lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:18395520, it may play a role in cell death.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to an intron retention.
Subcellular Localization:
Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=May cycle on and off membranes.
Sequence:
MAQRAVWLISHEPGTPLCGTVRFSRRYPTVEKRARVFNGASYVPVPEDGPFLKALLFELRLLDDDKDFVESRDSCSRINKTSIYGLLIGGEELWPVVAFLKNDMIYACVPLVEQTLSPRPPLISVSGVSQGFEFLFGIQDFLYSGQKNDSELNTKLSQLPDLLLQACPFGTLLDANLQNSLDNTNFASVTQPQKQPAWKTGTYKGKPQVSISITEKVKSMQYDKQGIADTWQVVGTVTCKCDLEGIMPNVTISLSLPTNGSPLQDILVHPCVTSLDSAILTSSSIDAMDDSAFSGPYKFPFTPPLESFNLCFYTSQVPVPPILGFYQMKEEEVQLRITINLKLHESVKNNFEFCEAHIPFYNRGPITHLEYKTSFGQLEVFREKSLLIWIIGQKFPKSMEISLSGTVTFGAKSHEKQPFDPICTGETAYLKLHFRILDYTLTGCYADQHSVQVFASGKPKISAHRKLISSDYYIWNSKAPAPVTYGSLLL
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Subcellular Localization:
Cytoplasm.
Sequence:
MPSLKISPSEAEKIQNYLVSSGFRKINAPYTLWALEGNGVKVYYYKTGSLLIQGKNSEKVLKEVLNLLEKKKLPGCDESGKGDIFGSLVLCCVCIPEENYLKVSSLNPRDTKRLSDKRVERLYLALKPLVKAYCYEIKPEEYNKLYRKFRNLNKMMTHFYKLLIERVKEECGVSEVVVDKYQPSNPFGEDVIFETEAERNLAVAVASIFARYKFLQSLKEVERELGIKIPKGTSKEVKELAKSLKNPERFIKLNFNV
The following text describes a protein:
Function:
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Plays an important role in double-strand breaks (DSBs) repair following DNA damage. Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A. Modulates alternative splicing by phosphorylating the splice factor SRSF6. Phosphorylates SEPTIN4, SEPTIN5 and SF3B1.
Subcellular Localization:
Nucleus speckle.
Sequence:
MVITSSSEEVPPQRMLSALHTEWINKDPVCYLPPSHCNKKPLRSGSSTGCKSSSSSSSSFCLAAPFAFVPTEANMSSQHSHAPFSSLQSMADHQQVLPDMTILQRRIPLTFRDSAAAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQVPPEDSSTKKERKVFNDGFDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDHHDQEWVAIKIIKNKKAFLNQAQIELRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGTPPNHMLDQAPKARKYFDKLPEGTWTVKKNKDLKKDYKVPGTRRLHEVLGVETGGPGGRRAGEQGHSPSDYLKFKDLILRMLDYDPKTRITPFYALQHNFFKKTTDEGTNTSNSNSTSPAMDHSHSTSTTSSVSSSGGSSGSSNDNRNYRYSNRYYNSAVAHTDYEMQSPQAHSQQQIRLWAGGDVPITNSDSYPQILPHKPTPSQPQHFHGNEPHHPHPLYHHVNRPHYHRQLITSSSPQIPESMELSLGHRHPQSSSSLHPHHPSLDCTPFGSSNLHLGVSAFRTRTVSGHNDSGVPLNYPYSSNTSSMVGPPHIRNRTETEESAMLGVCVPQSTAASS
The following text describes a protein:
Function:
Oxidosqualene cyclase that generates taraxerol, a triterpenoid product. Taraxerol is probably required to coat the leaf exterior as a defense compound against pathogens or herbivores.
