Effect of Intake of Hydrolyzed Krill Protein Isolate on Plasma Amino Acid Profile

Study Overview
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Brief Summary
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Purpose: To examine the absorption of three different protein sources: hydrolyzed krill protein isolate, whey protein isolate, and soy protein isolate.

Detailed Description
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Design and Method: Randomized, controlled, double-blind cross-study, in which 12 healthy adult young men in randomized order ingest 35 g of protein of crude protein from one of the three protein sources or water on four different experimental days. Before and up to three hours after ingestion of the test beverage, blood samples are collected for 8 time points during each experimental day.

Official Title
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Effect of Intake of Hydrolyzed Krill Protein Isolate, Whey Protein Isolate and Soy Protein Isolate on Plasma Amino Acid Profile

Conditions
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Human Nutrition

Intervention / Treatment
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* Dietary Supplement: Krill protein hydrolysate
* Dietary Supplement: Soy protein isolate
* Dietary Supplement: Whey protein isolate
* Dietary Supplement: Water


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: men 18-30 years Exclusion Criteria: smoking, medication, health issues conflicting with the experimental trial

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Single Group Assignment
Interventional Model Description: Design and Method: Randomized, controlled, double-blind cross-study, in which 12 healthy adult young men in randomized order ingest 35 g of protein of crude protein from one of the three protein sources or water on four different experimental days. Before and up to three hours after ingestion of the test beverage, blood samples are collected for 8 time points during each experimental day.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Krill Protein Hydrolysate<br>Krill Protein Hydrolysate | Dietary Supplement: Krill protein hydrolysate<br>* Ingestion of 35 g Krill protein hydrolysate<br>|
| Active Comparator: Soy protein isolate<br>Soy Protein isolate | Dietary Supplement: Soy protein isolate<br>* Ingestion of 35 g Soy protein isolate<br>|
| Active Comparator: Whey protein isolate<br>Whey protein isolate | Dietary Supplement: Whey protein isolate<br>* Ingestion of 35 g Whey protein isolate<br>|
| Sham Comparator: Control<br>Water | Dietary Supplement: Water<br>* Ingestion of water (control)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Amino acids concentrations | Measurement of changes in amino acids concentrations in the blood | 10 minutes prior to supplement up to 180 minutes after supplement | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual Analogue Scale (VAS) | Measurements of changes in Hunger and satiety using 100 mm Visual Analogue Scores | 10 minutes prior to supplement up to 180 minutes after supplement | 
| Insulin | Changes in serum insulin | 10 minutes prior to supplement up to 180 minutes after supplement | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Protein, Amino Acids, Krill, Whey, Soy, Satiety, Insulin