Exercise and Overnight Motor Sequence Task

Study Overview
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Brief Summary
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The objective of this randomized controlled trial (RCT) is to compare the changes of the sleep-related memory functions in patients with psychosis after they have completed the 12-week high-intensity exercise intervention, the 12-week low-intensity exercise intervention, or the 12-week controlled non-exercise intervention respectively. Fifty-one patients with psychosis, patients who received either the high-intensity exercise or low-intensity exercise as intervention shown a significant improvement to their impaired sleep-related memory function, while those who received non-exercise intervention has no such improvement. Moreover, high-intensity exercise may have a more prominent effect compare to low-intensity exercise.

Official Title
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12-week Aerobic-Anaerobic Transition Exercise Intervention and Overnight Sleep-dependent Procedural Memory Consolidation in Patients With Schizophrenia

Conditions
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Schizophrenia and Related Disorders, Psychotic Disorders

Intervention / Treatment
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* Other: Exercise
* Other: Non-exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged from 18 to 55 Based on the SCID diagnosed to have schizophrenia and related psychotic disorders Ability to understand the nature of the study and to give written informed consent Exclusion Criteria: Severe physical illness (Myocardial Infarction, Hypertension, Fracture, Spinal problems in which exercise may be contraindicated), and seizure disorders Comorbid substance dependence Unstable psychotic symptoms A history of brain trauma or organic brain disease Known history of intellectual disability or special school attendance Answered one or more yes in the PAR-Q and without doctors approval for exercise

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: High-endurance group<br>This group of subjects will receive 2-3 sessions of high-intensity cycling exercise training per week, for a total of 12 weeks. The exercise the subjects received will interchange between the aerobic and anaerobic state. | Other: Exercise<br>* Indoor cycling exercise intervention<br>|
| Experimental: Low-endurance group<br>This group of subjects will receive 2-3 sessions of low-intensity cycling exercise training per week, for a total of 12 weeks. The exercise the subjects received will maintain at an aerobic level. | Other: Exercise<br>* Indoor cycling exercise intervention<br>|
| Active Comparator: Psycho-education<br>This group of subjects will receive 2-3 sessions of psycho-education class per week, for a total of 12 weeks. The content of the class includes non-exercise related psycho-education content to participants (e.g., food hygiene, psychological well being, food nutrition, etc). | Other: Non-exercise<br>* Psycho-education<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The sleep-dependent procedural memory consolidation after 12 weeks of intervention | Tested by comparing the finger-tapping motor sequence task performance between the three groups during the 12-week follow-up assessment. | 12-week Follow-up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The verbal memory consolidation after 12 weeks of intervention | Tested by comparing the logical memory task performance between the three groups during the 12-week follow-up assessment | 12-week Follow-up | 
| The attention performance after 12 weeks of intervention | Measured by using the cancellation task performance and compare between the three groups during the 12-week follow-up assessment | 12-week Follow-up | 
| The sleep quality after 12 weeks of intervention | Measured by using the Pittsburgh Sleep Quality Index (PSQI) and compare the differences between the three groups during the 12-week follow-up assessment | 12-week Follow-up | 
| The insomnia severity after 12 weeks of intervention | Measured by using the Insomnia Severity Index (ISI) and compare the differences between the three groups during the 12-week follow-up assessment | 12-week Follow-up | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Exercise, Sleep-dependent memory consolidation, Aerobic, Anaerobic