lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. In the RAG complex, rag2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1. It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3 (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The atypical PHD-type zinc finger recognizes and binds histone H3 trimethylated on 'Lys-4' (H3K4me3). The atypical PHD-type zinc finger also binds various phosphoinositides (By similarity).
Sequence:
MSLQPLTAVNCGSLLQPGCSLLQLDGDIFLFGQKGWPRRSCPTGVFGVRLKHGELKLRPISSSNDSCYLPPLRCPALTRLEPHDGHPEGYLIHGGRTPNNEISSSLYLLTLDSRGCNRKVTLRCQERELVGEQPGPRYGHTLSMVQSLGKRACVVFGGRSYMPAGERTTENWNSVVDCPPQVFIIDLEFGCCSAHTLPELTDGQSFHLALARDDYVYFLGGQSLSLDFRPPRVYSLRDGVPEGKPAVSCSTWTPSMSISSAIATRVGPSHEFIILGGYQLETQKRMECSSVVLDDSGINIEPREAPEWTGEIKHNHTWFGGSMGGGSALIGIPSEGRQATPEAHYFYQVCFQKEGEGKGEDGNQVCSQESTDFEDSAPLEDSEELYFGREPHELEDSSEGEGDTYNEEDEEDESQTGYWVKCCLGCQVDPNTWEPYYSTELLRPAMIYCSKGEGGHWVHAQCMELTEGLLVRLSQGNGKYFCLDHGGLPRQEMTPPRQVLSLKRSPMKPQHRKGPMMRRMTPAKKRFFRRLFE
The following text describes a protein:
Function:
May bind chitin or related oligosaccharide structures.
Sequence:
MIIKTLLASVAIMLIATVNAEYNVAKYCELVKIGTLMPSMISCQDYYICRLNNQPIPVKCGANTVFDKDTQGCVPEAQANCILSLDNPCENKDRTFAPSSKACNEWHYCLNGNIVANGSCQPGQIFDASKNSCIYGACNSDDDDSNSDFTPVLNICDIMQNGQFFGDFENCQNWQKCNNGRLQKGICLGNLVYDTKNGMCLQNDGTMCERTNGMVSEDGGAPDETLCTSSNDGPLPDKLTCSVYYICEQDTTSTPTTYKWIKTSCPNGQYFDVFGDGCLDRAKRRVYTGCNRCEYTTGSTTYWVNAVSNDCTKFSTCRNGRKITNEDGSCNSGYYFNEADQYCNMGDFTNYAETNGACQNYSCNGYDCTTKPSAT
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Involved in the integration of spacer DNA into the CRISPR cassette (By similarity). Functions as a dsDNA-specific endonuclease, acting on circular and linear DNA; has no activity on ssRNA or ssDNA.
Sequence:
MLVLITYDVQTSSMGGTKRLRKVAKACQNYGQRVQNSVFECIVDSTQLTSLKLELTSLIDEEKDSLRIYRLGNNYKTKVEHIGAKPSIDLEDPLIF
The following text describes a protein:
Function:
Catalyzes the last step of the phosphorylated serine biosynthetic pathway, i.e. dephosphorylation of O-phospho-L-serine to form L-serine. Is also able to dephosphorylate O-phospho-D-serine with similar efficiency. Displays a poor activity on L-phosphothreonine, and cannot use L-phosphotyrosine, pyridoxal phosphate, glucose 6-phosphate, or fructose 6-phosphate as substrates.
Sequence:
MKLLLLDLDDTLLQDLPVSRAVLEDLGRKAGVEGFFARVKARAEALFREAPFYPWAEAIGHSALEALWARYSTPGLEALAAWAGPFRERVFREALEEAGGAPERARELAEAFFRERRRYPLYPEAEAFLAEARRRGLALALLTNGVPDLQREKLVGAGLAHHFSLVLISGEVGIGKPDPRLFRMALCAFGVAPEEAAMVGDNPQKDVRGARLAGVRAVWVDRGLRPEDPEASPDLRVGDLREVFLAEAL
The following text describes a protein:
Function:
Positively regulates the expression of at least groEL2. Cyclic AMP does not affect transcription in vitro.
