lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that acts as a negative regulator of the response to water stress. Mediates ubiquitination and subsequent proteasomal degradation of the drought-induced transcriptional activator DREB2A. Functionally redundant with DRIP1.
Sequence:
MEGDMVAKVKRETVVACMTCPLCDKLLRDATTISECLHTFCRKCIYEKITEDEIESCPVCDIDLGGTPLEKLRPDHILQDLRAKLFPLKRKKERAPEVVSSISLPAKRKERSISSLVVSTPRVSAQAGTTGKRTKAATRKDVRGSGSFTKRTVKKEEEFGDDHVESASSPETLKKFTQNKRQSSYANPNQSLSNRRNKDVDEPWDSKLHLWKPLNFLVDVANGTKDPKSELGNASHNDVQGSKTKTKDHKRKCKLEEEISNNGDPTTSETATLKRTRRTRRKRSSTFGDSRIPLLPGAASLKQERRNGHVWFSLVASSNQEGEASLPQIPANYLRIRDGNIPVSFIQKYLMRKLDLKSEDEVEITCMGEPVIPTLQLHSLVDLWLETTSKHQRVAASIGSSAKEFVMVLVYSRKLPECNN
The following text describes a protein:
Function:
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation.
Subcellular Localization:
Nucleus.
Sequence:
MSSGSSEVDVIRTRIPAYDDDNTVLYAYEPNTAYFSNQETAVSDTSFNEEQQAVIQDILVYCQAIYDAIQDLDKKFDIIHGKVSKIHRSRCRVKSTWQSRKLHGNRHKNNHQHSRKSKSHKRKRRDCPSSLSLTESYSPTIPTSRRDDDSQSNTLGTSIESHKSPEREQESFFQDQEPDLNQSPTVFTQSYEPYEYMQKEPMQGPSYCSSPRAHNFFPLDQATITPPAAILPDMGPEPIPPPDVVTYPPLFDPQPSRQSISPPYTPSAYAPTSPVRNNPDFFRENLPEDPSIWSVDEVTMFLQDVDPQTFDPLVDLFRDHGIDGKALLLLRSDMMIKYMGLKVGTALKICHYIDRLKRERYIPN
The following text describes a protein:
Function:
Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme (By similarity).
Sequence:
MSFDGFTDATEAQVTRAISDSWMEEFRERTDTEVIVVGGGPSGLVAAKELAERGVDVTIVEKNNYLGGGFWLGGFLMNKVTVRDPAQRVLDELGVPYEESDEAEGLYVADGPHACSALIKAACDAGAKIQNMTEFTDVVLREDDRVGGIVMNWTPVHALPRELTCVDPIAVESDLVLDATGHDAVVLSKLSERGVLDVNGIEHAKEHNTGMDKTADGEYGAPGHDSPGHDSMWVSESEDSIVDATGVVHPGVVASGMAVATAHHLPRMGPTFGAMLLSGRQAAQSCLDELGRDAPDVSISGPAPADD
The following text describes a protein:
Function:
tRNA (uracil-O(2)-)-methyltransferase, which catalyzes the formation of O(2)-methyluracil at position 44 (Um44) in tRNA(Ser).
Miscellaneous:
MISCELLANEOUS: Present with 7720 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MTGDGSAHISKNNQNQHKDRFKFIVNDKSILGPQWLSLYQTDGKVTFAKSHFEQAMMNVIREPNINSTVILRADILKEINHAAEAGSEPKFDESVLKKFEIDNGNESGEEDVKKINIEDLNIRSCETSESLKLSPVHEFVRRIIPRNFYKDAIINQTCLILNSKDPNFQETSLIVYTPHINSEKDCPFYIPRTQSVGILLHQSVLSVHYIPFPEDKTAFTDESERVVRTAYRLLQTANKHSKGVMQGYEKRVNHDQVVNKVNFQNTYIVLKKKYSKFLVENWAESTDPKKHVFEDIAIAAFLIELWIKVYGPDFRSKMQFRDLGCGNGALCYILLSESIKGLGIDARKRKSWSIYPPEVQSSLKEQVIIPSILLRPHPALKRQVPHLEHNGRFFPVKVTHEVIAPATVVYSSEDLLKSPQVNTAEFPPDTFIIGNHSDELTCWIPLLGHPYMVIPCCSHNFSGQRVRFNVRKRSPRSNEIKNQNNSKSTYSGLVDHVEYISSRVGWKVEKEMLRIPSTRNAAIIGVENATLKHFPTQAVYDMIWEDGGAEGWIQNTMSLLKRNPRNH
The following text describes a protein:
Function:
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.
