Prototype Antidote

The first known temporary antidote for APTX is *[paikaru](/wiki/Paikaru "Paikaru")*.
The **prototype antidote** (解毒剤 ,*gedoku-zai*[?](/wiki/Help:Japanese "Help:Japanese")) temporarily restores the body of someone de-aged by [APTX 4869](/wiki/APTX_4869 "APTX 4869") to their true age and appearance. The prototype antidote is created by [Shiho Miyano](/wiki/Shiho_Miyano "Shiho Miyano"), the original creator of APTX 4869.
## Contents
* [1 Description](#Description)
* [2 Appearances](#Appearances)
+ [2.1 Canon](#Canon)
- [2.1.1 The Desperate Revival](#The_Desperate_Revival)
- [2.1.2 Murderer, Shinichi Kudo](#Murderer.2C_Shinichi_Kudo)
- [2.1.3 Holmes' Revelation](#Holmes.27_Revelation)
- [2.1.4 The Shadow Approaching Haibara's Secret](#The_Shadow_Approaching_Haibara.27s_Secret)
- [2.1.5 Kyoto School Field Trip Case](#Kyoto_School_Field_Trip_Case)
- [2.1.6 Sisters' Birthday Party Murder Case](#Sisters.27_Birthday_Party_Murder_Case)
+ [2.2 Non-canon](#Non-canon)
- [2.2.1 The Stranger from Ten Years Later](#The_Stranger_from_Ten_Years_Later)
* [3 Speculation](#Speculation)
* [4 Quotes](#Quotes)
* [5 Trivia](#Trivia)
* [6 See also](#See_also)
* [7 References](#References)
## Description[[edit](/wiki/index.php?title=Prototype_antidote&action=edit&section=1 "Edit section: Description")]
The animation effect shown when the prototype antidote is either taking effect or wearing off.
Taking a prototype antidote causes [Conan Edogawa](/wiki/Conan_Edogawa "Conan Edogawa") and [Ai Haibara](/wiki/Ai_Haibara "Ai Haibara") to return to their original adult bodies for a short duration. The antidote lasts longer and has fewer side-effects than *[paikaru](/wiki/Paikaru "Paikaru")*; the ones shown so far have typically lasted for about 24 hours or less. The transformation occurs as soon as the pill is taken, and there are no complications during the majority of the time that the antidote is in effect. However, when the antidote begins to wear off, Shinichi feels feverish, sweats profusely and experiences increasingly acute chest pain and heart palpitations. Shinichi reverts back into Conan soon after this.
Most of the times when Conan and Haibara have taken the prototype antidote, they were sick to some degree. It is unclear whether being ill is a requirement for the temporary antidote to act properly.
Unfortunately if a subsequent antidote dose is taken directly after the original dose, it works for far less time than the original dose. Taking the antidote frequently makes it less effective and shortens the active duration. Haibara cautions Shinichi that taking it consecutively will cause his body to develop resistance to it.[](#cite_note-1)
Ai Haibara developed the first prototype antidote after she discovered that consuming *paikaru* will temporarily restore a person shrunken by APTX 4869 to their original size.[](#cite_note-2) While Haibara herself never directly states extracts of *paikaru* are part of the antidote, Conan implies that it is one component.[](#cite_note-ep194-3) It is also likely Haibara used APTX 4869 data she copied from the [Black Organization](/wiki/Black_Organization "Black Organization")'s files as part of the prototype antidote development process.[](#cite_note-4) Haibara characterizes these prototypes as quite dangerous. She cautions Shinichi that he could die when he tries it for the first time.
Haibara keeps a small stash of prototype antidote with her in a pill box in case a situation arises where she or Shinichi need to become adults. She withholds these extra from Conan, citing his tendency to misuse them or publicly appear as Shinichi.
