lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (By similarity). Sphingosine-1-phosphate (S1P) probably acts intracellularly as a second messenger perhaps by promoting cell proliferation; the absence of S1P lyase increases its concentration. This leads to increased lateral pseudopod formation as well as defects in the efficiency of chemotaxis. Overexpression of S1P lyase causes decreased growth rates, entry into stationary phase at lower cell density and increased sensitivity to the antitumor agents cisplatin and carboplatin; these effects are more pronounced in cells that express more enzyme.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MDKANDYLKDYQPAKLVLATAGITAASILAYQAITDRDFKDKLNKKIFRSIKSMPGVSDIVKKERAKAKVELKKMFKTDVRNAHYTLPLKGIKHEDLIEEMKALAKVDESHWVDSKVSGCVYLGEKEHTKLLNEAYSLFSLSNPLHPSVFPSIRKFETESISMVSNMLNAHSKVVGSLTSGGTESIFMAVKAYRDFYKDRTDRPEIVVPVTIHAAFDKACEYLKIRIVHIDVDPVSYKVDMAAMKKAINKDTILVAGSAVNFPHGIIDPIDEIAKLAQQYDIGCHVDACLGGFILPFAEKLDYDIPVFDFRIPGVTSMSVDTHKFGYAAKGTSVVLFGNKKLRRAMYFVAPNWPGGIYASPTLPGSRPGGLVAACWASLVSMGNDGFLEKAKGVMETTKKIIKGLQSINGVKIIGDPKAMVVAFTCDNIFYVNDYMSKKGWHLNALQRPNSLHVCVTAKMIGMESLFIEDLKDSIKLVKDNSGSLPKDGTAPIYGSAHSVPDREMVGTILSDFIDELITPDYKPSQST
The following text describes a protein:
Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MLVSGLLLGALFFCLSALVVLSVWRQRKVRGSLPPGPTPLPFIGNYLQLNTKQMYDSIMKIGEKFGPVFTVHLGPRPIVVLSGYEAVKEALVDQAEEFSGRGEQATFDWLFKGFGVAFSNGERARQLRRFSITTLRDFGMGKRGIEERIQEEAGFLVEALRGTKGAPIDPTFFLSRTVSNVISSIVFGDRFEYEDKQFLSLLRMMLGSFQFTATSMGQLYEMFSGVMKHLPGPQQQAFKELQGLEDFITEKVRENQATLDPNHPRNFIDSFLIKMQEEKKNPNTEFFMRNLTMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKIHEEIDRVIGRNRSPKFEDKAKMPYTEAVIHEIQRFGDMIPMGLARRVTKDTKFRGYLIPKGTEVYPMLGSVLRDQSFFACPQDFNPQHFLDEKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFLTTILQNFRFQSPLPKEAIDISPKMLSLKYGPVYTFHLGSRPCVVIAGYQALKESLIDRAEEFGGRGEFPAVQMWSHGDGIVYGKGERWKQLRRFAIATLKNFGMGKRSLEERIREEAQHLCEEFQKTEGAPFDPTFFLSCAGSNIISSLVFGDRFAYDDPKFLELMALINSNWRIMSSFWGQVSSVVEMMSGKVL
The following text describes a protein:
Function:
