Post-discharge Nutrition and Resistance Training in Surgical Patients

Study Overview
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Brief Summary
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Randomized intervention by nutritional supplements and training in postoperative patients after discharge

Detailed Description
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Surgery combined with malnutrition is associated with loss of muscle mass and leads to serious consequences for the surgical patient. A majority of surgical patients continue to lose weight after discharge. Nutritional risk screening has not been fully implemented at Landssjúkrahúsið - the National Hospital of the Faroe Islands and therefore the prevalence of patients at nutritional risk is unknown. The aim of this study is to examine whether an intervention with independent nutritional supplements or an intervention combining nutritional supplements and resistance training is more effective in preventing loss of muscle mass than standard care in surgical patients following discharge. Secondary outcomes are changes in body weight, quality of life, muscle strength and activities of daily living. Furthermore, we want to screen hospitalized surgical patients for nutritional risk in order to get an estimate of the prevalence of nutritional risk.

Official Title
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Malnutrition in Surgical Patients in the Faroe Islands: Post-discharge Nutrition and Resistance Training

Conditions
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Malnutrition, Surgery

Intervention / Treatment
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* Dietary Supplement: Nutrition


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Admitted to the surgical departments at Landssjúkrahúsið - National Hospital of Faroe Islands Aged 18 years or above One or more of the following surgical procedures: knee alloplasty, hip alloplasty, collum femoris fracture, back fracture, abdominal surgery, mamma surgery and other comprehensive surgery At nutritional risk according to screening Exclusion Criteria: Minimally invasive surgery/Laparoscopic surgery Severely reduced kidney function (p-creatinin>250 mikromol/l) or dialysis Terminal illness Inability to cooperate in tests or exercises due to cognitive function or dementia Admitted to intensive care unit Inability to speak or understand Faroese, Danish or English Consent according to national regulations not obtainable

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: 3 groups of 50 patients each by randomization
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Nutrition<br>Oral nutritional supplements and dietetic advice | Dietary Supplement: Nutrition<br>* 150 Faroese surgical patients randomized to one of the following three arms 1) oral nutritional supplements and advice, 2) oral nutritional supplements and training exercise and 3) Standard hospital procedure. Primary outcome is loss of lean body mass<br>|
| Experimental: Nutrition and exercise<br>Oral nutritional supplements, dietetic advice and exercise training | Dietary Supplement: Nutrition<br>* 150 Faroese surgical patients randomized to one of the following three arms 1) oral nutritional supplements and advice, 2) oral nutritional supplements and training exercise and 3) Standard hospital procedure. Primary outcome is loss of lean body mass<br>|
| No Intervention: Control<br>Standard Hospital Procedure | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Loss of lean body mass | Non-bone lean mass measured by dual energy x-ray absorptiometry (DXA) whole-body scans | 8 weeks |