The Effect of Thai Traditional Music on Cognitive Function, Psychological Health and Quality of Sleep Among Thai Older Individuals With Dementia

Study Overview
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Brief Summary
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To determine the effect of Thai traditional music on cognitive function, psychological health and quality of sleep among Thai older individuals with dementia.

Detailed Description
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Dementia, regardless of its cause, has been recognized to be one of the most important and common problems among the elderly worldwide. The prevalence of dementia has been increasing gradually throughout the world. It is associated with medical and psychological consequences, especially in the advanced stage of the condition. Medications for dementia, specifically, acetylcholine esterase inhibitors, have proven efficacy but variable individual response. They are very expensive and stress families and insurance payers. Dementia and its neuropsychiatric co-morbidities effects not only individual patients, but also family members and care givers as it stresses interpersonal relationships, increases the need for personal care, nursing home placement, and the use of neuropsychiatric medications. Any new approach to improve cognitive function, behavior, mood and sleep quality among demented individuals therefore could have far reaching benefits for patients, care givers, financially responsive parties, and the country as a whole. There are several studies focusing on the non-pharmacologic approaches to care of the demented. The objectives were to reduce reliance on prescribed medications with these adjunctive therapies. One of the interesting non-drug trials was about music therapy. It was found that music could improve behavioral and social functions among individual demented patients. However, the methodology of each music study varied considerably. To our knowledge, there has been no music study in dementia performed in Thailand using our unique Thai traditional music. We therefore aim to study this non-pharmacologic approach in Thai demented individuals using Thai traditional music. We hypothesized that regular listening to Thai traditional music will improve cognitive function, activities of daily living, mood, behavior and sleep quality in Thai demented patients.

Official Title
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The Effect of Thai Traditional Music on Cognitive Function, Psychological Health and Quality of Sleep Among Thai Older Individuals With Dementia.

Conditions
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Cognitive Function, Sleep

Intervention / Treatment
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* Device: Music CD


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age > 60 years Diagnosed with Alzheimer's disease, vascular dementia or mixed dementia by ICD-10 No change in neuropsychiatric drugs for at least 4-week before and 8-week during the study CD player available at home Patient and care giver consent to study Exclusion Criteria: Severe depression requiring aggressive treatment or hospitalization Dementia with Lewy body, multisystem atrophy Treatable dementia Active medical problems Profound hearing loss

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Lifestyle counselling<br> | Device: Music CD<br>* During 4-week interventional period of each group, a researcher gives a CD to care giver and advises him/her to open the music for patient for at least 60 minutes daily, after dinner to bedtime. Meanwhile, the care giver notes the exact duration that patient actually listens to it in the calendar provided and returns the CD and document to the researcher at the end of interventional period.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Depression | Using Thai Geriatric Depression Scale (TGDS) | 4-week after regularly listening to the music for 28 days | 
| Activities of Daily Living | using AD Cooperative Study Activities of Daily Living Inventory (ADCS/ADL) | 4-week after music | 
| Behavior | Using Behavioral pathology in Alzheimer's Disease Rating Scale (BEHAVE AD) | 4-week after music | 
| Sleep quality | Using Pittsburgh Sleep Quality Index (PSQI) | 4-week after music | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| reduction of the care giver's stress and burden | Using visual analog scale | 4-week after intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Thai traditional music, dementia, Cognitive function, behavioural problem, sleep quality, psychological health, quality of sleep