Cerebellar Superficial Siderosis in Cerebral Amyloid Angiopathy

Study Overview
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Brief Summary
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Cerebellar superficial siderosis (SS) has been recently reported to be present in about 10% of both hereditary (n=50) and sporadic (n=46) cerebral amyloid angiopathy (CAA) patients on 3T MRI using susceptibility-weighted imaging (SWI) in the majority of patients. In that study, cerebellar SS was associated with a higher number of supratentorial lobar and superficial cerebellar macrobleeds (although cerebellar SS was not directly located adjacent to these cerebellar macrobleeds). It is unclear if cerebellar SS is caused by in situ leakage of cerebellar leptomeningeal vessels or rather represents hemorrhagic diffusion from cerebellar parenchymal micro/macrobleeds or from supratentorial bleeding sources via the tentorium cerebelli (TC).

Official Title
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Cerebellar Superficial Siderosis in Cerebral Amyloid Angiopathy on 1.5T T2*-Weighted Imaging

Conditions
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Cerebral Amyloid Angiopathy, Siderosis

Intervention / Treatment
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* Other: None, pure observational study


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: CAA patients (according to the modified Boston criteria) with acute symptoms related to acute ICH, acute subarachnoid haemorrhage, or cortical SS Exclusion Criteria: Patients with recent trauma, Patients with anticoagulation treatment, Patients with pathological blood coagulation tests (activated partial thromboplastin time [aPTT] ratio=patient's aPTT/normal control aPTT] >1.2; or partial thromboplastin time [PTT] <75%) or platelet count (<100 x 109/L) Patients with inflammatory CAA

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| cerebral amyloid angiopathy (CAA)<br>Clinical and 1.5T MRI T2*-weighted imaging characteristics analyses from sporadic probable CAA patients (according to the modified Boston criteria) presenting with acute symptoms related to acute ICH, acute subarachnoid haemorrhage, or cortical SS, | Other: None, pure observational study<br>* None, pure observational study<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MRI analyse : presence of cerebellar SS | presence of cerebellar SS (Yes/No) | baseline | 
| MRI analyse : Location of cerebellar SS | Location of cerebellar SS (vermis, anterior lobe, posterior lobe) | baseline | 
| MRI analyse : characteristics of cerebellar SS | number of cerebellar sulci involved | baseline | 
| MRI analyse : characteristics of cerebellar SS | spatial relationship with cerebellar micro- and macrobleeds | baseline | 
| MRI analyse : Presence of cerebellar macrobleeds | Presence of cerebellar macrobleeds (Yes/No) | baseline | 
| MRI analyse : Presence of cerebral macrobleeds | Presence of cerebral macrobleeds (Yes/No) | baseline | 
| MRI analyse : Characteristics of cerebral macrobleeds | spatial relationship of cerebral macrobleeds with the TC [adjacent vs. non-adjacent to TC] | baseline | 
| MRI analyse : Characteristics of cortical SS | spatial relationship with TC (adjacent vs. non-adjacent to TC) | baseline | 
| MRI analyse : hemosiderin | presence of hemosiderin deposition along the TC. | baseline |