Low FODMAP Diet in Patients With IBS

Study Overview
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Brief Summary
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We aimed to investigate if all carbohydrate groups eliminated in the Low FODMAP diet are equally important in relieving gastrointestinal symptoms in IBS. in a randomised cross-over design to three different carbohydrate-modified diets: A) Low Polyol diet, B) Low FOS+GOS diet, and C) Low FODMAP diet for three months without wash-out-periods. Gastrointestinal symptoms, Quality of life was measured at baseline and after each intervention diet.

Detailed Description
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Low FODMAP diets contain 3 major types of carbohydrates to be avoided. The clasical diet is very difficult to maintain over longer periods of time. Therefore, we aimed to investigate if all carbohydrate groups in the Low FODMAP diet are equally important in relieving gastrointestinal symptoms in IBS. Patients diagnosed with IBS according to the Rome III criteria were randomised in a cross-over design to three different carbohydrate-modified diets: A) Low Polyol diet, B) Low FOS+GOS diet, and C) Low FODMAP diet for a total of three months without wash-out-periods. Gastrointestinal symptoms were assessed by the Birmingham IBS questionnaire and adequate relief (IBS-AR). Quality of life was measured by the IBS Quality of Life Scale questionnaire (IBS-QOL). All registrations were performed at baseline and after each intervention diet.

Official Title
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Modification of the Low FODMAP Diet in Treatment of Irritable Bowel Syndrome: A Randomised Cross-over Study

Conditions
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Irritable Bowel Syndrome

Intervention / Treatment
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* Other: variations of the low FODMAP diet


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: IBS diagnosed by the Rome III criteria and referred to treatment by diet - Exclusion Criteria: Dementia, and lack of ability to speak Danish or other conditions prevailing participation -

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: Cross-over of 3 variations of the low FODMAP diet excluding 1 of the 3 components in every period
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: low FODMAP diet<br>Cross-over design with 3 variations | Other: variations of the low FODMAP diet<br>* Cross-over of 3 interventions in IBS patients: Low Polyol diet Low FOS+GOS diet Low FODMAP diet<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Birmingham IBS questionnaire and adequate relief (IBS-AR). | Score in points | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| IBS Quality of Life Scale questionnaire (IBS-QOL) | Score in points | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Carbohydrates, low FODMAP diet, components in the low FODMAP diet