Use of Hyaluronic Acid Injection in Lateral Patellar Compression With Femoral Condylar Degenerative Changes After Arthroscopic Release

Study Overview
=================
Brief Summary
-----------------
Ninety patients are involved in this study, who underwent arthroscopic lateral patellar release for lateral patellar compression syndrome and they had patellofemoral degenerative lesion, which diagnoses by MRI preoperatively and proved by arthroscopic examination to be early stages of degenerative changes with no loss of articular surface. The patients were divided in to two groups (A and B). Group A (45 patients) were treated by local injection of Hyaluronic acid intraarticularly, and Group B (45 patients) were no injection intraarticular.

Detailed Description
-----------------
This study was done by one orthopedic surgeon in two hospitals. Ninety patients are involved in this study, who underwent arthroscopic lateral patellar release for lateral patellar compression syndrome and they had patellofemoral degenerative lesion, which diagnoses by MRI preoperatively and proved by arthroscopic examination to be early stages of degenerative changes with no loss of articular surface. The patients were divided in to two matched groups (A and B) regarding the age and gender; Group A (45 patients) were treated by local injection of Hyaluronic acid intraarticularly, 2 weeks after arthroscopy and were followed by VAS of knee pain for one year at (3) months, (6) months and (12) months, and Group B (45 patients) were no injection intraarticular. The study started on June (2017) and ends on March (2020). injection of Hyaluronic acid was used and followed in the same way. All patients presented with anterior knee pain which failed to respond to conservative treatment for 6 weeks or recurrent of symptoms after stopping of conservative treatment which involved changes of life style and NSAID. MRI done for all patients before operation.

Official Title
-----------------
Use of Hyaluronic Acid Injection After Arthroscopic Lateral Release in Patellar Compression Syndrome With Degenerative Cartilage Changes: Randomized Control Trial

Conditions
-----------------
Anterior Knee Pain Syndrome

Intervention / Treatment
-----------------
* Device: Hyaluronic acid injection
* Device: No injection of Hyaluronic acid


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Lateral patellar compression syndrome Exclusion Criteria: Patellar instability. Smoking. Diabetes Mellitus. Previous knee surgery.

Ages Eligible for Study
-----------------
Minimum Age: 26 Years
Maximum Age: 47 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Knee arthroscopy with Hyaluronic acid injection<br>Those patients who received hyaluronic acid injection | Device: Hyaluronic acid injection<br>* Injection of Hyaluronic acid in knees of those who has degenerative changes after arthroscopic treatment of lateral patellar compression syndrome<br>|
| Active Comparator: Knee arthroscopy without Hyaluronic acid injection<br>Knee arthroscopy who did not Hyaluronic acid injection | Device: No injection of Hyaluronic acid<br>* No injection of Hyaluronic acid was done<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual analogue score of knee pain | Visual analogue score of knee pain describe knee pain from degree 0 where no pain to degree 10 where is severe pain | The VAS for knee pain was measured 24 months after operation | 
| Kujala score | Kujala score questionnaire up to 100 | Preoperative assessment and 2 year postoperatively | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hyaluronic acid injection, Knee Arthroscopy, lateral patellar retinaculae., lateral patellar compression syndrome