heart failure supported by more than 2 inotropic agents reduced kidney function any valvar stenosis moderate or severe tricuspid regurgitation single ventricle

Ages Eligible for Study
-----------------
Minimum Age: 1 Day
Maximum Age: 5 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Volume loading<br> | Other: volume expansion<br>* fluid loading of 10 ml/kg colloid or blood product<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| stroke volume index | Volume loading was performed for 20 minutes. Stroke volume measured before and after volume expansion using transesophageal echocardiography. And, stroke volume variation of NICOM monitor was recorded before fluid loading. | before and after volume loading (20 min) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiac index | Cardiac index measured by transesophageal echocardiography and NICOM monitor were compared before and after fluid loading for 20 min. | before and after fluid loading (20 min) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
stroke volume variation,, cardiac output,, fluid responsiveness,, noninvasive cardiac output monitor
Modulation of Circulating Levels of the Ketone Body 3-hydroxybutyrate in Patients With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction: Metabolic Effects. (KETO-HFpEF-Metabolic)

Study Overview
=================
Brief Summary
-----------------
Heart failure (HF) is among the most common causes of death in patients with type 2 diabetes (T2D). Ketones, 3-hydroxybutyrate (3-OHB), have shown to have beneficial effects in patients with hearth failure with reduced ejection fraction. However, this have never been investigated in patients with heart failure with preserved ejection fraction (HFpEF). In this study we would like to investigate the effect of 14 days modulation of circulating ketone body levels on whole body and skeletal metabolism in patients with HFpEF and T2D.

Official Title
-----------------
Modulation of Circulating Levels of the Ketone Body 3-hydroxybutyrate in Patients With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction: Metabolic Effects.

Conditions
-----------------
Heart Failure With Preserved Ejection Fraction, Diabetes Mellitus, Type 2, Ketonemia

Intervention / Treatment
-----------------
* Dietary Supplement: Ketone ester
* Dietary Supplement: Placebo drink


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: (i) Type 2 diabetes, (ii) LVEF > 40 %, (iii) a clinical diagnosis of HFpEF and/or left ventricular hypertrophy (posterior wall thickness > 12 mm) and/or previous myocardial infarction, (iiii) age ≥ 18 years old, and (iv) one of the following criteria (a-d) should be fulfilled: Echocardiographic signs of diastolic dysfunction E/e' > 8 Septal e ́< 7 cm/s and/or lateral e ́ < 10 cm/s Left atrium volume index ≥34 mL/m2 and/or left atrial diameter > 4 cm NT-proBNP > 125 pg/ml. Exclusion Criteria: Insulin treatment, inability to give informed consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Ketone ester<br> | Dietary Supplement: Ketone ester<br>* Commercially available ketone supplement<br>|
| Placebo Comparator: Placebo<br> | Dietary Supplement: Placebo drink<br>* Isocaloric placebo<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differences in lipolysis rate | Measured as differences in palmitate flux | After 14 days treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in glucose kinetic | Measured by glucose tracer. | After 14 days treatment | 
| Changes in signaling in muscle and adipose tissue |  | After 14 days treatment |
Who Contributes to the Ordering of CT Scans in Emergency Department Patients?

Study Overview
=================
Brief Summary
-----------------
The primary objectives are: To investigate which healthcare workers and other individuals contribute to the decision to order computed tomography (CT) scans for emergency department (ED) patients. To investigate the specific reasons healthcare workers and other individuals order or request CT scans for ED patients. To determine the frequency of clinically important actions following CT scan results. Once the drivers of ED CT utilization are identified, interventions including education, incentives for compliance with evidence-based best practices, and interventions for noncompliance could be targeted appropriately.

Official Title
-----------------
Who Contributes to the Ordering of Computed Tomography in Emergency Department Patients? A Prospective Survey Study

