lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase.
Subcellular Localization:
Nucleus.
Sequence:
MTSLPEKDQQGEVSVSENQKKLSEEWEPYIDKLVASNRTRDERVESIQELFQKCVIEEKLPVDIFFSIFSLAFERLEEKNTLASYVIDTLWLFDTEWIKNFHEGSHDKAEKRLVSIGKGLKEFLPEEWLLSRLDCKFLENINVVPNGDFLNRKIVRTNTSLLYRQKKFNLLREESEGFSHLMINFFDALTCLRNKSLNEDYLIVQVNKSIISTIGAFDLDPNKVLDLILLLFSENLLDSWRFFLSILRNSPWGPNKERKFWNQLPDREKETFLNNLSNANGIFNFDERFTNTKSIMSQVLGHNLQYMYKEDDENLESYFMMVALLIKYNFISIDNIWAHLSPSDEELGKELGKYKDKLDEQTFKAKGNALTMAAPLPDDEIEDGETMDGQKAEAVPEIKKAKPSQKLGLLKSLLSIGDLSSSLLILGRYPFLLRAYPELSNLYHKLLHISISSIYANYSPLKLLPNDVRERLKQPKFIPEDSRLREITLRPPKEKNLVFSLDPFADRFNKTESEVFYYFENYDEDIPILRNLTEFYNIAIPWLRLSGLALCHDPVIVTKLCRIGQKCVDNSSESRTLWLDIIRSLLLPLITLIDVNTGLSYELFELLSKFDSSTRYALYGEWSSTSMKKFPELKLQNSITEKETKGILRRLTKTNVKQFGRLLAKVCHSNPCTVFSIALNQIETYDNLVEVVVDSARFITALDFDALTFIILSSFSNEFKKRLKSDGTSIAHWLQGLASFCGRVFRRYSSLDCTSIVEYVIKQFKVNQMFDLVILKELLSQMTGLQPWTNLSDNQIQGAAGGPVLRQLSLSLIYENPDVVRKSSMRLFNTLQKNGLATQLLVLLSQKYSTCIYDVTDENSHLKLISSLQDECSDVLYLLMEFLNMVCSPKSYYKLIPSFEQLIQDFHIQPQVAFYLSRYKNLDHSLTGSNTEDAMDIDYENTSSPNTASNPVWSIDNSVITELLPKQIWDYFSPNFYLTFWKLSLYDVFVPLERYEFERSRAFDQIRQTDAANTFYSRHRHDRQKIMQLSNSLQNELKEHINSLESVRKVLQGDCVKWFIPNGVFPNGTRLEHARFNCARYLWTLCIAPRLKMSPHDALYCAKFVKLLHSLGTPNFSTMSFLEILFNSQLPSFIFSMTQREADNFGRFLYEVLYDITSWYRDKILYERECLANGALPGFRLYWSDEQNDPDLSAVLPYNKFVLLFSKWHKYLTSYFESCLLSTEYMHIYNSVIILEKILPCFPLIIESGSALKRAAERLKDEEKREDLKVLALGYFAKLSKKQPEWVSFNSFSGTVRPSNSEKLQRPQQLSVAATSAVDSKTASISEEQAKIDKQKVALNPSAPEFVPDSTPSDAVASETDNKNLVENKAVEKRVEARSSANERKQEERRRKTTPEGNRRALRTRTPTNEDIQRSDSKLREDQSRDRTPQSRSFTNENNDNLRSVSRHTRREPQQAQNLNARREHESQKSDRWRQNGNVNRNPRVSNNNSTNVSRERSSEANHRTSNDNKRDEVTEGKDKNKRQDISGESNSRQNNAISRAGRSNGSNRGNDSRDADGRRSTHYASNKRPRSSDSQSPSNLREEDERENSRRRARQDDRRDRDSRQQRDRPRDRTSRSAREEKRRKIQ
The following text describes a protein:
Function:
Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia.
Subcellular Localization:
Apical cell membrane; Lipid-anchor, GPI-anchor. Basolateral cell membrane; Lipid-anchor, GPI-anchor. Cell projection, cilium membrane. Secreted.
