Mineral Nano Pathology

Study Overview
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Brief Summary
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Hip arthroplasty is a treatment widely used in most inflammatory, traumatic and degenerative conditions of this joint. The longevity of implants may be disappointing in some cases, despite the promising results obtained during in vitro simulations. Early loco-regional or systemic dissemination, known since the 1990s, of wear particles from these prosthesis may reduce their life span. The analysis of the particles in the synovial fluid and in the articular tissues by electron microscopy after digestion or directly by optical microscopy, will improve the knowledge on the mechanisms of wear. This category 3 study is based on the case-control model and will be conducted in a national reference center (hospital la Croix-Rousse- Lyon). It will include a population of adult patients.

Official Title
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Mineral-Nano-Pathology : Wear of Hip Implants

Conditions
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Arthroplasty

Intervention / Treatment
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* Procedure: hip prosthesis removed metal / polyethylene, simple mobility
* Procedure: hip prosthesis removed metal / polyethylene, double mobility
* Procedure: hip prosthesis removed ceramic/ polyethylene, simple mobility
* Procedure: hip prosthesis removed ceramic/ polyethylene, double mobility
* Procedure: Primary implanted hip prosthesis
* Procedure: hip prosthesis removed metal/metal
* Procedure: hip prosthesis removed ceramic/ceramic


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patient, Patient including French, Patient witness: to be hospitalized in the orthopedic department of the Croix-Rousse hospital for a first hip prosthesis Patient test: to be hospitalized in the orthopedic department of the Croix-Rousse hospital for the removal of a hip prosthesis Exclusion Criteria: Patient protected by law (guardianship, curatorship, safeguard of justice). Pregnant or lactating woman Patient with suspicion of infection on prosthesis Patient opposing his participation in the study

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| hip prosthesis metal/polyethylene in simple mobility<br> | Procedure: hip prosthesis removed metal / polyethylene, simple mobility<br>* Patients are hospitalized in order to change their hip prosthesis at the hospital la Croix-Rousse in Lyon. Patients have to complete before the surgery a survey on occupational and environmental exposures to mineral dust. The prosthesis removed is composed by metal/polyethylene. It's a simple mobility The aim is to define the types of particles that cause the most tissue inflammation<br>|
| hip prosthesis metal/polyethylene in double mobility<br> | Procedure: hip prosthesis removed metal / polyethylene, double mobility<br>* Patients are hospitalized in order to change their hip prosthesis at the hospital la Croix-Rousse in Lyon. Patients have to complete before the surgery a survey on occupational and environmental exposures to mineral dust. The prosthesis removed is composed by metal/polyethylene. It's a double mobility. The aim is to define the types of particles that cause the most tissue inflammation<br>|
| hip prosthesis ceramic/polyethylene in simple mobility<br> | Procedure: hip prosthesis removed ceramic/ polyethylene, simple mobility<br>* Patients are hospitalized in order to change for their hip prosthesis at the hospital la Croix-Rousse in Lyon. Patients have to complete before the surgery a survey on occupational and environmental exposures to mineral dust. The prosthesis removed is composed by ceramic/polyethylene. It's a simple mobility. The aim is to define the types of particles that cause the most tissue inflammation<br>|
| hip prosthesis ceramic/polyethylene in double mobility<br> | Procedure: hip prosthesis removed ceramic/ polyethylene, double mobility<br>* Patients are hospitalized in order to change their hip prosthesis at the hospital la Croix-Rousse in Lyon. Patients have to complete before the surgery a survey on occupational and environmental exposures to mineral dust. The prosthesis removed is composed by ceramic/polyethylene. It's a double mobility. The aim is to define the types of particles that cause the most tissue inflammation.<br>|
| Primary implanted hip prosthesis<br> | Procedure: Primary implanted hip prosthesis<br>* Patients are hospitalized in order to have a first hip prosthesis at the hospital la Croix-Rousse in Lyon. Patients have to complete before the surgery a survey on occupational and environmental exposures to mineral dust. The patients will be received a first prosthesis.<br>|
| metal / metal prosthesis removed<br> | Procedure: hip prosthesis removed metal/metal<br>* Patients are hospitalized in order to change their hip prosthesis at the hospital la Croix-Rousse in Lyon. Patients have to complete before the surgery a survey on occupational and environmental exposures to mineral dust. The prosthesis removed is composed by metal/metal. The aim is to define the types of particles that cause the most tissue inflammation<br>|
| ceramic / ceramic prosthesis removed<br> | Procedure: hip prosthesis removed ceramic/ceramic<br>* Patients are hospitalized in order to change their hip prosthesis at the hospital la Croix-Rousse in Lyon. Patients have to complete before the surgery a survey on occupational and environmental exposures to mineral dust. The prosthesis removed is composed by ceramic/ceramic. The aim is to define the types of particles that cause the most tissue inflammation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| types of particles that cause the most tissue inflammation | Types of wear particles most found in patients whose tissues are classified as inflammatory. The particles can be classified by size, shape, material and type of original prosthesis. | day of surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hip arthroplasty, hip prosthesis resection, first implantation, wear particles