Plays a structural role in chromatin. Probably involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSTFPGEDTRIPKRISEALSHQPLNHLVPKRELSRLLSKPVQISVQLESEDAFEEVPEELWQYPHPIDLDPLRLEESQPLRFRRPRGARLDYREDSSEIADLPGMGQLARACLSGTQLVDSAAIVESIESNAKKRKQTLAIGDVEMVSPDKKTKVMASVSPVSLNRVALGSQHLKTLERLMQYIGADESSAEFGDFEYWITLEDRATHILSEQCIDKLHIVFRNILSIPAVWTELDVSLLQRIMDVCVSTITICLEKIELKEYSHDYTLIAFGSSMVVFFIFLLDQNDRRLQLEQYMMVPLQFLTFTADNLEEEFDRGGNGVERSLAMLHSTLDVFYMYISNKPKLDDGLVVKLVYMFTELIMSTWSHNVSSVSLQNHIGNVKTIGMKSIEVLFEKLPEQRLFIIDELLSHLDNLPNTRSQKRMKNIGKNLHITHFSYIMLSILQVWNNYDYCSNLVSPDTEQLHDLIAHHAATQSDLEFAADHIIDTILKKCFSNISKYRFVFDQFVTDMTTVVTLPDWPVSDLILARLLKKLLSIFNPQSQKHINIESVALQGIGLIGSTILDIRLSSNSNPTANLIHLFNYPEDIDGLFKAYRTCLAYCTNSVQHHTPYKFLWCKQLDVLTKLKEMDKESQGWGSKLQQKFLSLIESIHLPLEQAANLGAVEILPTYCSTLLTSELINMYEPYLKLVLSLLERHKVKLRSGAIRCLALLISKDKNMLYTPIVKETIENRLTDSSPLVKDAILELIELGSSYIDFYQHININYNDDSMLVRKHVLRMNQIIYDDTEDIIIKAYVASRILRRIEDEEDVIIETARSELLKRWILSIQCPNAKPELQIKNCRVSIRVIAQLLVGGDKICDLFEHFLIFYVLNKNAHTEDQNKLISSSLCLLTDQVIEMVIENEAADVDNQREEEGRNIMKFLSVLSSCQDSFITKDHITALYPYLHSDTKSDFQLHILKVYRNTFEQLSHFKPKFLYDLETTILSRLPRMNVRELDEAIPLSWSLSRHRKDDTRICKACASCLGQLSPYIANATTDPSAVRPDGKLQRLLYLATGFARFCSFENTEGKFPNLKTRENIFEYVTKCLLMFTKENIHHVIRRIATKNLVKIASRYPKLFNSRHVLTVLDTQFEKGILDIQLVVLESLYDFFLAEERRSLIQVGVDGTISSNNELRKVVANHTKSDSINDGICSALVSRYLDKILKICLIADLNNAMVAIRFLKQILTYGYTNPSLCVPTVIALTASPNSYMRDLSSEMFSELLQGYESMAFNCLNQGIRLGTEYAVKIRPKQFHEDSMFLRRLQQLMSTNKRNRSKFLKVVKKTVFSNYLSTSVNYEESCYHIIYLLHNLSKISYDNMLELYEMLRSVISVSEYFSDRISERLDGFQSNQNTAAEVSAIIVTRLSIEEFKRFMFEQHHLSEAKLTLLDATDDENLRNKSVAALDDQVGSLHMENIFLGYENPINNKDYCWKYISTLHRDEI
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Sequence:
MTALLELRDVSKRYRDMVVIPGLTLQVRAGEFVGVIGPNGAGKTTLFGLISGNLRCDSGTVLFDGEDVSALGADARCRAGIGRTFQIPQPFQGMTVFENALVAATFGAALHGKQAEQKAREALHRCGIEHLGDTAAGRLTLLQRKRLELSRALATEPRLLLLDEVAGGLTDAEVGELLELVTSIHRAGVTVIWIEHLVHALVSSADRLLVLSEGRLLGDGVPSAVMSSREVRDVYLGSDLDEQGSHATH
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2. Has anti-apoptotic effects in the cell. Involved in negative control of H(2)O(2)-induced cell death.
Miscellaneous:
MISCELLANEOUS: Present with 1050 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Mitochondrion intermembrane space.
Domain:
The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters; The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation; The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.
