Double-Blind, Randomized, Placebo-Controlled Study of Low Dose Oral Interferon Alfa-n3 (Human Leukocyte Derived) in ARC Patients

Study Overview
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Brief Summary
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To conduct a parallel-group, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy of an orally administered low dose interferon alfa-n3 as an immunomodulator in the treatment of mild to moderate symptomatic HIV+, AIDS-related complex (ARC) patients.

Detailed Description
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The study has been extended to offer 52 weeks of maintenance therapy after the 10 weeks of the placebo controlled period are concluded successfully.

Official Title
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Double-Blind, Randomized, Placebo-Controlled Study of Low Dose Oral Interferon Alfa-n3 (Human Leukocyte Derived) in ARC Patients

Conditions
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HIV Infections

Intervention / Treatment
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* Drug: Interferon alfa-n3


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria Concurrent Medication: Allowed: Zidovudine (AZT). Patients must have: Diagnosis of AIDS related complex (ARC). Given written informed consent. Been receiving a dose of = or < 600 mg/day of zidovudine (AZT) at least 90 days prior to study entry IF they are currently taking AZT. Prior Medication: Allowed: Zidovudine (AZT) at a dose = or < 600 mg/day at least 90 days prior to study entry. Exclusion Criteria Co-existing Condition: Patients with the following conditions or symptoms are excluded: History of AIDS-defining condition or evidence of AIDS dementia. Evidence of chronic hepatitis with severe liver dysfunction, or other active gastrointestinal, renal, respiratory, endocrine, hematologic, cardiovascular or psychiatric disorder that would limit the subject's ability to complete the 12 weeks of the study period. Concurrent Medication: Excluded: Ketoconazole. Trimethoprim / sulfamethoxazole (TMP/SMX). Experimental medications. Patients with the following are excluded: Absolute CD4 count of < 100 or > 350 cells/mm3. Any disease or disorder listed in Patient Exclusion Co-existing Conditions. Unlikely or unable to comply with the requirements of the protocol. Unwilling or unable to give informed consent. Development of antibodies to interferon during prior interferon therapy that occurred > 3 months prior to study entry. Prior Medication: Excluded within 45 days of study entry: Immunomodulators (e.g., BCG vaccine, isoprinosine). Chemotherapy. Steroids. Excluded within 3 months of study entry: Interferon therapy. Active IV drug abuse.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Interferon alfa-n3|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Acquired Immunodeficiency Syndrome, AIDS-Related Complex, Interferon Type I, Recombinant