Metabolic Effects of Treatment of Chronic Periodontitis in Non-diabetic Subjects

Study Overview
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Brief Summary
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This study was aimed at assessing the effects of non-surgical periodontal treatment (NSPT) of chronic periodontitis on insulin sensitivity, glucose tolerance, and serum C-reactive protein(CRP) level amongst non-diabetic subjects.

Detailed Description
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Subjects with chronic periodontitis will undergo non-surgical periodontal treatment (NSPT) consisting of a complete scaling, polishing, root planning, and the irrigation of periodontal pockets with a 10% povidone iodine solution. Periodontal parameters (plaque index, gingival bleeding index, pocket depth, and clinical attachment loss), insulin sensitivity using KITT, glucose tolerance using oral glucose tolerance test and serum CRP level by immunoturbidimetry will be measured before and 3 months after the NSPT.

Official Title
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Effects of Non-surgical Treatment of Chronic Periodontitis on Insulin Resistance and Glucose Tolerance in Non-diabetic Subjects

Conditions
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Periodontitis, Prediabetes

Intervention / Treatment
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* Procedure: non-surgical periodontal treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Chronic periodontitis Non diabetic individual Exclusion Criteria: Known diabetes Periodontal treatment less than 6 months prior to inclusion Having less than 20 natural teeth

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: non-surgical periodontal treatment<br>One session of non-surgical periodontal treatment consisting of a complete scaling, polishing, root planning, and the irrigation of periodontal pockets with a 10% povidone iodine solution. | Procedure: non-surgical periodontal treatment<br>* One session of complete scaling, polishing, root planning, and the irrigation of periodontal pockets with a 10% povidone iodine solution<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glucose tolerance | change in 2-hour post load blood glucose | 3 months | 
| Insulin sensitivity | change in glucose disappearance rate during the short insulin tolerance test | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Composite periodontal health | Change in plaque index, gingival bleeding index, pocket depth, and clinical attachment loss | 3 months | 
| Inflammation | change in Serum CRP | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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periodontitis, diabetes, prevention, impaired glucose tolerance, insulin resistance