Influence of Specific Collagen Peptides on Recovery After Exercise Induced Muscle Damage

Study Overview
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Brief Summary
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The present study aims at investigating the potential influence of specific collagen peptides on recovery after exercise induced muscle damage with focus on long-term effects.

Official Title
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Influence of Specific Collagen Peptides on Parameters of Biomechanical and Systemic Recovery After Exercise-induced Muscle Damage

Conditions
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Recovery

Intervention / Treatment
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* Dietary Supplement: Collagen
* Other: Concurrent training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: No subjective symptoms during physical exertion Stable weight and dietary behaviour Body Mass Index (BMI) between 18.5 and 24.9 No extensive strength/endurance sports so far (less than 3 h/week) No complaints during strenuous physical activity Exclusion Criteria: Circumstances that impair/prevent sporting activity (e.g. chronic heart disease, arrhythmia, heart valve disease, arthritis etc.) Intolerance/aversion to animal protein Arterial hypertension (high blood pressure) (syst > 200 mmHg and/or diast > 105 mmHg) at rest Presence of insulin-dependent diabetes mellitus Liver and/or kidney disease that precludes a high protein load Collagen supplementation or regular intake of other dietary supplements in the last 6 months.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Collagen<br>15g of collagen peptides ingested daily | Dietary Supplement: Collagen<br>* Participants ingest 15 grams of either specific collagen peptides or Placebo daily<br>Other: Concurrent training<br>* Both arms undergo a 12-week trainingintervention 3x/week<br>|
| Placebo Comparator: Placebo<br>15g of Placebo ingested daily | Other: Concurrent training<br>* Both arms undergo a 12-week trainingintervention 3x/week<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in maximal voluntary contraction (MVC) | Measured by isokinetic dynamometer | Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours) | 
| Change in rate of force development (RFD) | Measured by isokinetic dynamometer | Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours) | 
| Change in countermovement jump height (CMJ) | Measured by force plate | Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours) | 
| Change in subjective pain score | Measured by visual analogue scale | Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours) | 
| Change in Achilles tendon cross-sectional area | Measured by ultrasound | Baseline and after 12 weeks | 
| Change in Vastus Lateralis fibre length | Measured by ultrasound | Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours) | 
| Change in collagen related blood markers | Measured by blood analysis | Baseline (pre, post, 2 hours, 24 hours, 48 hours) and after 12 weeks (pre, post, 2 hours, 24 hours, 48 hours) | 
| Change in Achilles tendon echo intensity | Measured by ultrasound | Baseline and after 12 weeks | 
| Change in Vastus Lateralis echo intensity | Measured by ultrasound | Baseline and after 12 weeks | 
| Change in body composition parameters (fat mass, fat-free mass, extracellular mass, body cell mass) | Measured by bioelectrical impedance analysis | Baseline and after 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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MVC, Collagen peptides, Concurrent training, Ultrasound, RFD