Silver Bullet (drug)

Haibara remembering Elena's tapes. The tape for her 18th birthday revealed the existence of "Silver Bullet". Tape's contents were revealed between two flashbacks.
"**Silver Bullet**" is the name given to a mysterious drug created by [Elena Miyano](/wiki/Elena_Miyano "Elena Miyano") and [Atsushi Miyano](/wiki/Atsushi_Miyano "Atsushi Miyano"). It is related to the [APTX 4869](/wiki/APTX_4869 "APTX 4869") created by the [Black Organization](/wiki/Black_Organization "Black Organization").
## Contents
* [1 Background](#Background)
* [2 Quotes](#Quotes)
* [3 Speculation](#Speculation)
+ [3.1 "Silver Bullet" and "APTX 4869" are two names for the same project](#.22Silver_Bullet.22_and_.22APTX_4869.22_are_two_names_for_the_same_project)
* [4 See also](#See_also)
* [5 References](#References)
## Background[[edit](/wiki/index.php?title=Silver_Bullet_(drug)&action=edit&section=1 "Edit section: Background")]
19 years ago, the Miyanos were running the Miyano Clinic and not doing research but were considering accepting the [Karasuma Group](/wiki/Karasuma_Group "Karasuma Group")'s offer to sponsor their research.[](#cite_note-1) 17 years ago, revealed through cassette tapes Elena left behind for Shiho[](#cite_note-2), they were working on a certain drug. While their lab mates were excited about it and considered it "a dream drug", Elena considered it "a truly terrifying drug" and the Miyanos were "calling it the *Silver Bullet* in hope" (perhaps in hope that it ends up as a drug for good rather than bad).[](#cite_note-3)[](#cite_note-821p7-4) Elena and Atsushi had to leave behind [Shiho](/wiki/Shiho_Miyano "Shiho Miyano") and [Akemi](/wiki/Akemi_Miyano "Akemi Miyano") in order to complete the drug.[](#cite_note-821p7-4)
After thinking about this message left by Elena, [Ai Haibara](/wiki/Ai_Haibara "Ai Haibara") regrets making [APTX 4869](/wiki/APTX_4869 "APTX 4869") and thinks it is something that should have never been made.[](#cite_note-821p7-4)
The research related to Silver Bullet was partially or wholly destroyed by the fire which also took the Miyanos' lives.[](#cite_note-5) If some of it survived, it is possible that Shiho Miyano incorporated it into one of her modern projects. At the current time, it is still unstated how [Silver Bullet](/wiki/Silver_Bullet "Silver Bullet"), APTX 4869, and any other research projects of the Black Organization are related to one another.
## Quotes[[edit](/wiki/index.php?title=Silver_Bullet_(drug)&action=edit&section=2 "Edit section: Quotes")]
|  |  |  |
| --- | --- | --- |
| “ | Shiho, won't you regret what you are about to do? If so, I'm totally on your side! Well, it will be you nineteenth birthday next time. Bye-bye, honey. Oh yes, maybe it's about time I told you... The truth is, your mom is making a truly *terrifying* drug at the moment. My lab mates are getting really excited about it, they say it's like a dream drug. Your dad and I are calling it the Silver Bullet, putting our wishes in the name. But in order to complete the drug, your dad and I will have to leave you and your sister. Please understand, Shiho. | „ |
| — Part of Elena's message on Shiho's 18th tape.[](#cite_note-6) | | |
## Speculation[[edit](/wiki/index.php?title=Silver_Bullet_(drug)&action=edit&section=3 "Edit section: Speculation")]
### "Silver Bullet" and "APTX 4869" are two names for the same project[[edit](/wiki/index.php?title=Silver_Bullet_(drug)&action=edit&section=4 "Edit section: \"Silver Bullet\" and \"APTX 4869\" are two names for the same project")]
:   *See also: [APTX 4869](/wiki/APTX_4869 "APTX 4869")*
From the loving nature of the Miyanos, it is likely they had good intentions and were trying to create a benevolent drug. From what [APTX 4869](/wiki/APTX_4869 "APTX 4869") became, it could be an anti-aging, de-aging or immortality drug. Elena's 18th tape suggests the drug development showed promise but they also realized the drug's potential to become something bad. APTX 4869 would therefore be a continuation of Silver Bullet in the bad direction. Shiho Miyano also hinted at two different possibilities for the drug when she said that she did not intend to create a poison,[](#cite_note-179p9-7) and "what [the organization] wanted me to make, was another drug".
Haibara took over her parents' research after they died by reconstructing their work from surviving fragments of a lab fire which killed her parents.[](#cite_note-8) One of these projects was the APTX 4869 project. The proof that some version of APTX 4869 existed in the Miyano parents' time lies in a [victims list](/wiki/List_of_Black_Organization_related_characters#APTX_4869_Victims "List of Black Organization related characters") which includes the name of [a man](/wiki/Kohji_Haneda "Kohji Haneda") killed with the drug [17 years prior](/wiki/Case_from_17_years_ago "Case from 17 years ago") to the current timeline. Because Shiho had to reconstruct her parents' research from the fragments that survived, intentionally or unintentionally, it is possible that some of what the Miyanos called the Silver Bullet became incorporated into Shiho's modern version of APTX 4869.
Regardless of what the parents' version of APTX 4869 was intended for, those who know about the shrinking side effect of Shiho's modern version of APTX 4869 have a tendency to compare it to the Miyanos' research. After watching Haibara shrink, Pisco, who knew about the project the Miyanos worked on, commented that Shiho's parents would be proud of the progress Shiho had made on the drug.[](#cite_note-V24-11p9-9) As Haibara was holding and considering taking the antidote to APTX 4869, she thinks back to the tapes. She then regrets having developed the drug, strongly implying she had worked on the same drug as well.[](#cite_note-821p7-4) Lastly, [Vermouth](/wiki/Vermouth "Vermouth"), who opposed the Miyanos' research, seems to have transposed her distaste onto Shiho's research and Shiho herself.[](#cite_note-10)
It is also notable that Vermouth has been a part of the Black Organization long enough to have heard the Miyanos use the name "Silver Bullet",[](#cite_note-11) and may have given Conan the same nickname in reference to his deaged state caused by the drug.