Substrate Oxidation Does Not Affect Short Term Food Intake in Healthy Boys and Men

Study Overview
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Brief Summary
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The purpose of this study is to investigate the effect of substrate oxidation, expressed by RER, on food intake regulation and net energy balance.

Detailed Description
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The relationship between substrate oxidation as measured by respiratory exchange ratio (RER) and food intake is undefined. This study is examining the effects of three modulators of substrate oxidation (RER), a glucose preload, exercise and age food intake regulation and net energy balance in normal-weight boys (9-12 y) and men (20-30 y). Subjects (15 boys, 15 men) were measured in random order with treatments of beverages of either water or glucose followed by either moderate exercise or rest for 40 min. Measures included RER via indirect calorimetry, energy expenditure, subjective appetite, food intake measured at an ad libitum pizza meal and net energy balance as the sum of the calories of the glucose preload + calories from the pizza lunch minus energy expended at exercise or rest.

Official Title
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Substrate Oxidation Does Not Affect Short Term Food Intake in Healthy Boys and Men.

Conditions
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Food Intake Regulation, Substrate Oxidation

Intervention / Treatment
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* Other: Glucose Preload and Exercise Intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Born at full term Men Age:20-29 years/BMI: 20-25 Boys Age 9-11/BMI percentile: 15th to 85th: Exclusion Criteria: Smokers Dieters Individuals with lactose intolerance, allergies to milk and dairy products Individuals with gastrointestinal problems Individuals with diabetes or other metabolic diseases Individuals scoring ≥ 11 on an Eating Habit Questionnaire

Ages Eligible for Study
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Minimum Age: 9 Years
Maximum Age: 29 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: water with resting condition<br> | |
| Experimental: glucose with resting condition<br> | Other: Glucose Preload and Exercise Intervention<br>* A glucose preload and exercise were administered to examine the modulate substrate oxidation<br>|
| Experimental: water with exercise condition<br> | Other: Glucose Preload and Exercise Intervention<br>* A glucose preload and exercise were administered to examine the modulate substrate oxidation<br>|
| Experimental: glucose with exercise condition<br> | Other: Glucose Preload and Exercise Intervention<br>* A glucose preload and exercise were administered to examine the modulate substrate oxidation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Food Intake | Energy intake from the ad libitum the pizza meal at 60 min was calculated based on the weight consumed and the compositional information provided by the manufacturer. | 60 - 90 min in the study | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Net Energy Balance | Will be calculated from the energy consumed by the glucose preload and the pizza meal minus energy expended at the exercise. | 0-90 min in the study | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Glucose, Exercise, Metabolic flexibility, Substrate Oxidation, Food intake