linjc16/ctgov huggingface dataset:
Nasopharyngeal 24 Hour pH Monitoring in Health Adult Volunteers

Study Overview
=================
Brief Summary
-----------------
Involves a 24-hour pH probe study using the Dx-pH Measurement System on patients who do not have symptoms of laryngopharyngeal reflux or gastroesophageal reflux disease to establish normal values for the Dx-pH Measurement System.

Detailed Description
-----------------
The specific aim of this study is to establish the normal range of values in an adult population with no symptoms of laryngopharyngeal reflux disease or gastroesophageal reflux disease using the Dx-pH Measurement System.

Official Title
-----------------
Nasopharyngeal 24 Hour pH Monitoring in Health Adult Volunteers

Conditions
-----------------
Gastroesophageal Reflux Disease

Intervention / Treatment
-----------------
* Device: Dx-pH Measurement Probe


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years of age or older no symptoms of laryngopharyngeal reflux or gastroesophageal reflux disease score less than 10 on Reflux Symptom Index Exclusion Criteria: age less than 18 known lidocaine allergy history of heartburn, regurgitation, chronic cough, voice changes, globus pharyngeus, excessive throat clearing, or swallowing problems score 10 or greater on Reflux Symptom Index current or past antacid use or other antireflux therapy history of antireflux surgery pregnancy current anticoagulation therapy (warfarin, heparin, aspirin, clopidogrel bisulfate) special/vulnerable populations (children, mentally handicapped, pregnant women, fetuses, prisoners, cognitive impairment, life-threatening disease, social or economic disadvantage)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Dx-pH Measurement Probe|Dx-pH Measurement Probe measures gaseous pH values in the nasopharynx and oropharynx over a period of 24 hours.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To develop a range of normal values in adults without symptoms of laryngopharyngeal reflux. |  | At completion of study | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
GERD, laryngopharyngeal reflux disease
Decrease Implantation Site INFECTION : a Randomized Controlled Trial

Study Overview
=================
Brief Summary
-----------------
Cardiovascular implantable electronic device (CIED) infections have been increasing out of proportion to the number of devices implanted the investigators investigated recent trends and possible causes of the increasing numbers of Cardiovascular implantable electronic device infections.

Detailed Description
-----------------
There are many studies on the preventive use of Antibiotics or povidone iodine to Cardiovascular implantable electronic device (CIED) infections. But, studies of posterior pocket capsule removal is still limited. The investigators had planned research on effects of posterior pocket capsule removal before cardiac devices replacement.

Official Title
-----------------
Phase 1 Study of Prevention of Cardiac Device Replacement Site Infection

Conditions
-----------------
Infection

Intervention / Treatment
-----------------
* Procedure: device replacement(pocket capsule removal)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: scheduled for cardiac devices replacement Exclusion Criteria: under the age of 18 take an antibiotic history of infection within 30 days

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: device replacement<br>remove previously inserted cardiac device and posterior pocket capsule. the pocket that will receive the heart mechanism is sterilized with a hydroperoxide soaked gauze | Procedure: device replacement(pocket capsule removal)<br>* remove previously inserted cardiac device and posterior pocket capsule. the pocket that will receive the heart mechanism is sterilized with a hydroperoxide soaked gauze<br>|
| No Intervention: control group<br>remove previously inserted cardiac device and the pocket that will receive the heart mechanism is sterilized with a hydroperoxide soaked gauze | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| freedom of cardiac device-related infection | check the symptoms of infection. If have symptoms of infection : check the fever, heart rate, respiration rate, blood test, EKG | 1 year after precedure | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| freedom of endocarditis | check the symptoms of infection. If have symptoms of infection : check the fever, heart rate, respiration rate, blood test, EKG | 1 year after precedure | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Infection, prevention, cardiac devices
The Evaluation of Optimal Observation Period for Neurological Recovery in Post-arrest Survivors

Study Overview
=================
Brief Summary
-----------------
To explore whether the patient's neurological function recovery period is sufficient after successful emergency resuscitation recommended by the current guidelines

Detailed Description
-----------------
The research team will collect patient data after successful emergency resuscitation after cardiac arrest in the emergency room of National Taiwan University Hospital, and will collect and analyze the relationship between the time for patients to regain consciousness and drug use, hemodynamic changes, and neurological examination results after resuscitation. To explore whether the patient population needs to extend the observation time of neurological function after a certain CPR emergency treatment, and allow the patient to have a longer observation period to regain consciousness.

