Medication Adherence in Psoriatic Arthritis

Study Overview
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Brief Summary
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Psoriatic arthritis (PsA) is a chronic multisystemic disease requiring ordinary doctor visits and an adherence to medication. Evaluating the parameters affecting the medication adherence is essential for the efficacy of the treatment. To our knowledge no study has ever evaluated the factors affecting the medication adherence in patients with PsA so far.

Detailed Description
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Psoriatic arthritis (PsA) is a multisystemic disease requiring ordinary doctor visits and an adherence to medication. Due to its chronic nature treatment regimens lasts for the lifetime and that may affect the efficacy of the treatment. Although treatment with drugs is a biological intervention, medication adherence and eliminating the factors affecting it seems essential for treatment efficacy. To our knowledge no study has ever evaluated the factors affecting the medication adherence in patients with PsA so far. Our aim in this study is to evaluate the factors affecting the medication adherence in patients with PsA.

Official Title
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Self-Reported Medication Adherence in Patients With Psoriatic Arthritis: Influence of Illness Perception and Medication Beliefs

Conditions
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Psoriatic Arthritis

Intervention / Treatment
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* Other: Disease activity in psoriatic arthritis (DAPSA)
* Other: Compliance-Questionnaire-Rheumatology (CQR)
* Other: The Brief Illness Perception Questionnaire (BIPQ)
* Other: The Beliefs About Medicines Questionnaire (BMQ)
* Other: Hospital Anxiety and Depression Scale (HADS)
* Other: The Psoriatic Arthritis Quality of Life (PsAQoL)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosed with PsA according to CASPAR criteria Administering PsA medication for at least 6 moths Aged ≥18 Exclusion Criteria: Not having enough cognitive functions to understand and answer the questionnaires Having a psychiatric disorder Having a severe comorbidity (e.g. malignancy, stroke)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Psoriatic arthritis<br>Patients with psoriatic arthritis according to the Classification Criteria for Psoriatic Arthritis (CASPAR). | Other: Disease activity in psoriatic arthritis (DAPSA)<br>* DAPSA includes a 68/66 joint count summed with a patient global, patient pain score, and C- reactive protein level. The DAPSA provides a continuous score of arthritis activity and has validated cut points for remission (< 4) and low disease activity (< 14).<br>Other: Compliance-Questionnaire-Rheumatology (CQR)<br>* The CQR is a self-administered questionnaire that was developed with the aim of correctly identifying patients that were classified as low adherers (taking <80% of their medication correctly). The four point Likert answering scale ranges from; Definitely don't agree (scored 1) to Definitely agree (scored 4) with lower scores indicating lower levels of adherence. Total score is between 0 and 100.<br>Other: The Brief Illness Perception Questionnaire (BIPQ)<br>* The Brief Illness Perception Questionnaire (BIPQ) is a questionnaire that assesses a number of beliefs about illness which are thought to be related to coping and help-seeking behavior. Each item is scored between 0 and 10. Maximum total score is 80. Higher scores represents that the patient has a concerned perception of illness.<br>Other: The Beliefs About Medicines Questionnaire (BMQ)<br>* The Beliefs About Medicines Questionnaire (BMQ) is a tool for evaluating people's beliefs about medicines. The BMQ comprises two sections: the BMQ-Specific which assesses representations of medication prescribed for personal use and the BMQ-General which assesses beliefs about medicines in general. It has a total of 18 questions scored with a 5-point Likert scale. Higher scores represent more powerful beliefs.<br>Other: Hospital Anxiety and Depression Scale (HADS)<br>* Hospital Anxiety and Depression Scale (HADS) determines the levels of anxiety and depression that a person is experiencing. The HADS is a fourteen item scale that generates: Seven of the items relate to anxiety and seven relate to depression. Each item on the questionnaire is scored from 0-3 and this means that a person can score between 0 and 21 for either anxiety or depression.<br>Other: The Psoriatic Arthritis Quality of Life (PsAQoL)<br>* The Psoriatic Arthritis Quality of Life (PsAQoL) measure is a disease specific patient-reported outcome measure which measures the effect that psoriatic arthritis has on a patient's quality of life. It is a self-administered, 20-item questionnaire that takes about three minutes to complete. The answers are restricted to true or false.A high score on the PsAQoL indicates a lower quality of life. Total score is between 0 and 20.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disease activity in psoriatic arthritis (DAPSA) | The score of Disease activity in psoriatic arthritis (DAPSA) provides a continuous score of arthritis activity and has validated cut points for remission (< 4) and low disease activity (< 14). Higher scores represent a worse outcome. | 1 day | 
| Compliance-Questionnaire-Rheumatology (CQR) | The CQR is a self-administered questionnaire that was developed with the aim of correctly identifying patients that were classified as low adherers (taking <80% of their medication correctly). The four point Likert answering scale ranges from; Definitely don't agree (scored 1) to Definitely agree (scored 4) with lower scores indicating lower levels of adherence. Total score is between 0 and 100. | 1 day | 
| The Brief Illness Perception Questionnaire (BIPQ) | The Brief Illness Perception Questionnaire (BIPQ) is a questionnaire that assesses a number of beliefs about illness which are thought to be related to coping and help-seeking behavior. Each item is scored between 0 and 10. Maximum total score is 80. Higher scores represents that the patient has a concerned perception of illness. | 1 day | 
| The Beliefs About Medicines Questionnaire (BMQ) | he Beliefs About Medicines Questionnaire (BMQ) is a tool for evaluating people's beliefs about medicines. The BMQ comprises two sections: the BMQ-Specific which assesses representations of medication prescribed for personal use and the BMQ-General which assesses beliefs about medicines in general. It has a total of 18 questions scored with a 5-point Likert scale. Higher scores represent more powerful beliefs. Total score ranges from 4 to 20 | 1 day | 
| Hospital Anxiety and Depression Scale (HADS) | Hospital Anxiety and Depression Scale (HADS) determines the levels of anxiety and depression that a person is experiencing. The HADS is a fourteen item scale that generates: Seven of the items relate to anxiety and seven relate to depression. Each item on the questionnaire is scored from 0-3 and this means that a person can score between 0 and 21 for either anxiety or depression. | 1 day | 
| The Psoriatic Arthritis Quality of Life (PsAQoL) | The Psoriatic Arthritis Quality of Life (PsAQoL) measure is a disease specific patient-reported outcome measure which measures the effect that psoriatic arthritis has on a patient's quality of life. It is a self-administered, 20-item questionnaire that takes about three minutes to complete. The answers are restricted to true or false.A high score on the PsAQoL indicates a lower quality of life. Total score is between 0 and 20. | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Psoriatic Arthritis, Medication Adherence