Ullevål PersonalityProject

Study Overview
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Brief Summary
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Ullevål PersonalityProject is a ranomized controlled trial of treatment of patients with personality disorder. It's main purpose is to test the effect of a long-term combined treatment program compared with eclectic individual therapy for patients with personality disorders. The main study hypothesis is that long-term combined treatment is superior to eclectic individual therapy with respect to improvement in personality functioning, psychosocial functioning, symptoms, interpersonal problems, and self destructive behavior for poorly functioning patients with personality disorders.

Detailed Description
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Ullevål PersonalityProject is a ranomized controlled trial of treatment of patients with personality disorder. It's main purpose is to test the effect of a long-term combined treatment program compared with eclectic individual therapy for poorly functioning patients with personality disorders. The experiment treatment is guided by written treatment guidelines and comprises: 18 weeks intensive day treatment followed by long-term outpatient combined group psychotherapy and individual therapy for 4 and 2,5 years respectively. The control treatment comprises: 1. eclectic psychotherapy, here understood as psychotherapy according to the preference and regular practice of the therapist. 120 patients with personality disorders admitted to Department of personality psychiatry, Psychiatric division, Ullevål University Hospital are randomized to either experiment or control condition. The patients are evaluated at baseline and after 8, 18, 36, 72 months. The evaluations comprise a large battery of psychological tests and structured interviews.

Official Title
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Ullevål PersonalityProject. A Randomized Controlled Trial of Intensive Daytreatment Followed by Outpatient Long-term Combined Treatment Compared With Eclectic Individual Therapy for Patients With Personality Disorders

Conditions
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Personality Disorders

Intervention / Treatment
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* Behavioral: Combined psychotherapy
* Behavioral: Outpatient individual psychotherapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with personality disorders admitted to Department for personality psychiatry, Psychiatric division, Ullevål University Hospital Exclusion Criteria: Schizotypal personality disorder, antisocial personaliy disorder, current alcohol or drug dependence, developmental disorders (e.g. Asperger), symptoms due to organic conditions, and lack of a permanent residence.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Combined psychotherapy<br>18 weeks day hospital treatment followed by long-term outpatient combined group- and individual psychotherapy | Behavioral: Combined psychotherapy<br>* 18 weeks day hospital treatment followed by long-term outpatient combined group-and individual psychotherapy<br>* Other names: CP;|
| Active Comparator: Outpatient individual psychotherapy<br>Eclectic individual psychotherapy in outpatient private practice | Behavioral: Outpatient individual psychotherapy<br>* Eclectic individual psychotherapy in private practice<br>* Other names: OIP;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Psychosocial functioning |  | The outcomes will be assessed after 8, 18, 36, and 72 months: | 
| symptom distress |  | after 8, 18, 36 and 72 months | 
| self esteem |  | after 8, 18, 36 and 72 months | 
| interpersonal problems, |  | after 8, 18, 36 and 72 months | 
| self destructive behavior, |  | after 8, 18, 36 and 72 months | 
| personality pathology, |  | after 36 and 72 months | 
| quality of life, |  | after 8, 18, 36 and 72 months | 
| health care utilization after |  | after 8, 18, 36 and 72 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| affect consciousness |  | after 36 months | 
| reflective functioning |  | after 36 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Personality disorders,, Day treatment,, Group psychotherapy,, Combined psychotherapy,, Outcome,, Attachment pattern