linjc16/ctgov huggingface dataset:
Prevalence of Circulating Parvovirus Genome in Recently Diagnosed Graves' Disease: a Case-control Study

Study Overview
=================
Brief Summary
-----------------
Lymphocytic thyroiditis is the most common autoimmune disease, usually affecting young women. Although the aetiology and pathogenesis remain obscure, the most widely accepted hypothesis is an interaction between a genetic predisposition and an environmental trigger factor such as viral infection. Parvovirus infections have been proposed as trigger factors for Hashimoto's thyroiditis and Graves' disease.

Official Title
-----------------
Prevalence of Circulating Parvovirus Genome in Recently Diagnosed Graves' Disease: a Case-control Study

Conditions
-----------------
Graves Disease

Intervention / Treatment
-----------------
* Biological: serodiagnosis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Graves' disease :patients treated for Graves' disease, the diagnosis date less than 4 months Control : patients cared for nodules or goiter Exclusion Criteria: Patients undergoing immunosuppressive therapy including corticosteroids

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Control<br>patients with goiter or nodule | Biological: serodiagnosis<br> <br> |
| Experimental: Graves' disease<br>patients with Graves' disease | Biological: serodiagnosis<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prevalence of circulating parvovirus genome |  | Day 0 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
parvovirus genome
Multi-center Study on Therapy-oriented Molecular Subtyping of Hepatocellular Carcinoma

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to establish molecular subtyping of HCC.

Detailed Description
-----------------
Hepatocellular carcinoma is one of the most common malignant tumors in the world with high incidence and mortality. Liver transplantation is the most effective treatment for HCC and is in high demand in China. However, recurrence of HCC among liver transplantation recipients is still a great challenge and threat to the survival of recipients. So it is of great significance to establish molecular subtyping of HCC and achieve precise selection of recipients. Based on large scales of samples, the investigator's study aims to establish multi-omics characteristic profiles of liver transplantation for HCC in integration of apparent biological characteristics, clinical management and prognostic information by utilizing genomics, transcriptomics and proteomics, etc. This study will contribute to the therapy-oriented molecular subtyping of HCC.

Official Title
-----------------
Multi-center Study on Therapy-oriented Molecular Subtyping of Hepatocellular Carcinoma

Conditions
-----------------
Hepatocellular Carcinoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Liver transplantation due to HCC within Hangzhou criteria Exclusion Criteria: Liver transplantation due to HCC beyond Hangzhou criteria Liver transplantation due to other disease except HCC Multiple organ transplantation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| recurrent HCC<br>recurrent HCC after LT | |
| non-recurrent HCC<br>non- recurrent HCC after LT | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| recurrence rate |  | 2 years |
Evaluation of Cytokine Biomarkers in Melanoma Patients During Immunotherapy

Study Overview
=================
Brief Summary
-----------------
Open prospective clinical trial to develop the computer software (Intelligent prognostic system) for predicting the efficacy of anti-PD-1 immunotherapy of melanoma patients in routine practice

Official Title
-----------------
Open Prospective Clinical Trial to Develop the Computer Software (Intelligent Prognostic System) for Predicting the Efficacy of Anti-PD-1 Immunotherapy of Melanoma Patients in Routine Practice

Conditions
-----------------
Melanoma

Intervention / Treatment
-----------------
* Drug: Anti-PD-1 monoclonal antibody


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Morphological verification of cutaneous melanoma. Verification of metastases is not necessary ECOG 0-1 Age of patients - 18 years and older No prior chemotherapy, immunotherapy, radiation or hormonal therapy Adequate contraception for women of childbearing age Written consent of the patient to participate in the study Exclusion Criteria: Non-compliance with the previously listed criteria Pregnancy and breastfeeding Therapy with systemic corticosteroids and/or other immunosuppressants within 4 weeks before the screening or a high probability of the need for their use during the study for the treatment of intercurrent pathology History of another malignancy other than the study indication under this trial within 5 years of study enrollment. Does not apply to subjects who underwent successful definitive resection of basal or squamous cell carcinoma of the skin, in situ cervical cancer, in situ breast cancer, or other in situ cancers.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Advanced melanoma patients<br> | Drug: Anti-PD-1 monoclonal antibody<br>* Anti-PD-1 therapy<br>|
| Other: Stage III and IV melanoma patients after radical surgery<br> | Drug: Anti-PD-1 monoclonal antibody<br>* Anti-PD-1 therapy<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall survival |  | up to 12 months | 
| Progression free survival |  | up to 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cytokine profile | IL-2, IL-6, IL-7, IL-8, IL-10, IL-12p70, IL-22, (IFN)-α2, IFN-γ, NFβ/Lymphotoxin-α(LTA), MCP-1/CCL2,IP-10/CXCL10, MIG/CXCL9, GM-CSF, PDGF-AA, PDGF-AB/BB, VEGF-A | up to 12 months |
Distances From Cricoid Cartilage to the Targets of Stellate Ganglion Block

