linjc16/ctgov huggingface dataset:
Dual Arterial Phase Liver CT in Patients With Suspected Portal Hypertension

Study Overview
=================
Brief Summary
-----------------
Patients with liver cirrhosis is at risk of developing HCC. To diagnose or detect HCC at CT/MRI, optimal late arterial phase (LAP) acquisition is critical to capture the tumor. For LAP acquisition, bolus-tracking is often used at CT. In patients with portal hypertension, however, bolus-tracking occasionally capture early arterial phase which may be related with slow portomesenteric flow. In this study, we obtain dual arterial phase in patients with suspected portal hypertension and determine whether this protocol (dual arterial phase) would provide higher incidence of LAP acquisition than single arterial phase acquisition.

Official Title
-----------------
Multiphasic Liver CT Scan Including Dual Arterial Phase Imaging in Patients With Liver Cirrhosis and Suspected Portal Hypertension: Evaluation of Acquisition of Appropriate Late Arterial Phase Imaging

Conditions
-----------------
HCC, Cirrhosis, Liver

Intervention / Treatment
-----------------
* Diagnostic Test: Liver CT


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Older than 20 years Liver cirrhosis diagnosed with characteristic imaging feature or histology Presence of portal hypertension sign (splenomegaly and varices) Scheduled for liver CT And signed informed consent Exclusion Criteria: Relative or absolute contra-indication of contrast-enhanced CT

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Liver CT with dual arterial phase<br> | Diagnostic Test: Liver CT<br>* Liver CT with precontrast, dual arterial phase, portal venous phase, and delayed phase.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of optimal late arterial phase acquisition | incidences of optimal late arterial phase acquisition in 1st and 2nd acquisition of arterial phase in this protocol (dual arterial phase) CT. | 1 months after study completion | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
CT
Turkish Version of Mini-BESTest, Validity and Reliability for Adult Participants With Sensoriomotor Impairments

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to present the Turkish version of miniBESTest which evaluates the reasons of balance deficit and postural control. Accordingly, a practice of validity and reliability on adult patients with sensoriomotor impairments will be performed by utilizing the Turkish version of miniBESTest in this study.

Detailed Description
-----------------
Physical therapists encounter postural control problems frequently. These problems require multifaceted assessment. Therefore, the treatment of postural control problems should be planned after a multifaceted assessment. Balance Evaluation Systems Test (BESTest) comprises 27 items and evaluate all components of postural control. MiniBESTest is a shortened version of BESTest with 14 tasks. MiniBESTest still addresses almost all components of postural control and can be performed 15 min. MiniBESTest is one of the most common methods which practiced on adult patients. The aim of this study is to present the Turkish version of miniBESTest which evaluates the reasons of balance deficit and postural control. Accordingly, a practice of validity and reliability on adult participants with sensoriomotor impairments will be performed by utilizing the Turkish version of miniBESTest in this study.

Official Title
-----------------
Turkish Version of Mini-BESTest- Balance Evaluation Systems Test: A Translation and Transcultural Adaptation Study Incorporating Validity and Reliability Analysis for Adult Participants With Sensoriomotor Impairments

Conditions
-----------------
Parkinson Disease, Multiple Sclerosis, Trauma, Brain

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical diagnosis of sensoriomotor impairment Able to walk with or without an assistive device (e.g. walker, cane, ankle-foot orthosis...) Ability to tolerate the balance tasks without fatigue. Exclusion Criteria: Severe cognitive or communication impairments Hemodynamic or clinical instability.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mini BESTest | Mini-BESTest focuses on dynamic balance. It includes a total of 14 different tasks, each rated on a 3-level between 0 (severe postural control impairment) and 2 (no postural control impairment) with a maximal score of 28. | 10-15 minutes. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
mini BESTest, balance defisit, postural control, Sensoriomotor impairment
High-Definition 3D Visualization System for Ophthalmic Surgery

Study Overview
=================
Brief Summary
-----------------
To validate a high-definition (HD) three-dimensional (3D) visualization system in cataract surgery

Conditions
-----------------
Cataract

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The patients are scheduled to cataract surgery on both eyes. Exclusion Criteria: The patients who have other complicating ophthalmic diseases or previous history of ophthalmic surgeries were excluded

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| HD 3D<br>The patients received surgeries with HD 3D on their left eyes. | |
| Conventional<br>The patients received surgeries with conventional method on the other eye. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the best corrected visual acuity | operation time, total phacoemulsification time, and postoperative visual outcome | 1 month after the operation | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cataract, HD 3D, Microscope
Peptic Ulcer Perforation Study

Study Overview
=================
Brief Summary
-----------------
The objective of this study is to implement an optimized perioperative course for patients surgically treated for peptic ulcer perforation in order to improve the outcome for these patients. The optimized perioperative course consists of a number of interventions carried out before, during and after surgery.

