Diet and Disease Activity in Patients With Inflammatory Bowel Disease

Study Overview
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Brief Summary
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In addition to a genetic susceptibility, the immune system and the intestinal microbiota, diet is hypothesized to be an important factor in the onset and progression of Inflammatory Bowel Diseases (IBD). Further insight in factors affecting disease activity may contribute to targeted interventions improving disease burden and healthcare costs for these patients. However, well-designed studies exploring the role of diet in the development of exacerbations are hardly available. The investigators hypothesize that differences in dietary patterns affects the intestinal microbiota composition and thereby contributes to the development of exacerbations in IBD. Furthermore, a subgroup of patients suffers from malnutrition, although the exact prevalence is unknown since simple noninvasive screening tools have not been validated for IBD. The investigators hypothesize that malnutrition is frequently present in IBD patients and associated with dietary intake and disease characteristics.

Official Title
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Diet and Disease Activity in Patients With Inflammatory Bowel Disease

Conditions
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Inflammatory Bowel Disease

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: IBD patients, diagnosis based on clinical, endoscopic, histological and/or radiological criteria participating IBD-SL cohort Exclusion Criteria: Unable to provide informed consent

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| IBD-SL cohort<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The primary aim is to study the association of dietary patterns with disease activity in a consecutive cohort of IBD outpatients |  | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To characterize intestinal microbiota in IBD patients with different dietary patterns |  | 2 years | 
| To characterize the intestinal microbiota in IBD patients in remission developing an exacerbation during follow up |  | 2 years | 
| To investigate the stability of the intestinal microbiota in IBD patients remaining in remission during one year follow-up |  | 2 years | 
| To study the prevalence of malnutrition in a consecutive cohort of IBD outpatients | In a subpopulation of the present cohort (n=300) the nutritional status will be investigated | 1 year | 
| The study the association of disease characteristics and dietary intake with the prevalence of malnutrition in a consecutive cohort of IBD outpatients |  | 1 year | 
| To study the sensitivity and specificity of the SNAQ / MST as malnutrition screening tool in IBD outpatients based |  | 1 year |