Postoperative Complications After Liver Transplantation

Study Overview
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Brief Summary
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Incidence and risk factors for renal, cardiovascular and pulmonary complications after liver transplantation are not well defined. Blood products requirement is an important aspect of orthotropic liver transplantation (OLTx) management and has a great impact on patient's outcome. Transfusions of blood products increase perioperative complications and reduce graft and patients survival. The primary endpoint of the study is to evaluate the incidence of renal complication during ICU stay after liver transplantation using RIFLE criteria; secondary endpoint is to evaluate the incidence of cardiovascular and pulmonary complications. In addition patients' survival and the relationship between blood components use with the development of post-operative complications are evaluated.

Detailed Description
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It is conducted a prospective observational cohort study in all Italian liver transplant centers. Adult (> 18 years old) recipients of deceased liver graft between January 2011 and December 2013 were eligible for inclusion. Exclusion criteria were the use of living organ donation, retransplantation, pediatric transplantations, combined transplantation and fulminant hepatic failure. Investigators collected data using a prospectively maintained computer database managed by the Italian Ministry of Health Centro Nazionale Trapianti. Anesthetic and perioperative management followed the routine local institution protocols.

Official Title
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Postoperative Renal, Pulmonary, Cardiovascular Complications and Use of Blood Components in Patients Undergoing Liver Transplantation

Conditions
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Liver Transplantation, Postoperative Renal Complication, Postoperative Pulmonary Complication, Postoperative Cardiovascular Complication, Blood Components Transfusion

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 years old or more Exclusion Criteria: Age less than 18 years; Liver transplantation living related donor; Retransplantation; combined transplantation; fulminant hepatic failure;

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of renal complication after liver transplantation | The primary endpoint of the study is to evaluate the incidence of renal complication during ICU stay after liver transplantation using RIFLE criteria | At 72 post operative hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of cardiovascular complication after liver transplantation | To evaluate the incidence of postoperative cardiovascular complications | During ICU length of stay, an average of 4 days. | 
| Incidence of pulmonary complication after liver transplantation | To evaluate the incidence of postoperative pulmonary complications | During ICU length of stay, an average of 4 days. | 
| Number of patients alive after liver transplantation that required blood components transfusion | To investigate the relationship of cardiovascular, pulmonary, renal complications after liver transplantation and the blood components consumption with mortality | At 1 year and at 3 years after liver transplantation |