linjc16/ctgov huggingface dataset:
Upper Gastrointestinal Lesions in Crohn's Disease

Study Overview
=================
Brief Summary
-----------------
A cross-sectional study was performed from 2017 to 2018. Consecutive Crohn's disease patients diagnosed in the Inflammatory bowel disease center of the Sixth Affiliated Hospital of Sun Yat-sen University were recruited. All patients underwent upper gastrointestinal endoscopy and biopsy by two defined endoscopists and two pathologists, the basic information were collected at the same time, in order to assess the prevalence of upper gastrointestinal involvement, and determine the role of upper gastrointestinal endoscopy in adult Crohn's disease patients, irrespective of upper gastrointestinal symptoms.

Official Title
-----------------
Upper Gastrointestinal Lesions in Crohn's Disease: a Cross-sectional Cohort Study

Conditions
-----------------
Crohn's Disease, Upper Gastrointestinal Lesions

Intervention / Treatment
-----------------
* Other: gastroscopy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age is 18 years old or older patients with diagnosis of Crohn's disease Exclusion Criteria: diagnostic data were incomplete patients with malignant tumor use of PPIs or non-steroidal anti-inflammatory drugs in the preceding 4 weeks

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Intervention Model: Sequential Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: adult patients with Crohn's disease<br>All adult patients(18 years old or older) with Crohn's disease underwent gastroscopy; patients with diagnosed and treated Crohn's disease had gastroscopy performed during the re-examination, and patients diagnosed with Crohn's disease for the first time had gastroscopy performed during the initial consultation. | Other: gastroscopy<br>* Two endoscopists performed upper gastrointestinal endoscopy and biopsy on all patients; and histological review was performed by two pathologists. From each patient, 10 specimens were taken from 6 areas in the upper gastrointestinal tract and basic informations was collected.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the incidence of different upper gastrointestinal lesions | The incidence of different characteristic lesions of upper gastrointestinal in CD patients. | 1 year |
Subjective Effects of Nitrous Oxide in Dental Patients - 17

Study Overview
=================
Brief Summary
-----------------
The purpose of this study was to characterize mood changes during nitrous oxide inhalation in patients with different levels of preoperative dental anxiety.

Official Title
-----------------
Subjective Effects of Nitrous Oxide in Dental Patients

Conditions
-----------------
Opioid-Related Disorders, Substance-Related Disorders

Participation Criteria
=================
Eligibility Criteria
-----------------
Please contact site for information.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Low anxiety<br> | |
| Moderate anxiety<br> | |
| High anxiety<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anxiety scale |  | Before, during, after dental procedure | 
| Mood scale |  | Before, during, after dental procedure | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
nitrous oxide, anxiety, subjective effects, dental, patients
A Retrospective Analysis of Patients With Full Thickness Wounds on a Case by Case Basis

Study Overview
=================
Brief Summary
-----------------
To demonstrate the effectiveness or ineffectiveness of novel treating agents or agents used for compassionate rescue, subjects and their wounds will be analyzed retrospectively and their non-identifiable information will be compiled in the form of case studies. Subjects who demonstrated characteristics of interest (e.g. healing) as determined by the PI will be chosen for case studies.

Detailed Description
-----------------
All wounds at the Southwest Regional Wound Care Center (WCC) are managed using anti-biofilm strategies. When determining the therapeutic course for a patient and his full thickness wound, all management agents that are available are considered for use; and the clinician uses his judgment to determine the most appropriate tools to use that will give the patient the most likely chance of success. Some of the agents that are used are novel, and it is appropriate to demonstrate to others the potential usefulness of these agents

Official Title
-----------------
A Retrospective Analysis of Patients With Full Thickness Wounds on a Case by Case Basis

Conditions
-----------------
Full Thickness Wounds

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male or female > 18 years old Retrospective analysis

