Cardiac Output and Recovery Time

Study Overview
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Brief Summary
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The purpose of this research is to determine the time it takes to reverse the effects of the intraoperative medication given to relax the muscles and how this period of recovery correlates with a function of the heart.

Official Title
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Correlation Between Cardiac Output and Recovery Time After Reversal of Rocuronium-Induced Blockade With Sugammadex

Conditions
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Residual Neuromuscular Blockade

Intervention / Treatment
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* Device: TetraGraph


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age > or = 18 years old. Patients willing to participate and provide an informed consent. Patients undergoing an elective surgical procedure requiring administration of rocuronium, and the use of a pulmonary artery catheter intraoperatively. Exclusion Criteria: Patients with unilateral disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture. Patients with systemic neuromuscular diseases such as myasthenia gravis. Patients with significant organ dysfunction that can significantly affect pharmacokinetics of neuromuscular blocking and reversal agents, i.e., severe renal impairment or end-stage liver disease. Patients having surgery that would involve prepping the arm or leg into the sterile field.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: TetraGraph monitoring<br>Subject scheduled to undergo an elective surgical procedure will have TetraGraph device lead placement on either hand at a discretion of the anesthesiologist | Device: TetraGraph<br>* FDA approved neuromuscular transmission monitor capable of measuring the depth of neuromuscular block in anesthetized patients who received neuromuscular blocking agents. TetraGraph uses EMG to measure the muscle action potentials that are generated in response to electrical neurostimulation via skin electrodes.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recovery time after administration of sugammadex and its correlation to cardiac output measure | Change in cardiac output measurement after reversal with sugammadex as compared to the time it takes to recover from the rocuronium-induced blockade. | Up to 1 hour postoperative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation of speed of recovery from neuromuscular blockade and age. | Change in the speed of recovery from neuromuscular blockade as compared to participant's age. | Up to 1 hour postoperative | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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EMG, Neuromuscular Blockade, Tetragraph, AMG