Narrow Band Imaging for Diagnosis of Proximal Serrated Polyps

Study Overview
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Brief Summary
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Although colonoscopy is considered the gold standard for diagnosis of colonic polyps, the missed rate for colonic adenoma ranged from 15-32%. In particular, missed colonic polyps in the right side colon have been suggested to be the cause for interval cancer that developed after a prior negative colonoscopy. Different endoscopic image enhanced modules like the narrow band imaging (NBI) have been developed to improve colonic polyp detection. However, it remains controversial whether the previous version of NBI helps to improve colonic polyp detection. The new generation colonoscope is equipped with high definition and improved narrow band imaging (NBI) which gives at least twice the viewable distance and contrast. The images obtained are far brighter with better resolution than the previous version. It however remains to be determined whether this enhanced imaging technique could help to improve colonic polyps detection. Hypothesis: The new generation NBI increases the detection rate of proximal serrated polyps and reduces the missed rate of all colorectal polyps. Aims: To determine whether the new generation NBI improve the detection rate of proximal serrated polyps. To determine whether the new generation NBI improve the detection rate of all colorectal adenoma and polyps. To determine whether the new generation NBI reduce the miss rate of colorectal adenoma and polyps.

Detailed Description
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Design: Prospective randomized trial Inclusion: • All patients scheduled to have screening or scheduled colonoscopy Exclusion: History of Crohn's or ulcerative colitis Surveillance for known polyposis syndrome (FAP or HNPCC) Previous colonic resection (except appendectomy) Refused consent Deranged coagulation profile that preclude polypectomy

Official Title
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Colonoscopy With Narrow Band Imaging for Diagnosis of Proximal Serrated Polyps

Conditions
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Colonic Neoplasm

Intervention / Treatment
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* Other: Narrow band imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients scheduled to have colonoscopy Exclusion Criteria: History of Crohn's or ulcerative colitis Surveillance for known polyposis syndrome (FAP or HNPCC) Previous colonic resection (except appendectomy) Refused consent Deranged coagulation profile that preclude polypectomy

Ages Eligible for Study
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Minimum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Narrow band imaging<br>Colonoscopy with new narrow band imaging | Other: Narrow band imaging<br>* Colonoscopy with new narrow band imaging<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Detection rate of proximal serrated polyp | No. of patients with proximal serrated polyps | During colonoscopy | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Missed rate for proximal serrated polyps | Missing rate for proximal serrated polyps | During colonoscopy | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Colonoscopy, colonic adenoma, serrated polyps