Exercise Capacity in COPD

Study Overview
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Brief Summary
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In this study, cardiopulmonary exercise will be assessed to characterize the relevance of severity of COPD and coexisting cardiovascular comorbidities for exercise capacity.

Detailed Description
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In patients with chronic obstructive pulmonary disease (COPD) the interpretation of dyspnoea also needs to consider coexisting cardiovascular disease. Cardiopulmonary exercise testing (CPET) is used to characterize pulmonary and cardiac function and limitations during exercise. The investigators hypothesise that cardiopulmonary exercise is reduced in COPD patients with coexisting cardiovascular disease as well as in more symptomatic patients and in patients with frequent exacerbations. For this purpose, 100 patients with with stable COPD are characterized by clinical characteristics, laboratory tests, lung function, electrocardiography, echocardiography and cardiopulmonary exercise testing.

Official Title
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Reduced Exercise Capacity in Patients With Chronic Obstructive Pulmonary Disease -Relevance of Cardiovascular Comorbidities

Conditions
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Chronic Obstructive Pulmonary Disease

Intervention / Treatment
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* Other: Measurement of lung function, electrocardiography, echocardiography and cardiopulmonary exercise testing


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with stable chronic obstructive pulmonary disease, exacerbated or stable 40-80 years sinus rhythm informed written consent Exclusion Criteria: Inability to give written consent acute myocardial infarction with ST-segment elevations in last 30 days severe acute or chronic renal dysfunction severe heart failure- atrial fibrillation severe valve disease severe hypoxemia long term oxygen therapy or non invasive ventilation

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients with stable COPD<br> | Other: Measurement of lung function, electrocardiography, echocardiography and cardiopulmonary exercise testing<br>* Measurement of lung function, electrocardiography, echocardiography and cardiopulmonary exercise testing<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of oxygen uptake during cardiopulmonary exercise testing (% predicted) |  | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| measurement of dyspnoea quantified by the COPD assessment test as well as the modified Medical Research Council Scale | For the assessment of the symptoms of the study group and its relation to exercise capacity dyspnoea is assessed by accepted questionnaires typically used for COPD patients at baseline | Baseline | 
| Measurement of FEV1 |  | Baseline | 
| Measurement the capillary pO2 in mmHg and capillary pCO2 at baseline | The blood gases pO2 and pCO2 are taken from the hyperaemic ear lobe to characterize the gas exchange during cardiopulmonary exercise which is a routine procedure | Baseline | 
| N-terminal pro brain natriuretic peptid (NTproBNP) in ng/L from peripheral venous blood at baseline | NTproBNP is analysed from peripheral venous blood to characterize potential heart failure and its relation to exercise capacity of the study subjects | Baseline | 
| Measurement of Maximum wattage during cardiopulmonary exercise testing |  | Baseline | 
| Measurement of Breathing reserve during cardiopulmonary exercise testing | BThe breathing reserve in % is assessed at the end of the cardiopulmonary exercise testing to characterize a ventilatory limitation of the exercise test. It is calculated as percent from the minute ventilation in relation to the maximum mandatory ventilation. The measurement is a routine measurement during cardiopulmonary exercise testing. | Baseline | 
| Measurement of Oxygen pulse during cardiopulmonary exercise testing |  | Baseline | 
| Presence of cardiovascular comorbidities | For the cardiopulmonary characterization clinical characteristics, lung function, blood gases, laboratory investigation, ECG and echocardiography were used in addition to cardiopulmonary exercise testing. | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cardiopulmonary exercise testing, cardiovascular comorbidities, cardiopulmonary interaction