Prognosis of Right Ventricular Dysfunction Assessed by Speckle Tracking in Postoperative Thoracic Surgery

Study Overview
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Brief Summary
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In postoperative thoracic surgery (lobe resection, pneumonectomy or wedge resection), cardiovascular complications are the most frequent (10 to 15%) with a significant morbi-mortality rate. Right ventricular (RV) dysfunction is a complication that can be multifactorial in post thoracic surgery. The RV longitudinal shortening fraction (RV-LSF) is a new 2D-STE parameters able to more accurately detect patients with RV dysfunction compared to conventional echocardiographic parameters. This project is a single-center, prospective, interventional study of patients hospitalized at the Amiens University Hospital for scheduled thoracic surgery. TTE is performed preoperatively, at day 2 and day 15 following the thoracic surgery. Echocardiographic parameters will be measured by an echocardiographic expert in offline with a dedicated software. MACE criteria will be collected at day 2, day 15 and day-30 following the thoracic surgery.

Official Title
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Prognosis of Right Ventricular Dysfunction Assessed by Speckle Tracking in Postoperative Thoracic Surgery: a Pilot Study

Conditions
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Right Ventricle, Thoracic Surgery

Intervention / Treatment
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* Other: transthoracic echocardiography (TTE)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patient (>18 years) Patient hospitalized at the Amiens University Hospital for scheduled thoracic surgery (lobectomy, pneumonectomy, wedge resection). Surgery by thoracotomy or video-assisted thoracic surgery Information of the patient and collection of his non-opposition Exclusion Criteria: Patient with poor echogenicity on TTE not allowing evaluation of 2D-STE or conventional parameters of the RV. Patient with a rapid supraventricular rhythm disorder (HR > 100) at the time of TTE Patient under mechanical ventilation Patient under extracorporeal membrane oxygenation Patients under guardianship or legal protection Patients whose clinical condition does not allow for their non-opposition Pregnant women

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: transthoracic echocardiography (TTE)|the included patients have a TTE preoperatively in order to evaluate the RV systolic function. TTE will also be done at day 2 and day-15 during the follow-up surgical consultation.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| occurrence of a major cardiovascular event (MACE) | MACE is a composite criteria. MACES criteria is defined as the occurrence of at least one of the following events: A cardiovascular death or a documented supraventricular tachycardia (atrial fibrillation and/or flutter) of duration > 30 seconds or, an acute myocardial infarction or, an hospitalization for a right ventricular failure or, an hospitalization for a left ventricular failure. | day 30 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Variation of RV systolic function from baseline in patients with MACE |  | at day 1 | 
| Variation of RV systolic function from baseline in patients without MACE |  | at day 1 | 
| Variation of RV systolic function from baseline in patients with MACE |  | at day 2 | 
| Variation of RV systolic function from baseline in patients without MACE |  | at day 2 | 
| Variation of RV systolic function from baseline in patients with MACE |  | at day 15 | 
| Variation of RV systolic function from baseline in patients without MACE |  | at day 15 | 
| Variation of RV systolic function from baseline in patients with MACE |  | within day 30 | 
| Variation of RV systolic function from baseline in patients without MACE |  | within day 30 | 
| Assessment of RV systolic function preoperatively |  | at day 30 | 
| occurrence of a postoperative complication |  | at day 30 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Right ventricle, speckle tracking, thoracic surgery