Sequence:
MADRSVRPLRHLVHAVTGGQPPSEAQVRQAAWIARCVGRGGSAPLHRDDVSALAETLQVKEFAPGAVVFHADQTADGVWIVRHGLIELAVGSRRRRAVVNILHPGDVDGDIPLLLEMPMVYTGRALTQATCLFLDRQAFERLLATHPAIARRWLSSVAQRVSTAQIRLMGMLGRPLPAQVAQLLLDEAIDARIELAQRTLAAMLGAQRPSINKILKEFERDRLITVGYAVIEITDQHGLRARAQ
The following text describes a protein:
Function:
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MDQEACLDLDDDAMDLDDVDPTAPAMSAAAYFRQVKAERRQTADVVRIQNSQQNAPESTKKKQQQWLESVGFQKEDGAKNETSSLVPSVEWRAEKCRQFGDFREILAEKIAKTQPMKIKQLAAPSDDEWHEILLEKCLPEFQETCGNFKNHTGTPPSVLMVLAIPKRHLSQLIENLVEWSSEEGLSRPIREWIYALLLVIDLPLVQDVIAALRTLAKDCRKLRSRLPADRKAEANEYSMFIAIIGTFFGQKDLADI
The following text describes a protein:
Function:
Part of the ABC transporter complex GlcSTUV involved in glucose uptake (Probable). Responsible for energy coupling to the transport system. In vitro, as a free subunit, exhibits a constitutive ATPase activity.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Domain:
Consists of a typical ABC-ATPase domain, comprising two subdomains, connected by a linker region to a C-terminal domain of unknown function.
Sequence:
MVRIIVKNVSKVFKKGKVVALDNVNINIENGERFGILGPSGAGKTTFMRIIAGLDVPSTGELYFDDRLVASNGKLIVPPEDRKIGMVFQTWALYPNLTAFENIAFPLTNMKMSKEEIRKRVEEVAKILDIHHVLNHFPRELSGGQQQRVALARALVKDPSLLLLDEPFSNLDARMRDSARALVKEVQSRLGVTLLVVSHDPADIFAIADRVGVLVKGKLVQVGKPEDLYDNPVSIQVASLIGEINELEGKVTNEGVVIGSLRFPVSVSSDRAIIGIRPEDVKLSKDVIKDDSWILVGKGKVKVIGYQGGLFRITITPLDSEEEIFTYSDHPIHSGEEVLVYVRKDKIKVFEKN
The following text describes a protein:
Function:
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Sequence:
MHRRITGKLVIATHNPGKLAEMKELLAPYGIEAVSAGELGLSEPDETGNDFRSNAAIKAIAAAHASKLPSFADDSGIVVDALDGAPGIYSARWAGPTKDFTAAMTRIERLLQERGATAPDKRKAHFVSALCVAWPDDHLEEVEARVDGTLVWPPRGTAGFGYDPMFRPDGHTRTFGEMTSIEKHGLPPLGLALSHRARAFVKLAEICLEPR
The following text describes a protein:
Function:
Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.
Subcellular Localization:
Cytoplasm.
