linjc16/ctgov huggingface dataset:
Time - Related Cuff Pressure and Volume of the Laryngeal Tube With the Use of Nitrous Oxide

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to investigate the time-related intracuff pressure and volume change (which reflects the pharyngeal pressure) of the LT during anesthesia with N2O.

Detailed Description
-----------------
Background : The laryngeal tube airway (LT) is an extraglottic airway device with a proximal and distal conical cuff designed to secure a patient's airway during either spontaneous breathing or controlled ventilation. Application of this device with the use of N2O may be related to the ischemic change of the oropharyngeal mucosa. The objective of this study was to investigate the time-related intracuff pressure and volume change (which reflects the pharyngeal pressure) of the LT during anesthesia with N2O. Methods : Seventy-five patients were studied with the use of LT size 4. N2O (66%) and isoflurane were used to maintain anesthesia. Initial intracuff pressure and volume were recorded for airway sealing during ventilation. Time-course changes of the intracuff pressure followed by recording every 10 min. If the intracuff pressure reached 100 cmH2O, the cuff was deflated to the initial intracuff pressure and the volume of deflated air and postoperative airway complications were recorded.

Official Title
-----------------
Time - Related Cuff Pressure and Volume of the Laryngeal Tube With the Use of Nitrous Oxide

Conditions
-----------------
Adult Disease

Intervention / Treatment
-----------------
* Device: laryngeal tube (VBM Medizintechnik)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: American Society of Anesthesiologist physical status I or II Undergoing elective orthopedic surgery and surgery of breast under general anesthesia with an expected duration of 60 min or more Exclusion Criteria: Height was < 155 or >180 cm (for the use of laryngeal tube size 4) Body mass index ≥35 kg/m2 Preexisting laryngotracheal disease Risk of pulmonary aspiration of gastric contents.

Ages Eligible for Study
-----------------
Minimum Age: 15 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| intracuff pressure N2O<br>measured intracuff pressure of LT with N2o during operative period | Device: laryngeal tube (VBM Medizintechnik)<br>* laryngeal tube number 4<br>* Other names: The laryngeal tube (VBM Medizintechnik, Sulz, Germany);|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| intracuff pressure | measured intracuff pressure of LT with N2O during intraoperative period | 1-4 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
intracuff pressure, laryngeal tube, nitrous oxide
Effects of Aerobic Training on Exercise Capacity in Patients With Cirrhosis

Study Overview
=================
Brief Summary
-----------------
Cirrhosis is associated with a reduction in muscle mass and exercise capacity. This has an impact or morbidity and mortality. Regular aerobic exercise training is a proven effective therapy to improve exercise capacity in healthy and clinical populations. the effect of this training has not yet been evaluated in cirrhosis. The safety of this intervention also requires further study. Using a randomized controlled design, the investigators aim to conduct a pilot study evaluating the safety and efficacy of eight weeks of aerobic exercise training on aerobic capacity.

Official Title
-----------------
Aerobic Training in Patients With Cirrhosis

Conditions
-----------------
Cirrhosis

Intervention / Treatment
-----------------
* Behavioral: Aerobic exercise
* Other: Usual Care


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age ≥18 and ≤70 years Cirrhosis Child Pugh class A or B If required, primary or secondary variceal prophylaxis in place Exclusion Criteria: Post-liver transplantation Hepatocellular carcinoma Active non-Hepatocellular carcinoma malignancy Significant cardiac disease - ejection fraction <60% or known coronary artery disease Oxygen saturation at rest <95% Known myopathy Hemoglobin (<100 g/L) Chronic renal failure on dialysis Physical impairment making it impossible to ride an exercise bike or treadmill Orthopedic abnormality preventing exercise training HIV infection Patient unwilling to consent to study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Aerobic exercise<br>Supervised aerobic training 3 times per week for 8 weeks (30-60 minute sessions) | Behavioral: Aerobic exercise<br>* Aerobic exercise for 8 weeks (3 times per week, 30-60 minutes each session)<br>|
| Placebo Comparator: Usual care group<br>These patients will continue with their normal daily activity and will not be provided with supervised aerobic exercise training during the study period. | Other: Usual Care<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in peak exercise pulmonary oxygen uptake (peak VO2) |  | Baseline (day 1) and Study End (8 weeks) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in muscle mass as measured by thigh ultrasound |  | Baseline (day 1) and study end (8 weeks) | 
| Change in Quality of Life - Chronic Liver Disease Questionnaire |  | Baseline (day 1) and Study End (8 weeks) |
Implementation Research of New Dengue Vector Control Tools

Study Overview
=================
Brief Summary
-----------------
This project will provide new insights concerning how to reduce dengue transmission by means of cost-effective and sustainable implementation strategies of vector control methods. The research will assess key strategies which deliver new vector control tools with respect to their cost-effectiveness, acceptability and sustainability in contrasting environments.

