The Efficacy of Isocapnic Hyperpnoea to Accelerate Recovery After General Anesthesia With Sevoflurane

Study Overview
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Brief Summary
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The twilight phase between being asleep and awake during recovery from anesthesia is a precarious time fraught with risks to the post-operative patient. Hyperventilation accelerates the elimination of inhaled anesthetics but reduces their CO2 blood concentrations which delays their resumption of spontaneous breathing. We previously showed that our method of hyperventilation without affecting the CO2 concentration--which we call IH--accelerates the rate of emergence from anesthesia with isoflurane. In this study we will study the effect of IH on the rate of emergence from Sevoflurane anesthesia.

Official Title
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The Efficacy of Isocapnic Hyperpnoea to Accelerate Recovery After General Anesthesia With Sevoflurane.

Conditions
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Anesthesia

Intervention / Treatment
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* Procedure: Isocapnic Hyperponea


Participation Criteria
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Eligibility Criteria
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Inclusion criteria: Elective gynecological procedure ASA I-III Age 18-80 years Signed informed consent Exclusion criteria: ASA IV Patients with contra-indications to Sevoflurane anesthesia or other anesthetics included in the protocol Active smoking, asthma or other history of hyper-reactive airway disease History of chronic obstructive lung disease limiting exercise History of angina, previous myocardial infarction, valvular heart disease, or heart surgery Presence of heart murmurs or neck bruits ECT abnormalities including atrial fibrillation, prolonged P-R interval, prolonged Q-T interval, presence of Q waves in inferior, anterior or lateral leads, criteria for left ventricular hypertrophy, T-wave abnormalities, History of difficult airway access Pulmonary hypertension and/or right ventricle dysfunction History of bulous emphysema, and/or spontaneous pneumothorax History of alcohol or drugs abuse Known history of psychiatric illness and/or medications Patients that required postoperative mechanical ventilation for any reason

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Isocapnic Hyperponea|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to recovery from anesthesia as indicated by time to extubation and rate of change of BIS score |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of recovery in the recovery room as indicated by the level of consciousness, incidence of nausea, vomiting, shivering and other phenomena occuring during recovery |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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general anesthesia, hyperventilation, carbon dioxide, isocapnic hyperponea