Trends of Morbidity and Mortality Among Thai HIV-infected and HIV-uninfected Patients: a Five-year Prospective Cohort Study

Study Overview
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Brief Summary
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To describe the morbidity and clinical characteristics among HIV-infected patients and HIV-uninfected patients. To identify the risk factors for the complication or morbidity among HIV-infected patients and HIV-uninfected patients. To describe the mortality among HIV-infected patients and HIV-uninfected patients. To identify the risk factors for the cause of death among HIV-infected and HIV-uninfected patients.

Detailed Description
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The information obtained from this study would be very important in planning future holistic care of HIV-infected patients in our institutes as well as in national policy. Results from the study could be used to develop proper long-term management guidelines for people living with HIV (PLHIV) in Thailand targeted at preventable conditions such as metabolic diseases and certain cancers.

Official Title
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Trends of Morbidity and Mortality Among Thai HIV-infected and HIV-uninfected Patients: a Five-year Prospective Cohort Study

Conditions
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HIV Infection, Healthy

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: HIV-infected patients group HIV positive 30 years of age or older, both male and female Thai nationality Written research informed consent HIV-uninfected patients group HIV un-infected 30 years of age or older, both male and female Thai nationality Written research informed consent Exclusion Criteria: HIV-infected patients group Systolic BP ≥ 130 or Diastolic BP ≥ 85mm Hg or on the treatment Fasting blood sugar > 126 mg/dl or on the treatment Proteinuria Creatinine > 1.5 mg/dl Recent hospitalization Patient who are having mental disease HIV-uninfected patients group Systolic BP ≥ 130 or Diastolic BP ≥ 85mm Hg or on the treatment Fasting blood sugar > 126 mg/dl or on the treatment Proteinuria Creatinine > 1.5 mg/dl Recent hospitalization Patient who are having mental disease

Ages Eligible for Study
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Minimum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| HIV-infected patients group<br>HIV positive | |
| HIV-uninfected patients group<br>HIV negative | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| morbidity | development of other diseases | 60 months | 
| HIV related illness | development of opportunistic infection such as Non-Hodkin's lymphoma, Kaposi's sarcoma | 60 months | 
| Non HIV-related illness | development of Dyslipidemia, Hypertension, DM, CVD , Cancer, osteopenia, osteoporosis, Renal disease, liver disease | 60 months | 
| mortality | death | 60 months | 
| CVD | development of CVD | 60 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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morbidity, mortality, HIV-infected patients, prospective cohort study, highly active antiretroviral therapy (HAART), opportunistic infections, Non HIV-related illness, cardiovascular disease (CVD), HIV negative patients, Thai HIV-infected patients