linjc16/ctgov huggingface dataset:
Evaluation of Capsular Bag Shape Changes After Plate-haptic Intraocular Lens Implantation by SS-OCT

Study Overview
=================
Brief Summary
-----------------
Evaluation of capsular bag shape changes after plate-haptic intraocular lens implantation by SS-OCT.

Detailed Description
-----------------
Eighty patients (80 eyes) with simple age-related cataracts were treated from December 2019 to December 2020 in the Wenzhou Medical University. Investigators specifically included patients who were bodily healthy and underwent a successful implantation of an IOL. Inclusion criteria for this study were patients who were older than 40 years old, had an axial length of 22-26mm, and could complete 4 follow-up visits.

Official Title
-----------------
Evaluation of Capsular Bag Shape Changes After Plate-haptic Intraocular Lens Implantation by SS-OCT.

Conditions
-----------------
Age-related Cataract

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: -patients who were older than 40 years old, had an axial length of 22-26mm, and could complete 4 follow-up visits. Exclusion Criteria: people cannot cooperate with the check， corneal opacity, glaucoma, and other eye diseases any other previous intraocular surgery, and intraoperative complications including anterior or posterior capsulartears Continuous circular capsulorhexis is not centered and Mydriasis is less than 7mm.

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1<br>implanted with the C-loop haptic intraocular lens | |
| Group 2<br>implanted with the plate haptic intraocular lens | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Capsular bend index (CBI) | capsule bend formation has 5 continuous stages from 0 to 4，The stage score varies over different positions of the same capsule bag, because the capsule bend formation is inconsistent along the entire optic edge. CBI is the mean of the different stage scores in different positions and represents the general capsule bend state of the whole capsule bag. | 2020.12.1 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
SS-OCT, capsule bag
The Clinical Significance of the Uncinate Process Histopathology in Chronic Rhinosinusitis

Study Overview
=================
Brief Summary
-----------------
Given that the uncinate process is the gatekeeper of the sinuses, we hypothesize that inflammation of the uncinate process is associated with decreased ventilation and drainage of the paranasal sinuses and consequently with the inflammatory process occuring in the sinuses.

Detailed Description
-----------------
The purpose of the present study is to gain insight into the histopathological changes of the uncinate process in patients with chronic rhinosinusitis through comparison of its mucosal and bony elements with those of the normal uncinate process without chronic inflammation (unpublished data: Gilead Berger, Ephraim Eviatar, Tatiana Kogan, Roee Landsberg).

Official Title
-----------------
New Insights on the Clinical Significance of the Uncinate Process Histopathology in Patients With Chronic Rhinosinusitis

Conditions
-----------------
Rhinosinusitis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with chronic rhinosinusitis who: Failed conservative medical treatment. Stopped treatment (topical or systemic corticosteroids) at least two months before endoscopic sinus surgery. Had a Lund-MacKay CT score of 2 and higher of 24 available. Exclusion Criteria: Immunosuppressed patients. Patients in whom a pathologic evaluation of the middle turbinate was necessary (e.g., suspected neoplastic disorder). Patients with a Lund-MacKay CT score < 2 of 24 available. Pregnant women. Patients who underwent prior endoscopic sinus surgery.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sinus drainage<br>Adult patients with chronic rhinosinusitis who failed treatment with antibiotics and topical corticosteroids and underwent endoscopic sinus surgery. Preoperative evaluation included paranasal sinus CT scans. The diagnosis was confirmed by endoscopic examination showing purulent and/or mucopurulent discharge in the middle and/or superior meatus. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Chronic rhinosinusitis, Histopathology, Infundibulum, Lamina propria, Uncinate process
Ultrasound Guided Thoracic ESPB for Post Mastectomy Pain Control, Comparing 2 Dosing Regimens of Lidocaine With Different Drug Volumes

Study Overview
=================
Brief Summary
-----------------
The investigators compare 2 different drug regimens using 2 different volumes of lidocaine with the same drug content (i.e. different concentrations) as regards efficacy of post operative analgesia following mastectomy surgery

Official Title
-----------------
Ultrasound Guided Thoracic Erector Spine Plane Block for Post Mastectomy Pain Control, Effect of Volume With Constant Drug Mass, a Randomized Controlled Trial

Conditions
-----------------
Analgesia

Intervention / Treatment
-----------------
* Procedure: Erector spine plane block


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: ASA 2 & 3 for elective breast cancer surgery Exclusion Criteria: ASA > 3 BMI > 35 kg/m2 Contraindications to LA (coagulopathy and local infection) Allergy to the drug Cardiac, hepatic and renal patients

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: L group<br>Patients are given 20 ml of 2 % lidocaine for ESPB | Procedure: Erector spine plane block<br>* Thoracic ESPB<br>|
| Active Comparator: H group<br>Patients are given 40 ml of 1 % lidocaine for ESPB | Procedure: Erector spine plane block<br>* Thoracic ESPB<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effective analgesia | Morphine supplements needed | First 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analgesic efficiency | Visual analog scale; ranging from 0 to 10 where 0 is no pain and 10 is pain in its worst form | Every 2 hours in the first 24 hours |
The Initial Effect of Training on Mitochondrial Function in Patients With Intermittent Claudication

Study Overview
=================
Brief Summary
-----------------
The hypothesis of this study is that one bout of leg exercise gives acute qualitative changes in mitochondrial function in claudication. Final purpose is to determine the optimal exercise frequency in treatment of claudication.

