Evaluation of Use of Brain Activity Monitoring for Prediction of Migraine Attacks

Study Overview
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Brief Summary
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This study evaluates the use of brain activity monitoring for prediction of migraine attacks in an expected time scale of 12-48 hours prior to the migraine attack.

Detailed Description
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The study will be conducted in one are. Participants diagnosed with migraine, will be evaluated for their EEG characteristics as well as daily migraine related clinical and general status. Participants' monitoring will be conducted for 20 times for a duration of one month.

Official Title
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A Feasibility Study for Examination the Use of Brain Prefrontal Activity Monitoring, for Early Detection of Migraine Attack

Conditions
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Migraine

Intervention / Treatment
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* Device: EEG monitoring (MindWave by NeuroSky)
* Device: EEG monitoring (EPOC by Emotiv)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosed with migraine by a neurologist. Male or Female, aged 18 -50 years. Able and willing to comply with all study requirements. Having 3-10 migraine attacks per month. Exclusion Criteria: Diagnosed with chronic pain, neurological or psychiatric disorders. Current or past use of anti-depressants. A user of recreational or illicit drugs or has had a recent history of drug or alcohol abuse or dependence. History of seizures Head injury with consciousness loss in the last three months. Diagnosed as ADHD and/or use of Ritalin. Hearing disorder and/or known ear drum impairment. Having migraine attacks occurring only during the menstruation.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Participants diagnosed with migraine<br>EEG monitoring (MindWave by NeuroSky and EPOC by Emotiv) | Device: EEG monitoring (MindWave by NeuroSky)<br>* EEG evaluation will be conducted for duration of 10 minutes. 5 minutes without auditory stimulation and 5 minutes with auditory stimulation performed using standard headphone or earphones to reduce external noises.<br>Device: EEG monitoring (EPOC by Emotiv)<br>* EEG evaluation will be conducted for duration of 10 minutes. 5 minutes without auditory stimulation and 5 minutes with auditory stimulation performed using standard headphone or earphones to reduce external noises.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurements of brain electrical signal in Micro volt. | Measurements of brain electrical signal in Micro volt will be quantified by an algorithm and correlated to reported migraine cycle (as reported by migraine patients in questionnaires). | 1 months |