Sequence:
MIDLSKTVFYTSIDIGSRYIKGLVLGKRDQEWEALAFSSVKSRGLDEGEIKDAIAFKESVNTLLKELEEQLQKSLRSDFVISFSSVSFEREDTVIERDFGEEKRSITLDILSEMQSEALEKLKENGKTPLHIFSKRYLLDDERIVFNPLDMKASKIAIEYTSIVVPLKVYEMFYNFLQDTVKSPFQLKSSLVSTAEGVLTTPEKDRGVVVVNLGYNFTGLIAYKNGVPIKISYVPVGMKHVIKDVSAVLDTSFEESERLIITHGNAVYNDLKEEEIQYRGLDGNTIKTTTAKKLSVIIHARLREIMSKSKKFFREVEAKIVEEGEIGIPGGVVLTGGGAKIPRINELATEVFKSPVRTGCYANSDRPSIINADEVANDPSFAAAFGNVFAVSENPYEETPVKSENPLKKIFRLFKELME
The following text describes a protein:
Function:
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of the mycotoxins phomacins, leucine-derived cytochalasans with potent actin polymerization-inhibitory activities and monocot-specific antigerminative activities. The first step in the pathway is catalyzed by the hybrid PKS-NRPS phmA, assisted by the enoyl reductase phmE, that are responsible for fusion of the leucine precursor and the polyketide backbone to produce a 2-pyrrolidone intermediate. The polyketide synthase module (PKS) of phmA is responsible for the synthesis of the polyketide backbone and the downstream nonribosomal peptide synthetase (NRPS) amidates the carboxyl end of the polyketide with the leucine precursor. Because phmA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase phmE. Reduction by the hydrolyase phmG, followed by dehydration and intra-molecular Diels-Alder cyclization by the Diels-Alderase phmD then yield the required isoindolone-fused macrocycle (Probable). A number of oxidative steps catalyzed by the tailoring cytochrome P450 monooxygenase phmB, the FAD-linked oxidoreductase phmC and the short-chain dehydrogenase/reductase phmF, are further required to afford the final products, phomacin D and phomacin E.
Sequence:
MLSSILLTIFCAFLSSTGAANVADWNSLNKTLKGQLKGATPLASPCFSQVNAYEETQSEDCATAIGQQCLLDSSDPSSIKAYANVSCNQGSVPSYYIQVKSAEEVKKAFAFAARTQTAISIKNSGHDYNGRSSGAGSLSLWTRKLQELKYEPSFVPQQCGRQAGVAAITTGAGINFDQVYTFAHEKGVTYLGGSGPTVGASGGWVMTGGHGVLSRVYGLGVDRVLEFEVVTTDGVTRIANACQNQDLFWALRGGGGGTFGVILSTTTRVEPKLSIAVAFIALPANTSQQVLAEWTSLAINSTIKWAADGWGGFQGSGITLLGTPLLSLAQAESSMAELAQFAKRNGGSVAVELLSDFYDMYTKYYITNVQAGGSALFSHNWMIPSRAYANAQGRKQLQDHMDWMSSVGLNPGFLATTPYVYSGVAKQCGTFDAFGWMGL
The following text describes a protein:
Function:
Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
Sequence:
MAKPLTDQEKRKQISIRGIVGVENVAELKKGFNRHLHFTLVKDRNVATVRDYYFALAHTVRDHLVGRWIRTQQYYYEKDPKRTYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDIEELEEMEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIKDGWQIEEADDWLRHGNPWEKARPEFMLPVHFYGRVESTKTGPRWVDTQVVLAMPYDTPVPGYMNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAASLQDIIRRFKASKLGCRDSVRTAFDSFPDKVAIQLNDTHPALGIPELMRIFLDIEKLPWDKAWEITKKTFAYTNHTVLPEALERWPVDLVEKLLPRHLQIIYEINQKHLDKISSLFPEDLGRIRRMSLIEEDGVKRINMAHLCIVGSHAVNGVAKIHSDIVKNEVFKDFSELEPNKFQNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTQLKKFVDDNSFIRDISKAKEENKLKFAQFLEKEYRMKINPASMFDVHVKRIHEYKRQLLNCLHIITMYNRIKANPSKNFVPRTVIIGGKAAPGYHMAKMIIKLITSVGDIVNNDPAVGNKLKVLYLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENIFIFGMRVEDVAELDKKGYNAQEYYEKLPELKKVIDQIKSGFFSPAKPDLFKEIVNMLFNHDRFKVFADYEAYIKCQEKVSDLYKTPKEWTKMVIKNIAASGKFSSDRTIKEYALDIWGVEPSDLKIPPPNEPRDVADDAGAAGKAKA
The following text describes a protein:
Function:
Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.
