Impact of a Family History of Hypertension and Physical Activity on Left Ventricular Mass

Study Overview
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Brief Summary
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This is a retrospective analysis of data collected within two previous studies. The data has been combined and used to investigate the impact of having a family history of hypertension on left ventricular muscle mass with and without controlling for moderate and vigorous intensity physical activity frequency per week. The hypothesis was that in a sample of mostly active participants, no differences in left ventricular mass between family history of hypertension groups would be observed, but the positive family history of hypertension group would have elevated left ventricular mass compared to the negative family history of hypertension group following statistical control of activity frequency.

Detailed Description
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A positive family history of hypertension (FHH) (+FHH) is associated with elevated left ventricular mass (LVM). Regular physical activity (PA) may eliminate differences in LVM between +FHH and negative family history of hypertension (-FHH) adults. PURPOSE: To determine if a +FHH is associated with a greater LVM compared to a -FHH group within a sample of young, mostly active healthy adults with and without statistically controlling for PA. METHODS: Healthy young (18-32yrs) participants self-reported FHH status and habitual moderate and vigorous PA frequency. Participants then underwent an echocardiogram.

Official Title
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Impact of a Family History of Hypertension and Physical Activity on Left Ventricular Mass

Conditions
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Genetic Predisposition, Genetic Hypertension

Intervention / Treatment
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* Other: Family history of hypertension


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Generally healthy Exclusion Criteria: Known hypertension, cardiovascular disease, current pregnancy, current infectious disease, diabetes mellitus, kidney disease, a history of cancer, pulmonary disease, history of a stroke, obesity (for most people this means a body mass index greater than 30), or any life threatening chronic conditions

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 32 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Positive Family History of Hypertension<br>Young normotensive generally healthy adult with one or more biological parents with diagnosed hypertension. | Other: Family history of hypertension<br>* Presence or absence of a family history of hypertension in a cross sectional study design.<br>|
| Negative Family History of Hypertension<br>Young normotensive generally healthy adult with no biological parent with diagnosed hypertension. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Left Ventricular Mass | Muscle mass in grams of the left ventricle of the heart as estimated by ultrasound. | Day 2 |