Magnetic Resonance Imaging in Cerebral Small Vessel Disease

Study Overview
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Brief Summary
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Cerebral small vessel disease (cSVD) accounts for 20% of ischemic strokes and is the most common cause of vascular cognitive impairment. Early identification of cSVD is critical for early intervention and improve clinical outcomes. Magnetic resonance imaging (MRI) may represent as a sensitive and robust tool to detect early changes in brain subtle structures and functions. The study is to investigate the comprehensive evaluation of brain structures and vascular functions by using advanced MRI technologies in early diagnosis and management of cSVD.

Detailed Description
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Cerebral small vessel disease (cSVD) accounts for 20% of ischemic strokes and is the most common cause of vascular cognitive impairment. Early identification of cSVD is critical for early intervention and improve clinical outcomes. Magnetic resonance imaging (MRI) is sensitive to change in white matter structure and subtle vascular function alternation which correlates with cognition impairments in cSVD. MRI manifestation may also represent as useful surrogate marker. Development of advanced MRI technologies promotes their invaluable application in brain and vascular qualitative and quantitative assessment. The study is to investigate the comprehensive evaluation of brain structures and vascular functions by using advanced MRI technologies in early diagnosis and management of cSVD.

Official Title
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Magnetic Resonance Imaging in Cerebral Small Vessel Disease

Conditions
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Cerebral Small Vessel Diseases, MRI

Intervention / Treatment
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* Diagnostic Test: Magnetic resonance imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical evidence of cerebral small vessel disease or MRI evidence of lacunar infarcts and white matter hyperintensity No disability (modified Rankin's scale < 2) No dementia (MMSE > 24 and absence of dependence in daily activities) Able and willing to consent Exclusion Criteria: Contraindications to MRI Standard MRI of bad quality due to movement artefacts Pregnant Unable to tolerate MRI

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cerebral small vessel disease group<br>Patients with clinically and radiologically evidenced cerebral small vessel disease. Patients are grouped by severity of cerebral small vessel disease assessed by comprehensive MRI findings. | Diagnostic Test: Magnetic resonance imaging<br>* Patients recruited will receive Magnetic resonance imaging.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression in total cerebral small vessel disease burden | Total cSVD burden assessed by MRI | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression in congnitive impairments | Global Z-score by cognitive domain | 1 years | 
| Recurrent ischemic events | Recurrent ischemic stroke, TIA and vascular death | 1 year | 
| Modified Rankin Scale | Disability assessed by modified Rankin Scale (mRS). The scores, ranging from 0 (no symptoms) to 6 (death), were recorded by phone call or outpatient consultation. A favorable outcome was defined as mRS score 0-2, unfavorable outcome was defined as mRS score > 2. | 90 days and 1 year after qualifying event | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cerebral small vessel diseases, Cognitive impairments, Lesion burden, MRI