Sequence:
MSFVWVEESKECSEQRKGSMWKLKIAQGGKDPYLYSTNNYVGRQTWEFDPEAGTPEERAEVEAARLNFYNNRYRVKPSADLLYRMQFLKEKNFKQTIPPVKVEDGEEITYETATTALKRAVHFYSALQASDGHWPAENSGPLFFLPPLVMCLYITGHLNTVFPAEHQREILRYIYYHQNEDGGWGLHIEGHSTMFCTALSYICMRILGEGPDGGLDNAVARGRKWILDHGTVTAMPSWGKTWLSIMGLFDWSGSNPMPPEFWLLPSFLPMYPAKMWCYCRMVYMPMSYLYGKRFVGPITPLILQLREELYDQPYEQVNWKQVRHECAKEDIYYPHPKIQDLLWDTLYIAIEPLLTRWPFNKLVRERALQRTMKHIHYEDENSRYITIGCVEKVLCMLACWVEDPNGDYFKKHLARVPDYIWVAEDGMKMQSFGSQQWDTGFAIQALLASNMSDEIGETLAKGHDFVKKSQVKDNPSGDFKSMHRHISKGSWTFSDQDHGWQVSDCTAEGLKCCLLFSLMPPELVGEKMEPERLYDSVNILLSLQSKNGGLAAWEPAGAPEWLELLNPTEFFADIVIEHEYVECTASAIQALVLFKKLYPGHRKKDIETFIKGAAQYIEDRQMPDGSWYGSWGVCFTYGTWFALGGLAAAGKNYDNCAAIRKGTEFLLNTQCENGGWGESYRSCPEKRYVPLEENKSNLVHTAWALMGLIHSRQAERDITPLHRAAKLLINSQLENGDFPQQEITGVFMKNCMQHYAAYRNIYPLWGIAEYRKQIPLPLR
The following text describes a protein:
Function:
May be an activator of G protein signaling.
Subcellular Localization:
Secreted.
Sequence:
MGLKVTWDPPKDASSRPVEYYNIAYGKSLKSLKSIKVNAETHSFLIKDVEKEVPNKPLRMRVRASDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERSHEIKKLASESVYVVSLQSTNSQGQSQPVYRAALTKRKHAEEDELDVPEDISVRVMSSQSVLVAWVDPLVEKQKRVVASRQYTVRYREKGESARWDYKQVSNRRVLVDSLIPDTVYEFAVRISQGERDGKWSASIFQRTPESAPTTAPENLRVWPVSGKPTVVTVSWDALPESEGKVKEYILSYAPALKPFGAKSLTFSGHTTSALVDGLQPGERYLFKIRATNRRGPGPHSKAFIVAIPTTSSTEASAQPNGRDSSRKPEKLQQPSSPAPKVAASSEHTPSAKNVKDALSDLNKIRTNSVVPGKTQLHSKMGELDPQSTEVTGEEELDSLEDPRSSRLETLNQKQPLRVPSRSGHGVLTPGRTPARTGLPVLPRKEVMDRRGPSLDPHLRPRVEPSASSAYHQLSSIDNDSVDQNEYDQAGSPDPKAVSSPSSPKNPARSRLTSVPSRHAASNMLRDKSRMQPGTKASSSSASSQSHSSTSEEDSSAAAQPRSHSLLQGGSSRPALSRDRQDVHASSSRMPSQTVSSSRPSALTEGSEEEDTSDGGADIDRAAGDTRRRAEATAQIQQTRPALGHFSLIRNKPFPAHSRNPSRFPKLRGPRLQPSRSPQSTSASKVLTRAPSLPASHTRPGSDVYGDGEDEEPLPATVVNDRTPSSSSHPISGGSDTLRRGSQRGASLYRKEPIPENSKAAGADVHPGGKSPLSSKAQGFQLSTDEGAPQTPPSSTSRQLSPARHPASRSQPSPGSTVPRRMAPGRSSELSSSQSKDRSLSQPKLSLAHTGPDRPHAANSRGVLPSAPQNQNEGSQSSYEDNSTEIEGPDPRAPTHSAHAKDTTPSILKPQQMGSQSGNSGNRPQPSRSGASERPIRPGSTHPRVQVPGRAGLQATPAKKISSSKHPLPPESQQSVFTEEEEENEGILKGKEDSLSTSVKKWPSSSSPRNNKYADRNLDRDKAAIGQLVQEEDSIPGRRSPGSPPIASHPPTWYQPRNPVTASPSASTHSWPRYTTRAPSTYSSTTPMLSLRQRMQRRFRTPVSRQPPPRPVLTSGYNGRANVGENIPPGSIGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRVRLGGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPVASAQDKPILSLGGKPLVGLEVIKTTTYSPTTTMLPTTTTTTVLTTTTRPPTTTTTTTRRTTTRRTTTTRHPTTTIRATRRTTTTTTTPEPTTPSPTCPPGTLEHQDEAGNLIMGSNGIPECYPEEDDFSGLETDTAPPTEEDYVVYDDDYGFETTRPPTSTMPSTTAATPKVIPEQGTVSSFPEEEFDLAGKRRFVAPYVTYLSKDPTAPCSLTDALDHFQVESLDELIPNDLTKSDLPPQHAPRNITVVAMEGCHSFVIVDWNKAIPGDVVTGYLVYSASYEDFIRNKWSTQTSSVTHLPIENLKPNTRYYFKVQAKNPHGYGPVSPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPGYTDCHGRQYVKRTWYKKFVGVVLCNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPNIQGYYRQYRQEPVSFGHIGFGTPYYYVGWYECGVSIPGKW
