lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Specifically methylates the 2'-O-ribose position of uridine-2479 in 23S ribosomal RNA. Confers resistance to antibiotic avilamycin, an orthosomycin antibiotic.
Sequence:
MARSRGERTPAARRITSRNARFQQWQALLGNRNKRTRAGEFLVMGVRPISLAVEHGWPVRTLLYDGQRELSKWARELLRTVRTEQIAMAPDLLMELGEKNEAPPEVVAVVEMPADDLDRIPVREDFLGVLFDRPTSPGNIGSIIRSADALGAHGLIVAGHAADVYDPKSVRSSTGSLFSLPAVRVPSPGEVMDWVEARRAAGTPIVLVGTDEHGDCDVFDFDFTQPTLLLIGNETAGLSNAWRTLCDYTVSIPMAGSASSLNAANAATAILYEAVRQRISGRTATTP
The following text describes a protein:
Function:
Required for the addition of the long alpha 1,6-mannose backbone of N-linked glycans on cell wall and periplasmic proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=Cis-Golgi. Recycles between endoplasmic reticulum and Golgi.
Sequence:
MRVYNKSRIVGQLLFVALGITFIYYLFTPSVNSNAKVQIENRGGNSYEIYDMNKITESSDPIRNKEEVLILTPIARFYPQYWKNLLELDYPRNLISLGFIVPSSKDGAKVHRELRNAINAVQKGPGDKRFADVKILIQDSDLSSGQSEAERHKFSAQKERRGKLAATRNTLLLSTLKPSTSWVLWLDSDIVETPSTLIQDLAEHNEDVLVANCFQKQGDKLTPYDFNSWVDSQTAQELASHMDRDEILLEGYAELPTYRMLMAKIYEEHKDPSTIMALDGVGTTALLVKASVHRDGALFPTFPFYHLIESEGFAKMAKRLGHGVYGLPYYLVFHHNE
The following text describes a protein:
Function:
Orphan receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPPSCTNSTQENNGSRVCLPLSKMPISVAHGIIRSVVLLVILGVAFLGNVVLGYVLHRKPNLLQVTNRFIFNLLVTDLLQVALVAPWVVSTAIPFFWPLNIHFCTALVSLTHLFAFASVNTIVVVSVDRYLTIIHPLSYPSKMTNRRSYILLYGTWIAAFLQSTPPLYGWGHATFDDRNAFCSMIWGASPAYTVVSVVSFLVIPLGVMIACYSVVFGAARRQQALLYKAKSHRLEVRVEDSVVHENEEGAKKRDEFQDKNEFQGQDGGGQAEAKGSSSMEESPMVAEGSSQKTGKGSLDFSAGIMEGKDSDEVSNGSMEGLEVITEFQASSAKADTGRIDANQCNIDVGEDDVEFGMDEIHFNDDVEAMRIPESSPPSRRNSTSDPPLPPCYECKAARVIFVIISTYVLSLGPYCFLAVLAVWVDIDTRVPQWVITIIIWLFFLQCCIHPYVYGYMHKSIKKEIQEVLKKLICKKSPPVEDSHPDLHETEAGTEGGIEGKAVPSHDSATSP
The following text describes a protein:
Function:
[Tau-AnmTX Ms 9a-1]: Acts as a positive modulator of mammalian TRPA1, a non-selective cation channel involved in detection of pain, in vitro yet has an analgesic and anti-inflammatory effect in vivo.
Subcellular Localization:
Secreted. Nematocyst.
Sequence:
MKQSLILAVLCLALVFATIEAKPKADPNIIVGGCIKCHVKNASGRCVRIVGCGVDKVPDLFSDPNIIVGGCSKCHKQDSSGNCVRIAGCGVDPVRDAE
The following text describes a protein:
Function:
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Required for assembly of the cortical actin cytoskeleton and for hyphal growth.
Subcellular Localization:
Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Cell tip. Note=Localizes in patches that are found concentrated at the hyphal tip.
Domain:
The N-terminal SH3 domains are important for actin cytoskeleton assembly but not for localization.
