lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cytoplasm.
Sequence:
MRSSSATVIARTTMGYPYAFLLYFILQLRDVAADNETYTTEASTTPPNNADDETRSLLTSVLVPLLVCFVLILLAGYLLRSRKHRKADVNTGDKKMPNGILEEQEQQTVMLLSSSPTVYKKYFPIPVENLEEEFRIRSADDGKLFREEYNSLQPGNLHGTHEAANKEENKEKNRYPNILPYDQSRVILLPADGIPCSDYINASYIDGYKERNKFIAAQGPKQDTLNDFWRMIWEQKSATIVMLTNLKERKEDKCYQYWPDQGCWIYGNIRVSVEDVVVLVDYTIRKFCIQPVHDGCKAPRLITQLHFTSWPDFGVPFTPIGMLKFLKKVKFLNPVHAGPIVVHCSAGVGRTGTFMVIDAVIDMMNEEKKVNVFDFVLKIRNQRPQMVQTDMQYSFIYQALLEYYLYGDTELDVASLEKHLQALYTPAPHFDKIGLEQEFKKLTSVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGEEYTDYINASFIDGYRQKDYFIATQGPLPHTVEDFWRMVWEWKSHTIVILTELQEREQEKCCQYWPSEGAVTHGEINIEIKSDRLLDAISVRDFIVTSSQEKQTRLVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPIIVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQTIKSLRMQRPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK
The following text describes a protein:
Function:
Associates with the spindle pole body and maintains a functional interface between the nuclear membrane and the microtubule motor proteins. Involved in chromosome segregation during meiosis where it associates with the telomeres.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Nucleus membrane; Single-pass membrane protein.
Sequence:
MFTNTPVGGKRERQNGAHPAWSTLGANSAQIHQNTADLASKMHKLRYTKIRSPPTRVSIESITPKQRFPAPNFEQAYHSNIRYEQEESDNEEFENVVKNGHEASTNVFYESDGDDEEFVNEEYENSIDEESDDEGYSLNEDTTATNASFRYPMNQRSTRKSQFYSSKFKPLLWFGITLFSTLLIITLLHKGQEFYSRSFSSDNSQPSNSPVPNIPPASNDTKTSLKPDIIKDFTDSPSKVGGNEEFDYSTGDLITKKEFDKILQQKVEQLKQSLKEEMSNYKSSVPFEVELNDDWKFFIESTVRKYLTDPVSMPNFALLSTGAEVLPALTSKRYVRRPSAFIPRFTSYFFDSLVVRGHEPSIALTPNNAVAMCWSFQGSEGQLGISLSRPVYVTNVTIEHVQHKIAHDLSSAPKDFELWVQGMSSKMFVLLGKARYSLTEDSIQTFSFESSNYIVAEPIQNVILKIKSNWGNPNYTCLYQVRVHGTVPNADEQPIPSLGEKAESTAENTGQDSS
The following text describes a protein:
Function:
Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MVLLWLTLLLIAMPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDVECVKDADYSMLGKPRAGAQNLTCWIHDVDFLSCSWAVGPAAPADVQYDLYLNVANRRQQYECLHYKTDVQGTRTGCRFDDISRLSSGSQSSHIVVRGRSAAFSIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYELQIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECNQEEGTNTHAWRTSLLMALGTLLALVCVFLICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAGKAGLEECLVTEVQVVQKT
The following text describes a protein:
Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins.
