linjc16/ctgov huggingface dataset:
Interventions to Improve HIV Care Engagement After Hospital Discharge

Study Overview
=================
Brief Summary
-----------------
A quasi-experitmental study of the efficacy interventions, including additional HIV care team daily inpatient round and three telephone calls to remind the upcoming clinic appointment, in improving HIV care engagement within 30 days after hospital discharge among HIV-infected patients.

Official Title
-----------------
Interventions to Improve HIV Care Engagement Within 30 Days After Hospital Discharge Among HIV-infected Patients

Conditions
-----------------
HIV/AIDS

Intervention / Treatment
-----------------
* Other: Strategies to improve HIV care engagement


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: HIV-infected patients hospitalized at Thammasat University Hospital during the study period Exclusion Criteria: The patients who die during admission, are readmitted prior to 30 days after discharge or with incomplete data Readmission episodes of the same enrolled patients during the study period

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Interventions<br>Additional HIV care team daily inpatient round and three telephone calls to remind the upcoming clinic appointment. These interventions are specifically added on routine care during the post-intervention period. The routine care does not include the additional round and the three telephone calls and is assessed during the pre-intervention period. | Other: Strategies to improve HIV care engagement<br>* Additional HIV care team daily inpatient round and three telephone calls to remind the upcoming clinic appointment. These interventions are specifically added on routine care during the post-intervention period. The routine care does not include the additional round and the three telephone calls and is assessed during the pre-intervention period.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of HIV-infected patients who come to the designated HIV clinic for follow-up within 30 days after hospital discharge divided by the total number of enrolled HIV-infected patients |  | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Factors associated with no follow-up withing 30 days after hospital discharge(analyzed in multivariable logistic regression) |  | 30 days |
Spike-specific Cellular Immune Response After COVID-19 Vaccination

Study Overview
=================
Brief Summary
-----------------
Aim of this study is to evaluate whether COVID-19 vaccination induces a persistent cellular immune response. To this aim, blood samples are taken from vaccinated individuals and not immunized subjects as a control group. Cells isolated from blood samples are tested in vitro to assess the percentage of spike-specific T and B lymphocytes 1 and 7 months after a second dose of Comirnaty vaccine.

Detailed Description
-----------------
After providing written informed consent, 28 vaccinated and 25 non vaccinated subjects were included in the study. All subjects were enrolled among healthcare workers in the Research Centre of IRCCS San Raffaele Roma in Rome. All the subjects declared that they never tested positive for COVID19. Blood and serum samples were drowned twice from vaccinated subjects: 1 and 7 months after a second dose of vaccine to evaluate T and B response to vaccine; blood was drowned once in not vaccinated subjects. Cells were collected form peripheral blood samples, while anti-S1 IgG titre was assessed in serum. Flow-cytometry was used to assess the percentage of circulating spike-specific T and B lymphocytes.

Official Title
-----------------
Spike-specific Cellular Immune Response After COVID-19 Vaccination

Conditions
-----------------
COVID19, Vaccination, Immune Response

Intervention / Treatment
-----------------
* Other: analysis of immunological response
* Diagnostic Test: analysis of serum antibodies


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: vaccinated and non vaccinated subjects subjects that never tested positive for COVID19 Exclusion Criteria: subjects that tested positive for COVID-19

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| vaccinated<br>COVID19 vaccinated subjects | Other: analysis of immunological response<br>* collection and analysis of SARS-CoV2 Spike specific blood cells<br>Diagnostic Test: analysis of serum antibodies<br>* analysis of anti-SARS-CoV2 Spike specific antibodies<br>|
| non vaccinated<br>COVID19 non vaccinated subjects | Other: analysis of immunological response<br>* collection and analysis of SARS-CoV2 Spike specific blood cells<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| measurement of cellular response | evaluation of the increase of Spike-specific B and T cells percentage after COVID-19 vaccination | 7 months |
Nationwide Results on Chronic Pain After Bilateral Transabdominal Preperitoneal Inguinal Hernia Repair (TAPP)

Study Overview
=================
Brief Summary
-----------------
Danish male patients who had undergone bilateral TAPP (July 2012 to June 2013) were recruited from the Danish Hernia Database and cross-checked with hospital files and the National Patient Registry. A standardized postal questionnaire was sent out two years after the index surgery to investigate Patients Related Outcome Measures (PROMs) such as chronic post-operative pain.

Detailed Description
-----------------
The present study was primarily undertaken to provide evidence for the risk of activity-related chronic postoperative inguinal pain following bilateral TAPP in an all-male Danish setting. Impaired sexual activity and sleep disturbance due to pain was also recorded. Data based on nationwide consecutive patients undergoing bilateral TAPP. Data collected for the Danish Inguinal Hernia Database, hospital files and the National Patient Registry (Denmark).

