Evaluation of Brain Damage Due to Coronary Angioplasty in Percutaneous Intervention Patients

Study Overview
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Brief Summary
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This study examines the formation mechanism and patient-related factors of silent cerebral infarcts, whose importance has become increasingly recognized in patients undergoing percutaneous coronary intervention.

Detailed Description
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This study was produced from the assistant's thesis and was previously accepted as a poster at EuroPCR 2020. We recently completed the full-length article. This thesis study was supported by Ondokuzmayis University.

Official Title
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Assessment of Silent Brain Injury in Chronic Total Occlusion Patients With Percutaneous Coronary Intervention

Conditions
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Silent Stroke, Coronary Disease

Intervention / Treatment
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* Diagnostic Test: Blood serum Neuron-specific Enolase measurement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: CTO and Non-CTO patients undergoing percutaneous coronary intervention Exclusion Criteria: baseline NSE elevation acute coronary syndromes or cardiac surgery within 4 weeks patients with a cerebrovascular accident intracranial hemorrhage and head trauma central nervous system tumor degenerative central nervous system disorders and neuroendocrine tumors

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Chronic Total Occlusion<br>Chronic total occlusion patients undergoing percutaneous coronary intervention. | Diagnostic Test: Blood serum Neuron-specific Enolase measurement<br>* The Silent Brain Injury ratio was compared by measuring the Neuron-specific enzyme level with venous blood sampling from both patient groups before and after percutaneous coronary intervention.<br>|
| Non-Chronic Total Occlusion<br>Non-Chronic total occlusion patients undergoing percutaneous coronary intervention. | Diagnostic Test: Blood serum Neuron-specific Enolase measurement<br>* The Silent Brain Injury ratio was compared by measuring the Neuron-specific enzyme level with venous blood sampling from both patient groups before and after percutaneous coronary intervention.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Baseline Neuron-specific Enolase (NSE) measurement | Baseline NSE measurement to exclude non-PCI dependent brain injury. Elevation of >20 ng/ml was considered as silent brain injury. Patients with basal nse elevation were considered as SBI and excluded from the study. | NSE blood levels were measured 1-2 hours before the procedure. | 
| Silent Brain Injury diagnosis | NSE blood levels were measured 12-18 hours after the procedure. Elevation of >20 ng/ml was considered as SBI. | 12-18 hours after percutaneous coronary intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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silent brain injury, chronic total occlusion, percutaneous coronary intervention, Neuron specific enolase