Lanugo Hair Loss as a Marker for Peri-ocular Malignancy

Study Overview
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Brief Summary
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Skin cancers around the eye are common, but so are other lid lumps. It is useful to be able to tell which lumps are likely to be cancer. This study looks at whether the loss of fine hairs (lanugo hairs) on the skin are a good indicator of whether a lump is a skin cancer or not. The investigators are recruiting patients who have lid lumps who haven't had a biopsy before, who would be having a biopsy as part of their treatment, and seeing whether those who have loss of the fine skin hairs are the same as those who have skin cancer confirmed on their biopsy. The study doesn't involve any extra examinations or treatments for participants. The investigators look at the patients before the biopsy as part of their usual care, and take a note of whether or not they have lost the fine hairs at this stage. The main benefit of participating is that the medical community has better evidence about which lid lumps are likely to represent skin cancer, helping future diagnosis. There are no additional risks to participating. The risks of biopsy are unchanged whether patients participate in the study or not. The study is run from the Princess Alexandra Eye Pavilion in Edinburgh, in conjunction with Moorfields Eye Hospital, London The investigators aim to start the study in Spring 2018, and will most likely recruit for 6 months depending on the number of participants recruited. There is no additional funding from any source at present - the work will be undertaken by doctors in their research time.

Official Title
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Lanugo Hair Loss as a Marker for Peri-ocular Malignancy

Conditions
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Skin Cancer Face

Intervention / Treatment
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* Diagnostic Test: Examination for presence or absence of lanugo hairs


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients undergoing biopsy for peri-ocular lesion Exclusion Criteria: Age under 18; previous biopsy or excision on the same lid

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients undergoing biopsy<br>Patients undergoing biopsy (incisional or excisional) of peri-ocular lesions. Pre-operative examination for presence or absence of lanugo hairs | Diagnostic Test: Examination for presence or absence of lanugo hairs<br>* Pre-operative examination for presence or absence of lanugo hairs<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lanugo hair presence/absence | Examination for the presence or absence of lanugo hairs prior to biopsy | Examination on day of biopsy | 
| Biopsy result | Biopsy result looking for malignancy | Typically reported within a week of biopsy | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Peri-ocular