Coronary Anatomy Study and Times Since the Onset of Acute Myocardial Infarction Symptoms in Women Until the Opening of the Artery (TAPAC Study)

Study Overview
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Brief Summary
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TAPAC study is an an investigator-driven, observational, prospective,cohort aimed at evaluating differences between men and women in patients undergoing primary angioplasty : hospital medical care, successful markers myocardial reperfusion and the anatomical substrate by describing the underlying coronary anatomy will be compared.

Detailed Description
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TAPAC study is an an investigator-driven, observational, prospective,cohort aimed at evaluating differences between men and women in patients undergoing primary angioplasty : hospital medical care, successful markers myocardial reperfusion and the anatomical substrate by describing the underlying coronary anatomy will be compared.

Official Title
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Coronary Anatomy Study and Times Since the Onset of Acute MyocardiaI Infarction Symptoms in Women Until the Opening of the Artery (TAPAC Study)

Conditions
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Myocardial Infarction

Intervention / Treatment
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* Other: Non intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with: Aged 18 years or over. AMI (Acute Mycardial Infarction ) with ST segment elevation and indication of primary angioplasty in whom at least one diagnostic procedure with coronary angiography is performed. Exclusion Criteria: Patients with: Life expectancy of less than one year. Previous AMI. Previous coronary revascularization.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Women patients<br>Women patients | Other: Non intervention<br>* Non intervention<br>|
| Men patients<br>Men patients | Other: Non intervention<br>* Non intervention<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Door-to-balloon time in patients | Door-to-balloon time in patients | 90 minutes | 
| Door-to-needle time in patients | Door-to-balloon time in patients | 90 minutes | 
| Time from onset of chest pain to first medical care | Time from onset of chest pain to first medical care | 24 hours | 
| Time from onset of chest pain to arrival Cath Lab | Time from onset of chest pain to arrival Cath Lab | 24 hours | 
| Time from onset of chest pain to artery opening | Time from onset of chest pain to artery opening | 24 hours | 
| Markers successful myocardial reperfusion by angiography | ST segment resolution 90 minutes post-PCI (Percutaneous Coronary Intervention) | First 90 min after reperfusion. | 
| Markers successful myocardial reperfusion by angiography | Final TIMI (Thrombolysis in Myocardial Infarction) flow grade | First 90 min after reperfusion. | 
| Markers successful myocardial reperfusion by angiography | Final TIMI blush grade | First 90 min after reperfusion. | 
| Underlying coronary anatomy assessment | Final TIMI Thrombus grade | 24 hours | 
| Underlying coronary anatomy assessment | Degree of difuse disease | 24 hours | 
| Underlying coronary anatomy assessment | Number of vessels involve | 24 hours | 
| Underlying coronary anatomy assessment | Percentage of Ventricular Ejection Fraction | 24 hours | 
| Underlying coronary anatomy assessment | Presence of significant Left Main disease | 24 hours | 
| Underlying coronary anatomy assessment | Degree of distal embolization | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Major adverse cardiac events (MACE) | MACE rate during hospitalization, defined as death, non-fatal myocardial rupture, or appearance or worsening of heart failure during the hospitalization period and after 1 year of follow-up | Hospital discharge and expected average of 1 week, one year follow-up | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Acute Coronary Syndrome, Primary Angioplasty, Gender