linjc16/ctgov huggingface dataset:
Wounds Protocol at Family Health Strategy Units in a Rio Grande do Sul Countryside Town

Study Overview
=================
Brief Summary
-----------------
Evaluate the process for implementing a wound protocol for lesion control and cost-effectiveness in the context of the Family Health Strategy in the city of Santa Cruz do Sul, Brazil.

Official Title
-----------------
Implementing and Assessing an Wounds Protocol at Family Health Strategy Units in a Rio Grande do Sul Countryside Town

Conditions
-----------------
Chronic Vascular Wounds in Adults

Intervention / Treatment
-----------------
* Combination Product: Wounds Protocol


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Presenting vascular (venous, arterial or mixed) ulcers for over 1 year; Be available to have wounds dressed at the healthcare unit; Be a patient registered with the Family Health Strategy teams. Exclusion Criteria: Have some condition rendering the patient unable to go to the unit, such as being bedridden or having had a lower limb amputated; Having decompensated diabetes mellitus; Having move away from the Family Health Strategy unit's coverage area.

Ages Eligible for Study
-----------------
Minimum Age: 60 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: INTERVENTION GROUP<br>This group comprises 6 healthcare units equipped with a Family Health Strategy, where patients are seen by coordinating nurses who have been trained to use wound dressing supplies and also on the use of the protocol. | Combination Product: Wounds Protocol<br>* Nurses who have been trained to use wound dressing supplies and also on the use of the protocol.<br>|
| Active Comparator: CONTROL GROUP<br>This group comprising 5 healthcare units equipped with a Family Health Strategy. Patients were seen by coordinating nurses who used techniques and supplies with which they were already familiar. They had no protocol in place. | Combination Product: Wounds Protocol<br>* Nurses who have been trained to use wound dressing supplies and also on the use of the protocol.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lesion remission by measuring the surface area of the wound | Remission of the wound, and other clinical variables such as odor, pain, infection and presence of exudate. | one month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
nursing care, skin lesions, wound healing, varicose ulcers
Long-term Study of Ciclosporin for Atopic Dermatitis

Study Overview
=================
Brief Summary
-----------------
In patients with severe adult atopic dermatitis, the safety and efficacy of OL27-400MEPC will be assessed by repeating oral administration at a dose of 3 mg/kg/day (2-5 mg/kg/day) in 2 divided doses daily for 8-12 weeks and recovery until 52 weeks after starting treatment

Official Title
-----------------
Long-term Study of Ciclosporin for Atopic Dermatitis

Conditions
-----------------
Severe Atopic Dermatitis

Intervention / Treatment
-----------------
* Drug: ciclosporin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Appropriate the definition/diagnosis criteria of atopic dermatitis of the Japanese Dermatological Association Patients with severest atopic dermatitis [according to the Guidelines for Treatment of Atopic Dermatitis 2002, the severity of atopic dermatitis will be classified as severest when an eruption associated with severe inflammation (a lesion associated with erythema, papule, erosion, infiltration, lichenification, etc.) is noted on at least 30% of body surface on the day of subject enrollment]. Exclusion Criteria: Patients who received oral preparations, injections, inhaled preparations and suppositories of steroids or immunosuppressants other than tacrolimus hydrate ointments within 14 days of subject enrollment Patients who might receive the oral/injection drugs which are known to enhance nephrotoxicity, increase serum potassium levels, HMG-CoA reductase inhibitors or theophylline during the treatment period. Patients who received or are receiving an ultraviolet therapy (PUVA therapy, etc.) Patients with hypertension, active infectional disease, gout etc. Other protocol-defined exclusion criteria may apply.

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 64 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: ciclosporin|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Atopic Dermatitis, Ciclosporin,
Functional Magnetic Resonance Imaging in Infants

Study Overview
=================
Brief Summary
-----------------
The study proposes to evaluate cognitive development in infants four months or younger by functional MRI and event related potential recording. fMRI imaging will be obtained following an auditory stimulus inside the 4 tesla magnet at the Center for Magnetic Resonance Research and will be correlated with ERP response to the same stimulus.