Sequence:
MAYLFHLAVALLVSQLTTAQWTEGPHYTSVTAGRTCRAKELTPFTLVKGYIASWMYSTSIGNLLNRITNRFPCGIRQYTSVSIKSADISEYITQTKEDFISQISYSDYSSCGYYYYGPETYCNQSLLYGLKEALLISPPGSFVLVITDGTISDANDTALLNGIYSLLEEKQSQVFFMYWDWHWPPKESQDSLLQSIASRSYGHVSSIYLYGIWEAMYGLDFFLTKPVNASVRILNINVNASGEIKETFNTTALTHLLVYTTGDVNITLTDPNGNGADIVRSLIYSPGNAYLVKHSVSGKWTLSLNCNGFISVMILGFTGSSQIGKCSDSDCHPNATCEEFGGDQECTCKNGFTGDGFQCYDVNECDDYWLTKCNGYCENTVGSYNCTCYSGLKYTEEGCVDIDECASKDLNDCHPLAVCNNYWGWYSCSCPYGYFGDGYFCEVNECQQGTPCDPNTDCIKYKGLYICLDPCSNHTVLDEPWRSLDNKHSDYYYYYDYYWYHCDYGLSGWYHFQGKTDQKIPEYCIAQQSCGTNIPIWLNGTHPKEKEGIVNRTACFNWGDCCSWNSSVSIKACPGDFYVYKLTGTPFCNSAFCVEPNLKTLNCSSLYCSHDEECRKENGVVGCYCKHSDNIYGDVHEDFPIPELTCRTSLMRLSYSKCLLEKMGMNASTVHLRDNGCQGYIEREDIQMVKIDMLPRKGFCGGQIKVNTTHFTYINTVYVSPKSDEMIQRGEIALEVSCSYARNMEVSLWTAINPIISSLNISVGGTGSYTAKMSLFQNWDYSMPFQGPEIWLSTETLIYVGVMVEEMNEPQFVLQMKDCYATPTRDSQHPVKYYIIKNNCPNVNDPTIFMEENGQSLNGRFSVQLFKLIGYDTIFLHCQISLCDTSTEICNPHCRVKSASIDDNYATQNLTLGPIHNRGAVIQPAKPPEAHISNGAAPPALTLTSILFFLVLIFVC
The following text describes a protein:
Function:
Acetyltransferase which mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC) (By similarity). Has a calcium-independent activity (By similarity). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in the regulation of lipid droplet number and size.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Lipid droplet.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine.
Sequence:
MTTSTIKPTGGDEVPPAGVVGNVADVGVAASLTKRDSEEDTWASKGYNYINPFVHRIEIDSHIEVAKIYVLTVLLLPIRVVGCVLSLISAWMFACIGLYGMTLDDLKAKPLTGWRKQMQYMTACGMRMVYTFGSFHYVTMKGRAATAKEAPILVVAPHSSYVDSILVVASGPPSIVAKRETADIPLLGKIINYAQPIYVQREDPNSRQNTIRDIVDRARSTDDWPQVVIFAEGTCTNRTALIKFKPGAFYPGVPVQPVLLKYPNKYDTFTWTWDGPGVLRLLWLTMTQFYNRCEIEYLPVYTPSEDEVADANLYANNVREVMAKALGVPTSDYSFEDVIVMSRARDMKIPFPGDIVEIERTIEKLGLNESQRDAELCKGFLRLSNTDRLDIITFGELLQVDLKNTDLHKLFALLDHRRSGTVSLKSFLLCSLFCKLKNSDLLTFLRALIHLYSESSQQIDRESFVRLMRHAGGKLNEQKAQALFYALDTDNLGYVSFDSFVELTEKQKSSYKFLYHKSEHIRRPKAVVTTAEN
The following text describes a protein:
Function:
Transcriptional regulator that regulates arginine biosynthesis, by repression. Additionally represses many other genes including those involved in pyrimidine biosynthesis; nitrogen metabolism and nitrate utilization; antibiotic production; osmotic stress protector ectoine; genes related to hydrophobic cover formation and sporulation; glycan cell wall biosynthesis; gas vesicle formation and genes involved in secretion as well as genes for membrane proteins. Has a weak activating function on some genes.
Subcellular Localization:
Cytoplasm.
