linjc16/ctgov huggingface dataset:
Resistance Exercise Training at Different Intensities

Study Overview
=================
Brief Summary
-----------------
The aim of the current study, therefore, is to determine the feasibility of recruitment and adherence to resistance exercise training interventions performed at low and high loads, to volitional muscular failure, in a trial population that includes both healthy and frail older people.

Official Title
-----------------
Resistance Exercise Training at Different Intensities in Healthy and Frail Older People: A Feasibility Study

Conditions
-----------------
Sarcopenia, Frailty, Aging

Intervention / Treatment
-----------------
* Behavioral: Low Load Resistance exercise
* Behavioral: High Load Resistance exercise


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Over age of 65 years Exclusion Criteria: Current participation in an exercise programme Exercise deemed unsafe by clinical team

Ages Eligible for Study
-----------------
Minimum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Low load<br>Training at 30-40% one-repetition maximum (1RM) | Behavioral: Low Load Resistance exercise<br>* leg extension, leg press, leg curl and calf press<br>|
| Experimental: High load<br>Training at 65-75% one-repetition maximum (1RM) | Behavioral: High Load Resistance exercise<br>* leg extension, leg press, leg curl and calf press<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle strength | Knee extensor maximal torque during an isometric MVC | Change from baseline to 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vastus lateralis muscle thickness | Measured via ultrasound | Change from baseline to 8 weeks | 
| Muscle strength | Knee flexor maximal torque during an isometric MVC | Change from baseline to 8 weeks | 
| One-repetition maximum | leg extension, leg curl, leg press and calf press | Change from baseline to 8 weeks | 
| Biomechanics during walking and stair climbing | Motion analysis | Change from baseline to 8 weeks | 
| Short performance physical battery test | SPPB - balance, walking pace and chair rise | Change from baseline to 8 weeks | 
| Quality of life measure | EQ-5D-5L questionnaire | Change from baseline to 8 weeks |
A Study Comparison of Clinical Outcome After Different Rate of Infusion in Caudal Epidural Steroid Injection

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine the effects of different rates of Caudal Epidural Steroid Injection (CESI) on clinical outcomes of the patients.

Official Title
-----------------
A Prospective Study Comparison of Clinical Outcome After Different Rate Infusion in Caudal Epidural Steroid Injection

Conditions
-----------------
Spinal Stenosis, Lumbosacral Spondylosis, Radiculopathy

Intervention / Treatment
-----------------
* Drug: Triamcinolone Acetonide and normal saline solution


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: lumbosacral spinal stenosis with radiculopathy no improvement after conservative treatment for 6 weeks Exclusion Criteria: previous CESI or spinal surgery skin infection at injection site uncontrolled diabetes mellitus abnormal coagulogram vertebral fracture previous history of allergy to steroid or anesthetic agent

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group 1: 40 ml/min<br>Triamcinolone acetonide (80 mg)/2 ml and normal saline solution 18 ml infusion in 0.5 min | Drug: Triamcinolone Acetonide and normal saline solution<br>* 80 mg/2 ml Triamcinolone Acetonide and 18 ml normal saline solution<br>|
| Experimental: Group 2: 20 ml/min<br>Triamcinolone acetonide (80 mg)/2 ml and normal saline solution 18 ml infusion in 1 min | Drug: Triamcinolone Acetonide and normal saline solution<br>* 80 mg/2 ml Triamcinolone Acetonide and 18 ml normal saline solution<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline Visual Analogue Scale at 2, 6, 12 weeks |  | 2, 6, 12 weeks | 
| Change from baseline Roland 5-point pain scale at 2, 6, 12 weeks |  | 2, 6, 12 weeks | 
| Change from baseline Standing tolerance test at 2, 6, 12 weeks |  | 2, 6, 12 weeks | 
| Change from baseline Walking tolerance test at 2, 6, 12 weeks |  | 2, 6, 12 weeks | 
| Change from baseline Patient satisfaction scale at 2, 6, 12 weeks |  | 2, 6, 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complication of Caudal Epidural Steroid Injection |  | 2, 6, 12 weeks |
MRI in Renal Tumors

Study Overview
=================
Brief Summary
-----------------
Diagnostic imaging for renal masses of unknown nature using conventional imaging modalities such as 3 phase contrast-enhanced computed tomography (CT) is not always conclusive. After (partial) nephrectomy, 10-20 % of the resected tumors show benign histology which could not be identified on diagnostic imaging. With improved imaging techniques available, leading to improvements in characterisation of renal tumors, the number of unnecessary resections may be reduced. The objective of this study is to assess the ability to discriminate oncocytoma from RCC based on the ADC distribution parameters with addition of, tumor volume, and patient demographic characteristics.

Official Title
-----------------
Advanced MRI in Renal Tumors.

