Surgery for Locally Advanced Colon Cancer: is it Worth it? A Multicenter Retrospective Analysis.

Study Overview
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Brief Summary
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The aim of the present study is to assess the post-operative outcomes (morbidity and mortality) in relation to preoperative data and the oncological outcomes (overall and disease-free survival) in patients with a locally advanced colon cancer (LACC) with the necessity of a multivisceral resection (MVR).

Detailed Description
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All patients that meet the inclusion criteria will be registered in a retrospective database from 2014 to 2019 (5 years) Data will be reported for every patients with colon cancer to have had either a resection of another organ or structure in addition to resection of the primary tumor, or to have had a T4 (a or b) tumour on postoperative histopathology. Data included are patient demographics, ASA score, tumor localization, preoperative imaging, neoadjuvant treatments, type of bowel resection and adjacent organs resected, tecnique (laparoscopic/laparotomic), postoperative complications and 30-day mortality, histopathology data including TNM scoring, completeness of surgical procedure (R0 to R2) and infiltration of tumor cells in resected tissues, adjuvant oncological treatments, and long term follow-up data on local and distant recurrence and survival.

Official Title
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Surgery for Locally Advanced Colon Cancer: is it Worth it? A Multicenter Retrospective Analysis. (LACC Trial)

Conditions
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Malignant Neoplasm of Large Intestine TNM Staging Primary Tumor (T) T4

Intervention / Treatment
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* Procedure: Multivisceral resection


Participation Criteria
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Eligibility Criteria
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Inclusion criteria > 18 aa Patients with a locally advanced colon cancer (LACC) with the necessity of a multivisceral resection (MVR). Exclusion criteria Stage IV Rectal cancer Emergency surgery (<48 hours from admission) ASA > III

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Multivisceral resection|Multivisceral resection for locally advanced colon cancer.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative morbidity | I evaluate peri and post-operative surgical (e.g. intraabdominal collection, fistula, anastomotic leak) and medical (e.g. pneumoniae, deep vein thrombosis) complications | 30 days | 
| Postoperative mortality | I evaluate in-hospital and 30-day mortality correlate to the intervention | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall Survival | The length of time from the intervention that patients diagnosed with a T4 colon cancer are still alive. | 5 years | 
| Disease Free Survival | The measure of time after treatment during which no sign of recurrence (local or metastatic) is found. | 5 years |