linjc16/ctgov huggingface dataset:
Effect of Sleep Deprivation on Sensory Integration of Balance, Fall Risk and Postural Stability

Study Overview
=================
Brief Summary
-----------------
Sleepiness caused by sleep deprivation may increase the risk of injuries and damages during physical activity. Individual data so far indicates worsening of postural stability and control with females exhibiting better static postural stability regardless of sleeping conditions in comparison to men. However, the literature is deficient in terms of postural stability conditions with eyes open and eyes closed states, as well as fall risk and sensory integration of balance.

Official Title
-----------------
Effect of Sleep Deprivation on Sensory Integration of Balance, Fall Risk and Postural Stability

Conditions
-----------------
Sleep Deprivation

Intervention / Treatment
-----------------
* Behavioral: Sleep Deprivation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 19 to 24 Healthy young adults from Rawalpindi/Islamabad. Both males and females Participants should have normal sleep patterns without any signs or symptoms of insomnia or hypersomnia. Persons without any sleep disorders. Persons without any neurological disease. Exclusion Criteria: Persons with sleep disorders such as hypersomnia, insomnia, parasomnia etc. Elderly population. Persons with any sort of neurological deficits. COVID positive and those with any suspected signs and symptoms of COVID-19. Alcoholics Pregnant females A participant with the history of or active diagnosed conditions of any of the following, which renders individual's performance will be excluded: Neurological. Musculoskeletal. Cardiopulmonary. Any congenital disorder or limb deformities.

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 24 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sleep deprivation<br>Participant data will be acquired before and after 24 hours of sleep deprivation. | Behavioral: Sleep Deprivation<br>* The participants will stay awake for 24 hours.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postural Stability Index | Postural stability Index will be measured via Biodex Balance System. A lower score represents better postural stability. | 24 hours | 
| Fall Risk Score | Fall Risk Score will be measured via Biodex Balance System. A lower score represents better postural stability. | 24 hours | 
| Clinical Test of Sensory Integration and Balance | Clinical Test of Sensory Integration and Balance will be measured via Biodex Balance System. A lower score represents better postural stability. | 24 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
sleep deprivation
Validation of Completion of Items 18, 19 and 22 of the Motor Function Measure (MFM) on a Digital Tablet

Study Overview
=================
Brief Summary
-----------------
Motor Function Measure (MFM) is a validated tool assessing the motor function of neuromuscular patients constituted of 32 items. Despite standardized Motor Function Measure (MFM) training sessions, there is still an inter-individual variability in the items' scoring procedure, depending for example on the subjectivity of the therapist. Among the 32 items of the MFM, 3 currently require the use of a paper, and could be automated by using a digital tablet. It is the item 18 where the patient traces the edge of a Compact Disc, item 19 requiring to draw loops inside a frame and item 22 requiring to place a finger on each standardized cases. The reproducibility of these 3 items could be improved with the use of a digital tablet and the development of a software allowing to computerize the scoring procedure. The second interest is to implement directly the MFM data in the MFM base. The hypothesis is that the difference of scoring of these 3 items between digital tablet versus paper completion is enough low to use indifferently each completion in patients with a neuromuscular disease.

Official Title
-----------------
Validation of Completion of Items 18, 19 and 22 of the Motor Function Measure (MFM) on a Digital Tablet

Conditions
-----------------
Neuromuscular Diseases

Intervention / Treatment
-----------------
* Other: Items completion


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with a labelled neuromuscular disease Patients with Motor Function Measure in one of the participating services during their usual follow-up Patients who received the information and did not object to participating in the study or their parents for the children Exclusion Criteria: Patients passing their Motor Function Measure as part of another research protocol

Ages Eligible for Study
-----------------
Minimum Age: 5 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Items completion|Patients will complete his Motor Function Measure in the usual way, except items 18, 19 and 22 which will be completed twice: once using conventional material and once on a digital tablet. The order of completion between conventional material or digital tablet will be allocate randomly.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison scoring between items completed using conventional material or on a digital tablet. | The comparison of scores between usual test (paper) versus digital tablet test, for the item 18, 19 and 22 of the Motor Function Measure. | 1 day |
FMRI Assessment After Radiofrequency in Trigeminal Neuralgia

Study Overview
=================
Brief Summary
-----------------
To investigate the brain activations related to TN, using fMRI, and to evaluate changes in these activations following the application of pulsed and thermal Radiofrequency lesioning to the gasserien ganglion.

