Early Stage Retinal Abnormalities in Type 1 Diabetes, Screened With OCT Angiography.

Study Overview
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Brief Summary
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The improvement of imaging techniques in ophthalmology has made it possible to carry out a precise non-invasive study of the retinal microvascular network and to detect early abnormalities in retinal disorders. The presence of such early retinal abnormalities remains poorly known during type 1 diabetes and may be detected with OCT-angiography. Furthermore, the association with glycemic variability, likely to have deleterious effects on microvessels, has never been studied.

Official Title
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Early Stage Retinal Abnormalities in Type 1 Diabetes, Screened With OCT Angiography.

Conditions
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Type 1 Diabetes Patients

Intervention / Treatment
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* Procedure: Retinal imaging assessment
* Procedure: blood glucose holter


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: For the patient group Patient who has given consent Type 1 diabetic patient, no retinopathy For the healthy control group Patient who has given consent Non-diabetic patient For dyslipidemic control group: Person who has given consent Person with familial dyslipidemia Exclusion Criteria: For the patient group Presence of diabetic retinopathy Protected patient: Minor patient Pregnant, parturient or breastfeeding woman Patient under legal protection (guardianship, curatorship, court decision) Patient unable to express consent Person not affiliated to a health insurance scheme For the healthy control group Ophthalmological history (vascular and degenerative macular conditions) Protected patient: Minor patient Pregnant, parturient or breastfeeding woman Patient under legal protection (guardianship, curatorship, court decision) Patient unable to express consent Person not affiliated to a social security scheme For dyslipidemic control group: Ophthalmological history (vascular and degenerative macular conditions) Protected patient: Minor patient Pregnant, parturient or breastfeeding woman Patient under legal protection (guardianship, curatorship, court decision) Patient unable to express consent Person not affiliated to a social security scheme

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients<br>type 1 diabetes patients | Procedure: Retinal imaging assessment<br>* OCT-angiography Automated measurement program: size of the avascular zone and perifoveolar vascular density of the superficial capillary plexus Eye fundus photography: macular image Measurement of the fractal dimension of the retinal foveolar retina from photographs of the fundus<br>Procedure: blood glucose holter<br>* for 40 subjects, implantation of a blood glucose holter monitor for 7 days<br>|
| Healthy controls<br>non diabetic control subjects of the same age | Procedure: Retinal imaging assessment<br>* OCT-angiography Automated measurement program: size of the avascular zone and perifoveolar vascular density of the superficial capillary plexus Eye fundus photography: macular image Measurement of the fractal dimension of the retinal foveolar retina from photographs of the fundus<br>|
| Dyslipidemic controls<br>non-diabetic control participants with familial dyslipidemia | Procedure: Retinal imaging assessment<br>* OCT-angiography Automated measurement program: size of the avascular zone and perifoveolar vascular density of the superficial capillary plexus Eye fundus photography: macular image Measurement of the fractal dimension of the retinal foveolar retina from photographs of the fundus<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| surface of the central retinal avascular zone | measurement of superficial capillary plexus | inclusion |