lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
Sequence:
MMSSTPTPFISCRGTHGVQVFEGTHFQPVEEFKNESSKTCRLAMWSPDGKYLAWANGTVVSVAETEKWSVIATFPKPKTSGLQFSPKGNFLVTWEPYQVTKDIPVNTPNLHIWNLQTKQSVKSYVQKNHSKWEPYWSKDEKLLSRNLNLELQVYEVDKMDSISQRSDASLKISDYSTSPGYSPYFFLCYIQGSKGQPSFAKLFKYPNLNPSGLVASKSFFQGDRVEMKWSKPGNCVLLMTSTDVDTSGASYYGKQTLHFLDVKGTSAMVQLPRDGPIYSVEWNPNGTEFCVVYGFMPAKATLYDLKCEAKFDFGTGPRNSSFYNPLGNILLLGGFGNLQGKIEIWDTQTLKLISPMDAPDTTHLQWSPDGQHFMTSTTAPRLRVSNGFKIWHYSGGLLFEHNIQSPNELWEATWQPMPDGYLKDFKVSTKKVAGIKPSQPQVSKELYRPPGARGTSAILKFLEEREAPSNPKAVKPVEKGPSQVKPNKRNERKIKKAAAEKSSVPVESSPPIDTTGITSDVQFELTGDETTDKKLKDLKKKLDQIARLKAEQSAGKKLEVNQVEKIQKESELTKQLMELSLKKK
The following text describes a protein:
Function:
Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
Subcellular Localization:
Cytoplasm.
Sequence:
MDPLAGLTTGSRNVIDDFFRWSRLSLDKFKRDLTVEASAFQAGNLWREQYTKAEVAQMLNGQLALMLGVVDTQMEGTTAASAELMRAVLREADRQRVTLDIDVKSVLNNAGGVNAMGEHGRQLMSGPTGRLAPLTVEEASGEAARQLAEANAEVKRLQAKLQQVTDAYTQVMRGRSSDTENLLSMQDAMNDKERLAAELARRCQGQDPSLAATVQELRAEVAEAKRELASRLHQSTQYQQVKHLLAQRNEQLKMMRERLAAYDPSFARYGDDINAEDD
The following text describes a protein:
Function:
Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
Subcellular Localization:
Nucleus.
Sequence:
MRRPKSSHVRMEPVAPRSHNTMPMLDQFRSNHPETSKIEGVSSLDTALKVFWNNQREQLGNFAGQTHLPLSRVRKILKSDPEVKKISCDVPALFSKACEYFILEVTLRAWMHTQSCTRETIRRCDIFQAVKNSGTYDFLIDRVPFGPHCVTHQGVQPPAEMILPDMNVPIDMDQIEEENMMEERSVGFDLNCDLQ
The following text describes a protein:
Function:
In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.
Sequence:
MDEDFSAQMKKMALAMGTNLSDKDIDLLPPDVRHHGSFNYGKFLEYMQRFQASGQQEEAIRRAFQLLDKDKSGFIEWNEIRYLLSTIPSGGPVAPLTDEEAEAVIQAADADGDGRIDFQEFSEMIRKEKLPKKK
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MKGFFENLFRQNVRSVINTGKKVGARAAAREIINQEWGYPLANHEVLFLTNVYQPKHMKRHPFHIVRGTVAPLAVTLPLGFFVLNYFGVISSKLGLLIALSSFIGGLVIWTISIIFDSLYDQQHTYEVKRGLVMGMMMFIISEVMFFFSFFWSYFYISLSPNIAIGCVWPPYGLTVYSYMGLPLLNTVLLLLSGAILTDGYTILTEQKAVHEKNEKVLAVEEAFKNLMNLYKTKNSINTLTFVDERRDKFFGKESRQEDKIAEQKLIAISAGVKELRDLDWDLYFFENPENIEPNYKEPTNLSVIEYALITIYLKKRNKVIKTRLYFTLLCAVVFLACQGYEYFFAPFSMNDGIYGSLFFLLTGFHGFHVLVGSILIGIITIRFIVGNFNLLNVGTNFQIYKNKSTGFACTLFYWHFVDIVWIFLYIVIYWWGSR
The following text describes a protein:
Function:
Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6-hydroxynicotinate (6HNA).
