lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 22 (m1A22) in tRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MNELKLSKRLQTVAEYIPNGAVMADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKSGLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNIHAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFLAKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSSKNKQSFMNRFIAFMEKYFEPVAARIEKQRHISSIKNGMIALISVLIIGSFSLIISAIGNMFPAGSVVKEFFVQNAAALNLPFQFTFGLLSIYAAITISYSHAKQMKVPVLHSVMAAVMVTLILNTKMVDGVLNTEFLDSRGLFIAIFAALISVELIGLFIRKNITIRIKGLPAGIATTFEAIIPLVVLLFSAVGLSILMQSVTSGQIIPEAFTTMLAPAINSIDTPYAVFLICFLEMLFWFIGLNGYAILIGFVLPFMTQYLGANAAAYAAGEPIPHVFAPNFWDYFMGFSGSGITGALVILALFSKSRELKAVGKVSVVPAIFTISEPVVFGLPICFNPYLFIPFVLGTPILAVGQWFVFHFGWVRPPIANVGGTPIPLAQYLATMDWRAIILIIFVLAAAVCMYYPFFKMYEKSLIKEEEVVSERQAAHDALDLDF
The following text describes a protein:
Function:
L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists. Required for response to mechanical and osmotic stimuli.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MNKNLLVFGFLIFVKIGETSKKFPLRAFVASTDIDNDTAHAIIEMLRLAEMTFNALSDVDFDVLLGTRDLPPMEMATMMWNLNRIICDEMKLGYMLMLAGTNFKNYGIYEDIANHMKMPLIDWEPSKSENIGKTTENNPMIFSVAPSAEQLLIDYIQYKGWRDVVYIHDGKNADRTLRTMFSYLHEKSPKYQLFVDNYVAPSDEEMFKEFLNEFHRRISTQHTLKSNDSSEEIDEPIPVNVIVDLEGSYRTRAFLRALEESVLVKKEYHYVFSNFDVDETDLSGFHFSLINITIFRIFDKNNKKFLKTRAEFHDVYRGGFSNTDSIPTAAAFAHDAILVAGKALQIAMNEHGKGIFDKSFVRHQLFNRGRKGLYCRPHEDQTESRQFETFEHGKKIAEAIKKVVLTDKDGTLTGRIQFDKVTGKRTNFSAEIVEIKPGVNSLNSIWERFQWAEGEGFLLGGERYVQEKKKDSSQTRKGILPSKPWQLRFNVVTVLVKPFVMLKRRNPGEPELKGNDRFEGYCIDLLNLLAKNITGFEYDVFISDGNKYGSRQADGSWDGMIGYLLNETADVAVAPLTITQERERAVDFSKPFMTTGISIMIKKPEKQEFNIFSFMEPLGMTIWIFTLSSYFGVSLTIFLVSWFSPYEKRIEFKRGEFTVTNEFTLYNSLWFTLAAFMQQGTDILPRAVSGRIASSCWWFFTLIIVSSYTANLAAFLTLERMTPPIESVEDLANQNKILYGVNEGGSTAAFFEDSIVPLYKKMWNFMVSTTQKQIELEKQSITNSTSNRIFVSSYADGIEKVRTSKGKYAFLLEETTNNYESGRRPCDTMKVGQNLNTLGYGIATKIGNPLRVSLNLAILYLSEKGELKKLENKWWYDRGQCDTGTSDGGTSSSLNLSKVAGIFYILLAGMVLSMCTALVEFLFRKNKENREKERNRMRSSRPLKPGILASCERAKQKQLQNRRTKSEEVSTPRSTLF
The following text describes a protein:
Function:
Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
Subcellular Localization:
Cell inner membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein.
Sequence:
MAFGSFDKNENSVMSEINVTPLVDVMLVLLIVFMITMPILTQSIPLELPTSSIEKKDEPKDIFRVAINPTGIYLGEKLVNEEELKQSFLTKFQENKNTVIAISADISVEYQHIVKVLELAQNVGLTKIGFVTQPSK
The following text describes a protein:
Function:
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Endosome membrane.