Sequence:
MSYFERLNYLNSFINYEKRLDNITYEEKKFYLERMRYLLKLMGNPQDNLQAFHVAGTKGKGSTSAMIFSILKEAGYKVGLYTSPHLQSIRERISTHKGFISQEEFIDLIDYAKPYIEEAKKHPIFGPPTFFEVLTALAFLYFYIKKLDYVVIEVGLGGRLDATNVINPLVSIITPIGFDHMHILGNTIEKIAFEKAGIIKEGKFVISSIQKEEAEKVIAKVAKERNAIYYKIDNLFKWERKDFSLNGQRFLLSGKDINEEFFIPLLGEHQIVNAITAFGAIYLLRDKLSIDYETVREGFKKVQWMGRFQIVSKSPLTIIDGAHNVESAIALRDTLKNYVNFNRLFLICGLMKDKDAEGFLKILNPLVYSYNFVPLSSHRTRSPEELGNIVKSFNADANINLHTNFYEAINFVKKEASPEDLILITGSLYLAGEALNYFYGNLD
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex.
Sequence:
MAGPVSPQTCKKKLYTISWERTLYNPFVRKLVNESCGAFTSLQIKAGTDGQISSSELIKSSHQYRCIMNACIEDLNQAADLANSVESNQALQEMSEIFYKAELVWNLCEILYLENPLGILPHLLEWIRIHFPNAVEETGTVLASPNPGLHESYWKALYGLVFQLRLESATKLLRIHPDFQSEAFQSAYELLKKMPVFSANSTVSAPEFTFRWNHWKEECESRTQAGDFFESKDLELLLEILCGKEEAFEKVGDHFETWYQRMITQLTFTQPTIGTLSLGDEAEQFFASLIGLDDLTSLDATLLAVLRRDTRKVIGEMQGVLDNSWFTAHLADLLYHAGALQSFEDINSLQLRETLLRDYSICLFSHQSLWSVGVLYLDHCPNVGSATLEHLLTRLPCQSEMKATKIISLAERRKLTSVVTSVCRVMGRRALANRRLGAAVAWAVKAQDAPLATYAADAVLKSYLQDSDFTSTDLLDSLGAGLLASDRLAFLGKYREFHRLYNSNDFHSAAGLLISLISSRIAPKYFWTVLLMDALPLLETNPPVFTSEQTYELMQSLQELTSSFQDDAEINPHPNCQLNSDKTMLITLALSRNLAKCFVQQTVCD
The following text describes a protein:
Function:
Ammonium transporter probably involved in ammonium uptake from the soil. Contributes with AMT1-1 to the overall ammonium uptake capacity in roots under nitrogen-deficiency conditions.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSGAITCSAADLATLLGPNATAAADYICGQLGTVNNKFTDAAFAIDNTYLLFSAYLVFAMQLGFAMLCAGSVRAKNTMNIMLTNVLDAAAGGLFYYLFGYAFAFGGSSEGFIGRHNFALRDFPTPTADYSFFLYQWAFAIAAAGITSGSIAERTQFVAYLIYSSFLTGFVYPVVSHWFWSPDGWASPFRSADDRLFSTGAIDFAGSGVVHMVGGIAGLWGALIEGPRRGRFEKGGRAIALRGHSASLVVLGTFLLWFGWYGFNPGSFTKILVPYNSGSNYGQWSGIGRTAVNTTLSGCTAALTTLFGKRLLSGHWNVTDVCNGLLGGFAAITAGCSVVEPWAAIVCGFMASVVLIGCNKLAELVQYDDPLEAAQLHGGCGAWGLIFVGLFAKEKYLNEVYGATPGRPYGLFMGGGGKLLGAQLVQILVIVGWVSATMGTLFFILKRLNLLRISEQHEMQGMDMTRHGGFAYIYHDNDDESHRVDPGSPFPRSATPPRV
The following text describes a protein:
Function:
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MRFLQLCLLLLLSYIHKGTALTCSDRKYLKDGECCSLCSPGKRMSQECDTDSETVCENCRNGEFQDKWNRESTCHQHAYCDPNAGKEQVTEGTTERNVECQCQNGRHCSGPTCEICLQNTPCSPGYGVTQKATNTSDTQCSPCAEGSFSNTTSYKDPCIIWKSCENEEEELLPGNSTRDKVCRMKSHRNHILIIVGILIFVTSLIIAATYLLRNKCRIFQTKKEKQQVPQMNGHKLVPTEDNDPEAGPIEDCYPLADTSAQGHPVAQEVGKDSHMSQEER
The following text describes a protein:
Function:
Binds to membranes enriched in phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Required for endocytosis and localization of actin.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein. Note=Localizes in a punctate pattern. Colocalizes with F-actin.
