lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSTNNIIEGDEDTKTTITNESNTDNNNNNNDDNKNNTENTTSPTNNNNTNDNDNNSDNNNNKNNNNNNSQVTEEQQVTLEDSGSEDDINFEEHELSDSAEEDEDEMEDDDEDADGRQNQNPNSAGGKRRGRPSKVQQSTNTHLSQTTPESPTIFTPDGKVPKRISTSTNNTPNTQSALKTNKRPRLTSDEEKDLMLSEESDGGVGEDDDSIMSTNDKPQDENQSNQNQNNNNNNNNNTTTTTTTTNNSNNNNQNLNQNNNNNNNNNNINNNNNNNNSNNDNNNNNNRPARGRPKTNGSRSEERKRIQLQQYIQATQGSSTTTSDPNNQNNQINQINQNNQNNQNNQNNQNNSLGEEEFGEEFEEEEEDMGQPKKKTKYKTSKKSVPNHLDIRPCWFVGCVKADRSLKILRPCLIPTCKTHAIKSEVRISEALRRGDFVNDESSGVKDKVCGICGDKKDLHHCGNNGCAFGFCNDCVEIAAMKHNNHPNGNKWICWVCQFVRTKAKEKERTRWVKEQLNPGLTSISRKFRRGPELDMAQAQFLQQQQQQQTSPNEKRSSQFNSNNSNNNNNNNSNNNNNNSGFDPSGSPNNQQNQKRLRKKINASSDIYETRKYTKKRNDEDSAPPSPTSIIGNSVMVGSSGAAGGGIIKNTTVVVEQQGYSATPPSPNTLMVQQQQQLQQTHQQARLSQQQAQLQQLKALQQQHQHQQQNNGNFNNLIESVLSPNREPLNPIDNFVDQTFTAVKFFSTLSQNPPDEIKERIDNFVDLMMRIKTVRWASDYGLVWRMIEELSNLIKRNLLSSQSVVEMYSELKSLEEGALENMTTNARNVPLERAITMVFENHETAGLIGKECCSTRNALIYSIEVALRAIADYQHDLEDNLMEESLRSNKVSTEIEQIEHQIKANLDEIHKFKYQEVELLDSLSKVRGAIAAHESIRDTLQKKSSELKVDMLLIKNGISDKEKETKSQQATLENEIYALKLLITMVESIYWIHDYFYESRVGECEKLINNKLSQLQNKLETQIPHPPNALDNAIPNTTTTVMGEDGQPVIVPTTVDIKNKFKTIAIYHKICMQHKVPNFHLEKPDRIQVAVSCINEFASNPLVDIFDNPPEVDMRYVMAVHDANYIKKLETSLPPENSEFETHLESDKSGAMVTVASHKDFEGDDDNIYDTFVSHRSIKAALRASGSVCAAVDSVSRSGYTRAFCAIRPPGHHAGRYGRTSDAPSQGYCLINNVAIGAKYASLTAGYSRIAVVDFDVHHGNGTQEILSGDDNFLFISIHVCDEKRYFYPGTGQDVGDIDEVSGQFDGNILNIGLKRNTGSAVFLQQWMNKIIPRLEAYKPQLIFLSAGFDGHKDDPTNGLKLNEEDYFVITKMIKTVAFKYCKGRIISVLEGGYGIEKTNSLQRCVNSHLKALIEDTDEEIHLANISYGHFSETQETAIPKFNINNFISNPNKRGKKNNLNTINFINNNMNNINNNITNSLSNKQLERQKQLQQQQQQAQQAQQQQSPQQSQTIENTSITTTTTTTSTTTTLSTSDSESNNNINNNNNDYNNNNNNNSNNNNNNSNNNQPTNFNSSTSSPILSGNNNNNNNNNNNNNNNNINNNNNNNSNNNNNMNTSNPTNQQSSVIISDDMDDVQTNSNPPNPQYPLSPNSVNRGNNPSNISMSGAQRSAPLIISPKPSNSPNSPSTSNNNGTPQNINNSDN
The following text describes a protein:
Function:
5'-3' exonuclease acting preferentially on double-stranded DNA.
