A Registry Study on Genetics and Biomarkers of Thoracic Aortic Aneurysm/Dissection

Study Overview
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Brief Summary
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This is a national registry study to determine genetic risk factor and serial biomarkers of thoracic aortic aneurysm/dissection

Official Title
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A Chinese Registry to Determine the Genetic Risk Factors and Serumal Biomarkers for Thoracic Aortic Aneurysm/Dissection

Conditions
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Aortic Aneurysm, Thoracic, Aneurysm, Dissecting

Participation Criteria
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Eligibility Criteria
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Case Inclusion Criteria: Subject who was diagnosed as thoracic aortic aneurysm/dissection by CT angiography, interventional angiography or vascular ultrasound; Age is less than 80 years old; male and non pregnancy female; Subject understands study requirements aand agrees to sign an informed consent form prior to any study procedures. Case Exclusion Criteria: Subject has one of the following: Pseudoaneurysm; Previous infection or trauma in the damaged part of aorta; Pregnancy female; Participate in other clinical trials in the last 1 months. Control Inclusion Criteria: Age and gender are matched with cases; No aortic disease was detected by outpatient ultrasound; No family history of cardiovascular disease; Normal biochemical indicators; Criteria for culling, shedding and suspension testing: Culling: Unqualified cases and controls. Data of culled subjects can not be used for statistical analysis; Shedding: Subject that self withdrawal, loss to follow-up, or quitted by doctors; Reasons for shedding should be indicated for each shed subject. Suspension: a) The researchers found significant safety problems or wrong study design; b) Researchers cannot continue clinical research due to funding or management reasons; c) Director ends the study. When suspension happens, all the CRF table should be reserved for future reference.

Ages Eligible for Study
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Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| case<br> | |
| control<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Age for each participant |  | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting | 
| Gender for each participant |  | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting | 
| Height for each participant |  | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting | 
| Weight for each participant |  | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting | 
| Contact information for each participant |  | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting | 
| Past Medical History including disease history, surgical history, and family medical history |  | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting | 
| Lifestyle including smoking history and drinking, specify how many years smoking or drinking lasted and detail quantity per day |  | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting | 
| Exon sequencing data of each participant |  | Sequencing will be carried out in an average of 3 months after sample recruiting | 
| Serum biomarker screening data of each participant |  | Screening will be carried out in an average of 3 months after sample recruiting | 
| The location of Aneurysm/Dissection |  | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting | 
| The size of Aneurysm/Dissection |  | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting | 
| blood biochemical index：blood lipid |  | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting | 
| blood biochemical index：blood glucose |  | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting | 
| blood biochemical index：uric acid |  | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting | 
| blood biochemical index：urea |  | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting | 
| blood biochemical index：creatinine |  | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting | 
| blood biochemical index：C reactive protein |  | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting | 
| blood biochemical index：d dime |  | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting | 
| Drug treatment |  | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting | 
| Surgery type |  | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting | 
| Prognosis information: all-cause death |  | These data is collected during follow-up visit at 3/6/12 months after discharge | 
| Prognosis information: whether recidivation happened |  | These data is collected during follow-up visit at 3/6/12 months after discharge | 
| Prognosis information including: whether other related disease happened |  | These data is collected during follow-up visit at 3/6/12 months after discharge |