The Motoric Cognitive Risk Syndrome in the Canadian Population

Study Overview
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Brief Summary
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Cognition and locomotion are two human abilities controlled by the brain. Their decline is highly prevalent with aging, and is greater than the simple sum of their respective prevalence, suggesting a complex age-related interplay between cognition and locomotion. Recently, a systematic review and meta-analysis has provided evidence that poor gait performance predicts dementia and, in particular, has demonstrated that motoric cognitive risk (MCR) syndrome, which has been described in cognitively healthy individuals and combines subjective cognitive complaint with objective slow gait speed, is a pre-dementia syndrome. The uniqueness of motoric cognitive risk (MCR)syndrome is that it does not rely on a complex evaluation or laboratory investigations. Thus, it is easy to apply in population-based settings. The overall objective of the proposal is to examine the epidemiology of the newly reported motoric cognitive risk (MCR) syndrome, in the Quebec population using the database of the NuAge study.

Official Title
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The Motoric Cognitive Risk Syndrome in the Canadian Population: Analysis of Baseline Assessment of the Canadian Longitudinal Study on Aging (CLSA)

Conditions
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Cognition Disorders in Old Age, Cardiovascular Diseases, Dementia

Intervention / Treatment
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* Other: Summarize of participants' characteristics using means and standard deviations or frequencies and percentages


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Individuals eligible for this study will be participants of the NuAge study Exclusion Criteria: Individuals not eligible for the NuAge study dementia mobility disability no information about cognitive complaint no measure of walking speed

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| CVRF<br>individuals with cardio-vascular risk factors and diseases | Other: Summarize of participants' characteristics using means and standard deviations or frequencies and percentages<br>* Participants' baseline characteristics will be summarized using means and standard deviations or frequencies and percentages, as appropriate.<br>|
| WCVRF<br>individuals without cardio-vascular risk factors and diseases | Other: Summarize of participants' characteristics using means and standard deviations or frequencies and percentages<br>* Participants' baseline characteristics will be summarized using means and standard deviations or frequencies and percentages, as appropriate.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardio-vascular risk factors and diseases assessed using reported health condition | medical history | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardio-vascular risk factors and diseases assessed using physical examination: BMI | body mass index | 1 day | 
| Cardio-vascular risk factors and diseases assessed using physical examination: HW ratio | hip-waist ratio | 1 day | 
| Cardio-vascular risk factors and diseases assessed using physical examination: blood pressure | (value of systolic, diastolic when participants are seated in an upright position in a chair) | 1 day | 
| Disability and functional limitations | Disability and functional limitations : ADL (activities of daily life) | 1 day | 
| Disability and functional limitations | Disability and functional limitations : IADL (instrumental activities of daily life) | 1 day | 
| Disability and functional limitations | History of falls during the past 12 months | 12 months | 
| Depression | measured by the 10 items of the Center for Epidemiological Studies Short Depression Scale. Participants with a score of 10 or greater are considered as depressed. Scores with more than 2 missing items will be excluded. | 1 day | 
| Cognitive performance | Prospective Memory Test (PMT) | 1 day | 
| Cognitive performance | Stroop Neurological Screening Test | 1 day | 
| Cognitive performance | Controlled Oral Word Association Test (FAS) | 1 day | 
| Cognitive performance | Choice Reaction Time Test (CRT) | 1 day | 
| physical and mental health | Number of drugs daily taken | 1 day | 
| physical and mental health | Self-perception of health and mental health | 1 day | 
| Physical performance | Muscle strength estimated using the handgrip strength | 1 day | 
| Physical performance | five-time sit-to-stand test | 1 day | 
| Physical performance | Physical Activity Scale for the Elderly, scored between 0 and 400, low scores indicate sarcopenia | 1 day |