Mortality in Cancer Patients Admitted to the Intensive Care Unit in a Resource-limited Setting

Study Overview
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Brief Summary
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The purpose of this study is to determine 30 day mortality in cancer patients admitted to the intensive care unit in a resource limited setting.

Detailed Description
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The management of cancer patients in the intensive care unit (ICU) has changed dramatically during the last two decades. Initial experiences showed high rates of hospital mortality, reaching up to 75-85% in patients requiring life-sustaining treatments, particularly mechanical ventilation. An increasing number of clinical experiences has been reported pointing to a significant improvement in survival of these patients. However, it is not clear if this results are generalizable to settings with resource constraints. Therefore, the purpose of this study is to determine 30 day mortality in cancer patients admitted to the intensive care unit in a resource limited setting. This study is a prospective cohort of cancer patients admitted to the ICU in which the investigators will evaluate the prognostic of cancer patients admitted for a ICU trial or treatment in ICU without limitations. This study will not consider any change in the treatment plan of the patients. The source of the data will be the clinical records of the patients during the admission and the records of the cancer unit. There will be no direct contact of the research team with the patients or their family.

Official Title
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Mortality in Cancer Patients Admitted to the Intensive Care Unit in a Resource-limited Setting: A Prospective Cohort Study

Conditions
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Cancer

Intervention / Treatment
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* Other: Cancer patients admitted to the ICU


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 years-old or older Histological diagnosis or high clinical suspicious of cancer (solid /hematological), with the exception of non-melanoma skin cancer. Functional classification state between 0-3, according to Eastern Cooperative Oncology Group. Admission to intensive care unit, because of one or more of the following criteria: Invasive or non-invasive ventilatory support due to acute respiratory failure. Use of vasopressor drugs due to hypotension defined as noradrenaline requirement higher than 0.1 microgram/Kg/min. Renal replacement therapy due to acute renal failure. Exclusion Criteria: Absence of cancer recurrences in more than 5 years after diagnosis Functional classification state of 4, according to Eastern Cooperative Oncology Group.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cancer patients admitted to the ICU<br>Patients with cancer admitted to the ICU. No intervention will be administered. | Other: Cancer patients admitted to the ICU<br>* There will be no change in the standard ICU treatment.<br>* Other names: Standard intensive care unit management.;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality at 30 days |  | 30 days since ICU admission | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality at 180 days |  | 180 days since ICU admission | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cancer, Intensive care unit, Mortality