Intestinal Microbiota of Breast Cancer Patients Undergoing Chemotherapy

Study Overview
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Brief Summary
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To date, few studies have addressed the link between gut microbiota and breast cancer chemotherapy, and previous studies have only provided a link between the gut and breast cancer.

Detailed Description
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To date, few studies have addressed the link between gut microbiota and breast cancer chemotherapy, and previous studies have only provided a link between the gut and breast cancer.At present, studies on the interaction mechanism between intestinal flora and breast cancer mainly focus on two aspects: first, intestinal flora affects the occurrence and progress of breast cancer by affecting estrogen metabolism;Second, intestinal flora can influence the occurrence and treatment of breast cancer by affecting the regulation of the immune system.However, the specific types (or groups) of bacteria that promote the occurrence, development and mechanism of breast cancer still need to be further studied.In addition, since most of the current clinical studies on microorganisms and breast cancer are small sample studies, the accuracy of their conclusions remains to be studied.

Official Title
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Intestinal Microbiota of Breast Cancer Patients Undergoing Chemotherapy

Conditions
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Microbiota

Intervention / Treatment
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* Drug: cyclophosphamide


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged 18 to 65 years First use of chemotherapy after breast cancer Exclusion Criteria: Pregnancy Lactation Cigarette smoking Alcohol addiction Hypertension Diabetes mellitus Lipid dysregulation BMI > 27 Recent (< 3 months prior) use of antibiotics, probiotics, prebiotics, symbiotics, hormonal medication, laxatives, proton pump inhibitors, insulin sensitizers or Chinese herbal medicine History of disease with an autoimmune component, such as MS, rheumatoid arthritis, IBS, or IBD History of malignancy or any gastrointestinal tract surgery

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control group<br>20 healthy volunteers were included in the healthy control group | |
| Disease group<br>First chemotherapy for breast cancer | Drug: cyclophosphamide<br>* First use of chemotherapy after breast cancer<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Transcriptional changes in gut microbiota | The microbiota measured by 16S rRNA gene | baseline,1 day,7 day,14 days,22 days,29 days,36 days,44days,51days,58days,66days,73days,80days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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gut microbiota, 16S rRNA gene, breast cancer chemotherapy