Randomized Comparison of Continuous and Intermittent Heparin Infusion During Catheter Ablation of Atrial Fibrillation

Study Overview
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Brief Summary
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Optimal anticoagulation using heparin with close attention to maintain therapeutic dosing during the procedure is important. Randomized comparison of continuous and intermittent heparin infusion during catheter ablation of Atrial Fibrillation.

Detailed Description
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Intravenous heparin was used during the procedure to prevent catheter-induced thrombosis. heparin is administered during the procedure to achieve recommended activation clotting times (ACT) values, typically >300 seconds to prevent thromboemboli during the procedure. Most of the practitioners was that ACT level should be checked at 30- to 60-minute intervals and then have injected intermittently. intermittent heparin infusion, concentration is great changed because the heparin has 30minutes half-period. researchers postulate that a constant therapeutic concentrations would be beneficial to continuous infusion than intermittent infusion.

Official Title
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Randomized Comparison of Continuous and Intermittent Heparin Infusion During Catheter Ablation of Atrial Fibrillation

Conditions
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Coagulation; Intravascular

Intervention / Treatment
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* Drug: Continuous heparin infusion
* Drug: Intermittent heparin infusion


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Atrial Fibrillation, Radiofrequency catheter ablation scheduled Exclusion Criteria: Clinical trial denied
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Continuous heparin infusion group<br>continuous group is given an initial intravenous heparin 100u/kg and then maintain heparin infusion during procedural. | Drug: Continuous heparin infusion<br>* continuous group is given an initial intravenous heparin 100u/kg and then maintain heparin infusion during procedural.<br>|
| Active Comparator: Intermittent heparin infusion group<br>Intermittent group is given an initial intravenous heparin 100u/kg. Then The ACT is tested every 30min with administration of additional heparin boluses and titration of the heparin drip based on the results and according to the judgment of the operating physician. | Drug: Intermittent heparin infusion<br>* Intermittent group is given an initial intravenous heparin 100u/kg. Then The ACT is tested every 30min with administration of additional heparin boluses and titration of the heparin drip based on the results and according to the judgment of the operating physician.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| therapeutic ACT retention rate during procedure |  | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Continuous heparin infusion, Intermittent heparin infusion, during catheter ablation