Sequence:
MQTTISLQVNGQPVEVSAMPDTPLLLILRNDLCLNGPKYGCGLGECGACTVIIDGVAARSCVIPLAGAAGRNITTLEGLGSKAAPHPVQQAFIDEQAAQCGYCMNGMIMTAKALLDRIPEPSDEQIRNELSANLCRCGTHVEILRAVRRAAETRRKP
The following text describes a protein:
Function:
May play a role in flagellar formation and mobility.
Subcellular Localization:
Cell projection, cilium, flagellum membrane; Single-pass membrane protein. Cytoplasm.
Sequence:
MSSSRGSLRALLLAAAAAAAAAAGAVSNKLGYWFSCRRFGLDCPEQLEWRHWNPGTEYVKQLVLKNVSTSVLKIRFKQPTSKAFGMDFPEPFKLRPGMSQPLKVVFRPLKQQHYSDNVELFVGNVSCLVPVHAYTPVTHIEVPPALDFGFTPTKETVTAQLPVRNTGDVRVDVLWKLDAPFSISPLFASLAPGEVVAFTASFTPPEACSYTASAACQLESGAAAICKISGIGKFPYLSVEQAGVDFGAVVVGQRVERLVRFGNHSVVPAHFAVTHDEAGPDDGVFTVGPARGTLGPEEYSMLKLSYTPRATGTFSSETFHIGTAGGNRVALNLRGTAVAPLVTLSTRAFNFGNVAAGATASRVLYIRNHSAVPVPYDFQVDPLDVFAISRTRGVLAPDSTAHVTITFRPMAGLAANLWRRVTLLLKDAEPQGVDLVATAYTDKSRPPPLSQRHVERYMARVLSGGPAVEESQLDSKPPSAATGDPAAALTVDSDALDFGSCSRLSASEYRSVTVTNHTPAKLTAFVLVPEWADPGAAPGDAPQRVFQVFPESADMRPYGQATFKVAFRPPRDAAFFSQQLALVAHTKSQRNFRLVAEHQVLPAWCVPLRATGNTFLHSNPEFGPKVELSSRAVAFPPCRPGERVHQTLLIANSGDTPVAFSFGAAGAALGPLFSAKPAAGVVPPQGHVLVALRFAPTDTRPAAANALVTFNGVASNAVSVSLRGAAHTPRLTTDLPSSTLYFRPTCVGASSQRAVTLHNPSRVPVAFRWRLPARLQGLVTVSPAAGALRGNESVQLQWSFTPAAQKLYEARAACLVMSPPEAANGNAAGATASAASLFPGAGLATGIEWYEGAGATAALAGMGEEEAADAVLLSLVGEGTQGAVALEPPSLELGDLRVGHPVRRPLLLQNCSDGVLRYSLEVGPAEDDQPPAGDATLVDFTAGLDSAAEGGVGGGAGGAGGAALECWVDEPEGALPARASKTVMVTLFPRYRKRYSLQVRCRSSTVAPLLTGPNRPPSGGAGPRPLDAGSEAAAAAAAAAAAAAAPLPPPVIAPLTASTTFPTLEVTDVYCEGLPKQLLWQLLGLNDLNHHLRTEVTATELRLRAAQDRGALTTEAASAAMRPFLMEFGTHGLGGRPRVVHVEISNPTPLPASWQLHSFDDPDGVELENWVEPGRPRTEGERMRDLIAEYKLFEMRPRSGELEPGARCTVTIEFRPSVEGSFELPVFLHITDGKRLRLQLQAVTTPEPLQLLALPPPLRTFRLEPVALGERAPPLQMYVLRNGGPAPLHWRLDTAPLAALAEASWGHPVLELVGPEEGDIEEGGVAAINWRFSPLEAKEYRVEVPVLLGDGGIEVIELLGRGFAPPPAPPHGAAAVQLIGPGAATSPAAPTTAAEDDDTPAAALDSVGGDAEAEAARAAAAADRDWITWRGLSSAPSAGMAGRLALVDHDLVSLGVTPVRGLTRRIIVLTNKSRYPLAFDWDLGCLAPPPPPGLAATQRAAAASAMMGLGGGSLLPASQLQLLAGRPLQGALAISPAAGSLEPGERLVCRVSLHAGVTPQVFEGEVRCHVRIDDDAVAEAEAAAAAAAAAGAAAVAAELPFVEQVEEVIAEAPVRGPPAPPPAVAAAQRASRLRSRLPVHQYMTTAVRTRIEPLNAAFTATMEARTRRLADATRPPSWPEPQSISVTLRGRILDERQLGALRYVPPHERAAARAAVVAGAAWVPPAMVPFWEEEGRSTPAVSAQPSSQGGGGYGVGGYGGGYGSGGSQGGEASVAPSGGDPGGYSPRGGMADSWPSLEPGLGMEETVVGPPTVGLDLSLSLQHAGGAGGAPGGDGDSDSRPGTPSMTAAAHHHHHHPRHAGPAPGSGTAEVMEVTFSGDQQPTGGPMPSPPSISGAPDPDSATPDDDFATSDAAVNAAAAVRAAGGGMGSPQPVDPGGSAAAAASELAPPALPPAPPRGGDIEYDALVSAREVLAGLFAELMEDADVVRAVAFLPEHEVPSFAEVRATPPPCYDPAVRAAAEAARAEAEARAAAEAATKAAAEAEAGAAFAIPAAAAQAATEPPALEDELAADTELARVLVAPEWRAFADFVLESAVLGLMQESAAGDWEMPEEEVGR
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKKYIFMRVLRSLVSIFLVTTLTYTIIYTLVPRKLIFKQDPNYNKIATTADKRDNYENTVFERMGYIEYYDTKELQEKASSMDSSVTVEANATNKAIYEKYINQLGHGWTLGEFTESGQFYATREIPIFERVFHFYANLIDIDHTNKIQDPENPDLKRYLRFENDPAIGWSLVGSGTKHKYLLYFNSQFPFVHQNFVNLNLGDSYPTYANTPVLQVITQGQGQTKTAQVQFPTGKKTSSVNIYSRTYKSPSQADSREVASYGKDDPYTATESNYQYPSMIVSSAITGLIGLVLAYALAVPLGSAMARFKNTWIDSLSTGALTFLLALPTIALVYIVRLIGSSIALPDSFPILGAGDWRSYVLPAVILGLLGAPGTAIWIRRYMIDLQSQDFVRFARAKGLSEKEISNKHIFKNAMVPLVSGIPAAIIGVIGGATLTETVFAFPGMGKMLIDSVKASNNSMVVGLVFIFTCISIFSRLLGDIWMTIIDPRIKLTEKGGK
The following text describes a protein:
Function:
Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro potentiates alpha-3:beta-4-containing nAChRs maximum response by increasing peak current and slowing down receptor desensitization; the activity is dependent on its cell surface localization.
Miscellaneous:
MISCELLANEOUS: LY6G6E is a pseudogene in humans.
Subcellular Localization:
Cell surface. Cell membrane. Cell projection.
Sequence:
MGPSSAFLGVLFLSGTLGLTTSPARGRLRCYTCSFAKPCDPVPRECREDEVCGVSVGTSGRTLVRWPFSRWLLSFLPMAAAATSAFLFCPTEQKEEEVIERKGCLPRAQCPLLGHATYWSRSYSLRHQCCEQDLCNAAASQPPPNLPLMTLLPLAAMIGWGVHDFL
The following text describes a protein:
Function:
May act as a GTPase-activating protein for Rab family protein(s).
