linjc16/ctgov huggingface dataset:
Genetic Study of Obstructive Azoospermia

Study Overview
=================
Brief Summary
-----------------
In 1% of men with infertility, obstructive azoospermia (OA) may occur in congenital absence of the vas (CAVD) or idiopathic obstructive azoospermia . Many studies have shown that the pathogenic genes of OA are CFTR and ADGRG2 genes, and the inheritance mode is autosomal recessive. Although the conventional assisted reproductive technology(PESA/TESA) can help these patients have children, male patients who carry mutations of the disease-causing genes (CFTR and ADGRG2) will also pass on their mutations to the next generation, which will increase the risk of male offspring infertility. Therefore, genetic detection of CFTR and ADGRG2 genes is very necessary for CAVD patients before assisted reproduction. Genetic diagnosis plays a key role in preventing the disease to the offspring.

Official Title
-----------------
Genetic Study of Obstructive Azoospermia

Conditions
-----------------
Genetic Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: (1) No sperm was found after centrifugation for 15min for two or more semen tests, and the interval between two tests was at least 2 weeks. (2) Blood FSH is normal; (3) Hematostatin b is normal; (4) Chromosome karyotype is normal or polymorphic; (5) Y chromosome microdeletion did not show the deletion:(main locus); (6) Biochemical fructose of seminal plasma : less than the normal value; (7) PH of semen <7.2; (8) Transscrotal or transrectal ultrasound: normal testicular size(as measured by B ultrasound), presence or dysplasia of vas deferens and epididymis; Exclusion Criteria: (1) B ultrasound of urinary system suggested abnormal development; (2) Transscrotal or Transrectal ultrasound indicated absence of vas deferens or epididymis or seminal vesicle; (3) Physical examination showed the following abnormalities: cryptorchidism, tenderness of testis and epididymis; (4) The following medical history: genitourinary tract trauma or surgical history; orchitis; epididymitis; Seminal vesicle disease; mumps; (5) Laboratory examination: red and white blood cell elevation of semen routine

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mutation rate | the mutation rate of CFTR and ADGRG2 | through study completion, an average of 3 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
CFTR, ADGRG2, Obstructive azoospermia
Guided Creeping Technique (GCT) in Treating Gingival Recession

Study Overview
=================
Brief Summary
-----------------
A novel minimally invasive guided creeping technique (GCT) is suggested to treat gingival recessions.

Detailed Description
-----------------
Background: Coronally advanced flap with connective tissue grafting in a conventional or minimally invasive approaches includes massive soft tissue reflection that reduce soft tissue support and compromise vascularity around the grafted material. In an attempt to preserve soft tissue support, graft stability and maximizing graft protection in treating recession defects the present novel minimally invasive guided creeping technique (GCT) is suggested. Methods: Twelve patients, each contributing a single Cairo RT1 GR defect, were treated by guided creeping technique and completed the 6 months follow up. Clinical, evaluations were performed and differences among groups were analyzed.

Official Title
-----------------
Guided Creeping Technique (GCT) as a Novel Minimally Invasive Approach in Treating Gingival Recession - Single Arm Preliminary Study

Conditions
-----------------
Gingival Recession

Intervention / Treatment
-----------------
* Procedure: Guided Creeping Technique (GCT)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Over 18 years of age Systemically and periodontally healthy Presence of isolated buccal Cairo RT1 gingival recessions An identifiable CEJ Affected teeth with at least 2mm attached gingiva. Exclusion Criteria: Smokers Pregnancy Using antiepileptic drugs Using antibiotics for at least 20 days before surgery

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Guided Creeping Technique (GCT)<br>Novel minimally invasive guided creeping technique | Procedure: Guided Creeping Technique (GCT)<br>* Guided Creeping Technique (GCT) is a novel minimally invasive blind tunnel<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recession Coverage | Measured in mm | Change from baseline to 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Keratinized Tissue Width | Measured in mm | Change from baseline to 6 months | 
| Keratinized Tissue Thickness | Measured in mm | Change from baseline to 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Minimally Invasive Surgery, Tunneling Techniques, Gingival Recession, Creeping Attachment
Plantar Sensation, Balance, Risk of Falling and Gait in Patients With Schizophrenia

Study Overview
=================
Brief Summary
-----------------
Cerebellar vermis anomalies are present in schizophrenic individuals. This condition leads to postural balance problems. Foot and ankle complex have a special role for maintaining balance. However, there is no study about this topic in schizophrenic individuals.

