Imbalances of Regional Pulmonary Ventilation in Patients With Post-acute-COVID-19

Study Overview
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Brief Summary
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Investigation of the correlation of CT-morphological changes of the lung compared to regional ventilation distribution on electrical impedance tomography in patients with post-acute-Covid-19 symptoms.

Detailed Description
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Prospective non-interventional, monocentric observational study on imbalances in regional lung ventilation compared to chest CT in post-acute-Covid-19. The aim is to verify the agreement between computerized tomography derived imaging variables and electrical impedance tomography in detecting lung ventilation imbalances. The primary study objective is to match CT morphological changes in regional ventilation in post-acute-COVID-19 patients and/or changes in lung function examination, with changes that can be visualized by electroimpedance tomography.

Official Title
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Imbalances of Regional Pulmonary Ventilation in Patients With Post-acute-COVID-19 Symptoms

Conditions
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COVID-19 Pneumonia, Post-acute COVID-19 Syndrome, Electric Impedance

Intervention / Treatment
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* Diagnostic Test: additional EIT Measurement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: all patients undergoing a Chest CT due to suspected post-acute-Covid-19-syndrome >18 years informed consent. Exclusion Criteria: trauma patients and patients with unstable spinal injuries or fractures patients with an BMI over 50 patients with uncontrolled body movements Patients with a pacemaker

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control cohort<br>lung-healthy volunteers get a EIT measurement | |
| Case cohort<br>Patients who receive standard CT and pulmonary function testing also receive electroimpedance tomography measurement | Diagnostic Test: additional EIT Measurement<br>* Patients who receive standard CT and pulmonary function testing also receive electroimpedance tomography measurement. The lunghealthy Patients in the control group only receive a EIT.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between tomography and electroimpedance tomography | The primary study objective is to match CT morphological changes in regional ventilation in post-COVID patients and/or changes in lung function examination with changes that can be visualized by electroimpedance tomography. | until May 2022 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between lung function testing and electroimpedance tomography |  | until May 2022 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Electric Impedance, Tomography, regional ventilation, post-acute-COVID-19 syndrome, post-COVID-19, EIT, electroimpedance tomography, long-COVID, CT