linjc16/ctgov huggingface dataset:
Histopathological Diagnosis of Adenomyosis

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to develop and evaluate a hysteroscopic endo-myometrial biopsy for diagnosing adenomyosis.

Official Title
-----------------
The Diagnostic Accuracy of Hysteroscopic Endomyometrial Biopsy in Adenomyosis

Conditions
-----------------
Adenomyosis

Intervention / Treatment
-----------------
* Procedure: hysteroscopic endo-myometrial biopsy
* Device: ultrasound


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: females complaining of pelvic congestion: dysmenorrhea, dyspareunia, chronic pelvic pain, menorrhagia, metrorrhagia Exclusion Criteria: refusal of the patient to get enrolled in the study

Ages Eligible for Study
-----------------
Minimum Age: 38 Years
Maximum Age: 52 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: adenomyosis<br>females attending the gynecology outpatient clinic complaining of chronic pelvic congestion will get enrolled in the study. Two dimensional ultrasonography will be performed to asses the presence or absence of adenomyosis or any associated lesions. All the patients were then be subjected to office hysteroscopy and endo-myometrial biopsies will be taken. Histopathological examination of the samples will then be done. From these recruited patients, some will be indicated to perform hysterectomy. The final diagnosis will then be based on the histopathological examination of the specimen retrieved from hysterectomy. The accuracy of the ultrasound and the hysteroscopic endo-myometrial biopsy will then be compared and assessed. | Procedure: hysteroscopic endo-myometrial biopsy<br> <br> Device: ultrasound<br>* two dimensional trans-vaginal ultrasonography<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of participants with diagnosis of adenomyosis cases |  | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
adenomyosis
Human Selenoprotein P Concentration With Glucose Tolerance Status

Study Overview
=================
Brief Summary
-----------------
Recently, seslenium(Se) has known as important regulator in metabolic status, lipid profile, atherosclerosis progression. SEPP1(selenoprotein P1)is a secreted protein from mainly liver. This protein is used as an index of selenium nutritional status. The association between the concentration of SEPP1(selenoprotein P1) in normal glucose tolerance,impaired glucose tolerance, type 2 diabetes is still a matter of debate. This cross sectional study will evaluate whether glucose status is matter in SEPP1 level.

Official Title
-----------------
Human Selenoprotein P Concentration With Glucose Tolerance Status

Conditions
-----------------
SEPP1 Levels in Differnet Glucose Tolerance Status

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 20-80 years old Not severe medical condition Exclusion Criteria: metformin, insulin using type 2 diabetes

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Normal, IGT, T2DM<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Clinical Study of Imaging and Endoplant-related Mechanical Complications After Long Segment Fixation and Fusion of Degenerative Lumbar Scoliosis (DLS)

Study Overview
=================
Brief Summary
-----------------
There is a high probability of mechanical complications in patients with degenerative lumbar scoliosis after long segment fixation and fusion, and there are few studies on distal borderline kyphosis deformity/failure. This study was designed to retrospectively analyze the patients with degenerative lumbar scoliosis (DLS) who underwent posterior selective decompression and long segment fixation and fusion surgery in the lumbar spine department of our hospital from April 2009 to May 2016. Patients' basic data, surgical data and preoperative, immediate postoperative and follow-up imaging data were collected to study the incidence of distal mechanical complications, risk factors and their relationship with clinical symptom scores in DLS patients undergoing posterior selective decompression and long segment fixation and fusion. It has guiding significance for clinical operation decision making.

Official Title
-----------------
Clinical Study of Imaging and Endoplant-related Mechanical Complications After Long Segment Fixation and Fusion of Degenerative Lumbar Scoliosis (DLS)

Conditions
-----------------
Degenerative Scoliosis

Intervention / Treatment
-----------------
* Procedure: Long Segment Fixation and Fusion


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age ≥45 years old; The number of fixed vertebral bodies ≥5, and the upper instrumented vertebra (UIV) is located in the thoracolumbar segment; Third generation total pedicle screw internal fixation system; Follow-up time ≥24 months; Complete clinical and imaging data. Exclusion Criteria: Idiopathic scoliosis, neuromuscular scoliosis, non-structural scoliosis, spinal tumors, spinal tuberculosis, ankylosing spondylitis, humman's disease, history of spinal surgery, history of spinal trauma, and history of hip surgery

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Long Segment Fixation and Fusion|Long Segment Fixation and Fusion|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Imaging and Endoplant-related Mechanical Complications | PJK, DJK | 2019.1.1-2025.12.31 |
Study to Assess Dasatinib in Patients With Core Binding Factors Acute Myelogenous Leukemia

Study Overview
=================
Brief Summary
-----------------
In patients with Core Binding Factors Acute Myelogenous Leukemia, the level of Minimal Residual Disease after chemotherapy is predictive of relapse. The relapse risk is also increased in case of mutations of receptors tyrosine kinase. For patients with a high Minimal Residual Disease level at the end of consolidation or in molecular relapse, maintenance by the inhibitor dasatinib is proposed.

