linjc16/ctgov huggingface dataset:
Spontaneous Coronary Artery Dissection National Swiss Registry

Study Overview
=================
Brief Summary
-----------------
Spontaneous coronary artery dissection (SCAD), is an underdiagnosed pathology, affecting predominantly young women without traditional cardiovascular risk factors and is associated with major adverse outcomes including myocardial infarction, cardiac arrest, or death. Timely diagnosis of SCAD as well as clinical follow-up are of the essence in this pathology associated with major cardiac adverse outcomes. Despite recent improvements in diagnosis and recognition of the importance of SCAD, it remains poorly studied and understood. In this context, we designed the SwissSCAD registry, a large, observational, prospective, cohort study, to describe the natural history of SCAD, its outcomes and its treatments.

Official Title
-----------------
Spontaneous Coronary Artery Dissection (SCAD) National Swiss Registry (SwissSCAD)

Conditions
-----------------
Spontaneous Coronary Artery Dissection

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subject is ≥18 years of age. Patient presenting newly diagnosed SCAD or diagnosed with SCAD within the last 5 years. Subject must be willing to sign a Patient Informed Consent (PIC). Exclusion Criteria: Patient unwilling or unable to provide informed consent. Patients with atherosclerotic or iatrogenic coronary dissection.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Retrospective patients<br>The investigators will review the hospital records at the investigational site for SCAD events having occurred over the last 5 years. All SCAD patients aged ≥18 years, not presenting atherosclerotic or iatrogenic coronary dissection will be informed about the SwissSCAD study by phone and will be given at least one week to decide if they wish to participate. We plan to include 500 patients in the retrospective arm. | |
| Prospective patients<br>Patients presenting at the hospital with newly diagnosed SCAD will be informed of the SwissSCAD study and will be given at least one week to decide if they wish to participate. We plan to include 500 patients in the prospective arm. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of safety events at 30 days | Incidence of Major cardiovascular outcomes (MACE) at 30 days | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of safety events at 1 year | Incidence of Major cardiovascular outcomes (MACE) at 1 year | 1 year | 
| Incidence of safety events at 5 years | Incidence of Major cardiovascular outcomes (MACE) at 5 years | 5 years |
OLA to Lowest DP in Cardiac Surgery

Study Overview
=================
Brief Summary
-----------------
This study aims to compared the effects in driving pressure of an open-lung strategy with a positive end-expiratory pressure (PEEP) titrated to best driving pressure (DP) after a RM versus the recommended protective PEEP of 5 cmH2O without a recruitment manuever in non-obese patients undergoing cardiac surgery.

Official Title
-----------------
Open-lung Ventilatory Approach With Positive End-expiratory Pressure Titrated to Lowest Driving Pressure in Cardiac Surgery Patients

Conditions
-----------------
Lung Collapse

Intervention / Treatment
-----------------
* Procedure: DP-PEEP
* Procedure: RM-5


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Non-obese patients scheduled for cardiac surgery (CABG and valve replacement) Exclusion Criteria: i) age <18yr or >80yr, ii) pregnancy or breast-feeding status, and iii) patients with previous known respiratory disease, iv) Body mass index >35 kg/m2, v) emergency surgery and vi) hemodynamic instability at entry (need of vasopressors or ionotropes at entry or a ventricular assist device.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: DP-PEEP<br>recruitment maneuver + individualized PEEP | Procedure: DP-PEEP<br>* PEEP titration trial for the lowest DP after the alveolar recruitment maneuver<br>|
| Active Comparator: RM-5<br>recruitment maneuver + fixed standard PEEP | Procedure: RM-5<br>* Fixed standard PEEP after the alveolar recruitment maneuver<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| driving pressure | The driving pressure is a physiological ventilatory parameter measured as platteau pressure minus PEEP. This parameter may be associated with postoperative pulmonary complications | intraoperative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative pulmonary complications | The most frequent postoperative pulmonary complications will be recorded (acute respiratory failure, pneumonia, atelectasis, need of ventilatory support, acute respiratory distress syndrome) | 72 first postoperative hours |
Outcomes of Children With Congenital Single Ventricle Heart

Study Overview
=================
Brief Summary
-----------------
Congenital heart disease affects 1 in 100 newborn babies each year and more than 2,000,000 Americans have a congenital heart defect. One common defect treated at Children's Healthcare of Atlanta at Egleston is single ventricle heart. Due to these overwhelming numbers, the use of diagnostic imaging technology to assess these defects and heart function is an important step in the evolving care of this patient group.

