Effect of Daily Use Proton Pump Inhibitors for One Month on Kidney Function

Study Overview
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Brief Summary
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The aim of this study to: evaluate the association between prolonged use of PPI and adverse renal outcomes on patients with normal renal function and others with abnormal renal function

Detailed Description
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Proton pump inhibitors (PPIs) are one of the most widely used classes of drugs and are prescribed primarily for gastric acid-related diseases, eradication of Helicobacter pylori, and prevention of nonsteroidal anti-inflammatory drug (NSAID)-induced gastropathy,and gastroesophagial reflux diseases . Although PPIs have an excellent overall safety profile, some severe adverse effects, which include bone fracture, dementia, myocardial infarction, infections, micronutrient deficiencies, and kidney diseases,PPIs may trigger acute interstitial nephritis,a potentially sever adverse event commonly associated with acute kidney injury The increase in prescription and inadequate use of this class of medication calls for studies on the effects of prolonged PPI therapy on renal function.

Official Title
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the Effect of Daily Use of Proton Pump Inhibitors for One Month on Renal Function

Conditions
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Proton Pump Inhibitor Allergy

Intervention / Treatment
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* Drug: pantoprazole


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with peptic ulcer disease or gastroesophagial reflux with normal l renal function patients with peptic ulcer disease or gastroeosophagial reflux with abnormal renal function Exclusion Criteria: 1- cigarette smoker: Cigarette smoking status was defined categorically as current,former, or never smoker at baseline. 2-biabetic patients: diabetes mellitus is defined by a fasting blood glucose concentration >_ 126 mg/dl ,random glucose level of >200 mg/dl. 3-patients take corticosteroid 4-patients with hypersensitivity to these drugs

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: pantoprazole with normal kidney function<br>use pantoprazole for one month and after one month i will do for them kidney functions test | Drug: pantoprazole<br>* effect of this drug on renal function<br>* Other names: Protonix;|
| Experimental: pantoprazole with abnormal kidney function<br>use pantoprazole for one month and after one month i will do for them kidney functions test | Drug: pantoprazole<br>* effect of this drug on renal function<br>* Other names: Protonix;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| kidney function | eGFR=175xage(y/0)x^(-0.203)xplasma creatinine (mg/dl)x^(-1.154) | one month |