linjc16/ctgov huggingface dataset:
Exposure to Neurotoxins as Risk Factors for Amyotrophic Lateral Sclerosis

Study Overview
=================
Brief Summary
-----------------
This study is a follow-up to an earlier study that examined the relationship of This study will examine whether exposure to neurotoxins, such as lead, mercury, solvents, and pesticides, can contribute to amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. The cause of this degenerative disease of the brain and spinal cord is not well understood. Some studies suggest that exposure to environmental neurotoxins may increase its risk. This follow-up study will examine the relationship of neurotoxin exposure to the interval between the diagnosis of ALS and death. It will also examine the possible roles of genetics, lifestyle and dietary factors in the disease. Information on ALS patients previously enrolled in the study will be used to examine this relationship. No new individuals will be enrolled in the study.

Detailed Description
-----------------
Objective: The objective of this proposal is linkage with the National Death Index (NDI) for cases from a study that was conducted in the early 1990's. The purpose of the initial study was to examine the role that lead and other exposures, including mercury and solvents, play in the etiology of amyotrophic lateral sclerosis (ALS). Study population: The study involved 110 ALS cases and 256 population based controls, recruited in New England between 1993 and 1996. Data collection involved an interview, blood collection, and measurement of bone lead using x-ray fluorescence. Design and outcome parameters: The results of this study suggested that lead exposure was a risk factor for ALS. Compared to controls, cases were more likely to have occupational lead exposure, and both blood and bone lead levels were higher in cases. We are presently analyzing data on other neurotoxic exposures including mercury, solvents, and pesticides. In order to investigate prognosis, we would like to determine the date of death by searching the National Death Index. This information will enable us to evaluate the relationship of neurotoxic exposures to ALS prognosis.

Official Title
-----------------
Ascertainment of Death in ALS Patients

Conditions
-----------------
Amyotrophic Lateral Sclerosis, ALS

Participation Criteria
=================
Eligibility Criteria
-----------------
INCLUSION CRITERIA: The purpose of the NDI search will be to verify death and obtain date and cause of death information for the study participants.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
ALS, Case-Control Study, Death Certificates, National Death Index, Cause of Death Information, Lead Exposure, Amyotrophic Lateral Sclerosis
Acute Kidney Injury in Adult Patients Supported by VA-ECMO

Study Overview
=================
Brief Summary
-----------------
Post-cardiotomy cardiogenic shock (PCCS) occurs in 2-6% of patients undergoing cardiac surgery, and 1% of cardiac surgery patients will require mechanical circulatory support using Veno-Arterial ExtraCorporeal Membrane Oxygenation (VA-ECMO). Acute Kidney Injury is a frequent complication in this population and negatively impacts the survival. We aimed to determine whether the timing of ECMO implantation influence the renal prognosis of these patients.

Official Title
-----------------
Risk Factors and Prognosis of Acute Kidney Injury in Peri Operative Cardiac Surgery Adult Patients Supported by VA-ECMO

Conditions
-----------------
Acute Kidney Injury, Cardiogenic Shock

Intervention / Treatment
-----------------
* Other: No intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients admitted in post-operative of cardiac surgery Assisted by VA-ECMO Exclusion Criteria: Chronic hemodialysis Death occurring within the first 48 hours of VA-ECMO implantation Multiple VA-ECMO during the same hospitalization.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1<br>Patients admitted in the surgical intensive care unit in post-operative of cardiac surgery between January 2013 and December 2016 + Assisted by VA-ECMO + with KDIGO stage 3 AKI | Other: No intervention<br>* No intervention<br>|
| Group 2<br>Patients admitted in the surgical intensive care unit in post-operative of cardiac surgery between January 2013 and December 2016 + Assisted by VA-ECMO + without KDIGO stage 3 AKI and alive at D10 | Other: No intervention<br>* No intervention<br>|
| Group 3<br>Patients admitted in the surgical intensive care unit in post-operative of cardiac surgery between January 2013 and December 2016 + Assisted by VA-ECMO + died before D10 without KDIGO stage 3 AKI | Other: No intervention<br>* No intervention<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Occurrence of a stage 3 AKI | Number of Participants with Stage 3 Acute Kidney Injury according to the Kidney Disease: Improving Global Outcomes (KDIGO) group | Day 10 after ECMO implantation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality at Day 30 | Number of Deceased Participants | Day 30 after ECMO implantation | 
| Mortality at 6 months | Number of Deceased Participants | 6 months after ECMO implantation | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Acute Kidney Injury, ECMO, Post Cardiogenic Shock Syndrome
Measuring the Impact of a Multimodal Intervention on Falls and Fear Falls Among People 65 Years Old, Residents at Home

