NIV and CPAP Failure Predictors in COVID-19 Associated Respiratory Failure

Study Overview
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Brief Summary
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Evaluate HACOR socre utility and efficacy in predicting NIV and/or CPAP failure in patients with COVID-19 associated respiratory failure. Propose adaptations to HACOR score based on the state of art of COVID-19

Detailed Description
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Evaluate HACOR socre utility and efficacy in predicting NIV and/or CPAP failure in patients with COVID-19 associated respiratory failure. Propose adaptations to HACOR score based on the state of art of COVID-19 - this adaptations may include radiologic aggravation and monitoring of CRF, ferritin, LDH, d-dimers, NT-proBNP, troponin I, GOT, GPT, blood count

Official Title
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NIV and CPAP Failure Predictors in COVID-19 Associated Respiratory Failure

Conditions
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Covid-19, Respiratory Failure

Intervention / Treatment
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* Other: Monitoring for aggravation
* Other: Evaluate HACOR score effectivity in this patients


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with acute respiratory failure due to COVID-19 who have initiated NIV or CPAP based on assistant clinician decision Exclusion Criteria: Patients with imediate indication to invasive mechanical ventilation Patients with any formal contraindication to noninvasive respiratory support

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| NIV<br>Patients on Bilevel NIV | Other: Monitoring for aggravation<br>* Monitor patients on CPAP or NIV and analyzing possible variables that may predict failure, namely: lymphopenia thrombocytopenia CRP ferritin LDH troponin I NT-ProBNP Liver enzymes D-dimers radiologic aggravation  1 day and 1 week after starting NIV or CPAP<br>Other: Evaluate HACOR score effectivity in this patients<br>* Apply the HACOR score after starting NIV and CPAP and later verify if it was effective in predicting NIV/CPAP failure<br>|
| CPAP<br>Patients on CPAP | Other: Monitoring for aggravation<br>* Monitor patients on CPAP or NIV and analyzing possible variables that may predict failure, namely: lymphopenia thrombocytopenia CRP ferritin LDH troponin I NT-ProBNP Liver enzymes D-dimers radiologic aggravation  1 day and 1 week after starting NIV or CPAP<br>Other: Evaluate HACOR score effectivity in this patients<br>* Apply the HACOR score after starting NIV and CPAP and later verify if it was effective in predicting NIV/CPAP failure<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HACOR score efficacy | Analyze if HACOR score is effective in predicting nonivasive ventilation failure in COVID-19 associated respiratory failure | 1 hour after initation of CPAP or NIV | 
| HACOR score addaptation | Analyze the role of possible variables to be added to HACOR score in order to improve efficay in COVID-19 patients | 1 - 2 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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noninvasive ventilation, CPAP, Covid-19, Respiratory failure, HACOR score