linjc16/ctgov huggingface dataset:
Influence of an Exercise for Trunk Stabilization Performed in Stable and Unstable Surfaces for Chronic Low Back Pain.

Study Overview
=================
Brief Summary
-----------------
Motor control exercises have demonstrated a good option for recovery from chronic low back pain. The purpose of this study is investigated the effectiveness of an exercise program for trunk stabilization performed in stable and unstable surfaces for people with nonspecific chronic low back pain (NCLBP). Patients will be randomly divided into 3 groups; control group will receive placebo treatment with shortwave; stable group will receive an exercise protocol to stabilize the trunk on a stable surface and unstable group will receive the same exercise protocol but performed on an unstable surface. We hypothesized the unstable group will present pain reduction and functional improvement.

Official Title
-----------------
Influence of an Exercise Program for Trunk Stabilization Performed in Stable and Unstable Surfaces for Chronic Low Back Pain: Single-blind, Randomized Controlled Clinical Trial.

Conditions
-----------------
Low Back Pain

Intervention / Treatment
-----------------
* Other: Placebo
* Other: Stable surface exercises
* Other: Unstable surface exercises


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Non-specific low back pain Sedentary Previous low back pain last 6 months Exclusion Criteria: Traumatic, inflammatory, infectious or tumours etiology Positive neurological findings (leg pain) Pregnancy Previous spine or lower limb surgery Contraindicated for short-waves aplication

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo<br>Shortwave 30 minutes. | Other: Placebo<br>* Shortwave<br>|
| Active Comparator: Stable<br>Stable surface exercises | Other: Stable surface exercises<br>* Stable surface exercises<br>|
| Experimental: Unstable<br>Unstable surface exercises | Other: Unstable surface exercises<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain Scores on the Visual Analog Scale |  | 4 weeks |
Prognostic Factors and Oncological Outcomes in Laparoscopic Liver Resection for CRLM

Study Overview
=================
Brief Summary
-----------------
Laparoscopic liver resection (LLR) has gained acceptance as an effective treatment for colorectal liver metastases (CRLM) in selected patients, providing similar oncologic outcomes compared to open liver resection (OLR). A single-center retrospective analysis of a prospectively maintained database was performed. The primary aim of this study was to determine prognostic factors for the survival outcomes associated with LLR for CRLM.

Detailed Description
-----------------
LLR was defined as pure LLR, including conversions to OLR. In case of missing data, additional details were retrieved from the individual patient file. Data on patient demographics, timing of diagnosis, neoadjuvant chemotherapy (NAC), tumor characteristics (both primary tumor and CRLM), histopathology, molecular characteristics, operative technique (including classification into anatomically major/technically major/minor LR), intra- and postoperative course, adjuvant chemotherapy (AC) as well as oncological outcomes (OS and DFS) were gathered and analyzed. Postoperative complications were graded according to the Clavien-Dindo classification. Complications were classified as major in case of Clavien-Dindo ≥ 3A.

Official Title
-----------------
Laparoscopic Liver Resection for Colorectal Liver Metastases: Retrospective Analysis of Prognostic Factors and Oncological Outcomes in a Single-center Cohort

Conditions
-----------------
Colorectal Cancer, Liver Metastases, Surgery

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients diagnosed with colorectal liver metastases Patients who received laparoscopic liver resection for colorectal liver metastases Patients who received the laparoscopic liver resection between September 2011 and mid-March 2020 Exclusion Criteria: Patients with contraindication for laparoscopic liver resection Refusal to participate in the study
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Survival outcomes | Overall and disease-free survival (Kaplan-Meier method) | 9 years | 
| Prognostic factors | Univariate Cox proportional-hazards regression analysis | 9 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
hepatopancreatobiliary, laparoscopic liver resection, colorectal liver metastasis
Assessment of Ovarian Reserve in Women With Rheumatologic Diseases

Study Overview
=================
Brief Summary
-----------------
Our infertility unit has started a clinic for women with rheumatological diseases. those women are prone to infertility problems and it might be due to their illness or cytotoxic treatment . In our study we are going to observe the effect of their disease on ovarian reserve. we will assess it by using intravaginal sonography and blood test such as hormonal profile and anti-mullerian hormone (AMH).

