Hepatic Fibrosis Assessment Using Multiparametric Magnetic Resonance Imaging

Study Overview
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Brief Summary
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The purpose of this study is to assess degree of hepatic fibrosis using multiparametric MRI for investigating difference between normal or early fibrosis and advanced fibrosis.

Detailed Description
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In patients with liver parenchymal disease or normal liver parenchyma who are scheduled to undergo either liver resection or liver biopsy are included. Referred patients undergo multiparametric MRI including perfusion, diffusion, elastography and fat quantification before surgery or biopsy. The pathophysiologic changes are evaluated using multiparametric MRI, and compared between normal/early fibrosis and advanced fibrosis.

Official Title
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Hepatic Fibrosis Assessment Using Multiparametric Magnetic Resonance Imaging (MRI)

Conditions
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Fibrosis, Cirrhosis

Intervention / Treatment
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* Procedure: magnetic resonance imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients who are scheduled to undergo liver resection for focal liver lesion patients who are scheduled to undergo liver resection or percutaneous biopsy for diffuse parenchymal disease liver donor candidate who are scheduled to undergo preoperative liver biopsy or liver resection AND patients/living donor candidates who sign informed consent Exclusion Criteria: Patients who have at least one of followings are excluded. Patients who are contraindication for MRI contrast enhanced MRI. Premenopausal female patients who are pregnant. Patients who are physically compromised to acquire liver MRI

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Magnetic resonance imaging<br>multiparametric MRI including perfusion, diffusion, MR fat quantification and MR elastography | Procedure: magnetic resonance imaging<br>* multiparametric MRI as follows: diffusion weighted imaging using multiple b-values Fat quantification sequence perfusion MRI using ECCM agent MR elastography ------------------------------------ routine MRI using hepatocyte specific agent (optional in patients with focal liver lesion)<br>* Other names: MRI;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| difference of portal flow between no or early hepatic fibrosis and advanced hepatic fibrosis |  | in three years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| difference of arterial flow between no or early hepatic fibrosis and advanced hepatic fibrosis |  | in three years | 
| difference of liver stiffness value between no or early hepatic fibrosis and advanced fibrosis |  | in three years | 
| monitoring of transient dyspnea after contrast media injection |  | in three years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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fibrosis, cirrhosis, MRI