lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Sequence:
MEAMSPQQETLGGQPGRSSSLTGVSRLAGGPGTKKKMKTLAERRRSAPSLILDKALQKRPSTKESPSASVDTCTFLSSFVCSSRTLLIDGRVELKRGLQRQERHLFLFNDLFVVAKIKYNNNFKIKNKIKLCDMWTASCVDEVGEGNTNATKSFVLGWPTVNFVATFSSPEQKDKWLSLLQRYINLEKEKDYPKSIPLKIFAKDIGNCAYSKTITVTNSDTANEVINMSLPMLGITGSERDYQLWVNSGKEEAPYPLIGHEYPYGIKMSHLRDTMVLTQGSKGSSAPSSLQESLLTEQLPREAQCQFILKPSRLAAAQQLSDSGQKTFKRRRSIINWAFWRGSSTHLDNLPVSPTSPMPGQLFGVSLPNICKNDNLPKHVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEVHLDCESVFVIASVFKDFLRNIPGSIFSSDLYDQWVCVMDQGNDEERINTIQRLLDQLPRANVVLLRYLFGLLHNIEQRSSSNQMTAFNLAVCIAPSILWPPTSSSPELENEFTKKVSLLIQFLIENCCRIFGEEITSLLGQVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDAPCSDLVKKLGQGSRSMDSVLTLSDYDLDQPEVEGLLTLSDFDLDRSKDEDIQMERPLESKPVNIAVVYTKVPLRDHARAPSGMSTPSYLSTAAADVPKSLRRHRRCSEPSIDYLDSKLSYLREFYQKKLRKSSCDAILSQKDEDYLKQNQPLQEEGKTYFKQSLVAGTDNKKNATNKNVKKKSLSGGEGNHMKLFSKSKPVAISVASYSHMSSQDHPRNQPFGADTSGYSPPHAADAIKGSRRHRRCSEPNMDDQHCKLTYLRGIYSKKQHKTSYEAGLFHGEEDYLKRHKSLQMEGQKLINQSLVMGIEVGKSSGTNQNPEKGLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDSAFSQISEHSVFTPTETSSPIDCTFQAQRKQEELSSDFSNSSLISATPGPSSGQASSHLAYMKKDTVEWHSQIHSVTLHPSTWLRNGVASLKNWSLKKKTRVCRPEEKKVISLKGPTEQPPHAPGISEASPLPERQKDMLQRAPEELGTVQTAQWYSSYPSQDSERHCSSPFSLVEDGLKLCVKSHKDEENNEQCSPGSLSCRRSSPSSLSVDDVSSPNLGPTMVSDPGDQHLAKDI
The following text describes a protein:
Function:
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
Subcellular Localization:
Cell junction, adherens junction. Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell projection, podosome. Cytoplasm, cytoskeleton.
Sequence:
MPVFHTRTIESILEPVAQQVSQLVILHEEAEDGNAMPDLARPVQAVCAAVQNLVKVAKETAETSQDVILKQEMPIAYTRVEEASHLLVDASDMLRADPYSRPAREKLIDGARGILSGTSQLLLTFDEAEVRKIIRVCKSVLEYLAIAEVVETMEDLVTFVKNLTPGMTGMSKMVDARSKELTHQQHRESLAHSLQVVKDLTPVLISGIKIFVTTRRPQDGKGIPEAIENRNYVVNKMSAEISEIIRVLQLTTYDEDSYDADDMTVMKKALASFMARLNQAREWLQNPNSEAGSLGERSLRQIIEDARRIGERCVGPERDEILRLCSELTAMVDQLSDFKAKGMGNSPEAINLSRQIIDRLLDMDKRVQQAVSNFQQSGIRKPAPTIAGKMEQAMRWLSAPTMDDKGLGQQAVHELVREGRKLAQTCQEPDKSDLLRKCDSVERLARQLADLVNQGKGDSPEAQELARTVQEKLNDLRKKMDETLVKQIADVFLDTTSALKQLNNAAHAPADAPNREPEFGNKAGNFDQHSALLTQTAGRVADAGSCQNKKTVEGIKSTAGVIRDLTPQIIHAGKILLDNPDNQSSGFNLHRAASEHFELLKREWMNNMDKLTSLVDDAVDTVAFIKACEEAIARDSEMVKVAIKNVQVQSVVNGASNIARRANRVLMVAKREADNSEDPKFVDRVNDASDTLARSISPMVVDAKSVASNPKDANSQGRYFDSNTKESAQRLPGEMDTLRDAVAGVREAVTVVDEAALAAAQEAAFPPPPDLSQLKLGDAAPPRPPLPEHETPPPRPPPPEEEEEEIAFPTPKPNQPIMTDSEDEEMAFPVDPNANEKIMVAAHQLHLEAQKWSSKGNEIVAAAKKMALLMAEMSRLVRGEGGNKRDLIRVAKEIALVADEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMIGQSTPDSNTDVDSEEVDQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGITLRWVRKKPWEEEQAAQESKIFDSIEKQMKTGKPYKYKGMPGVI
The following text describes a protein:
Function:
Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells (By similarity).
