Respiratory Variations for Assessing Blood Withdrawal 2

Study Overview
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Brief Summary
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OBJECTIVES: To investigate whether respiratory variations of the inferior vena cava (ΔIVC) and internal jugular vein (ΔIJV) diameters during standardized breathing (ΔIVCST and ΔIJVST) increase after a therapeutic bleeding in spontaneously breathing and obese patients with dysmetabolic hyperferricemia. DESIGN: Prospective, monocentric study in the EFS Nord-de-France blood center. PATIENTS: Obese patients with dysmetabolic hyperferricemia undergoing a therapeutic bleeding. INTERVENTIONS: The investigators performed ultrasound measures and collected clinical parameters before and after a therapeutic bleeding, during a standardized respiratory maneuver. MAIN OUTCOME AND MEASURES: The primary endpoint was the ΔIVCST change induced by a 300 to 500ml therapeutic bleeding. The investigators measured the minimal and maximal IVC and IJV diameters during a standardized respiratory maneuver. ΔIVCST and ΔIJVST were calculated as follows: [(maximal diameter - minimal diameter)/maximal diameter].100.

Official Title
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Respiratory Variations in Diameters of the Inferior Vena Cava and the Internal Jugular Vein to Assess Blood Withdrawal in Patients With Dysmetabolic Hyperferritinemia

Conditions
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Obese, Dysmetabolic Syndrome, Hyperferritinemia

Intervention / Treatment
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* Procedure: echography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adult patients of > or equal 18 years dysmetabolic hyperferritinemia undergoing a therapeutic blood withdrawal health insured obese (body mass index > or equal 30Kg/m²) Exclusion Criteria: pregnancy transthoracic echogenicity unsuitable for measuring the inferior vena cava diameters clinical signs of active exhalation

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| obese patients with dysmetabolic hyperferritinemia<br>PATIENTS: obese patients with dysmetabolic hyperferritinemia undergoing a therapeutic bleeding. INTERVENTIONS: The investigators performed ultrasound measurements (echography) and collected clinical parameters before and after a 300 to 500ml therapeutic bleeding, during a standardized respiratory maneuver. | Procedure: echography<br>* The inferior vena cava and the internal jugular vein diameters were measured by echography before and after blood withdrawal during a standardized respiratory maneuver<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| blood withdrawal-induced changes in the respiratory variations of the inferior vena cava during a standardized respiratory maneuver (ΔIVCST) | The primary endpoint was the ΔIVCST change induced by a 300 to 500ml therapeutic bleeding. The investigators measured the minimal and maximal IVC diameters during a standardized ventilation. ΔIVCST was calculated as follows: [(maximal diameter - minimal diameter)/maximal diameter].100. | during a standardized respiratory maneuver, an average 1 hour maximum | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| blood withdrawal-induced changes in the respiratory variations of the internal jugular vein during a standardized respiratory maneuver (ΔIJVST) | The primary endpoint was the ΔIJVST change induced by a 300 to 500ml therapeutic bleeding. The investigators measured the minimal and maximal IJV diameters during a standardized ventilation. ΔIJVST was calculated as follows: [(maximal diameter - minimal diameter)/maximal diameter].100. | during a standardized respiratory maneuver, an average 1 hour maximum | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hyperferritinemia, dysmetabolic hyperferritinemia, obese, blood withdrawal, respiratory variations, inferior vena cava, internal jugular vein, ultrasound, ultrasonography, echography