linjc16/ctgov huggingface dataset:
To Determine if Sleep Deprivation Results in Increased Esophageal Acid Exposure

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine if sleep deprivation results in increased esophageal acid exposure in healthy controls and gastroesophageal reflux disease (GERD) patients.

Detailed Description
-----------------
To determine if increased esophageal acid exposure is mediated by altering appetite regulation. To assess if there is any relationship between sleep deprivation and the serum level of TNF-alfa (a protein that can be elevated in inflammation).

Official Title
-----------------
To Determine if Sleep Deprivation Results in Increased Esophageal Acid Exposure, and if This Effect is Mediated in Gastroesophageal Reflux Disease (GERD)Patients by Altering Appetite Regulation

Conditions
-----------------
Gastroesophageal Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male/Female - 18-80 2 or more episodes of heartburn a week for last 3 months Exclusion Criteria: Previous upper GI surgery Underlying co-morbidity Narcotic medications Psychotropic's and Benzodiazapines medications Hx of psychological abnormalities Hx of ETOH in previous 6 mos. Diabetes Mellitus Neuropathy Seizures Sleep Apnea Co-morbidity that interfere w/sleep Women who are pregnant, or childbearing yrs, not on BC

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No treatment<br>Subjects w/ condition and subjects w/o condition of GERD (gastroesophageal reflux disease) | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
GERD, SLEEP DEPRIVATION, APPETITE REGULATION, GHRELIN, LEPTIN
MRI Findings of Epiphyseal Growth Plate in Healthy Children

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to determine if by using MRI changes can be identified changes early on in the knees of young children that may be at risk for developing osteochondritis dissecans. If MRI can identify changes then better council can be offered about the risks of future activity and treatment options.

Detailed Description
-----------------
Each subject will be asked to undergo an MRI at enrollment, six,12, and 18 months. Subjects will be monitored for evidence of osteochondritis dissecans in order to determine if we can identify it and then create a treatment program to allow these children to avoid developing definitive disease

Official Title
-----------------
MRI Findings of Epiphyseal Growth Plate in Healthy Children

Conditions
-----------------
OCD - Osteochondritis Dissecans

Intervention / Treatment
-----------------
* Device: MRI


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 6-10-year-old children with a sibling with known OCD and 6-10-year-old children with a known OCD in the contralateral knee Exclusion Criteria: Unable to undergo an MRI

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 10 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| MRI<br>Subjects with healthy knees | Device: MRI<br>* No intervention - observational trial using MRI<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| OCD | The Development of Osteochondritis Dissecans is the outcome of interest | 18 months |
Three New Methods for Diagnosing Pancreas Cancer

Study Overview
=================
Brief Summary
-----------------
The purpose of this project is to evaluate and compare three new methods for diagnosis, staging, operability evaluation and treatment control of pancreas cancer. The investigators use contrast-enhanced ultrasound combined with the gastrointestinal hormones Secretin and Cholecystokinin, which triggers the enzyme production of pancreas. The hormones induce an increased metabolism and thus an increased blood flow through healthy pancreas tissue, however, not in tumor tissue. The investigators hope to be able to use this effect diagnostically. The patients included will also have a 64-slice-CT in order to evaluate, if an increased diagnostic safety can be reached compared to an older CT scanning method. All patients will also be examined for the tumor marker CA 19-9. Further, the investigators will examine if contrast-enhanced ultrasound can contribute with information in treatment control after either surgery or medical treatment.

Official Title
-----------------
Ultrasound With Contrast Agent, 64-Slice-CT and Tumormarkers for Diagnosing, Evaluation of Operability and Treatment Control of Pancreas Cancer

Conditions
-----------------
Pancreas Cancer

Intervention / Treatment
-----------------
* Procedure: Ultrasound and contrast agent


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: suspicion of cancer of the pancreas
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Ultrasound and contrast agent|contrast-enhanced ultrasound combined with the gastrointestinal hormones Secretin and Cholecystokinin, which triggers the enzyme production of pancreas|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
InterStim Prospective Database

Study Overview
=================
Brief Summary
-----------------
The study is to collect information from patient charts and patient questionnaires to evaluate the effects of nerve stimulation therapy on urinary dysfunction.

