Primary Prevention With Statin and Incidence of Recurrent MI and Cardiogenic Shock in Post-ACS Patients

Study Overview
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Brief Summary
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This study aims to evaluate the effect of statin for primary prevention, towards lowering the incidence of recurrent myocardial infarction, cardiogenic shock and mortality in ACS patients.

Detailed Description
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Adult patients (≥ 18 years of age) with acute coronary syndrome which are diagnosed under ICD-10 coding of I24.9 were included in this study. The inclusion criteria are patients with primary diagnosis of I24.9 and with a complete record of prior medical and treatment history, electrocardiographic findings, cardiac marker results and outcomes. Participants were grouped into 2 groups - statin and non-statin based on prior history of statin use prior to ACS. Diagnosis of ACS was made based on clinical, electrocardiographic and cardiac marker findings found in the medical record. Data such as age, sex, ethnic, education, prior medical and treatment history, electrocardiographic and cardiac enzyme results as well as outcomes were collected from the patients' medical records. Outcomes of interest were defined as either recurrent myocardial infarction, cardiogenic shock, mortality or combinations of them as diagnosed in the medical records. GRACE and TIMI Scores are calculated to predict in hospital and future mortality rates.

Official Title
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Primary Prevention With Statin and Incidence of Recurrent Myocardial Infarction and Cardiogenic Shock in Post-Acute Coronary Syndrome Patients

Conditions
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Acute Coronary Syndrome, Recurrent Myocardial Infarction, Cardiogenic Shock

Intervention / Treatment
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* Drug: Statin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical diagnosis of Acute Coronary Syndrome Presence of detail on statin prescription history Exclusion Criteria: Unavailability of electrocardiographic findings, cardiac marker results, GRACE and TIMI score parameters Incomplete records of prior medical and treatment history
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Statin<br>History of statin use for primary prevention | Drug: Statin<br>* Prescribed with statins for primary prevention<br>|
| Non-Statin<br>No documented history of statin use prior to Acute Coronary Syndrome | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recurrent Myocardial Infarction | Clinical Diagnosis of Recurrent Myocardial Infarction reported in medical records | Through study completion, an average of 1 year | 
| Cardiogenic Shock | Clinical Diagnosis of Cardiogenic Shock reported in medical records | Through study completion, an average of 1 year | 
| Mortality | Patient death reported in medical records | Through study completion, an average of 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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acute coronary syndrome, statin, mortality, GRACE score, TIMI score