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context. Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm (By similarity).
Sequence:
MANGTNASAPYYSYEYYLDYLDLIPVDEKKLKAHKHSIVIAFWVSLAAFVVLLFLILLYMSWSGSPQMRNSPKHHQTCPWSHGLNLHLCIQKCLPCHREPLATSQAQASSVEPGSRTGPDQPLRQESSSTLPLGVFQTHPTLLWELTLNGGPLVRSKPSEPPPGDRTSQLQS
The following text describes a protein:
Function:
Guanine nucleotide exchange factor for arf-6 (By similarity). Involved in response to injury in mechanosensory neurons. Inhibits axon regrowth via microtubule dynamics, possibly by inducing axonal microtubule catastrophes. Limits microtubule growth near the cellular cortex of early embryonic cells.
Subcellular Localization:
Cytoplasm, cell cortex. Cell membrane. Note=Present throughout the embryonic cortex during the first embryonic mitosis, but at reduced levels in the posterior cortex. Localizes to the plasma membrane of the soma and processes of neurons. Localizes to the cellular cortex in the steady (uninjured) state. Following injury, transiently relocalizes to the sites marked by the microtubule minus end binding protein ptrn-1 together with tac-1.
Domain:
A short conserved N-terminal region is necessary for the function of this protein. Transient relocalization to microtubule minus ends after neuronal injury also requires this region.
Sequence:
MAKVASSGAEEALATIDGAPRRNVKKSEAFVMSGDVLISLNRNVSSTYAKLLGDQLPPGTTVASSIHPHQLSRATASAGVSFPSMNRNGAAAQKLSRLPVPVSTSQIERRGSLARKTSEESSPTAIRMLKTAPIERMESTDVEESEEETVMMTTDEKENQKKPNENDDEVMVVDEEQFIVVSNDMKSPNEEIVAKSLRSAMFTMPTDNHHHSYNSSPQISTLSPHLRSNGDGPSRSPVYDDVDDDLNGSLDAKDMSNNSHQQSFRSPENYSEKDTPSKHSVVTIDGSGVSNHYDQDGMFSHVYYSTQDTTPKHGSPSLRKQIFESRTTPNTAASNSSASASPSLHATSESRGATGGVSLRSAESSNLNQTAVPSTSTNSVGGEREAAQIARNLYELKNCTSTQVADRLNEQNEFSFLILVKYLELFQFSTTRIDAALREFLSRVELRGESSARERLLRVFSARYLECNPAIFDSLDEVHTLTCALLLLNSDLHGPNMGKKMTARDFITNIAHTGCTFKREMLKTLFQSIKDNAISLQNSAKNSTANGSVASTSRRQPQQIYEVDPDSVVEYYSGFLMRKYVRETDGGKTPFGRRSWRMVYARLRGLVLYFDTDEHPKATSRYASLENAVSLHHALAEPAPDYKKKSFVFRVRIAHGGEILFQTSNQKELQEWCEKINFVAAAFSSPTLPLPVTSKPETAPMPRLPRIPCLAPITKQLSTHEARVAELNEMIEIVSQSVSPNQPQQLITDRWVLLSFEKRRYSTYINVLRRSLEARKASSATTMNIMMTPTRRQQQNQKPVVSEDRLSYTDAVNGAAAH
The following text describes a protein:
Function:
Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly (By similarity).
Subcellular Localization:
Periplasm.
