Heart Rate Variability and Postoperative Nausea Vomiting

Study Overview
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Brief Summary
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Propofol and sevoflurane have different effects on heart rate variability. It has not yet been reported whether this difference in effect remains at recovery time after anesthesia and the difference is related to postoperative nausea and vomiting has not been studied. The aim of this study is observe whether propofol and sevoflurane have different effects on heart rate variability during recovery and the differences can predict the occurrence of postoperative nausea and vomiting.

Detailed Description
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Different types of anesthetics have different effects on heart rate variability. However It has not yet been reported whether this difference in effect remains at recovery time after anesthesia. Several studies have been reported that preoperative heart rate variability predicted the occurence of postoperative nausea and vomiting. However, whether the difference in heart rate variability after anesthesia is related to the difference in postoperative nausea and vomiting has not been studied. Therefore, this study aims to observe whether propofol and sevoflurane have differences during recovery period after anesthesia in heart rate variabiliy. In addition, we want to examine that these differences during recovery period in heart rate variability can predict the occurrence of nausea and vomiting within 24 hours after surgery.

Official Title
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The Effects of Propofol and Sevoflurane on Postoperative Heart Rate Variability and Postoperative Nausea Vomiting

Conditions
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Postoperative Nausea and Vomiting

Intervention / Treatment
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* Drug: Propofol
* Drug: Sevoflurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Scheduled breast surgery under general anesthesia Exclusion Criteria: Arrhythmia Uncooperative with the measuring heart rate variability Diabetes Hypertension on medication Patients taking psychiatric drugs Thyroid disease

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Propofol<br>General anesthesia using propofol infusion | Drug: Propofol<br>* General anesthesia using propofol infusion<br>* Other names: Propofol infusion;|
| Sevoflurane<br>General anesthesia using sevoflurane | Drug: Sevoflurane<br>* General anesthesia using sevoflurane<br>* Other names: Sevoflurane inhalation;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| heart rate variability in recovery room | Postoperative heart rate variability measuring at recovery room Frequency domain result: total power, low frequency power, high frequency power, Low frequency/high frequency power ratio | within 1 hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative nausea vomiting impact scale | Q1. Have you vomited or had dry-retching? 0. No Once twice 3 or more times Q2. Have you experienced a feeling of nausea? If yes, has your feeling of nausea interfered with activities of daily living? 0. not at all Sometimes often or most of the time All of the time Add the numerical responses to questions 1 and 2. (total score 0 6) | 48 hours after anesthesia | 
| The incidence of postoperative nausea and vomiting | the time of occurence | 48 hours after anesthesia | 
| Patient's satisfaction about postoperative nausea and vomiting | verbal rating scale (0 10), 0=very unsatisfied, 10=very satisfied | 48 hours after anesthesia | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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postoperative nausea and vomiting, heart rate variability, propofol, sevoflurane