lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Required for the localization of CENPC but not CENPA to the centromere. It however may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associates with active centromere-kinetochore complexes throughout the cell cycle.
Sequence:
MAGRLSESVGSGPGAEAETAADPDAKRDVLEHLCARTHLKQLVMEFDTACPPDEGCNSGAEVNFIESAKETLEEVGKVKSAFESKALVIKRIQLMDALRKRVKENDGCARLIVETMRDIIKLNWEIIQAHQQARVIRENLNDIRRKRYFLKQAEGEKALRIFTTVRKKKEVVRMKIAEKLKFIHRNVQYERKVTTLVQNILQNIIVGCQINWAKDPSLRAIILQLEKDISIQNLL
The following text describes a protein:
Function:
Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.
Subcellular Localization:
Cytoplasm.
Sequence:
MKLVEEEKILPNSSGIINIVPEEPDDMWLLYNLISKGDVIVADTTRKTAFGRVRLTLEIKITAIDYDKVGSVIRVAGRNLVHNEHVDAGAFHTIEIERNKPFDLKKKVWDSDAIEELRSYGNAAKADLAVLLIQDVSAELYSIGKIATTLCANIEAPSKTNRAAKSKSQSKSNKFFENILTEFVKHVNFNFVSLVIIASPVGTEFRQYLLAESRRQKLQQIEENKERVVVVNTSGKATLKAVLQEPEVMKLIRGKNGAVEITAWKDLCDMLSNDSSRACYGSKSVEKANELMAIDTLFISDELYRSANHGSRHKYTDLVKSVKKAGGKALVYSHNHVMGEQLGQLTGIAAILRFPLPDLDDMEL
The following text describes a protein:
Function:
Transcription regulator.
Subcellular Localization:
Nucleus.
Sequence:
MAQLPPRAPSAAAQDHWSAAGEFLGFAAARRGAHRRSASDPAAFLEAVPMDDVIAGDDFDRLDDEQLMSMFSDVDAPAVSDGGGGAERAGDAQLMDLGDAEDGMAAASSPASARAAADGVADPKRVKRILANRQSAQRSRVRKLQYISELERSVTSLQMEVSALSPRVAFLDHQRSLLTVGNSHLKQRIAALAQDKIFKDAHQEALKKEIERLRQLFHQQQIKATTGGADIAAAASMQARQELLACEGAAIR
The following text describes a protein:
Function:
Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MSNQGRESWSRCSPGPPPPQVNFAGAADVASGPRRGSGGQGCASVPAIAALLWFQAACDLQGQAGCRRGNCLCLWGLPRPPRGRRGWCQQRGYTGPGNSLPQRHGVRRGLQMGLWGCAFGCRPPGGEGRCTCRRGPCVTLGSCSCCGFWCWQWVALSTSSGLGESEPWGARASRCRRGGGGQPAALRATPGLGEPGLVLWFSHLLRVFPVVAPGSPFLRFLAPLVAGLGGSGRRAGSCGTDLLASPLCSRRVCAIGAPRGPESESFVQRVYQPFLTTCDGHRACSTYRTIYRTAYRHSSGPASPRPRYACCPGWKRTSGHPMACGAAICQPPCQNGGSCVQPGRCHCPAGWQGNTCQTDVDECSAGGSSCPQCCVNTAGSYWCQCREGHNPSTDGVLCLPERGTPRVAPNPTAGVDTAVEEEVQRLRSRVDVLEQKLQLVLAPLHSMASRALEHGLPDPSSLLTHSFQQLDRIDSLSEQISFLEEQLGSCSCKKQP
The following text describes a protein:
Function:
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
Subcellular Localization:
Cytoplasm.
Sequence:
MPDIFTDNTDKQDSDPSRQGFEGQPNVVIVRYGELALKSTGVRNWYEKILMKNIAAMLDSRNIPYSLLRREWGRIFIETTDPRAAEAAADVFGVVSTSPALVTKPDLESAARTCAFLGTGLIREGESFAIRARRSGNHPFSSADVGRNCGDAVWDSLEKEGKHPRVNLTSPDKEIFVEMRQNLAYVYLETVKGVGGLPLGTQGSMVVLMSGGLDSPVAAWLMMKRGVMITPVYCNNSPYAEDAARERAFDCIRQLQTWAPGHQFATYEIPHGPNLRAFIGTCDRKNTCLLCKRMMYREAYEVMKKVGASGIITGSSLGQVASQTAANMHAEIYQLAIPIYHPLIAFDKSEIVDIARRIGTYDISTRPAGICTAVPERPEVKANYDLIVLEEKKLGIETMVGDALKAVKILKL
The following text describes a protein:
Function:
Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.