Detailed Description
-----------------
Men and women with urinary incontinence (leakage of urine), frequency, and bladder pain experience embarrassment, inconvenience, and a significant negative impact on their quality of life. Although traditional treatments such as medications, diet modification, and bladder training provide relief for some people, others do not experience improvement with these treatments. Recently, mechanical devices much like a heart pacemaker have been developed to stimulate the nerves (sacral and pudendal) responsible for controlling bladder function. During a two stage operation, a permanent electrical wire is implanted in the lower back and connected to a mechanical box (stimulator) implanted under the patients skin in the hip area. Participants will be asked to complete a set of questionnaires (Intake Form, Urinary Incontinence Treatment Network (UITN) Sexual Activity Questionnaire, Interstitial Cystitis Symptom Index and Problem Index, voiding diary) within 60 days prior to the procedure. Preoperative clinical information such as primary diagnosis, history of failed therapies, and medical history will be collected from the physician office record, and operative information will be collected from the inpatient hospital record. After the two stage operation (3, 6, and 12 months, then yearly thereafter as long as the device is in place) participants will be sent questionnaires. Upon completion and return to the study site

Official Title
-----------------
InterStim Prospective Database for Outcomes Research

Conditions
-----------------
Urinary Retention, Urinary Incontinence, Pelvic Pain

Intervention / Treatment
-----------------
* Device: Interstim Neuromodulation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients at least 18 years of age scheduled for sacral nerve stimulator implantation at William Beaumont Hospital, Royal Oak, Michigan who give informed consent to participate in the project. Exclusion Criteria: None

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Interstim Neuromodulation<br>Subjects undergoing implantation of an Interstim device for neuromodulation. | Device: Interstim Neuromodulation<br>* Two stage procedure to implant an interstim device for neuromodulation.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Urinary Retention, Urinary Incontinence, Pelvic Pain
Transrectal Photoacoustic Imaging of the Prostate

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to image human prostate tissue using a new transrectal photoacoustic imaging probe and correlate this with ultrasound and MRI imaging performed once the specimen has been surgically removed. We hope to see what we can visualize with our device as this has never been done before. Eventually, we hope to use a similar device to image the prostate in men being seen by their doctor for prostate cancer.

Official Title
-----------------
Transrectal Photoacoustic Imaging of the Prostate

Conditions
-----------------
Prostate Cancer

Intervention / Treatment
-----------------
* Device: Photoacoustic Imaging System


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosed with clinically-localized prostate cancer Participant desires prostatectomy Male Patient receiving treatment at Palo Alto Veterans Administration (VA) Hospital Age 18 to 80 years old English-speaking Exclusion Criteria: Cannot tolerate a surgical prostatectomy due to medical comorbidities Cannot give informed consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Prostate Cancer Group<br> | Device: Photoacoustic Imaging System<br>* manufactured by Endra<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of images obtained | Pilot study to better understand the quality of both ultrasound and photo acoustic images that can be obtained using a transrectal instrument. To understand acquisition parameters that help optimize the image quality. | 18 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Prostate Cancer, Transrectal Imaging
Examination and Treatment of Elderly After a Fall

Study Overview
=================
Brief Summary
-----------------
Falls and injurious falls are common among elderly people. The aim of the study is to test a model of multifactorial fall intervention in a Danish population of elderly sustaining a fall. Focus is on prevention of further falls, patients views on fall prevention and a cost-effectiveness analysis.

Official Title
-----------------
Examination and Treatment of Elderly After a Fall- an Analysis in a Medical Technology Evaluation Perspective

Conditions
-----------------
Accidental Falls

Intervention / Treatment
-----------------
* Other: multifactorial intervention
* Other: Usual care


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 65 years old or older Having been treated in emergency department or submitted to hospital after a fall Living in the Glostrup area. Exclusion Criteria: Fall due to strong external force, new apoplexia cerebri, epileptic seizure, alcohol intoxication. Known cognitive impairment Not able to walk prior to fall Living in institution Planned geriatric intervention.

Ages Eligible for Study
-----------------
Minimum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Identification of individual risk factors for falls and specified intervention aimed diminishing these risk factors in the individual. | Other: multifactorial intervention<br>* Identification of medical, cardiovascular, physical risk factors for falls; e.g. vision, drug-use, depression, carotid sinus syndrome, orthostatic hypotension, etc. Individual intervention; treatment of disease, drug review, pacemaker, exercises, new glasses, all if indicated.<br>|
| Placebo Comparator: 2<br>Usual care | Other: Usual care<br>* No intervention, but ususal care after an accidental fall.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of falls and injurious falls in 12 months |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Health related Quality of Life |  |  | 
| Fear of falling |  |  | 
| Dependence |  |  | 
| Use of hospital, primary care etc. |  |  | 
| Mortality |  |  |
Chest CT for the Placement of the Uniblocker

Study Overview
=================
Brief Summary
-----------------
Video laryngoscope and chest CT iminge for the placement of the Uniblocker

Detailed Description
-----------------
Comparing the traditional method of Uniblocker intubation and video laryngoscope combined with chest CT iminge guide the precise localization of Uniblocker

Official Title
-----------------
Placement of the Uniblocker Under the Guidence of Chest Computerized Tomography

