The Acute Effect of Grains of Paradise (Aframomum Melegueta) on REE

Study Overview
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Brief Summary
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Grains of paradise (Aframomumu melegueta) (GP), also known as Guinea pepper or Alligator pepper, belongs to the Zingiberaceae family, which is native to West Africa. GP seeds are used as a spice and also have wide-ranging ethnobotanical uses. GP seeds are very rich in non-volatile pungent compounds such as 6-paradol, 6-gingerol, 6-shogaol and related compounds. This feature may equip them with the power to activate the Sympathetic Nervous System and thereby increase EE, which has been demonstrated in rodents. Research suggest that ingestion of GP extract can result in sustained elevation of EE and a consequent reduction in body fat. Thus, there is some evidence that GP may have a potential thermogenic effect that could be useful as part of a weight loss treatment. However, there is no information on whether GP has the potential of improving and prolonging the thermogenic effects of bioactives known to elevate fatty acid mobilization and subsequent fat oxidation. This proposal will fill a void in the literature by testing for the first time in healthy, normal weight, human volunteers whether the ingestion of GP in combination with a commercially available complex containing caffeine, green tea, and forskolin has an enhanced acute effect on REE, the largest and most stable component of EE, as well as the ratio of fat:carbohydrate oxidation. This project will provide pilot data to support larger studies such as prospective studies and studies to compare the thermogenic effect with currently available compounds.

Official Title
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The Acute Effect of Grains of Paradise (Aframomum Melegueta) on Resting Energy Expenditure in Lean, Healthy, Adults

Conditions
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Obesity

Intervention / Treatment
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* Dietary Supplement: Grains of Paradise (Aframomum Melegueta)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Ages 18-65 years Men and women Able to provide written consent in English A body mass index between 18.5 and 30 kg/m2 Exclusion Criteria: Current smoker Claustrophobia Use of any prescribed or over-the-counter medication affecting metabolism Suffering from cardiac, hepatic, renal, pulmonary, endocrine or hematological disease Currently pregnant or breastfeeding Consuming more than 300mg of caffeine per day Consuming more than 2 alcoholic beverages per day. Performing more than 3 hrs/week of strenuous exercise Weight loss of more than 5% of body weight over the past 6 months Not willing to abstain from alcohol, caffeine and exercise for 24hr before each test day. Suffering from heartburn or a sensitivity to pungent compounds in foods

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Grains of Paradise<br> | Dietary Supplement: Grains of Paradise (Aframomum Melegueta)<br>* This is a randomized, double blind, crossover design testing the effect of grains of paradise on resting energy metabolism<br>|
| Placebo Comparator: Placebo<br> | Dietary Supplement: Grains of Paradise (Aframomum Melegueta)<br>* This is a randomized, double blind, crossover design testing the effect of grains of paradise on resting energy metabolism<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Resting metabolic Rate (Liters of oxygen consumed per minute) | Metabolic cart (metabolic gas exchange, indirect calorimitry) | 3 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Resting substrate oxidation | Metabolic cart (respiratory exchange ratio) | 3 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Grains of Paradise, energy metabolism, substrate oxidation