linjc16/ctgov huggingface dataset:
The Effect of an Online Exercise Course on the Increase of Elders' Regular Exercise Intention

Study Overview
=================
Brief Summary
-----------------
The effect of an online exercise course on the increase of elders' regular exercise intention.

Detailed Description
-----------------
This project expects that after the four-week exercise course intervention, the elderly can increase their knowledge about exercise and experience the benefits of exercise, enhance the intention of the elderly to exercise regularly, and reduce the chance of the elderly falling due to muscle loss and causing related diseases.

Official Title
-----------------
The Effect of an Online Exercise Course on the Increase of Elders' Regular Exercise Intention

Conditions
-----------------
Elderly, Exercise Training

Intervention / Treatment
-----------------
* Behavioral: The effect of an online exercise course on the increase of elders' regular exercise intention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The patients from outpatient clinic for elderly health examination. Exclusion Criteria: The elderly who has severe hearing impairments. The elderly who has severe visual impairments. The elderly who has severe health problems. The elderly who need to be quarantined. The elderly who is living alone.

Ages Eligible for Study
-----------------
Minimum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: The effect of an online exercise course on the increase of elders' regular exercise intention<br>The effect of an online exercise course on the increase of elders' regular exercise intention. | Behavioral: The effect of an online exercise course on the increase of elders' regular exercise intention<br>* The intervention of an online exercise course which 2 days a week for 4 weeks to increase the elders' regular exercise intention.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline on the survey of questionnaire | Change from baseline of exercise intention on the survey of questionnaire | Baseline, within 2 weeks after the end of the intervention | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
exercise, older adults
Description of the Use of Subcutaneous Acetaminophen in Palliative Care Unit in France: Descriptive Questionnaire Survey

Study Overview
=================
Brief Summary
-----------------
Acetaminophen is a drug commonly used in palliative care unit, for its antalgic and antipyretic effects. Several administration routes are possible but the use of the sub-cutaneous route is actually not supported by recommandations.

Official Title
-----------------
Description of the Use of Subcutaneous Acetaminophen in Palliative Care Unit

Conditions
-----------------
Pain

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: doctors responsible for palliative care unit in France Exclusion Criteria: -
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| knowledge about the use of subcutaneous acetaminophen in palliative care unit. | questionnaire | day 1 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Palliative care; Acetaminophen; Subcutaneous route; Pain treatment
Glycemic Response Testing

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to assess whether added food ingredient(s) affect glycemic responses to a liquid meal tolerance test (LMTT).

Official Title
-----------------
Glycaemic Response Testing

Conditions
-----------------
Glycemic Index, Glycemic Response

Intervention / Treatment
-----------------
* Other: Dietary Intervention
* Other: Dietary Intervention
* Other: Dietary Intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male or female (not less than 40% males or females Non-smoker Aged 18 to 55 years Have a body mass index between 18.5 to 29.99 kg/m2 Healthy, non-diabetic, no gastric bypass surgery Not allergic to mustard, dairy or soy Having a fasting plasma glucose (finger stick) <100 mg/dl (<5.5 mmol/L) Willing and able to provide written informed consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Control Test Drink<br>control drink | Other: Dietary Intervention<br>* 300 ml of liquid food product<br>|
| Experimental: Experimental Test Drink 1<br>control drink containing ingredient 1 | Other: Dietary Intervention<br>* 300 ml of liquid food product<br>|
| Experimental: Experimental Test Drink 2<br>Control drink containing ingredient 2 | Other: Dietary Intervention<br>* 300 ml of liquid food product<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glycemic Response Measured as the Positive Incremental Area Under the Time-concentration Curve(iAUC) Calculated From Individual Glucose Measurements Upon Consumption of Control and Experimental Test Food Products | The individual glucose measurements were collected at baseline (prior to consumption of each test food product and 15, 30, 45, 60, 90 and 120 minutes following the initiation of consumption of each test food product. The positive incremental area under the time-concentration curve (iAUC) was then calculated for the entire 120 minutes after consumption of each test food product. The results show the differential treatment-related effect on the time-concentration curve (iAUC) for the entire 120 minutes post consumption of each test food product. | 0-120 minutes |
First Event of Infection by HIV-1 of Uterine Vaginal Tissue

Study Overview
=================
Brief Summary
-----------------
This non-interventional study aims to characterize the cells infected with HIV over time in different types of vagino-uterine tissue.

