Comparison Between spIgE and Skin Prick Test of Local and Imported Aeroallergens

Study Overview
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Brief Summary
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The prevalence of Allergic rhinitis(AR) and asthma was increased world wide. In 1998, ISAAC found that prevalence of AR and asthma inThailand was in moderately high group. Tests for immediated reaction SPT and spIgE, were used for evaluated sensitization of allergen in patient. They guided the investigators for proper management as well as patient education. Clinician will use the result for choose allergen in case that might need immunotherapy. SPT is safe and more economic for patient. Specific IgE has an advantage in patient who cannot withhold antihistamine prior SPT. In United state had a trial of result between SPT and spIgE for cockroach, cat, house dust mite and mold. It showed the correlation between two tests. In Thailand, the investigators haven't had data about it yet.

Detailed Description
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SPT and specific IgE for allergens is necessary for allergen avoidance and specific immunotherapy. To have local allergen extracts will help the patients to easier get the appropriate management

Official Title
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In-vivo Potency Evaluation of American Cockroach, Dog, Cat, Dust Mites and Mold Allergen Extracts Produced by Siriraj Hospital Comparing With Imported Extracts by Using Skin Prick Test.

Conditions
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Immediate Hypersensitivity

Intervention / Treatment
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* Procedure: Skin prick test
* Other: specific IgE measurement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient with controlled Asthma and/or AR (mild to moderate severity) who were diagnosed in Allergy clinic and ENT clinic, Siriraj hospital SPT positve one of American Cockroach, House dust mite, cat, dog and mold. Patient were consented to trial. Exclusion Criteria: Chronic disease such as heart disease, liver, renal and severe sepsis History of anaphylaxis Skin rash Pregnancy

Ages Eligible for Study
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Minimum Age: 10 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Skin prick test with aeroallergens<br>Mean wheal diameters of SPT with commercial and local American coakroach, house dust mite, cat, dog and mold | Procedure: Skin prick test<br>* skin prick test to American cockroach, dog, cat, dust mite and mold allergen extracts are performed<br>Other: specific IgE measurement<br>* measure specific IgE of American cockroach, dog, cat, dust mite and mold<br>|
| Experimental: specific IgE measurement<br>specific IgE levels of commercial and local American coakroach, house dust mite, cat, dog and mold | Procedure: Skin prick test<br>* skin prick test to American cockroach, dog, cat, dust mite and mold allergen extracts are performed<br>Other: specific IgE measurement<br>* measure specific IgE of American cockroach, dog, cat, dust mite and mold<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mean wheal diameter of SPT of local and imported allergen extracts and specific IgE levels | measure and compare SPT result of local and imported allergen extracts | 18 months |