N2000-01: Double Infusion of Iodine I 131 Metaiodobenzylguanidine Followed by Autologous Stem Cell Transplantation

Study Overview
=================
Brief Summary
-----------------
RATIONALE: Giving iodine I 131 metaiodobenzylguanidine (^131I-MIBG) may kill neuroblastoma cells by delivering radiation directly to the tumor. A stem cell transplant using the patient's stem cells may be able to replace blood-forming cells destroyed by radiation therapy. PURPOSE: This phase I trial is studying the side effects and best dose of a double infusion of ^131I-MIBG followed by autologous stem cell transplantation in treating patients with refractory neuroblastoma.

Detailed Description
-----------------
OBJECTIVES: Primary Determine the maximum tolerated red marrow radiation dose delivered and associated toxic effects of escalating activity of iodine I 131 metaiodobenzylguanidine (^131I-MIBG) followed by autologous hematopoietic stem cell transplantation in patients with refractory neuroblastoma. Determine the number of days after stem cell transplantation to achieve absolute neutrophil count ≥ 500/mm^3 for 3 days and platelet count ≥ 20,000/mm^3 for 3 days (without transfusions) in patients treated with this regimen. Secondary Determine the response rate in patients treated with this regimen, based on lesions measurable by CT or MRI at study entry, patients with ^131I-MIBG scan-positive lesions only, and patients with minimal residual tumor in bone marrow who have complete response by immunocytology and morphology. Determine the tumor absorbed radiation dose in patients with measurable soft tissue lesions treated with this regimen. Correlate, if possible, TP53 mutations with response in patients with accessible bone marrow tumor treated with ^131I-MIBG. OUTLINE: This is a dose-escalation, multicenter study. Iodine I 131 metaiodobenzylguanidine (131I-MIBG) therapy: Patients receive^131I-MIBG IV over 2 hours on days 0 and 14. Cohorts of 3-6 patients receive escalating doses of ^131I-MIBG until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. Stem cell transplantation therapy: Patients undergo autologous peripheral blood stem cell transplantation on day 28. Patients receive filgrastim (G-CSF) IV over 1 hour OR subcutaneously daily beginning on day 28 and continuing until blood counts recover. Patients are followed every 3 months for 1 year and then annually thereafter. PROJECTED ACCRUAL: A total of 9-18 patients will be accrued for this study within 2 years.

Official Title
-----------------
I-MIBG Escalating Dose Rapid Sequence Double Infusion Followed By Autologous Stem Cell Infusion For Refractory Neuroblastoma

Conditions
-----------------
Neuroblastoma

Intervention / Treatment
-----------------
* Biological: filgrastim
* Procedure: autologous bone marrow transplantation
* Procedure: peripheral blood stem cell transplantation
* Radiation: iobenguane I 131


Participation Criteria
=================
Eligibility Criteria
-----------------
DISEASE CHARACTERISTICS: Diagnosis of neuroblastoma Confirmed by at least 1 of the following methods: Histology Clumps of tumor cells in bone marrow with elevated urinary catecholamine metabolites High-risk disease Poor response to induction therapy OR relapse defined by any of the following: No response, stable disease, or mixed response after a minimum of 3 prior courses of chemotherapy More than 100 tumor cells per 10^5 nucleated cells on bone marrow immunocytology after at least 3 prior courses of chemotherapy Progressive disease at any time during or after therapy Patients with massive bone marrow invasion (more than 50% replacement of bone marrow by tumor cells) are allowed Must have positive iodine I 131 metaiodobenzylguanidine (^131I-MIBG) within the past 6 weeks or subsequent to any other prior antitumor therapy delivered within the past 6 weeks Must meet the following criteria for minimum number of autologous stem cells: Unpurged peripheral blood stem cells (PBSC) Minimum of 1,500,000/mm^3 CD34-positive cells/kg Collected products must have < 1 tumor cell/100,000 normal cells by immunocytology PBSC purged with immunomagnetic beads Minimum of 1,000,000/mm^3 viable CD34-positive cells/kg Collected products must have < 1 tumor cell/100,000 normal cells by immunocytology CD34-positive selected PBSC products are not allowed Patients who had PBSC collected previously with no immunocytological testing available may use those products provided bone marrow is tumor free by bilateral bone marrow aspirate AND biopsy for morphology is performed within 4 weeks before PBSC collection Patients with no tumor involvement in bone marrow at diagnosis and PBSC collection before any disease progression do not require documentation of negative bone marrow morphology PATIENT CHARACTERISTICS: Age 1 to 30 Performance status ECOG 0-2 Life expectancy Less than 1 year Hematopoietic Absolute neutrophil count ≥ 500/mm^3 Platelet count ≥ 50,000/mm^3 (without transfusion) Hemoglobin ≥ 8 g/dL (transfusion allowed) Hepatic AST and ALT ≤ 5 times normal Bilirubin < 2 times normal Renal Creatinine ≤ 1.5 mg/dL Glomerular filtration rate OR 12-hour creatinine clearance ≥ 60 mL/min/1.73m^2 Cardiovascular Ejection fraction ≥ 55% by echocardiogram or MUGA OR Fractional shortening ≥ 30% OR above lower limit of normal by echocardiogram Pulmonary Normal lung function No dyspnea at rest No exercise intolerance No oxygen requirement Other Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception Able to cooperate physically and psychologically with radiation isolation No disease of any major organ system that would preclude study participation No active infection requiring antivirals, antibiotics, or antifungals No weight that would require exceeding a maximum total allowable dose of ^131I-MIBG PRIOR CONCURRENT THERAPY: Biologic therapy At least 2 weeks since prior biologic or other non-myelosuppressive therapy Chemotherapy See Disease Characteristics At least 2 weeks since prior chemotherapy More than 3 months since prior myeloablative therapy Endocrine therapy Not specified Radiotherapy See Disease Characteristics At least 6 months since prior craniospinal, total abdominal, or whole lung radiotherapy At least 2 weeks since prior radiotherapy to any site No prior total body irradiation No prior radiotherapy to > 25% of bone marrow No prior ^131I-MIBG Surgery Not specified Other Recovered from all prior therapy Concurrent antifungal therapy allowed provided culture and biopsy are negative in suspected radiographic lesions Prior re-induction therapy for recurrent tumor allowed No concurrent antiretroviral therapy for HIV-positive patients No concurrent hemodialysis

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 30 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: filgrastim|nan|
|Procedure: autologous bone marrow transplantation|nan|
|Procedure: peripheral blood stem cell transplantation|nan|
|Radiation: iobenguane I 131|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
recurrent neuroblastoma