Official Title
-----------------
Implementation Research of New Dengue Vector Control Tools

Conditions
-----------------
DENGUE

Intervention / Treatment
-----------------
* Other: Insecticide treated curtains and insecticide treated covers


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: No patients, but communities were included, with as inclusion criteria: neighborhoods of Lam Chabang, Thailand and Valera and San Rafael de Carvajal, Venezuela after obtaining community approval Exclusion Criteria: Neighborhoods without community approval
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: VM<br>implementation of new vector control tools (insecticide treated curtains and jar covers) through the existing routine vector control programme | Other: Insecticide treated curtains and insecticide treated covers<br>* The study is comparing the introduction of two new vector control tools (insecticide treated curtains and insecticide treated covers) through two different distribution strategies. These tools are curently not in use in the routine programmes of the concerned countries.<br>|
| Experimental: PM<br>implementation of new vector control tools (insecticide treated covers and curtains) through partnerships | Other: Insecticide treated curtains and insecticide treated covers<br>* The study is comparing the introduction of two new vector control tools (insecticide treated curtains and insecticide treated covers) through two different distribution strategies. These tools are curently not in use in the routine programmes of the concerned countries.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Aedes aegypti entomological indices |  | every 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| uptake and acceptance of tools |  | 6 and 18 months after distribution | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
IMPLEMENTATION RESEARCH, AEDES, VECTOR CONTROL
Gut Microbiota as a Therapeutic Target for CVD

Study Overview
=================
Brief Summary
-----------------
Background: The Mediterranean Diet (MD) is considered an healthy diet useful in the prevention of cardiovascular disease (CVD). High quality extra virgin olive oil (HQ-EVOO, [1]), an essential component of this diet, exerts a protective effect against CVD. Moreover, the gut microbiota (GM) has recently been recognized as a key factor in driving metabolic activities and involved in the stimulation of host immunity [2]. In particular, Lactic Acid Bacteria (LAB) and their probio-active cellular substances produce beneficial effects in the gastrointestinal tract, thus representing important assets in pathological conditions such as obesity and CVD [3,4]. Objective: The purpose of this study is to demonstrate that 3 months of treatment (MD with 40g/die HQ-EVOO) in 36 subjects (cases: overweight/obese vs controls: normal weight) may change their GM and inflammatory panel.

Official Title
-----------------
Gut Microbiota as a Novel Therapeutic Target for Prevention of Cardiovascular Diseases in Obese and Non-obese Adult Subjects

Conditions
-----------------
Obesity

Intervention / Treatment
-----------------
* Other: High quality extra virgin olive oil


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: normal weight subjects (M and F) with Body Mass Index (BMI) between 18.5 and 24.9 Kg/m2 following MD; overweight/obese subjects with a BMI ≥ 25 Kg/m2, not necessarily following MD. Exclusion Criteria: eating disorders; recent or ongoing antibiotic therapy.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Cases<br> | Other: High quality extra virgin olive oil<br>* Cases and controls were given 40 g/die high quality extra virgin olive oil<br>|
| Other: Controls<br> | Other: High quality extra virgin olive oil<br>* Cases and controls were given 40 g/die high quality extra virgin olive oil<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| anti-inflammatory cytokines |  | Time 0 (T0) | 
| changes in anti-inflammatory cytokines |  | after 3 months from T0 (T1) |
Delayed Colorectal Cancer Care During Coronavirus Disease (COVID-19) Pandemic (DECOR-19)

Study Overview
=================
Brief Summary
-----------------
To understand and analyse the global impact of COVID-19 on outpatient services, inpatient care, elective surgery, and perioperative colorectal cancer care, a DElayed COloRectal cancer surgery (DECOR-19) survey was conducted in collaboration with numerous international colorectal societies with the objective of obtaining several learning points from the impact of the COVID-19 outbreak on our colorectal cancer patients which will assist us in the ongoing management of our colorectal cancer patients and to provide us safe oncological pathways for future outbreaks.

Official Title
-----------------
DElayed COloRectal Cancer Care During Coronavirus Disease (COVID-19) Pandemic (DECOR-19)

Conditions
-----------------
Colo-rectal Cancer, Colon Cancer, Rectal Cancer, Oncology, Surgery

Intervention / Treatment
-----------------
* Other: Survey


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Members of renowned scientific societies with an interest in coloproctology Exclusion Criteria: None
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Survey|International E-survey|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Predictive power of respondents' and hospitals' demographics on delaying colorectal cancer care across 6 geographical regions | Respondents' and hospitals' demographics include: gender, country of origin, type of hospital (i.e. academic or not), type of unit (general surgery vs. colorectal), no. hospital beds, no. yearly surgeries for colon and rectal cancer, hospital preparedness to the emergency (i.e. fully or partially dedicated or not involved in COVID-19 care), readily availability of external facilities for colorectal cancer surgery, cancer care coordinator, personal protective equipment, status of elective surgery, no. elective colorectal cancer patients needing urgent surgery, any change in the original management plan, no. colorectal cancer patients refusing surgery or being COVID-19 + on surgery or becoming COVID-19 + post-operatively, no. staff members quarantined or relocated in COVID-19 units, MDT meeting suspension, any delay in endoscopy, radiology, oncology, surgery, histopathology. | 20 days |
Study of a Novel Interposition Supraciliary Implant in Patients With Open Angle Glaucoma

