Lower Extremity Muscle and Function in the Elderly: Study 2

Study Overview
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Brief Summary
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This research study is looking to compare the effects of two uniquely different power training interventions (high force, lower velocity versus low force, high velocity) on changes in mobility status among older individuals at risk for mobility disability.

Official Title
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Lower Extremity Muscle and Function in the Elderly: Study 2

Conditions
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Mobility Limitation

Intervention / Treatment
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* Behavioral: High velocity low force Power Training
* Behavioral: Low velocity high force Power Training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male and Female 70-85 yrs Community dwelling Short Performance Battery Score >9 BMI range 19-32 kg/m2 Willingness to be randomized and come the laboratory for 20 weeks. Exclusion Criteria: Acute or Terminal Illness MI in previous 6 months, symptomatic coronary artery disease or congestive heart failure. Upper or Lower extremity fracture in previous 6 months Uncontrolled hypertension (150/90mmHg) Neuromuscular diseases and drugs that affect neuromuscular function Hormone replacement therapy Participation in any regular endurance or resistance training exercise during previous 3 months

Ages Eligible for Study
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Minimum Age: 70 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: High velocity low force Power Training<br>Lower Extremity high velocity power training performed at lower external resistance (40% of the 1 repetition maximum muscle strength). Leg and knee extension exercises were performed twice per week (3 sets of each exercise consisting of 10 repetitions). | Behavioral: High velocity low force Power Training<br>* Lower Extremity high velocity power training performed at lower external resistance (40% of the 1 repetition maximum muscle strength). Leg and knee extension exercises were performed twice per week (3 sets of each exercise consisting of 10 repetitions).<br>|
| Experimental: Low velocity high force Power Training<br>Lower extremity low velocity power training performed at high external resistance (70% of the 1 repetition maximum muscle strength). Leg and knee extension exercises were performed twice per week (3 sets of each exercise consisting of 10 repetitions). | Behavioral: Low velocity high force Power Training<br>* Lower extremity low velocity power training performed at high external resistance (70% of the 1 repetition maximum muscle strength). Leg and knee extension exercises were performed twice per week (3 sets of each exercise consisting of 10 repetitions).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Leg Extensor Muscle Power | Leg extensor muscle power measured on pneumatic strength testing equipment at a external force consistent with 70% of the participant maximum leg extensor strength. | Change from baseline to Week 16 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Resistance Exercise, Physical Activity, Mobility disability, Physical function, Muscle Strength, Older Adults, Mobility-Limited, Peak power and strength