The Intersectional Viborg Screening Program: Cost-(Effectiveness) of Screening for Diabetes and Cardiovascular Diseases

Study Overview
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Brief Summary
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This is an intersectional and interdisciplinary screening program in Viborg Municipality, including 67 years old citizens. This observational study will estimate the cost-effectiveness of a combined screening program for the following conditions: Abdominal aortic aneurysm, peripheral arterial disease, carotid plaque, hypertension, arrhythmia, and type-2-diabetes. Furthermore, the incidence of the outlined conditions will be described and so will the result of the intervention initiated (secondary medical prophylaxis, smoking cessation, introduction to nutritionally deficient diet etc.)

Detailed Description
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Description of the cohort: All Viborg municipality citizen are invited to the combined screening program around there 67th birthday. Participants with positive screening results are offered following up consultations and prophylactic interventions are initiated (secondary medical prophylaxis, smoking cessation, introduction to nutritionally deficient diet etc.) 67 years-old citizens from the surrounding municipalities without the offer of the combined screening are used as a control group (1 case: 5 controls). There are no exclusion criteria. The screening examination includes: Blood pressure in both arms, ankle brachial blood pressure index (ABI), ultrasound for carotid plaque and abdominal aortic aneurysm, HbA1c and pulmonary function test. Furthermore, a questionnaire on lifestyle parameters, BMI, medical history, walking-related pain and self-rated quality of life (EQ-5D). One year after the screening examination, the participants will receive a questionnaire in order to evaluate the effect from a participant perspective. The cost(-effectiveness) of the screening program will be estimated after 5 years based on prevalence of diseases, response rate, data extraction from nationwide registries and existing evidence of disease prevention.

Official Title
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Intersectional Screening Program for Diabetes and Cardiovascular Diseases Among 67-years Old Citizens of the Municipal of Viborg

Conditions
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Arrythmia, Aging, Aortic Aneurysm, Abdominal, Hypertension, Mass Screening, Peripheral Arterial Disease, Diabetes, Carotid Atherosclerosis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All Viborg municipality citizen are invited to the combined screening program around there 67th birthday. Exclusion Criteria: There are no exclusion criteria.

Ages Eligible for Study
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Minimum Age: 67 Years
Maximum Age: 67 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Baseline prevalence of peripheral arterial disease (PAD) in men and women aged 67 years from a population screening study on the Municipal of Viborg. | Ankel Brachial Index | Inclusion will take place from sep. 2014 to sep. 2020 | 
| Baseline prevalence of abdominal aortic aneurysm (AAA) | Ultra sound examination (AP diameter (mm)) | Inclusion will take place from sep. 2014 to sep. 2020 | 
| Baseline prevalence of diabetes | Bedside HbA1c | Inclusion will take place from sep. 2014 to sep. 2020 | 
| Baseline prevalence of hypertension | BP(mmhg) | Inclusion will take place from sep. 2014 to sep. 2020 | 
| Baseline prevalence of cardiac arrythmia | ECG | Inclusion will take place from sep. 2014 to sep. 2020 | 
| Baseline prevalence of carotic plaques | Ultra sound examination of A. carotis (IMT in mm) | Inclusion will take place from sep. 2014 to sep. 2020 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The cost(-effectiveness) of the screening program | Socio-economic evaluation (national register data), QALY | 5 years after ending inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Mass screening, cardiovascular disease, diabetes