Integrative Study of Vestibular Pathology

Study Overview
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Brief Summary
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Exploratory posturological, neurosensory, cognitive, emotional, personality and general evaluations (quality of life). The investigators will characterize a sensory profile quantified by one or more scores from a multi-parameter baysian approach. Each parameter and these scores will be correlated to the type of vestibular damage and its recovery in order to establish diagnostic, prognostic and therapeutic follow-up markers.

Detailed Description
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This is an exploratory neurophysiological work that aims to identify diagnostic, prognostic and therapeutic markers in vestibular pathology. Theinvestigators wish to characterize the neurosensory profile of individuals using new exploration paradigms provided by a new posturology platform coupled with virtual reality scenarios and by proposing a complete transversal approach in terms of evaluation of the subjects: personality, cognition, emotion including the depressive state, sensory strategy, general data. Baysian statistical approaches and linear mixed model will be used to determine markers of sensory profile correlated to the vestibular damage for diagnostic, prognostic and therapeutic follow-up. The investigators aim to be able to better characterize the cognitive-emotional and sensory deficits expressed by the vertiginous and unstable patients, to integrate it into the evaluation of the vestibular pathology, to use these markers to better discriminate the underlying physiopathological mechanisms, and to improve at the same time the diagnosis of the functional attack and the rehabilitation follow-up of the patients.

Official Title
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Integrative Study of Vestibular Pathology With Analysis of Postural, Neurosensory, and Cognitive Disorders: Search for New Markers on the Causes and Consequences of Vertigo

Conditions
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Dizziness; Syndrome

Intervention / Treatment
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* Other: Neurosensory


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male or female patient (18-80 years old) Patient with an acute or chronic vestibular pathology according to ENT diagnostic criteria Exclusion Criteria: Subjects under 18 years of age Pregnant or breastfeeding women, Persons in an emergency situation or unable to give their consent, including adults under guardianship Person under legal protection Patient presenting a vertigo or postural disorders of non vestibular etiology Persons deprived of liberty, minors, protected adults, Patients with an intercurrent neurological pathology including cerebellar pathology Inclusion of the subject in another interventional research protocol with pharmacological aim during the present study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Interventional Model Description: a group of patient suffering from vestibular pathology will be investigated regardless the etiology of the vertigo or dizziness
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: patient<br>One cohort of patients | Other: Neurosensory<br>* Physiological and neurophysiological investigations<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Posture | postural measurement | through follow-up, an average of 6 months | 
| Cognition | Spatial cognitive performance in a calibrated virtual radial maze | through follow-up, an average of 6 months | 
| Personnality characteristic | Evaluation of the BIg Five inventory test | through follow-up, an average of 6 months | 
| Sleep | Quantitative sleep recording | through follow-up, an average of 6 months | 
| Emotion | Anxiety measurement via questionnary | through follow-up, an average of 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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vertigo, cognition, emotion, physiotherapist, posture, vestibular system, balance