Sarcopenia After Bariatric Surgery in Older Patients: A Cohort Study

Study Overview
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Brief Summary
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The retrospective cohort study will compare the prevalence of sarcopenia and associated factors between older patients who have undergone bariatric surgery and older patients with obesity without previous bariatric surgery.

Detailed Description
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The aim of the study is to compare the prevalence of sarcopenia and nutritional status between adults older than 65 years who have previously undergone bariatric surgery and patients with obesity but without previous bariatric surgery. Current sarcopenia will be assessed during a cross-sectional assessment after surgery using the criteria from the European Working Group on Sarcopenia in Older People (EWGSOP).

Official Title
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Sarcopenia After Bariatric Surgery in Older Patients: A Cohort Study

Conditions
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Overweight and Obesity, Bariatric Surgery, Aging, Sarcopenic Obesity

Intervention / Treatment
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* Procedure: Bariatric surgery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Signed informed consent Age 65 years or older Cohort 1 (exposed): Previous bariatric surgery for obesity at least 1 one year ago Cohort 2 (unexposed): No previous weight loss surgery Exclusion Criteria: Current diagnosis of cancer Advanced organ failure, including chronic kidney disease Stage 5, liver cirrhosis Stage 3, intestinal failure, heart failure stage D, or chronic obstructive pulmonary disease stage 4. Immobility Neuromuscular degenerative conditions

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cohort 1<br>Cohort 1: Older patients with overweight, obesity after bariatric surgery | Procedure: Bariatric surgery<br>* Bariatric surgery<br>|
| Cohort 2<br>Cohort 2: Older patients with overweight, obesity without bariatric surgery | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The number of older patients with sarcopenia after bariatric surgery compared to non-surgical control patients. | a) Sarcopenia will be classified according to the criteria form the European Working Group on Sarcopenia in Older People revised guidelines (EWGSOP2) based on skeletal muscle mass, muscle strength and physical performance criteria. | At least one year post surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 1. Appendicular skeletal muscle mass older of patients after bariatric surgery compared to non-surgical control patients | 1. Appendicular skeletal muscle mass older of patients after bariatric surgery compared to non-surgical control patients | At least one year post surgery | 
| 2. The prevalence of nutrient deficiencies in older patients after bariatric surgery compared to non-surgical control patients. | a. Indices of nutrient deficiencies will include reported dietary intake of protein, zinc, selenium, and blood levels of Vitamin D, zinc, and selenium. | At least one year post surgery | 
| 3. Markers of chronic systemic inflammation in older patients after bariatric surgery compared to non-surgical control patients | Inflammatory markers will include CRP, IL-1β, IL-6, IL-8, TNF-α | At least one year post surgery |