Sequence:
MVERVFRRPEVSCSEAGHLARSLFCITPITEVKELISTSDRNFFIEGFSTAFQASGKFVLKILNSSDSSNEELIYAENAAIDYLRERGYPCPMVLKAWNDKRLAKADLPVRGSIKGNGKDGTERCIIRLLELVPGETLASISTTSKMLYQVGEFIGSVSGSLQGFSHLAIDARYDRYDLKNFQDLEPYVCLLPSPKDRVVVREIFASFASEVVPLMEQFRYGTLHNDMRPSNILGIYNEQEDSLSITGLVDFGDIASSMVINEIVVAMAAFMEGNCNIEVSGYLLAGYQALFPVPAVEYRMLYLLVAARMCMLFVISSQNMHINKNNKYLKEVTRDNRALMLRFWAYSRDDVERVWMKCRNKFIKVLRDPLYDI
The following text describes a protein:
Function:
Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. Controls plastid size, shape, and perhaps division during normal plant development by altering ion flux in response to changes in membrane tension. Acts as a component of the chloroplast division machinery.
Subcellular Localization:
Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MMMRTVALPLSHDLNVHKIHEASGFHNSAAGKNRVYLTRTGLSSCATRQDVWSLQLLESLSGSIVPVSSRCNAFVCRSALSPGNGNEGPILKSTAVIFTRVYDALGGNPHLVKLIPAVGILAFATWGLRPLLRLARTTLFEKGNDANSQKSSTQYIVVSYLQPLLLWSGAILLCRTLDPIVLPSSAGQAIKQRLLIFARSISTVLAFSCCLSSLLQQVQKFFMETNNPADTRNMGFSFAGKAVYTAAWVAAASLFMELLGFSTQKWLTAGGLGTVLLTLAGREILTNFLSSIMIHATRPFVLNEWIQTKIGGYEVSGTVEQVGWWSPTIIRGDDREAVHIPNHQFSVNIVRNLTQKTHWRIKTHLAISHLDVSKINNIVADMRKVLSKNPQIEQQKIHRRVFLEDIDPENQALRILISCFVKTSRFEEYLCVKEAVLLDLLTVIRHHGARLATPIRTVQRMRNEAEVDTAGFSDIVFNQAAMNRRYMLIEPSYKINSDDNSKSPSPSPGQKSPSPGQKSEERDLQEEPSETKAETENNGSVPVSNAKKENQKAALGSNSNTGTKGSSTSTSDQPVAQKSEEKKKESVGDPHKAEKDEVSDDEATIEQTLKSKAKQGSEKNNGESKARDGGGSGTSSLLEENLVLGVALDGSKRTLPIDEEHKASGALMDSEELGIGSE
The following text describes a protein:
Function:
Catalyzes the ATP-dependent 2-thiolation of 5-methyluridine residue at position 54 in the T loop of tRNAs, leading to 5-methyl-2-thiouridine (m(5)s(2)U or s(2)T). This modification allows thermal stabilization of tRNAs in thermophilic microorganisms, and is required for cell growth at high temperatures (By similarity). Can use free sulfide as sulfur source in vitro.
Miscellaneous:
MISCELLANEOUS: In TtuA from T.thermophilus, the sulfur inserted into the nucleoside comes from the C-terminal thiocarboxylate of TtuB, but there is no TtuB ortholog in T.maritima; MISCELLANEOUS: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.