Sequence:
MKAAVRSVKNFSKGYTDTQIKVRNATTNDSWGPSGTAMAEIAELTYDQNEMLEVMDIIDRRLNDKGKNWRHVFKSLSLLEYCLHNGSENVVRWAKDNIYIITTLREFVYVDDNGHDQGQNVRTKAKEITSLLEDEHALKEARGDSRERDRDRDRTRSSRFDDDDDDRAPYEESRLSRAPSRASRYDDDDRDHRSRRRSRSRRPGRSRSRRRSRRPSPSAEHNSAEENDPELQRVIEESKRQAEEDAKRRNMANDSEAELQKAIQLSKEEDEARQRHQREREQQEQAFMGNQQNAYQPVDFFGNPVQPQPTGFLQQQPTGFIRPQNTGFVQPQYTGFVQPQHTGFVQPQATGFMQPQRTGFVQPQATGFVQPQATGFVQPQATGFMQPQRTGFVQPQATGFMQPQRTGFVQPQATGFMQPQRTGFVQPQATGFIQPQRTGFVQPQQNGFFNPQPTGYMQPQRTGMMQPQRTGFSQPFESNNPFPVMQPQRTGFGQTPNAPMMAPNHTGYVHPQPTGLQRQTTGYTGNNNPYSRPLQSQSTGILQQQQQQSAPRLEPTKTGSNNPFAQFSNLPSQSTAPATKPMKPVRTGDDRFSNIAQAISTGNPMGTDSFGNIGLTRVPTQHTGSKFTNSAGQTIQAQATGNTHNPFQSQQATGYYKQPMQQQQNMQQPYYNQQNYNYQNQQPMQGMQQQSMQPQVGSLIDL
The following text describes a protein:
Function:
Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
KYDHDAFLGEDQAAEFDELTPKQTKQRLRELFPKIDVDQDQKISLKELVEWIDVNMKKHTRKSSESRMEQMDKNKDGKVSWEEYVNVEYDPKNEKGMSNENKDHLKEMKKRDEKRWKHADMDNDNLLTIDELQMFIHPEETPRMTSVLVQENMEMLDSDKDGKISFAEYAGKLSVMWRMREDNQDSLKSLKDDFNNDLDKDKDGSLNKEELKSWIFPSGSPSSGEAEHLMTEVDKNKDNFLTVDEIMERYELFAGSRATNYGNMLKKEL
The following text describes a protein:
Function:
3'-5' exonuclease.
