linjc16/ctgov huggingface dataset:
Cardiovascular Risk Evaluation and Antiretrovirals in HIV

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to determine the main factors contributing to predicted 10 year cardiovascular risk in an HIV infected cohort, and the role of anti-HIV drug use in altering this risk

Official Title
-----------------
Predicted 10-year Coronary Heart Disease Risk in HIV and Implications for Clinical Management: the CREATE Study

Conditions
-----------------
Cardiovascular Risk, HIV Infections

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Serologically proven HIV infection Attending general HIV outpatient clinic Exclusion Criteria: Attending a specialist outpatient clinic which might lead to recruitment bias

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| unselected HIV outpatient attendees<br>All HIV patients attending for general HIV care at 2 London Hospitals | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 10 year predicted cardiovascular risk |  | AT time of clinic attendence | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| coronary heart disease risk |  | at time of clinic attendence | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
HIV, Cardiovascular, Coronary hear disease, HAART, antiretroviral
Visual Stimulus Competition

Study Overview
=================
Brief Summary
-----------------
In this study, we will use behavioral methods to investigate several types of interactions that occur when visual stimuli conflict, such as when objects are presented nearby to each other, or to separate eyes. We will target purely sensory aspects by using simple geometric shapes: letters and lines. Our outcome measure will be performance thresholds.

Detailed Description
-----------------
Participants will be shown visual stimuli on displays and be asked to identify some aspect of the stimuli: their orientation and/or color, the existence of binocular suppression, etc. In different blocks, stimuli will be manipulated in different ways to characterize basic aspects of visual processing. For example, the contrast, color, and/or spatial layout of stimuli will be varied.

Official Title
-----------------
Visual Stimulus Competition

Conditions
-----------------
Visual Pathway Disorder

Intervention / Treatment
-----------------
* Behavioral: Item spacing


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Normal Vision English language Exclusion Criteria: Less than 20/20 in either eye Vision-affecting abnormalities (amblyopia, keratoconus, etc.) Ortho-K lenses
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Single Arm<br> | Behavioral: Item spacing<br>* Spatial proximity of items to one another<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Detection probability | Ability to detect a target stimulus as a function of flanker proximity | 2 hours |
Detection of Left Atrial Appendage (LAA) Thrombus: Comparison of Cardiac Magnetic Resonance Imaging and Transesophageal Echocardiogram

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to compare Cardiac Magnetic Resonance (CMR) Imaging with transesophageal echocardiography (TEE) in detecting the presence of LAA thrombi in men and women with atrial fibrillation presenting for cardioversion.

Detailed Description
-----------------
The identification of left atrial appendage (LAA) thrombus prior to cardioversion for patients with atrial fibrillation is crucial. LAA thrombus can be a frequent cause of cerebral stroke or peripheral embolism post cardioversion, and anticoagulation therapy is required in these instances to prevent cerebral events and avoid embolization. To date, TEE has been considered the clinical reference in detection of LAA thrombi with high diagnostic accuracy. However, diagnosis and size estimation of LAA thrombi remains challenging due to the complex anatomy of the LAA, and transesophageal echocardiography (TEE) is considered a semi-invasive procedure. To date, there have been few comparative studies involving TEE and cardiac magnetic resonance (CMR) imaging, and the results have been conflicting. With newer CMR Imaging techniques now available, we hypothesize that comparable results will be achieved in detecting LAA thrombus in subjects using a less invasive procedure.

Official Title
-----------------
Detection of Left Atrial Appendage Thrombus in Patients Referred For Cardioversion: Comparative Analysis of Cardiac Magnetic Resonance Imaging and Transesophageal Echocardiogram

Conditions
-----------------
Left Atrial Appendage Thrombi

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: atrial fibrillation Exclusion Criteria: ICDs pacemakers intracranial clips intracranial stimulator devices insulin pumps intra ocular metal foreign bodies cochlear implants LAA amputation as part of CABG and/or valve surgery GFR < 60 mL/min
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1/Cases<br>Subjects whom had cardioversion aborted due to LAA thrombus or suspicion of LAA thrombus on TEE. | |
| 2/Controls<br>Subjects with underlying atrial fibrillation undergoing elective TEE as clinically indicated for any reason. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Accuracy values for CMR Imaging for detection of LAA thrombus. (sensitivity, specificity, negative predictive value, and positive predictive value) |  | 24 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
left atrial appendage thrombi, transesophageal echocardiogram, cardiac magnetic resonance imaging, atrial fibrillation, cardioversion
Second-trimester TOP : a Retrospective Study Comparing Complications at 12-14 vs 14-16 Weeks of Gestation

Study Overview
=================
Brief Summary
-----------------
In France, the recently adopted law relating to the legal time limit for access to voluntary interruption of pregnancy has set a threshold of the term at which it can be performed up to 16 weeks of gestation. This single-centre study conduced at the Nancy Maternity Hospital is based on a retrospective cohort of all patients who underwent a medical termination of pregnancy between January 2010 and October 2021. The main objective is to evaluate the complications according to the term of the termination of pregnancy between two groups : [12-14] vs [14-16] weeks of gestation. The secondary objective is the distribution of these complications between the two groups. Pregnancy termination can be performed in two methods, either by medical method with mifepristone and misoprostol, or by surgical method by dilation and evacuation. Complications identified are haemorrhage, infection, retained product of trophoblast, uterine rupture and abortion induction failure. The hypothesis is the concomitant increase in complications with the term of the termination of pregnancy.

