Comparing the Ketogenic Effect of Coconut Oil and Different MCTs

Study Overview
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Brief Summary
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The aim of this study is to compare the ketogenic effect of coconut oil and three MCT oils (60-40 , tricaprylin and triheptanoate) on the production of ketones in healthy adults. Each oil are evaluated individually or in combination over a 8h-period during which repeated blood sampling is performed.

Detailed Description
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The study is composed of eight successive visits. Each visit consists of the consumption of one individual oil or a mixture of oils (20 g of coconut oil or 10 g of coconut oil + 10 g of MCT 60-40 or 20 g MCT 60-40 or 10 g coconut oil + 10 g tricaprylin or 20 g tricaprylin or 10 g coconut oil + 10 g triheptanoate or 20 g triheptanoate) and a 8h follow-up during which repeated blood samples are taken for laboratory analysis (plasma beta-hydroxybutyrate, acetoacetate, glucose, free fatty acids, triglycerides, total cholesterol, lactate and insulin).

Official Title
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Comparing the Ketogenic Effect of Coconut Oil and Different Medium-chain Triglycerides

Conditions
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Healthy Adults

Intervention / Treatment
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* Dietary Supplement: Coconut oil
* Dietary Supplement: Coconut oil + MCT
* Dietary Supplement: MCT
* Dietary Supplement: Coconut oil + tricaprylin
* Dietary Supplement: Tricaprylin
* Dietary Supplement: Tricaprin
* Dietary Supplement: Control


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy adult over 18 y old. Exclusion Criteria: Fasting plasma glucose ≥7.0 mM (diabetics or pre-diabetics); Smoking Clinically-significant gastro-intestinal disease/conditions. Clinically-significant liver disease/dysfunction. Clinically-significant cardiac disease/conditions. Clinically-significant abnormal coagulation. Taking a medication that could affect lipid and glucose metabolism Hypertension Pregnancy or breastfeeding Exercising more than 3 times a week

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Supplementation<br>Protocol involved seven separate but identical metabolic study days for each participant. the test substances were evaluated in random order: vehicle (Control) or 20 mL of the test oils (Coconut oil; tricaprin; tricaprylin; MCT [tricaprylin/tricaprin]; coconut oil + MCT [50:50]; Coconut oil + tricaprylin [50:50]) taken twice, once at breakfast and once at mid-day. | Dietary Supplement: Coconut oil<br>* 20 g of coconut oil<br>* Other names: Coco;Dietary Supplement: Coconut oil + MCT<br>* 10 g of coconut oil + 10 g of MCT (60 of C8 + 40 of C10)<br>* Other names: Coco+MCT;Dietary Supplement: MCT<br>* 20 g of MCT (60 of C8+40 of C10)<br>Dietary Supplement: Coconut oil + tricaprylin<br>* 10 g coconut oil + 10 g tricaprylin<br>* Other names: Coco+C8;Dietary Supplement: Tricaprylin<br>* 20 g tricaprylin<br>* Other names: C8;Dietary Supplement: Tricaprin<br>* 20 g tricaprin<br>* Other names: C10;Dietary Supplement: Control<br>* No supplement taken on this visit<br>* Other names: CTL;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Plasma Ketone Concentrations | Total ketones = Plasma acetoacetate (µmol/L) + beta-hydroxybutyrate (µmol/L) measured over a 8 hour period (i.e. daily mean). Samples are taken every 30 minutes on a 8 hours period. The mean is reported here. | 8 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Plasma Acetoacetate/Beta-hydroxybutyrate Ratio | Plasma ratio of acetoacetate (µmol/L)/ beta-hydroxybutyrate (µmol/L) measured over a 8 hour period (i.e area-under-the-curve over 8 hours). | 8 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ketones, Coconut oil, Medium Chain Triglycerides