Vertical Transmission of Hepatitis C in Adult Children of Female Baby Boomers

Study Overview
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Brief Summary
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The investigators aim to determine the prevalence of hepatitis C in the adult children of female baby boomers. During the years baby boomers were becoming pregnant, hepatitis C testing was either not available or was not standard of care. Because of this, participants' children may be unaware of participants' risk of hepatitis C.

Official Title
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Vertical Transmission of Hepatitis C in Adult Children of Female Baby Boomers

Conditions
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Hepatitis C, Hepatitis C, Chronic

Intervention / Treatment
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* Other: Eligibility Screening
* Diagnostic Test: HCV test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Mothers: Born between 1/1/45-12/31/64 Black or white race Active or prior infection with hepatitis C Have at least one living adult child over the age of 18 Children: ≥18 years of age Born to mother with current or prior HCV infection, with likely timing of HCV acquisition prior to or during pregnancy Mother gave informed consent for child to be approached for study participation Exclusion Criteria: Mothers: - Unwilling to disclose hepatitis C status to children

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 72 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Mothers<br>Black or white mothers who have or have had hepatitis C and were born between 1945-1964. Participants must have at least one child over the age of 18. | Other: Eligibility Screening<br>* Investigators will call eligible mothers to screen for the possibility that eligible mothers may have passed HCV on to adult children. Investigators will consent these mothers to contact the adult child(ren), as the child(ren) must be informed of the mother's HCV status, if not already known.<br>|
| Adult Children<br>Adult children of Black or white mothers who have or have had hepatitis C and were born between 1945-1964. From speaking with these mothers, it must be possible that participants were exposed to hepatitis C virus while in the womb. | Diagnostic Test: HCV test<br>* Adult children will be invited to Penn or a Penn affiliate to have labwork, testing HCV antibody and HCV quant. If the quant comes back positive, investigators will also test genotype and fibrosure.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HCV prevalence | Prevalence of HCV in adult children of female baby boomers who have or have had HCV | Within 1 week of labwork at first study visit | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Liver fibrosis | Level of liver fibrosis (detected through fibrosure test) found in adult children diagnosed as HCV-positive | Within 2 weeks of diagnosis of HCV | 
| HCV genotype | HCV genotype for adult children diagnosed as HCV-positive | Within 6 weeks of diagnosis of HCV |