linjc16/ctgov huggingface dataset:
An Explorative Study To Develop A Predictive Model Based On Avascular Exposed Root Surface Area For Root Coverage

Study Overview
=================
Brief Summary
-----------------
The aim of this study was to evaluate the reliability of the avascular root surface area as a prognostic identification criterion for gingival recessions and to compare the predictive value of the Miller classification and avascular root surface area (AERSA) calculation on the final root coverage outcomes.

Conditions
-----------------
Gingival Recession

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Presence of isolated Miller I, II or III recession, (Miller 1985a) Presence of identifiable cementoenamel junction (CEJ); presence of a step ≤ 2mm at CEJ level and/or the presence of a root abrasion, but with an identifiable CEJ, Full-mouth plaque score and Full-mouth bleeding score of < 15% (four sites/tooth), No occlusal interferences; Non-smokers Exclusion Criteria: Tooth with a prosthetic restoration involving CEJ, Patients with a history of periodontitis or abscess formation, Presence of systemic disease or taking medications known to interfere with periodontal tissue health Pregnant or nursing patients

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 41 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| AERSA-I gingival recession<br>The AERSA classification was developed based on 15 mm2 which is the lowest cut-off point and the group of AERSA ≤ 15 mm2 named as AERSA-I (low risk group) | |
| AERSA-II gingival recession<br>AERSA > 15 mm2 named as AERSA-II (high risk group). | |
| Miller gingival recession<br>Gingival recessions classified according to Miller | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complete root coverage |  | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mean root coverage |  | 6 months |
Opioid-Free Anesthesia in Modified Radical Mastectomy

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to evaluate the efficacy of opioid-free general anesthesia for breast surgeries in female patients.

Official Title
-----------------
Efficacy of Opioid-Free Anesthesia in Modified Radical Mastectomy

Conditions
-----------------
Surgery, Anesthesia, Opioid Use

Intervention / Treatment
-----------------
* Procedure: opioid anesthesia


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients underwenting modified radical mastectomy Undergoing general anesthesia Exclusion Criteria: Patients were excluded if they had Alzheimer's Disease, mental retardation, failure of locoregional anesthesia, contraindication for locoregional anesthesia.
Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1 consisting of treated patients using OFA<br>Group 1 consisted of 56 (Mean age was 54±14 years) | |
| Group 2 consisting of treated patients using NOFA<br>Group 2 consisted of 60 patients (Mean age was 51±12 years) | Procedure: opioid anesthesia<br>* opioid-free general anesthesia vs non opioid-free general anesthesia<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Post operative Morphone use | Patients who received Morphine at different time points in function of the two study groups | up to 24 hours | 
| Time To Extubation (TTE) | Time to Extubation in function of the two study groups | Directly intraOp | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Post Operative Nausea and Vomiting (PONV) | Patients who had PONV at different times in function of the two study groups | Up to 24hours |
A Network Intervention for Prevention of HIV Infection in Chennai, India - 1

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate a peer-based HIV prevention intervention that targets active injection drug users and their drug and sex partners in Chennai India.

Detailed Description
-----------------
The intervention to be tested in this study draws upon theoretical and empirical evidence suggesting that peer educator programs can have significant effects on the risk-related behaviors of both the educators and the peers whom they educate. Specifically, through group and individual focused sessions, participants learn and practice skills designed to reduce drug and sex related risk behaviors. Furthermore, individuals and their main risk partners attend a training session that focuses on risk reduction within their relationship.

Official Title
-----------------
Supplement to the Long-term Impact of a Network Outreach Intervention

Conditions
-----------------
HIV Infections

Intervention / Treatment
-----------------
* Behavioral: psychoeducational
* Behavioral: control


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: drug users network members

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>behavioral social network risk reduction intervention | Behavioral: psychoeducational<br>* psychoeducational<br>|
| Active Comparator: 2<br>voluntary counseling and testing (VCT | Behavioral: control<br>* VTC<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| needle sharing |  | 3 month | 
| condom use |  | 3 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
injection drug use, social networks, HIV
Growth Hormone Treatment in Children Born Small for Gestational Age: Assessment of Satisfaction

Study Overview
=================
Brief Summary
-----------------
This trial is conducted in Europe. The aim of this trial is to assess satisfaction with growth hormone treatment in children of both sexes born small for gestational age and who are receiving growth hormone treatment.

