Global Cardiovascular Risk Consortium

Study Overview
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Brief Summary
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The Global Cardiovascular Risk Consortium (GCVRC) comprises harmonized data from nearly 1.7 Mio individuals of 126 cohorts across 43 countries and aims to elucidate the distribution of five major cardiovascular risk factors (body mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and their impact on cardiovascular disease (CVD) by geographical region and sex.

Detailed Description
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Previous literature reported a small number of modifiable risk factors that might explain up to 90% of certain CVD subtypes. If and to what extent regional differences in risk factor levels contribute to new-onset CVD remains to be elucidated. In the Global Cardiovascular Risk Consortium (GCVRC) we focus on five major cardiovascular risk factors: Body mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes. We aim to show the extent to which the distribution, population attributable risk, and predictive value of these factors differ geographically and by sex. Understanding of these issues is essential to guide regionally effective CVD prevention and therapy strategies, to determine residual risk, and to improve global cardiovascular health. The GCVRC uses individual-level harmonized data from nearly 1.7 million individuals in 126 cohorts across 43 countries, categorized in 8 geographical regions (based on amodification of WHO regions) - North America, Latin America, Sub-Saharan Africa, North Africa and Middle East, Western Europe, Eastern Europe and Russia, Asia, Oceania. Cox regression analyses and population attributable fractions (PAFs) for 10-year incident CVD are calculated for the five risk factors by geographical region and sex to determine the percentage of CVD burden that may be preventable by control of these risk factors. The results will influence regionally adapted prevention strategies to reduce the global CVD burden.

Official Title
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Impact of Modifiable Cardiovascular Risk Factors on Incident Cardiovascular Disease by Geographical Region and Sex

Conditions
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Cardiovascular Diseases, Heart Diseases, Coronary Disease, Myocardial Infarction, Angina, Unstable, Stroke, Myocardial Revascularization

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: population-based cohort: individuals with information on the traditional CVD risk factors including body mass index (BMI), systolic blood pressure (SBP), non-high-density lipoprotein cholesterol (non-HDL-C), current smoking, and diabetes, as well as the outcome fatal or non-fatal CVD. Exclusion Criteria: participants with age below 18 years no information on the outcome of interest (CVD incidence or mortality) no information on the exposure of interest (CVD risk factors) History of CVD at baseline

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiovascular disease (CVD) | Non-fatal myocardial infarction, ischemic heart disease death, unstable angina pectoris, cardiac revascularization, unclassifiable death, fatal and non-fatal stroke (any type). The type of outcome measurement varied across cohorts. CVD cases and subtypes were assessed by questionnaire information, national hospital discharge registry data, causes of death registry data or central death registries depending on the study protocol of the respective cohort studies. | 5-7 years of follow-up | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cardiovascular disease, cardiovascular risk factors, risk factor modification, global, population-attributable fraction, geographical comparison, myocardial infarction, coronary heart disease, stroke, heart disease