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MKHQQNLDLRLSIGGPFTSLPEKLNGSDQESGVTDVNNRVDIRRRHGKRKREEDPNNNPPFKNRKGNLTNNVDLNKPDPPLPISYPYSSFQYLPFFNAYGYAYPCLVPYWPPGESPVRCRSVSDDGVSNKKSGSSGSSPVCSSSVVSDNHHHSSSSLEGGCSNSSNSSISMKHVKPKPCNKKFVEDQSSQVKKSFSSSMENGKPPKPQIQTQNNMASFEQMPCVSTTGIGPNGTKIITTGFLYRYSNLEVSILCVCHGQSFSPAEFVKHGGGGEVSHPLKHITVLPPTGIFPSSIR
The following text describes a protein:
Function:
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLPKRLVQPVFVARSVYVREELPAELETVTNTTLTNIVRQLSSLSKHAEDLFGELARDAGGLAERANSLQARIDRLAIKVTQLDSTVEEVSLQDIQMKKAFKSATMFDQQIFSRATMPSAMLEVYKTCDKPPPLDKLNCYRDDGKDGLKFYTDPNYFFELWRQEMLKDTERVMHDRGKKVHKPRTDGGADGGGRQKKRPRAPHNTREKQRQRAIGHGETLMPNNVIYRTPNAIIGSQEEAIYNSAMAAAGGSMIYDSRSSSQMPVQMQQGGGVYQQQPIYDQYGNPSAMYGAGTNQMSQESLYAPGTPSRSKSRPSQPPPAPPSSGSGGGTPNASNANTPTRSRSLSTGRDNLPPPPPIPEGLQSPPHGMSNGGTSVAAKLLLNRSGSRAGSPQLGMTGGPQQQQQHQQQQQQQQPQHHHQQQVVVQSMMDQNQIALAQLNQQINNLNNLNMQLNQMSMNDLPPPPPIPEQLSPKQSPPNVAPPPPPPPPPMLDGPLSPSKAPVANGDLYNMPKMHQLKKIPPQEKITYDDPRSDLMKAIRDGIKLRKVEKQNHEAKENDRNKGLHDVASILARRVAIELSESESSESDDDSEGWQETNETSA
The following text describes a protein:
Function:
Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is also composed of SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer with SPTLC2 or SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. Required for adipocyte cell viability and metabolic homeostasis.
Sequence:
MPESECVQCPRESPERETLQGSLGQLPPSIQPFPADWPLLRFLISLYRAPAYHLILEGILILWIIRLLFSKTYKLQERSDLTAKEKEELIEEWQPEPLVPPVSKDHPALNYNIVSGPPGHRIVVNGKECVNFASFNFLGLLDNARIKEAALASLRKYGVGTCGPRGFYGTFDVHLELEERLAKFMKTEEAIIYSYGFATMASAIPAYSKRAAFLCQKGNPRKARVTRRFIVVEGLYMNTGSVCPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGINIDDIDLISANMENSLASIGGFCCGRTFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPDIFQVLKMKCRQIHKALQGTQGLRVVGEAFSPAFHLQLEESSGSREKDIQLLQRIVDQCMNRNIALTQARYLEREEKSLPPPSIRIVVTVEQTDEELAQAASTIKEAAQAVLH
The following text describes a protein:
Function:
During the asexual blood stage, involved in the sialic acid-independent (SAID) merozoite invasion of host erythrocytes by binding to host SLC4A1/Band 3 protein on the surface of the host erythrocyte.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Extracellular side. Parasitophorous vacuole lumen. Secreted. Note=Localizes to the merozoite surface at the time of schizont rupture.
