Clinical Application of Quantitative Ultrasonographic Analysis in Early Kidney Injury

Study Overview
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Brief Summary
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The purpose of this study was to quantify overall blood flow and renal cortical perfusion in patients with septic acute kidney injury (AKI) using ultrasound (US) Doppler and contrast-enhanced ultrasound (CEUS).

Detailed Description
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Kidney ultrasound is the most widely used imaging modality in initial AKI workup as it is widely available and free of complications. It is clinically feasible to use US Doppler and contrast-enhanced US (CEUS) to detect macroscopic and microscopic changes in renal blood flow, and also cardiac output alterations.The aim was to analyze changes in US Doppler and CEUS quantitative parameters in patients with septic AKI to explore perfusion within the renal parenchyma, and also measure global renal blood flow and cardiac output.

Official Title
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The Clinical Application of Ultrasound for Acute Kidney Injury During Sepsis - From Macroscopic to Microscopic Renal Perfusion Perspectives

Conditions
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Patient Admitted to Hospital With Acute Kidney Injury Due to Sepsis

Intervention / Treatment
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* Diagnostic Test: Ultrasound contrast agent (Sonovue)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Meets the AKI diagnostic criteria of the Kidney Disease: Improving Global Outcomes (KDIGO) Meets Sepsis 3.0 diagnostic criteria for sepsis: infection + SOFA ≥ 2 Exclusion Criteria: Urinary tract obstruction, hydronephrosis, etc. Left ventricular ejection fraction <30% (measured by transthoracic echocardiography), systolic pulmonary artery pressure >90 mmHg (measured by transthoracic echocardiography) Allergy or adverse reaction to contrast media

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Ultrasound contrast agent (Sonovue)|Patients are diagnosed by intravenous injection of ultrasound contrast on the first day of admission and information is collected by diagnostic ultrasound instruments|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ultrasound Doppler parameters | Time-averaged velocity (TAV)in cm/s | First 24 hours after admission | 
| Ultrasound Doppler parameters | Relative blood flow（RBF）in L/min | First 24 hours after admission | 
| Ultrasonography parameters | Time to peak (TTP)in senconds | First 24 hours after admission | 
| Ultrasonography parameters | Maximum intensity (Imax)in a.u（Acoustic intensity units） | First 24 hours after admission | 
| Ultrasonography parameters | area under curve is the multiplication of acoustic intensity and time（a.u*s） | First 24 hours after admission | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Acute kidney injury, contrast-enhanced ultrasound, renal perfusion, microcirculation