Air Pollution and Health of COPD Patients

Study Overview
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Brief Summary
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This panel study aims to evaluate the effects of air pollutants on cardiopulmonary health of patients with chronic obstructive pulmonary disease (COPD) and explore the potential biological mechanisms.

Detailed Description
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This panel study was conducted in a group of stable patients with COPD in Beijing, China. The health measurements including lung function, blood pressure and airway inflammation were conducted, and morning urine, exhaled breath condensate, saliva and venous blood were collected at the time of enrollment and at 3, 6 and 9 months after enrollment. Individual exposures to fine particulate matter (PM2.5), black carbon (BC), ozone (O3) and nitrogen dioxide (NO2) were performed for 24 hours at each follow-up. And the daily concentrations of air pollutants were collected from the Beijing Air Quality Real-time Publishing Platform and meteorological data were collected from the National Meteorological Information Center. The linear mixed effects model was used to analyze the association between air pollution and cardiopulmonary health in patients with COPD.

Official Title
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Effect of Air Pollution on Prognosis of Patients With Chronic Obstructive Pulmonary Disease and Its Underlying Biological Mechanism

Conditions
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Chronic Obstructive Pulmonary Disease

Intervention / Treatment
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* Other: Air pollutants


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: doctor-diagnosed stable COPD patients aged 40 to 80 years lived in Beijing for over one year before being recruited Agree to participate and sign the informed consent form. Exclusion Criteria: Patients with a history of acute exacerbation in the last 1 month Patients with other respiratory diseases such as bronchiectasis and asthma.

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Air pollutants|Particulate matter and gaseous pollutants|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lung function | Lung function test was conducted. | Nine months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| COPD Assessment Test scores | COPD Assessment Test (CAT) scores were used to assess quality of life in COPD patients on a scale of 0 to 40, with higher scores associated with poorer outcomes. | Nine months | 
| Modified British Medical Research Council (mMRC) Questionnaire score | Modified British Medical Research Council (mMRC) Questionnaire score was used to assess the severity of dyspnea on a scale of 0 to 4, with a higher score indicating a worse outcome. | Nine months | 
| ST. George's Respiratory Questionnaire scores | ST. George's Respiratory Questionnaire (SGRQ) scores were used to assess quality of life in patients with COPD on a scale of 0 to 100, with higher scores indicating poorer outcomes. | Nine months | 
| Blood pressure | Systolic and diastolic blood pressure of participants were measured at least three times by a trained technician. | Nine months | 
| Respiratory inflammation | Fractional exhaled nitric oxide (FeNO) test was conducted. | Nine months | 
| Airway and systemic oxidative stress levels | Exhaled Breath Condensate (EBC) and urine samples were collected for oxidative stress analysis. | Nine months | 
| Systemic inflammation | Venous blood was collected for determination of systemic inflammatory biomarkers. | Nine months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Air pollution, chronic obstructive pulmonary disease, cardiopulmonary health, biological mechanism