The Establishment of China Bronchiectasis Registry and Research Collaboration

Study Overview
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Brief Summary
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The investigators meant to establish a multi-centered bronchiectasis patient registry for Chinese bronchiectasis patients. This would be the first bronchiectasis registry in China. Patients with all kinds of bronchiectasis would be enrolled.

Detailed Description
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A multi-centered bronchiectasis patient registry would be founded, which will include patients from three teaching hospital (Ruijin Hospital, Zhongshan Hospital and Shanghai Pulmonary Hospital) in Shanghai at the beginning. The network will be promoted to other cities and different places in China. Patients with bronchiectasis would be enrolled and detailed information would be recorded. Follow-up of patients would provide more information on the prognosis of disease. Optimal treatment studies for the patients will be initiated one by one based on the network. The investigators are committed to promoting clinical research and education in bronchiectasis, through sharing of protocols, research idea and expertise.

Official Title
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The Establishment of China Bronchiectasis Registry and the Optimal Treatment Research Collaboration for Bronchiectasis (BEChina)

Conditions
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Bronchiectasis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients diagnosed with bronchiectasis according to 'non-cystic fibrosis bronchiectasis guideline' published by British Thoracic Society in 2010. Patients who are willing to sign the consent form and participate in the study. Exclusion Criteria: Patients with incomplete essential information, which is needed for the integrity of data analysis. Essential information include CT images, respiratory sample cultures, spirometry and exacerbation history for at least one year. Patients under 18 years old.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients enrolled in the registry | To establish a multi-centered bronchiectasis registry in Shanghai | 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lung Function (FEV1, FVC, FEV1% pred, FVC% pred etc.) | Lung function would be tested by spirometry when patients visit the clinic. | recorded at baseline and re-tested every year, up to 3 years. | 
| Exacerbation | Exacerbation was defined as the use of antibiotics or even hospitalization due to the worsening of symptoms or emergence of new symptoms. | up to 3 years | 
| Aetiology | To analysis the possible cause of bronchiectasis in Shanghai, China. | at baseline | 
| Microbiology | Sputum or bronchoalveolar lavage fluid culture | At least 1 year before enrollment and 3 years during the follow-up | 
| Comorbidity | Comorbidity would be recorded. | At baseline and updated every year for up to 3 years | 
| Quality of Life Questionnaire-Bronchiectasis | The questionnaire asks patients questions about their current state of health. It could be downloaded from the website online. | At baseline and updated once a year for 3 years | 
| Bronchiectasis severity Score (BSI) | The scale is presented online. It consists of 9 items including Age, BMI(Body Mass Index), % FEV1 Predicted, Previous Hospital Admission in the past 2 years, number of exacerbations in previous year, MRC Breathlessness Score, Pseudomonas Colonisation, Colonisation with other organisms,affected lobes. 0-4 Mild Bronchiectasis. 5 - 8 Moderate Bronchiectasis. 9 + Severe Bronchiectasis. | At baseline and updated once a year for 3 years | 
| E-FACED score | It consists of 6 items including exacerbation history in the past year, % FEV1 predicted, Age, Chronic colonization by Pseudomonas aeruginosa, n° of pulmonary lobes affected,and Dyspnea (measured by mMRC score) mild: 0-3 points, moderate: 4-6 points; and severe: 7-9 points | At baseline and updated once a year for 3 years | 
| Mortality |  | 3 years | 
| modified Medical Research Council (mMRC) dyspnea score | - Not troubled by breathlessness except on strenuous exercise - Short of breath when hurrying or walking up a slight hill - Walks slower than contemporaries on level ground because of breathlessness, or has to stop for breath when walking at own pace - Stops due to breathlessness after walking 100m - House bound due to breathlessness, or breathless on dressing or undressing. | At baseline and updated once a year for 3 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Bronchiectasis, multi-centered registry