GBR With Ptfe With Bovine Bone With and Without Autogenous

Study Overview
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Brief Summary
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Ridge Augmentation in Atrophic Anterior Maxillary Ridges with a Titanium Reinforced Polytetraflouroethelene Membrane and Anorganic Bovine Bone-Derived Mineral in intervention group and Anorganic Bovine Bone-Derived Mineralwith Particulated Autogenous Bone Chips in control group. CBCT will be done before surgery, immediate after surgery and 6 month to compare the bone gain in mm. Bone sample will be collected during exposure after 6 month of surgery by trephine bur to assess the bone quality through histo-morphometric analysis in order to determine the size, shape and orientation of the bony trabeculae, the size and porosity of the bony cortex in addition to the new bone/ bone substitute ratio 1ry outcome: Amount of bone gain will be measured using linear measurements from CBCT immediate after surgery and after 6 month. 2ry outcome: a bone sample will be collected and analyzed under histo-morphometric analysis.

Official Title
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Ridge Augmentation in Atrophic Anterior Maxillary Ridges With a Titanium Reinforced Polytetraflouroethelene Membrane and Anorganic Bovine Bone-Derived Mineral With and Without Particulated Autogenous Bone Chips

Conditions
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Atrophied Anterior Maxillary Ridges

Intervention / Treatment
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* Other: Geistlich Bio-Oss® bovine bone alone


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • Patients with atrophied anterior maxillary ridge area. Age: 18 years and older. Both sexes. No intraoral soft and hard tissue pathology. No systemic condition that contraindicate bone augmentation Exclusion Criteria: • Heavy smokers more than 20 cigarettes per day.(32) Patients with systemic disease that may affect normal healing. Psychiatric problems. Disorders to bone augmentation are related to history of radiation therapy to the head and neck neoplasia. Pregnant or nursing women. Patients with uncontrolled diabetes mellitus, rheumatoid arthritis or osteoporosis. Patient with previous history of radiotherapy.

Ages Eligible for Study
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Minimum Age: 16 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: intervention<br>using a bio-oss bovine bone alone | Other: Geistlich Bio-Oss® bovine bone alone<br>* Ridge augmentation by titanium reinforced polytetraflouroethelene membrane and anorganic bovine bone derived mineral alone<br>|
| Active Comparator: control<br>using a bio-oss bovine bone with autogenous bone ratio 1:1 | Other: Geistlich Bio-Oss® bovine bone alone<br>* Ridge augmentation by titanium reinforced polytetraflouroethelene membrane and anorganic bovine bone derived mineral alone<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Amount of bone gain (height and width in mm) | will be measured using linear measurements from CBCT | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| a bone sample will be collected and analyzed under histo-morphometric analysis. (no of bone cells in cubic mm) | a bone sample will be collected and analyzed under histo-morphometric analysis. | 6 months |