Efficacy Study of a Low Volume of Water Intake and Mosapride for Endoscopy in Patients With Subtotal Gastrectomy

Study Overview
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Brief Summary
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A low volume of water intake and mosapride will effectively reduce food residue in remnant stomach for patients who had undergone subtotal gastrectomy due to gastric cancer.

Detailed Description
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We evaluate that a 500mL of water intake and mosapride will effectively reduce food residue in remnant stomach for patients who had undergone subtotal gastrectomy due to gastric cancer. We plan to compare this method with routine midnight fasting method for endoscopy in patients with subtotal gastrectomy.

Official Title
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Efficacy of a Low Volume of Water Intake and Mosapride for Endoscopy Preparation in Gastric Cancer Patients With Subtotal Gastrectomy: A Randomized Controlled Trial

Conditions
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Foreign Body Left During Endoscopic Examination

Intervention / Treatment
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* Drug: Mosapride


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Outpatients who had subtotal gastrectomy for gastric cancer Exclusion Criteria: Pregnancy Lactation History of anastomotic stricture Recurrent advanced gastric cancer Poor general condition( > 2 ECOG) Other disseminated malignancy Significant renal failure or congestive heart failure (CHF) Liver failure

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: midnight fasting<br>The patients in this group will have midnight fasting the day before endoscopic examination | |
| Active Comparator: Mosapride, low volume of water<br>The patients in this group will take mosapride and a 500mL water at evening of the day before endoscopic examination. | Drug: Mosapride<br>* Mosapride 10mg, one dosage, once evening of the day before the endoscopy<br>* Other names: Gasmotin;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Degrees of food residue using endoscopic scoring system | We plan to evaluate how much a low volume of water and mosapride, compared with routine fasting, reduse food residue in gastric remnant for endoscopy. | six months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tolerability of a low volume of water and mosapride | We plan to evaluate tolerability of a low volume of water and mosapride compared with routine fasting for endoscopy preparation in patients with subtotal gastrectomy | six months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Gastrectomy, Endoscopy, Stomach neoplasms