Internet-delivered Psychodynamic Therapy for Depression and Anxiety Disorders

Study Overview
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Brief Summary
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The overall aim of this study is to develop and test a psychodynamic Internet-delivered psychological treatment for patients with major depression and/or anxiety disorders and compare its efficacy to an active control group.

Official Title
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Internet-delivered Psychodynamic Therapy for Depression and Anxiety Disorders: A Randomized Controlled Trial

Conditions
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Depression, Anxiety

Intervention / Treatment
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* Behavioral: Internet-delivered Psychodynamic Treatment
* Behavioral: Internet-delivered structured support


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical diagnosis of Major Depressive Disorder, Panic Disorder, Social Anxiety Disorder, Generalized Anxiety disorder, Depressive Disorder NOS or Anxiety Disorder NOS 10 or higher on the PHQ-9 or on the GAD-7 at pre-treatment Exclusion Criteria: Primary diagnosis of Obsessive Compulsive Disorder or Post-traumatic Stress Disorder Severe psychiatric condition (e.g. psychosis or bipolar disorder) Alcohol abuse (more than 16 on the AUDIT) Suicidal (measured in diagnostic interview) Changed medication during the last three months

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Internet-delivered Psychodynamic Treatment<br>Participants in the experimental condition will receive 8 text-modules delivered as guided self-help, via the Internet. The intervention lasts for 10 weeks and includes weekly contacts with a therapist via a secure online environment similar to e-mail. The treatment is a short-term psychodynamic treatment psychodynamic treatment. | Behavioral: Internet-delivered Psychodynamic Treatment<br>* Ten weeks of guided self-help + therapist contact, via the Internet.<br>|
| Active Comparator: Internet-delivered structured support<br>Participants in the active control condition will receive a structured support treatment via the Internet. The intervention lasts for 10 weeks and includes weekly contacts with a therapist via a secure online environment similar to e-mail. | Behavioral: Internet-delivered structured support<br>* Ten weeks of therapist contact, via the Internet.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 9-item Patient Health Questionnaire Depression Scale (PHQ-9) |  | Two weeks before the treatment starts | 
| 7-item Patient Health Questionnaire Generalized Anxiety Disorder Scale (GAD-7) |  | Two weeks before the treatment starts | 
| 9-item Patient Health Questionnaire Depression Scale (PHQ-9) |  | At treatment start (0 weeks) | 
| 7-item Patient Health Questionnaire Generalized Anxiety Disorder Scale (GAD-7) |  | At treatment start (0 weeks) | 
| 9-item Patient Health Questionnaire Depression Scale (PHQ-9) |  | At treatment termination (10 weeks) | 
| 7-item Patient Health Questionnaire Generalized Anxiety Disorder Scale (GAD-7) |  | At treatment termination (10 weeks) | 
| 9-item Patient Health Questionnaire Depression Scale (PHQ-9) |  | At treatment follow-up (7 months) | 
| 7-item Patient Health Questionnaire Generalized Anxiety Disorder Scale (GAD-7) |  | At treatment follow-up (7 months) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Emotional Processing Scale (EPS-25) |  | Two weeks before the treatment starts | 
| Emotional Processing Scale (EPS-25) |  | At treatment start (0 weeks) | 
| Emotional Processing Scale (EPS-25) |  | At treatment termination (10 weeks) | 
| Five Facets of Mindfulness Questionnaire (FFMQ) |  | Two weeks before the treatment starts | 
| Five Facets of Mindfulness Questionnaire (FFMQ) |  | At treatment start (0 weeks) | 
| Five Facets of Mindfulness Questionnaire (FFMQ) |  | At treatment termination (10 weeks) | 
| Emotional Processing Scale (EPS-25) |  | At treatment follow-up (7 months) | 
| Five Facets of Mindfulness Questionnaire (FFMQ) |  | At treatment follow-up (7 months) |