Incidence of Urinary Tract Infection After Urodynamic Investigation

Study Overview
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Brief Summary
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The purpose of this study is to evaluate the incidence of urinary tract infection after urodynamic investigation and to identify the involved germs.

Detailed Description
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Patients with neurogenic bladder dysfunction after spinal cord injury need lifelong urologic control examinations with CMG (urodynamic examination). The manipulation may cause urinary tract infections which have to be treated. Patients often noticed an infection after a CMG examination. Aim of this study is the determination of the infection rate and germs. Also should be noticed the pre-interventional infections and differences between the causing germs. Simultaneously the investigators test the reliability of the quicktest for urinary infection. Additionally the investigators will examine the Quality of Life in patients with neurogenic bladder dysfunction.

Official Title
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Incidence of Urinary Tract Infection and Germ Identification After Urodynamic Investigation in Patients With Spinal Cord Injury

Conditions
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Neurogenic Bladder

Intervention / Treatment
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* Procedure: urodynamic examination


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with neurogenic lower urinary tract dysfunction with scheduled urodynamic investigation No antibiotic treatment Written informed consent Exclusion Criteria: Pregnancy and breastfeeding Current antibiotic therapy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Spinal cord injured<br>Patients with neurogenic lower urinary tract infection (Spinal Cord Injury,MS,M. Parkinson) | Procedure: urodynamic examination<br>* Standard urodynamic investigation according to the ICS standard, Good urodynamic practice.Following insertion of 8 F transurethral catheter, retrograde filling of the bladder (20 mL/min) with body warm saline. Current recording of pabd. , pves and pdet., subsequently pressure flow study. Additionally imaging with fluoroscopy to detect possible vesico ureteral renal reflux.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of urinary tract infection following urodynamic investigation | every patient receives the urine examination before the urodynamic investigation and hospitalized patients additionally 3 days later and ambulatory patients in case of urinary tract infection | 3 days after urodynamic investigation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Name and number of identified bacterial species |  | 30 minutes before examination | 
| Number of hospitalized and number of ambulatory patients with infection of the lower urinary tract |  | 3 days after examination | 
| Incidence of urinary tract infection before urodynamic investigation | every patient receives the urine examination before the urodynamic investigation to detect a potentially urinary tract infection | 30 minutes before urodynamic investigation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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urinary tract infection, urodynamics, spinal cord injury