Comparison of Autogenous Periosteal Pedicle Graft and Collagen Membrane in Management of Periodontal Intrabony Defects

Study Overview
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Brief Summary
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A clinical and radiographic evaluation of autogenous periosteal pedicle graft in comparison with collagen membrane for management of periodontal intrabony defects.

Detailed Description
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Twenty patients suffering from advanced chronic periodontitis were included in this randomized controlled clinical trial. Each subject contributed matched pairs of two- or three-walled intrabony defects. Each pair of periodontal defects were randomly assigned into the experimental group; periosteal pedicle graft guided tissue membrane or the positive control group; bioresorbable collagen guided tissue regeneration membrane. Clinical and radiographic parameters were recorded at baseline and at 6 months postoperatively.

Official Title
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Comparison of Autogenous Periosteal Pedicle Graft and Collagen Membrane in Management of Periodontal Intrabony Defects: A Randomized Controlled Clinical Trial.

Conditions
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Chronic Periodontitis

Intervention / Treatment
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* Procedure: Periosteal pedicle graft
* Biological: Bioresorbable collagen membrane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Severe chronic periodontitis patients with at least two sites with pocket depth ≥ 6 mm and clinical attachment level ≥ 5 mm, with radiographic evidence of bone loss 2- or 3-wall intrabony defect depth ranging from 3 to 6 mm as detected in periapical radiographs The facial surface of teeth adjacent to the interproximal defect should be free of extensive recession and marginal bone loss, with at least a 4 to 5 mm band of keratinized gingiva to allow for periosteal manipulation Exclusion Criteria: Pregnant women Subjects had <22 permanent teeth Having any given systemic disease Taking any type of medication and/or antibiotic therapy during the 3 months before the study Received periodontal treatment within the past 12 months Current or former smokers

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: periosteal pedicle graft<br>autogenous marginal periosteal pedicle graft harvested by partial thickness periodontal flap. | Procedure: Periosteal pedicle graft<br>* Autogenous pedicle graft harvested from the periosteum<br>|
| Active Comparator: Bioresorbable collagen membrane<br>Equine Achilles tendon collagen barrier membrane | Biological: Bioresorbable collagen membrane<br>* Biocollagen is a thin equine Achilles tendon collagen barrier membrane used for guided tissue regeneration<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical Attachment Level | Estimation of clinical attachment level in chronic periodontitis patients at baseline and 6 months after guided tissue regeneration | Baseline and 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pocket Depth | Estimation of pocket depth in chronic periodontitis patients at baseline and 6 months after guided tissue regeneration | Baseline and 6 months | 
| Bone Defect Area | linear measurements collected from a digital radiography program to estimate percentage of defect fill. | Baseline and 6 months |