Saliva Profiles in Children With Congenital Heart Disease

Study Overview
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Brief Summary
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The purpose of this study was to evaluate whether there are relationships between the salivary oxidative stress status of children with CHD directly dental caries including gender, age, salivary flow rate, salivary pH, salivary buffering capacity and drug intake such as angiotensin-converting enzyme (ACE) inhibitors. If such relationships exist, they might be employed to patient caries -prevention treatment.

Detailed Description
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Using heart failure medications may cause low salivary pH and buffering capacity.As improved oral health is a priority for cardiac patients, it is necessary that they attend dental clinics for regular follow up. This cross sectional study was carried out with 42 CHD and 42 healthy children who applied to Istanbul University, Faculty of Dentistry, Department of Pedodontics. Gender, age, general health and medications, and caries scores (dfs/DMFS) were recorded. Unstimulated saliva was collected from the participants and were assessed for the salivary secretion rate, salivary buffering capacity, pH, protein levels, superoxide dismutase (SOD), ferric reducing antioxidant power (FRAP), the thiobarbituric acid reactive substances (TBARS), protein carbonyl, protein thiols, total sialic acid.

Official Title
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Saliva Profiles in Children With Congenital Heart Disease

Conditions
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Cardiac Disease, Dental Caries

Intervention / Treatment
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* Other: saliva


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 3-12 years Caridac problems Exclusion Criteria: other ages syndromes other systemic diseases

Ages Eligible for Study
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Minimum Age: 3 Years
Maximum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: cross sectional study was carried out with 42 CHD and 42 healthy children
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: congenital heart disease<br>42 patients | Other: saliva<br>* salivary secretion rate, salivary buffering capacity, pH, protein levels, superoxide dismutase (SOD), ferric reducing antioxidant power (FRAP), the thiobarbituric acid reactive substances (TBARS), protein carbonyl, protein thiols, total sialic acid.<br>|
| Other: helathy children<br>42 children | Other: saliva<br>* salivary secretion rate, salivary buffering capacity, pH, protein levels, superoxide dismutase (SOD), ferric reducing antioxidant power (FRAP), the thiobarbituric acid reactive substances (TBARS), protein carbonyl, protein thiols, total sialic acid.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| salivary secretion rate | salivary secretion rate | 2 hour | 
| salivary buffering capacity | salivary buffering capacity | 2 hour | 
| pH | pH | 2 hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| protein levels of saliva | protein levels | 2 hour | 
| superoxide dismutase (SOD) | superoxide dismutase (SOD) | 2 hour | 
| ferric reducing antioxidant power (FRAP) | ferric reducing antioxidant power (FRAP) | 2 hour | 
| the thiobarbituric acid reactive substances (TBARS) | the thiobarbituric acid reactive substances (TBARS) | 2 hour | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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saliva composition, antioxidant activity, caries risk factors, congenital cardiac disease