MOON Onsite MRI 10 Years After ACL Reconstruction

Study Overview
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Brief Summary
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In this study, a total of 219 subjects from the MOON nested cohort will be studied at CCF, Vanderbilt and OSU, Table 1. Among them, some will have added MRI during their 10-year visit for the MOON study. Some subjects who finished their 10-year visit for the MOON Onsite study already will be called back to have MRI. PROMs and other information of these subjects will be collected through the MOON study.

Detailed Description
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In this study, a total of 219 subjects from the MOON nested cohort will be studied at CCF, Vanderbilt and OSU, Table 1. Among them, some will have added MRI during their 10-year visit for the MOON study. Some subjects who finished their 10-year visit for the MOON Onsite study already will be called back to have MRI. PROMs and other information of these subjects will be collected through the MOON study. In addition, 30 age-, sex- and BMI-matched control subjects (10 from each site) will be recruited and scanned for MRI. PROMs (KOOS, IKDC, Marx, SF-36) will be collected from these controls. Among the 10 controls recruited locally at CCF, five will also travel to OSU and Vanderbilt to be scanned at the other two sites for cross-validation among the three sites. There will be a separate consent for the 5 controls that will be traveling to each of the 3 sites for the scans. The remaining 25 controls will be tested at only their local site.

Official Title
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Imaging Post-traumatic Osteoarthritis 10-years After ACL Reconstruction

Conditions
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Osteoarthritis, Knee

Intervention / Treatment
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* Other: No Intervention - Observational study with MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Enrolled in MOON Onsite Study 12-33 years old at baseline (22-45 years for this study); ACL tear during a sport; no previous knee injury; No graft rupture during follow-up; No history of surgery on the contralateral knee; No MRI contraindications Exclusion Criteria: History of surgery on contralateral knee Afraid of enclosed spaces

Ages Eligible for Study
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Minimum Age: 22 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients<br>Patients who had ACL reconstruction | Other: No Intervention - Observational study with MRI<br>* 90 minute MRI of the knees<br>|
| Controls<br>Controls who have no previous knee injury or surgery, no diagnosis of osteoarthritis | Other: No Intervention - Observational study with MRI<br>* 90 minute MRI of the knees<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cartilage health status | Quantitative MRI will be used to quantify cartilage health. Specifically, cartilage MR T1rho and T2 relaxation times will be quantified for cartilage of the knee that had ACL reconstruction, and compared to the contralateral uninjured knee. | At 10-years after ACL reconstruction | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient reported outcomes | Pain score (0-100) evaluated using Knee injury and Osteoarthritis Outcome Score (KOOS) | At 10-years after ACL reconstruction |