Running Effect on Cardiovascular and Muscular Parameters

Study Overview
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Brief Summary
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The purpose of the study is to determine the effect of 16 weeks of running exercise on various parameters related to heart, vascular systems, blood, and muscle in untrained males 30-50 years old. Further, the investigators assess which of the above mentioned parameters may explain the increase of running performance most accurate.

Official Title
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Effect of 16 Weeks of Running Exercise on Parameters Related to the Cardiovascular System, Blood and Muscle in Untrained Males 30-50 Years Old. A Randomized Controlled Study

Conditions
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Untrained, Males, 30-50 Years Old, Healthy

Intervention / Treatment
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* Other: exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: males untrained (< 2 endurance exercise sessions/week) 30-50 years old Exclusion Criteria: pathological changes of the heart inflammable diseases medication/diseases affecting cardiovascular system and muscle very low physical capacity (< 100 Watt at ergometry) obesity (BMI > 30 kg/m2) more than 2 weeks of absence during the interventional period more than 2 exercise session beside the intervention contraindication related to MRI-assessment (i.e. claustrophobia, magnetizable intracorporal artefacts)

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: exercise<br>16 weeks of running exercise | Other: exercise<br>* 16 week of periodized progressive running exercise 2-4 times/week<br>|
| No Intervention: control<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| myocardial mass/stroke volume | Atrial and ventricular volume and mass indexes were assessed by magnetic resonance imaging (MRI) | 4 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| maximal oxygen uptake | maximal oxygen uptake during running | 4 month | 
| Resting metabolic rate | Adaptation of resting metabolic rate to running exercise | 4 month | 
| muscle strength/power | Isometric muscle strength of the leg extensors Leg power as assessed by counter movement jump | 4 month | 
| myocardial volume | Functional and morphologic parameters of the heart as assessed by echocardiography | 4 month | 
| Intima media thickness | Carotid intima media thickness by high-resolution ultrasound | 4 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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running exercise, cardiac hypertrophy, blood, maximum oxygen uptake, intervention, untrained, males