The Effect Of Glycemic Control On Malondialdehyde, Glutathione Peroxidase, Glutathione And Paraoxonase

Study Overview
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Brief Summary
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The aim of this study was to investigate the impact of glycemic control on clinical periodontal status, levels of malondialdehyde (MDA), glutathione peroxidase (GSH-Px), reduced glutathione (GSH) and paraoxonase (PON) activity in gingival crevicular fluid (GCF) and blood samples of type 2 diabetes mellitus (T2DM) patients with chronic periodontitis (CP).

Detailed Description
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Reactive oxygen species (ROS) are products of normal cellular metabolism and play beneficial role in physiological functions. Overproduction of ROS and/or deficiency of enzymatic or non-enzymatic antioxidants, termed as oxidative stress, is involved in many pathological conditions such as Diabetes mellitus (DM) and chronic periodontitis (CP). Several researches revealed that DM, with many determinants such as level of glycemic control, stands as a strong risk factor for periodontal diseases. On the other side, periodontal diseases induce an elevated chronic inflammatory state and exacerbated insulin resistance. In the present study, the investigators examined the effect of glycemic control level on clinical periodontal status, levels of MDA, GSH-Px, GSH and PON activity in gingival crevicular fluid and blood samples of CP patients with T2DM.

Official Title
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Malondialdehyde And Antioxidant Levels In Chronic Periodontitis Patients With Type 2 Diabetes Mellitus Under Different Stages Of Metabolic Control

Conditions
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Type 2 Diabetes Mellitus, Chronic Periodontitis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: to present T2DM diagnosis by an endocrinologist for at least the past 5 years diagnosis of CP was based on the clinical and radiographic criteria proposed by the 1999 World Workshop for Classification of Periodontal Diseases and Conditions Exclusion Criteria: pregnancy lactation current smoking or smoking within the past 2 years, periodontal therapy in the previous 6 months antibiotic and/or antimicrobial therapies in the previous 3 months existence of serious diabetic complications or any pathology such as haemoglobinopathy which would affect haemoglobin profile diagnosis of another major medical pathology, middle or upper-level obesity according to WHO classification current anti-hyperlipidemic therapy non-T2DM patients with abnormal values of glucose and lipid metabolism parameters, major medical pathology and family history of DM
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy<br> | |
| Chronic Periodontitis<br> | |
| Better Controlled T2DM<br> | |
| Poor Controlled T2DM<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HbA1c | Level of Metabolic Control | One Year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical Periodontal Status | Periodontal indices evaluating clinical periodontal health status | One Year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Diabetes mellitus, Chronic periodontitis, Malondialdehyde, Glutathione peroxidase, Paraoxonase