Measles, Mumps, and Rubella (MMR) Immunity in College Students

Study Overview
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Brief Summary
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This study will lay the foundation for determining the underlying reasons for lack of immunity to mumps that led to the 2006 mumps outbreak on college campuses in the Mid West, and it will assess the potential for similar outbreaks of measles and rubella. A total of 70 to 80 college students (age 18 to 22) on the Emory campus (or nearby college campuses or the community) will be assessed for antibodies to measles, mumps or rubella by drawing a one-time blood sample. Their medical records will be verified for documentation of immunization with MMR vaccine prior to enrollment in the study. If a study volunteer is found to not have MMR immunity, they will be offered an MMR-II vaccine. For this group, additional blood specimens will be obtained.

Detailed Description
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No additional description needed.

Official Title
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Persistence of Humoral and Cellular Immune Responses Following Age-appropriate Vaccination With the MMR Vaccine

Conditions
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Measles, Mumps, Rubella

Intervention / Treatment
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* Biological: MMR vaccine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Ability and willing to provide an informed consent Documented receipt of MMR-II vaccination in childhood Not pregnant Exclusion Criteria No history of HIV infection. Immunocompromised health status due to HIV infection, cancer, diabetes, liver, lung or kidney diseases, autoimmune diseases, history of splenectomy. Use of immunosuppressive medications within last 2 to 3 months (oral or parenteral corticosteroids or cytotoxic medications) Medical conditions that require the use of immunosuppressive medications Received blood or blood products within the last 30 days Any vaccines received in the last 30 days

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 24 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| cross-sectional<br>College-aged students who were immunized with MMR. | Biological: MMR vaccine<br>* People with no antibodies to either mumps, measles and rubella will be offered the MMR vaccine (they may choose to or choose not to receive the MMR vaccine)<br>* Other names: No other names;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Levels of mumps antibody and levels of memory B and T cell responses | Cross sectional measurement of antibodies to mumps. measles or rubella | Day 1 for all participants except for those who receive MMR vaccine, there will be additional outcome measures on Day 0, 7, 14 and 28 post-vaccination. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determine proportion of college-aged students who are seronegative for mumps | Cross-sectional measurement of antibodies to mumps, measles and rubella | outcome measurement on Day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Mumps, Immunity, Vaccine, Mumps antibodies, Mumps immunity