Effect Of Non-Surgical Periodontal Treatment On Lipoxin a4 Levels

Study Overview
=================
Brief Summary
-----------------
The aim of this study was to evaluate the levels of lipoxin A4 (LXA4), prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) in gingival crevicular fluid (GCF) and saliva in individuals with periodontal healthy and chronic periodontitis. In addition, the investigators evaluated the levels of these mediators after non-surgical periodontal treatment in patients with chronic periodontitis. A total of 20 subjects, 10 patients with chronic periodontitis (CP) and 10 periodontally healthy individuals were included in the study. Clinical parameters including plaque index (PI), gingival index (GI), probing depth (PD) and clinical attachment levels (CAL) were recorded. GCF and saliva samples were obtained at the beginning of the study from all individuals. GCF and saliva samples were re-collected from patients with CP at 1 month after non surgical periodontal therapy.

Official Title
-----------------
Effect Of Non-Surgical Periodontal Treatment On Endogenous Anti-Inflammatory Lipid Mediators In Patients With Chronic Periodontitis

Conditions
-----------------
Periodontitis

Intervention / Treatment
-----------------
* Procedure: Non-surgical periodontal treatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Have at least 20 natural teeth, excluding third molars. Chronic periodontitis patients had at least two non-adjacent sites per quadrant with probing depth (PD) ≥ 5 mm and clinical attachment level (CAL) ≥ 5 mm with gingival inflammation, and alveolar bone loss affecting >30% of the teeth, as detected on clinical and radiographical examinations. Periodontally healthy control group had no sign of gingival inflammation, no PD > 3mm and no evidence of attachment or bone loss. Exclusion Criteria: History of systemic disease. Regular use of any drugs which can effect the immune system or inflammatory response in the 6 months preceding the start of the study. Periodontal treatment during last 6 months that could affect periodontal status. Smoking. History of radiotherapy or chemotherapy. Ongoing orthodontic treatment. Aggressive periodontitis. Current pregnancy, lactation or menopause.

Ages Eligible for Study
-----------------
Minimum Age: 25 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control<br>Periodontally healthy group | |
| Experimental: Chronic Periodontitis<br>Patients with chronic periodontitis | Procedure: Non-surgical periodontal treatment<br>* Mechanical non-surgical treatment were performed<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lipoxin A4 levels | change of gingival crevicular fluid and salivary Lipoxin A4 levels from baseline at 1st month | 1st month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prostaglandin E2 levels | change of gingival crevicular fluid and salivary Prostaglandin E2 levels from baseline at 1st month | 1st month | 
| Leukotriene B4 | change of gingival crevicular fluid and salivary Leukotriene B4 levels from baseline at 1st month | 1st month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Gingival Crevicular Fluid, Lipid Mediator, Periodontal Treatment