Conditions
-----------------
Renal Cell Carcinoma

Intervention / Treatment
-----------------
* Device: Magnetic Resonance Imaging


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Radiologic diagnosis of renal tumor based on previous ultrasonography, CT or MRI examinations. Signed Institutional Review Board (IRB) approved informed consent form. Being at least 18 years of age. Histopathologically confirmed renal tumor diagnosis. Exclusion Criteria: Relative contra indications for MRI (metal device/foreign bodies, claustrophobia); Active renal or perirenal infection; Minor and/or incapacitated adult.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Renal tumor.<br>Patients >18 years of age with histopathologically confirmed renal tumor diagnosis. | Device: Magnetic Resonance Imaging<br>* One MRI examination, diagnostic scanning protocol as used for renal tumours with additional diffusion weighted sequences, but without contrast enhancement.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Discriminating malignant from benign renal lesions using Apparent Diffusion Coefficient (ADC, a metric obtained by diffusion weighted MRI) value distribution analysis. |  | 45 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Additional value of tumor volume and patient characteristics to discriminate malignant from benign renal lesions. |  | 45 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Magnetic Resonance Imaging, Diffusion Weighted MRI, Diffusion Tensor Imaging
Botswana Diarrheal Diseases Study

Study Overview
=================
Brief Summary
-----------------
The goals of this study are to: determine the diarrheal rates, morbidity, mortality, and pathogens present among breast-fed infants born to HIV-infected mothers. analysis by HIV status of infants, method of feeding, HIV viral loads / CD4 counts of infected mothers. comparison to rates among infants born to HIV uninfected mothers. link analysis of the functional quality of immunoglobulins in the breast milk of HIV-infected and uninfected mothers.

Official Title
-----------------
Botswana Diarrheal Diseases Study

Conditions
-----------------
HIV Infections

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subject is able to provide independent informed consent. Subject is able to complete a questionnaire as part of her enrollment visit and agrees to complete follow-up questionnaires monthly. Subject presents symptoms of acute diarrhea: at least 3 loose stools during 24 hours as reported by mother; persistent diarrhea: an episode of diarrhea lasting 14 days; recurrent diarrhea: a new episode of diarrhea after an interval of at least two diarrhea-free days. For HIV-infected subjects: Mother: HIV antibody is detected by dual HIV-1 ELISA and confirmed by western blot. Infant: HIV antigen is detected by PCR on 2 samples during the follow-up period, or on 1 sample followed by the death of the infant. Exclusion Criteria: Subject cannot provide legal independent informed consent.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Diarrheal specimens from infants born to HIV infected mothers<br>400 diarrheal specimens will suffice to determine the prevalence of specific pathogens in the region. Of these, 300 specimens will be collected from infants born to HIV infected mothers, and 100 specimens will be collected from infants born to HIV uninfected mothers. | |
| Breast milk from HIV infected and HIV uninfected women<br>Breast milk from HIV infected and HIV uninfected women who are breastfeeding is collected at 2 days, 2 weeks, 2 months, and 5 months post-partum. This breast milk will be compared for in vitro functional quality of immunoglobulins to selected diarrheal and respiratory pathogens. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| OCCURRENCE OF SUSPECTED PNEUMONIA OR BLOODSTREAM INFECTION OVER FIRST TWO YEARS OF LIFE |  | 24 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Prevention of Mother-Infant HIV Transmission
Optic Nerve Sheath Diameter in Prediction of Fluid Responsiveness

Study Overview
=================
Brief Summary
-----------------
The aim of the study to examine Optic Nerve Sheath Diameter measurement for prediction of fluid responsiveness in hemodynamically unstable patients

Official Title
-----------------
Prospective Study: Optic Nerve Sheath Diameter in Prediction of Fluid Responsiveness

Conditions
-----------------
Fluid Responsiveness, Optic Nerve Sheath Diameter, Shock

Intervention / Treatment
-----------------
* Device: Optic Nerve Sheath Diameter (ONSD) measurement by ultrasound


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients on mechanical ventilation 18 years or older patients developing hypotension (Mean arterial blood pressure) <65 mmHg Exclusion Criteria: Patients with Spontaneously breathing activity. Patients with a history of intracranial disease e.g. (stroke, TBI, causes of increased intracranial pressure). local cause in the eye as (Glaucoma, Single eye) Need for high PEEP. Known history of cardiac disease. Organ/s failure at admission

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Unstable patients<br>Patients on mechanical ventilation, 18 years or older and developing hypotension (Mean arterial blood pressure) <65 mmHg | Device: Optic Nerve Sheath Diameter (ONSD) measurement by ultrasound<br>* ONSD measurements will be performed in the supine patient. Ultrasound gel will be applied over the closed upper eyelid. The ultrasound probe will be placed on the temporal area of the eyelid. Then the probe will be angled in order to display the entry of the optic nerve into the globe. ONSD will be measured 3 mm behind the globe in the transverse plane perpendicular to the optic nerve. For each optic nerve three measurements will be made. The ONSD corresponds to the mean of the six values which will be obtained from each patient (three measurements for each eye).<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The cut-off value of optic nerve sheath diameter (ONSD) for prediction of fluid responsiveness |  | first day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between Stroke Volume Variation (by electrical cardiometry) and ONSD |  | first day |
Functional Neuroimaging of Postural Reconstruction

Study Overview
=================
Brief Summary
-----------------
To study in two cross-sections of healthy volunteers, with single photon emission computed tomography (SPECT), the possible changes generated in the mid-term by two rehabilitation techniques: the postural reconstruction and the muscular stretching. The changes in the cortical activation patterns will be estimated during a non-specific position of the ankle, held static. The influence of each technique will be estimated though the evidence of a change in the functional mapping of the areas activated during the defined motor task on healthy volunteers.