Sequence:
MMNMKIVLFSLLLFVIRWNIISCNKNDKNQGVDMNVLNNYENLFKFVKCEYCNEHTYVKGKKAPSDPQCADIKEECKELLKEKQYTDSVTYLMDGFKSANNSANNGKKNNAEEMKNLVNFLQSHKKLIKALKKNIESIQNKKHLIYKNKSYNPLLLSCVKKMNMLKENVDYIQKNQNLFKELMNQKATYSFVNTKKKIISLKSQGHKKETSQNQNENNDNQKYQEVNDEDDVNDEEDTNDDEDTNDEEDTNDDEDTNDDEDTNDEEDTNDEEDHENNNATAYELGIVPVNDVLNVNMKNMITGNNFMDVVKNTLAQSGGLGSNDLINFLNQGKEIGENLLNITKMNLGDKNNLESFPLDELNMLKDNLINYEFILDNLKTSVLNKLKDLLLRLLYKAYVSYKKRKAQEKGLPEPTVTNEEYVEELKKGILDMGIKLLFSKVKSLLKKLKNKIFPKKKEDNQAVDTKSMEEPKVKAQPALRGVEPTEDSNIMNSINNVMDEIDFFEKELIENNNTPNVVPPTQSKKKNKNETVSGMDENFDNHPENYFKEEYYYDENDDMEVKVKKIGVTLKKFEPLKNGNVSETIKLIHLGNKDKKHIEAINNDIQIIKQELQAIYNELMNYTNGNKNIQQIFQQNILENDVLNQETEEEMEKQVEAITKQIEAEVDALAPKNKEEEEKEKEKEEKEKEEKEKEKEEKEKEEKEKEEKEKEEKEEEKKEKEEEQEEEEEEEIVPENLTTEESK
The following text describes a protein:
Function:
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
Sequence:
MNWDTPIDLAAAGSPSALSHQSLRDNIELVEQLLRQVAAQEGGGDLVELLDRLWASHQDRTGEGLALIRELSLEKSVLAIRAFSIYFQLINIVEQHHERKRLRLQASFSADTAQPGSFCWLFDEMKSLGVSTPEIERVLQQLDVRLVFTAHPTEIVRRTIRTKHRRIVHLLDDLDNALSEWQQQQVHTTMLEEIRIWWRTDELHQVRPTVLDEVAHTVHYFEEVLFEAMPRVRSELVRCLDMFHPSLTRSLGTFCRFGSWVGSDRDGNPSVNALVTWKTACHQRSRVLAKYIKSVERLRDLLSLAEGNPPQDLLLALEQDQRDLGEVYERYSVVYLQEPYRLKLSYILERLEHTRERNAWLEVHGPQRLSQPDEPGWLHYYRHAHELLAELHLLRQCLRTTGIGCRPLETLIDQVEVFGFHLAGLDVRQDSTRHEDTLTEVSAKLRLTATPYAELDEQARLEWLVRELQTLRPLIPAELPFSARTEETIQTFRMIRRLQKEFGSEICHTYIISMSKQASDLLEVLLLAEEAGLFDPATGTGTLMVVPLFETVEDLRNAPHVLEQLFSLPLYRCYLTCHQNLQEVMLGYSDSNKDSGFLSSSWEIFLAQQHIQQVARRHGVQLRIFHGRGGTVGRGGGPSYQAILAQPDGTVSGRIKITEQGEVLASKYSLFELAAFNIETVTAAVIQASVLPTSPPGSRNWELRLQELSDVARRTYRQLVYEQEGFIDFFCHVTPIDEISQLQISSRPSRREGRRDLASLRAIPWVFSWTQSRFLLQAWYGLGTALDGFIRCNRERNLAELRSMYRQWPFFRTLISKVEMTLAKVDLQVAANYVQELLPKEHEHTGECIFALIAAELERTRECVLAITEHRQLLEDNPPLQRSIALRNATIAPLGYLQATLLKYLRYENRQPRSYSRNELLRGALLTINGIAAGMRNTG
The following text describes a protein:
Function:
Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.
