The Effect of Premedication on Postoperative Pain and Anxiety in Breast Cancer Surgery

Study Overview
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Brief Summary
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In this study, it was investigated whether the premedication drug administered before the surgery had an effect on postoperative pain and anxiety scores in female patients under the age of 65 who will undergo breast cancer surgery.

Detailed Description
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In this study, it was investigated whether the premedication drug administered before the surgery had an effect on postoperative pain and anxiety scores in female patients under the age of 65 who will undergo breast cancer surgery. The STAI-1(State Trait Anxiety İnventory ) form and APAIS (Amsterdam Preoperative Anxiety and İnformation Scale) scale were filled in for all preoperative patients. Afterwards, the patients were treated with either midazolam or dexmedetothymidine, depending on the anesthesiologist's preference. After administration, he was taken to surgery. As intraoperative analgesics, 2 mg/kg tramadol and 15 mg/kg paracetamol were administered to all patients. postoperative recovery time (aldrete 10), 1., 2.,6.,12.,24. VAS score, postoperative nausea-vomiting scale, STAI-1(State Trait Anxiety İnventory ) form, first need time if postoperative analgesic was needed, and 24-hour total analgesic consumption were recorded. It was aimed to examine the effects of different premedications on postoperative pain and anxiety

Official Title
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The Effect of Premedication Methods to be Applied to Prevent Preoperative Anxiety in Patients Who Will be Operated for Breast Cancer, on Postoperative Anxiety and Pain

Conditions
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Female Patients Under the Age of 65 Who Will Undergo Breast Cancer Surgery

Intervention / Treatment
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* Drug: Precedex and dormicum


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA 1-2-3 18-65 aged Female patients Exclusion Criteria: Under 18 years old and over 65 years old Having a history of cerebrovascular disease illiteracy Have visual and auditory problems İnability to cooperate with cognitive function test Having emergency surgery Those who are unable to read, understand and sign the consent form Patients deemed unsuitable by the investigator

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| low dose midazolam<br>0,025 mg/kg Midazolam | Drug: Precedex and dormicum<br>* Premedication<br>|
| high dose midazolam<br>0,05 mg/kg Midazolam | Drug: Precedex and dormicum<br>* Premedication<br>|
| low dose dexmedetothymidine<br>0.5 mg/kg dexmedetothymidine 10 minute infusion | Drug: Precedex and dormicum<br>* Premedication<br>|
| high dose dexmedetothymidine<br>1mg/kg dexmedetothymidine 10 minute infusion | Drug: Precedex and dormicum<br>* Premedication<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| effect of premedication on postoperative pain and anxiety scores |  | November 2022-December 2022 |