linjc16/ctgov huggingface dataset:
Body Composition, Glucose Metabolism, Insulin Resistance and Gene Expression in Muscle Cells in Healthy Overweight Women

Study Overview
=================
Brief Summary
-----------------
In this study, we will clarify the degree of insulin resistance and characterise muscle glucose metabolism and gene expression in a group of overweight healthy women. The study will clarify how overweight influences body glucose metabolism and thereby in the long-run increases the risk for developing type 2 diabetes. Moreover, the study may clarify why some overweight women develop hormone disorders and diabetes while others remain healthy. The study is essential as many patients suffer from diseases aggravated by overweight. In addition, a genetic disposition for diabetes or polycystic ovary syndrome may give rise to the disease if the patient gains weight. It is therefore important that weight-matched control subjects are included in projects with overweight patients. This clinical trial includes 10 overweight women with regular hormones and normal level of male sex hormone. The patients included must be healthy, take no medications influencing the study results. The subjects must take no contraceptive pills or receive any other hormone treatment. In connection with the investigation, the following will be carried out on all patients: clinical examination, blood tests, hyperinsulinaemic euglycaemic clamp, muscle biopsies, bone scan. The purpose of the study is to gain more knowledge of how overweight influences women's risk of developing hormone diseases and diabetes.

Official Title
-----------------
Body Composition, Glucose Metabolism, Insulin Resistance and Gene Expression in Muscle Cells in Healthy Overweight Women

Conditions
-----------------
Obesity, Type 2 Diabetes, Polycystic Ovary Syndrome

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Regular menses, i.e. cyclus length 25-34 days Premenopausal Ferrimann-Gallway score < 2 BMI > 27 kg/m2 normal total testosterone value < 3.5 nmol/l Exclusion Criteria: Age <18 years Contraceptive pills within the past 3 months Postmenopausal (increased FSH) Diabetes mellitus Endocrine or other disease requiring treatment Eating disorder or other psychiatric history Drug use known to influence parameters investigated in this trial Pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Polycystic ovary syndrome, growth hormone, insulin resistance, overweight, glucose metabolism
Neuroplasticity-oriented Cognitive Intervention in Early Onset and First Admission Schizophrenia

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to reveal the specific effects of computer-aided cognitive training on course and rehabilitation in early onset schizophrenia

Detailed Description
-----------------
Impairment in cognitive functions is one of the main symptoms in schizophrenia and is currently one of the challenges in the treatment of the disease. We examine the beneficial effect of computer-aided training program on course and rehabilitation of young psychotic patients with early onset psychosis. In addition we develop predictors for the course of disorder from neuroimaging data.

Official Title
-----------------
Neuroplasticity-oriented Cognitive Intervention in Early Onset and First Admission Schizophrenia

Conditions
-----------------
Psychosis

Intervention / Treatment
-----------------
* Behavioral: Brain Fitness Training, Posit Science SF


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Early Onset Psychosis Exclusion Criteria: Chronicity Insufficient German skills

Ages Eligible for Study
-----------------
Minimum Age: 17 Years
Maximum Age: 37 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cognitive Training<br>Brain Fitness Training, Posit Science SF | Behavioral: Brain Fitness Training, Posit Science SF<br>* Computer aided cognitive training based on principles of neuroplasticity<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change from baseline at post-training and at 3-months and at 7-months follow-up in each of the following outcome measures: neuropsychological test performance (MCCCB), GAF, PANSS, MEG event-related potentials (M50), alpha activity |  | baseline, post-training (training duration 4 weeks), 3-month follow-up, 7-month follow-up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change from baseline in GAF score at 3-months and 7-moths follow-up |  | baseline, 3-months follow-up, 7-months follow-up | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Brain Oscillations, Cognitive Performance
Risk of Osteoarthritis of the Knee at Least 5 Years After ACL Reconstruction: Comparative Study Between an Isolated ACL Reconstruction and a Reconstruction Combining ACL and ALL

Study Overview
=================
Brief Summary
-----------------
The main objective of this study is to compare, with a minimum follow-up of 5 years, the prevalence of femoro-tibial osteoarthritis after an isolated ACL ligamentoplasty or after an ACL ligamentoplasty combining ACL and ALL.

