lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MNQQVVSETTQTGTVVYTLRASPSGGATEPVKSDESGGLSNNVTNSSSSSLRFFIRGTEAFIVNEATGDVTLSQPLDRETTDSIKLTVGVSDESGASVEIPITVIVSDENDNPPTFSQASYDGSLSGAAILEEFIVNDADVVGEIIEVTCADNPAICDHVDIVSKLSSASLFRGSVVARKPLDPIELGTQLTFTLIANDGVHTSRAQVKILVPDASREESRPVYTGPLTGIVSEGDDIGTLVLTLAAEVVGGGNVTYQLVENTGDLFELDSTSGQLRTARAIDRESVALNGFLPVTIRVTARDGQSVEQVLNVIVVDVNDEPPRFNQNEYFALIHENLPSGTPLSGLNIVATDRDSNLNAMFELELIDSSGLFVVEPTSGVGSTNVGIRLAKGPLDYENPNQHKFILLIMARESQSKERLSSTCTVIVTVQDENDNPPVFERELYALSVSEEGSNETEIGTVAATDRDSGLYGQKGFKYELLFGDQRTNETLFNVDPSTGQIRVSDCPTPGRAPCLDYEARSAYFLILRVTDDEGRGNSALVPLRIDLRDVNDNPPLFELLVFHASIDEGATKFDPPFKVRARDEDSISVLTYSIIDGDPTKMFFMDAKTGEVRVNKPIEVNSSQVTTEEFNLNILVSDGTKTDTATLKISIRDVNNHKPTFLQAIYNVSISELLIPGSNVTQVSAKDADFGENARLNYKIERASYNKFQIDPETGVIKVTQPLNFDRQSTYSLQVVAVDNGWPALTGSAAVLVNVEDKNNHPPKFVPISQHAQATETAKLNTIIHTLSAVDRDALPGSLRYSLVEPITAVDRDGRDVKTNSMFKSFFGVNDRSGDIFVKDNLDRGVAAVVTMTTLVTDTSADPPVQQQSKGLITITILDVNEHPPTFSKPRNSEEPFINLLVAEEQPIGSIVGKISATDPDSPIDRYEFLPPHPFFSIDGRSGVVTNKQRLDYEASPEYNLTVVAHDAGIPSLSSMAQVKVTLININDLSPAFTSKSYESRIPEHSAAGTAVLTVSATDGDAGSFGLITYSLTGENAKYFTIDASGTITVTDPGGLDRERSPSLTLLVAASDLAPPGARRTTIMPVEIQLEDINDNQPKFLDNTYRATVAETVPLLPPPPIVQITAIDHDSGMNSALRYTIIEGNEDGLFTLDSATGILYPALSLTNRSREYTLSVEVRDLNGTGTNFDRATVKINVQSVNQNKPRFIVPSLANATIRIPENSKDEDHLVLVLKAEDTDAGDNGRVTYHIRVGEQLVKETPEFQLDPNSGELRTRLKLDREAQSSFELLLVAKDQGGPTTSYETLRLLTVMVEDENDNQPEFPVERRSKVAPYHFRIEENVRPDTAVGQVQAFDADTGPNAKIYYHILAGNEGNWFYIDRTHGFVYNRVVLDREIRHTYDLLVKATNDHQYLTTQMSDAEREKRQAMDHDPSIAQVHIDVVDINDNPPHFERETFTLFTESLMAEYNQDRFVLEVVAREEAPPFREDTANVHLWVYESNQLSMIVVAKPLERALIERELLGDELRNATQLLIVIDEMRHHVEDDGSLNKNKTDVYVHGVDRGGNKTIAPVSEVLRAIDLHYDVLRSFNDTAIVNVVSATAAPRKALLEPAIMALIALLVVLFVGFVMVIFTCCCIRNWDIVATNNQHESNNKSGTSTVNRDRMLSTMHRPHPASVSHSPSELLNSTENPLWIDKYVKPYEEQELSMRVAPDLESPVRMGGASNNASGADQANPYATIQKPRRALPSIHLGEEVGESSDYATIGGSPNNKYPTSRDTQIILASGSSTPHLMMNQNGEPILVADLI
The following text describes a protein:
Function:
Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (By similarity). In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (By similarity).
