Olfactogustatory Perception, Eating Behaviour and Inflammation in Crohn's Disease

Study Overview
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Brief Summary
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This study will improve our understanding of the mechanisms underlying anorexia in persons with Crohn's disease flare-ups. The practical spin-off from this research is potentially very important for the management of nutritional disorders associated with the disease by guiding diets towards foods that correspond to patients' preferences and/or to modified tastes. In addition, the results could lead to the identification of sensory markers that herald an inflammatory flare-up of the disease.

Official Title
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Olfactogustatory Perception, Eating Behaviour and Inflammation in Crohn's Disease

Conditions
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Crohn's Disease, Olfactogustatory Perception

Intervention / Treatment
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* Other: triangular test
* Biological: blood sampling
* Other: Questionnaires


Participation Criteria
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Eligibility Criteria
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For patients : Inclusion Criteria: Age between 18 and 60 years, Diagnosis of Crohn's disease according to clinical, endoscopic, histological, radiological and biochemical criteria as defined by the European Consensus Conference, Men or women who have provided consent and willing to cooperate. Exclusion Criteria: Chronic inflammatory intestinal disease (CIID) other than Crohn's disease: haemorrhagic rectocolitis, undetermined colitis, microscopic colitis. Intercurrent disease (diabetes and metabolic disease, liver cirrhosis, progressive cancer, acute or chronic infection, Human Immunodeficiency Virus HIV), Organ failure (respiratory, heart, or renal failure, neurological disorders), Intolerance to gluten, Treatments (other than those used for Crohn's disease) able to interfere with food intake, Aversion to foods consumed or smelled, Poor understanding of cognitive tasks required. Crohn's disease complicated by an abscess or infectious complication Acute Crohn's disease defined by a CDAI score > 150 For Controls: Inclusion Criteria: Adult person Without follow-up for a chronic pathology Having given its consent Exclusion Criteria: Protected adult Person not affiliated to a social security system Pregnant or breastfeeding woman Active smoker No one who does not speak French Taking treatment that interferes with taste or acts on the central nervous system

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Crohn and anti-TNF treatment<br>Tests at 3 or 4 weeks after the beginning of anti-TNF treatment | Other: triangular test<br>* metabolic state, impedance measurement, potential flavours evoked by sucrose,<br>Biological: blood sampling<br>* sampling of 2 mL<br>Other: Questionnaires<br>* Stunkard, PrefQuest<br>|
| Crohn and without anti-TNF treatment<br>tests performed according to patient availability | Other: triangular test<br>* metabolic state, impedance measurement, potential flavours evoked by sucrose,<br>Biological: blood sampling<br>* sampling of 2 mL<br>Other: Questionnaires<br>* Stunkard, PrefQuest<br>|
| Control<br>tests performed according to patient availability | Other: triangular test<br>* metabolic state, impedance measurement, potential flavours evoked by sucrose,<br>Biological: blood sampling<br>* sampling of 2 mL<br>Other: Questionnaires<br>* Stunkard, PrefQuest<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Modification of sweet taste | the measurement of detection thresholds consists in presenting to the participants in order of increasing concentrations, series of forced-choice triangular tests | through the study completion up to 10 years |