Epidemiology of Carbapenemase-producing Bacteria in a Swiss Tertiary Care Hospital

Study Overview
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Brief Summary
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This retrospective and prospective study is to investigate the incidence of Carbapenemase-producing bacteria (CPB) at the University Hospital Basel, the time to detection of CPB and to initiation of infection control measures, the risk factors associated with carriage of CPB, type and duration of previously administrated antibiotic medication, antibiotic treatment, as well as to assess the outcomes of the affected patients.

Official Title
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Epidemiology of Carbapenemase-producing Bacteria in a Swiss Tertiary Care Hospital

Conditions
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Infections With CPB

Intervention / Treatment
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* Other: data collection for demographic data
* Other: data collection for clinical data
* Other: data collection for treatment data
* Other: data collection for microbiological data


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with detection of carbapenemase-producing bacteria from January 1st , 2008 until December 31st , 2028 Exclusion Criteria: Patients with documented refusal of subsequent use of their data

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: data collection for demographic data|data collection for demographic data (age, gender, hospital admission and discharge date, length of stay, hospitalization prior to current hospital stay (acute care facilities, long-term healthcare centres, nursing homes), discharge destination, outcome, cause of death, travel history, previous exposure to antibiotics and proton pump Inhibitors)|
|Other: data collection for clinical data|data collection for clinical data (comorbidities, Charlson Comorbidity Index, immunosuppressive treatment, date of diagnosis of CPB, days between hospital admission and diagnosis of CPB, type of consecutive infection, indwelling vascular hardware, urinary catheterization, surgical therapies)|
|Other: data collection for treatment data|data collection for treatment data (antibiotic therapy, immunosuppressive therapy, concomitant medication)|
|Other: data collection for microbiological data|data collection for microbiological data (species of CPB, type of sample, date of sample, history of colonization or infection with any antibiotic resistant pathogen)|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| incidence of CPB at the University Hospital Basel (number) | incidence of CPB at the University Hospital Basel (number) | from January 1st , 2008 until December 31st, 2028 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| time to detection of CPB (days) | time to detection of CPB (days) | from January 1st , 2008 until December 31st, 2028 | 
| time to initiation of infection control measures | time to initiation of infection control measures | from January 1st , 2008 until December 31st, 2028 | 
| time to adequate treatment in patients with CPB infections | time to adequate treatment in patients with CPB infections | from January 1st , 2008 until December 31st, 2028 | 
| presence of established risk factors for CPB | presence of established risk factors for CPB | from January 1st , 2008 until December 31st, 2028 | 
| length of hospital stay (days) | length of hospital stay (days) | from January 1st , 2008 until December 31st, 2028 | 
| discharge destination | discharge destination | from January 1st , 2008 until December 31st, 2028 | 
| cure from infection | cure from infection | from January 1st , 2008 until December 31st, 2028 | 
| cause-specific mortality (number) | cause-specific mortality (number) | from January 1st , 2008 until December 31st, 2028 | 
| all-cause mortality (number) | all-cause mortality (number) | from January 1st , 2008 until December 31st, 2028 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Carbapenemase-producing Klebsiella pneumoniae, antibiotic resistancy, infections with Carbapenemase-producing Bacteria (CPB), Carbapenemase-producing Bacteria