Immuno-inflammation in the Acute Phase of an Ischaemic Cerebral Accident Managed by Decompressive Hemicraniectomy: a Case-control Study

Study Overview
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Brief Summary
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The objective of the NEUTROSURGERY study is to describe the local and locoregional immuno-inflammatory activity in patients suffering from malignant sylvian ischaemic cerebral accident and treated with decompressive hemicraniectomy compared to a control population of patients to be operated on in neurosurgery for another neurosurgical pathology.

Official Title
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Immuno-inflammation in the Acute Phase of an Ischaemic Cerebral Accident Managed by Decompressive Hemicraniectomy: a Case-control Study

Conditions
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Ischemic Cerebrovascular Accident

Intervention / Treatment
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* Procedure: Decompressive hemicraniectomy
* Procedure: neurosurgical operation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria Patients: Collegial indication given by a neurologist, a neuroreanimator and a neurosurgeon for HD in the context of a malignant sylvian AIC. Inclusion Criteria Control: - For neurosurgical operations in which cranial, meningeal, vascular (branch of the middle meningeal artery) or cerebral bone tissue is not preserved during the surgical approach. Non-inclusion Criteria Patients: HD carried out in a context of acute cerebral haemorrhage Pre-existing neurological disability: modified Rankin score > 2 Patient benefiting from a legal protection measure Non-inclusion Criteria Controls: Patient to be operated on for an acute vascular condition: meningeal haemorrhage, subdural or extradural haemorrhage, intra parenchymal haemorrhage. Patient operated on for an osteomeningeal pathology present at the approach site. Patient operated on for an infectious cranial or neuro-meningeal pathology. Patient to be operated on as a result of an intracranial traumatic condition

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental group<br>Patients suffering from malignant sylvian ischaemic cerebral accident and treated with decompressive hemicraniectomy. Intervention is decompressive hemicraniectomy in the context of a malignant sylvian ischaemic cerebral | Procedure: Decompressive hemicraniectomy<br>* Decompressive hemicraniectomy in the context of a malignat sylvian ischaemic cerebral accident<br>|
| Control group<br>Patients not suffering from AIC, hospitalised in neurosurgery for another reason, Patients to be opered on which cranial, meningeal, vascular (branch of the middle meningeal artery) or cerebral bone tissue is not preserved during the surgical approach. | Procedure: neurosurgical operation<br>* neurosurgical operation on which cranial, meningeal, vascular (branch of the middle meningeal artery) or cerebral bone tissue is not preserved during the surgical approach.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| neutrophil polynuclear cells levels |  | Day 0 |