Official Title
-----------------
The Influence of Rheumatologic Diseases on Fertility and Ovarian Reserve

Conditions
-----------------
Rheumatologic Diseases, Ovarian Reserve, Infertility

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Rheumatologic disease Exclusion Criteria: none

Ages Eligible for Study
-----------------
Minimum Age: 12 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hormone profile | Assessment of ovarian function using hormone profile and AMH levels in serum, in women with rheumatologic disease. | 4 years | 
| antral follicular count | we will use sonography to assess the antral follicular count as a parameter for ovarian reserve in women with rheumatologic disease. | 4 years |
Acupuncture and Hypertension

Study Overview
=================
Brief Summary
-----------------
Although traditional Chinese medicine advocates the use of acupuncture not only to induce analgesia but also to treat essential hypertension, acupuncture's postulated antihypertensive efficacy in humans has not been subjected to rigorous Western scientific testing. Before advocating acupuncture as an effective complementary/alternative medicine strategy for essential hypertension, it is necessary to demonstrate that the beneficial effects of acupuncture are scientifically robust, long-lasting, and explicable in terms of modern scientific mechanisms. In spontaneously hypertensive rats, acupuncture-like electrical stimulation of thinly myelinated (Group III) somatic afferents activates central endorphin (naloxone-sensitive) pathways that elicit long-lasting decreases in sympathetic nerve activity (SNA) and blood pressure. The ability to record SNA with microelectrodes in conscious humans provides a new opportunity to test this novel mechanistic hypothesis in patients undergoing electroacupuncture, a modification of the ancient technique that provides a quantifiable and reproducible stimulus to human skeletal muscle afferents. Using a randomized, double-blind placebo-controlled design, we will test the following major hypotheses: Electroacupuncture produces a long-lasting reduction in SNA, thereby providing a safe and effective complementary treatment of human hypertension. Given the enormous interest in acupuncture by our lay public, but the paucity of Western scientific data about its efficacy in cardiovascular disorders, our studies in normotensive and hypertensive humans should provide a conceptual framework for deciding whether to accept or reject the large body of Chinese (and Russian) literature advocating acupuncture as a safe and effective treatment of essential hypertension and other cardiovascular disorders (such as heart failure, and myocardial ischemia).

Official Title
-----------------
Acupuncture and Hypertension-Efficacy and Mechanisms

Conditions
-----------------
Hypertension

Intervention / Treatment
-----------------
* Procedure: Acupuncture


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with normal blood pressures or blood pressures over 120/80 up to 165/105

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Acupuncture|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
A Pilot Study of Functional Optical Coherence Tomography for Ocular Imaging

Study Overview
=================
Brief Summary
-----------------
Growing evidence shows that altered blood flow plays a major role in many vision-threatening diseases including glaucoma, diabetic retinopathy, age-related macular degeneration, Central Retinal Vein Occlusion, and Branch Retinal Vein Occlusion. Optical coherence tomography, an established imaging technique use for eye exam in clinical ophthalmology, provides high-resolution cross sectional images of the retina and has increased our ability to understand many eye diseases.

Detailed Description
-----------------
Optical Coherence Tomography is a non-invasive technique use a broadband light source to illuminate the area of study with light in the near infrared spectrum, then obtains static images of tissue structure from interference signals of the back-reflected light. Optical Coherence Tomography a non-contact, non-invasive means of documenting both tissue structure and blood flow changes in ocular disease and can provide high resolution cross-sectional images of tissue structure, direct visualization of blood flow in blood vessels of the eye.

