Anesthetics and Auditory, Visceral, and Heat Evoked Potentials

Study Overview
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Brief Summary
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The aim of the present study is to investigate and quantify the influence of commonly used anesthetics on auditory and pain evoked potentials.

Detailed Description
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During surgery patients are exposed to different auditory and sensory stimuli. In this study we investigate the influence of different anesthetics to alertness and nociception. In addition to auditory stimuli (AEP as a measure of sedation), Contact Heat Evoked Potential Stimuli (CHEPS), and esophageal evoked potentials from the lower 1/3 of the esophagus are measured to quantify the effects of anesthetics. 60 Volunteers are enrolled into this study. For each drug, three different levels are measured: level 1 no medication level 2 low dose of medication level 3 light sedation dose (volunteer responds to command) Four drugs are measured in the study: propofol, sevoflurane, S-ketamine and remifentanil.

Official Title
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Influence of Anesthetics on Sedation and Antinociception: an Analysis of Auditory Evoked, Visceral Evoked and Heat Evoked Potentials

Conditions
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Healthy

Intervention / Treatment
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* Drug: Propofol
* Drug: Remifentanil
* Drug: S-Ketamine
* Drug: Sevoflurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: American Society of Anesthesiologists (ASA) physical status 1-2 Exclusion Criteria: drugs that effect the central nervous system neurological or psychiatric diseases contraindications against propofol, sevoflurane, S-ketamine or remifentanil any damages or loss of hearing heartburn or any stomach diseases

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1<br>remifentanil | Drug: Remifentanil<br>* continuous infusion 0.05 mcg/kg/min 0.15 mcg/kg/min<br>|
| Active Comparator: 2<br>propofol | Drug: Propofol<br>* TCI 0.5 mcg/ml 1.0 mcg/ml<br>|
| Active Comparator: 3<br>sevoflurane | Drug: Sevoflurane<br>* via face mask 0.40 Vol% 0.80 Vol%<br>|
| Active Comparator: 4<br>s-ketamine | Drug: S-Ketamine<br>* continuous infusion 0.25 mg/kg/h 0.50 mg/kg/h<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| influence of different drugs on evoked responses |  | 2 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| discrimination of antinociceptive, visceral-perceptive and sedative effects of anesthetics |  | 2 hours | 
| quantification of anesthetic components of propofol, sevoflurane, S-ketamine and remifentanil |  | 2 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pain, SSEP, CHEPS, Propofol, Sevoflurane, S-Ketamine, Remifentanil, Healthy volunteers