Neuropathic Pain in Elderly People With Diabetes: Impact on Quality of Life and Cognition

Study Overview
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Brief Summary
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This study was set out 1) Evaluate the impact of Diabetic Peripheral Neuropathy (DPN) and DPN-P (Diabetic Peripheral Neuropathic Pain) on the overall Quality of Life (QoL) in elderly with Diabetic Mellitus (DM) and 2) Evaluate the association between cognition impairments and DM in the elderly, and the contributions of DPN and/or DPN-P

Official Title
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Neuropathic Pain in Elderly People With Diabetes: Impact on Quality of Life and Cognition

Conditions
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Diabetes Mellitus, Diabetic Peripheral Neuropathy, Cognitive Impairment, Quality of Life, Diabetic Peripheral Neuropathic Pain

Intervention / Treatment
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* Behavioral: Cambridge Neuropsychological Test Automated Battery (CANTAB)
* Other: Chinese (Hong Kong) 12-item Short-Form Health Survey (version 2)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged 50 or above Diagnosis of diabetes mellitus (Type 1 or Type 2) Exclusion Criteria: major psychiatric conditions recent cardiovascular events within the last six months blindness radiculopathy spinal cord injury, multiple sclerosis carpal tunnel syndrome trigeminal neuralgia Subjects who were incompetent in giving written consent

Ages Eligible for Study
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Minimum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| DM<br>DM without DPN (Diabetic Peripheral Neuropathy) | Behavioral: Cambridge Neuropsychological Test Automated Battery (CANTAB)<br>* Cognition using Cambridge Neuropsychological Test Automated Battery (CANTAB)<br>Other: Chinese (Hong Kong) 12-item Short-Form Health Survey (version 2)<br>* Quality of Life using Chinese (Hong Kong) 12-item Short-Form Health Survey (version 2)<br>|
| DPN<br>DM with DPN (Diabetic Peripheral Neuropathy) | Behavioral: Cambridge Neuropsychological Test Automated Battery (CANTAB)<br>* Cognition using Cambridge Neuropsychological Test Automated Battery (CANTAB)<br>Other: Chinese (Hong Kong) 12-item Short-Form Health Survey (version 2)<br>* Quality of Life using Chinese (Hong Kong) 12-item Short-Form Health Survey (version 2)<br>|
| DPN-P<br>DM with DPN-P (Diabetic Peripheral Neuropathic Pain) | Behavioral: Cambridge Neuropsychological Test Automated Battery (CANTAB)<br>* Cognition using Cambridge Neuropsychological Test Automated Battery (CANTAB)<br>Other: Chinese (Hong Kong) 12-item Short-Form Health Survey (version 2)<br>* Quality of Life using Chinese (Hong Kong) 12-item Short-Form Health Survey (version 2)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognition | Identifying cognitive affected domains by using Cambridge Neuropsychological Test Automated Battery (CANTAB) (Reaction Time : RTI, Spatial Working Memory : SWM and Executive Function : OTS) | Day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of Life: The Chinese (Hong Kong) 12-item Short-Form Health Survey version 2 | Identifying Quality of Life affected domains by using The Chinese (Hong Kong) 12-item Short-Form Health Survey version 2 | Day 1 |