Cognitive Rehabilitation With C8 Sciences

Study Overview
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Brief Summary
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C8 sciences program is a cognitive training program mainly developed for the students, and the effectiveness is well established. The aim of this trial is to assess clinical efficacy of the program for cognitive rehabilitation of the patients with stroke or brain injury.

Official Title
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Cognitive Rehabilitation for Participants With Stroke or Brain Injury Using C8 Sciences

Conditions
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Stroke, Brain Injuries

Intervention / Treatment
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* Other: Computerized cognitive training program
* Other: Conventional cognitive rehabilitation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participants with stroke or brain injury Cognitive deficits Exclusion Criteria: Uncontrolled medical comorbidities Not able to perform outcome measurements Aphasia, which hamper communication Pre-diagnosed psychological or other neurological disease not relevant to stroke or brain injury

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: C8 sciences<br>cognitive rehabilitation with C8 sciences | Other: Computerized cognitive training program<br>* 1000 minutes of computerized cognitive rehabilitation with C8 sciences program<br>|
| Active Comparator: Conventional cognitive rehabilitation<br>cognitive rehabilitation with conventional methods | Other: Conventional cognitive rehabilitation<br>* Same amount of conventional cognitive rehabilitation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline Cambridge Neuropsychological Test Automated Battery(CANTAB) Spatial working memory at 34 th intervention |  | Baseline, 34th day from baseline | 
| Change from baseline CANTAB Rapid Visual information Processing at 34 th intervention |  | Baseline, 34th day from baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CANTAB Spatial working memory |  | Baseline, 34th day from baseline, 64th day from baseline | 
| CANTAB Rapid Visual information Processing |  | Baseline, 34th day from baseline, 64th day from baseline | 
| CANTAB Motor control task |  | Baseline, 34th day from baseline, 64th day from baseline | 
| CANTAB Paired Associated Learning |  | Baseline, 34th day from baseline, 64th day from baseline | 
| CANTAB reaction time |  | Baseline, 34th day from baseline, 64th day from baseline | 
| CANTAB Attention Switching Task |  | Baseline, 34th day from baseline, 64th day from baseline | 
| CANTAB Stoking of Cambridge |  | Baseline, 34th day from baseline, 64th day from baseline | 
| CANTAB Emotion Recognition Task |  | Baseline, 34th day from baseline, 64th day from baseline | 
| CANTAB Stop Signal Task |  | Baseline, 34th day from baseline, 64th day from baseline | 
| Geriatric depression scale | Older participants | Baseline, 34th day from baseline | 
| Beck depression index |  | Baseline, 34th day from baseline | 
| Korean Mini-Mental State Examination (K-MMSE) |  | Baseline, 34th day from baseline | 
| Korean activities of daily living (K-ADL) |  | Baseline, 34th day from baseline, 64th day from baseline | 
| Korean instrumental activities of daily living (K-IADL) |  | Baseline, 34th day from baseline, 64th day from baseline | 
| clinical dementia rating scale (CDR) |  | Baseline, 34th day from baseline | 
| Stroke impact scale |  | Baseline, 34th day from baseline | 
| Subjective memory complaint questionnaire |  | Baseline, 34th day from baseline, 64th day from baseline | 
| NIH toolbox |  | Baseline, 17th day from baseline, 34th day from baseline, 64th day from baseline | 
| Autobiographical memory |  | Baseline, 34th day from baseline | 
| Trail making test (A/B) |  | Baseline, 34th day from baseline, 64th day from baseline | 
| Trail making test - Black and White |  | Baseline, 34th day from baseline, 64th day from baseline |