Early Diagnosis of Alzheimer's Disease: Clinical, Neuropsychological and Neuroimaging Follow-up of a Cohort of Patients With an Isolated Memory Impairment

Study Overview
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Brief Summary
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The aim of this project is to follow cohort of patients with aMCI in order to establish whether there are distinct subgroups in terms of evolution or aetiology, with distinct memory profiles and profiles of mesiotemporal atrophy and metabolic change

Detailed Description
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The syndrome of amnestic Mild Cognitive Impairment (aMCI) has been introduced for patients with intact activities of daily living, with a memory complaint and objective memory decline on neuropathological assessment, without significative change in other domains of cognition. Follow-up in these patients shows that the memory impairment may remain stable or improve, while it worsens or extends to other cognitive domains in others, indicating prodromal AD.

Official Title
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Early Diagnosis of Alzheimer's Disease: Clinical, Neuropsychological and Neuroimaging Follow-up of a Cohort of Patients With an Isolated Memory Impairment

Conditions
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Alzheimer's Disease

Intervention / Treatment
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* Other: Neurological and neuropsychological consultation, MRI
* Other: Neurological and neuropsychological consultation, MRI, Studies in imaging of drip, DNA


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients beforehand include in the PHRC 2001 study (These patients presented to the inclusion in the PHRC 2001 a qualified board of amnestic Mild Cognitive Impairment [aMCI] or light cognitive confusion of type amnestic) The patient must be affiliated to an insurance scheme disease to participate in this study Exclusion Criteria: For the magnetic resonance imaging: usual contraindications for an examination by MRI: claustrophobia, metal foreign bodies, pacemakers, etc. Incapacitated to realize the neuropsychological evaluation because of medical intercurrentes disorders Appointment of a guardian

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: 1<br>Subject control | Other: Neurological and neuropsychological consultation, MRI<br>* Neurological and neuropsychological consultation, MRI for the month 0, 18 and 36<br>|
| Experimental: 2<br>40 patients before hand include in a program | Other: Neurological and neuropsychological consultation, MRI, Studies in imaging of drip, DNA<br>* Neurological and neuropsychological consultation, MRI, Studies in imaging of drip, DNA, months 0/18/36<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pursue the longitudinal study of a troop of subjects presenting an amnestic MCI in 36 months after the initial diagnosis |  | 36 months | 
| Characterize the clinical evolution of these subjects: escalation with appearance of an insanity (of type Alzheimer's disease or of another type: degenerations fronto-temporal, insanity with body of Lewy), stabilization even improvement. |  | 36 months | 
| Identify the neuropsychological markers and of neuroimaging structural and metabolic useful in clinical practice which allow to predict an escalation |  | 36 months | 
| Identify the neuropsychological markers and of neuroimaging structural and metabolic useful in clinical practice which allow to predict a stabilization or an improvement. |  | 36 months | 
| Improve the state of the knowledge on the origin of the confusions mnésiques isolated at the persons of fifty and more years old. |  | 36 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Establish diagnostic criteria which allow to improve the sensibility and the specificity of the premature diagnosis of MY. |  | 36 months | 
| Determine if the ultra-premature diagnosis of MY at a stage where the hurts are still confined in the structures under - hippocampiques is possible. |  | 36 months | 
| Determine the specific character or not of the infringement of the memory of visual recognition in the novice Alzheimer's disease. |  | 36 months | 
| Determine the specific character or not the atrophy and the metabolic modifications of regions under - hippocampiques in the novice Alzheimer's disease. |  | 36 months | 
| Inform the existence of process of functional compensation in the population of aMCI, notably to those who show themselves stable or improve. |  | 36 months |