Long-Term Effects of Treatment in Patients Previously Treated for Childhood Hodgkin's Lymphoma

Study Overview
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Brief Summary
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RATIONALE: Assessing the long-term effects of cancer treatment in cancer survivors may help improve the ability to plan effective treatment and follow-up care. PURPOSE: This clinical trial is studying the long-term effects of treatment in patients who were previously treated for childhood Hodgkin's lymphoma.

Detailed Description
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OBJECTIVES: Determine the cumulative incidence and characterize the spectrum of selected adverse physiologic and psychosocial outcomes, using self-report and clinical evaluation, in patients previously treated for childhood Hodgkin's lymphoma. Compare the cumulative incidence and spectrum of self-reported adverse outcomes of these patients, using data collected at a comparable time period after diagnosis, with Hodgkin's lymphoma survivors from the Childhood Cancer Survivor Study (CCSS). Compare self-reported health-related outcomes with outcomes detected by clinical evaluation and medical record review of each group of patients. OUTLINE: This is a cohort, cross-sectional, multicenter study. Contemporary group: Patients complete a self-report of long-term outcomes questionnaire and a comprehensive psychosocial questionnaire. A medical record review is then performed. Patients then undergo a comprehensive risk-based clinical evaluation with specific examinations and studies based upon the Children's Oncology Group Late Effects Screening Guidelines and the patients' specific therapeutic exposures. Childhood Cancer Survivor Study (CCSS) group: Patients undergo a telephone interview and have medical records reviewed to validate select self-reported long-term outcomes. Patient replies from the baseline CCSS questionnaire (which was completed at certain timepoints after diagnosis) are reviewed for targeted long-term outcomes. PROJECTED ACCRUAL: Approximately 1,000 patients will be accrued for this study.

Official Title
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Health-Related Outcomes For Hodgkin's Disease Survivors

Conditions
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Long-term Effects Secondary to Cancer Therapy in Children, Lymphoma

Intervention / Treatment
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* Other: medical chart review
* Other: questionnaire administration
* Procedure: management of therapy complications


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Contemporary cohort At least 5 years since diagnosis of Hodgkin's lymphoma Diagnosed between the years 1987-2001 21 and under at diagnosis No evidence of disease Prior treatment on 1 of the following protocols during the years 1987-2001: Children's Cancer Group (CCG) CCG-5942, CCG-59704 Pediatric Oncology Group (POG) POG-8625, POG-8725, POG-9425, POG-9426 Pediatric Hodgkin's Consortium: VAMP, VEPA, VAMP/COP Institutional protocols COPP/ABV, MOPP/ABVD, ABVD Childhood Cancer Survivor Study (CCSS) Hodgkin's lymphoma cohort Current enrollment in the CCSS Diagnosed between the years 1976-1986 Completed baseline questionnaire at comparable timepoints (as the contemporary cohort) after diagnosis PATIENT CHARACTERISTICS: Age Any age Performance status Not specified Life expectancy Not specified Hematopoietic Not specified Hepatic Not specified Renal Not specified PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy Not specified Endocrine therapy Not specified Radiotherapy Not specified Surgery Not specified
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| All patients<br>Self report/Medical record review/ clinical eval | Other: medical chart review<br> <br> Other: questionnaire administration<br> <br> Procedure: management of therapy complications<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Risk for a specific adverse condition until the earliest of death, development of the adverse condition, loss to follow up, or completion of questionnaire | The calculation of the incidence rates will be done in two ways: (a) using the self-report incidence of adverse conditions; and (b) using the incidence of adverse conditions validated by clinical evaluation. | length of study | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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long-term effects secondary to cancer therapy in children, stage I childhood Hodgkin lymphoma, stage II childhood Hodgkin lymphoma, stage III childhood Hodgkin lymphoma, stage IV childhood Hodgkin lymphoma