Clinical Evaluation of Different Potassium Oxalate Concentrations in Dentin Hypersensitivity Treatment

Study Overview
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Brief Summary
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This study aims to evaluate the longevity and efficacy of two products potassium oxalate-basedin two concentrations, 10% and 5%, by triple randomized blind clinical trial (split-mouth) . The desensitization approach (single agent) and the long-term effectiveness (baseline, 1 week, 2 weeks, 3 weeks). Data will be collected, tabulated and submitted to statistical analysis.

Detailed Description
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Dentin hypersensitivity (DH) is characterized as a short, intense and sudden pain caused by thermal, chemical and evaporative stimuli. There are several types of desensitizing agents, used to aid in the control of this pathology, but they are not very effective and have short longevity. The agents based on potassium oxalate have been used by dental surgeons because they have mixed action, both neural and obliterating. Therefore, the aim of this study is through a triple blind randomized clinical trial (split-mouth), evaluate the longevity and efficacy of two products potassium oxalate-based in two concentrations, 10% and 5%. Thirty-two with DH at least 2 teeth and adequate oral hygiene will be randomly divided into two different groups according to the desensitization approach (10% and 5%) The dentin hypersensitivity level will be evaluated immediately after desensitization and after 1, 2 and 3. Data will be collected, tabulated and submitted to statistical analysis.

Official Title
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Clinical Evaluation of Different Potassium Oxalate Concentrations in Dentin: A Randomized Clinical Trial

Conditions
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Dentin Sensitivity, Hypersensitivity Dentin, Dentine Hypersensitivity, Dentin Hypersensitivity

Intervention / Treatment
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* Drug: Potassium Oxalate 5%
* Drug: Potassium Oxalate 10%


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy individuals Both genres, interested in the treatment of Dentin Hypersensitivity Patients with all teeth in their mouth Patients who have at least three teeth with Dentin hypersensitivity in different quadrants Good oral hygiene Exclusion Criteria: Caries or unsatisfactory restorations Presence of periodontal disease and or parafunctional habits Cracks or enamel fractures Extensive or unsatisfactory restorations Recent restorations involving the labial surface Pulpitis Dentures Orthodontics Smokers Pregnant women Gastroesophageal disease presence Uncontrolled systemic disease Severe bruxism Constant use of analgesic Allergic response to dental products

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Potassium Oxalate 5%<br>Prophylaxis of the teeth; an application every 48 hours; 4 sessions | Drug: Potassium Oxalate 5%<br>* Prophylaxis, apply uniformly on the teeth, friccion for 10 seconds, wait 10 minutes, remove the gel from the teeth with cotton and abundant water.<br>Drug: Potassium Oxalate 10%<br>* Prophylaxis, apply uniformly on the teeth, friccion for 10 seconds, wait 10 minutes, remove the gel from the teeth with cotton and abundant water.<br>|
| Active Comparator: Potassium Oxalate 10%<br>Prophylaxis of the teeth; an application every 48 hours; 4 sessions | Drug: Potassium Oxalate 5%<br>* Prophylaxis, apply uniformly on the teeth, friccion for 10 seconds, wait 10 minutes, remove the gel from the teeth with cotton and abundant water.<br>Drug: Potassium Oxalate 10%<br>* Prophylaxis, apply uniformly on the teeth, friccion for 10 seconds, wait 10 minutes, remove the gel from the teeth with cotton and abundant water.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Level of cervical dentin hypersensitivity by using visual analog scale | Evaluation of the reduction in dentin hypersensitivity levels by using visual analog scale with a 3 weeks follow up. | 3 weeks |