Sequence:
MSSTPREYRRRMKCSLKRLIYAVNFLFFLFTFSLDLESLIKNELRKEFGEEVRLKNYKVLTGIPDNFSKVELKVYKNSPRGFLHLKNTKVGTIALELEWKCRVLVAKRDIYPGERLNFSNVEEREIYLERCPQNFKENFVNFVALKEIKKGTIVRRSYLKKEFLVKRGEIVNAVYENGNVVIRFRTKALENGYYGEVIRVLSPFSRKVIRGKIIGEGTVKILR
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Involved in nuclear poly(A)+ RNA export and NPC biogenesis. It is also required for normal nuclear morphology. Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis.
Miscellaneous:
MISCELLANEOUS: Present with 952 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Symmetric distribution.
Sequence:
MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITAQQ
The following text describes a protein:
Function:
High affinity cysteine-specific transporter. Major contributor to cysteine transport when cysteine, at low concentrations, is provided as the sole sulfur source.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSKVDVKIGADSISSSDEILVPSRLADVTLAFMEENDAAVPEITPEQEKKLKRKLFLTIFTFVSAINLLLYMDKATLSYDSILGFFEDTGLTQNTYNTVNTLFYVGFAIGQFPGQYLAQKLPLGKFLGGLLATWTILIFLSCTAYNFSGVVALRFFLGLTESVVIPILITTMGMFFDASERAAAQPFFFAACMGSPIPTGFIAYGVLHITNPSISLWKIFTIIIGGLTFIMTVVVILWFPNNPADVKFFSIQERVWIIRRVQASTGSSIEQKVFKKSQFREAMKDYITWLFGLFFLLQQLANNLPYQQNLLFEGMGGVDALGSTLVSVAGAGFAVVCAFIATLMLAKWKNISALTAIFWTLPALVGSIAAAALPWDNKIGILANICMAGQIFGIPFIIALSWASSSASGYTKKLTRSSVSLFAMGIANIISPQIWREKDSPRFLPAWIVQIVLSFSLAPAILLLIHFILKRRNNQRLKNYDENLQNYLDRIQLIESENPSSIEEGKVVTHENNLAVFDLTDLENETFIYPL
The following text describes a protein:
Function:
Directs the termination of translation in response to the peptide chain termination codon UGA. Required for the proper translation, stability and normal processing of UGA-containing polycistronic transcripts in chloroplasts.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MSMELTVLGPLAGRSFAIAGKPKLLLLRPTNLPLLRLSLPLSLPNFSSSSRFNSPIVFAAQESNLSVSNENETSEWLMQDFYTLRKDVEIASARVEEIRASANLQQLEQEITNLESKATDTSFWDDRTKAQETLSSLNDLKDRMRLLSEFKTMVEDAETIVKLTEEMDSTDVSLLEEAMGIIKELNKSLDKFELTQLLSGPYDKEGAVVYITAGAGGTDAQDWADMLLRMYMRWGEKQRYKTKVVEMSNGEEAGIKSATLEIEGRYAYGYISGEKGTHRIVRQSPFNSKGLRQTSFSGVEVMPLLPEEAVGIEIPEEDLDISFTRAGGKGGQNVNKVETAVRITHIPTGVAVRCTEERSQLANKTRALIRLKAKLMVIAEEQRATEIKEIRGDAVKAEWGQQIRNYVFHPYKLVKDVRTGHETSDITSVMDGDLDPFIKAYLKHKYTLAMASAVTN
The following text describes a protein:
Function:
Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MEERERGARSARAASPARPPSPRLDVSSDSFDPLLALYAPRLPPIPYPNAPCFNNVAEYESFLRTGVRGGGRGRARGAAAGSGVPSAPGPSGRTRRRPDAPAPDPERIQRLRRLMVAKEEGDGAAGAGRRGPGRSRKAPRNVLTRMPLHEGSPLGELHRCIREGVKVNVHIRTFKGLRGVCTGFLVAFDKFWNMALTDVDETYRKPVLGKAYERDSSLTLTRLFDRLKLQDSSKKEADSKSAVEDSTLSRYSQTSTWKLASVWGRGDTDRGSHKRSRSVPSSLQASAREESRSELSGRTTRTEGSSVGGTFSRATTLSRGQSRKKKRKPKVDYQQVFTRHINQIFIRGENVLLVHLAQ
The following text describes a protein:
Function:
Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory (By similarity). Promotes synaptic vesicle fusion to positively regulate the release of dopamine at dopaminergic neuron synapses. Displays high selectivity for sodium ions but can also permit the permeation of other cations (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane. Cell projection, dendrite.