Official Title
-----------------
A Pilot Study of Functional Optical Coherence Tomography for Ocular Imaging

Conditions
-----------------
Glaucoma, Diabetic Retinopathy, Age-Related Macular Degeneration, Central Retinal Vein Occlusion, Branch Retinal Vein Occlusion

Intervention / Treatment
-----------------
* Device: Optical Coherence Tomography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult 18 years and older with normal eye, or has been diagnosed with eye disease. Exclusion Criteria: Less than 18 years of age.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Optical Coherence Tomography<br>Optical Coherence Tomography | Device: Optical Coherence Tomography<br>* Optical Coherence Tomography<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Medical exam tool | Optical Coherence Tomography imaging technique of the retina and ability to diagnose and manage many eye diseases | 24 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
eye exam, Retina
Direct Effect of Caffeine on Diaphragmatic Muscles

Study Overview
=================
Brief Summary
-----------------
The mechanism of methylxanthines is thought to increase chemoreceptor responsiveness to CO2 in central nervous system. Besides, effect of methylxanthines on diaphragmatic contractility has also been found in experimental studies. A study of premature newborns has showed caffeine increase diaphragmatic activity and tidal volume. But, there is limited data about caffeine direct effect on diaphragma. Objective: The investigators aimed to show the direct effect of caffeine on diphragmatic contractility. Method: The babies under 32 weeks with respiratory support, are being enrolled in this study if caffeine treatment is decided to receive. Evaluation of muscle contraction is being made by ultrasound before and 30 minutes after caffeine loading dose. Right and left sides of diaphragm thickness are being measured by two clinicians on B mode ultrasound by anterior subcostal view. The velocity before and after caffeine administration will be calculated, dividing excursion frequency (parameter) for inspiratory time. Movement of the diaphragm at inspiratory and expiratory phases are also observed on M mode and the difference between the two phases are measured.

Official Title
-----------------
Direct Effect of Caffeine on Diaphragmatic Muscles

Conditions
-----------------
Caffeine

Intervention / Treatment
-----------------
* Drug: Caffeine citrate


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: newborns under 32 weeks with respiratory support caffeine is decided to give Exclusion Criteria: babies with congenital malformations

Ages Eligible for Study
-----------------
Minimum Age: 1 Day
Maximum Age: 7 Days

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>newborns under 32 weeks with respiratory support if they are decided to start caffeine treatment | Drug: Caffeine citrate<br>* diaphragm contractility after administration<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| diphragmatic contractility | diphragmatic contractility measured by ultrasonographic evaluation | 30 minutes |
Effectiveness of School-based Health and Nutrition Education to Improve Health and Dietary Practices of Primary School Children From Jimma Zone

Study Overview
=================
Brief Summary
-----------------
School based Health and Nutrition Education (SHNE) is a key component of school health and nutrition programs that can address several health and nutrition issues in Ethiopia.

Conditions
-----------------
Behaviour

Intervention / Treatment
-----------------
* Behavioral: school based health and nutrition education


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Grade 5 to 8 Exclusion Criteria: Mental Problem Has no Family

Ages Eligible for Study
-----------------
Minimum Age: 12 Years
Maximum Age: 19 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: School-based health and nutrition education<br> | Behavioral: school based health and nutrition education<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effectiveness of school based health and nutrition education on on health, diet related behavior and food security |  | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| impacts of health and nutritional education on food hygiene and reproductive health |  | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Nutrition, Food, Security, School, Health
Regenerative Medicine in Ocular Surface: Application of Cell Therapy for Ocular Surface Repair Using Progenitor Cells of Sclerocorneal Limbus Amplified ex Vivo

Study Overview
=================
Brief Summary
-----------------
Progenitor limbo sclerocorneal cells have properties of proliferation and differentiation to corneal and conjunctival epithelium. This cells can be isolated and ex vivo expanded using cell culture technics that could permit the biological replacement of damaged ocular surface.

