lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MKRSVSEVKTKAPVNEASPSPSPDQTANQLSEKKRRIPITSLPTWYKEPVIFKDVAVYFSQKEWQLLEPAQKDLYKDVMLENYENLISVEYYIFKPKLITRLEQGVDLFAKENDVPGDPQQGEAGVSRSDTSAGKKTGDNSTKAEIRKPDNSKTTSLEKQKAADQGRGSQSLRAEKTSKSDDRPSQNKEKCASTSTTEASKTSIPGNKENESAIPGTSSGQTSAATTTPQSAPSEKPTSGKDVEGKPQTMRSSSTNPKRKPARQGKNHFKCKECGKTFNQTLHLVEHERIHTGEKPHKCDTCGKSFRHLSYFLTHYRIHTGVRPYKCKECGKAFNSSSTLNNHCRIHSGEKPFKCDECGKTFKQSTKLTRHQRIHTGEKPYKCGECNKCFGRSSSLREHKRIHTGEKPYCCQVCGKTFRVNSHLSEHQRLHLKVKPYKCDKCGKHFRNSSYLTEHKQIHVPGARVDCPECGKVFACKVALLKHQKRHEANSRYRCKGCGKTFRCKSSIQRHERLHAGEKPFVCHKCDKGFTDKTTLNNHLKIHSGDRPDPCAQCGRTFKKLATLLIHQKKHIKKKPTDV
The following text describes a protein:
Function:
Involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation.
Sequence:
MAGLFKDIWHAMTSYDRHAGIDSPYRTGRHVPLNRNSGLAGVTTASDSRADINSPYLQGDGRGSTMSFDTAYGGRAISPMPSPANGGPYSPGLVSQRQSVHQDAFDVHSPTGEIPMQNFQNGGPPPPPVASSWEKIDRWAEENYPELFDQLGEGCTVNDLNELEYQLDCTLPQDLRQSLQIHDGQERGGLPTGIIFSSMLLDCEEMVQEWENWKTVNQEFMLDPVLVKRQSQAFAAQASSSKDAPNRNQNWRQELLNKQDSVPPAAIQKAYAHPAWIPLVRDWGGNNLAVDLAPGPKGHWGQIILFGRDYDTKYVVARSWAHFLAMVAEDLSSGRWFVDEDTNELKLREFKATRVEPSYFEILRWRMDQKYGRTANKRKSMAPSMASASGMRSPPTPGSPYQSPTEHNEPRGRSLHRLTGTSPMSSPIRPGYGKPSPLARVAEEAPPTTSLTASNASLEAKAADNLMELNTPRTSGEHSKEDIKVNEDSPAKERTSEDKEKKPETEANGKATESKGKQTTVEDAEDMKDIEI
The following text describes a protein:
Function:
As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
Subcellular Localization:
Nucleus.
Sequence:
MERPTPRVTKDMLPECSGKTVRIVGKANQVEGETAKVDSNGSFDMHLTVDNTLEPNHFYEFVVSVKPDSSVQLLTCVDFGTDIDMEVYQKLVLFSHKYNSLFFE
The following text describes a protein:
Function:
Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. Activation by WNT7A induces expression of beta-catenin target genes. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway; The FZ domain is involved in binding with Wnt ligands.
