Prognostic Score in the Very Old ICU Patients

Study Overview
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Brief Summary
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The two main aims of the study: To investigate the relation of Frailty, Activity of daily life (ADL), Cognitive functions and Co-morbidity on survival at 30 days (and 6 months in a substudy) From the results design a prognostic score that will be validated using a subpopulation of the study cohort Two secondary aims a Survival at 6 months (in a subpopulation of the study) An inter-rater validation of the Clinical Frailty Score (CFS) (in a subpopulation) Substudies are planned with regards to the different admission categories, in particular: trauma acute respiratory failure sepsis combined respiratory and circulatory failure medical neurological conditions In some of the substudies similar groups from the VIP1 study that uses the same admission categories (except planned admissions) will be merged.

Detailed Description
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Frailty to be registered by the Clinical Frailty Scale (CFS), 1-9 point Activity of Daily life (ADL) with Katz ADL form: 0-6 points Cognition to be described by Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) questionaire, 16 questions to be asked the care-givers Co-morbidity by listing the major comorbidity with Yes or No (Yes= 1 point) and with the number of regular drugs prescribed

Official Title
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Development and Validation of a Prognostic Score in the Very Old ICU Patients (≥80 Years)

Conditions
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Aged, 80 and Over, Critical Care

Intervention / Treatment
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* Other: Cognitive assesment, Frailty assessment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ≥80 admitted to an ICU as an emergency case Exclusion Criteria: elective admissions

Ages Eligible for Study
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Minimum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Cognitive assesment, Frailty assessment|Asking relatives (using a structured questionaire) about cognitive function at admission , likewise about frailty using the Clinical Frailty Score|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 30 days survival | Proportion alive after 30 days | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Developement of a prognostic score | Developement and subsequent validation of a prognostic score from data revealed in the study: Frailty, Comorbidity, Activity of Daily life and Cognition. This score is non-existent at the moment, it is a score we will develope and test within the cohort-. No further description can be given before study is finished and analysed. | 6 months | 
| 6 months survival | Proportion alive after 6 months | 6 months | 
| Inter-rater validation of Clinical Frailty Scale (CFS) | The CFS is a simple visual scale of frailty from 1 to 9 (increasing frailty). We will in a subset of our patients use two raters to perform frailty score and compare their results using inter-rater variability tests. | At admission | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Outcome, Survival, Prognostication