Observing the Perioperative Effects of Prehabilitation in Colorectal Cancer Patients

Study Overview
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Brief Summary
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Quality Improvement Project to evaluate how prehabilitation can be incorporated into our colorectal cancer pathway and assess its clinical benefits.

Detailed Description
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The aim was to evaluate how prehabilitation (PH) can be incorporated into our colorectal cancer pathway and assess its clinical benefits. Patients underwent PH (exercise, nutrition and psychological support) before resection of colorectal carcinoma in a DGH over fourteen months. Patients were matched by operation, age, sex and ASA to non-prehabilitation (NPH) patients using a prospectively maintained database. Length of stay (LoS) and complication rate and 90-day readmission rates were compared using Wilcoxon and McNemar's methods. Prehabilitation significantly improved peak VO2 and AT. This corresponds to a reduction in predicted 30-day mortality. Despite a higher Charlson index LoS was unchanged suggesting prehabilitation may permit safe resection in comorbid patients.

Official Title
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Observing the Perioperative Effects of Prehabilitation in Colorectal Cancer

Conditions
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Colon Cancer

Intervention / Treatment
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* Other: Prehabilitation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adults over the age of 18 who had prehabilitation for colorectal cancer Exclusion Criteria: Children Patients who had prehabilitation but not for colorectal cancer

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Prehabilitation (PH)<br>Patients who underwent prehabilitation prior to colorectal cancer resection | Other: Prehabilitation<br>* Prehabilitation is a multimodal and multidisciplinary person-centred perioperative approach involving supervised exercise training, nutritional education, management of polypharmacy and psychological advice.<br>|
| Non-Prehabilitation (NPH)<br>Patients who did not undergo prehabilitation prior to colorectal cancer resection | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of stay | Time spent in hospital | From date of operation to date of discharge in number of days over a 90 day follow up period | 
| Complication rate | All Clavien-Dindo complications | Follow up over a period of 90 days following operation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anaerobic threshold | Measured by looking at CPET results pre- and post- prehab | CPET performed before prehabilitation and after prehabilitation (median of 36 days) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Prehabilitation