Development & Validation of Preoperative Objective Physiological Evaluation

Study Overview
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Brief Summary
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This study will compare the measured oxygen consumption (VO2) obtained during sub-maximal exercise testing with the estimated VO2 derived from a non-exercise questionnaire.

Detailed Description
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All surgical patients presenting at the Preoperative Anesthesia & Surgical Screening (PASS Clinic) will complete the Duke Activity Status Index (DASI) self-reported questionnaire as standard of care. If the DASI score is 34 or greater, the patients will not be considered for the study. If the DASI score is 33 or lower, the patient will be considered as a potential study participant. Eligible study participants will then complete a sub-maximal exercise test (Six Minute Step Test, 6MST) with measured VO2. The VO2 is an integral part of preoperative assessment of cardiorespiratory fitness (CRF). A low CRF is associated with a higher incidence of post-operative complications and mortality. The study will evaluate the ability to estimate VO2 from exercise-derived measurement with questionnaire-derived estimation.

Official Title
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Development & Validation of Preoperative Objective Physiological Evaluation

Conditions
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Cardiorespiratory Fitness

Intervention / Treatment
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* Behavioral: Exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18 and older Able to speak English Ambulatory [assistive devices ok] Preoperative Anesthesia and Surgical Screening (PASS) clinic patient with DASI score <34 Able to provide informed consent Exclusion Criteria: Acute myocardial infarction (3-5 days) Unstable angina Severe untreated arterial hypertension at rest (>200 mm Hg systolic, >120 mm Hg diastolic) Resting heart rate > 120 bpm Room air desaturation at rest on room air <85% Inmate of correctional facility (i.e. prisoner) Diagnosed history of dementia Inability to ambulate independently Considered inappropriate to participate by Principal Investigator

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: All subjects will be asked to complete the exercise test and the fitness questionnaire
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 6MST VO2<br>Completion of 6MST exercise protocol | Behavioral: Exercise<br>* Calculate oxygen consumption<br>|
| Active Comparator: DASI VO2<br>Completion of DASI fitness activity questionnaire | Behavioral: Exercise<br>* Calculate oxygen consumption<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total amount of oxygen consumed per minute | Oxygen consumption measured in mL/min | Up to 15 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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areobic power, cardiopulmonary exercise testing, exercise capacity, functional capacity, physical activity