Effect of Retrograde Autologous Blood Priming on Pulmonary Mechanics in Pediatric Cardiac Surgery

Study Overview
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Brief Summary
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The present study hypothesized that beyond its hemodynamic affects,retrograde autologus blood priming of cardiopulmonary bypass (RAP) has a positive impact on hemodynamics and pulmonary mechanics subjected to cardiac surgery.

Detailed Description
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This prospective randomized study analyzed the clinical records of 124 children subjected to cardiac surgery for congenital heart diseases with left to right shunt. They comprised 64 patients with RAP and 60 patients conventional cardiopulmonary bypass priming. The preoperative, intraoperative and postoperative data of the studied patients were reported.

Official Title
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Effect of Retrograde Autologous Blood Priming of Cardiopulmonary Bypass on Hemodynamic Parameters and Pulmonary Mechanics in Pediatric Cardiac Surgery

Conditions
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Congenital Heart Disease

Intervention / Treatment
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* Procedure: Pediatric cardiac surgery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: children complained of congenital heart disease with left to right shunt pressure or volume load Exclusion Criteria: cyanotic heart disease

Ages Eligible for Study
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Minimum Age: 12 Months
Maximum Age: 5 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Patients were included in the study if they had left to right shunt due to volume or pressure overload
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Retrograde priming<br>retrograde autologous Blood Priming of Cardiopulmonary Bypass (RAP) in young children subjected to cardiac surgery for congenital heart defects with left to right shunt associated with volume or pressure overload. | Procedure: Pediatric cardiac surgery<br> <br> |
| Active Comparator: conventional priming<br>conventional cardiopulmonary priming in young children subjected to cardiac surgery for congenital heart defects with left to right shunt associated with volume or pressure overload. | Procedure: Pediatric cardiac surgery<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of postoperative peak air way pressure between the studied groups | peak air way pressure (Paw) in cmH2O | 1 hour after surgery | 
| Comparison of postoperative air way resistance between the studied groups | air way resistance (Raw) in cmH2O/L/sec. | 1 hour after surgery | 
| Comparison of postoperative Plateau pressure between the studied groups | Plateau pressure in cm H2O | 1 hour after surgery | 
| Comparison of postoperative Lung compliance between the studied groups | Lung compliance in L/cm H2O | 1 hour after surgery | 
| Comparison of postoperative Tidal volume between the studied groups | Tidal volume in ml | 1 hour after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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retrograde autologous priming pulmonary mechanics