Psychosocial Risk Factors in Stroke and Myocardial Infarction

Study Overview
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Brief Summary
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The aim of this study is to identify groups of subjects at risk of recurrence in secondary prevention based on Psychosocial Factors. The aim is also to propose novel levers to reduce health inequalities in this population so as to develop new prevention strategies for neuro- and cardio-vascular health This study is based on data from questionnaires (Quality of life at work, perceived stress, perceived disease severity) and on behavior indicators (factors related to lifestyle: alcohol, smoking, obesity, sedentarity). Biomarkers of endothelial function (ADMA) will also be assayed. It's an interventional study because of blood sample

Official Title
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INEqualities in Health Psychosocial Determinants of Neuro and Cardio-V@scuLar Disease: Identification of Novel Levers for Secondary Prevention

Conditions
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Myocardial Infarction, Stroke

Intervention / Treatment
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* Biological: blood sample
* Behavioral: questionnaires for psychosocial factors


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who have provided oral consent to participate Patients over 18 years Patients hospitalized for type 1 MI or ischemic stroke/TIA < 24H after symptom onset Age < 65 years With a professional activity (INSEE definition) at the time of the neuro or cardiovascular event At least one of the following risk factors: current smoking, obesity (waist circumference > 88 cm (W)/102 cm (M) or a waist/hip ratio 0.85(W)/0.9(M), sedentarity (physical activity < 150 min / week), alcohol consumption (> 3 standard glasses per day for men, > 2 standard glasses/d for women) Exclusion Criteria: Adult under guardianship Patients without national health insurance cover Pregnant or breast-feeding women Clinical state making it impossible to use questionnaires or to measure risk factors Stroke or TIA not related to atheroma or cardioembolism (dissection, hemopathy…) type > 1 MI

Ages Eligible for Study
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Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: patients with myocardial infarction<br> | Biological: blood sample<br> <br> Behavioral: questionnaires for psychosocial factors<br> <br> |
| Experimental: patients with stroke<br> | Biological: blood sample<br> <br> Behavioral: questionnaires for psychosocial factors<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of psychosocial factors (PSF) on the level of risk for neuro-cardiovascular disease. |  | through the completion study an average of 6 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| study the proportion of diméthyl-arginine asymetrical (ADMA) in patients with PSF |  | 1st day |