Comparison of Skin Prick Testing and Intradermal Skin Test Result of Local and Imported Insect Allergen Extracts

Study Overview
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Brief Summary
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Comparison the results of skin prick testing and Intradermal skin test result of local and imported insect allergen extracts in patients with serious insect sting allergy reactions

Detailed Description
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The patients with serious insect sting allergy reactions were evaluated and skin prick test and intradermal test with local and imported insect allergen extracts were performed. Specific IgE for insects was also performed. The results of skin prick testing and Intradermal skin test of local and imported insect allergen extracts were compared. The results also compared with specific IgE to insects

Official Title
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Comparison of Skin Prick Testing and Intradermal Skin Test Result of Local and Imported Insect Allergen Extracts in Patients With Severe Insect Sting Allergy

Conditions
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Allergy to Arthropod Sting

Intervention / Treatment
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* Diagnostic Test: Local insect allergen extracts skin test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with severe insect allergy reaction Allow being done skin test and blood foe specific IgE Exclusion Criteria: Serious systemic diseases severe asthma pregnant or nursing severe and extended skin lesion

Ages Eligible for Study
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Minimum Age: 5 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Comparison of skin prick testing and Intradermal skin test result of local and imported insect allergen extracts in patients with severe insect sting allergy
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Skin test with local extract<br>Skin prick test and intradermal test with local stinging insect allergen extracts that develop in Immunological division of Siriraj hospital, mahidol University | Diagnostic Test: Local insect allergen extracts skin test<br>* Every patient received both local and commercial insect allergen extracts but in blinded methods<br>* Other names: commercial insect allergen extracts from ALK skintest;|
| Sham Comparator: Skin test with commercial extract<br>Skin prick test and intradermal test with commercial stinging insect allergen extracts that order from ALK company | Diagnostic Test: Local insect allergen extracts skin test<br>* Every patient received both local and commercial insect allergen extracts but in blinded methods<br>* Other names: commercial insect allergen extracts from ALK skintest;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of positive skin test results of local and commercial insect allergen extracts | Measure wheal size of skin test of local and commercial insect allergen extracts then compare the positive result and wheal size between local and commercial extracts. | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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insect sting allergy, Hymenoptera allergy, local insect allergen extracts