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Anaysis of Full Thickness wounds<br>To demonstrate the effectiveness or ineffectiveness of novel treating agents or agents used for compassionate rescue, subjects and their wounds will be analyzed retrospectively and their non-identifiable information will be compiled in the form of case studies. Subjects who demonstrated characteristics of interest (e.g. healing) as determined by the PI will be chosen for case studies. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Retrospective Analysis of Patients with Full Thickness Wounds |  | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
full Thickness wounds
New Critical Thinking in Physiotherapy Clinical Practice Questionnaire

Study Overview
=================
Brief Summary
-----------------
A greater need for user-centered care and an evidence-based clinical practice are factors that emphasize critical thinking as a professional competence. Furthermore, critical thinking is an essential competence that allows clinical reasoning, problem solving and decision-making in the critical clinical practice of all specializations in Physiotherapy. However, no instrument has been found that specifically assesses the critical thinking of physiotherapists in their clinical practice.

Detailed Description
-----------------
Multicenter, descriptive, cross-sectional and correlational study in two phases. Phase 1: adaptation of the N-CT-4P to the population of physiotherapists; Phase 2: analysis of the psychometric properties of the new instrument and levels of critical thinking through a cross-sectional study. Sociodemographic and professional variables and variables referring to the measurement of critical thinking (total score of the questionnaire and of each of its dimensions) will be collected. Its psychometric properties, internal consistency, repeatability analysis, discriminant validity and construct validity will be analyzed through confirmatory factor analysis and a multiple regression analysis will be performed.

Official Title
-----------------
Adaptation and Validation of the New Critical Thinking in Physiotherapy Clinical Practice Questionnaire: Multicenter Study

Conditions
-----------------
Critical Thinking

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Be a Graduate, Diploma or Bachelor of Physiotherapy Have an employment contract, as a care physiotherapist at the time of answering the questionnaire. Exclusion Criteria: Have a contractual continuity of less than 15 days.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 67 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To validate in the physiotherapist population the instrument Nursing Critical Thinking in Clinical Practice Questionnaire (N-CT-4 Practice) in its version New Critical Thinking in Physiotherapy Clinical Practice Questionnaire (N-CT-4 Physiotherapy). |  | The questionnaire will be self-administered and the estimated response time is less than 15 minutes. |
Effects of a Breakfast and Snack on Cognitive Function in Preadolescents

Study Overview
=================
Brief Summary
-----------------
This study is designed to test how breakfast affects brain function, memory and learning in healthy children. Hypotheses: Based on the results of our initial study and the relevant literature, it is hypothesized that arousal, attention, and performance will be: Greater in those who eat breakfast relative to those who do not; Greater in lean than in overweight children receiving the higher protein breakfast; Greater in fasting lean than fasting overweight children; and Improved following a morning snack in all study groups. Poorer in children with higher stress-related measures (e.g., higher cortisol levels). Heart rate will be lower in fasting relative to fed participants, and across groups will be higher in overweight children.

Conditions
-----------------
Brain Function

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy attending 4th or 5th grade lean BMI or overweight BMI right hand dominance no food allergies eat breakfast at least 4 mornings/week no medications for chronic illness/disorder that may affect outcome (as determined by the PI) Exclusion Criteria: food allergies medications that could affect the outcome left hand dominance

Ages Eligible for Study
-----------------
Minimum Age: 9 Years
Maximum Age: 11 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Lean BMI<br>BMI in the 25th - 75th percentile | |
| Overweight BMI<br>BMI in the 85th - 95th percentile | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
First Impressions and Attractiveness Levels of Smiling Individuals With and Without a Mask

Study Overview
=================
Brief Summary
-----------------
Evaluation on the effects of smiling on first impressions and attractiveness with and without wearing a facial surgical mask.

