lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as a non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTENKTIIPTIIPVNVGVVLDDLHSWEDIWWSCIKMALKDFYASHVHYKTRLVLHSRDAKKNVVHAAAADTALDLIKNEQVQAIIGPVTSMETTFVINFGDQAYVPIISFSATSPSLHFEAPTLSNLHKMTHPKEVVPIYIDTPYGEDRFSLMPYKRLMPASPTKSVISPTATVDQITAELYKLQTTQTGVFVVHMTIELCSKLFTKAKEIGMMPHGYTFKIFLPFALPFDFIPFAKPDGTSAGSYDDLCYQVYLGKFDAVVGDTTTTSLASLYTFQQLQPSVTDIKDLVTKEESIGYLNNSYVYDILKHVGFDDSKIKGFRTMWEIDEALSKGSRKGGVAAVVDQTPNMKLSVAKYCSKYTMIGPIFKTDGFGFVRSLPSLYNTSILPFLIKEIDKPMRSMTGTERILDTEKKWFKEGRNCQDLNSPKVSSNSLGLESFWVLFLISGVASTLALIIFIASFIYRHRHILMHPADSEASTWRNILTMLKTFNEKDLTRRTFKLTSQSQDAVKASPSNISPQIVLCFMKRKRH
The following text describes a protein:
Function:
Inhibits cell division during the SOS response. Affects a later stage of the cell division protein assembly, after the assembly of the Z ring, by probably suppressing recruitment of FtsL and/or DivIC to the division machinery.
Subcellular Localization:
Cytoplasm.
Sequence:
MTLKLIWDKFYVSIIFVLTCIVLGIILMCTVVGGGSDYSEVNVNEGDSLWALADQYAGKSDMAKADFVSWVEKENNLSDGHVEAGDSVVIPVHKTKLLKSDSTIQLANQ
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MIQLLFMVLCLEGMVAFLLMVKIGPLRELVMKCLDQVKMRKGTVLTIAGTISAILFSNFISIIKIQNKGAKIGTMTPMDQVLWRTNLLEATLMGFSLFLGFLIDRMHHYLRKLIVLRSSAGSSKKEFERLEKEKLQLKEKADKAAEEIKLSQKQLSSLTETLKKVKLESEEKDKRVETAEAHVAALQKQAADLLLEYDRLLEDNQNLQNQAHGYRS
The following text describes a protein:
Function:
This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Possesses a wide variety of biological activities.
Subcellular Localization:
Lysosome. Cytoplasmic granule. Note=Matrix of eosinophil's large specific granule.
Sequence:
MVPKLFTSQICLLLLLGLMGVEGSLHAKPGQFTWAQWFEIQHINMTSGQCTNAMQVINNYQRRCKNQNTFLLTTFADVVHVCGNPSMPCPSNTSLNNCHHSGVQVPLIHCNLTTPSRRISNCRYTQTTANKYYIVACNNSDPVRDPPQYPVVPVHLDRII
The following text describes a protein:
Function:
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells. Shows high affinity for the receptor tyrosine kinase EPHB1/ELK. Can also bind EPHB2 and EPHB3. Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Membrane raft. Note=May recruit GRIP1 and GRIP2 to membrane raft domains; [Ephrin-B1 C-terminal fragment]: Cell membrane; Single-pass type I membrane protein; [Ephrin-B1 intracellular domain]: Nucleus. Note=Colocalizes with ZHX2 in the nucleus.
Sequence:
MARPGQRWLGKWLVAMVVWALCRLATPLAKNLEPVSWSSLNPKFLSGKGLVIYPKIGDKLDIICPRAEAGRPYEYYKLYLVRPEQAAACSTVLDPNVLVTCNRPEQEIRFTIKFQEFSPNYMGLEFKKHHDYYITSTSNGSLEGLENREGGVCRTRTMKIIMKVGQDPNAVTPEQLTTSRPSKEADNTVKMATQAPGSRGSLGDSDGKHETVNQEEKSGPGASGGSSGDPDGFFNSKVALFAAVGAGCVIFLLIIIFLTVLLLKLRKRHRKHTQQRAAALSLSTLASPKGGSGTAGTEPSDIIIPLRTTENNYCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
Subcellular Localization:
Cytoplasm.