Official Title
-----------------
Assessment of Satisfaction With Growth Hormone Treatment in Children Born Small for Gestational Age: Benefits of Galenic Form of the Product

Conditions
-----------------
Foetal Growth Problem, Small for Gestational Age

Intervention / Treatment
-----------------
* Drug: somatropin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children treated for 3 years with Maxomat® because of small for gestational age Postnatal growth failure by the age of 3 years or more No associated growth hormone deficiency Height growth velocity greater than 2 cm/yr over the 12 month period preceding the inclusion Bone age no more than 13 years for girls and no more than 15 years for boys Exclusion Criteria: Known, evolving tumour Hypertrophic cardiomyopathy Hypertension not controlled on maximum therapy Benign intracranial hypertension Known glucose intolerance or known diabetes mellitus Acute or active chronic hepatitis Chronic renal failure Chromosomal and/or genetic syndromes (other than Silver-Russell syndrome) or abnormality

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 15 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: somatropin|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Satisfaction/preference with the method of treatment assesses by means of a satisfaction questionnaire and a standard questionnaire of preference |  | after 3 months of treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical (adverse events) |  |  | 
| Biological (fasting glucose, fasting insulin, liver enzymes) |  |  | 
| Tolerance of the treatment |  |  | 
| Compliance |  |  |
Home Based Resistance Training For Type 2 Diabetes

Study Overview
=================
Brief Summary
-----------------
This study will investigate the biological and psychosocial benefits of a home-based resistance-training program for sedentary, obese adults living with type 2 diabetes.

Detailed Description
-----------------
Obese individuals with type 2 diabetes will be randomly assigned to either an experimental group where they will perform moderate to high intensity resistance training (50-60% 1RM weeks 1-3 and 70-85% 1RM in weeks 4-16) three times per week for 16 weeks or to a non-training control group. All resistance training will be performed at home using a multigym apparatus. A personal trainer (PT) will come to the homes of each participant in the experimental group to make sure that exercises are being performed safely with the correct technique, and at the prescribed intensity. In the first two weeks, the PT will come to all 3 sessions per week. In weeks 3-4 this will be reduced to 2 times per week, in weeks 5-8 the PT will come once per week and in the last 8 weeks once bi-weekly.

Official Title
-----------------
A Home Based Resistance Training Program for Obese Adults With Type 2 Diabetes

Conditions
-----------------
Diabetes

Intervention / Treatment
-----------------
* Behavioral: Resistance Training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Type 2 Diabetes Overweight and Obese (BMI>28) Living inside of City limits Exclusion Criteria: Ischemic heart disease Osteoporosis Musculoskeletal abnormalities Currently performing resistance training

Ages Eligible for Study
-----------------
Minimum Age: 25 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Resistance Training|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HbA1c |  |  | 
| Muscular strength |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fasting blood glucose, insulin, lipid concentrations, C-reactive protein, body composition (DEXA), exercise adherence, behaviour change, psychosocial predictors of resistance training, quality of life. |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Diabetes, Resistance Training
Changing Opioid Users' Negative Attitudes Toward Medication Assisted Treatment

Study Overview
=================
Brief Summary
-----------------
In this treatment development project, the investigators propose to develop and assess the feasibility and acceptability of a narrative-based video intervention and accompanying workbook (entitled MATTeRS: Medication Assisted Treatments: Telling Real Stories) designed to be used by people in inpatient opioid detoxification. Using the Health Belief Model as a framework, videos will provide information about the uses and outcomes of Medication Assisted Treatments (MATs) compared to other or no post-detoxification treatment through the use of narratives from real people's lives.

Official Title
-----------------
Changing Opioid Users' Negative Attitudes Toward Medication Assisted Treatment

Conditions
-----------------
Opioid Use Disorder

Intervention / Treatment
-----------------
* Behavioral: MATTeRS Video
* Behavioral: Didactic Video


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Currently undergoing inpatient opioid detoxification; Qualify for use of one or more MATs; Have health insurance; Able to read and speak English; Aged 18 or older; No suicide ideation or behavior requiring immediate attention; Live in the Rhode Island or Massachusetts area and have a working telephone; Able to provide two contact persons to verify location and in case we are unable to reach the participant during the study; Do not have probation/parole requirements that might interfere with protocol participation.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: MATTeRS Video<br> | Behavioral: MATTeRS Video<br>* Narrative-based video intervention and accompanying workbook<br>|
| Active Comparator: Didactic Video<br> | Behavioral: Didactic Video<br>* Education only video<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Initiation of Medication Assisted Treatment | Whether or not patients started medication-assisted treatment during the assessment period. | 1 Month Post-Discharge |
Study Evaluating Venlafaxine ER in Recurrent Depression

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to review the long-term comparative efficacy of venlafaxine ER in achieving and sustaining remission (wellness) in patients with recurrent major depression

Official Title
-----------------
An Acute and Continuation Phase Study of the Comparative Efficacy Study of Venlafaxine ER (Effexor® XR) and Fluoxetine (Prozac®) in Achieving and Sustaining Remission (Wellness) in Patients With Recurrent Unipolar Major Depression; Followed by a Long Term Randomized, Placebo-Controlled Maintenance Treatment Study in Patients Treated Initially With Venlafaxine ER

Conditions
-----------------
Depressive Disorder, Major, Recurrence

Intervention / Treatment
-----------------
* Drug: Venlafaxine ER


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria Clinical diagnosis for recurrent major depression Exclusion Criteria The patient has failed on an adequate trial of fluoxetine, venlafaxine or venlafaxine ER during the current episode of major depression or the patient is treatment-resistant Known hypersensitivity to venlafaxine or fluoxetine History or presence of clinically significant hepatic, cardiovascular or renal disease, or other serious medical disease, including history of seizure disorder

