Effect of Anesthesia Induction on Cerebral Hemodynamic in Children

Study Overview
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Brief Summary
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General anesthesia induces hemodynamic changes, notably a reduction of arterial blood pressure going up to 30%, that may impact cerebral perfusion and oxygenation.The purpose of this study is to assess the impact of anesthesia on the cerebral oxygenation, the perfusion of the brain (assessed with transcranial doppler), and the depth of anesthesia in children between 6 months and 5 years old during the induction of general anesthesia (induced with sevoflurane and/or IV agents). It is expected that the cerebral hemodynamic will be maintained despite systemic variations.

Official Title
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Effect of Anesthesia Induction on Cerebral Hemodynamic in Children

Conditions
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Anesthesia; Reaction, Children, Only

Intervention / Treatment
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* Procedure: General anesthesia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: General anesthesia for elective surgery American Society of Anesthesiologists score 1 and 2 Written informed consent obtained from the parents or legal tutors. Exclusion Criteria: 3 unsuccessful attempts of IV access ultrasound device non available neurologic comorbidity

Ages Eligible for Study
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Minimum Age: 6 Months
Maximum Age: 5 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: General anesthesia|Children under general anesthesia for an elective surgery, aged between 6 months and 5 years old, ASA 1-2.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in NIRS values during induction | Changes in cerebral Near infra-red spectrometry values | baseline and 1 minute after intubation | 
| Changes in cerebral velocity of the middle cerebral artery during induction |  | baseline and 1 minute after intubation | 
| Changes of Response Entropy (RE) value during induction |  | baseline and 1 minute after intubation | 
| Changes of State Entropy (SE) value during induction | Depth of anesthesia | baseline and 1 minute after intubation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in NIRS values after induction |  | At 1 minute, 3 minutes after intubation and at the start of surgery | 
| Change in cerebral velocity of the middle cerebral artery after induction |  | At 1 minute, 3 minutes after intubation and at the start of surgery | 
| Changes of arterial blood pressure during induction |  | At baseline and 1 minute after intubation | 
| Changes of Response Entropy (RE) values after induction |  | At 1 minute, 3 minutes after intubation and at the start of surgery | 
| Endtidal Co2 after induction |  | 1 minute after intubation | 
| Changes of State Entropy (SE) value after induction |  | At 1 minute, 3 minutes after intubation and at the start of surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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General anesthesia, Children