Exercise Training as Medicine for Substance Use Disorder Patients

Study Overview
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Brief Summary
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This study compares the effects of high dose and low dose, high intensity, endurance training and strength training in substance use disorder patients. The hypothesis is that the increase in endurance (measured as maximal oxygen uptake) and strength (measured as maximal strength) will be similar in both the high dose and low dose training groups after 24 training sessions over eight weeks. The rationale for this assumption is based on the patient groups poor physical capacity, supporting that a lesser physical workload is needed to achieve a substantial increase in physical capacity. The practical implication could be higher training attendance, because it is likely easier to motivate the patient group when they only have to perform half the workload. It is paramount for this patient group to increase their physical capacity and consequently augment their physical health status since they are in a high-risk group for developing life-threatening lifestyle related diseases.

Official Title
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Effects of Low- Versus High Dose High Intensity Interval Training and Strength Training on Physical Health in Substance Use Disorder Patients: A Randomized Controlled Trial

Conditions
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Substance Use Disorders

Intervention / Treatment
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* Behavioral: High dose training
* Behavioral: low dose training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Being an inpatient at the clinic Free of known cardiovascular disease, pulmonary disease and cancer Exclusion Criteria: Not able to perform a maximal treadmill test Not able to perform a maximal strength test in hack squat

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: low dose training<br> | Behavioral: low dose training<br>* 1 x 4 minutes of high intensity workload on treadmill and 2 repetitions x 4 sets of high intensity workload in hack squat<br>|
| Active Comparator: high dose training<br> | Behavioral: High dose training<br>* 4 x 4 minutes of high intensity workload on treadmill and 4 repetitions x 4 sets of high intensity workload in hack squat<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in oxygen uptake | cardiopulmonary exercise test (CPET) objective gas measurements | baseline to 8 weeks | 
| change in leg muscular strength | One repetition maximum strength test half squat | baseline to 8 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Resistance training, Endurance training