Subcellular Localization:
Endoplasmic reticulum. Secreted.
Sequence:
MATTWGAAFFMLVASCVCSTVFHRDQQTWFEGVFLSSMCPINVSASTLYGIMFDAGSTGTRIHIYTFVQKIPGQLPILEGEIFESVKPGLSAFVDQPKQGAETVEELLEVAKDSVPRSHWKRTPVVLKATAGLRLLPEQKAEALLFEVREIFRKSPFLVPDDSVSIMDGSYEGILAWVTVNFLTGQLHGHSQKTVGTLDLGGASTQITFLPQFEKTLEQTPRGYLTSFEMFNSTYKLYTHSYLGFGLKAARLATLGALETEGIDGHTFRSACLPRWLEAEWIFGGVKYQYGGNKEGNEGSGEVGFEPCYAEVLRVVQGKLHQPDEVRKSSFYAFSYYYDRAADTDMIDYETGGVLKVEDFERKAREVCDNLEKFTSGSPFLCMDLSYITALLKDGFGFADSTILQLSKKVNNIETGWALGATFHLLQSLGISH
The following text describes a protein:
Function:
Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.
Sequence:
MPKIILVSHSKEIASGTKSLLKQMAGDVDIIPIGGLPDGSIGTSFDIIQEVLTKLEDDALCFYDIGSSEMNVDMAIEMYDGNHRVLKVDAPIVEGSFIAAVKLSIGGSIDDALAEIKQSF
The following text describes a protein:
Function:
SOSEKI proteins locally interpret global polarity cues and can influence cell division orientation to coordinate cell polarization relative to body axes.
Miscellaneous:
MISCELLANEOUS: 'Soseki' means cornerstone in Japanese.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The DIX-like oligomerization domain is required for polymerization, edge localization and biological activity.
Sequence:
MDSSSESYHKIEVIYLLSKGAEQDDHPHMIQVQYPSHQHAPTLRDVKFRLTALRGRGMPDSYSWSYKRSYKGTFIWCDVFDGDDILPLSESGEYVLKALEVMDSSEDACDRGVEHLGQEVARVLPTNRNGTSANFNEVHSIDDVRRVAPNKCVEVKRQFMGGSVHNNMTGKANRNEQGDAYGTTSRVPDPENCIENKRCLESMTGSDSSRSNISTDESYGLSFERDLKMDMKEMPACPATRSTDHGGMSSLAPRSSRLSRREYVKCKTWAVKEDENAALNHGRLSRRSSDTLRDSNSVGNTVDIPSSPVTRPCFPGDPLIFMLKKATKFHRSQLCRKAEVEGSPCATVGKPSSSRHTSKIRHGSGPLKAYHGPHSSKSATQNSRPVTYETSAKESERDIRSLCQFLGASNVGSVSQTINKEGTKKTGSARHIQAGSNDDFDFARHKEVAVDISEKLLLPEQVTGRYEKPSRMSKQLINKLDSKSLNMVTRPAVRLSSKLGSGQASESFSPASPHAPQRPIVSRPQEKAVNQLSLVAGFEDPQITSSDTSNAGLSCTSKASGLKAVKLPRNASNNCYFSLTIPDLEKRAADTKVYPWRENSAFNSIELYSGTLQKVDLAINTSFNGATLGELASGGC
The following text describes a protein:
Function:
Endoribonuclease that cleaves tRNAs and rRNAs. Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem. May be involved in immune system via regulation of inflammation.
Subcellular Localization:
Cytoplasm.
Domain:
Shows a pseudo-dimeric U-pillow-shaped architecture of the SLFN13 N'-domain that may clamp base-paired RNAs.