Sequence:
MAVSKFSDVDEYGFKREADFDYQSYENIMSSYLSVLTTRSMRWQKFLQSADMLKNRSKLKRFVRKGVPGSLREEVWMKTSGAKDLQQKEPNLYQTLLTYEFDQEISDQIKLDLPRTFPDNIHFEQYQVSLYNVLIAFAHHNRTVGYCQGLNYIAGLLLLVTKNEVSSFWLLKVVVENIVPLYHTKTMDNLITDIDVLSELIRLRAPDVHRHIFDLGLPWPVIATKWFICLYAEVVPTETVLRIWDCLFLEGNKILLRVGLTIVVRLRQDLLATDDISTLIGLFRSLEKSYVLMDCHEFMKSIFKVPGNLRRSQLDALRQRFYTERMANKSKGS
The following text describes a protein:
Function:
Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPGSLKEETALLLEDYFQHRAGGAALPPSATAAELRRAAAELERRERPFFRSCAPLARAEPREAAALLRKVAAQLEAEGGLNWGRLLALVVFTGTLAAALAESGCEEGPSRLAAALAAYLAEEQGEWLEEHGGWDGFCRFFGRHGSQPADQNSTLSNAIMAAAGFGIAGLAFLLVVR
The following text describes a protein:
Function:
May act as an adapter protein.
Sequence:
MAAGKFASYHRNVQMNHPLVSSMDLLGSKSALGERRSDAFKNVCIHGTLPRKKKERVPIRSSDMFCHMGTLPHTKSHRLPNPLMQDIKEDYPFQERRTGIFNMREHYLDPAMEYVKFSKDRYIMDGGTPDKLKKELEEELKLNSEDLRSHAWYHGRIPRQVSESLVKRDGDFLIRDSLSSPGNLVLTCQWKNLSQHFKINKVVIRLNEAYCRIQYQLEHESFDSIPALVRFYVGNRKAVSQQSGAIIFQPINRTVPLRCIEEKYGTSPVRRLELGIMEVKSEPTKRLSLNFGQGISQEQSLVRGNLLRNKEKSGSQPACLDNMREKRRPLKAHQSESYLPLGSRQPCLSQGMDMKTSPKPHVFRTGSEPTLSPTEIRRFNHEVHPVEALRGSDSQLCPRPPPKPTKAPSIKQSQSPLVWQSSEANYCEFHPTPPEDCAWSDSHSSHNSYIEDQRTDEIETLSFSNSELSFPALDDSISQCSATDFCGNVEDDEFIRPVYETVSSFCPNDFQSVLLTAENKPLETSLLRRAKELFTNNDPRTIAKHILRMDCKVARILDVTPEVERMMGVSSGLELIILPYGHQLRLDLMERHSTMAIGIAVDILGCTGNLEERVATLHKIIQLAVEVKTLGDYFAFSAIMKALDMPQITRLEQTWTMLRHQYTQTAITYEKQLKPFSKYLHEGEALDAQEDVTVPLVMPLVTLLERQSVLFEGMDFWENNDRGCEILFNHLQTARQVAHNATVYKKNAQRILEGFKPDELMSEIFKTEFQMRLLWGSKGALLKQSERYHKFGQILTALSRKLEPPS
The following text describes a protein:
Function:
A variant beta-allophycocyanin (AP) which forms a complex with ApcE, a phycobilisome terminal emitter that influences energy transfer to photosystem II.
