Time Gain in the Diagnosis Myocardial Infarction by Troponin Point of Care Testing in the Emergency Room

Study Overview
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Brief Summary
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The investigators prospectively want to compare 3 clinical tests for measuring blood troponin levels in patients presenting to the emergency room with thoracic pain probably related to a myocardial infarction with regard to the time necessary to obtain the test results. The tests are one laboratory based test and two point of care tests.

Detailed Description
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Thoracic pain can be caused by a myocardial infarction. The diagnosis of a myocardial infarction can be made by an ECG (ST-elevation myocardial infarction, STEMI). However, some myocardial infarctions can also occur without ST-elevations on the ECG (non-ST-elevation myocardial infarction, non-STEMI). In the latter case, a quick acquisition of blood troponin levels is necessary to coin the diagnosis and initiate treatment. Therefore, the investigators prospectively want to compare 3 clinical tests for measuring blood troponin levels in patients presenting to the emergency room with thoracic pain probably related to a non-STEMI with regard to the time necessary to obtain the test results. The 3 tests are: A laboratory based test: Roche Cobas E 602 A point of care test: Radiometer AQT 90 Flex A point of care test: Philips Minicare I-20 The measured timeframe is the time between venipuncture to the point the test results are known.

Official Title
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Time Gain in the Diagnosis of Non-ST Elevation Myocardial Infarction by Troponin Point of Care Testing in the Emergency Room

Conditions
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Non STEMI, Angina Pectoris, Angina, Stable, Angina, Unstable, Angina, Prinzmetal's

Intervention / Treatment
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* Device: Laboratory based troponin test
* Device: Point of care based troponin test 1
* Device: Point of care based troponin test 2


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Thoracic pain Exclusion Criteria: Unable to give informed consent

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Thoracic pain<br>Patients presenting to the emergency room with thoracic pain probably due to a non-STEMI | Device: Laboratory based troponin test<br>* acquisition of blood troponin level by Roche Cobas E 603<br>Device: Point of care based troponin test 1<br>* acquisition of blood troponin level by Radiometer EQT 90 Flex<br>Device: Point of care based troponin test 2<br>* acquisition of blood troponin level by Philips Minicare I-20<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| time delay until troponin test results are known |  | From the time of venipuncture to the time the troponin test results are known: up to 6 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Troponin, Point of care test, myocardial infarction