Official Title
-----------------
Regenerative Medicine in Ocular Surface: Application of Cell Therapy for Ocular Surface Repair Using Progenitor Autologous Cells of Sclerocorneal Limbus Amplified ex Vivo

Conditions
-----------------
Unilateral Limbic Insufficiency

Intervention / Treatment
-----------------
* Procedure: biological replacement corneal surface


Participation Criteria
=================
Eligibility Criteria
-----------------
principal Inclusion Criteria: Serious unilateral limbic insufficiency Normal ophthalmological clinical examination in the opposite eye (biopsied eye) Exclusion Criteria: one-eyed serious disorders in palpebral dynamics bilateral limbic insufficiency, immunological, systemic or local illness like toxical epidermic necrosis or pemphigoid breastfeeding or pregnancy positive serology of HIV, VLTH, HVC, HVB, CMV, Trypanosoma Cruzi or Treponema Pallidum

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Progenitor Autologous Cells<br>Progenitor Autologous Cells of Sclerocorneal Limbus Amplified ex Vivo | Procedure: biological replacement corneal surface<br>* the expanded tissue will be applied to patient to replace the damaged ocular surface<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual Acuity | visual acuity improvement | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improvement in appearance of ocular surface | presence of corneal epithelium de novo | 6 months | 
| lack of scar tissue in ocular surface |  | 6 months | 
| decrease of preexisting corneal vascularization |  | 6 months | 
| Improvement of corneal transparency |  | 6 months | 
| absence or decrease of corneal conjunctivalization | the amount of caliciform cells using impression cytology will be compare between screening and 6 months visit | 6 months | 
| adverse events |  | 6 months |
The Efficacy of Glucagon Like Peptide (GLP) - 1(7-36) Amide for Glycemic Control in Critically Ill Patients

Study Overview
=================
Brief Summary
-----------------
The goal of this present proposal is to examine the efficacy of GLP-1 administered to control blood glucose in critically ill patients.

Detailed Description
-----------------
All patients whom on admission to the ICU (surgical, burn, & cardiac) who are expected to receive intensive insulin therapy for at least 72 hours are eligible to be enrolled. Once enrolled, the patients will be randomized to one of two groups: the experimental (intravenous GLP-1 infusion for 72 hours) or control groups (intravenous 0.9% sodium chloride (NaCl) infusion for 72 hours) in a double masked fashion. While enrolled, all patients will receive standard-of-care insulin therapy. Both groups will be maintained on the standard ICU specific protocol for glucose control.

Official Title
-----------------
The Efficacy of GLP - 1 (7-36) Amide for Glycemic Control in Critically Ill Surgical Patients

Conditions
-----------------
Critically Ill, Hypoglycemia

Intervention / Treatment
-----------------
* Drug: Glucagon-Like Peptide-1
* Drug: Saline


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Men and women age > 21 to 75 years of age. All subjects who meet ICU specific criteria for inclusion in their glucose protocol and placed on insulin infusion protocol as standard of care. Able to obtain patient or proxy consent. Exclusion Criteria: Current diagnosis of malignancy. Type 1 diabetes. Inability to obtain informed consent. On any Phase 1 trial.

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: GLP-1<br> | Drug: Glucagon-Like Peptide-1<br>* 5ng/kg-1/min-1 GLP-1 infused in 3 ml continuously over 72 hours.<br>* Other names: GLP-1;|
| Placebo Comparator: Saline<br> | Drug: Saline<br>* 5ng/kg-1/min-1 placebo infused in 3 ml continuously over 72 hours.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To Compare the Composite Overall Amount of Insulin Used With GLP-1 vs. Placebo to Reach and Maintain the ICU-specific Target Glucose Range. |  | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Compare the Number of Hypoglycemic Events Between GLP-1/Placebo Treatment |  | 2 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Intensive insulin therapy (IIT), Insulin infusion, Tight glycemic control, Intensive Care Units