Fluid and Nutrition in Elective Hip Surgery

Study Overview
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Brief Summary
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The purpose of this study is to determine whether fluid or glucose administration before hip replacement surgery minimizes postoperative muscle breakdown (catabolism), fatigue and disturbances in carbohydrate metabolism.

Detailed Description
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How can a simple and safe way to measure the body's tendency to transient diabetes associated with surgery? Can fluid or glucose administration before elective hip surgery, minimizing post-operative muscle breakdown (catabolism), fatigue and disturbances in carbohydrate metabolism?

Official Title
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Fluid and Nutrition in Elective Hip Surgery

Conditions
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Hip Surgery Corrective

Intervention / Treatment
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* Dietary Supplement: Water administration
* Dietary Supplement: carbohydrate drink
* Behavioral: Fasting.


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient scheduled for hip surgery. Exclusion Criteria: Endocrinological disorders.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Fasting<br>patients undergo surgery in the fasting state | Behavioral: Fasting.<br>* The patient is fasting from midnight before the surgery.<br>|
| Active Comparator: Water administration<br>Patients undergo hip surgery after receiving 800 ml water by mouth the morning 2 hours before surgery | Dietary Supplement: Water administration<br>* patients undergo hip surgery after receiving 800 ml water by mouth in the morning before the surgery.<br>* Other names: Tap water;|
| Active Comparator: carbohydrate drink<br>Patients undergo hip surgery after receiving 800 ml carbohydrate drink by mouth | Dietary Supplement: carbohydrate drink<br>* 800 ml carbohydrate drink by mouth the evening before surgery and 400 ml carbohydrate drink by mouth 2 hours before surgery<br>* Other names: PreOp Nutricia ( Nutricia Nordic AB);|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Insulin Sensitivity (Percent) | Insulin sensitivity (micro-mol per kg per minute glucose uptake) was calculated based on an intravenous glucose tolerance test (Theor Biol Med Model 2011, 8: 12) on the day before surgery. The percent change was taken as (day after - day before) / day before | Day before surgery (approximately 3 PM) and in the morning after surgery (approx. 7.30 AM). | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle Catabolism | Assessed by the ratio of 3-methylhistidine/creatinine in excreted urine (unit: mmol/mmol).This is an amino acid unique to muscle that does not undergo intermediary metabolism, meaning that its urinary excretion is an index of the degree of muscle catabolism. | From the morning after surgery (07.30) up to the morning two days after sthe surgery (07.30) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Hip surgery, Metabolism, Glucose, Body fluids, Complications