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the safety and effectiveness of a novel interposition supraciliary implant as a stand-alone therapy for lowering intraocular pressure (IOP) in patients with primary open angle glaucoma (POAG) who have failed at least one class of topical medical therapy

Detailed Description
-----------------
68 patients will be included in this 5 years interventional study. All patients shall be indicated for glaucoma surgery alone (not combined with cataract), and will undergo incisional glaucoma therapy, including a novel simplified surgical technique allowing placement of an interposition supraciliary permanent device. Several patient data like IOP, visual capacity or associated pharmacological treatments will be recorded pre and post-operatively all along the follow-up. Purpose is to ensure device safety, and verify IOP and associated pharmacological treatment reduction after surgery, and evolution along follow-up.

Official Title
-----------------
Non Randomised Multi-centered Study to Evaluate Safety and Efficacy of a Novel Interposition Supraciliary Implant in Glaucoma Patients Refractory to Topical Therapy

Conditions
-----------------
Glaucoma, Open-Angle

Intervention / Treatment
-----------------
* Device: Interposition supraciliary implant


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of POAG Schafer 3 or 4 Medicated IOP ≥ 21 Exclusion Criteria: Inflammatory, congenital, traumatic, neovascular, ICE syndrome, angle closure and Schaffer 1 and 2 glaucoma Non surgical interventional treatment (cyclophotocoagulation, ultrasounds, …) Medical treatment having intraocular hypotensive effect

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Interposition supraciliary implant<br>Any patients corresponding to inclusion / exclusion criteria | Device: Interposition supraciliary implant<br>* Surgical placement of an interposition supraciliary implant in the supraciliary space<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assess post-op IOP reduction | Proportion of Eyes With Intraocular Pressure (IOP) Reduction of ≥ 20% | 6 months | 
| Assess post-op IOP clinical success | Proportion of Eyes With Intraocular Pressure (IOP) < 21 mmHg | 6 months |
Parent Intervention to Reduce Binge Drinking

Study Overview
=================
Brief Summary
-----------------
Parent and peer interventions to reduce student drinking

Detailed Description
-----------------
Parent and peer interventions to reduce student drinking: Efficacy; Mediation: Moderation

Official Title
-----------------
Parent Intervention to Reduce Binge Drinking

Conditions
-----------------
Alcohol Consumption

Intervention / Treatment
-----------------
* Behavioral: Parent Handbook and Peer Basics


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: varsity athlete in high school Exclusion Criteria: not a varsity athlete in high school

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 25 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: parent handbook<br>parent handbook | Behavioral: Parent Handbook and Peer Basics<br>* Parent and Peer delivered interventions<br>* Other names: Peer Delivered BASICS;|
| Experimental: peer basics<br>peer delivered basics | Behavioral: Parent Handbook and Peer Basics<br>* Parent and Peer delivered interventions<br>* Other names: Peer Delivered BASICS;|
| Experimental: parent handbook and peer basics<br>parent handbook and peer basics | Behavioral: Parent Handbook and Peer Basics<br>* Parent and Peer delivered interventions<br>* Other names: Peer Delivered BASICS;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| heavy episodic drinking | typical daily drinking | 6 months post baseline | 
| heavy episodic drinking | typical daily drinking | 9 months post baseline | 
| heavy episodic peak drinking | peak number of drinks in one night | 6 months post baseline | 
| heavy episodic peak drinking | peak number of drinks in one night | 9 months post baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| drinking consequences | frequency of blackouts, hangovers, vomiting, fights, unplanned sex, trouble with police, poor academic performance as measured by the rapi; yaapst (standard instruments used in all college alcohol prevention trials) | 9 months post baseline | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
parents, peer, basics, college student drinking
COVID-19 Ad Intervention

Study Overview
=================
Brief Summary
-----------------
This study will provide advertisements to (de-identified) participants and track (de-identified) movement patterns to learn whether the ads increase adherence to stay-at-home orders.

Official Title
-----------------
COVID-19 Ad Intervention for Social Distancing

Conditions
-----------------
Social Distance

Intervention / Treatment
-----------------
* Behavioral: Social Distancing Advertisements


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years of age or older (as identified by company running advertisements); recent visit to a non-essential location; agreed to terms and conditions of websites allowing advertisements Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention Group<br>Advertisements will be sent to participants to attempt to increase adherence to stay-at-home orders and social distancing. There are 3 types of advertisements. This will occur for 7 days. | Behavioral: Social Distancing Advertisements<br>* Participants will receive 3 types of advertisements to increase social distancing/staying at home.<br>|
| No Intervention: Control Group<br>Control Group will be people who will not receive any advertisements. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mobility | Amount of time that participants are outside of their primary location/home | 7 days |