Effect of Potato Fiber on Appetite and Fecal Fat Excretion

Study Overview
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Brief Summary
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Results have indicated that some dietary fibers increase fecal fat excretion and particularly viscous fibers suppress appetite sensation and reduce energy intake. Both these effects may contribute to body weight management. Aim: The aim of the study is to investigate the potential of 3-weeks daily intake of potato pulp (FiberBind), rhamnogalacturonan I isolated potato fiber (RG-I) vs. a low-fiber control (placebo) on satiety and fecal fat excretion in healthy adults. Furthermore, a number of secondary endpoints are investigated.

Official Title
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Effect of Potato Fiber on Appetite and Fecal Fat Excretion

Conditions
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Fecal Fat Increased, Obesity, Appetite

Intervention / Treatment
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* Dietary Supplement: FiberBind
* Dietary Supplement: RG-I fiber
* Dietary Supplement: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy Men BMI between 18.5 and 27.0 kg/m2 Age 20-40 years Exclusion Criteria: Intake of potatoes with main meals more frequent than 4 times per week Chronic diseases (known diabetes, cardiovascular disease, irritable bowels disease, colitis ulcerosa, crohn disease, or other chronic diseases which could affect the results of the present study) Gluten allergy Use of daily prescription medicine (mild analgesics are allowed) Use of lipid-lowering agents (e.g. Becel, HUSK) Use of food supplements of relevance to the study (such as pre- and probiotics) Irregular intake of vitamin /mineral supplements (two weeks prior to and during the entire study period) Smoking Elite athletes (>10 hours of strenuous physical activity per week) Blood donation (<1 month before study commencement and during study period) Participation in other clinical studies (<1 month before study commencement and during study period) Inability (physically or psychologically) to comply with the procedures required by the protocol judged by the Investigator

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: FiberBind<br> | Dietary Supplement: FiberBind<br>* Potato pulp consisting of 68% fiber (5.5 soluble, 76.7% insoluble and 17.8% resistant starch), 9.7% water, 0.3% fat, 7.2% protein and 14% carbohydrates (starch).<br>|
| Experimental: RG-I fiber<br> | Dietary Supplement: RG-I fiber<br>* Soluble fiber extracted from potato pulp consisting of 95% fiber and 5% water.<br>|
| Placebo Comparator: Placebo<br> | Dietary Supplement: Placebo<br>* Low-fiber control<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fecal fat excretion |  | Based on total feces collection the last 3 days of the 21-day intervention periods | 
| Subjective appetite sensations | Assessed by visual analogue scales (VAS) | Assessed on 3-hour meal test on last day of the 21-day intervention periods | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ad libitum energy intake |  | Assessed 3 hours after intake of the test meal on last day of the 21-day intervention periods | 
| Fecal energy excretion |  | Measured based on total feces collection the last 3 days of the 21-day intervention periods | 
| Blood lipids (total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides) |  | Measured before and after the 21-day intervention periods | 
| Insulin and glucose |  | Measured before and after the 21-day intervention periods, and every 30 minutes during the 3-hour meal test on last day of the 21-week intervention periods | 
| Gut permeability marker |  | Measured before and after the 21-day intervention periods | 
| Gastric emptying rate (w. paracetamol) |  | Measured every 30 minutes during the 3-hour meal test on last day of the 21-day intervention periods | 
| Gastrointestinal symptoms (questionnaire) |  | on day 1, 7, 14 and 22 of the 21-day intervention periods | 
| Body weight |  | up to 21-day intervention periods | 
| Blood pressure |  | up to 21-day intervention periods | 
| Breath hydrogen |  | up to 21-day intervention periods | 
| Gut microbiota |  | Measured in a fresh feces sample from day 19-21 of the intervention periods |