Beta-alanine and Elder Endurance

Study Overview
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Brief Summary
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The purpose for this study is to determine if beta-alanine supplementation combined with endurance-based resistance training can increase gains in muscular endurance to a greater extent than endurance-based resistance-training alone in older adults.

Official Title
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The Interactive Effects Of Beta-Alanine Supplementation and Resistance Training on Muscular Endurance in Older Adults

Conditions
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Physical Endurance

Intervention / Treatment
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* Dietary Supplement: Beta-alanine
* Dietary Supplement: Placebo
* Behavioral: Muscular endurance exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 60-90 years of age Living independently (not residing in an assisted living facility) Through testing are found not to have sarcopenia Gait speed > 1 m/s Skeletal Muscle Index > 37% in men and > 27.6 % in women Exclusion Criteria Responding with a yes to any question on the PAR-Q. Are currently pregnant, or plan to try and become pregnant during the study Functional impairments that could impede the person's ability to participate in a resistance training program Current or recent use of supplements (within the past 3 months for non-alanine containing supplements or one year for supplements containing beta-alanine). Individuals taking only basic multivitamins (without any herbal co-ingredients) may still be allowed to participate. These situations will be reviewed on a case-by-case basis. Are currently enrolled in a regular exercise program (more than once per week) Current or recent smoker Use of medication containing corticosteroids Mini-mental score of 21 or below Severe musculoskeletal impairment Uncontrolled chronic disease Major depression Severe vestibular problems Exclusion Criteria: Adults unable to consent Individuals who are not yet adults (infants, children, teenagers) Pregnant women Prisoners

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Beta-alanine and muscular endurance exercise<br>Receive 3.2 g/day beta-alanine and 3 days per week of endurance resistance training for 12 weeks | Dietary Supplement: Beta-alanine<br> <br> Behavioral: Muscular endurance exercise<br> <br> |
| Experimental: Beta-alanine without muscular endurance training<br>Receive 3.2 g/day beta-alanine with no endurance resistance training for 12 weeks | Dietary Supplement: Beta-alanine<br> <br> |
| Placebo Comparator: Placebo and muscular endurance exercise<br>Receive similar dextrose placebo and 3 days per week of endurance resistance training for 12 weeks | Dietary Supplement: Placebo<br> <br> Behavioral: Muscular endurance exercise<br> <br> |
| Placebo Comparator: Placebo without muscular endurance training<br>Receive similar dextrose placebo with no endurance resistance training for 12 weeks | Dietary Supplement: Placebo<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Performance of Daily Activities | Short Physical Functional Performance test | baseline, 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Body Fat | Body fat assessment via bioimpedance | baseline, 12 weeks | 
| Change in Muscular Endurance | 20 repetitions to measure decline in muscular power across repetitions | baseline, 12 weeks | 
| Change in Muscular Strength | Maximal weight that could be lifted one time (1RM) | baseline, 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Neuromuscular, Supplementation, Elderly