Sequence:
MSSIYIGVYKALYDYAAQAEEELNIKQNDLLYLLEKSDIDDWWKVKKRVVATGEEIVDEPSGLVPSTYIEEAPVIKTATALYDYDKQTEEELSFNENDKFNVFDLNDPDWILVGDLAKEKFGFVPSNYIQLDSTAEPAQHQQQQPQQVFQPPPQQQQAIPQQQTQIPINNFPPPPTHKDRTPDFPAPPAHRDRSPEHPPPTPEKDYPRMFEQEPRSLGSRYDRQPEGREEEEDEAPPPMPSRPTGSNIVAPEPVVGRSNTYEQEENVEHSEHSYDGEFFTWYIDEVDGRKKRAIKLSIGQGLVIIKPNTTNPKKLRMRSSSSLDNQWRIKDLITFNNEKKHVFLEFKNPAASLELHAGSKDVAEAIMAILGDLKGAEAAHGLREVAKASKASANERNRKIGRLLYDFEVQGDDELDCKEGDEVYIIDQKKSKDWWMVENIATRRQGVVPSTYIEIISTSNLDKLTDGPLRRKSTKSKGRVVETKDKRSSHHRTREERDRIREKDRAQRDKAPTSQTEQDKSMPNFHRVRTWIDSSGTFKVEAEFLGCVEGKIHLHKTNGVKIAVAADKLSVEDLEYVERVTGTSLEQYKEQVMKQQAKRAKSKSKSGATATPSSTNETKYASSATAAINDIAPPKPTRPQTTTQVSNNGAPLYDWFDFFLECGVDIGNCQRYTLNFEREQMDENILEDISPSLLRTLGLREGDIIRVMKYLDAKFDRKKTPEAPQQNGGLFIDKNGNLKNNSSSTEISKVSADALPSPVKTQVTSFTPVNESTQNNNKIEDDAWAMKPAARSSEDLLKPSPQPQTPQYTGALSDLVNIKPVGTSNENKAKTEQIPVEPSAPALQPMKTSNTAATSSIPPQGPGVTPQRTGTLVPVQKTGGLVPVQRTGAGLVPVQTGGYLPAQPTGFVPITAQPTGFIPIQATGILQPQLTFGIVPLQTGTSTFNANNKTAPPRPDTAPPPITTFGQQPTFQPAFVPLQTGVITMPQTTFGGQSQQLPTQITGGAPPQTSFNQPALVPTQRTGGQITGGFVPQSNFGKQITGGFMDTNTLSFGQQITGNAQQQPPPSTSFGQQITGGLPATSFGQQITGGFPQTSFGQQMTGGAPQTSFGQHITGGNMPNTSFGQPFSQQATSNPFPQMANQFTQQQQYQQQQPVMNQFQQQPQQQQQPFYNQFQSQPNLNQMTNMFQNTSISSPATFNQQIPTTTFGQQPQFEGFGSQPLQSQPTGMGFGNAPLQSQPTGKRANLQAATPDNPFGF
The following text describes a protein:
Function:
May be involved in the biosynthesis of molybdopterin.
Sequence:
MPSNLEFIPLHLCVLTVSDSRTLADDRSGDYLVDALTHEGHVLHARALCPDDRYRMRAIVSAWIADAQVDGILVTGGTGFTGRDSTPEAITPLLDKLMPGFGEMFRAISVAEIGTSSLQSRAFAGLANHSFVFCLPGSTSACRTAWEKIVRAQLDARTKPCNLATLRPRLSE
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MERDFLGAIGHEQQQQQRQRAAAEDDAARKESAYFGGGGVPPMDWSFAGRAGAAPAVMSFRSAAREEQQQQQGELAFSKQQASRVLTPQRSFGAENHGSVQYAAAARAAYGGQPPQQQHAPNGARVIPMSSPFNPNNPMFRVQSSPNLPNGVAAGSPFKQPPFAMNNAVAASTVGVYKSRDMPKPKTAQLTIFYAGSVNVFNNVSAEKAQELMFLASRGSLPAAPSTVTRSPDATFFTPAKLAAPELSPAKQMLPQMPQRVSPPLSGISKPISMVSQAACVPKSASSSNIDSTAPKSSGQLVVPPTSQPSSSTHPVTLASTTAASIMPRAVPQARKASLARFLEKRKERVTTTAPYPSAKSPMESSDTVGSANDNNSKSSSCTEIAFSSNHEESLRLGGRPRNISFSGESPSTKLHI
The following text describes a protein:
Function:
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).
