Latent Tuberculosis Infection in Korean Health Care Workers

Study Overview
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Brief Summary
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The investigators aim to study the prevalence of latent tuberculosis infection (LTBI) using whole-blood interferon-r release assays, and determine the risk factors of LTBI in Korean health care workers.

Detailed Description
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Further study details as provided by Hanyang University Hospital

Official Title
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Latent Tuberculosis Infection in Korean Health Care Workers Using Interferon Gamma Releasing Assay

Conditions
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Latent Tuberculosis

Intervention / Treatment
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* Other: QFT-IT Test and other blood sampling


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Health care workers in University affiliated hospital Adult aged 20-65 Exclusion Criteria: Active tuberculosis Subjects diagnosed with HIV infection, malignancy Subjects having immunosuppressive drug therapy

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: health care workers<br>health care workers including doctors, nurses, technicians and orderly who were hired in 2016 at the Hanyang University Hospital | Other: QFT-IT Test and other blood sampling<br>* In all enrolled health care workers, QFT-IT Test and other blood sampling were performed.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of latent tuberculosis infection developed in Korean health care workers | The participants performed QuaniFERON-TB Gold In-Tube test (QFT-IT test) and blood sampling at enrollment. So, the length of time which from the start of the first test of very first participants to the end of test of very last participant is 3 months. The percentage of participants with LTBI in health care workers was evaluated. | Three months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Annual incidence of latent tuberculosis infection in Korean health care workers | QFT-IT test was performed at enrollment and repeated at point of one year after enrollment. So, the length of time which from the start of the first test of very first participants to the end of the second test of very last participant is 12 to 15 months. The percentage of participants with positive conversion in follow-up QFT-IT test (second test) was evaluated in participants who had negative results in the first QFT-IT test. Annual infection of LTBI was evaluated with the conversion of QFT-IT test through annual check up of QFT-IT test. | 1 year after first QFT-IT test (12-15 months) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Latent Tuberculosis, Interferons, Tuberculosis, Healthcare