Sequence:
MGVPRPRSWGLGFLLFLLPTLRADSHLSLLYHLTAVSAPPPGTPAFWASGWLGPQQYLSYNNLRAQAEPYGAWVWENQVSWYWEKETTDLRTKEGLFLEALKALGDGGPYTLQGLLGCELGPDNTSVPVAKFALNGEDFMTFDPKLGTWNGDWPETETVSKRWMQQAGAVSKERTFLLYSCPQRLLGHLERGRGNLEWKEPPSMRLKARPGSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGSGEGDFGPNGDGSFHAWSSLTVKSGDEHHYRCLVQHAGLPQPLTVELESPAKSSVPVVGIVIGFLLLTAVAVGGALLWRRMRKGLPAPWMSLRGDDVGALLPTPGVPKDADS
The following text describes a protein:
Function:
Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
Subcellular Localization:
Cytoplasm.
Domain:
ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site; The C-terminal coiled-coil domain is crucial for aminoacylation activity.
Sequence:
MNEDQFPKAYDPKSSETGVYSFWERSGMFVANASSEKPAYSIVMPPPNVTGILHMGHALVNTLQDTLIRYKRMQGFEVCWVPGTDHAGIATQTVVERHLKASLGKQRTDFSREEFLKHVWDWKEKSQNVILSQLRQLGCSCDWSRQRFTMDPGANRAVKKAFKILFDKGVIYRGYYLVNWDPILQTALADDEVEYEERDGWLYYIRYQVVNSEEFITVATTRPETLLGDTAIAVSPEDLRYSHLIGAKVVVPFVNREIPIIGDFSVDASFGTGAVKITPAHDKDDYKTGMNHQLPMINILTPTGEINENGGIFTGLSREVARENIITSLEALGLFVKKEAYSSRVGVSYRSGAIIEPYLSKQWFVSVDSFRDSLRGFVNSEEIRIFPPEFVRNYLTWVNNLKDWCISRQLWWGHRIPVWHNKHDENVICFDGEGGPEEVMRDPESWYQDPDVLDTWFSSGLWPLTCFGWPDENSLDLKKFYPTAVLVTGHDILFFWVTRMVLMCSAMVDTEPFSDVFLHGLIFGKSYREYDEKGEWFYVSGERKRDYDKGKALPKNVVAKWEKLSKSKGNVIDPIEMIEAYGADAVRLTLCSCANRGEQIDLDYHLFEEYKNFINKLWNGARFIFGHISELTSRDLEEGVNQDLLGLEDFYILDRFNELLDLIDGHYNCYSFDKIASLAYDFFKNDLCSTYLEIIKPTLFGKQDSDQQRATKRKLLATLLINILGVLHPIVPYITETLFQKLKATLGTVENGKGDSVTGHAVSMLRSEACMVAEYPKPIHVAFPQGLRESFGIAERLVYTIRNIRGEMQLDPREPLQAFVISSEKKELVDVCIPIMCALGGVKTVEQLAEAPKDSIFSLGVVEGIQVGVILPPEHLAKERVRLEKEKTRLEKSIDSVSKLLASEDFRTRANPSLVQAKKDSLRNSQRELQSILDKLASL
The following text describes a protein:
Function:
Plays an important role in nitrogen catabolite repression. Down-regulates the expression of many genes involved in nitrogen utilization by inhibiting the GATA transcriptional activators GLN3 and GAT1. Under good nitrogen conditions, binds to the phosphorylated forms of GLN3 and GAT1 and sequesters them in the cytoplasm, preventing transcription of genes expressed upon nitrogen limitation. Is also an atypical glutaredoxin without a catalytical cysteine residue. Has glutathione peroxidase and thiol:disulfide oxidoreductase activities in both native and fibrillar form. Also shows insulin disulfide reductase and dehydroascorbic acid reductase (DHAR) activities.