Subcellular Localization:
Membrane, clathrin-coated pit.
Domain:
The ENTH domain coordinates with the clathrin-binding C-terminal domain to allow a dynamic interaction of epsin with coated pits.
Sequence:
METMIKSYIKKGKDAVLNTPEIERKVRDATSNDKWGPSGTQMQEISRASYNYECFPIIMGVIWKRINDPGKFWRHVYKSLLLIDYLVRNGSPQVIRDCRHHTMEIKTLVEFQYIEEEKDVGLSVRERAKQVIDLLQDDQRIKEERDKAKTNQNKYVGIGNDSRDFGYGGGSYGGGGYDSDSYGSNQRDSYGGNQRDSYGGNQRDSYGGNQRETTRRDSFNGRDEGYGNNNNNNNNNSYDSDPYSNTRAEYENYSNRAETRRNNEFGDDSNNSYNNNNNFNNNNNNNNSYNNSNNSNNSNNNNNNNNYNNSNNNSNNIQNNPNAASGGRSRPRAASGSGPSPATPNFQSSQQQQQPTLIDFSEPTPANKPMVFDPLADLASGMNNTNNNNNNNNNNSNSFGGFQSVNNNQNSFNFNNNNQQQQQQNNFLQLTQSNPQQSNNNNNNNNFFNQQPQQAQQFGQFQNSSMNKDPFAKDEFGDFAGANGNADFNPFDQQSGDFSNKNDGQQKPKDTNDPWSKKDLFDLSNLGNQNPNQSPVNNTNNNNNGNTRSQPARVANGPITSAGSTIPTMRPQPMMNQGFNGGMMNQGMGGFNQGGGMNNMNGMNQGGMNNMNGMNQGGMNQGGMGGFNQGGMNNMGGMNQGGMNNMGGMNNMGGMNSMNGMNQGGMGFNQSGANRNTNSMGSAGRF
The following text describes a protein:
Function:
Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6-(bis)phosphate (beta-G16P) as an intermediate.
Miscellaneous:
MISCELLANEOUS: The catalysis proceeds via a phosphoenzyme formed by reaction of an active-site nucleophile with the cofactor glucose 1,6-diphosphate (G1,6-diP). The phosphorylated mutase binds either G1P or G6P and transfers the phosphoryl group to the C(6)OH or C(1)OH, respectively.
Subcellular Localization:
Cytoplasm.
Sequence:
MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKGISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQLKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDVSPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQYRIRESIP
The following text describes a protein:
Function:
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Chemoreceptor for inorganic phosphate, which is required for taxis at high concentrations of phosphate. Recognizes inorganic phosphate directly. Can also bind to other components that have a pyrophosphate group, including ATP and ADP.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
Binding to inorganic phosphate induces dimerization and stabilization of the ligand binding domain.
Sequence:
MPASPGHRDVLGCLVAACVPVQPGNPSRRSMLQQSLRAQILVLLGGSLAALLLIALACFGSLTGDVRAYRELLGGPVRAAQLIDEANLQFRGQVQEWKNVLLRGRQTEAQTKYWSQFEAQERAVQDILGRLGSVAEGELKDRVERLREEHRRLGTAYRQGRQRFLEAGADPIAGDQAVTGIDRATTAQMQTLRDELHQASDLHSSSISAEARRTMLLGSLVLIGASLAVALLSLWLVNRNLVRPVQRLIEHIAQLSHGDFGERIEIRRKDELGKLALAANTLRDFLVDIFDRLRRSTRDLDSASGSLNAIASLMAAGTREQFSRTDQVATAMQEMSATAQEVARYAGDAARAADEADDSAQRGEDVMEETIRSIGEMRKEIDHTVEVIRQLESDSGRIGKVLDVIRGIAEQTNLLALNAAIEAARAGDAGRGFAVVADEVRTLAQRTAESIAEIHQIIDTVQNGAVNAARAIESGQSRSEAGAEQVANAGAMLRQITASVESIRDMNRQIATAAEEQTAVAEEISRNLTEIASIASSNQEQVEQTEAASRDLHGLSAQLGDALQRLRA
The following text describes a protein:
Function:
Required for sperm acrosome biogenesis.
Subcellular Localization:
Nucleus inner membrane; Single-pass type I membrane protein.
