Inflammatory Biomarkers for the Diagnosis of oPRES

Study Overview
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Brief Summary
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The purpose of this study is to explore the inflammatory biomarkers for the diagnosis of obstetric posterior reversible encephalopathy syndrome.

Detailed Description
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The investigators retrospectively collected data (General information, clinical data, biochemical indicators, imaging features, and pregnancy outcome) from pregnant woman diagnosed with PRES to explore the inflammatory biomarkers for the diagnosis of oPRES during 2012 to 2021.Then, the investigators grouped all the patients into PRES group (PE or E with PRES) and NOT-PRES group (PE or E without PRES) according to the diagnostic criteria of PRES. Then, the investigators analysed the inflammatory biomarkers, such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), and so on of two groups, and compared the difference of tow groups.

Official Title
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Inflammatory Biomarkers for the Diagnosis of Obstetric Posterior Reversible Encephalopathy Syndrome

Conditions
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Posterior Reversible Encephalopathy Syndrome, Inflammatory Biomarkers, Neutrophil-lymphocyte Ratio

Intervention / Treatment
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* Other: Whether the PE or E patient combined with PRES


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Pregnant women were diagnosed of PE or E. All patients were examined the cranial imaging (MRI or CT), and imaging findings meeting the diagnostic criteria of PRES or normal. all patients provided written informed consent. Exclusion Criteria: patients combined with other neurological disorders patients combined with mental illness

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| PRES group<br>patients in PE or E with PRES | Other: Whether the PE or E patient combined with PRES<br>* According to the Diagnostic criteria of PRES, all the patients grouped into two groups.<br>|
| NON-PRES group<br>patients in PE or E without PRES | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| inflammatory biomarkers | The values of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and monocyte-lymphocyte ratio will be measured. | Inflammatory biomarkers were collected within 1 day after the onset of symptoms. | 
| cranial Imaging | According to the cranial Imaging, PE or E patients were grouped into PRES group (typical features presence of vasogenic edema in the white matter of the portions of both cerebral hemispheres) and NOT-PRES group (imaging findings were normal). | Cranial Imaging was examined within 3 days after the onset of symptoms, such as s headaches, visual changes, seizures, consciousness impairment. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| other biochemical parameters | The levels of C-Reactive protein (CRP) will be measured,and CRP﹥8000μg/L means a worse outcome. | biochemical parameters were collected within 1 week of the hospital stay. | 
| Blood Pressure(BP) | blood pressure including systolic blood pressure (SBP), and diastolic blood pressure (DBP). | The BP of patients was obtained within 1hour after the onset of symptoms. | 
| pregnancy outcomes | The rates of stillbirth and premature birth (gestation less than 37 weeks) in PRES patients. | The pregnancy outcomes will record immediately when the patients deliver. |