Miscellaneous:
MISCELLANEOUS: [URE3] is the prion form of URE2. [URE3] is the result of a conformational change of the cellular URE2 protein that becomes self-propagating and infectious. This conformational change generates a form of URE2 that assembles into amyloid fibrils. [URE3]-aggregates sequester soluble URE2, which then fails to retain GLN3 in the cytoplasm, resulting in GLN3 activation and consequently derepression of genes that are required for utilization of poor nirogen sources. [URE3] can be cured by GdnHCl and by deletion of the molecular chaperone HSP104, which is required for [URE3] propagation; MISCELLANEOUS: Present with 7060 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Domain:
The prion domain (PrD) is a Gln/Asn (Q/N)-rich domain, which is unstructured in its native, soluble form, and which forms a parallel in-register beta-sheet in its amyloid form.
Sequence:
MMNNNGNQVSNLSNALRQVNIGNRNSNTTTDQSNINFEFSTGVNNNNNNNSSSNNNNVQNNNSGRNGSQNNDNENNIKNTLEQHRQQQQAFSDMSHVEYSRITKFFQEQPLEGYTLFSHRSAPNGFKVAIVLSELGFHYNTIFLDFNLGEHRAPEFVSVNPNARVPALIDHGMDNLSIWESGAILLHLVNKYYKETGNPLLWSDDLADQSQINAWLFFQTSGHAPMIGQALHFRYFHSQKIASAVERYTDEVRRVYGVVEMALAERREALVMELDTENAAAYSAGTTPMSQSRFFDYPVWLVGDKLTIADLAFVPWNNVVDRIGINIKIEFPEVYKWTKHMMRRPAVIKALRGE
The following text describes a protein:
Function:
Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
Sequence:
MNTEHPPDAEYMQLALNEAAKGLGRTSPNPPVGCVIVRDGEIASEIVGRGFHPKAGEPHAEVFALREAGERARGATAYVTLEPCSHDGRTPPCADALIAAGVARVVVAAGDPNPQVNGRGLEKLRAAGIEVATGVLEAAAVRQQAGFRSLVTRGRPHVIYKYAMTLDGKVAALNEGNGPVSGPEARARVMAWRNEVDAVAVGARTALLDNPQLNVRGLDGGRDPRAVLFDPEGHLPASARAVREGTVLVLREGRSTPLERDPRVTVLHAHSLQGALEQLAGLGVATLLLEGGPTLASAFFEAGLIDELRVFVAPKLLGAGLSPLLAPVRSMHAATELAVERVEVVGNDVLVIGGLSV
The following text describes a protein:
Function:
Forms chloride channels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane.
Sequence:
MTVTYTARVANARFGGFYKLLLLWRGSIYKLLYKELLAFFIMYLALSITYRFFLNEEQRLYFEKVAIYCNNYANLIPVSFVLGFYVTLVVSRWWNQYLSIPFPDRVMCAISGTVHGSDEKGRLYRRTLMRYCSLSGLLILRSVSTAVFKRFPTIDHVVEAGFMTRLERKKFENLQSSYNKYWVPCVWFCNLAAQGRSEGRIRDDHSFKMLMEELNTFRGNCGMLFHHDWISVPLVYTQVVTIAVYSFFLTCLIGRQFLDPSRGYPGHELDLYIPVFTLLQFFFYAGWLKVGEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYSDVPPMEKDRYWNHSDPRPPYTAATLFQKHLPSFQGSTFNMAIPKEDMQFQPLSDIEEMNEDTLTHTLPLFSRFPPGIGPSPLSSSAGLSTLFAAPGSRLTLLSHSTSSFSSSSVFQFPETVQDPPNNLVDPTAPGLNVQECPLEKLFSIGSQNSLFHPPKTMDGCGNVQSVMPEEAEDAASLVAT
The following text describes a protein:
Function:
Could possibly oxidize fatty acids using specific components.