Sequence:
MTRPPPSWRVSSAKRLSVLDFSEDDDRVEKDSSKFLGKFAKPKRKRNFTSPITKYKFLEYCKVQEKESAIQHIVVDDESVDIDMGSKQHNYSRCPGAQEKENANEPIIIDNEPVDGDMGFAGGIRAPHKEIRDESVDIDVNDVSHPLKLSLSPPICILQEDCIVKEASRLDAMMLSGSPNYENKSVHMISDDDDGSEISSASISISALKETEVPLKDPVPESSSVGHKIDILNNAVVVFPDVILYEDIYCTDSRLTFSRSYIRVEGSIVNGAKGTFNVEWAISDIISIESEWCQRVETAIINLLFKRNVFKGAGNANETSAIDKLTFSVYDPCWFEGQQAIKSLDVRYRSIWNVIFEEKVDDAFSMSNSMAIAKPCLNVLDEPFENIIYPKGDPDAVSISKRDVELLRPETFINDTIIDFYIKFLKNKIQPEDQHQFHFFNSFFFRKLVDLDKDPRNSCEGRQAFQCVHKWTRNVDLFEKDYIFIPVNYSLHWSLIVICHPDDESGRALKVSCILHMDSIRGSHRGLKNLIQSYLCEEWKERHSDTLDNVSSNFSLLPFVPLEQENSFDCGLFLLHYVELFLEEVPINFSPFKITEFSNFFNRNWFLPEEASLKRAHIRKLICEIIEDQSQQLPKGESVDKYPCSHFASTNEEETGVEFLTVEYSSLKMCEGHPSSPNTELGNEITLTSASSLSVVPQKLKEPGLESREFEPETSARLFYSRNCSRACHQSFTSPVEKAEEIGEQISDSLSDAKKSWKQNYMQVEELYDVNSSSITSVSESQKSSEIGLDDHDSGNIRETAGQESSSTSTENLSAYIVEDSQEAKGLHTGNDATSSDEELKGNRENISPGKIM
The following text describes a protein:
Function:
Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Also capable of generating a calcium signal. In terms of antagonist responses, would be classed with the D1-like dopamine receptor group. This receptor is an attractive candidate for initiating biochemical cascades underlying olfactory learning.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVDDNGSSPEVEGAEGAGAPLLALLRVDGLNQTQTRSPSPSFFGSYNISEDVYFYFNGLPTSTELVLNATTSATSATLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWRAARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLLCMCCPRKIRRKYQPTMRSKSQRFATRRCYSTCSLHGIQHVRHNSCEQTYI
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. Protects against staurosporin-induced cell death.
Subcellular Localization:
Cytoplasmic granule membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The first IBR-type zinc finger is the most crucial for interaction with UBE2L3, UBE2L6 and UCKL1; Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.
Sequence:
MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPAAQPPPAPAPAAAQGPPPEALPAEPAAEAEAEAAAAAAEPGFDDEEAAEGGGPGAEEVECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLEVQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQPESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQTVLKPEGGEARV
The following text describes a protein:
Function:
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.
Subcellular Localization:
Peroxisome.
Sequence:
MLRLVPTGARAIVDMSYARHFLDFQGSAIPQAMQKLVVTRLSPNFREAVTLSRDCPVPLPGDGDLLVRNRFVGVNASDINYSAGRYDPSVKPPFDIGFEGIGEVVALGLSASARYTVGQAVAYMAPGSFAEYTVVPASIATPVPSVKPEYLTLLVSGTTAYISLKELGGLSEGKKVLVTAAAGGTGQFAMQLSKKAKCHVIGTCSSDEKSAFLKSLGCDRPINYKTEPVGTVLKQEYPEGVDVVYESVGGAMFDLAVDALATKGRLIVIGFISGYQTPTGLSPVKAGTLPAKLLKKSASVQGFFLNHYLSKYQAAMSHLLEMCVSGDLVCEVDLGDLSPEGRFTGLESIFRAVNYMYMGKNTGKIVVELPHSVNSKL
The following text describes a protein:
Function:
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