Official Title
-----------------
The Influence of a Mask on the First Impressions Projected and Attractiveness Levels of Smiling Individuals

Conditions
-----------------
First Impressions, Attractiveness

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Models who are males and females of ages 21-39. Live and random raters who are males and females of ages 18-39. Models and raters that understand the purpose and aspects of the study, freely sign the consent and complete the required visit. Models and raters must all be able to understand English fluently. Exclusion Criteria: Model participants younger than 21 or older than 40 will not be included. Live and random rater participants younger than 18 and older than 40 will not be included. Models with unusual hair styles or colors Facial piercing other than ears Facial and/or neck scaring or tattooing Models and raters that do not understand the purpose and aspects of the study, do not sign the consent and do not complete the required visit will also be excluded.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 39 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To evaluate the effects of smiling on first impressions with and without wearing a mask | First impression questionnaire (FIQ) | 8 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
attractiveness, first impressions, smiling, mask, masking, rating
Dual-energy CT in Detecting Bone Marrow Edema of Vertebral Compression Fractures

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to Assess bone marrow edema within the VCF by use of a DE CT virtual noncalcium image compared with MR imaging as standard reference. Evaluate parameters related to the BME of the collapsed vertebral body on DE CT virtual noncalcium images, such as the morphologic signs, visual qualitative detection, and quantitative values.

Detailed Description
-----------------
Patients with multiple compression fractures and in those with chronic fracture, determining which vertebra to treat is frequently difficult. In such patients, the treatment location is commonly determined from findings at imaging, which includes magnetic resonance (MR) imaging, bone scintigraphy, and computed tomography (CT). The bone marrow edema (BME) in acute/subacute VCFs is useful in determining the vertebra that is to be treated. MR imaging provides information on anatomic vertebral collapse and the loss of normal T1 high signal intensity from the marrow space of vertebrae with acute fractures. Loss of normal T1 high signal intensity indicates the presence of BME, which is the important sign for the PVP treatment of VCFs. Dual-energy (DE) CT has been used to create a virtual unenhanced scan by subtracting iodine from contrast agent-enhanced CT examinations.We expect that the same technique can be used to calculate a virtual noncalcium image from an unenhanced image, which makes bone marrow accessible for CT diagnosis.

Official Title
-----------------
Use of Dual-energy CT in Detecting Bone Marrow Edema of Vertebral Compression Fractures

Conditions
-----------------
Compression Fracture of Thoracic Vertebral Body, Spinal Compression Fracture

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Compression fractures (thoracic and lumbar vertebrae) Exclusion Criteria: Age less than 18 years Pregnancy Any contraindications to MR imaging.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Quality of Life in a Representative Swedish Population

Study Overview
=================
Brief Summary
-----------------
Cohort descriptive study of quality of life and body functions in a reference population of Swedish inhabitants from age 30 to age 89. The population was selected to be representative for the general Swedish population and 500 in each 10 year group, 250 men and 250 women. The population is contacted and asked for informed consent, whereafter a questionnaire of about 200 questions, used in a number of studies in clinical studies and trials, are sent out. The results will be used as reference values to our patient cohorts

Detailed Description
-----------------
Individuals contacted by letter with information about the study and it's aim. The next step is a telephone contact from the study secretariate where the person can ask for more detailed information and put questions to the reserach nurse. The call leads up to a question to the person, if the questionnaire can be sent. If yes, the questionnaire is posted includeing the consent form and an pre-paid return envelope. After two weeks a thank you/reminder letter is sent out, and if no reply one more phone call is made two weeks further on.

Official Title
-----------------
Quality of Life and Body Functions in a Representative Swedish Population

Conditions
-----------------
Quality of Life

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: list generated by the equivalent to inland revenue (Skatteverket, Sweden) Exclusion Criteria: unable to read and understand Swedish no informed consent

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 89 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| quality of life | answers to specific questions in questionnaire The time frame of most questions is How would you rate your quality fo life during the last month | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| sexual health | answers to various questions in questionnaire | 12 months | 
| gastrointestinal function | answers to various questions in questionnaire | 12 months | 
| urinary function | answers to various questions in questionnaire | 12 months | 
| other body functions | answers to various questions in questionnaire | 12 months | 
| mental health | answers to various questions in questionnaire | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
health related quality of life
Comparison of Apnea Tolerance in Two Positions of Patients With BMI 30-40

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to compare the effect of the 25° head-up position versus the 55° head-up position on tolerable apnea time (TAT) after induction of general anesthesia in patients with a body mass index (BMI) of 30-40.

