Efficacy of Short-message-based Re-education (SMRE) on Helicobacter Pylori Eradication

Study Overview
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Brief Summary
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Helicobacter pylori (H. pylori) is a pathogen that infects more than 50% of the human population, resulting in high healthcare costs worldwide. However, H. pylori eradication rate is low nowadays and patients's compliance is one of the most important effective factors.

Official Title
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Efficacy of Short-message-based Re-education (SMRE) on Helicobacter Pylori Eradication

Conditions
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Helicobacter Pylori Eradication Rate

Intervention / Treatment
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* Behavioral: Short-message-based Re-education
* Behavioral: conventional education


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: outpatients aged 18-70 years confirmed diagnosis of H. pylori infection by at least one of the following methods: 13C-urea breath test, histology, rapid urease test or bacterial culture an intention of H. pylori eradication treatment and have written inform consent ability to read short messages on the mobile phone Exclusion Criteria: advanced chronic disease that would not allow the patient to complete the treatment or follow-up or attend visits allergy to any of the drugs used in this study previous Helicobacter Pylori eradication treatment pregnancy or breastfeeding (female participants with childbearing potential were required to use medically accepted contraception for the duration of the study) taking antibiotics or PPIs or bismuth salts within four weeks previous gastrointestinal surgery

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Short-message-based Re-education group<br>Patients receive oral and written education before H. pylori eradication therapy at first, then they receive short message re-education twice per day during therapy. Both the content of the oral and written education and the short message re-education are same. | Behavioral: Short-message-based Re-education<br> <br> |
| Active Comparator: conventional education group<br>Patients only receive oral and written education before H. pylori eradication therapy. | Behavioral: conventional education<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The difference of H. pylori eradication rate between two groups |  | 8 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of non-compliance with instructions between 2 groups |  | 8 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Helicobacter Pylori eradication rate, Efficacy of Short-message-based Re-education (SMRE)