Sequence:
MKCTKCGKPASVKLRHYNIKLCKEHFNEFIEQRVEKAIKKFKMFGRNSKILIAVSGGKDSVSLWHMLKKLGYEVDALFIRAGKSGMVQKAQEIVEKNAELLNTKLHIVDATEYFGGLSTQEISIMLRRPVCSICGVVRRYLMNKFAYENGYDVVVTGHNLNDEASVLLGNILHWQEGYLERQWPLLPKTHEKLVPKAKPLVLNYEEDIKLYATLNEIPHLEMACPFSVGATSLVYKKILRELEEEQPGITLNFYLGFLKRKKEPKFEVEGLRECKECGYPTTAEVCSFCRLRKQVEKRKNKTPA
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MGNTATKFRKALINGDELLACQLYESNLQFKEALDPNATYGESYQHNTPLHYAARHAMIRLIRPFLLNKDGNPNKRNVHNETSLHLLCMGPLILTPEGALQPRILRPYEDEQRRAECLQIILSWTGAKLDHGQYERADVNASDNKKNTCLHYAAASGMTTCVELLVESEADLFAENENRETPCDFAEKQHHKELALRLESQMVFSLSPEAEDIEAEYAALDRREPYEGLRPQDLRRLKDMLIVETADMLQAPLFTAEALLRAHDWDREKLLEAWMKNAEECCQRSGVQMPNPPPSGYNAWDTLPSPRTPRTNRSSITSPDQISLLPADDESSLCGICMSSISVFEEPVDMSCGHEFCRSCWEGFLNLKIQEGEAHNIFCPAYDCYQLVPVEVIESVVSREMDKRYLQFDIKAFVENNPAIRWCPVAGCERAVRLNNQGAGTATGDSLSFPMLRAPAVDCGKGHLFCWECQGEAHEPCDCQTWKLWLQKVTDMKPEELAGVSEAYEDAANCLWLLTNSKPCANCKSPIQKNEGCNHMQCAKCKYDFCWICMEEWKKHSSSTGGYYRCTRYEVIQQVEEQSKEMTEEAEKKHKSFQELDRFMHYYTRFKNHEHSYQLEHHLLKTAKEKMEQLSRALRGREGGPPDTTFIEDAVLELLKTRRILKCSYPYGFFLEPKSTKKEIYELMQTDLEMVTEDLAQKVNRPYLRTPRHKIIRAACLVQQKRQEFLTSVARGVAPNDSPEVVRRSFAGGTWDWEYLGFASPEEYAEFQYRRRHRQRRRGDMSSIRSNTPDPDDLSDSTLDPQDVGGGRREGPLMGLGSLDEDDPNILLAIQLSLQDSGMAGSGSNHDVLTSEISLGAIGSSLPSRLEQTTPDVGVPPRASRSSSELLELEDKLVRVGNIGNQHSTATGAPFSVQHYEGHSWASSASVQLPVAPGNPSTTRLFPSSTDTAHSKPRSVHGPSSSSASATNANLLGNIMAWFHDINPQGITLVPPVSCDADLNVGPHQTSAAGCAHEDVNASAVALSENRNPEETPADVALNSQRLGCAEEERGVAERPTQLDLVGLGTMPTGALHTNAEPAESTCSKSCRVDTPLRDSVSDQLPSSSSSEWEEQVHLV
The following text describes a protein:
Function:
Negatively regulates mel-11 to relieve the inhibition of mlc-4, allowing contraction of the circumferentially oriented microfilaments in epidermal cells and thereby regulating myosin II contractility during spermathecal contraction, cleavage furrow contraction in early embryos, and embryonic elongation and morphogenesis. Required for P-cell migration. May also play a role in oocyte cellularization.
Subcellular Localization:
Cell membrane. Cleavage furrow. Cytoplasm, cytoskeleton. Endomembrane system; Peripheral membrane protein.
