The Effects of Breakfast on Mental Workload

Study Overview
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Brief Summary
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The aim of the study is to investigate the influence of nutritive (high-protein or high-carbohydrate) and non-nutritive (low energy) breakfast on psychological and physiological responses of mental workload during multitasking in healthy volunteers.

Official Title
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The Effects of Nutritive and Non-nutritive Breakfast on Subjective Mental Workload During Multitasking - a Pilot Study in Healthy Volunteers

Conditions
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Healthy Subjects

Intervention / Treatment
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* Dietary Supplement: Breakfast juice


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: eats usually breakfast use computer mouse with right hand normal sleep-wake rhythm between 9 pm and 8 am in females hormonal contraception Exclusion Criteria: gastrointestinal disease, diabetes or any other significant major medical morbidity milk allergy lactose intolerance smoking excess use of alcohol, coffee, tea, cola drinks (> 10 doses/day) pregnancy and breast feeding no medication or dietary supplements influencing measured responses BMI > 30 kg/m2 or < 18 kg/m2

Ages Eligible for Study
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Minimum Age: 22 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Dietary supplement: high-protein breakfast<br>high-protein juice | Dietary Supplement: Breakfast juice<br>* single dose (300 ml) in the morning of study day, 3 separate sessions (high-protein vs. high-carbohydrate vs. low-calorie juice), total duration 3 weeks<br>|
| Active Comparator: Dietary supplement: high-carbohydrate breakfast<br>high-carbohydrate juice | Dietary Supplement: Breakfast juice<br>* single dose (300 ml) in the morning of study day, 3 separate sessions (high-protein vs. high-carbohydrate vs. low-calorie juice), total duration 3 weeks<br>|
| Placebo Comparator: Dietary supplement: low energy breakfast<br>low-calorie juice | Dietary Supplement: Breakfast juice<br>* single dose (300 ml) in the morning of study day, 3 separate sessions (high-protein vs. high-carbohydrate vs. low-calorie juice), total duration 3 weeks<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Brain measures of mental workload (ERP 300 amplitude and latency) and heart rate |  | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Subjective mental workload and mood measurement assessed using visual analogue scale in response to test meal. |  | 1 day | 
| cognitive function measurements |  | 1 day | 
| Blood concentration of glucose |  | 1 day | 
| salivary cortisol |  | 1 day | 
| Blood concentration of tryptophan in relation to other large neutral amino acids |  | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Mental workload, Multitasking, Protein, Tryptophan