Official Title
-----------------
The Evaluation of Optimal Observation Period for Neurological Recovery in Post-arrest Survivors

Conditions
-----------------
Cardiology

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with non-traumatic cardiac arrest in the emergency room of National Taiwan University Hospital (including pre-hospital cardiac arrest and in-hospital cardiac arrest) after successful emergency resuscitation Exclusion Criteria: Under 20 years old Pregnant women Those who have not been admitted to the intensive care unit Unconsciousness before the heartbeat stops A clear consciousness after successful first aid resuscitation

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | In-hospital mortality | through study completion, an average of 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cardiac arrest, post-cardiac arrest syndrome, neurological outcome
Temporomandibular Disorders Among Patients With Tinnitus

Study Overview
=================
Brief Summary
-----------------
The incidence of temporomandibular disorders will be studied among patients with tinnitus, by the use of patient's history and physical examination.

Detailed Description
-----------------
The patients with tinnituswill be asked about symptoms related to temporomandibular disorders, and also will be examined in order to diagnose such disorders.

Official Title
-----------------
Incidence of Temporomandibular Disorders Among Patients With Tinnitus

Conditions
-----------------
Tinnitus, Temporomandibular Disorder

Intervention / Treatment
-----------------
* Other: No intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Tinnitus lasting more than 3 months Exclusion Criteria: Head and Neck Space Occupying Lesion Previous degenerative disease of the temporomandibular koint

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with tinnitus<br>Patients (over 18 years old) seen at the medical center due to tinnitus, lasting at least 3 months. | Other: No intervention<br>* No intervention<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Description of temporomandibular disorders in the patient's history | A questioannaire asking specifically about pain in the tempromandibular joint, headaches, clicks, tempromandibular joint locking and dislocation | 1 year | 
| Positive findings in the physical examination of the temporomandibular joint and muscles | The following parameters will be documented: clicks, maximal opening of the mouth, signs of teeth grinding, tenderness on the mastication muscles | 1 year |
Testing Spectrosense EVA System for Detection of Pancreatic Cancer by Analyzing Volatile Organic Compounds (VOCs) in Exhaled Air

Study Overview
=================
Brief Summary
-----------------
Volatile Organic Compounds (VOC) in human breath are captured and analyzed by the Spectrosense EVA system, which is combination of a gas chromatography (GC) and software algorithm. The objective is to obtain a set or sets of VOC bio-markers that will provide the best discrimination between Pancreatic Cancer sick population and healthy population. The gold standard for identifying sick/healthy population is biopsy proven Pancreatic cancer.

Official Title
-----------------
Testing Spectrosense EVA System for Detection of Pancreatic Cancer by Analyzing Volatile Organic Compounds (VOCs) in Exhaled Air

Conditions
-----------------
Pancreatic Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Pancreatic cancer Group Inclusion Criteria: Age from 18 years old Pancreatic cancer positive biopsy Before any treatment Signed Informed Patient Consent Exclusion Criteria: Age under 18 years old Neoadjovant treatment Post surgery for Pancreatic cancer A history of any other cancer type, except skin cancer that is not melanoma Healthy Group Inclusion Criteria: Healthy patients No history of Pancreatic cancer Signed Informed Patient Consent Exclusion Criteria: History of Pancreatic cancer Pancreatic cancer background in the family A history of any other cancer type, except skin cancer that is not melanoma

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pancreatic Cancer<br> | |
| Healthy<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Obtaining a set or sets of VOC bio-markers that will provide the best discrimination between Pancreatic Cancer sick population and healthy population. | An optimization algorithm will select VOCs that will provide maximal sensitivity and specificity. | Baseline |
Olanzapine in the Treatment of Anorexia Nervosa

Study Overview
=================
Brief Summary
-----------------
This study compared 10 weeks of treatment with olanzapine versus placebo in adolescent females with anorexia nervosa-restricting type who were undergoing acute treatment on an inpatient unit or a day hospital program that specializes in the treatment of eating disorders.

Official Title
-----------------
Pilot Study of the Efficacy of Olanzapine in the Treatment of Anorexias Nervosa

Conditions
-----------------
Anorexia Nervosa

Intervention / Treatment
-----------------
* Drug: olanzapine
* Drug: placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Females, ages 12-23 Exclusion Criteria: Binge-purge type

Ages Eligible for Study
-----------------
Minimum Age: 12 Years
Maximum Age: 23 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>olanzapine | Drug: olanzapine<br>* flexibly dosed oral olanzapine 2.5 to 15 mg/day<br>|
| Placebo Comparator: 2<br>matching placebo | Drug: placebo<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| weight gain |  | 10 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| measures of psychiatric symptoms |  | 10 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
anorexia nervosa, treatment, adolescents, olanzapine
Preoperative Preparation for Children

Study Overview
=================
Brief Summary
-----------------
Children scheduled for elective surgery are randomized into a control and intervention group. Children in the intervention group receive a CD and booklet of relaxation and distraction stories to listen to/read during the preoperative period. Preoperative anxiety is assessed by the child life specialist in the preoperative holding area. Ease of induction and emergence from anesthesia are rated by the anesthesia care provider. Post-hospital behaviors are reported by the parents one week after discharge. It is hypothesized that children receiving the intervention will have less anxiety, easier induction and emergence from anesthesia, and fewer changes in post-hospital behaviors than children in the control group.