Sequence:
MSQYKTGLLLIHPAVTTTPELVENTKAQAASKKVKFVDQFLINKLNDGSITLENAKYETVHYLTPEAQTDIKFPKKLISVLADSLKPNGSLIGLSDIYKVDALINGFEIINEPDYCWIKMDSSKLNQTVSIPLKKKKTNNTKLQSGSKLPTFKKASSSTSNLPSFKKADHSRQPIVKETDSFKPPSFKMTTEPKVYRVVDDLIEDSDDDDFSSDSSKAQYFDQVDTSDDSIEEEELIDEDGSGKSMITMITCGKSKTKKKKACKDCTCGMKEQEENEINDIRSQQDKVVKFTEDELTEIDFTIDGKKVGGCGSCSLGDAFRCSGCPYLGLPAFKPGQPINLDSISDDL
The following text describes a protein:
Function:
Probable chloride channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEENYVPSLLASFYHSLPHVNITFQFVNSTFNPRSDIYLESLGVAASVPAVWLLFTLLVLLSYLLSRCCDKQLRQGRSLYCHRWVLGVTAFICSATVAVGLYGNDDVHNASVRFSSTLRAVQHNIDAVRDHSQSLKLNLETQSFPLADRLTEVVEGKLLANVTIQRLATELLHKTTANINRSTDDMNLLYERLMPTSPLPPFLTIFDAVELYRWPITMGLLSVFILLCLILIFGVVRRIRCLLVMFAVFGLLMIIISWCTASIYIALAMAMGDACVDPAGVVERLVANQYGADIADYYMRCPIDGVVKESGPLNTFVRQARLNIEKSEQLVAEFAVLAEIHYSPKDVQPSLDKLTRSLKTATQNLATLAGLVDCAPIHRRYLDILDVTCRKALFGLTFMLGSAVGAGLLFTILVWVDSHVWIYLRKRKGYLQVAEADPFLPLSSSAGSSSRGAQGGSLSRPSLNPPQTYSSAGTYPGRHAHYRHTHTPPQTPPFPGTMNGRGSHNRHEQASAPPLLLGPNNGQYPTLSKSCKTLESSDFY
The following text describes a protein:
Function:
Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle II (propionate degradation route). In vivo under anaerobic conditions, AcnD catalyzes the stereospecific dehydration of (2S,3S)-methylcitrate (2-MC) to yield the trans isomer of 2-methyl-aconitate (2-MCA). AcnD can also accept citrate and cis-aconitate, but with a lower efficiency. 2-methylisocitrate and isocitrate are not substrates.
Miscellaneous:
MISCELLANEOUS: Together with PrpF, able to restore the growth of prpD mutant on propionate.
Sequence:
MSTVMNTQYRKPLPGTALDYFDTREAIEAIAPGAYAKLPYTSRVLAENLVRRCEPEMLTASLKQIIESKQELDFPWFPARVVCHDILGQTALVDLAGLRDAIAAKGGDPAQVNPVVPTQLIVDHSLAVEYGGFDKDAFAKNRAIEDRRNEDRFHFINWTQKAFKNIDVIPQGNGIMHQINLERMSPVIHARNGVAFPDTLVGTDSHTPHVDALGVIAIGVGGLEAESVMLGRASYMRLPDIIGVELTGKPQPGITATDIVLALTEFLRAQKVVSSYLEFFGEGAEALTLGDRATISNMTPEFGATAAMFYIDQQTLDYLTLTGREAEQVKLVETYAKTAGLWSDDLKQAVYPRTLHFDLSSVVRTIAGPSNPHARVPTSELAARGISGEVENEPGLMPDGAVIIAAITSCTNTSNPRNVIAAGLLARNANAKGLTRKPWVKTSLAPGSKAVQLYLEEANLLPELESLGFGIVGFACTTCNGMSGALDPVIQQEVIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTIRFDIEKDVLGLDKDGKPVRLINIWPSDAEIDAVIAASVKPEQFRKVYEPMFDLSVDYGDKVSPLYDWRPQSTYIRRPPYWEGALAGERTLKGMRPLAVLGDNITTDHLSPSNAIMMDSAAGEYLHKMGLPEEDFNSYATHRGDHLTAQRATFANPKLKNEMAIVDGKVKQGSLARIEPEGIVTRMWEAIETYMDRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLVGMGVLPLEFKAGENRATYGIDGTEVFDVIGSIAPRADLTVIITRKNGERVEVPVTCRLDTAEEVSIYEAGGVLQRFAQDFLESNLK
The following text describes a protein:
Function:
Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription.
Subcellular Localization:
Nucleus.
