Predictive Models of Treatment Responses and Survival Outcomes in Patients With Soft Tissue Sarcoma

Study Overview
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Brief Summary
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The aim of this study was to developed and validated models to predict therapeutic responses and patients' survivals in patients with soft tissue sarcoma and compared these models with currently available models.

Detailed Description
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We performed a retrospective-prospective cohort study with the aim of developing and validating comprehensive models to predict treatment responses and survival outcomes in patients with biopsy-proven soft tissue sarcoma. Secondly, we aimed to compare the predictive accuracy with currently available noninvasive model.

Official Title
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Predictive Models of Treatment Responses and Survival Outcomes in Patients With Soft Tissue Sarcoma

Conditions
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Soft Tissue Sarcoma

Intervention / Treatment
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* Other: Prediction model


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Receiving no treatment before diagnosis With written informed consent Exclusion Criteria: Clinical data missing Without written informed consent
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Retrospective cohort<br>The internal cohort was retrospectively enrolled in West China Hospital, Sichuan University from June 2010 and December 2020. It is a training and internal validation cohort. | Other: Prediction model<br>* We develop and validate clinical models to predict treatment responses and survival outcomes in patients with biopsy-proven with soft tissue sarcoma.<br>|
| Prospective cohort<br>The same inclusion/exclusion criteria were applied for the same center prospectively. It is an external validation cohort. | Other: Prediction model<br>* We develop and validate clinical models to predict treatment responses and survival outcomes in patients with biopsy-proven with soft tissue sarcoma.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Treatment response | The primary outcome was the evaluation of treatment response to individualized therapy in patients with soft tissue sarcoma. | At least 1-year follow up | 
| Progression-free survival outcomes | The endpoint was defined as the occurrence of progression or recurrence, or the last follow-up. Patients were followed from the day of histological diagnosis until the occurrence of progression or recurrence, or last visit. The outcome was evaluated by an experienced oncologist in each center every 3-6 months. At each visit, a medical history, physical examination, and standard laboratory tests were performed. | At least 5-year follow up | 
| Overall survival outcomes | The endpoint was defined as the occurrence of death or the last follow-up. Patients were followed from the day of histological diagnosis until the occurrence of progression or recurrence or last visit. The outcome was evaluated by an experienced oncologist in each center every 3-6 months. At each visit, a medical history, physical examination, and standard laboratory tests were performed. | At least 5-year follow up |