linjc16/ctgov huggingface dataset:
Oncogenous HPV DNA Integration (Intégration De l'ADN Des HPV Oncogènes)

Study Overview
=================
Brief Summary
-----------------
High-risk human papillomavirus (HR-HPV) are involved in cervical cancer development. Integration of HR-HPV DNA in cellular genomes is considered as a major event in the cervical cancer development. The aim of this study is to validate the integration of the HPV-HR as an appropriate biomarker of the severity of precancerous lesions and progression of cervical lesions towards cervical cancer. HR-HPV integration status will be analyzed by Molecular Combing technology, which allows direct and high-resolution visualization of the integration of high-risk HPV genomes.

Official Title
-----------------
Association Between High-risk HPV Genome Integration Detected by Molecular Combing and Cervical Lesions Severity and/or Evolution

Conditions
-----------------
Abnormal Cytology

Intervention / Treatment
-----------------
* Other: all patients included in IDAHO study


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: women aged from 25 to 65 years consulting in a gynecological-obstetrical service of one of the investigator center for a colposcopy reflex after an abnormal cytology dating of less than 6 months and more than 1 month signature of the informed consent affiliated to Social Security Exclusion Criteria: women vaccinated against HPV women who received a treatment for a cervical pathology followed by a normal women with a known positive HIV test women suffering from a chronic pathology that generate immunosuppression Women currently treated with immunosuppressors Women treated with corticoids currently or dating of less than 6 months protected by law pregnant

Ages Eligible for Study
-----------------
Minimum Age: 25 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: arm 1<br>all patients included in IDAHO study | Other: all patients included in IDAHO study<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| presence of high-risk papillomavirus in the analysis of cervical smear |  | during 36 months after inclusion | 
| integration of genome of high-risk papillomavirus detected in cervical smear according molecular combing |  | during 36 months after inclusion | 
| presence and severity of cervical lesion according to results of cervical smear, colonoscopy and histological analysis |  | during 36 months after inclusion | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
High-risk human papillomavirus, Integration of HR-HPV DNA, biomarker of severity, biomarker of evolution
Motivational and Cognitive Intervention for College Drinkers

Study Overview
=================
Brief Summary
-----------------
In the proposed project the investigators will develop and test a novel brief intervention targeting college students who drink heavily to cope with anxiety and depression, a behavior that increases risk for the development of alcohol dependence.

Official Title
-----------------
Motivational and Cognitive Intervention for College Drinkers

Conditions
-----------------
Alcohol Consumption, Anxiety, Depression

Intervention / Treatment
-----------------
* Behavioral: Motivational and Cognitive Intervention for Drinkers (MCID)
* Behavioral: Brief Motivational Intervention (BMI)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - 1. At least 1 heavy drinking episode (4 or more drinks for women; 5 or more drinks for men). 2. Sub-clinical anxiety or depression 3. Occasional to frequent drinking related problems Exclusion Criteria: 1. Clinical Axis I diagnosis 2. Current suicidal ideation, pregnancy, major medical illness, severe alcohol dependence, current hallucinations

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 25 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: MCID<br> | Behavioral: Motivational and Cognitive Intervention for Drinkers (MCID)<br>* Integrate social anxiety/ depression and drinking intervention<br>|
| Experimental: BMI<br> | Behavioral: Brief Motivational Intervention (BMI)<br>* Integrate drinking intervention<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Alcohol Consumption and Drinking-Related Negative Consequences |  | Pre-Treatment, 2-month follow-up, 4-month follow-up, 6-month follow-up | 
| Anxiety |  | Pre-Treatment, 2-month follow-up, 4-month follow-up, 6-month follow-up | 
| Depression |  | Pre-Treatment, 2-month follow-up, 4-month follow-up, 6-month follow-up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cost efficacy data |  | 2-3 months post completion | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Alcohol Consumption, Social Anxiety, Depression, Brief Intervention, Motivational Interviewing, Cognitive Behavioral Therapy, Sub-Clinical Social Anxiety, Sub-Clinical Depression
Framingham Cycle V Offspring-Spouse Nutrition Studies

