Iron Status in Women of Reproductive Age Reproductive Age

Study Overview
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Brief Summary
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Analyzed iron status, HFE mutations and ethnicity for women in five primary care centers in the United States and Canada using de-identified data from the HEIRS study.

Detailed Description
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HEIRS included a cross-sectional screening study of 101,168 patients, 25 years of age or older, in the primary care setting. Participants were recruited from four centers in the U.S .and one in Canada from February 2001 to February 2003. We will evaluate results for women aged 25-44 years of age who are self-reported as Asian, Black, Hispanic or White. The lower detection limit for the serum ferritin (SF) assay in the HEIRS study was 15 μg/L and therefore the definition of iron deficiency will be SF concentration ≤ 15 μg/L. Elevated SF concentrations, possibly indicative of elevated iron stores, will be classified by two definitions: 1) SF concentration > 300 μg/L and 2) SF >200 μg/L in combination with TSAT >45%. Proportions will be compared by Pearson's chi-square. Logistic regression models will be used to identify independent associations with measures of iron deficiency and elevated iron stores.

Official Title
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Ethnic and Genetic Factors of Iron Status in Women of Reproductive Age

Conditions
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Iron Metabolism Disorders

Intervention / Treatment
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* Other: observation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: primary care women included in the HEIRS study with in the age range of this study Self designation as Asian American, African American, Hispanic American or White. Exclusion Criteria: Age >44 years Self-described ethnicity other in than inclusion criterion 2.

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 44 Years

Sexes Eligible for Study
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Female

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Asian American non-pregnant<br>Women 25 to 44 years of age recruited in a primary care setting and self reported as Asian American and non-pregnant/non-breastfeeding. | Other: observation<br>* observation<br>|
| African American non-pregnant<br>Women 25 to 44 years of age recruited in a primary care setting and self reported as African American and non-pregnant/non-breastfeeding. | Other: observation<br>* observation<br>|
| Hispanic American non-pregnant<br>Women 25 to 44 years of age recruited in a primary care setting and self reported as Hispanic American and non-pregnant/non-breastfeeding. | Other: observation<br>* observation<br>|
| White non-pregnant<br>Women 25 to 44 years of age recruited in a primary care setting and self reported as white and non-pregnant/non-breastfeeding. | Other: observation<br>* observation<br>|
| Asian American pregnant<br>Women 25 to 44 years of age recruited in a primary care setting and self reported as Asian American and pregnant or breastfeeding. | Other: observation<br>* observation<br>|
| African American pregnant<br>Women 25 to 44 years of age recruited in a primary care setting and self reported as African American and pregnant or breastfeeding. | Other: observation<br>* observation<br>|
| Hispanic American pregnant<br>Women 25 to 44 years of age recruited in a primary care setting and self reported as Hispanic American and pregnant or breastfeeding. | Other: observation<br>* observation<br>|
| White pregnant<br>Women 25 to 44 years of age recruited in a primary care setting and self reported as White and pregnant or breastfeeding. | Other: observation<br>* observation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Elevated serum ferritin | Serum ferritin >300 ug/L | One measurement was made at the time of recruitment and this is the measurement that will be analyzed. | 
| Elevated serum ferritin and transferrin saturation | Serum ferritin >200 ug/L and transferrin saturation >45% | One measurement was made at the time of recruitment and this is the measurement that will be analyzed. | 
| Iron deficiency | Serum ferritin <15ug/L | One measurement was made at the time of recruitment and this is the measurement that will be analyzed. |