Biological Determinants of Sputum Rheology in Chronic Airway Diseases

Study Overview
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Brief Summary
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The primary objective of this study is to investigate the biological determinants of sputum rheology variations.

Detailed Description
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Secondarily, this study aims to compare rheology parameters between different chronic airway disease sub-populations.

Official Title
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Biological Determinants of Sputum Rheology in Chronic Airway Diseases

Conditions
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Asthma, COPD, Bronchiectasis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Affiliate with or beneficiary of the French national single-payer health insurance system Patient capable of spontaneous mucus expectoration Consulting or hospitalized at the study centre Inclusion Criteria for the Asthma Group Never- or former-smoker (<10 pack-years) Medical history compatible with asthma Reversible post-brochodilator (or post-corticosteroid test) ventilatory obstruction (ratio of forced expiratory volume in 1 second : forced vital capacity < 70%) or significant variation in respiratory function -- OR -- Bronchial hyperresponsiveness demonstrated during a broncho-provocation test Inclusion Criteria for the COPD Group Current- or former-smokers (>10 pack years) Chronic obstructive pulmonary disease according to GOLD criteria Inclusion Criteria for the Bronchiectasis Group Presence of bronchiectasis on computed tomography scan Cystic fibrosis has been ruled out Exclusion Criteria: Patient expresses opposition to the protocol Breast feeding or pregnant Metastatic neoplastic disease Other active pulmonary disease (tuberculosis, interstitial lung disease) Recent psychiatric disorder (in the past year and documented via a specialist consult) Consumption of illicit drugs or alcoholism Patients in an exclusion period determined by another study Patients under any type of legal guardianship Prisoners Impossible to correctly inform the patient Does not fluently read French Emergency situations

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Asthma<br>The patients included in this group will have asthma, as specified in the inclusion criteria. | |
| COPD<br>The patients included in this group will have COPD, as specified in the inclusion criteria. | |
| Bronchiectasis<br>The patients included in this group will have bronchiectasis, as specified in the inclusion criteria. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of crossover stress (mucus rheology) | The crossover stress point for each mucus sample will be measured in Pa. | Day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of the storage modulus (mucus rheology) | The storage modulus point for each mucus sample will be measured in Pa. | Day 0 | 
| Measurement of the loss modulus (mucus rheology) | The loss modulus point for each mucus sample will be measured in Pa. | Day 0 | 
| Measurement of the strain crossover (mucus rheology) | The strain crossover point for each mucus sample will be measured in Pa. | Day 0 | 
| Measurement of the loss factor (mucus rheology) | The loss factor point for each mucus sample will be measured as a tangent to an angle in radians. | Day 0 |