Sequence:
QGSCAAAYECGFLGDLADSSTESGNLLDCSRDMENKETLRGLQKMDDRPEERMIREKLKATCMPAWKHEWLERRSRRGPVVVKPIPVKGDGSEMNKLSLEPQSEGQSSASSPTQKGRRSPSPSSSSSSSSRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETSRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQTCSCGRGTFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHTLSSSTSTSSSENSMKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELPSPVDSSVLHVVQQQTQQQSTIGSQRRTQDSNFNLTHYGVQQIPSAYKDLAEPWIQVFGMELVGCLFSRNWNIREMALRRLSHDVSGALLLANGESTGSSGNSNGNNTSAGALGIASGSSQATVSGDVVVESCCSVLSMVCADPVYKVYVAALKTLRAMLVYTPCHSLAERTKLQRLLKPVVETILVKCADANSRTSQLSVSTLLEMCKGQAGELAVGREILKSGSIGIGGVDYVLNCILATEIESSNWQALLGRLCLIDRLLLEFPGEFYPHIVCGDVLQADAIVGRYKKLLSLLNFALLSIDNSHSMVGKLSRRVFLSSARMVARVPHVFVKLLEMLSVTSSTHYTRMRRRLMAIADEMEVAEAIQLGMEEIQSGECRHEDFLQLPVPDNSPEATENNTPNNTVQLSGKNGKGLSDKKLSAGPEDISETLTSLVVGHPVSSLTTEQPKPAVQTKGKPYSQCLNSSPSSSHSQSLFPTLLSPSNPSVSAGTVTDVSKLRPQGFIPCKIPSPSPQTQRKLSLQFQRSCSENKEPDKLSPVFTQARPLPSSHIHRPKPSRPTPNDMNKQGETSKNSMTLDLNDTSHCDGNGSNSSAVIPSEETVFTPVDEKCRLDVNAELNSSIEDLLEASMPTSDGTVTFKSEVAVLSPERAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIIPQLQVENGEDIIIIQQDTPETLPGHTKAKHHYREDAEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVIINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGHRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCVVIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVTLRCLELQPQDRPPSRELLKHPVFRTTW
The following text describes a protein:
Function:
May be signaling molecules that resemble neuropeptides.
Subcellular Localization:
Secreted.
Sequence:
MQLFCDSEKVIRTSESVDWEDRTVPGTLVRNVVHSRITSPVHLFVKQPLGSKPAYADNLENFGDWLANRTEIQEPLARTKRRPIVKTGKFKKMFGWGDFHSNIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGLGNVSVSLVPPSKIVEFEVSTQSSLETKESKSFNCHIEYEKTDRAKKTALCNFDPSKICYQEQTQSHVSWLCSKPFKVICIHIAFYSIDYKLVQKVCPDYNYHSETPYLTSG
The following text describes a protein:
Function:
Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'.
Subcellular Localization:
Nucleus.
Sequence:
MEEEQPPAKKRNMGRSRKGCMKGKGGPENATCTFRGVRQRTWGKWVAEIREPNRGTRLWLGTFNTSVEAAMAYDEAAKKLYGHEAKLNLVHPQQQQQVVVNRNLSFSGHGSGSWAYNKKLDMVHGLDLGLGQASCSRGSCSERSSFLQEDDDHSHNRCSSSSGSNLCWLLPKQSDSQDQETVNATTSYGGEGGGGSTLTFSTNLKPKNLMSQNYGLYNGAWSRFLVGQEKKTEHDVSSSCGSSDNKESMLVPSCGGERMHRPELEERTGYLEMDDLLEIDDLGLLIGKNGDFKNWCCEEFQHPWNWF
The following text describes a protein:
Function:
Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
The AWS and SET domains are necessary for transcription repression.
