Basic Auditory Processing and Auditory Hallucinations

Study Overview
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Brief Summary
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Schizophrenia is a severe psychiatric disorder that affects approximately 1% of the population worldwide. Although pathophysiology of this disease remains unclear, a growing interest is emerging for low-level sensory function, acknowledging that deficits in early stages of sensory processing are related to higher-order cognitive disturbances in schizophrenia. In the field of auditory processing, symptoms as auditory-hallucinations were found correlated with disabilities to discriminate psychoacoustic parameters of sounds.

Detailed Description
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Outcomes: Our main hypothesis is that Auditory Hallucinations Rating Scale (AHRS) scores are correlated with the percentage of wrong answers in a Tone-Matching Task test. The main objective is to assess this correlation. Our other objectives are to assess correlation between AHRS as well as other symptoms scales and psychoacoustic tests assessing intensity, length discrimination of non-verbal tones and self-monitoring abilities. Impact of therapeutic procedures (neuromodulation, psychotherapy) conducted independently of our study on these psychoacoustic tests will also be assessed. Methods: 30 subjects with schizophrenia will be included. Clinical and psychoacoustic measures will be carried out at J-0. In the case of patients receiving therapeutic procedures independently of our study, new clinical and psychoacoustic measures will be carried out at J+7 and J+30.

Official Title
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Basic Auditory Processing and Acoustico-verbal Hallucinations: a Pathophysiological Study

Conditions
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Schizophrenia

Intervention / Treatment
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* Other: Clinical and psychoacoustic measures


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age from 18 to 65 years old Meeting DSM-5.0 criteria for schizophrenia Auditory Hallucinations Rating Scale ≥ 8 Negative βHCG level if woman Effective contraception if woman Consent to be included in the study Exclusion Criteria: Hearing impairment Neurologic disorder Other psychiatric disorder from the DSM-5.0 section II Developed musical abilities (regular practice of singing or a musical instrument) Pregnancy Does not consent to be included in the study Lacking in legal capacity

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 30 patients with schizophrenia<br>Measure the correlation between the score on the scale psychometric AHRS (Auditory Hallucination Rating Scale) to measure HAV and performance scores discrimination test psychoacoustic Tone Matching Task in subjects suffering from schizophrenia and HAV. | Other: Clinical and psychoacoustic measures<br>* Our study focuses on psychoacoustic tests, specialist care protocols (psychotherapy, neuromodulation ...) being made independently of our study, as part of medical activity of Cerletti care unit or differentiated protocols. Thus, our study shows no individual benefit for the patient. However, a better understanding of the neurophysiological mechanisms underlying auditory hallucinatory phenomenon could allow a better management of these patients in the near future<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| percentage error in discrimination test psychoacoustic Tone Matching Task | Our main hypothesis is that Auditory Hallucinations Rating Scale (AHRS) scores are correlated with the percentage of wrong answers in a Tone-Matching Task test. | immediately after treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Score the item hallucinations of psychometric ( positive and negative syndrome ) scale | Rating Scale(AHRS) as well as other symptoms scales and psychoacoustic tests assessing intensity, length discrimination of non-verbal tones and self-monitoring abilities. | immediately after treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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auditory processing disorders, auditory perception, pitch discrimination, auditory-verbal hallucinations, theory of mind