Sequence:
MSHAQEHEQPAGPALPQTRTARHRRIVDILNRQAVRSQSQLAKLLADDGLTVTQATLSRDLDELNAVKIRNTDGDLIYAVPSEGGFRTPRAPLGESAKEERMRRLSAELLISAEASANLVVLRTPPGAAQFLASAIDQAELHDILGTIAGDDTLMLISREPTGGQALADHLLRLAQNGG
The following text describes a protein:
Function:
Probable transcription factor (Probable). Important for development and migration of oligodendrocyte precursor cells, and normal myelination of axons in the central nervous system (CNS). Functions autonomously in oligodendrocytes to promote CNS myelination. Seems to act in parallel with notch3 during oligodendrocyte development.
Subcellular Localization:
Nucleus.
Sequence:
MSRKRNHCYMETGASSESQGAFVDSAGPFSRDEEDFSELEPDEQLVCSVTEITEHLGRNITVVLESALSEIRKLVGVRIRVLKMELREKSDEIELLKAKLESAEKDGRVSNFSSLDFRKSEHQKYGAEPKKAKTGTPVVKKENINAICDYLMKDKNQRGAAEVESDHSNQAFGSERDVRTEAQPHGSLSLWPDSGPADTDAETDIFSMLPSASKRMYDYEWMTGVELNSAEFKGDSETKCEDVPPMDEEDENEDSEEGRGSLRSVSDHFPLDTQGSPGEDRSSPAEDSMDRMEPGQQFTSHTFICPFCGTLCPDSSFLEEHIKLMHHGESLLQSTSAGSSSQAEGDSGEAGPASRGAREKKVEGGYECGDCGRHFNYLGNLRQHQRIHTGEKPFVCPECGERFRHTARLKSHRLSHSGAQSPFPCPQCGKGFPVLSGLKRHQRVHTGESPYACPQCGRRFKELGNLYTHMRIHSGATPYTCYQCGRSFRHLGTYKSHRCMPATQMPSEHSPPWAQEDKVQTGRLQGYV
The following text describes a protein:
Function:
Proton-associated sucrose transporter. May be able to transport also glucose and fructose.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKMAPQNADPESMQVQELSVPLPDPQKAGGAEAENCETISEGSIDRIPVRLWVMHGAVMFGREFCYAMETALVTPILLQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVLFGVALFLNGSAIGLALGDVPNRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLDWTQTFLGSWFRTQNQVLFFFAAIIFTVSVALHLFSIEEEQYSPQQERSTEEPGALDEGELHSIPAFPDEVQSEHELALDYLDVDIVRSKSDSALHVPDSALDLEPELLFLHGIEPSIFHDASYPATPSSTSQELPKTKLPRLVTFLKEAAKEDETLLDNHLNEAKVPNGSGSPTKDALGGYSRVDMKPLATSGSVRRRRHAFRRQASSTFSYYGKLGSHCYRYRRANAVVLIKPSRSMSDLYDMQKRQRQRHRHRNQSGATTSSGDTESEEGEGETTVRLLWLSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGDPKASSNSTTWQAYNAGVKMGCWGLVIYAATGAICSALLQKYLDNYDLSVRVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDIKQYVHHSPGNSKRGFGIDCAILSCQVYISQILVASALGGVVDAVGTVRVIPMVASVGSFLGFLTATFLVIYPDVSEEAKEEQKGLSSQLASEGGAGGSSEKPTALKLTRKEGLQGLVETESVTPAGIDVCQVSSRWLVPQLLESLFLYDYFRKKIFFSAMWFS
The following text describes a protein:
Function:
Forms chloride channels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane.