Sequence:
MAKVPELEAALLQAQPSPQASPEARGASCAQLLGRGLLVHAEARGYLAGAGRPRGAAQEAEPPVGVKAEMHVSNGNFSSEEEDAEDQDGKTKAADLHLSQKKTITQMMKDKKKQTQLTLQWLEENYIVCEGVCLPRCILYAHYLDFCRKEKLEPACAATFGKTIRQKFPLLTTRRLGTRGHSKYHYYGIGIKESSAYYHSVYSGKGLTRFSGSKLKNEGGFTRKYSLSSKTGTLLPEFPSAQHLVYQGCISKDKVDTLIMMYKTHCQCILDNAINGNFEEIQHFLLHFWQGMPDHLLPLLENPVIIDIFCVCDSILYKVLTDVLIPATMQEMPESLLADIRNFAKNWEQWVVSSLENLPEALTDKKIPIVRRFVSSLKRQTSFLHLAQIARPALFDQHVVNSMVSDIEKVDLNSIGSQALLTISGSTDTESDIYTEHDSITVFQELKDLLKKNATVEAFIEWLDTVVEQRVIKTSKQNGRSLKKRAQDFLLKWSFFGARVMHNLTLNNASSFGSFHLIRMLLDEYILLAMETQFNNDKEQELQNLLDKYMKNSDASKAAFTASPSSCFLANRNKGSTVSSDTVKNESHVETTYLPLSSSHPGGLPSALHPFPAGNTDNMPLTGQMELSQSTGQLMTPPISPAMASRGSVINQGPMAGRPPSVGPVLSASSHCSTFPESIYPTHPQSNHDFYGTNSNYQTVFRAQPHPPSGLYPHRPEHGRCMAWSEQQLSRDFFSGSCAGSPYNSRPPSSYGPSSHSQDSHSMQFLNTGSFNFLSNTGAASCQGATLPPNSPNGYYGSNINYPESHRLGSMVNQHVSVISSVRSLPPYNDIHDPLNILDDSSRKQTSSFYADTSPSVACRTPVVASSLQTPIPSSSSQCMYGTSSQYPAQETLDSHGANGREMVSSLPPINTVFMGTAAGGT
The following text describes a protein:
Function:
Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MTSYTDKGEKPERGKFLNFHHIKFWVGNAKQAAVFYCDKFGFEPLAYKGLETGSREVVSHAVRQDKIIFVFESALNPGNEEMGEHMIKHGDGVKDVAFLVEDCDFLVKKAKERGAAVLKEPWVEQDAGGKVKYAIVQTYGDTTHTFVEYLGPYKGLFLPGYKEPLFRDPLLPKLPSGHLSFIDHIVGNQPDDEMVPVSDWYQKCLLFHRFWSIDDKQIHTEYSALRSIVVTNYEETIKMPINEPAMGKKKSQIQEYIDYNGGPGVQHIALNTSNIIQAIVNLRARGLEFLSAPDNYYESLREKLKTAKIKVKEDLKTLQELKILVDFDDKGYLLQIFTKPVQDRPTLFLEVIQRNNHFGFGAGNFKSLFEAIEKDQDARGNLTVLTAQNQSVSKAFQ
The following text describes a protein:
Function:
Negatively regulates expression of the nimT operon and its own expression. Acts by binding to the nimR-nimT intergenic region.
Sequence:
MMHRLNLNGYEPDRHHEAAVAFCIHAGTDELTSPVHQHRKGQLILALHGAITCTVENALWMVPPQYAVWIPGGVEHSNQVTANAELCFLFIEPSAVTMPTTCCTLKISPLCRELILTLANRTTTQRAEPMTRRLIQVLFDELPQQPQQQLHLPVSSHPKIRTMVEMMAKGPVEWGALGQWAGFFAMSERNLARLIVKETGLSFRQWRQQLQLIMALQGLVKGDTVQKVAHTLGYDSTTAFITMFKKGLGQTPGRYIARLTTVSPQSAKPDPRQ
The following text describes a protein:
Function:
5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR); 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
Subcellular Localization:
Nucleus.