Sequence:
MGPAAGNLVRAVLALCWLAEHCAGISSIDIERPGDGRCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLKFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCSKLPNKNDPNYLCMEAPNNGSDEPPRGSSMLPPMFRPQRPSTGHDLQQHKDSLSRTSCENPGKFHHVEKSASCAPLCTPGVDVYWSKDDKQFAVIWIAIWSILCFFSSAFTVLTFLIDPQRFKYPERPIIFLSMCYCVYSVGYIIRLFSGAESIACDRDSGQLYVIQEGLESTGCTIVFLVLYYFGMASSLWWVILTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTIMILVMRRVAGDELTGLCYVGSMDVNALTGFVLIPLACYLIIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNMDYWKIVASQQKCKMNNQTKNLDCMMNNSIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQNVCSRRLKKRSRRKPASVITSSGIYKKPQHPQKTHLAKYESTLQPPTCV
The following text describes a protein:
Function:
This protein is one of the chains of the nonenzymatic membrane component (F0) of mitochondrial ATPase.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MLEGAKSMGAGAATIASAGAAIGIGNVLSSSIHSVARNPSLAKQLFGYAILGFALTEAIASFAPMMAFLISFVFQVR
The following text describes a protein:
Function:
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Sequence:
MEFLFGRRKTPEEMLRQNQRALNKAMREMDRERQKLEQQEKKIIADIKKMAKQGQMDAVKIMAKDLVRTRRYVKKFIMMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMATMNRQLKLPQIQKIMMEFEKQSEIMDMKEEMMNDAIDDAMGDEDDEEESDAVVSQVLDELGLTLTDELSNLPSTGGSLSVAGAKKGEPSAALADADADLEERLNNLRRD
The following text describes a protein:
Function:
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.
Sequence:
MDTIKLKEFYNSLVSIRRRVGHRRLGIAVSGGVDSMLLSWFMKESQIMFGWPNQFIAFVVDHRIRKNSTEEALQTIWNLNRMLIPNVYLNINWGNDDVHSLTNLETIAREHRYQVLTRACITHNIRHICTAHHANDQAETIFMRLLRRKPGTWGGLCAMKPVSQIPESDSICGASNIELLRPLLPYYKNQILNTAKQHGIAWEEDPTNADINLTPRNAIRRFLNQHAALTVEATKLATAFQSLQVNIDNKVDEILKDNIVSYHQPSGTLSLCFSKNELKKHSNLTKEELLLRCLTLTTSCRQIKRSSVVSLCNSVFDGKKLTIAKCLLTSSSIKDDTKLQLQISRQPFSKAELKKKTITINPDRYVLWDHRFWIKYSCKNTQTTLILRPLLSKDLNSLKGFLSKEEFLKFCIQVPGHIRFTIPVLSEENDKLVGIPTFGFNFRSDIISNCLHKFKL
The following text describes a protein:
Function:
Cryptic version of the phage P2 OGR protein which acts as an activator of P2 late transcription.
Sequence:
MFHCPLCQHAAHARTSRYITDTTKERYHQCQNVNCSATFITYESVQRYIVKPGEVHVVRPHPLPSGQQIMWM
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTIVVTSEEDPSLSVVRFTSELAWADAGPEVAEPQVARLCMEAQEFIVMGRWLDLASLMLTSADLIFSRVSEKDLECSFAIICNLVTKTESPDEALEMAKLISAKVSQQANDKPALRLKILFTLYNLLENPYSRFYVYMVALTLAVNGKVTEHIIPSFKKIDNFLKEWNIGTLDQRQLFLTISNILKENKSSAKDSFHFLTKYLATFSSEDAYTLSEAKEEAVRAIVEFVKAPDMFQCDLLDMPAIGQLEKDGKYALVYQLLKIFLTQRLDAYLDFHAANSTLLKSYGLVHEDCITKMRLMSLADLGSNDSGEIPYALIKETLRVTDDEIELWIVKAITAKLLDCKMDQMNQVVIVSRCTERVFGLHQWQSLRSKLATWRGNIANVINTIQANKLTEESAQAMQGVMIR
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.
Domain:
The SWIM-type zinc finger is required for ubiquitination activity.