Official Title
-----------------
Brain Activity Assessment by Functional MRI Before, After Radiofrequency of Gasserian Ganglia in Patient With Trigeminal Neuralgia

Conditions
-----------------
Trigeminal Neuralgia, Pain, Neuropathic

Intervention / Treatment
-----------------
* Procedure: pulsed Radiofrequency
* Procedure: thermal Radiofrequency


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 20 - 65 years Primary trigeminal neuralgia Maxillary and/or mandibular affection only Failure of medical treatment Exclusion Criteria: 2ry trigeminal neuralgia Recurrent trigeminal neuralgia Ophthalmic branch affection Contraindication for intervention (sepsis, coagulopathy, infection at entery point, local anesthetic allergy,…) Pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: pulsed radiofrequency<br>sensory stimulation will be carried out at 50 Hz. The definitive position of the electrode will be verified by inducing paresthesia with sensory stimulation between 0.1-0.3 V in the affected painful area, then pulsed radiofrequency will be applied for 10 patients for 10 mins | Procedure: pulsed Radiofrequency<br>* sensory stimulation will be carried out at 50 Hz. The definitive position of the electrode will be verified by inducing paresthesia with sensory stimulation between 0.1-0.3 V in the affected painful area, then pulsed radiofrequency will be applied for 10 patients for 10 mins<br>|
| Active Comparator: thermal Radiofrequency<br>sensory stimulation will be carried out at 50 Hz. The definitive position of the electrode will be verified by inducing paresthesia with sensory stimulation between 0.1-0.3 V in the affected painful area, then Thermal lesion will be applied for 10 patients for 2 cycles of 90 seconds | Procedure: thermal Radiofrequency<br>* sensory stimulation will be carried out at 50 Hz. The definitive position of the electrode will be verified by inducing paresthesia with sensory stimulation between 0.1-0.3 V in the affected painful area, then Thermal lesion will be applied for 10 patients for 2 cycles of 90 seconds<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pain alleviation | pain assessment by functional MRI | 1 month |
Deep Learning-based Classification and Prediction of Radiation Dermatitis in Head and Neck Patients

Study Overview
=================
Brief Summary
-----------------
to develop a deep learning-based model to grade the severity of radiation dermatitis (RD) and predict the severity of radiation dermatitis in patients with head and neck cancer undergoing radiotherapy, so as to provide support for doctors' diagnosis and prediction.

Detailed Description
-----------------
Image acquisition The images of the neck area were collected from the enrolled patients one week before and every week during radiotherapy. The photographs were taken from three angles (front, left and right oblique) of the neck area. Grading evaluation Each image was individually graded by three experienced radiotherapy experts according to the RD criteria of RTOG Data analysis Construct a dermatitis grading model basing on deep learning. Evaluate the performance of model using accuracy, precision, recall, F1-measure, dice value.