Official Title
-----------------
The Initial Effect of Training on Mitochondrial Function in Patients With Intermittent Claudication

Conditions
-----------------
Intermittent Claudication

Intervention / Treatment
-----------------
* Behavioral: exercise


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: A history of any type of uni- or bilateral exertion leg pain. A maximal claudication distance that is less than 300 meter Diagnosed with intermittent claudication secondary to vascular insufficiency An ankle-brachial index between 0.4 and 0.9. Lives in Trondheim Exclusion Criteria: Diagnosed with critical limb ischemia ankle-brachial index > 0.90 or < 0.4 Limited exercise tolerance Warfarin or heparin usage Diabetes mellitus Underwent a vascular intervention in the last 3 months Active cancer, renal- or liver disease.

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| claudication<br> | Behavioral: exercise<br>* one bout of exercise training<br>|
| healthy<br> | Behavioral: exercise<br>* one bout of exercise training<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mitochondrial function | respirometry | One day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Mitochondria, Muscle, Exercise
A Comparison of Volatile Anesthesia and Total Intravenous Anesthesia (TIVA)

Study Overview
=================
Brief Summary
-----------------
In this study, investigators wanted to investigate the effect of volatile anesthesia and total intravenous anesthesia (TIVA) on ecchymosis, edema, and intraoperative bleeding in rhinoplasty.

Detailed Description
-----------------
Routine monitorization (blood pressure, pulse, oxygen saturation with pulse oximetry and electrocardiogram) will be applied to all patients taken into the operation room. In Group P (TIVA), induction of anesthesia will be achieved with 2 mg/kg propofol, 0.6 mg/kg rocuronium, and 1 μ / kg fentanyl. Propofol and remifentanil will be used in the continuation of anesthesia. In Group S (Volatile), anesthesia will be induced with 2 mg / kg propofol, 0.6 mg / kg rocuronium and 1 μ / kg fentanyl. 50% nitrous oxide + 50% oxygen and 2% sevoflurane will be used in the continuation of anesthesia. All patients will receive 2 ml/kg/hour Ringer's lactate solution during the operation.

Official Title
-----------------
A Comparison of Volatile Anesthesia and Total Intravenous Anesthesia (TIVA) on Ecchymosis, Edema, and Intraoperative Bleeding in Rhinoplasty

Conditions
-----------------
Rhinoplasty, Ecchymosis, Edema, Hemorrhage

Intervention / Treatment
-----------------
* Other: Different anesthesia methods


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Between 18 and 65 years Planned to rhinoplasty An American Society of Anesthesiologists score of 1 or 2 Exclusion Criteria: Steroid use Patients with coagulation disorders, •Rejected to participation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group P<br>Total intravenous anesthesia (TIVA) | Other: Different anesthesia methods<br>* Total intravenous anesthesia (TIVA)and volatile anesthesia<br>|
| Group S<br>Volatile anestesia | Other: Different anesthesia methods<br>* Total intravenous anesthesia (TIVA)and volatile anesthesia<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Edema and ecchymosis in rhinoplasty according to the type of anesthesia. | It is evaluation developing edema and ecchymosis according to total intravenous anesthesia and volatile anesthesia in rhinoplasty. | one time in six months |
Evaluation of Local Mechanisms for Staff Motivation to Reduce Hospital Mortality

Study Overview
=================
Brief Summary
-----------------
We observed in a randomised intervention trial in Bissau that mortality due to malaria could be reduced by half by adding a small monetary incentive to the staff and strict follow-up of a standard protocol for available drugs. The Government and donors are not able to sustain such incentives. We intend to evaluate whether strict organisation of a cost recovery system and the use of part of the funds for staff incentives would improve performance of the staff and contribute to reduction of hospital and post-discharge mortality.

Detailed Description
-----------------
A committee will organise collection and use of the money, and decide on incentives to be paid to the staff based on performance indicators. All children < 5 years of age admitted to the ward will be registered and followed-up until two months after the consultation. Data on the level of mortality before and after the study period will be collected. Furthermore, interviews on quality perception of the parents will be carried out before and after the study.

