Impact of Age and BMI on Liver Transplant Outcomes

Study Overview
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Brief Summary
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Prospectively enrolled retrospective chart review and Liver Transplant database review to determine the modifiable and nonmodifiable risk factors specifically relating to Living Donor Liver Transplants. To observe the impact of age and BMI on graft outcomes and whether they impact the intraoperative management, post-operative length of stay, and complications.

Detailed Description
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There has been a great deal of research into the characteristics of the donor for organ transplant, with older donors and those with more comorbidities having worse function once the organ is implanted. There has not been a great deal of research in the United States about the recipient's characteristic including age and BMI and the effects on donor organ function. With increasingly expanded criteria for organ recipients especially in the field of living donor organs the investigators plan to show the impact of older age and increased BMI on newly transplanted organs.

Official Title
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The Impact of Advanced Age and High BMI on Short-term Outcomes in Live-donor Liver Transplant Recipients

Conditions
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Liver Transplant; Complications, Perioperative/Postoperative Complications

Intervention / Treatment
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* Procedure: Cadaveric
* Procedure: Living Donor


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients who received a liver transplant at UPMC- Montefiore Hospital Age> 18 Exclusion Criteria: Excludes Children (<18 years old) as they do not receive their operation under the same protocols Lost to follow-up prior to 1 year Participation in alternate research protocol that significantly altered the care they received in the perioperative period that may make their inclusion skew results.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Living Donor Liver Transplant Recipient<br>Patients who have received a living donor liver transplant. | Procedure: Living Donor<br>* Living Donor Organ Transplant<br>|
| Deceased Donor Liver Transplant Recipient<br>Patients who have received either a Deceased by Circulatory Death or Deceased by Brain Death Liver Transplant | Procedure: Cadaveric<br>* Cadaveric Organ Transplant<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Graft Function 30 day | How well does the organ function | 30 day | 
| Mortality | Mortality at 1 year | 1 year | 
| Graft Survival 1 year | Survival of Organ at 1 year | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Perioperative Complications | Any complications in the perioperative period | 30 day | 
| Length of Stay- Total and ICU | How long after surgery before patient is discharged from ICU and from Hospital | Up to 6 months | 
| Duration of Intubation/Ventilation | Time from Surgery End to Extubation or no longer requiring ventilatory support | Up to 6 months | 
| Postoperative Complications | Complications in the postoperative period- Renal, Infectious Disease, Pulmonary, Cardiac, Transplant related, Reintubation, Reoperation | Up to 6 months | 
| Blood Transfusion | Amount of blood transfusion required intraoperatively | Up to 2 days | 
| Vasoactive Medication | Amount and Type of Vasoactive Medication used at procedure end | Up to 2 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Age Related Outcomes, BMI related outcomes, Liver Transplantation