Sequence:
MLRGGCKASEKRRHLSESLSWQQDQALSSSIYLLRQIGPTGFLLKEEEPEKGDFRVLLGNPHECSCPTFLKRGELCKHICWVLLKKFKLPRNHESAFQLGLTEGEINDLLRGIHQVQAPQLRASDETAQVEEDGYLKQKDINAGDICPICQEVLLEKKLPVTFCRFGCGNNVHIKCMRILANYQDTGSDSSVLRCPLCREEFAPLKVILEEFKNSNKLITISEKERLDKHLGIPCNNCNQLPIEGRCYKCTECVEYHLCQECFDSCCHSSHAFASREKRNQRWRSVEKRSEVMKYLNTENEGEAKPGCFQEKQGQFYTPKHVVKSLPLLMITKKSKLLAPGYQCRLCLKSFSFGQYTRLLPCTHKFHRKCIDNWLLHKCNSCPIDRQVIYNPLIWKGIATDGQAHQLASSKDIACLSKQQEPKLFIPGTGLVLKGKRMGVLPSIPQYNSKVLTTLQNPSDNYQNITMDDLCSVKLDNSNSRKLVFGYKISKQFPTYLKNPTTGQTPSQTFLPSLPHKNIICLTGRESPHIYEKDHIGQSQKTSRGYEHINYNTRKSLGSRLRQHKRSSALSSEDLNLTINLGTTKLSLSKRQNNSMGKVRQKLGHPPRRPAYPPLQTQNAALSLIMQGIQL
The following text describes a protein:
Function:
GTPase that plays an essential role in the late steps of ribosome biogenesis.
Sequence:
MVPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGQAKLGEHEFIVIDTGGIDGSEEGVETKMAQQSLAAIDEADVVLFMVDGRAGLTVADEAIAQHLRRIEKPAILVVNKVDGIDADAASAEFWQLGMDQMYQIAAAHGRGVGALIDRVLNPFAEQMESEQAQLEDLTNEEDPEEEQLEYSEEEAEAEYKRLQDLPIKLAIIGRPNVGKSTLTNRILGEERVVVYDMPGTTRDSIYIPMKRDEREYVLIDTAGVRRRKRINETVEKFSVVKTLQAIEDANVVLLVVDARENISDQDLSLLGFALNSGRSIVIAVNKWDGLSFDVKEHVKKELDRRLGFVDFARIHFISALHGTGVGHLFESVQEAYRSATTRVGTSVLTRIMKMATDDHQPPMVRGRRVKLKYAHAGGYNPPIIVIHGNQVNELPDSYKRYLMNYYRKSLEIMGTPIRIQFQNSENPFEGKTNKMTLSQERQRKRLMSMVKNRRK
The following text describes a protein:
Function:
Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTENLQSESIPHEILPKEPFDLPMNNLKSSPKNKDSEKRINNSIAESEQVVDSALSNPETNANEDIIAPQLPSQNSEIIEKNSPVNKLNSSTSLTTHQLASLPKLEVTDHDNVSEAETVVLNEDEEKETSLVGSVSVTEDLGDSSAIGRTILVNNSVEPQMENTANITIVSPSLKESDFESEEKATNDNNGLIETNHNSKLEESSEHEEEEDEESNIERTEDSDHQIPQRGGTLEAPRKGGPRSGVGSRKRKRATVSRKWSTNSESKIKRVALETSQEESDREIADRRSASEQAHEADDEKAIKRKEAFDALLNIETEFTFLRNRLYGKKLLKLNEHEEMIQNETHERFNACIDLITERRDDRVRLATENLMKQLGNIKNVMDYVTKQRKYQLLFDKRRIRQALLTKIATKCFQLLNKQKSVHDPTYITQKTMSYRQSALLQKQRIEYEAAVLCELNSFAGFPTAPIIETASFDDIRNDLLEMGCLSENQD
The following text describes a protein:
Function:
Cell wall biogenesis protein that participates in the organization of the beta-glucan assembly. Involved in the mechanism responsible for cell tolerance to polyhexamethylene biguanide (PHMB), an antifungal agent.