Study Overview
=================
Brief Summary
-----------------
To examine the associations between diet, nutrition and coronary heart disease (CHD) incidence over seven years using the Cycle V Framingham Offspring/Spouse examination ; to examine the cross-sectional associations between dietary variables and major cardiovascular disease risk factors, to examine changes in dietary behaviors and their determinants over seven years; and to characterize the influences of dietary behavior changes on risk factor status between 1984-88 and 1991-94.

Detailed Description
-----------------
DESIGN NARRATIVE: The data collection efforts and cross-sectional analyses were carried out among approximately 3800 males and females during the scheduled 1991-1994 Cycle V Framingham Offspring/Spouse study. The secular trend and longitudinal analyses also included data that were collected during the Cycle III Offspring/Spouse studies in 1984-88. Of particular interest were dietary variables which play a major role in serum total cholesterol and lipoprotein regulation. Additional dietary variables which were associated with major cardiovascular risk factors ((elevated) blood pressure, glucose (in)tolerance, (excess) body weight or physical (in)activity, and smoking) or that may predict CHD endpoints were included in the analyses. The potential confounding effects or interactions between dietary and risk factor variables were considered. Separate analyses were carried out in males and females. The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System (PRS) record.

Conditions
-----------------
Atherosclerosis, Cardiovascular Diseases, Coronary Disease, Heart Diseases, Hypertension, Obesity, Diabetes Mellitus

Participation Criteria
=================
Eligibility Criteria
-----------------
No eligibility criteria

Ages Eligible for Study
-----------------
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Persistent Pain After Breast Cancer Treatment With Docetaxel

Study Overview
=================
Brief Summary
-----------------
Breast cancer treatment is for many patients followed by sequelae, such as persistent pain, sensory disturbances, lymphedema and reduced physical function. These undesired consequences of the treatment are a major clinical problem, with persistent pain affecting 25-60%, sensory disturbances 20-80%, lymphedema 2-86% and reduced physical function 13-28% of patients. Development of persistent pain after breast cancer treatment, involves a complex pathophysiology that involves pre-, intra- and postoperative factors. Several risk factors for the development of persistent pain after breast cancer treatment have been identified; young age, psychosocial factors, surgical procedure and radiation therapy. Neurotoxicity is a well know attribute of many chemotherapeutic agents, such as taxanes. The purpose of this nationwide study is to retrospectively examine a cohort of breast cancer patients treated with docetaxel, to clarify if docetaxel may influence the prevalence and intensity of persistent pain and other sequelae.

Official Title
-----------------
Persistent Pain After Breast Cancer Treatment With Docetaxel

Conditions
-----------------
Breast Neoplasms, Pain, Postoperative, Neuralgia, Lymphedema

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Treated for primary breast cancer in Denmark 2007-2008 Age between 18-80 years No recurrent cancer Female Exclusion Criteria: Previous breast surgery same side (including plastic and reconstructive surgery) Bilateral breast surgery Recurrent cancer or metastatic cancer

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
Female

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients treated with docetaxel<br>Patients treated according to the DBCG 07 protocol, that have received docetaxel as part of the adjuvant treatment. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Docetaxel as a risk factor for development of persistent pain |  | Between 2-3 years post surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of persistent pain, sensory disturbances, lymphedema and functional limitations |  | Between 2-3 years post surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Persistent postsurgical pain, breast cancer, postmastectomy pain syndrome, neuropathic pain
Association of Carotid Arterial Circumferential Strain With Left Ventricular Function and Hemodynamic Compromise During Off-pump Coronary Artery Bypass Surgery

Study Overview
=================
Brief Summary
-----------------
This study is aimed to evaluate the association of common carotid artery circumferential strain with the echocardiographic parameters of left ventricular function and the degree of actual hemodynamic deterioration in patients undergoing multi-vessel off-pump coronary artery bypass with preserved left ventricular ejection fraction.