Official Title
-----------------
Inhibition by the Antibody, First Event of Infection by HIV-1 of Uterine Vaginal Tissue

Conditions
-----------------
HIV Infection of the Uterine Vaginal Tissues

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients whose age ≤50 years and ≥18 years Patients for which surgery like laparoscopy or hysterectomy is necessary as part of a benign pathology. Exclusion Criteria: Patients under 18 years

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| identification of the first HIV-infected cells by a histological analysis |  | after surgery, up to 3 weks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
HIV infection, vaginal tissues, uterine tissues
Effects of Supplementary Oxygen on Dyspnoea and Exercise Tolerance in COPD Patients Given LTOT

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to evaluate effects of supplementary oxygen during exercise on dyspnoea and exercise tolerance in COPD-patients given long-time oxygen treatment

Conditions
-----------------
COPD

Intervention / Treatment
-----------------
* Drug: oxygen


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: COPD patients (male/female)given long-term oxygen treatment Able to perform two separate walking tests Exclusion Criteria: Severe heart failure
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: oxygen|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| dyspnea |  |  | 
| exercise tolerance |  |  |
NSAID vs Steroid in Trabeculectomy Wound Management

Study Overview
=================
Brief Summary
-----------------
This study will examine the efficacy of steroid vs NSAID treatment in relation to trabeculectomy wound management. Eligible study participants will be randomized to receive either steroid or NSAID topical treatment one week post-trabeculectomy. Each group will dose with their assigned study treatment until three months post-trabeculectomy. Study participants will be followed for twelve months post-trabeculectomy.

Official Title
-----------------
An Investigator-Initiated Multicenter Prospective Clinical Trial to Examine the Efficacy of Peri-operative NSAID vs Steroid Treatment in Trabeculectomy Wound Management

Conditions
-----------------
Glaucoma

Intervention / Treatment
-----------------
* Drug: Bromfenac 0.07% Oph Susp
* Drug: Dexamethasone


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult patients over the age of 18 years Uncontrolled open angle glaucoma Scheduled to undergo stand-alone trabeculectomy No previous incisional glaucoma surgery No ocular surgery of any kind in prior 6 months Exclusion Criteria: steroids and/or NSAIDs contraindicated poor corneal epithelial health

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: NSAID<br>Bromfenac 0.07% Oph Susp: used from one week post-op to three months post-op | Drug: Bromfenac 0.07% Oph Susp<br>* Bromfenac 0.07% Oph Susp to be used post-operatively (week 1 to month 3) by one treatment group.<br>* Other names: Bromfenac;|
| Active Comparator: Steroid<br>Dexamethasone: used from one week post-op to three months post-op | Drug: Dexamethasone<br>* Topical dexamethasone to be used by all study participants for one week pre-trabeculectomy and by all study participants for one week post-trabeculectomy. At one week post-op, one of the treatment groups will continue to dose with dexamethasone.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Target IOP | the proportion of patients achieving a target IOP range (≤21, ≤18, ≤15 or ≤12 mmHg) at 12 months post-operatively | 12 months |
Effect Of Rifampin On Pharmacokinetics Of Sitaxsentan

Study Overview
=================
Brief Summary
-----------------
This study will assess how rifampin will affect the blood levels of sitaxsentan. Safety of sitaxsentan given alone and with rifampin will also be assessed.

Official Title
-----------------
A Phase 1, Open Label, Fixed Sequence Design, Multiple Dose Study To Assess The Effect Of Rifampin On The Pharmacokinetics Of Sitaxsentan In Healthy Subjects

Conditions
-----------------
Pulmonary Arterial Hypertension

Intervention / Treatment
-----------------
* Drug: Sitaxsentan alone
* Drug: Sitaxsentan
* Drug: Rifampin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy male subjects and/or women of non-child bearing potential. Subjects between the ages of 21 and 55 years, inclusive. Signed informed consent. Exclusion Criteria: Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease. Has hepatic dysfunction. Has history of excessive alcohol and tobacco use.

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Sitaxsentan<br> | Drug: Sitaxsentan alone<br>* Days 1-5: Sitaxsentan tablet, 100 mg, q24 h (once a day)<br>|
| Experimental: Sitaxsentan plus Rifampin<br> | Drug: Sitaxsentan<br>* Days 6-12: Sitaxsentan tablet, 100 mg, q24h (once a day)<br>Drug: Rifampin<br>* Days 6-12: Rifampin capsule, 600 mg, q24h (once a day)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of Peak Plasma Concentrations of sitaxsentan co-administered with rifampin versus sitaxsentan administered alone. |  | 24 hours | 
| Comparison of Area Under the Curve of sitaxsentan co-administered with rifampin versus sitaxsentan administered alone. |  | 24 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Sitaxsentan, Rifampin, Drug Interaction, Pharmacokinetics
A Combined Surgical and Medical Approach in Mild Sleep Apnea

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to investigate wether the adjuvant (postoperative) administration of acetazolamide can improve the surgical results after uvulopalatopharyngoplasty in patients with mild sleep apnea.

