High-density EEG in Neurological Disorders

Study Overview
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Brief Summary
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The purpose of the study is to use a new method of high-density electroencephalogram (HD-EEG) recording to map brain areas important for movement, sensation, language, emotion, and cognition.

Detailed Description
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This study will measure brain waves using high-density EEG. Participants will be asked wear a cap with electrodes attached to it. During the recording, participants may be asked to rest, sleep, or complete a task. The tasks involve viewing pictures, answering questions, speaking, or moving an arm or leg. Recordings generally last between 60-120 minutes.*

Official Title
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High-density EEG in Neurological Disorders

Conditions
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Epilepsy, Tumor, Healthy

Intervention / Treatment
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* Diagnostic Test: High-density electroencephalogram (HD-EEG)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Able to perform the tasks Able to give own consent Exclusion Criteria: Any neurologic or psychiatric diagnosis such as stroke, tumor, or psychosis judged to interfere with high-density EEG.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: High-density EEG localization in epilepsy<br>High-density EEG will be used for brain localization in epilepsy patients | Diagnostic Test: High-density electroencephalogram (HD-EEG)<br>* This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.<br>|
| Active Comparator: High-density EEG localization in healthy controls<br>High-density EEG will be used for brain localization in healthy controls | Diagnostic Test: High-density electroencephalogram (HD-EEG)<br>* This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.<br>|
| Experimental: High-density EEG localization in tumor patients<br>High-density EEG will be used for brain localization in tumor patients | Diagnostic Test: High-density electroencephalogram (HD-EEG)<br>* This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.<br>|
| Experimental: High-density EEG localization in peripheral nerve patients<br>High-density EEG will be used for brain localization in patients with peripheral nerve dysfunction | Diagnostic Test: High-density electroencephalogram (HD-EEG)<br>* This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.<br>|
| Experimental: High-density EEG localization in stroke patients<br>High-density EEG will be used for brain localization in patients who have recently experienced a stroke | Diagnostic Test: High-density electroencephalogram (HD-EEG)<br>* This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Localize brain functions in patients and healthy controls | Localize brain functions using high-density EEG recordings | 60 - 90 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Localize brain areas involved in language | Localize brain areas involved in language using high-density EEG recordings | 60 - 90 minutes | 
| Localize brain areas involved in movement | Localize brain areas involved in movement using high-density EEG recordings | 60 - 90 minutes | 
| Localize brain areas involved in sensation | Localize brain areas involved in sensation using high-density EEG recordings | 60 - 90 minutes | 
| Localize brain areas involved in emotion | Localize brain areas involved in emotion using high-density EEG recordings | 60 - 90 minutes | 
| Localize brain areas involved in memory | Localize brain areas involved in memory using high-density EEG recordings | 60 - 90 minutes | 
| Localize brain areas associated with lesions | Localize brain areas associated with lesions using high-density EEG recordings | 60 - 90 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Electroencephalogram (EEG), Epilepsy, Lesion, Brain, Language, Movement, Sensation, Mapping, Dense-array EEG, High-density EEG, HD-EEG, stroke, Electrical Impedance Tomography