Official Title
-----------------
Second-trimester Termination of Pregnancy: A Retrospective Study Comparing Complications Related to Termination of Pregnancy at 12-14 Weeks' Gestation Versus 14-16 Weeks' Gestation

Conditions
-----------------
Abortion in First Trimester, Abortion, Second Trimester

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: termination of pregnancy for a medical reason between 12 and 16 weeks of gestation singleton pregnancy Exclusion Criteria: multiple pregnancy abortion occurred before the induction of termination of pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Termination of pregnancy between 12-14 weeks of gestation<br> | |
| Termination of pregnancy between 14-16 weeks of gestation<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| complications | hemorrhage, infection, retained product of conception, failure, uterine rupture | Day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| repartition of all complications | repartition of all complications between groups | Day 0 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
complications
The Use of Magnesium to Improve Blood Pressure, Cholesterol, and Glucose Control

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine if magnesium can improve blood pressure, cholesterol, and blood sugar control in patients with implantable cardioverter defibrillators (ICDs).

Detailed Description
-----------------
Magnesium is the second most abundant intracellular cation and plays a vital role in many physiologic processes. It has been determined that patients with cardiovascular disease have intracellular magnesium (Mgi) deficiencies. Among the ICD registries in Europe and the United States 64% and 77% of patients also carry the diagnosis of CAD, respectively. Patients with CAD have risk factors that lead to the development and or propagation of atherosclerosis. Paramount among these risk factors are hypertension, dyslipidemia, and diabetes. Comparison: Magnesium compared to placebo in patients with ICDs to evaluate the effect they have on cholesterol, blood pressure, and blood glucose.

Official Title
-----------------
The Use of Magnesium to Improve Hemodynamics, Cholesterol, and Glucose Control: A Substudy of AdMag

Conditions
-----------------
Hypertension, Dyslipidemia, Coronary Artery Disease, Diabetes

Intervention / Treatment
-----------------
* Drug: magnesium L-lactate


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Newly implanted ICD or recent ICD shock (within 6 months) Exclusion Criteria: Inability to swallow A non-cardiac disease with a survival prognosis of less than 12 months Hypermagnesemia Creatinine clearance less than 30mL/min Lactic acidosis or systemic acidosis syndrome Previous intolerance to magnesium L-lactate

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: magnesium L-lactate|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood pressure, cardiac output, systemic vascular resistance, thoracic fluid content, total cholesterol, low density lipoprotein, high density lipoprotein, triglycerides, and blood glucose |  | at baseline, 3, and 6 months of follow-up | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hemodynamics, Hypertension, Dyslipidemia, Diabetes, Implantable Cardioverter Defibrillator, Blood Pressure
Intervention to Improve Self-Care of Symptoms in Breast Cancer Survivors on Adjuvant Endocrine Therapy

Study Overview
=================
Brief Summary
-----------------
Hormone responsive breast cancer is common and costly. Long-term adjuvant endocrine therapy (AET) improves breast cancer outcomes greatly, but, unfortunately, is commonly associated with physical and emotional concerns. I propose to evaluate the feasibility and preliminary effectiveness of a behavioral intervention to facilitate problem identification, provide education, coaching for breast cancer survivors with symptoms while on AET. Therefore, the intervention intends to empower women to engage in better self-care and seek out resources they need, which, in turn, will lead to better symptom management.

Official Title
-----------------
Intervention to Improve Self-Care of Symptoms in Breast Cancer Survivors on Adjuvant Endocrine Therapy.

Conditions
-----------------
Breast Cancer Female

Intervention / Treatment
-----------------
* Behavioral: Behavioral Intervention.
* Other: Nutritional Education.


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age ≥ 50. Nonmetastatic bread cancer survivors reporting being bothered by 1 or more symptoms related to their treatment with AET (for > 0 months and < 6 months). Possess a household or cell telephone. Ability to provide informed consent. Exclusion Criteria: Clinically significant cognitive impairment. Communication barrier limiting ability to participate in telephone assessments.

Ages Eligible for Study
-----------------
Minimum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Control.<br>Nutritional Education. | Other: Nutritional Education.<br> <br> |
| Other: Behavioral Intervention<br>Behavioral Intervention. | Behavioral: Behavioral Intervention.<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Satisfaction determined by the Client Satisfaction Survey |  | Up to 6 months. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Breast Cancer., Adjuvant Endocrine therapy.
GENSARC 2008 : Medical Economic Evaluation of the Molecular Detection by FISH (Fluorescent in Situ Hybridization) and by PCR (Polymerase Chain Reaction) of Sarcomas Specific Translocations and Amplifications .

