linjc16/ctgov huggingface dataset:
Validation of Severity of Illness Scoring Systems in Paediatric Intensive Care Units in Canada

Study Overview
=================
Brief Summary
-----------------
This is a study of the validation of severity of illness scoring systems in Paediatric Intensive Care Units (PICUs) in Canada.

Detailed Description
-----------------
Outcome: Validation and comparison of 2 severity of illness scores in a Canadian PICU population.

Official Title
-----------------
Validation of Severity of Illness Scoring Systems in Paediatric Intensive Care Units in Canada Outcome: Validation and Comparison of 2 Severity of Illness Scores in Canadian PICU Population

Conditions
-----------------
Intensive Care Units, Pediatric

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All children admitted to participating PICUs over a 1 year period.

Ages Eligible for Study
-----------------
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Observational study of physiological status at entry into PICU as a predictor of outcome, comparison of two commonly used scores (PRISM and PIM), Data from children admitted to a Paediatric Intensive Care unit
Identifying Factors Underlying the Discontinuation of Triptans

Study Overview
=================
Brief Summary
-----------------
The objective of this study is to identify reasons migraine patients stop using triptan medications for abortive headache treatment. It is hypothesized that inadequate education of the patient at the time of prescribing the triptan is positively associated with triptan discontinuation.

Official Title
-----------------
Identifying Factors Underlying the Discontinuation of Triptans

Conditions
-----------------
Migraine, Medication Adherence

Participation Criteria
=================
Eligibility Criteria
-----------------
Triptan User Inclusion Criteria: Episodic Migraine or Chronic Migraine Have used a triptan medication in the prior 3 months Have used triptan medications for at least 1 year Triptan Discontinuation Inclusion Criteria: Episodic Migraine or Chronic Migraine Used any triptan medication in the last 2 years Have not used a triptan medication in the last 6 months

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Triptan User<br> | |
| Triptan Discontinued<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Skin Sympathetic Nerve Activity and Sympathetic Tone

Study Overview
=================
Brief Summary
-----------------
There are many sympathetic hyperactivity diseases in the investigators' clinical practice. However, the conventional method to measure the sympathetic nerve activity had many limitations such as clinical application, data interpretation and even therapeutic manipulation. Therefore the investigators would like to develop a non-invasive method to record the sympathetic nerve activity in the investigators' study that can help gathering the sympathetic nerve activity easily in the investigators' daily clinical situation. By the determination of sympathetic nerve activity status, the health caregiver can understand the disease more.

Official Title
-----------------
Using Skin Sympathetic Nerve Activity to Estimate Sympathetic Tone in Human

Conditions
-----------------
Nerve; Disorder, Sympathetic, Healthy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Sympathetic hyperactivity diseases included: hypertension, heart failure atherosclerotic diseases, arrhythmias, cardiomyopathy, pulmonary hypertension, chronic obstructive pulmonary disease, sleep apnea, pulmonary embolism, hepatitis, liver cirrhosis, hepatopulmonary syndrome, hepatorenal syndrome, renal failure, nephritis, irritable bowel syndrome. Healthy Volunteers Exclusion Criteria: Pregnant

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| The general public<br>people between 20-85 years old, without sympathetic hyperactivity disease | |
| Sympathetic hyperactivity diseases<br>Sympathetic hyperactivity diseases included: hypertension, heart failure atherosclerotic diseases, arrhythmias, cardiomyopathy, pulmonary hypertension, chronic obstructive pulmonary disease, sleep apnea, pulmonary embolism, hepatitis, liver cirrhosis, hepatopulmonary syndrome, hepatorenal syndrome, renal failure, nephritis, irritable bowel syndrome. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Skin Sympathetic Nerve Activity | The Sympathetic Nerve Activity Recording from the skin of the subjects in the day time. | 12 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ventricular arrhythmia | The electrocardiogram recording from the telemetry. | 24 to 72 hours | 
| Mortality | The mortality will be accessed by the chart review and telephone access | 1 to 12 months | 
| Morbidity | The morbidity will be accessed by the chart review and telephone access | 1 to 12 months |
Effects of Light and Exercise on Human Circadian Rhythms and Performance

Study Overview
=================
Brief Summary
-----------------
Both light and exercise are effective countermeasures for space and ground-based crews for circadian phase resetting and alertness levels. The investigators propose to test the combined effects of these two countermeasures to determine whether adding exercise to light stimuli will further improve circadian phase resetting and alertness.

