Endometrial Local Injury and Implantation Failure

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the influence of endometrial biopsy on increasing implantation rate in patients with recurrent implantation failures, 93 women with at least two implantation failures were evaluated. In case group endometrial biopsy was obtained from 48 patients in the luteal phase of previous cycle and implantation and clinical pregnancy rate were compared with 45 patients in control group. The results suggest that in vitro fertilization or intracytoplasmic sperm injection after endometrial biopsy increase pregnancy outcome.

Detailed Description
-----------------
In a randomized control trial study, 93 women with at least two implantation failures were evaluated. In case group endometrial biopsy was obtained from 48 patients in the luteal phase of previous cycle and implantation and clinical pregnancy rate were compared with 45 patients in control group. The implantation rate was determined as 10.9% in biopsy group compared with 3.38% in controls. Clinical pregnancy rate was significantly higher in case group than controls (27.1% and 8.9% respectively

Official Title
-----------------
Endometrial Local Injury Improves the Pregnancy Rate Among Recurrent Implantation Failure Patients Undergoing IVF/ICSI

Conditions
-----------------
Infertility

Intervention / Treatment
-----------------
* Procedure: Endometrial biopsy
* Procedure: Endometrial Biopsy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: women with recurrent implantation failure which was defined as 2-6 cycles unsuccessful of IVF-ET in which more than 10 high grade embryo were transferred Exclusion Criteria: age over than 40 years old poor responders to ovarian stimulation

Ages Eligible for Study
-----------------
Minimum Age: 15 Years
Maximum Age: 39 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Biopsy catheter<br>Biopsy catheter (Pipelle de Cornier, Prodimed, Neuilly-en-Thelle, France | Procedure: Endometrial biopsy<br>* Endometrial biopsy was done at luteal phase on the day 21-26 of spontaneous menstrual cycles, when GnRH agonist uses begun. Endometrial samples were taken by a biopsy catheter<br>* Other names: biopsy catheter (Pipelle de Cornier, Prodimed, France;Procedure: Endometrial Biopsy<br>* Biopsy catheter<br>* Other names: Pipelle de Cornier, Prodimed, Neuilly-en-Thelle, France;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Implantation Rate,Chemical pregnancy rate, Clinical pregnancy rate |  | One year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Endometrial biopsy, IVF/ICSI, Pregnancy outcome, Recurrent implantation failure