Sequence:
MSNNNFQESSNNTSSPSKRSTPMLFLDAENKTQEALTTFELLNACTYQNKYVGSANVTTTATTSTKTSNSTSTKSHQQQHRRKLEYMTCDCEEEWDSELQMNLACGPDSNCINRITCVECVNRNCLCGDDCQNQRFQNRQYSKVKVIQTELKGYGLIAEQDIEENQFIYEYIGEVIDEISFRQRMIEYDLRHLKHFYFMMLSNDSFIDATEKGSLGRFINHSCNPNAFVDKWHVGDRLRMGIFAKRKISRGEEITFDYNVDRYGAQSQPCYCGEPNCIKFMGGKTQTDAALLLPQMIAEALGVTPRQEKAWLKENKSIRNQQQNDESNINEEFVNSIEIEPIENQDGVTKVMSALMKTQHPLIIKKLIERIFLSNDQDDINVMFVRFHGYKTISTILQDLLVAKNSGKESETTDNNDIDNSTGDDDQDKDELIIKILKILVSWPAVTKNKIASANLEEVVKDIQTNNENSNNNDEINQLCTSLLDRWSKLEMAYRIPKQESVPTNNAAAAATTTATATGTTTSASPFERISSHTPEVGGTNTPSSTSQQQQQQNSRDAGLPENWRSAFDKNTGGYYYYNLVTKETTWERPLGSLPLGPKPPSGPGLKGRINKYNEIDLAKREELRIQKEKEMKFIEMQNRDRKLKELIEMSKKSMNNIGGSSGTTITAATINGLSDNGGNNNGNITGIYGDDKHSKHHHHHHDKHLKNGPRNTSTSSSSGNNVEKIWKRIFAKYIPNIIKKYESEIGRDNVKGCAKELVNILTQSEIKHGNSLPSSSSSNGYSMELSDKKLKKIKEYSHGYMDKFLIKFNNSKKHKSTMGSKGSDNHKRKHNGDGDNGVKRSKV
The following text describes a protein:
Function:
The function of the small subunit is not yet clear.
Subcellular Localization:
Nucleus.
Sequence:
METAWSNILNYKNVSDRYILTEKDKKGAFTRQYFEVYEARLKELKPRILENAEREIGKGKFTHSQLSDAKQDEEIFVVGVIVKRIAARPSILKSLLNEDKVAYDDYEEDAEEDEVKRYAGSIEDRIELESDKQTVRLEGNISMDECATGCCVGVLGKLGKEGVFHVNRLVWPSVKVPKKVAVDGTIAFVSGLDLTGDLEDDRLTISGLEFMADWMNVQVGNENQCPPIDRLVVIGPLVETKSNGCDVQSVVRTLTLSRAEKHSSTASLITVDKIINSIAEKPLVNTVDVTPGVGDPCSSMWPLPPIHRVCLPRCGMSDKKVNLVTNPYEFEVNGLRVMTMSGENVSELLRTSLKWTGADAIENIIKWQHVAPNCPDTLDAFPVAERDPLIMDITPHVIICGNQPHAEFRHIPIDGSNCLVVCLPKFSKTRVACFLNLSDLSLKWQNFDHQF
The following text describes a protein:
Function:
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
Sequence:
MTLRFKSRIEQALNEREHSRLTRRLQLLDRSAQGELIQQDRTYLNFSSNDYLGLANDAELVQAWQTGLARFGAGSGASPMVTGFSSAHAELEHELCHWLGYERAVLFSSGFSANQALLFTLLEKEDLLLQDKLNHASLMEAGMLSPATMKRFKHNDTEHLRQLLHEQSNSLVVTEGVFSMDGDCAPLAQIATLVKQRAWLMVDDAHGIGVLGEDGAGSCQAAGIHPEILVVTFGKAFGLAGAAVLCDAHVGDYLTQFARHHVYSTAMPPAQAHALTHAARMIQSQSWRREQLAELLACFDEQCRNIPGFVATQTPIKPWLLGSSDSALSASHELKQQGIWVSAIRPPTVPVGSARLRITITAAHTQAQIRRLSEQLKHVMEKDT
The following text describes a protein:
Function:
Binds preferentially double-stranded telomeric repeats, but may also bind to the single telomeric strand.
Subcellular Localization:
Nucleus. Chromosome. Nucleus, nucleolus. Chromosome, telomere. Note=Localized to the nucleolus during interphase.
Domain:
HTH myb-type domain confers double-stranded telomeric DNA-binding while the H15 domain is involved in non-specific DNA-protein interaction and multimerization.
