Effects of Clinical Pilates and Whole Body Vibration Exercises in Postmenopausal Osteoporotic Women

Study Overview
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Brief Summary
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The aim is to compare the effects of clinical pilates and whole body vibration exercises in postmenopausal osteoporotic women on strength, flexibility, balance, bone turnover markers and quality of life.

Detailed Description
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The aim of this study is to compare the effects of clinical pilates and whole body vibration exercises in postmenopausal osteoporotic women in terms of strength, flexibility, balance, bone turnover markers and quality of life. Thirty-four women who are diagnosed with postmenopausal osteoporosis will be recruited into the study. Participants will be divided into two groups: (1) clinical pilates group, (2) vibration exercises group. Exercise programs will be performed two times per week for twelve weeks. The strength of the extensor muscles of the hip, knee, back, elbow will be measured with a hand-held dynamometer. Flexibility will be assessed measuring the fingertip-to-floor distance in flexion and lateral bending. The balance performance will be assessed using the timed up and go test, Tetrax fall index and the maximum hold time on unipedal stance and on tandem stance. The short form-12 questionnaire will be used to assess the quality of life. Also, bone turnover markers will be measured. All assessments will be performed before and after exercise programs.

Official Title
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Comparison of the Effects of Clinical Pilates and Whole Body Vibration Exercises on Strength, Flexibility, Balance, Bone Turnover Markers and Quality of Life in Postmenopausal Osteoporotic Women

Conditions
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Osteoporosis

Intervention / Treatment
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* Other: Clinical pilates
* Other: Whole body vibration


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Being in the postmenopausal period Having body mass index equal to or greater than 18,5 kg/m² A lack of regular exercise Having been diagnosed with osteoporosis Having the ability to walk independently Exclusion Criteria: Having a cardiopulmonary problem that may prevent participating in exercise programs Having kidney stones Being diagnosed with diabetes Presence of epilepsy Having cardiological problems such as arrhythmia, using a pacemaker, hypertension Having neurological disorders such as Parkinson, stroke, multiple sclerosis, neuropathy Having surgery in the last 6 months

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: A controlled study
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Clinical pilates<br>Exercises will be performed two times per week for twelve weeks. | Other: Clinical pilates<br>* Clinical pilates exercises will be performed progressively. The duration of each exercise session will be an average of 40 minutes initially and then will be increased to 60 minutes as the program progress.<br>|
| Experimental: Whole body vibration<br>Exercises will be performed two times per week for twelve weeks. | Other: Whole body vibration<br>* Whole body vibration exercises will be performed using the Power Plate pro5 AIRdaptive machine.The duration of each exercise session will be an average of 20 minutes initially and then will be increased to 30 minutes as the program progress.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Strength | The strength of the extensor muscles of the hip, knee, back, elbow will be assessed with a hand-held dynamometer. | Change in strength measures from baseline to twelve weeks | 
| Flexibility | Flexibility wil be assessed measuring the fingertip-to-floor distance in flexion and lateral bending. | Change in flexibility measures from baseline to twelve weeks | 
| Timed up and go test | Timed up and go test will be used to assess dynamic balance. | Change in Timed up and go test from baseline to twelve weeks | 
| The maximum hold time on unipedal stance and on tandem stance. | The maximum hold time will be calculated to assess static balance. | Change in the maximum hold time from baseline to twelve weeks | 
| Tetrax fall index | Tetrax fall index will be calculated to determine fall risk. | Change in Tetrax fall index from baseline to twelve weeks | 
| The short form-12 questionnaire | The short form-12 questionnaire will be used to assess quality of life. The total score can range from 0 to 100. Lower SF-12 score indicated poorer physical and mental health. | Change in quality of life measure from baseline to twelve weeks | 
| Dual-energy X-ray absorptiometry of hip and lumbar spine | Dual-energy X-ray absorptiometry of hip and lumbar spine will be measured to assess bone density. | Change in the Dual-energy X-ray absorptiometry of hip and lumbar spine from baseline to twelve weeks | 
| Plasma sclerostin concentration | Plasma sclerostin concentration will be measured to assess the process of bone resorption and formation. | Change in plasma sclerostin concentration from baseline to twelve weeks | 
| Urinary deoxypyridinoline | Urinary deoxypyridinoline level will be measured to assess bone resorption. | Change in urinary deoxypyridinoline level from baseline to twelve weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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postmenopausal osteoporosis, clinical pilates, whole body vibration, bone turnover markers, strength, flexibility, balance, quality of life