Sequence:
MPHRCAAQVVAGYRSTVSLVLVEHPRPEIAQITLNRPERMNSMAFDVMVPLKEALAQVSYDNSVRVVVLTGAGRGFSPGADHKSAGVVPHVENLTRPTYALRSMELLDDVILMLRRLHQPVIAAVNGPAIGGGLCLALAADIRVASSSAYFRAAGINNGLTASELGLSYLLPRAIGSSRAFEIMLTGRDVSAEEAERIGLVSRQVPDEQLLDACYAIAARMAGFSRPGIELTKRTLWSGLDAASLEAHMQAEGLGQLFVRLLTANFEEAVAARAEQRAPVFTDDT
The following text describes a protein:
Function:
Probable transcriptional regulator that is required in neural development for the normal formation of sublateral cholinergic motor neuron processes. Plays a role in regulating the expression of acetylcholine transporter protein unc-17 in the sublateral processes. In particular, it is required in sublateral motor neurons for a left-right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis.
Subcellular Localization:
Nucleus.
Sequence:
NLSSIHHLQNLHSQHQSTLFNSNHSTPFSVTDILSPIEESYRKLELNGNPPSPFRSNSSSSSINSPGTLTTSTMANPYAMGTLYHSPGVQTYCGPTDNLSLAGHYTDMRNSASWYGSTANDPRFAISRLMSSSASGTMSHMGNMSGLAACSVSDSKPLQFPLAQRRKRRVLFTQAQVYELERRFKQQRYLSAPEREHLASLIHLTPTQVKIWFQNHRYKCKRQAKRKAMAEQNQHNQPASSPRRVAVPVLVKDGKPCSGNNSSSQSQQHGTNSTSAGNNTGSANNGNANSGIVSVTANVSGGLNLITGDAPNSHSPDTSSSLLASYGTVGGSNVAMLQQPCNNTLMSNSLAMAYRNQNNFIFNGHQQQCGGYLPLQGRAW
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MTDQRAKEYFDQLQTAIDEERTSDIIDISTQILNFMPGDFELLLCRGIANLQEGEYEDAWNDIKGLKGCEFEKAYCLYKLERFQEAIEIYNKVSNDMKNEERFIHLAAQILFRLDKGAEVLKLYENLPKDDDNYEDVLVNISAACAISHNSSVALSKVTEDSQAEQIYNTTIALIEDGQKDKAIEFVERGYAMIEKKDSLIGQLFDILRSIIPSIPAGSDFDPAKVLLALAENENANKYARTVAACDYVAINPDDRANHKKFRHLYSDVVTNGIRKTEVEGFLVNQFVLAHMFGETKKTQGIAGEAAKLTVIDPLIAEAFARTVDPTKATKTQYSDLFSAQAKIQESKYVEAAQILAASSFAKEPRTIAVIAELYIAGKDEDAAIAFLKKNESDNADYLEFACRFALKHNHPQDAAKWANTLTKATGNAPWSVALLATSYATIDLEMAERYANRLKASGISDAEADNLEKATLVDKLTTRANDNAEPTTAFDKVMAKPKGKRDLESMSEEKRKAIKDKHRRRRRLQLPRNYDPNRKPDPERWIRKSQRAANRNRRKAKAPVAKTAGLGGKVIEAPKNPNQNKKKGKKHRW
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MNSVHQRRTPFSIADILGPSMVPEAPSAPQLPEAGPDPASPLCALEELASKTFLGHSPRATPQPSEGRAAPEAPPGPGAGVRRRRKSRTAFTAQQVLELERRFVFQKYLAPSERDGLAARLGLANAQVVTWFQNRRAKLKRDVEEMRADVASLCGLSPGVLCYPALPDSTSSPDPGPSGPDSEPNLSDEEIQVDD
The following text describes a protein:
Function:
Thylakoid-determinant subunit of high molecular weight LFNRs-containing protein complexes.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side. Plastid, chloroplast envelope. Plastid, chloroplast stroma.