TQQFLTKTTTTLPQQCVAGYIFRQGDIGTNWYAVLTGSLDVKVSDTSNHQDAVTICTLGIGTAFGESILDNTPRHATIVTRENSELLRIEQKDFKALWEKYRQYMSGLLAPPYGVMETGSNNDSKHPVIMWHVPLRVTSVPSEKILRAGKVLRTAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWIMQQSSCVHLRTQAVGMWQVLLEDGVLNHVDQEQHFQDKYLFYRFLDDEHEDAPMPTEEEKKECDEELQDIMLLLSQIGPDAHMRMILRKPPGQRTIDDLEIIYEELLHIKALSHLSTTVKRELAGVLVFESHPKAGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRDVEANTVRLKEHEQDVLVLEKIPAGSRTSNQGNTQPKYIVMSGTPEKILEHFLETMRLETTVSVHDFVMMHCVFMPNNQLCPALMPSQGTEQEKMDYALNNKRRVIRLVLLWAALYGDLLQEDEAAMAFLEEFYVSVSDDTRVIAALKDQLPELEKHKVLLHHFNTSDERTQKRQPIRESDEILFKVYCLDHTYTTIRIPVLSSVKEVISAVADKLGSGDGLILVKMSSGGEKVLLKPNDVSVFTTLSVNGRLFACPRDQFDTLTPLQEQEGPSTGTVGTFELMSSKDLAYQMTIYEWELFNCVHELELLYHTFGRHSFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFALIMGLSNVAVSRLTMTWEKLPSKFKKIYAEFESLMDPSRNHRPYRLAVAKLEPPVIPFMPLLIKDMTFTHEGNKTFIDSLVNFEKMRMISNTVRTVKFCRSQPFTPDASLANKNHQDVRNYVRQLSVIDNQRTLSQMSHRLEPRRA
The following text describes a protein:
Function:
Acidic protein which may be involved in interactions with other proteins or DNA.
Subcellular Localization:
Nucleus.
Sequence:
MAESENRKELSESSQEEAGNQIMVEGLGEHLERGEDAAAGLGDDGKCGEEAAAGLGEEGENGEDTAAGSGEDGKKGGDTDEDSEADRPKGLIGYVLDTDFVESLPVKVKYRVLALKKLQTRAANLESKFLREFHDIERKFAEMYQPLLEKRRQIINAIYEPTEEECEYKSDSEDCDDEEMCHEEMYGNEEGMVHEYVDEDDGYEDYYYDYAVEEEEEEEEEDDIEATGEENKEEEDPKGIPDFWLTVLKNVDTLTPLIKKYDEPILKLLTDIKVKLSDPGEPLSFTLEFHFKPNEYFKNELLTKTYVLKSKLAYYDPHPYRGTAIEYSTGCEIDWNEGKNVTLKTIKKKQKHRIWGTIRTVTEDFPKDSFFNFFSPHGITSNGRDGNDDFLLGHNLRTYIIPRSVLFFSGDALESQQEGVVREVNDAIYDKIIYDNWMAAIEEVKACCKNLEALVEDIDR
The following text describes a protein:
Function:
May function as somatic storage protein during early seedling development.
Sequence:
MGAFSSIILLVYVAATVLSISEGSERIHSLIRQPVAGTVSAESDPAGFSCLSWRFGVETKNIRDLPTVPKVCQHYVADYMLSDQFLQDSKVVTEEAFKYAKTVKLAGDGKDIWILDVDDSLITHVDFYAQNGFGTEIFDVTALINYLAQGISPALPESLKLYRRLLRLGFKIVLLTGRMEPSRNFTESNLKNVGYHSWEKLILRETGEWNDTTQRAHKSAERRKLVESGYRIIGNMGDQWCDLLGDYPGHRTFKLPNPVFYTE
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MASYDLTPRIAPNLDRHLVFPMLEFLQERQLYPDEEILKSKIELLSQTNMVDYAMDIHKSLYHTEDVPQDMMERRAEVVARLKALEEAATPLVNFLQNPSAVQELRADRSYNLQMLQDRHQIGPEQIEALYQYAKFQFECGNYSGAADYLYQYRALCTNSERNLSALWGKLAAEILMQNWDIALEELNRLKEIIDSKSFSSPLNQVQSRIWLMNWSLFIFFNNENGRTQIIDLFNQDKYLNAIQTNAPHLLRYLATAFIVNKRRRPQFKDFIRVVQQEQHAFKDPIIEFLACVYVNYDFDGAQKKMRECEELILNDPFLGKRVEEGNFSTVPLRDEFLENARLFIFETYCRIHRRIDLGVLAEKVNLNYEEAERWIVNLIRTSKLEAKIDSKLGTIVIEPNNPNVYEQLIDHTKGLSGRTYKLVTQVLEHAQAQPAR
The following text describes a protein:
Function:
Mitochondrial RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as rRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Involved in mitochondrial ribosome small subunit (SSU) maturation by catalyzing methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled (By similarity). In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4 (By similarity). Also acts as a regulator of innate immunity by marking double-stranded mitochondrial RNAs(mt-dsRNAs) generated in response to stress: catalyzes m5C modification on mitochondrial RNAs, such as a mRNAs and lncRNAs, with a preference for the termini of light-strand lncRNAs, promoting their degradation and cytosolic release (By similarity). Modified light-strand lncRNAs are then recognized by C1QBP reader and recruited to the mitochondrial degradosome complex, which promotes their degradation (By similarity).