## Appearances[[edit](/wiki/index.php?title=Prototype_antidote&action=edit&section=2 "Edit section: Appearances")]
### [Canon](/wiki/Canon "Canon")[[edit](/wiki/index.php?title=Prototype_antidote&action=edit&section=3 "Edit section: Canon")]
#### [The Desperate Revival](/wiki/The_Desperate_Revival "The Desperate Revival")[[edit](/wiki/index.php?title=Prototype_antidote&action=edit&section=4 "Edit section: The Desperate Revival")]
A series of incidents led [Ran](/wiki/Ran "Ran") to believe Conan is actually Shinichi who had been somehow shrunken. Before Conan could tell Ran the truth, Haibara reveals to Conan that she has developed a temporary antidote. After warning him that the temporary antidote was untested and could kill him, Conan agrees to take it as part of a trick to fool Ran by having both Conan and Shinichi appear at the same time. Shiho dresses up as Conan, and Shinichi secretly enters the school play as the mysterious Black Knight who would kiss the heroine played by Ran. Despite a murder interrupting the play, Ran saw both Conan and Shinichi at the same time, fooling her into no longer suspecting Shinichi and Conan were one and the same.[](#cite_note-5)[](#cite_note-6)
The antidote ran out unexpectedly just before Shinichi was able to confess to Ran that he loved her.
#### [Murderer, Shinichi Kudo](/wiki/Murderer,_Shinichi_Kudo "Murderer, Shinichi Kudo")[[edit](/wiki/index.php?title=Prototype_antidote&action=edit&section=5 "Edit section: Murderer, Shinichi Kudo")]
After this scene, comes to where Shinichi almost confesses, this time his body here with Heiji's cap only lasting four hours.
Shinichi accidentally took the antidote prototype when [Professor Agasa](/wiki/Hiroshi_Agasa "Hiroshi Agasa") mistook it for cough medicine. This worked out to Shinichi's advantage because the culprit was in disguise as Shinichi, trying to implicate him for a crime. Shinichi was able to appear as himself and reveal the culprit's trick. The antidote wore off after 24 hours, forcing Haibara to give Shinichi another one to protect his identity. The second one wore off in a shortened 4 hours, again interrupting Shinichi's confession of his feelings to Ran.[](#cite_note-7)[](#cite_note-8)
#### [Holmes' Revelation](/wiki/Holmes%27_Revelation "Holmes' Revelation")[[edit](/wiki/index.php?title=Prototype_antidote&action=edit&section=6 "Edit section: Holmes' Revelation")]
Shinichi on the plane after taking the pill.
Conan is given the antidote so he can fly to London, because the alias *Conan Edogawa* does not exist and has no passport.
Haibara passes to Conan a second pill for the trip back to Japan. However, after Conan accidentally reveals Shinichi is in London, Shinichi (as Conan) is chased by Ran, who doesn't know she is actually chasing Conan, but thinks it's Shinichi she chased. Conan hides in the booth and ingests the return-trip pill, and walks out of the booth. A bawling Ran runs away, and Shinichi runs after her. He grabs her arm and pulls her in front of him at the Big Ben, and this time nothing stopped him from confessing his feelings, somehow.
Fortunately for Shinichi, after he turns back to Conan and apprehends the terrorist together with [Minerva Glass](/wiki/Minerva_Glass "Minerva Glass"), his parents [Yusaku](/wiki/Yusaku_Kudo "Yusaku Kudo") and [Yukiko](/wiki/Yukiko_Kudo "Yukiko Kudo") appear, giving him the third pill under orders from Haibara. He then goes back to Japan.[](#cite_note-9)[](#cite_note-10)[](#cite_note-11)
#### [The Shadow Approaching Haibara's Secret](/wiki/The_Shadow_Approaching_Haibara%27s_Secret "The Shadow Approaching Haibara's Secret")[[edit](/wiki/index.php?title=Prototype_antidote&action=edit&section=7 "Edit section: The Shadow Approaching Haibara's Secret")]
Shiho takes her first temporary antidote to break down the door of a burning shack to free herself and the Detective Boys. She hides in Agasa's camping tent until it wears off.
#### [Kyoto School Field Trip Case](/wiki/The_Scarlet_School_Trip "The Scarlet School Trip")[[edit](/wiki/index.php?title=Prototype_antidote&action=edit&section=8 "Edit section: Kyoto School Field Trip Case")]
To go to Kyoto for the school field trip, Conan took the antidotes provided by Haibara. Here Haibara provided Conan instructions when using multiple antidotes that he needed to wait 8 hours after being shrunk before taking the next one. Haibara added a footnote saying not to do anything too intimate while in the original body, although it's unclear whether it is related to the antidote.