Study Overview
=================
Brief Summary
-----------------
The clinical and histological diagnosis of sarcomas is often very difficult. The identification of chromosomal and molecular anomalies, such as amplifications, deletions or fusion genes is a powerful help for establishing a correct diagnosis of sarcomas and their benign counterparts. However, the cost of the cytogenetic and molecular techniques for the detection of these alterations is often a limitation to their use. The aim of our study is to evaluate the direct cost of the molecular techniques in comparison to the cost that would be generated by an appropriate therapy and care management of the patient in case of an erroneous diagnosis.

Official Title
-----------------
GENSARC 2008 : Medical Economic Evaluation of the Molecular Detection by FISH (Fluorescent in Situ Hybridization) and by PCR (Polymerase Chain Reaction) of Sarcomas Specific Translocations and Amplifications .

Conditions
-----------------
Sarcoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with biopsy or excision of sarcoma (suspected or diagnosed) sampling reviewed by pathologists frozen sampling clinical data available Exclusion Criteria: opposition of patient
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sarcoma<br>patients with biopsy or excision of sarcoma (suspected or diagnosed) | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
economic evaluation, diagnostics, sarcoma
Consumer Engagement to Increase Advance Care Planning: Patient Randomization

Study Overview
=================
Brief Summary
-----------------
This is a study of the effect of consumer-directed financial incentives on completion of advance care planning among Medi-Cal patients.

Detailed Description
-----------------
Older adults receiving primary care from one of three clinics contracting with Partnership HealthPlan of California, a multi-county Medi-Cal managed care plan will be mass randomized to receiving educational materials regarding advance care planning with or without a financial reward for completing advance care planning.

Official Title
-----------------
Consumer-directed Financial Incentives to Increase Advance Care Planning Among Medi-Cal Patients

Conditions
-----------------
Advance Care Planning

Intervention / Treatment
-----------------
* Behavioral: Financial incentive
* Behavioral: Educational website


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Partnership HealthPlan of California enrollee Receipt of primary care from one of 3 participating clinics (Ole, Petaluma, West County) Age > 65 Exclusion Criteria: > 75

Ages Eligible for Study
-----------------
Minimum Age: 65 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: PREPARE<br>Access to Prepare for Your Care website and written encouragement to discuss ACP with one's PCP. | Behavioral: Educational website<br>* Research-verson of the Prepare for your care website (www.prepareforyourcare.org)<br>|
| Experimental: PREPARE+financial incentive<br>Access to Prepare for Your Care website and written encouragement to discuss ACP with one's PCP; offer of $50 to complete the website and entry into $1000 lottery for discussing ACP with one's PCP. | Behavioral: Financial incentive<br>* Offer of money designed to overcome barriers to advance care planning.<br>Behavioral: Educational website<br>* Research-verson of the Prepare for your care website (www.prepareforyourcare.org)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Having an advance care planning conversation with one's primary care provider | Primary care providers' documentation of an advance care planning conversation in the chart and/or via a Partnership HealthPlan of California ACP attestation form. | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Completion of Prepare for Your Care website modules | Logging into the website, completing the modules, and creating an action plan | 3 months |
Hypothermia in Cesarean Sectio Patients in Regional Anaesthesia

Study Overview
=================
Brief Summary
-----------------
To study the core temperature perioperatively in patients due for elective cesarean sectio in spinal anaesthesia. Core temperature will be registered by a zero-flux (SpotOn. 3m) probe on the forehead, starting in the holding area and continued until normotemperature post-operatively.

Official Title
-----------------
Hypothermia in Cesarean Sectio Patients in Regional Anaesthesia

Conditions
-----------------
Cesarean Section

Intervention / Treatment
-----------------
* Device: zero flux skin termometer


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Elective patients planned spinal anaesthesia Exclusion Criteria: Conversion of procedure to general anaesthesia allergy to temperature probe (adhesive)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: zero flux skin termometer|Core temperature is monitored continously, non-invasively|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| incidence of perioperative hypothermia, less than 36.0 degrees | mesured by zero flux in forehead | perioperatively | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| patient satisfaction: Patient will be asked to grade | Patient will be asked to grade their feeling of being Cold/warm | perioperatively, repeated | 
| duration of perioperative hypothermia | number of minutes below 36.0 degrees | perioperatively, continously | 
| shivering | any shivering due to being cold | perioperatively |
Body Composition in Infants and Children

Study Overview
=================
Brief Summary
-----------------
This study will test a new method for measuring body fat and muscle in infants and children: QMR.

Official Title
-----------------
Validation of a Body Composition Method for Infants and Children

Conditions
-----------------
Healthy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy child weighing between 0 and 110 pounds Exclusion Criteria: child has condition that may affect growth or bone development child has chronic disease child has disorder of carbohydrate metabolism child takes medication that could affect bone density child has any type of nonremovable metal
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body Composition |  | one-time visit | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
healthy children