Study Overview
=================
Brief Summary
-----------------
Measuring the Impact of a Multimodal Intervention on Falls and Fear Falls among People 65 Years Old, Residents at Home in Boulogne city

Detailed Description
-----------------
We hypothesize that participation in the multimodal program  Autonomy Prevention Kit  would lead to a decrease in falls and the fear of falling. this study targets retired people, 65 years of age and over, living at home, identified as being independent (Iso Group Resources type 4-5-6 without formal validation being carried out) but who represent statistically an increased risk of falls in comparison to the general population. The inclusion takes place before the first session of the Equilibr'Age® workshop. Subjects will have already benefited from a first collective information organized by the Boulogne City Council (see annexes of the CRF). 3 times mark the collection of data. At the time of inclusion, at the end of the 12 sessions of the Equilbr'Age® workshop (M3) and 3 months after the end of the workshop ( 6 months after the beginning of inclusion). The study does not involve new acts since it is only an assessment of the effects of a protocol that proposes non-sports activities as well as advice to citizens of the municipality.

Official Title
-----------------
Measuring the Impact of a Multimodal Intervention on Falls and Fear Falls Among People 65 Years Old, Residents at Home

Conditions
-----------------
Fall, Old Age; Atrophy

Intervention / Treatment
-----------------
* Behavioral: fall prevention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Retired Age ≥ 65 years; GIR ≥ 4 Commitment to participate in all interventions of the autonomy prevention Kit Autonomous in its travels The person expressed no objection to participating in the KitPA study. Exclusion Criteria: In professional activity Age < 65 years; GIR < 4 Person under guardianship or curatorship

Ages Eligible for Study
-----------------
Minimum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: fall prevention|Training in physiotherapy sessions and ergonomic home development|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of the number of falls before/after and the fear of falling before/after according Equilibr'Age® workshop | Equilibr'Age® workshop | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of life quality before/after according EQ-ED scale | Quality of life scale | 6 months |
Efficacy of SLT in Patients With Insufficient IOP Control Under Maximum Tolerated Drug Therapy (Eye Drops)

Study Overview
=================
Brief Summary
-----------------
Examination and follow-up of efficacy and safety of SLT in patients with unsufficient IOP control despite maximum tolerated topical therapy. In addition, it will be examined whether medical treatment can be reduced after the SLT procedure and whether filtering surgery - as the only remaining option - may be postponed.

Detailed Description
-----------------
SLT (Selective Laser Trabeculoplasty) uses the Nd:YAG-Lasers (wavelength 532nm, Q-switched, frequency-doubled). Thanks to the low laser energy used and the short duration of treatment, only pigmented cells of the trabecular meshwork are targeted and selectively treated. Neighboring, non-pigmented cells and tissue are spared collateral and thermic damage, the architecture of the trabecular meshwork remains intact. The SLT procedure uses less than 1% of the energy of the ALT procedure with an extremely low pulsation duration. Several studies confirm the effective IOD reduction of SLT and rate the procedure as an relatively safe and effective therapy for glaucoma. Also repeated use of the SLT procedure is considered as meaningful. Meanwhile the SLT procedure is used as primary and supplementary treatment of glaucoma and study confirmed that the SLT procedure was just as effective as administration of Latanoprost in reducing IOD in newly-diagnosed glaucoma.