Subcellular Localization:
Mitochondrion.
Sequence:
MAAPVLRCVRKLLKLVDFTPVPRRYRYKKKWATTEPQFTASRLALQNFDMTYSVQFGDLWPSIRVSLLSEQKYGALVNNFAAWDSVSAKLEQLSAKDFVSEAISHQKLEPESGLSPTPSLDCSPNLRCFTFSRGDVSRFPPARLGSLGLMDYYLMDAASLLPVLALGLQHGDTVLDLCAAPGGKTLALLQTGCCRNLAANDLSTSRTGRLQKVLHSYVPQDIREGNQVRVTSWDGRKWGELEGDTYDRVLVDVPCTTDRHSLHEEENNIFQRSRKKERQMLPMLQVQLLAAGLLATKPGGHVVYSTCSLSHLQNEYVVQGAIELLANQYNIKVQVEDLSHFRKLFMDTFCFFPSCQVGELVIPNLMVNFGPMYFCKLHRLP
The following text describes a protein:
Function:
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
Subcellular Localization:
Cytoplasm.
Sequence:
METFSYIEPLNINTNLVCKFCKKPLSDPIILVCGHLICCTCIPNELWIESGYTATCPECGKDYKKEDTTINIPICITEDLNGLKVKCNRCLEGVVINRVDFYEHIELYCKTPCELGCGAILTKNEIKSHLDVCSNFIVECPALDIYCKWKGPRKDLEEHIQKCNTEGVRPAIEALRESVQNLKEENQLLVKNLEKSNDILLCMVKFFFNPNDFNPLEGKDYNLIENINVKENETEKILEL
The following text describes a protein:
Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood.
Subcellular Localization:
Secreted.
Sequence:
KCRIIREFPDIVFKGLTLVQVSQKFGKAGFEDVKKVTEEIVHLNEDCCKGDAVECMMERMEATDHICEAKDKLSSKLADCCAKSILERTPCLLALPNDESDLSKELKNYYEDERVCENYKKDKLLFLAHFTHDYARSHQESSPQSCLRVSKGFEGLLEKCCASENHAECLKQAPILLEAALKEIEELRKQNCGALQLLGFRDYNIQLLFRYFFKMPQVTAPTLVELAGRMTKVAVYCCGLAENKQQTCAEEKLDILLGEMCEKEKHTFVNDNVRHCCVDSYANRRKCFTDLQRYPNYVAPKWDESKLHFNEDLCKGSEDDQIKKKLEVLVEYMKMKPDCGPEKLKEVVEAFRKIDIKCCAAEDHQKCFDDEKAGLLQIIEAH
The following text describes a protein:
Function:
Beta-arabinofuranosyltransferase that transfers specifically an arabinosyl residue from UDP-arabinofuranose to the monosaccharide galactose or beta-methyl-galactoside in vitro. Catalyzes the addition of a beta-arabinofuranose residue onto a beta-galactosyl residue of an Yariv-precipitable wall polymer in vivo.