Conditions
-----------------
Three Vessel Coronary Artery Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: three vessel coronary artery disease sinus rhythm Exclusion Criteria: New York Heart Association functional class ≥3 known pulmonary hypertension known valvular heart disease serum creatinine ≥2.0 mg/dL myocardial infarction within 1 week before the surgery history of cerebral or peripheral arterial occlusive disease

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| CAOD group<br>Single arm study group | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| TTE parameters | TTE parameters: left ventricular ejection fraction, left atrial volume index, left ventricular mass, Sm, Em, E/Em | 1 day before the surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change of intraoperative hemodynamic variables | TTE parameters: left ventricular ejection fraction, left atrial volume index, left ventricular mass, Sm, Em, E/Em Carotid circumferential strain : Storage of transverse image of the right CCA at approximately 1cm proximal to the bifurcation, manual trace of luminal-intimal border and automatic tracking by frame-to-frame movement of ultrasound reflections (speckles) Hemodynamic variables: cardiac index and mixed venous oxygen saturation obtained from the pulmonary artery catheter and cardiac output monitoring devices | from after induction of anesthesia, left circumflex artery grafting, and to sternum closure | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
off-pump coronary artery bypass surgery, common carotid artery, speckle tracking analysis, peak strain
Exercise During the Allogeneic Stem Cell Transplantation

Study Overview
=================
Brief Summary
-----------------
The study will evaluate the effects of a structured endurance exercise program on the physical performance, the mood and the complications of patients with hematological malignancies undergoing a high-dose chemotherapy followed by an allogeneic peripheral blood stem cell transplantation.

Official Title
-----------------
Exercise During the Allogeneic Stem Cell Transplantation

Conditions
-----------------
Fatigue, Allogeneic Stem Cell Transplantation

Intervention / Treatment
-----------------
* Other: Supervised exercise
* Other: Exercise Instruction


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Neoplastic malignancy Allogeneic peripheral stem cell transplantation Proficiency in German Exclusion Criteria: Cardiorespiratory, metabolical, osteoarticular or immunological disorders which can be aggravated by exercise Pathological stress-ECG at admission

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Supervised exercise<br> | Other: Supervised exercise<br>* The patients will carry out a daily exercise program consisting of walking on a treadmill for 30 minutes at an intensity of 80% of the maximum heart rate. The patients will be supervised by medical personnel.<br>|
| Active Comparator: Control group<br> | Other: Exercise Instruction<br>* The patients will receive instructions about exercise and will have access to a bike ergometer to work out. However, they will not receive daily supervision or participate in a structured exercise program.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| VO2max |  | At recruitment and after 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complications |  | 4 weeks | 
| Mood |  | At recruitment and after 4 weeks | 
| Requirement for blood and platelets transfusions |  | 4 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Exercise, sport, Allogeneic blood stem cell transplantation, Blood stem cell transplantation, Fatigue, Cancer, Physical performance, Mood, Complications
Breast Tumor Oxygenation During Exercise

Study Overview
=================
Brief Summary
-----------------
In the field of cancer treatment, it is generally accepted that the enhancement of oxygen delivery to tumors can augment the effect of anti-cancer therapies. In the case of chemotherapy, this enhancement might lead to a larger amount of a given dose of treatment reaching the tumor and having an effect.

Detailed Description
-----------------
While the benefits of exercise on overall health are widely documented, little is known about how exercise affects the progression or treatment of malignant neoplasms. Tumors have a complex vascular network which is likely affected by the global changes in hemodynamics and perfusion that occur during moderate exercise. Increased tumor oxygenation is clinically relevant as it may counteract the hypoxic tumor environment which is known to contribute to resistance to chemo- and radiation therapies, angiogenesis, invasiveness and metastasis, genomic instability, and resistance to cell death. The researcher can use noninvasive optical imaging technology called diffuse optical spectroscopy to safely and non-invasively quantify the dynamics of blood flow and metabolism in tumors and normal tissue of subjects undergoing supervised cycling exercise. The researcher can determine that exercise will measurably increase tumor oxygenation, and that this effect will be proportional to the intensity and/or duration of the exercise performed.