Sequence:
MGAPKQKWTSEEEDALRRGVRKHGAGKWRTIQKDPQFSPILSSRSNIDLKDKWRNLSFSASGLGSSKVRVPKITGSSSSPSSSSQALLLPAANNVTEAMLPADADKKPRDGKTPPKYGAMIMEALSELNQPNGSDIDAIFDFIKQRHVVQSTFRRFLPSKLRRLADSNKIEKVDNFYRLPDSFATRTPAQIKVSDPKQKDPSKASKTIGLFAASSPALEAAMAAAVKVTDAEAKAHDAHDQMMEAERMLKMAEDTESILTIAAEIYDRCSRGEITTLVPVAQREF
The following text describes a protein:
Function:
Transcription factor that specifically controls transcription of the zearalenone biosynthesis cluster genes.
Subcellular Localization:
Nucleus.
Sequence:
MQSTESFHALPTRSDVEDPNERRKIQNRIAQKKHRQKMKRRIEELETKVNNQCQTSNWTSHAPTDSCQEQQFLDNTDFGLMLEDDLLYRELSASLDGAGLTAVAQMHDSPRPNQQQRLSVSGMPSSPTSTSNVAQRGLSIGDHSSASNHLSSLSLVPGSTEGSLPTRQHDNLCNQDLRDMVPEEKMSRILKVIQDAGYKDMDSFMTEYYVRDFDASSHVSAVQRQSRSRRLRGFLEQLRVGAESWSDYEAHDYQQEISKSAEAIYAKELDVFSTTTLGENASFQGLASLYRVLQSTVGSDIENHLRHEQSMMQRQVSEIVHRQVYTFNPAQC
The following text describes a protein:
Function:
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity.
Subcellular Localization:
Nucleus.
Sequence:
QIHYLAGLLIEFQNMKCVLPGANVKLFAKAIHCLAKLGHYVYFEPLDTGLALKTVNSSRSAYVSILFMKPLFQVYNAGSDIDLTVDDDNLPITRCKVALKTLLQVFKSLANIERSVETCDIDLDGDECRLVFQLKCKHGITKTHHLTFQECESLQAIFAKDLSPNVLKCDHKVLSDVVINFSSSLEEITMLVSPCKVVLRSYSDDESDEIAQLMKTEVSLNPEEFSQYQIGVDTDVTFCLKDVRAILAFCEVAAMPVNIHFEVGGKPIIFSLGHNGYFRANFVIATIATDKNSQHSNATANFTTNTTFPTTNKRSFVKPSRSKVAPKPLRKVSAQKTNAKPQPTKLPQPKDCDSINSEHDVSPEIPLQGGEQTNATRYEGFNSPSPKQPCFKNVKTVFFAATQPNDLDRTVLVLAPDSDNEDGT
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MESSNRSSNNQSQDDKQARFRGVRRRPWGKFAAEIRDPSRNGARLWLGTFETAEEAARAYDRAAFNLRGHLAILNFPNEYYPRMDDYSLRPPYASSSSSSSSGSTSTNVSRQNQREVFEFEYLDDKVLEELLDSEERKR
The following text describes a protein:
Function:
Member of the two-component regulatory system PrrB/PrrA that is involved specifically in early intracellular multiplication of Mycobacterium and is essential for its viability. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of PrrA. In turn, PrrA binds to the upstream promoter regions of target genes including itself to positively regulate their expression.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNILSRIFARTPSLRTRVVVATAIGAAIPVLIVGTVVWVGITNDRKERLDRRLDEAAGFAIPFVPRGLDEIPRSPNDQDALITVRRGNVIKSNSDITLPKLQDDYADTYVRGVRYRVRTVEIPGPEPTSVAVGATYDATVAETNNLHRRVLLICTFAIGAAAVFAWLLAAFAVRPFKQLAEQTRSIDAGDEAPRVEVHGASEAIEIAEAMRGMLQRIWNEQNRTKEALASARDFAAVSSHELRTPLTAMRTNLEVLSTLDLPDDQRKEVLNDVIRTQSRIEATLSALERLAQGELSTSDDHVPVDITDLLDRAAHDAARIYPDLDVSLVPSPTCIIVGLPAGLRLAVDNAIANAVKHGGATLVQLSAVSSRAGVEIAIDDNGSGVPEGERQVVFERFSRGSTASHSGSGLGLALVAQQAQLHGGTASLENSPLGGARLVLRLPGPS
The following text describes a protein:
Function:
Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also a component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC.
