Combined tDCS and TMS on Subjective Tinnitus and Combined Depression

Study Overview
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Brief Summary
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The investigators combined transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) to increase the effective response of a single session of neuromodulation in subjective tinnitus.

Detailed Description
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To treat motor and psychiatric disorders, transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) are world-widely in use in clinics. The investigators combined these two types of neuromodulation techniques to increase the effective response of a single session of neuromodulation in subjective tinnitus. Experimental groups with 80 tinnitus subjects consisted of four different treatment groups which are tDCS, tDCS with sham TMS, tDCS-TMS and TMS group. Subjects were given 1.5milliampere (mA) tDCS on the bi-frontal area and TMS stimulated contralateral single side of the temporoparietal cortex with 200 pulses at 1herz (Hz) stimulation.

Official Title
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The Effect of Combination Transcranial Direct Current Stimulation and Transcranial Magnetic Stimulation on Subjective Tinnitus and Combined Depression

Conditions
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Tinnitus, Depression

Intervention / Treatment
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* Device: transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Research volunteers who agreed to participate in the clinical trial were gathered from the tinnitus clinic of the Department of Otorhinolaryngology Head-and-Neck Surgery, Seoul National University Bundang Hospital Exclusion Criteria: psychoactive drug user implanted material pacemaker user

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: TMS + tDCS group<br> | Device: transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS)<br> <br> |
| Experimental: sham TMS + tDCS group<br> | Device: transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS)<br> <br> |
| Experimental: tDCS group<br> | Device: transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS)<br> <br> |
| Experimental: TMS group<br> | Device: transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS)<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tinnitus handicap inventory | tinnitus-related questionnaire | the same 1 day after treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Tinnitus, tDCS, TMS