Oxytocin and Incitement to Use Olfactory Stimuli in Restrictive Anorexia Nervosa

Study Overview
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Brief Summary
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This prospective pilot study will compare adolescents with restrictive anorexia nervosa who participated for 3 months at olfactory workshops, patients who did not, and healthy patients.The groups will be evaluated before the workshops and after three months, with the wanting score after olfactory stimuli and with serum oxytocin level.

Detailed Description
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The restrictive anorexia nervosa (AN) in adolescents is an eating disorder with decreased desire to eat (wanting) following olfactory stimulation. Oxytocin is an hormone involved in the neuromodulation of eating behavior, but also involved in olfactory perception in schizophrenia patients, and in social cognition in patients with autism. Its plasma level was found low in anorexic patients compared to control subjects. Because of the similarity in disorders of social cognition between these three diseases, we assume that the desire to eat evoked by olfactory perception varies with the plasma oxytocin levels. With a prospective pilot study we will compare patients with AN who participated for 3 months at olfactory workshops, AN patients who did not, and healthy patients. The groups will be evaluated before the workshops and after three months, with the wanting score after olfactory stimuli and with serum oxytocin level. One application of this study will be the use of ocytocyne nasal spray to increase the eating desire and to allow weight regain

Official Title
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Pilot Study: a Comparative Study Between Serum Levels of Oxytocin and Incitement to Use Olfactory Stimuli in Restrictive Anorexia Nervosa in Adolescents

Conditions
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Anorexia

Intervention / Treatment
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* Other: olfactory workshop
* Other: other workshop
* Other: No intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Medical-Review Female or male -Sexe, 11 to 18 years Anorexia nervosa diagnosed according to the criteria DSM V Outpatient care or hospitalization Be able to answer the clinicals evaluations questionnaires Affiliated to social security Consentement of the legal representative and the patient Exclusion Criteria: Somatic comorbidity associated with diabetes, celiac disease, brain tumor Intolerance odors, predisposed to develop asthma and / or respiratory allergies Pathologie chronic rhino-sinus Hyposmiques or anosmic Patients not of an inclusion criteria

Ages Eligible for Study
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Minimum Age: 11 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: olfactory workshop<br>Influence of sensory therapy on the rate of oxytocin | Other: olfactory workshop<br>* olfactory workshop<br>|
| Active Comparator: other workshop<br>Influence of other workshop on the rate of oxytocin | Other: other workshop<br>* other workshop: discussion group, dance and body Expression<br>|
| Other: control group<br>Rate of oxytocin of the control group | Other: No intervention<br>* control group<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Score Wanting to olfactory stimuli |  | at 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Oxytocin serum level |  | at 3 months | 
| Body mass index |  | at 3 months | 
| Scores to clinical scales |  | at 3 months | 
| Scores to hedonicity scale |  | at 3 months | 
| Scores to liking-wanting tests |  | at 3 months |