Study Overview
=================
Brief Summary
-----------------
Stellate ganglion block targets are C6 transverse process or C7 transverse process in anterior paratracheal approach which is most popular method. Cricoid cartilage is known that it is located at C6 level in supine neutral position of the neck. But stellate ganglion block is performed in supine extended position of the neck. So cricoid cartilage will move up to cephalad direction and pain doctors should find C6 or C7 transverse process at lower neck area than cricoid cartilage.

Official Title
-----------------
Distances From Cricoid Cartilage to the Targets of Stellate Ganglion Block

Conditions
-----------------
Herpes Zoster, CRPS

Intervention / Treatment
-----------------
* Other: supine extended position of the neck


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: adults above age of 20 reserved for musculoskeletal ultrasonography Exclusion Criteria: past history of neck surgery the limitation of neck motion due to rheumatoid arthritis, et al. severe neck pain inability to communicate or read or write

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: neck extended group<br>We measured the distances from cricoid cartilage to C6 or C7 transverse process in supine neutral and extended position of the neck. | Other: supine extended position of the neck<br>* we measure the distances from cricoid cartilage to C6 or C7 transverse process in supine neutral and extended position of the neck<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the distances from cricoid cartilage to C6, C7 transverse process in supine neutral and extended position of the neck | The distances from cricoid cartilage to C6, C7 transverse process will be measured in supine neural position and extended position of the neck up to 1 week after agreement to enroll | up to 1 week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the sexual difference in the distances from cricoid cartilage to C6, C7 transverse process in supine neutral or extended position of the neck | The sexual difference in the distances from cricoid cartilage to C6,C7 transverse process will be measured in supine neural position and extended position of the neck up to 1 week after agreement to enroll | up to 1 week |
Influence of Preoperative Enema Application on Return of Gastrointestinal Function After Elective Cesarean Section: A Randomized Controlled Study

Study Overview
=================
Brief Summary
-----------------
The researchers investigate that use of preoperative enema to the effect postoperative bowel gas passage.

Conditions
-----------------
Postoperative Bowel Sounds, Bowel Gass Passage

Intervention / Treatment
-----------------
* Drug: Fleet enema


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: elective cesarean no history of previous abdominal operation(except cs) Exclusion Criteria: Emergency cesarean delivery Refusal to participate.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 44 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Fleet enema|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
caesarean, bowel, gass
Blood Pressure Change and Outcome

Study Overview
=================
Brief Summary
-----------------
Hyper- and hypotension are important predictors of survival in non-ESRD (end stage renal disease) population. In dialysis patients, however, it has been shown that higher blood pressure levels may actually be beneficial to patient outcomes. Dynamics of blood pressure evolution over time has not been previously studied in dialysis population. The investigators aim to understand how both blood pressure levels and blood pressure changes over time predict patient survival.

Official Title
-----------------
The Relationship of Systolic and Diastolic Blood Pressure Changes Over Time to Patient Outcomes in Incident Hemodialysis Patients

Conditions
-----------------
Renal Disease, High Blood Pressure

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Hemodialysis

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 88 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hemodialysis patients<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect size of the relation of dynamic changes of blood pressure (BP) at different ranges of BP to survival in incident hemodialysis patients. | The ranges of blood pressure measurements in mmHg over time and the relation to patient outcomes (including survival) | Up to 11 years and 11 months |
Interest of Medical Imaging in the Diagnostic Strategy Vis a Vis a Suspected Horton Disease

Study Overview
=================
Brief Summary
-----------------
The study aims at measuring the sensitivity and specificity of a series of imaging signs (recorded by magnetic resonance angiography, vascular tomodensitometry, vascular ultrasonography, retina angiography and retina optic coherence tomography) for the diagnosis of Horton disease, the gold standard being the result of temporal artery biopsy.

Conditions
-----------------
Horton Disease

Intervention / Treatment
-----------------
* Radiation: Vascular tomodensitometry
* Other: Magnetic resonance angiography
* Other: Vascular ultrasonography
* Other: Retinal angiography
* Other: Retinal optical coherence tomography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients admitted to the Fondation Ophtalmologique Adolphe de Rothschild and suspected to suffer from Horton disease, based on the presence of 3 or more major criteria, or 2 major criteria and at least one minor criteria. Major criteria : Age > 50 ans ; headache ; intermittent jaw or tongue pain ; visual impairment ; ESR > 50 mm at 1h and/or CRP > 8mg/l. Minor criteria: temporal artery or scalp tenderness ; facial pain or tenderness ; fever >38°C, weight loss >10%, anorexia, fatigue. Exclusion Criteria: Autoimmune disease Active infectious condition Malignant disease Condition counterindicating one or several of the protocol's imaging procedures : allergy to iodine and/or renal insufficiency and/or claustrophobia and/or metallic foreign body...

