Narrow Band Imaging (NBI) Under Electronic Bronchoscope in Lung Cancer

Study Overview
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Brief Summary
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Narrow-Band Imaging (NBI) is useful to better demarcate the superficial extent of central type of lung cancer, but its sensitivity and specificity in clinical practice were little studied. This study aimed to investigate the diagnostic effects of NBI in suspected patients with central lung cancer and its application in staging diagnosis of central lung cancer.

Detailed Description
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With high morbidity and mortality, lung cancer is one of the most common tumors in the world. Therefore, early detection, accurate diagnosis and staging division can effectively guide clinical interventions, thereby improving patient survival. Narrowband imaging under electronic bronchoscope (NBI) is an emerging optical image emphasis technology that can enhance the contrast between the mucosal surface and underlying blood vessels, specifically display the distribution of blood vessels, and highlight the subtle changes in mucosal structure. Meanwhile, it can reduce unnecessary biopsy with low risk and costs. In recent years, NBI technology has gradually begun to show its unique advantages in the diagnosis of gastric cancer, esophageal cancer, nasopharyngeal cancer, and bladder cancer. The purpose of this study is to explore the diagnostic value of NBI under electronic bronchoscopy for early detection and accurate diagnosis of lung cancer, and to provide a more economical, safer and more efficient diagnosis option for lung cancer patients.

Official Title
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Application of Narrow Band Imaging (NBI) Under Electronic Bronchoscope in the Diagnosis and Staging of Lung Cancer

Conditions
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Lung Cancer, Malignant Airway Obstruction

Intervention / Treatment
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* Procedure: NBI and interventional bronchoscopy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Patients had a history or current central lung cancer Exclusion Criteria: - NONE

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| NBI PATIENT<br>Diagnostic Test: NBI in combination with electronic bronchoscope | Procedure: NBI and interventional bronchoscopy<br>* NBI used to enhance the contrast between the mucosal surface and underlying blood vessels<br>|
| Non-NBI PATIENT<br>Diagnostic Test: Electronic bronchoscope without NBI | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The specificity of diagnosis of NBI plus electronic bronchoscopy in central type lung cancer | Abnormal blood vessels or lack of staining is defined as suspected lesions. All the suspected lesions were biopsied. | 4 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The sensitivity, positive predictive value, and negative predictive value. | Abnormal blood vessels or lack of staining is defined as suspected lesions. All the suspected lesions were biopsied. | 4 months |