Incidence and Reasons for Preoperative Anemia in Elective Lower Joint Arthroplasty

Study Overview
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Brief Summary
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Preoperative anemia is an independent risk factor for the need for allogeneic transfusion during surgery and increased postoperative morbidity. Treatment of preoperative anemia is recommended. However the type of preoperative anemias in elective hip- and knee surgery has only been sparsely studied. This observational study aims to investigate the incidence and type of anemias prior to elective hip- and knee arthroplasty.

Detailed Description
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Preoperative anemia is an independent risk factor for the need for allogeneic transfusion during surgery and increased postoperative morbidity. In elective orthopedic surgery, international guidelines recommends treatment of preoperative anemia including the use of Iron supplements for anemias associated with iron deficiency. In addition, low iron stores in both anemic and non-anemic patients may delay postoperative hemoglobin recovery. However, the reasons for preoperative anemia and the prevalence of patients with low iron stores have only been sparsely studied in elective hip- and knee arthroplasty. This observational study aims to investigate the incidence and type of anemias prior to elective hip- and knee arthroplasty.

Official Title
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Incidence and Reasons for Preoperative Anemia in Elective Lower Joint Arthroplasty - A Descriptive Study

Conditions
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Anemia, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age > 18 years Scheduled for elective primary hip- or knee replacement. Exclusion Criteria: Not possible to obtain preoperative blood sample.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Elective Total Hip- or Knee arthroplasty patients<br>Patients scheduled for elective Hip- or knee replacement at Hvidovre Hospital, Denmark. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anemia Classification - Biochemical classification from preoperative venous blood samples | Biochemical classification from preoperative venous blood samples | Date of preoperative blood sampling | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of Anemia according to WHO definitions | According to WHO definitions | Date of preoperative blood sampling | 
| Proportions of non-anemic patients with low irons stores | Low Ferritin or Transferin saturation (TSAT) | Date of preoperative blood sampling | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Patient Blood Management, Preoperative anemia, Hip replacement, Knee replacement