Subcellular Localization:
Endomembrane system; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MIPFLSLLIEARTFKKVPEKPIPMCPNGGYYHFLSANDKDWKERFIISQLENITGNWSCEETGAPQGVPGEKMFFMELGSAYYGASTQFVKPLILQNQTLVVQYEVRLQNDLECGGAYVKLFSDENYVPEKVSNETKYSIMFGPDKCGGTNKVHFIFRHKNILSGAIEEKHLKDPPQIKSDKISHLYTLIVRKDNSYEILIDGESSKSGSLLTDFDPAVFPKKDIDDPNDTKPADWVDAKQIPDPNATKPEDWDEDEPQFINDTSKFDPPEGWLEDEPKMIKDPNATKPADWDEEVLGEWEAPDVPNPLCVSAPGCGPYEVPVIPNPKYKGKWSPPMIDNPEYKGEWKPKQIPNPYYYEDRHPHNFMPITAVGFDLWEVNRMIGFTNIYIGTDEDAVYKWNRDHFIPKHKKQEKANSADDKTEQKKELGGLYMKAVKGCKQIWKNFVTLYIAYQWPTIGACAIIVVLNIIVFVLCARSSNYTTIYVNIKVREEPNQEKEENKEEKEENKEESDDEKEKKSEIEDKDEKVEKVFYRFPDGEKLRH
The following text describes a protein:
Function:
In adult males, modulates sexual behavior by playing a role in sex discrimination and maintaining normal levels of sexual activity towards both males and females.
Miscellaneous:
MISCELLANEOUS: The name 'quick-to-court' derives from mutant males being quick to initiate courtship of both females and males.
Sequence:
MMTSLQLETSLPAVEEQVQREKDNDSAEDSHTASTTPTRIPHPAVARFRRSASLRLRGNPAELGLRAEHCPAGGGGFSSRAKLTAIPSSLETRSHPVHLRRNRSWCNLGHKTEQEPEVEASTEALCNAAQCLSLDKEALAPKVGNSSMANGKPRNLSLQLNGGSDISSSGTSSSSSNNKESSPRTTRTPRTPQTPQTPQTPASGVAASVAETPHSCIRQGNCVKANQVKLSTLHESKISPRTPPVTPDSPSTYLDDDIDSMYSFATTTSGRSTMSCEHPYVARNGTTFSGRKMKYVVHCSNYAGQVGPDYLTPTQRAQRQIRRLKELLCIARQDLEQKDTELLRLTREVVELRLFKASLSSPEERSASSDAVTVREAELKTSQDVSPIVDMVDEGNAKGSPRHLSRQQQQQANHSLQAMQMSAEMQSSYADSGHFEDLTMSSVHSKDSQTQSEACGTATPDGEADVGCGAGGDSASNLENYELQRQELISMYEHRIEELIRSQDSATSDLKRSHNDKVEALLQKLAECNTRYSDMVPDYEQAKQRIRELEKQLEDLQRKLIEHEEKQNKMYLHMYQQGQEAERISRADQALDLAQRQPESKVSINELLHQLQSTQDELENIRASECRMRECGSNHALLTAKEAISLWVLGARKTIYRRLLEAQKNRTHVDPEVTLQFLKSAIFYFLTDKENSQGHLQAIESILEFTDAEKQKISAANRTPK
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDLITQLQDKLDHLLYVFGTCIGVLQRDAPPSFFNNPQNQQQQQQQQQQQQQQQQQQQQQQNPQTQQQLPPPPPPPPQQQQQQQQQQQQQQQQQQQQQQQQPQPTEEWDAPSKMALQVIETSKVIESYIEKLPGFDKTEDQQYEDLKNLNTQSKQVSNELLSSRRDAIELLKMVKESILYISEESKNEEIDQQPMQQ
The following text describes a protein:
Function:
Probably does not transfer phosphoethanolamine to lipid A.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTVFNKFARTFKSHWLLYLCVIVFGITNLVASSGAHMVQRLLFFVLTILVVKRISSLPLRLLVAAPFVLLTAADMSISLYSWCTFGTTFNDGFAISVLQSDPDEVVKMLGMYIPYLCAFAFLSLLFLAVIIKYDVSLPTKKVTGILLLIVISGSLFSACQFAYKDAKNKKAFSPYILASRFATYTPFFNLNYFALAAKEHQRLLSIANTVPYFQLSVRDTGIDTYVLIVGESVRVDNMSLYGYTRSTTPQVEAQRKQIKLFNQAISGAPYTALSVPLSLTADSVLSHDIHNYPDNIINMANQAGFQTFWLSSQSAFRQNGTAVTSIAMRAMETVYVRGFDELLLPHLSQALQQNTQQKKLIVLHLNGSHEPACSAYPQSSAVFQPQDDQDACYDNSIHYTDSLLGQVFELLKDRRASVMYFADHGLERDPTKKNVYFHGGREASQQAYHVPMFIWYSPVLGDGVDRTTENNIFSTAYNNYLINAWMGVTKPEQPQTLEEVIAHYKGDSRVVDANHDVFDYVMLRKEFTEDKQGNPTPEGQG
The following text describes a protein:
Function:
Aminoacylates tRNA(Gln) with glutamate. Does not aminoacylate tRNA(Glu).
