Therapeutic Vaccination Followed by Treatment Interruption in HIV Infected Patients

Study Overview
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Brief Summary
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The aim of this trial is to find out if immune responses to HIV can be boosted in individuals who start medicines soon after being infected. If immune responses can be boosted to the virus, this may allow the body to control HIV without the need for medications. This study is designed to test a new strategy for boosting immune responses to HIV and to evaluate if these responses allow people to have control of HIV without medicines.

Detailed Description
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The novel strategy used in this trial is to mix a peptide vaccine with dendritic cells from individuals. The dendritic cells are normal cells in the blood that boost immune responses. In HIV uninfected people, dendritic cells have been found to strongly activate the types of immune responses that may be important in controlling HIV. HIV infected and HIV uninfected individuals in this study will receive one shot of dendritic cells alone followed by three monthly shots of dendritic cells plus vaccine. We will monitor the immune responses to the peptide vaccine during this time period. After completing the vaccinations, HIV infected patients will stop their HIV medications and their immune status (CD4 count) and viral load will be monitored closely over 12 weeks.

Official Title
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Immune Responses to Antigen-Bearing Dendritic Cells in HIV-Infected Individuals

Conditions
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HIV Infections

Intervention / Treatment
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* Biological: Dendritic Cells Pulsed with HIV antigens


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Both HIV infected and HIV uninfected individuals are eligible for this study. CD4 cell count of 400 cells/mm3 or greater at study entry If HIV infected, initiated anti-HIV medicines within 120 days of infection If HIV infected, HIV viral load < 50 copies/ml for at least 3 months prior to study entry Current medication regimen for at least 3 months prior to study entry A particular blood type (HLA-A*0201) Acceptable methods of contraception Exclusion Criteria: Received investigational drug or vaccine within 30 days prior to study entry On other immune-based therapy (e.g., interleukin-2, alpha interferon, immunoglobulin, thalidomide) within 30 days prior to study entry Megesterol acetate within 30 days prior to study entry Immunization within 4 weeks of study entry If hepatitis B virus (HBV) uninfected and at high risk for HBV infection, the patient will not be eligible until he or she has completed an HBV vaccine series. Unstable or severe medical condition, including active opportunistic infection requiring treatment History of Hashimoto's thyroiditis Cancer requiring chemotherapy within 6 months prior to study entry History of radiation therapy to axillary lymph nodes Significant laboratory abnormalities at study entry Pregnant or breastfeeding History of autoimmune disease (e.g., rheumatoid arthritis, systemic lupus erythematosus, autoimmune hepatitis, scleroderma, mixed connective tissue disorder) Allergy to gentamicin, tobramycin, streptomycin, or amikacin

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: Dendritic Cells Pulsed with HIV antigens|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Dendritic Cell, Immunotherapy, Acute HIV, Human Immunodeficiency Virus, AIDS, HIV Therapeutic Vaccine, Treatment Experienced, Treatment Interruption