Effect of Anesthetic Method on Optic Nerve Sheath Diameter in Patients Undergoing RALP

Study Overview
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Brief Summary
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The purpose of this study was to evaluate the effect of anesthetic method on the optic nerve sheath diameter in patients undergoing robot-assisted laparoscopic prostatectomy.

Detailed Description
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The purpose of this study was to evaluate the difference between the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil-dexmedetomidine and the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil in patients undergoing robot-assisted laparoscopic prostatectomy.

Official Title
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Effect of Anesthetic Method on Optic Nerve Sheath Diameter in Patients Undergoing Robot-assisted Laparoscopic Prostatectomy: Comparison of Sevoflurane-remifentanil and Sevoflurane-remifentanil-dexmedetomidine

Conditions
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Prostate Cancer

Intervention / Treatment
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* Drug: Dexmedetomidine
* Other: Without dexmedetomidine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Undergone a robot-assisted laparoscopic prostatectomy with a prostate - cancer 20 years of age or older and under 80 years of age Agree to participate in this study Exclusion Criteria: History of cerebral hemorrhage or cerebral infarction < 20 years of age ≥ 80 years of age Glaucoma Unexpected hemodynamic instability during surgery Failure to measure optic nerve sheath diameter Convert to open surgery

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 79 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Anesthesia with dexmedetomidine<br>Anesthesia with sevoflurane-remifentanil-dexmedetomidine Dexmedetomidine :Continuous infusion of dexmedetomidine with loading dose of 1.0 μg/kg (0.25 ml/kg) for 10 minutes, then followed by maintenance dose of 0.4 µg/kg/hr (0.1 ml/kg/hr). | Drug: Dexmedetomidine<br>* Anesthesia with sevoflurane-remifentanil-dexmedetomidine<br>* Other names: With Dexmedetomidine;|
| Placebo Comparator: Anesthesia without dexmedetomidine<br>Anesthesia with sevoflurane-remifentanil Normal saline :Continuous infusion of normal saline with loading dose (0.25 ml/kg) for 10 minutes, then followed by maintenance dose (0.1 ml/kg/hr). | Other: Without dexmedetomidine<br>* Anesthesia with sevoflurane-remifentanil<br>* Other names: With normal saline;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in optic nerve sheath diameter | Difference between the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil-dexmedetomidine and the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil in patients undergoing robot-assisted laparoscopic prostatectomy | 60 minutes after pneumoperitoneum and steep Trendelenburg position | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in optic nerve sheath diameter | Difference between the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil-dexmedetomidine and the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil in patients undergoing robot-assisted laparoscopic prostatectomy. | 30 minutes after pneumoperitoneum and steep Trendelenburg position | 
| Difference in optic nerve sheath diameter | Difference between the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil-dexmedetomidine and the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil in patients undergoing robot-assisted laparoscopic prostatectomy | 10 minutes after anesthesia induction | 
| Difference in optic nerve sheath diameter | Difference between the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil-dexmedetomidine and the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil in patients undergoing robot-assisted laparoscopic prostatectomy | At skin closure |