Long-term Sequelae of Childhood Meningitis and Meningococcal Purpura Fulminans

Study Overview
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Brief Summary
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While the initial evolution of meningococcal meningitis (MM) is well described, there are few data on the long-term evolution, beyond 1 year. The objective of this research is to evaluate the sequelae of MM beyond 1 year in patients with a history of MM followed in Paris area, France. Most children with MM in France have been included in the MM register and are still being followed. Parents will be offered a detailed clinical evaluation of their child including: a clinical and neurological examination, a cognitive performance assessment, an auditory, speech and visual assessment and an evaluation of the child's progress at school.

Official Title
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Long-term Sequelae of Childhood Meningitis and Meningococcal Purpura Fulminans in Ile de France: a Multidisciplinary Approach

Conditions
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Meningitis, Meningococcal, Sequela

Intervention / Treatment
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* Other: sequela evaluation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Infants and children from 0 to 17 years old Having had meningitis or meningococcal purpura fulminans between 2010 and 2021 Delay ≥ 1 year between the date of diagnosis of meningitis or purpura meningococcal fulminans and the date of inclusion in the study (signature of the informed consent) The holders of parental authority have read and understood the information letter and their express consent has been obtained Patient affiliated to a social security system (Social Security or Universal Medical Coverage) Exclusion Criteria: refusal to participate

Ages Eligible for Study
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Maximum Age: 17 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: sequela evaluation|clinical and neurological examination, psychological evaluation (cognitive performance), an auditory, speech and visual assessment and an evaluation of the child's school performance|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of children with at least one neurological, orthopedic or sensory sequelae |  | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of children with severe neurological sequelae |  | 1 year | 
| Number of children with orthopedic complications |  | 1 year | 
| Number of children with sensory disorders |  | 1 year | 
| Number of children with skin sequelae |  | 1 year | 
| Number of children with learning disabilities |  | 1 year | 
| Number of children with cognitive or psychological difficulties identified on the WPPSI, WISC V or VINELAND depending on their age and capacity | 95% of the population has a Total IQ between 70 and 130 (from low intelligence to high intelligence). | 1 year | 
| Number of consultations during follow-up |  | 1 year | 
| Post-traumatic stress in parents using the IES-R questionnaire | A score up to 33 is associated with a stress post traumatic | 1 year |