linjc16/ctgov huggingface dataset:
Relationship Between CMR-derived Parameters of Ischemia / Reperfusion Injury and Timing of CMR in STEMI

Study Overview
=================
Brief Summary
-----------------
This a prospective observational study including patients with ST-segment elevation myocardial infarction undergoing cardiovascular magnetic resonance for clinical reason during the index hospitalization. This local registry stemmed from multi-center european registry on cardiovascular magnetic resonance

Official Title
-----------------
Relationship Between CMR-derived Parameters of Ischemia / Reperfusion Injury and the Timing of CMR After Reperfused ST-segment Elevation Myocardial Infarction

Conditions
-----------------
Myocardial Infarction

Intervention / Treatment
-----------------
* Other: No intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of STEMI Undergoing CMR during the index hospitalization Exclusion Criteria: Refractory cardiogenic shock claustrophobia eGFR<30 ml/min/1.73m2

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No intervention<br> | Other: No intervention<br>* No intervention<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Metrics of ischemia / repercussion injury |  | June 2017 |
Safety and Efficiency of Photodynamic Therapy for Rectal Cancer

Study Overview
=================
Brief Summary
-----------------
This research is a prospective randomized controlled trial.It aimed to determine longterm outcomes and factors associated with increased survival after photodynamic therapy (PDT) through colonscopy compared with chemotherapy alone in patients presenting with advanced rectal cancer.

Official Title
-----------------
Longterm Outcome of Photodynamic Therapy Compared With Chemotherapy Alone in Patients With Advanced Rectal Cancer

Conditions
-----------------
Advanced Rectal Cancer

Intervention / Treatment
-----------------
* Procedure: Photodynamic therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1.Patients with advanced rectal cancer 2.Patients are willing to join in this clinical trial. Exclusion Criteria: 1.Patients with advanced rectal cancer can not suffer PDT procedure. 2.Allergy to photosensitizer

Ages Eligible for Study
-----------------
Minimum Age: 25 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Chemotherapy alone<br>Group that be scheduled to undergo chemothrapy only using FOLFOX4 protocol. | |
| Experimental: PDT and Chemotherapy<br>Group that not only be scheduled to undergo chemothrapy using FOLFOX4 protocol,but also receive colonscopy-assisted PDT. | Procedure: Photodynamic therapy<br>* Each patient to whom PDT was offered underwent a specific, detailed educational process by a dedicated team member(P.B., P.J., or K.E.), after which informed consent was obtained.Porfimer sodium (Photofrin; Axcan Pharma Inc, Quebec, Canada)was used as a photo sensitizing agent, administered intravenously at a dose of 2 mg/kg body weight 48 hours before illumination.A diode laser system (InGaAIP Laser Diode; Diomed Inc, An-dover, MA) with a maximum power output of 2000 mW and a wavelength of 633+-3 nm was used as a light source, delivered through a 3.0-m length fiber having a 2.5-cm-long cylindrical diffuser at its distal end (Pioneer Optics, Windsor Locks, CT).<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Survival rate |  | one month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression-free survival |  | One month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
rectal cancer, rectal adenocarcinoma, photodynamic therapy, chemothrapy
ELRIAH Score: A Simple Score for HCC Risk Stratification in CHC Patients With Cirrhosis or Advanced Liver Fibrosis Who Achieved SVR Following DAA Therapy

Study Overview
=================
Brief Summary
-----------------
aimed to develop a scoring system to assess risk of developing HCC in a large cohort of chronic hepatitis C (CHC) patients with advanced hepatic fibrosis (F3) or cirrhosis (F4) with sustained virological response (SVR) after receiving direct acting antivirals (DAAs).

Detailed Description
-----------------
Current guidelines recommend biannual surveillance for hepatocellular carcinoma (HCC) in all patients with cirrhosis. However, risk of HCC incidence is not the same for different patients. The study aimed to develop a scoring system to assess risk of developing HCC in a large cohort of chronic hepatitis C (CHC) patients with advanced hepatic fibrosis (F3) or cirrhosis (F4) with sustained virological response (SVR) after receiving direct acting antivirals (DAAs).

Official Title
-----------------
ELRIAH Score: A Simple Score for HCC Risk Stratification in CHC Patients With Cirrhosis or Advanced Liver Fibrosis Who Achieved SVR Following DAA Therapy

Conditions
-----------------
HCC

Intervention / Treatment
-----------------
* Drug: DDA


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: no history of previous HCC SVR after DAAs treatment Exclusion Criteria: history of previous HCC

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: DDA|Follow up after SVR|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of HCC incidence after viral clearance |  | 12-45 months after SVR |
Clinical Evaluation of Sectional Matrix Versus Circumferential Matrix for Reproduction of Proximal Contact

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to evaluate the effects of different matricing techniques either sectional matrix or circumferential matrix on reproduction of optimum proximal contacts and contours during restoration of class II cavities with resin composite by undergraduate students or postgraduate dentists.

