Comparison Between D&C and Hysteroscopy in Management of AUB in Perimenopausal Women

Study Overview
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Brief Summary
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The aim of this study is to compare dilatation and curettage with hysteroscopy in obtaining an accurate diagnosis of the etiology of abnormal uterine bleeding and outlining a mode of treatment-specific to the cause.

Detailed Description
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Perimenopausal women complaining of abnormal uterine bleeding will be selected for assessment through detailed history taking, general and abdominal examination, local gynecological examination, transvaginal sonography (TVS) scanning and routine blood investigations. Eligible participants in our study will be those who complain of menorrhagia, metrorrhagia, polymenorrhoea or polymenorrhagia without local gynecological cause with failure of medical treatment for at least 3 months. All women participating in the study will be randomly allocated into two groups; dilatation and curettage (D&C) group and hysteroscopy group. For women in the D&C group, cervical dilatation and fractional endometrial curettage will be done under total intravenous (IV) anesthesia in operation theater and the curetting will be sent for histopathological examination. For women in the hysteroscopy group, hysteroscopy will be done under total IV anesthesia in operation theater hysteroscopic-guided curettings will also be taken and sent for histopathological examination.

Official Title
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Comparison Between Dilatation and Curettage and Hysteroscopy in Management of Abnormal Uterine Bleeding in Perimenopausal Women

Conditions
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Uterine Bleeding

Intervention / Treatment
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* Procedure: D&C
* Procedure: Hysteroscopy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Perimenopausal women complaining of abnormal uterine bleeding (menorrhagia, metrorrhagia, polymenorrhoea or polymenorrhagia) without local gynecological cause. Failure of medical treatment for at least 3 months. Exclusion Criteria: Age < 45 or > 55 years. Blood disorders or coagulopathy. Diagnosed or suspected local gynecologic lesion (polyp, adenomyosis, myoma, malignancy or cervical pathology). Use intrauterine contraceptive device. Pregnancy related conditions.

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: D&C group<br>Women will undergo D&C | Procedure: D&C<br>* Cervical dilatation and fractional endometrial curettage will be done in operation theatre and the curetting will be sent for histopathological examination<br>* Other names: Dilatation and curettage;|
| Active Comparator: Hysteroscopy group<br>Women will undergo hysteroscopy | Procedure: Hysteroscopy<br>* Hysteroscopy will be done in operation theatre and hysteroscopic-guided curettings will also be taken and sent for histopathological examination<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of abnormal endometrial patterns | Number of patients diagnosed to have abnormal endometrial patterns after histopathological examination of the curretings per total number of patients underwent the procedure | One week after the procedure | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improvement rate | Number of patients improved after performing the procedure and recieving the treatment-specific to cause per total number of patients underwent the procedure | 3 months after the procedure | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Abnormal uterine bleeding, Dilatation and curettage, Hysteroscopy