Intravenous Infusion of Lidocaine in Colonoscopy

Study Overview
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Brief Summary
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intravenous infusion of lidocaine significantly reduce fatigue and pain and improve the patients satisfaction after sedation for colonoscopy.

Detailed Description
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This study divide patients into two groups, lidocaine group one will be given lidocaine intravenously; control group will be given saline . the difference between patients fatigue and pain will be compared. and the propofol consumption, pain after infusion of propofol, patients, endoscopists and anaesthesist satifaction, the incidence of hypotenstion, hypoxia, and bradycardia will aslo be compared between the two groups.

Official Title
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Efficacy of Intravenous Infusion of Lidocaine in Sedation for Colonoscopy: a Randomised Placebo-controlled Study

Conditions
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Sedation

Intervention / Treatment
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* Drug: placebo
* Drug: lidocaine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Inclusion Criteria: patients aged >18 years who were scheduled for colonscopy at Qilu hospital. Exclusion Criteria:patients with ASA (American Society of Anesthesiologists) Class 4 or 5, pre-existing hypoxemia (SpO2 <90%), hypotension (systolic blood pressure <90 mm Hg), bradycardia (HR<50 beats/min), uncontrolled hypertension (SBP >170 mm Hg, diastolic blood pressure>100 mm Hg), severe renal or liver failure, pregnancy or lactation, allergy to lidocaine, atrioventricular block, epilepsy, and inability to give informed consen -

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Participants are randomly assigned to controll group or lidocaine group. Participants of control group are given placebo while participants of lidocaine group are given lidocaine.
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: control group<br>the control group will be given the same volume of saline as the experimental group | Drug: placebo<br>* the control group will be given the same volume of saline.<br>* Other names: saline;|
| Experimental: lidocaine group<br>the experimental group will be given l-1.5mg lidocaine and then 2mg/kg/h | Drug: lidocaine<br>* the experimental group will be given 1-1.5mg/kg lidocaine and then 2mg/kg/h<br>* Other names: Compound Lidocaine Hydrochloride Injiection;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| fatigue score after colonoscopy | fatigue were measured on a 0-10VAS at arrival in the recovery room ,30min later | half a year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pain socre after colonoscopy | pain were measured on a 0-10VAS at arrival in the recovery room ,30min later | half a year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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intravenous lidocaine coloscopy