Official Title
-----------------
Clinical Evaluation of Sectional Matrix Versus Circumferential Matrix for Reproduction of Proximal Contact by Undergraduate Students and Postgraduate Dentists: Randomized Controlled Trial

Conditions
-----------------
Proximal Contact

Intervention / Treatment
-----------------
* Device: MD ring and precontoured sectional matrix by TOR VM
* Device: Circumferential matrix and tofflemire retainer by Kerr


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Compound class II cavities Good oral hygiene No spacing or crowding Healthy peridontium Exclusion Criteria: Complex class II cavities Poor oral hygiene Spacing or crowding Evidence of peridontal disease

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Sectional matrix<br>precontoured sectional matrix band | Device: MD ring and precontoured sectional matrix by TOR VM<br>* MD ring (separation ring) and precontoured sectional matrix (thickness 0.035mm hard) and a wedge was used to secure matrix in place<br>|
| Active Comparator: Circumferential matrix<br>Circumferential matrix band applied by tofflemire retainer | Device: Circumferential matrix and tofflemire retainer by Kerr<br>* Circumferential matrix (thickness 0.038mm) applied by tofflemire retainer and secured in place with wedge<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proximal contact | Reproduction of proximal contact either optimum, tight or loose (Categorical) | Up to 3 hours from randomization till contact is restored |
New Tools for the Diagnosis, Prognosis and Treatment Follow-up in Chagas Disease

Study Overview
=================
Brief Summary
-----------------
Chagas disease is endemic to Latin America, and is of emerging importance in non-endemic countries because migration of people infected with T. cruzi. Current methods for diagnosis of T. cruzi infection are not ideal. Existing drugs for treatment are very limited, produce severe side-effects, and their effectiveness cannot be properly evaluated. Reliable biomarkers for prognosis, early diagnosis and effectiveness of treatment will be investigated.

Official Title
-----------------
Evolution of Serologic Biomarkers and Diastolic Function and Segmentary Contractility Determined by Echocardiography After Treatment in Chagas Diseases

Conditions
-----------------
Chagas Disease

Intervention / Treatment
-----------------
* Drug: Benznidazole


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients from endemic areas (Latin America) Older than 18 years old and younger than 50 With serological confirmation of Chagas Disease infection with two different techniques Indeterminate or initial cardiac form No previously treated for Chagas Disease Exclusion Criteria: Co-morbidity: previous cardiac disease from other aetiology (ischemic, alcoholic or hypertensive), active inflammatory or immunology diseases for another agent. Hepatic disfunction Pregnancy or lactation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Chagas Disease<br>Participants with no Chagas Disease will be evaluated as a Control Group | |
| Chagas Disease<br>Participants diagnosed with Chagas Disease will be followed-up as a Case Group | Drug: Benznidazole<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Biomarkers for prognosis, early diagnosis and effectiveness of treatment. | Conventional polymerase chain reaction of T. cruzi in blood Measurement of Brain natriuretic factor Measurement of Prothrombotic factors Measurement of antibodies against specific proteins of the trypomastigote of T. cruzi Investigation of the phylogenetics of the parasite and the role of the lineages of T.cruzi in the clinical presentation and disease's progression | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiac function after antiparasitic treatment | - Correlation between biomarkers and alterations of the left ventricle diastolic function and segmentary contractility after antiparasitic treatment | 2 years |
Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment.

Study Overview
=================
Brief Summary
-----------------
It is just an observation study. The investigates want to explore the signal changes of resting state functional Magnetic resonance Imaging (fMRI) after light treatment in jaundice infants. Signal changes contain blood oxygenation level dependent (BOLD) and arterial spin labeling (ASL).Indicator of BOLD is amplitude of low-frequency fluctuation（ALFF).Indicator of ASL is cerebral blood flow (CBF). The investigates assume that the children with jaundice after light therapy, ALFF and CBF will change. Focus on the globus pallidus and subthalamic nuclei. The two brain regions were proved to be abnormal in MRI T1, T2 structure signal in kernicterus. Doctors observe the status of infants aside.Using monitoring probe can see clearly.

Detailed Description
-----------------
resting state fMRI scan light therapy the second time resting state fMRI scan

Official Title
-----------------
Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment.

