linjc16/ctgov huggingface dataset:
Role of Indoor Pollutants on House Dust Mite Allergic Asthma

Study Overview
=================
Brief Summary
-----------------
It seems that the aldehydes and NO2, at the levels found indoor, could be the aggravating factors for an allergic response. However this effect has not been demonstrated. The investigators plan to study the effect of exposure to standard doses of these pollutants on the bronchial reactivity as measured by bronchial challenge tests with dust mite extract in volunteers asthmatic, allergic to house dust mite.

Official Title
-----------------
Aldehyde and Nitrogen Dioxide at Homes: Measurement of the Exposure and Their Role on Allergic Asthma

Conditions
-----------------
Allergic Asthma, Allergy to House Dust Mite

Intervention / Treatment
-----------------
* Other: Formaldehyde and NO2 (Exposure to indoor pollutants)
* Other: Placebo (Exposure to indoor pollutants)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: M/F 18-50 years of age History of intermittent HDM allergic asthma-FEV1 > 80% Non smokers or smokers with smoking < 10 PY Exclusion criteria: Persistent asthma and FEV1<80% Allergic to pets and pets at home

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: NO2<br>NO2 400 µg/m3 | Other: Formaldehyde and NO2 (Exposure to indoor pollutants)<br>* Exposure to indoor pollutants (Formaldehyde and NO2) in a randomized way, followed by bronchial challenge test with house dust mite extract.<br>|
| Experimental: Formaldehyde<br>Formaldehyde 100 µg/m3 | Other: Formaldehyde and NO2 (Exposure to indoor pollutants)<br>* Exposure to indoor pollutants (Formaldehyde and NO2) in a randomized way, followed by bronchial challenge test with house dust mite extract.<br>|
| Experimental: NO2 + Formaldehyde<br>mixture of Formaldehyde and NO2 | Other: Formaldehyde and NO2 (Exposure to indoor pollutants)<br>* Exposure to indoor pollutants (Formaldehyde and NO2) in a randomized way, followed by bronchial challenge test with house dust mite extract.<br>|
| Placebo Comparator: Placebo<br> | Other: Placebo (Exposure to indoor pollutants)<br>* Exposure to indoor pollutants (placebo) in a randomized way, followed by bronchial challenge test with house dust mite extract.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Indoor pollutants
Prospective Validation of the OHI Index

Study Overview
=================
Brief Summary
-----------------
Hemophagocytic lymphohistiocytosis (HLH) associated with hematologic malignancies (HM-HLH) is a syndrome with an abysmal prognosis (10-30% 5 years overall survival). We have recently established an improved diagnostic and prognostic index for HM-HLH, termed the Optimized HLH Inflammatory (OHI) index. The OHI index is comprised of the combined elevation of soluble CD25 (sCD25) > 3,900 U/mL and ferritin >1,000 ng/mL . However, the true incidence and outcomes of HLH/OHI+ in an unselected cohort are unknown and so is the mechanism of HM-HLH.

Detailed Description
-----------------
The investigators will enroll patients with new/transformed hematologic malignancies. We will follow the patients until the end of the study, report their survival at one year and examine their prognosis.

Official Title
-----------------
A Prospective Study to Validate the Prognostic Power of the Optimized HLH Inflammatory (OHI) Index

Conditions
-----------------
HLH, Hemophagocytic Lymphohistiocytoses, Hemophagocytic Syndrome, Hematologic Malignancy, Hematologic Neoplasms