Sequence:
MGIQGLLPFLKDASTQVNVKMLAGYTVAVDAYCWIYRGAFACAMDLARGDKSDMYVKFVLKYVNMLLSHGIKPVIVFDGCNLPSKQGVEDSRRERKQLYLQKGKQFLRDGNTAQARECFQKCINVTPQMAHEVMEACRALGVDCIVAPYEADAQLAYLNKCGIAQAVITEDSDLLAFGCDRVIFKLDLNGNGTMIEKHRLSQCLKIKAQNFTFDKFRYMCILCGCDYLPSLHGIGPAKAAKLLSLTNQSDMTKVLRKIGSYLKSSIVAPTEYIEGFVKADNTFLYQLAFDPMKKELVPLHEYPPGVISTDMPYAGEYKPGKLALGMALGNIDIHTGDTVRDFNPLTYKPPPSSTWHGPKNVTASTPRHKLSMWHPDYKTGPKFGTLNLKEVKTAFTKGKEVTVQAPAFLKKPEAKPLEPTDVCTDSELAALYGSPPNSAKREAKKTSVSEKGGSSNLRKRLAIIRPGSSADSASGSIVVSRHFKNSYEQAVKDLKSKNNPTDNSEQKKDTFLDMIDNDCSSEEPSRSVDVDTINDEKEEDLSLEPTEPSWRKELQSFQRQGKIGNQNDNSAKTEKRKRVLSEEDGEEETSSPENEPNVNTPEASIDSSLVNALPKLSEELFSEIPHKETPKNPFKVATPKQGSAFSWARSAEKQITLKSSVSSLGRFKYSTLSQAKRKKTSQEEVNNTTSSQEEVDSTKTSQEAVDMTGSSQEEVKNSTSSQESVGELPEEESLSKSPVGNSSLKLSHVKQSISSFDNCSVYSMDSFTPTDSQNSGSASFSQGSQYFTASEGNSTQVSTTEMSQTSGDTTKEEVTEIKEESQQPVCSQSLEDKRYSEENNIKTLMREKESARSHDALEQVSSYFEKSALPSLSQTALDQRAVVQDMGRRAMEDGMGTPRMGKPSRGKVRQVGLSRRSCPSQTKRKRNNENSSTQPKISNFLQQFSLKKDPSQKKKEEPIRKPMSPSKANVVIDCTPETEPSIAVSLNGAKVKRNIFDNE
The following text describes a protein:
Function:
Exhibits specific pollen self-inhibitory activity thus preventing self-fertilization.
Subcellular Localization:
Secreted.
Sequence:
MNIFYVIVLLSFFLSKSSGFFPVIEVRIMNRRGNGRSIGIHCRSKDNDLQNQTVTSGHDMSFSFREDFFHTTHFYCDLQWDKETKFGFYSYQAKRDDDGRCSSQCLWKIMDDGLYGFDQEHQIWQIYHLIKKERKEGRT
The following text describes a protein:
Function:
Protein component of the posterior mating plug.
Subcellular Localization:
Secreted.
Sequence:
MIRILVLMITFTLMTGSALCSIEQLMRVFGGGSVGGGSRLDINRRVTIVPPEGELSFGYGFRPGFY
The following text describes a protein:
Function:
Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the trafficking of dense-core vesicles in DA and DB motor neurons by promoting anterograde trafficking to the axon and preventing dynein-dependent trafficking to the dendrite. May regulate these processes in association with cdka-1/p35. Activity may be regulated by cyy-1. Involved in synapse formation during DD motor neuron remodeling by regulating transport of disassembled synaptic material to the new synaptic sites probably by activating the motor protein unc-104/kinesin-3. Regulates microtubule polarity in the dendrite of DB motor neurons. May also play a role in GABAergic synaptic vesicle localization in the ventral nerve cord.
Subcellular Localization:
Cytoplasm. Cell projection, dendrite. Note=Localizes predominantly to presynaptic sites and in dendrites as faint puncta.
Sequence:
MLNYDKMEKIGEGTYGTVFKARNKNSGEIVALKRVRLDDDDEGVPSSALREICILRELKHRNVVRLYDVVHSENKLTLVFEYCDQDLKKFFDSLNGYMDAQTARSLMLQLLRGLSFCHAHHVLHRDLKPQNLLINTNGTLKLADFGLARAFGVPVRCFSAEVVTLWYRPPDVLFGAKLYNTSIDMWSAGCIFAEISNAGRPLFPGADVDDQLKRIFKQLGSPSEDNWPSITQLPDYKPYPIYHPTLTWSQIVPNLNSRGRDLLQKLLVCNPAGRIDADAALRHAYFADTSDV
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
Miscellaneous:
MISCELLANEOUS: Present with 1332 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSSPINDYFIDYNPLFPIFATRIAKGLAIYRVSDHARLAVIPIRNINLVANYDWDTTTGKFLSIFFKDGTIRIHDIFKDGRLVSFLRIPSTKISKGIWDRIPLRYEPNNRDFACNIIDDLPKLIRFVKDSKRINIVPYTQPNSLWRGPDEDDLDSNEKLDVHVVFNEGNDKITVFFNGDYAVFLSVDNIENENSLKSIIKVQDGFYQCFYEDGTVQTLNLGPLLQSKSSVNLLNYIMVIKELIGYMLTHLEFINRELATPYLDFVKRLCDEAYGYGKLKSELEALFLLGEISCDLEDWLCNSVGEKNFKRWKYLGCEAYQKTVQILTLIFVPACERIIIYVEKLRAILQAFSIQNKLSYTSDLTAVEVLLKSSQKLLTMTLNSIIGLGRDETLFEKFFIWFNDRLHEALDEDYKLKFQFEDDLYFGYDLLSYFDRILSKKGTEPSSIIDVKLYRDLINSMSDMEKDIAQSNVNSHIQQHILVDLKTDVFAQKYPSSQINLLDAIKLPKHNYIVYLIQVTKHNSAQEPFSEENKKKLYIGTLKDENLGIISKESSVKIPALFKSYRLSSTRFVPNRVHSLLRDIGLSDSNYHSSHVTDYRGENYENEEDDGTIAIPAYIRENRENDDFIACTAKVSVDGRSASLVFPKEKQNV
The following text describes a protein:
Function:
Required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MFNRKTLLCTILLVLQAVIRSFCEDASNLAPVIIEHPIDVVVSRGSPATLNCGAKPSTAKITWYKDGQPVITNKEQVNSHRIVLDTGSLFLLKVNSGKNGKDSDAGAYYCVASNEHGEVKSNEGSLKLAMLREDFRVRPRTVQALGGEMAVLECSPPRGFPEPVVSWRKDDKELRIQDMPRYTLHSDGNLIIDPVDRSDSGTYQCVANNMVGERVSNPARLSVFEKPKFEQEPKDMTVDVGAAVLFDCRVTGDPQPQITWKRKNEPMPVTRAYIAKDNRGLRIERVQPSDEGEYVCYARNPAGTLEASAHLRVQAPPSFQTKPADQSVPAGGTATFECTLVGQPSPAYFWSKEGQQDLLFPSYVSADGRTKVSPTGTLTIEEVRQVDEGAYVCAGMNSAGSSLSKAALKVTTKAVTGNTPAKPPPTIEHGHQNQTLMVGSSAILPCQASGKPTPGISWLRDGLPIDITDSRISQHSTGSLHIADLKKPDTGVYTCIAKNEDGESTWSASLTVEDHTSNAQFVRMPDPSNFPSSPTQPIIVNVTDTEVELHWNAPSTSGAGPITGYIIQYYSPDLGQTWFNIPDYVASTEYRIKGLKPSHSYMFVIRAENEKGIGTPSVSSALVTTSKPAAQVALSDKNKMDMAIAEKRLTSEQLIKLEEVKTINSTAVRLFWKKRKLEELIDGYYIKWRGPPRTNDNQYVNVTSPSTENYVVSNLMPFTNYEFFVIPYHSGVHSIHGAPSNSMDVLTAEAPPSLPPEDVRIRMLNLTTLRISWKAPKADGINGILKGFQIVIVGQAPNNNRNITTNERAASVTLFHLVTGMTYKIRVAARSNGGVGVSHGTSEVIMNQDTLEKHLAAQQENESFLYGLINKSHVPVIVIVAILIIFVVIIIAYCYWRNSRNSDGKDRSFIKINDGSVHMASNNLWDVAQNPNQNPMYNTAGRMTMNNRNGQALYSLTPNAQDFFNNCDDYSGTMHRPGSEHHYHYAQLTGGPGNAMSTFYGNQYHDDPSPYATTTLVLSNQQPAWLNDKMLRAPAMPTNPVPPEPPARYADHTAGRRSRSSRASDGRGTLNGGLHHRTSGSQRSDSPPHTDVSYVQLHSSDGTGSSKERTGERRTPPNKTLMDFIPPPPSNPPPPGGHVYDDIFQTATRRQLNRGSTPREDTYDSVSDGAFARVDVNARPTSRNRNLGGRPLKGKRDDDSQRSSLMMDDDGGSSEADGENSEGDVPRGGVRKAVPRMGISASTLAHSCYGTNGTAQRFRSIPRNNGIVTQEQT
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
Subcellular Localization:
Cellular thylakoid membrane; Peripheral membrane protein.