Sequence:
MRTLLRWCLFLSLCVSCACAFMFSSMREKTKESPGKVPCGGHFRIRQNLPENAQGWLGNKWLWLFVAIMIYVMLKFRGDGENKEQHPPGLRGCQLRSPPKKAQNISPSKDFTFNTLTQLEMELVKFVSKVRNLKVSMATNSNSRQQVPESPTNLYNNVTIYEIWGEEDSE
The following text describes a protein:
Function:
Involved in cadaverine and putrescine tolerance in stationary phase. May facilitate the efflux of both cadaverine and putrescine from the cytoplasm, reducing potentially toxic levels under certain stress conditions.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLNSILLILFLIAVSAFFSLSEISLAASRKIKLKLLADEGDTNALRVLKLQETPGMFFTVVQIGLNAVAILGGIVGDAAFSPSFKLVFERFMAPELADQASFVCSFVLVTSLFILFADLTPKRIGMISPEAVAVRIVNPMRFCLMIFRPLVWFFNGMANLIFRLFKLPMVRNDDITSDDIYAVVEAGALAGVLRKQEHELIENVFELESRTVPSSMTSRENVIYFDLRESEDSIKDKISTHPHSKFLVCDGHIDQVVGYVDSKDLLNRVLGNQSLVLSSGVQIRSALIVPDTLTLSEALESFKTAGEDFAVILNEYALVVGIITLNDVMTTLMGDLVGQGQEEQIVARDENSWLIEGGTPIEDVMRVLHIDDFPQSGNYETIGGFMMYMLRKIPKRTDFVKYAGYKFEVVDIDSYKIDQLLVTRLSDQPAPILPKAPHESSDA
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Miscellaneous:
MISCELLANEOUS: Present with 377 molecules/cell in log phase SD medium.
Sequence:
MRSSKSPFKRKSHSRETSHDENTSFFHKRTISGSSAHHSRNVSQGAVPSSAPPVSGGNYSHKRNVSRASNSSQTSNFLAEQYERDRKAIINCCFSRPDHKTGEPPNNYITHVRIIEDSKFPSSRPPPDSKLENKKKRLLILSAKPNNAKLIQIHKARENSDGSFQIGRTWQLTELVRVEKDLEISEGFILTMSKKYYWETNSAKERTVFIKSLITLYIQTFEGHVPELVNWDLSLFYLDERSYQRAVITNRPGSVSPIKSPTSNFTTNTTQSVGSVPFSAPTERTRRSETESVNPVSTPASVEYHAGMKSLNKAPYSSNSTLNEVNKRYELEQQQQQEEAELRRLEEQKRLQLQKENEMKRLEEERRIKQEERKRQMELEHQRQLEEEERKRQMELEAKKQMELKRQRQFEEEQRLKKERELLEIQRKQREQETAERLKKEEQEALAKKEEEEKSKRNKVDNESYTQEINGKVDNLLEDLNAVLAEETETTPTMQNGTYVPERSTARAHDQLKKPLNIAKVESLGGSDLNDSISLSDEIAGLNTSNLSGEDQDEKNDLSFEKGDEVRYSNNFEGEAPHVYHEVSIIQEEAPAVSQKLILPEENNESEALIESKEEIKTMENIDDEVLLEILTDINWSIEDDADSMIERIDLRLAETEYLFNQNLLSLQKIGPNIRPYEDKVNDECHRIIPTLSLFLMEMSNFSNDIENVESQDNGLQVESANKKLLWNTLDELLKTVSLDEISLNQLLECPIREKNLPWMENQLNLLLKAFQAIGSDGNEVEYNLREISGLKQRLQFYEKVTKIFLNRIVEEMQKKFSNIRGQDISHDQMIRILTTLLIFSPLILFCKEISQKSYQAIVENWNVSIQPVYMELWTKKISQLQGIDTNDEKMNELSLSQLLNEWDTFRKERKTNDINPVFKNSFSLLTECLQTMRQECIVYQNFVEVFFHISSKHNFEEYIKHFNDPDAPPILLDTVKVMQSDREAAVIETQLVSRIFQPIVTRLSSYFVELVKAEPTVAPALTFYLENEIKSLESSNHEFLLSAVTRMYTQIKQVWSDNVEEQVLHFERISNATTNGEILPGILDLPVGLKNSEDLFQFAKRSMDIKDTDEGYESIELMNSSFRKLSIAATRSITHKEVNSSINPNLSDTAALNNDYMETISLLVNSNWLTEMLSMLNFNKDGIFDTSLQNVKKVFDVEKESYASFLLRDTMPKLTAFVYGVSNIIENTNNVNMTNPSRWAAYSRQNLENILLAYTSHEIETLVKRLHTHMVNDFGYHQENAINNVLCDKLWSCIQGQTVSLYLKLYTVIDKHYRGTNIRFTKNDIISAFEEYKNA
The following text describes a protein:
Function:
ssDNA-binding protein that probably contributes to the ionizing radiation resistance of D.geothermalis. Plays a role in DNA repair and genome reconstitution, in a RecA-independent process, and is necessary for recovery from severe genomic fragmentation as a result of exposure to severe levels of ionizing radiation (Probable). Binds single-stranded DNA but not duplex DNA.
