Effect of Different Protein Diets on Glucose and Insulin Metabolism and Substrate Partitioning

Study Overview
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Brief Summary
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The purpose of this study is to determine whether different protein diets affects glucose and insulin metabolism and substrate partitioning.

Official Title
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Effect of Different Protein Diets on Glucose and Insulin Metabolism and Substrate Partitioning

Conditions
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Insulin, Glucose Metabolism

Intervention / Treatment
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* Dietary Supplement: Control
* Dietary Supplement: High dairy protein
* Dietary Supplement: vegetable protein
* Dietary Supplement: High GI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: BMI: 18.5-25 kg/m2 (lean) Gender: Male Age: <35 years Caucasian Exclusion Criteria: Elevated fasting blood glucose level Lactose intolerant Diabetes Mellitus Hypertension (systolic/diastolic blood pressure) Hypotension (systolic/diastolic blood pressure) Cardiovascular diseases Asthma and other obstructive pulmonary diseases

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Control<br>Diet consists of 15% dairy protein and low Glycemic Index (GI < 40), 55 En% carbohydrates and 30 En% fat | Dietary Supplement: Control<br>* Diet consists of 15 En% dairy protein and low GI, 55 En% carbohydrates and 30 En% fat<br>|
| Experimental: High dairy protein<br>Diet consists of 25% dairy protein and low GI (GI < 40), 45 En% carbohydrates and 30 En% fat | Dietary Supplement: High dairy protein<br>* Diet consists of 25 En% dairy protein and low GI, 55 En% carbohydrates and 30 En% fat<br>|
| Experimental: vegetable protein<br>Diet consists of 15 En% vegetable protein and low GI (GI < 40), 55 En% carbohydrates and 30 En% fat | Dietary Supplement: vegetable protein<br>* Diet consists of 15 En% vegetable protein and low GI, 55 En% carbohydrates and 30 En% fat<br>|
| Experimental: High GI<br>Diet consists of 15 En% dairy protein and high GI(GI > 60, 55 En% carbohydrates and 30 En% fat | Dietary Supplement: High GI<br>* Diet consists of 15 En% dairy protein and high GI, 55 En% carbohydrates and 30 En% fat<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glucose and insulin metabolism (24 h) |  | 24 h | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Substrate partitioning and metabolic markers |  | 24 h | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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milk protein, overweight, insulin metabolism, substrate partitioning