Effect of Extracorporeal Shock Wave in the Treatment of Knee Osteoarthritis

Study Overview
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Brief Summary
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In this study, the effectiveness of ESWT in the treatment of knee OA was investigated from the perspective of cartilage injury，and to prove that shockwave could delay the early and middle stage OA progression by improving cartilage condition

Official Title
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Effect of Extracorporeal Shock Wave in the Treatment of Knee Osteoarthritis

Conditions
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Knee Osteoarthritis, Cartilage Injury

Intervention / Treatment
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* Device: shock wave device


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Knee joint ROM normal or near normal: flexion 110 ° or reach 0 ° or less MR prompt exist cartilage damage, there is no lack of full-thickness cartilage Kellgren - Lawrence (K - L) grade II - III grade The international association of cartilage repair cartilage damage grading system (ICRS) class I - III Informed consent and sign relevant documents Follow doctor's instructions and follow up on time Exclusion Criteria: Metabolic arthritis Trauma of bone joint Inflammatory diseases Previous knee surgery history History of knee cavity injection in the past 6 months Serious cardiovascular diseases, pulmonary diseases or other serious diseases affecting survival, etc

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Treatment group<br> | Device: shock wave device<br>* The experimental group (group ESWT) guided by ultrasound: conventional rehabilitation training is given priority to with strength training, application of pain when necessary, under the guidance of ultrasound ESWT treatment control group (routine rehabilitation group) : conventional rehabilitation training is given priority to with strength training, oral pain when necessary, under the guidance of ultrasound ESWT treatment (shock energy flow density of 0)<br>|
| Sham Comparator: Control group<br> | Device: shock wave device<br>* The experimental group (group ESWT) guided by ultrasound: conventional rehabilitation training is given priority to with strength training, application of pain when necessary, under the guidance of ultrasound ESWT treatment control group (routine rehabilitation group) : conventional rehabilitation training is given priority to with strength training, oral pain when necessary, under the guidance of ultrasound ESWT treatment (shock energy flow density of 0)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| magnetic resonance imaging of knee | t2 mapping | Baseline (before treatment) | 
| magnetic resonance imaging of knee | t2 mapping | Three months after treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Extracorporeal Shock Wave Therapy, Knee Osteoarthritis, Cartilage Injury