Sequence:
MRSPLVLLDGASMWFRSFFGVPSSITAPDGRPVNAVRGFIDSMAVVITQQRPNRLAVCLDLDWRPQFRVDLIPSYKAHRVAEPEPNGQPDVEEVPDELTPQVDMIMELLDAFGIAMAGAPGFEADDVLGTLATRERRDPVIVVSGDRDLLQVVADDPVPVRVLYLGRGLAKATLFGPAEVAERYGLPAHRAGAAYAELALLRGDPSDGLPGVPGVGEKTAATLLARHGSLDQIMAAADDRKTTMAKGLRTKLLAASAYIKAADRVVRVATDAPVTLSTPTDRFPLVAADPERTAELATRFGVESSIARLQKALDTLPG
The following text describes a protein:
Function:
May negatively regulate the activity of cGMP-dependent protein kinase egl-4 which in turn controls body size.
Sequence:
MLELRRNSSPSSAHPSPQTNCQNSQRGDGLHHHHHEAASGSTCCGGMTVFTGANAAKSSNEPAGSASPTVWRKTSHPPLHFNNNETRNRNLQMQLKNRGTKDDWGASLRYDIEEPTSSGLLELLPDVPIVRKLSRPLVKMDDQDDACSVASNESDRTVLSPLVPMSIFDQFLCLTNNLSALISCIIAEAKKNTEAEDYAVFLHDEDNKQMVLFNNETMLMTGKKFDMGYGIVGKVASTMRTMNIRDVSRCPFFNEEIDEQFSIKARNLIAFPLIDSSCSLIGVIVLYNKENGFSRHDEKYIKRFSYFVANSIAHAILAKQIEEVRTRIHMVEEFKIQGEDAVIEEVDIMRLVNDPLRDWRYFSQNFADFSFPPRSVGENHFHRASMMFFEDLGFSMLYKLNKRKLSYLVLRVSAGYRPVPYHNWSHAFAVTHFCWLTLRTDAIRRALSDMERLSLLIACLCHDIDHRGTTNSFQMQSLQKTPLSVLYSTEGSVLERHHFAQTIKLLQQEECSILENLPAADFRTIVNTIREVILATDISAHLRKQERIKTMISEGYNPMSFDHRYLLMCLVMTASDLSDQAKNFHNAKRIAENIYLEFFAQGDLELQLGVKPLEMMDRTNAYVPTVQIDFLFKIGVPVFQLLASVVPEGRTTSEAIDANHLCWVALDEEVRNNPSATNTLEYLRDENLERRIYDRVRKQDPRAAEIASKRFEPVYANGSVPQTQDILDHRFDGYDKKYQIGCSGGQNQSNGKQQQIRSLQKIRSKTSEDDALLKPMDNGGSVAASSTRRGSRTPRRLWRRARQLISSMSSSCASCSPLPSRRQVSEDSESC
The following text describes a protein:
Function:
Component of the GPI transamidase complex. Involved in transfer of GPI to proteins (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSPCKWLTMFLKGCWGKIANMNHLDSCFPLRYIIGRKKASKLLCTMDSGLKSDSHEVERSNFQLNKPEKSLKRYALLSFYVIILLAIPVWWKTTHYERSSLPFEDMENAPSTVQTHLRFSPTFRILDDKGNNLTKEVQKVLEAEPQIYSYNLKVLEDDPVDYRIVLRESTDLQWFWDENNFIIDTPSKGPSELAILIVNCLWEAFSPQVMEVWSKFTRFSSTVEPSRAETKRTVQFSPQYRVLLSLLVGEGNHEPINWDIENAIQKYFNPLIEQLASLAKLNIETQIQYFVEDAEAYIKDDKFCTKHADLPNLVNNFEKYLSFSPHIREPTIHFVLYVPSPQIQPLWLENEDSNIIPTNSMLLPQWGSITTINFNVTEKKLLHDVDLKDYFRVISRDLLLLLGINDVPVSSLSATLADRLLRQRIAESCIEASDTLQNLAKLVHSMQSMAVPKEIQMYVKDTLLSLDMAYKALSQNNLNEALSYSNNAFSKSQEALFHPSMVTTIYFPDESKYGIYAPLFAPILIPLLISFIKEVKDMLRERKLHRVANVPKPN
The following text describes a protein:
Function:
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
Subcellular Localization:
Cytoplasm.