Subcellular Localization:
Cytoplasm.
Sequence:
MLRFAPSPTGDMHIGNLRAAIFNYIVAKQQYKPFLIRIEDTDKERNIEGKDQEILEILKLMGISWDKLVYQSHNIDYHREMAEKLLKENKAFYCYASAEFLEREKEKAKNEKRPFRYSDEWATLEKDKHHAPVVRLKAPNHAVSFNDAIKKEVKFEPDELDSFVLLRQDKSPTYNFACACDDLLYKISLIIRGEDHVSNTPKQILIQQALGSNDPIVYAHLPIILDEVSGKKMSKRDEASSVKWLLNQGFLPVAIANYLITIGNKVPKEVFSLDEAIEWFSLENLSSSPAHFNLKYLKHLNHEHLKLLDDDKLLELTSIKDKNLLGLLRLFIEECGTLLELREKISLFLEPKDIVKTYENEDFKERCLALFNALTSMDFQAYKDFESFKKEAMRLSQLKGKDFFKPLRILLTGNSHGVELPLIFPYIQSHHQEVLRLKA
The following text describes a protein:
Function:
Involved in the first committed step in the biosynthesis of amino-sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate.
Sequence:
MESKSHAHCFRAQRVLHGKQWQQDAVVTVDENGTISAIESYDGQRHADAIPLGPVDLMPGLIDSHVHGSQGCDVMDATHDSLNTMSRYFATLGVTAFVATTVTAPVAKIRAALAQVAKSKHDGVDGAEILGAYLEGPYFTEKNKGAHPTQWFRELAVEELEDWISYSDNQLLKVALAPEKTGALDAIRYLDAHGIHVMLGHSDADYEQVKAALAAGAKGIVHCYNGMRGLHHRDPGVVGAGLLHPHCFVEMIADGHHVHPAAIDVAHRCCGSRMTLITDAMRATGMPDGQYTLGEYQVDMKQGVVMTSSGGLAGSTLTLLRGVKNIHRWLNVPIEQAWLMASYTPAESLGIQHQLGSLEVGKYASMVAVSSDFSIEKTWVKGRLVFDAATSPRQEALCI
The following text describes a protein:
Function:
Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.
Subcellular Localization:
Cytoplasm.
Sequence:
MLSVLRDNIFSLFMQHLPGVSFIKDLAGHYLYANDQWKRLVSSDTAEDRPGGPDGGQFEENDQRVITEAAGIQTVETVQAEDGVHHWIMSEFPIRDEQGEVVLLGGIGLDITRRLRLEEELNIYRERLASLAVELAVAEDRERSRIAGELHDQVGQNLFLAGLKLGSLKISSLGDDDRRVVEEIRHLIGGALQDIRSLTCQLRPPLLAHGGLVAALCWLGEQFREDFGLQVDIFDDQHEKPLSPEVSSTLFQVVRELLLNTAKHASAPRAAISVTTEADSIMVSVEDGGVGFDVSSVSLNCGKSGGFGLFNARQKIEYLGGTLTVQSEPGCGTRTVIRVPLKGEQHGTTHAESGAQ
The following text describes a protein:
Function:
Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4-amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP). Is also able to catalyze the hydrolytic cleavage of thiamine; however, this thiaminase activity may not be physiologically relevant. Therefore, is probably involved in the regeneration of the thiamine pyrimidine from thiamine degraded products present in the environment, rather than in thiamine degradation.