Sequence:
MPAGRETVTKQRSMDVERRRRANTLEREMRDPTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYDIPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERDEKPEEVFPVPKGFDGNHLPFIGFTYTGDYQLLSSDTVDAESKEANVANSGAASNNHGHGHNHRHRPSNSNELKRLEALLERERGRSEALEQQDAGLRQQIELITKREAELQRIASEYEKDLALRQHNYKVAMQKVEQEIELRKKTEALLVETQRNLENEQKTRARDLNINDKVVSLEKQLLEMEQSYKTETENTQKLKKHNAELDFTVKSQEEKVRDMVDMIDTLQKHKEELGQENAELQALVVQEKNLRSQLKEMHKEAENKMQTLINDIERTMCREQKAQEDNRALLEKISDLEKAHAGLDFELKAAQGRYQQEVKAHQETEKSRLVSREEANLQEVKALQSKLNEEKSARIKADQHSQEKERQLSMLSVDYRQIQLRLQKLEGECRQESEKVAALQSQLDQEHSKRNALLSELSLHSSEVAHLRSRENQLQKELSTQREAKRRFEEDLTQLKSTHHEALANNRELQAQLEAEQCFSRLYKTQANENREESAERLSKIEDLEEERVSLKHQVQVAVARADSEALARSIAEETVADLEKEKTIKELELKDFVMKHRNEINAKEAALATLKEAENELHKKLGQKAAEYEDLVQQHKKQQEELALMRSSKDEEITKLLDKCKNEVLLKQVAVNKLAEVMNRRDSDLPKQKNKARSTAELRKKEKEMRRLQQELSQERDKFNQLLLKHQDLQQLCAEEQQLKQKMVMEIDCKATEIENLQSKLNETASLSSADNDPEDSQDSVFEGWLSVPNKQNRRRGHGWKRQYVIVSSRKIIFYNSDIDKHNTTDAVLILDLSKVYHVRSVTQGDVIRADAKEIPRIFQLLYAGEGASHRPDEQSQLDVSVLHGNCNEERPGTIVHKGHEFVHITYHMPTACEVCPKPLWHMFKPPAAYECKRCRNKIHKEHVDKHDPLAPCKLNHDPRSARDMLLLAATPEDQSLWVARLLKRIQKSGYKAASYNNNSTDGSKISPSQSTRSSYKPYAVNVQRSATLPANSSLK
The following text describes a protein:
Function:
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
Subcellular Localization:
Nucleus.
Sequence:
MGALSRLGLPCLTAEAVAFLDGHGIYTVEDFLAYDLYRLGDGELQKQVIAGLLQHVAATTNCTWTDGATLFERLTTSTTLVSTGCPSIDDVIGGGLRPGTITELVGTSASGKTQLCLQAAAAAALELRASVAFIDTSNSFSAHRLAQIVTGLHGKDKFVEHKQELRNVARRVLCFKAFDIYTALRLLDDLLVHMDGAESKRGGDGNQGDFFQKLQLLILDSASAIISPVLGGAHTQGHALMVSLSGLLRQIALKHNIAVLVTNHTVSGEGGRPKPALGESWKSVPSVRLALAREDESDCCTATVTKHTIGACGESVPYVLSRDGLRAFEAEEPGATQQLEWRQE
The following text describes a protein:
Function:
Involved in the catatabolism of testosterone. Catalyzes the hydration of 2-hydroxyhexa-2,4-dienoic acid to 4-hydroxy-2-oxohexanoic acid.
Sequence:
MSDKQFIETQGQRLYEALRSARTLAPLTDNHPEMTVEDAYHISLHMLRLREASGERVIGKKIGVTSKPVQDMLNVHQPDFGFLTDSMEYEDGAAVSLKAAGLIQPRAEGEIAFMLKKDLQGPGVTREDVLAATEWVAPCFEIVDSRINDWKIKIQDTVADNASCGVFVIGKQHTDPASLDLAAAAMQMSKNGQPAGSGLGSAVQGHPAEAVAWLANTLGAFGIPFKAGEVILSGSLAPLVPAAAGDRFDMVIEGMGTCSIQFTE
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MKKLFKLFSILALSLIFLVSCSSIKSTMKSVASVFKSPTKYNNVTVTFVTTQGEITFFLYPEAAPLTVANFINLAKRGFYDNTKFTRSVDNFIVQGGDPTGTGMGGPGYTIPDEFVEWLDFYQPGMLAMANAGPNTGGSQFFFTFSPADWLNGVHTVFGEVRSEGDFQRIRKLEMGDVVKEVKISENGDFILSLFKDQVEQWNSVLDREYPNLRKVAIKDPNPQDVEAYKEELERLYAKKEKNNSDFEYPITKFIRKVFNKAGGYTPKAPVISN
The following text describes a protein:
Function:
Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration (By similarity).