Sequence:
MQGALFIKPTILLPLPSSVSSPKLTFLLPHATKASRLSSLRSNNSSSSSSLTSDPNTVDYNSSILSVFPAEACEVISGYACSADIYPEVKLDTKPVSRPVASEPVDREYEEYNSPKTVFREEACDDLGGEFCEPDFQKDAN
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
PDMTNKDDVPPKINKWDGQTVKNTLDDEIRRVLNNLSGWKEIHSLMNGRLIISFIAVCFSAVAIVYDYYHPFPKSKIILAICSVSYFILMGILYLYQWYVERNTFYQAQEVITSSKKRQWKWNSDLPSYDDKYTISAEYYADGRSGKGSVTKSIANFFDEDGQVVRPRVKAEVMDLYKRLASKDE
The following text describes a protein:
Function:
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Sequence:
MEESKENITAELKPAEDPTSTESESNGWRVVGNSENEDTTKAPISVEPKSVKTAIQEEAKMFEELSITETSHDETVMATQDIADKIQDTAISETVTEDTATEKDEMSEESSITKTDETIMATQDITDKIQDTAICEPVTEDTTTEKDEMFDKSSITKTDETVMATQDIADKIQEPTISETPPPDKTTEKDAILEAISMNEVDSTTSEITAAAETAEVEEAVTGMSEEMAKVTTSSAVEMSTKSLSEHADTTTSVAETTAVGGTEVRLVWKGEVRGDVFVQGSWDGWRQSYKLNKSVNGEHSVTLTLPVGLHEYKFRTGDSRFYDETKPAMLNVFVTLNNILQVQALPERAMKVVPNIENKSNEELVNEAAQPMKAPPLEALPDVHEKVKSSNFNETTEVTETDEQTVANMMKKLITTTATVNESVEGVEKPKEKTTLPDKTDEKMAHDIMETLEQMEHVVTTITTVEAAGSVSSDTDQMLKVISHTDKTLPDEMDGGVIACKDDTPRENICTKLTPDETTVRTEQPEPKTLTETTSAVEAAEEVLHDTEKASEELTSYTTLQDEIEKSSEPFDSEKSGEKSCPETPTDGAPSDATDTDNIIKTEDGSSIEIPAPDVSVEMTPAHEMQSAVDHAAAETSQDKTQDETVSQKEETSYDNDDSTEPLEEKLENTTVDSLNHNTKDETPPSNETVDEAPTDKDKKLEDAAQKETHVSNETASNSHEQMADKIADTALTQTPYPELRVEKLRDTATIEGLPEKTWVRIALHDYAHIKLLWKGEGNGGDLYVQGSWDGWRRSHKLKRGEYSVTLKLPTGLHEYKFRIGNNWFHDNSKTTVANCFNTLNNVINVTMTT
The following text describes a protein:
Function:
Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.
Sequence:
MIQAVLFDLDGTLADTALDLGGALNTLLARHGLPAKSMDEIRTQASHGAAGLIKLGAGITPDHPDYARWRTEYLDEYDSRYAQDTTLFDGVNELIAELGKRGIKWGIITNKPMRFTDKLVPKLGFIIPPAVVVSGDTCGEPKPSVKPMLYACGQIHADPQHTLYVGDAERDIQAGRNAGMTTVLAEWGYIAPEDDTGSWQADFHIRTPLDLLECLDKIQP
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MAQDMTEKDLLKMEVEQLRKEVKTERIMVSKSLPEIKSYTESRMTEDPLIKGVPEDKNPFKEKGGCLIS
The following text describes a protein:
Function:
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity).
