The Study About the Selection of Time for Retreatment of Helicobacter Pylori After Eradication Failure

Study Overview
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Brief Summary
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The patients who accepted the quadruple eradication program of the helicobacter pylori but failed to eradicate helicobacter pylori will be assessed the most suitable re-eradication time of helicobacter pylori.

Detailed Description
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Helicobacter pylori (HP) infection is a common global infectious disease, which is an important cause of chronic gastritis, peptic ulcer and gastric cancer. At present, due to the non-standard Helicobacter pylori eradication program in clinical work, poor patient compliance and other reasons, the phenomenon of HP eradication treatment failure is more and more common. However, there is still no conclusion on the most appropriate time for remedial treatment inpatients with Hp eradication failure.

Official Title
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The Study About the Selection of Time for Retreatment of Helicobacter Pylori After Eradication Failure

Conditions
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Helicobacter Pylori Infection

Intervention / Treatment
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* Drug: Amoxicillin,Furazolidone
* Drug: Amoxicillin,Levofloxacin
* Drug: Tetracycline,Furazolidone


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged 18-70 with H. pylori infection. Patients with previous Helicobacter pylori eradication. Exclusion Criteria: Patients treated with H2-receptor antagonist, PPI, bismuth and antibioticsin the previous 4 weeks. Patients with gastrectomy, acute GI bleeding and advanced gastric cancer. Patients with known or suspected allergy to study medications. Currently pregnant or lactating. Inability to provide informed consent and other situations that couldinterfere with the examination or therapeutic protocol.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Amoxicillin-Furazolidone-containing quadruple group<br>Patients in amoxicillin-furazolidone-containing quadruple group will receive esomeprazole (Nexium) 40mg po bid(or vonoprazan fumarate 20mg po bid), amoxicillin1000mg po bid, bismuth potassium citrate(Lizhudele) 220mg po bid, and furazolidone (Liteling) 100mg po bid for 14d. | Drug: Amoxicillin,Furazolidone<br>* Amoxicillin-Furazolidone-containing quadruple group<br>|
| Amoxicillin-Levofloxacin-containing quadruple group<br>Patients in amoxicillin-Levofloxacin-containing quadruple group will receive esomeprazole (Nexium) 40mg po bid(or vonoprazan fumarate 20mg po bid), amoxicillin1000mg po bid, bismuth potassium citrate(Lizhudele) 220mg po bid, and levofloxacin 500mg po qd for 14d. | Drug: Amoxicillin,Levofloxacin<br>* Amoxicillin-Levofloxacin-containing quadruple group<br>|
| Tetracycline-Furazolidone-containing quadruple group<br>Patients in tetracycline-furazolidone-containing quadruple group will receive esomeprazole (Nexium) 40mg po bid(or vonoprazan fumarate 20mg po bid), tetracycline 500 mg po qid, bismuth potassium citrate(Lizhudele) 220mg po bid, and furazolidone (Liteling) 100mg po bid for 14d. | Drug: Tetracycline,Furazolidone<br>* Tetracycline-Furazolidone-containing quadruple group<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The most suitable re-eradication time | The most suitable re-eradication time（The unit is month） will be assessed by paired comparison method . | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Eradication rates in three groups | Both intention to treat(ITT) and per-protocol(PP) analyses will be used for the assessment of the eradication rates of Helicobacter pylori infections in three groups. | 6months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Helicobacter pylori, Re-eradication time, Remedial treatment