Sequence:
MTVSYSFDVSRNSWFVPLKVLCRWRGSVWKSVWRELLFWLVLYYIVMAVYRSDYILGPNGQKTFELLCVYLRSHSEWIPLNILLGFFVSMVLARWRQMFLNLGFIENTAHAIATLFKHVDEEDLFLRRSLVRYLCLSQLMVFRDISLKVRKRFPNLDSIVKAGFMEEEERVLYENVNTKFNKYWIPFNWACSLAMKARQTGKLNGDNYLSNFFQELKNYRNSLQLLSNFDWIPVPLAYPQLVICIVRVYFLLCVVSRQFIVGKEAINKSVIDLGFPLMTVLQFLFYVGWMKVAESLLNPMGEDDDHFELNYLIDRNIETGLLIVDDTFGVIPPLKMDRFKNESKPMYTEESAPKGSDAYAGFNGSVAHIILAHEAESVPMKRICTDELSQSRASVAPSLPGKIGMTMRRRFSRGSSRCGGTTPVQQVPQIIVTSTSGQAPLTRARVDSITRKRDLNRADSFGDSIDTTDFANPFMNSTASENVRRYIASTNRRNSMLDVVSEETNLSRPDSGSSSSPSSHQKVCVCEEILEPFADDFSMWGSARNLQLLDTAPQPFSCSTLSHSVPSLLTPPPIPAQPASSPNMTTAPKSILKKRSREWDPSVHGDSGIRSEPASRDSRILPIVEEEPSVAEAVRCLLMKKLGVIDRDLLDSSLTSLCKNDSLRSQDDDDKEDPIEFRKKISSISEQYPFNKPLHLRPDSEGAK
The following text describes a protein:
Function:
Immune regulatory cytokine.
Subcellular Localization:
Secreted.
Sequence:
MRGFRLAFGLFSVVGFLLWTPLTGLKTLHLGSCVITANLQAIQKEFSEIRHSVQAEDENIDVRILRTTESLKDTKLSDRCCFLRHLVRFYLDRVFKVYQTPDHHTLRKISSLANSFLIIKKDLSVCHSHMACHCGEEAMEKYNQILSHFTELELQAAVVKALGELGILLRWMKQML
The following text describes a protein:
Function:
Serine and threonine phosphatase. Involved in tRNA splicing and cell separation.
Miscellaneous:
MISCELLANEOUS: Present with 1520 molecules/cell in log phase SD medium.
Subcellular Localization:
Peroxisome. Note=Peroxisomal localization is dependent on PEX5.
Sequence:
MSNHSEILERPETPYDITYRVGVAENKNSKFRRTMEDVHTYVKNFASRLDWGYFAVFDGHAGIQASKWCGKHLHTIIEQNILADETRDVRDVLNDSFLAIDEEINTKLVGNSGCTAAVCVLRWELPDSVSDDSMDLAQHQRKLYTANVGDSRIVLFRNGNSIRLTYDHKASDTLEMQRVEQAGGLIMKSRVNGMLAVTRSLGDKFFDSLVVGSPFTTSVEITSEDKFLILACDGLWDVIDDQDACELIKDITEPNEAAKVLVRYALENGTTDNVTVMVVFL
The following text describes a protein:
Function:
Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Required for the metaphase to anaphase transition in meiosis.
Sequence:
MQKAAPRPIIKRSYLNLDAIFGHVFSNLTGEPVTPTKIATFYLLRILFQTHFGFRHKRAYYKPFSPAEKERIFHWLYALMTSVVELSYKDFRIVTRLAFDDGREVCKNFYAAMEKIGAGMADVTLNVEDEFYTNKHPKDPKLPANDTVHEAMDLARGDIIQFSSNHSFMYRWMKRLLAQYTKSTPSEVFQINAAMKSWVLSAVESKYHPEFKGEYLPHFIDCSVRARDWVAKSIYFIQKNPRFAFQYNEMLHYTRIVQKRHPDVVEGFLLEAIVQVQLKDSSSAIKAMKSFFELSMFELNENMVHAAKTHRLAVPTQTPLMYAPILQARICRIFGDYQMARLLLHESLQQAQLRNDEICHQMANIEMHTVDILGCRALLEDNNEKTAKHIENERRVQRKALLHIDDLHGHTRSGPCCLSSEEDFELVAEMDSYGKMLMLMKIIAEGNYKLIYDRVAETGITCPVGNDLGERGRKVAAYGAALISSNMIHNGMYHQAKCAAENMLANNCRTDETDPFQAPFQAEPWAIGAVNLSYSQAGVGNYDAALRTIEEMRQNYPEELSWQSNRHVVICAAVINFERFLLKNDYKACASEVLNLAAHSELECKLRQALLLAAAGKERASVEVLEGLNVVDIRGRIRIHMQTGCIYTASQEFRKAAREFADALSLAENTTLKDIVPMVKRRQATMLMCHGQYVECLKLLKECNEGIEQFGSFTEKACYYMTAARCHRLLGKDPRMWLKKSRALVRNGQWPAFTKLVLSEIAALHDVKGLMPDENRLSQICEQFGKLTADCPGRCEWLLI
The following text describes a protein:
Function:
Probable transcriptional regulator.