Subcellular Localization:
Vacuole lumen. Cytoplasm. Note=Is released from the vacuole to the cytoplasm during stress conditions like oxidative stress or stationary phase stress.
Sequence:
MSSISGFLGAIPGAQQILQTMAGSLGLAPLSHPEIASSGSTFQQCGKLELSCQTSYHGQDTCCFNYPGGQMLQTQFWDADPAVGPENSWTIHGLWPDHCNGGFDQFCDSHRKYSNISLILIDAGRRDLLDEMSTYWKDYRGDDPNLWEHEWNKHGTCVSTLETHCYSEYYPQQEVVDYFDKTVELFHDLPTYMTLANAGIVPSYTQTYTRHEVEDALSKAHGATVTVRCRSQRLQEVWYFFNVEGPLQTGKFVPSEPDGQTSNCPAKGIIYQPKTPNKDPGHGHEPTKTRHPHGPTGAPFIGKGNLVVSTMGQQRGCIIGRGTWYSSGTCADFRAKRASGDTFTLSSRKGPCAFKDDIFTCGSYISSPAEFSAEDGKLSYHGNTTFFADKAPKGKVQSDIFVSEADHPIELSIAWRG
The following text describes a protein:
Function:
Involved in pre-mRNA splicing and cell cycle progression.
Subcellular Localization:
Nucleus.
Sequence:
MSQHELDIASSPGDVRPWIRYISSVKNDKTTARQKCILFERAVTALPRSYKLWKEYLDFRSGLCTGLNPIKHADEYDRVNALYEKSLVLLHKMPVIWLQYLQFLMLQPKVTKTRSVINEALRSLPVQQHPRVLKLALQFGTKVGGPTSVQIWKRYVLAYPDQKETMAQSLIKMGYHGEAAVVLIELLNASGDNYALWTELVDLIGESDKLTLEPPVEQIISSGIKRFPDQRGPLTVQLANFLVRNGDLESARDVFEDGITTANTVRDFTVVFDAYAEFEERIVTHLIENESPMADLRIAKLDHLLERRPFLISDVRLRREPYSVLEWQKRIALYEDPAETVAAYTEAVQSIPPAKADGKLSQLWISWAKFYAEDRETACEIYHKATLVPYKSVSELADVYLAWSQYESENDHWENAVKIIKQALESPNTHVSYHNSDLTAQDRIHKSVRLWSYYADLVESYGTFEETKQVYEKIMALDLLTPLFVVNYATLLEENDHFEEMFKVYEKGISLFEESAFEIWNLYLVKASPRLGLERLRDLFEDAISKFPTQKALYILYGKLEEDRGLVRNAMRVYSAMCDHVKTSETFKYYIGRTVENFGLAATRPVYDKALESLPNKDASELALDYAQMEEKLGEIDRARAIYGYGSQFSDPQIIKYYDAWHKFEVAHGTEDTFKDMLRIKRSIQAQFNTDIHYATTAAEVKKGTVQEFVKGETVQKGNIEPPVAQANEDEIELDI
The following text describes a protein:
Function:
Transcription activator. Binds to 5'-CAACTGTC-3' and/or 5'-TAACAAA-3' motif in target gene promoter to promote their expression (By similarity). Together with MYB101 and MYB120, functions as a male factor that controls pollen tube-synergid interaction in fertilization. Required for pollen tube growth arrest and sperm cell release in the female gametophyte, probably via the regulation of pollen tube-specific gene expression.
Subcellular Localization:
Nucleus. Note=Detected in the vegetative nucleus of pollen tubes.