Official Title
-----------------
Investigation of the Relationship Between Plantar Sensation, Balance, Risk of Falling and Gait in Patients With Schizophrenia

Conditions
-----------------
Plantar Sensation, Balance; Distorted, Fall, Gait Disorders, Neurologic

Intervention / Treatment
-----------------
* Other: Correlation / Observational


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: diagnose of schizophrenia according to DSM-5 being an individual in remission against the risk of having an attack individuals who use the same psychotropic drugs for at least 4 weeks Exclusion Criteria: Individuals with physical and neurological comorbidities

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 64 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Single Group Correlation<br>Correlation between these topics. | Other: Correlation / Observational<br>* correlation between Plantar Sensation, Balance, Risk of Falling and Gait in Patients With Schizophrenia<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Semmes-Weinstein Monofilament test | Plantar sensation | 1 year | 
| Berg Balance Scale | Balance | 1 year | 
| Tinetti Fall Risk Scale | Risk of Falling | 1 year | 
| Spinal Mouse | Spinal flexibility for balance | 1 year | 
| Walk a Line Battery | Gait | 1 year |
Collagenase in the Treatment of Adhesive Capsulitis (Frozen Shoulder)

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to test collagenase injection therapy to dissolve adhesions causing frozen shoulder.

Detailed Description
-----------------
In a random, placebo controlled, double blind study, collagenase injection therapy will be investigated for it's ability to lyse the adhesions associated with the shoulder capsule in adhesive capsulitis (frozen shoulder). Treatment success may obviate the need for extensive physical therapy and/or shoulder arthroscopy (surgery) to correct this condition and restore normal and pain free shoulder motion.

Official Title
-----------------
Collagenase in the Treatment of Adhesive Capsulitis (Frozen Shoulder)

Conditions
-----------------
Adhesive Capsulitis, Frozen Shoulder

Intervention / Treatment
-----------------
* Drug: Collagenase


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: diagnosis of frozen shoulder of at least one month duration Exclusion Criteria: shoulder arthritis rotator cuff tears any chronic, serious, uncontrolled medical condition inability to conform to study visits (20-30 per year)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Collagenase<br>Collagenase Injection | Drug: Collagenase<br>* Anterior shoulder capsule injection<br>* Other names: Xiaflex;|
| Placebo Comparator: Placebo<br>Placebo Injection | Drug: Collagenase<br>* Anterior shoulder capsule injection<br>* Other names: Xiaflex;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Active elevation of the affected shoulder | Active Elevation in degrees by goniometer measurement | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Active and passive shoulder motions in internal/external rotation, passive elevation, pain and function. | Active and passive internal/external rotation in degrees by goniometer measure | 30 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Frozen Shoulder
Learning by Repetitive Viewing of Peer Modeling Patient Education Videos by Adults With Down Syndrome

Study Overview
=================
Brief Summary
-----------------
The learning of appropriate hand washing technique through repetitive watching of a video depicting an adult with DS washing his hands will be studied.

Detailed Description
-----------------
This study is a next step in evaluating the use of videos depicting a person with DS demonstrating hand washing. The initial study demonstrated improvement in hand washing technique with a verbal explanation of hand washing technique using an Illinois Department of Public Health handout and viewing one of the handwashing videos one time. The study demonstrated a statistical significant difference between learning by viewing the handout and a video of an adult with DS washing his hands vs just viewing the handout.viewing a handout Likely due to small sample size, the study did not demonstrate statistical significance between watching the video of a person with DS washing his hands vs watching the other videos but the trend for the best improvement in handwashing technique was for the group viewing another person with DS demonstrating the handwashing. The hypothesis of this study is that repeated viewing of a video and practicing hand washing will lead to even greater improvement in hand washing technique.

Official Title
-----------------
Learning by Repetitive Viewing of Peer Modeling Patient Education Videos by Adults With Down Syndrome

Conditions
-----------------
Trisomy 21, Down Syndrome

Intervention / Treatment
-----------------
* Behavioral: Watching a video


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria Individuals with: DS aged 18 and older The ability to use a checklist or to be taught how to use a checklist The ability to use a tablet or to be taught how to use a tablet Access to an Internet connection Exclusion criteria Individuals who: Are not yet adults Are unwilling to consent and/or assent Are unable or unwilling to return the ADSC for the 1 month and 2 months follow up visits sensitivity to soap

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Repetitive video watching<br>Repetitively watching a video of an adult with Down Syndrome washing his hands | Behavioral: Watching a video<br>* Watching a video of an adult with DS washing his hands<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Appropriate hand washing technique | Measuring appropriate replicating of standard hand washing techniques via standard check list | 2 months |
Validation of the Measurement Accuracy of the Tcore Thermometer

Study Overview
=================
Brief Summary
-----------------
The aim of the study conducted at the UKSH is to investigate the measuring accuracy of the body core temperature thermometer Tcore®. Therefore the bias of the measurements to the reference measurements of the bladder catheter thermometer is determined.

Detailed Description
-----------------
The aim of the study conducted at the UKSH is to investigate the measuring accuracy of the body core temperature thermometer Tcore®. Therefore the bias of the measurements to the reference measurements of the bladder catheter thermometer is determined. Patients included are in the ICU of the UKSH and awake. They already have the reference thermometer in the catheter. The patient investigation time is limited to maximum 2 hours, SAEs will be recorded for 24 hours. The temperature of the two temperature sensors will be compared on three timepoints.

