Postprandial Response to Different Jams

Study Overview
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Brief Summary
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The aim of this study is to investigate the effects of an acute intake of three different types of strawberry jam, differing in the carbohydrates and antioxidants content, on postprandial glucose metabolism, lipid profile, antioxidant status and satiety indices, in healthy adults.

Detailed Description
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Study Design: Randomized, postprandial, crossover, double-blind intervention with three arms. Subjects: Sixteen healthy adults Product studied: At each arm, participants consume 60g of strawberry jam: High-sugar jam (traditional; HS), Low-sugar jam (without added-sugar; LS), Low-sugar jam including antioxidant extract from strawberry pulp (LSA).

Official Title
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Study of the Effects of Three Strawberry Jams, Differing in Carbohydrate and Antioxidant Content, on Postprandial Response in Healthy Subjects

Conditions
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Postprandial, Hyperglycemia, Postprandial, Feeding Behaviors, Antioxidant, Lipid Profile

Intervention / Treatment
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* Other: Strawberry Jam


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult men and women Normal weight or overweight (BMI between 18.5 and 29.9 kg/m2) Age between 20 and 50 years old. Exclusion Criteria: To suffer from any chronic disease related to metabolism, To follow concomitant medications, To follow slimming treatments or hormone replacement therapy, To have any inability to perform the follow-up, Smoking, Known food allergies, Pregnancy, lactation or menopause

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: High Sugar (HS)<br>Study of the postprandial effects after consuming 60g of strawberry jam with high sugar content | Other: Strawberry Jam<br> <br> |
| Experimental: Low Sugar (LS)<br>Study of the postprandial effects after consuming 60g of strawberry jam with low sugar content | Other: Strawberry Jam<br> <br> |
| Experimental: Low Sugar + Antioxidant (LSA)<br>Study of the postprandial effects after consuming 60g of strawberry jam with low sugar content and an antioxidant extract from strawberry pulp | Other: Strawberry Jam<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Plasma malondialdehyde (MDA) postprandial measure | Plasma MDA measured at baseline and each 30 minutes during 2 hours after consuming 60 g of the experimental jam | up to 120 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum glucose postprandial concentration | Serum Glucose measured at baseline and each 30 minutes during 2 hours after consuming 60 g of the experimental jam | Baseline, 30, 60, 90 and 120 minutes | 
| Serum insulin postprandial concentration | Serum insulin measured at baseline and each 30 minutes during 2 hours after consuming 60 g of the experimental jam | baseline, 30, 60, 90 and 120 minutes | 
| HOMA insulin resistance index | HOMA-IR calculated at baseline and each 30 minutes during 2 hours after consuming 60 g of the experimental jam | Baseline, 30, 60, 90 and 120 minutes | 
| Serum total cholesterol postprandial concentration | Serum total cholesterol measured at baseline and each 30 minutes during 2 hours after consuming 60 g of the experimental jam | Baseline, 30, 60, 90 and 120 minutes | 
| Serum HDL-cholesterol postprandial concentration | Serum HDL-cholesterol measured at baseline and each 30 minutes during 2 hours after consuming 60 g of the experimental jam | Baseline, 30, 60, 90 and 120 minutes | 
| Serum LDL-cholesterol postprandial concentration | Serum LDL-cholesterol calculated at baseline and each 30 minutes during 2 hours after consuming 60 g of the experimental jam | Baseline, 30, 60, 90 and 120 minutes | 
| Serum Uric Acid postprandial concentration | Serum Uric Acid measured at baseline and each 30 minutes during 2 hours after consuming 60 g of the experimental jam | Baseline, 30, 60, 90 and 120 minutes | 
| Plasma Glutathione Peroxidase postprandial activity | Plasma Glutathione Peroxidase activity measured at baseline and each 30 minutes during 2 hours after consuming 60 g of the experimental jam | Baseline, 30, 60, 90 and 120 minutes | 
| Postprandial Plasma Total Antioxidant Capacity | Plasma Total Antioxidant capacity measured at baseline and each 30 minutes during 2 hours after consuming 60 g of the experimental jam | Baseline, 30, 60, 90 and 120 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Antioxidant, glucose metabolism, jam, polyphenols, postprandial, strawberry