Effects of an Amino Acid and Chromium-picolinate Containing Drink on Glucose Metabolism on Healthy Subjects

Study Overview
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Brief Summary
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It has previously been shown in healthy overweight subjects, that table water including a defined amount of amino acids and chromium can decrease the postprandial glucose. In this study, the effect of this table water on glucose excursions after a test meal containing a defined amount of available carbohydrates, protein and fat will be studied in healthy subjects. The study will be conducted in a cross -over design, double blinded and placebo controlled including 20 participants. The primary endpoint of the study is the incremental area under the curve for plasma glucose (iAUCgluc) within 180 minutes after ingestion of the meal.

Official Title
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Effect of a Table Water Enriched With Amino Acids and Chromium on Blood Glucose and Insulin Levels After a Meal

Conditions
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Diabetes

Intervention / Treatment
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* Dietary Supplement: Amino Acids and chromium-picolinate containing drink
* Dietary Supplement: Placebo drink


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Stable body weight (no changes above 3 kg during the last 2 months) Good general health Body mass index 19 - 30 kg/m2 (normal to overweight) Fasting blood glucose below 6.1 mmol/L Exclusion Criteria: Any medication that could influence the study. Such as medication against diabetes, hypoglycemia, hypertension or hypercholesterolemia Psychiatric Disease Alcohol or drug abuse Smokers or people consuming snus Acute infections Vegetarians/vegans Suffering from Lactose or Gluten intolerance Pregnancy or Lactation Participation in another study at the same time Any other parameter that the PI will judge as inadequate

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Breakfast meal<br>A breakfast like meal will be provided together with a drink to overnight fasted subjects | Dietary Supplement: Amino Acids and chromium-picolinate containing drink<br>* Evaluation of the dietary supplement drink containing amino acids and chromium picolinate and aroma<br>Dietary Supplement: Placebo drink<br>* Evaluation of the placebo supplement drink containing only aroma<br>|
| Experimental: Lunch meal<br>A lunch like meal will be provided together with a drink to overnight fasted subjects | Dietary Supplement: Amino Acids and chromium-picolinate containing drink<br>* Evaluation of the dietary supplement drink containing amino acids and chromium picolinate and aroma<br>Dietary Supplement: Placebo drink<br>* Evaluation of the placebo supplement drink containing only aroma<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Area under the curve for Glucose after ingestion of a test meal |  | 180 min | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Area under the curve for insulin after ingestion of a test meal |  | 180 min |