Domain:
The PRC barrel domain binds ribosomal protein uS19.
Sequence:
MIRTIQDLLNERVAIGKIVNTHGLKGEVKFFPYTNSEEIVKNLSSVVLYNSEKKAFYNLTVESVRRMNKLFLIRFKSIDTIEAAERIKGCEVFIKYEELPKLSEDEYYFYEILDCDVFYESGENVGKVVDIIETGSNDVLVVRKKKKETLIPMTKDCIVEIDKGAKKIIAKEMEWI
The following text describes a protein:
Function:
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
Sequence:
MNKELQPKVVFLMGPTASGKTALALELAEKHNCEIISVDSALIYRGMDIGSAKPSAEELARGPHRLIDIRDPSESYSAADFRADALSEIEQIISMGKTPLLVGGTMMYFKALLEGLSPLPSADEVIRADIQAEADANGWEALHDQLREIDPVSAERIHPNDPQRLSRALEVYRISGKSLTELTMTKSAPLPYNVVQFAIAPRERKVLHELIGQRFRIMLEQGFIDEVAQLKARDDLHLDLPSMRCVGYRQCWQYLDGEFDHDTMVEKAIAATRQLAKRQLTWLRSWPELNWLESGAEGNLVTLMRHCR
The following text describes a protein:
Function:
Represses its own transcription and the expression of nmoA, a nitronate monooxygenase. The nmoA-nmoR intergenic region is the sole direct binding site of NmoR across the P.aeruginosa PAO1 genome. Other genes seem also to be under negative control of NmoR, especially PA1225 and the hemO gene.
Sequence:
MDLSSLEIFRAVAHEASVTRAAQRLQRAQSNVTTRIRQLEEDLGVELFLRDGKRMSLTERGSEFLAYAEQLLALADEARQSMHPAEPGGRLRLGSMESTAASRLPALLASYHKACPRVALEVSTGTSHALFDGVRARRLDCALVAAGPGWAGELDGSGLRGEPLFREELLMILPAEHPPVHDVAEVRLRTLAGFARGCTYRQLAEDSLGTPLTVQEVGSYHAILACVAAGACVGVLPRSVLQLLGTPPLRSLPLAEVDTWLVWREGYATAAFERWRGVLGQAGD
The following text describes a protein:
Function:
Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling (By similarity). Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier (By similarity). Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription (By similarity). Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency (By similarity). Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways (By similarity).
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Localizes to tight junctions in epithelial cells.
Sequence:
MSTTRCQVVGFLLSILGLAGCIVATEMDMWSTQDLYDNPVTAVFQYEGLWRSCVQQSSGFTECRPYLTILGLPAMLQAVRALMIVGIVLSVIGLLVAIFALKCIRMGNMDDSAKAKMTLTSGIMFIIAGLCAIAGVSVFANMLVTNFWMSTASMFTSMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVLMCIACRGLAPEETNYKAVSYHASGHNVAYRPGGFKASSGFESNTRNKKIYDGGARTEDEGQSPPSKYDYV
The following text describes a protein:
Function:
Plays a role in type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine. Substrates include proteins required for biogenesis of the type II general secretory apparatus.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLTPAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVFISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVIAAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPLPFAPAIAAGSILAYLYGDSIISFYIKMALG
The following text describes a protein:
Function:
Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated. Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20); Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription.