Official Title
-----------------
Risk of Osteoarthritis of the Knee at Least 5 Years After ACL Reconstruction: Comparative Study Between an Isolated ACL Reconstruction and a Reconstruction Combining ACL and ALL

Conditions
-----------------
ACL, Anterior Curciate Ligament, Anterolateral Ligament, Knee Injuries, ALL

Intervention / Treatment
-----------------
* Procedure: Radiography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients who underwent an isolated Anterior Cruciate Ligament (ACL) reconstruction or a combined ACL and anterolateral ligament reconstruction (Extra Articular Plasty) between January 1, 2011 and March 31, 2012. Patients affiliated or beneficiaries of a social security scheme Patients who have given their express consent. Exclusion Criteria: Patients with pediatric ACL reconstruction technique Patients with a complex associated gesture such as osteotomy or ligamentoplasty other than extra articular plastic surgery. Contraindication to a radio control (pregnancy) Patient's refusal to participate in the study Protected patients: Adults under guardianship, curatorship or other legal protection, deprived of their liberty by judicial or administrative decision; Pregnant, breastfeeding or parturient woman; Hospitalized without consent.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patient operated with isolated ACL knee reconstruction<br> | Procedure: Radiography<br>* Comparative X-ray of the single knee at 30 ° flexion.<br>|
| Experimental: Patient operated with ACL and ALL knee reconstruction<br> | Procedure: Radiography<br>* Comparative X-ray of the single knee at 30 ° flexion.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assessment of the prevalence of femoro-tibial osteoarthritis | The prevalence of femoro-tibial osteoarthritis will be assessed by the percentage of patients with cartilage damage to the femoro-tibial compartments on a single X-ray of the face compared to 30 °of flexion. | 1 day |
The Value of Diffusion-weighted Imaging in Evaluating the Early Efficacy of Liver Metastasis in Colorectal Cancer

Study Overview
=================
Brief Summary
-----------------
The study is designed to evaluate the value of DWI-MRI (Diffusion weighted magnetic resonance imaging) in predicting the efficacy of liver metastases after chemotherapy in colorectal cancer.

Official Title
-----------------
The Value of DWI-MRI(Diffusion-weighted Imaging) in Evaluating the Early Efficacy of Liver Metastasis in Colorectal Cancer

Conditions
-----------------
DWI-MRI

Intervention / Treatment
-----------------
* Device: Diffusion weighted magnetic resonance imaging


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: aged ≥18 years with histologically or cytologically confirmed advanced colorectal adenocarcinoma Eastern Cooperative Oncology Group performance status of 0 to 2 life expectancy of ≥ 3 months at least one measurable liver metastatic lesion in MRI (≥10mm) have adequate bone marrow, hepatic, and renal function previously received no palliative chemotherapy Exclusion Criteria: patients with previous chronic inflammatory bowel disease, chronic diarrhea or recurrent bowel obstruction patients with symptomatic brain metastases active clinical severe infection have contraindication of MRI screening

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Device Feasibility
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: DWI-MRI<br> | Device: Diffusion weighted magnetic resonance imaging<br>* The enrolled colorectal liver metastases patients will receive DWI-MRI screening to evaluate the liver metastases before the chemotherapy, after the first cycle of chemotherapy and in the regular efficacy evaluation time, respectively.<br>* Other names: DWI-MRI;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Response rate | the response rate predicted by DWI-MRI | 2 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression free survival |  | 2 months | 
| Overall survival |  | 2 months |
Left Ventricular Hypertrophy and Spironolactone in End Stage Renal Disease

Study Overview
=================
Brief Summary
-----------------
The hypothesis of this trial is to assess the effect of spironolactone on heart size and mass

Detailed Description
-----------------
Dialysis patients have significant morbidity and mortality associated with left ventricular hypertrophy and cardiac failure. Aldosterone may have an important role in the development of myocardial hypertrophy and remodeling. Animal studies have demonstrated beneficial effects of aldosterone antagonists on myocardial hypertrophy, and human studies have shown significant survival benefit in a non-dialysis population with congestive heart failure. This study evaluates the effect of spironolactone (an aldosterone receptor antagonist) on cardiac hypertrophy in the end-stage renal disease population.