Subcellular Localization:
Chromosome, telomere. Nucleus.
Sequence:
MEKPHGHVSAHPDILSLENRCLAMLPDLQPMEKLHQHISAHSDILSLKNQCLATLPDLKTVEKPHGYVSAHPDILSLENRCLATLSDLKTMEKPHGHVSAHPDILSLENRCLATLPSLKSTVSASRLFQSLQISHMMQADLYCVNNSNCLLSEPPSWSAQHFSKGLDLSTCPTALKSLSATGTVQEATLGRWFDSEEKKGAETQMPSYSLSLGEEEEEVEDLALKLTSGDSESHPEPTDQVLQEKKMALLSLLCSTLVSEVNMKDASDPTLAAIFENCRELAPLEPEFILKASLYARQQLNVRNVANKILAIAAFLPACRPHLRRYFCAIVQLPSDWIQVAELYQSLAEGDENKLVPLPASLRAAMTDKFAQFDEYQLAKYNPRKHRAKRHPRRPPRSPRMEPPFSRRPFPRYIVFLRDEQKKFEKAYDTVSEKKNPPRFTLKKLVQRLHIHEPAQHVQALLGYRYPSNLQLFSRSRLPGPWDSSRAGKRMKLSRPETWERELSLRGNKASVWEELIENGKLPFMAMLRNLCNLLRVGISARHHELILQRLQHAKSVIHSRQFPFRFLNAHDSIDALEAQLRNQALPFPSNTTLMRRILTRSDKNRPRRRFLCHLSCQQLRTVMRVPVMYEKLKREKLRVHKARQWKYDGEMLNRYRQALETAVNLSVKHSLPLLPGRTILVYLTDANADRLCPKSNPQGPPLNYALLLIGMMITRAEQVDVMLCGGDTLKTAVLKAEEGILKTAIRLQAQVQEFDENGEWSLNTFGKYLLSLAGQRVPADRVILFGQSMDEGMINVAKQLYWQHVNSKCLFVGVLLRRVQYLSPDLNPNDVTLSGCTDGILKFIAEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSLRPLEEDTPSPLAPISQQGWRSIRLFISSTFRDMHGERDLLLRSVLPALQARAAPHRISLHGIDLRWGVTEEETRRNRQLEVCLGEVENAQLFVGILGSRYGYIPPSYNLPDHPHFHWAQQYPSGRSVTEMEVMQFLNRSQRLQPSAQALIYFRDSSFLSSVPDAWKSDFVSESEEAACRISELKSCLSRQKGITCRRYPCEWGGVAAGRPHVGGLEEFGQLVLQDVWNTIQKLYLQPGALLEQPVSIPDDDLVQATFQQLQKPPSTARPRLLQDTVQQLMLHHGRLSLVTGQSGQGKTAFLASLVSALQAPDGAKVAPLVFFHFSGARPDQGLALTLLRRLCTYLRGQLKEPGALPNTYRSLVWELQQRLLPKSAESLHPGQTLVLIIDGADRLVDQNGQLISDWIPKKLPRCVHLVLSVSRDAGLGETLEQSQGAHVVALGPLEASARARLVREELALYGKRLEESPFNNQMRLLLVKRESGRPLYLRLVTDHLRLFTLYEQVSERLRTLPATVPLLLQHILSTLEQEHGPDVLPRALTALEVTRSGLTVDQLHGVLSVWRTLPKGTKSWEEAVAAGNSGDPYPMGPFAYLVQSLRSLLGEGPLERPGARLCLPDGPLRTAAKRRYGKRPGQEDTAHILIAAQLWKTCDADASGTFRSCPPEALVDLPYHLLQSGNRGLLSKFLTNIHVVAAHLELGLVSRLLETHALYASSVPKEEQKLPEADVTVFRTFLRQQASILSQYPQLLPQQAANQPLDSPLCQQAPLLSQRWHLQHTLRWLNKPQTMKNQQSSSLSLAVSSSPTAVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSLVSGCDGISACLFLSDDTLFLTAFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDRRLLATVCLGGCLKLWDTVRGQLAFQHTYPKPLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASVRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVHVWSGSLGRPRGDLGSLPLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKERSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVRLWPRQLLTLPHKAEDFPGGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKAPILIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEHVVSVGRDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTIGLDGATRLWHPLLVSQTHTFLGHSGPVRAAAVSETSGLLLTASEDGSVRLWQVPKEADDTCIPRSSAAITAMAWAPDGSMAVSGNQAGELILWQEAKAVSTAQAPGHIGALIWSSARTFFVLSADEKISEWQVKLRKGSAPGNFSLHLNRILQEDLGVLTSLGWAPDGHFLILAKADLKLLCMKPGDAPSEIWSSYTENPMILSTHKEYGVFVLQPKDPGVLSFLRQKESGEFEERLNFDINLENPSRTLISITQAKPESESSFLCASSDGMLWNLAKCSPEGEWTTGNIWQKKANIPETQTPGADPSTCRESDASMDSEPTSQLKTRQRRKIHSGSVTALHVLPELLVTASKDRDVKLWERPSMQLLGLFRCEGSVSCLEPWLGANSTLQLAVGDVQGNVYFLNWE
The following text describes a protein:
Function:
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MHESQLTTSAAKPSRLGWFDDVLLLGIMAVLAGCGLIYEYLLSHYAGRILGALEAAIYTMIGLMIVSMGLGAFAARKIKDAFTGFVVLELTVALCGSLAILITAAVIGFGQQLPMLIASTLGLPPDQLPEGGMIGTLQKLSEYLPYFWGVLLGLMIGMEIPLIARVRQSLSDEHLLHNAGTIYGADYIGAGIGAAIWVGFMLAIDIQLAAALTASFNLLAGFVFIWRFWQKIQRPKLLLAAHLVVTGVLLLLAIQGPSWEQQFNNLLYKDKVVYAKATRFQQLTFTERLRGNGLSPVYALYINGRLQFSSSDEHIYHAFLVHPTLAASARHNKVLIIGGGDGLGLKQVLRWEPEQVTLLDLDAALVQLFKSPDPDMPERLSQALLSLNGNAFNDPRVTVIHDDAFNGVDKLIAKGDKYDAIIVDLPDPSHPDLNKLYSDYFYRKLKELISNDGALTVQSTSPYHAQKAFISVAKTLALAGFDVKQYHHNVPSFGEWGWSIATLDGKDAQHRLAQLTKLPIADDWLTLGLVKGAFEFPANFYQDATNIKPNELGSLQLYHYHQQAWSETQGLDLF
The following text describes a protein:
Function:
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
Subcellular Localization:
Cytoplasm.
Sequence:
MDTRMDTAVTVEQLPPAVTLSVDAPSSETVTVGTELPEPTSENNITEIPENTPLDNVHPQSHEPSDPIPAPQPPQPELEHAYWAEIEEDTSVPDEAEMKEIESTADGDYSAYEYDYWEKNFHPDLDDPEYRPVEKGRLTWKIKGVRGTKDAPNRSKIMRSPPAYIGGYWWTIKFFPRGNNVGSLSIYIECSPTLPQPDKTLPETEFKVLRGPADSGLNNAAPELDMKFARTEDTASWLEQFTAQYPAAAASRQDPPKDTWRVSAQIGVILYNPDEPRTGWMQSSCHQFNPHNLDWGWTNFHGPWDQIHRRQRGQRQALLRNDTLAFDAYIRIIDDPTRSLWWHASDSEPTWDSLGLTGYRPLGDSVINHSAEVAGLASWLHLAPLCKIIQNAKVLDHYTNCDVKPKPLCDALQKFLWRLRSRGQSLQYVDTDIITSILRNLHEYSGDVCEFWERLRRTIEFELSDTDAPKELAKIFDSPSPDSLAVSGVDAVNTIPKDFNSRICVPAEQAKTMREGLSWYLTQKPGRWALPPVLHVELYRHKLDKAARQWRLVYNKVDLDEELDLTPYLVDGQCGSYVLYGYIVHRGRRTSGKFFSILRPGGPGTRWLAFDDGSDNRVECLTRKTALGPHLGLDESQKVDHKTGHDVAIAVMYIRGDVVSEFLPGPQGPWDVSPSLKEYYETGIYPLSSMSAGKPAEKEIQVEVYAPPQYDKLPSLFDSYDLMSQAKAANKVMYMTVPRSENIVELRKKIALWASAGSETQASPENIRLWQIGHTRDRFGPTLAFERISDLKSTLDLPVPVARLWMQVVSDDEAKYFAIRDPRDTVVAQRKTEEAVVERAGSESSDDRQYTPEVRSGGAEASSSGNVTESDFSNGDRVSVEQPPPRASDSEVSESSSQETPDSSEIQPSNASTEDDAAIAAIIAQDVQQMDIQLAEEAQQSPIRAEQSSNDTTQSEPAEQRAASPAPEAMSSTSEEPDVPLPVEHVYYFIQIFDVEAQALRTVGSFFSRKEEKIKTALRKHLKWPMTKDFSIWQRVDGTTVTTMSSVGTFDVYVPDGTCFIVGDKFSKEKRTELSVAGLFSSPDRLIHYLFAAERNHPTRAFTGTKTIDASFNSEYYSGEFLKGYYHGKGKHISDSAATYVGDFVFGKRHGSGAMEYPTGDTYDGDWYEDQCHGQGTFVEKKTGNKYVGGYKDGKRHGKGISYWEVADEEMDLCQICYSEEQDALFYDCGHVCACVTCARQVDICPICRKNIISVVKIYRT
