Risk Factors of Spontaneous Fungal Peritonitis in Cirrhotic Patients

Study Overview
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Brief Summary
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Spontaneous bacterial peritonitis (SBP) is an infection of the peritoneal cavity with no surgically treatable intra-abdominal source of infection. Spontaneous peritonitis is a potentially fatal complication in patients with advanced liver cirrhosis. It is estimated that 10-20 % of patients with cirrhotic ascites may develop spontaneous peritonitis, which is usually caused by a bacterial infection. In contrast, spontaneous fungal peritonitis (SFP) is less well-recognized. SFP may be associated with higher mortality rates than SBP but therapeutic approaches are largely undefined. To this end, the epidemiology and outcomes of patients with SFP have only been documented sporadically aimed to evaluate the risk factors for the development of spontaneous fungal peritonitis (SFP), and the prognosis of SFP compared with SBP

Detailed Description
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Cross-sectional study Studied population & locality: Patients with signs and symptoms suggestive of spontaneous peritonitis who will be admitted to Tropical medicine and Gastroenterology or Internal medicine departments in Sohag university hospitals during the period from september 2021 to december 2022 will be included in the study. According to the results of ascitic fluid analysis, we will divide the patients into 2 groups: Group (1): patients with spontaneous bacterial peritonitis (SBP). Group (2): patients with spontaneous fungal peritonitis (SFP). Exclusion criteria: Patients seropositive for human immunodeficiency virus (HIV) and patients undergoing continuous ambulatory peritoneal dialysis were excluded from this study. Methods: All included patients will be subjected to: Detailed history, complete general and systemic examination. Ascitic fluid analysis Bacterial and fungal culture from ascitic fluid: Laboratory investigations: Fasting blood sugar Liver function tests. CBC. Ethical considerations:

Official Title
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Risk Factors of Spontaneous Fungal Peritonitis in Cirrhotic Patients

Conditions
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Spontanous Fungal Peritonitis

Intervention / Treatment
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* Diagnostic Test: ASCITIC FLUID CULTURE


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with signs and symptoms suggestive of spontaneous peritonitis who will be admitted to Tropical medicine and Gastroenterology or Internal medicine departments in Sohag university hospitals during the period from September 2021 to december 2022 Exclusion Criteria: Patients seropositive for human immunodeficiency virus (HIV) and patients undergoing continuous ambulatory peritoneal dialysis were excluded from this study.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| spontaneous bacterial peritonitis<br>cirrhotic patients diagnosed with SBP | Diagnostic Test: ASCITIC FLUID CULTURE<br>* Ten milliliters of ascitic fluid will be collected at the bedside and inoculated into aerobic and anaerobic blood culture bottles. Bacterial culture will be performed manually using MacConkey and blood agar plate<br>|
| spontaneous fungal peritonitis<br>irrhotic patients diagnosed with SFP | Diagnostic Test: ASCITIC FLUID CULTURE<br>* Ten milliliters of ascitic fluid will be collected at the bedside and inoculated into aerobic and anaerobic blood culture bottles. Bacterial culture will be performed manually using MacConkey and blood agar plate<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| he risk factors for the development of spontaneous fungal peritonitis | number/percentage | September 2021 to December 2022 will be included in the study. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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spontanous fungal peritonitis, liver cirrhosis, risk factors