Comparison of MR Elastography Methods Without and With Compressed Sensing

Study Overview
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Brief Summary
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In this research study, the investigators will compare the liver stiffness results obtained from the current Magnetic Resonance Imaging (MRI) method to liver stiffness results obtained from a method that uses faster imaging techniques.

Detailed Description
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MR elastography is increasingly used to assess liver stiffness in pediatric and adult patients with chronic liver diseases. While numerous tissue abnormalities can affect liver stiffness, liver stiffness measured by MR elastography is most often used to predict and quantify liver fibrosis. Conventional MR elastography techniques require multiple breath-holds that are 12-20 seconds in length. In the pediatric population, reliable breath-holding >10 seconds can be challenging. Recently, compressed sensing has become available as a method for accelerating image data acquisition, and thus shortening breath-holds.

Official Title
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Comparison of MR Elastography Methods Without and With Compressed Sensing

Conditions
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Liver Diseases

Intervention / Treatment
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* Device: Magnetic Resonance Elastography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult volunteers ≥18 years of age Ability to tolerate 30 minutes in an MRI scanner. Nothing to eat or drink for 4 hours prior to the MRI scan Exclusion Criteria: No contraindication to MR imaging (e.g., implanted non-MRI compatible device) Known or suspected pregnancy. Female subjects of child bearing potential will undergo a urine pregnancy test prior to imaging.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Magnetic Resonance Elastography|The investigators plan to prospectively assess the agreement of liver stiffness measurements obtained using standard of care MR elastography techniques vs. MR elastography with varying amounts of imaging acceleration using compressed sensing in adult volunteers|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Standard Magnetic Resonance Elastography versus Elastography with Compressed Sensing (x1.5) | Four MR elastography images through the mid liver will be obtained using standard MR elastography and MR elastography with 1.5 times the amount of standard Sensing applied. Correlation Coefficient will be determined for resulting elastography data. | 30 minutes | 
| Standard Magnetic Resonance Elastography versus Elastography with Compressed Sensing (x2) | Four MR elastography images through the mid liver will be obtained using standard MR elastography and MR elastography with 2 times the amount of standard sensing applied. correlation coefficient will be determined for resulting elastography data. | 30 minutes | 
| Standard Magnetic Resonance Elastography versus Elastography with Compressed Sensing (x3) | Four MR elastography images through the mid liver will be obtained using standard MR elastography and MR elastography with 3 times the amount of standard Sensing applied. Correlation coefficient will be determined for resulting elastography data. | 30 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Standard Magnetic Resonance Elastography versus respiratory triggered Magnetic Resonance Elastography. | Four MR elastography images through the mid liver will be obtained using standard MR elastography and MR elastography acquired using respiratory triggered Gradient Recalled Elastography. Correlation coefficient will be determined for resulting elastography data. | 30 minutes | 
| Standard Magnetic Resonance Elastography versus navigated triggered Magnetic Resonance Elastography. | Four MR elastography images through the mid liver will be obtained using standard MR elastography and MR elastography acquired using navigated triggered Gradient Recalled Elastography. Correlation coefficient will be determined for resulting elastography data. | 30 minutes |