Effectiveness of a Home-Based Cognitive Rehabilitation Program in Patients With MCI

Study Overview
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Brief Summary
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In this study, a more specific and systematic Home-Based Cognitive Rehabilitation Program Driven by a Tablet Application is developed and the purpose of the program is to check whether cognitive function is improved when the program is applied to patients with MCI.

Detailed Description
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The subjects of recruitment were the elderly with mild cognitive impairment living in the local community. Assessments were conducted 7 days before and after the intervention. Subjects received Korean-Montreal Cognitive Assessment(MoCA), semantic verbal emory test (SVLT), number memorization test; Digit Span Test (DST), category word fluency test (CWFT), phonemic word fluency test (PWFT), Korean-mini mental state test (K-MMSE), and geriatric depression scale (GDS) before and 8 weeks after the intervention.

Official Title
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Effectiveness of a Home-Based Cognitive Rehabilitation Program Driven by a Tablet Application in Patients With Mild Cognitive Impairment

Conditions
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Cognitive Impairment, Mild Cognitive Impairment

Intervention / Treatment
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* Other: Home based cognitive rehabilitation program


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men and women over the age of 55 Those who have visual and auditory abilities without difficulties in conducting this research Those with K-MMSE (Korean-Mini Mental State Examination) score of 24 or higher and 16≤K-MoCA score<23 In the case of patients taking dementia treatment, those who have the same treatment regimen and dose for 3 months or more from the screening date A person who can understand and respond to the questionnaire questions. A person who voluntarily decided to participate in this study and gave written consent to the informed consent form Exclusion Criteria: Those with a history of alcohol or drug abuse, Those with a past history of uniaxial psychiatric disorders, including intellectual disability, schizophrenia, alcoholism, and bipolar disorder A person who is unable to communicate Those who show all neurological symptoms that cause cognitive decline, such as Parkinson's disease, cerebral hemorrhage, brain tumor, and hydrocephalus Those with a record of being unconscious for more than 1 hour due to head trauma or mild repetitive head trauma Those with symptoms of depression that may affect cognitive function

Ages Eligible for Study
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Minimum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Home based cognitive rehabilitation program<br>The intervention was conducted for 30 minutes each time, 3 times a week for 8 weeks, a total of 24 times. | Other: Home based cognitive rehabilitation program<br>* The home based cognitive rehabilitation program intervention was conducted for 30 minutes each time, 3 times a week for 8 weeks, a total of 24 times.<br>|
| No Intervention: No intervention<br>In the control group, natural cognitive changes with the passage of time were observed. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of the Korean-Montreal cognitive assessment(MoCA) score | It is a tool to evaluate overall cognitive function. Possible scores range from 0(lowest cognitive function) to 30 (highest cognitive function). Change = Paired t-test with baseline score and week 8 score. | Baseline and Week 8 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of the semantic verbal emory test (SVLT) score | It is a tool to evaluate language memory function. Possible scores range from 0(lowest) to 36 (highest). Change = Paired t-test with baseline score and week 8 score. | Baseline and Week 8 | 
| Change of the Digit Span Test (DST) score | It is a tool to evaluate number memorization and attention. Possible scores range from 0(lowest) to 9 (highest). Change = Paired t-test with baseline score and week 8 score. | Baseline and Week 8 | 
| Change of the category word fluency test (CWFT) score | It is a tool to evaluate executive function. In one minute, the speak words of the given category is performed, and the number of words spoken within the time is evaluated as a score. Change = Paired t-test with baseline score and week 8 score. | Baseline and Week 8 | 
| Change of the phonemic word fluency test (PWFT) score | It is a tool to evaluate executive function. In one minute, the speak words that start with a given phoneme is performed, and the number of words spoken within the time is evaluated as a score. Change = Paired t-test with baseline score and week 8 score. | Baseline and Week 8 | 
| Change of the geriatric depression scale (GDS) score | It is a tool to evaluate degree of depression. Possible scores range from 0(lowest depression) to 21 (highest depression). Change = Paired t-test with baseline score and week 8 score. | Baseline and Week 8 |