Network Connectivity and Temporal Processing in Adolescents Who Stutter

Study Overview
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Brief Summary
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The specific purpose of this clinical trial is to compare performance on rhythm perception and production tasks between children who stutter and children who do not stutter. The overall project also aims to investigate how performance on rhythm tasks may be related to brain activity (non-clinical trial).

Detailed Description
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Participants in the clinical trial portion of this study will complete rhythm discrimination and finger tapping experiments once a year for 3 years. The study team will compare performance between groups. Participants will also participate in the non-trial portion of the project that includes having magnetic resonance imaging (MRI) each year for 3 years.

Official Title
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Subcortical Network Connectivity and Temporal Processing in Children With Persistent and Recovered Stuttering

Conditions
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Stuttering, Childhood, Stuttering

Intervention / Treatment
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* Behavioral: Rhythm discrimination


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria Children who stutter: English as primary language Current or past stuttering diagnosis Inclusion Criteria Children who do not stutter: English as primary language Exclusion Criteria Children who stutter: Diagnosed/under treatment for any neurological or psychiatric conditions Head trauma with loss of consciousness Major medical illness Hearing loss- Language/motor delay (below -2 standard deviations on standardized assessments) Face, motor, or reflex abnormalities Exclusion Criteria Children who do not stutter: Personal or family history of stuttering Diagnosed/under treatment for any neurological or psychiatric conditions Head trauma with loss of consciousness Major medical illness Hearing loss Language/motor delay (below -2 standard deviations on standardized assessments Face, motor, or reflex abnormalities

Ages Eligible for Study
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Minimum Age: 9 Years
Maximum Age: 13 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Children who stutter<br>Children who stutter | Behavioral: Rhythm discrimination<br>* Participants will complete a rhythm discrimination task once per year for 3 years.<br>|
| Experimental: Children who do not stutter<br>Children who do not stutter | Behavioral: Rhythm discrimination<br>* Participants will complete a rhythm discrimination task once per year for 3 years.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rhythm discrimination (d') | Performance on the rhythm discrimination task will be assessed using a signal detection analysis to distinguish between participants' ability to discriminate same and different rhythms from any general tendency to respond same or different. Hit rates (HRs) and false alarm rates (FARs) will be obtained to calculate d' (a measure of sensitivity; determined by z(HR) - z(FAR)). | Year 1 | 
| Rhythm discrimination (d') | Performance on the rhythm discrimination task will be assessed using a signal detection analysis to distinguish between participants' ability to discriminate same and different rhythms from any general tendency to respond same or different. Hit rates (HRs) and false alarm rates (FARs) will be obtained to calculate d' (a measure of sensitivity; determined by z(HR) - z(FAR)). | Year 2 | 
| Rhythm discrimination (d') | Performance on the rhythm discrimination task will be assessed using a signal detection analysis to distinguish between participants' ability to discriminate same and different rhythms from any general tendency to respond same or different. Hit rates (HRs) and false alarm rates (FARs) will be obtained to calculate d' (a measure of sensitivity; determined by z(HR) - z(FAR)). | Year 3 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Timing, Rhythm, Temporal processing, Healthy children, Speech disorders