Official Title
-----------------
Deep Learning-based Classification and Prediction of Radiation Dermatitis in Head and Neck

Conditions
-----------------
Radiation Dermatitis, Head and Neck Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age ≥ 18 years old. Histologically or cytologically confirmed head and neck carcinoma confirmed by pathology. Receive radical radiotherapy including neck area Informed consent. Exclusion Criteria: unable to cooperate with image acquisition

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Accuracy | Evaluate the rate of deep learning based rating model in accordance with experts' assessment. | July 1, 2022 to June 30, 2025 | 
| Precision | The proportion of positive samples in the positive prediction result | July 1, 2022 to June 30, 2025 | 
| Recall | The proportion of positive samples that were predicted to be positive | July 1, 2022 to June 30, 2025 | 
| F1-measure | The harmonic average of precision and recall | July 1, 2022 to June 30, 2025 | 
| ROC curve |  | July 1, 2022 to June 30, 2025 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| dice value | Ratio of overlap and distance between artificial and automatic neck segmentation regions | July 1, 2022 to June 30, 2025 |
Development of a Model to Predict the Risk of Venous Thromboembolic Events in Patients With Metastatic Bronchopulmonary Cancer

Study Overview
=================
Brief Summary
-----------------
Venous thrombo-embolism (VTE) is a frequent and serious complication of cancer. However, predictive tools for VTE in cancer patients is lacking. In patients with metastatic broncho-pulmonarycancer, biochemical characteristics might help to identify patients at high risk for VTE. The aim of this study is to derive a predictive score combining clinical and biochemical variable that predict VTE in metastatic broncho-pulmonary cancer.

Detailed Description
-----------------
Venous thrombo-embolism (VTE) is a frequent and serious complication of cancer. However, predictive tools for VTE in cancer patients is lacking. In patients with metastatic broncho-pulmonarycancer, biochemical characteristics might help to identify patients at high risk for VTE, particularly in adenocarcinoma. The aim of this study is to derive a predictive score combining clinical and biochemical variable that predict VTE in metastatic broncho-pulmonary cancer.

Official Title
-----------------
Développement d'un modèle prédictif du Risque de Survenue d'évènements Thromboemboliques Veineux Chez Les Patients Atteints de Cancer Broncho-pulmonaire métastatique

Conditions
-----------------
Metastatic Bronchopulmonary Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: metastatic broncho-pulmonary cancer age ≥18 years who are eligible for chemotherapy non opposition obtained Exclusion Criteria: age <18 years pregnancy, breast feeding VTE in the past 6 months or at the time of cancer diagnosis surgery in the past 3 months refusal to participate

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| venous thromboembolism at 12 months | objectively diagnosed VTE based on validated diagnostic tests | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| overall survival | overall survival | one year | 
| survival without progression | survival without progression | one year | 
| VTE at 6 months | VTE at 6 months | 6 months |
Adolescent Normative Sport Movement Analysis

Study Overview
=================
Brief Summary
-----------------
The objective of this study is to collect baseline data from a normative population of adolescents who participate in organized land-based sports, that gender and age matches some of the population of patients expected to be treated at Mary Bridge Children's Therapy Services, MultiCare affiliated therapy centers, and Mary Bridge Specialty Clinics who will be seen in the Research and Movement Lab. This project will recruit 40 patients between the ages of 13-25 years old. Non-invasive measurements of movement patterns will be collected during common sport-related activities over a single data collection session.

Official Title
-----------------
Adolescent Normative Sport Movement Analysis

Conditions
-----------------
Lower Extremity Problem, Musculoskeletal Injury

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age between 13-25 years. Participate in a land-based organized sport in the last 1 year with intent on continued participation in the next year. Perform sport-related activities such as running/sprinting, cutting maneuvers, and jumping. Tolerate adhesive markers placed on skin and clothing. Willing and interested in participating. Exclusion Criteria: Neuromuscular disorders such as cerebral palsy, muscular dystrophy, myotonic dystrophy, spinal muscular atrophy, peripheral neuropathy, or other generalized muscle and/or nerve issues. Currently undergoing treatment or receiving medication that affects movement. Requires ankle/knee bracing to safely perform running, sprinting, jumping activities. History of orthopedic surgery to lower limbs. In last 6 months: receiving/seeking medical treatment for injury. Difficulty performing sport-related activities. Pain that has inhibited participation in sports/daily activities in the last 3 months.

