Enhanced Diagnostics for Early Detection of Atrial Fibrillation

Study Overview
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Brief Summary
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Paroxysmal atrial fibrillation can only be diagnosed during episodes when the arrhythmia is present. The investigators hypothesize that the activation of the atrial myocardium resulting in the p-wave of the ecg should display abnormalities in diseased atria which are vulnerable for AF.

Detailed Description
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In the first part of this trial different diagnostic techniques to detect arrythmogenic substrates of atrial fibrillation will be tested. If suitable parameters can be identified, a follow up trial to identify patients at risk for AF will be conducted before a stroke happens. Parameters tested are Electrophysiological differences between patients with paroxysmal AF and no history of AF Vascular Stiffness detected by an iPhone app All patients will undergo a cardiogoniometrie and a pulse wave analysis with an iPhone. Each exam takes 5 minutes.

Official Title
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Enhanced Diagnostics for Early Detection of Atrial Fibrillation - DETECT AF Trial

Conditions
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Atrial Fibrillation

Intervention / Treatment
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* Device: ECG


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: paroxysmal atrial fibrillation in sinus rhythm at presentation Exclusion Criteria: acute cerebral trauma antiarrhythmic medication

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Paroxysmal Af<br>No Intervention is planned. All patients receive a 5 Minute ECG and have their pulse recordes by an iPhone. | Device: ECG<br>* Patients receive a 5 Minute ECG recording and have their pulse recorded by an iPhone.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Beat to beat variation of the electrical activation vector of the atrium | Test if the beat to beat Variation of the electrical activation of the atrium differentiates between the group of patients with paroxysmal AF and no AF in history. | Once during the exam (baseline) - No further follow up planned | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Averaged slope of pressure-curve | Test if the steepness of the slope of the pressure curve recorded with the iPhone differs between the two Groups. | Once during exam (5min, baseline) - No further follow up planned | 
| Averaged slope of pressure-curve | Test if the steepness of the slope of the pressure curve recorded with the iPhone correlates with cardiovascular risk factors. | Once during exam (5min, baseline) - No further follow up planned | 
| Heart rate variability | Test if heart rate variability recorded with the iPhone differs between the two Groups. | Once during exam (5min, baseline) - No further follow up planned | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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atrial fibrillation, atrial electrophysiology, stroke, vascular stiffness