Official Title
-----------------
Nationwide Results on Chronic Pain After Bilateral Transabdominal Preperitoneal Inguinal Hernia Repair (TAPP)

Conditions
-----------------
Hernia, Inguinal, Chronic Pain

Intervention / Treatment
-----------------
* Other: no intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Danish males, Age>18 years Elective, bilateral TAPP due to inguinal hernia within the period from July 1, 2012 to June 30 2013 Exclusion Criteria: age <18 years miss-classified surgical code non-Danish speaking psychiatric anamneses regarded and non-compliant patients who had either died, emigrated or were lost to follow-up emergency repair femoral hernia repair

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: no intervention|no intervention|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Activities Assessment Scale Questionnaire | Impaired daily activities by chronic pain from either one or both groin areas | Within one week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Questionnaire about sexual impairment | Sexual impairment due to chronic pain from either one or both groin areas | Within three months | 
| Questionnaire about sleep impairment | Sleep impairment due to chronic pain from either one or both groin areas | Within three months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Inguinal hernia
Acute Coronary Syndome With ST Elevation in Northern Lorraine

Study Overview
=================
Brief Summary
-----------------
Lorraine is one of the most affected French region by cardiovascular diseases with a mortality rate for ischemic heart disease higher than the national average in 2010. Due to practice change with the new recommandations of the European Society of Cardiology involving the myocardic revascularization, the investigators wanted to compare the Stemi care in 2005-2006, 2010-2011 and 2015 in the CHR Metz-Thionville.

Detailed Description
-----------------
This monocentric study evaluate the impact of the new recommandations of the European Society of Cardiology in the acute coronary syndrome with ST elevation (Stemi) care. Data is compiled retrospectively from angiographic report and informatic medical record.

Official Title
-----------------
Acute Coronary Syndrome With ST Elevation in Northern Lorraine: Evolution of Clinicals, Epidemiological and Angiographic Data Since 2005

Conditions
-----------------
Acute Coronary Syndrome

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient with an acute coronary syndrome with ST elevation for less than 12 hours Patients with coronarography in a context of cardiorespiratory arrest with unknown cause and acute coronary occlusion Exclusion Criteria: -
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acute coronary syndrome with ST elevation care | Percentage of per-cutaneous angioplasty and percentage of pre-hospital thrombolysis | Day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Stenting procedure | Percentage of manual thrombectomy and percentage of direct stenting | Day 1 | 
| Hospital mortality | Percentage of death during the STEMI care | Day 1 | 
| Epidemiology data | Mean age of STEMI patients | Day 1 |
Simplified Medical Abortion Follow-Up

Study Overview
=================
Brief Summary
-----------------
The purpose of this operations research study is to evaluate women's interest in and compliance with using a semiquantitative multi-level dipstick pregnancy test at home for medical abortion follow-up.

Official Title
-----------------
Simplified Medical Abortion Follow-Up Study

Conditions
-----------------
Abortion, Pregnancy Tests

Intervention / Treatment
-----------------
* Behavioral: Home-based follow-up with SQPT


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: She has been determined by the site investigator or designee to be fully eligible for medical abortion with mifepristone followed by misoprostol according to the site's standard criteria; She is willing to use the semiquantitative pregnancy test at home; She is wiling and able to comply with the study procedures; She speaks and reads English; She has signed the study informed consent form.

Ages Eligible for Study
-----------------
Minimum Age: 11 Years
Maximum Age: 56 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Home-based follow-up with SQPT<br>For the intervention, a semiquantitative pregnancy test (SQPT) will be performed at the health center before the participants take mifepristone, and again two weeks later by the participants, at home. Study staff will call the participants at two weeks to follow-up with the participants. | Behavioral: Home-based follow-up with SQPT<br>* Participants will be followed-up at home. They will receive an SQPT to perform at home two weeks after enrollment, and a scheduled follow-up phone call by study providers to determine the outcome of the procedure.<br>* Other names: Simplified Medical Abortion Follow-Up Study;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patients' compliance in performing the semiquantitative pregnancy test and reporting results | This will be assessed with a survey administered at the scheduled follow-up phone call. The survey will determine if the patient performed the SQPT as requested, and whether they can interpret and report the results correctly. | Within 2 weeks after medical abortion | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Medical abortion, pregnancy tests
Tracheal Mechanics During Bronchoscopy

Study Overview
=================
Brief Summary
-----------------
The main purpose of this study is use a new type of measurement to help decide what kind of therapy would help people with a collapsing windpipe or tracheomalacia.

Detailed Description
-----------------
This study is to obtain new information about the pressures required to collapse the trachea in patients with and without obstructive pulmonary disease and to describe the relationship between pressures and airflow obstruction. This information will provide normative data not currently available and would establish whether tracheal collapse is due to tracheomalacia. The data may lead to better ways of predicting if a patient would benefit from procedures to prevent tracheal collapse.