Sequence:
MKTIGNRYVVVDLEATSTGSKAKIIQVGIVVIEDGEIVDHYTTDVNPHEPLDAHIKELTGLTDQRLAQAPDFSQVARKIFDLVEDGIFVAHNVQFDANLLAENLFFEGYELRNPRVDTVELAQVFFPELEKYSLPILCRELGIPLKHAHTALSDAQATAELLLFLREKMAQLPKGLLERLLEMADALLYESYLVIEETYRNQSILSSPDLVQVQGLYFKKTEASLEPRKLSQDFSKNISLLNLEVREEQESFAKEVGLLLKDEPVSLIQAPTGIGKTYGYLLPALSQSKERQIVLSVPTKILQNQIMEEEGKRLKEVFHTDIHSLKGPQNYLKLDAFYHSLQENDENRLFRRFKMQVLVWLTETETGDLDEIGQLYRYQHFLADLRHNGNLSSQSLFVTEDFWKRSQERAETCKLLVTNHAYLVTRLEDNPEFVSDRLLIIDEVQKILLALENLLQETYDIQSIIDLIDKALVGEENRVQQRILESIRFECLYLIEQFQSGKSRKNILDSLDNLHQYFSELEVEGFDELVRYFTAEGDYWLEVTETSQKKIQISSTKSGRTLLSSLLPESCQVLGVSATLEISQRVSLADLLGYPEAKFVKIESRGKQEQEVVMVKDFPLVTETSLEVYAREVAALLVEIQAFQQPILVLFTAKDMLLAVSDLLTVSHLAQYKNGDVHQLKKRFEKGEQQILLGAASFWEGVDFSSHPFVIQVVPRLPFQNPQEPLTKKINQELNQEGKNAFYDYQLPMAIIRLKQALGRSMRREYQRSLTLILDRRIIGKRYGKQIVASLAEEATVKTISRSEVDEAIDRFFNEL
The following text describes a protein:
Function:
Damages membranes of susceptible bacteria. Has no hemolytic activity. Not toxic to mice. Does not inhibit the proteinases elastase and cathepsin G.
Subcellular Localization:
Secreted.
Sequence:
NEKSGSCPDMSMPIPPLGICKTLCNSDSGCPNVQKCCKNGCGFMTCTTPVP
The following text describes a protein:
Function:
Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus. Cytoplasm, cytoskeleton, spindle.
Sequence:
MPKTLTESEVEATFAKLKAADPDRKVDIIQFFGLQLEDVEELPASVIDPFLLILPPLIRSPHSLLLSSVLSSFLPYFLPLIPKHPTTHLRLALLQVLPALLEKLNDAKERIHSAAGNAIVILGELSWEAEPPIPASNLNSSGSLKAGSLSSSTATKSKPHETLPHLWERHLKDVLQGKAWRSKVEGMKVLTKMRSKEGAKMGLKAWLGVLVDLLEDGDGNVRDQARETVVELLSPPSTPPAARSEFKRLLVARNVRKTIADDIITRILSGEGSDRSTPAVMNSELGKEEGASRSGAAAPAHSQADDVDIVYVASPQDLEREFHSMLPFFEGKETEENWAPRERSIVRIRGMMKGQAHVKYQAAFIAGLKGGIVEGMSKTVLSLRTTVAQQSCYLLKELPEGLGAAFDNFVEFLLPILGKMSGFTKKLIADRSQTAVTSIITHTTVHPRIFINHISSGIQEKNVQIRAYSVNHLKTFLIVHASHAKHQIEATPGLSDTLDAAFRKALADVNPGVREVTRQAFWRYHEVWRSKAEVLMNSLDGQARKQLEKANPRTAASPMPSYASSSSTGAPSSANTKPPSKKMDLKAMLAERRRAVKEAGKQAQETNAGSPRVVSNPVFASPGVQHASITGLPRSSSAVGIARHVETSSPSPVRSPTPSSSATRIRPSPSPERIQSPIQTKIEIDSPLRSRYTSLTPDLARSPPKSPSPSLSPSLGLGESPLRQVLTYPAANGRHSVGEGKRAIPELVEVADNGAEHEVDELTLKEGQKTRDDGNTDQELPPTVQEEVDQVEQSQQFESEPRLEHPEPQQGNTFSTSTSGRVPSTPARSIATGTTASLPNSRNGNIKGEKIISSRLNPEAFQTPLNPKTSALRSSSAIRTPAWKDSPRPEAVTPQMMQKLKERRHERSWWVKRQELLEKASPLKPLTPSPSFAILPDIEALELGAPTLKNLQKIALFCSSHPVRPEPTAEQDEEEKRAFEEEKRVWTGLFDRVMNGVVDFLRPDKDKELLEQGLVVLWEIVQHQWPLVDDTQRLCHGLFRLRESSDAVVLESTNALISLLVQISDPMLLLCNLRSSLDRFLTKHPAPPSSSADNSDPMTSALSQLSLSSSKESPEKRTRNSGYLFGLTSIGMCVLRLSAPVIVSEGPKLGQIVMEAINDPSSIIRQAAHSLLLAIQCVTHDSRKTLAFVPAMSQGQKDLAVYYMAQNGVLEQIGLHKKATSEGEKGREGDRDNMTGELAGLMSRGVIRE
The following text describes a protein:
Function:
Required for wild-type expression of ArfA and ammonia secretion, not however part of an ammonia transporter. Is highly immunogenic and may play a role in virulence.