Domain:
The second transmembrane domain (TM2) is a discontinuous alpha-helix disrupted by the GAS motif, which forms the selectivity filter by adopting an extended, belt-like conformation aligned approximately parallel to the membrane plane. This peptide belt encircles the waist of the channel and divides TM2 into two discontinuous helical segments. The distal helical segment of TM2 interacts with the cytoplasmic portion of the first transmembrane domain (TM1) from a neighboring subunit, contributing to the structural and functional integrity of the channel.
Sequence:
MGKNSLKRALELDVVDFAEHTSAHGIPRAYVSTGWRRYMWLLCFLFCLSCFGHQAYLIVERFNRNDIIVGVEIKFEEIKFPAVTICNMNPYKNSAARELGAIRNAIEAFELAIDKSDGNAHSKRKKRSANSKMVPIDLLCKEEHGMFTAHDYGHVECTCVTFEDMSKVGDTDDDEIFWNCHQRKDWTHKICHLAEGSNQLKTCKCFEDTCVSDEVTKQLVWPLQLSKNGTKLCISPESSGPRYCASAQKFQVSTCSNCDWLGKCEESDDMDLEEEIDSKTCICHHGNCFQIKGNVKKRKRRTPERKVHERLLSRYEGLLAVYSHCNCTKQHGCVSTSVPDMDLENSNKTCLCFYNKKNEQIWPCYKEPEWEERKCSRCNTMGDCVYSDKPKKQTISCLCATPIKMCVRIDPPQTNDTSLDDRVVKFWDIQPSTTMSPIVKKKEERDKAYGYTGVKDRIALRAKAMENMIFAVDALTEEEKWKISYNKSDFIMKCSFNGRECNVKHDFVEYLDPTYGACFTYGQKLGNNTNERSGPAYGLRLEVFVNVTEYLPTTEAAGVRLTVHATDEQPFPDTLGFSAPTGFVSSFGIKLKSMVRLPAPYGDCVREGKTEDFIYTQKAYNTEGCQRSCIQKHLSKTCGCGDPRFPPYRESKNCPVDDPYKRECIKNEMHVATRDSKKLGCSCKQPCNQDVYSVSYSASRWPAIAGDLSGCPLGMAAHHCLNYKREQGSMIEVYFEQLNYESLLESEAYGWSNLLSDFGGQLGLWMGVSVITIGEVACFFFEVFISLISSNRTKRRPARKSFSSSLRCSTDYNLNKDGFNLDN
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 2840 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MLRFTGARAIRKYSTRYALEHLKEGAPLKGLFSIEGLQKAWFDRVKYLDAKLNDCTNEAQQKPLETLIHENSKSASKKHIVNYASSLYNLKFSMSSLQGCIRTPPEECPRLGPEALLQTPDFNRTISNEPLTTGNERLQAALISSFGSLMEFRTLLINSNLAISGDGFTWLVARRQLDKRAMRNDMPNRDIEYDKLFILNTYNAGTPFNFSTSGVMNELNNQYTNMEKQRAKEAGNLEDSEMTAKQAKTKFIYETQQKGFSGKEVSYIPLLAIDASPKTWLTDYGVFGKREYLERVWDSIEWKIVESRLPQRTKIQAFNTL
The following text describes a protein:
Function:
May act as a substrate receptor of a CUL4-RING E3 ubiquitin-protein ligase (CRL4) complex involved in the negative regulation of cellular responses to ultraviolet-B (UV-B) illumination, likely in coordination with RUP1. Interacts with COP1 and probably prevents the formation of active UVR8-COP1 complex, thus avoiding UVR8-COP1-mediated positive regulation of UV-B responses.
Subcellular Localization:
Nucleus.
