Mindfulness Intervention to Study the Neurobiology of Depression

Study Overview
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Brief Summary
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The Pediatric Mood Disorders Program at the University of Illinois at Chicago is conducting a research study examining how mindfulness can help teenagers stay healthy and prevent depression relapse.

Detailed Description
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Study involves: Brain scan using fMRI technology Questions about mood and behavior Meeting with a clinician Possibility of 8 weekly treatment sessions using mindfulness Ongoing assessment of depression for next 2 years Eligible participants will be compensated for their time.

Official Title
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Mindfulness Intervention to Study the Neurobiology of Depression

Conditions
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Depression

Intervention / Treatment
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* Behavioral: Rumination-Focused Cognitive Behavior Therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: between the ages of 12 and 18 history of major depressive disorder Exclusion Criteria: braces afraid of small spaces

Ages Eligible for Study
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Minimum Age: 12 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Treatment<br>Participants randomized to the experimental condition will receive 8 weeks of individual treatment with Rumination-Focused Cognitive Behavior Therapy | Behavioral: Rumination-Focused Cognitive Behavior Therapy<br>* This intervention targets rumination and other maladaptive forms of emotion regulation such as suppression and avoidance and provides skills training in effective coping strategies. Mindfulness is a key component of this intervention as a strategy for disengaging from one's thoughts. Strategies from Dialectical Behavior Therapy (DBT), such as the use of effective interpersonal skills, are also included as methods for regulating strong emotion. Rumination-Focused Cognitive Behavior Therapy is a structured, manual based program designed to be delivered weekly over eight weeks. Sessions are 60-90 minutes in length.<br>|
| No Intervention: Control<br>Participants randomized to the control arm will complete questionnaires and receive mood monitoring for the duration of the study | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Children's Depression Rating Scale - Revised | clinician measure completed with adolescent and parent Total scores reported. Range is between 17-119 Higher scores mean higher depressive symptoms | Baseline, 8 week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Reynolds Adolescent Depression Scale | Self report adolescent depression total score. Range is 30-120 with higher scores meaning greater depressive symptoms. | Baseline, 8 week | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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mindfulness, relapse prevention, recovery, depression, adolescents