Association Between Stroke and Adrenal Incidentalomas

Study Overview
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Brief Summary
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Adrenal incidentalomas (AIs) are commonly encountered in transsection imaging which purpose not for suspected adrenal disease. However, part of AIs in patients is associated with Stroke. Stroke is a diseases which could cause of disability and death worldwide. In clinical practice, detailed information about the association between stroke and AIs is not available. In this study, the investigators aimed to investigate the risk for disability and death in the large group of stroke patients with AIs.

Detailed Description
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Background: Adrenal incidentalomas (AIs) are commonly encountered in transsection imaging which purpose not for suspected adrenal disease. However, part of AIs in patients is associated with Stroke . The investigators aimed to investigate the risk for disability and death in the large group of stroke patients with AIs. Objective: To measure the association between stroke and levels of autonomous cortisol secretion in patients with AIs. Design: Part 1, Retrospective cohort study. From April 1, 2021, to September 30, 2021, cohort patients with stroke were recruited in this study. The investigators assess the standardised incidence rate of AIs in all patients. Meanwhile, detail information about stroke disease、patient and AIs characteristics were record. Part 2, Prospective cohort study. From Mar 1, 2022, to Feb 29, 2024, cohort patients with stroke plane to recruit in this study. All patient receive the plasma cortisol level after a 1-mg dexamethasone suppression test. The investigators assess the standardised incidence rate of AIs in all patients. Meanwhile, detail information about stroke disease、patient and AIs characteristics would be record.

Official Title
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If Adrenal Incidentalomas Have the Influences to Occur and Progress in Patients With Stroke

Conditions
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Adrenal Incidentaloma, Stroke

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: stroke disease , such as Cerebral infarction、Intracerebral hemorrhage and Subarachnoid hemorrhage. Exclusion Criteria: presence of metastatic cancer; AIs smaller than 1 cm; nonadenoma lesions, such as myelolipomas,hemorrhages, and cysts; oral glucocorticoid treatment with more than single doses in the past 3 months; use of inhaled steroids or medication affecting dexamethasone metabolism; systemic estrogen treatment.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cerebral infarction Group<br>Patients with cerebral infarction, and enrolled in our emergency or clinical department. | |
| Intracerebral hemorrhage Group<br>Patients with intracerebral hemorrhage, and enrolled in our emergency or clinical department. | |
| Subarachnoid hemorrhage Group<br>Patients with subarachnoid hemorrhage, and enrolled in our emergency or clinical department. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence rate of Adrenal incidentalomas | Assess the standardised incidence rate of AIs in all patients with stroke | 5 years | 
| Plasma cortisol level | Plasma cortisol level after a 1-mg dexamethasone suppression test | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diameter of Adrenal incidentalomas | Maximal axial diameter of adrenal incidentalomas by computed tomography scan; Millimetre as a metric unit of length in this study | 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Adrenal Incidentaloma, Autonomous cortisol secretion, Stroke