Efficacy and Safety of H.P. Acthar Gel for the Treatment of Refractory Cutaneous Manifestations of Dermatomyositis

Study Overview
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Brief Summary
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This study will assess the safety and efficacy of H.P. Acthar gel for treating the cutaneous manifestations in patients with refractory classic dermatomyositis, juvenile dermatomyositis, and amyopathic dermatomyositis. Our hypothesis is that H.P. Acthar gel will be both safe and effective for such patients.

Detailed Description
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Adult and juvenile dermatomyositis (DM) are systemic immune-mediated inflammatory diseases most commonly affecting the skin and musculoskeletal system. Amyopathic dermatomyositis is a subtype of dermatomyositis that affects only the skin and lacks the characteristic muscle involvement. Treatment of these conditions, in particular the cutaneous manifestations, is challenging and currently no universally effective single treatment exists. Many patients have cutaneous manifestations that are refractory to numerous medications. H.P. Acthar gel (adrenocorticotropic hormone gel) received FDA approval for treatment of a variety of diseases, including dermatomyositis, in 1952. Despite this there is a paucity of clinical data concerning the efficacy of H.P. Acthar gel for treating dermatomyositis. Recently a small, retrospective case series describing significant improvement in both cutaneous and musculoskeletal symptoms in 5 patients with refractory dermatomyositis treated with H.P. Acthar gel was reported and has resulted in renewed interest in use of this medication in dermatomyositis patient (reference below). The proposed efficacy of H.P. Acthar gel has been attributed to its unique ability to induce production of endogenous cortisol, corticosterone, aldosterone, and to bind melanocortin receptors on lymphocytes and other cells to modulate immunologic responses.

Official Title
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Efficacy and Safety of H.P. Acthar Gel for the Treatment of Refractory Cutaneous Manifestations of Dermatomyositis

Conditions
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Dermatomyositis, Juvenile Dermatomyositis

Intervention / Treatment
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* Drug: H.P. Acthar Gel


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Must be 18 years of age or older with refractory cutaneous symptoms related to either classic dermatomyositis (CD), juvenile dermatomyositis (JD), or amyopathic dermatomyositis(AD). Diagnosis will be based on either Bohan and Peter criteria (CD and JD) or Sontheimer's criteria (AD) Must have had a skin biopsy with histologic features consistent with dermatomyositis and current cutaneous manifestations consistent with dermatomyositis. Although not mandatory, patients with evidence of current or previous active myositis will be eligible for enrollment. Patients will be considered to have refractory disease if cutaneous manifestations exist despite treatment with steroids and at least one steroid-sparing systemic treatment commonly found to be useful in patients with dermatomyositis. These may include azathioprine, cyclosporine, mycophenolate mofetil, IVIG, methotrexate, cyclophosphamide, chlorambucil, sirolimus, adalimumab, infliximab and rituximab. Use of topical medications and sunscreen currently and in past will be noted but not weighed for assessment of refractory cutaneous disease. Exclusion Criteria: Patients with dermatomyositis who have minimal-to-no active cutaneous features (focal involvement with less than 1% total body surface area involved or minimal modified CDASI activity score). Patients whose cutaneous findings are not consistent with dermatomyositis and/or have previous biopsy results suggestive of an alternative diagnosis Patients with inflammatory myositis other than dermatomyositis, such as polymyositis or inclusion body myositis. Patients with malignancy-associated dermatomyositis Patients with clear features of an overlap myositis Patients younger than 18 years old Patients with acutely active or chronic infections. Patients with uncontrolled diabetes, hypertension, cardiovascular, hepatic, or renal disease Pregnant or lactating females. Patients with any medical condition that is felt by the primary investigator to place the patient at unreasonable risk for adverse effects during treatment with H.P. Acthar. Hypersensitivity to H.P. Acthar, any of its components (allergy to pig-derived proteins) Patients with osteoporosis Patients who have had surgery within 8 weeks of screening Patients with a history of or current gastric ulcers Patients taking daily doses of systemic corticosteroids greater than the equivalent of 40mg prednisone.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: H.P Acthar Gel<br>80 U (1 mL) of H.P. Acthar gel via subcutaneous injection twice weekly for 24 weeks | Drug: H.P. Acthar Gel<br>* 80 U (1 mL) of H.P. Acthar gel via subcutaneous injection twice weekly for 24 weeks<br>* Other names: Acthar Gel;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in cutaneous manifestations of dermatomyositis at 1, 3, and 6 months | Statistically significant change between baseline and 1, 3, and 6 months in cutaneous manifestations of dermatomyositis based on modified CDASI (modified Cutaneous Dermatomyositis Disease Area and Severity Index) scores at these timepoints. | 6 months | 
| Change from baseline in cutaneous manifestations of dermatomyositis at 1, 3, and 6 months | Change between baseline and 1, 3, and 6 months in cutaneous manifestations of dermatomyositis based on Physician's Global Assessment scores at these timepoints. | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in patient assessment of dermatomyositis at 1, 3, and 6 months | Statistically significant change between baseline and 1, 3, and 6 months in patient assessed Global Patient Score at these timepoints. | 6 months | 
| Change from baseline in patient assessment of dermatomyositis at 1, 3, and 6 months | Statistically significant change between baseline and 1, 3, and 6 months in patient assessed Global Itch Score at these timepoints. | 6 months | 
| Change from baseline in patient assessment of dermatomyositis at 1, 3, and 6 months | Statistically significant change between baseline and 1, 3, and 6 months in patient assessed Dermatology Life Quality Index (DLQI) scores at these timepoints. | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dermatomyositis, Acthar gel