Sequence:
METHPSLAVKWSCPDLTIYAGEVTIGEEDRNKMDSKKRKLEKTRITEAACALLNSGGGLIAMQMTNKSEHPVEMGQDLEKSLRELIMSPNMQAFFETKQQEDQFYIFVKSWSCRPEDGSTKPRICSLGSSLYCRSITSKVAMDSREAFEFLKDKKACIKYRPTDDGAPPAKIPRAMCQNSLESNPAFEIFQSKKLEYGQCLLFSESTSIEFKQFSTKHVQAYMKNIIPEYISAFANTQGGYLFIGVDDKRIILGCPKDNVDRDSLKTVANETISKVPVFHFCSSKDKDKVSYETRVIDVFQEGNLYGYLCVIKVEPFCCAVFSEAPISWMVDKEKGVYRLNTEEWVRMMVDFGPEASSKDLSKDFECQLSLCNSPPHCRPVYSKKGLQHKVDLQQRLFQVSPDCLKYTPESLWKELCSQHKRLKGLVKQQIRSFSCGLLILYRSWAVDLNLKEKQEVICDALLIAQNSPPILYTILGEQDEQGQDYCNHTAFTLKQKLVNTGGYTGRVCVMTKVLCLSSQNNIETNGGSVSPINYPSSYNLANIQEMQDLLQALVIVLLNFRSFLSDQLGCEILNLLTAQQYEILSKSLRKTRELFVHGLPGSGKTIIAMKIMEKIRNTFHCETDSILYICENQPLRDFIRAKRICQAVTRKTFMNYRFKTNSFQHIIVDEAQNFRTEDGNWYGKAKAISRRVKSCPGMFWIFLDYFQTSHLKESGLPDFSRQYPREELTQVVRNGDKIAEFLQKELQKIRDNPPCSIPRQSLNIVHEFKWSQSVSGNIKTEQFTLEDMVIYVADKCYDFLRKGYSLQDIAVLFSTDKEKKTYESMFLGEMRKRRRASEMNHAYLCDSNMFDSIRRFSGLERSIVFGINPIATEQPISHNLLLCLASRAMKHLYILYFSTPEGHSSTEAC
The following text describes a protein:
Function:
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies (By similarity).
Subcellular Localization:
Nucleus, nucleoplasm. Cytoplasm, P-body.
Sequence:
MSHVDVTVDEATINAIRQRMLETGDWERIQKLLRAHLEESGWVDDLKDLAKEKARAQDVPNLENLVKQISESAAGMVSDNVKRDVMLEIESVLDREVDQA
The following text describes a protein:
Function:
Hydrogen and organic peroxide sensor. Represses the expression of a regulon of peroxide-inducible genes such as katA, ahpC, ahpF, the heme biosynthesis operon (hemAXCDBL), fur, perR, zosA and mrgA.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIYKALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKIVDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH
The following text describes a protein:
Function:
Induces gamma-tubulin accumulation at cell-cell junctions and may direct the assembly of robust microtubule arrays during cell elongation. May regulate the surface expression of amiloride-sensitive sodium channel.
Subcellular Localization:
Apicolateral cell membrane. Apical cell membrane. Cytoplasm, cytoskeleton.
Domain:
The ASD1 domain mediates F-actin binding.
Sequence:
MSAFGNTIERWNIKSTGVIAGLGHSERISPVRSMTTLVDSAYSSFSGSSYVPEYQNSFQHDGCHYNDEQLSYMDSEYVRAIYNPSLLDKDGVYNDIVSEHGSSKVALSGRSSSSLCSDNTTSVHRTSPAKLDNYVTNLDSEKNIYGDPINMKHKQNRPNHKAYGLQRNSPTGINSLQEKENQLYNPSNFMEIKDNYFGRSLDVLQADGDIMTQDSYTQNALYFPQNQPDQYRNTQYPGANRMSKEQFKVNDVQKSNEENTERDGPYLTKDGQFVQGQYASDVRTSFKNIRRSLKKSASGKIVAHDSQGSCWIMKPGKDTPSFNSEGTITDMDYDNREQWDIRKSRLSTRASQSLYYESNEDVSGPPLKAMNSKNEVDQTLSFQKDATVKSIPLLSQQLQQEKCKSHPLSDLNCEKITKASTPMLYHLAGGRHSAFIAPVHNTNPAQQEKLKLESKTLERMNNISVLQLSEPRPDNHKLPKNKSLTQLADLHDSVEGGNSGNLNSSAEESLMNDYIEKLKVAQKKVLRETSFKRKDLQMSLPCRFKLNPPKRPTIDHFRSYSSSSANEESAYLQTKNSADSSYKKDDTEKVAVTRIGGRKRITKEQKKLCYSEPEKLDHLGIQKSNFAWKEEPTFANRREMSDSDISANRIKYLESKERTNSSSNLSKTELKQIQHNALVQYMERKTNQRPNSNPQVQMERTSLGLPNYNEWSIYSSETSSSDASQKYLRRRSAGASSSYDATVTWNDRFGKTSPLGRSAAEKTAGVQRKTFSDQRTLDGSQEHLEGSSPSLSQKTSKSTHNEQVSYVNMEFLPSSHSKNHMYNDRLTVPGDGTSAESGRMFVSKSRGKSMEEIGTTDIVKLAELSHSSDQLYHIKGPVISSRLENTRTTAASHQDRLLASTQIETGNLPRQTHQESVVGPCRSDLANLGQEAHSWPLRASDVSPGTDNPCSSSPSAEVQPGAPEPLHCLQTEDEVFTPASTARNEEPNSTAFSYLLSTGKPVSQGEATALSFTFLPEQDRLEHPIVSETTPSSESDENVSDAAAEKETTTTQLPETSNVNKPLGFTVDNQEVEGDGEPMQPEFIDSSKQLELSSLPSSQVNIMQTAEPYLGDKNIGNEQKTEDLEQKSKNPEEDDLPKVKLKSPEDEILEELVKEIVAKDKSLLNCLQPVSVRESAMDLMKSLFPMDVTAAEKSRTRGLLGKDKGETLKKNNSDLESSSKLPSKITGMLQKRPDGESLDDITLKKMELLSKIGSKLEDLCEQREFLLSDISKNTTNGNNMQTMVKELCKPNEFERYMMFIGDLEKVVSLLFSLSTRLTRVENSLSKVDENTDAEEMQSLKERHNLLSSQREDAKDLKANLDRREQVVTGILVKYLNEEQLQDYKHFVRLKTSLLIEQKNLEEKIKVYEEQFESIHNSLPP
The following text describes a protein:
Function:
May play a role in the regulation of metabolism and signal transduction processes.
Sequence:
MTSKTMPQTIPAIPNIEEKKQYSQTDSSLNLTSSSKSSTALPRKLPESAILGSPDKEIQSSDQKPSHKLHESIDVTSSKEVPADDEKDTLENGNTDGNMKSDSVVDKDHGATTSASGSARLTGRSETGERGISSRCRPSTGSDVSEESACSSFSSTSKPHKANDSRWEAIQMIRTRDGILGLSHFKLLKKLGCGDIGSVYLSELTGTKSYFAMKVMDKASLTGRKKLLRAQTEKEILQCLDHPFLPTLYTHFETDKFSCLVMEFCPGGDLHTLRQKQRGKYFPEQAVKFYVAEILLAMEYLHMLGIIYRDLKPENILVRDDGHIMLSDFDLSLRCTVSPTLIRSSNPETEALRKSSQAYCAQPVCAEPSCMIQPSCTAPTTCFGPRFFSKSKKDRKPKPEVVNQVRPWPELMAEPSDARSMSFVGTHEYLAPEIIKGEGHGSAVDWWTFGIFLYELLFGKTPFKGSGNRATLFNVIGQPLRFPEYPVVSFSARDLIRGLLVKEPQQRLGCKRGATEIKQHPFFEGVNWALIRCASPPEVPKPVDIERQTTKLPVSTSEASAAPTGASQKGSDNYLEFDFF
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Sequence:
MTSYQKELPVDCFEHVLPDEYNTRKIPRAEYIEDIADFVRQHGDDAAAAIAALQEKLQKYSFMLDVVQKQKNSLVGSTADLRENLDLIDYLEKQESAFEARYELAAGVYAKAMIPKSDQVSLWLGSHVMVEFPHGEARSLLKKNLGDAEQSIAEMAKNLQFIKEQITMIEVSISRVFNWDVQRVKTSGDIIE
The following text describes a protein:
Function:
Hormone which may be vasoactive and natriuretic. Has a cGMP-stimulating activity (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MSGQTSFYCGLLLVLLIQAQARPRSDDSLQTLSRLLEDEYGHYLPSDELNNEAQEMSPAASLPEFNADQSDLELPWDRESREIGGRPFRQEAVLARLLKDLSNNPLRFRGRSKKGPSRGCFGVKLDRIGAMSGLGC
The following text describes a protein:
Function:
Mediates cation-selective currents but does not discriminate between different monovalent cations.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
APADNAADARPVDVSVSIFINKIYGVNTLEQTYKVDGYIVAQWTGKPRKTPGDKPLIVENTQIERWINNGLWVPALEFINVVGSPDTGNKRLMLFPDGRVIYNARFLGSFSNDMDFRLFPFDRQQFVLELEPFSYNNQQLRFSDIQVYTENIDNEEIDEWWIRKASTHISDIRYDHLSSVQPNQNEFSRITVRIDAVRNPSYYLWSFILPLGLIIAASWSVFWLESFSERLQTSFTLMLTVVAYAFYTSNILPRLPYTTVIDQMIIAGYGSIFAAILLIIFAHHRQAMGVEDDLLIQRCRLAFPLGFLAIGCVLVIRGITL
The following text describes a protein:
Function:
Required for pre-mRNA splicing as component of the activated spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).