Subcellular Localization:
Nucleus.
Domain:
The YEATS domain specifically recognizes and binds acylated histones, with a preference for histones that are crotonylated.
Sequence:
MDNQCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDETTVRKLQSCLEAVAT
The following text describes a protein:
Function:
Regulates DNA damage response (DDR) synergistically with ATM. Together with ATM, involved in the splicing of the ND2/NAD2 mRNA. Required for the accumulation of mitochondrial respiratory chain complex I. Negative regulator of plant responses to abscisic acid (ABA). May have a pivotal role in vegetative growth and the phase transition from vegetative to reproductive growth.
Subcellular Localization:
Mitochondrion.
Sequence:
MAALSHRLRSFTRRFSSTRTTQRSGGGANTKVPILYTSPDIDSDPVTLQLFSWGRGASGQLGGGIEEIRMYPSPVANLLFRSDQSFSLAQTPGRIDADSSSFRIGISCGLFHSGLTIDGDLWIWGKGDGGRLGFGQENSVFVPNLNPLFEEHSIRCIALGGLHSVALTHQGDVFTWGYGGFGALGHKVYTRELVPRRVDDSWDCKISAIATSGTHTAAITESGELYMWGREEGDGRLGLGPGRGPNEGGGLSVPSKVKALTVPVASVSCGGFFTMALTKEGQLWNWGANSNYELGRGDNLGGWEPMPVPSLEGVRITQIACGGYHSLALTEEGKVLSWGHGGHGQLGSSSLRNQKVPTEIEALADKKIVFIASGGSSSAAITDGGELWMWGNAKDFQLGVPGLPEIQTTPVEVNFLTEEDECQPHKVISISIGASHALCLVSRSP
The following text describes a protein:
Function:
Required for sporulation. Plays an important role in cortex and coat formation.
Subcellular Localization:
Forespore outer membrane; Multi-pass membrane protein.
Sequence:
MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIHDILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLVVSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFPIRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR
The following text describes a protein:
Function:
Involved in reticulocyte adhesion. Specifically binds to human reticulocyte cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MEKNVLWVIFYNFLVILLASCNDSNRSKSNSLKSESKSLPTYANLMRNGQDKYNNAKTEDNIGNQINNDNNHNGYNDNRINSEYPKTSHLQHSPSLVHLNDHKFTTKPSRHSYVQRNSIYKRNTNNNMENTNNELHVVPNFFIQEKKAAPQKPSVQNTPTATQIVYNNLDYLNAFDDTNNIISAFKPHHPIIYYFKQLEHFANSYYDLRNKIKDYFALPMKQASDVVEKNVKDCLQNINESRILMTQLENPQNYNDISDKYDEKVKEYKKKIEDMQICLKDSYIKNFKAIMSANLKMNLALNGIYIHWWYLTCSTKTYDDIVKEYAIEINDFDEKKSISFMDNMKKIHKSAIDTLKKMKAELNTSLDSKRTEFIIGEIGHMIEKFNLHLTKIRYASAFIKSIPLQKVESDIYRVELKTLFYVAAKHYADFKFSLEHLKMFENLSKSKEKMLYSTFEKLEGDLLNKINTLMGSEQSTSDLTSIIADSEKIIKSAESLINSSSEEIAKYALDSNEKINEIKKNYDQNILKVREFINKSNGLITSVKGTSQLSESDKQQIETKIEEIKKKKKDILERGKEFINIMNEIKKKKKSNSSNSSTNSKEFTDKLKELETEFEGLNKTVKGYLQEIEDIKVKENEDRSLKNQIEQHLKYTSDNRDNVKTLISKNDEIQKYIEKIEKLINDAPSGKDKFTTEKTNLQNKVKKIIDEFHKEDLQLLLNSLSKFYEEHQKLYNEASTIEKIKDLHQKTKEEYEKLEKMKFSNFGQILDKLNTELDNLKTLEKNIVEEQTNYINKVMSDSLTNLTAEVDNLRSALDGYRADETELKTYKNRINERKEKFLSTLKEQEDDIPDGKNIYEEYNNHKNVMVNKEHKISSDINQCNENIIKAEKNLETFNTLVQTLDAHTGKKDQKVHDLLQKFKTNLEKLNLNELESGFKSLNGSASTTNKQIENIRKNIDTIKSLNFAKNSSESSKLSLENIIKNKADLIKKLDQHTQEIEKHTFIENEEMSPLLSVIKKEKNRVESDMSEELIKQLNTKINAILEYYNKSKDRFNGDDETNLEELDDFKKQCQDAQQEIKKLTTNYNVLDNGINVIIKEQHEKVIILSENHITEKDKKINEKIQQNVNSLNEMKTKLGLLKINEDIKNSRDTTIKSKIQEFEKKVQTIFGSIDVANKKIDAIKKEHDVNKDEFDKEKVKDTSFDEKKKSIEKAYEKMGNTLKELEKMDDEKNIEKEVEEAQIQYKRIFIDHDVNLMNDEVEKSKIVMEKIELYKKEIDEIKQKTNEYKQGDTSNFYYTEQYNSATQSKAKIEQFINIATTKKGTSDTSQDINELESIKEEVHKNLQLVKQESNSMEEMRKQILSMKDLLILNNSETIAKEISNNTQNALGFRENAKTKLNKTDELLQRVAAMIEEAKAHKNNIDIALEDAQIDTEVSKIEQINREIMNKKDEIKSYLSEIKEYKDKCTTEISNSKRGKDKIEFLEKFKPNEESNSNKVNINEINENIRNSEQYLKDIEDAEKQASTKVELFHKHETTISNIFKESEILGVETKSQKKINKAEDIMKEIERHNSEIQTQVKGFQENLNKLNEPHNYDNAEDELNNDKSTNAKVLIETNLESVKHNLSEITNIKQGGEKIYSKAKDIMQKIKATSENTAEKTLEKVKDDQSNYVNYLNQITTERNLIVTEKNRLNGIDSTITNIEGALKESKGNYEIGFLEKLEEIGKNRKLKVDITKKSINSTVGNFSSLFNNFDLNQYDFNKNINDYENKMGEIYNEFEGSLNKISENLRNASENTSDYNSAKTLRLEAQKEKVNLLNKEEEANKYLRDVKKVESFRFIFNMKESLDKINEMIKKEQLTVNEGHGNVKQLVENIKELVDENNLSDILKQATGKNEEIQKITHSTLKNKAKTILGHVDTSAKYVGIKITPELALTELLGDAKLKTAQELKFESKNNVVLETENMSKNTNELDVHKNIQDAYKVALEILAHSDEIDTKQKDSSKLIEMGNQIYLKVVLINQYKNKISSIKSKEEAVSVKIGNVSKKHSELSKITCSDKSYDNIIALEKQTELQNLRNSFTQEKTNTNSDSKLEKIKTDFESLKNALKTLEGEVNALKASSDNHEHVQSKSEPVNPALSEIEKEETDIDSLNTALDELLKKGRTCEVSRYKLIKDTVTKEISDDTELINTIEKNVKAYLAYIKKNYEDTVQDVLTLNEHFNTKQVSNHEPTNFDKSNKSSEELTKAVTDSKTIISKLKGVIIEVNENTEMNTIESSAKEIEALYNELKNKKTSLNEIYQTSNEVKLQEMKSNADKYIDVSKIFNTVLDTQKSNIVTNQHSINNVKDKLKGKLQELIDADSSFTLESIKKFNEIYSHIKTNIGELEQLQQTNKSEHDNVAKHKEKIVHLINRVESLKGDVKNHDDDQYMKKLNASLLNDNIKNTNSINISDEELKKLLKKVEENDQLCKNNNTQNFISDIMKRVEDLNRRFTENLPEKEKLHQIENNYNEISSIFSEINLQDVDEFVAKIHKQIDAEKASVNNVREAEKIRTAIQNVTSYDTEIISRLSEMNNVLERITTRKTKMDQLLKSLSPDNTSLNLNARTHVRKSEDIIKQLNSHIGEITELNTYAHEVMTYLENELNKLLKQLEIERAKLETKTSPSGMKAKEEKVPPKETENRAQDNLASVPQKTLEDNTQQMPENSVQDNLASVPQKTLEDNTHQMPENRVQEDSISAPQEQVEYSTLAVPENDETTEEESEHDDAHDDTHDDTHDDTHDDTHDDTHDDTHDDTHDESQTGRDSTAKEAIGKTRLAGAVIIAMSVLSGFIIIVFKDKDEEEKDHNEHGYNEAFGEHDEYNMHDKEEVIEVCFNEED
The following text describes a protein:
Function:
Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage; Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
Subcellular Localization:
Membrane.
