Biomarker Establishment for Superior Treatment of PTSD

Study Overview
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Brief Summary
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The purpose of Biomarker Establishment for Superior Treatment of PTSD is to accelerate research on the discovery of biological, neurological and neuroimaging markers for Post- Traumatic Stress Disorder (PTSD). The investigators hope to validate and extend the network efficiency and verbal memory biomarker for PTSD. The investigators hope to learn whether there are pretreatment biological factors that can predict response to therapy. They want to do this by understanding the brain network function, relating EEG to functional magnetic resonance imaging, and application of network analysis tool.

Official Title
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Biomarker Establishment for Superior Treatment of PTSD

Conditions
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PTSD

Intervention / Treatment
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* Other: Psychotherapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis of PTSD by VA clinicians and acceptance into PE or CPT treatment as part of the PCT Veterans of any era Exclusion Criteria: MRI safety contraindications Active, uncontrolled medical illness Acute suicidality Current substance dependence Current use of thyroid medication or active hyper/hypothyroidism Neurological disorder affecting the CNS Seg stroke, epilepsy, tumorW or penetrating head injury Use of PRN within 48 hours of the MRI/EEG

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Psychotherapy<br>The investigators will assess and acquire data on these Veterans across the course of the project prior to and after receiving Prolonged Exposure (PE) or Cognitive Processing Theory (CPT) treatment at VA Palo Alto (VAPAHCS) and the Albuquerque VA. They will acquire fMRI, behavioral, EEG, TMS/EEG, and saliva at baseline on these Veterans and again 3 months after treatment to assess prediction and durability of the clinical and brain/behavioral metrics. All study assessments will take place at Stanford University/VAPAHCS. Subjects will be recruited through VAPAHCS and Albuquerque VA. Subjects will complete a clinical assessment including: neuroimaging, self-report questionnaires completed via computer or paper-and-pencil, cognitive testing, saliva, and TMS and EEG assessments. | Other: Psychotherapy<br> <br> * Other names: Prolonged Exposure;|
| Healthy Controls<br>The investigators will assess and acquire data on these Veterans who do not have history of PTSD and have no history of any Axis I psychiatric disorder, are taking psychotropic medication, or use illicit drugs. They will acquire fMRI, behavioral, EEG, TMS/EEG, and saliva once. All study assessments will take place at Stanford University. Subjects will be recruited through public flying, online ads and VAPAHCS. Subjects will complete a clinical assessment including: neuroimaging, self-report questionnaires completed via computer or paper-and-pencil, cognitive testing, saliva, and TMS and EEG assessments. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Understanding the brain network function-neuroimaging and behavioral with Clinician-Administered PTSD Scale for DSM-5 | We will be using CAPS 5 | Approximately 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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veterans, post traumatic stress disorder, depression