Hepatic Blood Flow Changes During Fluid Challenge Assessed by MRI in Volunteers Subjects.

Study Overview
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Brief Summary
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Hepatic artery and portal flows are both regulated to assume the whole hepatic blood flow. Each counts for respectively 25% and 75%. That so-called buffer response assumes that when portal flow increases, hepatic artery flow decreases. During fluid challenge in intensive care unit, fluid challenge is often administered to improve hepatic perfusion. That observation is not demonstrated. The aim of the study is to test buffer response and portal flow during fluid challenge.

Detailed Description
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Prospective monocentric study at Amiens Hospital University. 20 volunteers subjects will be include after providing informed consent. Fluid challenge will be performed with 500 ml of intra venous NaCl (0.9%). Hepatic blood flow measurement will be performed using MRI.

Official Title
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Hepatic Blood Flow Changes During Fluid Challenge Assessed by MRI in Volunteers Subjects: a Prospective Monocentric Study. PORTEAU Trial

Conditions
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Hepatic Flow Changes

Intervention / Treatment
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* Device: MRI (magnetic resonance imaging)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Fasting for the last 12 hours. Exclusion Criteria: Claustrophobia Any previous medical history disease; Any abdominal surgical disease Pregnancy or breastfeeding

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: MRI (magnetic resonance imaging)<br>Hepatic blood flow baseline will be measured using MRI. Fluid challenge of 500 ml of NaCl 0.9% will be administered during 10 minutes. Before and After fluid challenge, MRI will be performed to compare flow changes. | Device: MRI (magnetic resonance imaging)<br>* Fluid challenge will be performed with 500 ml of intra venous NaCl (0.9%). Hepatic blood flow measurement will be performed using MRI.<br>* Other names: 500 ml of intra venous NaCl (0.9%).;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Portal blood flow measure before and after fluid challenge | Fluid challenge will be performed with 500 ml of intra venous NaCl (0.9%). Hepatic blood flow measurement will be performed using MRI (magnetic resonance imaging). | Two hours: the difference in hepatic portal flow before and after a volume expansion of 500 ml NaCl 0.9%. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hepatic artery blood flow measure before and after fluid challenge | Hepatic artery blood flow measure before and after a volume expansion of 500 ml NaCl 0.9%. | Two hours |