Sequence:
MIVYGGGASEDGEGGGVVLKKGPWTVAEDETLAAYVREYGEGNWNSVQKKTWLARCGKSCRLRWANHLRPNLRKGSFTPEEERLIIQLHSQLGNKWARMAAQLPGRTDNEIKNYWNTRLKRFQRQGLPLYPPEYSQNNHQQQMYPQQPSSPLPSQTPASSFTFPLLQPPSLCPKRCYNTAFSPKASYISSPTNFLVSSPTFLHTHSSLSSYQSTNPVYSMKHELSSNQIPYSASLGVYQVSKFSDNGDCNQNLNTGLHTNTCQLLEDLMEEAEALADSFRAPKRRQIMAALEDNNNNNNFFSGGFGHRVSSNSLCSLQGLTPKEDESLQMNTMQDEDITKLLDWGSESEEISNGQSSVITTENNLVLDDHQFAFLFPVDDDTNNLPGIC
The following text describes a protein:
Function:
Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
Miscellaneous:
MISCELLANEOUS: Oxidizes N(1)-acetylated polyamines on the exo-side of their N(4)-amino groups. Plant PAO oxidizes spermine on the endo-side of the N(4)-nitrogen (By similarity); MISCELLANEOUS: N-ethylated polyamines are also good substrates for this enzyme: they have been used for cancer clinical trials. They down-regulate polyamine biosynthetic enzymes, but dramatically up-regulate SSAT synthesis, which results in mammalian cells becoming apoptotic.
Subcellular Localization:
Peroxisome. Cytoplasm.
Sequence:
MAFPGPRVLVVGSGIAGLGAAQKLCSHRAAPHLRVLEATASAGGRIRSERCFGGVVELGAHWIHGPSQDNPVFQLAAEFGLLGEKELSEENQLVDTGGHVALPSMIWSSSGTSVSLELMTEMARLFYGLIERTREFLNESETPMASVGEFLKKEISQQVASWTEDDEDTRKRKLAILNTFFNIECCVSGTHSMDLVALAPFGEYTVLPGLDCILAGGYQGLTDRILASLPKDTVAFDKPVKTIHWNGSFQEAAFPGETFPVLVECEDGARLPAHHVIVTVPLGFLKEHQDTFFEPPLPAKKAEAIKKLGFGTNNKIFLEFEEPFWEPDCQFIQVVWEDTSPLQDTALSLQDTWFKKLIGFLVQPSFESSHVLCGFIAGLESEFMETLSDEEVLLSLTQVLRRVTGNPQLPAAKSVRRSQWHSAPYTRGSYSYVAVGSTGDDLDLMAQPLPEDGTGTQLQVLFAGEATHRTFYSTTHGALLSGWREADRLVSLWDSQVEQSRPRL
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MTTAHRPQFDPARGHSEMAPTRITSSRALPAHLKLKYRQESQGTEEEVRKQDLREALLRAEAAHFATQEHGASSEEVSQNSKLIEGFTSPSTDDKPNNDVEVDYQELLRQTLEADEDASDSDDSVDSSNKNSEVSIKRRKTESNSQESVDSSNSESSDEESDSEDETQQLLRELENIKQERKREQMLQEEKNRALEQEKREREIAFGNELLNKASSGSFQVKRRWDEDVVFRNTHKGVDDTPRPGFVNDMLRSEFHKKFLARFVD
The following text describes a protein:
Function:
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MTGARRWAPLLLCLLQSAPGRPLLAPPQNVTLLSRDFSVYLTWLPGPGNPQNVTYFVAYQSFAPPRRWRRVKKCAGTKELVCSLMCLEKQDLCNKFKGRVQAVSPSARSPWVESKFMDYFFEVEPAPPVLVFNQTEEILIVNATYQLPHCLPQPDMNYEVNFWKEGTKNKTRFPDTRHGQPVQIPLQPDTSGHHCLSARTIYFFGNPKYSEFSEPTCFFLEAPGSNWALLLLLPFLLPLLLAVAIGPVMWKTFRENPWFQQTKMPQALSFSGHRLCGATFQPGGPECLHDLIVCPQKEVTRRVRLTSRVRAPAPVQARPEKDSAEEKDGEESTDEEDLDPGVSFQPYVEPPPFLGQEPQSPGPTKAGEPWTPLVQGEGSSACSSSGRSWVSTAGSSSPWDEAGSSGYLAKKGPGQGMGREEHQKPLPPPKDSSSLGEPSKDNLSSWTSWGLSSPGLNLVPGEPPVSLRTLTFCWDSSPEDDEGEEEEEEEGWRESESEDSGAGSWGAKSLQRTEVRPLGHYLAR
The following text describes a protein:
Function:
Catalytic component of the RPD3 histone deacetylase complexes RPD3C(L) and RPD3C(S) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Miscellaneous:
MISCELLANEOUS: Present with 3040 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The NEE-box motif is required for the association to RPD3.
