EEG Monitoring for PERFormance Anticipation

Study Overview
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Brief Summary
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Identify, characterize and then validate electrophysiological markers linking electrophysiological cerebral activity and performance in cognitive and physical fatigability in humans. To do this, noninvasive explorations of electroencephalography (EEG) and magnetoencephalography (MEG) will be carried out under two conditions of different experiments, the first one that induces a cognitive fatigability and the second one that induces physical fatigability.

Official Title
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Electrophysiological and Bioenergetic Study of Variations in Cognitive and Physical Performance in Healthy Humans: EEG Monitoring for PERFormance Anticipation

Conditions
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Healthy

Intervention / Treatment
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* Other: Electroencephalography (EEG) multi-sensor
* Other: Magnetoencephalography (MEG)
* Other: Behavioral Measures
* Other: Reaction time measurement
* Other: Assessment of physical performance
* Other: Electrooculogram (EOG)
* Other: Electromyogram (EMG)
* Other: Electrocardiogram with 3 leads
* Other: Electrodermogram (EDG)
* Other: Consumption of O2 (VO2)
* Other: Production of CO2 (VCO2)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria MGPFco group: Adult subjects, male or female, right-handed or left-handed, from 18 years up to 70 years; Having duly completed the entire confidential medical questionnaire; Written consent of free, informed and express participation; No hearing problems; Having normal or corrected vision; Affiliation to a Social Security scheme. Inclusion Criteria MGPFph group: Adult subjects, male or female, right-handed or left-handed, from 18 years up to 35 years; Practicing at least five hours of sports per week; Presenting a certificate of no contraindication to an exercise test, intense sports practice or an energy sport in competition of the current year; Having duly completed the entire confidential medical questionnaire; Without cardiovascular or motor disability; Without tumoral, inflammatory, cardiac, pulmonary, renal, digestive (malabsorption syndrome) or liver disease; Written consent of free, informed and express participation; Affiliation to a Social Security scheme. Exclusion Criteria: Pregnant women, nursing mothers or those of childbearing age without contraception Persons under guardianship, curatorship or any other administrative or judicial measure of deprivation of liberty or of liberty Persons protected by the law Persons who have performed a maximum stress test within 15 days of the date of inclusion, In the course of drug treatments against indicated for the protocol (treatment for neurological diseases, psychiatric ...). Metal implants incompatible with MRI (for the subjects concerned, see appendices) Metallic implants incompatible with the MEG (for the subjects concerned, see appendices)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Cognitive Fatigability<br> | Other: Electroencephalography (EEG) multi-sensor<br>* Electrophysiological measurements of cerebral activity will be performed by multi-sensor electroencephalography (EEG), which is a non-invasive method.<br>Other: Magnetoencephalography (MEG)<br>* Electrophysiological measurements of brain activity will be performed by magnetoencephalography (MEG) which is a non-invasive method.<br>Other: Behavioral Measures<br>* The evaluation of cognitive performance will be carried out by means of behavioral measures, push-button type, handling of a mouse or a joystick.<br>Other: Reaction time measurement<br>* The assessment of cognitive performance will be carried out using standard behavioral measures, such as reaction time measurement.<br>Other: Assessment of physical performance<br>* The assessment of physical performance will be based both on bioenergetic measurements and on quantitative data collected in continuous and relative to the effort (eg instantaneous pedaling speed).<br>Other: Electrooculogram (EOG)<br>* In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.<br>Other: Electromyogram (EMG)<br>* In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.<br>Other: Electrocardiogram with 3 leads<br>* In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.<br>|
| Other: Physical Fatigability<br> | Other: Electroencephalography (EEG) multi-sensor<br>* Electrophysiological measurements of cerebral activity will be performed by multi-sensor electroencephalography (EEG), which is a non-invasive method.<br>Other: Magnetoencephalography (MEG)<br>* Electrophysiological measurements of brain activity will be performed by magnetoencephalography (MEG) which is a non-invasive method.<br>Other: Behavioral Measures<br>* The evaluation of cognitive performance will be carried out by means of behavioral measures, push-button type, handling of a mouse or a joystick.<br>Other: Reaction time measurement<br>* The assessment of cognitive performance will be carried out using standard behavioral measures, such as reaction time measurement.<br>Other: Assessment of physical performance<br>* The assessment of physical performance will be based both on bioenergetic measurements and on quantitative data collected in continuous and relative to the effort (eg instantaneous pedaling speed).<br>Other: Electrooculogram (EOG)<br>* In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.<br>Other: Electromyogram (EMG)<br>* In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.<br>Other: Electrocardiogram with 3 leads<br>* In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.<br>Other: Electrodermogram (EDG)<br>* In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.<br>Other: Consumption of O2 (VO2)<br>* In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.<br>Other: Production of CO2 (VCO2)<br>* In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Identify electrophysiological markers in humans depending on whether the experimental conditions induce cognitive fatigability. | The evaluation of cognitive performance will be carried out by means of conventional behavioral measures, of the press-button type, handling of a mouse or of a joystick and measurement of reaction time. | 7 hours | 
| Identify electrophysiological markers in humans depending on whether the experimental conditions induce physical fatigability with EEG. | Electrophysiological measurements of cerebral activity will be performed by multi-sensor electroencephalography (EEG). | 7 hours | 
| Identify electrophysiological markers in humans depending on whether the experimental conditions induce physical fatigability with MEG. | Electrophysiological measurements of cerebral activity will be carried out by magnetoencephalography (MEG) | 7 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Refine (locate at the level of the cortex), the origin of these physiological markers | Several types of recordings, passive and non-invasive, will be realized: Electrooculogram (EOG); electromyography (EMG); electrocardiogram (ECG); Systematically in physical experiments and for some cognitive experiments. | 7 hours | 
| Distinguish between different time scales of performance | Several types of recordings, passive and non-invasive, will be realized: electrodermogram (EDG); the consumption of O2 (VO2); production of CO2 (VCO2). Only and systematically, in physical experiments. | 7 hours |