Ages Eligible for Study
-----------------
Minimum Age: 13 Years
Maximum Age: 25 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Observation-based movement analyses | The purpose of the sports normative data collection is to develop a baseline database from a normative population of adolescents who participate in organized land-based sports. Observation-based analyses are performed with a trained practitioner identifying events (e.g. max knee flexion) and general joint position (e.g. knee valgus) through visual observation, or with the aid of video. This project will recruit 40 patients between the ages of 13-25 years old. Non-invasive measurements of movement patterns will be collected during common sport-related activities over a single data collection session. | Baseline |
Open/Aftercare Treatment for Participants Diagnosed With Obsessive Compulsive Disorder

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to provide participants diagnosed with obsessive compulsive disorder (OCD) and completed one of the active study protocols at the Rodriguez Lab, with open/aftercare treatment.

Detailed Description
-----------------
After completing one of the active clinical studies participants have the option to enroll in this protocol that offers open treatment. The goal is to compare two forms of current standard treatments, psychotherapy vs pharmacotherapy.

Official Title
-----------------
Open/Aftercare Treatment for Participants Diagnosed With Obsessive Compulsive Disorder

Conditions
-----------------
OCD

Intervention / Treatment
-----------------
* Behavioral: Psychotherapy
* Other: Pharmacotherapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Ability to speak and understand English Capacity to consent (e.g. as determined by assessing the patient's understanding of the risks, benefits, and procedures of the study) Completed an active study protocol at the Rodriguez Lab at Stanford University Exclusion Criteria: Children younger than 18 Active suicidality

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Interventional Model Description: Participants will choose to enter the psychotherapy or pharmacotherapy arm.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Psychotherapy<br>Participants will receive evidenced based psychotherapy by a trained psychologist | Behavioral: Psychotherapy<br>* Evidenced based psychotherapy by a trained psychologist<br>|
| Active Comparator: Pharmacotherapy<br>Participants will receive pharmacotherapy by a psychiatrist | Other: Pharmacotherapy<br>* Pharmacotherapy by a psychiatrist<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improvement in the severity of OCD symptoms as measured by the Yale-Brown Obsessive Compulsive Scale (YBOCS) | Improvement in OCD severity is measured by the YBOCS (Yale Brown Obsessive-Compulsive Scale), a gold standard measure of obsessions and compulsions. For the YBOCS the minimum units are 0 and Maximum units on the total scale are 40. The higher the number on the YBOCS, the more severe the symptoms. Response is defined as at least a 35% reduction on the YBOCS. | Up to 14 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
treatment, psychotherapy, pharmacotherapy
Ascending Dose Tolerability/Safety of SLV308 for the Treatment of Parkinson's Disease

Study Overview
=================
Brief Summary
-----------------
This study is a multicenter, randomized, double-blind, placebo controlled, parallel group study of a seven-week ascending dose period of SLV308 adjunctive to L-dopa treatment in patients with advanced stage Parkinson's disease (PD) and dose-dependent motor fluctuations. Patients (outpatients) will be randomized to one of three different treatment arms.

Official Title
-----------------
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Ascending Dose, Parallel Group Study Exploring Effects of SLV308 up to 42 mg/Day Administered as an Adjunctive Therapy to L-Dopa in Patients With Advanced Stage Parkinson's Disease

Conditions
-----------------
Parkinson's Disease

Intervention / Treatment
-----------------
* Drug: SLV308


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients who have signed an informed consent; diagnosis of idiopathic PD. Presence of recognizable on and off stages Minimum hours of off time per day of 2.5 hours Able to keep diaries. Exclusion Criteria: Unclear diagnosis or a suspicion of other parkinsonian syndromes Have undergone surgical treatment for PD History of non-response to L-dopa.

Ages Eligible for Study
-----------------
Minimum Age: 30 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: SLV308|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Parkinson's disease, adjunctive to L-dopa therapy, Advanced stage Parkinson's disease