linjc16/ctgov huggingface dataset:
Evaluation of Lung Atelectasis During Apneic Oxygenation Using THRIVE in Adults During Laryngeal Surgery.

Study Overview
=================
Brief Summary
-----------------
Oxygenation with high-flow nasal cannula with 100% oxygen have now been evaluated in a number of studies and the data are convincing. The THRIVE technique is able to oxygenate patients safely and vital parameters has been shown to be stable. But it is of great importance to evaluate this new concept regarding other potential negative physiological aspects such as lung atelectasis and inflammatory stress response before implementing it into clinical practice.

Official Title
-----------------
Evaluation of Lung Atelectasis During Apneic Oxygenation Using Trans Nasal Humidified Rapid Insufflation Ventilatory Exchange (THRIVE) in Adults During Laryngeal Surgery.

Conditions
-----------------
Anesthesia

Intervention / Treatment
-----------------
* Device: THRIVE
* Device: Endotracheal intubation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adults, >18 years old. ENT-surgery where apnea is of benefit for the surgeon (eg. intraoral or laryngeal surgery). Capable of understanding the study information and sign the written consent. Exclusion Criteria: ASA>2 NYHA >2 Pacemaker or ICD. BMI >35 Pregnancy Manifest cardiac failure or coronary disease Severe gastrointestinal reflux. Neuromuscular disorder

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Intubation<br>The patients will be intubated and ventilated | Device: Endotracheal intubation<br>* Ventilation during the procedure is governed by an endotracheal tube in the trachea and mechanical ventilation<br>|
| Experimental: THRIVE<br>The patients will be oxygenated during apnea using THRIVE | Device: THRIVE<br>* Oxygenation during apnea using transversal humidified oxygen<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Electrical impedans tomography | Changes in lung volumes | baseline, intraoperative, 2 hours after start of intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in Endtidal and arterial carbon dioxide partial pressure in the end of the procedure | Difference in Endtidal and arterial carbon dioxide partial pressure in the end of the procedure | max 30 minutes after start of intervention | 
| Increase in arterial carbon dioxide during the apnea | Measurement of arterial blood gases and here arterial carbon dioxide | max 30 minutes after start of intervention |
Agitation in the Acute Psychiatric Department

Study Overview
=================
Brief Summary
-----------------
Agitation is associated with a number of acute psychiatric conditions, and frequent in acute psychiatric admissions. It is associated with violence towards others, and strongly associated with in-patient suicides. The main aims of the study are to assess different clinical presentations of agitation at admittance, and to assess the consequences of these different clinical presentations during the first three days of the stay.

Detailed Description
-----------------
The patients are assessed with three rating scales (Components of agitation, The PANSS-EC, The Brøset Violence Checklist) measuring agitation at admittance and day three thus providing a measurement of the differences during three days of in-patient stay. Therapeutic measures and interventions taken are assessed daily with a 18-item checklist. Threatening and violent incidents are recorded with The SOAS-R. Blood samples for immunological parameters are taken at admittance and discharge giving opportunity to assess changes through the acute psychiatric condition. Urine and blood samples are taken at admittance to assess substance use and medications. The patients are assess with two self-rating VAS-scales at discharge assessing the suicidal intentions they have had during the stay, aspects of clinical history and assessment for personality disorders.

Official Title
-----------------
Agitation in the Acute Psychiatric Department

Conditions
-----------------
Mental Disorders

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All consecutive acutely admitted in-patients are asked for participation. Exclusion Criteria: Patients not willing to sign informed consent form. Patients not speaking English or Norwegian.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Acutely admitted psychiatric in-patients<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the number of violent or threatening incidents the first three days of inpatient stay measured with The Staff Observation Aggression Scale - Revised (SOAS-R) with positive scorings of incidents with a severity score >8. |  | Up to 4 years. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the degree of suicidal intention the first three days of inpatient stay measured with the 10 item self-rating VAS-scale administered at discharge from the acute department. |  | Up 4 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Emergency services, psychiatric, Psychomotor agitation, Suicide, Violence
Screening for Bleeding Disorders in Children

Study Overview
=================
Brief Summary
-----------------
The investigators try to improve the screening of bleeding disorders in children by identifying symptoms, laboratory abnormalities and clinical scores discriminating patients congenital bleeding disorders in order to create a simple screening algorithm applicable in pediatrics, aiming for use in pre-anesthetic consultation and in consultation by pediatricians and general practitioners.

