Comprehensive Risk Assessment of People With Silicosis: A Population-based Study

Study Overview
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Brief Summary
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Objectives: This study aims to explore the risk profiles among people with silicosis in Hong Kong underpinned by the Pittsburgh Mind-Body Center model. Design and subjects: This study will adopt a cross-sectional study design with sampling stratified by participants' degree of incapability. 320 Chinese people diagnosed with silicosis and registered with the Pneumoconiosis Compensation Fund Board will be recruited. Data collection: A demographic data sheet and the St. George's Respiratory Questionnaire will be used to collect the socio-demographic and clinical characteristics of the participants. The behavioral factors (smoking, drinking, physical activity level, consumption of vegetable and fruits and plasma vitamin C level) as well as the psychological risk factors (anxiety and depressive symptoms, and social support) will be examined by validated questionnaires. Biological and physiological parameters, including insulin resistance, C-reactive protein, hemoglobin, fasting blood glucose and lipid profiles, will be ascertained by fasting blood sample. Data analysis and expected outcomes: The findings of this study will create the database profile of the physical, psychosocial and disease specific aspects among people with silicosis in Hong Kong, subsequently forming the empirical basis of an intervention to tackle the identified modifiable risks among them.

Official Title
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Comprehensive Risk Assessment of People With Silicosis: A Population-based Study

Conditions
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Silicosis

Intervention / Treatment
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* Other: People with silicosis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Hong Kong Chinese-speaking residents and Chinese ethnicity; diagnosis of silicosis and confirmed by the Pneumoconiosis Medical Board registered with the Pneumoconiosis Compensation Fund Board (PCFB); and able and willing to give informed written consent Exclusion Criteria: With medically diagnosed mental illness, including major depression, or with active pulmonary tuberculosis

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| people with silicosis<br> | Other: People with silicosis<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Respiratory symptoms and related physical limitation | examined by Hong Kong Chinese version of St. George's Respiratory Questionnaire | baseline | 
| Psychological status | Anxiety and depression symptoms measured by the Chinese version of Hospital Anxiety and Depression Scale | baseline | 
| Quality of life | examined by the SF-12v2 | baseline | 
| Social support | measured by the Chinese version of six-item Social Support Questionnaire | baseline | 
| Body mass index | BMI in kg/m^2 | baseline | 
| waist circumference | WC in cm | baseline | 
| 12-hour fasting lipid profile | total-cholesterol, HDL-Cholesterol, LDL-cholesterol and triglycerides (in mmol/L) | baseline | 
| 12-hour fasting glucose | FG in mmol/L | baseline | 
| fasting insulin level | insulin in pmol/L | baseline | 
| 12 hour fasting ascorbic acid level | vit-C in mg/dL | baseline | 
| fasting high sensitivity C-reactive protein level | hs-CRP in mg/L | baseline | 
| hemoglobin level | hemoglobin in g/dL | baseline | 
| smoking and drinking habits, vegetable and fruit intake | questions adopted from the Behavioral Risk Factor Surveillance of the Department of Health, Hong Kong SAR | baseline | 
| Physical activity level | measured by the International Physical Activity Questionnaire - Short Form | baseline |