Conditions
-----------------
Therapeutic Procedural Complication

Intervention / Treatment
-----------------
* Device: video laryngoscope and chest CT iminge
* Device: Conventional intubation of uniblocker


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: BMI less than 35 kg/m2 ASA classifications of I-III, Modified Mallampati classification 1 or 2 Under general anesthesia Exclusion Criteria: Age younger than 18 yr or older than 65 yr ASA class IV or V Abnormalities of the heart, brain, liver, lung, kidney and coagulation functions

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: video laryngoscope and chest CT iminge<br>First,the operator calculate the distance between the carina and the glottis by CT image and make a marker on the Uniblocker. Then the operator inserted the Uniblocker into the trachea and advanced toward the left main-stem bronchus via the video laryngoscope untill see marker just at the glottis then stopped the insertion .Second, a single lumen tube with appropriate size was intubated via video laryngoscope into the appropriate depth.Third,the Fiberoptic bronchoscopy(FOB) was inserted into single lumen tube to assess the position of the Uniblocker and the injuries of bronchi and carina | Device: video laryngoscope and chest CT iminge<br> <br> |
| Experimental: Conventional intubation of Uniblocker<br>First, a conventional single lumen tube (SLT) was inserted into trachea at optimal depth via video laryngoscope. Second, a Uniblocker was inserted through SLT and directed to the left main-stem bronchus. Third, an FOB was inserted into the SLT to adjust the Uniblocker to optimal position and assessed the injuries of bronchi and carina. | Device: Conventional intubation of uniblocker<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intubation Time |  | 5min |
CTEPH DIAGNOSIS Europe - MRI

Study Overview
=================
Brief Summary
-----------------
Phase III diagnostic trial to demonstrate that functional lung MRI can replace VQ-SPECT in a diagnostic strategy for patients with suspected CTEPH where positive findings are verified with catheter pulmonary angiography (CPA), or computed tomography pulmonary angiography (CTPA)

Detailed Description
-----------------
CHANGE-MRI is a prospective, multicentre, comparative phase III diagnostic study. The study aims to show via an in-place validation that MRI can replace VQ-SPECT as a screening test for chronic pulmonary embolism in the diagnostic algorithm for CTEPH. The diagnostic gold standard is catheter pulmonary angiography (CPA) or computed tomography pulmonary angiography (CTPA) with correction from the clinical outcome after 6-12 months.

Official Title
-----------------
CHANGE-MRI (CTEPH DIAGNOSIS Europe - MRI)

Conditions
-----------------
Pulmonary Hypertension

Intervention / Treatment
-----------------
* Other: Index test: functional dynamic contrast enhanced (DCE)-MRI


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Transthoracic echocardiography indicates pulmonary hypertension Patients with clinical suspicion for CTEPH, scheduled for SPECT Provided informed consent for the study Age >18y Exclusion Criteria: Patient unable to undergo MRI (e.g. due to claustrophobia, cardiac pacemaker, hypersensitivity to MR i.v. contrast imaging agents) Women who are pregnant or breast feeding

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Index test: functional dynamic contrast enhanced (DCE)-MRI<br>Patients with clinical suspicion for CTEPH, scheduled for SPECT | Other: Index test: functional dynamic contrast enhanced (DCE)-MRI<br>* Index test: functional dynamic contrast enhanced (DCE)-MRI Reference test: Ventilation-perfusion (VQ) single-photon emission computed tomography (SPECT) Follow-up per patient: clinical assessment after 6-12 months<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The proportion of patients with positive MRI in the group of patients who have a positive VQ-SPECT diagnosis for chronic pulmonary embolism and who are positive in the gold standard |  | 6 months | 
| The proportion of patients with positive MRI in the group of patients with negative VQ-SPECT who are negative in the gold standard |  | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Chronic Thromboembolic Pulmonary Hypertension (CTEPH), MRI, SPECT
Effect of CP-778,875 on HDL-C in Subjects With Abnormal Lipid Levels and Type 2 Diabetes.

Study Overview
=================
Brief Summary
-----------------
To assess the effect of CP-778,875 on HDL-C cholesterol in adult subjects with dyslipidemia and type 2 diabetes

Official Title
-----------------
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study To Evaluate The Effect Of CP-778,875 On HDL-Cholesterol In Adult Subjects With Dyslipidemia And Type 2 Diabetes Mellitus

Conditions
-----------------
Dyslipidemia

Intervention / Treatment
-----------------
* Drug: CP-778,875


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: HDL-C < or = 45 mg/dL for men and < or = 55 mg/dL for women Triglycerides between 150-500 mg/dL Fasting Plasma Glucose 140-240 mg/dL Exclusion Criteria: Known cardiovascular, carotid, or peripheral vascular disease

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: CP-778,875|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HDL-C Safety and Efficacy |  |  |