Detailed Description
-----------------
The definition of single ventricle can mean a ventricle that is hypoplastic, too small, or completely absent. Either the right or left ventricle may be affected. There may also be other cardiac anomalies present. Infants with a single ventricle develop distress after birth when the ductus arteriosus and foramen ovale close. This may happen within hours or days of delivery. The severity of symptoms is determined by the degree of defect. But, single ventricle patients will not survive without treatment. Patients with only one functioning ventricle can usually expect either a heart transplant or a series of palliative surgeries or sometimes both. Their care is very complex requiring a team of dedicated practitioners to manage drug therapy, medical support and surgery. At Children's Healthcare of Atlanta at Egleston, it is standard of care for a patient with a single ventricle heart to undergo many non-invasive imaging studies and sometimes invasive studies such as heart catheterization. Results of the studies provide valuable information used for treatment decisions and evaluation of heart function. We propose to do a retrospective chart review of patient data including a review of their invasive and non-invasive studies.

Official Title
-----------------
Assessment of the Outcomes of Children With Congenital Single Ventricle Heart

Conditions
-----------------
Congenital Disorders

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Single Ventrical heart Exclusion Criteria: those patients who do not have single ventrical heart

Ages Eligible for Study
-----------------
Maximum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| We propose to do a retrospective chart review of patient data including a review of their invasive and non-invasive studies. | We propose to do a retrospective chart review of patient data including a review of their invasive and non-invasive studies. | 13 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
pediatric, cardiac, single ventricle
Description and Evaluation of Eating Disorders in Elite Athletes (TCA SHN)

Study Overview
=================
Brief Summary
-----------------
Athletes in particular elite athletes have obsessional food and body concerns, in bond with a worship of the performance more and more invading, which lead to clinical and subclinical eating disorders. These eating disorders differ according to the disciplines and are difficult to diagnose in athletes because there are insufficiently described. Our aim at estimating the frequency of eating disorders in athletes and describing eating disorders by means of somatic, dietetic and psychological evaluations.

Official Title
-----------------
Description and Evaluation of Eating Disorders in Elite Athletes

Conditions
-----------------
Eating Disorders, Anorexia Nervosa, Boulimia Nervosa, Binge Eating Disorders

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: to have at least 12 years to be registered on the high level sportsmen list or to be in access to high level sport to have obtained the non opposition of the athlete if he is major (if not the legal person in charge of the athlete have to give is non opposition). to be affiliated to social security Exclusion Criteria: presenting obvious cognitive disturbance not able to understand or/ and to read French language pregnant women subject under tutelage

Ages Eligible for Study
-----------------
Minimum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Presence of eating disorder | A subject presents an eating disorder if at least one of the tree clinical investigators (somatician, dietician, psychologist) mark it. Eating disorders will be described by: Dietetic consultation, Somatic examination, Psychological evaluation | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Presence of eating disorder according to the psychologist, dietician and the somatician | Presence of eating disorder according to the psychologist, dietician and the somatician | 1 day | 
| Sociodemographic variables | age, sex, sporting discipline exercised | 1 day | 
| Doping conduits variables | age of onset of consumption (PAP support products performance) legal and illegal, current frequency of consumption of PAP licit and illicit consumption as problematic or not the patient. | 1 day | 
| Investment in practice sporting variables | Desired level of sports, number of hours per week over the last 4 weeks, up / concern of the sport. | 1 day | 
| Addictives and psychiatric comorbidity | anxiety disorders, depression and sleep disorders Scale : GEEMS, EDI, EDS-R | 1 day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
reverse anorexia,, anorexia athletics
COVID 19 Serology in Pulmonologists

Study Overview
=================
Brief Summary
-----------------
Respiratory physicians are highly exposed workers to Covid-19 as they perform spirometry, endoscopy, and manage Covid-19 in first line for most of them. Moreover, none reported to have apply increased levels of protection for performing these acts in the most active period of viral circulation, until the lockdown. Whether they were most frequently immunized against SARS-CoV-2 at the end of the first wave than the general population is of utmost importance individually but also worldwide

Official Title
-----------------
COVID 19 Serology in Pulmonologists : Pneumo Sero Cov

Conditions
-----------------
Covid 19

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pulmonologists of Languedoc Roussillon Actively working Registered Exclusion Criteria: refusal to participate

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| covid 19 serology | covid 19 serology with cross sectional | 1 day | 
| risk factors for positive serology testing | risk factors for positive serology testing with cross sectional | 1 day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Covid 19, serology
Food and the Brain

Study Overview
=================
Brief Summary
-----------------
The proposed study will examine the role of reward and emotion in women with and without a history of binge eating. It is important to understand how the brain responds to reward and emotion in binge eating in order to identify different pathways toward binge eating and provide individualized targets for treatment. This is particularly important in light of the fact that for many patients, the current treatments for binge eating are not effective.