Subcellular Localization:
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MRDAVTTLIKNYDLTGRYLDRNAMDELKAYFESGSARIAAAAMINANSATIVKRAAAQLFEEIPELIRPSGNAYTTRRFSACLRDMDYYLRYASYALIAADNNVLDERVLQGLRETYNSLGVPIGPTVRGIQIMKEMIEAMAEDSSLNSTDFIASPFDHMTRELSELSV
The following text describes a protein:
Function:
Probable RNA-binding protein that negatively regulates the translation of targets. Functions with RNA-binding protein szy-20 to ensure embryonic cell division, and to this end, plays a role in the regulation of centrosome assembly, position and size, and in astral microtubule outgrowth and nucleation. Required for gonad development, germ cell proliferation and for the production of oocytes. Regulates whole body growth and fat accumulation in response to food availability, and this may be through the mTOR pathway, upstream of daf-15 and rheb-1.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Co-localizes with szy-20 and pab-1 in the cytoplasm.
Domain:
The C-terminal part is necessary for interaction with szy-20.
Sequence:
MSTPTGLPALNGDVLSAINDMIGRVIIINTTDKKRYSGVLGAVSQDFDFGMQCVVEITKENENNLLRTESECRDKMVFHYSDIVDFAYVTQEIKKQHAVSKFVTDRQYHGDTPIEGEELQEWNGGEEDGLGGSIEDDVVVAGGQTAARRSNNHNNGTGWSVNDMFAANEKMNVVSTFKEDLTQYTTVEVVGTDEDRARAERLAREIESNSSSKFMANLENDDDERDLDKITRQEDFENGNGRKRNNNSFNQQQQQRRNPNIAPNGQPVNRRAEGLRGDRRNSGSSSANNSRYGAPAAAQQNYSQNQQQQQGQKGYRRQNEENDWQMAKGKGQNQGHDHSFRQQQKQMLDPRPNNNVKPADDKAQSATTATAAAGGSRVTDLKNWGNEFSIATAPKDQAPAVPAGNSGSAWNRGPPSSLVAKGSSNESTPPPTTNGEEAETKKEEAPSTSVDVAAAPVQNVQNDAEKHQEDDNVSVTSENDSVITSKSSSFKFNINAPEFKPRVAPATPTATTPVQNEYHPQQQPHPAMMAPQQGPPAPGMGMVPPHMGGPQNQGQPPMMMWQQTGQQQQGGGGYPQNHQFPIQHVPMQGVPGQMYGPGAATPVTVAQQPNQQHQVPTSAAGGQNHQLRDGEYREKQPLYMPYGPPQMVPVTSQQFYHSQYQGQMQQAAPYQMKMMPQQAPQGAYQQRYQQPQVYMMPPQGQQQQPRYQGPPPPQQQQQQQPQQQQFSGEQSRPQSHPNSQPTTPGPRGELPKMSGAPQNGNMQAESSSNASHSGSTSSQSGQRSGSPPGAVPPPPPPQQQHQQQQHPPHHAPPHVGAPPPQMMQQQQQHIQQYMVMQGPHQMHPQIPNYYQQPQQVFYPMIMPQQMPMQQNQHPQQSLMGERSDQGFPTSGYFDYRTMPNYQQQQQQQQQQMHRQNSLPQQFQGNQGVNPSGQQSGPPPPPPPSQQGTPRDQQHSQSPP
The following text describes a protein:
Function:
Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability. Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (By similarity). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (By similarity). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (By similarity). Deubiquitinates SOD2, regulates SOD2 protein stability (By similarity). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (By similarity). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (By similarity). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (By similarity). Binds to pre-rRNAs (By similarity).
Subcellular Localization:
Nucleus, nucleolus. Cytoplasm.