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with hematologic malignancies At least 18 years old Exclusion Criteria: Prior recent treatment (chemotherapy/ other cytoreductive therapies in the last month)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| OHI+ patients<br>Adult patients with hematologic malignancies that have sCD25>3,900 U/mL and ferritin >1,000 ng/mL | |
| OHI- patients<br>Adult patients with hematologic malignancies, with sCD25>3,900 U/mL and/or ferritin < 1,000 ng/mL | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To assess 365 days mortality of OHI+ and OHI- patients | We will use Kaplan-Meier curves to compare survival between OHI+ and OHI- patients | Mortality rate one year from OHI assessment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To determine the incidence of OHI+ patients in our cohort | We will assess the incidence of OHI+ within our cohort (OHI+/total patients enrolled) | We will assess the incidence after three years of enrollment |
Hospital-based Surveillance of Rotavirus Gastroenteritis in Young Taiwanese Children

Study Overview
=================
Brief Summary
-----------------
Rotavirus remains among the leading causes of pediatric gastroenteritis requiring hospitalization in the world. Surveillance studies revealed that more than 90% of the global circulating rotavirus strains were predominated by several major genotypes. Clinical trials and post-marketing studies have demonstrated that the currently available rotavirus vaccine can provide sufficient protection against strains of the prevalent genotypes. However, the emerging strains with new genotypes were increasingly reported in the past decade, an ongoing surveillance of the strain changes is needed in the regions where the pediatric population is either fully or partly immunized. In this project, the investigators will setup a hospital-based gastroenteritis surveillance network by incorporating 8 major hospitals in northern, central, southern and eastern Taiwan. From 2013 to 2015, children aged 5 years or younger hospitalized to one of the 8 sentinel hospitals due to acute gastroenteritis will be screened for rotavirus infection, and viral proteins 7 [VP7] (G type) and viral proteins 4 [VP4] (P type) genotypes of rotavirus will be determined for each infected case. The demographics and clinical manifestations of study subjects will also be collected and analyzed. Through this project, the investigators will be able to detect emerging genotypes of rotavirus and delineate the strain distribution during the two years of study in Taiwan. The investigators can also have more comprehensive understanding of the epidemiology of rotavirus regarding to the incidence, disease characteristics, temporal and geographic variations of severe rotavirus gastroenteritis in Taiwanese children. Results from this project will provide valuable information for future implementation of mass immunization against rotavirus in Taiwan.

Official Title
-----------------
Hospital-based Surveillance of Severe Rotavirus Gastroenteritis and Diversity of Circulating Rotavirus Strains in Young Taiwanese Children

Conditions
-----------------
Rotavirus Gastroenteritis, Young Taiwanese Children

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: aged less than 60 months, hospitalized in 1 of the 8 hospitals, having diarrhea not caused by any known underlying diseases. Exclusion Criteria: No

Ages Eligible for Study
-----------------
Maximum Age: 5 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| monitor the strain diversity of rotavirus in Taiwan | monitor the strain diversity of rotavirus in Taiwan, including the individual serotype prevalence and emerging genotypes | 4 years |
Changes in Body- and Liver-composition During Low Calorie Diet in Morbidly Obese

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine what changes occur in body- and liver-composition during four weeks of low calorie diet in morbidly obese females

Detailed Description
-----------------
Preoperative weight loss prior to laparoscopic gastric bypass is desirable as this reduces liver volume and thus facilitates the visualization of the gastro-esophageal junction. Weight loss is often achieved through low-calorie diet (LCD); however the ideal duration of LCD treatment is unknown. Morbidly obese female patients awaiting laparoscopic gastric bypass are recruited. They are, as all our patients, treated during four weeks with LCD to achieve a decrease in liver size. During this period they are examined on day 0, 3, 7, 14 and 28 after commencing LCD. At each evaluation, body composition is assessed through bioelectric impedance analysis (BIA), liver volume and intrahepatic fat through magnetic resonance imaging. A questionnaire regarding quality of life and LCD-related symptoms is administered as well. At surgery two samples of subcutaneous fat and one sample of omental fat is taken. We do not assign patients to different treatments, instead all are treated similarly according to our routine preoperative regimen.

