The Differences of Muscle Activity Between Patients With COPD and Healthy Adults

Study Overview
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Brief Summary
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The purpose of this study attempts to investigate the differences and relationships of respiratory parameters, muscle activity, and dyspnea during ADL between patients with COPD and age-matched healthy participants.

Official Title
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Comparing Activity of Accessory Inspiratory Muscles and Upper Limb Muscles During Performing Activities of Daily Living Between Patients With Chronic Obstructive Pulmonary Disease and Healthy Adults

Conditions
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Chronic Obstructive Pulmonary Disease

Intervention / Treatment
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* Other: no intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 40 years or older With the clinical diagnosis of COPD Exclusion Criteria: With the clinical diagnosis of asthma or cancer With cardiovascular, musculoskeletal and neurological diseases limiting physical activities in daily life In the unstable medical state MMSE under 25 Barthel index score under 61

Ages Eligible for Study
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Minimum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COPD group<br>No intervention 40 years or older, clinical diagnosis of COPD (Global Initiative for Chronic Obstructive Lung Disease stages I to IV) | Other: no intervention<br>* no intervention in this study<br>|
| healthy group<br>40 years or older, not with the clinical diagnosis of COPD | Other: no intervention<br>* no intervention in this study<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiopulmonary exercise testing device | The machine analyze the breath of participants including oxygen consumption and minute ventilation volume. Oxygen consumption is reported in mL/min and minute ventilation volume is reported in L/min. | baseline | 
| Surface electromyography device | The surface EMG is performed to assess the maximum voluntary contraction and muscle activity of upper limb muscles and accessory inspiratory muscles during performing simulated ADL tasks. The maximal voluntary contraction (MVC) is used as the reference level of muscle activity to normalize the EMG data of performing simulated ADL tasks. The muscle activity is reported in percentage. | baseline | 
| The clinical Chronic Obstructive Pulmonary Disease questionnaire | This is a self-reported questionnaire to measure the impact of COPD on participants' health status. The rating scores is a 7-point scale (0=no limitation, 6=totally limited).Higher scores mean the more severe impact of COPD on participants' daily living. | baseline | 
| Modified Borg Scale | This is a self-reported scale to measure how much participants perceive dyspnea. The range from 0 which means no difficulty to breathe to 10 which means with maximal difficulty to breathe. | baseline | 
| Modified Medical Research Council | This is a five-point scale to assess the severity of breathlessness. | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| EQ-5D questionnaire | This is a self-reported questionnaire for measuring generic health status | baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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activities of daily living, accessory inspiratory muscles, oxygen consumption, minute ventilation volume