Hospitalisations of Teenagers and Young Adulthoods in Mayotte After Consumption of an Illegal Drug Called  Chimique , Which Substances Are Incriminated ? : HOMACHI

Study Overview
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Brief Summary
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The study aims (i) to identify which substances leading to hospitalizations at Mayotte are also called chimique and (ii) to correlate these substances with clinical pictures in order to favor a better approach of the treatments.

Detailed Description
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The CEIP-A of Bordeaux (in charge of French overseas departments) has been commissioned by the MILD&CA in 2015 to reinforce the links between local caregivers and the addictoviligance's inquieries. In particular, the CEIP-A has been alerted about a drug called  chimique  in Mayotte, leading to many hospitalizations. Most of the patients are less than 18 year old or are young adulthoods. For all patients who have agreed to participate in this study, the remainder of the blood sample will be reused for a drop of blood on blotting paper; the remainder of the remainder will be stored in the heparinized tube. Medical data collected in the emergency department will also be collected. All the data will be analyzed by the pharmacology and toxicology laboratory of the Bordeaux University Hospital

Official Title
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Hospitalisations of Teenagers and Young Adulthoods in Mayotte After Consumption of an Illegal Drug Called  Chimique , Which Substances Are Incriminated ? : HOMACHI

Conditions
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Drug Abuse

Intervention / Treatment
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* Other: targeted high-resolution mass spectrometry


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients hospitalized in the Emergency Department of the Mayotte Hospital Center after taking a chemical or other psychoactive substance and for whom a blood test is required; Age ≥ 14 years. Exclusion Criteria: Patient without parental authority for minor patients aged 14yrs; Patient not included in the exception article 59 of the law of January 6th, 1978 modified for patient aged 15yrs and older

Ages Eligible for Study
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Minimum Age: 14 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Adult<br>Patients aged 18yrs and older hospitalized in the Emergency Department of the Mayotte Hospital Center after taking a chemical or other psychoactive substance and for whom a blood test is required | Other: targeted high-resolution mass spectrometry<br>* difference between the number of new substances identified using targeted analysis by liquid chromatography coupled with high-resolution mass spectrometry versus using targeted analysis. narcotics-new substance by liquid chromatography coupled with tandem mass spectrometry<br>|
| Minor<br>Patients aged 14-17yrs and older hospitalized in the Emergency Department of the Mayotte Hospital Center after taking a chemical or other psychoactive substance and for whom a blood test is required | Other: targeted high-resolution mass spectrometry<br>* difference between the number of new substances identified using targeted analysis by liquid chromatography coupled with high-resolution mass spectrometry versus using targeted analysis. narcotics-new substance by liquid chromatography coupled with tandem mass spectrometry<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of new substances identified | number of new substances identified | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Active ingredients found | Number of active ingredients found (including new substances | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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drug abuse, chimique, High resolution mass spectrometry