Impact of Health Lifestyle on Body Weight

Study Overview
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Brief Summary
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Pharmacotherapy becomes an important and effective approach to improve body weight. However, it still remains unclear how to manage potential fluctuation after its cessation. Lifestyle change is the foundation and included as a part of clinical routine in real-world, therefore, we plan to conduct a prospective observational study to assess the impact of health lifestyle along with its compliance on body weight in Chinese people who live with obesity or overweight and are off-pharmacotherapy trial. The aim of this study is to examine the impact of health lifestyle along with its compliance on body weight related parameters in 6 months at 3 monthly intervals from treatment. In addition, body weight related results will be described.

Detailed Description
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Novel pharmacotherapy is emerging, leading to substantial and sustained improvement in body weight compared with placebo in clinical trials. However, there is no evidence on management of body weight in real world setting after cessation of treatment. Body weight fluctuation is a pivotal difficulty for obese subjects who left off pharmacotherapy. It would be interesting to investigate the impact of real-world health lifestyle and its compliance in this clinical situation and probe into factors affecting compliance. Therefore, we will conduct a prospective observational study to assess the impact of health lifestyle along with its compliance on body weight in Chinese people who live with obesity or overweight and are off-pharmacotherapy trial. The aim of this study is to examine the impact of health lifestyle along with its compliance on body weight related parameters in 6 months at 3 monthly intervals from pharmacotherapy cessation. In addition, body weight related results will be described.

Official Title
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Impact of Health Lifestyle on Body Weight Post Cessation of Pharmacotherapy in Obese Subjects

Conditions
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Body-Weight Trajectory

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients who completed a pharmacotherapy trial Those who consent to this FU study Exclusion Criteria: Those who do not consent to this study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fluctuation in body weight | To examine the weight fluctuation by health lifestyle compliance from baseline | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of blood lipids | To examine the change of blood lipids by health lifestyle compliance from baseline | 6 months | 
| Change of blood glucose levels | To examine the change of blood glucose levels by health lifestyle compliance from baseline | 6 months | 
| Change of blood pressure | To examine the change of blood pressure by health lifestyle compliance from baseline | 6 months |