Xenon-enhanced Ventilation CT-guided Radiotherapy for Lung Cancer Treatment

Study Overview
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Brief Summary
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The investigators aim to use xenon-enhanced ventilation computed tomography (CT) to design personalized functional lung avoidance radiotherapy for lung cancer patients who are scheduled to receive lung radiation therapy. The investigators' goal is to optimally protect the lung function of the patients and reduce the incidence of radiation pneumonitis.

Detailed Description
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There has been an increase in the application of radiation therapy in the treatment of lung tumors; however, the associated side effect, called radiation pneumonitis, can significantly reduce lung function and the quality of life of patients, eventually leading to fatal consequences. The investigators aim to use xenon-enhanced ventilation computed tomography (CT) to design personalized functional lung avoidance radiotherapy for lung cancer patients who are scheduled to receive lung radiation therapy. The investigators' goal is to optimally protect the lung function of the patients and reduce the incidence of radiation pneumonitis.

Official Title
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Xenon-enhanced Ventilation CT-guided Radiotherapy for Lung Cancer Treatment: Functional Protection of the Lung and Prevention of Radiation Pneumonitis

Conditions
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Lung Cancer, Radiation Therapy Complication

Intervention / Treatment
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* Radiation: Xenon-enhanced Ventilation CT-guided Radiotherapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged 20-80 years, with lung cancer receiving thoracic radiotherapy in NTUH, from February 2020 to December 2024. Exclusion Criteria: The age is less than 20 years old or older than 80 years old. Unstable clinical condition, unable to maintain apnea for 15 second, and history of prior adverse reaction to xenon. Renal insufficiency patients. Claustrophobia Those who are pregnant.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Xenon-enhanced Ventilation CT-guided Radiotherapy<br>Patients will be receiving Xenon-enhanced Ventilation CT-guided Radiotherapy for functional lung avoidance. The doses for the tumors, lungs, and organs at risk will be examined and evaluated. | Radiation: Xenon-enhanced Ventilation CT-guided Radiotherapy<br>* Xenon-enhanced Ventilation CT-guided Radiotherapy for functional protection of the lung<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of radiation pneumonia | Incidence of radiation pneumonia | Within 1 year of radiation therapy | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Xenon-enhanced ventilation CT, lung cancer, Radiation Therapy