Gastrointestinal Motor Disorders (Esophageal and Anorectal) After COVID-19

Study Overview
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Brief Summary
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The patients who had COVID-19 infection, and after that reported for one of the signs of gastrointestinal disorder (esophageal and anorectal) will be underwent to esophageal and anorectal motor monitoring investigation (HRM manometry) on standard protocol.

Detailed Description
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The patients who had COVID-19 infection, and after that reported for one of the signs of gastrointestinal (esophageal and anorectal disorder) will be underwent to esophageal and anorectal motor monitoring investigation (HRM manometry) on standard protocol. The patients with dysphagia, chest discomfort during swallowing, or chest pain during swallowing, patients with obstipation, fecal evacuation symptoms, lower stomach discomfort before defecation etc. will be included in the study. In all of them other gastrointestinal diseases will be excluded by standard routine laboratory investigation, ultrasound, routine endoscopy investigation and 24 hours impedance pH-measurement. After manometric measurement of esophagus and anorectal region to standard protocol by using MMS-HRM 360 monitoring system with 36 canals catheter for esophagus and 24 canals catheter for anorectal monitoring, data will be calculated by using statistics.

Official Title
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Gastrointestinal Motor Disorders (Esophageal and Anorectal) in Patients After COVID-19 Infection

Conditions
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Gastrointestinal Motility Disorder

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with esophageal and anorectal symptoms after COVID 19- infection Patients with worsening of esophageal and anorectal symptom after COVID 19- infection, but who had previously described esophageal and anorectal symptoms Exclusion Criteria: Other gastrointestinal disease that can influence to results Gastroesophageal reflux H. Pylori infection Bacterial, parasitic, viral and fungal gastrointestinal infection or infestation Myasthenia Scleroderma Diabetes mellitus Thyroidal hyperfunction

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| esophageal manometry<br>The patients who has previously mentioned symptoms will underwent to manometry monitoring of esophageal and anorectal disorders. For this investigation we have proven normal and standardized manometric values on previous investigations by other authors, so the control group is not needed. We know the normal manometric values (Chicago 3 score). | |
| anorectal manometry<br>The patients who has previously mentioned symptoms will underwent to manometry monitoring of esophageal and anorectal disorders. For this investigation we have proven normal and standardized manometric values on previous investigations by other authors, so the control group is not needed. We know the normal manometric values (London protocol). | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of esophageal parameters 1 on manometry | In esophagus we will measure Upper and lower esophageal sphincter pressure in mmHg. | 120 days | 
| Measurement of esophageal parameters 2 on manometry | In esophagus we will measure Integrated relaxation pressure (IRP) in mmHg. | 120 days | 
| Measurement of esophageal parameters 3 on manometry | In esophagus we will measure Contractile front velocity (CVF) in cm/s. | 120 days | 
| Measurement of esophageal parameters 4 on manometry | In esophagus we will measure Distal contractile integral (DCI) in mmHg.s.cm. | 120 days | 
| Measurement of esophageal parameters 5 on manometry | In esophagus we will measure Distal latency (DL) in seconds. | 120 days | 
| Measurement of esophageal parameters 6 on manometry | In esophagus we will measure Peristaltic brake (BR) in cm. | 120 days | 
| Measurement of anorectal parameters 1 on manometry | On anorectal manometry we will measure Resting test pressure in mmHg. | 2 years | 
| Measurement of anorectal parameters 2 on manometry | On anorectal manometry we will measure Squeeze test pressure in mmHg. | 2 years | 
| Measurement of anorectal parameters 3 on manometry | On anorectal manometry we will measure Endurance squeeze test pressure in mmHg. | 2 years | 
| Measurement of anorectal parameters 4 on manometry | On anorectal manometry we will measure recto-anal inhibitory reflex test (RAIR)- relaxation in percent. | 2 years | 
| Measurement of anorectal parameters 5 on manometry | On anorectal manometry we will measure Push test pressure in mmHg. | 2 years | 
| Measurement of anorectal parameters 6 on manometry | On anorectal manometry we will measure Sensation test with ml in balloon. | 2 years | 
| Measurement of anorectal parameters 7 on manometry | On anorectal manometry we will measure Balloon expulsion test as positive or negative. | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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After COVID-19, gastrointestinal motility