Characterization of Reverse Triggering and Other Asynchronies in COVID-19 Patients Under Invasive Mechanical Ventilation

Study Overview
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Brief Summary
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Prospective observational trial in patients admitted to ICU diagnosed with COVID-19 requiring invasive mechanical ventilation. Characterization of Reverse Triggering asynchrony during the first 5 days of invasive mechanical ventilation and other asynchronies, and its correlation with different outcomes.

Official Title
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Characterization of Reverse Triggering and Other Asynchronies in COVID-19 Patients Under Invasive Mechanical Ventilation

Conditions
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Mechanical Ventilation Complication

Intervention / Treatment
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* Diagnostic Test: Asynchronies detection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients under invasive mechanical ventilation more than 24 hours and with a minimum of 48 hours of respiratory signals registered from the ventilator Diagnosis of COVID-19 Exclusion Criteria: less than 48 hours of data, age < 18 years admitted from other centers under invasive mechanical ventilation.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Asynchronies detection|Asycnhronies detection|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence and pattern of presentation of Reverse triggering in COVID-19 patients under invasive mechanical ventilation | To analyze the incidence of Reverse Triggering in the initial phases of invasive mechanical ventilation in COVID-19 patients | during the 5 first days of invasive mechanical ventilation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of Reverse Triggering related to the level of sedation in COVID-19 patients under invasive mechanical ventilation | To correlate the presence of Reverse Triggering with the level of sedation and use of neuromuscular blockers | From the day of mechanical ventilation initation up to 5 days or the last day of mechanical ventilation | 
| Reverse triggering and secondary asynchronies in COVID-19 patients under invasive mechanical ventilation | To analyze the incidence of breath stacking and ineffective efforts secondary to RT. | From the day of mechanical ventilation initiation up to 5 days | 
| Incidence and pattern of presentation of asynchronies in COVID-19 patients under invasive mechanical ventilation | To analyze the incidence of RT, ineffective efforts and double triggering throughout the period of invasive mechanical ventilation | Each day from the day of mechanical ventilation initiation until the day of mechanical ventilation withdrawal or up to 28 days | 
| Influence of asynchronies in different outcomes in in COVID-19 patients under invasive mechanical ventilation | To correlate the presence of asycnhronies and its type with duration of invasive mechanical ventilation, ICU length of stay and survival | Each day from the day of mechanical ventilation initiation until the end of invasive mechanical ventilation, ICU discharge and hospital discharge or up to 28 days |