Sequence:
MFGWFKGRRSKETLKDRLELVLAYDRAKIAPGKVEALRNDLLEVVQKYFPSGNSKVEVEQDGDKVVLMASISIEEASLSTEEESAAEDKSDKPSA
The following text describes a protein:
Function:
Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MENAGTALLNGSATRGSGYSFRRAVTQRLLQLSTIHLKDEDFVKSVRQLDSRNFAVDHENIRQLQIDIRTDALWTNGTVIREFSEFASHLETIQTLLNRLNSLYSQRETSVLEKLSGVQQLSEKYKTLEDQKAEALRKLEYLQFCRENFFLSEEDVYHLVSSDIVDQRFYSILEKAQTISNNCTSLFAINAEETNEAATKVMKAMSQYIDEAFEKLFRYVKTELNDMETSRNLEFHPDLKSAFAALFAKPEMLNKTLDLIVQARQRVLYVAFVMALETGDPNTFSRPIELSAPDPKRFVNDIIAWLHQTIAGEKELIETLFQARRKKINESENSWWDSLESLEMNSKMLMDENLYGVCKAIVSRVQTSILETEDLITIYGLIEIFGFYRELLSSTIHEHSTVLTSLKTLEDFAFKRLQSLIDDELYHVKASALNIPADLLPPQFVIRFMKSLASILNVRKNSYSSQFVDVNELVATLESTVSSLFEISDRCSKRLLPHKRYIFLLNVVDCCYSYIEPYSGTESLQKLLNDKQAKLADELTLQLHTEFCSQSSLIDLSFCFQSGDESFIEEALEKVNWSKIRNEFGSFLVTTFADATTDLLLLTSPTVQTNVQANSVQLFFNDVTKVKNCLEKFSKSSEFPFSLNELQIALGIENTA
The following text describes a protein:
Function:
Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6-dihydrothymine (DHT).
Sequence:
MDLSCSYVGLRLKNPIIIASSGLTENLKNMKKCEENGAGALVVKSLFEEEICRVSPTPRFEIISRSMGPLRSQTFYSFEQASPFEPEEYFKEISKALSVLSIPVIPSINCITDDGWLKYSKMAEEVGAPALELNVSCPHASISFRGQDVDETILHVARIVRENVKIPIVVKLPMQLSSPLAVAKALENIGVDGVVMFNRLTGLDINLDTEKPILHGGYAGHGGPWAFNYVLRWISTSRPHLKLSIAGSGGVGSGDDVAKYILTGADVVQICSIVYLMGYEIIPRIIDGLKKFMENKKYSTLSDFRGKVSGKVILGNYEIDRRHLYEAYINSDLCTSCGICKKVCIYDAPIEKDGKYFITDLCDGCGLCVRLCPTKAISMVFVGGRENAKN
The following text describes a protein:
Function:
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Sequence:
MAGARESLQVNEPKSPQGGIGLTRTPKKTIILQKQVRVLLPFVIKKNKQGQMMSPQNLSENNSNNEENPEVKRKRRELETPEIEATFPKEECSPHKSSLGPQTEQSLGIPGNTKDVLDFSTEMQSNQDGDGDEIETADLDGSTELSAYEKKRLKNISENADFFASLHLVETAARLREMITKRPSHGIKRKKPVKAEDDIVCRRSMRLLKVDPSGVPLPDPSPQPESVVEQNSRLPPGPLEMIPENQNGENEMFKGLLQMWMKISQPRNKSIKKLSSMKRYKASLSGMVINEANICKVTKTRICSLAIHPSETRTLVAAGDKIGQVGLWDLTRQPKEDGVFTFILHSQLVGCLNFSPTNPAHLLSLSYDGTLRCGDFTRAMFEEVYRNEERDFSYFDFLADDASTLIVGHWDAGVAIVDRRTPGTSYEQFFNSNMSLIRTVEVHPMNRHYFIAAGARDVHIYDLRYLKPRGMKPLISLTEHMKSLASAYFSPVTGNRVVTTCADDNLRVFDTSCMVSNIPLLTRIRHNNNTGRWLTRFRANWDPKQEDCFIVGSMARPRSLDIFHESGELVHSFIDEECLASVCSINVMHPTQNILAGGNSSGRIHVFKG
The following text describes a protein:
Function:
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity. Directly binds some unknown ligand, activating the nucleotidyltransferase activity, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the immune response via activation of the NF-kappa-B transcription factor.
