Clinical Indicators and Brain Image Data: a Study Based on Kailuan Cohort

Study Overview
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Brief Summary
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The investigators will analyze the relationship between the medical history, physiological indicators and the cerebral small vessel disease as well as the structural and functional changes of the brain/head and neck organs in a large sample size of subjects (participants), to identify the influencing factors of the occurrence and development of cerebral small vessel disease as well as the structural and functional changes of the brain/head and neck organs, so as to provide objective clues for early intervention of the disease and improve clinical outcomes.

Official Title
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Clinical Indicators and Brain Image Data: a Cohort Study Based on Kailuan Cohort

Conditions
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Brain Diseases, Hypertension

Intervention / Treatment
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* Other: No intervention will be applied.


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age from 18 to 90 years old; Comes from the Kailuan Cohort, completed ≥1 visits which the medical history, physiological indicators were measured; Without contraindications of CT and MR scan; Can cooperate with the measurement of the medical history, physiological indicators and brain imaging. Exclusion Criteria: Known clinical history with congenital or acquired organic diseases (such as aortic stenosis); Known history of drug abuse; Pregnant and lactating women; 4. With clinical history of psychiatric diseases (such as schizophrenia).

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| subjects from Kailuan community<br>1. Age from 18 to 90 years old; 2. Comes from the Kailuan Cohort, completed ≥1 visits which the medical history, physiological indicators were measured; 3. Without contraindications of CT and MR scan; 4. Can cooperate with the measurement of the medical history, physiological indicators and brain imaging. Subjects with the following conditions should be excluded: 1. Known clinical history with congenital or acquired organic diseases (such as aortic stenosis); 2. Known history of drug abuse; 3. Pregnant and lactating women; 4. With clinical history of psychiatric diseases (such as schizophrenia). | Other: No intervention will be applied.<br>* This is an observational study.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| White matter hyperintensity of the brain measured by MRI (magnetic resonance imaging) |  | every two years up to 30 years | 
| microbleeds of the brain measured by MRI (magnetic resonance imaging) |  | every two years up to 30 years | 
| Lacunes of the brain measured by MRI (magnetic resonance imaging) |  | every two years up to 30 years | 
| Cerebral blood flow measured by MRI (magnetic resonance imaging) |  | every two years up to 30 years | 
| Brain volume measured by MRI (magnetic resonance imaging) |  | every two years up to 30 years | 
| White matter microstructural integrity of the brain measured by MRI (magnetic resonance imaging) |  | every two years up to 30 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| blood glucose level |  | every two years up to 30 years | 
| Cervical vascular ultrasound |  | every two years up to 30 years | 
| Fundus color photography of the eyes |  | every two years up to 30 years | 
| Fundus optical coherence tomography (OCT) |  | every two years up to 30 years | 
| Blood pressure (both Systolic and Diastolic Blood Pressure) |  | every two years up to 30 years | 
| BMI (body mass index) |  | every two years up to 30 years | 
| Uric acid |  | every two years up to 30 years |