Extreme Lipids Repository

Study Overview
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Brief Summary
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This is a prospective, observational study to establish a repository of samples from patients with extreme lipid phenotypes including but not limited to hyperlipidemia, dyslipidemia, hyperlipoproteinemia, extreme low/high HDL levels and deranged lipoprotein metabolism. The investigators plan to conduct sophisticated composition and functional analyses as well as genetic analysis to better understand the determinants of extreme lipid derangements.

Detailed Description
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Participants will be recruited from clinical encounters within the University of Texas (UT) Southwestern Medical Center and Parkland Hospital by screening the Electronic Medical Record (EMR) for those with lipid labs and values that satisfy criteria for extreme values. Identified participants will be recruited to provide health information via survey, permission to extract clinical information from the EMR, and blood collection for future analyses. Measurements will span direct measurement of circulating species, genetic analyses, and analysis of circulating cells. The blood specimens will be stored for future studies and collaborations and thus, will constitute a blood-based repository. All study procedures are experimental but do not involve an actual intervention.

Official Title
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Extreme Lipids Repository

Conditions
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Lipoprotein Disorder

Intervention / Treatment
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* Other: No intervention is involved in this study


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adult patients (age 18 years or older) diagnosed with any lipid or metabolic disorder including hyperlipidemia, dyslipidemia, hyperlipoproteinemia, low HDL levels and deranged lipoprotein metabolism Exclusion Criteria: Anyone under 18 years of age will be excluded from the study.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with extreme lipid phenotypes<br>Adult patients (age 18 years or older) diagnosed with any lipid or metabolic disorder including hyperlipidemia, dyslipidemia, hyperlipoproteinemia, low HDL levels and deranged lipoprotein metabolism | Other: No intervention is involved in this study<br>* No intervention is involved in this study<br>|
| Healthy volunteers<br>Healthy adult volunteers with normal lipid metabolism will be recruited for the purpose of comparison | Other: No intervention is involved in this study<br>* No intervention is involved in this study<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Biological sample collection for repository | Blood samples will be collected for preparation of plasma and serum, extraction of DNA and isolation of circulating cells. Future analysis include genomic, proteomic and metabolomic analysis | Day 1 | 
| Data collection for repository | Demographic information, clinical history and lipid related bio-marker information will be collected from participants | Day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Lipoproteins, Cholesterol, High Density Lipoproteins