Studying Genes, Environment, and Prostate Cancer Risk in Patients With or Without Prostate Cancer

Study Overview
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Brief Summary
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RATIONALE: Gathering information about genetic and environmental factors may help doctors learn more about a person's risk for developing prostate cancer. PURPOSE: This research project is studying genes, environment, and prostate cancer risk in patients with or without prostate cancer.

Detailed Description
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OBJECTIVES: To determine the association between variation in genes involved in ROS detoxification, oxidative stress response, and prostate cancer risk. To determine the association between fatty acid levels and prostate cancer risk. OUTLINE: Probands undergo blood and saliva sample collection for fatty acid, DNA, and polymorphism analyses. Archived blood and tissue samples from probands who previously participated in Dr. Shannon's Diet and Prostate Cancer Risk study are also analyzed. Medical records of probands are reviewed for demographics, history and course of disease, and clinical laboratory test results. All probands completed the Genetic Risk Easy Assessment Tool Family History of Cancer and Diet History and Environmental Risk Factor questionnaires at baseline. If a proband previously participated on our Diet and Prostate Cancer Risk study, he was asked to complete the Changes in Diet, Prescriptions, Supplementals and Herbal Remedies questionnaire in addition to the Genetic Risk Easy Assessment Tool Family History of Cancer questionnaire at baseline for this study. PROJECTED ACCRUAL: A total of 750 participants will be accrued for this study.

Official Title
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Genetic Susceptibility, Environment & Prostate Cancer Risk

Conditions
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Hereditary Prostate Cancer, Prostate Cancer

Intervention / Treatment
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* Genetic: DNA analysis
* Genetic: polymorphism analysis
* Other: laboratory biomarker analysis
* Other: medical chart review
* Other: questionnaire administration
* Procedure: evaluation of cancer risk factors
* Procedure: study of high risk factors


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Meets 1 of the following criteria: Prior diagnosis of prostate cancer or negative prostate biopsy AND previously participated in Dr. Shannon's Diet and Prostate Cancer Risk study and consented to future studies (proband) Referred to the Portland VA Medical Center urology clinic for a prostate biopsy (proband) Introduced to this study by a proband OR found to be related to a proband who is part of a homogenous high-risk subgroup after completion of the family history of cancer analysis PATIENT CHARACTERISTICS: See Disease Characteristics PRIOR CONCURRENT THERAPY: See Disease Characteristics

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 120 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Probands<br> | Genetic: DNA analysis<br>* saliva samples will be collected from men (probands) who join the study.<br>Genetic: polymorphism analysis<br>* we will genotype DNA samples (buccal) from all probands and conduct a traditional case-control analysis<br>Other: laboratory biomarker analysis<br>* 10ml blood specimen will be obtained and processed (on probands locally-consented and/or those who have an appointment at the VA in Portland, Oregon) to allow for analyses of erythrocyte fatty acids and future nutrient and DNA analyses<br>Other: medical chart review<br>* PSA results, prostate biopsy pathology reports and clinician notes related to the biopsy are reviewed for final data analysis<br>Other: questionnaire administration<br>* probands are asked to complete questionnaires on 1) family history of cancer, 2) diet history over the past year, 3) employment environment and risk factors and/or 4) changes to diet, medications since enrollment in originating case control study<br>Procedure: evaluation of cancer risk factors<br>* pathology reports will be reviewed for probands whose prostate biopsies reveal cancer; these factors will be evaluated for cancer risk factors<br>Procedure: study of high risk factors<br>* prostate biopsy pathology reports will be reviewed for high risk factors<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Association between variation in genes involved in reactive oxygen species detoxification, oxidative stress response, and prostate cancer risk | Using saliva samples, we conducted analysis on probands' oxidative stress pathway genes and whether these were associated with prostate cancer risk. | through study completion; 1 day | 
| Association between blood fatty acids and prostate cancer risk | Using blood samples, we conducted analysis on probands' fatty acid level and whether these were associated with prostate cancer risk. | through study completion; 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hereditary prostate cancer, prostate cancer