Sequence:
MPVGSYPVGQQGGGGQSCFQKIKMGFFMGCMIGGATGVLLGGFAAFRGGYRGKAFVTQMGKTAAQSGGSFGVFMSVAQGLRC
The following text describes a protein:
Function:
Binds dsRNA and ssRNA and probably participates in the packaging of viral genome. In the dsRNA binding mode, the nucleocapsid protein specifically binds to the vRNA panhandle secondary structure formed at the termini of viral genome. Does not discriminate between viral and nonviral RNAs through ssRNA binding mode. Displays dsDNA endonuclease activity that is sequence non-specific.
Subcellular Localization:
Virion.
Sequence:
MENKIEVNSKDEMNKWFEEFKKGNGLMDTFTNSYSFCENVPNLDKFVFQMASATDDAQKDSIYASALVEATKFCAPIYECAWVSSTGIVKKGLEWFEKNSGTIKSWDENYAELKVDVPKIEQLANYQQAALKWRKDIGFRVNANTAALSNKVLAEYKVPGEIVMSVKEMLSDMIRRRNLILNRGGDENPRGPVSREHVEWCREFVKGKYIMAFNPPWGDINKSGRSGIALVATGLAKLAETEGKGVFDEAKKTVEALNGYLDKHRDEVDKASADSMITNLLKHIAKAQELYKNSSALRAQGAQIDTPFSSFYWLYKAGVTPETFPTVSQFLFELGKQPRGTKKMKKALLSTPMKWGKKLYELFADDSFQQNRIYMHPAVLTAGRISEMGVCFGTIPVANPDDAAQGSGHTKSILNLRTSTETNNPCAKTIVKLFEIQKTGFNIQDMDIVASEHLLHQSLVGKQSPFQNAYNVKGNATSANII
The following text describes a protein:
Function:
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
Sequence:
MDSVRGQGGIQMLLTAEQDAQHIVNSARTAKTARLRQAKNEAEREVQLYRTNMEAEYEKMISDTSGSSGSNVKRLEEETDAKIKNLKESSSKVRSDIVSMLMKYVTTVKT
The following text describes a protein:
Function:
Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLVRLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKKTFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLKQEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIAQGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIASFVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNIDNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESALIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERAVKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES
The following text describes a protein:
Function:
Transcriptional activator. Has a role in the parasite erythrocytic cycle where it directly regulates key genes involved in cell cycle regulation and progression. Binds directly to Myb regulatory elements.
Subcellular Localization:
Nucleus.