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Venlafaxine ER|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Depression
Remote Monitoring of Home Exercise in Peripheral Arterial Disease

Study Overview
=================
Brief Summary
-----------------
Many patients with blockages in the arteries in their legs (peripheral arterial disease, PAD) suffer from pain in their legs when walking. Exercise therapy is known to decrease pain levels as well as increase the distance that patients with PAD can walk. The purpose of this study is to understand whether home exercise using a digital exercise monitoring system (LIVMOR) with provider supervision/ feedback will improve walking distance compared to those undergoing home exercise using the same monitoring system but without provider supervision/ feedback.

Official Title
-----------------
Remote Monitoring of Home Exercise in Peripheral Arterial Disease

Conditions
-----------------
Peripheral Arterial Disease

Intervention / Treatment
-----------------
* Behavioral: Provider supervision/ feedback


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age >18 Diagnosis of PAD (based on ABI <0.9 in either leg or prior intervention) with mild/moderate claudication Exclusion Criteria: Prior above ankle amputation Wheelchair bound Inability to walk >200m during 6 min walk test Use of walking aid other than cane Walking impairment for reason other than PAD Critical limb ischemia Planned vascular surgery within next 3 months, recent surgery within past 3 months

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Provider Supervised<br>Digital monitoring system with provider supervision | Behavioral: Provider supervision/ feedback<br>* Provider supervision/ feedback provided before and after walking sessions<br>|
| No Intervention: Self Supervised<br>Digital monitoring system without provider supervision | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in 6 minute walk test distance between groups | Change in 6 minute walk test distance between groups | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Walking Impairment Questionnaire score | Change in Walking Impairment Questionnaire score between groups | 12 weeks | 
| Change in VascuQOL-6 (VQ6) quality of life survey | Change in VascuQOL-6 (VQ6) quality of life survey between groups | 12 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
PAD, Home walking, Remote monitoring, Claudication
Suspected Cases of Carbon Monoxide Poisoning in the ED

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to collect non-invasive observational data in suspected or known carbon monoxide poisoning.

Official Title
-----------------
ED Data Collection of Suspected Carbon Monoxide Poisoning

Conditions
-----------------
Carbon Monoxide Poisoning

Intervention / Treatment
-----------------
* Device: Observational data collection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Known or suspected carbon monoxide poisoning Exclusion Criteria: Less than 18 years of age

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Observational data collection|Observational data collection|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Values from the test device will be compared to the values from co-oximetry to determine the accuracy of the test device |  | Through study completion, an average of 2 years. |
Lung Ultrasonography After Laparoscopic Gynecologic Surgery

Study Overview
=================
Brief Summary
-----------------
This study evaluates the influence of surgical and anesthesia-related variable on atelectasis formation during laparoscopic gynecologic oncologic surgery by lung ultrasound.

Detailed Description
-----------------
Approximately 50% of patients undergoing general anesthesia are hypoxemic. Anaesthesia, paralysis, high concentrations of oxygen, inadequate level of PEEP, capnoperitoneum, Trendelenburg position all result in persistent atelectasis. Lung ultrasound is a safe and accurate bedside tool useful to study lung aeration. The aim of the investigator's study was to assess the impact of general anesthesia and laparoscopic gynecologic oncologic surgery on post-operative atelectasis and related oxygenation changes using lung ultrasound.

Official Title
-----------------
Lung Ultrasonography for the Assessment of Perioperative Atelectasis After Laparoscopic Gynecologic Oncologic Surgery

Conditions
-----------------
Pulmonary Atelectasis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients older than 18 yo undergoing laparoscopic surgery for gynecologic surgery who provide written informed consent. Exclusion Criteria: age < 18 yo; pregnancy; refused to partecipate; known pulmonary metastasis; preexisting pulmonary conditions (COPD, pleural effusion, pulmonary consolidations, lung edema, pulmonary embolism); anesthesia with mechanical ventilation in the 2 weeks.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assess if LUS score measured after surgery is higher that LUS score measured before induction of anesthesia | Each lung will be divided in 6 areas and a score from 0 to 3 will be assigned to each field depending on the loss of aereation detected by ultrasound. LUS score will range between 0 and 36. Lung ultrasound will be performed before induction of anesthesia and 10 minutes after extubation. | The outcome will be measured 10 minutes after extubation | 
| Correlation between the increase of LUS score after surgery and surgical or anesthesia-related variables. | Logistic regression will be applied to consider the correlation between Delta LUS and the following variables: lenght of surgery duration of pneumoperitoneum angle of Trendelenburg potision duration of mechanical ventilation intraoperative fluids duration of apnea from induction to intubation | The outcome will be measured 10 minutes after extubation | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pulmonary Atelectasis, Lung Ultrasound, Laparoscopic Surgery