Conditions
-----------------
Emergency

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Patients from age 0 to <17 years, and patients age 18 years and older with traumatic and non-traumatic presentations, who visit Adult and Pediatric EDs and receive a CT scan during their ED visit Exclusion Criteria: Patients older than 17, yet younger then 18. Patients who are unable to consent and who do not have a legally authorized representative.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1<br>All consecutive emergency department patients undergoing CT during study hours will be prospectively enrolled, except for those meeting pre-specified exclusion criteria. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CT scans utilization | Results will be categorized by body region of CT and patient age. For each CT region and age category, the percentage of CT scans requested by each demographic group (e.g., patient, emergency physician, etc.), will be reported, with 95% confidence intervals. CTs not requested by emergency physicians, the percentage of each type of scan requested by each demographic group will be reported, with 95% confidence intervals. | January 2014 - January 2015 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Abnormal vs. normal CT scans | The frequency of abnormal CT results and clinical interventions will be calculated, for CTs requested by emergency physicians and for those not requested by emergency physicians (this includes all other parties). | January 2014 - January 2015 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
CT scan, computed tomography, emergency, ordering behavior, diagnosis, radiation
Short-term Effects of Intravitreal Bevacizumab and Triamcinolone in Patients With Diabetic Macular Edema

Study Overview
=================
Brief Summary
-----------------
Diabetic macular edema is a common complication of ocular diabetes mellitus and can cause blindness. Hypoxygenation of the retina stimulates tissue mediators, especially different subtypes of vascular endothelial growth factor (VEGF). VEGF is responsible for proliferation, extension and increased permeability of the vessels. The aim of our study was to examine the short-term effect of intravitreal bevacizumab (Avastin® 1.25 mg in 0.05 ml) and triamcinolone on visual acuity and central retinal thickness in patients with clinically significant diabetic macular edema (CSME).

Official Title
-----------------
Short-term Effects of Intravitreal Bevacizumab and Triamcinolone in Patients With Diabetic Macular Edema

Conditions
-----------------
Diabetic Macular Edema

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: clinical significant macular edema Exclusion Criteria: retinal thickness < 250 µm

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br> | |
| 2<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Central retinal thickness |  | 4, 8, 12, 24, 72, and 168 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| BCVA |  | 4, 8, 12, 24, 72, and 168 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
OCT, diabetic macular edema
Collection and Characterization of Objective Measures to Explore the Specificity of Algorithms

Study Overview
=================
Brief Summary
-----------------
The aim of this descriptive study is to collect and describe the characteristics of objective measures to explore the specificity of algorithms.

Official Title
-----------------
Trans-impedance Matrix

Conditions
-----------------
Hearing Loss

Intervention / Treatment
-----------------
* Device: Objective measures with CSEP


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Candidate for cochlear implantation with the CI532 or CI512 devices 18 years of age or older at the time of enrolment Normal cochlea anatomy, established via pre-operative Computer Tomography Willingness to participate in and to comply with all requirements of the protocol Exclusion Criteria: Prior cochlear implantation in the ear to be implanted Ossification or any other cochlear anomaly that might prevent complete insertion of the electrode array Abnormal cochlear anatomy on pre-operative Computer Tomography or Magnetic Resonance Imaging Additional handicaps that would prevent participation in evaluations Pregnant and breast feeding women, prisoners, or anyone in custody Unrealistic expectations on the part of the subject, regarding the possible benefits, risks and limitations that are inherent to the procedure

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cochlear Implant Recipients<br> | Device: Objective measures with CSEP<br>* Objective measures to be conducted with Custom SoundTM EP 5 software and the CP900 series sound processor in CI532 and CI512 Cochlear Implant recipients<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Specificity (%) of Transimpedance Measurement to Identify Electrode Fold-over | Measured with Custom SoundTM EP 5. It took one minute to measure all electrodes in surgery. Intraoperative transimpedance measures from 148 ears without fold-overs (as evidenced by radiographic imaging) were analysed to assess the specificity of the algorithm. | at surgery, within one minute |
Stress Among Final Year BAMS Students in Relation With Covid Lockdown Through CSSQ-a Cross Sectional Survey

Study Overview
=================
Brief Summary
-----------------
We were randomly selected the ayurveda colleges in Kerala.Selected final year BAMS students as participants.we have also selected a group of 5 members for data colle tion.we have selected a validated Covid stress questionnaire and circulated through what's app and Gmail.we were received responses from each college with .we analyzed and interpreted data.

Detailed Description
-----------------
We were randomly selected the ayurveda colleges in Kerala.Selected final year BAMS students as participants.we have also selected a group of 5 members for data colle tion.we have selected a validated Covid stress questionnaire and circulated through what's app and Gmail.we were received responses from each college with .we analyzed and interpreted data.