Detailed Description
-----------------
Objective : To determine simple clinical and biological factors that can improve the screening of hemostatic diseases at risk of hemorrhage in children. Method: Retrospective inclusion of all patients <18 years referred to the CRTH in pediatric consultation for the reason of exploration of a hemorrhagic syndrome or exploration of an anomaly in the hemostasis assessment. Data collected (by collection in the medical file): Patient data: Age, sex, personal and family history of hemorrhagic disease Clinical data: hemorrhagic symptomatology (epistaxis, gingivorrhagia, etc.) Biological data: PT, TCK, factor assay, platelet function Medical data: complete diagnosis if diagnosis of hemorrhagic disease Scores: HEMOSTOP, PBQ, ISTH, TOSETTO score Analyzes: calculation of the Odd Ratio, AUC, Se, Sp, VPP, VPN for different clinical / biological factors and each score.

Official Title
-----------------
Screening for Bleeding Disorders in Children: Evaluation of the Elements of the Interrogation, the Screening Workup and the Clinical Scores

Conditions
-----------------
Bleeding Disorder

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: referred by their general practitioner or another caring physician for evaluation of bleeding symptoms abnormal laboratory test results or family study the patient being the first-degree relative of a patient with a known bleeding disorder. Exclusion criteria: - older than 18 years old.

Ages Eligible for Study
-----------------
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Observe the correlation between the data of the interrogation | Observe the correlation between the data of the interrogation, the clinical examination and the clinical history and the demonstration of a confirm congenital bleeding disorder. | 1 day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
von Willebrand disease, hemophilia A and B, other coagulant factor deficiencies
Proximal Pole Fractures of the Scaphoid

Study Overview
=================
Brief Summary
-----------------
Aim: The aim of this study is to analyze the clinical and radiological outcomes of patients with a proximal pole fracture of the scaphoid Primary null hypothesis: There are no factors associated with nonunion of a proximal pole fracture of the scaphoid. Secondary null hypothesis: Patients with an acute proximal pole fracture of the scaphoid have QuickDASH (Disabilities of the Arm, Shoulder, and Hand) scores at or above the population norm (a score of 13 in the Norway and 10.9 in the United States), 2 to 6 months after injury.

Official Title
-----------------
A Prospective Study of Proximal Pole Fractures of the Scaphoid

Conditions
-----------------
Proximal Pole Fractures of the Scaphoid

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 18 years or greater Proximal pole fracture of the scaphoid on computed tomography scans made in the planes defined by the long axis of the scaphoid. The proximal pole will be defined as the proximal fifth of the scaphoid, excluding small scapholunate ligament avulsion fractures. Interval between injury and diagnosis of less than 2 weeks. English or Spanish fluency and literacy Exclusion Criteria: Pregnant women Inability to complete enrollment forms due to any mental status or language problems (e.g. dementia, head injury, overall illness). Patients with other fractures or injuries

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Proximal Pole Fracture of the Scaphoid<br>QuickDASH 6 months after injury CT scan 6 months after injury | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disability measured using QuickDASH |  | 6 months | 
| Nonunion of Fracture | The nonunion of the fracture will be measured using CT imaging | 6 months |
Computerized Psychoeducation for Anxiety Sensitivity

Study Overview
=================
Brief Summary
-----------------
This investigation examines the efficacy of a 35 minute computerized psychoeducation protocol in the reduction of elevated anxiety sensitivity cognitive concerns, a risk factor for the development and maintenance of various forms of psychopathology.