The following text describes a protein:
Function:
This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis. ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically. It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Sequence:
MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPKKKAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFQYSKVRHLLKDLDELMDAVLERILAPEPSHANATEALNFTIWNHTPLVLIDEQNPHKPVVLDLFGDNHNSSASSSPAPGRTCDAQGCKVAMRLCSLNGTVCTFRNFTSATQAVMEWYVLQATNIFSQVPRQELVAMSYPGEQLILACLFGAEPCSHRNFTSIFHPDYGNCHIFNWGMTEKALPSSNPGAEFGLKLILDIGQEDYVPFLTSTAGARLLLHEQRSYPFIKEEGIYAMSGTETSIGVLVDRLERKGEPYSRCTKNGSDVPIPNLYSDHNTTYSIQACIHSCFQDHMIRNCSCGHYLYPLPRGEKYCNNQDFPDWAYCYSDLRINVAQRETCINLCKESCNDTQYKMTISMAEWPSEASEDWILHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITVIKLVAFSKSLQRRRAQAHYASPPPTVAELVEAHTNFGFQPDVISHSPTTGTYPDEQPVPIPGTPPPNYDSLRLQPLDVVESDNEGDAI
The following text describes a protein:
Function:
Participates in the control of the reentry into the cell cycle following pheromone treatment.
Miscellaneous:
MISCELLANEOUS: Present with 1540 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MNSGGSDSFDYLLQLTKALSAECRANRQETDRIELLLKRLAKQSGISYDNLSKNIIPDSWKDNASQKASPPTEAQKLISENFKLIYEIEKQEYFNTKAVALINNINEHFSYIKNFIDEQNAIRERNIATFSSEKLDERNKSLQQNYESLKTENEETKKKLHSIIKQFEKLLKEVDWDRISKDSRDYSRFKKQLEYLQDTYQVLK
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 1700 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MNSLIFGKQLAFHKIVPTTAIGWLVPLGNPSLQIPGQKQLGSIHRWLREKLQQDHKDTEDKDFFSNNGILLAVPKKKVSHQKKRQKLYGPGKKQLKMIHHLNKCPSCGHYKRANTLCMYCVGQISHIWKTHTAKEEIKPRQEEELSELDQRVLYPGRRDTKYTKDLKDKDNYLERRVRTLKKD
The following text describes a protein:
Function:
May be involved in the regulation of cell differentiation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MARCSNNLVGILNFLVFLLSIPILAGGIWLSQKGSTECERFLDKPVIALGVFLMVVAIAGLIGSCCRVTWLLWVYLFVMFLLILLVFCITVFAFVVTNKGAGEAIEGKGYKEYKLGDYSTWLQKRVENGKNWNKIRSCLVESKVCSKLEAKFVNVPVNSFYKEHLTALQSGCCKPSDECGFEYVNPTTWTKNTTGTHTNPDCQTWDNAKEKLCFDCQSCKAGLLDNVKSAWKKVAIVNIVFLVFLIIVYSVGCCAFRNNKRDDSYSRTYGYKP
The following text describes a protein:
Function:
Involved in the regulation of lipid metabolism and hypoxic response. Positively regulates transcription of various genes, such as phoP, groEL2 and dosR. Negatively regulates its own transcription. Acts by binding to a specific palindromic sequence motif in promoter regions.
