Impact of Coffeeberry Extract on Skill Performance During Simulated Match Play in Academy Football Players

Study Overview
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Brief Summary
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This study of soccer skill performance has three objectives: Compare effects of coffeeberry (300mg) and placebo ingestion on dribbling speed and precision, passing speed and accuracy, and sprint speed during a full simulated soccer match. Compare effects of coffeeberry (300mg) and placebo ingestion on subjective measures (mental / physical energy and activation-deactivation (feelings or mood) during a full simulated soccer match. Compare effects of coffeeberry (300mg) and placebo ingestion on chlorogenic acid (CGA) and caffeine metabolites in the blood 1-hour post ingestion, and other blood metabolites (glucose/lactate) throughout the simulated soccer match.

Official Title
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Impact of Coffeeberry Extract on Skill Performance During Simulated Match Play in Academy Football Players

Conditions
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Skill Performance, Soccer Performance, Coffeeberry Effects

Intervention / Treatment
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* Other: Beverage


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Provide valid informed consent prior to any study procedure Male soccer players age 16 to 28 years. >= 5-year soccer playing experience >= 1-year regularly soccer training Free of injuries Willing to avoid alcohol in the 48-h period prior to all visits Willing to avoid caffeinated products and apples, berries/cherries for 24-h prior to all visits Willing to record food intake over the 48-h period prior to the first trial and replicate for second trial Willing to abstain from strenuous physical activity for 24-h before all visits Exclusion Criteria: Smoking Cardiovascular diseases Diabetes or other metabolic disease • Hypertension (>140/>90 mm Hg) Presence of injuries Major illnesses or surgery in prior 90 days Participation in another clinical trial in the past month

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 28 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Coffeeberry beverage<br>300 ml drink containing 300 mg coffeeberry extract | Other: Beverage<br>* Free from added carbohydrates (contain 1g CHO only) and electrolytes are absent.<br>|
| Placebo Comparator: Color and flavor matched beverage<br>300 ml drink (0 mg coffeeberry extract, 0 mg caffeine) | Other: Beverage<br>* Free from added carbohydrates (contain 1g CHO only) and electrolytes are absent.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dribbling speed | m/sec, increase would be better. Simulated soccer match in an indoor gym with pre-set targets. | Change from pre-dose baseline through end of match 3.5 hours post consumption at multiple intervals each half of match | 
| Dribbling precision | Meters, more accuracy would be better. Simulated soccer match in an indoor gym with pre-set targets. | Change from pre-dose baseline through end of match 3.5 hours post consumption at multiple intervals each half of match | 
| Passing accuracy | 1 to 10 scale, a higher score would be better. Simulated soccer match in an indoor gym with pre-set targets. | Change from pre-dose baseline through end of match 3.5 hours post consumption at multiple intervals each half of match. | 
| Passing speed | km/h, increased passing speed would be better. Simulated soccer match in an indoor gym with pre-set targets. | Change from pre-dose baseline through end of match 3.5 hours post consumption at multiple intervals each half of match | 
| Sprint speed. | m/sec, increased sprint speed would be better. In indoor gym with marked course. | Change from pre-dose baseline through end of match 3.5 hours post consumption at multiple intervals each half of match | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood analyte: Chlorogenic acid (CGA) | mmol/L to evaluate primary outcomes. n.a. for placebo. Capillary blood draw for frozen plasma analysis | Pre-dose baseline, 60 minutes post-dose, half-time, and end of match (3.5 hours) | 
| Blood analyte: Caffeine metabolites | ug/ml, to evaluate primary outcomes. n.a. for placebo. Capillary blood draw for frozen plasma analysis | Pre-dose baseline, 60 minutes post-dose, half-time, and end of match (3.5 hours) | 
| Blood analyte: Glucose | mmol/L, more regulated would be better. Capillary blood draw for frozen plasma analysis | Pre-dose baseline, 60 minutes post-dose, half-time, and end of match (3.5 hours) | 
| Blood analyte: Lactate | mmol/L, lower (delayed rise) would be better. Capillary blood draw for frozen plasma analysis | Pre-dose baseline, 60 minutes post-dose, half-time, and end of match (3.5 hours) | 
| Rating of perceived exertion (RPE) | By Borg scale, rated 6 to 20, very very light to very very hard. Lower values would be better | Half-time and end of match (3.5 hours) | 
| Activation-deactivation (feelings or mood) | Checklist of 20 feelings using a 4 point scale from definitely do feel to definitely don't feel. More relaxed feelings or in a better mood would be better. | Pre-dose baseline, 60 minutes post-dose, half-time, and end of match (3.5 hours) | 
| Mental energy | Visual Analog Scale (VAS), vertical marking on 100 mm horizontal line. Higher energy would be better | Pre-dose baseline, 60 minutes post-dose, half-time, and end of match (3.5 hours) | 
| Physical energy | Visual Analog Scale (VAS), vertical marking on 100 mm horizontal line. Higher energy would be better | Pre-dose baseline, 60 minutes post-dose, half-time, and end of match (3.5 hours) | 
| Gut comfort | Visual Analog Scale (VAS), vertical marking on 100 mm horizontal line. No or less nausea, fullness or bloating would be better | Pre-dose baseline, 60 minutes post-dose, half-time, and end of match (3.5 hours) | 
| Heart rate | By electronic reading. Lower would be better. | Continuous from pre-dose baseline through end of match (3.5 hours) | 
| Hydration status | Urine osmolality in mOsm/kg change in concentration pre- vs. post-exercise | Pre-dose baseline and end of match (3.5 hours) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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coffeeberry, caffeine, polyphenols, chlorogenic acid, exercise, soccer, football, skill, performance