The Neural Correlates of Cannabis Use

Study Overview
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Brief Summary
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The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed abstinence. This research will also examine associations between CB1R availability, neural oscillations and cognitive function.

Detailed Description
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The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed outpatient abstinence (confirmed by tracking creatinine adjusted urine THC-COOH levels). This research will also examine associations between CB1R availability, neural oscillations and cognitive function using [11-C]OMAR PET imaging and electroencephalography.

Official Title
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The Neural Correlates of Cannabis Use

Conditions
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Cannabis Dependence, Healthy

Intervention / Treatment
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* Drug: [11-C]OMAR


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Cannabis Dependent Subjects Current cannabis consumption Willing to abstain from cannabis use for four weeks Inclusion Criteria for Healthy Controls No current cannabis consumption Exclusion Criteria: MRI metal exclusions and claustrophobia Education completed is less than 12 years

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cannabis Dependent Subjects<br>Subjects who are frequent cannabis users | Drug: [11-C]OMAR<br>* The radiotracer, [11-C]OMAR will be administered at no more than 10 micrograms at the beginning of each PET scan.<br>|
| Healthy Controls<br>Subjects with no current cannabis use | Drug: [11-C]OMAR<br>* The radiotracer, [11-C]OMAR will be administered at no more than 10 micrograms at the beginning of each PET scan.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CB1R availability using [11-C]OMAR PET imaging | Change in CB1R availability (e.g. volume distribution). | Change in CB1R availability from baseline to 48 hours and 28 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in Cognition during withdrawal using a computerized battery | Changes in cognitive functions such as attention, memory, motor functioning, and processing speed. | Change in CB1R availability from baseline to 48 hours and 28 days | 
| Changes in brain rhythms measured by Electroencephalography | Changes in electroencephalographic (EEG) brain rhythms related to information processing. | Change in CB1R availability from baseline to 48 hours and 28 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Healthy Control, Cannabis, Dependence