Conditions
-----------------
Anxiety Sensitivity

Intervention / Treatment
-----------------
* Behavioral: CAST psychoeducation
* Behavioral: PHET


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Elevated Anxiety Sensitivity Cognitive Concerns and indicated by the anxiety sensitivity index-3 Exclusion Criteria: History of epilepsy or seizures

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Psychoeducation<br>The program was designed to dispel exaggerated thoughts surrounding the danger of the experience of anxiety symptoms, specifically focusing on fears regarding feelings of cognitive dyscontrol. The psychoeducation portion contains video animation and audio narration throughout, as well as some interactive features . Participants are provided with corrective information about the experience of anxiety-related sensations, with a particular focus on dispelling myths commonly held by individuals with high anxiety sensitivity cognitive concerns . Participants are taught that anxiety-related sensations are not dangerous and that they may have developed a conditioned fear to these symptoms of arousal. | Behavioral: CAST psychoeducation<br> <br> |
| Placebo Comparator: Health and Wellness<br>The controlled condition consisted Physical Health Education Training (PHET), a computerized presentation which focuses on information on general healthy living. The PHET program contains information on nutrition, alcohol, water consumption, exercise, sexual health, hygiene, stress management, life organization, social support, positive outlook, and sleep. | Behavioral: PHET<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anxiety Sensitivity Index-3 | Measure of anxiety sensitivity | 10 minutes post intervention |
Assessment and Rehabilitation of Cognitive Impairments in Pediatric Survivors of Cancer

Study Overview
=================
Brief Summary
-----------------
This research involves assessment of cognitive outcome in childhood cancer as well as evaluation of a cognitive rehabilitation program for improving learning and problem solving difficulties in children with cancer.

Detailed Description
-----------------
The purpose of this study is to help determine specific cognitive-behavioral and neurobiologic impairments associated with chemotherapy treatments in children with cancer and to assess the efficacy of a cognitive intervention program for improving cognitive impairments in these children.

Official Title
-----------------
Assessment and Rehabilitation of Cognitive Impairments in Pediatric Survivors of Cancer

Conditions
-----------------
Neoplasms

Participation Criteria
=================
Eligibility Criteria
-----------------
INCLUSION Everyone: At least 9 years of age and less than 17 years Patients Diagnosis of brain tumor or acute lymphocytic leukemia (ALL) Completed all anti-cancer treatment(s) including chemotherapy, radiation and/or surgery Control group Typical for age EXCLUSION Everyone: Non-English speaking (translated cognitive testing and MRI assessments unavailable) MRI contraindication, including but not limited to orthodontia, metal implants, and/or pacemaker Major sensory deficit disorders, including but not limited to blindness or deafness Patients Shunt placement Received bone marrow transplant History of neurologic, psychiatric, developmental or major medical condition (eg, diabetes) NOT related to cancer Participation in any concurrent cognitive rehabilitation study Control group History of neurologic, psychiatric, developmental or major medical condition (eg, diabetes)

Ages Eligible for Study
-----------------
Minimum Age: 9 Years
Maximum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cancer patients<br>Children with cancer aged 8 to 16 years | |
| Control (non-cancer)<br>Normal children aged 8 to 16 years, age- and gender-matched to the cancer cohort | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Performance on neuropsychological testing and brain activation patterns measured by functional MRI |  | 8 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Carcinomas, Squamous Cel, Adenocarcinoma, Acute Lymphocytic Leukemia
Persistent Pain After Reconstruction Following Mastectomy

Study Overview
=================
Brief Summary
-----------------
A cross sectional study to determine the prevalence of persistent pain after reconstructive surgery after mastectomy for breast cancer, with a comparative analysis of a cohort treated with mastectomy without reconstruction.

Detailed Description
-----------------
The aim of the study is to determine if reconstruction of the breast after mastectomy increases the risk of reporting persistent pain 2-3 years after surgery.

