Impact of Air Pollution on the Autonomic Nervous System Activity and the Presence of Sleep Apnea in Older Subjects

Study Overview
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Brief Summary
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Impact of air pollution on the autonomic nervous system activity and presence of sleep apnea in older subjects.

Detailed Description
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The relation between the air pollution and morbidity, cardiovascular mortality was increasing interest. Analyses show an increase of respiratory difficulty, but also cardiac deaths in the daytime when the atmospheric pollution was increased. It was demonstrated that health effects of ambient air pollution in subjects presenting cardiac or lung difficulty were important. Mechanisms show a possible relation to autonomic nervous system (ANS) deactivation and mortality. Particularly, the ageing and ANS reach would be more predictive of cardiovascular events. Thus, we suggest estimating in 60 healthy volunteers from 60 to 80 years old, the impact of the air pollution on the autonomic nervous system activity and sleep apnea consequences.

Official Title
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Impact of Air Pollution on the Autonomic Nervous System Activity and the Presence of Sleep Apnea in Older Subjects: Longitudinal Multicentric Study

Conditions
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Healthy

Intervention / Treatment
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* Other: Air pollution study on healthy volunteers.


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: reside in Lyon and Saint-Etienne cities security social affiliated or beneficiary information note signed Exclusion Criteria: heart rate disorders pacemaker tabacco addiction or second-hand smoke morbid obesity (BMI > 30) insulin-dependent diabetes chronic disease on treatment antiarrythmic treatments

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Air pollution<br>The subjects will have to live in districts where important atmospheric pollution is established | Other: Air pollution study on healthy volunteers.<br>* The subjects are examined three times: First the volunteers get used to equipments. Second and third the volunteers sleep in a pollution or purified air.<br>* Other names: physiopathologic study;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Frequency analysis of heart rate variability |  | inclusion, 1 test night and 2 experimental nights | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analysis of sleep, diurnal somnolence, sleep latency and PRS impact on the life quality. |  | 1 test night and 2 experimental nights | 
| Hour index quantification of night respiratory events. |  | 1 test night and 2 experimental nights | 
| Hour index quantification of autonomic awakening during the sleep. |  | 1 test night and 2 experimental nights | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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air pollution, autonomic nervous system, sleep apnea, Heart rate variability, Healthy volunteers