Domain:
The conserved DXD motif is involved in enzyme activity.
Sequence:
MMSRIEAYQSDIAVLMDPETVLLPDFISALSYAHELGRDWLLVSSSVEIPRFPFHWDETRHFWRQDNGKRVRFRELQKMISLRSLQSNSSASKMIMAWNNIDMPLHCGVLPPFLYQRGTHNQWIINEAMSCKRRFVFDATSTISSFFLGNAENIYNRSDNVSEPKTRNWEYVGNSHLGQLYGSLYSRSYTLPKLLKCNRRYIFVSASERSTDLSIPKGKSLGFRTREKISACITRTKSRSLKLDFVQKDETVPPLKFPFDLESLLPLVADKNRTVVLSVAGYSYKDMLMSWVCRLRRLKVPNFLVCALDDETYQFSILQGLPVFFDPYAPKNISFNDCHFGSKCFQRVTKVKSRTVLKILKLGYNVLLSDVDVYWFRNPLPLLQSFGPSVLAAQSDEYNTTAPINRPRRLNSGFYFARSDSPTIAAMEKVVKHAATSGLSEQPSFYDTLCGEGGAYRLGDDRCVEPETNLTVQFLDRELFPNGAYGDLWLKEDVRAECEKKHCFVLHNNWISGRLKKLERQMMKGLWEYDASMRMCV
The following text describes a protein:
Function:
Peptide hormone that functions as endogenous ligand for the G-protein-coupled apelin receptor (APLNR/APJ). Functions as a balanced agonist activating both G(i) protein pathway and beta-arrestin pathway of APLNR. Downstream G proteins activation, apelin can inhibit cAMP production and activate key intracellular effectors such as ERKs. On the other hand, APLNR activation induces beta-arrestin recruitment to the membrane leading to desensitization and internalization of the receptor. Apelin also blunts mechanical stretch-induced hypertrophic induction from APLNR. Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (By similarity). Involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates. Plays a role in early coronary blood vessels formation. Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity). May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior.
Subcellular Localization:
Secreted. Secreted, extracellular space. Note=Abundantly secreted in the colostrum. Lower level in milk. Decreases rapidly within several days after parturition in milk, but is still detectable even in commercial milk.
Sequence:
MNLRLCVQALLLLWLSLTAVCGVPLMLPPDGTGLEEGSMRYLVKPRTSRTGPGAWQGGRRKFRRQRPRLSHKGPMPF
The following text describes a protein:
Function:
Probable transcriptional regulator involved in developmental processes (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence (By similarity). Induces pre-placodal ectoderm (PPE) gene expression in regions where RIPPLY3 is absent. Plays a role in the formation of the anteroposterior (AP) axis during embryonic development; required to establish the posterolateral border of the pre-placodal ectoderm (PPE) acting downstream of the retinoic acid receptor (RAR) signaling (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MISAISSPWLTQLSHFCDVAAFTANSLSSLNASGGYHLSPSPGDPYSQHEPHYEPCSASQHSYSFGHACPEPESGASSSSCASSTPGSGSTGSSGSSKAPVKKNPKVANITVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKIFGMDPMADYMLLMDFVPVDDKRYRYAFHSSSWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDPRKDSEKYAEENFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNHRPGSLPLMNAFARSRNPVSSPPQNGSDKDGDGRREYERDTSGTPLHGDAAHQQLMSRVLSPSLPVPGGLVPLSTGRPSPPHELRLDPHSQGSEPLHHHPYKYPTSYDHYLGAKTRPAPYPLPSIRGHGYHHHPMNPAAANMYSGAGAPGSYEYGPR
The following text describes a protein:
Function:
Acts as a co-chaperone for HSP90.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKSTDSKQNLLLNNRNPEVLWAQRSDKVYLTVALPDAKDVFVKCEPQGLFSFVAQGLQDESFDFSLELYGPIVPEGCKTEVGLRNILCSIQKEQKGWWKRLLKSEEKPAPYIKVDWNKWCDEDEEESASDLASDDDTAEYVGQDDGSSDDEGMLYLPDLEKAKRKLATSDF
The following text describes a protein:
Function:
Required for initiation of chromosomal DNA replication. Acts at the origin of replication. Also has a role in minichromosome maintenance.
