Reward Processing in Mental Illness

Study Overview
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Brief Summary
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The purpose of this study is to examine the nature of reward processing dysfunctions in schizophrenia using neuroimaging techniques that capture in vivo brain functioning, such as EEG and fMRI.

Detailed Description
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This experiment takes place over the course of two or three days. On each visit day, the experiment will involve a brief interview session, electroencephalography (EEG) recording,and/or a magnetic resonance imaging (MRI). Screening tests or procedures include: If you are female of child bearing potential, you must complete a urine pregnancy test for the MRI procedure You will be asked a series of questions about your mental health and your background If the screening exam shows that you can be in the main part of the study and you choose to continue, these are the tests and procedures that you would complete on one or two test days: EEG recording: In this procedure, the researcher will assess your brain function while you perform simple computer-based tasks. The computer tasks involve presentation of pictures to which you respond by pressing a button. You will be given clear instructions and a chance to practice before each task. While you are performing these tasks, we will record the weak electrical signals produced by your brain, or brain waves, using a technique called electroencephalography (EEG). In order to record your EEG, sensors (small plastic discs) will be attached to specific locations on your scalp. Your scalp will be gently scrubbed before the sensors are attached. The sensors are held in place on your scalp using a nylon cap that fits snugly on your head. Sensors will also be attached above and below your eyes and will record your eye movements. It will take approximately one hour to attach the sensors. The entire EEG will take approximately 2 hours. Before you take part in the EEG session, please make sure to wash your hair and scalp. Do not use conditioner or a 2-in-1 shampoo/conditioner. Your hair should be dry before your arrival. We ask this in order to make the set-up process go more smoothly. MRI: In the fMRI procedure, we will use a magnet to measure blood flow to your brain while you do different cognitive tasks. You will be asked to lie down on a platform that can be slid into the middle of the magnet. A plastic MRI imaging coil will be placed around your head. You will not come into contact with the coil during the experiment. Foam pads will be placed around your head to limit head movement during the experiment. We will then slide you into the magnet. At different points during the experiment, you will be asked to do the same tasks you did in the training session prior to the scan. During the scan, you will be asked to either lie still and rest, or do some tasks similar to those you completed during your EEG. The entire MRI will take approximately two hours. If the researchers feel as though the quality of data collected by the scanner can be improved, you may be asked to return for an additional scan session. Brief interview session: There will be a series of questions about your education, smoking status, and economic background. You will also be given a list of words to read to the researcher. If you are a patient diagnosed with one of the above-mentioned psychiatric disorders, you will be asked to participate in an additional interview, lasting about one hour, focusing on how you have been feeling recently.

Official Title
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Multimodal Neural Investigation of Reward Processing in Mental Illness

Conditions
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Early-onset Schizophrenia

Intervention / Treatment
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* Diagnostic Test: Electroencephalography (EEG) and Magnetic Resonance Imaging (MRI)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The subject population will include 18 to 30 year old participants of any gender, race, and ethnicity. All subjects will be able to speak and understand English. Schizophrenia subjects: 1. Patients must be diagnosed with DSM-IV schizophrenia, schizophreniform, or schizoaffective disorder based on a SCID-P interview. Depression subjects: 1. Patients must be diagnosed with DSM-V Major Depressive Disorder based on a SCID-P interview. Post Traumatic Stress Disorder subjects: 1. Patients must be diagnosed with DSM-V Post Traumatic Stress Disorder based on a SCID-P interview. Gambling Disorder subjects: 1. Patients must be diagnosed with DSM-V Gambling Disorder based on a SCID-P interview. Comparison subjects: 1. Control participants must not have past or present Axis I diagnosis as determined by the SCID-NP. Exclusion Criteria: All subjects: A hearing deficit greater than 40dB in both ears detected during the hearing test Substance dependence, as per clinical judgment, in the past 1 year (except caffeine and nicotine) A history of significant medical/neurological disease such as cardiac, thyroid, renal, hepatic or neurological History of head injury with loss of consciousness greater than 15 minutes Any other condition or medication, which in the opinion of the investigator would preclude participation in the study. Non-English speaking. Comparison subjects: 1. Any first-degree relative with schizophrenia or bipolar disorder.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with Recent Onset Schizophrenia<br>Individuals who have been diagnosed with Schizophrenia, Schizoaffective Disorder, or Schizophreniform Disorder within the past five years and meet our research criteria for symptoms indicative of these diseases within the past five years. | Diagnostic Test: Electroencephalography (EEG) and Magnetic Resonance Imaging (MRI)<br>* We will use these techniques combined with tests of reward anticipation and clinical interviews to explore connections between these measures and activity in the brain in patients with a diagnosis of schizophrenia, major depressive disorder, gambling disorder, or post traumatic stress disorder and healthy controls.<br>|
| Patients with Major Depressive Disorder<br>Individuals who have been diagnosed with Major Depressive Disorder within the past five years and meet our research criteria for symptoms indicative of this disease within the past five years. | Diagnostic Test: Electroencephalography (EEG) and Magnetic Resonance Imaging (MRI)<br>* We will use these techniques combined with tests of reward anticipation and clinical interviews to explore connections between these measures and activity in the brain in patients with a diagnosis of schizophrenia, major depressive disorder, gambling disorder, or post traumatic stress disorder and healthy controls.<br>|
| Patients with Gambling Disorder<br>Individuals who have been diagnosed with Gambling Disorder within the past five years and meet our research criteria for symptoms indicative of this disease within the past five years. | Diagnostic Test: Electroencephalography (EEG) and Magnetic Resonance Imaging (MRI)<br>* We will use these techniques combined with tests of reward anticipation and clinical interviews to explore connections between these measures and activity in the brain in patients with a diagnosis of schizophrenia, major depressive disorder, gambling disorder, or post traumatic stress disorder and healthy controls.<br>|
| Patients with Post Traumatic Stress Disorder<br>Individuals who have been diagnosed with Post Traumatic Stress Disorder within the past five years and meet our research criteria for symptoms indicative of this disease within the past five years. | Diagnostic Test: Electroencephalography (EEG) and Magnetic Resonance Imaging (MRI)<br>* We will use these techniques combined with tests of reward anticipation and clinical interviews to explore connections between these measures and activity in the brain in patients with a diagnosis of schizophrenia, major depressive disorder, gambling disorder, or post traumatic stress disorder and healthy controls.<br>|
| Healthy Controls<br>Individuals who have not met criteria for a psychiatric, mood, or gambling disorder within their lifetime according to our research criteria for symptoms indicative of a psychiatric, mood, or gambling disorder. | Diagnostic Test: Electroencephalography (EEG) and Magnetic Resonance Imaging (MRI)<br>* We will use these techniques combined with tests of reward anticipation and clinical interviews to explore connections between these measures and activity in the brain in patients with a diagnosis of schizophrenia, major depressive disorder, gambling disorder, or post traumatic stress disorder and healthy controls.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| EEG | Electroencephalography, measures signals from the brain while participants conduct specific tasks that measure memory and attention. | At time of visit | 
| MRI | Magnetic Resonance Imaging, measures activity in, and takes detailed pictures of the brain while participants conduct specific tasks that measure memory and attention. | At time of visit | 
| Reward Processing Tasks | A slot machine task where participants can win real money while participating in an EEG and MRI | At time of visit |