Peripheral Stem Cell Transplantation Followed By Infusion of White Blood Cells in Treating Patients With AIDS-Related Lymphoma

Study Overview
=================
Brief Summary
-----------------
RATIONALE: Donor peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy. Sometimes the transplanted cells are rejected by the body's normal tissues. Treatment with donor white blood cells may prevent this from happening. PURPOSE: Phase II trial to study the effectiveness of donor peripheral stem cell transplantation followed by infusions of donor white blood cells in treating patients who have AIDS-related lymphoma.

Detailed Description
-----------------
OBJECTIVES: Determine the response rate of patients with AIDS-related lymphoma treated with allogeneic peripheral blood stem cell (PBSC) transplantation followed by delayed donor leukocyte infusion. Determine the complication rate of these patients treated with PBSC transplantation. Determine the immune dysfunction and recovery of patients treated with this regimen. OUTLINE: This is a multicenter study. Patients receive cyclophosphamide IV over 60 minutes on days -5 to -3. Patients who have not received prior mediastinal radiotherapy receive thymic radiotherapy on day -1. Allogeneic peripheral blood stem cells are infused on day 0. Patients also receive anti-thymocyte globulin IV over 10-12 hours on days -1, 1, 3, and 5 and cyclosporine IV beginning on day -1, switching to oral when possible, and tapering until day 35. In the absence of active acute graft-versus-host disease (GVHD), and at least 2 weeks after completion of cyclosporine, patients receive an infusion of donor leukocytes on or before day 49. Patients may receive a second donor leukocyte infusion if there is evidence of persistent malignancy and no GVHD. Patients are followed through day 100, on days 120, 180, 270, and 365, and then every 6 months thereafter. PROJECTED ACCRUAL: A total of 12-35 patients will be accrued for this study within 3-4 years.

Official Title
-----------------
Delayed Donor Leukocyte Infusions in Patients Receiving Allogeneic PBSC Following Conditioning With Non-myeloablative Regimen for AIDS-Related Lymphoma (NHL and HD)

Conditions
-----------------
Lymphoma

Intervention / Treatment
-----------------
* Biological: anti-thymocyte globulin
* Biological: therapeutic allogeneic lymphocytes
* Drug: cyclophosphamide
* Drug: cyclosporine
* Procedure: peripheral blood stem cell transplantation
* Radiation: radiation therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
DISEASE CHARACTERISTICS: Diagnosis of Hodgkin's disease or non-Hodgkin's lymphoma Failed to achieve a complete remission with initial therapy OR Relapsed after initial therapy HIV-1 seropositive by Western Blot Measurable or evaluable (e.g., pleural fluid involvement) disease No leptomeningeal or parenchymal CNS involvement or active CNS leukemia HLA-A, B, or DR antigen matched or 1 antigen mismatched related donor available CD4 cell count greater than 100/mm3 (initial 12 patients) OR greater than 50/mm3 (subsequent patients)* HIV RNA less than 110,000 copies/mL* NOTE: *Unless not receiving optimal anti-retroviral therapy as defined by current clinical standards PATIENT CHARACTERISTICS: Age: Physiologic 65 and under Performance status: Karnofsky 70-100% Life expectancy: Estimated disease-free survival less than 1 year Hematopoietic: See Disease Characteristics Hepatic: Bilirubin no greater than 2 mg/dL Alkaline phosphatase no greater than 3 times upper limit of normal (ULN)* SGOT or SGPT no greater than 3 times ULN* Hepatitis B surface antigen negative NOTE: *Unless receiving indinavir Renal: Creatinine no greater than 1.5 mg/dL Creatinine clearance at least 50 mL/min Cardiovascular: No symptomatic congestive heart failure No angina pectoris No uncontrolled hypertension LVEF at least 45% by radionuclide ventriculography Pulmonary: No severe chronic obstructive lung disease No symptomatic restrictive lung disease DLCO greater than 50% predicted Other: No active uncontrolled infection No history of cytomegalovirus retinitis or pneumonitis, even if treated No other disease that would limit life expectancy No symptomatic leukoencephalopathy No neuropsychiatric abnormalities that would preclude transplantation Human T-cell lymphotrophic virus (HTLV-1) antibody negative Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception during and for 3 months after study PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: At least 1 week since prior chemotherapy Endocrine therapy: Not specified Radiotherapy: Not specified Surgery: Not specified Other: No concurrent chronic suppressive therapy

Ages Eligible for Study
-----------------
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: anti-thymocyte globulin|nan|
|Biological: therapeutic allogeneic lymphocytes|nan|
|Drug: cyclophosphamide|nan|
|Drug: cyclosporine|nan|
|Procedure: peripheral blood stem cell transplantation|nan|
|Radiation: radiation therapy|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
AIDS-related peripheral/systemic lymphoma, HIV-associated Hodgkin lymphoma