Miscellaneous:
MISCELLANEOUS: Present with 688 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MKACSILFTTLITLAAAQKDSGSLDGQNSEDSSQKESSNSQEITPTTTKEAQESASTVVSTGKSLVQTSNVVSNTYAVAPSTTVVTTDAQGKTTTQYLWWVAESNSAVSTTSTASVQPTGETSSGITNSASSSTTSTSTDGPVTIVTTTNSLGETYTSTVWWLPSSATTDNTASSSKSSSGSSSKPESSTKVVSTIKSTYTTTSGSTVETLTTTYKSTVNGKVASVMSNSTNGAFAGTHIAYGAGAFAVGALLL
The following text describes a protein:
Function:
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
Sequence:
MSRTVMCRKYHEELPGLDRPPYPGAKGEDIYNNVSRKAWDEWQKHQTMLINERRLNMMNAEDRKFLQQEMDKFLSGEDYAKADGYVPPSA
The following text describes a protein:
Function:
Cruciform DNA-binding protein which exerts an enhancing effect on the cleavage of cruciform DNA (X-DNA) by endonuclease VII from bacteriophage T4.
Miscellaneous:
MISCELLANEOUS: Present with 2990 molecules/cell in log phase SD medium.
Sequence:
MSSELMFNYTFSWPAGPKDVILTGTFDDWRGTLPLVKTAKGNFEITMPVKLANKDDTFQFKFIVDGVWCVSDSYKKEHVSEGIENNFLQITDLVETQEVAGASRIPEAGGLLCGKPPRSAGPPSTSNRKKNKRNNKKRRSKLKKKSTKNNKKSNESLDDNEEEDGVTGTTTEDVTGTSREETPLAEPTNVSKEAPGNFHILPIDQSADTTQSNGIIGGPGPVLVPNPGEIKEFTEIRDVDARELNERLNKKEEVPEPVAGPIVESSVTEKSPALPQADDPIVETKEVAHNVQELTPQVEAVTPLINEPEPLPTPEAQISIPESSKVEPVEGSLQSKLVEKRESTEGVLDGSKKVENKAKKDEEVFTLDPIVNKAPKLPLTDEQTAEGRKSPAVSEEKEKKKKQEKGSKEVKRSETSKEKKPSAKEVKKQTVKAPKKQTASPLSSSTEEPKKKKTGFFGKLKKLFK
The following text describes a protein:
Function:
Lignin degradation and detoxification of lignin-derived products.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MPRYPWTDGPEYITQCPIPPGSKFSQKIILSSEEGTLWWHAHSDWTRATVHGAIIVYPNNGAKYPFPKPNAEVPIILGEWWKSDVNAVLNEALVTGVDPNVSDSFLINGQPGDLHPCSNQEVLFFSIAKHKMIVVGIDGSYTKPLTRDYIIISPGQTFDVLLEANQCPDHYYMAARVYSIALVGNYDNTTTTAIVQYRGYYTPSSPPSLPYLPGYNDTNASVHFMGSLRSLWDAEHPCNVPLSMNTKLIYTISMNTFPCANNSCAGPNGTRFAASINNISFQSPRIDILKAYYYNINGVYGDKFPSIPQVVFDFTSEYPPLEYETPRNGTKVRMLEYNSTVEIVFQGTNLVAGTHHPMHLHGYSFYVVGWGLGNFDKNRDPLRYNLVDPPLQNTITVLKNGWTAIRFKASNPASINTFKNSSTHVKEKISRAIRNSKKIEGVVFRTREDQAVIPEKMWLITKMKLLQILVFLLFGGGIHCQASIHRHTFVVKEALYTRLCSTKNILTVNGRFPGPTIYAKKGEIITVDIYNRGKENVTIHWHGVKMPRYPWTDGPEYITQCPIQPGSKFSQKIILSSEEGTLWWHAHSDWTRATVHGAIIVYPKNGTKYPFPKPNVEVPIILGEWWKSDVNAVRDEGLATGADPNISDSFLINGQPGDLHPCSKSGTFKLTVDHGKTYLLRIINAALQEALFFSIAKHKMTVVGTDGSYTKPLTRDYIIISPGQTFDVILEANQRPNHYYMAARVYSVAPLGNYDNTTTTAIVQYKGYYTSSLPPSLPHLPGYNDTNATVHFTGRLRSLGDAEHPCNVPLSMSTKLIYIISMNTFPCADNSCTGPNGTQFSASINNISFQSPTIDILKAYYYNISGVYGDKFPSIPKMVYDFTSEYPPLEYQMSRKGTEVRVLEYNSTVEIVFQGTNLVAGTHHPMHLHGYDFYVVGWGFGNFDKKRDPLRYNLVDPPIQNTIFVPMNGWVAVRFKASNPGVWFMHCHLERHLTWGMDTVFIVKNGKHPEAQMLPPPSDMPPC
The following text describes a protein:
Function:
Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
QVSLRGASAKEDSRDVLLEKIARDRASRVLQRRTLAATLTVQRIWRSRRAARIAVNAIQLLWDERVEEIHRSGIVSAEAFADDILRPFIFFTRNLSWLTRSFFVKDLQRVSICFQALLQSVNFPGVNARNFCKLACGTPSRKTQWFYQVHRLLTICSAILIGRRRSDAVSTSLLALAMRLLVTLTDSKLWNGFEDRQRETGAVTSEIVQWFGAGNSGFYYAAHAYLMEGNTADLETKESFLVTASLITMAFRPFHAIAAELSCQRYARDLEDWKGKAAAQICRHVLTVPCLIERLPAGLVPAFQHENVLAMKTKFFLLKQTFGITVLSEKDSNVPHQAWSLTNVVSIVSVGSLSEPMYSHFVEAVCCLLHSMIPWIEEVRERKRSYEDSGDEDTEDYTELHSRCGGAALDSFIRLLRPLFDQRQVLQLFEKATSSSVGLPNIARLYSYLLTTFSVLNFGGGALPVLNVLAFTKELLPQLWNWFMSSIQLKIVKMPESRGALPAKEQSSRQLSSKLANTFLKRTKSASSESISEVHDDGQWHIEQLKGGPAALSEDAASVLTLFCTLYAHLLLVLDDNEFYDKQVPFSIDEQRLISAALNTMLYHGFFLAGRTQYATLMEASTRCLRALYERDSRRSFCPAALWLAPATEMRPAIAAAARAHEAASVSKAGEASAIGSILTTMPHVLPFEERVQIFREFINSDKTLRKIEGEIVGPGPGSTEISIRRDRIVEDGFQQLGALGARFKGCINVSFVNEHGLTEAGLDYGGLFKEFLTDLAKAAFDPGYGLFQQTATEERFLFPHPAASSLGQGLRTIEFLGRIVGKALYEGILLEHLFSPVFVSKILGRYCPIDDLSSLDGELHRNLMYLKNYEGDVSDMALDFTVTEEYFGKRKVIDLVQGGDKIPVTDANKLQYVHAMADYKLNRQVRPVVNAFVRGLTDLVSPSWLGLFNAKEFNQLLSGEEHDFDVNDLKANTRYTGGYSVTSRTVKLFWEVLEQLDVKERCAVLKFVTSCSRAPLLGFKHLQPPFTIHKVTSDAPVWTFLAGQDVDRLPSASTCYNILKLPAYRRIGTLREKLQYAIRSNSGFELS
The following text describes a protein:
Function:
Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Involved in maintaining genome stability where it acts in the cellular response to DNA damage. Has a role in meiosis.
Subcellular Localization:
Nucleus.