Official Title
-----------------
Comparison of Apnea Tolerance in Two Positions of Patients With Body Mass Index (BMI) 30-40

Conditions
-----------------
General Surgery

Intervention / Treatment
-----------------
* Other: 25° head-up position
* Other: 55° head-up position


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: American Society of Anesthesiologists (ASA) physical status I-III Body Mass Index (BMI) of 30-40 Scheduled for an elective surgery that requires tracheal intubation Exclusion Criteria: Patients with abnormalities of the upper airway that require awake tracheal intubation Asthma Chronic obstructive pulmonary disease Congestive heart failure Pregnant patients

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: A - 25° head-up position<br>Participants will be positioned at 25° angle for procedure. | Other: 25° head-up position<br>* Participant will be positioned at 25° angle for procedure.<br>|
| Active Comparator: B - 55° head-up position<br>Participants will be positioned at 55° angle for procedure. | Other: 55° head-up position<br>* Participant will be positioned at 55° angle for procedure.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tolerable Apnea Time (TAT) | Measure of the TAT between groups to determine if the TAT is a function of the participant's position. | Time between start of induction of general anesthesia (SpO2 100%) to decline of SpO2 94%, up to eight minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of time to intubation (TTI) |  | Time between start of the tracheal intubation procedure to completion of tracheal intubation, up to 2 minutes | 
| Peripheral arterial hemoglobin oxygen saturation (SpO2) trough | Measure of the rebound SpO2. It is the lowest SpO2 reading reached subsequent to start of mechanical ventilation at the SpO2 value of 94% and it represents final completion of SpO2 decline. | Time until SpO2 decreased to 92%, up to 8 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
tracheal intubation
Human Neck Brown Adipose Tissue mRNA Profile, a Seasonal Variation Study.

Study Overview
=================
Brief Summary
-----------------
The primary objective in this study is to examine the seasonal variation in genetic markers in the deep neck adipose tissue in humans. Human adipose tissue biopsies are taken from patients admitted for elective surgery in the neck. During the surgical procedure a subcutaneous adipose tissue biopsy is taken for reference.

Detailed Description
-----------------
The knowledge of brown adipose tissue (BAT) is derived mainly from studies in rodents where cold is an important regulator of BAT development and function. Yet, little is known about the regulation of BAT in humans. With this study the investigators aim to investigate the effects of seasonal changes in outdoor temperature on genetic markers of BAT in human deep neck adipose tissue. Project participants are patients who are admitted to Aarhus University Hospital for elective neck surgery. Operations are primarily due to suspected malignancy in the thyroid gland or hyperparathyroidism.No additional surgery is necessary to obtain the biopsies.

Official Title
-----------------
Human Neck Brown Adipose Tissue mRNA Profile, a Seasonal Variation Study.

Conditions
-----------------
Nonshivering Thermogenisis

Intervention / Treatment
-----------------
* Other: Outdoor weather


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: written concent Exclusion Criteria: -
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Summer<br> | Other: Outdoor weather<br>* Seasonal changes in temperature<br>|
| Winter<br> | Other: Outdoor weather<br>* Seasonal changes in temperature<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differences in gene expression in BAT associated genes (PGC1a, UCP1, CIDEA, PRDM16) | biopsies will be grouped depending on outdoor temperature, differences in subcutaneous- and deep neck values, | 1 day (The biopsies will be taken as a point in time value. Differences between seasons will be assesed. And so will correlations between genes at one point in time.) |