A Rehabilitation Program to Increase Balance and Mobility in Ataxia of Charlevoix-Saguenay

Study Overview
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Brief Summary
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This exploratory study used a pre-post test design. The supervised rehabilitation program was performed three times a week for 8 weeks (two sessions at a rehabilitation gym and one pool session). Outcome measures included Ottawa sitting scale, 30-Second Chair Stand test, Berg Balance Scale, 10-Meter Walk Test, 6-minute Walk Test, modified Activities-specific Balance Confidence Scale and SARA scale. 10 participants will complete the training program. They will be evaluated at baseline, at week 4 (miway) and after the program.

Official Title
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A Better Trunk and Lower Limb Control for a Better Mobility: Assessment of a Re-entrainment Program in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay

Conditions
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Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay

Intervention / Treatment
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* Other: Training program


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Genetically confirmed ARSACS diagnosis; walker (indoor walking abilities with or without walking aids); ability to walk 10 meters; ability to provide informed consent Exclusion Criteria: Having other medical diagnosis causing physical limitations

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Training program<br>8-week rehabilitation program aimed at increasing trunk and lower limb motor control on balance and walking abilities, and accomplishment of activities of daily living. | Other: Training program<br>* 8-week rehabilitation program aimed at increasing trunk and lower limb motor control on balance and walking abilities, and accomplishment of activities of daily living.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in the Scale for the assessement and rating of ataxia (SARA) | Measured with the Scale for the assessement and rating of ataxia (SARA), score range 0-40, higher score indicates higer ataxia severity | Baseline, week 4, week 8 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in walking speed | Change in the walking speed, measured with the time to walk 10 meters at comfortable and maximum speed | Baseline, week 4, week 8 | 
| Change in the number of sit-to-stand performed in 30 seconds | Number of complete sit-to-stand performed in 30 seconds without the help of arms | Baseline, week 4, week 8 | 
| Change in the balance confidence | Measured with the modified Activities-specific Balance Confidence (ABC) Scale, score range 0-100, 0 indicates no confidence and 100 is full confidence. | Baseline, week 4, week 8 | 
| Change in balance | Measured with the Berg Balance Scale, score range 0-56, a higher score indicates better balance. | Baseline, week 4, week 8 | 
| Change in sitting balance | Measured with the Ottawa sitting scale, score range 0-40, a higher score indicates a better outcome. | Baseline, week 4, week 8 | 
| Change in the level of independence to perform daily living activities | Measured with the Barthel Index, score range 0-100, a higher score indicates a higher level of independence. | Baseline, week 4, week 8 |