Efficacy Study of Autosuggestion for Quality of Life of Geriatric Patients

Study Overview
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Brief Summary
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The objective is to analyze the efficacy of autosuggestion for geriatric patients's quality of life and its impact to psycho-neuro-endocrine-immune pathways. The primary outcome is quality of life. The hypothesis of this study is that autosuggestion will increase geriatric patient's quality of life based on its impact to psycho-neuro-endocrine-immune pathways.

Detailed Description
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Geriatric patients diagnosed with multipathology after getting information and signing informed consent will be included in this trial. Autosuggestion was created by patients according to their preferences, modified by researcher to accomplish autosuggestion principles, recorded in a tape to be heard by walkman daily for 30 days. Intervention and control groups received usual standard medical therapy. Baseline data were collected within one week after admission. Then the subject will be followed up for 30 days. Primary outcome was quality of life measured by COOP chart, analyze using on treatment analysis. Secondary outcomes were serum cortisol, interleukin-2, interleukin-6, IFN-ϒ (Interferon gamma), and N Acetyl Aspartat/ creatine ratio in limbic and paralimbic system by Magnetic Resonance Spectroscopy.

Official Title
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Quality of Life and Psycho-Neuro-Endocrine-Immunology Pathway of Geriatric Patients: A Trial of Autosuggestion

Conditions
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Quality of Life for Geriatric Patients.

Intervention / Treatment
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* Behavioral: Autosuggestion for 30 days


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age: ≥ 60 years old with multipathology, inpatients Not in steroid therapy Could communicate (Karnofsky score: 40% or Zubrod/WHO score: 3) Cooperative Willing to go through all of the research steps. Exclusion Criteria: Stroke Multiple Sclerosis Brain Tumour Using Pace maker

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Autosuggestion<br> | Behavioral: Autosuggestion for 30 days<br> <br> * Other names: Self talk;|
| No Intervention: Standard medical theraphy<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of Life | Measured by COOP chart | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum Cortisol (ng/mL) | Change from baseline in Serum Cortisol concentration (ng/mL) measured by Radioimmunoassay method at 08.00-09.00 am. | 30 days | 
| Interleukin-2 (pg/mL) | Change from baseline in Interleukin-2 concentration (pg/mL) measured by ELISA method at 08.00-09.00 am. | 30 days | 
| Interleukin-6 (pg/mL) | Change from baseline in Interleukin-6 concentration(pg/mL) measured by ELISA method at 08.00-09.00 am. | 30 days | 
| Interferon Gamma (pg/mL) | Change from baseline in Interferon Gamma concentration (pg/mL) measured by ELISA method at 08.00-09.00 am. | 30 days | 
| N Acetyl Aspartat/ creatine ratio in limbic and paralimbic system (amygdala, hippocampus, hypothalamus, temporal lobe, accumbens nuclei, prefrontal cortex) | Ratio change from baseline by Magnetic Resonance Spectroscopy. | 30 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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autosuggestion, quality of life, geriatric, serum cortisol, Interferon gamma, interleukin-2, interleukin-6, neuroplasticity