Neutralizing Antibody Level After COVID-19 Vaccination

Study Overview
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Brief Summary
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serial of neutralizing antibody at 2, 4, 6, 9, 12 month after COVID-19 vaccination investigate the factors on antibody titer.

Detailed Description
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serial of neutralizing antibody at 2, 4, 6, 9, 12 month after COVID-19 vaccination 1) semi-quantitative measurement of neutralizing antibody at 2, 4, 6, 9, 12 month after COVID-19 vaccination 2) investigate the duration maintaining acceptable range (over 30% inhibition) investigate the factors on antibody titer at 2 month after vaccination 1) potential factors: age, sex, body weight, height, use of medication, use of antipyretics (NSAID or tyrenol), side effect of COVID-19 vaccination 2) correlation between antibody titer and potential factors Compare 4 diagnostic ELISA kit at 2 month after vaccination 1) measure neutralizung antibody using ELISA kits from 4 different companies 2) investigate correlation coefficient of antibody titer between companies

Official Title
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Neutralizing Antibody Level After COVID-19 Vaccination in Hospital Works.

Conditions
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Covid19

Intervention / Treatment
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* Diagnostic Test: COVID-19 neutralizing antibody


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthcare works after completion of COVID-19 vaccination 20-60 years sign the agreement of study Exclusion Criteria: serious underlying diseases

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: COVID-19 neutralizing antibody|This study enrolled persons already who received COVID-19 vaccination under government policy. We collect 5mL blood at 2, 4, 6, 9, 12 months after COVID-19 vaccination isolate serum and store in -80 degree deep freezer measure neutralizing Antibody|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| titer of neutralizing antibody after COVID-19 vaccination | semi-quantitative measurement of neutralizing antibody after COVID-19 vaccination | at 2month after COVID-19 vaccination | 
| titer of neutralizing antibody after COVID-19 vaccination | semi-quantitative measurement of neutralizing antibody after COVID-19 vaccination | at 4 month after COVID-19 vaccination | 
| titer of neutralizing antibody after COVID-19 vaccination | semi-quantitative measurement of neutralizing antibody after COVID-19 vaccination | at 6 month after COVID-19 vaccination | 
| titer of neutralizing antibody after COVID-19 vaccination | semi-quantitative measurement of neutralizing antibody after COVID-19 vaccination | at 9 month after COVID-19 vaccination | 
| titer of neutralizing antibody after COVID-19 vaccination | semi-quantitative measurement of neutralizing antibody after COVID-19 vaccination | at 12 month after COVID-19 vaccination | 
| body weight (Kg) | correlation between antibody titer and body weight: spearmann's correlation | at 2 month after COVID-19 vaccination | 
| body mass index (kg/m^2) | correlation between antibody titer and body weight: spearmann's correlation | at 2 month after COVID-19 vaccination | 
| Compare 4 diagnostic ELISA kit after COVID-19 vaccination | measure neutralizung antibody using ELISA kits from 4 different companies 2 months after COVID-19 vaccination investigate correlation coefficient of antibody titer between companies | at 2 month after COVID-19 vaccination |