Optimizing Meal and Snack Timing to Promote Health

Study Overview
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Brief Summary
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This study will be conducted using standardized techniques to collect blood samples via an acute, randomized, cross-over design. Subjects will be provided all of their meals the day prior to testing and participate in 3 testing days with a minimum of 1 week break between testing days and a maximum time commitment of 7 weeks. A trained phlebotomist will place a catheter and collect blood samples from an antecubital vein using sterile techniques.

Official Title
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Optimizing Meal and Snack Timing to Promote Health

Conditions
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Dietary Modification

Intervention / Treatment
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* Dietary Supplement: 10 + 20 g protein consumption
* Other: 30 g protein breakfast
* Other: 10 g protein breakfast


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 25-39 years old BMI between 22-37 kg/m2 Weight stable (± 4.5 kg) for the previous 3 months Not currently (or within the past 6 months) following a vigorous exercise regimen or weight loss program No acute illness Not smoking Not diabetic Not pregnant or planning pregnancy in the next 3 months Lactose tolerant Willing to limit purposeful activity for 48 hours prior to each testing day Willing to consume study foods and beverages. Exclusion Criteria: <25 or >39 years old, BMI <22 or >37 kg/m2 Currently (or within the past 6 months) following a vigorous exercise regimen greater than -3 - 45 minute exercise sessions per week Currently following a weight loss program where subject has lost greater than 4.5 kg Acute illness Smoking Diabetic Pregnant or planning pregnancy in the next 3 months Lactose intolerant Unwilling to consume study foods and beverages Peri and post-menopausal women.

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 39 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 10 + 20 g protein consumption<br>10 g breakfast followed by the consumption of a 20g whey protein shake | Dietary Supplement: 10 + 20 g protein consumption<br>* whey isolate<br>|
| Active Comparator: 30 g protein breakfast<br> | Other: 30 g protein breakfast<br>* 30 g mixed meal breakfast<br>|
| Active Comparator: 10 g protein breakfast<br> | Other: 10 g protein breakfast<br>* 10 g mixed meal breakfast<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Plasma amino acid concentration | Peak plasma concentration of amino acids | 7 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood glucose concentration | Area under the curve of blood glucose | 7 weeks |