Multiparametric PET-MRI Integration for a New Approach to Tumor Heterogeneity in Non-Small Cell Lung Cancer (NSCLC): Pilot Study

Study Overview
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Brief Summary
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To estimate the intra and inter-operator reproducibility of multiparametric regional PET-MRI mapping in locally advanced and trace mestastatic non-small cell lung cancer (NSCLC).

Official Title
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Multiparametric PET-MRI Integration for a New Approach to Tumor Heterogeneity in Non-Small Cell Lung Cancer (NSCLC): Pilot Study

Conditions
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NSCLC

Intervention / Treatment
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* Diagnostic Test: PET-MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Locally advanced NSCLC (stages IIB, IIIA or IIIB of the TNM classification 7th edition) or trace metastatic stage IV (</=5 mestastasis, </= 3 organ reached) Exclusive therapeutic management by concomitant radio-chemotherapy administered in accordance with international recommendations (dual therapy with platinum salts) Signed consent Patients affiliated with the social security scheme or beneficiary of a similar scheme. Exclusion Criteria: Minor Pregnant / lactating woman Person deprived of liberty by judicial or administrative decision, adults who are the subject of a legal protection measure or unable to express their consent Previous cancer in the 2 years prior to registration Previousradiotherapy / thoracic surgery Patients under experimental treatment or for whom the administration of an experimental treatment is planned Claustrophobic patients Severe Renal Insufficiency (Clearance MDRD Cockroft <30ml / min) Uncontrolled diabetes, hyperglycemia> 1.8g / L Patient with metallic implants not compatible with MRI or any immovable implanted electronic medical device (eg pacemaker, neurostimulator, cochlear implants, etc.)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Patients with NSCLC<br>Characterization of tumor heterogeneity by multiparametric regional mapping PET-MRI. Patients will realize: a PET-MRI examination performed before the chemoradiotherapy treatment (so-called baseline PET-MRI) a PET-MRI examination performed midway through treatment (PET-MRI1 under treatment), after receiving 33 ± 4 Gy (approximately 2.5 months after the first PET-MRI). | Diagnostic Test: PET-MRI<br>* a PET-MRI examination performed before the chemoradiotherapy treatment (so-called baseline PET-MRI) a PET-MRI examination performed midway through treatment (PET-MRI1 under treatment), after receiving 33 ± 4 Gy (approximately 2.5 months after the first PET-MRI).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of intra and inter-operator reproducibility of multiparametric regional PET-MRI mapping performed before and under treatment. |  | Up to 24 months |