Diagnostic Performance of Antenatal Ultrasound in the Localization of Intestinal Structures Involved in Malrotation With a Higher-risk of Volvulus

Study Overview
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Brief Summary
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The aims of this study are: To assess the performance of third-trimester ultrasound scan in the localization of intestinal structures (small bowel, gut, mesenteric vessels..) involved in malrotations with a higher-risk of volvulus compared to a gold standard based on fetal MRI. To describe normal meconium progression (ultrasound and MRI), prenatal anatomical variants of the fetal digestive tract, and interobserver agreement on prenatal ultrasound.

Official Title
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Diagnostic Performance of Antenatal Ultrasound in the Localization of Intestinal Structures Involved in Malrotation With a Higher-risk of Volvulus

Conditions
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Pregnancy Related

Intervention / Treatment
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* Other: Reference ultrasound examination


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Pregnant women over the age of 18 Good understanding of French Gestational age greater than or equal than 31 weeks Fetal MRI indication validated in multidisciplinary staff at weekly meetings of the Multidisciplinary Prenatal Diagnosis Center in Montpellier or Nimes Affiliation or beneficiary of a social security scheme Declaration of free and enlightened opposition Exclusion Criteria: Complex fetal abdominal malformations responsible for difficult interpretation of imaging: heterotaxis with asplenia or polysplenium, diaphragmatic hernia, omphalocele, gastroschisis, digestive pathology, abdominal tumor, bladder exstrophy or megavessia. Fetal chromosomal abnormality Request for termination of pregnancy validated by a Multidisciplinary Pre-natal Diagnosis Center

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Women with a pregnancy of at least 31 weeks<br>All pregnant women with a pregnancy of at least 31 weeks and having to perform a fetal MRI to identify a cerebral, pulmonary or renal fetal malformation, or due to a diagnostic doubt on ultrasound on an abnormality of these structures, will be proposed inclusion in the study. | Other: Reference ultrasound examination<br>* Use of antenatal ultrasound examination to visualize and position the intestinal structures involved in digestive malrotation at high risk of volvulus and comparison to fetal MRI results.<br>* Other names: Comparison of both results;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ultrasound localization of intestinal structure (mesenteric vessels, small bowel, gut) | The primary outcome will be ultrasound localization of intestinal structure (mesenteric vessels, small bowel, gut) | At the visit 1 of the subjects | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| normal meconium progression | Normal meconium progression will be described by the results of ultrasound examination and MRI | At the visit 1 of the subjects | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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malrotation, intestinal structures, mesenteric vessels