Melatonin and Coronary Artery Calcification

Study Overview
=================
Brief Summary
-----------------
The investigators planned to research the association between plasma melatonin and coronary artery calcification in a Chinese population.

Detailed Description
-----------------
Coronary artery calcification (CAC) is prevalent in coronary artery disease (CHD), and the extent of CAC predicts cardiovascular risk. The causes of CAC include dysregulated matrix metabolism, epitaxial mineral deposition, inflammation, oxidative stress, and apoptosis. Melatonin is the main indoleamine produced by the pineal gland; it is known recently to have anti-inflammatory, anti-cancer and antioxidant activities. Several studies have shown that melatonin protects against inflammation and apoptosis in vascular calcification. Melatonin also inhibits oxidative stress-induced apoptosis and calcification in endplate chondrocytes. However, no study has evaluated whether melatonin is associated with CAC in patients with coronary atherosclerosis. The investigators planned to research the association between plasma melatonin and coronary artery calcification.

Official Title
-----------------
Association Between Plasma Melatonin and Coronary Artery Calcification

Conditions
-----------------
Coronary Artery Calcification

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with angina-like chest pain, were included in this study. All subjects had blood samples collected and all underwent a coronary CTA scan. Exclusion Criteria: melatonin treatment coronary revascularization (percutaneous coronary intervention or coronary artery bypass graft surgery) heart failure or cardiomyopathies hepatic failure renal dysfunction haemolytic disorders thyroid disease neoplastic diseases acute infectious or inflammatory conditions.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| plasma melatonin 1<br>Quartile 1 of plasma melatonin | |
| plasma melatonin 2<br>Quartile 2 of plasma melatonin | |
| plasma melatonin 3<br>Quartile 3 of plasma melatonin | |
| plasma melatonin 4<br>Quartile 4 of plasma melatonin | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| correlations of CAC score with melatonin concentrations | CAC score was obtained using the coronary CTA and Agatston score. | Subjects underwent a CAC scan at baseline. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| correlations of CAC score with high-sensitivity C-reactive protein (hsCRP) level | The hsCRP levels were analyzed by a sandwich enzyme linked immunosorbent assay. | Subjects had blood samples collected at baseline. | 
| correlations of CAC score with malondialdehyde (MDA) level | The MDA levels were analyzed by a sandwich enzyme linked immunosorbent assay. | Subjects had blood samples collected at baseline. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Melatonin, coronary artery calcification, relation