Exploratory Investigation of Advanced PET/MRI Metrics for Bladder Cancer Characterization

Study Overview
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Brief Summary
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The overarching goal of this project is to explore whether associations exist between metrics obtained from PET/MRI incorporating advanced MRI sequences and features of bladder cancer, including grade, stage, and treatment response.

Detailed Description
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The investigators will assess an advanced non-Gaussian diffusion-weighted imaging (DWI) model termed diffusion kurtosis imaging, multi-echo T2 mapping, dynamic contrast-enhanced (DCE) MRI using a motion-robust high-temporal and high-resolution radial acquisition scheme employing compressed sensing, and simultaneously acquired 18-fluoro (18F)- fluorodeoxygluclose (FDG) data. Preliminary data demonstrates the investigators ability to execute and evaluate all of these techniques at the investigators center. The investigators hypothesize that these techniques will be sensitive to functional and metabolic differences between subsets of bladder cancer cases and will improve upon the performance of current imaging protocols in bladder cancer characterization. Moreover, the investigators believe that these techniques will provide complementary information, such that they may be combined in a synergistic fashion for bladder cancer evaluation.

Official Title
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Exploratory Investigation of Advanced PET/MRI Metrics for Bladder Cancer Characterization

Conditions
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Bladder Cancer

Intervention / Treatment
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* Procedure: PET/MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Histologic or imaging evidence of urothelial carcinoma of the bladder Age ≥ 18 years of age If female of childbearing potential, pregnancy test is negative. (In these instances, the patient will need to provide documentation of negative pregnancy test results.) Exclusion Criteria: Inability to tolerate MRI including conditions such as claustrophobia or inability to lay flat for > 45 minutes. Presence of pacemaker/implantable cardiac device (ICD) or perfusion pumps Ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial heart, valves with steel parts, metal fragments, shrapnel, bullets, tattoos near the eye, or steel implants. Substance abuse, medical, psychological, or social conditions that may interfere with the patient's participation in the study

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: PET/MRI<br>Patient receives MRI | Procedure: PET/MRI<br>* Simultaneous PET/MRI (3T system)<br>* Other names: Siemens Biograph mMR;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tumor standardized uptake value (SUV) from 18-fluorodeoxyglucose PET/MRI scan | The tumor SUV value obtained approximately one hour following 18-fluorodeoxyglucose administration will be measured. | within one week of study completion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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bladder cancer, MRI, PET