CT-guided Localization for Micro Hepatocellular Carcinoma Before Surgical Resection

Study Overview
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Brief Summary
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In this project, the preoperative anatomical location of micro hepatocellular carcinoma under the guidance of CT can provide guidance for accurate surgical resection. It may also shorten the operation time and reduce intraoperative bleeding.

Detailed Description
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General and basic information of the patients included in the study was collected. After preoperative preparation was completed, on the day of surgery, disposable pulmonary nodular localization needle (Ningbo Sonjiecang Biological Technology Co., LTD., Model: SS510-10) was used for the localization of micro hepatocellular carcinoma that could be found by preoperative CT enhancement or MRI. After the micro hepatocellular carcinoma was located under the guidance of CT, and then the patient was sent to the operating room. During the operation, the lesion was removed according to the tail line of the positioning needle and the position of the positioning needle.

Official Title
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The Feasibility of CT-guided Localization for Micro Hepatocellular Carcinoma Before Surgical Resection

Conditions
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Cirrhosis, Liver, Hepatocellular Carcinoma

Intervention / Treatment
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* Procedure: CT-guided localization for micro hepatocellular carcinoma before surgical resection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Be at least 18 years old and give informed consent to participate in the study A preoperative (clinical, radiological, or histological) diagnosis of cirrhosis of the liver due to any cause. micro hepatocellular carcinoma (diameter less than 1cm). Preoperative CT plain scan could not find the lesion, and preoperative B-ultrasound could not find the lesion. Preoperative CT enhancement or MRI can detect the lesion. Exclusion Criteria: Child-Pugh grade C Uncontrolled Hypertension Severe lung dysfunction Severe cardiac dysfunction

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: CT-guided localization for micro hepatocellular carcinoma before surgical resection<br>fter preoperative preparation was completed, on the day of surgery, disposable pulmonary nodular localization needle (Ningbo Sonjiecang Biological Technology Co., LTD., Model: SS510-10) was used for the localization of micro hepatocellular carcinoma that could be found by preoperative CT enhancement or MRI. After the micro hepatocellular carcinoma was located under the guidance of CT, and then the patient was sent to the operating room. During the operation, the lesion was removed according to the tail line of the positioning needle and the position of the positioning needle. | Procedure: CT-guided localization for micro hepatocellular carcinoma before surgical resection<br>* After preoperative preparation was completed, on the day of surgery, disposable pulmonary nodular localization needle (Ningbo Sonjiecang Biological Technology Co., LTD., Model: SS510-10) was used for the localization of micro hepatocellular carcinoma that could be found by preoperative CT enhancement or MRI. After the micro hepatocellular carcinoma was located under the guidance of CT, and then the patient was sent to the operating room. During the operation, the lesion was removed according to the tail line of the positioning needle and the position of the positioning needle.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The position of the needle | The distance (mm) of the needle to the edge of hepatocellular carcinoma | During operation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Operation time | The length of operation time (min) | During operation | 
| Intraoperative bleeding | The volume of intraoperative bleeding (ml) | During operation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cirrhosis, hepatocellular carcinoma, localization needle