Official Title
-----------------
Tracheal Mechanics During Bronchoscopy

Conditions
-----------------
Tracheomalacia, Tracheobronchomalacia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Suspicion of tracheal collapse undergoing bronchoscopy Healthy control subject undergoing bronchoscopy for another purpose. Exclusion Criteria: Esophageal pathology Tracheostomy inability to follow commands

Ages Eligible for Study
-----------------
Minimum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COPD<br>Patients with cough and/or shortness of breath who may have windpipe collapse. | |
| Healthy adults<br>Subjects without symptoms for comparison. | |
| Tracheomalacia<br>Patients with cough and/or shortness of breath who may have windpipe collapse. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
COPD
Effect of Calling the Patient's Name on Recovery From General Anesthesia

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to find if we can shorten the recovery time by calling the patient's name during anesthesia reversal.

Conditions
-----------------
Delayed Emergence From Anesthesia

Intervention / Treatment
-----------------
* Procedure: Calling the patient's name
* Procedure: Not calling the patient's name


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patient aged between 20-70 patient receiving breast cancer surgery under general anesthesia with total intravenous anesthesia using remifentanil and propofol, and intubated with LMA Exclusion Criteria: refusal of consent patients taking CNS stimulants general anesthesia with other agents than propofol and remifentanil intubated with other equipments than LMA chronic alcoholic patient patients with convulsive disorder

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Calling the patient's name<br>The anesthesiologist tries to recover the patient's consciousness by calling the patient's name | Procedure: Calling the patient's name<br>* calling the patient's name during anesthesia reversal<br>|
| Experimental: Not calling the patient's name<br>The anesthesiologist tries to recover the patient's consciousness by giving verbal stimulus other than the patient's name | Procedure: Not calling the patient's name<br>* giving verbal stimulus other than the patient's name during anesthesia reversal<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in recovery time between the two groups | difference in recovery time (eye opening time, extubation time) after stopping injection of anesthetics, and the time when the patient's bispectral index value displayed on the monitor is above 60 | 1 min,2 min,3 min, 4min, 5min, 6min, 7min, 8min, 9min, 10min after stopping injection of anesthetics |
The Effect of Esophageal Doppler Guided Goal-directed Hemodynamic Therapy in Severe Trauma Patients

Study Overview
=================
Brief Summary
-----------------
Prospective randomized clinical trial Compare the goal-directed fluid therapy using esophageal Doppler and classic fluid therapy

Detailed Description
-----------------
Goal directed fluid therapy becomes issue for enhanced recovery after surgery. In goal directed therapy, dynamic parameters, like stroke volume and cardiac output, is important. Esophageal Doppler is one of device which provides dymanic parameters. In severe trauma cases, the effect of goal directed therapy is not known yet. So the aim of this study is comparing the results of goal directed therapy using esophageal Doppler and conventional fluid therapy.

Official Title
-----------------
The Effect of Esophageal Doppler Guided Goal-directed Hemodynamic Therapy

Conditions
-----------------
Trauma

Intervention / Treatment
-----------------
* Device: esophageal Doppler


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Severe trauma patients who undergo general anesthesia Initial serum lactate level > 2mmol/L Exclusion Criteria: Severe traumatic brain injury THoracic surgery Age < 19 years old Impending arrest or post CPR state Severe facial trauma

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| control<br>Monitoring arterial pressure, central venous pressure and pulse pressure variation | |
| esophagela Doppler<br>Monitoring arterial pressure, central venous pressure Insertion of esophageal Doppler probe to patient Monitoring stroke volume, cardiac output, corrected flow time from esophageal Doppler Use stroke volume optimization goal directed therapy protocol | Device: esophageal Doppler<br>* Goal directed fluid therapy using dynamic parameters from esophageal Doppler<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lactate | Unit is mmol/L Inclusion criteria is initial lactate > 2mmol/L. Whole hospital use same device and unit to measure lactate. In this study, POCT lactate won't be used. After surgical resuscitation, lactate level is independent predictor of survival, because it represents tissue oxygenation. | Immediate postoperative (=initial ICU admission) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acute Physiology and Chronic Health Evaluation II (APACHE II) score | ICU patient scoring system, score from 0 to 71, higher scores correspond to more severe disease and a higher risk of death | Immediate postoperative | 
| Creatinine | Kidney function | Immediate postop |
Study of Opioid Immunosuppressive Effects

Study Overview
=================
Brief Summary
-----------------
This trial aims to investigate the effects of opioid-inducing immune suppression on opioid drug abused patients. The methods of the investigators research mainly includes the expression of morphine-related miRNAs in peripheral blood mononuclear cells and cytokine in plasma.

Conditions
-----------------
Opioid Abuse or Dependence

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: subjects were excluded if they had a chronic systemic illness (cardiac, renal, pulmonary, hepatic, endocrine, metabolic, or autoimmune disorders) or a major psychiatric disorder or if they were abusing substances other than heroin (as determined by urine drug test result). For women, pregnancy was also a reason for exclusion. Exclusion Criteria: Control subjects with no history of drug or alcohol abuse were also excluded if they had major medical or psychiatric disorders

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| morphine or heroin dependence patients<br> | |
| normal control group<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| real-time quantitative polymerase chain reaction |  | up to 2 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| enzyme-linked immuno sorbent assay |  | up to 2 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Opioid drug Abuse, Morphine, Immune Function