Subcellular Localization:
Nucleus.
Domain:
The methyl-CpG-binding domain (MBD) functions both in binding to methylated DNA and in protein interactions.
Sequence:
MNGEGISDGLSAERKVEIRVRKNGRKDKVIVEKSAAQGLPEGWIKKLEITNRSGRKTRRDPFFIDPKSEYIFQSFKDASRYVETGNIGHYARKLKESDIEDDDSGNGKTVLRLEYVDKRSADDVLEKEKTIDDVRRSKRRNLSSSDEHSKNCKMTSDLSIVTSQVLEDLGKKEEVKDPIEKQLIAKRVTRSQTKASTTEEVVVDLKRNLSSSNAKSEKDSVNSSVRSQKPKKEAVMKEEEEQDSSEKRITRSKVEEKKNELSNSVARRTSKRLAGIELEPTPELKTRAKVQRIVPLDDEPTPELKTRTKVQRVVPPDDEPTPELKTRTKIQRIVPPDDEPTLELKTRTKVQRILPPDDELTPELKSRTKVQRIVPPDDELTPEFKTRTKVQQRIPPDDGRAGKCKQPVNHVTTSGSKKTEIPLNKEVAQSCNEQSSQKPHAAAATSNNRVSADSAVGIQNIGKAVGRKPSKDKKTLKSPLIVYELNPVFHLDGYKQKEEMSPVSPLSCQTSATKCEKTAAGKRVGRSSPKANLTTSVKPTQISPLRSPNKGKQPHPSDSGSAIQRRNKLANEYSNSSVVRGTCSEVMEKSTNSFSSAFDSTLADLCKDPCIAFAIKTLTGESLCLLNTPAISSNPINNHTKQKGVSFTPETPGNVNTCSEKLVFPSPPPGANIWQDPCIDFAIKTLTGAIPIGLDEPDTKSKSQGMTSTTAATQEAKGRQNNCDYMTNKTVGKPDDLRFTQSFSKD
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVTRGRADASSETIPLQALCLVEMDMIWWFRWWHNNTPVVRQSLYNKINPEHSWNTYGSTPRVTRVHHQFQGKPGNPPARRHDSDIIVKPVWLNDRTQVSVVVDLLNTVKVSAIIGPETYIGSKLVTDETKVPIFTFAGKSSMQHPYLFQIIEDEFAMTQGIAALVQLFKWRDLIFVYEDTDHEHNILEHLFESFQDKNIRITYRSAISASATNDQVIEELRKLMSIQTTIVIVHVSPSLASSIFLNAKMLGMMSKEYAWILTPKTIEIMHSTEFQVIESLQGAIGFRPYIPMSSKMHDLSKRWRNGSSRELPTLAIWAYDTVWALAESIEKVGAGSMILSEIVNIEFKGASGEFRLSGNKLVSNGFEIINAVDHGERKVGHWTVSNGIRRAHLPLHDAAPHSSSNIEDVIWPGGSTVTPKGWISRMNVGKTLRIGVRTGPSFNYFADAYYDAQKNRTTATGFSVDVFNTCLHALPYEVSYELVPFASGSYDDLINKVYNQQLDGVLGDSTILASRSQYVDFTATYTDVGIGTLIRIKERDSWPWGFLKRFDADLWLTYAVFGILAILSVWAIPAVNQFEHERRLAQQIKTIAVLVLLSIFFAQRRRLLKYLSVSVMIVWFGLVAFLFKQSYRATQASLTSVEKVELALKQGVVGFHGGSLFGDLKLSYNMKNSYHSYEDYDDALSRGGKHGGADAIVDEVPYIKMFLRRYPHDYAMVLSKPITSGFGFIFAKGSPLVIEMSREIAKIREDGTLMKLEMEWFGKDFSLAFPTMVEPPNLVRFWGLFIVIGVSLALALMVLALYLVRARMDLETIITFLVGQSLVATTVNLWVKISNRAGRADFYLQDRLIRLYNFFNE
The following text describes a protein:
Function:
Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localized in the cytoplasm at the primary oocyte stage and in oocytes within mono-laminar follicles. Expressed in the nucleus and cytoplasm of oocytes in bi-laminar and Graafian follicles and during the 2-cell and morula stages. In 3.5 dpc blastocysts localization is mainly nuclear. Mainly localizes in the female pronucleus, localization to the male pronucleus in much weaker.
