Post-natal Depression and Chronic Stress

Study Overview
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Brief Summary
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The risk of emergence of a post natal depression is based on an interaction between a maternal psychic vulnerability and a chronic environmental context of stress. The PND appears as a relevant model for studying the mechanisms of chronic stress and vulnerability to psychological pathologies. This study aim to follow a cohort of pregnant women to determine the predictive psychobiological factors of the emergence of postnatal depression

Detailed Description
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The prevalence of postnatal depression is high in civilian settings (20%). In mechanistic terms, the risk of emergence of a post natal depression is based on an interaction between a maternal psychic vulnerability and a chronic environmental context of stress. The post natal depression appears as a relevant model for studying the mechanisms of chronic stress and vulnerability to psychological pathologies. On the one hand, the repetition of stressors during pregnancy corresponds to a natural chronic stress model of several months and thus allows to study the biological cost of responses to repeated stresses, and the adaptive mechanisms leading to From functional drift to psychic dysfunction. On the other hand, isolated vulnerability factors characterize a mirroring psychological profile of a Mindfulness type of functioning. Mindfulness or full consciousness has been described as a state of consciousness which results from intentionally, at the present moment, without judging the experience that unfolds moment by moment. This psychological resource has been associated with resilient or even resilient psychic functioning. This study aim to follow a cohort of pregnant women from the first trimester of pregnancies to 2 months after the delivery to determine the predictive psychobiological factors of the emergence of postnatal depression

Official Title
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Chronic Stress Protection for Post-natal Depression Prevention: An Exploratory Study

Conditions
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Depression, Postpartum

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Physiological pregnancy Follow-up of pregnancy in a participating maternity Female over 18 years Affiliated to a social security scheme Exclusion Criteria: Multiple pregnancy Psychiatric, neurological, or endocrine or autoimmune diseases Hormonal or psychotropic treatments

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| post natal depression | change in Edimbourg Post-Partum Depression scale at two months after labour delivery | baseline at three 3 months of pregnancy and two months after labour delivery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| allostatic load as a composite index including blood GABA, BDNF and 8iso-Prostaglandins and capillary cortisol + heart rate variability index | change in allostatic load two months after labour delivery | baseline at three 3 months of pregnancy and two months after labour delivery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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postnatal depression stress mindfulness allostatic load