Official Title
-----------------
Functional Magnetic Resonance Imaging (fMRI) in Infants

Conditions
-----------------
Healthy, Infant, Newborn, Diseases

Participation Criteria
=================
Eligibility Criteria
-----------------
Male or female infants less than 4 months old

Ages Eligible for Study
-----------------
Minimum Age: 1 Day
Maximum Age: 4 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cognition, Infant Development, MRI, Functional
QUANTACT : Impact of Pangenomic QUANTitative Alterations in Cancer Therapy

Study Overview
=================
Brief Summary
-----------------
Precision medicine and targeted therapies have played a crucial role over the past ten years in the personalized care of cancer patients. In this retrospective and observational study, we focused on patients for which no standard or curative treatment was available and for which the management was discussed in a Molecular Tumor Board (MTB). The role of the MTB is to decide the most appropriate therapeutic options for patients according to the potential identification of molecular targets. Among the analyses carried out, we focused on a quantitative genome-wide analysis: the CGH/SNP-array (Comparative Genomic Hybridization / Single Nucleotide Polymorphism on array). The objective was to evaluate the impact of CGH/SNP-array analyses in the identification of targeted molecular alterations. 

Official Title
-----------------
QUANTACT : Impact of Pangenomic QUANTitative Alterations in Cancer Therapy

Conditions
-----------------
Solid Tumor

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Histologically or cytologically confirmed solid tumor malignancy that is advanced or metastatic ; no standard or curative treatment available; non-opposition of the patient collected. Exclusion Criteria: multiple cancer patient; ECOG Scale of Performance Status (PS) ≥2
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of targeted molecular alterations | Number of targeted molecular alterations | at day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients eligible for targeted therapy (clinical trials or off-label drug) | Number of patients eligible for targeted therapy (clinical trials or off-label drug) | at day 0 |
MYocardial DOmmages Related to COVID-19

Study Overview
=================
Brief Summary
-----------------
Myocardial injury, as assessed by elevation of cardiac troponins (Tnc), is frequent among patients with COVID-19. Although rare autopsy cases reported COVID-19 related myocardial inflammation, the origin of Tnc elevation is unknown to date. Several cardiac causes, such as myocarditis, non-ischemic myocardial injury (NIMI), or myocardial infarction (MI) may lead to Tnc kinetic. Our work will test the hypothesis that during SARS-Cov2 infection, the elevation of cardiac biomarkers could be linked to the occurrence of myocarditis.

Official Title
-----------------
MYocardial DOmmages Related to COVID-19

Conditions
-----------------
Covid19, Non Ischemic Myocardial Injury, Myocardial Infarction, Myocarditis, Troponin Elevation

Intervention / Treatment
-----------------
* Biological: Biological data
* Other: Clinical data


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: COVID-19 positive patient hospitalized < 72 h after symptoms onset with troponin assessement. Exclusion Criteria: patients hospitalized > 72h after symptom onset

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| A<br>COVID positive and Troponin positive | Biological: Biological data<br>* Biological data<br>Other: Clinical data<br>* Clinical data<br>|
| B<br>COVID positive and Troponin negative | Biological: Biological data<br>* Biological data<br>Other: Clinical data<br>* Clinical data<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| characterize the myocardial damage associated with CoV-2 SARS infection | Myocardtitis diagnosis in patients COVID+ and troponin+ | Through study completion, an average of 2 years |
Evaluation of New Semen Collection & Transportation Kit

Study Overview
=================
Brief Summary
-----------------
Examine the effect of overnight transport conditions on sperm parameters on semen samples collected and mailed to Cleveland Clinic Andrology center.