Sequence:
MFNNNNEYECLCILEEKLVKHLDVIDKLIENIYDNINNLNEYINKKYNEIKILASKKPTRINWMKCDDKTHMSLFFDKKIGFIPSNEDALKILDSQLMLSNYRKKYEYKKNSWTKKDIDKLFETVDITLKKYACYYLIDQNLSCDEKINKKKMIEQSEPKQIFSQIKLFFDKYNKENTHNKGNEDNVNKNINDNISKNNITHTQNCYEPIEKEQDNSNNIFSYTKNDKNIEHNFLYFSETFWNEVSEKLSNNQNAKECQKMWLYYGCFEDDKQKKWTKDEVDKLLCLSKKYEQRNWKCIARELNTNRSPLSCFEQYIKINKLYENKEKVKLERIAFNVLEDIQLQILVSIIGDKNWAEVKKHMESLNSNTSRIKKRKTNLNFFEKEKQKKFLNDEISYKRRYLRLISATNNMEQ
The following text describes a protein:
Function:
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
Sequence:
MEILGGPHFAVAGAGESHGPAVTTIIHGSPPGFRIRRCDVQPFLDRRRPGGNKHGTPRNEKDKVVFLAGLYRDDTDALLTGSKLTVDVDDQSFETEGYEDGFTTGEPIAAIVLSTSKKSGDYTQFSGPTGEVRPGHTDLVKFHQSKGFVDVRGGGRSSYRSTITDVIGGSVARIILRECFGTRFVSSICQVGSLKSKQSLADTLTIDNIDEIETSLGEAEIASIDHEFANEAGELIKETRKRGNSLGAAVEVVAVGVPPLLGQPLYQSLKVRLMGALGGLNAVQSCEIGSGVDVIPRTGSENNDPIRSSGYQSNTHGGLLGGITTGSPLVARVGFKPTSTINLPQDSVNKRLDEIEFELAKGRHDPCVGVRAGVTLESRMAIELLNSVLAYQATAHCGDSIKLF
The following text describes a protein:
Function:
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSAPHWWDQLRAGSSEVDWCEDNYTIVPAIAEFYNTISNILFFVLPPICMCLFRQYATCFNSGIYLIWTLLVVVGIGSVYFHATLSFLGQMLDELAILWVLMCALAMWFPRRYLPKIFRNDRGRFKAVVCVLSAVTTCLAFVKPAINNISLMTLGVPCTALLIAELKRCDNVRVFKLGLFSGLWWTLALFCWISDRAFCELLSSFHFPYLHCVWHILICLAAYLGCVCFAYFDAASEIPEQGPVIKFWPSEKWAFIGVPYVSLLCAKKSPIKIT
The following text describes a protein:
Function:
Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
Subcellular Localization:
Nucleus.
Sequence:
MEGHAEMEMLRTLKGPSTGEVSVHLVARDSPGSGSHLPTAAFIIPASSAALGLPSSALDVSCFPREPIHVGTPERAAGSVPVTATVLPQLSTGPAASPSASTVRLLEWTEAAAPPSGSGLRFRISEYAPPNMVGAEQPPSPELRREGVAEYEDGEAPAGGGGADPQQPADLPQDPPEGPPQDPPEDDGTCPCQACGPQQGAGPDPSSSNDGCPQRFQERSVIVENSSGQNNCTSASELLKPVKKRKHREYQSPSENESEPEAMEKQEEGKDPEGQPTTNTLESDEWNSSQPASEEKKPGWSWESYLEEQKAIAAPISLFQDYQTVTHNKNGFRLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWINANSPDIHPAGWFEKTGHKLQPKGYKEEEFSWSQYLRSTRAQAAPKHLFVSQSHSPPPLGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDSSSPYIHPVGWCQKQGKPLTPPQDYPDPDSFCWEKYLEETGASAVPAWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKLHFDGWSHTYDFWIDADHPDIHPAGWCSKTGHPLQPPLQSREPSAASPTGCPPLSYRSLPHTRTSKYSFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAERNQSRLKAELSDTEASARKRNLSGFSLRKKPRHHGRIGRPPKYRKIPQEGFPTLTADVTHQSLFMSALSAHPDRSLSVCWEQHCKLLPGVAGISASAVAKWTIDEVFGFVQTLTGCEDQARLFKDEMIDGEAFLLLTQADIVKIMSVKLGPALKIYNAILMFKNADDTLK
The following text describes a protein:
Function:
Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
VVFLAIWKIALTNLTSIKSFFASNSINQQQQRILSPSSIELFIVWLPLWAVLLLGIYALISVLYRVVTFGDCPDAAVELSGQIEEAKSRLKER
The following text describes a protein:
Function:
Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix.