Miscellaneous:
MISCELLANEOUS: Present with 1730 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MYYGISQFSEAYNKILRNSSSHSSCQLVIFVSCLNIDALCATKMLSLLFKKQLVQSQIVPIFGYSELRRHYSQLDDNINSLLLVGFGGVIDLEAFLEIDPQEYVIDTDEKSGEQSFRRDIYVLDAHRPWNLDNIFGSQIIQCFDDGTVDDTLGEQKEAYYKLLELDEESGDDELSGDENDNNGGDDEATDADEVTDEDEEDEDETISNKRGNSSIGPNDLSKRKQRKKQIHEYEGVLEEYYSQGTTVVNSISAQIYSLLSAIGETNLSNLWLNILGTTSLDIAYAQVYNRLYPLLQDEVKRLTPSSRNSVKTPDTLTLNIQPDYYLFLLRHSSLYDSFYYSNYVNAKLSLWNENGKKRLHKMFARMGIPLSTAQETWLYMDHSIKRELGIIFDKNLDRYGLQDIIRDGFVRTLGYRGSISASEFVEALTALLEVGNSTDKDSVKINNDNNDDTDGEEEEDNSAQKLTNLRKRWVSNFWLSWDALDDRKVELLNRGIQLAQDLQRAIFNTGVAILEKKLIKHLRIYRLCVLQDGPDLDLYRNPLTLLRLGNWLIECCAESEDKQLLPMVLASIDENTDTYLVAGLTPRYPRGLDTIHTKKPILNNFSMAFQQITAETDAKVRIDNFESSIIEIRREDLSPFLEKLTLSGLL
The following text describes a protein:
Function:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. The three isoforms seem to have a different level of activity.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.
Sequence:
MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
The following text describes a protein:
Function:
GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MAEPSKQDISAIFKRLRSIPTNKVCFDCAAKNPSWASITYGVFLCIDCSGTHRSLGVHLSFIRSTELDFNWSWFQLRCMQVGGNASAIAFFNQHGCTSSAANTKYNCRAAQLYREKIKALATQATRSHGTELWLDSQAPVSPTSPDDKQVDFFSLHSQSPLLEPIQLLLDEGGVHPEQTSPDNLNFDKMTLSSSTTKTSSTVEKDKDPNGNVEKGPSVEMLSVSPTANLEASSLFKKKPAGTKKTLAAKKGGLGAQKVSSQSFSEREKKAQDADKRREKDESFTAARKEIASEESIAPSLRLTYKEFEQQKKLEDHKLKGLEGKKKEQVDRLGMGMGMRSGVSHSVTSEMHTIQQESPLGAKTTKARRFTDDDEDEGSFSSRSLSRFEDQSDIFSSRWTDGSDGGGWMKESKTPEPDFFMSSTITSFDDRAVARKKSESVPVSDSEEARRKFGNDVKAISSDMYFGKQDDSEYEAKTRLERFSGSASISSADLFDDPKKQTGSSYRLTNMLPNAPDMSQLRMGVRSVAGKLSVMASGVVNSIQDHYNS
The following text describes a protein:
Function:
May be a histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code (By similarity). Represses transcriptional silencing by negatively affecting heterochromatin stability.
Subcellular Localization:
Nucleus.
Domain:
The JmjC domain mediates the demethylation activity.
