Cerebral Blood Flow Effects of Resveratrol and Piperine in Humans

Study Overview
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Brief Summary
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Resveratrol is associated with a plethora of physiological effects in humans, including modulation of cerebral blood flow, despite apparently poor bioavailability. This study investigated whether the physiological effects of resveratrol could be affected when co-supplemented with piperine, an alkaloid which may be able to enhance the bioavailability of resveratrol.

Official Title
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Effects of Resveratrol Alone or in Combination With Piperine on Cerebral Blood Flow Parameters and Cognitive Performance in Humans

Conditions
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Healthy

Intervention / Treatment
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* Dietary Supplement: Trans- resveratrol
* Other: Placebo (silica)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Between the ages of 18-35 years old Healthy Non-smoker Exclusion Criteria: Not proficient in English Taking medication or herbal supplements Pregnant or breast feeding Heavy caffeine consumer History of head trauma, migraines, learning difficulties, ADHD, gastrointestinal problems. Food allergies of intolerances

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 250mg trans- resveratrol<br> | Dietary Supplement: Trans- resveratrol<br>* All 23 participants who completed the study took part in 3 conditions; receiving either 250mg resveratrol, 250mg resveratrol with 20mg piperine or placebo on separate days (with a 48hr-14 day wash-out period between each treatment) with the order dictated by Latin square. Treatment was in the form of powder and administered in capsule form, in a double blind manner.<br>Other: Placebo (silica)<br>* All 23 participants who completed the study took part in 3 conditions; receiving either 250mg resveratrol, 250mg resveratrol with 20mg piperine or placebo on separate days (with a 48hr-14 day wash-out period between each treatment) with the order dictated by Latin square. Treatment was in the form of powder and administered in capsule form, in a double blind manner.<br>|
| Experimental: 250mg trans-resveratrol with 20mg piperine<br> | Dietary Supplement: Trans- resveratrol<br>* All 23 participants who completed the study took part in 3 conditions; receiving either 250mg resveratrol, 250mg resveratrol with 20mg piperine or placebo on separate days (with a 48hr-14 day wash-out period between each treatment) with the order dictated by Latin square. Treatment was in the form of powder and administered in capsule form, in a double blind manner.<br>Other: Placebo (silica)<br>* All 23 participants who completed the study took part in 3 conditions; receiving either 250mg resveratrol, 250mg resveratrol with 20mg piperine or placebo on separate days (with a 48hr-14 day wash-out period between each treatment) with the order dictated by Latin square. Treatment was in the form of powder and administered in capsule form, in a double blind manner.<br>|
| Placebo Comparator: Placebo<br> | Dietary Supplement: Trans- resveratrol<br>* All 23 participants who completed the study took part in 3 conditions; receiving either 250mg resveratrol, 250mg resveratrol with 20mg piperine or placebo on separate days (with a 48hr-14 day wash-out period between each treatment) with the order dictated by Latin square. Treatment was in the form of powder and administered in capsule form, in a double blind manner.<br>Other: Placebo (silica)<br>* All 23 participants who completed the study took part in 3 conditions; receiving either 250mg resveratrol, 250mg resveratrol with 20mg piperine or placebo on separate days (with a 48hr-14 day wash-out period between each treatment) with the order dictated by Latin square. Treatment was in the form of powder and administered in capsule form, in a double blind manner.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Modulation of levels of total haemoglobin |  | 80 minutes following treatment administration | 
| Modulation of levels of deoxygenated haemoglobin |  | 80 minutes following treatment administration | 
| Modulation of levels of oxygenated haemoglobin |  | 80 minutes following treatment administration | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of participants displaying significant modulation of cognitive performance | Cognitive performance was assessed at baseline and then again 40 minutes post-treatment to assess if any changes had taken place. | 40-80 minutes post dose | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Resveratrol, Piperine, Cerebral blood flow, Near- infrared spectroscopy, Bioavailability