Miscellaneous:
MISCELLANEOUS: Expression in M.smegmatis leads to reduced survival capacity of human macrophage-like THP-1 cells and increase of the release of nitrogen monoxide (NO), and increase of the release of lactate dehydrogenase (LDH) and NO from mouse bone marrow macrophage line ANA-1 cells.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MEHVHWWLAGLAFTLGMVLTSTLMVRPVEHQVLVKKSVRGSSAKSKPPTARKPAVKSGTKREESPTAKTKVATESAAEQIPVAGEPAAEPIPVAGEPAARIPVVPYAPYGPGSARAGADGSGPQGWLVKGRSDTRLYYTPEDPTYDPTVAQVWFQDEESAARAFFTPWRKSTRRT
The following text describes a protein:
Function:
Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.
Sequence:
MMSEVELLRKFLRRGLNLTPEALSCLMRMDDVERIVELLPRKPVIDYEDILPLMRAESDEKIEFDVILKPDNLGISGNVEEFIRFIRARFDKLRPLVARWVDLEPIPIAELRNKTTRNGDNLFIIGMIMEKISAKDGSIRMVIEDESGTVNVVFRRDSRAWELAERTPLDSVIGVRGTYVNGKLYGESILLPDVKSDEVSEGRHEGRAVMISDVHVGSRYFNEWAFEKFVRWLRSEDARDVRYLIICGDLVDGIGVYPNQEEELRISDVYKQFEYAGRFLSRIPSGIKVIYIPGNHEPVRQAEPQPELQSDYLDILLDANHNIVALPNPSMVKIGSLSILLYHGRSLNAVMKHIPGLQPVNPQTVVEAMSWILRLRNLVPIYGEHPISPEERDWLLIENPPNLFHTGHVHVYGVGDYRGVKLVNSGTFENETPYIRSLGIEVTVGKVPVLNLENLEIKIMDFQ
The following text describes a protein:
Function:
Positively regulates the expression of the NorB efflux pump and negatively regulates the expression of the AbcA efflux pump. Binds specifically to the promoters of norA, norB and norC and abcA genes. Overexpression of norG leads to an increase in the level of resistance to quinolones, associated with a threefold increase in norB transcripts. Disruption of norG leads to an increase in the level of resistance to methicillin, cefotaxime, penicillin G, and nafcillin, associated with a threefold increase in abcA transcripts. Could also have an aminotransferase activity.
Sequence:
MKIPSHRQLAIQYNVNRVTIIKSIELLEAEGFIYTKVGSGTYVNDYLNEAHITNKWSEMMLWSSQQRSQYTVQLINKIETDDSYIHISKGELGISLMPHIQLKKAMSNTASHIEDLSFGYNNGYGYIKLRDIIVERMSKQGINVGRENVMITSGALHAIQLLSIGFLGQDAIIISNTPSYIHSTNVFEQLNFRHIDVPYNQINEIDTIIDRFINFKNKAIYIEPRFNNPTGRSLTNEQKKNIITYSERHNIPIIEDDIFRDIFFSDPTPSIKTYDKLGKVIHISSFSKTIAPAIRIGWIVASEKIIEQLADVRMQIDYGSSILSQMVVYEMLKNKSYDKHLVKLRYVLKDKRDFMLNILNNLFKDIAHWEVPSGGYFVWLVFKIDIDIKYLFYELLSKEKILINPGYIYGSKEKSIRLSFAFESNENIKHALYKIYTYVKKV
The following text describes a protein:
Function:
Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway. As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
Sequence:
MEKVNNQDASLQEEPPKPRQQTDIRGAVSLVSSRGFEQKGIFIISVFLFAFFSVLLAQSILTKSTVFVQIAFIQLLHFALYAIILLTDYYTTLPPDECHTYGYARSMIVCCFSVSLTVILFACSLLLDSLKEFLSSVAPDASLSVEHPSFSPVMPNIFALIAYGISALLLSQYRSNPSQSKYPHFHAAFLVAISGILHSLSKLVTAFLPFPSVPEHVSEQAIPLLNGLIALFIIDRARELLVPSFFVLMQATPEKLLEITDYSISETFIDKMVREVSHFEGVLDCKAPHFWGLTFTDYVGSLHIRAKNDANEQHIIQQAHAKFDPIVGHFTAQVDKDHWDTTVRDN
The following text describes a protein:
Function:
Catalyzes the conversion of chorismate to isochorismate.
