Study on the Effect of Bile Reflux on Gastric Cancer and Its Precancerous Lesions: a Cross-sectional Study.

Study Overview
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Brief Summary
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To explore the effects of bile reflux on gastric cancer and its precancerous lesions, so as to better prevent the occurrence and development of gastric cancer.

Detailed Description
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This study was a multicenter cross-sectional study. Patients were consecutively enrolled and divided into gastric cancer group, gastric precancerous lesions group, and chronic gastritis group, according to histopathological results. The bile reflux detection rate and Helicobacter pylori infection status were recorded for each group.

Official Title
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Study on the Effect of Bile Reflux on Gastric Cancer and Its Precancerous Lesions: a Multiple Center, Cross-sectional Study.

Conditions
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Bile Reflux Gastritis, Gastric Cancer, Helicobacter Pylori Infection, Intestinal Metaplasia, Precancerous Lesions

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18 to 75 years old, gender is not limited; patients with upper abdominal pain, abdominal distension, belching, anorexia, early satiety, hiccup, acid reflux, upper abdomen burning sensation and other upper gastrointestinal symptoms; Voluntary acceptance of Hp testing; Voluntary acceptance of the endoscopy and pathological biopsy. Exclusion Criteria: had undergone upper gastrointestinal surgery; Previous diagnosis of esophageal cancer; Previous diagnosis of gastric cancer; Previous diagnosis of MALT lymphoma; pregnant and lactating women; Those with mental disorders; Refusal to sign the informed consent form.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| chronic gastritis<br>patients with chronic non-atrophic gastritis and chronic atrophic gastritis according to histopathological results | |
| precancerous lesion<br>patients with gastric intestinal metaplasia and intraepithelial neoplasia according to histopathological results | |
| gastric cancer<br>patients with gastric cancer according to histopathological results | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| corelation between the bile reflux and gastric mucosa diseases | we evaluate the corelation between the bile reflux and gastric mucosa diseases according to the histopathological results and the scales the patients finished | up to 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the risk factors of primary bile reflux gastritis | we evaluate the the risk factors of primary bile reflux gastritis according to the scales and endoscopical results | up to 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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gastric cancer; helicobacter pylori; precancerous lesion; bile reflux