Ropivacaine Volume for Ultrasound-guided Retrograde Infraclavicular Brachial Plexus Block

Study Overview
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Brief Summary
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The retrograde infraclavicular brachial plexus block has been proved an effective and safe approach. Realtime ultrasound guide will facilitate a successful peripheral nerve block. The purpose of this study was to determine the medium effective volume required to produce an effective retrograde infraclavicular block using an ultrasound (US)-guided technique.

Detailed Description
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Thirty adults undergoing elective upper limb surgery received an US-guided retrograde infraclavicular block. The initial concentration of 0.5% ropivacaine injected was 30 ml, which was subsequently varied at a ratio of 1: 1.2 for each consecutive patient according to the response of the previous patient. The medium effective volume (EV50) was determined using the Dixon and Massey up-and-down method. The effective volume in 95% of patients (EV95) was calculated using probit regression.

Official Title
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Ropivacaine Volume for Ultrasound-guided Retrograde Infraclavicular Brachial Plexus Block

Conditions
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Upper Extremity Injury Trauma

Intervention / Treatment
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* Procedure: appropriate volume of 0.5% ropivacaine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Elected upper extremity operations BMI 17 30kg/m2 ASA I/II Exclusion Criteria: Infection at injection site Sepsis Coagulation Dysfunction Phrenic nerve palsy Pneumothorax Recurrent laryngeal nerve palsy Clavicle fracture combined with nerve damage

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: ropivacaine volume titration<br> | Procedure: appropriate volume of 0.5% ropivacaine<br>* initial concentration: 30 ml, subsequently varied at a ratio of 1: 1.2 for each consecutive patient according to the response of the previous patient, until 5 up-and-down cycles completed.<br>* Other names: Naropin;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| VAS of brachial plexus innervated area | effect and side effects of the present block approach for brachial plexus. | 20 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| medium effective ropivacaine volume | The initial concentration of 0.5% ropivacaine injected was 30 ml, which was subsequently varied at a ratio of 1: 1.2 for each consecutive patient according to the response of the previous patient. The medium effective volume (EV50) was determined using the Dixon and Massey up-and-down method. EV95 was calculated using probit regression. | about 2 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Anesthetic techniques,regional, Drug delivery,volume, Anesthetic, local: ropivacaine