Domain:
Contains a novel ssDNA-binding fold, which is structurally and topologically distinct from the OB-fold universally found in standard SSB proteins. The disordered C-terminus of DdrB may mediate interactions with other proteins important for DNA damage recovery.
Sequence:
MLHIEFITDLGAKVTVDVESADKLLDVQRQYGRLGWTSGEVPVGGYQFPLENEPDFDWSLIGARKWTNPEGEEMILHRGHAYRRRELEAVDSRKMKLPAAVKYSRGAKNTDPEHVREKADGEFEYVTLAIFRGGKRQERYAVPGSNRPQAGAPARSAATRAQGARPGAVAVQDEETPF
The following text describes a protein:
Function:
May function as a signaling molecule by regulating the trafficking of other regulators.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasm.
Sequence:
MSNIKLGVEVISAQGLLQRDKHNSCSPFVELKFDNQIFRATTKHNDPNPVWHECFYFVVSDPSVLSTRTLEAHVYSYQNEFDAKPFLGKVRVNGTSFVPRSEAAPFNYPLEKRSVFSRARGELCLRVFITDDPSVTPSVPTPVPESPQAYSPSPRKEHVKSLITADASMATDERRELKPKTRTFHNSAPLVKQQPMMNYGIHEMRAAPMPPRVVQVNGPGPSLHQLPPDFSVKETSPLLGGGRIVGGRVVRGTERPTSGTYDLVEEMKFLYVRVVKARDLPNKDLTGSLDPYVVVKIGNFKGVTTHFNKNTDPEWNQVFAFAKDNLQSNFLEVMVKDKDILLDDFVGIVKFDLREVQSRVPPDSPLAPQWYRLENKRGEKKNYEIMLAVWSGTQADEAFGDATFSDSLVDSDSSNIISANLRSKVYHSPRLWYLRVQILEAQDVIIVSDKSRVPEVFVRVKVGNQMLRTKFPQRSNNPKWGDEFTFVVAEPFEDNLVLSVEDHTAPNRDEPVGKAVILMNDIEKRIDDKPFHDRWVHLEDSISDAMDVDKAKKVKFATRLRYKAVLDGGYHVFDESMYNSSDLRPSSRKLWKPAIGVLELGILNANVFHSMKTREGKGTSDTYVVAKYGHKWVRSRTVINSMNPKYNEQYTWEVFDPATVLTICVFDNAHFAAGDGGNKRDQPIGKVRIRLSTLQTGRVYTHAYPLLVLQPTGLKKRGELHLAVRFTCTSVSSMLMKYTKPLLPKMHYILPLSTNQQEALKMQAINIIIVRLGRSEPPLRREVVDYLTDWKSQLFSMRRSKANFNRFTTVFSGALSVWKWMEQVCTWKTPVTTALVHVLYTMLVTFPEMILPTVFLYMAVIGMWNYRFKPRFPPHMDAKLSYADNVNSDELDEEFDTFPTVRAPDIVKMRYDRLRSVAGKVQSVAGDIAAQGERVQALLSWRDPRATAIFVTFCFIIAMALYITPFKLVALLSGYYFMRHPKLRHRIPSAPVNFFRRLPAMTDSML
The following text describes a protein:
Function:
Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells.