Subcellular Localization:
Photoreceptor outer segment membrane; Single-pass type I membrane protein. Photoreceptor inner segment membrane; Single-pass type I membrane protein. Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix.
Sequence:
MFAFLWKISLCLLVLGVITGDPQAVAAEEKQAKDASPTPQLGVWQFASPSLPPELRKLHGIVEAEQVNRHLLRRRKRSILFPSGVKICPDESVEQAIANHLKYFRLRVCQETVWEVFKTFWDRLPEREEYHTWMSLCEEGTMSIFEMGMNFSQSEEHRSLIVKKLSYTKEAMAGSCTDWSCGGTPTPASDADATTLRDAAANVPPPHEVSIESPPGGTSHEIEDADTTINNEIKKEDEIPVRPVTEQMIEFSIVIAGEKYSEELSDPDTAKYQLLSEQFVSQIQNVFEGLPGYKNIHVLEFSSPEEDSGVEVHYAVTFDGEAISNATWDLINLHSNKVEDNSFMGIEDNPTVVYTISDFQDYIAEILQKNALLENTSLTLDPNSLQLINVKEILHPTQEDPSWITEHPTVLEHVEFDDNTFSAERPSADESTVSNTLPFDFTKPDSTLDSEESDDNEIRPRPESLDSEVSLIPEAPLSSEADVTSLPDGLXLADWNQTPALVTAPVIEHDSLDSLEWLSAPDSSDEFEDTGLSDDFLLPSSPSSHLVPEEPPSTDDYTAPLLSAPTVASSSVIETDTKRTVTAEKEVVTQGSPADSSSADSLLHEXVEESPFPLEVHPVEGEXDIYLGDRMIFDDGSGSAFDGSGKGMEPSIWPWDVATLEPVFYPGPDSWLDDDNDSLPFRTEDIPEGLILDYILNSGNKLDDDPSKDENEGVASIKENFLDESEIFVFPETTTQQVPLLQTGEPSSVETSTQMETLSMDDDSFVKPSFVLEPPEDYSFADLPTGEDLFLPHSTGVSVEDTLLTSTVTLGXEDSLLTSTVAFSVEQPEESSVGQEIISEAXEHQNEDRPTVEELFTAGQSNVGEAATVGYLDKSSLETVLTAEPFEVSTDTSTEEQQSLDSSLADRDTGLAIRKPADVWPTDRVLEKTLDQTVQSAVPTAAQVSTAVPSLIHQATALEGFAGQDGTEHDTHVSMSISTILNSYVTITADTVELPSHLPPMTTTVSSSVVTLAKVGDETTRVLDVSVDLDHVSMVSFSPEPSEEAKSMTDSHMELTTHAHSTEMAGVAWPTHEIHNSTPVPSRALVVFFSLRVTNMMFSEDLFNKNSPEYKALEQRFLELLVPYLQSNLTGFQNLEILNFRNGSIVVNSRMKFAKPVPRNVTNAVYMILEDFCNTAYHTMNLAIDKYSLDVESGEQADPCKFQACNEFSECLVNRWSGEAECVCNPGYLSIDGLPCNSICDLQPNFCLNDGKCDISPGQGAICRCRVGENWWYRGEHCEEYVSEPLVVGIAIASVAGFLLVASAVIFFLARTLRDQYTKSDTEDSQGQGDSLSSIENAVKYNPMYESDTTGYSHYYRRYPQLTSYSSTSAETSTDYSSEEIRHIYENSELTKEEIQDRIRIIELYAKDRQFAEFVRQHQMKLL