Sequence:
MQFNGSNGIDESSVIDLTRSPSPPVETSISSTNIIDLDAIPDDSFPSSPVLSPRRRRMNRRRNERSRNFPSNHLSYLEDMIYLGPQVSTRRSSSRRDLMGMIARTFPEFSSVNSLSPSLFQLIVNRMRFDAIHPEWTNGSDDEYFSNHFEESYDDFTSSLENIKQSYKPPGPPKSGFTRSFNNDTLMVCPRCQEPLGTSKSKEKSALWATKCGHVYCGSCAKVLKTSKRSQSKCLVNDCGRYLNTKNAMWELFY
The following text describes a protein:
Function:
Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
Sequence:
MGAAGDAAIGRESRELMSAADVGRTISRIAHQIIEKTALDDPVGPDAPRVVLLGIPTRGVTLANRLAGNITEYSGIHVGHGALDITLYRDDLMIKPPRPLASTSIPAGGIDDALVILVDDVLYSGRSVRSALDALRDVGRPRAVQLAVLVDRGHRELPLRADYVGKNVPTSRSESVHVRLREHDGRDGVVISR
The following text describes a protein:
Function:
Plays a role in meiosis, germline development and oocyte morphogenesis. May play a role in DNA replication. In the germline, involved in the maintenance of transition zone nuclei and in chromosome structure and organization, but not required for mitotic proliferation.
Subcellular Localization:
Nucleus.
Sequence:
MASIELRNVQTELAAKNLQFKVLTEKFLEQRKELFDAKKTDSNVEYVECLSEKLRVATERISDLEKETKEGKQVANEEIGRLEKLLREAQQKRDAKIDESYQTFLRIELLVANLGESTDPENEKRIKNLMPAAKTGIPPEGVLRLTINALDSAARESKKKTMAIESLTKQVDDANKLTEVYMKRLEELEDKHRFEEALTLKIQAMMIETTGQLEAQKKIIADLQKKNDDLMKEEEGEEDYEEEENYEVEEDFEDEEEYDEEGEEEDYE
The following text describes a protein:
Function:
Nuclear transport receptor that mediates nuclear import of proteins. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (By similarity). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (By similarity). Mediates the import of pre-assembled proteasomes into the nucleus during the late stages of sperm development.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSLQFQNDCGDSVKQAIIEELQNLLSSDTGVLQQTEKRIKQLEYTEGYGVYLSEIIMNQAHELPLRQIAIVMLTRYVENHWTDDDDVKRKANGCMASEQAKRTIRNILPNGLYDPNSKIRSSVAHTISTIAATDYPHCWAELFDIIVKCLGGNEDSIHGAMQVLQDFSYDVEQIKELGPVVIPEVYRIFDSEQNYSIKTRVSAIRILKPLFASIAALITNKEEQSTMMSSILTNFMDKLMHYLSMNSGAVSSFLLRTEIIKVFTHLVNEMPKYINPFMDRVLPIVWQLLTQIAETYVKVSVNQTETSPLASGDSEEDDEQTNFQSLIIQILEFINCILTCNKLRGSIKNVLADLIYITIVYIQLSEEQLEDWHDDPEKFVDDEDDGGVELTVRMCGRDVLLAINDEFGANAIQPLQEALGRHFSVADAEKAANNPNWWKIQEACMDAVHAFRDVILAGDSTFDLLNYLTIVRNLLVHQESPPLVGRALWTLSIYSKSDLYNPQMLTEILDVTLCSLSPEKSHILRISAVRTLNGFLQANETIDGEKRTLLVSKLPGFLDGIMALVPGSKAAVLALLMEALTFMVKFDAEFAFASQAKITPLAIAVFLKYTEDPYVLETVQDLIKALCQRKECLGPLQEKFIPTIVSILGLTGAASTEKQDIALDVLNTIVRYTEPPLNNSLLETAFPAIINCVLHTDDHAVMVAGGECLRSFINVSPEQICSYKNGEGINCIMQVVATVLLNPMNSEMTAAGQIGRLVITIITKMGSMLGQNVDMLLKAVISKMQNLECLKVIMNLVLIFAHLFLTQMDAVLNFLSTVPGPNGEPAMQFVLTNWLSRQNSFFGNYERKVTTMALCKLFEYGVATQDNRLTTITFKELVDDPTDTRRRTRSVAATTQKWVTIPALVKIFKVLISEYQHFQEGKSDEPLTDSEEDGDDEDAPGNPDKPRYISDLFESDEDNAEDEQLLQELLKETNYQGDIADNLQKFLTTFTQNEHFPTFYEHLTEGERLILLSKVQQK
The following text describes a protein:
Function:
Iron-storage protein.
