Er:YAG Laser for Treatment of Enlarged Pores

Study Overview
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Brief Summary
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To investigate the efficacy of Erbium:Yttrium aluminum garnet laser (Er:YAG) in the treatment of enlarged pores.

Detailed Description
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Enlarged pores are caused by multifactorial factors such as sex, genetics, aging, etc. The gold of the treatment is to recollagenesis of the dermis and resurfacing of the epidermis. Modalities that have been proved on their efficacy for enlarged pores treatment included topical retinoic acid, chemical peeling, intense pulsed light, radiofrequency device, laser such as Q-switched and Long Pulsed Neodymium-Doped Yttrium-Aluminum-Garnet (Nd:YAG) 1,064nm, Long pulse duration pulsed dye laser 595nm, etc. Er:YAG laser is an ablative laser which creates both recollagenesis and resurfacing. It ha been proved to be safe and effective in the treatment of atrophic acne scar. However, the efficacy of this laser for enlarged treatment has not yet been established.

Official Title
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The Efficacy and Safety of Erbium:Yttrium Aluminum Garnet Laser for Treatment of Enlarged Pores: A Pilot Study

Conditions
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Enlarged Pores

Intervention / Treatment
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* Device: Er:YAG laser


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Visible enlarged pores on both sides of the face Fitzpatrick skin type 3-5 Exclusion Criteria: Patients with lesions with any clinical suspicion of being pre-cancerous or skin malignancies of any kind Patients who have photosensitive dermatoses Pregnancy and lactation woman Patients with wound infections (herpes, other) on the day of treatment Patients with moderate and severe inflammatory acne, Immunosuppressed patients, history of vitiligo Patients with unrealistic concerns/expectations and inability to do the appropriate post-operative care

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Er:YAG laser<br>4 treatments of 1 month interval | Device: Er:YAG laser<br>* Er:YAG laser treats enlarged pores on both sides of the face for 4 treatments of 1 month interval.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The efficacy of Er:YAG laser in the treatment of enlarged pores (measurement of skin texture using UVA-light video camera) | measurement of skin texture using UVA-light video camera | 1 month after 4 treatments | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hyperpigmentation side effect of Er:YAG laser in the treatment of enlarged pores | By investigators' observation of hyperpigmentation | Follow-up period:1 month after 1st treatment, 1 month after 2nd treatment, 1 month after 3rd treatment and 1-,3-,and 6-month after 4th treatment | 
| Hypopigmentation side effect of Er:YAG laser in the treatment of enlarged pores | By investigators' observation of hypopigmentation | Follow-up period:1 month after 1st treatment, 1 month after 2nd treatment, 1 month after 3rd treatment and 1-,3-,and 6-month after 4th treatment | 
| Erythema side effect of Er:YAG laser in the treatment of enlarged pores | By investigators' observation of erythema | Follow-up period:1 month after 1st treatment, 1 month after 2nd treatment, 1 month after 3rd treatment and 1-,3-,and 6-month after 4th treatment | 
| The patients satisfaction using Quartile grading scale of improvement | By using Quartile grading scale of improvement; 0 = not improve, 1= 1-25% improvement, 2 = 26-50% improvement, 3 = 51-75% improvement and 4 = 76-100% improvement | Follow-up period:1 month after 1st treatment, 1 month after 2nd treatment, 1 month after 3rd treatment and 1-,3-,and 6-month after 4th treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Enlarged pores, Er:YAG laser