Progress Adult Study

Study Overview
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Brief Summary
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The purpose of this study is to study the HIV disease progression in HIV-infected Thai Adult.

Detailed Description
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This is a multicenter, observational prospective cohort study. All HIV-infected patients from Bamrasnaradura Institute, Sanpatong Hospital and HIV-NAT, Thai Red Cross AIDS Research Centre, are followed to assess HIV disease progression.

Official Title
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The Thai HIV Disease Progression: An Observational Database

Conditions
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HIV, Depression

Intervention / Treatment
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* Drug: standard regimens according to the Thai Ministry of Public Health national guidelines


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: There is evidence that HIV infection true (blood positive results by ELISA (ELISA) has been confirmed or detected evidence co-infection. HIV in the body by PCR, HIV-RNA PCR).Currently on PI regimens Signed consent form Age> 18 years Exclusion Criteria: Patients who came for treatment in a department other than out patient, such as inpatient or emergency room. Patients are not willing to receive treatment on a regular basis in all 3 hospitals as patients normally receive treatment at other hospitals on a regular basis. However, due to urgent events. Need to receive treatment in hospital and three of. Patients who have been diagnosed by doctors as a Psychological disorder that can not store the data. Patients who have been diagnosed by a medical condition that Alcoholism

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>long-term follow-up of HIV-infected patients on ART | Drug: standard regimens according to the Thai Ministry of Public Health national guidelines<br>* Participants may receive any of the standard regimens. These regimens are recommended in the Thai Ministry of Public Health National guidelines for the treatment of HIV in children. Change of treatment will be according to the treating physicians.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HIV related adverse events | Time until patient has HIV related adverse events | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Immunological failure | time to immunological failure | 1 year | 
| virological failure | time to virological failure | 1 year | 
| the change of quality of life | time to change of quality of life | 1 year | 
| depression | time when patient develops depression | 1 year | 
| genotypic resistance | time to developing genotypic resistance | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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HIV related adverse events, immunological failure, virological failure, quality of life, depression, genotypic resistance