Sequence:
MKPSIILYKTLPDDLLHRLEAHFTVTQVPNLHPETVAQHAQAFASAQGLLGASETVNRALLEKMPALRAASTISVGYDNVEVDALTARKIVLMHTPAVLTETVADTVMALMLATARRVVDVAERVKAGEWTESIGPAWFGVDVHHKTLGIVGMGRIGMALAQRAHFGFTMPVLYHARRRHQEAEDRFNARYCDLDTLLQEADFVCVILPLTAETRHLFGATQFARMKSSAIFINAGRGPVVDENALIAALQNGEIYAAGLDVFEQEPLSVDSPLLNMSNVVAVPHIGSATHETRYNMMACAVDNLIDALQGKIEKNCVNPQAAG
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSFEKLQKELHEAIEGVNRYNPENVADLAACVQAMVNENKYDKDIVLTILKLYQLNPEKYDEAVVRQVLLKTLMVLPSSDFALAKCLIDTNRLGSQELRRIFDLGAVLESCNFAVFWKLVKGAYKPTTNPNEPFKVPGEVPKMIKPMVGFEDAVKHYACRVISVTFQKIEKKMLSRLLGGASDKEVTALAQSFGWEAKENGDVFFVANHEGTIKTRNIDEKIQFPHVADLLTSIQPPLTL
The following text describes a protein:
Function:
Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.
Sequence:
MSSRTPSRLAFTQASDALATLVSPSAQFATADFDPALKDWSFVKPLVVGAGGIGCELLHLLALSGFAHLTVIDMDLIELSNLNRQFLFTHSDIGKAKSTTAAAAVQARCPGVSVTAVVGCLEDQPDDFYRSFDAVLLAVDSIPARRWINRKVAEIATRVIVPTPASASPPAARSAAPPEDAVAASAAQAPAAVYRIGNYVIEDAKLIIDTGTEGFEGHCRVIHMAHNRTPCIECEMYLYNNGATRETVPLCTLESVPRAPEHCVLYVQLKEWPEHHRHRSRRRSQGGDGDGAVAGGGCEEDSKDGDRDELLNPDNAEHVRWVTERARARQAAFGIGGAPIDDLFTVGVIKNVVPAVGFTNAYVAGQAVTELMKWLTGCAPELNNYAFYNGATEAGVHTNVEPCRGSPMHGSGDVAGRCLVCEPCPVVAADASAVSAVAFRDALIELLAPDATAAALLRRGIVLLVFQSASKLVEVPLPNAVKEAGAVKHESIASMLCAAGHEEFVKQWKDGARMATVECFGAADNARVSALVQWQGPPVWA
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MVNLSPDDLADMTERFDINKLNNEYGGPVNLCKSLNSDPQQGLNNNQALNQNLSSYGHNDLPVREIKTFCEIFLDAISDKTLIILIICAILSLILEVTFASPEERSTSWIDGGAILIAVAIVSIVQTISNSNQEKQFAAVNRIKSIFKVTVIRYGHTTQVQNLDIVVGDVVILEPGDKIPADGVILTSEDLYVDQSVASGESEAVLKSETDPFLIGGTHVSDGRGSFLVTSVGTRTQQGKALNAIANEESRETPLTEKLSVLAEQIGYLGMGFASLAFICILIPWIYHEIKLKQFSIARLREPLDMLVVSLTIVVCAVPEGLPLAVTISLAYSMRRMMTDNNFVRRLEACETMGSATVILTDKTGTLTKNEMNIERMIIAGSVTTNLPSKLREDKEFMSNLVDGLVVNSHAILDGASSIGNQTECALLRFSANALRIDWQNIRNNAKILHCFQFDRIRKLMSTIIQNGNDIVVHTKGAPDLLLPKCTKFYNDDGLIKEMTENNRNFFQQKVIEEGKQSFRTIALAYKKCPTKPLTANDAENDLILLAIFSIRDTIRPNTQRSISAVKNADIRVVMLTGDHPSTAAAIATDVGILENGYKIITGSELNGLKPSDVYEILKDVSVVARSTPLDKHMIVNAFKQAGEIVAVTGDGTNDVPALMAADVGLAMGKSGTELAKEASDICILDDDFRSIVRSVVWGRGISNNIRRFLQFQLTANVVTLIISTFDAIYSQTAPFKAVQLLWVNLIMDSLGALSLATGTPSDNLLNRPPIPPSSPLISFFMFYQISVQTIFQLLTMFVLSKIQKESETFVFTVFILSQAFNLFNCRAAEPNDSAFQGAFHGLFILIFLLICLIQIVLVEFTPKFFACEPLNLMQWICAFFDAAMAIPVGIIARYWFPKFRFLRSKSKK
The following text describes a protein:
Function:
Plays a role in maintaining the structural integrity of the 19S regulatory particle (RP), subcomplex of the 26S proteasome. Plays a major role in both the direct and indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP). Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a potential docking subunit for both ubiquitin receptors RAD23s and DSK2s. Plays a role in the growth and development via the proteasome-dependent degradation of the ABA-signaling protein ABI5/DPBF1. Plays an important role for balancing cell expansion with cell proliferation rates during shoot development.