Official Title
-----------------
Validierung Der Messgenauigkeit Des Tcore Thermometers in Der Anwendung Nicht-invasiver Temperaturmessung gegenüber herkömmlicher Invasiver Messung Auf Der Intensivstation Bei Wachen Patienten

Conditions
-----------------
Temperature Change, Body

Intervention / Treatment
-----------------
* Device: Tcore


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Body temperature > 34 °C Signed consent Bladder catheter with temperature sensor Exclusion Criteria: Inflammation of the frontal sinus or the measuring point of the reference measurement (bladder) Skin irritation to the adhesive or other materials used medication that locally affects the body temperature or the temperature of the reference body site (barbiturates, thyroid preparations, antipsychotics, new vaccines, aspirin, acetaminophen, ibuprofen, or similar) Taking antipyretics in the last 120 minutes before measurement

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Tcore|Temperature Measurement of standard care versus the Tcore measurement|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Temperature | Temperature measurements with reference thermometer Tcore® | within 24 hours |
Comparison of Two Different Doses of Bemiparin in COVID-19

Study Overview
=================
Brief Summary
-----------------
Patients requiring hospitalization due to COVID-19 pneumonia (non-severe) will be randomized to standard prophylactic doses or full therapeutic dose of bemiparin (a LMWH) for 10 days.

Official Title
-----------------
Ensayo clínico Aleatorizado, Abierto, Para Evaluar el Efecto de Dosis profilácticas o terapéuticas de Bemiparina en Pacientes Con COVID-19

Conditions
-----------------
COVID-19

Intervention / Treatment
-----------------
* Drug: Bemiparin sodium


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age (equal or more than 18 yo) Hospitalization at conventional wards due to COVID-19 related mild or moderate pneumonia (CURB65<3 points; Sat. O2>90%) 3-4 points according to the WHO ordinal scale. Confirmed COVID-19 (PCR or other validated test) D-dimer >500 ng/mL Sign of informed consent The patient is able, according to investigator's opinion, to deal with all the requirements of the clinical trial. Exclusion Criteria:

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Prophylactic bemiparin (3,500 IU/day)<br>Bemiparin 3,500 IU daily for 10 days | Drug: Bemiparin sodium<br>* Prophilactic vs full-dose for 10 days<br>* Other names: Hibor;|
| Experimental: Full therapeutic bemiparin (weight adjusted)<br>Bemiparin at full therapeutic dose, adjusted to body weight, for 10 days | Drug: Bemiparin sodium<br>* Prophilactic vs full-dose for 10 days<br>* Other names: Hibor;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical deterioration | Combined outcome that includes number of patients who suffer any of the following: Death, ICU admission, mechanical ventilatory support, progression to moderate or severe ARDS (according to Berlin criteria) or arterial or venous thrombosis. | 10 days |
Nutritional Therapy for Diabetic Cardiomyopathy

Study Overview
=================
Brief Summary
-----------------
The goal of this study is to determine if nutritional therapy can effectively treat/prevent T2DM and its consequent cardiomyopathy.

Official Title
-----------------
Nutritional Therapy for Diabetic Cardiomyopathy

Conditions
-----------------
T2DM (Type 2 Diabetes Mellitus)

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subjects must be >30 and <65 years of age, in order to limit the confounding affect of age on our endpoints. Subjects must have an ejection fraction >45% (based on their echocardiogram) Patients with T2DM and nonalcoholic fatty liver disease or steatohepatitis may be included since they have extensive evidence of steatosis. Exclusion Criteria: Subjects who have had a myocardial infarction or resting ischemia (by history or as evidenced by hypo/akinesis on the pre-intervention echocardiogram) will be excluded because hypo/akinesis would affect our endpoints of LV mass and diastolic function. Subjects who are unstable, not able to lie flat for the imaging studies, unable to give informed consent, pregnant, lactating, with atrial fibrillation (which would compromise measurement of E'), or current smokers will be excluded. Subjects with other major systemic diseases per their clinical charts, history, physical exam, or significant renal insufficiency will also be excluded, as these other system diseases may affect our study endpoints and subject follow-up. We will exclude patients with significant LV systolic dysfunction (ejection fraction <45%) We will not exclude patients with sleep apnea because it does not detrimentally affect LV diastolic function. Subjects will be excluded a priori if they have any history or evidence of liver disease other than NAFLD, consumed >20 g alcohol per day.

Ages Eligible for Study
-----------------
Minimum Age: 35 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cardiac function | cardiac function as measured by echocardiography incl. tissue Doppler | 2 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| liver steatosis | liver fat content as measured using MR spectroscopy | 2 weeks | 
| myocardial steatosis | fat in heart muscle as measured using MR spectroscopy | 2 weeks | 
| lipidomics | mass spectroscopy measures of plasma lipid species | 2 weeks |