Conditions
-----------------
Sleep Apnea

Intervention / Treatment
-----------------
* Drug: acetazolamide
* Drug: placebo
* Procedure: uvulopalatopharygoplasty


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 5 ≤ Apnea Hypopnea Index (AHI) < 20 Socially disturbing snoring: Visual Analogue Scale (VAS)snoring > 6/10 Based on clinical examination and polysomnography, patient is regarded eligible for uvulopalatopharyngoplasty (UPPP) Exclusion Criteria: Previous surgical treatment for sleep-disordered breathing. Periodic Limb Movement Disorder (PLMD) with arousals and other reasons possibly explaining the Excessive Daytime Sleepiness (EDS) based on Epworth Sleepiness Scale (ESS). Forced expiratory volume in 1 second (FEV1) < 80 % pred. Echocardiography: ejectionfraction < 35 % or dyastolic dysfunction grade 2 or more.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: acetazolamide|nan|
|Drug: placebo|nan|
|Procedure: uvulopalatopharygoplasty|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Polysomnographic parameters |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| subjective sleepiness |  |  | 
| subjective snoring |  |  | 
| satisfaction |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
sleep apnea, snoring, acetazolamide, uvulopalatopharyngoplasty, daytime sleepiness, upper airway
Effects of Salt Intake on the Nervous Systems of Patients With Salt-Sensitive High Blood Pressure

Study Overview
=================
Brief Summary
-----------------
Some patients with high blood pressure can experience an increase of blood pressure by 10 percent or more by taking in salt. These patients are referred to as having salt-sensitive (SS) hypertension. Previous studies conducted on patients with salt sensitive hypertension suggest that their portion of the nervous system responsible for maintaining normal blood pressure (autonomic nervous system) may respond differently to salt than patients with non-salt sensitive (NSS) hypertension. This study is designed to examine the response of the nervous system to high doses of salt in patients with salt-sensitive hypertension and patients with non-salt sensitive hypertension.

Detailed Description
-----------------
A subset of patients with idiopathic hypertension shows an increase in blood pressure of 10 percent or more in response to salt-loading and have been termed salt-sensitive (SS). Limited studies of adrenergic function in response to salt-loading suggest that the response of SS patients may differ from that of non-salt sensitive (NSS) patients. The present studies were designed to examine the response of the adrenergic and dopaminergic systems to salt-loading in SS and NSS patients with idiopathic hypertension.

Official Title
-----------------
The Function of Dopaminergic and Noradrenergic Systems in Salt-Sensitive Hypertension: The Effects of Changes in Sodium Intake

Conditions
-----------------
Hyperaldosteronism, Hypertension

Participation Criteria
=================
Eligibility Criteria
-----------------
Eligibility criteria not identified in protocol.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Adrenergic Nervous System, Dopaminergic Nervous System, Salt-Sensitive Hypertension, Hypertension, Primary Aldosteronism
Dopamine Reuptake Inhibitors of Cocaine Abuse - 1

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate dopamine reuptake inhibitors for cocaine abuse.

Official Title
-----------------
Dopamine Reuptake Inhibitors of Cocaine Abuse

Conditions
-----------------
Cocaine-Related Disorders

Intervention / Treatment
-----------------
* Drug: Bupropion


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Bupropion|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Side effects |  |  | 
| Cocaine effects |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cocaine-Related Disorders
Accuracy of Cardiac Acoustic Biomarkers Recorded by the Wearable Cardioverter Defibrillator

Study Overview
=================
Brief Summary
-----------------
Evaluate data accuracy of cardiac acoustic biomarkers (CABs) recorded by the Wearable Cardioverter Defibrillator (WCD) as compared to the AUDICOR AM acoustic cardiography recorder.

Detailed Description
-----------------
Single arm, prospective, non significant risk device study to evaluate data accuracy of cardiac acoustic biomarkers (CABs) recorded by the Wearable Cardioverter Defibrillator (WCD) compared with the CABs data simultaneously recorded by an acoustic cardiography recorder, the AUDICOR AM device.

Official Title
-----------------
Accuracy of Cardiac Acoustic Biomarkers Recorded by the Wearable Cardioverter Defibrillator

Conditions
-----------------
Heart Failure

Intervention / Treatment
-----------------
* Device: Wearable Cardioverter Defibrillator


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years of age or older heart failure or a history of heart failure ischemic or non-ischemic cardiomyopathy ejection Fraction less than or equal to 40% as measured within the last 6 months Exclusion Criteria: implanted left ventricular assist device pacemaker dependency currently hospitalized atrial fibrillation on their last ECG or having an irregularly irregular pulse

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Heart Failure Patients<br>Simultaneous recordings of cardiac acoustic biomarkers (CABs) by the Wearable Cardioverter Defibrillator and the AUDICOR AM | Device: Wearable Cardioverter Defibrillator<br>* Use of the Wearable Cardioverter Defibrillator and AUDICOR AM to evaluate accuracy of cardiac acoustic biomarker recordings.<br>* Other names: AUDICOR AM;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CABs comparison | Simultaneous CABs recordings from the AUDICOR and WCD devices will be compared | 2 hours |