The Mechanism for the Effects of Joint Biomechanical Properties on Medial Cartilage of Tibiofemoral Joint Degeneration

Study Overview
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Brief Summary
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Explore The Mechanism for the Effects of Joint Biomechanical Properties on Medial Cartilage of Tibiofemoral Joint Degeneration

Detailed Description
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Cartilage degeneration in the medial tibiofemoral joint is common after anterior cruciate ligament reconstruction (ACLR), which may develop into knee osteoarthritis (disability rate 21.3%). Alterations in joint biomechanical properties play an important role in cartilage degeneration after ACLR. However, the mechanism remains unclear. Our research studied the joint kinematics and kinetics properties after ACLR and found significant changes in biomechanics in the ACLR knees. Therefore, this study will combine longitude biochemical changes in the cartilage to explore how the alterations in biomechanics would influence biochemical changes in the joint cartilage. This study will explore the joint biomechanical properties during functional activities by motion analysis, the effects of biomechanical properties on cartilage stress distribution by finite element analysis, the long-term biochemical changes in the joint cartilage by functional MRI. This study will establish prediction models for cartilage biomechanical changes in the mid-term based on joint biomechanical properties in the early stage after ACLR, and cartilage biomechanical changes in the long-term based on joint biomechanical properties in the mid-term after ACLR. The study aims to clarify the mechanism of cartilage degeneration after ACLR and search biomechanical risk factors, in order to provide methods for clinical prevention of cartilage degeneration after ACLR.

Official Title
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The Mechanism for the Effects of Joint Biomechanical Properties on Medial Cartilage of Tibiofemoral Joint Degeneration

Conditions
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Anterior Cruciate Ligament Injuries, Cartilage Degeneration

Intervention / Treatment
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* Diagnostic Test: gait testing, functional MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Unilateral ACL rupture of the knee Exclusion Criteria: concomitant with other ligament injury or rupture, with history of surgery or musculoskeletal system injury of the contralateral knee, and the time from injury to operation more than 8 weeks
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| healthy volunteers<br>gait testing and MRI at baseline for healthy volunteers | Diagnostic Test: gait testing, functional MRI<br>* diagnostic tests including the gait testing and functional MRI<br>|
| ACL-deficient patients<br>gait testing and MRI at pre-operation, 6 months post-operation, 1 year post-operation, 2 years post-operation | Diagnostic Test: gait testing, functional MRI<br>* diagnostic tests including the gait testing and functional MRI<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| knee T1 rho value | knee T1 rho value by functional MRI | On the day of enrollment. | 
| knee T1 rho value | knee T1 rho value by functional MRI | At 6 months post operation. | 
| knee T1 rho value | knee T1 rho value by functional MRI | At 12 months post operation. | 
| knee T1 rho value | knee T1 rho value by functional MRI | At 2 years post operation. | 
| knee T2 value | knee T1 rho value by functional MRI | On the day of enrollment. | 
| knee T2 value | knee T1 rho value by functional MRI | At 6 months post operation. | 
| knee T2 value | knee T1 rho value by functional MRI | At 12 months post operation. | 
| knee T2 value | knee T1 rho value by functional MRI | At 2 years post operation. | 
| knee extension angles | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | On the day of enrollment. | 
| knee extension angles | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 6 months post operation. | 
| knee extension angles | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 12 months post operation. | 
| knee extension angles | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 2 years post operation. | 
| knee moments | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | On the day of enrollment. | 
| knee moments | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 6 months post operation. | 
| knee moments | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 12 months post operation. | 
| knee moments | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 2 years post operation. | 
| ground reaction force | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | On the day of enrollment. | 
| ground reaction force | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 6 months post operation. | 
| ground reaction force | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 12 months post operation. | 
| ground reaction force | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 2 years post operation. | 
| knee rotation angles | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | On the day of enrollment. | 
| knee rotation angles | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 6 months post operation. | 
| knee rotation angles | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 12 months post operation. | 
| knee rotation angles | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 2 years post operation. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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sports biomechanics, joint loading, anterior cruciate ligament reconstruction, cartilage degeneration, functional MRI