Arthroscopic Partial Meniscectomy Time Window

Study Overview
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Brief Summary
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The purpose was to assess knee function outcomes between early arthroscopic partial meniscectomy(APM) and delayed APM for patients with degenerative meniscus lesions(DMLs)

Detailed Description
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Whether early APM surgery or delayed APM surgery will more benefit for patients with DMLs. The study was to determine the early APM vs delayed APM effect on knee function outcomes for patients with DMLs for 1 year follow-up.

Official Title
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Effect of Early vs Delayed Arthroscopic Partial Meniscectomy on the Knee Function of Patients With Degenerative Meniscus Lesions

Conditions
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Meniscus Lesion

Intervention / Treatment
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* Procedure: early APM
* Procedure: delayed APM


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • Clinical diagnosis of degenerative meniscus lesions based on knee MRI Exclusion Criteria: • Must be able to have no acute knee injury such as car crash or acute sports injury; Must be able to have no knee surgeries history; Must be able to have no rheumatoid arthritis or serious knee osteoarthritis with deformity; Must be able to have no contraindications to MRI; Must be able to have no severe cardiopulmonary disease; Must be able to have no musculoskeletal or neuromuscular impairments ; Must be able to have good visual, hearing, or cognitive;

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: early APM<br>early APM within 3 and 6 month knee pain symptoms | Procedure: early APM<br>* early APM within 3 and 6 month knee pain symptoms<br>|
| Active Comparator: delayed APM<br>delayed APM within 6 and 12 month knee pain symptoms | Procedure: delayed APM<br>* delayed APM within 6 and 12 month knee pain symptoms<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the Knee Injury and Osteoarthritis Outcome Score (KOOS) change | The Knee injury and Osteoarthritis Outcome Score (KOOS) holds five subscales including: Pain (9 items); other Symptoms (7 items); Activities of Daily Living (ADL, 17 items); Sport and Recreation function (Sport/Rec, 5 items); and knee-related Quality of Life (QoL, 4 items). Each subscale is scored separately from zero (extreme knee problems) to 100 (no knee problems) | change from baseline up to 12 months | 
| International Knee Documentation Committee Subjective Knee Evaluation Form (IKDC Score) change | The International Knee Documentation Committee Subjective Knee Evaluation Form (IKDC) score questionnaire contains 18 items (7 items for symptoms, 1 item for sport activity, 9 items for daily activities, and 1 item for current knee function.) The total score is transformed to a value on a scale of 0 to 100, with 100 representing the highest knee function and 0 is the worst. | change from baseline up to 12 months | 
| Kellgren-Lawrence (K/L) grade change | Kellgren-Lawrence (K/L) grade via X ray | change from baseline up to 12 months | 
| the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) change | Te WOMAC is a self assessed health status scale for patients consisting of 24 items in three subscales of pain (5 items), stiffness (2 items), and physical function (17 items). All items are scored from 0 (asymptomatic) to 4 (very severe), and the total score ranges from 0 to 96, with higher scores indicating more severe symptoms | change from baseline up to 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| KOOS pain score change | The minimum is 0 points, the maximum is 4 points, from extreme knee problems to no knee problems. After the score of each part is calculated separately, it is converted into a percentage score by the conversion formula. | change from baseline up to 12 months | 
| KOOS symptoms score change | The minimum is 0 points, the maximum is 4 points, from extreme knee problems to no knee problems. After the score of each part is calculated separately, it is converted into a percentage score by the conversion formula. | change from baseline up to 12 months | 
| KOOS activities of daily living score change | The minimum is 0 points, the maximum is 4 points, from extreme knee problems to no knee problems. After the score of each part is calculated separately, it is converted into a percentage score by the conversion formula. | change from baseline up to 12 months | 
| KOOS function in sport and recreation score change | The minimum is 0 points, the maximum is 4 points, from extreme knee problems to no knee problems. After the score of each part is calculated separately, it is converted into a percentage score by the conversion formula. | change from baseline up to 12 months | 
| KOOS knee related quality of life score change | The minimum is 0 points, the maximum is 4 points, from extreme knee problems to no knee problems. After the score of each part is calculated separately, it is converted into a percentage score by the conversion formula. | change from baseline up to 12 months |