Subcellular Localization:
Nucleus. Nucleus, nucleolus.
Sequence:
MAGTGLVAGEVVVDALPYFDQGYEAPGVREAAAALVEEETRRYRPTKNYLSYLTAPDYSAFETDIMRNEFERLAARQPIELLSMKRYELPAPPSGQKKNDITAWQECVNNSMAQLEHQAVRIENLELMSQHGCNAWKVYNENLVHMIEHAQKELQKLRKHIQDLNWQRKNMQLTAGSKLREMESNWVSLVSKNYEIERTIVQLENEIYQIKQQHGEANKENIRQDF
The following text describes a protein:
Function:
Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MGPRARPALLLLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFVFYDHESRRVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFWTIMENHNHSKESHTLQVILGCEMQEDNSTEGYWKYGYDGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHKIRARQNRAYLERDCPAQLQQLLELGRGVLDQQEGSESSSLPGKVTTLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIWEPSPSGTLVIGVISGIAVFVVILFIGILFIILRKRQGSRGAMGHYVLAERE
The following text describes a protein:
Function:
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MSDSGAKGNQSLSQKDKDGTEKRGRGRPRKQPQLKSLEEPSGSPSPKRPRGRPKGSKNKTTGKSKKSTASAGGKRRGRPKKAEKEEEQGSQESSEEEEEQ
The following text describes a protein:
Function:
Solute carrier protein that negatively regulates the cytosolic homeostasis in response to high levels of extracellular calcium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Bud neck. Note=Distributes as multiple foci in the plasma membrane prior to cell division, moves toward and concentrates at the bud neck as the bud grows in size, and disperses again along the plasma membrane immediately prior to cytokinesis.
Sequence:
MSLETFRESKAYKWTSKVISFLIGQWFFIFLGVFIALAHSYPEFAKQGGTIRAEYSIGYGAVAVIFLISGLSMSTKQLLVNVANWRAHFTVLSMSFLVTSAIIYGIASGIKASHNGQIDDWLLIGLIVTHACPTTVSSNVVMTKQAHGNDILTLCEVFIGNVLGAFITPALLQMYMRGTWEIGNPSHQTQGDSTVQELYAHTMKQLGLSVFVPLFVGQVVQNIFPKQTKWCLTTFKLNKVGSFMLLLIMFQSFSTAFAQHAFTSVSHASIIFLVFFNIGIYLFFTVLTFFYSRPFWILRVFKEEPNESSSKLYRYSYAFFRPFYYNRKDTVAVMLCGPAKTAALGVSLVSSQYGSHNPKLGIILVPLVLYQAEQVMTANVLVSFMRKWIHAEDKVPEDEETSVGSDNDPKK
The following text describes a protein:
Function:
May act as a GTPase-activating protein for Rab family protein(s).
