Oocyte Freezing for Fertility Preservation in Benign Ovarian Tumors

Study Overview
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Brief Summary
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Benign ovarian cysts are frequent during women's life. They are diagnosed with pelvic pain or fortuitously during an ultra-sonographic exam. In case of persistence,a surgery will be necessary to identify the nature of the cyst and assess its benignity. In some case, cysts are recurrent and multiple surgeries are needed leading to a significant risk of ovarian damage by follicular depletion. Oocyte cryopreservation is no longer considered as an experimental technique of Fertility Preservation since 2013 as it has been recognized to be efficient and safe. According to reproductive medicine scientific committees and the French ethic law, fertility preservation has to be proposed in every situation of infertility risk. To date, there is no cohort study dedicated to fertility preservation by oocyte freezing in this specific subgroup of patients. The purpose of the study is to prospectively evaluate the oocyte number and quality after controlled ovarian hyperstimulation in patients with recurrent ovarian cysts.

Official Title
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Systematic Proposal of Fertility Preservation by Oocyte Freezing in Case of Benign Ovarian Tumors With High Risk of Recurrence

Conditions
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Endometriosis, Dermoid Cyst, Mucinous Cyst

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: women with benign ovarian tumor with high risk of recurrence, i-e, endometrioma, dermoid cysts or mucinous cysts. women with previous surgery and/or high risk of ovarian damage: bilateral cysts, cyst diameter higher than 5 cms Having a social insurance Able to give an informed consent Exclusion Criteria: Borderline tumors Undetectable AMH levels Personal history of thrombo-embolic events pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of mature oocytes eligible for cryopreservation |  | After 15 days of controlled ovarian hyperstimulation (COH) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of immature or morphologically abnormal oocytes |  | Real-time, the day of egg retrieval | 
| Number of mature follicles (≥15 mm) and intermediary (10-14 mm) during ovarian stimulation |  | The day of HCG triggering at the end of ovarian stimulation | 
| Questionnaire on tolerance and complications | A systematic telephone interview will be carried out 48 to 72 hours after the oocyte puncture to judge the tolerance of the procedure. | One week after the egg retrieval | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Oocyte freezing, fertility preservation, ovarian cysts, benign ovarian tumor, endometrioma