Usage of Multiple Drugs in Treatment of Postoperative Vomiting After Laparoscopic Appendectomy

Study Overview
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Brief Summary
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To compare and evaluate the antiemetic effect and the safety of ondansetron, inhalational isopropyl alcohol and super hydration on adult patients after laparoscopic appendectomy.

Detailed Description
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This prospective double-blind study done on 240 patients admitted to surgical I.C.U after laparoscopic appendectomy. Those who had preoperative Koivuranta vomiting score of more than 3 enrolled in our study. Every group contains 80 patients. Patients of group A received ondansetron 4 mg intravenous immediately once reached to I.C.U and another same dose after 6 hours while patients of group B received isopropyl alcohol 70% inhalation every 15 min for 4 times then repeated after 6 hours. The last group C received intravenous normal saline at rate of 20 ml/kg over 30 minute and repeated by the same dose after 6 hours. The duration of the study was 24 hours post-operatively. As PONV is self-limited within 24 hours.

Official Title
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Comparative Study Between Ondansetron, Isopropyl Alcohol Inhalation and Super Hydration in Treatment of Postoperative Emesis After Laparoscopic Appendectomy

Conditions
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to Treat the Vomiting Frequently Occur Post-laparoscopic by Different Anti Emetic Drugs

Intervention / Treatment
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* Drug: Ondansetron
* Drug: isopropyl alcohol 70% inhalation
* Procedure: laparoscopic appendectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: postoperative nausea and vomiting Exclusion Criteria: systemic disease as diabetes or hypertension local gastric diseases

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group A<br>received ondansetron 4 mg intravenous immediately once reached to I.C.U and another same dose after 6 hours | Drug: Ondansetron<br>* ondansetron 4 mg intravenous immediately once reached to I.C.U and another same dose after 6 hours while patients of group<br>Procedure: laparoscopic appendectomy<br>* all patients received post operatively after laparoscopic appenectomy<br>|
| Group B<br>received isopropyl alcohol 70% inhalation every 15 min for 4 times then repeated after 6 hours | Drug: isopropyl alcohol 70% inhalation<br>* inhalation every 15 min for 4 times then repeated after 6 hours<br>Procedure: laparoscopic appendectomy<br>* all patients received post operatively after laparoscopic appenectomy<br>|
| Group C<br>received intravenous normal saline at rate of 20 ml/kg over 30 minute and repeated by the same dose after 6 hours. | Procedure: laparoscopic appendectomy<br>* all patients received post operatively after laparoscopic appenectomy<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| numbers of vomiting attacks | numbers of vomiting attacks recorded every 15 minutes for one day | for one day |