Chongqing Intracerebral Hemorrhage Study

Study Overview
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Brief Summary
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The Chongqing intracerebral hemorrhage study is a multi-center, prospective, observational study led by professor Qi Li from Chongqing Medical University. Professor Peng Xie will be the senior consultant for the study. The Chongqing intracerebral hemorrhage study will focus on the epidemiology, natural history, pathogenesis, laboratory, radiological aspects, clinical outcomes and the effects of treatment in patients with intracerebral hemorrhage. The clinical, laboratory, imaging, genetic and outcome data of patients diagnosed with acute intracerebral hemorrhage will be prospectively collected. The prognosis of patients with intracerebral hemorrhage will be assessed by using several outcome measure scales at different time points.

Detailed Description
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The Chongqing intracerebral hemorrhage study will try to address several key issues in ICH. The baseline clinical data including demographic, disease severity scores, prior drug history and relevant medical history, premorbid mRS scores will be prospectively recorded. The admission and follow-up imaging data of all registered patients will be saved as Dicom format for future use and review. The functional outcomes will be assessed and recorded by experienced neurologists.

Official Title
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Chongqing Intracerebral Hemorrhage Study

Conditions
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Intracerebral Hemorrhage, Stroke, Hematoma

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age >= 18 years Informed consent to participate in the study Patients diagnosed with CT-confirmed spontaneous Intracerebral Hemorrhage (ICH) Patients are willing to participate in the follow up assessment Exclusion Criteria: Did not agree to participate in the study Secondary ICH to hemorrhagic infarction or tumor bleeding etc. Traumatic ICH

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| benigh hematoma<br>Patients with novel imaging markers or clinical features suggestive of a relatively benigh hematoma (less likely to expand and have a relatively good outcome). | |
| malignant hematoma<br>Patients with novel imaging markers or clinical features suggestive of a relatively bad hematoma (more likely to expand and have a relatively poor outcome). | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hematoma volume growth at 24 hours | To assess early hematoma volume growth at 24 hours | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| functional outcome at 3 months assessed by modified Ranking Scale | assess functional outcome at 3months using mRS | 3 months | 
| early neurological deterioration assessed by NIHSS score at 24 hours | To assess early neurological deterioration using NIHSS score at 24 hours | 24 hours | 
| early neurological deterioration assessed by NIHSS at 48 hours | To assess early neurological deterioration using NIHSS score at 48 hours | 48 hours | 
| early neurological deterioration assessed by NIHSS score | To assess early neurological deterioration using NIHSS score at 72 hours | 72hours | 
| perihematoma edema volume measurement at 24 hours | to measure the perihematoma edema volume at 24 hours | 24 hours | 
| perihematoma edema volume measurement at 72 hours | to measure the perihematoma edema volume at 72 hours | 72 hours | 
| intraventricular hemorrhage growth | to assess the presence of IVH at 24 hours | 24 hours | 
| major thromboembolic events | to assess the thromboembolic events 2 weeks after admission | 2 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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intracerebral hemrrohage, stroke, China, hematoma, CT, predictor, prognosis, outcome