Epileptogenic Zone's Cartography by Quantification of EEG's Signal and Intracerebral Stimulation.

Study Overview
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Brief Summary
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Epilepsy is a devastating chronic disease due to multiple causes that affect close to 50% of the world's population. Although effective, epilepsy surgery fails in many cases, the percentage of patients free from crisis on a long term (≥ 5 years) varies from 27% to 66% according to the kind of epilepsy. It is in this context that EPISTIM is interesting, and its aims isb a better electrophysiology delimiting of cortical networks that imply the genesis of seizures with the aim to improove surgery results. This study will rely on the intracerebral records and on corticales electrical stimulation as they are currently routinely used by epileptic patients candidates for surgery.

Official Title
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Epileptogenic Zone's Cartography by Quantification of EEG's Signal and Intracerebral Stimulation.

Conditions
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Epilepsy

Intervention / Treatment
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* Other: Functional stereotaxic exploration


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria : Patient from 5 to 65 years (L1121-7 L1122 2 CSP), including legally protected or unable to give his consent (L1121-8 CSP). Written approval of inclusion in the study from the patient or his legal representative. Patients with partial Epilepsy Drug Resistant , justifying a SEEG exploration. Exclusion Criteria : Patient under 5 years. Patient over 65 years. Pregnant or breastfeeeding women (L1121-5 CSP). Patient deprived of liberty as a result of a judicial or administrative decision (L1121-6 CSP). Patients over 18 years unable to give their free consent and not subject to a legal protection order.

Ages Eligible for Study
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Minimum Age: 5 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Partial Epilepsy Drug Resistant<br>Patients with partial Epilepsy Drug Resistant , justifying a SEEG exploration. | Other: Functional stereotaxic exploration<br>* Visual analysis : in order to define the level of cortical resections. Epileptogenic maps : calculated for each crisis and for all crisis in general. Connectivity maps : calculated for each site stimulated at low-frequency. Post-operative evaluation : in order to assess the extent of resection.<br>* Other names: sEEG;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual analysis | Visual analysis : in order to define the level of cortical resections. | up to one hour | 
| Epileptogenic maps | Epileptogenic maps : calculated for each crisis and for all crisis in general. | up to 10 min | 
| Connectivity maps | Connectivity maps : calculated for each site stimulated at low-frequency. | up to 10 min | 
| MRI | Post-operative evaluation : in order to assess the extent of resection. MRI : 3D-T1 | up to one hour | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Epilepsy, Surgery candidate, EEG's Signal