Obstructive Sleep Apnea Syndrome In Patients Treated For Cancer Of The Upper Aerodigestive Tract

Study Overview
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Brief Summary
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Prospective open-label, non-randomized, monocentric, cohort study, to assess the prevalence and severity of sleep apnea syndrome in patients treated for cancer of the upper aerodigestive tract. The patient follows a usual course of care including, at the end of the treatment of his cancer of the upper aerodigestive tract, screening for obstructive sleep apnea syndrome at 3 months and 6 months (Epworth score and ventilatory polygraphy)

Detailed Description
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Prospective open-label, non-randomized, monocentric, cohort study, to assess the prevalence and severity of sleep apnea syndrome in patients treated for cancer of the upper aerodigestive tract. Patients are included in the study when they are hospitalized for panendoscopy. Thereafter, it takes about 1 month to start any treatment. The duration of treatment is estimated at about 5 months (the longest regimen would be induction chemotherapy followed by surgery and adjuvant complementary treatment). After which the patient follows a usual course of care including, at the end of the treatment of his cancer of the upper aerodigestive tract, screening for obstructive sleep apnea syndrome at 3 months and 6 months (Epworth score and ventilatory polygraphy).

Official Title
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Obstructive Sleep Apnea Syndrome In Patients Treated For Cancer Of The Upper Aerodigestive Tract : The SAOS-K Study

Conditions
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Upper Aerodigestive Tract Neoplasms, Obstructive Sleep Apnea-hypopnea Syndrome

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: macroscopic lesion suggestive of a cancerous tumour of the upper aerodigestive tract (oral cavity, oropharynx, larynx, hypopharynx, cavum, cervical lymph node metastases with an occult primary cancer) awaiting anatomopathological confirmation Exclusion Criteria: history of cancer of the upper aerodigestive tract history of known obstructive sleep apnea syndrome cancer of the thyroid, salivary glands, nose and paranasal sinuses patients under guardianship or curatorship

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Occurence of obstructive sleep apnea syndrome | Obstructive sleep apnea syndrome is defined by an apnea-hypopnea index greater than or equal to 15 per hour | 3 months after the end of treatment for cancer of the upper aerodigestive tract | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Delay in onset of obstructive sleep apnea syndrome after completion of cancer treatment | Delay in onset of obstructive sleep apnea syndrome after completion of cancer treatment | during the 6 months follow-up | 
| Epworth score | The Epworth auto-questionnaire, rated from 0 (better) to 24 (worse), assess day-time sleapiness. | at 3 months and 6 months | 
| Occurence of obstructive sleep apnea syndrome | Obstructive sleep apnea syndrome is defined by an apnea-hypopnea index greater than or equal to 15 per hour | 6 months after the end of treatment for cancer of the upper aerodigestive tract | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Upper Aerodigestive Tract Neoplasms, Obstructive Sleep Apnea-hypopnea Syndrome, Epworth score, Ventilatory Polygraphy