Official Title
-----------------
Cardiac Magnetic Resonance Imaging in Hemodialysis Patients

Conditions
-----------------
Kidney Failure, Chronic

Intervention / Treatment
-----------------
* Drug: Spironolactone


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: hemodialysis patients Exclusion Criteria: non compliance hyperkalemia pregnancy expected survival less than 9 months

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: 1 group - no arms<br>no arm just error message | Drug: Spironolactone<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Left ventricular mass |  | 9 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Kidney Failure, Chronic, Hemodialysis, Spironolactone
Imaging Young Myeloma (IMAgerie JEune Myélome)

Study Overview
=================
Brief Summary
-----------------
Multicenter open-label prospective comparative study of PET-scan and MRI at the time of diagnosis, after 3 cycles of induction therapy (RVD) and at the completion of therapy.

Official Title
-----------------
Pharmacoeconomic and Clinical Prospective Comparison of PET-scan and MRI in Patients With de Novo Multiple Myeloma Less Than 65 Years of Age Treated According to IFM/DFCI 2009 Clinical Trial.

Conditions
-----------------
Multiple Myeloma

Intervention / Treatment
-----------------
* Procedure: PET scan
* Procedure: MRI


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: symptomatic de novo multiple myeloma less than 65 years of age enrolled in the IFM/DFCI clinical trial Exclusion Criteria: 66 years of age or more not eligible for high-dose therapy Cons-indications to MRI or PET-Scan

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: PET scan|Performed at diagnosis, after 3 cycles of induction therapy, and at completion of therapy|
|Procedure: MRI|Performed at diagnosis, after 3 cycles of induction therapy, and at completion of therapy|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with at least one lesion not detected on the MRI lesions |  | At diagnosis | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Negativity of the exam after 3 cycles of chemotherapy and just before the maintenance treatment |  | 3 months and 7 months | 
| Number of lesions at diagnosis |  | Inclusion (diagnosis) | 
| diffuse disease at diagnosis |  | Diagnosis time (inclusion) | 
| Direct costs of PET and MRI at diagnosis, after the first cycles of chemotherapy and before the maintenance treatment |  | Inclusion, 3 months and 7 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
MRI, PET-scan, multiple myeloma, prognosis, pharmacoeconomic analysis
Relationship Between Systemic Fatty Acid Availability and Insulin Sensitivity

Study Overview
=================
Brief Summary
-----------------
The investigators specific aim is to compare the relationship between systemic fatty acid availability and insulin sensitivity in a relatively homogenous population of obese adults. The investigators anticipate 1) greater systemic fatty acid availability will be associated with lower insulin sensitivity and 2) greater systemic fatty acid availability will be associated with greater accumulation of fatty acid intermediates and pro-inflammatory markers.

Conditions
-----------------
Obesity

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Body mass index [BMI]: 35-45 kg/m2; All women must be pre-menopausal; Non-exerciser (no regularly planned exercise/physical activity) Exclusion Criteria: Weight instability ≥ ±5 lbs. in past month; medications known to affect lipid and/or glucose metabolism; Pregnancy or actively breast feeding

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Obese Sedentary Adults, but otherwise healthy<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Insulin Sensitivity | A hyperinsulinemic-euglycemic clamp will be used to assess peripheral insulin sensitivity | 2-3 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Resting Metabolic Rate |  | 20-30 min | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
fatty acid metabolism, insulin sensitivity
Effect of Piezoelectric Alveolar Decortication on Post-Orthodontic Lower Incisors Stability: A Randomized Clinical Trial

Study Overview
=================
Brief Summary
-----------------
To assess the effect of piezocision on post-orthodontic lower anterior teeth stability as compared to fiberotomy and conventional Hawley retainers.

