Single Lung Ventilation Versus Two Lung Ventilation

Study Overview
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Brief Summary
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Hypoxia in single lung ventilation versus two lung ventilation in video assisted lung surgeries

Detailed Description
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Incidence of hypoxia in single lung ventilation by double lumen endotracheal tube of choice in lung surgeries versus incidence of hypoxia in two lung ventilation by conventional single lumen endotracheal tube intermittent two lung ventilation

Official Title
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Single Lung Ventilation Versus Two Lung Ventilation in Video Assisted Lung Surgeries

Conditions
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Hypoxemia, Single Lung Ventilation

Intervention / Treatment
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* Procedure: Single lung ventilation by double lumen endotracheal tube
* Procedure: Two lung ventilation by conventional single lumen endotracheal tube


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age group: Adult patients from age of 21 years to 60 years Sex: Both sexes ASA Classification: patients with ASA classification II, III. Elective lung surgeries using video assisted thoracoscopic surgeries. Exclusion Criteria: Patients refuse to give informed consent. ASA Classification: ASA IV. Failure of thoracoscopic surgeries and continue as open thoracotomy Patients with ischemic heart diseases, where hypoxemia might be preexisting, or patient be more vulnerable to hypoxemia whatever the technique or time of hypoxia. Emergency lung surgeries. Patients underwent previous lung surgeries of any cause. Patients with pathology to the non-operated side.

Ages Eligible for Study
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Minimum Age: 21 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Two equal groups: the first group undergoing lung surgeries with single lung ventilation by double lumen endotracheal tube, the second group undergoing lung surgeries with two lung ventilation using conventional single lumen endotracheal tube
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Single lung ventilation<br>Using double lumen endotracheal tube and lung isolation | Procedure: Single lung ventilation by double lumen endotracheal tube<br>* Single lung ventilation using double lumen endotracheal tube and isolation of the operated lung during surgery to create ideal surgical field<br>|
| Active Comparator: Two lung ventilation<br>Using conventional single lumen endotracheal tube and intermittent two lung ventilation | Procedure: Two lung ventilation by conventional single lumen endotracheal tube<br>* Intermittent two lung ventilation so that no significant hypoxia occurs with creating optimum surgical field<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of hypoxemia | Hypoxemia in single and two lung ventilation by serial arterial blood gases | Intraoperative to first 24 hours post operative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of failure to correct Hypoxemia in single lung ventilation | Stop lung isolation and procedure using two lung ventilation to correct hypoxia | Intraoperative | 
| Incidence of failure of two lung ventilation to create optimum surgical field | Frequent stopping of ventilation and the surgent can't access the surgical field easily | Intraoperative | 
| Incidence of post operative complications | Any associated complications | First 24 hours post operative |