Sequence:
XGASQGLHALLEERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINEDEIPPPVALGKRPLAPQEPANRSPETDPPAPPALESDPDPRALLSSRQREYKVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLKPQQASQAPTAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARSGGDERKARMHERIAKQYQDAIRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAATLAAAEKLASAEDSAPADKDEDEGEPPAQAPVAKKPARPTVPSSQRLPEPRASSSKESPSPSVREQLALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKWLEAQIIQARSGRPVDLSKVPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFMHQGNVAETTRFEKLAQDRKKQLEILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMHLIIVRGMNLPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNINRNHRGFKRVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPTGGKLEVKVRLREPLSGQDVQMVTENWLVLEPRGL
The following text describes a protein:
Function:
Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Appears to have a role in recruitment of telomerase and CDC13 to the telomere and the subsequent telomere elongation. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.
Miscellaneous:
MISCELLANEOUS: Present with 892 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MRSVTNAFGNSGELNDQVDETGYRKFDIHEGILFCIELSETMFKESSDLEYKSPLLEILESLDELMSQLVITRPGTAIGCYFYYCNREDAKEGIYELFPLRDINATFMKKLNDLLEDLSSGRISLYDYFMFQQTGSEKQVRLSVLFTFMLDTFLEEIPGQKQLSNKRVFLFTDIDKPQEAQDIDERARLRRLTIDLFDNKVNFATFFIGYADKPFDNEFYSDILQLGSHTNENTGLDSEFDGPSTKPIDAKYIKSRILRKKEVKRIMFQCPLILDEKTNFIVGVKGYTMYTHEKAGVRYKLVYEHEDIRQEAYSKRKFLNPITGEDVTGKTVKVYPYGDLDINLSDSQDQIVMEAYTQKDAFLKIIGFRSSSKSIHYFNNIDKSSFIVPDEAKYEGSIRTLASLLKILRKKDKIAILWGKLKSNSHPSLYTLSPSSVKDYNEGFYLYRVPFLDEIRKFPSLLSYDDGSEHKLDYDNMKKVTQSIMGYFNLRDGYNPSDFKNPLLQKHYKVLHDYLLQIETTFDENETPNTKKDRMMREDDSLRKLYYIRNKILESEKSEDPIIQRLNKYVKIWNMFYKKFNDDNISIKEEKKPFDKKPKFNI
The following text describes a protein:
Function:
May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.
Miscellaneous:
MISCELLANEOUS: Present with 736 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MAPKISISLNPPYNGEFYSSNDQMSGIVSLQLTKALSIRKISVILKGFSETLTKIDQEYMFQQNGMMMPGQDNKSFHTLMKFEQRVFPPDNVWNALDGSSKPFKVKPGSYNYSFQFDKFPRKPECLKNHTAKTVAFVTRSNARLPPTFNSHWQEFNKIDNLDLYFYSFGKVIYMVQVQLELGKSSSWFKPFHKLIREIETFEFIPEPKDLIIEPDEDDNEELNAFSNNSRGNSMVTNNEFFNSSNLKVPSKDVKVVNGVGYIKSDRNFSQANSILIENGDIRSRPVSSVTSTRQSTRLVNGMKVFPSTYKMGLPDGESNMRIEVRSRDLKQIYRKDYLFRSGSQNFDKVYVVMEGNIASLSKMQITPLKLQLNLLETTTYLSQGIANGNYSSLKLIEIDLNQLKSNKPLLDLNEIRENFDGSMFECELRLKDHPILRKLVFNEEDYRHRGNRLYSFKTCTIKRTFSLQLLIEWGINGIRKQSEVNIDPVQIFCQVREHVEAEALPRYVPPPTYTEMAS
The following text describes a protein:
Function:
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Subcellular Localization:
Nucleus.
Sequence:
GRMVVEVENFFGVYMLYCTNPKFKGRIYIGFTVNPERRIGQHNGGRQRGGAKRTSGRGPWEMILIIHGFPSDIAALRFEWAWQHPHSSRRLAHVARKSRRESSLEFHWRVVSHMLRVAPWSRLPLTARWLKQEYRLDFEPALQPPLHVPIAFGSVRAKKTSGREPGTLATGTEKCVLCRESIELSEDLLCCFHPSCHMTSHVTCLAKHFLQAEPAHLLPVEGICPGCESPVLWGSLIRYKKGCYGDLEEISASSQSHWADELQL
The following text describes a protein:
Function:
Involved in auxin transport. Regulator of the auxin signaling pathway.