Sequence:
MVLEATMICIDNSEWMRNGDYSPSRLQAQTEAVNLLCGAKTQSNPENTVGILTMAGKGVRVLTTPTSDLGKILACMHGLDVGGEINLTAAIQIAQLALKHRQNKNQRQRIIVFAGSPIKYEKKALEIVGKRLKKNSVSLDIVNFGEDDDEEKPQKLEALLTAVNNNDGSHIVHVPSGANALSDVLLSTPVFTGDEGASGYVSAAAAAAAAGGDFDFGVDPNIDPELALALRVSMEEERARQEAAAKKAADEAGQKDKDGDTASASQETVARTTDKNAEPMDEDSALLDQAIAMSVGDVNMSEAADEDQDLALALQMSMSGEESSEATGAGNNLLGNQAFISSVLSSLPGVDPNDPAVKELLASLPDESKRTEEEESSSKKGEDEKK
The following text describes a protein:
Function:
Homophilic binding protein that enables kin discrimination in heterogeneous yeast populations by mediating homotypic cell-cell interactions during flocculation, a reversible and asexual process in which cells adhere to form aggregates (flocs). Plays a role in cell-substrate adhesion, haploid invasive growth, diploid pseudohyphae formation and biofilm (flor) development. Adhesive activity is inhibited by mannose, but not by glucose, maltose, sucrose or galactose.
Miscellaneous:
MISCELLANEOUS: In the reference strain S288C, the transcriptional activator FLO8 contains an internal in-frame stop codon, leading to impaired FLO11 expression in this strain.
Subcellular Localization:
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=The protein is attached to the cell wall via a GPI-anchor and is also shed liberally into extracellular fluid; increased shedding is associated with biofilm mat expansion but decreased invasive growth.
Domain:
The number of the intragenic tandem repeats varies between different S.cerevisiae strains. There is a linear correlation between protein size and the extend of adhesion: the more repeats, the stronger the adhesion properties and the greater the fraction of flocculating cells (By similarity); The Flo11 domain contains aromatic residues that form two hydrophobic bands on the surface of the protein that confer homophilic binding. The hydrophobic bands are lined by stretches of acidic residues that may sensitise the protein to environmental pH. The domain is required for biofilm formation. The domain does not interact with mannose or calcium ions.
Sequence:
MQRPFLLAYLVLSLLFNSALGFPTALVPRGSSEGTSCNSIVNGCPNLDFNWHMDQQNIMQYTLDVTSVSWVQDNTYQITIHVKGKENIDLKYLWSLKIIGVTGPKGTVQLYGYNENTYLIDNPTDFTATFEVYATQDVNSCQVWMPNFQIQFEYLQGSAAQYASSWQWGTTSFDLSTGCNNYDNQGHSQTDFPGFYWNIDCDNNCGGTKSSTTTSSTSESSTTTSSTSESSTTTSSTSESSTTTSSTSESSTSSSTTAPATPTTTSCTKEKPTPPTTTSCTKEKPTPPHHDTTPCTKKKTTTSKTCTKKTTTPVPTPSSSTTESSSAPVPTPSSSTTESSSAPVTSSTTESSSAPVPTPSSSTTESSSAPVTSSTTESSSAPVTSSTTESSSAPVPTPSSSTTESSSAPVTSSTTESSSAPVTSSTTESSSAPVTSSTTESSSAPVTSSTTESSSAPVPTPSSSTTESSSAPVTSSTTESSSAPVPTPSSSTTESSSAPVTSSTTESSSAPVPTPSSSTTESSSAPAPTPSSSTTESSSAPVTSSTTESSSAPVPTPSSSTTESSSTPVTSSTTESSSAPVPTPSSSTTESSSAPVPTPSSSTTESSSAPAPTPSSSTTESSSAPVTSSTTESSSAPVPTPSSSTTESSSAPVPTPSSSTTESSSAPVPTPSSSTTESSSAPVTSSTTESSSAPVTSSTTESSSAPVPTPSSSTTESSSAPVPTPSSSTTESSSAPVPTPSSSTTESSSAPVTSSTTESSSAPVPTPSSSTTESSSAPVPTPSSSTTESSSAPVPTPSSSTTESSVAPVPTPSSSSNITSSAPSSTPFSSSTESSSVPVPTPSSSTTESSSAPVSSSTTESSVAPVPTPSSSSNITSSAPSSIPFSSTTESFSTGTTVTPSSSKYPGSQTETSVSSTTETTIVPTKTTTSVTTPSTTTITTTVCSTGTNSAGETTSGCSPKTVTTTVPTTTTTSVTTSSTTTITTTVCSTGTNSAGETTSGCSPKTITTTVPCSTSPSETASESTTTSPTTPVTTVVSTTVVTTEYSTSTKPGGEITTTFVTKNIPTTYLTTIAPTPSVTTVTNFTPTTITTTVCSTGTNSAGETTSGCSPKTVTTTVPCSTGTGEYTTEATTLVTTAVTTTVVTTESSTGTNSAGKTTTGYTTKSVPTTYVTTLAPSAPVTPATNAVPTTITTTECSAATNAAGETTSVCSAKTIVSSASAGENTAPSATTPVTTAIPTTVITTESSVGTNSAGETTTGYTTKSIPTTYITTLIPGSNGAKNYETVATATNPISIKTTSQLATTASASSVAPVVTSPSLTGPLQSASGSAVATYSVPSISSTYQGAANIKVLGNFMWLLLALPVVF
The following text describes a protein:
Function:
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.
Sequence:
MQLVYLQREKRTCFDEENNDIFYGFLVVEDSDNYLGGEVALDLHKTPNVTIRHALNNNTKLVKNLQIGKFPTLVIIDRNNNTQIVTENIEHKKELKATIADYLAKKGLKVCETTPEKKGHLSLDPHPDPKQRSRTLLRQKIKKMGDAVFQMDLETSLRYALLREVSTTKVIKGEQLAALRAFLSVIKKYFPFGYNSTSFINNLTNLTSSDEVQGVQVQVLVQQADDSGVFSTPQRFLGCQGSANRFRGYPCSLWRLFHYLTVNSVLLNVSNRKANPVEVLGAMHGYVKHFFSCSHCSEHFQKMAAERNLTSVSSLEESVLWLWEAHNVVNKRLKGDTTEDPEYPKEQFPTRLRCPECYGEDGTWRKKEVLKYLKRMYGRYSVRYVGSDTKVLFPGLDR
The following text describes a protein:
Function:
This protein is involved in processing of the 5' terminus and the intervening sequences of cytochrome b pre-mRNA.
Miscellaneous:
MISCELLANEOUS: Present with 2130 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MSSSQVVRDSAKKLVNLLEKYPKDRIHHLVSFRDVQIARFRRVAGLPNVDDKGKSIKEKKPSLDEIKSIINRTSGPLGLNKEMLTKIQNKMVDEKFTEESINEQIRALSTIMNNKFRNYYDIGDKLYKPAGNPQYYQRLINAVDGKKKESLFTAMRTVLFGK
The following text describes a protein:
Function:
Beta-glycosidase that catalyzes the transfer of glucose moiety to anthocyanidin 3-glucoside at the 5 position. Anthocyanins are ubiquitous colored pigments that are responsible for variations in petal color. Uses acyl-glucoses, but not UDP-glucose, as the glucose donor.
Subcellular Localization:
Vacuole.
