Prognosis Analysis of Elderly Donor Liver in Liver Transplantation

Study Overview
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Brief Summary
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Based on the follow-up data of elderly donation after cardiac death(DCD) donor liver transplant recipients from the CLTR, a database and official website for national data gathering. patients who met the enrollment criteria were screened for postoperative complications and survival for statistical analysis to understand the prognosis of patients and analyze the risk factors affecting their prognosis.

Detailed Description
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Since the Chinese organ donation system was developed in 2015, donation has been the only source of organs for transplantation in China. Adult patients (age 18 or older) who underwent LT using grafts from deceased donors between January 1st, 2015, and December 31st, 2018, were retrospectively identified using the CLTR, a database and official website for national data gathering. Based on the follow-up data of elderly DCD donor liver transplant recipients from the CLTR, a database and official website for national data gathering. patients who met the enrollment criteria were screened for postoperative complications and survival for statistical analysis to understand the prognosis of patients and analyze the risk factors affecting their prognosis.

Official Title
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Prognosis Analysis of Elderly Donor Liver From Donation After Cardiac Death in Liver Transplantation: a Multicenter Clinical Study

Conditions
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Liver Transplantation, Hepatocellular Carcinoma, Survival

Intervention / Treatment
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* Other: Age


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Recipient age ≥ 18 years and < 65 years. Donor age ≥ 18 years. Exclusion Criteria: Recipient age <18 years or ≥65 years. Donor age <18 years. Patients who died within 30 days after transplantation. Secondary liver transplantation. Multiple organ transplantation. Patients with incomplete data or failed follow-up.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| OLDs<br>Older liver donors (OLDs) and recipients were defined as individuals whose donor age was equal to or greater than 60 years. Subjects matching the characteristics of this group were screened from the database according to inclusion and exclusion criteria, and preoperative and postoperative characteristics of the corresponding recipients and donors were collected and recorded for subsequent analysis. | Other: Age<br>* The study was retrospective and did not involve the application of interventions.<br>|
| ILDs<br>Ideal or young liver donors (ILDs) and recipients were defined as donors aged 18-40 years. Subjects matching the characteristics of this group were screened from the database according to inclusion and exclusion criteria, and preoperative and postoperative characteristics of the corresponding recipients and donors were collected and recorded for subsequent analysis. | Other: Age<br>* The study was retrospective and did not involve the application of interventions.<br>|
| ALDs<br>Average liver donors (ALDs) and recipients were defined as donor age 40-59 years. Subjects matching the characteristics of this group were screened from the database according to inclusion and exclusion criteria, and preoperative and postoperative characteristics of the corresponding recipients and donors were collected and recorded for subsequent analysis. | Other: Age<br>* The study was retrospective and did not involve the application of interventions.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Post-operative survival time | Postoperative survival time for patients receiving liver transplantation | Time from the end of liver transplantation to the patient's death, or the end of follow-up by December 31, 2020. whichever came first, assessed up to 72 months. | 
| Transplanted liver status | Postoperative Liver Function in Patients Undergoing Liver Transplantation | Time from the end of liver transplantation to the patient's death, or the end of follow-up by December 31, 2020. whichever came first, assessed up to 72 months.The functional status of the transplanted liver was recorded during this period. | 
| Recurrence of the primary disease after surgery | Recurrence of primary disease in patients who underwent liver transplantation after surgery | The time period between liver transplantation and the initial examination revealing a recurrence of primary disease, or until the end of follow-up on December 31, 2020.whichever came first, assessed up to 72 months. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Surgery details | Detailed information such as operation time | Intraoperative | 
| Post-operative complications in patients who underwent liver transplantation | Specific details of all post-operative complications in patients who underwent liver transplantation | Time from the end of liver transplantation to the patient's death, or the end of follow-up by December 31, 2020. whichever came first, assessed up to 72 months.During this period, all postoperative complications of the patient will be recorded. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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elderly donor, liver transplantation, donation after cardiac death, hepatocellular carcinoma, survival