Sequence:
MSTYRSPDRAWQALADGTRRAIVERLAHGPLAVGELARDLPVSRPAVSQHLKVLKTARLVCDRPAGTRRVYQLDPTGLAALRTDLDRFWTRALTGYAQLIDSEGDDT
The following text describes a protein:
Function:
Plays a role in nitrite reduction.
Subcellular Localization:
Periplasm.
Sequence:
MSVLRSLLTAGVLASGLLWSLNGITATPAAQASDDRYEVTQQRNPDAACLDCHKPDTEGMHGKHASVINPNNKLPVTCTNCHGQPSPQHREGVKDVMRFNEPMYKVGEQNSVCMSCHLPEQLQKAFWPHDVHVTKVACASCHSLHPQQDTMQTLSDKGRIKICVDCHSDQRTNPNFNPASVPLLKEQP
The following text describes a protein:
Function:
Leucine-rich repeat protein that likely mediates protein interactions, possibly in the context of signal transduction.
Sequence:
MGRAVETVEDVVAQMKLLLTAVPPRPSFGEVEAAKLAIRDEESSLSAKLDELFSEPCPPAVPPRVFRALQEMHESVIRTQSEVRRKSHAFVLQLEERHRIFDDLLRRAESALALALAPAPASKFAAPSPPSSLVAAASPLRRSSSGGPLSTIANERARPLQALLDPPSPPRPPPPAPATVAARPRYEPEAGGLLARTQQEGRSLFERGAKIEPVEPKTSAEPALAPSSGAADEELLGARWPPNLLSILETAEKDGQQPEALDFSNGGYTWIPESIGMLVNLTSLDLSGNMLSALPESIGLLTHLTSLDVEANLLKSLPESLGLLTCLQTLNIEKNSIEELPWTIGKCTALVELRADFNQLKALPEAVGQLRSLRILSVHLNCLKTLPTTMASLTSLTELYVHFNQLDTLPESICSLTSLQKLDASSNFSDFRSLPPSIGNLQGLRDLDLSFNHLSVLPDSFAQLTNLRRLKLDGNPWRSPPLEVVAEGQQAVLEYMAKWKERDLEEKAKES
The following text describes a protein:
Function:
Chaperone required for protein translocation and folding in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MKRSVLTIILFFSCQFWHAFASSVLAIDYGTEWTKAALIKPGIPLEIVLTKDTRRKEQSAVAFKGNERIFGVDASNLATRFPAHSIRNVKELLDTAGLESVLVQKYQSSYPAIQLVENEETTSGISFVISDEENYSLEEIIAMTMEHYISLAEEMAHEKITDLVLTVPPHFNELQRSILLEAARILNKHVLALIDDNVAVAIEYSLSRSFSTDPTYNIIYDSGSGSTSATVISFDTVEGSSLGKKQNITRIRALASGFTLKLSGNEINRKLIGFMKNSFYQKHGIDLSHNHRALARLEKEALRVKHILSANSEAIASIEELADGIDFRLKITRSVLESLCKDMEDAAVEPINKALKKANLTFSEINSIILFGGASRIPFIQSTLADYVSSDKISKNVNADEASVKGAAFYGASLTKSFRVKPLIVQDIINYPYLLSLGTSEYIVALPDSTPYGMQHNVTIHNVSTIGKHPSFPLSNNGELIGEFTLSNITDVEKVCACSNKNIQISFSSDRTKGILVPLSAIMTCEHGELSSKHKLGDRVKSLFGSHDESGLRNNESYPIGFTYKKYGEMSDNALRLASAKLERRLQIDKSKAAHDNALNELETLLYRAQAMVDDDEFLEFANPEETKILKNDSVESYDWLIEYGSQSPTSEVTDRYKKLDDTLKSISFRFDQAKQFNTSLENFKNALERAESLLTNFDVPDYPLNVYDEKDVKRVNSLRGTSYKKLGNQYYNDTQWLKDNLDSHLSHTLSEDPLIKVEELEEKAKRLQELTYEYLRRSLQQPKLKAKKGASSSSTAESKVEDETFTNDIEPTTALNSTSTQETEKSRASVTQRPSSLQQEIDDSDEL