A Study on the Inter-Hemispheric Alpha Ratio in Kids With ADHD (SHARK)

Study Overview
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Brief Summary
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Investigate the hypothesis that children with ADHD have difficulty with the allocation of visio-spatial attention related to an inability to control posterior alpha brain oscillations. A paradigm will be used in which the aim is to address covert attention as similar recent studies did in adults with ADHD.

Official Title
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Posterior Alpha Oscillations as an Index for the Attentional Bias in Children With Attentional Deficit Hyperactivity Disorder

Conditions
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ADHD

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: For both groups Age between 7 and 10 years of age. Estimated IQ above 80. Psychopharmaca- naïve or -free. For the ADHD-group - A diagnosis of ADHD, classified by the DSM-IV. Exclusion Criteria: (Co-morbid) psychiatric disorder (major depression, bipolar disorder, psychotic disorder, chronically motor tic disorder or Gilles de la Tourette, Conduct disorder, autism spectrum disorder, eating disorder, anxiety disorder). Neurological disorders (e.g. epilepsy) currently or in the past. Cardiovascular disease currently or in the past. Serious motor or perceptual handicap. For the no ADHD-group - No diagnosis of ADHD, classified by the DSM-IV.

Ages Eligible for Study
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Minimum Age: 84 Months
Maximum Age: 95 Months

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| ADHD<br>A diagnosis of ADHD, classified by the DSM-IV. | |
| no ADHD<br>No diagnosis of ADHD, classified by the DSM-IV. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Modualtion of alpha power | Modulation* of alpha power on congruent and incongruent trials of the covert attention task in 30 ADHD children and in 30 non-ADHD children *Modulation is the (expected) cue-induced change by a covert attention task. | Once for half an hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Response time on covert attention task | Time it takes to press the correct button after presentation of target-stimulus on congruent and incongruent trials of the covert attention task in 30 ADHD children and 30 non-ADHD children | Once for half an hour | 
| Standard deviation of response time on covert attention task | The variation of the time it takes to press the correct button after presentation of target-stimulus on congruent and incongruent trials of the covert attention task in 30 ADHD children and 30 non-ADHD children | Once for half an hour | 
| Correct responses on covert attention task | Number of correct button presses responses (i.e. same side as the target) on the covert attention task on congruent and incongruent trials of the covert attention task in 30 ADHD children and 30 non-ADHD children | Once for half an hour | 
| Mean deviation from middle on line bisection task | Mean deviation in mm from the center of the line on the line bisection task for 30 ADHD children and 30 non-ADHD children | Once in about 5 minutes | 
| Inattention score on the ADHD-RS-IV | The inattention subscale of the ADHD-RS-IV for 30 ADHD children and 30 non-ADHD children | Once in about 10 minutes | 
| Hyperactivity/impulsivity score on the ADHD-RS-IV | The hyperactivity/impulsivity subscale of the ADHD-RS-IV for 30 ADHD children and 30 non-ADHD children | Once in about 10 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Alpha, Lateralization, Attention, ADHD, Oscillation