Sequence:
MSSDGNKKQFWKRNTAKVPGNIQHVYGAQHPPFDPLLHANLMKAGNKPPSASTPGKPKKATTFQEFESITSDAWDVGDDDDELLAMAAQNLNIEVVMETANKVIENHSKLQERRQQEMEKTTEPDEKYGEEVEEEEEEPEEEEEREEVVETTDVSFSTDPLPLGDSRLVKSHSEAPIGSPKEVGIKQAALHRQQSLPHRPVIPLVARMADQNTSGTPAMTEREASRLDKFRQVLAGPNTDLEELRKLSWSGIPRQVRPITWKLLSGYLPANAERRESTLQRKRQEYFGFIEQYYDSRNDEHHQDTYRQIHIDIPRMSPESLVLQPKVTEIHIDIPRTNPLIPLFQQASVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVYVFEYIEEEVENFNVSSLQEEVLRNIEADSFWCMSKLLDGIQDNYTFAQPGIQRKVKALEELVSRIDETVHRHMQLYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQAEPEGFSHFHLYVCAAFLVRWRKEILEEKDFQGLMILLQNLPTMHWGNEEVSVLLAEAYRLKFAFADAPNHYKR
The following text describes a protein:
Function:
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
Subcellular Localization:
Nucleus.
Sequence:
MTSSSKKKKEKKKDFQKVKLKVGKGRPKAANSTDTSFKAKCRYINSRSIEPFLIFKAIALKQQSLSTVAPTLEAQCAHHLGLLNHKSDAQRRESLAYLTTAIVNNPPMAPLPQPASVIIPVAQRLILDGTNSVRQQLLKLLHSLPPADIASHADQLLLHTRAAMTHLANEIRTFGLDVLDWLLGVAGDEVVSCAGGWVKMLKCFLSLLGWQSEATSKWSAPKAFGKADSKMQARQMSALTTFLRTGLFHAQAATPVVVVGNSFPLWQTEHHRLSERSNAYAHLNLFGATRDEEAEMYEDREDRQRIFHDRAETAVVAGLEQATKAGGELGRAAAQLRKVVKDGMADFYREEVMVP
The following text describes a protein:
Function:
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSLARGISRRRTEVATQVEAAPTGLRPNAVVGVRLAALADQVGAALAEGPAQRAVTEDRTVTGVTLRAQDVSPGDLFAALTGSTTHGARHVGDAIARGAVAVLTDPAGVAEIAGRAAVPVLVHPAPRGVLGGLAATVYGHPSERLTVIGITGTSGKTTTTYLVEAGLRAAGRVAGLIGTIGIRVGGADLPSALTTPEAPTLQAMLAAMVERGVDTVVMEVSSHALALGRVDGTRFAVGAFTNLSRDHLDFHPSMADYFEAKASLFDPDSALRARTAVVCIDDDAGRAMAARAADAITVSAADRPAHWRATDVAPTDAGGQQFTAIDPAGVGHHIGIRLPGRYNVANCLVALAILDTVGVSPEQAVPGLREIRVPGRLEQIDRGQGFLALVDYAHKPEALRSVLTTLAHPDRRLAVVFGAGGDRDPGKRAPMGRIAAQLADLVVVTDDNPRDEDPTAIRREILAGAAEVGGDAQVVEIADRRDAIRHAVAWARPGDVVLIAGKGHETGQRGGGRVRPFDDRVELAAALEALERRA
The following text describes a protein:
Function:
Could be the regulator of the abg operon.
Sequence:
MAFQVKIHQIRAFVEVARQGSIRGASRMLNMSQPALSKSIQELEEGLAAQLFFRRSKGVTLTDAGESFYQHASLILEELRAAQEDIRQRQGQLAGQINIGMGASISRSLMPAVISRFHQQHPQVKVRIMEGQLVSMINELRQGELDFTINTYYQGPYDHEFTFEKLLEKQFAIFCRPGHPAIGARSIKQLLDYSWTMPTPHGSYYKQLSELLDDQAQTPQVGVVCETFSACISLVAKSDFLSKLPEEMGCDPLHGQGLVMLPVSEILPKAAYYLIQRRDSRQTPLTASLITQFRRECGYLQS
The following text describes a protein:
Function:
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSLKPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFKLLTKDAKAVIRTGEFTPYANCILQAGVLF
The following text describes a protein:
Function:
Involved in the biosynthesis of D-psicose. Catalyzes the reversible epimerization of D-fructose at the C3 position to yield D-psicose. The enzyme is highly specific for D-psicose and shows very low activity with D-tagatose. The substrate specificity decreases in the following order: D-fructose, D-tagatose, D-ribulose, D-xylulose, and D-sorbose. It shows a higher level of activity for cis ketoses than for trans-ketoses.