Sequence:
MNMSCKFEIVLLVSWWLLLVLVFGVESSMFSEFDRLDFPKHFIFGASSCAYQVEGAAFEDGRTLSTFDIAAHSGHLPGNGDITSDEYHKYKEDVELMVETGLDAYRFSISWSRLIPNGRGPVNPKGLEYYNNLVNALLTKGTQPHVTLLHSDLPQALRDEYGGLFISPKFIDDFVAYADVCFREFGDRVLHWTTFNEANFLAFGDENTPASALYLSAHHLLLAHASATRLYRENYQASQRGFIGINVYAYDFIPETNTEVDVIAAKRARDFFIGWFVQPLMNGEYPLTMRKNGGPRLPKFTPNETELLTGSYDFIGLNYYTAKTVKDDPVMLTVEPRNYYTDQGLISSYLGNIDPYQGHPFFNTPWGLHDVLQQFKQVYGNPPVYIHENGEVGDHDADYDKLINDIPRVEYLQGHIRAVLDAVRNGSNVKGYFVWSFLDMYELMYGTKFTFGLYYIDFNDPKLTRHPKLSQKWYSRFLKGEKASTKASIHTPNEAETHTYFY
The following text describes a protein:
Function:
Catalyzes the reversible C-3 epimerization of several ketoses. Shows the highest enzymatic activity for the epimerization of L-ribulose to L-xylulose. Is also able to convert D-allulose (also known as D-psicose) to D-fructose and, to a lesser extent, L-tagatose to L-sorbose, D-ribulose to D-xylulose, L-allulose to L-fructose and D-tagatose to D-sorbose.
Sequence:
MKIGCHGLVWTGHFDAEGIRYSVQKTREAGFDLVEFPLMDPFSFDVQTAKSALAEHGLAASASLGLSDATDVSSEDPAVVKAGEELLNRAVDVLAELGATDFCGVIYSAMKKYMEPATAAGLANSKAAVGRVADRASDLGINVSLEVVNRYETNVLNTGRQALAYLEELNRPNLGIHLDTYHMNIEESDMFSPILDTAEALRYVHIGESHRGYLGTGSVDFDTFFKALGRIGYDGPVVFESFSSSVVAPDLSRMLGIWRNLWADNEELGAHANAFIRDKLTAIKTIELH
The following text describes a protein:
Function:
Involved in translation.
Subcellular Localization:
Cytoplasm.
Sequence:
MFKKFNLKEDIAGQTQVKSSVQRNFRAKIVEQFPLLAPYIDDLIPKKDPVFLVKCLDRVNIISVNNKFLFFNSFDGPFFPSLYILHKYPDILPKLQVDRGAIKFVLKAADIMCPGLTSPGGNLPSESLPAETVVAIYAQGKEHAVAVGMTKMATDDMKKINKGIGVSNAHYLNDGLWKTLH
The following text describes a protein:
Function:
FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Bacterial flagellum basal body.
Sequence:
MMDFEDFGNPLAGKPLSQADKAAAVLLAMGKGVAGKLLKFFTQHELQMIISSAQTLRVIPPDELAQIVAEFEDLFTEGTGLMDNAKAIESILEEGLTPEEVDSLLGRRAAFQAYEASIWDRLQEAEPEFVGKFLLREHPQTIAYILSMLPSSFGAKVLLTIPEEQRADIMNRTVNMKEVSPTAAQIIEKRVVNLINEIEAERNAGGSTKVADLMNELDKPQVDTLLSSLETLSKEAANKVKPKIFLFDDLMFMPQRSRVLLLNDVSADVLTMALRGATVEIKECVLSSISPRQRRMIESDLAVPQASLNTREVAIARRAVAQEAIRLANSGQIQLKDVAAEEQSAAA
The following text describes a protein:
Function:
Lignin degradation and detoxification of lignin-derived products.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MKFSIHLNGMYFAGGIYRQLFVLLFLVFCIHLSTNRVVRAGTSGITTRRYNFVVNYATFTRLNHTKRMIVVNGQFPGPAIRANEDDIVIVNVTNLVAAPVTIHWHGVKQIRTCWADGVPYITMCPLQQNQSFSHRFQLLNQTGTMWYHAHISWLRASVHGPIVLRPRKFESFPFTSPKREITIMIGEWWNNDVEDVLAYALARGGRYNISDAITLNGQPGFLYNHSSKDALKVKVTHGETYLLRVVNACLNFGMFFGVANHSLKVVQLDSAYVKPFTVNTVLIAPGQTLDALLTANRASGRYYMAASPYSVPDPQYVPFPEIPATARMEYEESSYEIERSSSEIVTYMPTFPSPNDSNYRHKFDDLQKSINTTYQTLDVPETVDKHLFFTVGYGLDKSSSCHPFKTCVDGYDGQYRVVGSVNNISFVTPNTTSKSLLEIAYLRDHGNASVTSALDLDFPSQPTMTFNYTGSTRLPLSQWFSKHATKLSVINYNASVQIILQNTNIVQFETHPFHLHGYSFYIVGRGNGNYDPDSSPATFNLVDPPLRNTFGVPHRGWLALRFRADNPDFGPPICDNLVRIYGTFPSLIDHFTTEQAKGQIYRKMNTNSNSSAGRVWLFHCHFEIHTSWGMETVLYVKEGTGTNQTLEAPPSDLPACASSENTSKKKEPTVSITISEDITKPEISKEVPH
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRASAMEDHHAPVPLSEATGTSRSYGTYTYDVHEFDRMRKEDLASSVRRRFTKRSHTVITGSENFGAGLQDSLEDIFARANEAVPMYEKLGKVEGIANTLHTSLKSGVDGNTVEARRVFFGKNALPEEPPLTFWEMYKASWEDRMIRLLAVAAIVSLILGLTVPDPGETEVNYTTGWIEGFAIICSVIIVTTVSSVNDYNKEKRFHKLTEENSAQPVRVRRGGKDVTIDVTEIVVGDIVSLSPGLVVPVDGFYVTGMSVVIDESSVTGENDPKKKSASAPIILTGTVVNTAEDAYMLACAVGERSFGGKLLMESRGAGTPRPTPLQERLDELADLIGRIGLGAAMLLFALLSLMEGFRMLQHDPGASYRHFLDYFLLCIAIIVVAVPEGLPLAVTIALAYSQNKMHDDNNQVRRLRACETMGNATQICSDKTGTLTQNLMSVVQGYVGMQHFSVKRPGDLPEPVPLSGMRAISLRQLSEGIAINSSSEKVVSTTDKEGHTAAPYWQWVADKGNKTDNALLDFVDRVAMTEADARDMGSRPHQRIREACRQRGFTIFPFTSDRKRMSAVVRQEDGTLVHHVKGGSDRILPLCDRYVNEAGDEVPMTDEARARIAQQVKKLADMANRTIGVAYAVLGGTELPEDEPTESLVWLSLLGIQDPLRPEVADAVMKCQAAGVTVRMCTGDNIDTAVAISRQCGIFNPYYGDLAMTGQDFRNLVYDAYGDEERMAKFWPVLDHMTVMARSQPLDKQLLVLMLMTRGEVVAVTGDGTNDAPALRLANVGFVMRSGTDIAVKSADIVLLDDNFRSVQRAVVWGRCVNDNIRKFLQLQLTVNYVSVALTFIGSLMAGGHSSPLTTVQLLWVNLIMDTLAALALATEEPSEECLKRQPIHRKAPLVSCRMHMTIFSVAAYMLVLTLSLQAYAHVWFKAVPLDGVEHSTIIFNVFVLCSVMHMLNCRKLYDELNVLEGICSRSALCISVISFCFLFQIIAVQAFGGFMKVTALRSEEWVVCVILATGVLFIGFVSRLIPVCEPQFEKTFDGSMLDEDAKAMLARLDSAVTKAQAATDEYKEGIYLERARRLRARALWSEARHHHLNVSRVVNAFRRRRAERIEEGSLLSVM
The following text describes a protein:
Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.
Subcellular Localization:
Nucleus.