Sequence:
MKGSLYSSKIAEPYAQALIGLAQQQNLTEVFGDNLRSLLTLLQDSPDLSAVLSSPVVKDEDKKSVLRSVLGDGGNGYLLNFLMLLVDKRRIVFLEAICEQYLALLRQFTNTVLAEVTSALKLTDAQKDQVKERVKQLTGAQAVELETKVDGDILGGIVIKVGSQVFDSSLRGQLRRVGLSLGTAL
The following text describes a protein:
Function:
Golgi membrane protein involved in vesicular trafficking and spindle migration.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MTGAERRNHPGSLGALPARSPLSRSPSPHKKAHASASNVITQANVCSILAQRTNQHPHFDTPISKQPDFVQAFGATPNYELPPDGLFEASQPDPASSTAATAATAAASSSSYWLSANNRPRSVPPRIALESSNTRSTNPRRAVPLIDTSGRPHSRRESLMEQAEKRPTSPHITSATPTSARHHLPFSLQQSQKQSTSRSASFHEHDVHPSHQAHGQSAHRVASPSLLNSGIGRAAVSAAQSIMDAMAGRSSPVTLRSAHPSQDGRDSLSDDEAGKGHGRKAAASVAARFTPSIYHPRHPAPHHHAASLHDKQRPTSPHAIGADIAWRASISESRRATPAAYRPQSASANRRRNSALIDQQPAAIGDDSTDMHLPNSYKSTHSSITIGSPIVIPQARRGAVRLRPSRKRRITRQVKPTRTFRQTILISIATLAHFFRLLASPTEAFRRFTEYCIDTRIAIDDAFRDPQTGLRSYYPPWLQAYVPLLIWLGISLSSTALVITFHTQVFVGLDHMSTYLQGLGLWGKVMLGSLIFLTTFPPLPLYSTLIMLCGFTFGLWQGFIISYIAALSGAIVVFTLSRSLLREWMVGLLNKSGGLKKVVRAIEKQPKLLFLVRLAPYPYNLMNTLLASSPTLTLRTYVTCTALALPKLLIHTGLGTSIKNFAAYNGAGEAQSKEDAQASQTAEHVKKWAGLIGAGLCFGIMIYLLSVARRAVDELDDEGADGYYDDDVLYDDQDEELLSTDDDDERHDGDDSLDHGQGVDMRERVGPSTLGFRNGYAPITSSPEERFRQSMRHPQAVPGPLVLPGSSYDPAASGSGSFDGSASVGNRSVDLVDKIAEMEAHAENMQFESPLHQGSEQEHVAGTMMASAKWSHMVADLEESVITNDTVTNKGRIVFLDQDGTDEADEYLE
The following text describes a protein:
Function:
Histone demethylase that demethylates 'Lys-4' (H3K4me) of histone H3. Involved in the control of flowering time. Has a suppressive effect on floral transition under long day conditions through the demethylation of H3K4me3 in the promoter region of the flower-promoting signal HD3B/RFT1.
Subcellular Localization:
Nucleus.
Sequence:
MPPQPPPAASASASAPDPAVPAWLRGLPRAPEYRPTESEFADPIAFLSRVEREAAAYGICKVIPPHPRPSRRFVFAHLNRSLVSSCDAPAPSPAAASDSSIPPSSSSPPPVSAAVFTTRHQELGNPRRGRPTPQVLKQVWQSGERYTLDQFESKSRAFSKTHLAGLHEPTALAVESLFWKASADRPIYIEYANDVPGSGFAAPVQLQRKKKQKRETAPMDEWEKSSGWRLSNSPWNLQAIARAPGSLTRFMPDDVPGVTSPMVYIGMLFSWFAWHVEDHDLHSLNFLHTGAPKTWYAVPGDRAVELEEVIRVHGYGGNTDRIASLAVLGEKTTLMSPEVLIDNGVPCCRLVQYPGEFVVTFPRAYHVGFSHGFNCGEAANFATPQWLKFAKEAAVRRAVMNYLPMLSHQQLLYLLAVSFISRNPRELLSGIRTSRLRDRKKEDRELLVKQEFLQDMISENELICSFLGKKSVDNVVLWEPDLLPSLTALHPCSSCSKAPEKKGEDGPRIGSTQSSSKDDSSSDGTACMTGTQSKGLSMDSKQAPEGEKLDTDDGDDLPFDLSIDSGSLTCVACGILGYPFMAILQPSRKALEEISLVDKERYKLSCEKEICSNVLPCSPNDGSSGCPLIANRSSSPVENANLSHQDVKPIRSDISLMGKEFNGTLGKHIGTSCSCSSENTIHPYGDTETPEKKIPSDCPGSELSKQSGRGDVNVPDVEGSEETISWNTGCAFARPRIFCLQHALEIEELLASKGGVHALIICHADYVKLKALAISIAEEIEFQFDYKDVALANASKSNLHLINISIDDEGYEEEGTDWTSRMGLNLKHSSKIRKETPESQEQPPLSFWGLFSKPSPISVVSNLKWLCRKARTPYKVIGYASSPDVVATPDKVKPAVTKTQIDTSGNAHENIGSEQTLQQDCVLQESNDVADMCKRPKVNDQDGHSLINIPIAVAEYPMMHQVCERPVSVSACDDPICSFDSQDSPTTVAVSAGKPTREQCGAESTELSTVKQFLDNGLIAEGGSMNFISNHEHLESDNATSVCKDEQLQVQQDQLAMVLCNNPNTELVAGELHGGAASSTLENEDSCGNTSYCSDTVLKNSEPDTDDQPETCDRSVVLVTPKSSCDQMISSSDRSCSLTLDCPVSTDAAFSSEKLSMAHDLMGSELQAVHNSKAEVVASLTDVKGAKLNSIHTTQLPHESPSSDFIISEGAQSASTTAIPRKNGTSMHTESNSIDILLGVLADESKVSSGKDEVGKASLTLMTLAGNDQSADDVTQDEVAEITDPSHGFCSSDIVSRSIGSSNRTNIICYARRKHKRKSGSEFNINSPQSLGSFVRSPCESLRPRTRPAIVEDMTNETKTAEASTANKRKKAKVEAFQCDIEFCDMTFETKAELRAHQRNICTDESCGKRFSSHKYLKRHQCVHRDERPFKCPWDGCPMTFKWLWAQTEHIRVHTGERPYKCSAPDCGQSFRYVSDYSRHRKKFNHY
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus.
Sequence:
MSYNPRMSMAPRGTSTNQRAPAGNEHDAFMTLPDNEIAGCITDIGIKFSVQDLQKPNPQIIQKVFEWLAELLMNTTREVVAPAMRAAAEDMCGDDAERIFTSDTRDLMGFFVVLRKLLREVSCMLWNTLLNVADRWNQCGIHDFTFNDLYKPTHGRLVKIFSYMINFIRFRESQTEVIDEHFNKAERTKLRIEQLYDDKQAKELQLADLERNRAATQRLMQEKEKRNNDIKNRLRELKNAQEAVAEKLERARAEQNRLKELLQQKAENKENVQREVLKLKPYTQQSPTALEESLRDLNDRLTGDKAQIDTLDRRARALQTSTDSFGVVATDVTSCTRLLTDVQADLTKEEEELAKAARHRDALADRSNNVRDVERQERLLQKQLGNINARTDKLKTKADEEAERARKRMEELRDTHSKLAEERGEKGREMERRRVRIEQTEKKMAELKDNIENEVHAAHDEYLKMESHIKLYITDMEQAI
The following text describes a protein:
Function:
Catalyzes the phosphorylation of pseudouridine to pseudouridine 5'-phosphate (PsiMP). Catalyzes the first step in a pseudouridine degradation pathway. Acts together with the pseudouridine 5'-phosphate glycosidase PUMY in the peroxisome to prevent toxic pseudouridine monophosphate accumulation.
Subcellular Localization:
Peroxisome.
Sequence:
MEPVIIGALILDVHAKPSTTPISGTTVPGQVLFAPGGVARNVADCIFKLGITPFMIGTLGLDGPANVLLKEWKLSMKGILRREDISTPIVSLVYDTNGEVAAGVAGVDAVENFLTPEWIQRFEYNISSARLLMVDANLSSLALEASCKLAAESSVPVWFEPVSVTKSQRIASIAKYVTIVSPNQDELIAMANALCAKNLFHPFRSDENKLSIEDMFRALKPAILVLLKNGVKVVIVTLGSNGALLCSKGNPKKALNIDRKFLRSGEVFKRVQSVCSPNRFSELGSNRSPSLFAMHFPTIPAKVKKLTGAGDCLVGGTVASLSDGLDLIQSLAVGIASAKAAVESDDNVPPEFKLDLISGDAELVYNGAKMLMVHQSML