Evaluation of the Renal Function in an Ultra-endurance Race.

Study Overview
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Brief Summary
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During ultra endurance events, athletes experience extreme physical and mental demands, sometimes at the limits of the adaptive response to human physiology. This is particularly true for the renal function, and some evidence for acute renal failure has already been shown, sometimes leading to dialysis. However, the precise mechanisms involved in acute renal failure in such ultra endurance races are not clearly elucidated. The aim of our study is to estimate glomerular filtration rate from serum and urinary creatinine and cystitin C at the beginning and at the end of a 110 km ultra endurance race. Our hypothesis is that during the ultra endurance race, renal function may be injured, with a risk for the athlete.

Official Title
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Renal Function Evaluation in an Ultra Endurance Race: On the Interest of Monitoring Specific Biomarkers to Asses Renal Risk.

Conditions
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Renal Insufficiency, Acute

Intervention / Treatment
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* Other: INFERNAL Intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age: At least 20 years old Athlete that is officially registered to the 110 km race (INFERNAL Trail des Vosges) Athlete informed by a member (MD) of the Medical Staff of the race. Athlete that gives and signes the informed consent to the research protocol Exclusion Criteria: Athlete with a known disease that needs the following medications: Medications influencing the renin-angiotensin-aldosteron system (angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, aldosteron receptor blockers) Diuretic drugs Anticoagulant drugs Non-steroidal anti-inflammatory drugs Athlete with a known thyroid disease (because of the influence on the serum cystatin level) Athlete with a know renal disease Athlete with a know inflammatory disease

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: INFERNAL Arm<br>The INFERNAL Arm will have serum and urinary dosage for creatinine and cystanin C at the beginning and at the end of the 110 km race. | Other: INFERNAL Intervention<br>* The intervention consists in serum and urinary dosage (creatinine and Cystatin C) at the beginning and the end of the 110 km race.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glomerular filtration rate | The glomerular filtration rate will be calculated from the serum and urinary creatinine and cystatin C dosage | 30 minutes at baseline (09.07.2017), and 30 minutes at the end of the 110 km race (2 or 3 days after baseline) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Renal failure, athlete, ultra endurance