Developing Non-Communicable Disease Registries in Africa : A Step Towards Providing Quality Data for Improving Patient Outcomes

Study Overview
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Brief Summary
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This umbrella protocol seeks to develop robust data registries for non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) with the aim of providing accurate and comprehensive data for the evaluation of such diseases in sub-Saharan African countries.Healthy volunteers will be included in the study for comparison. Additionally, the investigators aim to describe the gut microbiome community diversity of a cohort of community dwelling Nigerians and compare with CRC patients in Nigerian and at MSK. We will collect stool for microbiome and metabolomic analysis from community dwelling persons in the catchment area of ARGO facilities in Nigeria while contemporaneously administering an extensive medical and environmental exposure questionnaire.

Official Title
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Developing Non-Communicable Disease Registries in Africa: A Step Towards Providing Quality Data for Improving Patient Outcomes

Conditions
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Non-Communicable Disease

Intervention / Treatment
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* Behavioral: Questionnaire forms
* Other: Bio-specimen samples


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18 and older. Suspected or confirmed diagnosis of a non-communicable disease. OR Healthy volunteers/no confirmed diagnosis for comparison. Exclusion Criteria: Participants unwilling to sign consent. Participants under the age of 18

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| healthy participants and participants diagnosed with NCDs<br>This protocol will entail prospective collection of data on healthy participants and participants diagnosed with NCDs managed at collaborating institutions in SSA. Information to be obtained includes socio-demographic data, risk factors, disease-specific data, investigation and treatment details, as well as findings during follow-up. Particular reference will be made to outcome measures such as local and distant recurrence, survival and mortality. Follow-up data will be updated during clinic visits and also via phone calls. | Behavioral: Questionnaire forms<br>* The questionnaires will include information such as socio-demographic data, risk factors, disease specific data, investigation and treatment details as well as findings during followup. Particular reference will be made to outcome measures such as local and distant recurrence, survival and mortality.<br>Other: Bio-specimen samples<br>* Samples can include tissue, blood, urine, saliva, hair and nail clipping.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| # of patients that develope non-communicable diseases in Africa |  | 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Patient Outcomes, 18-114