Sequence:
MQGNQAVVDYMNELLSGELAARDQYFIHSRLYSEWGYTKLFERLNHEMEEETTHAEDFIRRILMLGGTPKMARSELNIGTDVVSCLKADLQTEYEVRDALKKGIKLCEEAQDYVTRDLMVAQLKDTEEDHAHWLEQQLRLIELIGEGNYYQSQL
The following text describes a protein:
Function:
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.
Subcellular Localization:
Cell membrane.
Sequence:
MKTFAGFSFLFLWLQLDCMSRGEDVEQSLFLSVREGDSSVINCTYTDSSSTYLYWYKQEPGAGLQLLTYIFSNMDMKQDQRLTVLLNKKDKHLSLRIADTQTGDSAIYFCAES
The following text describes a protein:
Function:
Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells. Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function. Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1. Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells. Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function. Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation. Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear; May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted.
Sequence:
MGEAHFLIWLLLQLLCAAAVEAPDPRAEVPVVWAQEGAPAQLPCSPTIPLQDLSLLRTGQVTWQHLPDRGPAAPSPQSPGPRRYTVLRVAPGGLRIGRPPLQPRVQLEERGLQRGDFSLWLRPARRDDAGEYRAAVSLRDRDRALVCLLRLRVGQAAVTASPPGSLWTSHWVILNCSFSRPDFPASVHWFRGPGRVPVQESPHQHLVGNFLFLSQISPLDSGTWGCIITYRDGFNVSITYNLTVLGLQPPVPLTVYAAAGATVDLPCHLPRGVGTQSSLTATWTPPGGGPDLLVAGDHGNFTLRLEAVSQAQAGTYTCRVHLQGQQLSATVTLAVITVTPKSSGLPGNPKKLLCEVTPASGQERFVWSSLDKRSWRSSPGPWLVLQEARLLSQPWQCQLYEGERLLGTAGYFTELSRPGAQRSGGALGAQKTGHLPFLILGTLLLLLLVSGAISFHVWRRRWRPRRFSALEHGTHPPQAQSKTGELEPEPELEPEPELEVEPQPEQP
The following text describes a protein:
Function:
Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MAPRKRTGAAGWGACFEEACGLAAVAAGQLIKQSQDDGGGEVVTWKISPVNDRLRMVTSRQMTGMALHPCSNNEKHSSVESTKKWHSSLLGMSRCTASARNLDMCGTGPGGCDGVEDTQSPFRTPPSLSYRCSEQQLNGGVVSDGGPEQLGAGEHKKALLDLLDQVEDAIMEEELPADGENKGEQLINGDPKNISCSPIADSDQNVPSQKSLDAPPFDSFLVLEVSEKHKGDNLPCDRYPVKVLRLLNEHGGKEHAVHLCDEWFHSLISPGDTVSVIGEFTDHGICIIDHDKNLVIVHPELLISGTRVASSFHCPRRSVLDDRLKSNEYSTSALIGTLLHQVFQAGLLEDVPSTQFLEQQAKEVLLKNIESLYACGASESNTLKTLIEAVPKILNWYKCFMKVSKCNNVNFGQIEGQKTVGVVEVMDIEEMAWAPRYGLKGIIDASIRSRVSCNGSSYDRVMPLEFKTGKGTSGQTAVEHTAQVILYTLLMTERYLNKDIDLGLLYYLHTDQTLGIKVKRSDLIGLIMRRNELATEILKASISQSFPPMIQAHGGNAATSGLGDLFDNLVNHLTVAHHTFLKHWDRLIDLEARVSQVKKKEIFQPHHSNTGSRHSSPSYFVLDVTNGHSIDSSGKSKRYIYTFLRQKLQPETADQPGEHVESVDFSLKCGDSVVLSTKSGRIAVANGYIRDLSRAHITVSLPRRLRLPGSNSLLEQGDLQCEVWRIDKDESVSSFATMRLNLVQLFAENPQNSHLRKLIVDLEAPRFDSGGLLSQDPALSYIQSLPNLNNDQQRSLHKILAAKDYALILGMPGTGKTYTMVHAVKSLLMRGESILLTSYTNSAIDNLLMKLKAEGVDFLRIGRHEAVHPDVKGHCLSTTDIQSVDAVKARMEQVQVVGVTCLGIYHPLLAHKKFDTCIMDEAGQITLPVSLGPLMLATKFVLVGDHYQLPPLVQSSEARENGMGVSLFWRLSEAHPQAISALRCQYRMSSGIMELSNSLIYGNRLSCGSLEIANAKLKLSGRGPVRLKLKEILNPDRAVVFANTDEVPAFEAKEHRTVNNPTEALIVSWITNELLKRGVAQDGVGIITPYNAQANLIQQHVDASVEVHTIDKYQGRDKECIIVSFVRSNGNTRASGSSLLGDWHRINVVLTRAKKKLIMVGSAATLSTIPLLRLMIEKVAERGGQLDLTNKDVQSIRELTSSRLNVQ
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKKKKVPVGKHKQGGGKSGRWKQGGPKTQGGHSENVFETLWTRRKFDVLGKKQKGGDAKRVGLARSAAVEKRKKSLLPEYKQRGKTNAFLDSRFGEHDESLGDEDKAILRFQKERMVQMQKKKKFALEDDDDEQPTELLTHGGNALSTFDDFKDDISIESDGDDDGLNEEIVRDLHFGGGFVGKDAGEEDGEGKKRTKKEIMEEVIAKSKFFKAQKAKEKEEDHELKEKLDADFTALAQSSGLLSLVRPKKVDALKSMLSKGASGSGSALKALIAGDQTLEVKEKPDEYDKLVKEMGFEIRGHASDRSKTAEELAKEERERLEDLERKRKQRMLGGAESESDEAESDQDEEESRRQQKKKRREISGDDLGENFVMEDEYQENGWVDEVLARKGDSDEDEDEDEDEDEDEEDDDDGSSARSEEDADSEGSDDEDESEGSEDEDWENSEDELAGIEGIPKLSAKDQNLLDKLIAAKSGPKPEEQVKNLLEKELKIPLRAEKAKKAKKPVSGGNELDSALPYVIDAPQTLVDFRQLVDSRSIKDLEVAVERIRKCNAISLAAENRKKMQVFYNVLLQYFATIAGERPLNLQRVNALVKPLIELSGETHYYAAVCARERIIRMQKQLSEKLHSQDDISSWPSNRTLLLFRLWSMIFPPSDFRHAVMTPAMLLMSEYLLRCPVKSGHDVAVGTFICSLLLSVMRPARRFCPEALSFLQALLLSALPKMNRSKNLSLHCPSHLVEFVASKQWLQLSSATSTVEGVQPLDFTSLLTADSSSSTFESDSFKVGILYSVIKTVSGFVEVYSNIASFPEVFSPFASLLDALKNNNALPEALMVLTTEVSQFIAEKVKEHETTRLPLLMRMSKPVPIKTYNPQFEENYVKGRDYDPDRERAETKKLKKQLKREAKGAARELRKDNWFLAEEKAKENAVLQQEREEKYNKAMSFLQQQESAFKSGQLGKGSSKRKKR