Evaluating of Role of Myeloperoxidase in Prediction of Outcomes of Cardiac Surgery Procedures.

Study Overview
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Brief Summary
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The main objection is to investigate molecular biology of myocardial damage during cardiac surgery procedures.

Detailed Description
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To assess outcomes after cardiac surgery procedures. To investigate serum level of myeloperoxidase, morphology of left atrium appendage, to perform genetic analysis and cell biology.

Official Title
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Evaluating of Role of Myeloperoxidase in Prediction of Outcomes of Cardiac Surgery Procedures.

Conditions
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Cardiac Procedure Complication, Ischemic Heart Disease, Valve Heart Disease, Defect Septal

Intervention / Treatment
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* Other: On-pump CABG
* Other: Off-pump CABG
* Other: Pump-assisted CABG
* Other: Valve Repair Procedure without CABG.
* Other: Valve Repair Procedure with CABG.


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ischemic heart disease with indications for operation valve disease with indications for operation ischemic heart disease combined with valve disease with indications for operation Exclusion Criteria: patient refusal
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: On-pump CABG.<br>On-pump CABG. | Other: On-pump CABG<br>* On-pump CABG<br>|
| Other: Off-pump CABG.<br>Off-pump CABG. | Other: Off-pump CABG<br>* Off-pump CABG<br>|
| Other: Pump-assisted CABG.<br>Pump-assisted CABG. | Other: Pump-assisted CABG<br>* Pump-assisted CABG<br>|
| Other: Heart Valve Procedure without CABG.<br>Heart Valve Procedure without CABG. | Other: Valve Repair Procedure without CABG.<br>* Valve Repair Procedure without CABG (open heart procedure).<br>|
| Other: Heart Valve Procedure with CABG.<br>Heart Valve Procedure with CABG. | Other: Valve Repair Procedure with CABG.<br>* Valve Repair Procedure with CABG (open heart procedure).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Death within 30 days after procedure. | Death within 30 days after surgical procedure. | within 30 days after procedure. | 
| Acute myocardial infarction. | Acute myocardial infarction (ST-changes with troponin I > 10 ng/ml). | within 30 days after procedure. | 
| Stroke. | Stroke (MRI changes or corresponding neurologist record). | within 30 days after procedure. | 
| Arrhythmia | Any type of arrhythmia including AV-block. | within 30 days after procedure. | 
| Renal dysfunction. | Renal dysfunction if serum creatinine greater than 25% of upper reference range. | within 30 days after procedure. | 
| Infection or febrile. | Infection or febrile (t> 37 or CRP elevation or long regeneration of surgical wound). | within 30 days after procedure. | 
| Respiratory dysfunction. | Respiratory dysfunction (pulmonary ventilation longer than 2 days). | within 30 days after procedure. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ischemic Heart Disease, Valve Disease, Septal Defect, Myeloperoxidase, Molecular biology, Gene analysis