Manuka Honey as an Adjunct to Non-surgical Periodontal Therapy: Clinical Study

Study Overview
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Brief Summary
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The goal of this split-mouth clinical trial is to evaluate the effects of Manuka honey applied into periodontal pockets after initial periodontal therapy (NSPT) in the treatment of stage 3 periodontitis. The main question it aims to answer is: • does the adjunct of Manuka honey improve the outcome of the non-surgical periodontal treatment. The intervention in this study was conducted in a split-mouth design, meaning that after completing the NSPT for each subject, Manuka honey was administered as an adjunct to the periodontal treatment in two randomly selected quadrants of the oral cavity around the teeth with a specially designed cannula. This was followed by oral hygiene instructions and training. The home-performed oral hygiene procedures were focused on interdental cleaning using dental floss and toothbrushing with regular fluoride-containing toothpaste. The subjects were also instructed not to use any form of oral antiseptic (e.g., chlorhexidine) or antibiotic during the follow-up period.

Official Title
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Manuka Honey as an Adjunct to Non-surgical Periodontal Therapy: Clinical Study

Conditions
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Periodontal Diseases, Periodontal Pocket, Periodontal Bone Loss, Periodontal Attachment Loss

Intervention / Treatment
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* Biological: Manuka honey


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients of both genders with good systemic health; Non-smokers; Presence of at least 20 teeth; Untreated moderate to advanced generalized chronic periodontitis according to the 1999 Classification 199 , i.e., generalized stage III periodontitis according to the 2007 Classification Exclusion Criteria: Pregnant and nursing women; Antibiotics prescribed for dental or non-dental diseases 6 months before the start of the research; Systemic diseases or the use of drugs known to affect periodontal tissues, bleeding parameters; Acute oral or periodontal inflammation or infection (pericoronitis, necrotizing periodontal diseases, etc.).

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: Split-mouth study
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Manuka honey<br>The intervention in this study was conducted in a split-mouth design, meaning that after completing the NSPT for each subject, Manuka honey was administered as an adjunct to the periodontal treatment in two randomly selected quadrants of the oral cavity around the teeth with a specially designed cannula. The cannula reached the bottom of the periodontal pocket and moved circumferentially around the tooth at 6 sites, and Manuka honey was extruded until the excess of the material was observed in the sulcus. | Biological: Manuka honey<br>* The honey was applied with special designed cannula. The dosage is not exactly define so we inject the amount of honey until until the excess of the material was observed in the sulcus.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Periodontal pocket depth | Evaluation of changes of periodontal pocket depth | Baseline; 12 months | 
| Clinical attachment level | Evaluation of changes in terms of clinical attachment gain | Baseline: 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Periodontitis, Manuka honey, Periodontal pocket depth