Monitoring Brain Waves in Response to Visual and/or Auditory Stimulation in Parkinson's Disease Patients

Study Overview
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Brief Summary
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Voltage fluctuation as a result of brain activity will be recorded into the computer using an EEG device.

Detailed Description
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Patients with Parkinson's disease may have gait disturbances including freezing of gait. Visual and auditory stimuli may improve gait. Investigators will analyze brain wave during walking while giving the subject different stimuli. The voltage fluctuation (in hundreds of microvolts) will be recorded using the EEG cap and amplifier into a computer.

Official Title
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Monitoring Brain Waves in Response to Visual and/or Auditory Stimulation in Parkinson's Disease Patients

Conditions
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Parkinson's Disease

Intervention / Treatment
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* Behavioral: Baseline
* Behavioral: visual stimuli
* Behavioral: Auditory stimuli
* Behavioral: Visual and auditory stimuli


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • Patients with Parkinson's disease that are ambulatory and can sign a written informed consent Exclusion Criteria: Patients with Parkinson's disease who are not ambulatory Patients with dementia Patients that are blind Patients that have severe hearing impairment

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Baseline<br>Patients will walk naturally with EEG measuring brain waves | |
| Experimental: Visual stimuli<br>Patients will walk naturally with EEG measuring brain waves while seeing a grid through glasses | Behavioral: Baseline<br>* Patients will walk naturally with EEG measuring brain waves<br>Behavioral: visual stimuli<br>* Patients will walk naturally with EEG measuring brain waves while seeing a grid through glasses<br>|
| Experimental: Auditory stimuli<br>Patients will walk naturally with EEG measuring brain waves while hearing an auditory stimuli | Behavioral: Baseline<br>* Patients will walk naturally with EEG measuring brain waves<br>Behavioral: Auditory stimuli<br>* Patients will walk naturally with EEG measuring brain waves while hearing an auditory stimuli<br>|
| Experimental: Visual and auditory stimuli<br>Patients will walk naturally with EEG measuring brain waves while seeing a grid through glasses and hearing an auditory stimuli simultaneously | Behavioral: Baseline<br>* Patients will walk naturally with EEG measuring brain waves<br>Behavioral: Visual and auditory stimuli<br>* Patients will walk naturally with EEG measuring brain waves while seeing a grid through glasses and hearing an auditory stimuli simultaneously<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Voltage fluctuation resulting from brain activity after visual stimuli | Change in brain wave activity after visual stimuli as compared with baseline measured in tens of micro-volts per second. | One hour | 
| Voltage fluctuation resulting from brain activity after auditory stimuli | Change in brain wave activity after auditory stimuli as compared with baseline measured in tens of micro-volts per second. | One hour | 
| Voltage fluctuation resulting from brain activity after visual and auditory stimuli | Change in brain wave activity after visual and auditory stimuli as compared with baseline measured in tens of micro-volts per second. | One hour |