the Application of Cardiopulmonary Exercise Testing in Assessment Outcome of Patients With Pulmonary Hypertension

Study Overview
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Brief Summary
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cardiopulmonary exercise test evaluate patients with pulmonary hypertension before and after medical or balloon pulmonary angioplasty treatment

Detailed Description
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patients diagnosed with pulmonary hypertension, including pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension, will be evaluated by cardio pulmonary exercise test before and after medical or balloon pulmonary angioplasty treatment

Official Title
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the Application of Cardiopulmonary Exercise Testing in Assessment Outcome of Patients With Pulmonary Hypertension

Conditions
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Pulmonary Hypertension, Chronic Thromboembolic Pulmonary Hypertension, Pulmonary Arterial Hypertension Associated With Schistosomiasis (Disorder)

Intervention / Treatment
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* Device: balloon pulmonary angioplasty


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: pulmonary arterial hypertension;( WHO1) chronic thromboembolic pulmonary hypertension; pulmonary arterial hypertension due to other cause; Exclusion Criteria: massive hemoptysis; unable to accomplish cardiopulmonary exercise testing due to neuromuscular disorders; recent recurrent syncope; pulmonary hypertension due to hypoxia; pulmonary hypertension due to left heart diseases.

Ages Eligible for Study
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Minimum Age: 5 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| cardiopulmonary exercise testing<br>patients diagnosed with pulmonary hypertension, including pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension, were evaluated by cardiopulmonary exercise testing before and after medical or balloon pulmonary angioplasty treatment | Device: balloon pulmonary angioplasty<br>* patients with chronic thromboembolic pulmonary hypertension who underwent balloon pulmonary angioplasty<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| all cause mortality | all cause mortality | 5 years | 
| mean pulmonary arterial pressure after treatment | the mean pulmonary arterial pressure of patients with chronic thromboembolic pulmonary hypertension after balloon pulmonary angioplasty treatment | 5 years | 
| achievement of low risk | patients with chronic thromboembolic pulmonary hypertension achievement of low risk after balloon pulmonary angioplasty | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| deterioration of WHO function | deterioration of WHO function | 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Chronic Thromboembolic Pulmonary Hypertension, Pulmonary Arterial Hypertension, balloon pulmonary angioplasty, cardiopulmonary exercise test