Official Title
-----------------
Effects of Light and Exercise on Human Circadian Rhythms and Performance

Conditions
-----------------
Circadian Rhythm

Intervention / Treatment
-----------------
* Behavioral: Light and exercise


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy by history, physical exam, laboratory studies of blood and urine, and psychological screening moderate-intensity exercise for at least 150 minutes per week Exclusion Criteria: color blind no prescription medications, except hormonal birth control in females

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Light and exercise<br>Exposure to light with exercise | Behavioral: Light and exercise<br>* Exposure to light and exercise<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Circadian Phase | Circadian Phase will be measured using the change in timing of the melatonin rhythm on different days of the protocol. Melatonin will be assayed in blood and/or saliva. | 8 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Subjective alertness | Subjective alertness will be measured using the change in values on standardized mood scales on different days of the protocol. | 8 days |
Yoga@Work Intervention to Reduce Work-related Stress Among Information Technology Workers

Study Overview
=================
Brief Summary
-----------------
Over the last several decades, occupational stress at workplace comprise a major burden. Office based work are more prone to sedentary lifestyle, postural issues, workplace stress, repetitive strain injury, poor employee health. Workplace wellness programs has been very feasible access to employees at their own convenience and need. Yoga@Work Program was developed to suit the need for information technology workers.

Official Title
-----------------
Yoga@Work Intervention to Reduce Work Related Stress Among Information Technology Workers: Waitlist Controlled Trial

Conditions
-----------------
Occupational Stress, Psychological Stress

Intervention / Treatment
-----------------
* Other: Yoga


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Information Technology employee, or trainee willing and able to participate in a 6-week self-care program during the work day. Willing to give informed consent Exclusion Criteria: medical or psychiatric conditions limiting practice of yoga in general Cognitive impairment

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Yoga@Work<br>Yoga session were developed to practice at work anytime feasible. | Other: Yoga<br>* Each yoga session included warm-up practices (for the large joints, spine, and extremities), Simple postures (Asana), breathing exercises (pranayama) and meditation/relaxation. All the yoga participants were given handouts to practice everyday at work as its feasible<br>|
| No Intervention: Wait list Control group<br>Control group with no intervention. After Intervention period, group was offered same sessions. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reductions in occupational stress | Perceived Stress Scale | From baseline to 6-week post intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mental health problems | General Health questionnaires consists of 12 items, each assessing the severity of a mental problem | From baseline to 6-week post intervention |
Molecular Analysis in Peritoneal Washing Citology for Locally Advanced Gastric Cancer

Study Overview
=================
Brief Summary
-----------------
Gastric carcinoma is a disease with a high mortality. Peritoneal washing cytology has a recognized prognostic utility. However sensibility of this study is not appropriate. Studies with PCR (polymerase chain retrotranscription) can increase sensibility and accurate staging information. Objective: To analyze the sensibility and specificity of the expression of CK20, CEA and Ber-EP4 with PCR technique in peritoneal washings of advanced gastric carcinoma without clinical evidence of peritoneal carcinomatosis. Methodology: Retrotranscription analysis (RT-PCR) and quantitative PCR (qPCR) of CK20, CEA and Ber-EP4 in peritoneal washing. Test the feasibility of qPCR with this new marker (Ber-EP4). Comparison of the results with data obtained with conventional cytology. Study of peritoneal recurrence.

Official Title
-----------------
Pilot Study of Comparative Molecular Analysis CK20, CEA and BER-EP4 in Peritoneal Washing Citology for Locally Advanced Gastric Cancer and Their Ability to Predict Peritoneal Dissemination

Conditions
-----------------
Gastric Cancer, Polymerase Chain Reaction

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with resectable advanced gastric cancer Informed consent Exclusion Criteria: Macroscopic peritoneal carcinomatosis Non operable patients

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| specific markers in peritoneal cells | Detection of CK20, CEA and BER-EP4 by PCR technique in peritoneal washing of advanced gastric cancer | during surgical intervention | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Polymerase Chain Reaction, gastric cancer, citology, peritoneal washing, CK20, CEA, BER-EP4
STUDY OF GLUCOSE IN DIALYSIS WATER WITH REGARD TO BLOOD PRESSURE AND QUALITY OF LIFE

Study Overview
=================
Brief Summary
-----------------
We wanted to test the hypotheses that blood pressure level was lower, that the variability of blood pressure and blood glucose was reduced, and that quality of life was improved when glucose was added to the dialysis fluid.

Detailed Description
-----------------
The purpose of the study was to determine the effect of glucose added to the dialysis fluid on 1.blood pressure and variation in blood pressure, 2.blood glucose and variation in blood glucose, and 3.quality of life in patients treated with chronic maintenance hemodialysis in a randomized, placebo-controlled, unblinded cross-over study.

Official Title
-----------------
PHASE 4 STUDY OT THE EFFECT OF GLUCOSE ADDED TO THE DIALYSIS FLUID ON BLOOD PRESSURE, BLOOD GLUCOSE AND QUALITY OF LIFE IN HEMODIALYSIS PATIENTS.

