Copeptin Registry (proCORE) Biomarkers in Cardiology (BIC)-19

Study Overview
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Brief Summary
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Registry of an interventional Study-proved Strategy (BIC-8) using Copeptin and Troponin for the Early Rule-Out of Acute Myocardial Infarction (AMI) in Patients with Suspected Acute Coronary Syndrome (ACS) and a low-to intermediate risk profile.

Detailed Description
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Registry of an interventional Study-proved Strategy (BIC-8) using Copeptin and Troponin for the Early Rule-Out of Acute Myocardial Infarction (AMI) in Patients with Suspected Acute Coronary Syndrome (ACS) and a low-to intermediate risk profile. Primary objective: To monitor the safety of the early rule-out strategy using combined testing of copeptin and troponin at admission of patients with signs and symptoms suggestive of ACS and a low- to intermediate risk profile, who are discharged or moved to another hospital after testing copeptin and troponin negative (defined as copeptin below 10 pmol/l and cardiac troponin below 99th percentile URL). Secondary objectives: To monitor routine application of the early rule-out strategy, patient characteristics, risk profile of all patients tested for copeptin and troponin at admission, irrespective of their biomarker test result To monitor diagnoses, clinical course and outcome of all patients tested for copeptin and troponin at admission

Official Title
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Copeptin Registry (proCORE) Biomarkers in Cardiology (BIC)-19

Conditions
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Acute Myocardial Infarction

Intervention / Treatment
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* Procedure: Routine management observation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Admission to the Emergency Department or CPU with signs and symptoms consistent with acute coronary syndrome Low-to intermediate risk profile (GRACE-score below 140 and a low- to intermediate likelihood of ACS as judged by the treating physician) Patients eligible for the early rule-out strategy using combined copeptin and troponin testing at admission, irrespective of biomarker test results and disposition decision full-aged patient Exclusion Criteria: none

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Routine management observation|Early rule out of myocardial infarction with combined copetine and troponin testing at admission|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| All-cause mortality | One-month all-cause mortality in patients in whom acute myocardial infarction is ruled-out using the early rule-out strategy and who are therefore discharged from the ED | 30 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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copeptin, rule out marker, emergency department, cheast pain unit, emergency department, chest pain unit