Sequence:
MDSWLEYDDIINQDIDIPSNDLSGSGTLCVGVHSSLLENSLNSIDSFISSKEEISWCGNQSTPIATKSHLSCINPQYVNPFDTSPVSVDTEFQDTYLLDAPSFAQPHFSERQSVDKTRSRCLSRNRRRKRHPNLHKNHQRLLGMSFPQDGFRRMPAESVNFSYFRDTGFNEPTIFPSSDTQNTRQLNLSKIATLIGYDCPLALVDVVTQKQIPNKMDMESWVKYMSLEPSKRGRIYDVLSLEVSTTKLAYYVRKPNIVRDLDLVNTVWPPGSFALGEYPHVDTYCLMSAENSYTEFHIEFGGSSAYYNILDGCKIFYLIPGTSKNWEAYTAWLTSSNDSDKKFLPNMVDVCYCVEVHSQQTILVPSGWIYAVVTPCDTISIAGNFLTFLHIYPQLSIYNLELQLGIEKEYQYPYFESIMWYTAIHFYLAFPDNSSRDGIDDIIAEYETGRLFDINAFTEQELDGFEELLNYLYIRAQILRDCDIIIDIYNEPVKISKNNGYNSAYTMVPPDLDEICVDFVQKFGAWITYHHRRSAKHPSCNCFSHLQTKLIDSGPKPANNSYQHQSNFIGVVISTNHNIIKKCQESQIQTGKNNCSFQLVKKRIKSTKKAPSWRSIIKAFKKRENTRCNFLSSLHATTFREDIVVRPKIKSFVLEQLIFQALFSFAINWTPSFFLNHSNFENIALSKETFNFGGEANCENTDTTLFTTWGDQGFRPSDSICYNDFNLLETANSDAEASIHELELQPLNAVNEREVDISQTDMTPSTALDTRVDTRVDSLPEFSNLILSPSSNDDSFQLDDLLSPSSSNLKQQIQKVVPQNSLEFSVGEKEKKAAEYSLLHTFSYKRLSMENEKPDTTKVPLKYNIQHEEMKAYRRKNDLEYIDQHFASSKSGISNGRNNNKEVNLTKAENVGIKKRRIMKNENNIYDFEDHSPVREKWGHRLRSRGAS
The following text describes a protein:
Function:
E3 ubiquitin ligase effector protein that interferes with host's innate immunity. Functions to alter host cell physiology and promote bacterial survival in host tissues. Catalyzes ubiquitination of human gasdermins GSDMB and GSDMD, promoting their degradation by the proteasome, thereby preventing cell death. In contrast, activates host cell pyroptosis in mouse cells: catalyzes ubiquitination of mouse Nlrp1b allele 1 protein, releasing the cleaved C-terminal part of Nlrp1b, which polymerizes and forms the Nlrp1b inflammasome followed by host cell pyroptosis. Does not catalyze ubiquitination of mouse GSDMD.
Subcellular Localization:
Secreted. Host cytoplasm. Note=Secreted via Mxi-Spa type III secretion system (T3SS), and delivered into the host cytoplasm.
Domain:
The LRR (leucine-rich repeat) domain forms a slightly curved solenoid and may mediate interaction with target proteins.
Sequence:
MFSVNNTHSSVSCSPSINSNSTSNEHYLRILTEWEKNSSPGEERGIAFNRLSQCFQNQEAVLNLSDLNLTSLPELPKHISALIVENNKLTSLPKLPAFLKELNADNNRLSVIPELPESLTTLSVRSNQLENLPVLPNHLTSLFVENNRLYNLPALPEKLKFLHVYYNRLTTLPDLPDKLEILCAQRNNLVTFPQFSDRNNIRQKEYYFHFNQITTLPESFSQLDSSYRINISGNPLSTRVLQSLQRLTSSPDYHGPQIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEEQKYEMLENEYSQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSENGSRLHHS
The following text describes a protein:
Function:
May play some role in mitochondrial processes.
Sequence:
MRSQCETVLPGLETTMVFPIAKLASLAIKQLSKPVARYAKEGAKRSEFFKRYVCMPPAQLYHWMEVKLKMRILGLGKTKPGSVAPLNEQMATELGAEMLGESIVFMVGVLTLYAEYWRQSRNTQIKEDSQNERLKELEEKLLDLQVVTEKQDMQIRHLSRLLAGFGPPHQVTQDSNQTVRQPGK