Official Title
-----------------
Peptic Ulcer Perforation Study - an Optimized Perioperative Course for Patients Surgically Treated for Peptic Ulcer Perforation

Conditions
-----------------
Peptic Ulcer Perforation

Intervention / Treatment
-----------------
* Procedure: An optimized perioperative course


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients surgically treated for benign peptic ulcer perforation Exclusion Criteria: Age < 18 years Pregnant and breastfeeding women Malign ulcer perforation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: An optimized perioperative course|A number of interventions before, during and after surgery|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| All cause mortality rate |  | Within 30 days of surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Perforated peptic ulcer, Mortality
Sleep Application Diary and Sleep Hygiene in Adolescents

Study Overview
=================
Brief Summary
-----------------
The purpose of this study will be to see if adolescents can advance bedtime above what can be accomplished by counseling alone simply by inputting their information into a sleep application diary and reporting this information back to their sleep doctor.

Detailed Description
-----------------
Using a smart phone application, participants will record bedtime and wake up times as well as answer questions about their sleep throughout their participation in this study . Reaction time will also be measured through a smart phone application.

Official Title
-----------------
Does the Utilization of a Sleep Application Diary Improve Sleep Hygiene in Adolescents?

Conditions
-----------------
Dyssomnias

Intervention / Treatment
-----------------
* Behavioral: Sleep Application Diary
* Behavioral: Treatment As Usual


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Males & Females age 12-17 have access to a smart phone (iphone or android) present to a sleep disorder clinic with poor sleep hygiene and seen by a pediatric sleep specialist Exclusion Criteria: significant developmental delays English is not the primary language spoken

Ages Eligible for Study
-----------------
Minimum Age: 12 Years
Maximum Age: 17 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Sleep Application Diary<br>A sleep application diary which will automatically report results back to sleep doctor is used in addition to standard sleep hygiene counseling. | Behavioral: Sleep Application Diary<br>* Tool used to document sleep hygiene.<br>Behavioral: Treatment As Usual<br>* Sleep hygiene counseling<br>|
| Active Comparator: Treatment as Usual<br>Sleep hygiene counseling | Behavioral: Treatment As Usual<br>* Sleep hygiene counseling<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to Bed | improvement in consistency of time to bed | 1 month, 3 months, & 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reaction Time | reaction time measured by reaction time test application | 1 month, 3 months, & 6 months |
Evaluation of the Influence of New Adhesives of Output on Skin

Study Overview
=================
Brief Summary
-----------------
The study investigates the impact real output has on peristomal skin covered by a newly developed adhesive and a standard adhesive

Official Title
-----------------
Evaluation of the Influence of Output on Skin Covered by Newly Developed Adhesives

Conditions
-----------------
Stoma Ileostomy

Intervention / Treatment
-----------------
* Other: Standard adhesive strip
* Other: New adhesive strip


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Have given written informed consent Be at least 18 years of age and have full legal capacity Have had an ileostomy for more than one year Have intact skin on the area used in the evaluation Has an ileostomy with a diameter up to (≤) 35 mm Have a peristomal area accessible for application of patches/adhesive strips (assessed by investigating scientist) Exclusion Criteria: Currently receiving or have within the past 2 month received radio- and/or chemotherapy Currently receiving or have within the past month received topical steroid treatment in the peristomal skin area or systemic steroid (tablet/injection) treatment. Are pregnant or breastfeeding Having dermatological problems in the peristomal- or abdominal area (assessed by investigating scientist) Participating in other interventional clinical investigations or have previously participated in this evaluation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cohort 7<br>This is a sub-study testing the effect of real output applied under two adhesive strips (standard adhesive strip and new adhesive strip) on the skin after 8 hours. | Other: Standard adhesive strip<br>* This is a standard adhesive strip (hydrocolloid) that is part of an ostomy device<br>Other: New adhesive strip<br>* This is a newly developed adhesive strip that in the future might be part of an ostomy device<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Trans epidermal water loss | The condition of the skin (trans epidemeral water loss) is measured after removing the adhesive. | 8 hours |
ATTR Expanded Access Program (EAP) by Ionis

Study Overview
=================
Brief Summary
-----------------
The purpose of this program is to provide expanded access to Inotersen for up to 100 Patients with Hereditary Transthyretin Amyloidosis (hTTR).

Detailed Description
-----------------
The Program is intended to provided expanded access to Inotersen for eligible patients with hATTR who have limited or no available treatment options.