Official Title
-----------------
Changes in Body- and Liver-composition During Low Calorie Diet in Morbidly Obese

Conditions
-----------------
Obesity

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Awaiting laparoscopic gastric bypass Residing near Uppsala Exclusion Criteria: Weight above 140 kg Metal implants such as pacemaker or intracerebral clips Failure to understand or comply with study protocol

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Liver volume |  | From baseline to after four weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Composition of body fat in subcutaneous and omental fat |  | At surgery | 
| Changes in body composition |  | Baseline to 4 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Liver volume, Gastric bypass, Magnetic resonance imaging
Descriptive Study of Trampoline Accidents in the Pediatric Emergency Department of Rennes

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to compare trauma related to others sport to trauma due to trampoline in pediatric emergencies of Rennes.

Detailed Description
-----------------
Trampoline accidents are increasing since a few years. In Rennes hospital, pediatric emergencies are experiencing a subjective increase in admissions for trampoline trauma with increasingly early ages and severe trauma. The aim of this study is to compare trauma related to others sport to trauma due to trampoline in pediatric emergencies of Rennes. In parallel, retrospective data analysis will be performed on the same data during the year 2008, to compare with a period before the explosion of trampoline sales.

Official Title
-----------------
Descriptive Study of Trampoline Accidents in the Pediatric Emergency Department of Rennes

Conditions
-----------------
Trauma, Emergencies, Child, Only

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Child from 2 to 16 years old Childs admitted in emergencies unit for a trauma Parents not opposed in their child's participation to the study Exclusion Criteria: Child under 2 years old (before learning to walk) Single wounds and head injuries not related to sports activities (Fall from a bed or from its height, simple wound with sharp objects)

Ages Eligible for Study
-----------------
Minimum Age: 2 Years
Maximum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Trampoline group<br>Child patients with trauma due to trampoline from june 2016 to december 2016 consulting in emergencies unit of Rennes' hospital | |
| Control group<br>Child patients with trauma related to sport from june 2016 to december 2016 consulting in emergencies unit of Rennes' hospital | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Types of trauma related to trampoline compared to trauma related to others sport in pediatric emergencies of Rennes. | Types of trauma related to trampoline compared to trauma related to others sport in pediatric emergencies of Rennes. | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Arguments for preventive management in the general practitioner | Arguments for preventive management in the general practitioner | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
trampoline
Repetitive Transcranial Magnetic Stimulation of the Posterior Parietal Cortex in Patients Suffering From Gilles de la Tourette Syndrome

Study Overview
=================
Brief Summary
-----------------
Repetitive transcranial stimulation (rTMS) of the posterior parietal cortex will be applied daily over five days in adult Gilles de la Tourette patients. This approach aims at reducing premonitory sensations believed to induce tics. Patients will be randomized to an active or placebo (sham) group in a crossover design.

Official Title
-----------------
Repetitive Transcranial Magnetic Stimulation of the Posterior Parietal Cortex in Patients Suffering From Gilles de la Tourette Syndrome

Conditions
-----------------
Gilles de la Tourette Syndrome, Tics

Intervention / Treatment
-----------------
* Device: rTMS
* Device: Sham rTMS


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Gilles de la Tourette syndrome as defined by DSM IV-R Yale Global Tics Severity Scale (YGTSS) score between 30 et 60 Premonitory sensations ( urge to move ) Affiliated to the French social security regime Ability to give informed consent Exclusion Criteria: rTMS : epilepsy, craniotomy scar, pacemaker or neural stimulator, metal implants or foreign bodies, claustrophobia, pregnancy Cognitive impairment (MMS ≤ 24/30) Axis I disorders according to DSM IV-R : psychosis or history of psychosis, bipolar illness, major depressive disorder, addictions (except to nicotine) Impulse control disorders Other chronic debilitating illnesses Unability to give informed consent Participation in another clinical trial