Sequence:
MPIVDKLKEALKPGRKDSAEDGDLGRLLAASAKKVLLQRIEFEPASKSFSYQLESLKSKYVLLSARAEGASRHRSGDELQARKPGTERVSGSGGDGVPAPQKVLFPVERLSLRWERVFRVGAGLHNLGNTCFLNSTIQCLTYTPPLANYLLSKEHARSCHQGGFCMLCLMQNHMVQAFANSGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACLNGYAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDIALEIRQAANIVRALELFVKSDVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQSSGDPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPEGPVSRVGATLPSRPKVVPEHSKKSPGNGVVPSPLMAKRQDSVMMRKLPAPEEVGVPVSRNGSLPGLKLQNGCAPAKTPAGSPSPRLTPTPTHMPTILDEPGKKVKKSAPLQSLTTSPTTSQGSPGTGESRSQRPGSWASRDTIFSTSPKLLARAITNGHRLKGEGSGVDLEKGDSSSSSPEHSASSDPAKAPQTAESRAAHACDSQGTNCPTAGHPKALLNGVDAKMVKLKSPALSSTTTEPTSLMSPPPAKKLALSAKKASTLRRATGNDIGSPSPSAFCDLTSPMKATHPVVASTGPVSKTRTAAPAPRPSTHPHSASLSSSSAKPLGTSEPQSCRPSAWTPLPQVNGHFTSHLHQLPEASEALHSPSKKRKKTPNGDPQRLGIDTLLPQCLRGAPAAARRKRKKRCSEGEGATAPKQEGQFQDQSWSSGSQKEEGTQPQVNGHQVSHILDSYHVSSRKRRKRKRSEGLSQEATPSQDLIQHSCSPVDHSEPEARTELQKKKKKKRRKRKPEPQQDEESKHPGDQRSPRPSVTPVPALSVNGHLPSDCLGLGQAPLVTWNRDQEPDVVQALLQDSSDKAYGKKVLTWDGEPSAISQDAIKDSRLARTQTVVDDWDEEFDRGKEKKIKKFKREKKRNFNAFQKLQSRRNFWSVTHPAKVASLSYRR
The following text describes a protein:
Function:
Phospho-beta-D-glucosidase that seems to be involved in the degradation of glucomannan. Is also capable of hydrolyzing aryl-phospho-beta-D-glucosides, although very weakly, and plays only a minor role, if any, in the degradation of these substrates in vivo.
Sequence:
MAHTEQYRFPKDFWWGSSASATQMEGAADRDGKGQNIWDYWFEKEPHRFFDHVGPADTSQFYDNYKEDIRLMKELGHNSFRMSISWSRLIPNGTGEINDKAADFYNNVIDELIANGIEPFVNLFHFDMPMALQKIGGWVNRETVDAYENYARTCFRLFGGRVKKWFTHNEPIVPVEGGYLYDFHYPNKVDFKEAVQVGFHTMLSSARAIQAYREMKQDGKIGIILNLTPSYPRSSHPADVKAGEIADAFFNRSFLDPSVKGEFPKELVDILKHEGFMPDYNAEDLDIIKKNTVDLLGVNYYQPRRVKAKEHLPNPDAPFLPDRYFDPYVMPGRKMNPHRGWEIYEKGVYDILINLKENYGNIECFISENGMGVEGEERFRDEQGIIQDDYRIEFIKEHLKWIHRAIQEGSNVKGYHLWTFMDNWSWTNAYKNRYGFVSVNLEKDGERTVKKSGKWFKEVAEHSGF
The following text describes a protein:
Function:
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Subcellular Localization:
Cytoplasm. Nucleus, nucleoplasm.
