Comparison of Morphological and Radiological Data in Patients With Urolithiasis

Study Overview
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Brief Summary
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The aim of the study was to compare the ultrastructural changes in the renal parenchyma with the results of postprocessing CT analysis with contrast enhancement in patients with urolithiasis.

Official Title
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Comparison of the Morphological Picture of the Renal Parenchyma With the Results of Mathematical Analysis of Intrarenal Transport of Contrast Medium in Computed Tomography in Patients With Urolithiasis

Conditions
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Urolithiasis

Intervention / Treatment
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* Procedure: Percutaneous Nephrolithotomy
* Procedure: Partial nephrectomy
* Procedure: Radical nephrectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria for experimental group: Men and women >18 years and <45 years old; Established diagnosis of urolithiasis that does not interfere with the processes of urodynamics (there is no expansion of the overlying urinary tract); Planned surgery - percutaneous nephrolithotripsy; Stone size up to 20 mm., Patients with multiple small two-sided stones; Patients with CT of the kidneys with contrast enhancement performed according to the required protocol. Exclusion Criteria for experimental group: Age < 18 years old or ASA> 3; With single kidney; Patients with coral stones; The presence of concomitant systemic pathology (DM, AH), as well as kidney disease (glomerulonephritis), which can change the state of the renal parenchyma; A history of injuries and surgical interventions on the kidneys, urinary tract, renal vessels; Taking nephrotropic drugs; Systemic intake of nephrotoxic drugs; Severe general somatic condition, making the operation impossible; Pregnancy. Inclusion Criteria for control group: Men and women >18 years and <45 years old; Absence of urolithiasis in the patient's anamnesis and in his family history; Renal tumors which have undergone partial nephrectomy or nephrectomy; Patients with CT renal data with contrast enhancement, performed according to the required protocol. Exclusion Criteria for control group: Urolithiasis in anamnesis; A history of trauma and surgical interventions on the kidneys, urinary tract, renal vessels; Intercurrent background; Non-informative biopsy.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patients with urolithiasis<br>Patients with confirmed urolithiasis who is assigned to PCNL. | Procedure: Percutaneous Nephrolithotomy<br>* PCNL will be carried out in accordance with the standards and capabilities of the medical center. After the procedure pathomorphological data of the renal parenchyma will be assessed<br>|
| Active Comparator: Patients without urolithiasis<br>Patients with renal tumor without urolithiasis in history who is assigned to partial or radical nephrectomy due to renal tumor. | Procedure: Partial nephrectomy<br>* Partial nephrectomy will be carried out in accordance with the standards and capabilities of the medical center. After the procedure pathomorphological data of the renal parenchyma will be assessed<br>Procedure: Radical nephrectomy<br>* Nephrectomy will be carried out in accordance with the standards and capabilities of the medical center. After the procedure pathomorphological data of the renal parenchyma will be assessed<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To evaluate the features of interrenal transport of contrast agent and the structural state of the renal tissue | The data of 3D analysis of CT of the kidneys in patients with urolithiasis | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To assess the features of the morphological structure of glomeruli, tubules, perivascular and interstitial spaces of renal tissue in patients with urolithiasis | The assessment will be based on intraoperative biopsy | 2 weeks |