Conditions
-----------------
Glaucoma

Intervention / Treatment
-----------------
* Device: selective Laser Trabeculoplasty (SLT)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Patients with primary open angle glaucoma (including normal tension glaucoma) pseudoexfoliation glaucoma pigment dispersion glaucoma Exclusion criteria: previous intraocular surgery closed angle glaucoma pediatric glaucoma inflammatory or uveitic glaucoma unclear view of the trabecular meshwork

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: selective Laser Trabeculoplasty (SLT)|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| IOP lowering effect of SLT in a special patient group |  | 1 day, 1 , 3, 6 , 12 months postoperative | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
glaucoma, SLT, Laser treatment, IOP, glaucoma treated with eye drops but IOP not controlled
Evaluation of Brain MRI and Clinical Characteristics of Adolescents With Bipolar Disorder and Children of Parents With Bipolar Disorder

Study Overview
=================
Brief Summary
-----------------
Genetic transition is important in the etiology of bipolar disorder (BD). So, evaluation of children of BD parents and diagnosed with and BD children whether or not brain has affected zones. These groups were compared to healthy controls and whether or not the mental health of children is influenced will be evaluated by the clinical investigation.

Detailed Description
-----------------
MRI studies in children at risk of BD, our understanding of the neurobiology of BD and abnormalities in the studied regions, regions that predispose to the development of our understanding of PBB will shed light on the etiology of the disorder. In this study, the cranial MRI findings and clinical features in adolescents with bipolar disorder and the same age and sex matched children who have parents with BD and healthy controls were investigated. Since there is few studies that evaluate these three groups, there is a need to increase our knowledge on this issue.

Conditions
-----------------
Bipolar Disorder

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children with BD between the ages of 12-18 Parents with BD who have children between the ages of 12-18 Healthy children whose parents do not have BD Patients who does not have mental or organic disability to answer the questions Graduated from primary school Exclusion Criteria: Patients who have mental or organic disability to answer the questions Patients who have a history of any chronic disease which is likely to affect the central nervous system Patients who have a contraindication for any first application for Magnetic Resonance Imaging (MRI)

Ages Eligible for Study
-----------------
Minimum Age: 12 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patient group<br>Children with BD, (20 children) 12-18 year-old who agreed to participate in the study will be established. | |
| Risk group<br>Twenty healthy children of 12-18 years old who have mothers and/or fathers who previously assessed by an adult psychiatrist and diagnosed as BD according to DSM-IV diagnostic criteria, and who agreed to participate in the study. The age and gender of the groups will be matched. | |
| Healthy control group<br>Twenty participants between the ages of 12-18 who agree to participate in the study and whose family members do not have BD. The age and the gender of the groups will be matched. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Bipolar disorder, Children, Cranial MRI
Study of Sand Versus Wood Chip Surfaces on School Playgrounds to Minimize Injury in School Children

Study Overview
=================
Brief Summary
-----------------
This study will compare children's injury rates (arm fracture, head injury and other injuries) when playing on playground equipment on granite sand versus wood fibre playing surfaces. The hypothesis is that injury rates (arm fracture, head injury and other injuries) among school children are equal on granite sand and wood fibre playground surfaces.

Official Title
-----------------
School Playground Surfacing - A Randomized Prospective Comparison of Injury Rates on Sand Versus Wood Chip Surfaces

Conditions
-----------------
Wounds and Injuries, Closed Head Injury

Intervention / Treatment
-----------------
* Behavioral: school playgrounds


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: School children Ages 5-11 Injured on falls from play equipment during supervised school hours Exclusion Criteria: Children injured outside of supervised school hours

Ages Eligible for Study
-----------------
Minimum Age: 5 Years
Maximum Age: 11 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: school playgrounds|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Upper extremity fracture rates |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fracture rates, upper extremity |  |  | 
| Head injury rates |  |  | 
| All injury rates |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
pediatrics, injury, arm fractures, trauma, playground surfaces, fractures
Is Anxiety Affect the Anesthesia Type Performed In Patients During Caeserean Section ?

