Improving Management of Post-partum Haemorrhage With Quantra® System

Study Overview
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Brief Summary
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Post partum haemorrhage is a concerning situation in maternity wards, though it is not the first cause of maternal mortality anymore. It has been already shown that low fibrinogen level is a major predictive factor of massive bleeding after delivery. In this situation, the early knowledge of fibrinogen level could enhance care of women experiencing post partum haemorrhage. In a cohort of women suffering from post partum haemorrhage, this study will evaluate whether assessing fibrinogen level would be faster using the Quantra® system than the standard coagulation test.

Official Title
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Use of Quantra® System in Clinical Practice to Improve Management of Post-partum Haemorrhage : a Prospective Study

Conditions
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Post Partum Haemorrhage

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Women ≥ 18 years old Experiencing post partum haemorrhage ≥ 500 mL Within 24 hours after delivery Exclusion Criteria: Previous anemia ≤ 7g/dL Known bleeding disorders Ongoing antiplatelets treatment Ongoing anticoagulant treatment

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of delay in obtaining Quantra Fibrinogen Clot Stiffness result to standard fibrinogen level result | Comparison of delay in obtaining Quantra Fibrinogen Clot Stiffness result to standard fibrinogen level result | When post partum haemorrhage occurred, within 24 hours after delivery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of level of fibrinogen assessed by Quantra Fibrinogen Clot Stiffness to level of fibrinogen assessed by standard coagulation test | Fibrinogen level assessed by Quantra and standard coagulation tests | When post partum haemorrhage occurred, within 24 hours after delivery | 
| Comparison of Quantra Clot Time result to Standard Kaolin Clotting time result | Coagulation function assessed by Quantra and standard coagulation tests | When post partum haemorrhage occurred, within 24 hours after delivery | 
| Comparison of Platelet Clot Stiffness result to standard platelet count result | Platelet function assessed by Quantra and standard platelet count. | When post partum haemorrhage occurred, within 24 hours after delivery | 
| Rate of satisfaction of anesthetist in charge of patient assessed by Lickert scale | Rate of satisfaction of anesthetist in charge of patient assessed by Lickert scale [1-Strongly disagree ; 2-Disagree ; 3-Neither agree nor disagree ; 4-Agree ; 5-Strongly agree | When post partum haemorrhage occurred, within 24 hours after delivery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Post partum haemorrhage, Bleeding, Labour, Vaginal delivery, Caesarean section