Evaluation of Aortic Aneurysms With Focus on Wall Stress and Wall Rupture Risk

Study Overview
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Brief Summary
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Retrospective study to evaluate the impact of computational wall stress analysis based on computed tomography (CT) of ruptured and not-ruptured aortic aneurysms as an additional predictor for rupture with dedicated software.

Detailed Description
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In patients with known aortic aneurysm who received clinically indicated CT during a time period from 01/2004-12/2013 the CT data was evaluated with dedicated software, A4clinics, VASCOPS GmbH, Graz, Austria. The following parameters will be evaluated: exterior and luminal diameter, intraluminal thrombus (ILT) thickness, vessel-, luminal- and intraluminal thrombus volume, peak wall stress (PWS), peak wall rupture risk (PWRR), von Mises-stress and rupture risk-index in the ILT.

Official Title
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Evaluation of Aortic Aneurysms With Focus on Wall Stress and Wall Rupture Risk by Computational Finite Element Analysis With Dedicated Software

Conditions
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Aortic Aneurysm

Intervention / Treatment
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* Other: CT-acquisition


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical indicated CT data from patients with known aortic aneurysms. Clinical indication was: Follow up CT examination by known aortic aneurysm Patient with known aortic aneurysm with new acute clinical symptoms Patients with clinical suspicion of aortic aneurysm Exclusion Criteria: known exclusion criteria for CT examination as known allergy to iodine or contrast media known pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| asymptomatic not ruptured aneurysm<br>Patients with asymptomatic not ruptured aortic aneurysms greater than 3 cm who received a clinical indicated CT | Other: CT-acquisition<br> <br> |
| symptomatic not ruptured aneurysm<br>Patients with symptomatic aortic aneurysms greater than 3 cm who received a clinical indicated CT | Other: CT-acquisition<br> <br> |
| symptomatic ruptured aneurysm<br>Patients with symptomatic ruptured aortic aneurysms greater than 3 cm who received a clinical indicated CT | Other: CT-acquisition<br> <br> |
| patients with small aneurysms<br>Patients with small aortic aneurysms approximately 5.5 cm, ruptured and not ruptured, who received a clinical indicated CT | Other: CT-acquisition<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To calculated the rupture risk equivalent diameter (RRED) of the aortic aneurysm and rupture risk-index in the intraluminal thrombus within the aortic aneurysm. | By using the finite analysis from the CT data the peak wall stress (PWS), the peak wall rupture (PWRR) and the mises stress within the aortic aneurysm depending on the diameter and volume of the aortic aneurysm and of the intraluminal thrombus will be measured. | CT Data from 01/2004-12/2013 |