The Relationship Between Urine Iodine, Urine Bisphenol A and Autoimmune Thyroid Disease in Reproductive Women

Study Overview
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Brief Summary
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Autoimmune thyroid disease (AITD) is the main cause of hypothyroidism in reproduction women, iodine and bisphenol A are the environmental factors for AITD. The research was mainly designed to investigate the effect of iodine and BPA on AITD in reproduction women to provide new evidence for hypothyroidism in reproduction women.

Detailed Description
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71 patients with thyroid autoantibody positive were treated as AITD group, another 71 healthy reproduction women were selected as normal group. Women age, BMI, thyroid disease history, family history, marital and reproductive history, whether the application of iodized salt, thyroid function and thyroid autoantibodies detection were recorded. Meanwhile urine iodine, urinary iodine/urinary creatinine, urine BPA and urinary BPA/creatinine were tested. The urine iodine and BPA levels of the two groups were compared. Taking AITD as the dependent variable, logistic regression was conducted to analyze whether urinary iodine and BPA were risk factors of AITD.

Official Title
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The Relationship Between Urine Iodine, Urine Bisphenol A and Autoimmune Thyroid Disease in Reproductive Women

Conditions
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The Effect of Iodine and BPA on AITD in Reproduction Women

Intervention / Treatment
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* Other: urinary iodine and urine BPA


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: AITD group: positive thyroid autoantibody (one thyroid autoantibody), normal thyroid function. Normal group: thyroid autoantibody negative, normal thyroid function. No previous history of hyperthyroidism or hypothyroidism, no history of thyroid surgery or I131 radiotherapy, and no thyroid hormone or anti-thyroid drugs were used. Exclusion Criteria: Patients with severe liver, kidney, heart and other important organ failure. Merger with other autoimmune diseases. Amiodarone, iodine contrast agent and other drugs affecting thyroid function are used.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| AITD group<br>Thyroid antibody positive and hypothyroidism | Other: urinary iodine and urine BPA<br>* urinary iodine and urine BPA<br>|
| normal group<br>Thyroid antibody negative and hypothyroidism | Other: urinary iodine and urine BPA<br>* urinary iodine and urine BPA<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of urinary iodine levels between the two groups | Urinary iodine levels were compared between patients with autoimmune thyroid disease and normal women. | 2019-2011 | 
| Comparison of urinary BPA levels between the two groups | Urinary BPA levels were compared between patients with autoimmune thyroid disease and normal women. | 2019-2011 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Influencing factors of autoimmune thyroid diseases. | Abnormal levels of iodine and PBA are influential factors in autoimmune thyroid disease. | 2019-2012 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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iodine, bisphenol A, autoimmune thyroid disease