Official Title
-----------------
Expanded Access Program for Inotersen (ISIS 420915) in Patients With Hereditary Transthyretin Amyloidosis (hATTR)

Conditions
-----------------
Amyloidosis, Hereditary

Intervention / Treatment
-----------------
* Drug: Inotersen


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male or female at least 18 years of age with a diagnosis of hATTR Symptoms consistent with polyneuropathy Meet Polyneuropathy Disability (PND) Stage I-III requirements Exclusion Criteria: Known Primary Amyloidosis, Leptomeningeal Amyloidosis or Monoclonal Gammopathy of Undetermined Significance or Multiple Myeloma Have inadequate cardiac function Have low platelet counts Have inadequate renal function

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Inotersen|Inotersen administered by subcutaneous (SC) injections in the abdomen, thigh, or upper arm|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Long-term Treatment on BAY77-1931 (Lanthanum Carbonate) to Measure Lanthanum Concentrations in Bone

Study Overview
=================
Brief Summary
-----------------
To measure lanthanum concentrations in bone in patients with hyperphosphatemia receiving dialysis

Official Title
-----------------
Open Label, Non-controlled Long-term Treatment on BAY77-1931 (Lanthanum Carbonate) to Measure Lanthanum Concentrations in Bone in Patients With Hyperphosphatemia Receiving Dialysis

Conditions
-----------------
Dialysis, Hyperphosphatemia

Intervention / Treatment
-----------------
* Drug: Lanthanum Carbonate (BAY77-1931)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients undergoing dialysis or plan to start dialysis before the initial administration of the study medication Exclusion Criteria: Patients with severe hypocalcemia (adjusted serum calcium level of <7.5 mg/dL)

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Arm 1<br> | Drug: Lanthanum Carbonate (BAY77-1931)<br>* BAY77-1931 750mg, in the morning, day and evening<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in pre-dialysis serum phosphate levels |  | Every 2 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Achievement rate of the target predialysis serum phosphate levels (3.5 mg/dL and 5.5 mg/dL) |  | Every 2 weeks | 
| Changes in corrected serum calcium level |  | Every 2 weeks | 
| Changes in the product of serum calcium and phosphate |  | Every 2 weeks | 
| Changes in serum intact-PHT levels |  | Every 2 weeks | 
| Changes in bone metabolism markers |  | Every 2 weeks |
Short Daily Hemodialysis and Online HDF: Which One is Better?

Study Overview
=================
Brief Summary
-----------------
1. To compare the efficacy of Short Daily Hemodialysis Online HDF in term of adequacy of dialysis.

Detailed Description
-----------------
The investigators intend to compare the efficacy between these modalities of treatment in terms of adequacy and also other parameters such as calcium-phosphorus balance and hematocrit

Official Title
-----------------
Short Daily Hemodialysis and Online HDF: Which One is Better?

Conditions
-----------------
End Stage Renal Disease

Intervention / Treatment
-----------------
* Procedure: Online HDF
* Procedure: Short Daily Hemodialysis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: stable ESRD KT/V > 1.2 for thrice weekly or > 1.8 for twice weekly Exclusion Criteria: Inadequate vascular access flow rate Concurrent medical illnesses History of non-compliance

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Online HDF<br>Online HDF | Procedure: Online HDF<br>* Online HDF<br>|
| Active Comparator: Short Daily Hemodialysis<br>Short Daily Hemodialysis | Procedure: Short Daily Hemodialysis<br>* Short Daily Hemodialysis<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adequacy |  | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hematocrit, calcium, phosphorus |  | 3 months |
Pelvic Floor Symptoms and Quality of Life in Elderly Women - a Population-based Pilot Study

Study Overview
=================
Brief Summary
-----------------
To assess pelvic floor symptoms and quality of life in elderly women.

Detailed Description
-----------------
The aim is to assess pelvic floor symptoms and quality of life in elderly women. The study is conducted as population-based in 100-130 women at the age of 64-66 years. All study objects are examined gynecologically and with vaginal ultrasound. Subjective symptoms are evaluated with validated questionnaires concerning pelvic floor symptoms, sexual symptoms and quality of life. This is a pilot study before a larger scale population-based study.

Official Title
-----------------
Pelvic Floor Symptoms and Quality of Life in Elderly Women - a Population-based Pilot Study

Conditions
-----------------
Urinary Incontinence, Quality of Life

Intervention / Treatment
-----------------
* Other: Gynecological examination


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All women in one municipality aged 64-66 years who are willing to participate in the study. Exclusion Criteria: Persons under guardianship or who does not understand the used questionnaires.

Ages Eligible for Study
-----------------
Minimum Age: 64 Years
Maximum Age: 66 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Gynecological examination|Comparison of questionnaires and gynecological examination|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Validity of questionnaires to find pelvic floor symptoms |  | An average of 4 weeks, from returning the questionnaires to gynecological examination | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of life in elderly women |  | ◦Measures assessed at the time when questionnaires are filled in, one time point | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
pelvic floor, urinary incontinence, quality of life, elderly women