Functionality of an 8-Channel Paddle Coil for Use With MRI

Study Overview
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Brief Summary
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The objective of this study is to determine the functionality of an eight-channel paddle coil system which is to be used in future MRI studies.

Detailed Description
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Prostate cancer is the most common malignancy among men and the second leading cause of cancer death in men. Currently, MRI is the best imaging modality for both detecting prostate cancer and determining the presence of extra-prostatic extension. Multiparametric Magnetic Resonance, combining T2-weighted, diffusion-weighted and dynamic contrast enhanced imaging (DCE-MRI) is recommended as the minimum acceptable standard for prostate MRI examination. However, MPMRI still lacks diagnostic accuracy in the transition zone, where distinguishing cancer from proliferative nodules has proven difficult. DCE-MRI techniques evaluate the time course of signal intensities after administration of a contrast medium and have been used to successfully differentiate benign from malignant tumours, particularly in breast and prostate cancer. Unfortunately, current DCE approaches have high false-positive rates and are limited in distinguishing prostatitis and vascularized BPH nodules from cancer in active surveillance studies. Future studies that employ spectroscopic MR imaging of the prostate after administration of Hyperpolarized (13C) Pyruvate Injection, are expected to provide a robust, non-invasive method to assist in detecting and characterizing prostate cancer. The objective of this study is to determine the functionality of an eight-channel paddle coil system which is to be used in future Hyperpolarized (13C) Pyruvate Injection studies.

Official Title
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Study to Evaluate the Functionality of an Eight-Channel Paddle Coil System Using MRI

Conditions
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Prostate in Healthy Males

Intervention / Treatment
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* Device: 8-channel paddle coil


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy male volunteers between 18 and 80 years of age Exclusion Criteria: Any contra-indication for MR imaging (such as pacemakers, surgical implants, foreign metal objects in the body)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Functionality of 8-channel paddle coil system<br> | Device: 8-channel paddle coil<br>* MRI Coil<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ability of Coil to produce MRI images | functional with adequate SNR functional with non-adequate SNR non-functional | 1 hour | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Paddle, Eight, Channel, Coil, MRI, Prostate, Healthy Male