Sequence:
MSTLDIAEDNKIKNEEFKIWKKSIPSLYQHISSLKPIFGSGVDESPSTLRSIVFTNDSSCNKSKGVLSVPLLYSQGSEIFEVDCIVPLGLHYKKPESISEPLVQPDYTMESQKVEQTVLIPKWEFKGETIAKMIYVDNSEINVKVIALSTNGSLAWFREGVKSPVYTMMEPSTSLSSASSGNQNKPCVDFAISNDSKTLTVTKEKHLDNENATIKLIDNSGKIGEVLRTIPVPGIKNIQEIKFLNNQIFATCSDDGIIRFWGNEIGKKPLWILNDSLDGKTTCFAASPFVDTLFMTGTSGGALKVWDIRAVIALGDADAELNINQGHNKVNELFKVHHFYSEQVSKIEFSSISPMEVVTIGGLGNVYHWNFEPVFAIYNEIHEDFQGIISDELEAESMAFYHTEGCRREIGENNKVNTVAYHKYIEDLVATVDSDGLLTVYKPFTGKVLDGSREVGAAKS
The following text describes a protein:
Function:
Involved in the regulation of mitochondrial distribution and morphology. Required for mitochondrial fusion and mitochondrial network formation.
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
IKNMVREIITLQNGRYSNFVGTHFWNIQESSFEYSGDSSQPEIEHDVLFREGKNLLREVTYTPRLVVIDLKSNLGCLPLEGTLYPTPAHQNGGSEIPTWGDGVEVVEASRSKKNEFIKDLELEEQKYYQATNGVEKSNEKNEKQIKAKTYKLEDKVKTWSDFKRLHFHPRSILTLNEEDDSFTSWSGGFEHGKYISYQVEDLVRVYAEECDNMQGFQVMSDVNNGFGGVLTSLMEYLSDEFRGKGLVVYPMLPVRNEKTAPKVRSSSLATLLSLSESLKLSTLVAPMSLNSDIFRQNPRKREFPRLIYDATCDYHTSSILATALESITRVHRCHTDPQSLSNISQQLSIGSQKLVSTGAAIPIPFSSNYSCLPDMLCDHLDKSLWTSLTPCVDDAKSKGDVVDRCFSQSLSINGFPPSAATASTTHPEYNISQIHQCTNLTSVLKLYLEGKYVDSSSVVSVQRTPIKVDTPFPQIFHSSLTSTGFPSNLDSPVMTNVESLPVLTNVMNSNSISSLLQ
The following text describes a protein:
Function:
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). Has an in vitro catalytic efficiency for PNP approximately 300-fold lower than that of PPOX1.
Sequence:
MGTHVAPWKQLLFGAIEANSHLSHSSYVQLATIGLNGRPSNRTVVFRGFEENSDRIQINTDLRSRKIEELKHCPFSEMCWYFSDTWEQFRINGRIEVIDASNPDQTKLQQREKAWFANSLRSRLIYVCPTPGSPCNSEQSSQQVKLDPSSGPVPEYCLLLLEPEKVDYLNLKTNQRLFFSSMATGTGEKCWTSEKVNP