Sweat and Gas Sensor for Healthy Skin and Atopic Dermatitis

Study Overview
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Brief Summary
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Pilot study of a wearable gas and sweat skin sensor

Detailed Description
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The objective of this study is exploratory and deploys two wearable sweat and gas sensors which detect the composition of sweat proteins and volatile gases emitted from the skin in healthy subjects and patients with atopic dermatitis.

Official Title
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Exploratory Study of Sweat Cytokines and Insensible Gas Losses From Skin in Healthy Normal Adults and Patients With Atopic Dermatitis

Conditions
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Healthy Adults, Atopic Dermatitis, Wearables, Sweat Sensor, Gas Sensor

Intervention / Treatment
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* Device: Gas sensor
* Device: Sweat Sensor


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥18 years old Subjects willing and able to comply with requirements of the protocol Healthy adults or subjects with atopic dermatitis Exclusion Criteria: Age <18 years old Subjects unwilling and able to comply with requirements of the protocol History of skin allergy to medical adhesive tape History of heat stroke, heat related or exercise related Non-English speaking subjects

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy Adults<br>Healthy adults with no prior diagnosis of atopic dermatitis | Device: Gas sensor<br>* The gas sensor is an airtight gas capsule attached with a floating solid phase microextraction (SPME) tube. SPME uses a fiber coated with a nontoxic liquid (polymer), and a nontoxic solid (sorbent). The fiber coating extracts the compounds from the gas being released from the skin. Only the glass sample is in contact with the skin.<br>Device: Sweat Sensor<br>* The sweat sensor is a soft, flexible device that rests on the skin and collects secreted sweat through capillary action. The device is held in place by medical-grade acrylic adhesive film.<br>|
| Atopic Dermatitis<br>Adults with prior diagnosis of Atopic Dermatitis from board certified dermatologist | Device: Gas sensor<br>* The gas sensor is an airtight gas capsule attached with a floating solid phase microextraction (SPME) tube. SPME uses a fiber coated with a nontoxic liquid (polymer), and a nontoxic solid (sorbent). The fiber coating extracts the compounds from the gas being released from the skin. Only the glass sample is in contact with the skin.<br>Device: Sweat Sensor<br>* The sweat sensor is a soft, flexible device that rests on the skin and collects secreted sweat through capillary action. The device is held in place by medical-grade acrylic adhesive film.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of gas exudates | Evaluation of protein contents from gas exudates from the skin | 20 minutes | 
| Evaluation of sweat proteins | Evaluation of protein contents from sweat from the skin | 20 minutes |