Official Title
-----------------
Breast Tumor Oxygenation During Exercise

Conditions
-----------------
Breast Tumor

Intervention / Treatment
-----------------
* Device: diffuse optical spectroscopy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Tumor group, female, Greater than 21 years of age but less than 70 years of age, Current diagnosis of breast cancer stage 0 - IV or radiologically suspicious for breast cancer BI-RADS score 4 or 5. Control group,Female, Greater than 21 years of age but less than 70 years of age, Not currently diagnosed with breast cancer Exclusion Criteria: Under 21 years of age, Pregnant or breastfeeding, Contraindications for moderate exercise, history of heart, pulmonary, or musculoskeletal disease; physician instructions to restrict physical activity.

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: diffuse optical spectroscopy|diffuse optical spectroscopy|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measure breast tumor oxygenation |  | up to 12 weeks |
Effectiveness of Routine Sterile Gloving in Blood Culture

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine whether routine sterile gloving can lower contamination rates in blood culture.

Detailed Description
-----------------
Because contamination during sampling for blood culture may interfere in interpreting the results of blood culture, lowering the contamination rates in blood culture is very important. According to current guideline, routine sterile gloving is not recommended. We hypothesized that routine sterile gloving can lower contamination rates in blood culture.

Official Title
-----------------
Influence of Routine Sterile Gloving on Contamination Rates in Blood Culture

Conditions
-----------------
Bacteremia

Intervention / Treatment
-----------------
* Behavioral: Routine sterile gloving


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The patients in whom Blood culture is medically needed Exclusion Criteria: Blood sample is obtained through central venous catheter or arterial line No consent to this study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: conventional gloving<br> | |
| Experimental: routine sterile gloving<br> | Behavioral: Routine sterile gloving<br>* routinely new sterile gloving just before sampling<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| contamination rate in blood culture |  | at the time of identification of organisms | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
bacteremia, blood culture, contamination
Prospective, Multi-Center Adult Spinal Deformity Outcomes Database Registry

Study Overview
=================
Brief Summary
-----------------
The clinical, radiographic, and HRQL outcomes will be compared in operative and nonoperative adult spinal deformity patients.

Official Title
-----------------
Prospective, Multi-Center Adult Spinal Deformity Outcomes Database Registry

Conditions
-----------------
Spinal Deformity

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of adult degenerative or idiopathic scoliosis with a curvature of the spine measuring greater than or equal to 20 degrees Sagittal Vertical Axis (SVA) > 5cm Pelvic Tilt > 25 degrees Thoracic kyphosis > 60 degrees Age 18 or greater at the time of enrollment. Exclusion Criteria: Diagnosis of scoliosis other than degenerative or idiopathic (i.e. paralytic/neuromuscular, congenital) Age <18 yrs at time of surgery or initial consultation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Operative<br>Diagnosis of adult degenerative or idiopathic scoliosis with a curvature of the spine measuring greater than or equal to 20 degrees requiring surgery. | |
| Nonoperative<br>Diagnosis of adult degenerative or idiopathic scoliosis with a curvature of the spine measuring greater than or equal to 20 degrees not requiring surgery. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Radiographic | Coronal and Sagittal views of the spine | initial visit, 1 year, 2 years, 3-5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical outcomes | physical examination/pain scale | initial visit, 1 year, 2 years, 3-5 years | 
| Health related quality of life | Oswestry, SRS22r, SF-36, LSDI, EQ5D3L, NDI DRAM (optional) | initial visit, 1 year, 2 years, 3-5 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
scoliosis, kyphosis, treatment outcomes, spinal deformity