Official Title
-----------------
Emotion and Reward Processing in Binge Eating

Conditions
-----------------
Binge Eating

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Female Ages 18-35 with or without current binge eating behaviors Exclusion Criteria: Any contraindication for MRI (orthodontia, vascular stents, metallic ear tubes, metal implants, piercings, etc). substance abuse traumatic brain injury BMI < 18.5 pregnant women

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Women ages 18-35<br>Women ages 18-35 who do and do not engage in binge eating will be included in the study | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Brain activity during rest | Functional magnetic resonance imaging will be used to measure brain activity at rest and connectivity between brain regions will be examined. | Baseline | 
| Brain activity during emotion conflict | Functional magnetic resonance imaging will be used to measure brain activity during a task where participants respond to images of faces with emotional expressions overlaid with an emotion word written in text. We will focus on brain response during this task when emotion face vs word are in conflict. | Baseline | 
| Brain activity during monetary wins and losses | Functional magnetic resonance imaging will be used to measure brain activity during a game where participants can win or lose money if they respond to a shape on the computer screen. Brain response during wins and losses will be examined. | Baseline | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
fMRI, emotion conflict task, monetary incentive delay
Preoperative Breast Irradiation

Study Overview
=================
Brief Summary
-----------------
The PROBI is a phase I/II trial assessing the feasibility of preoperative whole breast irradiation in female patients with low to intermediate risk breast cancer, who undergo breast conserving therapy, including a boost dose of irradiation. An additional goal of this study is to assess tumor response to radiotherapy, by imaging modalities (PET-CT and MRI) and pathology

Official Title
-----------------
Preoperative Breast Irradiation, the PROBI Trial. A Phase I/II Feasibility Trial

Conditions
-----------------
Breast Cancer

Intervention / Treatment
-----------------
* Radiation: pre-operative irradiation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Histologically proven invasive breast carcinoma cT1-2N0 breast cancer cM0 female patients ≤ 50 years planned breast conserving surgery ability to undergo irradiation and surgery signed written informed consent Exclusion Criteria: prior surgery or radiotherapy for the protocol tumor (neoadjuvant chemotherapy or endocrine therapy is allowed) planned oncoplastic reduction mammoplasty cTis extensive calcifications on mammagram (Birads 3,4 or 5) cT3-4 and/or cN1-3 invasive carcinoma distant metastasis

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: radiation<br>intervention: pre-operative breast irradiation of 21 fx of 2.2Gy and boost 2.66Gy | Radiation: pre-operative irradiation<br>* pre-operative whole breast irradiation of 21 fx of 2.2Gy and boost of 2.66Gy<br>* Other names: radiotherapy;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative surgical complications | postoperative complication will be scored by a specific list | within six weeks after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Radiological response | assessed by MRI | 6 weeks post-radiation | 
| Pathological response | surgery specimen | at surgery | 
| cosmetic outcome | cosmesis will be scored by physician by questionnaire and cosmesis will be cored by patient by questionnaire | 1,3 and 5 years post-treatment | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
pre-operative radiotherapy
Alzheimer's Disease and Aging: Therapeutic Potential of Estrogen

Study Overview
=================
Brief Summary
-----------------
This study is designed to evaluate the potential beneficial effects of estrogen on cognitive function of women with Alzheimer's Disease.

Official Title
-----------------
Alzheimer's Disease and Aging: Therapeutic Potential of Estrogen

Conditions
-----------------
Alzheimer's Disease

Intervention / Treatment
-----------------
* Drug: estrogen


Participation Criteria
=================
Eligibility Criteria
-----------------
Post menopausal women with alzheimer's disease free of any major medical or neurological disease, medically safe to be treated with estrogen.

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: estrogen|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Electroencephalogram (EEG) Triggered Functional Magnetic Resonance Imaging (fMRI) in Epilepsy Patients

Study Overview
=================
Brief Summary
-----------------
A prospective exploratory study in patients with drug resistant epilepsy with a target comparison of long term outcome. NeuroScan software modules and a MagLink will be used to acquire EEG in combination with MRI/fMRI data. The MagLink system is used for obtaining integrated EEG and Event Related Potential (ERP) recordings while the subject is inside the MRI machine, without compromising the raw EEG data.

Official Title
-----------------
EEG-triggered fMRI in Epilepsy Patients

Conditions
-----------------
Epilepsy

Intervention / Treatment
-----------------
* Other: EEG Triggered fMRI using Micro Maglink


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Refractory epilepsy cases, referred by the service of Neurology. These are cases whose pathophysiology is resistant to treatment, including change in medication and or added medication. Patients will be included if they agree to sign an Institutional Review Board approved written consent. Exclusion Criteria: Patients with overt symptoms or signs of anxiety than cannot cooperate during the recording inside the scanner, unless consent is given for the procedure to be performed with sedation by the anesthesia department. Patients who meet the regular exclusion criteria for Magnetic Resonance Imaging (MRI) studies per the prescreening form reviewed with all patients prior to exams

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: EEG Triggered fMRI using Micro Maglink<br>EEG Triggered fMRI to be performed using the Micro Maglink | Other: EEG Triggered fMRI using Micro Maglink<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of participants with at least 40 interictal epileptic discharges during the fMRI |  | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
intractable, EEG triggered, fMRI, epilepsy