Influence of TMS on Attention Modulation

Study Overview
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Brief Summary
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The purpose of this study is to help understand how attention processes influence brain engagement during emotion and social cognition. The investigators also want to know if these processes are associated with drinking alcohol. Participation includes three study visits of about 2 hours each over approximately a month. The first visit involves a magnetic resonance imaging (MRI) scan and answering survey questions. Each of the next two visits will involve a session of transcranial magnetic stimulation (TMS, a non-invasive brain stimulation technique) followed by another MRI scan. People in the Auburn/Opelika area 19 or older are eligible to participate. People who drink alcohol and people who do not drink or don't drink very much are invited to participate.

Official Title
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A Combined Neurofeedback- TMS Intervention for Alcohol Use Disorder - Aim 2

Conditions
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Drinking, Alcohol

Intervention / Treatment
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* Device: TMS


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1. Age 18 or Older 2A. (Drinker Group): Reports consuming 4 [if female]/ 5 [if male] or more standard drinks on one occasion at least 2 times a month AND/OR reports consuming more than 7 [if female]/ 14 [if male] standard drinks per week on average 2B. (Healthy Volunteer Group): Reports consuming 4 [if female]/ 5 [if male] or more standard drinks on one occasion less than once a month AND reports consuming less than 7 [if female]/ 14 [if male] standard drinks per week on average Exclusion Criteria: MRI Contraindications Presence of metal in the body that would make having a 7T MRI unsafe (including facial tattoos) Claustrophobia, such that individual would be unable to stay in the MRI for up to 1 hr Hearing loss, including tinnitus, that might be made worse by MRI or TMS TMS Contraindications Has ever had a seizure, or has a family history of epilepsy Taking medications or substances that lower the seizure threshold* Implanted devices that are in the head or rely on physiological signals History of neurological disease, such as stroke or brain tumor Head injury with loss of consciousness greater than 30 minutes Actively withdrawing from alcohol Family history of schizophrenia or presence of psychotic symptoms

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: Participants will be randomly assigned to receive each arm in counterbalanced order (AB or BA).
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: TMS A<br>TMS administered over right frontal eye field at 10 Hz, 110% of MT, 60 x 5 sec trains, 25 sec ITI | Device: TMS<br>* TMS will be administered in a pattern that is either excitatory or inhibitory.<br>* Other names: Magventure MagPro;|
| Active Comparator: TMS B<br>TMS administered over right frontal eye field at 1 Hz, 110% of MT, 7 x 225 sec trains, 30 sec ITI | Device: TMS<br>* TMS will be administered in a pattern that is either excitatory or inhibitory.<br>* Other names: Magventure MagPro;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in attention switching | MRI Task- analysis of behavioral data | Baseline, immediately following TMS A, immediately following TMS B | 
| Change in sociomoral attention switching | MRI Task- analysis of behavioral data | Baseline, immediately following TMS A, immediately following TMS B | 
| Change in cue reactivity | MRI Task- analysis of behavioral data | Baseline, immediately following TMS A, immediately following TMS B | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in brain activity attention switching | MRI Task- analysis of imaging (fMRI) data | Baseline, immediately following TMS A, immediately following TMS B | 
| Change in brain activity during sociomoral attention switching | MRI Task- analysis of imaging (fMRI) data | Baseline, immediately following TMS A, immediately following TMS B | 
| Change in brain activity during cue reactivity | MRI Task- analysis of imaging (fMRI) data | Baseline, immediately following TMS A, immediately following TMS B | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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moral, MRI, frontal eye fields, moral cognition, alcohol, attention, TMS, binge drinking, emotion, social cognition