Multicomponent Exercise Training in Frail Elderly

Study Overview
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Brief Summary
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The aim of the present study will be to assess the effectiveness of the multicomponent exercise training in frail for the physical function, frailty and performance. All the individuals will be assessed two times.

Detailed Description
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This will be a experimental, randomized controlled intervention study in frail. Subjects will be recruited at the Albertia Care Center, Madrid. The exercise training group will developed a concurrent training 3 days per week during 6 weeks. The control group will follow an usual care also for 6 weeks. The main variables will be as follows: Ultrasound imaging measurements for the lower limb: core muscles, vastus medialis, rectus femoris, vastus intermedius, gastrocnemius, soleus. We will employed a General Electric (GE) Ultrasound device in B mode to assess the thickness of the muscles. Heart rate variability with a Suunto smart bell. Activities of daily living with the Bartel index. Force-velocity profile and muscle power. Frailty with the Linda´s frailty criteria. The exercise program was applied for 6 weeks. A total of 18 sessions were distributed in 3 weekly sessions. The participants performed a resistance exercises: leg press at an intensity of 40%-60% with 10 repetitions, 12 repetitions of steps with their bodyweight and a plantar flexion followed by a cardiovascular high intensity interval training (HIIT) exercise walking on a treadmill. One measurements will be taken (pre), the second (post) measurements will be performed at 6 weeks.

Official Title
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Effectiveness of the Multicomponent Exercise Training in Frail Elderly

Conditions
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Frailty, Exercise Addiction

Intervention / Treatment
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* Other: Exercise training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men and women aged 75 years or more, 2 or more points in the Short Physical Performance Battery (SPPB) Capability of walking (alone or assisted) Exclusion Criteria: Severity cognitive alterations Severe disability on the Barthel score Surgeries in the previous 6 months Other any disorder that exclude for the exercise group.

Ages Eligible for Study
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Minimum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Exercise program<br>The exercise program was applied for 6 weeks. A total of 18 sessions were distributed in 3 weekly sessions. The participants performed a resistance exercises: leg press at an intensity of 40%-60% with 10 repetitions, 12 repetitions of steps with their bodyweight and a plantar flexion followed by a cardiovascular HIIT exercise walking on a treadmill. | Other: Exercise training<br>* A multicomponent exercise program<br>|
| Active Comparator: Daily activities<br>The patients who belongs to this group will continue to perform their daily routines. | Other: Exercise training<br>* A multicomponent exercise program<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Thickness of the core and quadriceps muscles | Thickness assessment by ultrasound imaging | Change from baseline muscle thickness at 6 weeks | 
| Heart rate variability | Heart rate variability by Suunto smart bell device | Change from baseline heart rate variability at 6 weeks | 
| Daily life activities | Bartel index questionnaire | Change from baseline daily life activities at 6 weeks | 
| Muscle power | Force-velocity profile for the lower limb muscle power | Change from baseline muscle power at 6 weeks | 
| Frailty | Frailty with the Linda´s frailty criteria | Change from baseline frailty at 6 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Frailty, Exercise, Aging