Domain:
Mediates binding to H3K9me2 via N-terminal region, while ability to exclude TET3 from the maternal pronucleus requires the C-terminal part.
Sequence:
MEEPSEKVDPMKDPETPQKKDEEDALDDTDVLQPETLVKVMKKLTLNPGVKRSARRRSLRNRIAAVPVENKSEKIRREVQSAFPKRRVRTLLSVLKDPIAKMRRLVRIEQRQKRLEGNEFERDSEPFRCLCTFCHYQRWDPSENAKIGKN
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the ubiquitin conjugating enzyme UBE2J1. Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING. Also required to limit type I interferon response by promoting autophagic degradation of IRF3.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MQGIILFLNGLGWTLDMLFLLLDLNYMLVSSVVSVLCWTICFIFNLPWTLTNGILQLWEAVLGFVLMVGDSSCSLALGTVQTLVDALWGCLAGLDSLKLIWNLLCHLLFRSRELIHRGLLNITFSVQTFHRNFWEALSITGGLAAYLVNSLVNICLIAIQNILSAAVALWLSMVNVILMGAELMFMLLSQFSNSAVAVAILLWTPCQLILDGFASLSRGVGIIFYQHLYKILIFLLLAIICRIIFRPSPAVRQFQLKVIQIYRMALVLAWSLLHCEVLRRVIAKSAQIIRMFRIYGATLVRGWNLRRTRIQNPPARPATVQNPARIRERNQVPMREQNPPLRPIQSTVPNRVQNTQPATHIPQASSAFTKRGEPSQDPWKLLKQQEESKKCVICQDENKTVLLLPCRHLCLCASCTEILLQQPVHQRNCPLCRQMILQTLNVYI
The following text describes a protein:
Function:
May be involved in DNA replication and thus regulate cell proliferation.
Sequence:
MLKTSVAPNELHLKRELVALRKAPFLRDPETCSSWRSSLSSKSFFANSKPKNGHGMIEKFTGEINHGSLLNLLSRGKNGRQKLHLCSMSSSKPIERAQKLDEEDREESAKESPENFSVSNSLLAEESPENFSLSSSLIVDSKSDTCLEVPVNMYNVAAIDSRIPVRRTIRKFRRKSISKGGLIKHSAALKLLDTTSSSLGILDSIEGSDDSGDYNSENLQHLAQDLSQKIGFISRSASPILHGCGHGCQLSSSRIPRTSKRVGSSQSCTPASSCSYYKYGGQDPSTIGSWDGTATSFDGDGLDQLELPKAQKCGIPSYWSKITRARGGGGFISPSLSDTLKRKGSSILCGSQTLSNKKNLSGCHKQNYLSKSSQGLPLLTNSCDEGHSSLDTSSDELSSKFGELDLEAMSRLNGRRWSSCKSQEGLEMDLPGRTSLEIADQRTLSQKYQPRSFHEIVGQNIVVQSLGNAISRGKIAPAYLFHGPRGTGKTSSARIFAAALNCLSEENKPCWFCRECTAFSSRHGTNFIEANATNKMCIDQVRYLLKSLSMAKTISQYKVFVIDECHMLSSQNWSAFMKFLEEPLPRVVFIFITTGTGSLPRAIVSRCQKYIFLKVKDVDIVCRLRTLSVKENLDIELDALDLIALNSDGSLRDAEIMLDQLSLLGKRITTSLVNDLVGVVPDEKLLDLLEIAMSSDTAETVKRSRELINSGVDPIALMSQLAGLIMDIIAGTYRLADLHSGGTTLGGRNLTEAELERLQLALKILSDAEKQLRHSSERSTWFTAALLQLGSGNNTEPNRSSSSSRQSARRKSNGVSDMDSLSMMHKNRQVTQFQEYNFCFISYTNNIYSNPYIDSAYMANCKVLPANRRSLDRILDNFSHTSDATGKGELRSMTPEMLNEIWNLCIHRCHSNTLRQLLSANGRLLSISENGGILIAFIGFEDSVTKSRAERFLSSITNSMEIVLGYNVEVRMALLPKVHSDVLQSEPSLASNQMEKDKQREARSDNLISHPNIGKIKGSKILDSCEGNPESAHEKTDISALGEMDYVQTSVPVLDGSCNSNDKGQGILAQRPLKAATDEQRLETAWLQTAEPGYVSQPKPDKNQILPQNGVNHLSSKQSLTTTPKSLKNWDDELVQGIKALRTSATEGHHKEQYERADHYAISPSLLHCYKTGNSEKQKMGYESGPGCNGILCWKNPKSRGRKVKQGIHLRSPRVSRAHRLSLFGQCVKLKSAEDRLSK
The following text describes a protein:
Function:
Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
Sequence:
MNDSSLDYLKKALSLAEIRRGFCAPNPSVGAVVVKDDKIISTGFHKRSGLPHAEVEAIKSLGDKARGAALYVTLEPCCHFGKTPPCTDLIIQSGIKAVYYGLHDPNLAVCGKGIEQLQRAGVNCFLIELPEINAFYESYRYWIKHKRPWVTAKLALSLDGKIVGNEGKPVRLTGEGLRQYTHERRKKSDALLTTINTILTDDPKLNVRLQGEEIKKPIYILDTHLRLPLNALIHQTAESIIVFHGNEADKKQQQRLMQKNIRCIEIARRSEGLDLNEVLDVIGNDGIHDLWIEAGGTCFQSFLKENLINRALIYIAPKILGSTAMPAFQLPFSFSGYSVEWRQFGEDVMGEIRF
The following text describes a protein:
Function:
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling.
Sequence:
NNRRAHHRGIVDECCFQSCDFRRLEMYCAPAKPAKSARSVRAQR
The following text describes a protein:
Function:
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Sequence:
MNVLNKEVFNQTKKVLGLIVSNKLVNGFSKQFKSYMFQSPKFKPIVSTDNDDKKMIYLCDTLKKETDIPDQLKTFIKENDIKVIEKDISLNYNNFSYEQVLKTLLPKDVGIPFSFERIGHIIHVNLKDEQLPFKYIIGQAILDKNIQVKTVLNKVGEIDTVFRTFKIEILAGEPDLVAEIKENECIFRFNFEEVYWNSRLQYEHMELVNTFKKEDIICDMFAGVGPFALPAAKIKKCKVYANDLNPSSVKYMKENAKTNRLESKVEISNLDARDFVKSLVEKSIPFTHVVMNLPSTSIEFLDVFRDIFLNSTIPPPIPPPIINCYTFTKLDESSDLIKDTIKNVENVIGAKVPSDYVCYEVRDVAPKKSMMRITFRMPTILPYVGSLTTASTTTTPTTSNTNTSTTTSTTSTSTTTTESTNTNNSANNVEDKNNKKRNSTEDSNETNETDSIDTNKKLKN
The following text describes a protein:
Function:
When phosphorylated, plays a role in filament reorganization.
