Incidence and Risk Factors of Symptomatic Epidural Hematoma After Cervical Spine Surgery

Study Overview
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Brief Summary
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The incidence and correlation of symptomatic epidural hematomas after cervical spine surgery was reviewed and analyzed, then it will provide reference to avoid the occurrence of this complication for the future clinical work.

Detailed Description
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43 patients with symptomatic epidural hematoma after cervical spine surgery were enrolled in the Peking University Third hospital from January, 2009 to February, 2017. 86 patients without symptomatic epidural hematoma after cervical spine surgery during the same period were randomly selected as the control group. Demographic information (including gender, age, previous history, smoking history, etc.)，disease parameters (diagnosis, mJOA(modified Japanese Orthopaedics association) score, NDI(neck disability index) score)，laboratory and imaging parameters (including platelet, coagulation function, albumin, and OPLL)，segments，treatment parameters (surgical method, number of surgical segments, operative time, intraoperative blood loss, anesthesia time, whether to use implants) and postoperative conditions (including the time of hematoma occurrence, diagnostic method, emergency debridement operation time, patient improvement before and after debridement) were collected.Firstly, risk factors for symptomatic epidural hematoma after cervical surgery were selected by univariate analysis,then independent risk factors were screened by multiple Logistic regression analysis.

Official Title
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Incidence and Risk Factors of Symptomatic Epidural Hematoma After Cervical Spine Surgery:a Retrospective Study

Conditions
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Symptomatic Epidural Hematoma After Cervical Spine Surgery

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with clinically and radiologically confirmed cervical spondylosis. Cervical spine surgery was performed in our hospital Exclusion Criteria: Cervical trauma combined with fracture and dislocation. Cervical cancer. Cervical spine infection Upper cervical spine surgery alone
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| The hematoma group<br>with symptomatic epidural hematoma after surgery | |
| The control group<br>without symptomatic epidural hematoma after surgery | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| VAS(visual analogue pain scale) | visual analogue pain scale, to evaluate patients' pain, form 0 to 10. more scores means more pain | 3 months after surgery | 
| Frankel score | Postoperative Neurological Function，From A to E. Score A means complete paralyzed and E means no paralyzed | 3 months after surgery | 
| mJOA | Postoperative Neurological Function, modified Japanese orthopaedics association, From 0 to 17 scores. More scores mean better recovery after surgery. Score 0 means the most severe symptoms. | 3 months after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| whether patients occur hematoma after surgery | whether patients occur hematoma after surgery | From post operation immediately till 3 months after surgery | 
| whether patients need emergency debridement | whether patients need emergency debridement caused by hematoma | From post operation immediately till 3 months after surgery | 
| the place that occur hematoma | the place that occur hematoma, to locate the place of hematoma from post operation immediately till 3 months after surgery | From post operation immediately till 3 months after surgery | 
| postoperative neurological recovery after treatment of hematoma | To record neurological recovery after treatment of hematoma from post operation immediately till 3 months after surgery, use modified Japanese Orthopaedics association | From post operation immediately till 3 months after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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epidural hematoma, cervical spine surgery, Risk factors