Substance-focused SBI as a Complement to Internet-based Psychiatric Treatment: RCT

Study Overview
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Brief Summary
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Objectives: This study evaluates the efficacy of eScreen for internet psychiatry patients treated for major depressive disorder, panic anxiety and social phobia. The eScreen brief Internet intervention for problematic alcohol and drug use offers self-screening, in-depth self-reporting, personalized feedback and treatment recommendations as well as an electronic diary. Progress over time is shown in diagrams detailing consumption levels. Method: This is a two-armed randomized controlled design, measuring outcomes in terms of changes in problematic alcohol use up to one year after study recruitment. Participants with problematic alcohol use (AUDIT >7 for men and >5 for women) and/or problematic drug use (DUDIT > 1 for both men and women) are randomized into one of two groups: T1, eScreen referral or Control group. Outcomes on alcohol and drug use as well as health-related symptoms are assessed after 3, 6 and 12 months. The hypothesis is that the group receiving the eScreen intervention will reduce their alcohol/drug use to a larger extent than the control group at follow-up compared to the baseline level.

Detailed Description
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This study evaluated the efficacy of eScreen for internet psychiatry patients treated for major depressive disorder, panic anxiety and social phobia. The eScreen brief Internet intervention for problematic alcohol and drug use offers self-screening, in-depth self-reporting, personalized feedback and treatment recommendations as well as an electronic diary. Progress over time is shown in diagrams detailing consumption levels. The design was a two-armed randomized controlled design, measuring outcomes in terms of changes in problematic alcohol use up to one year after study recruitment. Participants with problematic alcohol use (AUDIT >7 for men and >5 for women) and/or problematic drug use (DUDIT > 1 for both men and women) were randomized into one of two groups: T1, eScreen referral or Control group. Outcomes on alcohol and drug use as well as health-related symptoms are assessed after 3, 6 and 12 months. The hypothesis was that the group receiving the eScreen intervention would reduce their alcohol/drug use to a larger extent than the control group at follow-up compared to the baseline level. The results have not yet been analyzed due to technical issues. However, qualitative interviews have been conducted with participants and our intention is to publish the qualitative results in tandem with the quantitative results available.

Official Title
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Substance-use Focused Screening and Brief Intervention as a Complement to Internet-based Psychiatric Treatment for Depression, Panic Disorder or Social Phobia: A Randomized Controlled Trial

Conditions
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Substance Use Disorders (SUD)

Intervention / Treatment
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* Behavioral: eScreen
* Behavioral: Assessment only of alcohol and drug use.
* Behavioral: Internet-based treatment for depression or anxiety


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: AUDIT >7 for men and AUDIT >5 for women, and/or DUDIT >0 Exclusion Criteria: DUDIT = 0 and AUDIT <8 (men) or <6 (women)

Ages Eligible for Study
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Minimum Age: 15 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: eScreen<br>Web based self-monitoring of problematic alcohol and drug use, and Internet-based treatment for depression or anxiety | Behavioral: eScreen<br>* Access to the eScreen platform offering assessment of alcohol and drug use, with automated feedback on problematic or non-problematic use. Follow-up over time based on user needs.<br>Behavioral: Internet-based treatment for depression or anxiety<br>* Internet-based treatment for primary diagnoses of depression, panic anxiety or social phobia.<br>|
| Experimental: Control<br>Assessment only of alcohol and drug use and Internet-based treatment for depression or anxiety | Behavioral: Assessment only of alcohol and drug use.<br>* Assessment of alcohol and drug use at baseline and follow-up.<br>Behavioral: Internet-based treatment for depression or anxiety<br>* Internet-based treatment for primary diagnoses of depression, panic anxiety or social phobia.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in the total AUDIT-C score | The primary outcome measure for this trial is the change in the total AUDIT score for the first three AUDIT questions, as a measure of alcohol consumption only, referred to as the AUDIT-C. | 3, 6 and 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Alcohol Use Disorders Identification Test (AUDIT) | Change in total AUDIT score, as a summarized measure of alcohol use (including alcohol consumption and alcohol-related problems). | 3, 6 and 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Randomized Controlled Trial, Alcohol, Drugs, Internet, Screening, Brief intervention