Optimization of SPECT Imaging

Study Overview
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Brief Summary
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Single Photon Emission Computed Tomography (SPECT) is a 3D nuclear medicine imaging technique that is used extensively to study the heart and diagnose heart disease. There are three major limitations in SPECT imaging: attenuation or loss of signal, scattering of the signal in the patient tissues and resolution, where the signal gets blurrier the further the nuclear activity is away from the camera. New software, Evolution for CardiacTM, by GE Healthcare and new cameras with computed tomography (CT) decrease the time needed for images to be obtained while maintaining image quality. Evaluation is needed before they become standard of care.

Official Title
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Optimization of SPECT Cardiac Imaging Through Compensation for Attenuation, Resolution Loss and Scatter - The OSCARS

Conditions
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Coronary Artery Disease

Intervention / Treatment
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* Radiation: SPECT/CT processed with Evolution for CardiacTM software


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Intermediate to high risk patients with coronary artery disease who are scheduled for routine SPECT or PET perfusion imaging Exclusion Criteria: Pregnancy and breast feeding Severe narrowing (stenosis) of the aortic valve Severe heart failure

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Evaluation of technology in SPECT<br>Evaluation of the accuracy of SPECT with new technologies for attenuation correction (AC), scatter correction (SC) and resolution recovery (RR) for assessment of myocardial perfusion using Rb-82 PET as the gold standard. | Radiation: SPECT/CT processed with Evolution for CardiacTM software<br>* SPECT/CT to be compared with PET/CT<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| • Determine the accuracy of myocardial perfusion assessment using SPECT with AC/SC/RR compared to Rb-82 PET. | We are proposing a study to evaluate the accuracy of SPECT with the new technologies for attenuation correction (AC), scatter compensation (SC) and resolution recovery (RR) for the assessment of myocardial perfusion in patients with heart disease using Rb-82 perfusion PET as the gold standard for comparison. | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determine the incremental benefit of AC/SC/RR compared to AC alone |  | 2 years | 
| Evaluate the effect on accuracy of using software with RR to reduce the acquisition time to half of the standard time. |  | 2 years | 
| Determine if using a registered diagnostic CT (PET) increases the accuracy of CT-based AC over the lower-quality Hawkeye CT (SPECT). |  | 2 years | 
| Determine if using a single CT scan acquired at stress for attenuation correction of both stress and rest SPECT decreases the accuracy over using CT scans acquired separately at rest and stress. |  | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Diagnostic imaging, Single Photon Emission Computed Tomography, Positron emission tomography, Computed tomography, Attenuation, Resolution, Scatter, Radiopharmaceutical