Analysis of Retinal Nerve Fiber Layer and Macular Thickness After Congenital Cataract Surgery

Study Overview
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Brief Summary
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Congenital cataract is the main cause of form deprivation amblyopia in children. Current studies confirm that form deprivation amblyopia affects the retinal nerve fiber layer. However, there are different opinions about the effect of amblyopia on the optic nerve fiber thickness around the optic disc at home and abroad. Investigators have performed cataract extraction with IOL implantation on children with bilateral and unilateral congenital cataract. Investigators used OCT biometry to measure children's the retinal nerve fiber layer (RNFLT) and macular thickness (CMT) before and after surgery. Investigators dynamically observed changes in RNFL and CMT to explore the retinal mechanism of form deprivation amblyopia and help guide the clinical correct understanding of postoperative follow-up time.

Detailed Description
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This prospective study reviewed children with CC who were undergoing cataract extraction with IOL implantation at the Eye Hospital of Wenzhou Medical University, Hangzhou, China. bilateral and unilateral CC children were placed in Study group, while age-matched normal children were included as controls. Children who were uncooperative to complete the preoperative and postoperative examinations were excluded. All eyes were divided into 4 groups. Group 1: form deprivation amblyopia of unilateral CC, Group 2: unaffected eyes of unilateral CC, Group 3: form deprivation amblyopia of bilateral CC, Group 4: normal eyes of normal children. The preoperative and postoperative data including sex, age at surgery, 7 position of RNFLT and CMT were collected. All surgeries were performed by the same surgeon (Y.E.Z.) under general anesthesia. Investigators used OCT biometry to measure participants' the retinal nerve fiber layer (RNFLT) and macular thickness (CMT) before surgery and 1 week, 1 month, 3 months, and 6 months and 1 year after surgery, and compared with age-matched normal children.

Official Title
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Analysis of Retinal Nerve Fiber Layer and Macular Thickness After Congenital Cataract Surgery

Conditions
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Congenital Cataract

Intervention / Treatment
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* Procedure: cataract surgery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: congenital cataract Exclusion Criteria: incooperative to complete the preoperative and postoperative examinations

Ages Eligible for Study
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Minimum Age: 1 Month
Maximum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: the RNFLT and CMT<br>the retinal nerve fiber layer (RNFLT) and macular thickness (CMT) | Procedure: cataract surgery<br>* To measure the RNFLT and CMT in congenital cataracts before and after the cataract extraction with IOL implantation surgery<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| RNFLT | the retinal nerve fiber layer thickness (RNFLT)measured by OCT biometry (Units :um) | 1 year | 
| CMT | the macular thickness (CMT) measured by OCT biometry (Units :um) | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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RNFLT