OCT-Angiography and Adaptive Optics in Patients With Memory Impairment

Study Overview
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Brief Summary
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Studies suggest an association between retinal abnormalities and NCD (Neuro Cognitive Disorders) whether they are linked to proven or prodromal Alzheimer's disease (aMCI : amnestic mild cognitive impairment), or to other neurodegenerative diseases such as frontotemporal dementia or Lewy body diseases. These retinal anomalies objectified by OCT-A (Optical coherence tomography angiography) and adaptive optics (AO) appear different depending on the pathologies and could therefore serve as markers in vivo of the pathophysiological processes underlying NCD. No study to date has studied the retina and its vessels in NCD using adaptive optics. In this pilot study, we are proposing a combination of two new ophthalmological imaging techniques (OCT-A and AO), which allow rapid in vivo analysis in a completely non-invasive way of the morphology of small vessels as well as architecture of the retina to better specify the retinal anomalies associated with NCD. We will compare the parameters in OCT-A and AO between patients with NCD and controls without NCD (with memory complaint or without) and will seek to determine if there are different profiles according to the causes of NCD.

Official Title
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OCT-Angiography and Adaptive Optics in Patients With Memory Impairment

Conditions
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Amnesia, Alzheimer Disease, Lewy Body Disease, Parkinsons Disease With Dementia

Intervention / Treatment
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* Procedure: Ophthalmological exam
* Procedure: Blood pressure measurement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient presenting in memory consultation for memory complaint or person accompanying a patient in memory consultation for memory complaint Exclusion Criteria: pregnant or lactating women history of known non-degenerative neurological pathology (tumor, stroke territorial, in particular multiple sclerosis) history of retinal pathology ametropia greater in absolute value than 3 diopters on the sphere, or/and 1.5 diopters on the cylinder. history of taking ethambutol for more than 2 months history of takingsynthetic antimalarial for more than 2 years Mini Mental State Score (MMS) and / or Montreal Cognitive Assessment (MoCA) <10 for patients and 26 for accompanying persons MRI contraindication (for patients only)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: NCD patients (case)<br>Patient diagnosed with Alzheimer's disease or parkinsonian dementia / Lewy body dementia or other mild or severe NCD defined by international criteria. | Procedure: Ophthalmological exam<br>* OCT-A and AO<br>Procedure: Blood pressure measurement<br>* Blood pressure measurement before the ophthalmological exam<br>|
| Other: Control patients with memory complaint<br>Normal neuropsychological evaluation during assessment | Procedure: Ophthalmological exam<br>* OCT-A and AO<br>Procedure: Blood pressure measurement<br>* Blood pressure measurement before the ophthalmological exam<br>|
| Other: Control patients without memory complaint<br>MMS score and / or the Montreal Cognitive Assessment grid (MoCA) ≥26 / 30, No memory complaint | Procedure: Ophthalmological exam<br>* OCT-A and AO<br>Procedure: Blood pressure measurement<br>* Blood pressure measurement before the ophthalmological exam<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Wall to lumen ratio (WLR) | Measured in adaptive optics, compared between patients case with NCD and patient controls without NDC found | Baseline (Inclusion) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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OCT-A, adaptative optics