Sequence:
MATLTEIATLEEKYIELCKMHGILPNTAILSAFFEAEVKKSRNQRCIMNLYVDRVKYDDYLPLLELCNEINTSEVQGIDLFVRSACSLEDHYALPLIRSVNQKLRVVHLHDSFGKNFWQDVFFQGLSCKVLNVRSMHIHKLNIVGEFTQLHTLILDKNRIVGFGEDCFSCMPKLTYLSMCDTLVSDLWTSAAALLKLPSLKELRFQIWISCSDSSPLNSESSPSSSTKDDINTFIESDPPVEADMWDVAEQMDPSLPVEETLHSMDFSYKIPEQDDLDSHVSVSAGLNGEVLMREKVRRGKMPYQPKDVSPVDTFTRQFGNVGLKYISSKASPICSEKHYRMYMINSLPKLQVLDNLAIRKSDRDKAIETYSANFEDLPYKRKKESVVRVLENREKRSSKGKSQNSYKRSLCAAKMGSPASPLLHSLPFLSSRIQQEDDNSRLCPRQFEYHPLDPSLMVFGTLDGEVVVLNHESGKIFRYIPSNGSQSTILGLCWLKIYPSMVIAGSANGSLKLYDIQKASSTVTTSSHSTSGSVTFDEFDQLTSVHANSTDQLFLASGYSKDVALYDIGRGTRLQVFANMHQEHINVVKFSNHSPFLFATSSFDKDVKLWDLRQEPSRPCYTASSTKGNVMVCFSPDDRYLLASAVDNEVRQLLTVDGRLHLNFEIVPRVSSMNYTRSYYMNGNDYIISGSCDENVIRVCCAQTGRRLRDVTLEGNGSDFSMMYVQSLRGDPFRDFNMSVLAAYARSSSLSEIVKVNLLASRDSTAEESHGLRSYPSSSMGG
The following text describes a protein:
Function:
Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.
Sequence:
MVSDNPLQQVRESANWVNEHSDNVKINFNKINEFLDNLKKDDYESKSSTVLFPLNYSNSQQEINFWFLLDLINFGSGYRKELHEACNRGAYETICYGLMGMFLSQGGKLTANFLSNMSLNDVSQLFNIPTQEEFEIQAGIYSYRDTPLKQLAQSIHTVLKESSEIVLKLGFQDFGDWIWSITDPSKRSSSSSSTTPLASDLVKILVETIPAFNDQANYKGHRIFIFKKVQLLAADLYRRFKDTIPDRFNFTDINDVTVFTDNVLPAVLRNFGILEVSKELEERLNAGAELLPGNDEVELRVQAIQACIEIVSIAKKRTDNFIKNDVEFDYYLWTKGKDGVIRKVERHYTKKTIFY
The following text describes a protein:
Function:
Cargo protein of a type 1 encapsulin nanocompartment. May help nucleate Fe atoms in the interior of the encapsulin nanocompartment (Probable). Present in about 92 copies/encapsulin nanocompartment.
Subcellular Localization:
Encapsulin nanocompartment. Note=Probably lies against the interior face of the nanocompartment.
Sequence:
MPQTNPFHSLVPRKMTDTELARSIRLNIEAELDAINLYAAHIDATDNEDAKAILQHVMDEEREHAALFWELIARLDPEQAAHAKEAVEKYRLITSGASHEAVEAVGKEGAAPSPADVTPEKRLTVGSLRR
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MVGSRLPTKPSHNILSLLGQSGLMTSSDPRSLQSLKITSKGFGFLLEDVNTQLWDILLQYLKMTEANGLDVVDVLACLFMLGSLELGQEYSFSNWTPTQTQVLQDLVDYGLVLVSAPDRFYPTRLATTLTSTAPPLVSAERAQEEHGFLVLETNYRIYAYTSNPLQIAVLNLFLSLRYRFPNLVVGAVTRESIKSALSNGITADQVIMYLHTHAHPQMRKLEPLLPPTVVDQIRLWELEKNRIRAQEGYLYEDFKSAAEYDSVIQYSRKLGIVLWEHAGLRKLFVGYDGHLTLREFFRRGGASNGNIEQSRVNLGDRSSDLGSAWAAPDRLSCKLLHNTRRWSTTLGGSDAWRPPNFSSMDQHQSNHPMRSLLDKTYATSTSTQNIAILSPFVQLSFVFHLAIAQLQRHIQETPDCVVTVIGSSSQAAFQNTLADEHDAVLFTDSSSDCLTKTLLERIEFRSVSSRRPPQLLTLLCELGHSPVERPTLNDDEEDRGMRSPRIGLIITDLTSYLISLPTPTLSDLTRLLGFLSCTQTRLPSIHHHHHHPLQNPPPIYLVDRVDHNQKWPLSTPTADPEDLRNILEIFRHFFAQIWTIDGLHETDSNTGDDSPTTTPTAVGTSSSPKPGRYRLYSLRSAADSSADDDDQITYQVLEQEALDPEYSAHPERLLRKTVVVPGC
