Creatine Supplementation and Cognitive and Physical Tests

Study Overview
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Brief Summary
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To assess whether brain creatine availability has an effect on cognition. To do so we will seek to increase brain creatine concentration via a creatine supplementation protocol.

Official Title
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The Effect of Creatine Supplementation on Cognitive and Physical Tests

Conditions
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Healthy, Creatine Supplementation

Intervention / Treatment
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* Dietary Supplement: Creatine
* Dietary Supplement: Calcium lactate


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy (No neurological illness including cardiovascular, renal, and endocrine disorder) Male/female No medication / supplements Non-smoker Low to moderately active Between 18 and 35 years old Exclusion Criteria: Injuries Illness Use of medication Use of creatine in the last 3 months History of head trauma or seizure Vegetarian diet [24] Not being able to follow up the restrictions and prohibitions for the subjects (see Restrictions and prohibitions for the subjects)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Creatine supplementation<br>7-day creatine supplementation | Dietary Supplement: Creatine<br>* Participants will have to supplement themselves with creatine for 7 days (20g/day).<br>|
| Placebo Comparator: Placebo supplementation<br>7-day calcium lactate supplementation | Dietary Supplement: Calcium lactate<br>* Participants will have to supplement themselves with calcium lactate for 7 days (elemental calcium: 0.780g/day).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognitive performance - change in accuracy (%) during a 90-min cognitive task (i.e. Stroop task) | Accuracy (in %) will be assessed during a cognitive task, this cognitive task will be completed after both 7-day supplementation protocols (i.e. placebo and creatine) | During both lab visits (i.e. after both 7-day supplementation protocols); Accuracy (%) will be assessed during both lab visits with a 90-min cognitive task; Accuracy during the 90-min task will be reported as mean accuracy during 8 blocks of 11min15sec | 
| Cognitive performance - change in reaction time (milliseconds) during a 90-min cognitive task (i.e. Stroop task) | Reaction time (in milliseconds) will be assessed during a cognitive task, this cognitive task will be completed after both 7-day supplementation protocols (i.e. placebo and creatine) | During both lab visits (i.e. after both 7-day supplementation protocols); Reaction time (RT) will be assessed during both lab visits with a 90-min cognitive task; RT during the 90-min task will be reported as mean RT during 8 blocks of 11min15sec | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physical performance - reaction time (milliseconds) during a 7-min visuomotor reaction time task | Reaction time (in milliseconds) will be assessed during a visuomotor reaction time task, this physical task will be completed after both 7-day supplementation protocols (i.e. placebo and creatine) | During both lab visits (i.e. after both 7-day supplementation protocols); visuomotor reaction time will be assessed during both lab visits with a 7-min visuomotor reaction time task. |