Intense Pulsed Light in Meibomian Gland Dysfunctions

Study Overview
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Brief Summary
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Dry eye disease (DED) is an extremely common disease whose meibomian gland dysfunction is the main etiology. Polychromatic intense pulsed light (IPL) is a promising new therapeutic alternative but few clinical data have been published. A new IPL device has recently been marketed: LACRYSTIM (QUANTEL, France). The investigators have been using it in our clinical practice since June 2019. The investigators present a retrospective study on our first clinical results.

Official Title
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Intense Pulsed Light in Meibomian Gland Dysfunctions: Retrospective Study

Conditions
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Dry Eye Syndromes, Meibomian Gland Dysfunction

Intervention / Treatment
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* Device: intense pulsed light (usual practice)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with Dry eye disease with meibomian gland dysfunction, preferentially mild to moderate, and having benefited from intense pulsed light treatment. patient affiliated with a social security organization Exclusion Criteria: patient with incomplete follow-up

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with dry eye disease with meibomian gland dysfunction<br>Collected data from patient records for consultations Day 0, Day 15 and Day 45 (3 treatment sessions) and Months 3, Months 6 (follow-up consultations). - parameters used for each treatment session: duration of treatment session and intensity of intense pulsed light | Device: intense pulsed light (usual practice)<br>* collection data : parameters used for each treatment session: duration of treatment session and intensity of intense pulsed light<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lacrydiag in current clinical practice | The LacryDiag ocular surface analyzer is used for the diagnosis of dry eyes. | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| collection of adverse events | -data concerning the safety: presence or absence of adverse events during treatment or afterwards (burns, tingling, redness of skin ...) | 6 months | 
| Ocular Surface Disease Index questionnaire | measured in current clinical practice. This 12-item questionnaire assesses dry eye symptoms and the effects it has on vision-related function in the past week of the patient's life. The questionnaire has 3 subscales: ocular symptoms, vision-related function, and environmental triggers. | 6 months | 
| Slit lamp Photography x16 and x25 | in current clinical practice | 6 months | 
| Oxford Score | measured in current clinical practice. The Oxford score is used to assess epithelial damage to the cornea and conjunctiva. | 6 months | 
| Break-up time Test | measured in current clinical practice. The measurement of the tear film rupture time determines the stability of the tear film, i.e. the degree of humidification of the eyes. | 6 months | 
| Schirmer Test | measured in current clinical practice. Determination of the quantity of tears produced. | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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intense pulsed light