Quantitative Imaging and Proton Spectroscopy in Multiple Sclerosis

Study Overview
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Brief Summary
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The primary purpose of this study is to detect changes in the brain that may be associated with multiple sclerosis. Results will be compared to age matched controls. Investigators will assess lesions by measuring T2 and T1 enhanced lesion volumes and magnetization transfer ratio histogram parameters (MTRHP) in patients with relapsing-remitting and secondary-progressive disease. This data will be correlated to total brain parenchymal volume as well as identifying the effect of MS lesions on the gray and white matter, volumetric disability, including Kurtzke Expanded Disability Status Scale (EDSS) and a specific battery of neuropsychological tests. Quantitative analysis of whole brain N-acetylaspartate (WBNAA), a reproducible measure of viable neuron number, using 1H MRS and compare the results to age-matched controls over duration of 5 years.

Official Title
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Quantitative MR Imaging and Proton Spectroscopy in MS

Conditions
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Multiple Sclerosis

Intervention / Treatment
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* Device: Magnetic Resonance Imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with known MS diagnosis Age 7-110 years Males or females Exclusion Criteria: Medically unstable Artificial implants in the body Pregnant Normal Controls

Ages Eligible for Study
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Minimum Age: 7 Years
Maximum Age: 110 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: MS Patients<br>All subjects enrolled in this study will undergo MRI studies. A computerized neuropsychological battery of tests will be administered. | Device: Magnetic Resonance Imaging<br>* Magnetic Resonance Imaging EDSS<br>|
| Other: Healthy Patients<br>Patients enrolled in this study will undergo MRI studies. A computerized neuropsychological battery of tests will be administered. | Device: Magnetic Resonance Imaging<br>* Magnetic Resonance Imaging EDSS<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assess the MS lesions using Magnetization transfer ratio histogram parameters and compare it to total brain parenchymal volume | 1) Lesions will be assessed by measuring T2 and T1 enhanced lesion volumes and magnetization transfer ratio histogram parameters (MTRHP) in patients with relapsing-remitting and secondary-progressive disease. This data will be correlated to total brain parenchymal volume as well as identifying the effect of MS lesions on the gray and white matter, volumetric disability, including Kurtzke Expanded Disability Status Scale (EDSS) and a specific battery of neuropsychological tests | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quantitative analysis of whole brain N-acetylaspartate (WBNAA) | Quantitative analysis of whole brain N-acetylaspartate (WBNAA), a reproducible measure of viable neuron number, using 1H MRS and compare the results to age-matched controls over duration of 5 years | 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Quantitative Imaging of Multiple Sclerosis