Dopamine Versus Norepinephrine Under General Anesthesia

Study Overview
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Brief Summary
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Participants under general anesthesia will be randomly treated with an adjusted dose dopamine or norepinephrine to elevate 10% of mean arterial pressure. Systemic hemodynamic data is recorded by PRAM and the change of cardiac index is compared between groups.

Detailed Description
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After intubation under general anesthesia, radial arterial is cannulated and pressure transducer is connected to MostCare(core technique PRAM). CI, SVRI, SVI, SVV, dp/dt and HR are recorded before and after a infusion of dopamine or norepinephrine to elevate 10% of mean arterial pressure. Changes of these hemodynamic data are compared.

Official Title
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Hemodynamic Effects of Dopamine Versus Norepinephrine Under General Anesthesia in Infant With Congenital Heart Disease

Conditions
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Anesthesia, Infant, Congenital Heart Disease, Hemodynamic Instability

Intervention / Treatment
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* Drug: norepinephrine
* Drug: dopamine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: undertake cardiac surgery for congenital heart disease Exclusion Criteria: Aortic valve or aortic disease severe arrhythmia use of cardiovascular active drugs before anesthesia need to use a combination of different cardiovascular support drugs after anesthesia

Ages Eligible for Study
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Minimum Age: 1 Month
Maximum Age: 12 Months

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: norepinephrine<br>infusion of norepinephrine with a adjusted dose to elevate 10% of mean arterial pressure | Drug: norepinephrine<br>* to treat hypotension under general anesthesia with norepinephrine<br>|
| Active Comparator: Dopamine<br>infusion of dopamine with a adjusted dose to elevate 10% of mean arterial pressure | Drug: dopamine<br>* to treat hypotension under general anesthesia with dopamine<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes of cardiac index | the differences of cardiac index between after and before the intervention (l/min/m2) | 20 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes of stroke volume index | the differences of stroke volume index between after and before the intervention (ml/m2) | 20 minutes | 
| changes of systemic vascular resistance index | the differences of systemic vascular resistance index between after and before the intervention(dyne ∙ sec ∙ m2/cm5) | 20 minutes | 
| changes of the maximal slope of systolic upstroke | the differences of the maximal slope of systolic upstroke between after and before the intervention(mmHg/ms) | 20 minutes | 
| changes of heart rate | the differences of heart rate between after and before the intervention (bpm) | 20 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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norepinephrine, dopamine