Official Title
-----------------
Covid -19 Related Stress Among Final Year BAMS Students During Lock Down Days in Kerala-A Cross Sectional Study

Conditions
-----------------
Covid Related Psychological Stress

Intervention / Treatment
-----------------
* Other: Survey


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria 1.final year BAMS 2.irrespective of gender - Exclusion Criteria: age group other than 20-22 yrs

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 22 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Survey|It is a survey based on questionnaire|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Likert scale | 4 point likert scale questionnaire | 10 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Stress,covid,lock down days
Effect of Carbohydrates From Nutritional Beverages in Children

Study Overview
=================
Brief Summary
-----------------
This clinical trial will determine the effect of varying types of carbohydrates on children's concentration.

Official Title
-----------------
Effect of Carbohydrates From Nutritional Beverages in Children

Conditions
-----------------
Concentration, Learning

Intervention / Treatment
-----------------
* Other: Nutritional Beverage
* Other: Nutritional Beverage


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children 33 months - 39 months

Ages Eligible for Study
-----------------
Minimum Age: 33 Months
Maximum Age: 39 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Group 1 - Control A<br>Nutritional beverage containing varying types and levels of carbohydrates | Other: Nutritional Beverage<br>* Nutritional Beverage with varying types and levels of carbohydrates<br>|
| Experimental: Group 2 - Experimental A<br>Nutritional Beverage with varying types and levels of carbohydrates | Other: Nutritional Beverage<br>* Nutritional beverage with varying types and levels of carbohydrates<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Concentration | Children's ability to concentrate |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Attention | Measures of Attention and Distractibility |  | 
| Short-Term Memory | Sentence Repetition |  | 
| Rule Learning | Rule Learning Tasks |  |
The Relationship Between Cranial Near-InfraRed Oxygenation(NIRO) and Heart Rate Variability During Mental Exercise

Study Overview
=================
Brief Summary
-----------------
The objective of this study is to investigate the effect of Tai Chi and Qigong practice on cranial oxyhaemoglobin level, blood pressures and autonomic nervous system responses.

Official Title
-----------------
The Relationship Between Cranial Near-InfraRed Oxygenation(NIRO) and Heart Rate Variability During Mental Exercise

Conditions
-----------------
Tai Chi Practitioner, Qigong Practitioner

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: A minimal of 3 years experience on practice of either Tai Chi or Qigong Exclusion Criteria: Unable to communicate or follow an exercise protocol Presence of cognitive impairments Symptomatic cardiovascular diseases Hypertension Diagnosis of stroke Parkinson's disease, or other neurologic disorder, peripheral neuropathy and cancer.

Ages Eligible for Study
-----------------
Minimum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Tai Chi<br>Healthy subjects with Tai Chi practice | |
| Qigong<br>Healthy subjects with Qigong practice | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Level of Oxyhaemoglobin and total Haemoglobin |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart rate variability |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Tai Chi, Qigong, Heart rate variability, Near Infrared Spectroscopy, blood pressure
Prospective ED Headache Cohort Study

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine how often headaches recur and to learn how to predict continued suffering from headache after emergency department discharge.

Detailed Description
-----------------
The majority of the 5 million people who arrive at Emergency Departments (ED) with a headache every year are suffering from an acute exacerbation of a chronic, recurrent headache disorder. The role of the ED in treating these patients has been ill-defined. Often emergency physicians will treat the acute exacerbation and will not attend to the natural history of the disease. However, about two thirds of primary headache patients will suffer a recurrent headache in the 24 hours after discharge from the ED. And, many patients will continue to suffer recurrent headaches for months after their ED discharge. The purpose of this study is to learn how often headaches recur and to try to find a way to predict who will have a recurrent headache after ED discharge. After standard ED treatment for headache, participants in the study will be asked to answer questions about prior headaches and medical history, and some census-like questions about race/ethnicity, salary, and education via a 20-minute interview with a research associate. The researchers will follow-up with 10-minute telephone calls to each participant's home in 24 hours and in 3 months with additional questions. Total length of time for study participation is approximately 40 minutes.

Official Title
-----------------
Predicting Poor Pain and Functional Outcomes After Discharge From the Emergency Department With a Primary Headache

Conditions
-----------------
Headache

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Emergency Department patients who present primarily for headache. Need to consent to and be available for follow-up

Ages Eligible for Study
-----------------
Minimum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants Who Report Moderate or Severe Pain Within 24 Hours of Emergency Department(ED) Discharge | Moderate/ Severe pain after discharge from the Emergency Department (ED). Moderate and severe are study subject's description of pain | 24 hours after Emergency Department (ED) discharge | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
headache, emergency department, migraine, recurrent headache