Duration of Analgesic Effect for Ultrasound Guided Supraclavicular Blocks With the Addition of Buprenorphine to Local Anesthetic Solution

Study Overview
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Brief Summary
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The patients included will be those who have already agreed to have a brachial plexus nerve block for surgery. A flip of the coin will decide who gets and additive called buprenorphine in their block or not. They will both contain the same amount and type of numbing medicine. The goal will be to see if the additive extends the life of the pain control portion of the ultrasound guided supraclavicular nerve block.

Official Title
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Duration of Analgesic Effect for Ultrasound Guided Supraclavicular Blocks With the Addition of Buprenorphine to Local Anesthetic Solution

Conditions
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Regional Block for Pain Control, Supraclavicular Block, Ultrasound Guided Block, Block Additive

Intervention / Treatment
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* Drug: Buprenorphine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: American Society of Anesthesiologists (ASA) physical status 1-3 Age 18-79, inclusive BMI <36 kg/m^2 Patient consenting to single injection brachial plexus nerve block as primary anesthetic for a procedure Exclusion Criteria: Patients with coagulation disorders Clinically significant pulmonary disease Clinically significant cardiac disease Neurologic deficit in surgical extremity Allergy to bupivacaine or buprenorphine Intolerance of narcotics Local infection over intended area of needle insertion Hepatic failure or renal failure Significant psychiatric disease, including drug abuse Seizure disorder Possible pregnancy or lactation by patient report Use of narcotic medication greater than 2 times a week for greater than 1 week. Patients for whom the surgeon requests a shorter-acting block

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 79 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control group<br>will get only local anesthetic and epinephrine in block. no additive in block | |
| Experimental: buprenorphine<br>will receive local anesthetic, epinephrine and the additive buprenorphine to nerve block | Drug: Buprenorphine<br>* added to nerve block, 0.3mg one time peripheral block use<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time Until First Pain Medication Post-operatively | Time in minutes until first pain medication was take by participant post-operatively | 48 hrs | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain Score on Post Operative Day 1 | pain score on post operative day 1 was measured on a scale 1-10. higher scores correlates with more severe pain. score range is from '0' (no pain) to 10 (pain as severe as it can be) | 1 day postoperative | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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nerve block, outpatient surgery