Regional Distribution of Ventilation to Assess Respiratory Muscle Dysfunction

Study Overview
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Brief Summary
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The aim of this study is to better discriminate respiratory muscle dysfunction by comparing the measurements of thoracoabdominal motion obtained by an optoelectronic recording and the conventional tests of respiratory muscle strength. The final objective is to better select in the future the patients who need more specific assessment of diaphragmatic function like maximal transdiaphragmatic pressure measurement and phrenic nerve stimulation.

Detailed Description
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All patients which had suspected respiratory muscle dysfunction will have usual exploration of the respiratory muscles according to the clinician prescription. These explorations can include : Lung volumes in seating and supine position Maximal inspiratory and expiratory pressures Maximal sniff pressures And when diaphragmatic dysfunction is suspected : Maximal transdiaphragmatic pressure Phrenic nerve conduction These patients will also beneficiate to the determination of volume variations of the upper rib cage, the lower rib cage and the abdominal compartments by using Opto-electronic plethysmography.

Official Title
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Construction of a Database to Identify Early Indicators of Respiratory Muscle Dysfunction in Neuromuscular Patients From the Optoelectronic Plethysmography Assessment of the Thoracoabdominal Motion

Conditions
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Respiratory Failure, Neuromuscular Disorder, Diaphragmatic Paralysis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: suspicion of respiratory muscle dysfunction indication of diaphragm exploration Exclusion Criteria: acute respiratory failure

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| respiratory muscle dysfunction patients<br>Neuromuscular patients | |
| diaphragmatic dysfunction<br>patients who present orthopnea, recruitment of accessory muscles, abdominal paradox, respiratory dysfunction or dyssynchronous movement | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| compartmental distribution of the inspired/expired volumes | Measurements of the thoraco-abdominal motion and of the global lung volume changes. Measurements will be done during spontaneous breathing and during vital capacity maneuvers. Therefore the tidal volume, the inspiratory capacity and the expiratory reserve volume will be measured in liters and for each compartiment (upper thorax, lower thorax, abdomen) contribution of these volumes will be expressed in percentage. | 1 hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| left side and right side contribution to the inspired/expired volumes | Measurements will be done during spontaneous breathing and during vital capacity maneuvers. Therefore the tidal volume, the inspiratory capacity and the expiratory reserve volume will be measured in liters and each side contribution of these volumes will be expressed in percentage. | 1 hour | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Diaphragm, Abdomen, Breathing pattern, dyspnea