Subcellular Localization:
Cell membrane.
Sequence:
MHKSKRNPSFSSTLLDEIYNSIDPKTQKTQPYVGSVNTTTKKQSIVTRSVPDRKIHRDRFFGSVSSSSDSNSSIFSSSDTELTHGKKTTSSRPLCFGPSKTKPRKTEDKTLFHQNRATRVYDDYDYASDVPKFNRHDENWENTRNRRSVKSSGNQKKPKTPASPGGRIVNFLNSLFSNNSKQSNAVKSYPRKTSYDDSAYVRKTSNDYHSSTTTCSSASSFSRSCMNKGYEKSSGRIKRSVRFSPVNVIVPESFTSKEEDYFSNGNARKSVKKNVEDGGRRSVEEIAREFLRDYHKNHENSLVKTNGFEDYEDDDEDDDDDDVASDSSSDLFELDLVGNHHHHNVYGDELPVYETTFAGLIL
The following text describes a protein:
Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSWSPEECRDQGEPQGNRYSLCARLVEKPDRAPEENPEPGLGPIIVRKASGPALAFWQAVLVGDVGSVSQILSDSSTGLAPDSTFDTSDPERWRDYRFNIRALRLWSLTFEEELTTPLHVAASRGHTEVLQLLLRRRAKPDSAPGGRTALHEACAAGHAACVHVLLVAGADPNTPDQDGKRPLHLCRGPGILECVELLLKFGAQVDGRSEDEEETPLHVAARLGHVELADLLLRWGACPHVRNSEGWTPLLTACDARCQSPVDAEATANRCFQLCSLLLSVGADADAANQDKQRPLHLACRHGHSAVVQLLLSCGVSANAMDYGGHTPLHCALLGPTTALAHSPEHIVRDLLNYGAVRVWPGALPKVLDRWCMSPRTIEVLMNTYRVVQLPEEAKGLVPPEILQKHCGFYSSLFALVKQPRSLQHLCRWALRTHLEGRLPHALPRLPLPPRMLRYLQLDFEDLLY
The following text describes a protein:
Function:
Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MSVRNSSIVRMSGTIVVLLGLVVLGITQGHEDADNMVQLDGGQFDMGTKASDGKDGESPVRQVKVLPFAVDKYPVTNKDFREFVRAKKYKTEAEAFGWSFVFEDFVSEELKKKVTQKLESAPWWLPVERAFWRQPAGPASGIKEKLDYPVVQVSWNDAQAYCKWLGKRLPTEEEWEFAARGGLKGKVYPWGNTFKPNRTNLWQGTFPGMDTATDGYHGASPVAAFPAQNEYGLYDMLGNTWEWTATEYTSARAQKQNKENMYVLRGASWIDTVDGSANHKARVTTRMGNTPDSASDNLSFRCAKNRRKSKTEDKMDL
The following text describes a protein:
Function:
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Sequence:
MKQKIVLATGNKGKVKEMADVLSDFGFEVIAQTDLGIESPEETGLTFVENALLKARYASEKSGLPAIADDSGLVVSALNGAPGLYSARYAGEEGNDAKNREKLLAELAHIAQEQRQAKFVSCIVFLQHPTDPSPIIAEGECCGVIGFEEKGENGFGYDSLFFSPEQGCTFAELETAEKKKISHRAKALSVLKSKL
The following text describes a protein:
Function:
Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-273 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins. In vivo target proteins include the heat-shock 70 family proteins hsp-1 and hsp-3 and the translation elongation factors eef-1A, eef-1G and eef-2. Can AMPylate core histone H3 in vitro (By similarity). Can also act as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from target proteins (By similarity). Decreases susceptibility to P.aeruginosa-mediated killing and might therefore play a role in the innate immune response (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Note=Predominantly localized to the endoplasmic reticulum and to the nucleus.
Domain:
The fido domain mediates the adenylyltransferase activity.