Sequence:
MVRVKNRYLLVEILYPDPSSSPPLSSATSLKNYGQRSQLRFHAPTSDALTPSLLAKMVRDEVAKMFGDWGIGRLGGVGAGGVSVKYLSPATSTAIIRCPRASYRLVWTALTYISHVPDLSGTNGAKSKRLDLANLSRPCVFRVVRVSGTIKKAEEEAVRRARREIVRLRGKEELGVLDGLVGELERDIERGKGREKKVVEDVDDMELDVNSDVE
The following text describes a protein:
Function:
Involved in the biosynthesis of steroidal saponins and alkaloids natural products from cholesterol such as spirostane-type saponins and polyphyllins, compounds with pharmacological activity. Catalyzes the C-22 hydroxylation of cholesterol to form 22R-hydroxycholesterol.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MALELILVLSSLIVILIIFFSFKSNGKSENKLAKLPPGQMGWPFIGQTIPFMQPHSSASLGLFMDQNIAKYGRIFRTNLLAKPTIVSADPDFNRYILQNEGRLFENSCPTSIKEIMGPWSMLALAGDIHREMRSIAVNFMSNVKLRTYFLPDIEQQAIKVLASWENTPEAFSAQEQGKKFAFNLMVKHLMSMDPGMPETEKLRTEYHAFMKGMASIPLNLPGTAYRKALQSRSIILKIMGQKLDERIRQVRDGCEGLEQDDLLASVSKHPHLTKEQILDLILSMLFAGHETSSAAIALAIYFLDSCPKAAQQLREEHVEIARQKAERGETGLNWDDYKQMEFTHCVINETLRLGNIVKFLHRKTLKDVQFKGYDIPCGWEVVTIISAAHLDPSVYDEPQRYNPWRWQNISATASKNNSIMSFSGGPRLCPGAELAKLEMAVFLHHLVRKFHWELAEHDYPVSFPFLGFPKGLPIKVRPLEKSEA
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MGLWDALYRVVMRRNAVYVTFVVAGAFAGERAVDYGVHKVWEMNNIGKRYEDISVLGQRPAE
The following text describes a protein:
Function:
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
Sequence:
MSGFQMPQANFKAGFVRENFNKIAKKYDRFNDWNSFLLHRVWKNHLVREIENNFSGHLHVLDLCCGTGDISLRLENSSFVDHVTCVDFSENMLEIAKTRLKKQAQKGRVHFELGDATKLIQFQNSQFDVVSIGFGLRNVDNLSKAIGEIFRVLKPGGMFLNLDVGKVKNPWIRWIADFYFFKIVPILGYILWGGKNEMFDYLPVSSLSYPDQETLQLILEKEGFQRVQYKNFVFGNVVLHVAKKPSEKT
The following text describes a protein:
Function:
Cell surface glycoprotein that participates in iron homeostasis in the liver, the kidney, the retina and oligodendrocytes by acting as a receptor of H-ferritin. Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes. Plays also an important role in the regulation of Th2 immunity. Receptor for SEMA4A involved in the regulation of T-cell function, enhancing T-cell activation.
Miscellaneous:
MISCELLANEOUS: Belongs to the T-cell and airway phenotype regulator (Tapr) locus, a single chromosomal region that confers reduced T-helper type 2 responsiveness and protects against airway hyperactivity (AHR), the hallmark of human asthma. The human genomic locus appears to lack the Timd2 gene.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MNQIQVFISGLILLLPGAVESHTAVQGLAGHPVTLPCIYSTHLGGIVPMCWGLGECRHSYCIRSLIWTNGYTVTHQRNSLYQLKGNISEGNVSLTIENTVVGDGGPYCCVVEIPGAFHFVDYMLEVKPEISTSPPTRPTATGRPTTISTRSTHVPTSTRVSTSTSPTPAHTETYKPEATTFYPDQTTAEVTETLPDTPADWHNTVTSSDDPWDDNTEVIPPQKPQKNLNKGFYVGISIAALLILMLLSTMVITRYVVMKRKSESLSFVAFPISKIGASPKKVVERTRCEDQVYIIEDTPYPEEES
