Developing Fast Pediatric Imaging

Study Overview
=================
Brief Summary
-----------------
This research study is evaluating the investigational software for magnetic resonance imaging (MRI) systems and techniques to process magnetic resonance (MR) images

Detailed Description
-----------------
The purpose of the study is to develop new technologies for MRI systems. The new technologies should improve MRI capabilities in terms of how sensitive, specific, and efficient they are. The overall goal is to get better measurements of the brain tumor tissue(s). In this research study, the investigators want to learn more about investigational software and about techniques to process MR images. The testing of investigational software will allow the investigators to improve the image quality. As part of the testing process, the investigators will collect more MR images of the brain, and improve current image reconstruction methods. This will allow a more precise analysis of MR images and potentially better assessment of the brain tumor tissue volume.

Official Title
-----------------
Developing Fast Pediatric Imaging

Conditions
-----------------
Pediatric Low-grade Gliomas

Intervention / Treatment
-----------------
* Other: Wave-CAIPI


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Infants, children and adults who have been diagnosed with Low Grade Glioma Healthy volunteers - Children from age 0 to adults with no upper age limit or; Diagnosed with LGG and being treated at DFCI; Exclusion Criteria: Electrical implants such as cardiac pacemakers or perfusion pumps; Ferromagnetic implants such as aneurysm clips, surgical clips, prosthesis, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants; Ferromagnetic objects such as jewelry or metal clips; Women of childbearing age who are seeking to become pregnant, who are breastfeeding, or who suspect they may be pregnant; Pre-existing medical conditions including a likelihood of developing seizures or claustrophobic reactions; Any greater than normal potential for cardiac arrest

Ages Eligible for Study
-----------------
Minimum Age: 0 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Primary Testing Group<br>This scan is in the same imaging session as the participant's scheduled clinical MRI and is no longer 15 minutes Wave-CAIPI will be use to enable a 40-60 s acquisition per contrast at 0.9-mm isotropic resolution Wave-CAIPI will be used to acquire a 4-echo GE-SE time-series at 1.5-mm isotropic resolution | Other: Wave-CAIPI<br>* wave-CAIPI technology, a data acquisition / reconstruction scheme designed to optimally exploit available information in modern multi-channel receivers and in multi-contrast/time-series data for improved image encoding<br>|
| Experimental: Software Testing Group<br>Participants will receive hour research-only scan Wave-CAIPI will be use to enable a 40-60 s acquisition per contrast at 0.9-mm isotropic resolution Wave-CAIPI will be used to acquire a 4-echo GE-SE time-series at 1.5-mm isotropic resolution | Other: Wave-CAIPI<br>* wave-CAIPI technology, a data acquisition / reconstruction scheme designed to optimally exploit available information in modern multi-channel receivers and in multi-contrast/time-series data for improved image encoding<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Wave-CAIPI validation | The outcome measure for this project will be that the rapid scan from Wave-CAIPI can provide equivalent diagnostic quality to that of standard clinical acquisitions which is performed at much slower speed. This will be assess using visual qualitative assessment by experienced radiologists on the project. | 2 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Neuro Oncology