Conditions
-----------------
Jaundice

Intervention / Treatment
-----------------
* Device: light treatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: hyperbilirubinemia Exclusion Criteria: asphyxia cerebral dysgenesis

Ages Eligible for Study
-----------------
Minimum Age: 1 Day
Maximum Age: 28 Days

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| light treatment<br>clinical routine treatment according to the doctor's advice | Device: light treatment<br>* clinical routine treatment according to the doctor's advice<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| amplitude of low-frequency fluctuation change before and after light treatment | It is indicator of blood oxygenation level dependent. | before and after light treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cerebral blood flow change before after light treatment | It is indicator of arterial spin labeling. | before and after light treatment |
Strength and Strength-ratio of Hip Rotator Muscles at Soccer Players

Study Overview
=================
Brief Summary
-----------------
At this investigation we want to find out whether there is a difference in muscle strength of the internal and external rotation hip muscles between soccer players and non-soccer players caused by typical movement patterns seen in soccer sport.

Detailed Description
-----------------
Nontraumatic hip injuries are a problem often seen in Soccer Players. A biomechanical formation mechanism is probably. Little research has focused on the measurement of hip external and internal rotation strength at soccer players. The purpose of this study is to investigate the influence of soccer sports at the isometric force and force ratio of the hip rotator muscle system. Two samples of Athletes will be compared: Soccer Players (N15) and Non-soccer players (N15) matched in sex, age and level of physical activity to investigate hip rotator force in 3 different angles of hip flexion (0°/45°/90°). The measurement will be made with a handheld dynamometer.

Official Title
-----------------
Strength and Strength-ratio of Hip Rotator Muscles at Soccer Players Compared to Non-soccer Players

Conditions
-----------------
Hip Injuries, Muscular Atrophy, Dysfunction

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Study group: Amateur footballers (N15) in the age between 18 and 35 At least five years of active footballer's career Football training twice weekly Active participation in play No pain or limitations in the area of the hip or the lower extremity Control group: Athletes (N15), non-soccer players with now asymmetric leg activities In the age between 18 and 35 At least twice weekly sports activity for at least 30 minutes No pain or limitations in the area of the hip or the lower extremity Exclusion criteria: Professions with asymmetric leg activities Pain or limitations in the area of the hip or the lower extremity Surgery on the hip in the prehistory

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| hip rotators muscle strength<br> | |
| control group<br>no intervention | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Strength of the internal and external rotators of the hip |  | up to 10 months |
Evaluation of Postural Effects on Multiple-breath-washout Derived Lung Function Parameters

Study Overview
=================
Brief Summary
-----------------
The investigators aim to evaluated the effect of postural changes on novel lung function parameters derived from multiple-breath-washout.

Official Title
-----------------
Evaluation of Postural Effects on Multiple-breath-washout Derived Lung Function Parameters

Conditions
-----------------
Pulmonary Healthy Controls, Pulmonary Disease

Intervention / Treatment
-----------------
* Device: multiple breath washout test (MBW)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with and without known pulmonary disease Exclusion Criteria: pregnancy inability to participate

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| pulmonary healthy controls<br>patients without known pulmonary disease | Device: multiple breath washout test (MBW)<br>* measured in upright and supine position<br>|
| pulmonary disease<br>patients with known or suspected pulmonary disease | Device: multiple breath washout test (MBW)<br>* measured in upright and supine position<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change of lung clearance index (LCI) as determined by multiple breath washout |  | 60 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| repeatability of lung clearance index (LCI) |  | 60 minutes |
A Study to Tailor Advance Directives

Study Overview
=================
Brief Summary
-----------------
In this study, hospitalized patients will first be surveyed regarding their interest in a traditional advanced directive (AD) and then in a modified AD.

Detailed Description
-----------------
The purpose of this study is to assess whether patients will execute an advance directive which offers a limited trial of life-sustaining therapy in non-terminal illness, declines life-sustaining therapy or artificial nutrition in advanced dementia, or declines life-sustaining therapy in general. Advance directives (ADs) as currently drafted have been questioned since they have not had much effect on end-of-life care. However, the reason for the lack of success may be simply that they rarely apply. Traditional ADs, which are limited to terminal illness or persistent vegetative states, are difficult to apply to the more common cases of critical illness in the setting of potentially reversible disease and advanced dementia, which are often not recognized as terminal. In addition, terminal ADs are drafted too narrowly for patients who do not wish for life-sustaining therapy regardless of condition. Patients may execute either AD at the conclusion of the survey. This research has the potential to demonstrate widely reproducible methods on which more precise advance planning can be based and thereby improve end-of-life care.

Official Title
-----------------
A Study to Tailor Advance Directives

Conditions
-----------------
Dementia, Persistent Vegetative State, Terminally Ill

Intervention / Treatment
-----------------
* Behavioral: Advance Directive Selection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Hospitalized patients admitted to the general medical service at the University of Chicago Previously enrolled in a study of hospitalized general medicine patients at the University of Chicago Exclusion Criteria: Patients who score less than 17 out of 30 on the Folstein Mini-Mental Status Examination or who have a proxy decision-maker Patients who are medically unstable based on two or more abnormal vital signs Patients who face a possible new diagnosis of cancer

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Advance Directive Selection|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Advance Directive, Living Will, Terminal Illness