Official Title
-----------------
Evaluation of New Semen Collection & Transportation Kit in Maintaining the Quality of Semen Subjected to Overnight Shipping

Conditions
-----------------
Sperm Parameters in Fertile and Infertile Men

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Normal healthy men with normozoospermic semen parameters Infertile men referred by the infertility specialist (urologist) Exclusion Criteria: Controls with abnormal semen parameters Infertile men from other referrals (Gynecologists) Severe oligozoospermic (<1 x 106 sperm/mL) infertile men
Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sperm concentration | Change in sperm concentration from 0 to 24 hours in millions per mL | 24 hours | 
| Sperm motility | Change in sperm motility from 0 to 24 hours in % | 24 hours | 
| Sperm forward motility | Change in sperm forward motility from 0 to 24 hours in % | 24 hours | 
| Sperm morphology | Change in sperm morphology from 0 to 24 hours using Kruger criteria | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sperm concentration | Change in sperm concentration from 0 to 36 hours in millions per mL | 36 hours | 
| Sperm motility | Change in sperm motility from 0 to 36 hours in % | 36 hours | 
| Sperm forward motility | Change in sperm forward motility from 0 to 36 hours in % | 36 hours | 
| Sperm morphology | Change in sperm morphology from 0 to 36 hours using Kruger criteria | 36 hours |
Leptin Levels in Papillary Thyroid Cancer

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate Leptin levels in females, in the setting of papillary thyroid cancer, benign thyroid nodules, and in normal females without thyroid disease.

Detailed Description
-----------------
There will be three groups in this study, but 2 of the groups are part of another study so will only recruit normal controls.

Official Title
-----------------
Assessment of Serum Leptin Levels in Females With Papillary Thyroid Carcinoma, Benign Thyroid Nodules, and Normal Controls

Conditions
-----------------
Thyroid Cancer, Papillary, Leptin Levels

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Female Age>/- 19 Not currently pregnant or lactating Normal thyroid gland by history Exclusion Criteria: Male Gender Pregnancy Lactation Age below 19 Abnormal thyroid gland by history Abnormal thyroid gland by structure using ultrasound Abnormal thyroid gland by function using TSH, Free T4

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| evaluating Leptin level Evaluating Serum Leptin Levels Between 3 Groups. One Group with Papillary Thyroid Carcinoma. One Group With Benign Nodules. One Group with Normal Thyroid. | Assessing serum leptin levels in females with treated papillary thyroid carcinoma and compared to females with proven benign thyroid nodules and females with normal thyroid glands. All groups were matched by gender, age, and BMI to limit confounders. | During Study |
Ultrasonographic Detection of Musculocutaneous Nerve in Children

Study Overview
=================
Brief Summary
-----------------
Localizing the musculocutaneous nerve for neural blockade is crucial to achieve complete anesthesia of the forearm. However, in pediatric anesthesiology, the musculocutaneous nerve is unable to be blocked in up to 40-50% of cases when only neurostimulation is used, while there is limited information regarding ultrasound imaging of the musculocutaneous nerve in children. The aim of this prospective imaging study is to investigate whether musculocutaneous nerve is visualized in childhood with the use of ultrasound imaging or not. A secondary aim of this study is to assess the percentage of its visualization according to the age. Parental written informed consent is obtained from all participants. The children are divided into three groups according to their age: Group 1, with infants aged less than 12 months; Group 2, with toddlers and preschoolers; and Group 3, with school-aged children (6.5-12 years). Children are placed in the supine position with the involved arm abducted at 90° and the elbow flexed at 90°. The linear probe of a portable ultrasound machine is placed at the axillary region, perpendicularly to the axillary artery. The musculocutaneous nerve is searched near the axillary artery (proximally) and its course is followed distally (into the coracobrachialis muscle). Its sonographic detection is recorded in these two sites, both proximally and distally.

Official Title
-----------------
Ultrasound Imaging of Musculocutaneous Nerve in Infants, Preschoolers and Children

Conditions
-----------------
Sonographic Detection of Musculocutaneous Nerve

Intervention / Treatment
-----------------
* Other: Ultrasound examination of the axilla


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: children 0-12 years old parental written informed consent Exclusion Criteria: parental refusal children refusal previous operations to the axilla anatomical malformations of the axilla spasticity morbid obesity.

Ages Eligible for Study
-----------------
Maximum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Ultrasound examination<br>Ultrasound examination of the axillary region in children | Other: Ultrasound examination of the axilla<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assession of the ultrasonographic visualization rate of musculocutaneous nerve in children |  | Data is assessed during sonographic examination of the axillary region | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
children, infants, musculocutaneous nerve, ultrasonography
Collection of Cerebrospinal Fluid in Healthy Children

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to obtain cerebrospinal fluid from healthy children already undergoing a lumbar puncture procedure at New York Presbyterian Hospital, to act as healthy controls when compared to children with late infantile neuronal ceroid lipofuscinosis (LINCL), a fatal neurodegenerative disease.