Sequence:
MEFSQKLYQAAKPIINDIYEDDFIQKMLSGDIGADALRHYLKADAAYLKEFTNLYALLIPKMNSMNDVKFLVEQIEFMVEGEVLAHDILAQIVGESYEEIIKTKVWPPSGDHYIKHMYFQAHSRENAIYTIAAMAPCPYIYAELAKRSQSDHKLNREKDTAKWFDFYSTEMDDIINVFEAIMNKLAESMSDKELEQVKQVFLESCIHERRFFNMAMTLEQWEFGGKVND
The following text describes a protein:
Function:
The erf2-erf4 complex is a palmitoyltransferase with a major role in driving sexual development. Palmitoylates ras1. Palmitoylates isp3. Palmitoylates rho3.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MSYEKHSDAKASRYAWNQPWNPFEVTLSDPTYPMNLEEKNQIPYRFQSVPDDVPEVPHIESRYKNLPGNNIYLCCGRLQMSSQYKAFLISLFALILPGVLFFIFSAFWLWHHVSPAVPITFAYLYALAVVSMFKCSTADPGILPRNAYSLTYNPAHPWSVIPEDRKVLVGSTRSDSVFVNTVYCHTCHLYRPPRASHCHLCDNCVEYLDHHCIWLNTCIGRRNYRYYFIFLLSVVLSALYLTGLGFYTSIGSFHESTDTNFAAHLRRPWAGVSFFLGIYGALGAILPGILFCYQCYLISVGQNVHEYLRAKSTETEDVHPFHDSIWLNFLVVLCRPKNVSYVRPTRKSYV
The following text describes a protein:
Function:
May play a role in neuronal function.
Sequence:
MLCLEKLVAVLLKTQRTSDAYKKGPWKSQRYTVSGSRVAYKRLNCDDIWARKKSRRIPMVPGGTYSPMPESQPLEDSPKALPVLGEQSNSDNDINEPVFIWGISDKAAQRKSISAGEGSFRLQQEKQQPLVHRPGRGKGRLRLPHRLPFKDRHFTCSKIIGRRFACFAQRLSYRRKQSQCDLLNESTGHLPATCSSAASKSLSWNYCSKMTQQMQNLHLSQSKKHSAPSSPNAAKRLYRNLSEKLKGSHSSFDEAYFRTRTDRLSLRKTSVNFQGNEAMFEAVEQQDLDAVQLLLYQYTPEELDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGARESPHFVSLESRAMHLNTLVQEAQDRVSELSAQVENEGFTLDNTEKEKQLKAWEWRYRLYRRMKTGFEHARAPEVPANACLMVSSSTSLTVSFQEPLSVNAAVVTRYKVEWSMSKDFSPLAGEIIMDNLQTLRCTITGLTTGQQYFVQVSAYNMKGWGPAQTTTPVCASPSNWKDYDDREPRHKGQSEVLESLLQQVRALHQHYSCRESSKLQTTGRKQSVSRSLKHLFHSSNKFVKTLKRGLYIATIFYYKDNMLVTNEDQIPIVEIDDSHTSSITQDFLWFMKLSCMWEDIRWLRQSVPISMSSSTVLQTRQKMLAATAQLQNLLGTHNLGRLYYEPIKDRHGNILIVTIREVEMLYSFFNGKWMQISKLQSQRKSLSTPEEPTALDILLITIQDILSYHKRSHQRLSPGLYLGYLKLCSSVDQIKVLVTQKLPNILCHVKIRENHNISKEEWEWIQKLSGSESMESVDHNADCPMQLFFYELQMAVAALLKQINIPRHQARNFRLYTQEVLEIGHNVSFLLLLPASDDVCTAPGQNNPYTPHSGFLNLPLQMFELVHFCSYREKFISLYCRLSAVVELDSLNTQQSLREAISDSEVAAAKQRHQQVLDFIQQIDEVWREMRWIMDALQYARYKQPVSGLPITKLIDSSSEQNLKKISSTSSHIDCLPSTSPSPEMHRRKAVSESQPCSDEEGCSEVFLPTDSDYDSSDALSPRDLDLVYLSSHDIAQQALSGLSGSAPDVLQVHDMKASMGPGQDPQGPGQGPDTDHSCVEFLHSLTLTGLAPKNHAKMVAGTRPPLGFLGKRKPGKHQHYGGFSRHHRWLRMHSETQSLSLSEGVYTQHLSQACGLAEDPGEAEGPGPVVDGPRGLPLAHAASLPEERRSCLQDPRRPLQRVYVEPYSDTLAGQDPKLWTSLSPTPAGRSSLPSSTSSEMSPDPTSPVSEILSSML
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MVGNTGDESAFSYNEGNGNGPKEWGKLKADWKSCEEGKYQSPINIVEEDVQVLPKLGKLRRDYNPAPAIVKNRGHDILFRSPSVVLHSWVFCLPPLFVFLHLHEFAILRSPAVLRSWVFCLPLSFVFLHLHEFAILHPPFSVRRSFSVRRSFSVRGSSVHVGLKKEEEKSSPNRSVFRLLHVGSFLSSPISVLFTWVRS