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Stimulation<br>Repetitive transcranial stimulation of the posterior parietal cortex | Device: rTMS<br>* Repetitive transcranial stimulation of the posterior parietal cortex<br>|
| Sham Comparator: Sham stimulation<br> | Device: Sham rTMS<br>* Repetitive transcranial stimulation of the posterior parietal cortex<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Yale global tic severity scale (YTGSS) |  | 3 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Gilles de la Tourette syndrome, Tics, Transcranial magnetic stimulation
Drainage of Tuberculous Pleural Effusions

Study Overview
=================
Brief Summary
-----------------
Tuberculous (TB) pleurisy can cause clinical symptoms and pleural fibrosis with resultant residual pleural thickening (RPT). Therapeutic thoracentesis or initial complete drainage in addition to anti-TB drugs have been tried to rapidly relieve dyspnea caused by effusion and to decrease the occurrence of RPT. However, contradictory results are reported without clear reasons. The researchers' hypothesis is that, in addition to anti-TB medications, early effective evacuation of inflammatory exudates with or without fibrinolytic agents may hasten resolution of pleural effusion, reduce the occurrence of RPT and finally improve long-term functional outcome in patients with TB pleurisy.

Official Title
-----------------
Drainage of Tuberculous Pleural Effusions

Conditions
-----------------
Tuberculous Pleurisy

Intervention / Treatment
-----------------
* Procedure: Pigtail drainage


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of tuberculous pleurisy Exclusion Criteria: History of invasive procedures directed into the pleural cavity Recent severe trauma, hemorrhage, or stroke; bleeding disorder or anticoagulant therapy Use of streptokinase in the previous 2 years Lack of clinical symptoms caused by effusions

Ages Eligible for Study
-----------------
Minimum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Pigtail drainage|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Chest radiography, daily monitoring of the volume of fluid drained, the time needed for resolution of fever and dyspnea, and total amounts of fluid drained, and the length of chest drainage and hospitalization |  | baseline, daily after treatment within admission | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Chest radiography and pulmonary function testing with spirometry |  | At discharge and at 2, 4, 6, and 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
loculated pleural effusion, pigtail drainage, pleural effusion, pleural thickening, tuberculosis
Early Active Rehabilitation After Arthroscopic Rotator Cuff Repair

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to compare two different rehabilitation protocols after arthroscopic rotator cuff surgery.

Official Title
-----------------
Early Active Rehabilitation After Arthroscopic Rotator Cuff Repair: A Prospective Randomized Pilot Study

Conditions
-----------------
Full Thickness Rotator Cuff Tear

Intervention / Treatment
-----------------
* Other: early isometric loading after rotator cuff surgery
* Other: passive motion after rotator cuff surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: surgery of the rotator cuff after full thickness tear informed consent understanding german language Exclusion Criteria: previous surgery of the shoulder neurological or systemic diseases with impairment of shoulder function

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Primary Active<br>Early postoperative isometric activation of the rotator cuff | Other: early isometric loading after rotator cuff surgery<br> <br> |
| Active Comparator: Primary Passive<br>Standard postoperative passive movement rehabilitation protocol | Other: passive motion after rotator cuff surgery<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of Constant Murley Score | Timepoints: Before surgery; 6, 12, 24 weeks after surgery | up to 24 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of DASH Score | Timepoints Before surgery; 6, 12, 24 weeks after surgery | up to 24 weeks | 
| Change of Active range of Motion (Flexion, Extension, Abduction, Internal Rotation, External Rotation) | Timepoints: Before surgery; 6, 12, 24 weeks after surgery; Range of movement is measured by handheld goniometer | up to 24 weeks | 
| Change of Pain (max; average; rest) | Timepoints: Before surgery; 6, 12, 24 weeks after surgery; Pain is measured by Visual Analogue Scale (0-100mm) | up to 24 weeks | 
| Change of Strength (abduction; external Rotation) | Timepoints: Before surgery; 6, 12, 24 weeks after surgery; Measurement of Strength is evaluated using a BTE Simulator II Dynamometer (Peak torque in N). | up to 24 weeks |