Multimodal Analgesia With Acetaminophen vs. Narcotics Alone After Hip Arthroscopy

Study Overview
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Brief Summary
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The purpose of this proposed study is to evaluate the efficacy of a multimodal approach to analgesia for patient's pain after hip arthroscopy and to also assess if this new approach will result in a reduction in post-operative narcotic use. This study is a single-center, randomized prospective study comparing post-operative pain scores and narcotic consumption between individuals receiving acetaminophen along with a reduced quantity of Percocet (to be used as needed for breakthrough pain) and individuals receiving Percocet only. Both pain management options are considered to be standard of care. Both cohorts will receive aspirin for DVT prophylaxis and celecoxib for heterotopic ossification prophylaxis. The primary objective of the study are to compare patients' narcotic consumption and reported pain following arthroscopic hip surgery, and determine if acetaminophen can provide adequate pain relief compared to a narcotic medication.

Official Title
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Multimodal Analgesia With Acetaminophen vs. Narcotics Alone After Hip Arthroscopy

Conditions
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Hip Arthroscopy

Intervention / Treatment
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* Drug: Acetaminophen
* Drug: Percocet


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA class I-II Patients indicated and scheduled for arthroscopic hip surgery Exclusion Criteria: Contraindication to acetaminophen or oxycodone/acetaminophen (e.g. hypersensitivity, history of GI or bleeding disorder) Legally incompetent or mentally impaired (e.g. minors, Alzheimer's subjects, dementia, etc.) Younger than 18 years of age or older than 65 Any patient considered a vulnerable subject Patients on pain medication prior to surgery

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Acetaminophen along with a reduced quantity of Percocet<br> | Drug: Acetaminophen<br>* acetaminophen 600 mg to be taken every 8 hours (TID)<br>Drug: Percocet<br>* Oxycodone/acetaminophen (Percocet) 5 mg/325 mg as needed for breakthrough pain for patients in Percocet+ Acetaminophen group. Percocet Group will receive standard of care Percocet 5 mg/325 mg every 6 hours PRN<br>|
| Experimental: Percocet only<br> | Drug: Percocet<br>* Oxycodone/acetaminophen (Percocet) 5 mg/325 mg as needed for breakthrough pain for patients in Percocet+ Acetaminophen group. Percocet Group will receive standard of care Percocet 5 mg/325 mg every 6 hours PRN<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient Satisfaction | Satisfaction was reported on a Likert-type scale of 1-10 (the higher the score, the higher the satisfaction) | 7 days post-surgery | 
| Morphine-equivalent Consumption | Amount of oxycodone/acetaminophen (Percocet) in 5mg/325mg doses will be recorded in number of pills | 7 days post-surgery | 
| Score on Visual Analog Scale (VAS) of Pain | Pain severity scores at rest will be assessed by use of VAS. The visual analog scale (VAS) is a validated, subjective measure for acute and chronic pain. Scores are recorded by making a handwritten mark on a 10-cm line that represents a continuum between no pain and worst pain. The higher the score, the worse the pain. | 24 hours post-surgery | 
| Score on Visual Analog Scale (VAS) of Pain | Pain severity scores at rest will be assessed by use of VAS. The visual analog scale (VAS) is a validated, subjective measure for acute and chronic pain. Scores are recorded by making a handwritten mark on a 10-cm line that represents a continuum between no pain and worst pain. The higher the score, the worse the pain. | 4 days post-surgery | 
| Score on Visual Analog Scale (VAS) of Pain | Pain severity scores at rest will be assessed by use of VAS. The visual analog scale (VAS) is a validated, subjective measure for acute and chronic pain. Scores are recorded by making a handwritten mark on a 10-cm line that represents a continuum between no pain and worst pain. The higher the score, the worse the pain. | 7 days post-surgery |