Sequence:
MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFFNYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFHIYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTVNRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQIKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPERLIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSSCSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVDVIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPISEYEETQIKLKPMISALGGERR
The following text describes a protein:
Function:
Component of intercellular bridges during meiosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells. Not required for fertility (By similarity).
Subcellular Localization:
Cytoplasm. Note=Detected in the intercellular bridges.
Sequence:
MWYPPAAVVPFFESHSVTYEDRSAIAKWHFLPFDQRAVNEMTVLLNFLHISQGFHNETLYTDVRRRCMLMRSLFELVFANNYLELTNPKLLGWFLYLTAEDRTLIQNEGGLLSFLKKHPELGVTRQYVYVKAKPKGNYVPPPTTMASNDSRYPTFYGSSGCQNCGTSCPFGTKKCTRCGVHIVISQDKISVSENEKQLQLLPNSLKEELNVFQTSQSNVEMQNIHLGCTQSTLNTRSKQRSPEAHPHFYSKGMCSHAQCLSQLWQEVESREDAKHFKDTSAQASFCLDMELDVQSQVQRNDNTQNNQNQSYNPTEENDHNVDQETMPEYYSFSSISLDHTAWSNGSQSAETGFNDSITATKGSTELSDELSEAANSTAANSTDCFSCVSNSFELAEESGDCLDSRYEQQINKSNVGSSPKSKSSASVYVDQMIDACGDFRAFFTSTCATKTDQTFQVKNVATDTDLPAVSHEKDTQTMRMTTSDKNTITEVYMSDLDVLTEEFIKLKETEKGLKQMKSMNARRLCGCDCAQRVRKAELNLLALQFVMCQQHCWRRYFTSPLGESAYQGTEALPDSIAETLKTLQKDYHEMRQQILAGTPLDDLAPLSVNSEKISTGTNYSPSSVLAAHLDCAGSTIASDHKVDEEHTAMKVPPSEVCQDIETAPDEAKNECSKRDKALFILPKQTRISTEPKTVGANKDLNGSEAWFDAEEELGFPNQDGNMEKPNKMRETMRHKMETKGTDEDVSKQSSLLCITCLPGNITEHEVLLWFEKYNPTNVCISAFSNNTRAAIVYLKSYIDAKAAVEDLNGRSLQGHAVQVVHLSGTVSADLKPSDLSHSASESHKEDTAGDELRTKNLTYGSSHGGPRCSLERLTNVCNSPTASGTCVPQHYATMGSFDTIMARLSERHPNVARQRIVDALLELRAKHQGFLSGLPLRSIVDMTSELLTQTSSSARV
The following text describes a protein:
Function:
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MRILIGSLYFYFISFLFSKVNGFLTQRTSPVSSFPFYNYSYLNLSSVSQAQAPKTARALNFSYNAIEKITKRDFEGFHVLEVLDLSHNHIKDIEPGAFENLLSLVSVDLSFNDKNLLVSGLAPHLKLIPTSGASGPSQIYMYFQKSAEAALEPSAPAELLPHLEDPPNPGNVNPRFRQRRTEENKTSPPAATLRPDLCGAPINGLLDLSRTKLSNEELTAKLDADLCQAQLGTVLEFNISHSDLEMDLLSLFILFLPMKDIQSVDASYNRITINNIDVEAICHFPFSNFSFLNISNNPINSLETVCLPASITVIDLSFTNISTIPANFAKKLSKLERMYVQGNQLIYTVRPENPSATPRPPPGTVQISAISLVRNQAGTPIESLPESVKHLKVSNCSIVELPEWFANRMQELLFLDLSSNRISMLPDLPISLQQLDISNSDIKIIPPRFKSLSNVTVFNIQNNKLTEMHPEYFPSTLTTCDISKNKLKVLSLTKALENLESLNVSGNLITRLEPACQLPSLTNLDSSHNLISELPDHLGQSLLMLKHFNLSGNKISFLQRGSLPASLEELDISDNAITTIVQDTFGQLTSLSVLTVQGKHFFCNCDLYWFVNIYIRNPHLQINGKDDLRCSFPPDRRGSLVKSSNLTLLHCSLGIQMAITACMAILVVLVLTGLCWRFDGLWYVRMGWYWCMAKRRQYKKRPENKPFDAFISYSEHDADWTKEHLLKKLETDGFKICYHERDFKPGHPVLGNIFYCIENSHKVLFVLSPSFVNSCWCQYELYFAEHRVLDENQDSLIMVVLEDLPPDSVPQKFSKLRKLLKRKTYLKWSPEEHKQKIFWHQLAAVLKTTNEPLVRAENGPNEDVIEME
The following text describes a protein:
Function:
Cleaves thioester-linked long fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides.