Conditions
-----------------
Hemodialysis

Intervention / Treatment
-----------------
* Drug: dialysisis with and without glucose in the dialysis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age more than 18 years, both men and women, and hemodialysis treatment for more than three months Exclusion Criteria: treatment with hemodiafiltration, change to another dialysis modality, renal transplantation, alcohol abuse defined as more than 21 drinks a week for men and more than 14 drinks a week for women, and unwillingness to participate.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: dialysisis with and without glucose in the dialysis|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Blood pressure;, chronic renal failure;, diabetes mellitus;, dialysis fluid; glucose;, hemodialysis;, hypertension;, uremia.
Worldwide Sarcoidosis Research Study

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to collect information about the clinical course and characteristics of sarcoidosis patients around the world through web-based surveys. Recruitment is directed at and driven by patients in the sarcoidosis community. This will allow the the investigators to study sarcoidosis patients across all demographic, geographic, and socioeconomic boundaries, not just patients seen at large research centers. The investigators believe this study can give investigators a broader and less biased view of sarcoidosis. The investigators would also like to collect genetic samples on this population to assess genetic variance in different phenotypes. The information for the study would be provided through a web based survey system that can be accessed by patients or physicians of patients from any computer with Internet access. This system would collect clinical information in sufficient detail so that the phenotype of individual patients can be evaluated. Upon agreeing to participate in further research studies through the website, subjects will also have the opportunity to provide a DNA sample.

Official Title
-----------------
Worldwide Sarcoidosis Research Study

Conditions
-----------------
Sarcoidosis

Intervention / Treatment
-----------------
* Other: Survey


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of Sarcoidosis Access to a computer with Internet Exclusion Criteria: None

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Survey|Longitudinal surveys|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Define and characterize sarcoidosis phenotypes and methods of care | To give a broader and less biased view of sarcoidosis | Anticipated by 2017 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Sarcoidosis, WISE, Sarcoid Study, Worldwide Sarcoidosis Research Study
Arthroscopic Assisted Lateral Soft Tissue Release for Hallux Valgus

Study Overview
=================
Brief Summary
-----------------
Lateral soft tissue release is commonly performed as part of the surgical correction of hallux valgus. This study will look at the results form a series of patients whom have underwent the arthroscopic lateral soft tissue release.

Official Title
-----------------
Case Series Regarding the Efficacy of the Arthroscopic Assisted Lateral Soft Tissue Release for Hallux Valgus

Conditions
-----------------
Hallux Valgus, Hallux Valgus and Bunion

Intervention / Treatment
-----------------
* Procedure: Arthroscopic lateral soft tissue release


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion: >18 and legally fit for consent Symptomatic hallux valgus with HVA >15 degrees Exclusion: Active physical or mental disorders that could affect rehabilitation including Other conditions affecting ambulation: lower limb injury, neuromuscular problems etc. Mental incapacitation Previous hallux valgus surgery

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: case series
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: ArtDSTP<br>Arthroscopic lateral soft tissue release | Procedure: Arthroscopic lateral soft tissue release<br>* The arthroscopic lateral soft tissue release is performed using an inside-out approach via the 1MTPJ arthroscopy.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HVA | • Hallux valgus angle (HVA) measured on a weight-bearing DP radiograph | 12 weeks post-surgery | 
| HVA | • Hallux valgus angle (HVA) measured on a weight-bearing DP radiograph | 52 weeks post-surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Arthroscopy
Pulmonary Embolism and Stroke in Patient With Patent Foramen Ovale

Study Overview
=================
Brief Summary
-----------------
The cause of ischemic stroke remains frequently unknown. In patients with patent foramen ovale (PFO), the link between PFO and Stroke is unclear. The investigators hypothesize that the main mechanism is paradoxical embolism and decided to look for clinically apparent and silent cerebral embolism in patients with a recent pulmonary embolism.

Detailed Description
-----------------
Inclusion criteria : age > 18 years old confirmed pulmonary embolism informed consent social ensured Exclusion criteria : pregnancy age < 18 years old protected major person (in sense of public health) consent refused MRI contraindications

Official Title
-----------------
Is There a Link Between Venous Thromboembolism and Stroke in Patient With Patent Foramen Ovale ? Research for Stroke in Hospitalized Patients With Pulmonary Embolism.

Conditions
-----------------
Recent Stroke, Pulmonary Embolism, Patent Foramen Ovale

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age > 18 years old confirmed pulmonary embolism informed consent social ensured Exclusion Criteria: pregnancy age < 18 years old protected major person (in sense of public health) consent refused MRI contraindications

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Incidence of recent stroke in patients with PFO<br> | |
| Incidence of recent stroke in patients without PFO<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of recent ischemic stroke in patients hospitalized for a recent pulmonary embolism with comparison in two groups with and without PFO |  | 7 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Patent Foramen Ovale, Pulmonary embolism, Stroke