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cases<br>Patients admitted to a tertiary hospital, with a clinical suspicion of Horton disease | Radiation: Vascular tomodensitometry<br> <br> Other: Magnetic resonance angiography<br> <br> Other: Vascular ultrasonography<br> <br> Other: Retinal angiography<br> <br> Other: Retinal optical coherence tomography<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MRI angiography mural inflammation | Presence of signs of artery mural inflammation in T1 sequence of MRI angiography | Baseline |
The Results of Pancreatic Operations After the Implementation of Multidisciplinary Team Conference (MDT):

Study Overview
=================
Brief Summary
-----------------
Background: Centralization has improved the outcome of complex operations including cancer surgery. Moreover, the implementation of multidisciplinary team conferences (MDT) has ameliorated the decision making, but the impact on patient outcome is controversial. The aim of the study was to investigate the outcome of pancreatic surgery in the setting of centralization and upfront multidisciplinary decision making.

Detailed Description
-----------------
Study is a retrospective register study from a prospective database over MDT conferences and patient outcome. End points are quality evaluation regarding postoperative complications and mortality and long-term survival of patients radically operated for pancreatic cancer.

Official Title
-----------------
The Results of Pancreatic Operations After the Implementation of Multidisciplinary Team Conference (MDT): A Quality Improvement Study

Conditions
-----------------
Pancreatic Neoplasms

Intervention / Treatment
-----------------
* Other: number of participants with surgical complications


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: all gender seen at multidisciplinary team conference (MDT) Exclusion criteria: all gender not seen at MDT - -

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 86 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| MDT conference<br>participants evaluated at MDT conference | Other: number of participants with surgical complications<br>* observation before and after multidisplinary team conference (MDT) was implemented<br>* Other names: number of participants surviving months;|
| no MDT conference<br>participants not evaluated at MDT conference | Other: number of participants with surgical complications<br>* observation before and after multidisplinary team conference (MDT) was implemented<br>* Other names: number of participants surviving months;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| complications following pancreatic surgery | study from clinical database | 14 years | 
| survival following pancreatic surgery | study from clinical database | 14 years |
Potential of Deep Learning in Assessing Pneumoconiosis Depicted on Digital Chest Radiography

Study Overview
=================
Brief Summary
-----------------
Pneumoconiosis is relatively prevalent in low/middle-income countries, and it remains a challenging task to accurately and reliably diagnose pneumoconiosis. The investigators implemented a deep learning solution and clarified the potential of deep learning in pneumoconiosis diagnosis by comparing its performance with two certified radiologists. The deep learning demonstrated a unique potential in classifying pneumoconiosis.

Detailed Description
-----------------
The investigators retrospectively collected a dataset consisting of 1881 chest X-ray images in the form of digital radiography. These images were acquired in a screening setting on subjects who had a history of working in an environment that exposed them to harmful dust. Among these subjects, 923 were diagnosed with pneumoconiosis, and 958 were normal. To identify the subjects with pneumoconiosis, the investigators applied a classical deep convolutional neural network (CNN) called Inception-V3 to these image sets and validated the classification performance of the trained models using the area under the receiver operating characteristic curve (AUC).

Official Title
-----------------
Investigate the Potential of Deep Learning in Assessing Pneumoconiosis Depicted on Digital Chest Radiographs and to Compare Its Performance With Certified Radiologists

Conditions
-----------------
Pneumoconiosis

Intervention / Treatment
-----------------
* Other: convolutional neural networks (CNNs)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: industrial workers with a history of exposure to dust and underwent DR screening of pneumoconiosis from 2015 to 2018 Exclusion Criteria: patients with poor image quality patients with incomplete clinical data
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| convolutional neural network (CNN)<br>a classical deep convolutional neural network (CNN) called Inception-V3 was applied to the image sets and validated the classification performance of the trained models | Other: convolutional neural networks (CNNs)<br>* CNN architecture named U-Net architecture<br>* Other names: deep learning technology;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the diagnosis of pneumoconiosis | The diagnosis and staging of pneumoconiosis were made by an expert panel consisting of certified radiologists and occupational physicians. The diagnosis of pneumoconiosis was confirmed by medical history and previous medical records(chest X-rays and pulmonary function testing). | up to 6 months |