P. Gingivalis IgG Titer Test for Periodontitis

Study Overview
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Brief Summary
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This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens.

Detailed Description
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Background: Periodontitis is a prevalent silent infectious disease worldwide, and affects lifestyle-related diseases such as diabetes. Therefore, efficient screening of patients is essential for general health. This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens. Methods: Oral examination was performed and blood IgG antibody titers against periodontal pathogens were measured by ELISA, in 1387 subjects. The cut-off value of IgG titer was determined in receiver operating characteristic curve analysis, and changes in periodontal clinical parameters and IgG titers by periodontal treatment were evaluated. The relationships between IgG titers and severity of periodontitis were analyzed.

Official Title
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Assessment of Use of Plasma or Serum IgG Test to Screen for Periodontitis

Conditions
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Periodontitis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: periodontal patients adults Exclusion Criteria: difficulty of communication received periodontal therapy within 3 months with other diseases, i.e., hypertension, diabetes (self reported)

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| periodontitis<br>those with periodontitis and those without periodontitis | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Level of IgG antibodies in serum/plasma against periodontal pathogens | Serum/plasma samples will be screened for the presence of IgG antibodies against the below mentioned periodontal pathogens, using the ELISA method. Aggregatibacter actinomycetemcomitans, Eikenella corrodens, Prevotella intermedius, Porphyromonas gingivalis | 1 to 3 months after basic periodontal treatment (Scaling and root planing) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Periodontal pocket depth | Clinical observation on periodontal pocket depth before and after basic periodontal treatment, in order to confirm appropriate effects of the treatment. | 1 to 3 months after basic periodontal treatment | 
| Bleeding on probing | Judging from bleeding from gingiva after periodontal pocket probing, degree of inflammation will be understood. | 1 to 3 monthsafter basic periodontal treatment | 
| Tooth mobility | Clinical observation to understand decrease of inflammation | 1 to 3 months after basic periodontal treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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IgG titer, periodontopathic bacteria