Skin Adverse Reactions Occuring in Children Treated by Biotherapy for Chronic Inflammatory Disease

Study Overview
=================
Brief Summary
-----------------
Biological treatments (BT) are commonly prescribed to treat chronic inflammatory diseases in children. Paradoxical reactions during treatment with a biological agent can be defined as the appearance or exacerbation of a pathological condition that usually responds to this class of drug while treating a patient for another condition. Limited data are available in children treated by BT on cutaneous paradoxical reactions, or any other cutaneous adverse events occurring during treatment. On the contrary, dermatologists tend to see and manage increasing numbers of cutaneous adverse events, including paradoxical reactions. The aim of this project is to describe the incidence of cutaneous adverse events, including cutaneous paradoxical reactions, occurring in the pediatric population, during a treatment by BT given for a chronic inflammatory disease.

Official Title
-----------------
Cutaneous Adverse Effects Occurring in Children Under Biological Therapy Given for Chronic Inflammatory Diseases

Conditions
-----------------
Biotherapy, Chronic Inflammatory Disease, Allergic Skin Reaction, Pediatric Disorder, Dermatologic Complication, Gastrointestinal Disease, Ophthalmology, Rheumatology

Intervention / Treatment
-----------------
* Other: dermatological consultation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children under 18 years old Children treated by biotherapy among : Adalimumab, Golimumab, Infliximab, Ustekinumab, Etanercept, Tocilizumab, Canakinumab, Anakinra, Abatacept. Children treated for a chronic inflammatory disease (rheumatologic, gastro-enterologic, dermatologic and ophthalmologic) Children treated in the CHU of Amiens Parental consent signed Exclusion Criteria: Age > 18 ans

Ages Eligible for Study
-----------------
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: dermatological consultation|Dermatological consultation will be done on every children treated by biotherapy for chronic inflammatory disease in the Amiens hospital.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Variation of the incidence of cutaneous adverse events under biological therapy | Determine the variation of the incidence of any skin manifestation under biological therapy, including Paradoxical Reaction (psoriasis, eczema, hidradenitis suppurativa …), non-paradoxical inflammatory reaction, infection, neoplasia, hair and nail manifestation, xerosis. | up to 8 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Biotherapy, Chronic Inflammatory Disease, skin adverse event, paradoxical reaction, cutaneous manifestation, pediatry, dermatology, gastro-enterology, ophthalmology, rheumatology