Miscellaneous:
MISCELLANEOUS: Flies deficient in Ppt1 are viable and fertile, but accumulate abnormal autofluorescent storage material in the adult central nervous system and have a shorter life span.
Subcellular Localization:
Lysosome.
Sequence:
MISICCSRFSCILFLLFLIFSLVLSYIWWSPTKGGTNPEVLPVVLWHGMGDTCCVPFSLGAIMNLIVEQTKGGYVRSLQIGGNVLIDWQSGFFIHPNEQVDYVCKQLLQDEHLAKGYHAIGFSQGGQFLRAVAERCPNPPMRNLITLGGQHQGIFGLPMCPTLTEKPCDYITRLLDNAAYAPEVQKALVQATYWHDPIMENKYRLGSTFLADINNELFINKFYIENLQKLKKFVMVQFLNDTIVQPKESQWFQYYTTGQNKVIQPFTESKVYQDLGLDKMHRQGQLVFLGVEGDHLAISKAWFIQNIVPLLLEK
The following text describes a protein:
Function:
D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
Sequence:
MIGIVVSRADGASTHIWAQLREIEDFERIGPDAYRADGIEVRVFEELHTTIDDAADAFEAAVDMVVVVSRHSGDTGPLLSAHYTGNFGAAEYGGADRSVAPACPNAHHAVVDSLRSYAPPEYDVAMECTHHGPTSVGAPSMFVELGSSPAEWQDDAGARAVARAVRDLRGVPPHGDRAVVVFGGGHYTPRATRILADTDWPVGHVAADWSLTELGRPNAHRGVVDAMFTASGAAHALVEGDRPELTETIRDLGYTVVSETWVRETDGVPLSRVAALEESLTTVDDGLRFGEPAATHTGGYLVVELPDAVLDAAHAVDTAATVAAGRSHALAVTTVNAGRRLAGSAAFPDADAYEAFVDDVAAVLNAEYASVSRADGELTATREVFDPEAAAALGVPEGPAFGRLAGGEAIEHDGRTIAPAAVTSTETVRADVALHERPRERVRRPSDDEGKGN
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MTDVENQLPSNIEAPQMIAPSNDNPYAEYDNIAVSGNQQQTENMGYYPQQYDPNQGVAQNPAVASKSIHDLYVNTNFSEDISSWSNIRNEPSEHVGFWNTAESLTNFSQNATQLHKLNSIFWSSPFFLNLLVLFVLNCCNWQRQLYPDLRGYTLSLPILYTFLWAFLIIVLLVGEQFVPFISVKFGIFINLILHLTFYLIRCKVFWEYIFVWLTFVVLGLFFYVITLGRSKYDAYLTLVVNREVLLKLTFIILMISVITIISVVYVLTLYTSWAYWKNAMWLLQLYLVVSFYNIVCVLGNCTYMTTSYLTAKLYLTGERPTLQDLLAALRRGFVDNIGVACKMSYLLPISEFIHSTARYSPQLTVSELKASYPNVAELILAIAKPIVHIFEVLAKIEMKILKYPQRRAMAYCGIYGISYEEAVHRYCEVSYTKGSSLVDDAYMYDTQLIFKQFSSALACFFIDSTIRIQNYYWFRGFCLGSAFFLLFGLYYTIRTVMRGFLETVFVLFGELPENANKIHPGLYETLKQMYATSVRARNENLDRNSALLTQITTDYQNL