Official Title
-----------------
Evaluation of Local Mechanisms for Staff Motivation to Improve Treatment and Reduce Mortality Due to Malaria at the Paediatric Ward

Conditions
-----------------
Hospital Mortality, Malaria

Intervention / Treatment
-----------------
* Procedure: Staff incentive & supervision
* Behavioral: Staff motivation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children under five years of age admitted to the ward Parents of these children

Ages Eligible for Study
-----------------
Maximum Age: 59 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Staff incentive & supervision|Control & management of funds for incentive of staff; supervision|
|Behavioral: Staff motivation|Supervision, control of funds|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall hospital and malaria mortality |  | One year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Parent's perception of the quality of care received |  | One year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Staff motivation, Hospital mortality, Perception of quality of care
Reliability and Responsiveness of the Chinese Version of the Readiness for Return-To-Work Scale in Lost-time Claimants in Outpatient Occupational Rehabilitation in Taiwan

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to measure the reliability and responsiveness of the Chinese version of the readiness for return-to-work (RRTW) scale. We would conduct a multiple-centered, prospective cohort study to require RRTW data in lost-time claimants in outpatient occupational rehabilitation in Taiwan.

Official Title
-----------------
Reliability and Responsiveness of the Chinese Version of the Readiness for Return-To-Work Scale in Lost-time Claimants in Outpatient Occupational Rehabilitation in Taiwan

Conditions
-----------------
Occupational Injuries

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Clinical diagnosis of occupational injuries Participating the work hardening program Age from 20-65 Still not return to work Willing to participating the study Exclusion criteria: Cannot read the sentences or express their own idea, which causing the cannot finish the questionnaires Brain injuries (e.g. traumatic brain injury, cerebrovascular acciden

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of the Readiness for Return-To-Work Scale scores during rehabilitation | Using the RRTW scale changes of the pretest and protest data to calculate the responsiveness. | The participants do the pretest of RRTW scale in the first week in their work hardening program, finishing the protest in the last week before the program ends. The duration depends on people. (In an average of 4-6 weeks) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from the Readiness for Return-To-Work Scale scores at 1 week | Using the pretest and retest data of the Readiness for Return-To-Work (RRTW) scale to calculate the reliability. | The participants do the pretest of RRTW scale in the first week in their work hardening program, and they do the retest after one week. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
return to work, readiness for return to work, occupational injury, work hardening
Endothelin Blockade in Patients With Single Ventricle Physiology

Study Overview
=================
Brief Summary
-----------------
Recent studies have shown beneficial effects of sildenafil in patients with single ventricle congenital heart disease. The purpose of this study is to determine whether Bosentan, a drug with similar effects, will have similar benefit in this patient population.

Detailed Description
-----------------
Patients enrolled in the study will take Bosentan. Baseline and follow up measurements will be collected then analyzed.

Official Title
-----------------
Endothelin Blockade in Patients With Single Ventricle Physiology

Conditions
-----------------
Congenital Heart Disease

Intervention / Treatment
-----------------
* Drug: Bosentan


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: At least 12 years of age Single ventricle congenital heart disease Require cardiac magnetic resonance imaging (MRI) for clinical purposes. Exclusion Criteria: < 12 years of age Pregnancy or women who may become pregnant (sexually active and unwilling to use birth control) Patients taking cyclosporin or glyburide Patients with baseline liver dysfunction (aspartate aminotransferase or alanine aminotransferase > 3 times upper limit of normal) Contraindications to MRI (including pacemakers) Use of Bosentan within one month prior to enrollment

Ages Eligible for Study
-----------------
Minimum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Bosentan<br>Bosentan | Drug: Bosentan<br>* Bosentan 62.5 mg tablet taken orally twice daily for one month, followed by Bosentan 125 mg tablet taken orally twice daily for three months.<br>* Other names: Tracleer;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pulmonary Blood Flow as Determined by MRI Velocity Encoding at 3-6 Months | Magnetic resonance imaging-derived aortic flow | 3-6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Single ventricle congenital heart disease
Evaluation of OCT Measurements

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to repeatability, reproducibility and agreement of eye measurements in retina and glaucoma patients.

Detailed Description
-----------------
The purpose of the study is to repeatability, reproducibility and agreement of eye measurements in retina and glaucoma patients using OCT technology. There will be a series of measurements acquired from one eye on at least 2 different OCT devices. All testing will be completed in one visit.

Official Title
-----------------
Evaluation of the Precision and Accuracy of OCT Measurements in Retinal and Glaucoma Patients

Conditions
-----------------
Assess Eye Measurements in Patients Having Retina Pathology or Glaucoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Inclusion Criterea: At least 18 years of age Able and willing to provide consent Willing to complete the required examinations and visits Best corrected visual acuity equal or better than 20/100 Retina subject must have clinical diagnosis of retinal pathology Glaucoma subjects must have clinical diagnosis of glaucoma Exclusion Criteria: Unable to complete the required examinations and visits Poor OCT image quality as a result of media opacity, extreme refractive error or pathologies in the anterior segment Confounding pathology requiring surgical treatment or medical intervention

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Retina<br>Having clinical diagnosis of retina pathology | |
| Glaucoma<br>Having clinical diagnosis of glaucoma | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Retina thickness |  | Day 1 |