The following text describes a protein:
Function:
Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry. Preferentially, mediates calcium-dependent phosphatidylethanolamine externalization. During the liver stage, plays a role in the interaction with, and thus invasion of, host hepatocytes. Dispensable for host erythrocyte invasion and asexual parasite development.
Subcellular Localization:
Membrane. Cell membrane. Note=Localizes to the perinuclear region in the early ring stages and re-localizes to the cytoplasm and vesicular foci in early trophozoite and schizont stages. Localizes to the cell membrane in individual merozoites in late schizonts. In stage III-IV gametocytes, localizes to vesicular foci and to cell periphery. In sporozoites, localizes to the cell membrane.
Sequence:
MEEKNIHMQPNINYSYRNPNMYNMNYHNPIVPPPQQQMQLFVNDWKSILSPMQTCKIKQQFDDREFVADYFMGFKLDFNNKYLILDASTELMKFTACEKSEFCYRNCLPKICIPMNMKILSYGKEISKPDILMEKDCTCTFLCFNRPTIKMYDFSNNNNKELIGTIKTPYRCCSYNFNLFDPSNNKIMYMDDTCCQMSILCPCPWGPFKYSNFFLRDANSKEKIAHLRKEVPFLKFVKRDIDNYTLDFEQVQNPEWKMMLLAFALFLDYMYYDRK
The following text describes a protein:
Function:
Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation. Component of mitochondrial ribonuclease P, which cleaves tRNA molecules in their 5'-ends. Together with hsd17b10/mrpp2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity. The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; trmt10c/mrpp1 acting as the catalytic N(1)-methyltransferase subunit. The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after elac2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme. In addition to tRNA N(1)-methyltransferase activity, trmt10c/mrpp1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA.
Subcellular Localization:
Mitochondrion matrix, mitochondrion nucleoid.
Sequence:
MAFVNTLLRTIRCSAVHTLVQEGRSLSLLKASHQLTQSRKIMLSNHVRKEEAKSEPNETLDLEEWKSILKSDIGNAEMVKTETQEDSSLNEMQELVEMWRLAGRAVPQSITTEQLQVLMELPTKTARKKYLKYLSVREVMKTNRKEKKKELKESKSKIESLDQLETKEDTPEKKNTFLLHVWDKSIDTMQRWKCVQAMKFGQPLVFDMVYEKNMSRYELENTVCQLMESEGWNRRSTDPFHIYFCSLQPYSMYHKELVKRYIGAWDNVFVTATDKSHVEMFPKEQLVYLTADSPNELKHFDHTKIYIIGSLVDRCQQTGLSLANAKRLNLATARLPLDRYLKWDVGAKNLTLDQMIRILLCLKDTGDWKKALSFVPNRKHDGFAEPAASKKRNIKNDGGMEYAASTKRNLQKNSKMYKFGASKSFIKPERTDDTSIRSTRKRWWEEEN