Official Title
-----------------
An Open-Label, Multicenter, Phase II Study to Assess Dasatinib in Patients With Core Binding Factors Acute Myelogenous Leukemia Refractory to Conventional Chemotherapy or in Molecular Relapse. Intergroupe Français Des leucémie aiguë myéloblastique

Conditions
-----------------
Acute Myelogenous Leukemia

Intervention / Treatment
-----------------
* Drug: dasatinib


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient presenting de novo or secondary Core Binding Factors Acute Myelogenous Leukemia Patient in first and presenting one of following criteria: Resistant Patient: decrease of less than 3 log of the Acute Myelogenous Leukemia transcript level in the bone marrow after 2 consolidations Patient in  molecular relapse : increase of of more than 1 log of the Core Acute Myelogenous Leukemia transcript level on two successive marrow samples Exclusion Criteria: Woman of childbearing potential Concurrent incurable malignacy other than Acute Myelogenous Leukemia

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: dasatinib<br> | Drug: dasatinib<br>* dasatinib 50 mg and 20 mg During one year<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| measure relapse-free survival | Number of Participants with Adverse Events as a Measure of Safety and Tolerability | 4 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Core Binding Factors, Acute Myelogenous Leukemia refractory to conventional chemotherapy, molecular relapse
Multi Marker Approach Interest in Emergency in Acute Respiratory Insufficiency Diagnostic

Study Overview
=================
Brief Summary
-----------------
Biomarkers have an interest in clinic diagnostic ,therapeutic and prognosis in pathophysiologic situation including cardiovascular.But interest of biomarkers in diagnostic care of severe acute respiratory insufficiency remains to clear. We propose to determine the more relevant marker combination in this case.

Detailed Description
-----------------
In urgence of a severe acute respiratory insufficiency,for thanks to an approach diagnostic, therapeutic and prognostic we propose to determine the more relevant biomarker combination. An expert committee will compare the biomarker diagnostic and prognostic relevance thanks to all elements clinico-biological and patient monitoring.

Official Title
-----------------
Multi Marker Approach Interest in Emergency in Acute Respiratory Insufficiency Diagnostic

Conditions
-----------------
Acute Respiratory Insufficiency

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Oxygen saturation below or equal to 92% in ambient air. Respiratory frequence above 25 cycle per minute Exclusion Criteria: Minors Pregnant or lactating women Patient without social security Patient hospitalize without consent Chest pain with acute coronary electro-cardiographic change leading immediate achievement of a diagnostic coronary angiography and/or therapeutic Pneumothorax

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Acute respiratory diseases.<br>Patient admit in emergency or intensive care unite with acute respiratory insufficiency. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Acute respiratory insufficiency respiratory, Biomarkers, Emergency, Intensive care unit, Prospective, Patient hospitalize in emergency or in intensive care unit, for acute respiratory insufficiency
Comparison of Self and Clinician Administered Rating Scales in Patients With ADHD

Study Overview
=================
Brief Summary
-----------------
The primary objective is to establish the concurrent validity of the clinician administered Attention Deficit Hyperactivity Disorder-Rating Scale (ADHD-RS) and the patient administered Attention Deficit Hyperactivity Disorder Self Report Scale (ASRS) v1.1 Symptom Checklist.

Official Title
-----------------
Comparison of Self and Clinician Administered Rating Scales in Patients With Attention Deficit Hyperactivity Disorder (ADHD)

Conditions
-----------------
Attention-Deficit/Hyperactivity Disorder (ADHD)

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of ADHD Age 13-65* *Parental consent and patient's assent will be obtained for minors participating in this protocol (only adolescents aged 13-18 yrs old will be included in the MGH site) Exclusion Criteria: Inability to reliably report ADHD symptoms at the discretion of the investigator

Ages Eligible for Study
-----------------
Minimum Age: 13 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| MGH 1<br>Adolescents with Attention Deficit Hyperactivity Disorder (ADHD) | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The ADHD-RS and ASRS v1.1 Symptom Checklist scales |  | Weeks 1, 2, 3, 4, 5, 6, 7, or 8 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Attention Deficit Hyperactivity Disorder (ADHD), Adolescent
Evaluation of Dentists Burnout in Turkey

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to determine the level of burnout in Turkish dentists. The Copenhagen Burnout Inventory of 19 questions will be used to assess burnout; and 4 more about; gender, occupational age, institution and title. All surveys will be conducted online and we plan to reach approximately 400 participants. After the burnout levels are determined, it will be statistically investigated whether there is a difference between the groups according to gender, occupational age, institution and title.

