Investigation of Hand Functions and Related Parameters in People With Multiple Sclerosis

Study Overview
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Brief Summary
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The upper extremity in people with Multiple Sclerosis (pwMS) has become a more popular research topic in recent years, with the increase in studies reporting widespread involvement. The aim of our study was to evaluate the upper extremity from multiple perspectives in early stage pwMS, to identify problems by comparing them with healthy individuals, and to examine the relationship of problems with activity and participation.

Official Title
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Investigation of Hand Functions and Related Parameters in People With Multiple Sclerosis in the Very Early Stage.

Conditions
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Multiple Sclerosis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: MS diagnosis according to McDonald criteria Relapsing Remitting MS clinical course type 18-65 age range Being able to understand and read Turkish Exclusion Criteria: Having an MS attack in the last 3 months To have done regular exercise for the upper extremity in the 6 months before starting the study Having different neurological, orthopedic or cardiac problems other than MS Being addicted to alcohol or drugs Getting a score below 24 on the Mini Mental Test Scale Having a spasticity of 3 or more according to the Modified Ashworth Scale

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Multiple Sclerosis<br>Individuals with early-stage multiple sclerosis | |
| Healthy Volunteers<br>Healthy volunteers of similar age and sex as individuals with multiple sclerosis | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nine Hole Peg Test | To assess upper extremity function. Completing the test in a short time (seconds) indicates better upper extremity function. | baseline (on the predetermined assessment day) | 
| Minnesota Manual Dexterity Test | To assess upper extremity function. Completing the test in a short time (seconds) indicates better upper extremity function. | baseline (on the predetermined assessment day) | 
| ABILHAND | To assess for performance of activity. Score range 0-46 point, higher scores mean a better outcome. | baseline (on the predetermined assessment day) | 
| Motor Activity Log-28 | To assess for performance of activity. Score range 0-5 point, a high score indicates good upper extremity use frequency and quality of movement during activity. | baseline (on the predetermined assessment day) | 
| Community Integration Questionnaire | To assess participation. The total score ranges from 0-29, and the higher the score, the higher the individual's participation in society is considered. | baseline (on the predetermined assessment day) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hand Held Dynamometer | To assess upper extremity muscle strength. Higher scores indicate better muscle strength. | baseline (on the predetermined assessment day) | 
| Hand Dynamometer | To assess grip strength. Higher scores indicate better muscle strength. | baseline (on the predetermined assessment day) | 
| Pinchmeter | To assess pinch strength. Higher scores indicate better muscle strength. | baseline (on the predetermined assessment day) | 
| Tuning fork | To assess deep sense. A higher score indicates better sensitivity. | baseline (on the predetermined assessment day) | 
| Aesthesiometer | To assess two-point discrimination. A higher score indicates worse sensitivity. | baseline (on the predetermined assessment day) | 
| Fatigue Severity Scale | To assess the severity of fatigue. Score range 1-7 point, a higher score indicates more severe fatigue. | baseline (on the predetermined assessment day) | 
| Symbol Digit Modalities Test | To assess cognitive level. A higher score indicates better cognitive level. | baseline (on the predetermined assessment day) | 
| Hospital Anxiety and Depression Scale | To assess anxiety and depression. The total score ranges from 0 to 21 for each of the two subscales. A higher score indicates more severe anxiety and depression. | baseline (on the predetermined assessment day) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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multiple sclerosis, upper limb function, activity, participation