Sequence:
MAAEATALWQPREEGLREICGLLEQHISPNSDQSRIWQQLQHYNQLPDFNNYLVFILAHAEGKSLEVRQAAGLLLKNNLRATFSSLSSSYRQYIKSELLPCLGASDRTIRSTVGTIISVLVQLDRVAGWPELLQVLARCLASNDFNHMEGAMDAIYKICEDVPEELDVDVPGLSERPINIFMPRLLQFFQSPHAILRKLSLGSINQFIVVMPAALFMSMDQYLQGLFHLAKDPSAEVRKLVCSAFVQLIEVRPSFLEPHLRNVIEYLLQANKDPDDEVSLEACEFWSAYCDGTLPPDSLREYLPRLIPVLMLNMAYADDDETLFDAEEDESFPDRDQDLKPRFHSSRFHGSDNMEDDEDTVNTWNLRKCSAAGLDILSNVFGDEILPTLMPLIQQKLSATSDSNWKEREAAVLAIGAIAEGCINGLYPHLPEIIAFLIPLLDDKFPLIRSITCWTLSRFSKFIVQSIGHKDGYEQFDKVLTGLLRRILDTNKRVQEAACSAFATLEEEAADELAPRLEIILHHLLCAYGKYQRRNLRILYDAIGTLADAVGSELNQPKYLDILMPPLITKWQQLSNSDKDLFPLLECFTSISQALGPGFSQFAEPVYQRCIGLIQIQLLAKVDHVTAGVQYDKEFIVCSLDLLSGLAEGLGGGIESLVAKSNLRDLLLQCCMDQIADIRQSAFALLGDLARVCPAHLHPRLADFLSVAAEQLSAAAVKEAVSVANNACWAIGELAVQVHQEIAPVVLAVISCLVPILQNAEGLNKSLLENSAITLGRLAWVCPELMAPHVEHFIQSWCTTLCIIRDDYEKEDAFRGLCAIVRVNPSGVVSSLAYLCKAVASWHEIRSQDLHNEICQVLNGYKQMLGDGAWKQCMSTLDPQAVQRLSRFGV
The following text describes a protein:
Function:
Required for normal septin function and cytokinesis. Its recruitment to the bud neck by CDCd11 and SHS1 ensures efficient localization at the bud neck of MYO1, the type II myosin of the actomyosin contractile ring.
Subcellular Localization:
Cytoplasm. Bud neck. Note=Arrives at the bud site approximately coincident with bud emergence and dissociates from the septin scaffold before cytokinesis.
Sequence:
MGLDQDKIKKRLSQIEIDINQMNQMIDENLQLVEPAEDEAVEDNVKDTGVVDAVKVAETALFSGNDGADSNPGDSAQVEEHKTAQVHIPTENEANKSTDDPSQLSVTQPFIAKEQITHTAIAIGDSYNSFVANSAGNEKAKDSCTENKEDGTVNIDQNRGEADVEIIENNDDEWEDEKSDVEEGRVDKGTEENSEIESFKSPMPQNNTLGGENKLDAELVLDKFSSANKDLDIQPQTIVVGGDNEYNHESSRLADQTPHDDNSENCPNRSGGSTPLDSQTKIFIPKKNSKEDGTNINHFNSDGDGQKKMANFETRRPTNPFRVISVSSNSNSRNGSRKSSLNKYDSPVSSPITSASELGSIAKLEKRHDYLSMKCIKLQKEIDYLNKMNAQGSLSMEDGKRLHRAVVKLQEYLDKKTKEKYEVGVLLSRHLRKQIDRGENGQFWIGTK
The following text describes a protein:
Function:
Required for formation of the 2-thio group of the 5-methoxycarbonylmethyl-2-thiouridine modified base in some tRNAs.
Subcellular Localization:
Mitochondrion.
Domain:
Contains two rhodanese domains with different primary structures but with near identical secondary structure conformations suggesting a common evolutionary origin. Only the C-terminal rhodanese domain contains the catalytic cysteine residue (By similarity).
Sequence:
MFSVGKKISFILPIKGVLQKLKDNAQKTVLLDATWYLPTDTKNGKKEYLESRLPGAQYFDIDEAKDHKNPLPHMLPPADEFASYVGKLGIDRNTNVIIYDRKGFFSSPRVFWTFKVFGHEHVFLFPNAFNAWKTEGLELETGEPRTPKPVVYEGAKLNKDLVASFDDIVKVIESPDAAGVHIVDARAHERFLGNVPESRPGLASGHIPTSINIPFTETTAAGITAPKPEEDLEKVFSSHGLTDKSVPIITSCGSGVTASVLFAALKECGFKDVRVYDESWSGYGKRANEDSSLLATGP
The following text describes a protein:
Function:
Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress; Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
Subcellular Localization:
Cell membrane. Cytoplasm, cytosol.
Sequence:
MWSLPASEGESATAHFFLGAGDEGLGTRGIGMRTEESDNELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVIILGEDVILNEPVENWPSCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLAMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPARPEECNLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEIRYPVMLTAMEKLVARKVCVAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVTHPRFFSLFEKHGGYKTGKLKLKRPEQLQEVLDITRLLLAELEKEPGGEIEEKTGKLEQLKSVLEMYGHFSGINRKVQLTYYPHGVKATNEGQDPQREALAPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDGDSLSSCQHRVKARLHHILQQDAPFGPEDYDQLAPTGSTSLLNSMAVIQNPVKVCDQVFALIENLTHQIRERMQDPKSVDLQLYHSETLELMLQRWSKLERDFRQKSGRYDISKIPDIYDCVKYDVQHNGSLGLQGTAELLRLSKALADVVIPQEYGISREEKLEIAVGFCLPLLRKILLDLQRTHEDESVNKLHPLYSRGVLSPGRHVRTRLYFTSESHVHSLLSVFRYGGLLDETQDAQWQRALAYLSAISELNYMTQIVIMLYEDNTRDPLSEERFHVELHFSPGVKGVEEEGSAPTGCGFRPASSENEEMKTDQGSMENLCPGKASDEPDRALQTSPQPLEGPGLPRRSPLIRNRKAGSMEVMNMQCTGNLDLIPLRGRRRRRSGDLPRPSPAIGLQPRAVSTTHLASCTQVLSETSSSRPGSYRLFSSARPPTEMKQSGLGSQCTGLFSTTVLGGSSSAPNLQDYARSHGKKLPPASLKHRDELLFVPAVKRFSVSFAKHPTNGFEGCSMVPTIYPLETLHNALSLRQVSEFLSRVCQRHTDAQAQASAALFDSMHSNQASDSPFSPPRTLHSPTLQLRQRSEKPPWYSSGPSSTVSSAGPSSPTAVDGNCPFGFSDQPSVSSHMIEEHQGLGMLPRNGEQELPIEGVQEPFEPSQSSQEPPVETSQPCQEVVEEISQPCQEVPDISQPCQDIPEEVSQPCQEVPDIGQPCQENHDSVNQICQEVPQIHQPCQKASQLCQKMSEDACQLCQKNPEKVSQPSLDVPVEVGRLAHGFPVGVRDLVQEIHVEVGRPAQETPEEFSQPCQEFFVEVGRLAQEASAINLLSQDIPEVDKPSQEFPGEDDLQVQEVPEINQQSWVVPEVIDQLPGEDIPQAQYLSSDPNPQSQSLAHDQYSPLPPATCD
The following text describes a protein:
Function:
Probably catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules. Overexpression leads to a strong repression of swimming; swimming returns to normal when residues 359-360 are both mutated to Ala. Overexpression also leads to a 20-fold increase in c-di-GMP levels in vivo. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIFMQLYFIYDRRQFSNCVLSLAFLSCLIYFVITVIIIQQIIEERLTSSVVQNDIAIYYLFRQMSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFGGPIVAHILSSHYESYNLHIAELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNISLLFMSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNELTVQSASAQKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGGEEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNEIYRLADNALYEAKETGRNKVVVRDVVNFCESP
The following text describes a protein:
Function:
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting at the trans-Golgi network and early endosomes (TGN/EE). The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus.
Sequence:
MIQFVLLISRQGKVRLTKWYSPYTQKERSKVIRELSGVILTRGPKLCNFVEWRGQKVVYKRYASLYFCMCTDQDDNELEVLEIIHHFVEILDRYFGSVCELDLIFNFHKAYYVLDEILIAGELQESSKKTVARLIAAQDSLVETAKEQASSISNIIAQATK
The following text describes a protein:
Function:
In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
Subcellular Localization:
Nucleus.
Sequence:
MVNVLKGVLVECDPAMKQFLLYLDETSALGKKFIIQDLDDTHVFILAEVVQILQERVGELMDQNSFPITQK