Comparison of Hyaluronidase and Dexametasone in Reduction of Postoperative Edema

Study Overview
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Brief Summary
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The present study is designed to reveal effectiveness of hyaluronidase and dexamethasone on reduction of postoperative edema, pain, trismus, and infection. For this purpose, 60 participants with symmetrical mandibular wisdom teeth enrolled the present study. All measurements and evaluations were performed before and 1, 2, 3, and 7 days later the operation.

Official Title
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Comparison of the Effects of Hyaluronidase and Dexamethasone on Reduction of Postoperative Edema in Impacted Wisdom Teeth Surgery

Conditions
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Edema, Pain, Trismus, Infection, Surgical Site

Intervention / Treatment
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* Drug: Hyaluronidase Injection mesomedica
* Drug: Dexamethasone dekort


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: symmetrical mandibular wisdom teeth with bone retention patients who are signed informed consent and acceptance of study involvement forms Exclusion Criteria: existence of any systemic disease existence of any periodical drug intake existence of difference in operation times of right and left impacted wisdom teeth extractions more than 5 minutes existence of pregnancy existence of breastfeeding
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: hyaluronidase<br> | Drug: Hyaluronidase Injection mesomedica<br>* injection of 150 IU hyaluronidase to perioperative region, submucosally.<br>|
| No Intervention: hyaluronidase control<br> | |
| Experimental: dexamethasone<br> | Drug: Dexamethasone dekort<br>* injection of 8 mg dexamethasone to perioperative region, submucosally.<br>|
| No Intervention: dexamethasone control<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| evaluation of the increase of edema in postoperative 1. day using a measuring tape in hyaluronidase experimental group | preoperative edema amount was subtracted from edema amount in 1. day in hyaluronidase experimental group | postoperative 1. day | 
| evaluation of the increase of edema in postoperative 2. day using a measuring tape in hyaluronidase experimental group | preoperative edema amount was subtracted from edema amount in 2. day in hyaluronidase experimental group | postoperative 2. day | 
| evaluation of the increase of edema in postoperative 3. day using a measuring tape in hyaluronidase experimental group | preoperative edema amount was subtracted from edema amount in 3. day in hyaluronidase experimental group | postoperative 3. day | 
| evaluation of the increase of edema in postoperative 7. day using a measuring tape in hyaluronidase experimental group | preoperative edema amount was subtracted from edema amount in 7. day in hyaluronidase experimental group | postoperative 7. day | 
| evaluation of the increase of edema in postoperative 1. day using a measuring tape in hyaluronidase control group | preoperative edema amount was subtracted from edema amount in 1. day in hyaluronidase control group | postoperative 1. day | 
| evaluation of the increase of edema in postoperative 2. day using a measuring tape in hyaluronidase control group | preoperative edema amount was subtracted from edema amount in 2. day in hyaluronidase control group | postoperative 2. day | 
| evaluation of the increase of edema in postoperative 3. day using a measuring tape in hyaluronidase control group | preoperative edema amount was subtracted from edema amount in 3. day in hyaluronidase control group | postoperative 3. day | 
| evaluation of the increase of edema in postoperative 7. day using a measuring tape in hyaluronidase control group | preoperative edema amount was subtracted from edema amount in 7. day in hyaluronidase control group | postoperative 7. day | 
| evaluation of the increase of edema in postoperative 1. day using a measuring tape in dexamethasone experimental group | preoperative edema amount was subtracted from edema amount in 1. day in dexamethasone experimental group | postoperative 1. day | 
| evaluation of the increase of edema in postoperative 2. day using a measuring tape in dexamethasone experimental group | preoperative edema amount was subtracted from edema amount in 2. day in dexamethasone experimental group | postoperative 2. day | 
| evaluation of the increase of edema in postoperative 3. day using a measuring tape in dexamethasone experimental group | preoperative edema amount was subtracted from edema amount in 3. day in dexamethasone experimental group | postoperative 3. day | 
| evaluation of the increase of edema in postoperative 7. day using a measuring tape in dexamethasone experimental group | preoperative edema amount was subtracted from edema amount in 7. day in dexamethasone experimental group | postoperative 7. day | 
| evaluation of the increase of edema in postoperative 1. day using a measuring tape in dexamethasone control group | preoperative edema amount was subtracted from edema amount in 1. day in dexamethasone controlgroup | postoperative 1. day | 
| evaluation of the increase of edema in postoperative 2. day using a measuring tape in dexamethasone control group | preoperative edema amount was subtracted from edema amount in 2. day in dexamethasone controlgroup | postoperative 2. day | 
| evaluation of the increase of edema in postoperative 3. day using a measuring tape in dexamethasone control group | preoperative edema amount was subtracted from edema amount in 3. day in dexamethasone controlgroup | postoperative 3. day | 
| evaluation of the increase of edema in postoperative 7. day using a measuring tape in dexamethasone control group | preoperative edema amount was subtracted from edema amount in 7. day in dexamethasone controlgroup | postoperative 7. day | 
| evaluation of the difference in increase amounts of edema between hyaluronidase experimental and hyaluronidase control groups in postoperative 1. day using a measuring tape | edema increase amount of hyaluronidase experimental group was compared with that of hyaluronidase control group in postoperative 1. day | postoperative 1. day | 
| evaluation of the difference in increase amounts of edema between hyaluronidase experimental and hyaluronidase control groups in postoperative 2. day using a measuring tape | edema increase amount of hyaluronidase experimental group was compared with that of hyaluronidase control group in postoperative 2. day | postoperative 2. day | 
