Effect of Pregabalin or Adductor Canal Block on Postoperative Analgesia

Study Overview
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Brief Summary
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arthroscopically Anterior Cruciate Ligament Reconstruction (ACL) under spinal anesthesia were included in this study.

Detailed Description
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Patients who American Society of Anesthesiologists (ASA) classification I to II scheduled to undergo arthroscopically assisted ACL reconstructions under spinal anesthesia are included in this study. The first group is administered 150 mg oral pregabalin 1 hour before surgery and the postoperative sham block was performed with an ultrasound probe. The second group is the control group; patients in this group are administered a placebo capsule 1 hour before surgery and sham block was performed with an ultrasound probe.The third group is administered a placebo capsule 1 hour before surgery and postoperative adductor canal block is performed. All patients will be received postoperative a tramadol i.v. patient control analgesia device. At the end of 24 hours, the total amount of tramadol consumed by the patient will be recorded from the patient control analgesia. NRS score, white fast track, satisfaction will be questioned.

Official Title
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Effect of Pregabalin or Adductor Canal Block on Postoperative Analgesia After Arthroscopic Anterior Cruciate Ligament Reconstruction (ACL)

Conditions
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Postoperative Pain After Knee Arthroscopy

Intervention / Treatment
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* Drug: pregabalin (lyrica)
* Drug: Placebo oral tablet
* Drug: adductor canal block including bupivacaine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients between the ages of 18 and 70 years American Society of Anesthesiologists I or II Scheduled to undergo knee arthroscopy Exclusion Criteria: allergic to any medicines History of drug or alcohol abuse, Opioids or sedative medications History of psychiatric conditions Pregnant or lactating women

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: pregabalin (lyrica)<br>pregabalin (lyrica) 150 mg preoperative 1 hour before and the postoperative sham block will perform. | Drug: pregabalin (lyrica)<br>* preoperative pregabalin and the postoperative sham block will perform.<br>|
| Placebo Comparator: placebo group<br>a placebo capsule 1 hour before surgery and the postoperative sham block will perform. | Drug: Placebo oral tablet<br>* The preoperative placebo oral tablet and the postoperative sham block will perform.<br>|
| Active Comparator: adductor channel block group<br>A preoperative placebo capsule will be given.This group will receive postoperative adductor channel block including 10 mL of 0.25% bupivacaine with 5 μg/mL epinephrine | Drug: adductor canal block including bupivacaine<br>* The preoperative placebo oral tablet and adductor channel block including 10 mL of 0.25% bupivacaine with 5 μg/mL epinephrine<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 11-point numerical rating scale (NRS) | 11-point numerical rating scale for pain (0='no pain' and 10='worst pain possible pain') were explained. | 24 hours | 
| tramadol consumption | 24 hours tramadol consumption will be recorded as milligrams | 24 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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pregabalin, adductor canal block, postoperative pain