The following text describes a protein:
Function:
Required for pre-rRNA processing and 40S ribosomal subunit assembly. Seems to act in the processing of 35S rRNA at the A(0), A(1), and A(2) cleavage sites.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTLDDDDYIKQMELQRKAFESQFGSLESMGFEDKTKNIRTEVDTRDSSGDEIDNSDHGSDFKDGTIESSNSSDEDSGNETAEENNQDSKPKTQPKVIRFNGPSDVYVPPSKKTQKLLRSGKTLTQINKKLESTEAKEEKEDETLEAENLQNDLELQQFLRESHLLSAFNNGGSGSTNSGVSLTLQSMGGGNDDGIVYQDDQVIGKARSRTLEMRLNRLSRVNGHQDKINKLEKVPMHIRRGMIDKHVKRIKKYEQEAAEGGIVLSKVKKGQFRKIESTYKKDIERRIGGSIKARDKEKATKRERGLKISSVGRSTRNGLIVSKRDIARISGGERSGKFNGKKKSRR
The following text describes a protein:
Function:
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
Subcellular Localization:
Nucleus.
Sequence:
MGLEEELLRIAKKLEKMVARKKTEGALDLLKKLNSCQMSIQLLQTTRIGVAVNGVRKHCSDKEVVSLAKVLIKNWKRLLDSPRTTKGEREAREKAKKKEKGLGSSGWKPEAGLSPPRKKEGGEPKTRRDSVDSRSSTTSSPKRPSLERSNSSRSKVETPKTPSSPSTPTFAPAVCLLASCYLTGDSVRDKCVEMLSAALKAEDDFKDYGVNCDKLASEIETHIYQELKSTDMKYRNRVRSRISNLKDPRNPGLRRNVLSGTISPELIAKMTAEVQTRSADEPMTTFVLCNECGNRWKFC
The following text describes a protein:
Function:
Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MEPALGPGVQKDLGYLQQWLKAFVGTFEKSISLSSLEPRRPEEAGAEVPLLPLDALHVLTEQLAERDLEQALLLLKLFVVLCRNPENVEAGWGRVLVPQVLALLTWLVAELKGPPPPQEARGSQLENAALHALLLFEGLFDPYQTWRRQQSGEVISSKEKSKYKFPPAALPCEFSTFFRESLQDADRLPPVLLLRLIHLFGAVLAGGKENGQKAVSAGSVQGLLGVVQAWGHRPAQDPRLVPLALKALVGAVHILHASRTPPRGPELRALLEGYFRVLNTDWPAGPSPDPEEALVTLRVSMLDAIPMMLACEDRPVLQATFLSNNCFEHLIRLIQNSKVLDQDTDAIAVHVVRVLTCIMSGSPSAKEVFKERIGYPHLHEVLQSHGPPTHRLLQELLNMAVEGDHSTCPPPPIRNEQPVLVLMRWLPALPTAELRLFLAQRLWWLCDSCPASRATCVQAGLVGCLLETLSTGVALGTRCQEQLLALLQALGHVSLRPLELRQLLRPPPGLDSGSSVAEAENARHAGAIIRALSGMARDRGPARALHYFDLTPSMAGIMVPPVQRWPGPGFTFHAWLCLHPMAAAPVPAPTPTPTRPLQRKQLYSFFTSSGSGFEAFFTAAGTLVVAVCTRKEYLTMSLPEVSFLDSTWHCVAIVHVPGRRPFSQNLVYVYKDGHLVKTATLRCPSLNEPFSSCCIGSAGHRTTTTTTGLPAPSVPAALAHTHPSLTRSQSVPATTGLGWGSGLVAPLQEGSISSTLAGTQDTRWGSPTSLEGELGAVAIFHEALQVEALRVLCNLGPNETAPFKPEGELHELATKLLLHYSPQACKNNICLDLSPGHGLDGRLTGHRVETWDVKDVVNCVGGMGALLPLLEQVAAQPQEAEAGPAETHDLVGPELTSGHNFQGLLLPLGKSSAVEERMERNAVAAFLLMLRNFLQGHAVNQESLVQCQGPAIIGALLRKVPSWAMDMNVLMSAQLLMELVAAEGSGPLLYLLYQHLLFNFHLWTSSDFAVRLGHIQYVSSIVREHRQKLRKKYGVQFILDALRTHYSLQRERPLAADDLRTVQTSLLGLVREFLVRSSSSDDLQVVLNFLAAGVDDGQVVGVLDLLLALLQSLPAQESLAIFLLEPGNLEVLLALLVRPRSTPSLPDRVCKILRRLQQNERLPERSRQRLRLRECGLQGLIACLPEGAVSPQLCQGLYKLFLGADCLNLSDLLAVVQLSLQADLSVRLDVCRQVSGRTSLYIVRLLARQAGWQDVLTRLFVVEAVTAGSPLPFSPEPPTSPEPALHKPPTESPESSDVFLPSEAPSPDPDSFYHALSPFCTPLELGLERSSVSSGNTAGGGSGSGTLTPASQPGTPSPLDGPRPFPPSRGRHSSSLSNVLEDGSLPEPTISGDDTSNTSNPQQTCEEELCNLLTNVLFSVTWRGVDGSDEAAWRERGQVFSVLTQLGASATLVRPPDYIKRSLLEMMLESALTDIREAPLGVLASLTQQALWLLRLLQDFLCAEGHGNQELWSEKLFEGVCSLLDRLGAWPHLANGTADFREMAQIGLRLVLGYILLEDPQLHAQAYVKLHALLQTTVPMRREEACYVLSKLEAALARALSTLPSENPAGVEEPPAAATAAERCSWLVPLVRTLLDRAYGPLGLQWGLPSLPPTNGSPTFFEDFQAFCATPEWRHFIDKQVQPTMSQFEMDTYAKSHDLMSGFWNACYDMLMSSGQRRQRERAHSRRAFQELVLESAQRRARLEGLRYLAALKQQAAQHSTALLHWGALWRQLSSPCGPWALRDPPTPHWKLSSAETYSRMRLKLVPNHHFNPHLEASALRDNLGEAPLTPTEEASLPLAVTKEAKVSTLPEELQEDQLGEDELAALETALEAAELDEQHEKLVLSAECQLVTVVAVVPGLLEVTTQHVYFYDGSAERVETEEGIGHDFRRPLAQLREVHLRRFNLRRSALELFFIDQANYFLNFPCKVGGPTASSPYQGPRPQPCPIPPHTQVRNQVYSWLLRLRPPTQGYLSSRSPQEMLRASGLTQKWVQREISNFEYLMQLNTIAGRTYNDLSQYPVVRSCPLPPPHPAGLPALLHPSVGVDGGPSPELGPRRVLPETWFLFPAVPPHTQPHSPPLLASVFPGGTPDPDSPSGSPATPPRGAPSPVGSALLPEGQGGQVDPQDSHVAPTRVGGQFPWVLQDYVSPTLDLSNPAVFRDLSKPIGVVNPKHAQLVREKYESFEDPAGTIDKFHYGTHYSNAAGVMHYLIRVEPFTSLHVQLQSGRFDCSDRQFHSVAAAWQARLESPADVKELIPEFFYFPDFLENQNGFDLGCLQLTNEKVGDVVLPPWASSPEDFIQQHRRALESEYVSAHLHEWIDLIFGYKQRGPAAEEALNVFYYCTYEGAVDLDQVADERERKALEGIISNFGQTPCQLLKEPHPSRLSAEEAAQRLARVDTNSPSIFQHLNQLKAFFAEVISDDVPLVLAMVPHQQPHSFITQGSPDLLVTVSANGMLGTHNWLPYDRNISNYFSFSKDPTIGNPKMQRLLSGPWVPGSGVSGQALAVAPDGRLLFSGGHWDGSLRVTALPRGKLLNQLRRHLDVVTCLALDTCGIYLISGSRDTTCMVWRLLQQGGLSVGLASKPVQVLYGHEAAVSCVAISTELDMAVSGSEDGTVIIHTVRRGHFVATLRPPGATLPGPVAHLALGSEGQIVVQSSARERLGAQVTYSLHLYSVNGRLRASLTLGEQPTALKVTEDFVLLGTAQCALHILHLNKLLPAVPPLPMKVPIRSVAVTKERSHVLVGLEDGKLIVVGAGQPSEVRSSQFARKLWRSSRRISQVSSGETEYNPGEAR
The following text describes a protein:
Function:
Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine. L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator. May also act on O-phospho-D-serine.