Official Title
-----------------
Persistent Pain After Reconstruction Following Mastectomy

Conditions
-----------------
Breast Cancer, Chronic Pain

Intervention / Treatment
-----------------
* Procedure: Reconstruction


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with unilateral primary breast cancer aged 18-70 years Exclusion Criteria: recurrent cancer other malignancy emigration non-standardized treatment

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Mastectomy<br>Patients treated with mastectomy without reconstruction | |
| Reconstruction<br>Patients treated with mastectomy followed by reconstruction | Procedure: Reconstruction<br>* Reconstructive surgery after mastectomy, either by expander or autologous tissue. Includes both primary and secondary reconstruction<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The risk of developing persistent if reconstructed | The risk of developing persistent if reconstructed compared to patients mastectomized without reconstruction expressed as an odds ratio. | Cross-sectional, 2-3 years after surgery for breast cancer | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of persistent pain after reconstruction after mastectomy | Self reported pain expressed as a percentage of the population of patients reconstructed with expander and autologous tissue. Pain intensity measured with a numerical rating scale 0-10, divided in mild (NRS 1-3), moderate (4-6) and severe pain (7-10). Patients regarded as having clinically relevant pain: NRS 4 or above, at least at a weekly basis. | Cross-sectional, 2-3 years after surgery for breast cancer | 
| Prevalence of sensory disturbances after reconstruction after mastectomy |  | Cross-sectional, 2-3 years after surgery for breast cancer | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pain, Neuropathic pain, Chronic pain
Relationship of Retinal and Visual Cortex Structure and Visual Acuity After Congenital Cataract Surgery

Study Overview
=================
Brief Summary
-----------------
To evaluate the influence of the visual acuity after congenital surgery on the retinal and visual cortex structure.

Detailed Description
-----------------
According to the visual acuity after congenital cataract surgery, 30 patients are divided into 3 groups.SD-OCT and MRI were used to measure the parameters of the retina and the visual cortex, to compare the differences between different groups, and to analyze the relationship between the structure of the retina and the visual cortex and visual acuity.

Official Title
-----------------
Relationship of Retinal and Visual Cortex Structure and Visual Acuity After Congenital Cataract Surgery

Conditions
-----------------
Congenital Cataract

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age of 4-60 years Congenital cataract surgery is planned The operation was successful without any complications Can cooperate well with OCT and MRI examinations Exclusion Criteria: Intraoperative and postoperative complications include glaucoma, retinal, corneal, or refractive medium diseases Behavioral, cognitive impairment Developmental delay

Ages Eligible for Study
-----------------
Minimum Age: 4 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1<br>The BCVA of eyes is greater than 0.6 | |
| Group 2<br>The BCVA of eyes is from 0.1 to 0.6 | |
| Group 3<br>The BCVA of eyes is less than 0.6 | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Macular thickness | Scan the 3.0mm diameter ETDRS ring area in the macular area with SD-OCT. | 2021.12.30 | 
| Subfoveal choroidal thickness | Scan the Subfoveal choroid in enhanced scan mode with SD-OCT. | 2021.12.30 | 
| Retinal nerve fiber layer thickness | Scan concentric circles with a length of 3.4mm and a diameter ranging from 2.5mm to 4.0mm in 12 directions centered on the optic disc with SD-OCT. | 2021.12.30 | 
| The volume of the lateral geniculate body | Measure the volume of the lateral geniculate body by T1 phase scan of MRI | 2021.12.30 | 
| The volume of the brodmann 17,18,19 area | Masure the volume of the brodmann 17,18,19 area by T1 phase scan of MRI | 2021.12.30 | 
| The FA of the white matter fiber bundle | Measure the Fraction Anisotropy of the white matter fiber bundle related to visual signal transduction by DWI scan of MRI | 2021.12.30 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
amblyopia, SD-OCT, visual acuity, retinal structure, visual cortex structure, MRI