Understanding Barriers to Initiation and Adherence to Endocrine Therapy in Young Breast Cancer Survivors of Diverse Backgrounds

Study Overview
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Brief Summary
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The overall goal of this study is to qualitatively explore how behavioral, cultural, psychosocial, and economic barriers and facilitators affect the decision to start and adhere to endocrine therapy (ET) among young breast cancer survivors of diverse racial, ethnic, and socio-economic backgrounds with hormone receptor positive (HR+) breast cancer

Detailed Description
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A qualitative study that will use interviews to gain an in depth understanding of factors affecting the decision to start and adhere to endocrine therapy (ET) among young breast cancer survivors of diverse racial, ethnic, and socio-economic backgrounds with hormone receptor positive (HR+) breast cancer

Official Title
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Understanding Barriers to Initiation and Adherence to Adjuvant Endocrine Therapy in Young Breast Cancer Survivors of Diverse Racial, Ethnic, and Socio-economic Backgrounds: The EMPOWER Study

Conditions
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Breast Cancer

Intervention / Treatment
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* Other: Phone interview


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Are Hispanic, Latina, Black, or identify as socio-economically disadvantaged (any racial/ethnic background) as measured by an item of financial distress answering that they are having difficulty paying the bills no matter what they do to a question about their current household financial situation.18, 19 report a history of Stage 1-3 breast cancer reports HR+ breast cancer and confirm that they have had a discussion with their doctor about adjuvant ET; OR indicate that they are taking ET, even if they do not know their HR status, answer they are HR-, or do not recall having a discussion about ET) not in active treatment (e.g., chemotherapy, radiation), with the exception of Herceptin at least 3 months, but no more than 3 years out of completion of active treatment no evidence of recurrent/metastatic disease at least 18, but< 45 years of age at diagnosis of first invasive breast cancer English or Spanish speaking are willing to consent to the interview Exclusion Criteria: HR- breast cancer and indicate they are not taking ET HR+ breast cancer but do not confirm discussion of ET or indicate they are taking ET Stage 0 (DCIS) breast cancer Recurrent or metastatic disease Less than 3 months or more than 3 years post-active treatment Less than 18 years old or ≥45 years old at diagnosis

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Quality Of Life<br>This study uses qualitative research methods, specifically semi-structured interviews. This will include moderator guide development, Phone interviews with breast cancer survivors will be conducted Qualitative data analysis of the phone interviews will be conducted | Other: Phone interview<br>* Collecting clinical and socio-demographic information.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Decision-making around endocrine therapy in young women with HR+ breast cancer. | Open ended questions | 3 months-3 years post active treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Barriers and challenges to endocrine therapy adherence | Open ended questions | 3 months-3 years post active treatment | 
| Social support | Open ended questions | 3 months-3 years post active treatment | 
| Health behaviors | Open ended questions | 3 months-3 years post active treatment | 
| Endocrine therapy adherence intervention preferences | Open ended questions | 3 months-3 years post active treatment | 
| Health literacy | Brief Health Literacy Screener (Chew items) | 3 months-3 years post active treatment | 
| Menopausal symptoms | BCPT Symptom Checklist | 3 months-3 years post active treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Breast Cancer