Effect of Intraoperative Neuromuscular Blockade on Postoperative Sore Throat and Hoarseness

Study Overview
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Brief Summary
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Investigators assess and compare postoperative sore throat and hoarseness in the group using the muscle relaxant and not using it during the operation.

Detailed Description
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The muscle relaxant is usually used during the operation to maintain moderate relaxation but, it can't be used in the surgery to need eletrophysiological monitoring during the operation. In this sturdy, the investigators assess the postoperative sore throat and hoarseness and compare the effect of muscle relaxant in the group using the muscle relaxant and not using it in terms of the incidence and severity of postoperative sore throat and hoarseness.

Official Title
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Effect of Intraoperative Neuromuscular Blockade on Postoperative Sore Throat and Hoarseness in Patients Undergoing Spinal Surgery

Conditions
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Sore Throat

Intervention / Treatment
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* Drug: Rocuronium


Participation Criteria
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Eligibility Criteria
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Inclusion criteria patients scheduled to undergo elective lumbar spinal surgery Exclusion criteria known or predicted difficult airway neuromuscular diseases hepatic or renal dysfunction diseases or anatomical abnormalities in the neck, larynx, or pharynx requirement for postoperative mechanical ventilation

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group with muscle relaxant<br>Rocuronium is used during the operation to maintain moderate relaxation. | Drug: Rocuronium<br>* In the group to need the eletrophysiological monitoring during the operation, we don't inject muscle relaxant except anestheitic induction.<br>|
| Group without muscle relaxant<br>Rocuronium is not used during the operation for the eletrophysiological monitoring. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall cumulative incidence of postoperative sore throat | The incidence sore throat is assessed by the presence of sore throat | Within 24 hr evaluation period after operation | 
| Overall cumulative incidence of postoperative hoarseness | The incidence sore throat is assessed by the degree of hoarseness | Within 24 hr evaluation period after operation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of postoperative sore throat | The incidence of sore throat is assessed by the presence of sore throat. | At 1,6, and 24 hr after operation | 
| Severity of postoperative sore throat | A 0-100 mm NRS is used to evaluate the severity of sore throat (0, no pain; 100, worst pain imaginable). | At 1,6, and 24 hr after operation | 
| Incidence and severity of postoperative hoarseness | Hoarseness is defined as a voice quality different from the preoperative voice and graded as follows: none (no hoarseness), mild (recognized by the patient), moderate (obvious to the investigator), and severe (aphonia). | At 1,6, and 24 hr after operation | 
| Post operative analgesic consumption | the amount of patient-controlled analgesia and other analgesic medication consumed | within 24 hrs after operation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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muscle relaxant