Sequential Oxygen Therapy Strategy for Patients With COVID-19

Study Overview
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Brief Summary
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All patients with COVID-19 were divided into three groups according to their illness: mild patient who receive conventional oxygen therapy, severe patients who receive nasal high flow oxygen inhalation or non-invasive positive pressure ventilation，all the oxygen therapy will be used as part of the standard of care. Each group will enroll 10 patients, the treatment of all patients will be continuously optimized during observation, and the incidence of respiratory failure, intubation rate, 28 day mortality rate, ICU hospitalization days, etc will be recorded and analyzed so to optimize the treatment time window of sequential oxygen therapy

Official Title
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Sequential Oxygen Therapy Strategy for Patients With COVID-19

Conditions
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Coronavirus Disease-2019

Intervention / Treatment
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* Other: oxygen treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients diagnosed with COVID-19 Aged between 18-75 years; Willing to sign the informed consent voluntarily. Exclusion Criteria: Patients with active tuberculosis, idiopathic pulmonary fibrosis, bronchial asthma, bronchiectasis, pulmonary embolism, chronic respiratory failure or other serious respiratory diseases; ② patients with serious cardiovascular and cerebrovascular diseases (malignant arrhythmia, unstable angina, acute myocardial infarction, cardiac function grade 3 or above, stroke, cerebral hemorrhage, etc.); ③ Patients with serious hepatorenal diseases (serious liver diseases refer to cirrhosis, portal hypertension and varicose bleeding, and serious kidney diseases include dialysis and kidney transplantation); ④ tumor patients who have undergone resection, radiotherapy and chemotherapy within 5 years; ⑤ patients who have difficulty in activity due to neuromuscular diseases; ⑥ patients with serious arthritis; ⑦ patients with serious peripheral vascular diseases; ⑧ Pregnant and lactating women; ⑨ with severe cognitive and mental disorders; ⑩ the clinical researchers who were participating in other interventions within one month before selection;

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Mild cases with conventional oxygen therapy<br>COVID-19 patients who were considered mild cases will receive conventional oxygen therapy in addition to standard treatment | Other: oxygen treatment<br>* different kinds of oxygen treatments will be given to patients according to their state of illness<br>|
| Moderate/Severe cases with nasal high flow oxygen inhalation<br>COVID-19 patients who were considered Moderate/Severe cases will receive nasal high flow oxygen inhalation in addition to standard treatment | Other: oxygen treatment<br>* different kinds of oxygen treatments will be given to patients according to their state of illness<br>|
| Moderate/Severe cases with non-invasive ventilation<br>COVID-19 patients who were considered Moderate/Severe cases will receive non-invasive positive pressure ventilation in addition to standard treatment | Other: oxygen treatment<br>* different kinds of oxygen treatments will be given to patients according to their state of illness<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of respiratory failure | Incidence of respiratory failure at day 28 after enrollment | 28 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 28 day mortality rate | mortality rate at day 28 after enrollment | 28 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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SARS-CoV-2, COVID-19, oxygen treatment