The following text describes a protein:
Function:
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.
Sequence:
MGFLGVYSAVYDYVPAGEGELTIKEGDILYVLEKSTEDDWWKAKKKASAEDEDEPVGLIPNNYIQEAAPSGKARALYDYTRQTDEELSFTEDAQLEVFDTSDPDWILVGFEGEYGFVPANYIELSEEEQHKEAPAPSLPSRPRPASVPVEEEAPAAPQSPLSPQPAETPVATPAAAIAGILKQRQASAPAARAPPEFTPEASDEEPPTPTLPARPVSQVSVPQPTRGQEHDREREPARRYSPRLPASPVVTASPPHNRVSFSTMGVVNDVDEHKAARAPGGFHMYNISEMVHVMGKKKKMPTTLGINIATGTILIAPEQARDGPEQTWTAEKMTHYSLEGKHVFMELVRPSKSIDFHAGAKDTATEIVSALGELAGAARAEGLREVIAAGSGSGQKRGQVLYDFVAQGDDEVDVNVGDEVVIIDDVKSEEWWMVRRVKNAKEGVVPSSYIEIMGAIQSASSAGINAGRSTVEQNRLEEARLAREALKTAKKDEVEVGPGMRLPERGSSLFARDNGNQSGEQKRRESVRESGQSRSSKSKPDPAKVRTWTDRSKSFSVEAQFLALKDGKINLHKMNGVKIAVPVVKMSVEDLEYVERMTGISLDEDKPLSDIKKQQKSRAAERDSSNGASPAPGPSASMGAGASIQTPEYDWFQFFLSCDVNVGLCERYAQAFKRDSMDESVLPDIDATVLRNLGIREGDIIKIIRFLDKKYMRKDGKRNVSFGGEDEGEAGLFSGPGGALKNNTRKGRPAPAVQTNDVVDANAFSQNGTEKSSPQGVATPLANAPTPAEKDVKREGFDDDAWDVKPSKQETTSSPPAQSIPAAAPQQPVITGSMQELSLLSTPLEPVKAQPTAQASPQPQAPPAVTPSIFAGIGNQQTGVPQPQPLPSGPLLPANLARQRPAPPQMTANSTLIPPLPPSRPLSAPQAASAYAPPPLQAQATGYGAFQPQIAPPGQSLHDLNQQRMQQQQQQQMQQQQFMLQQQQQAGMMQQPTGFNQFNPGVPNNFQQFPMQTGNPQQPFIPNQTGTPFANPPAQPFQPQPLQAQPTGFQSAFPPGQQYPQPTGVNSYLPPALQPQPTGMMNGANGFNQNFTPPPIPPMPQQQPAPMLPQATGPAPPVRFGVNGTNNIAPQPTGRRANLAQATPQNPFGF
The following text describes a protein:
Function:
Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (Probable).
Subcellular Localization:
Nucleus.
Sequence:
MSAYHVGQLVDKMSNPDKDFRFMACNDLMKDLQTGTIALEDDSTAKVIRALIKLLSDSNGEVQNLAIKCIGLLAQPSKIKTHHLEYLVEELTPHVFSKAEQSRDIHSLTLKAMILNLAPSASSNATTTVVKRMLPKFVDSLSLCAPDDAARVDVLDLIGEVLLRFGDVVPEMHKGSLKVMVDHLYSFRSAIRKKAITGIGHLASVINGELYDELVQDLLKELAQRSPPSSAAQNVQLRTLVIALSTVARASGSRFSKHTPKVVPFLLQYLQIDPGTESEHDDLREASIQGLEVFLYRNPQEVVAFEKEVIQQLTDALAYDPNYEYGDDDEDEQMEDDEDDDEDEYSDDEDVTWKVRRAAAKAIEAMISSHRESLLNLSQKIGPVVIGRFKEREETVRTEIISVYIALLNQISILVPDLQKAVVAADEDSIETDDIVVIGGTKFSTNYLSRSQLAIIQSLADQKDVLLRTITKSMKKHPKTGPKCIELLSALIRTYPSGLEDSLDDIIPAVSNILTDKNASAQGKMTVLSFISNALTLNNPKRFKNLLSPLTTIMTHSISEPFYKVSAEGLAVCCKYIDVLRELSACGGNEEAKKLLVVVEKKFMANDTDQEVRERAISAISMLLAAFKDVLKNETPAILEKMTERIGRDMTCLVAFRASTHIVEAGIIFSSAQLQSILRHVVDYVKKIARSLRMTCLNFVEKLMKHSPAGSIPVEELTCVLGEMSNLISETDLQITNQAFCCLTYAFLNFPTCVSLHMQPILDSIIRLLTSPLIQGLALNSLLNLFTAIVKTDFPEKPTFESLLDSVTSPVYDNVALSRHAHMAIASCAAVITESTQNLEKSRSLAKKLAQQLQTANMSDSIRLFAMITLGELGRRVPDTYSPDFPVKPEDLAIKAFNHHHEDLKSAAAQALGALAVGNLNVYLPFILEQIRTQPKKQYLLLHALKEVIVWESSSEESTKSTDLFRSAIVDIWGMLMANAGGNEDGTRSVVAECLGRLCSFDPESLLPKLKESMRSSDPAIRSSAVSAIKYMINDEKRIVDITLQKQIGDFLAAVRDEDLKVRRVALVVLNSAAHNKPALVRDLLPDLLPAVYEETKLRKELIKEVEMGPFKHQVDEGLDLRKCAFECMFTLLESCVDKIDITQFSSVMEVGLSDQNHDVKLLNYLTLQRVANLAPGQVLQRIDRVCEPLKTQLNVRPRGNAVKQEVEKLEELKKAVIRVVYGLKLKLPEVERNPQFLDLYNTIKHTKELEALANDVLKESQRAVVYDTPMETA