Source Monitoring Déficit in Neuropsychiatric Population

Study Overview
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Brief Summary
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the investigators will measure source-monitoring ability in patients with several neuropsychiatric condition and in healthy controls appaired in age, sex and educational level. Source-monitoring will be measured thanks to internal- and reality-monitoring informatic tasks.The investigators hypothesized patients with fronto-temporal abnormalities would show more marked deficits than patients with only frontal abnormalities.

Detailed Description
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Source-monitoring abilities will be measured thanks to reality-monitoring testing (i.e. the ability to distinguish internal-generated events from external ones) and internal-monitoring testing (i.e. the ability to distinguish an imagined source from a performed one). A source-monitoring deficit have been demonstrated in patients with psychiatric conditions such as schizophrenia and seems linked to frontotemporal abnormalities (frontotemporal dysconnectivity and temporal hypoactivity). With a total of 150 patients, the investigators will include 30 patients per group: patients with pre-dementia stage Alzheimer, Alzheimer, Fronto-Temporal dementia, Lewy Body dementia or Parkinson and Bipolar Disorder, with the hypothesis that Bipolar Disorder patients will present less marked deficit. The investigators will recruit 150 healthy controls.

Official Title
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Source Monitoring Déficit in Neuropsychiatric Population

Conditions
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Psychiatric Disorder

Intervention / Treatment
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* Other: Monitoring source test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects who gave their free and informed consent; Men and women; Aged 18 to 80; Having normal or corrected vision; Mastering the French language (read and spoken); All subjects will not have a working memory deficit preventing the test from being passed (MMSE short version):AM patients should have a score of <MMSE <26; Patients with pre-dementia AD will be diagnosed according to Dubois criteria (Dubois et al., 2016); patients with early FTD will be diagnosed according to Rascovsky's criteria (Rascovsky et al., 2011); Patients with DCL will be diagnosed according to McKeith's criteria (McKeith et al., 2005), TBP patients will be diagnosed using DSM 5 criteria (Arlington VA, 2013). Exclusion Criteria: Inadmissibility of the consent or refusal of the subject. Patients under guardianship

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: 2 arms
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patients with with neuropsychiatric conditions<br>In this arm, five groups : Patients with DFT, diagnosed according Racovsky criteria Patients with Lewi Body dementia, diagnosed according McKeith criteria Patients with pre-demential Alzheimer, diagnosed according Dubois criteria Patients with Alzheimer, diagnosed according MMSE Patients with bipolar disorder, diagnosed according DSM 5 | Other: Monitoring source test<br>* Internal- and external-monitoring correct responses and inversions<br>|
| Active Comparator: Healthy subjects<br>Healthy controls appaired in age, sex and educational level | Other: Monitoring source test<br>* Internal- and external-monitoring correct responses and inversions<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| measure source memory performance | in patients with neuropsychiatric disorders with or without temporal involvement (pre-dementia Alzheimer's disease, Alzheimer's disease - AD, fronto-temporal dementia - DFT, Lewy body dementia - DCL and bipolar disorder - TBP) and healthy volunteers matched in age, gender, and level of education. | one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| measure the recognition of distractors | words not presented during the source monitoring test phase but presented during the recall phase. This measure will allow us to avoid that a disturbance invading the working memory or attentional capacities does not compromise the good realization of the task. | one year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Bipolar Disorder, Source-monitoring