Sequence:
MKHGIYYSYWEHEWSAKFGPYIEKVAKLGFDIIEVAAHHINEYSDAELATIRKSAKDNGIILTAGIGPSKTKNLSSEDAAVRAAGKAFFERTLSNVAKLDIHTIGGALHSYWPIDYSQPVDKAGDYARGVEGINGIADFANDLGINLCIEVLNRFENHVLNTAAEGVAFVKDVGKNNVKVMLDTFHMNIEEDSFGDAIRTAGPLLGHFHTGESNRRVPGKGRMPWHEIGLALRDINYTGAVIMEPFVKTGGTIGSDIKVWRDLSGGADIAKMDEDARNALAFSRFVLGG
The following text describes a protein:
Function:
Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.
Subcellular Localization:
Cytoplasm. Nucleus speckle. Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
REGRSLGPAPTPAARAPPRSSARCLQPEQQGVRDPGGIWVKLGAAEASAERLQGRRSRGASGSEPQQMGSDVRDLNALLPAVPSLGGGGGCALPVSGAAQWAPVLDFAPPGASAYGSLGGPAPPPAPPPPPPPPPHSFIKQEPSWGGAEPHEEQCLSAFTVHFSGQFTGTAGACRYGPFGPPPPSQASSGQARMFPNAPYLPSCLESQPAIRNQGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHGTGYESDNHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGKTSEKPFSCRWPSCQKKFARSDELVRHHNMHQRNMTKLQLAL
The following text describes a protein:
Function:
Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.
Sequence:
MFFPMVPMSAPPSFTALAQAVNQPKIGFDSQNPPPQAVLDSCVHCGFCLNTCPSYRVIGKETDSPRGRIYLMNGINQGQASLDATTIQHFDSCLGCLACVSACPSGVQYDQLISATRPQVERNHDRPFGDRLLRGIIFNLFPYPWRLRLLLPLLWVYQNCGLQKLVQATGLLSRFFPRLAAMESILPRVTAASFRDNYPTEISAQGEKRYRVGIILGCVQRLFFSPVNEATVRVLTANGCEVVIPQSQGCCAALPAHQGQTDQAEAIARQMIDSFANTEVDYIIINAAGCGHTLKEYHHILADDAEYLPKAQAFVSKVRDINEFLMEIGLNQTLHPVTEELTPVVYQDACHLIHGQKISLQPRQLIAQIPHLQLREPLDAALCCGSAGVYNMLQPAVAEELGQQKVNNLCQTGAQLIISANPGCSLQIQKHLGKQGQNLGVIHPIQLLDLSLRGEKLTGL
The following text describes a protein:
Function:
Key transcription factors critical for hypoxia adaptation and virulence. Plays a major role in regulation of heme biosynthesis and carbohydrate metabolism early in the response to hypoxia.
Subcellular Localization:
Nucleus.
Sequence:
MAYNNRPDASTAFTFDNDDRFVNQQPKGPDPLSANWSYDSAIDLFSLNTMLPETFPLDIPNDMLLDPKDFPTDLFAPPADISGFAISHSGEDSLSSDQESEDQPWSPAYRVSSLDSTTPDAPTVSPRSTEKPATRRRTTTQKREQATRWSSSPEMTPQEYPVTSQATTSPAPAPVSPPAASTSRKNSRSLSTDSQTATGRNAAKRAAHNIIEKRYRTNMNAKFVALEKAMSGSGVQKPTKGGSGPASLKKSEILTNAIAYMQELQDQNAALQKELALLKQNLLPGGLWRHNKENDKFRT
The following text describes a protein:
Function:
Probable substrate recognition component of a CBC (Cul2-ElonginB-ElonginC) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ensures germline precursor cell asymmetry by targeting germline proteins for destruction if expressed in non-germline cells. This process also requires elc-1, cul-2, rbx-1 and ubc-2.