Official Title
-----------------
Effect of Piezoelectric Alveolar Decortication on Post-Orthodontic Lower Incisors Stability: A Randomized Clinical Trial

Conditions
-----------------
Retention

Intervention / Treatment
-----------------
* Procedure: Piezoelectric Alveolar Decortication, fibrotomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Individuals who had lower anterior irregularity (crowding, rotation, buccally or lingually displaced) will be selected. Good oral hygiene, healthy gingiva and no evidence of bone loss as seen on the radiograph. Healthy systemic conditions. Patients pass the growth spurt according to cervical vertebral maturation method as described by Baccetti et al. Availability of good quality records at pretreatment and post-treatment. Exclusion Criteria: Patients that has any signs of active periodontal disease or evidence of bone loss on the radiograph. Patients with systemic disease such as osteoporosis and diabetes. Smoking patients. Study casts did not include all mandibular permanent incisors, canines, and first molars.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: piezocision group<br>piezocision surgical procedure was done according to Dibart's et al, | Procedure: Piezoelectric Alveolar Decortication, fibrotomy<br> <br> |
| Experimental: fiberotomy group<br>the fiberotomy procedure followed Edward's et al | Procedure: Piezoelectric Alveolar Decortication, fibrotomy<br> <br> |
| No Intervention: control group<br>no intervention | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| lower incisors stability after 6 months | study models will be evaluated 6 months after debonding Incisor Irregularity Index of lower anterior teeth will be measured using a digital caliper | 6 months | 
| lower incisors stability after 12 months | study models will be evaluated 12 months after debonding Incisor Irregularity Index of lower anterior teeth will be measured using a digital caliper | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Retention; Relapse; Fibrotomy; Piezocision;
Comparison of Papillary Balloon Dilatation Vs.Sphincterotomy for Lithotripsy in Difficult Sphincterotomy or Distal CBD Tapering

Study Overview
=================
Brief Summary
-----------------
Compare endoscopic papillary balloon dilatation vs. endoscopic sphincterotomy for bile duct stones in: when sphincterotomy is difficult (periampullary diverticulum, prior sphincterotomy or Billroth II anastomosis) when there is distal CBD tapering.

Detailed Description
-----------------
Endoscopic papillary balloon dilatation is an alternative to endoscopic sphincterotomy for treating bile duct stones: easier and as effective. But... a higher risk of pancreatitis. Conditions including periampullary diverticulum, prior EST, Billroth-II anastomosis, or distal CBD tapering pose difficulty in EST and lithotripsy with increased risk of complications. Whether EPBD or EST is superior in efficacy or safety under such circumstances is not clear.

Official Title
-----------------
Comparison of Endoscopic Papillary Balloon Dilatation and Sphincterotomy for CBD Stones With Difficult Sphincterotomy or Distal CBD Tapering

Conditions
-----------------
Choledocholithiasis

Intervention / Treatment
-----------------
* Procedure: Endoscopic papillary balloon dilatation
* Procedure: Endoscopic sphincterotomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Choledocholithiasis with Difficult sphincterotomy:periampullary diverticulum, prior sphincterotomy or Billroth II anastomosis or distal CBD tapering. Exclusion Criteria: Patients in whom no endoscopic papillary balloon dilatation or endoscopic sphincterotomy was performed for lithotripsy

Ages Eligible for Study
-----------------
Minimum Age: 0 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Endoscopic papillary balloon dilatation|nan|
|Procedure: Endoscopic sphincterotomy|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Endoscopic papillary balloon dilatation, Endoscopic sphincterotomy