Sequence:
MSVRRRTHSDDFSFRLERTRRPSKLDVLRESPTLPVQQGYSLTTVVLVSLVVTLVCQNVAPPAFSYLNQLIKNSPKRKIPGQSNRLNIGFISTNSPEKFAPAVQKPTFLVDPIYDEKWKGVHTAVPVMTTEPEEKRDNNHAKVKEAILAAKAASRSRRDGNLERAVTIMEHAMALAPNNPQILIEMGQIREMHNELVEADQCYVKALAYDPGNSEALVLRARTNPLVSAIDRKMLKTVHDLRNEFAHLQHSTALRRMMRETYFLYVYHTVAIEGNTLSLGQTRAILESGMVIPGKSIREHNEVIGMDAALRFLNCSLLSKEHHEISIDDILEMHRRVLGNADPVEAGKIRTTQVYVGKFTPVAPEYVLEQLADMVDWLNDESTMAMDPIERAAIAHYKLVLVHPFTDGNGRTARLLLNLIMMRSGFPPVILPVETRAEYYASLHVANLGDLRPFVRYVAKHSEASIQRYIGAMKTSSGNVINGEEPNLTAEESKVSEKIETECRAGS
The following text describes a protein:
Function:
May be required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAARKNQKSPKPKVASSKLKNIKKSSKRNNSQSSTEPRKNATSLDSKKTTKKGVALPEIAERELTQEDIEFFNENPSSLKYLSSINPEDLGKKVEKGPRPDIYDLKKSQQFELDTSRLSSDEESVLDYSKDSEDEQDYELRPRVSSSWNNESYNRLPIKTKDGLLQNVVADVNNGEEFLSESESEASLEIDSDIKDEKQKSLEEQKIAPEIPVKQQIKNDKEALGIQAQQLLEEPVENLHLIRNIFEKFDSPYITIKKLSLLTLLAVFRDIIPGYKIRPLSEEEQGTKLSKEVAQRWEYEQTLLKHYAKFLQTLETILKSFSSTLDETQLSLYQVAVRCCTKLIEQASHFNLSEKLFALAVRQISHKTKRPGFDGIINSLKNIFEEDNLGKTSLKCVTILSRMFKQRNYDVLPDVYDLFLSVNILNDMKIKDEAWQDDTTNFKKRKKDLPYLTKKARKNYKETKKITQEMKEADAVITAQDKEKYQSEILKIIFITYFKTLQLKGKLIGNALEGVARLSHLLNIEFLGDLLQVLRELVMDDTVFLPKDKSGVQATREALLTVSTAFEIASAQGVGKLNLDLDLGLFVQRLYKIIFPFSLNPDADLNLKIKRLKDPDAPSKPFVVNATTEMEMLLKCFQVFFFKSKNISSSRLSSFSKRLAIASMQLPEHSASADLALLKKLLSRYSKLSRLLTSEEQIGDGIYNPFIEDPDLSNSSTAVLYEPFLLKNHYSPAVSQSAKELLKSTSL
The following text describes a protein:
Function:
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MTFSHRPVMPAEVLEYLSPRPGGVYVDGTLGGAGHARLILEATSPDGMLIGFDRDPAALEVARERLALFGERFRPVPGNFSEMGRVLAELGVDGVDGFLLDVGVSSHQLDTAERGFSFLTDAPLDMRMNTLVPGTAADLVNDLNEHELARIIKEYGEERWARRIASFIVKARVDGPIERTLQLVDIIKGAIPRGAWEERIHPATRTFQALRIAVNDELGSLERGLESALGLLRPGGRGVVISFHSLEDRIVKTMFRRYAQGCTCPKELPRCVCGGVPRLRILTGRPVVAGDVEVAENPRARSAKLRAAEKL
The following text describes a protein:
Function:
May play an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection.
Miscellaneous:
MISCELLANEOUS: Is not encoded in all strains, and seems to be dispensable for replication.
Subcellular Localization:
Host nucleus. Host cytoplasm, host cytosol.
Sequence:
MGQEQGTPWIQSTGHISTQKEEDGQKIPKLEHRNSTQLMGHYQKTMNQVAMPKQIVY
The following text describes a protein:
Function:
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MTGKKRSASSSRWLQEHFSDKYVQQAQKKGLRSRAWFKLDEIQQSDKLFKPGMTVVDLGAAPGGWSQYVVTQIGGKGRIIACDLLPMDPIVGVDFLQGDFRDELVMKALLERVGDSKVQVVMSDMAPNMSGTPAVDIPRAMYLVELALEMCRDVLAPGGSFVVKVFQGEGFDEYLREIRSLFTKVKVRKPDSSRARSREVYIVATGRKP