Study Overview
=================
Brief Summary
-----------------
In this study, investigators wanted to investigate the effect of preoperative anxiety level on anesthesia preference of patient. Before surgery, patients will fill the forms of Pain catastrophising scale (PCS), Beck depression and Beck anxiety scale. After surgery, these forms will be evaluated according to the choice of anesthesia.

Detailed Description
-----------------
Anxiety is present due to many gait in the preoperative period. In studies that investigated anxiety levels in the preoperative period was found that 60-80% of the patients had significant anxiety. The present study is aimed to investigate the effect of preoperative anxiety level on anesthesia preference of cesarean patients. After approval, patients enrolled in the study is invited to complete the Pain Catastrophizing Scale questionnaire, Beck depression and Beck anxiety scale. After surgery, The effect of anxiety on the choice of anesthesia will be evaluated (general or spinal anesthesia).

Official Title
-----------------
Is Anxiety Affect the Anesthesia Type Performed In Patients During Caeserean Section ?

Conditions
-----------------
Anxiety

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Between 18 and 40 years Planned to undergo ceserean An American Society of Anesthesiologists score of 1 or 2 Exclusion Criteria: Psychiatric diseases Rejected to participation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| General anesthesia<br>The effect of anxiety on the choice of anesthesia will be evaluated. | |
| spinal anesthesia<br>Cesarean patients with spinal anesthesia | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anesthesia preference and anxiety | The spinal and general anesthesia preference according to the anxiety level of cesarean patients | one time in three months |
Functional Neural Connectivity at Rest as a Diagnostic Tool for Intolerance to Heat

Study Overview
=================
Brief Summary
-----------------
Functional neural connectivity at rest of 3 groups (heat tolerant, heat intolerant and healthy subjects) will be assessed using the anatomical and functional MRI scans and compared.

Detailed Description
-----------------
20 healthy subjects that had already underwent Heat Tolerance Test (HTT) at the Heller Institute of Medical Research (Sheba Medical Center) will be recruited and divided into 2 groups: heat tolerant and heat intolerant (according to the HTT results). They will be asked to arrive to one experimental day at the imaging department in Sheba Medical Center and undergo anatomical and functional MRI scans. Third group will consist of 10 existing brain scans (separated from personal details) of healthy males, at the same age range and who had never gone through heat injury. Data will be analysed by fMRI expert in order to compare the functional neural connectivity at rest between the three groups.

Official Title
-----------------
Functional Neural Connectivity at Rest, as a Diagnostic Tool for Intolerance to Heat and Return to Duty After Exertional Heat Stroke

Conditions
-----------------
Functional Neural Connectivity

Intervention / Treatment
-----------------
* Device: MRI scans


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: generally healthy subjects underwent heat injury in the past two months underwent Heat Tolerance Test at the Heller Institute of Medical research Exclusion Criteria: drug or alcohol use history of neurological disorders, mental retardation or head injury history or diagnosis of psychiatric disorders claustrophobia

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 25 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| experimental protocol<br>Functional neural connectivity at rest of 3 groups (heat tolerant, heat intolerant and healthy subjects) will be assessed using the anatomical and functional MRI scans and compared. | Device: MRI scans<br>* 20 subject (10 tolerant and 10 intolerant to heat) will undergo MRI scans (GE healthcare manufacturer) as follows: anatomical scan according to standard protocol functional scan according to the standard protocol of rest-state fMRI. scans of 10 healthy subjects will be taken from existing scans at the imaging department.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| functional neural connectivity | MRI scans will be interpreted by fMRI expert and then compared between heat tolerant and intolerant subjects. | one day |