#### Sisters' Birthday Party Murder Case[[edit](/wiki/index.php?title=Prototype_antidote&action=edit&section=9 "Edit section: Sisters' Birthday Party Murder Case")]
Mary receives a call from Masumi, informing her that Conan brought the antidote that can returns her to her orginal body, and it is blue and white compared to the drug she was forced to take, which is red and white. Mary ordered her daughter to steal the antidote if possible. Later, Mary calls her daughter, asking if she was able to get the antidote, which Masumi responded that she was involved in a poisoning murder case. Hearing about poison, Mary started to remember her shrinking moment. Several months ago, Mary was supposed to meet her husband at Vauxhall Bridge in London, [Tsutomu Akai](/wiki/Tsutomu_Akai "Tsutomu Akai") appeared in front of her, however Mary realised that he isn't her husband after giving him false informations about her daughter. Tsutomu is revealed to be [Vermouth](/wiki/Vermouth "Vermouth") in disguise, who intended to poison her with [APTX 4869](/wiki/APTX_4869 "APTX 4869"). Vermouth feeds Mary the drug with her mouth directly, which is created by her [sister](/wiki/Elena_Miyano "Elena Miyano"). Mary then jumps into the river due to the effect of the drug being very instant. After Mary shrinked, she returned to Sera, explaining to her the whole situation. Later, Mary and Sera witnessed Conan proclaiming himself as Holmes' apprentice during [Minerva's match on TV](/wiki/Holmes%27_Revelation "Holmes' Revelation"), and remembered the same proclamation of Shinichi ten years ago. The two realised that Conan is Shinichi who shrunk the same way as Mary, however, he has a way of returning as Shinichi to board a plane to London. Since then, Mary ordered Masumi to get closer to him, in order get their hands on the antidote. However, Masumi failed.
### Non-canon[[edit](/wiki/index.php?title=Prototype_antidote&action=edit&section=10 "Edit section: Non-canon")]
#### [The Stranger from Ten Years Later](/wiki/The_Stranger_from_Ten_Years_Later "The Stranger from Ten Years Later")[[edit](/wiki/index.php?title=Prototype_antidote&action=edit&section=11 "Edit section: The Stranger from Ten Years Later")]
The antidote Shinichi tried was a failure. Although he transformed, he was unconscious the whole time and had a vivid dream where he was still stuck as Conan a decade later. When he woke up, he transformed back to Conan.[](#cite_note-12)
## Speculation[[edit](/wiki/index.php?title=Prototype_antidote&action=edit&section=12 "Edit section: Speculation")]
While thinking about how to make a permanent antidote, [Conan](/wiki/Conan "Conan") speculates that *paikaru* ingredients are not enough. Haibara adds that the APTX 4869 data is needed as well.[](#cite_note-ep194-3) Haibara in fact does have at least some APTX 4869 data. She copied some onto a floppy disk while [she was locked in a room with Pisco's computer](/wiki/Reunion_with_the_Black_Organization "Reunion with the Black Organization"), but then lied to Conan that she lost it.[](#cite_note-13) Thus, there is some speculation that Haibara may have developed a full antidote, but is withholding it from Shinichi.
## Quotes[[edit](/wiki/index.php?title=Prototype_antidote&action=edit&section=13 "Edit section: Quotes")]
> *Give.* — [Conan](/wiki/Conan_Edogawa "Conan Edogawa"), asking Haibara for more and more pills.[](#cite_note-14)
> *Taking one too many will thus render it (the pill) useless.* — [Ai Haibara](/wiki/Ai_Haibara "Ai Haibara"), convincing Conan
> *He'll probably use one for Ran, so...* — [Ai Haibara](/wiki/Ai_Haibara "Ai Haibara"), telling Shinichi's parents to bring a third pill to London
## Trivia[[edit](/wiki/index.php?title=Prototype_antidote&action=edit&section=14 "Edit section: Trivia")]
* The antidote pill appeared in [Episode 1054](/wiki/The_Spark_That_Fell_on_the_Ranch "The Spark That Fell on the Ranch") blue and white contrast to APTX white and Red color scheme.