Sequence:
MKCSLECVFFPPKIVNFTISLLPSGLDSSSSYSMRPAGSIRTTQMMVKRSVPLSSSASVYGGAGGRGSRISLGGSSGFGGGFQSGGSFSSSVSMSGSGVITNEKETMQHLNDRLASYLETVRNLEQANSKLELQIREALEKRGPAARDYSNYDNILDDLRKKVFDMTVDNARLVLQIDNARLAADDFRVKFESELAIRQSVEADIAGLRKVIDDTNIGRMNLESEIEALKEELVHLKKNHDNDVLELRNQVSQSGVQVDVDAPKGQDLAQIMAEMRAKYEKMAQKNQEELKAWHETQITEVQVQMSQNTEALQGARTEVTELRRQYQALEIELESQRSLKASLEGTLRDTELRYNMEMEKYNTIIMQLEGELGQLRNNIQQQAQEYEALLNIKMKLEAEIATYRRLLDGGDFRLQDALEDQKTIKTKVTVTQMVDGKVVSQSSDTKEIKS
The following text describes a protein:
Function:
Involved in assembly of the mitochondrial F1-F0 complex.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MAYNYLKNLVIPRLIVKHQFKLRSFSTKSLNDTKEKAPSALIPVGLLVKPTMLSEVQKPTLWEKLTKPASTSSPEQRQKELLNEMKRSTIQDFNEVRRFNGKLFYSPPRLFKEKSALWMYNFHGKSLRNQYKELYKDWQGSPFFFALFSNAFGENQCRNWIQHLAPFDYLPVRYANVQSNLIKYWLQKIFIGKVKRSIPEKCWNEYITAYDNKFSFPEIGWNNKLVGNVYLIDDSCKIRWLGTGDPTNVEIENLKTAIKFLVNKNVG
The following text describes a protein:
Function:
Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier ufm-1 to substrate proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MDPLLLGSVGVLVLAVTLIIWRLLKLQWDEKAARQRTDMLLAMNEGAGGSDERRGANVAGGMRRNARRRVNRDEQEDGFVNHMMNDGEDVEDLDGGAEQFEYDEDGKKIGKRKAAKLQAKEEKRQMREYEVREREERKRREEEREKKRDEERAKEEADEKAEEERLRKEREEKERKEHEEYLAMKASFAIEEEGTDAIEGEEAENLIRDFVDYVKTNKVVNIDELSSHFGLKSEDAVNRLQHFIEEGLVQGVMDDRGKFIYISDEEFAAVAKFINQRGRVSIHEIAEQSNRLIRLETPSAAE
The following text describes a protein:
Function:
Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates.
Subcellular Localization:
Secreted.
Sequence:
MSNKKLILKLFICSTIFITFVFALHDKQVVAASSVNELENWSKWMQPIPDNIPLARISIPGTHDSGTFKLQNPIKQVWGMTQEYDFRYQMDHGARIFDIRGRLTDDNTIVLHHGPLYLYVTLHEFINEAKQFLRDNPSETIIMSLKKEYEDMKGAEDSFSSTFEKNYFVDPIFLKTEGNIKLGDARGKIVLLKRYSGSNESGGYNNFYWPDNETFTTTVNQNVNVTVQDKYKVSYDEKVKSIKDTMNETMNNSEDLNHLYINFTSLSSGGTAWNSPYYYASYINPEIANHIKQKNPARVGWVIQDYINEKWSPLLYQEVIRANKSLIKE
The following text describes a protein:
Function:
Catalyzes the transfer of CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (By similarity). Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development (Probable).
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein. Cytoplasm. Nucleus. Endoplasmic reticulum. Note=In retinal tissue, does not localize with the Golgi apparatus.
Sequence:
MSRINKNVVLALLTLTSSAFLLFQLYYYKHYLSARNGPGSSKSKGNRVGFDSTQWRAVKKFIMLTSSQNVPVFLIDPWILESINKNFEQVKNASQGPASECRFFCVPRDFTAFALQYHLWKNEDGWFRIAENMGFQCLKTESKDPRLDGIDSLSGTEIPLHYVCKLTTHAIHLVVFHERSGNYLWHGHLRLKGHMDRKFVPFRKLQFGRYPGAFDRPELQQVTVDGLDMLIPKDPGRFLEEVPHSRFIECRYKEARAFLQQYIDDNTVDAMVFRKRAKELLQLAAKTLKDLGVPFWLSSGTCLGWYRQCGIIPYSKDVDLGIFIQDYKPDIILAFQEAGLPLKHKFGKVEDSLELSFQGKNDVKLDIFFFYEEADHLWNGGTQARTGKKFKYLFPKFTLCWTEFVDIKVHVPCETVDYIEANYGKTWKIPIKTWDWKSSPPNVQPNGIWPISEWDEVIQLY