Minocycline in Patients With Huntington's Disease

Study Overview
=================
Brief Summary
-----------------
This is a study to determine whether treatment with minocycline is safe and tolerable in patients with Huntington's disease (HD) and whether minocycline reduces symptoms of HD in these patients.

Detailed Description
-----------------
Huntington's disease (HD) is a dominantly inherited disorder. It is uniformly progressive and there is no known effective treatment or cure. The pathogenesis is largely unknown; however, recent studies implicate caspase activation, glutamate excitotoxicity, and free radical toxicity as possible causes of HD. Pharmacological agents that block these pathways may be therapeutic in HD. Minocycline is an antibiotic that also inhibits caspase-1 and caspase-3 expression, and inducible nitric oxide synthetase activity, which are factors that may play an important role in the mechanisms of neuropathology in HD. Two dosages of minocycline or placebo will be given to ambulatory patients with HD over an 8-week period and the tolerability will be compared. Additional measures of safety and the change in motor, behavior, cognitive, and function features will be examined.

Official Title
-----------------
Minocycline Dosing and Safety in Huntington's Disease

Conditions
-----------------
Huntington's Disease

Intervention / Treatment
-----------------
* Drug: Minocycline


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Clinical features of Huntington's disease (HD) and a confirmatory family history of HD and/or a CAG repeat expansion of at least 37 Stage I, II, or III of illness (TFC greater than or equal to 5) Ambulatory and not requiring skilled nursing care Patients must use effective birth control Concurrent psychotropic medications must be at stable dose for at least 4 weeks prior to study WBC count at least 3,800/mm3 Creatinine no greater than 2.0 Alanine aminotransferase (ALT) no greater than 2 times upper limit of normal Exclusion criteria: Prior minocycline use within 2 months of baseline visit History of known sensitivity or intolerability to minocycline or any other tetracycline History of vestibular disease Use of any investigational drug within 30 days of baseline visit Treatment with any drug that may cause lupus-like symptoms (e.g., procainamide or hydralazine) within 4 weeks of baseline visit Pregnant or nursing Underlying hematologic, hepatic, or renal disease Evidence of unstable medical illness Illness that requires use of coumadin Unstable psychiatric illness defined as psychosis (hallucinations or delusions), untreated major depression within 90 days of baseline visit, or suicidal ideation Substance (alcohol or drug) abuse within 1 year of baseline visit History of systemic lupus erythematosis (SLE) or a history of SLE in a first-degree relative Positive ANA screening (at or above 1:80)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Minocycline|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Tetracyclines, Dose-Response Relationship, Drug