Laboratory Smoking of Marijuana Blunts

Study Overview
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Brief Summary
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This is a double-blind within-subjects clinical laboratory study comparing the product appeal and abuse liability-related subjective effects of different flavored cigar wrappers for marijuana blunts.

Official Title
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Laboratory Smoking of Marijuana Blunts

Conditions
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Cannabis

Intervention / Treatment
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* Drug: Marijuana


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Currently living in Baltimore City or Baltimore County, MD; Able to read, understand, and sign informed consent; 18-55 years old; Currently smokes marijuana blunts; Designation of Medically Healthy for Research by the Study Physician; and Willing to abstain from illicit drug use other than marijuana for the duration of the study. Exclusion Criteria: BAC > 0.020% as measured by alcohol breathalyzer; Meets DSM-5 criteria for severe current or lifetime Cannabis Use Disorder; Meets DSM-5 criteria for any current Axis I disorder, other than current mild or moderate Cannabis Use Disorder; Self-reported current desire to stop marijuana use; Self-reported current asthma, chronic obstructive pulmonary disease, hypertension, cardiovascular disease or any other medical illness that precludes participation; Has difficulties with blood draws or poor venous access; History of blood donation in the past 30 days or receiving blood products within the past 2 months prior to any experimental visit; Among females, current pregnancy or lactation or attempting to get pregnant, or at risk of becoming pregnant; Acute illness which will require participant to be rescheduled

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Flavor 1<br>Grape flavored tobacco cigar wrapper | Drug: Marijuana<br>* Marijuana smoked via blunts with different cigar wrappers<br>|
| Experimental: Flavor 2<br>Chocolate flavored tobacco cigar wrapper | Drug: Marijuana<br>* Marijuana smoked via blunts with different cigar wrappers<br>|
| Experimental: Flavor 3<br>Tobacco flavored tobacco cigar wrapper | Drug: Marijuana<br>* Marijuana smoked via blunts with different cigar wrappers<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Puff topography | Total inhalation volume | During marijuana blunt smoking | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Carbon monoxide | Exhaled breath carbon monoxide (ppm) | Immediately after marijuana blunt smoking | 
| Subjective drug effects | Ratings of good and high | Immediately after marijuana blunt smoking | 
| Measures of demand | Number of units an individual would purchase at varying price points | Immediately after marijuana blunt smoking | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cannabis