Femoral Cartilage Thickness in Knee Osteoarthritis

Study Overview
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Brief Summary
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The aim of the study to investigate the relationship between femoral cartilage thickness in Ultrasonographic evaluation and inflammatory parameters, pain severity and functionality in participants with Knee Osteoarthritis

Detailed Description
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Aim: The aim of the study is to investigate the relationship between femoral cartilage thickness and inflammatory parameters, pain severity and functionality in participants with Knee Osteoarthritis. Methods: This study is designed as a prospective, cross-sectional trial. 90 participants aged between 50-65 years with knee osteoarthritis(OA) and at least 50 participants without any symptom for knee OA are included in the study in accordance with the inclusion criteria. Participants' demographic characteristics will be evaluated, and ultrasonographic measurement will be performed for measuring femoral cartilage thickness. Visual Analog scale will be used for pain severity and Western Ontario and McMaster Universities Osteoartrit index (WOMAC) will be used for assessing functionality of the patients. Also hematologic parameters(neutrophils, leucocytes, lymphocytes, platelet, CRP, erythrocyte sedimentation rate) will be evaluated for investigating the inflammation. The relationship between femoral cartilage thickness and inflammatory parameters, pain severity and functionality in knee osteoarthritis will be analysed for both group.

Official Title
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Investigation of the Relationship Between Femoral Cartilage Thickness and Inflammatory Parameters, Pain Severity and Functionality in Knee Osteoarthiritis

Conditions
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Knee Osteoarthritis

Intervention / Treatment
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* Diagnostic Test: ultrasonographic measurement for femoral cartilage thickness VAS for pain severity WOMAC for functionality


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: diagnosed as knee osteoarthritis aged between 50-65 years volunteer to participate in the study Exclusion Criteria: limitation of cooperation moderate to severe dementia or mental retardation, which may cause limitations in examination, testing and treatment refusal to participate in the study pprevious total knee prosthesis surgery secondary osteoarthritis

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| knee osteoarthritis<br>ultrasonographic measurement for femoral cartilage thickness VAS for pain severity WOMAC for functionality | Diagnostic Test: ultrasonographic measurement for femoral cartilage thickness VAS for pain severity WOMAC for functionality<br>* ultrasonographic measurement for femoral cartilage thickness VAS for pain severity WOMAC for functionality<br>|
| healthy control<br>ultrasonographic measurement for femoral cartilage thickness VAS for pain severity WOMAC for functionality | Diagnostic Test: ultrasonographic measurement for femoral cartilage thickness VAS for pain severity WOMAC for functionality<br>* ultrasonographic measurement for femoral cartilage thickness VAS for pain severity WOMAC for functionality<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ultrasonography | measurement of femoral cartilage thickness | 1 day | 
| Visual Analog Scale | evaluation of pain severity | 1 day | 
| Western Ontario and McMaster Universities Osteoarthritis Index | evaluation of functionality | 1 day | 
| neutrophil account | neutrophil account | 1 day | 
| lymphocyte account | lymphocyte account | 1 day | 
| monocyte account | monocyte account | 1 day | 
| platelet account | platelet account | 1 day | 
| eritrocyte sedimentation rate | eritrocyte sedimentation rate | 1 day | 
| C-reactive protein | C-reactive protein | 1 day |