| evaluation of the difference in increase amounts of edema between hyaluronidase experimental and hyaluronidase control groups in postoperative 3. day using a measuring tape | edema increase amount of hyaluronidase experimental group was compared with that of hyaluronidase control group in postoperative 3. day | postoperative 3. day | 
| evaluation of the difference in increase amounts of edema between hyaluronidase experimental and hyaluronidase control groups in postoperative 7. day using a measuring tape | edema increase amount of hyaluronidase experimental group was compared with that of hyaluronidase control group in postoperative 7. day | postoperative 7. day | 
| evaluation of the difference in increase amounts of edema between dexamethasone experimental and dexamethasone control groups in postoperative 1. day using a measuring tape | edema increase amount of dexamethasone experimental group was compared with that of dexamethasone control group in postoperative 1. day | postoperative 1. day | 
| evaluation of the difference in increase amounts of edema between dexamethasone experimental and dexamethasone control groups in postoperative 2. day using a measuring tape | edema increase amount of dexamethasone experimental group was compared with that of dexamethasone control group in postoperative 2. day | postoperative 2. day | 
| evaluation of the difference in increase amounts of edema between dexamethasone experimental and dexamethasone control groups in postoperative 3. day using a measuring tape | edema increase amount of dexamethasone experimental group was compared with that of dexamethasone control group in postoperative 3. day | postoperative 3. day | 
| evaluation of the difference in increase amounts of edema between dexamethasone experimental and dexamethasone control groups in postoperative 7. day using a measuring tape | edema increase amount of dexamethasone experimental group was compared with that of dexamethasone control group in postoperative 7. day | postoperative 7. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 1. day | pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 1. day | postoperative 1. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 2. day | pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 2. day | postoperative 2. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 3. day | pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 3. day | postoperative 3. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 4. day | pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 4. day | postoperative 4. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 5. day | pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 5. day | postoperative 5. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 6. day | pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 6. day | postoperative 6. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 7. day | pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 7. day | postoperative 7. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 1. day | pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 1. day | postoperative 1. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 2. day | pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 2. day | postoperative 2. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 3. day | pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 3. day | postoperative 3. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 4. day | pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 4. day | postoperative 4. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 5. day | pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 5. day | postoperative 5. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 6. day | pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 6. day | postoperative 6. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 7. day | pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 7. day | postoperative 7. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 1. day | pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 1. day | postoperative 1. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 2. day | pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 2. day | postoperative 2. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 3. day | pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 3. day | postoperative 3. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 4. day | pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 4. day | postoperative 4. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 5. day | pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 5. day | postoperative 5. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 6. day | pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 6. day | postoperative 6. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 7. day | pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 7. day | postoperative 7. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 1. day | pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 1. day | postoperative 1. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 2. day | pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 2. day | postoperative 2. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 3. day | pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 3. day | postoperative 3. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 4. day | pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 4. day | postoperative 4. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 5. day | pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 5. day | postoperative 5. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 6. day | pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 6. day | postoperative 6. day | 
| evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 7. day | pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 7. day | postoperative 7. day | 
| evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group preoperatively. | amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler | preoperative | 
| evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group in postoperative 1. day. | amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler | postoperative 1. day | 
| evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group in postoperative 2. day. | amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler | postoperative 2. day | 
| evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group in postoperative 3. day. | amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler | postoperative 3. day | 
| evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group in postoperative 7. day. | amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler | postoperative 7. day | 
| evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group preoperatively. | amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler | preoperative | 
| evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group in postoperative 1. day. | amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler | postoperative 1. day | 
| evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group in postoperative 2. day. | amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler | postoperative 2. day | 
| evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group in postoperative 3. day. | amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler | postoperative 3. day | 
| evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group in postoperative 7. day. | amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler | postoperative 7. day | 
| evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group preoperatively. | amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler | preoperative | 
| evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group in postoperative 1. day. | amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler | postoperative 1. day | 
| evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group in postoperative 2. day. | amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler | postoperative 2. day | 
| evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group in postoperative 3. day. | amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler | postoperative 3. day | 
| evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group in postoperative 7. day. | amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler | postoperative 7. day | 
| evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group preoperatively. | amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler | preoperative | 
| evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group in postoperative 1. day. | amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler | postoperative 1. day | 
| evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group in postoperative 2. day. | amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler | postoperative 2. day | 
| evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group in postoperative 3. day. | amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler | postoperative 3. day | 
| evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group in postoperative 7. day. | amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler | postoperative 7. day | 
| evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase experimental group preoperatively. | existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected. | preoperative | 
| evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase experimental group in postoperative 1. day. | existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected. | postoperative 1. day | 
| evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase experimental group in postoperative 2. day. | existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected. | postoperative 2. day | 
| evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase experimental group in postoperative 3. day. | existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected. | postoperative 3. day | 
| evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase experimental group in postoperative 7. day. | existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected. | postoperative 7. day | 
| evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase control group preoperatively. | existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected. | preoperative | 
| evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase control group in postoperative 1. day. | existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected. | postoperative 1. day | 
| evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase control group in postoperative 2. day. | existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected. | postoperative 2. day | 
| evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase control group in postoperative 3. day. | existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected. | postoperative 3. day | 
| evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase control group in postoperative 7. day. | existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected. | postoperative 7. day | 
| evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone experimental group preoperatively. | existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected. | preoperative | 
| evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone experimental group in postoperative 1. day | existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected. | postoperative 1. day | 
| evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone experimental group in postoperative 2. day | existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected. | postoperative 2. day | 
| evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone experimental group in postoperative 3. day | existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected. | postoperative 3. day | 
| evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone experimental group in postoperative 7. day | existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected. | postoperative 7. day | 
| evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone control group preoperatively. | existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected. | preoperatively | 
| evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone control group in postoperative 1. day | existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected. | postoperative 1. day | 
| evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone control group in postoperative 2. day | existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected. | postoperative 2. day | 
| evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone control group in postoperative 3. day | existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected. | postoperative 3. day | 
| evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone control group in postoperative 7. day | existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected. | postoperative 7. day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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postoperative edema, wisdom teeth, trismus, pain control, wound infection