Obesity, Physical Inactivity or Dietary Fat ?

Study Overview
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Brief Summary
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Obesity is the consequence of a chronic disequilibrium of fat balance. Genetic factors determine predisposition to obesity, but the most often mentioned idea is that environmental factors, such as a high-fat diet and a sedentary lifestyle, join to favour weight gain and explain the increased prevalence of obesity in our westernized societies. Since lipogenesis is negligible in humans, obesity represents the consequence of altered fat partitioning between oxidation and storage, likely due to a preferential directing of dietary fat towards adipose tissue and away from muscle. Interventions that favour partitioning of dietary fat towards muscle for oxidation might thus protect against weight gain. Exercise may be one kind of such intervention but the scant data on dietary fat metabolism does not allow clear conclusions, in particular in obese subjects. One question concerns the impact of the type of fat eaten: the effects of physical inactivity may vary according to the length and saturation degree of the fatty acids. We hypothesize that 1) physical activity of moderate intensity, independently of its effect on energy balance, will favor a preferential trafficking towards adipose tissue, will modify the expression of genes implicated in fat oxidation and storage and partly correct the abnormalities observed in obese subjects, 2) effects of physical activity vary according to the saturation degree of fat. Twelve obese subjects, aged 18 to 55, will undergo tests before and after 2 months of training at current recommendations to ascertain dietary fat partitioning using stable isotopes and to determine changes in gene expression with muscle and adipose tissue microbiopsies.

Official Title
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OBESITY, PHYSICAL INACTIVITY OR DIETARY FAT ? Role of Physical Activity in the Trafficking of Dietary Fatty Acids Varying in Length and Saturation Degree.

Conditions
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Obesity

Intervention / Treatment
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* Behavioral: Physical training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men between 18 and 55 IMC >25 and <30 kg/m2 and waist circumference >102 cm Familial antecedents of obesity Physical inactivity (PAL<1.5, according to MOSPA-questionnaire and accelerometry) Acceptation of physical training and body weight control during the study Exclusion Criteria: Any drug interfering with energetic or lipid metabolism Any contradiction to moderate physical training Diabetes or arterial hypertension treatment Any other pathology (cardiovascular, psychiatric, renal or hepatic disease, viral hepatitis or VIH) Consumption of more than 40 g alcohol per day Recent voluntary or involuntary weight modification (3kg the next three months) A recent trip outside France before and during stable isotope measures.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Physical training|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of fat oxidation induced by physical training, according to fat type (oleate vs palmitate) |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Variations of oleate and palmitate postprandial kinetic in different lipoprotein fractions |  |  | 
| Expression of different muscle and adipose tissue genes |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Obesity, Exercise, Fat oxidation, Overweigh (IMC>25 and IMC<30)