Combination Chemotherapy With or Without Surgery and Radiation Therapy in Treating Patients With Mesothelioma That Can Be Removed By Surgery

Study Overview
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Brief Summary
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RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving combination chemotherapy before surgery may shrink the tumor so that it can be removed. Giving radiation therapy after surgery may kill any tumor cells that remain after surgery. It is not yet known whether combination chemotherapy is more effective with or without surgery and radiation therapy in treating mesothelioma. PURPOSE: This randomized clinical trial is studying combination chemotherapy, surgery, and radiation therapy to see how well they work compared to combination chemotherapy alone in treating patients with mesothelioma that can be removed by surgery.

Detailed Description
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OBJECTIVES: Compare the feasibility of neoadjuvant combination chemotherapy with vs without surgery and adjuvant radiotherapy in patients with resectable malignant mesothelioma. Compare the overall survival of patients treated with these regimens. Compare the quality of life of patients treated with these regimens. OUTLINE: This is a multicenter, pilot study followed by a randomized, controlled study. Patients undergo 3 courses of a platinum-based (cisplatin or carboplatin) combination chemotherapy regimen to be determined by the treatment center. Upon completion of combination chemotherapy, patients are randomized to 1 of 2 treatment arms provided tumor is resectable and there is no disease progression. Arm I: Patients undergo extra-pleural pneumonectomy followed by post-operative radiotherapy. Arm II: Patients undergo follow-up only. Patients may receive additional standard therapy according to their treatment center. Quality of life is assessed at baseline, every 3 months for 1 year, every 6 months for 1 year, and then annually thereafter. After completion of study treatment, patients are followed periodically for 2 years and then annually thereafter. Peer Reviewed and Funded or Endorsed by Cancer Research UK PROJECTED ACCRUAL: A total of 50-670 patients will be accrued for this study.

Official Title
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Mesothelioma and Radical Surgery Trial

Conditions
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Malignant Mesothelioma

Intervention / Treatment
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* Drug: chemotherapy
* Procedure: adjuvant therapy
* Procedure: conventional surgery
* Procedure: neoadjuvant therapy
* Radiation: radiation therapy


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Histologically and immuno-histochemically confirmed malignant mesothelioma Resectable disease (T1-3, N0-1, M0) with no distant metastases Eligible to undergo extra-pleural pneumonectomy based on British Thoracic Society guidelines PATIENT CHARACTERISTICS: Performance status WHO 0-1 Life expectancy Not specified Hematopoietic Not specified Hepatic Not specified Renal Normal renal function Cardiovascular Ejection fraction ≥ 40% Pulmonary Predicted post-operative FEV_1 ≥ 40% Predicted post-operative DLCO ≥ 40% No significant pulmonary hypertension Other No physical or personal condition that would preclude ability to undergo chemotherapy or post-operative radiotherapy No physical or personal condition that would preclude ability to comply with follow-up requirements PRIOR CONCURRENT THERAPY: Not specified

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: chemotherapy|nan|
|Procedure: adjuvant therapy|nan|
|Procedure: conventional surgery|nan|
|Procedure: neoadjuvant therapy|nan|
|Radiation: radiation therapy|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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localized malignant mesothelioma