Official Title
-----------------
Preoperative Preparation for Children: Use of Relaxation and Distraction

Conditions
-----------------
Elective Surgery, Anxiety

Intervention / Treatment
-----------------
* Behavioral: Healing images, relaxation and distraction materials


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children between 4-12 years of age scheduled for elective surgery Exclusion Criteria: Children < 4 years of age or > 12 years of age

Ages Eligible for Study
-----------------
Minimum Age: 4 Years
Maximum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Healing images, relaxation and distraction materials|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| do children who receive the intervention have less anxiety, easier induction and emergence from anesthesia |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| do children who receive the intervention have fewer changes in post-hospital behaviors |  |  |
Evaluation of the Timing of the Nebulization Related to the Physiotherapy Session

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine the optimal time for the nebulization depending on the respiratory physiotherapy session in cystic fibrosis patients.

Conditions
-----------------
Cystic Fibrosis

Intervention / Treatment
-----------------
* Procedure: Airway clearance technique
* Drug: Amikacin nebulization


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Stable cystic fibrosis patients older than 16 y.o. Pseudomonas aeruginosa colonization Hypersecretion Exclusion Criteria: Kidney failure No pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 16 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Nebulization and airway clearance technique<br>nebulization combined to airway clearance | Procedure: Airway clearance technique<br> <br> Drug: Amikacin nebulization<br> <br> |
| Active Comparator: Nebulization<br>nebulization | Drug: Amikacin nebulization<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Urinary excretion of amikacin | Pharmacokinetic study of the urinary excretion of amikacin after nebulization | 24h after the nebulization | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Amikacin concentration into the sputum |  | At the end of the nebulization, an expected average of 20 minutes |
The Effects of Ethanol on Intestinal Permeability and Gut Hormones

Study Overview
=================
Brief Summary
-----------------
The aime of this study is to envsitigate if ethanol has an incretin effect. This is done by administration of ethanol orally vs. an isoethanolaemic i.v. infusion of ethanol.

Official Title
-----------------
The Effects of Orally Ethanol vs. Isoethanolaemic i.v. Infusion of Ethanol on Intestinal Permeability and Gut Hormones

Conditions
-----------------
Ethanol, Insulin Resistance, Incretin Effect

Intervention / Treatment
-----------------
* Other: Ethanol


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Caucasian male between 20 and 50 years of age Body mass index (BMI) between 19 and 25 kg/m2 Weekly alcohol intake of less than 14 units of alcohol (of 12 g) Normal fasting plasma glucose concentration (i.e. <6 mmol/l) and normal glycated haemoglobin A1c (HbA1c) (i.e. ≤42 mmol/mol) Normal haemoglobin Informed consent Exclusion Criteria: First-degree relatives with diabetes and/or liver disease Liver disease or other alcohol-related diseases, diabetes mellitus Liver disease (serum ALAT and/or serum ASAT >2 × normal values) Nephropathy (serum creatinine above normal range and/or albuminuria)

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Oral day<br>Participant receive ethanol orally | Other: Ethanol<br>* The intervention is two different administrationforms of ethanol, orally and i.v.<br>|
| Experimental: i.v. infusion day<br>Participant receive ethanol in an i.v. infusion | Other: Ethanol<br>* The intervention is two different administrationforms of ethanol, orally and i.v.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum insulin level | difference in serum insulin level between the two administration forms | 2 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Incretin effect, Ethanol
Identification and Characterization of Novel Proteins and Genes in Head and Neck Cancer

Study Overview
=================
Brief Summary
-----------------
Through this study, we hope to learn more about the mechanisms, which may contribute to development and progression of head and neck cancer. The long-term goal of this study will be to develop new strategies and drugs for the diagnosis and treatment of head and neck cancer.

Official Title
-----------------
Identification and Characterization of Novel Proteins and Genes in Head and Neck Cancer

Conditions
-----------------
Head and Neck Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients undergoing surgery at Stanford University for head and neck cancer. Exclusion Criteria: Non-Stanford patients.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Head and Neck Cancer