Speech Processing in Stuttering

Study Overview
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Brief Summary
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This research is being done to better understand stuttering, specifically how people who stutter may process and/or produce speech. Eligible participants enrolled will complete a variety of computer and speech-based tasks on up to 2 visits.

Detailed Description
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The study team will update the record to include the secondary identification number once the NIH has released the funds.

Official Title
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Speech Processing in Stuttering

Conditions
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Stuttering, Stuttering, Childhood, Stuttering, Adult

Intervention / Treatment
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* Behavioral: Speech and non-speech tasks


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria (adults who do not stutter): 18-65 years old English as primary language Normal speech, language, hearing, cognition Exclusion criteria: (adults who do not stutter) Personal or family history of stuttering Major medical or psychiatric illness Inclusion criteria: (adults who stutter) Aged 18-65 years English as primary language Normal speech, language, hearing, cognition (other than stuttering) Currently stutters Exclusion criteria: (adults who stutter) Speech therapy within the past year Major medical or psychiatric illness Inclusion criteria: (children who do not stutter) Aged 6 to 17 years English as primary language Normal speech, language, hearing, cognition Exclusion criteria: (children who do not stutter) Personal or family history of stuttering Major medical or psychiatric illness Language/motor delay Inclusion criteria: (children who stutter) Aged 6 to 17 years English as primary language Normal speech, language, hearing, cognition (other than stuttering) Currently stutters Exclusion criteria: (children who stutter) Major medical or psychiatric illness Language/motor delay

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Adults who stutter (AWS)<br>Participants will have 2 visits. | Behavioral: Speech and non-speech tasks<br>* Participants will complete speech tasks such as listening to and/or producing speech and non-speech sounds.<br>|
| Other: Healthy Adults<br>Participants will have 2 visits. | Behavioral: Speech and non-speech tasks<br>* Participants will complete speech tasks such as listening to and/or producing speech and non-speech sounds.<br>|
| Experimental: Children who Stutter<br>Participants will have 1 visit. | Behavioral: Speech and non-speech tasks<br>* Participants will complete speech tasks such as listening to and/or producing speech and non-speech sounds.<br>|
| Other: Healthy Children<br>Participants will have 1 visit. | Behavioral: Speech and non-speech tasks<br>* Participants will complete speech tasks such as listening to and/or producing speech and non-speech sounds.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Phase locking value (PLV) - Session 1 speech tasks | The degree of synchronization will be measured by computing the PLV between subject's produced speech and the heard speech. The PLV is a vector with a value between 0 and 1 that reflects the phase difference between two signals. | Session 1 (up to 4 hours) | 
| Phase locking value (PLV) - Session 2 speech tasks | The degree of synchronization will be measured by computing the PLV between subject's produced speech and the heard speech. The PLV is a vector with a value between 0 and 1 that reflects the phase difference between two signals. Session 2 is for adults only. | Session 2 (up to 4 hours) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Phase locking value (PLV) - Non-speech tasks | The degree of synchronization will be measured by computing the PLV between subject's produced response and the auditorily presented stimuli. The PLV is a vector with a value between 0 and 1 that reflects the phase difference between two signals. | Session 1 (up to 4 hours) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Healthy children, Healthy Adults