Longitudinal Study on the Influence of Iodine Nutrition Status on Thyroid Function of Childbearing Age Women During Pregnancy and 6 Weeks Postpartum

Study Overview
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Brief Summary
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The goal of this observational study is to provide a reference for formulating individual appropriate iodine intake programs for women during pregnancy and postpartum and improving the monitoring and evaluation system of maternal iodine nutrition status. The main questions it aims to answer are: To analyse the longitudinal changes of urinary iodine, urinary iodine/creatinine ratio, thyroid function and related factors in different periods of early, middle, late pregnancy and 6 weeks postpartum in Beijing area. To explore the relationship between iodine nutrition status and the changes of thyroid function and to further clarify the effect of iodine nutrition status on thyroid function of women of childbearing age during pregnancy and postpartum in combination with dietary intake of iodine questionnaire. Participants will be detected there thyroid function, the level of median urinary iodine and urinary iodine/creatinine. Researchers will compare healthy women of childbearing age served as the control group in the same period.

Official Title
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Longitudinal Study on the Influence of Iodine Nutrition Status on Thyroid Function of Childbearing Age Women During Pregnancy and 6 Weeks Postpartum

Conditions
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Thyroid Function, Iodine Nutrition Status

Intervention / Treatment
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* Other: iodine nutrition status


Participation Criteria
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Eligibility Criteria
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8-12 weeks healthy maternal: Inclusion Criteria: primigravida no chronic hypertension, thromboembolic disease, severe gastrointestinal, cardiopulmonary and liver diseases before pregnancy no systemic lupus erythematosus, rheumatic diseases and other connective tissue diseases or immune diseases before pregnancy no adrenocortical hyperplasia, pituitary endocrine diseases and other diseases before pregnancy Exclusion Criteria: multiple pregnancies and multigravida a history of type I or type II diabetes before pregnancy a clear history of thyroid diseases before pregnancy taking drugs that affect thyroid function and/or blood sugar before or during early pregnancy Healthy women of childbearing age: Inclusion Criteria: 20-40 years old no chronic hypertension, thromboembolic disease, severe gastrointestinal, cardiopulmonary and liver diseases no systemic lupus erythematosus, rheumatic diseases and other connective tissue diseases or immune diseases no adrenocortical hyperplasia, pituitary endocrine diseases and other diseases Exclusion Criteria: a history of type I or type II diabetes a clear history of thyroid diseases taking drugs that affect thyroid function and/or blood sugar
Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| pregnancy and lactation period women<br> | Other: iodine nutrition status<br>* iodine nutrition status<br>|
| healthy women of childbearing age<br> | Other: iodine nutrition status<br>* iodine nutrition status<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Data of pregnant women in the early trimester of pregnancy | detect the level of serum TSH, FT4, TPOAb, TGAb and the level of median urinary iodine and urinary iodine/creatinine | Any day between weeks 8 and 12 of gestation | 
| Data of pregnant women in the middle trimester of pregnancy | detect the level of serum TSH, FT4, TPOAb, TGAb and the level of median urinary | Any day between weeks 24 and 28 of gestation | 
| Data of pregnant women in the third trimester of pregnancy | detect the level of serum TSH, FT4, TPOAb, TGAb and the level of median urinary | Any day between weeks 36 of gestation to the day before parturition | 
| Data of postpartum women | detect the level of serum TSH, FT4, TPOAb, TGAb and the level of median urinary | 6 weeks after parturition |