Dual PET/CT Imaging in Lung Cancer

Study Overview
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Brief Summary
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The purpose of this study is to compare conventional PET/CT scan performed 1 hour after injection of the radioactive tracer FDG (PET/CT[1]) with PET/CT performed after 3 hours (PET/CT[3]) in a group of patients with biopsy verified lung cancer or high suspicion of lung cancer after initial work-up (chest x-ray and CT of thorax/upper abdomen), who are potentially operable.

Detailed Description
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The investigators also want to: To find the sensitivity, specificity and accuracy in PET/CT 1h and 3 h in the staging of lung cancer (N-/M-stage). Our gold standard is pathology, when not possible - follow-up (se Gold Standard 6.1.1) To compare SUVmax with the expression of GLUT1 and G-6-Pase in tumors To compare the expression of GLUT1 with the activity of G6Pase To compare SUVmax, RI, tumor/liver ratio, GLUT1 and G-6-Pase with the occurrence of relapse within a year after curative surgery

Official Title
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Dual PET/CT Imaging in Lung Cancer (Danish Title: En og Tre Timers FDG-PET/CT Ved Lungecancer)

Conditions
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Lung Cancer

Intervention / Treatment
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* Other: Dual FDG-PET/CT


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Cytologic/histologic-verified lung cancer or high suspicion of lung cancer after initial work up Candidate to curative intended surgery after initial work up (usually chest x-ray, CT of chest/upper abdomen and if needed spirometry). Exclusion Criteria: Former lung cancer Contraindications for PET/CT: Pregnancy, recent chemoradiotherapy Diabetes mellitus.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| lung cancer or high suspicion of lung cancer<br>After initial work-up (chest x-ray, CT of thorax and upper abdomen, spirometry) found to have surgically resectable lung cancer | Other: Dual FDG-PET/CT<br>* Conventional FDG-PET/CT preformed after 1 hour and additional PET/CT 3 hours after injection<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sensitivity, specificity and accuracy | To find the sensitivity, specificity and accuracy in PET/CT 1h and 3 h in the staging of lung cancer (N-/M-stage). Our gold standard is pathology, when not possible - follow-up | After staging or 1 year of follow up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Occurence of relapse | • To compare SUVmax, RI, tumor/liver ratio, GLUT1 and G-6-Pase with the occurrence of relapse within a year after curative surgery | 1 year follow up after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Dual time PET/CT, glucose-6-phosphatase