Personality Disorders and Substance Use Disorders in a Sexual Context in the Man Having Sex With Other Men Population

Study Overview
=================
Brief Summary
-----------------
Chemsex refers to the use of psychoactive drugs in a sexual context, mainly cathinones, GHB/GBL, methamphetamine, cocaine and ketamine. This can cause infectious or psychiatric complications, addictions, and often goes with high risk sexual behaviours. Recent studies have highlighted the relationship between personality disorders, substance use disorders and risky sexual behaviours. It is important to understand the factors associated with chemsex in order to offer adapted prevention and care plans. The study hypothesis is that personality disorders, evaluated with the PDQ-4+ questionnaire, are more frequent among man having sex with other men with a substance use disorder linked to chemsex than among man having sex with other men who have never practised chemsex.

Official Title
-----------------
A Study of the Relationship Between Personality Disorders and Substance Use Disorders in a Sexual Context in the Man Having Sex With Other Men Population - An Observational Study Based on a Cross-sectional Survey.

Conditions
-----------------
Substance Use Disorders

Intervention / Treatment
-----------------
* Other: Questionnaires and semi-structured interview


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age over 18 Men who have Sex with Men No opposition to participate to the study Chemsex group: to attend an addiction care center for past or present mild, moderate or severe substance-related disorder(s) according to DSM-V criteria, occurring in a sexual context and concerning cathinones, GHB/GBL, methamphetamine, cocaine and/or ketamine. Control group: to consult for a PrEP prescription and never have used cathinones, GHB/GBL, methamphetamine, cocaine or ketamine before or during sex. Exclusion Criteria: Deprivation of liberty Guardianship Chemsex group: simple experience of chemsex without substance use disorder

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Chemsex<br>Men who have Sex with Men (MSM) attending an addiction care center for past or present mild, moderate or severe substance-related disorder(s) according to DSM-V criteria, occurring in a sexual context and concerning cathinones, GHB/GBL, methamphetamine, cocaine and/or ketamine. | Other: Questionnaires and semi-structured interview<br>* Questionnaires : PDQ-4+ (personality disorders), HAD (Anxiety and Depression), AUDIT-c (Alcohol consumption), CTQ-SF (Childhood Trauma Questionnaire). Semi-structured interview : Evaluation of socio-demographic characteristics, psychiatric and addiction comorbidities, sexually transmitted infections, sexual practices, sexual dysfunction, hypersexual disorder.<br>|
| Control<br>Men who have Sex with Men (MSM) consulting for a PrEP (HIV Pre-Exposure Prophylaxis) prescription who have never used cathinones, GHB/GBL, methamphetamine, cocaine or ketamine before or during sex. | Other: Questionnaires and semi-structured interview<br>* Questionnaires : PDQ-4+ (personality disorders), HAD (Anxiety and Depression), AUDIT-c (Alcohol consumption), CTQ-SF (Childhood Trauma Questionnaire). Semi-structured interview : Evaluation of socio-demographic characteristics, psychiatric and addiction comorbidities, sexually transmitted infections, sexual practices, sexual dysfunction, hypersexual disorder.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Personality disorders | Positive score for 1 or more DSM-V personality disorders(PD) using French version of the PDQ4+,Personality Diagnostic Questionnaire-Version4,comprising: Combined score of overall personality disturbance (ranges0 to 93);higher values reflect a more important personality disturbance Borderline PD:Score Ranges(SR) 0 to 9,positive(+) if ≥ 5 Narcissistic PD:SR 0 to 9,+ if ≥5 Histrionic PD:SR 0 to 8,+ if ≥5 Antisocial PD:SR 0 to 8,+ if ≥4 and criteria 99 positive Avoidant PD:SR 0 to 7,+ if ≥4 Dependent PD:SR 0 to 8,+ if ≥5 Obsessive-Compulsive PD:SR 0 to 8,+ if ≥4 Paranoid PD:SR 0 to 7,+ if ≥4 Schizoid PD:SR 0 to 7,+ if ≥4 Schizotypal PD:SR 0 to 9,+ if ≥5 Questionnaire must be interpreted with caution if 1 of the 2 Suspect Questionnaire items is +, or if at least 2 of the 4 Too Good items are + Negativistic and depressive PD are evaluated with the PDQ4+ but are not part of the outcome measures in the study | 1 day |