Endophenotype Characterization of a Family Psychiatric Disorder

Study Overview
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Brief Summary
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Bipolar disorder is a chronic and frequent mood pathology, that impacts on emotional and socio-professional life of sick subjects, and also increase mortality by suicide. Suicide is considered as a bipolar disorder result. The main goal of this study is the endophenotype characterization from a clinical and cognitive point of view, of a bipolar spectrum's disorder present in a family, and then highlight a mutation of one of the genes involved is this disorder.

Detailed Description
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Heritability of bipolar disorder is now well established, but seems to be multifactorial in most of the cases. The use of an endophenotype characterized in a family presenting numerous bipolar sufferers enable to reflect the expression of simpler genetic variants than those involved in the disease, and might enable the identification of genes involved in the etiopathogenesis of this endophenotype.

Official Title
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Endophenotype Characterization of a Family Psychiatric Disorder of the Bipolar Spectrum, With an Autosomal Dominant Expression

Conditions
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Healthy Volunteer

Intervention / Treatment
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* Genetic: Endophenotype and sequencing


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Members of a family adult (more than 18 years) Signed informed consents Registered to a French social security or possesor of the European Health Insurance Card Exclusion Criteria: Clinical part : Refusal to sign the participation study consent. Organic affection likely to affect cognitive abilities and brain structures or acute decompensation of a bipolar disorder. Genetic part : Refusal to sign the genetic sample consent.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Healthy volunteers<br>Members of a family | Genetic: Endophenotype and sequencing<br>* Draw an endophenotype and genetic study<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neuropsychological evaluations tests | Neuropsychological evaluations (about one hour) : TMT (Trail Making Test) A and B, Stroop VFT (Visual Field Testing), DST (Dyslexia Screening Test) Tower of London test Hayling, CPT (continuous performance task) CVLT (California Verbal Learning Test) tests. | One day | 
| Eye tracking. | The volunteer will follow an instruction according to the color seen on a screen. This instruction is to look at the side where there is a flashlight and to look at the opopsite if the light is unbroken. Mistakes will be count. | One hour | 
| Blood sampling | Genetic sample for extraction of DNA. | 3 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Bipolar disorder, Endophenotype, Family, Autosomal dominant expression, Sequencing, Heritability