Sequence:
MISHSELRKLFYSADAVCFDVDSTVISEEGIGELAKICGVEDAVSEMTWRAMGGAVSFKVALTEHLAPIQPSREQVQRLIAEHPPHLTPSISKRSRCSSRLQERNVQVFLISGGFRSIVEHVASKLNIPATNVFASRLKFYFNGKMSGVRDHPGQRGEAPTLLKKKKKKKKIGKLDAFIGFGGNVIRQQVKDNAKWYITDFVELLGEPKE
The following text describes a protein:
Function:
Sugar-1-kinase with a strict substrate specificity for D-glucuronic acid and ATP. Involved in the biosynthesis of UDP-glucuronic acid (UDP-GlcA), providing nucleotide sugars for cell-wall polymers. May be also involved in a salvage pathway for glucuronic acid.
Sequence:
MASSGPIEHRAYARVGLFGNPSDVYYGRTISFSLGNFWAGVLLEPSEKLVIQPHPIHDLVEFESIDRLVGRVQNGGFYGGVRLLMAICKIFFNHCVDKGIALHGGNFTLSYDTNIPRQAGLSGSSAIVCATLNCLLDFYKVRHLIKVEIRPNLILNAEKELGIVAGLQDRVTQVYGGLVYMDFSKEHMDKLGHGLYTPMDRSILPPFYLIYAENPSDSGKVHSTVQKRWLDGDPLIISSMEEVANIALQGREALLKKDNDKLAELMNRNFDLRRRTRIKRKKINRDELTEFLAWCRLMFGDEALGSLNISMVEVARSVGAAAKFTGSGGAVIALCPKGPSQAEDLKVACQKAGFIVQQAVVVSSFLSDEEPKVAASS
The following text describes a protein:
Function:
Probable ATP-dependent zinc metallopeptidase.
Sequence:
MRSGGALLATAGLASQAAKNLVAAAAAPSAPAFRASAANTPSGAGSMLRNLQQRYWSSFVGQRARGVHSGAAAFLSKEIHRSGPERVTQNFKTLNQGISSAAREEGHVLGTASAPQYTVEKDLLKKQLLRTISALTVTGFAIYGVKLMLDSAIDTKVSKFDGLKEVLATDLSTRFSDVKGVDEAKAELEDIVHYLRDPDSFKRLGGKLPKGVLLVGQPGTGKTMLARSVAGEAGVPFFSCSGSDFEEMYVGVGARRVRELFSAAKKRSPCIVFIDEIDAIGGRRDTEGLTSQRPALNQLLVEMDGFKQNDGIIVIAATTLPQSLDSALVRPGRFDCQVHVSVPDVEGRRQILEAYMSKVSKSKDVDAMTIARGTPGFSGAALANLVNTAALKASRDGANAVGMGHLEYAMDRIIMGRERKSMVISDLSKKRTAYHEAGHALVAILTDGANTVHKATIVPMGNALGKVTQLPGEDSHLTRKQMLARLDVAMGGRVADELIFGEAGITTGASSDLSKATRYAKDMVVKYGMSKRVGLVSYGNDINAARGKAMAMSGRTIGLVDEEVKALLDNAYRNAKKILTEHNKEFHALANALMEHETLTGDQIKKLVLTGRQGDGRSNSQQNQGTPSLTGDQIKKRVSTGRHGDRRSNSQQNQGTPSLTDDQIKKRVSTGRQGDDRSSSQQNQVTPPLAGDEITKLVSTDQQVDGHNNSRQDQGTSSLSSDESTKSISTEQPGDGPNSSKHNQGAPSIAGEEATKLVSTEKQADCYSGSQWDQGTPSLTRNEDANQ