Detailed Description
-----------------
This is a monocentre, randomized study.

Official Title
-----------------
Functional Neuroimaging of Postural Reconstruction: Preliminary Study on a Dorsiflexion Motion of the Ankle and Comparison Between an Arm Following Postural Reconstruction Program and a Comparator Arm Following a Muscular Stretching Program

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Radiation: SPECT : ECD-Tc99m - Neurolite, Bristol-Myers Squibb Medical Imaging


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: male or female 18 to 35 years old Exclusion Criteria: pregnant, lactating

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Postural Reconstruction<br> | Radiation: SPECT : ECD-Tc99m - Neurolite, Bristol-Myers Squibb Medical Imaging<br> <br> |
| Active Comparator: muscular stretching<br> | Radiation: SPECT : ECD-Tc99m - Neurolite, Bristol-Myers Squibb Medical Imaging<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in the functional mapping of the areas activated during the defined motor task on healthy volunteers. |  | 8 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Volunteers, healthy subjects
Social and Emotional Brain Function in Cannabis Users

Study Overview
=================
Brief Summary
-----------------
The aim of this functional magnetic resonance imaging (fMRI) study is to find out whether and how social and emotional brain function are altered in dependent cannabis users relative to healthy non-using control subjects after a 28 supervised abstinence period. Previous research in cannabis users has predominantly focused on cognitive functions. Moreover, studies have implicated that observed deficits in cannabis users may regenerate after a prolonged abstinence period. Findings might provide important information with respect to relapse vulnerability.

Official Title
-----------------
Long-term Effects of Cannabis Use on Social and Emotional Brain Processes in Dependent Cannabis Users After a 28 Day Abstinence Period

Conditions
-----------------
Cannabis Dependence

Intervention / Treatment
-----------------
* Other: fMRI


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Cannabis dependence according to DSM 4 criteria 28 days of supervised abstinence Exclusion Criteria: other DSM 4 diagnosis neurological disorders

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cannabis Dependence<br>Cannabis dependent individuals according to DSM 4 criteria, aged 18-40 years | Other: fMRI<br> <br> |
| Healthy<br>Healthy controls, socio-demographically matched | Other: fMRI<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| fMRI neural activation patterns of social-emotional brain processes after 28 day abstinence | Activity patterns in core regions of the emotion processing & addiction-related brain networks (e.g. striatal regions, insular cortex, prefrontal cortex) will be assessed after 28-days of abstinence. Alterations will be determined by comparison with matched non-drug using controls | one timepoint = fMRI assessment after 28 day abstinence period | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ratings of subjective experience (pleasantness, rewarding value) will be assessed after 28 days of abstinence | Self-reported ratings of pleasantness & rewarding value during soft-pleasant touch. | one timepoint = during fMRI assessment after 28 day abstinence period | 
| Relapse interview assessed with Timeline-Followback Method | Association between fMRI neural correlates and drug use during follow up period as predictor of relapse | one timepoint = 24 months post-fMRI-session | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
addiction, cannabis, fMRI
Umbilical Cord Blood-derived Mesenchymal Stem Cells in Regeneration of Sweat Glands and Body Repair

Study Overview
=================
Brief Summary
-----------------
Patients with skin injury treated with Umbilical Cord Blood-derived Mesenchymal Stem Cells,such as deep burn damaged sweat glands,Effectiveness of Umbilical Cord Blood-derived Mesenchymal Stem Cells in Regeneration of Sweat Glands and Body Repair is determined.

Official Title
-----------------
Umbilical Cord Blood-derived Mesenchymal Stem Cells in Regeneration of Sweat Glands and Body Repair

Conditions
-----------------
Sweat Gland Diseases

Intervention / Treatment
-----------------
* Biological: UCB Mesenchymal Stem Cells treatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Burn area:10-20％TBSA Exclusion Criteria: Have influence on the speed of wound healing of patients with chronic diseases

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: UCB Mesenchymal Stem Cells<br>UCB Mesenchymal Stem Cells treatment of patients with skin injury | Biological: UCB Mesenchymal Stem Cells treatment<br>* reduce skin injury<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Frequency of Adverse Events | Frequency and severity of Adverse Events | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Active and inactive lesion count |  | 6 months |