Effects of Exercise Intervention on Muscle Strength in Severely Ill Patients

Study Overview
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Brief Summary
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In recent years, due to the improvement in the survival rate of the intensive care unit, the problem of severe systemic fatigue (Intensive care unit acquired weakness; ICUAW) has continued to receive attention. Muscle mass decreases by 3-11% within a week, resulting in decreased muscle strength and muscle atrophy. Current studies suggest that ICUAW can lead to poorer function, prolonged ICU stay, and decreased quality of life. This study aimed to understand the muscle strength of critically ill patients and to explore the effect of exercise intervention on improving muscle strength. The experimental group received a four-week exercise bike intervention plus conventional rehabilitation exercises, while the control group received conventional rehabilitation exercises.

Detailed Description
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The content of the exercise is to use an exercise bike, start pedaling on the first day, time setting: 20 minutes, speed: 2, and adopt passive mode. If you can complete the exercise on the first day, the time will be adjusted to 30 minutes on the second day. If you cannot complete the exercise on the first day, the time will still start from 20 minutes on the second day. The maximum time is 30 minutes. If you can complete 30 minutes of passive exercise for 3 consecutive days, the fourth day will be adjusted to active exercise. The entire exercise training is seven days a week, once a day, once a 30-minute, at least 5 days. Those who were discharged to the general ward continued to complete this exercise training for up to 28 days. Stop exercising if heartbeat > 140, mean arterial pressure < 65, blood oxygen < 90%, respiration > 35 beats/min, or the patient requests to stop during exercise.

Official Title
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Effects of Exercise Intervention on Muscle Strength in Severely Ill Patients

Conditions
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Intensive Care Unit Patients

Intervention / Treatment
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* Other: exercise bike


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged over 20 years old Conscious willing to participate in this study, and signed the consent form no lower extremity activity taboo, and can walk independently before admission Exclusion Criteria: Have neuromuscular disease. Unable to step on a bed bike.

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: exercise bike<br>exercise is to use an exercise bike, start pedaling on the first day, time setting: 20 minutes, speed: 2, and adopt passive mode. If you can complete the exercise on the first day, the time will be adjusted to 30 minutes on the second day. If you cannot complete the exercise on the first day, the time will still start from 20 minutes on the second day. The maximum time is 30 minutes. If you can complete 30 minutes of passive exercise for 3 consecutive days, the fourth day will be adjusted to active exercise. The entire exercise training is seven days a week, once a day, once a 30-minute, at least 5 days. Those who were discharged to the general ward continued to complete this exercise training for up to 28 days. | Other: exercise bike<br>* exercise is to use an exercise bike, start pedaling on the first day, time setting: 20 minutes, speed: 2, and adopt passive mode. If you can complete the exercise on the first day, the time will be adjusted to 30 minutes on the second day. If you cannot complete the exercise on the first day, the time will still start from 20 minutes on the second day. The maximum time is 30 minutes. If you can complete 30 minutes of passive exercise for 3 consecutive days, the fourth day will be adjusted to active exercise. The entire exercise training is seven days a week, once a day, once a 30-minute, at least 5 days. Those who were discharged to the general ward continued to complete this exercise training for up to 28 days.<br>|
| No Intervention: regular rehabilitation exercises<br>walking exercise | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Basic Demographic Health Assessment Form | Age, sex, diagnosis, disease severity, reason for ICU admission | baseline | 
| days in intensive care unit | Health Assessment Form | baseline | 
| days on ventilator | Health Assessment Form | baseline | 
| total days in hospital | Health Assessment Form | baseline | 
| body mass index | Health Assessment Form | baseline | 
| level of albumin | Health Assessment Form | baseline | 
| The daily observation record sheet includes | Vital signs,respirator is used or not,bicycle use pattern,speed and time,reasons for stopping | up to 28 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hand grip strength | Using a Grip Strength Tester to Measure Dominant Hand Muscle Strength | baseline(T0) | 
| Hand grip strength | Using a Grip Strength Tester to Measure Dominant Hand Muscle Strength | 3 days after intervention(T1) | 
| Hand grip strength | Using a Grip Strength Tester to Measure Dominant Hand Muscle Strength | 7 days after intervention(T2) | 
| Hand grip strength | Using a Grip Strength Tester to Measure Dominant Hand Muscle Strength | 10 days after intervention(T3) | 
| Hand grip strength | Using a Grip Strength Tester to Measure Dominant Hand Muscle Strength | 14 days after intervention(T4) | 
| Hand grip strength | Using a Grip Strength Tester to Measure Dominant Hand Muscle Strength | 17 days after intervention(T5) | 
| Hand grip strength | Using a Grip Strength Tester to Measure Dominant Hand Muscle Strength | 21 days after intervention(T6) | 
| Hand grip strength | Using a Grip Strength Tester to Measure Dominant Hand Muscle Strength | 28 days after intervention(T7) | 
| foot lift | Use a tape to measure foot lift | baseline(T0) | 
| foot lift | Use a tape to measure foot lift | 3 days after intervention(T1) | 
| foot lift | Use a tape to measure foot lift | 7days after intervention(T2) | 
| foot lift | Use a tape to measure foot lift | 10days after intervention(T3) | 
| foot lift | Use a tape to measure foot lift | 14days after intervention(T4) | 
| foot lift | Use a tape to measure foot lift | 17ays after intervention(T5) | 
| foot lift | Use a tape to measure foot lift | 21days after intervention(T6) | 
| foot lift | Use a tape to measure foot lift | 28days after intervention(T7) | 
| walking distance in 6 minutes | Measure 6-minute walking distance | baseline(T0) | 
| walking distance in 6 minutes | Measure 6-minute walking distance | 3 days after intervention(T1) | 
| walking distance in 6 minutes | Measure 6-minute walking distance | 7 days after intervention(T2) | 
| walking distance in 6 minutes | Measure 6-minute walking distance | 10days after intervention(T3) | 
| walking distance in 6 minutes | Measure 6-minute walking distance | 14days after intervention(T4) | 
| walking distance in 6 minutes | Measure 6-minute walking distance | 17days after intervention(T5) | 
| walking distance in 6 minutes | Measure 6-minute walking distance | 21days after intervention(T6) | 
| walking distance in 6 minutes | Measure 6-minute walking distance | 28ays after intervention(T7) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Intensive care unit patients, exercise Training