Sequence:
MSECSASTSQLSTFCVNEIPWKLVPQTCDEFSEYEFIDEKYRRLSDVESFVWKWSPCGRYGIDLPGGRDVINQQLRDRMAVFDLHTNKWTLYTMDRGAFEIPRVCFLYWARNDIIGTITLVKDYEAGPDDEIPLKFKQSFFYVSHETQTLVYSGSCKYRTNKTIVASYWYHIFENRRGEPFIDHNNYLWLVFSNGVDSLILLPFIPTSTCFKAKCVSFDMNDIVSQFTGIRVFLDPFVSSHYVPWVYRNDVNFFIRIDSHSFIEEQNRDYGLDPQIDNPETKPHRGVFQLRVNLKDVIEKGEKDAIHAVNPETIETRFNRGDIELWRKISDELRQEHQSIAQHGKMVVVQRWSHFTVDMGLSKKMRTRVADLDARDYCCSHKPRNSSFCCIDLDSERIKAVDALILGTDVVLPHPSGSVFLFRYKENYGMSYCELPFFQPLSLKLKCIQVLKESVEIDPSYYRIKCCLKMQEELEKETAENLCTINIQQ
The following text describes a protein:
Function:
Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.
Miscellaneous:
MISCELLANEOUS: In rat, the p62 complex contains two different isoforms of NUP58. Isoform p45 has however not been isolated in human so far.
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter.
Domain:
Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.
Sequence:
MSTGFSFGSGTLGSTTVAAGGTSTGGVFSFGTGASSNPSVGLNFGNLGSTSTPATTSAPSSGFGTGLFGSKPATGFTLGGTNTGIATTITTGLTLGTPATTSAATTGFSLGFNKPAASATPFALPITSTSASGLTLSSALTSTPAASTGFTLNNLGGTTATTTTASTGLSLGGALAGLGGSLFQSTNTGTSGLGQNALGLTLGTTAATSTAGNEGLGGIDFSSSSDKKSDKTGTRPEDSKALKDENLPPVICQDVENLQKFVKEQKQVQEEISRMSSKAMLKVQEDIKALKQLLSLAANGIQRNTLNIDKLKIETAQELKNAEIALRTQKTPPGLQHEYAAPADYFRILVQQFEVQLQQYRQQIEELENHLATQANNSHITPQDLSMAMQKIYQTFVALAAQLQSIHENVKVLKEQYLGYRKMFLGDAVDVFETRRAEAKKWQNTPRVTTGPTPFSTMPNAAAVAMAATLTQQQQPATGPQPSLGVSFGTPFGSGIGTGLQSSGLGSSNLGGFGTSSGFGCSTTGASTFGFGTTNKPSGSLSAGFGSSSTSGFNFSNPGITASAGLTFGVSNPASAGFGTGGQLLQLKKPPAGNKRGKR
The following text describes a protein:
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Sequence:
MFRPAYLRRLPTLKASTRLISTSLKSNQPLATNNPPAPLSKADVPQTMQQLGNLPGGSPVTGPGHHNLSTLSPSPFGGDIASAEDRSSDSHEARLLPENHPPMYLSSMKTSDVVALMLTSAATSHPTLIKLCTKLMPYTPNALIKAIVYSLYCGGANHAEVVETGKKLLDRGFGNMMLSYSVEDAEGGDSANALMDSAVDSIIESIDNVLVKYAHESEKKTGKSITGFVALKPTGLMKNATAILRNHDKPEYAEQWKQYLAVCRKICRHAAENGEGKVGIVFDAEKKVLQPGVYAAQRAMMQEFNVNGAVPVIGTIQMYLQDSIIQLQDDISHAAANGYQIGMKLVRGAYIHSEPDRWTTIHRTKEDSDISYNRGVALCLDGIIPDIQSGTHHSAVGKLIVASHNECSMALAAHRLSADLTPEQLESQDKVIFAQLMGMAEDLGEELAHRGYKVLKYVPWGPVNETKDYLVRRMEENGDTLSDGGMTVAFQCATELAKRLVK