Phase II Proof-of-concept Study of APD421

Study Overview
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Brief Summary
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Evaluation of efficacy of APD421 in preventing nausea and vomiting caused by cisplatin

Official Title
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Open-label, Ascending-dose, Phase II Study to Determine the Minimum Effective Dose of APD421 in the Prevention of Cisplatin-induced Nausea and Vomiting

Conditions
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Chemotherapy-induced Nausea and Vomiting

Intervention / Treatment
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* Drug: APD421


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male or female patients ≥ 18 years of age Ability and willingness to give written informed consent Patients scheduled to receive, on day 1 of their chemotherapy, a first cisplatin chemotherapy infusion at a dose of 50 mg/m2 or greater Karnofsky performance score ≥ 60% Adequate cardiac, hepatic and renal function QTc interval < 500 ms Alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) < 5 x upper limit normal (ULN) Bilirubin < 3 x ULN Creatinine < 2 x ULN Adequate haematological function Haemoglobin ≥ 9 g/dL White blood count ≥ 3.0 x 109/L Platelet count ≥ 100 x 109/L For females of child-bearing potential: ability and willingness to use a highly effective form of contraception (e.g., abstinence from sexual intercourse, surgical sterilisation (of subject or partner) or a double-barrier method of contraception such as either an intra-uterine device (IUD) or an occlusive cap with spermicide, in conjunction with partner's use of a condom) during the study and for a period of at least 48 hours afterwards. Exclusion Criteria: Patients scheduled to receive, prior to or in the 24 hours after cisplatin, any chemotherapeutic agent with a high or moderate emetic risk, see Appendix 4. Patients scheduled to receive paclitaxel or docetaxel Patients undergoing abdominal or pelvic irradiation within 48 hours prior to screening or scheduled to receive abdominal or pelvic irradiation between screening and 24 hours after cisplatin administration Patients receiving APD421 for any indication within the last 2 weeks Patients who are allergic to APD421 or any of the excipients of APD421 Patients with a pre-existing vestibular disorder Patients being treated with regular anti-emetic therapy including corticosteroids Patients receiving inhaled corticosteroids, unless started more than one month prior to the expected date of study entry Patients being treated with medications which could induce torsades de pointes, including Class Ia antiarrhythmic agents such as quinidine, disopyramide, procainamide; Class III antiarrhythmic agents such as amiodarone and sotalol; and other medications such as bepridil, cisapride, thioridazine, methadone, IV erythromycin, IV vincamine, halofantrine, pentamidine, sparfloxacin Patients being treated with xxx Patients receiving benzodiazepines, unless on a stable dose for at least one month prior to the expected date of study entry Patients with pre-existing nausea or vomiting in the 24 hours before receiving cisplatin chemotherapy, e.g. anticipatory emesis Patients who are pregnant or breast feeding Patients with a history of alcohol abuse Patients with pre-existing, clinically significant cardiac arrhythmia Any other concurrent disease or illness that, in the opinion of the investigator makes the patient unsuitable for the study Patients who have participated in another study within the previous 28 days

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: APD421 starting dose<br> | Drug: APD421<br>* Single dose<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complete Response | No emesis or use of rescue medication | 24 hours after cisplatin dosing |