Muscle Assessment in Women Who Have Undergone Roux-en-Y Gastric Bypass Surgery

Study Overview
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Brief Summary
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The purpose of this study is to assess muscle function in women at least two years after being submitted to Roux-en-Y Gastric Bypass Surgery and compare with a control group

Detailed Description
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Obesity is a public health problem globally. According to the World Health Organization (WHO) estimated are 600 million obese worldwide and according to National Health Survey 2010 in Chile 67% of the population suffers from some degree of overweight having approximately 300,000 morbidly obese. The first-line treatment for obesity is diet, exercise and cognitive behavioral therapy, however, these interventions are not effective enough to control long-term obesity, and so bariatric surgery is currently the treatment of choice to control morbid obesity. Overall, after bariatric surgery, most patients lose on average 60% of excess weight and improve their comorbidities during the first postoperative year, however, the long term effects of this weight reduction are not known in detail regarding body composition and muscle function. The aim of this study is to assess muscle function measured by hand grip strength test in women at least 2 years after bariatric surgery (Roux-en-Y Gastric Bypass) and to compare with control group.

Official Title
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Assessment of the Muscle Function Test in Women Who Have Undergone Roux-en-Y Gastric Bypass Surgery

Conditions
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Muscle Function, Handgrip Strength Test

Intervention / Treatment
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* Other: Assess muscle function


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Case group: women, 18-70 y, submitted to a Roux-en-Y Gastric Bypass Surgery at least two years ago Exclusion Criteria: osteoarthritis of hands and knees, any osteoarticular, rheumatologic or neurological disease hindering the performance of the tests of muscle function; type 2 diabetes mellitus; acute infectious diseases; use of muscle relaxants; physical and intellectual disabilities and uncontrolled hypothyroidism.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Bariatric surgery<br>Women who have been submitted to a Roux-en-Y Gastric Bypass Surgery for at least 2 years | Other: Assess muscle function<br>* Assess muscle function with hand grip test and sit and stand test<br>|
| Unoperated<br>Women with similar characteristics to control group (age, body mass index, physical activity level), but they have not been submitted to bariatric surgery | Other: Assess muscle function<br>* Assess muscle function with hand grip test and sit and stand test<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Handgrip strength | Assess handgrip test with a Jamar® hydraulic hand dynamometer | One time (initial assesment) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sit and stand | Number of repetitions of sit ups within 30 seconds | One time (initial assesment) | 
| Physical Activity Level | Assessment with International Physical Activity Questionnaires (IPAQ) | One time (initial assesment) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Bariatric surgery, sarcopenia