Dose Finding Evaluation of Kudzu Root Extract in Women With Menopause Symptoms

Study Overview
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Brief Summary
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The aim of the study is to investigate effects of daily intake of Nordic Kudzu for 28 days in 5 groups of 10 menopausal women with symptoms. Groups:1) 3 capsules x3/day, 2) 3 capsules x2/day, 3) 2 capsules x3/day, 4) 2 capsules x2/day, 5) 3 capsules x1/day. Each capsule equal 1.26 g kudzu root extract. Outcome measures: Serum and urine levels of biochemical marker of bone-degradation, CTX-I, and symptoms of menopause using the Meopause Rating Scale (MRS).

Official Title
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An Open-label, Single-center, Randomized, Exploratory, Dose-finding Study to Evaluate Short Term Treatment With Different Doses of Oral Powdered Kudzu Root Extract in Women With at Least Mild Menopause Symptoms

Conditions
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Menopause

Intervention / Treatment
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* Dietary Supplement: 3 caps x3/day
* Dietary Supplement: 3 caps x2/day
* Dietary Supplement: 2 caps x3/day
* Dietary Supplement: 2 caps x2/day
* Dietary Supplement: 3 caps x1/day


Participation Criteria
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Eligibility Criteria
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Inclusion criteria: Signed and dated informed consent Women in the age between 45 and 60 years considered late peri- (defined as having had a menstrual period more than 3 months ago but less than 12 months ago) or postmenopausal (defined as at least 12 consecutive months without any menstrual flow) at the time of screening Menopause symptoms, defined as a score of at least 5 in the Menopausal Rating Scale (MRS) at screening Body Mass Index between 18 and 40 kg/m2 at the time of screening Exclusion criteria: Allergy/hypersensitivity/intolerance to any components in the Kudzu herbal extract powder capsules Past or present significant co-morbidity including, but not limited to: Uncontrolled, severe renal, hepatic, cardiovascular, hematologic, gastrointestinal, metabolic, endocrine, pulmonary, cardiac or neurologic disease History of breast cancer or other malignancy, except adequately treated basal cell or squamous cell carcinoma of the skin, or resected cervical atypia or carcinoma in situ Known history of clinically significant thromboembolism Current alcohol abuse Pregnancy, determined by positive serum human chorionic gonadotropin (hCG) test prior to randomization, except for women considered postmenopausal Breastfeeding women Participation in a study trial with any investigational new drug or food supplement within 3 months prior to the start of the study Clinically significant ECG abnormalities, as judged by the investigator Clinically significant biochemistry abnormalities including but not limited to ALT or AST >2.5 x ULN or other clinically significant liver function parameters, as judged by the investigator Investigator considering the subject inappropriate for inclusion in the study based on medical interview and/or physical examination Use of local or systemic conventional hormone therapy regardless of indication or alternative medication including dietary supplements for the treatment of menopausal symptoms within 28 days prior to randomization.

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Unblinded, single-center, randomized, exploratory, dose-finding study. 1:1:1:1:1 randomisation to 5 groups of different doses for 28 days.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group 1<br>10 subjects | Dietary Supplement: 3 caps x3/day<br>* 3 capsules 3 times daily for 28 days<br>|
| Active Comparator: Group 2<br>10 subjects | Dietary Supplement: 3 caps x2/day<br>* 3 capsules 2 times daily for 28 days<br>|
| Active Comparator: Group 3<br>10 subjects | Dietary Supplement: 2 caps x3/day<br>* 2 capsules 3 times daily for 28 days<br>|
| Active Comparator: Group 4<br>10 subjects | Dietary Supplement: 2 caps x2/day<br>* 2 capsules 2 times daily for 28 days<br>|
| Active Comparator: Group 5<br>10 subjects | Dietary Supplement: 3 caps x1/day<br>* 3 capsules 1 times daily for 28 days<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Menopause Rating Scale (MRS) | Questionaire. 11 likert scales 0-4. Total score ranges: 0-44 (0 indicating no symptoms, 44 indicating max symptoms. | 28 days | 
| Serum CTX-I | Blood based biomarker of bone resorption | 28 days | 
| Urine CTX-I | Urine based biomarker of bone resorption | 28 days |