Heart Failure-USB: Prediction and Progression

Study Overview
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Brief Summary
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This retrospective cohort study is to identify triggers of heart failure (HF) development and drivers of HF progression as well as the underlying cardiac disease (phenotype) to identify patients at risk and predict the clinical course of the disease. Data of patients who were hospitalized during the years 2010-2023 with acute coronary syndrome (ACS) and/ or with acute heart failure (AHF) will be collected and analyzed. In a subgroup cohort efficacy and safety of digoxin in patients with acute heart failure triggered by tachyarrhythmia will be evaluated.

Official Title
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Heart Failure-USB: Prediction and Progression

Conditions
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Acute Heart Failure, Acute Coronary Syndrome, Heart Failure

Intervention / Treatment
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* Other: medical chart review
* Other: data generated by direct IT export


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients hospitalized with a primary diagnosis of ACS Patients hospitalized with a primary or secondary diagnosis of AHF Exclusion Criteria: Existence of a documented statement of the patient against the scientific use of clinical data

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| acute coronary syndrome (ACS)<br>Outcome information (all-cause death, heart failure (HF) hospitalizations) of patients hospitalized with a primary diagnosis of ACS is analyzed. | Other: medical chart review<br>* data generated by medical review include Medical history, Medications at presentation, during hospitalization and at discharge, New York Heart Association (NYHA) class, Killip class, Electrocardiographic (ECG) data, echocardiographic data, Interventions (Percutaneous Coronary Intervention (PCI), Coronary Artery Bypass Graft (CABG), Implantable Cardioverter Defibrillator (ICD) implantation, Cardiac Resynchronization Therapy (CRT) Implantation), Outcome Information: all-cause death, HF hospitalizations<br>Other: data generated by direct IT export<br>* data generated by direct IT export include Anthropometric data (age, sex, height, weight), Vital signs, Laboratory data<br>|
| acute heart failure (AHF)<br>Outcome information (all-cause death, heart failure (HF) hospitalizations) of patients hospitalized with a primary or secondary diagnosis of AHF is analyzed. | Other: medical chart review<br>* data generated by medical review include Medical history, Medications at presentation, during hospitalization and at discharge, New York Heart Association (NYHA) class, Killip class, Electrocardiographic (ECG) data, echocardiographic data, Interventions (Percutaneous Coronary Intervention (PCI), Coronary Artery Bypass Graft (CABG), Implantable Cardioverter Defibrillator (ICD) implantation, Cardiac Resynchronization Therapy (CRT) Implantation), Outcome Information: all-cause death, HF hospitalizations<br>Other: data generated by direct IT export<br>* data generated by direct IT export include Anthropometric data (age, sex, height, weight), Vital signs, Laboratory data<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of all-cause death | number of all-cause death in patients hospitalized with ACS and AHF during the years 2010-2023. | 1 to 8 years after hospitalization | 
| number of HF hospitalizations | number of new HF hospitalizations in patients hospitalized with ACS and AHF during the years 2010-2023 | 1 to 8 years after hospitalization | 
| number of cardiovascular death | number of cardiovascular death in patients hospitalized with ACS and AHF | 1 to 8 years after hospitalization | 
| number of cardiovascular hospitalizations | number of cardiovascular hospitalizations | 1 to 8 years after hospitalization |