Cardiac MRI for the Detection of Myocardial Injury Following Acute Kidney Injury

Study Overview
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Brief Summary
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The aim of this clinical prospective study is to assess structural and functional myocardial changes in patients after acute kidney injury (Cardiorenal syndrome type 3) and intensive care stay by multiparametric cardiac MRI.

Detailed Description
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The aim of the study is to demonstrate any differences in myocardial structure and function using multiparametric cardiac MRI in patients after acute kidney injury (Cardiorenal syndrome type 3) and intensive care stay and subsequent convalescence compared to a control group with intensive care stay but without kidney injury. Furthermore, the correlation between clinical disease severity and cardiac involvement will be investigated.

Official Title
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Multiparametric Cardiac MRI for the Detection and Quantification of Myocardial Injury Following Acute Kidney Injury (Cardiorenal Syndrome Type 3)

Conditions
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Acute Kidney Injury, Cardio-Renal Syndrome, Cardiomyopathies

Intervention / Treatment
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* Diagnostic Test: Cardiac magnetic resonance scan


Participation Criteria
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Eligibility Criteria
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Inclusion criteria: acute kidney injury and convalescence (GFR > 45 ml/min/1.73m²). patients who are 18 years of age or older Exclusion criteria: underlying cardiac disease, e.g. known myocardial infarction, previous myocarditis, congenital heart disease, cardiomyopathies of other causes known underlying disease wit potential cardiac involvement, e.g. storage disease (e.g. hemochromatosis, Fabry disease), inflammatory (e.g. sarcoidosis), endocrinological (e.g. diabetes mellitus, hyper-/hypothyroidism), autoimmune (e.g. systemic lupus erythematosus, dermatomyositis, rheumatoid arthritis), therapeutic (chemotherapy). patients with persistent renal failure and GFR < 45 ml/min/1.73m² allergy to contrast media patients who are using a intrauterinpessare for contraception pregnant and breastfeeding women patients with contraindications for MRI due to implants

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Intensiv care patients after acute kidney injury<br>Patients with condition after intensive care stay and acute kidney injury and subsequent convalescence (without preexisting underlying cardiac disease or other disease with potential cardiac involvement). | Diagnostic Test: Cardiac magnetic resonance scan<br>* Multiparametric cardiac magnetic resonance, including functional and structural parameter<br>|
| Intensiv care patients without kidney injury<br>Patients with condition after intensive care stay and subsequent convalescence (without kidney injury and preexisting underlying cardiac disease or other disease with potential cardiac involvement). | Diagnostic Test: Cardiac magnetic resonance scan<br>* Multiparametric cardiac magnetic resonance, including functional and structural parameter<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Myocardial T1 relaxation time | T1 relaxation times will be obtained to asses acute myocardial injury and fibrosis. T1 maps will be analyzed using a segmental approach by region of interest analysis. T1 relaxation times are given in [ms]. | Measurement will be performed within 2 weeks after MRI scan. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Myocardial T2 relaxation time | T2 relaxation times will be obtained to asses myocardial edema. T2 maps will be analyzed using a segmental approach by region of interest analysis. T2 relaxation times are given in [ms]. | Measurement will be performed within 2 weeks after MRI scan. | 
| Myocardial ECV | Myocardial extracellular volume will be obtained to asses extracellular space/myocardial fibrosis. ECV values will be calculated using a segmental approach by region of interest analysis of native and contrast-enhanced T1 relaxation maps. ECV values are given in [%]. | Measurement will be performed within 2 weeks after MRI scan. | 
| Myocardial strain | Cardiac magnetic resonance feature-tracking will be used to asses left ventricular longitudinal, circumferential and radial strain. | Measurement will be performed within 2 weeks after MRI scan. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cardiac MRI