The Acute Effects of Oleic Acid Enriched-diets on Lipids, Insulin Sensitivity and Serum Inflammatory Markers

Study Overview
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Brief Summary
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Objectives: To investigate the acute effects of olive oil, palm olein and lard on lipid profile, insulin sensitivity and inflammatory markers. Hypothesis: Different dietary fats will alter lipid profile, insulin sensitivity and inflammatory markers postprandially.

Detailed Description
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A randomized, single blind, crossover design was undertaken to test meals enriched with palm olein vs olive oil vs lard. Volunteers were asked to participate in three postprandial challenges, separated by at least 3-days. Subjects were provided a low fat meal(<10g fat) the day before the intervention. Fasting blood was collected the next day and the subjects were instructed to consume test meals (50g high fat meal). Further venous blood was collected at 30 min, 1h, 2h, 3h and 4h postprandially. Primary outcome variable: Triacylglycerol (TAG) Secondary outcome variables: Insulin sensitivity (glucose, insulin), non esterified fatty acids (NEFA), inflammatory markers

Official Title
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The Acute Effects of Oleic Acid Enriched-diets on Lipids, Insulin Sensitivity and Serum Inflammatory Markers

Conditions
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Lipid Profile

Intervention / Treatment
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* Dietary Supplement: The acute effects of dietary fat on lipid profile, insulin sensitivity and inflammatory markers


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age: 18-45 years BMI : 18.5-30 kg/m^2 Healthy, men Exclusion Criteria: medical history of cardiovascular disease, cancer, diabetes or chronic diseases BMI < 18.5 OR > 30 kg/m^2 waist hip ratio > 0.9 total cholesterol > 5.2 mmol/L triacylglycerol (TAG) > 2.2 mmol/L current use of antihypertensive or lipid lowering medication

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: palm olein<br> | Dietary Supplement: The acute effects of dietary fat on lipid profile, insulin sensitivity and inflammatory markers<br> <br> |
| Experimental: olive oil<br> | Dietary Supplement: The acute effects of dietary fat on lipid profile, insulin sensitivity and inflammatory markers<br> <br> |
| Experimental: lard<br> | Dietary Supplement: The acute effects of dietary fat on lipid profile, insulin sensitivity and inflammatory markers<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Triacylglycerol (TAG) |  | 4 h | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Insulin sensitivity (glucose, insulin), non-esterified fatty acids (NEFA), inflammatory markers |  | 4 h | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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fat, inflammation, lipids, total cholesterol, Triglycerides, insulin sensitivity