Sequence:
MVDENLYRIKKYSDDTAFSCISKHFITLKDEEIKANNQHLHNVVSQGLIPLMKEDTLFKDIYRNIKYEGSYFKGTKVAKPDEYDLNLSMKLPLNYNELQVETNHKHFSYVKIKVNSESKLPKWEEHSKILNKWLSDKNYLNQNKFHQWMEAIMTNTYKKLKKSDNFYELEVDGKNYRIKQFKKSGPAFTIFVELGDHPTLMSMDIVPCLELNDIILQGYKTFPDVSPSKCVVAKPISKEPEGEFLWRLSFYEQEKQILSNSEVSKLKVVVKMIKKLRDQLNYKPLASYYIETIFLHEIAKRKSDVDFFRASKTSLFIYMLQKLIQALEKKCIPYFWHEGHNLIGHLQPPVIENYANRLKNILLSIDKKIVDDRFAMAEFLLNEEEKKNLLEIVESSKTNGSDTQNLEKSEVIKKIKHVINDGKNKENQNSFATIVTHAIIDRKENDLERRIAFVCEELKNLGQMKEQIPLADLNKLSESFKIMFS
The following text describes a protein:
Function:
Converts sphingomyelin to ceramide.
Subcellular Localization:
Secreted.
Sequence:
MGSLFLTFVGLSFVILINHSIQGAPPGEQKSILPSCSLCNLVVRGIFQSFEIGLTDEDIVDNIALTCISRSLYDEEICRGVASAAIPTVRYIYNNSLVDPGNVCGILMQEANCTFSDREKLEWSIAPSSIAKPDVVQLTLPSAEMPTIKVLHLADPHWDPEYMEGSNANCGNPLCCRASSGPITQSEDSAGYWGDYRKCDLPWRTLENSVEQMSKHHLDSAYIIWTGDLVPHDIWSTSREENMLIHERLLNLVKRFFPDTPIYPTLGNHDAHPVNTFALPEITDQELGTGWLYQDAERLWTKFGLPSEASSTIRHGGYYTALVQPGLRIVSLNTNYCYTFNWWTLSSAKDPASLLSWLTKTLEAAETAKEKVHIIAHIPPGNGDCWTIYCREFDKIINRFESTVAAQFYGHTHNEEFKIFYDEANDTRPINVAYIAGSLTSFTNLSPSYRVYTIDGQRPDSSWSVLDFSTWTMNLTEANEKGPMHLPEWFELYQAKKEYALADLSPKTIDEFFSRMLNDDALFQLYFKNYYKATDNFVSEGCDEECRKKILCRLVTNMSNNSNSNVKYDE
The following text describes a protein:
Function:
Serine endoprotease which cleaves preproteins at paired basic amino acids. Processes FMRFamide-like (flp) and neuropeptide-like protein (nlp) neuropeptides. Probably by processing flp-1 and flp-18, modulates the neuronal excitation-inhibition balance and thus the level of activity of the locomotor circuit. Regulates sensitivity to mechanosensory stimuli. By processing neuropeptides, modulates basal acetylcholine release at the ventral cord neuromuscular junctions. Probably by processing flp neuropeptides, regulates the turning step of male mating behavior. Cleaves pro-insulin-like proteins ins-3, ins-4 and ins-6 into their mature active forms. Together with convertase kpc-1, cleaves pro-insulin-like protein ins-18. By controlling ins-4 and ins-6 processing and thus the activation of the daf-2/InsR pathway, negatively modulates synapse development and synaptic transmission at neuromuscular junctions. Similarly, by controlling ins-4 and ins-6 processing, negatively regulates dauer formation under optimal environmental conditions. Under adverse environmental conditions, may promote dauer formation by processing ins-18, a daf-2/InsR antagonist. May cleave dense-core vesicle membrane protein ida-1. Involved in egg-laying, fat storage and locomotion.
Subcellular Localization:
Cell projection, axon. Cytoplasmic vesicle, secretory vesicle lumen. Secreted.
Sequence:
MKNTHVDLICVFLSIFIGIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHARTRRSAGHHAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMSPSDPLYGYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASGDGGEDDDCNCDGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGRNPETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQKAHKRSH