The Effects of Mood on Cerebral Perfusion

Study Overview
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Brief Summary
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Measuring brain perfusion is biased by a inter- and intrasubject variability, caused by physiological and lifestyle factors. In this study, the investigators want to investigate the effects of a different mood state (neutral, positive and negative mood), induced using subjects own memories, on both global and regional cerebral perfusion, measured with arterial spin labeling.

Official Title
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The Effects of Mood on Cerebral Perfusion

Conditions
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Cerebral Perfusion

Intervention / Treatment
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* Behavioral: Mood induction (using own memories)
* Device: Arterial spin labeling MRI
* Device: Physiological monitoring


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy university students between 18 and 30 years old Exclusion Criteria: No informed consent Not using hormonal contraception MRI-contraindications Claustrophobia Pregnancy Chronic diseases and chronic medication use

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Imaging healthy volunteers<br>Mood induction: positive, negative, neutral mood (using subjects own memories) Arterial spin labeling MRI Physiological monitoring | Behavioral: Mood induction (using own memories)<br>* Subjects deliver three positive, three negative and three neutral memories 30 seconds reliving a memory - answering questions about the memory - reliving memory for 2 minutes during ASL-MRI<br>Device: Arterial spin labeling MRI<br>* Single PLD PCASL<br>Device: Physiological monitoring<br>* During MRI: heart rate, end-tidal CO2, respiratory rate and skin conductance<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Regional Cerebral perfusion (ml/100g/min) during positive mood induction | Effect of positive mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI. | 2 minutes (ASL scan during mood state induction) | 
| Regional Cerebral perfusion (ml/100g/min) during negative mood induction | Effect of negative mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI. | 2 minutes (ASL scan during mood state induction) | 
| Regional Cerebral perfusion (ml/100g/min) during neutral mood induction | Effect of neutral mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI. | 2 minutes (ASL scan during mood state induction) | 
| Regional Cerebral perfusion (ml/100g/min) after positive mood induction | Effect of positive mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI. | 2 minutes (ASL scan after mood state induction) | 
| Regional Cerebral perfusion (ml/100g/min) after negative mood induction | Effect of negative mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI. | 2 minutes (ASL scan after mood state induction) | 
| Regional Cerebral perfusion (ml/100g/min) after neutral mood induction | Effect of neutral mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI. | 2 minutes (ASL scan after mood state induction) |