Official Title
-----------------
Evaluation of Dentists Burnout in Turkey

Conditions
-----------------
Burnout, Psychological

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Being a dentist who is still working Accepted electronically to participate in our study Completed and submitted our electronic questionnaires successfully Exclusion Criteria: Did not answer all questions of survey

Ages Eligible for Study
-----------------
Minimum Age: 22 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Participants' burnout levels | Participants' burnout levels will measure by cophenag burnout inventory | 1 month |
Application of Clinical Metagenomics in the Diagnosis of Ascites

Study Overview
=================
Brief Summary
-----------------
Infection of the ascitic fluid is a serious complication associated with high morbidity and mortality. This fluid is often colonized with bacteria that can cause infection of the peritoneum and possibly sepsis. Many bacteria of the human intestinal microbiome can't be cultured by standard methods; therefore it seems likely that many of the relevant bacteria are not discovered in routine diagnostics, but may be relevant to pathogenesis. Culture-independent approaches such as NGS (Next generation Sequencing) have in principle made it possible to study or prove complex microbial colonization. Because NGS is a relatively new technology, microbiological diagnostic protocols need to be further customized and refined to integrate with the standard diagnostic workflow, if necessary. For microbiological diagnostics, material is collected from the appropriate ascites patients and sent for microbiological diagnostics. Afterwards the cultural diagnostics are carried out as part of the patient care at the university hospital. In this study the investigators plan to use these samples to analyze and compare the presence of bacteria by NGS in parallel to the culture diagnostics, and then compare it to the patients' gut microbiome, to understand the possible effect of the microbiome on ascites pathogenesis and outcome.

Official Title
-----------------
Establishing of Next Genaration Sequencing Methods for Microbiological Diagnostic of Ascitic Fluid Infections

Conditions
-----------------
Ascites Infection

Intervention / Treatment
-----------------
* Diagnostic Test: Next generation sequencing


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male and female patients ≥ 18 years of age Samples from patients who have ascites puncture to exclude infection Written consent of the patient after clarification Exclusion Criteria: Minor patients Non-consenting patients Samples without sufficient residual material after standard diagnostics Samples from patients who have not consented to the examination.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Next generation sequencing|we will investigate the sensitivity and specificity of next generation sequencing as a diagnostic tool in ascites infections.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The comparative assessment of about 50 patients |  | 12-18 Months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Metagenomics
Development of Pharmacokinetics Model in Pregnancy Women and Fetus

Study Overview
=================
Brief Summary
-----------------
Pharmacokinetics analysis and development of pharmacokinetics model in pregnancy women and fetus

Conditions
-----------------
Preterm Labor, Preterm Premature Rupture of Membrane (PPROM)

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 20 <= age < 50 pregnant women who were administered intramuscular dexamethasone (ex) preterm labor) pregnant women who were administered PO clarithromycin (ex) PPROM/intrauterine infection or inflammation) Exclusion Criteria: who deny the study entrance who administered study drug before transfer to tertiary hospital

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analysis of drug concentration | drug (dexamethasone, clarithromycin) | Day 1 after delivery |
EBUS-TBNA for Diagnosis of Mediastinal Lymphadenopathy

Study Overview
=================
Brief Summary
-----------------
This study aims on the combinatorial results of cytology, histopathology and microbiology obatined by EBUS-TBNA for unselected mediastina lesions.

Detailed Description
-----------------
A number of studies have proved EBUS-TBNA to be useful for lymph node staging in lung cancer. The diagnostic performance is equivalent to mediastinoscopy while the invasiveness is far less. This study primarily focusing on merged approach of cytology, histopathology and microbioloogy obatined by EBUS-TBNA for unselected mediastina lesions.

Official Title
-----------------
EBUS-TBNA for Diagnosis of Mediastinal Lymphadenopathy

Conditions
-----------------
Mediastinal Lymphadenopathy, Lung Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age > 18 years old mediastinal lymphadenopathy on Chest CT scan with a short-axis > 10mm Exclusion Criteria: patients intolerant to bronchoscopy exam unstable vital sign (Blood pressure, heart rate, breath rate)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| lymphadenopathy<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnostic rate |  | Participant will be followed within an average of three months |
Work-related Stress Among Recently Graduated Midwives Practicing in the Delivery Room

Study Overview
=================
Brief Summary
-----------------
Work stress results from an imbalance between the worker's hopes and work's conditions. Midwifes are exposed to emergency situations (newborn distress, neonatal resuscitation, foetal abnormal heart rythm, delivery hemorrhage, …), which can cause stress and sometimes lead to burnout.

Detailed Description
-----------------
the aim of the study is to describe Work-related stress among recently graduated midwives practicing in the delivery room

Official Title
-----------------
Work-related Stress Among Recently Graduated Midwives Practicing in the Delivery Room

Conditions
-----------------
Recently Graduated Midwives Practicing in the Delivery Room

Intervention / Treatment
-----------------
* Other: data collection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Midwives graduated for less than three years in France Practicing in the delivery room Whatever the duration of exercise in the delivery room Agreeing to participate in the study Exclusion Criteria: No Agreeing to participate in the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| group recently graduated midwives practicing in the delivery room<br>Midwives graduated for less than three years and practicing in the delivery room | Other: data collection<br>* Work-related stress evaluation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Work-related stress | Work-related stress evaluated using Perceived Stress Scale (PPS10). PPS10 includes 10 items evaluating the degree to which an individual has perceived life as unpredictable, uncontrollable and overloading over the previous month. Each item is coded from 1 to 4 points: never, almost never, sometimes, fairly often and very often. The overall score ranges from 0 to 40 points. | Day 0 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
midwives, Work-related stress, delivery room