Detailed Description
-----------------
obtain cerebrospinal fluid from healthy children already undergoing a lumbar puncture procedure at New York Presbyterian Hospital, to act as healthy controls when compared to children with late infantile neuronal ceroid lipofuscinosis (LINCL), a fatal neurodegenerative disease.

Official Title
-----------------
Collection of Cerebrospinal Fluid in Healthy Children

Conditions
-----------------
Late Infantile Neuronal Ceroid Lipofuscinosis, Batten Disease

Intervention / Treatment
-----------------
* Other: Group 1


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Males and females, ages 2 yrs to 8 yrs Children already undergoing a lumbar puncture procedure for clinical or diagnostic purposes Exclusion Criteria: Presence of any significant neurological diseases, as judged by the co-investigators Presence of any significant medical conditions including cancer

Ages Eligible for Study
-----------------
Minimum Age: 2 Years
Maximum Age: 8 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1<br>Study cohort is comprised of healthy children, ages 2yrs - 8yrs, who are already undergoing a lumbar puncture procedure at New York Presbyterian Hospital for clinical or diagnostic purposes. | Other: Group 1<br>* Collecting a small amount of cerebrospinal fluid (5 mL) from healthy children, ages 2 yrs - 8 yrs, who are already undergoing a lumbar puncture procedure at New York Presbyterian Hospital for clinical or diagnostic purposes.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cerebrospinal fluid (CSF) | The primary study endpoint is the metabolic profiling of 32 samples of cerebrospinal fluid from healthy subjects, in comparison to 32 samples of CSF from children with LINCL, to determine whether there are biomarkers found in the cerebrospinal fluid that are associated with LINCL. | 1 time point (once) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Spinal tap, Late infantile neuronal ceroid lipofuscinosis, Batten disease, Cerebrospinal fluid, Lumbar puncture
Dietary Intake and Vitamin D Level in Adult Women

Study Overview
=================
Brief Summary
-----------------
Vitamin D deficiency is most diagnosed among women living in the Kingdom of Saudi Arabia. Many factors have been attributed to the incidence of vitamin D deficiency. Saudi women are thought to be at greater risk for vitamin D deficiency because of their darker skin type and the likelihood of reduced ultraviolet exposure . The present study entitled, Dietary Intake and Vitamin D Level in adult Women, was formulated as there is paucity of data on the etiologic importance of dietary intake in Vitamin D level on blood on women. The major objective of the proposed study is to assess the effect of dietary intake of nutrients and level of vitamin D in women .

Detailed Description
-----------------
For this study, the investigators enrolled 168 women 35-55 years old to evaluate Vitamin D status and to determined whether status was correlated with Vitamin D deficiency. All women completed a self-administered questionnaire about personal socio-demographic characteristics; They all had anthropometric measurements of body mass index and waist circumference. A 24-hour dietary recall was administered to all women. The proximate analysis of 25 types of food was conducted according to the American Association of Organic Chemists (AOAC) methods. The following parameters were measured: serum calcium. Vitamin D, levels of parathyroid hormone.

Official Title
-----------------
Study is to Assess the Effect of Dietary Intake of Nutrients and Level of Vitamin D in Women

Conditions
-----------------
Deficiency of Vitamin D3

Intervention / Treatment
-----------------
* Other: Vitamin D status


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Women 35- 55 years old, Women who spoke Arabic language fluently, and Women who were willing to fill a 24-hour questionnaire and provide a serum sample for measurements. Exclusion Criteria: Women < 35 years old or > 55 years old.

Ages Eligible for Study
-----------------
Minimum Age: 35 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Vitamin D status<br>Subjects are recruited to asses Vitamin D status with no interventions | Other: Vitamin D status<br>* There is no intervention in this study<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vitamin D serum levels |  | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Calcium serum levels |  | 1 year | 
| Vitamin D and Calcium Intake |  | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Vitamin D, Calcium, Phytic Acid, body weight