An Epidemiological Study on Antimicrobial Treatment of Nosocomial Infections in Clinical Practice

Study Overview
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Brief Summary
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The present study is a retrospective cohort study on patients who suffered a nosocomial infection in major hospitals in Vietnam. Data relating to patient demography include age, gender; medical history; APACHE II score; background conditions, infection details and antimicrobial therapy; and all-caused mortality, time of hospitalization and intensive care. The investigators hypothesis is that antimicrobial treatment inappropriate is highly dependent on incidence of antibiotic resistant pathogens, nonfermentative Gram-negative bacilli and ESBL-producing enterobacteriaceae spp. Variables are demographic characteristics, background conditions, immunosuppressive therapy, antimicrobial susceptibility and inappropriate treatment is explored as possible predictors of mortality.

Official Title
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An Epidemiological Study on Antimicrobial Treatment of Nosocomial Infections in Clinical Practice

Conditions
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Nosocomial Infection

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient was diagnosed as nosocomial infection defined according to criteria established by the US CDC. The diagnosis criteria for ventilator-associated pneumonia are modified from those established by the American College of Chest Physicians. Patient received empiric antimicrobial therapy within 24 hour from onset of infection and had antimicrobial susceptibility. Exclusion Criteria: A patient was in part of a controlled clinical trial for the current infection episode. Patients with suspected infections by virus or fungus or tuberculosis will be excluded.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Appropriate antimicrobial treatment | |
| 2<br>Inappropriate antimicrobial treatment | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The number and percentage of subjects with nosocomial infection received appropriate antimicrobial treatment |  | 30 days as from onset of nosocomial infection | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The number and percentage of patients with nosocomial infections received de-escalation therapy |  | 30 days as from onset of nosocomial infection | 
| The number and percentage of hospital mortality, the number of days for hospitalization, intensive care among groups of patients who received appropriate or inappropriate antimicrobial treatments |  | 30 days as from onset of nosocomial infection | 
| The determinants for inappropriate antimicrobial treatment and mortality. |  | 30 days as from onset of nosocomial infection | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Non-interventional study, Vietnam, inappropriate treatment, nosocomial infection