lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Has a role in the biogenesis of eye pigment granules. Eye pigment granules are specialized forms of late endosomes or lysosomes. Biogenesis of pigment granules in the eye requires molecular components required for protein delivery to lysosomes.
Sequence:
MDATNKQYALRDRAELSAFVNQPFRNNSRIKFTCFDCSPKYFVFGANSGSLYLYDRITTSFLAIFPSQLGTIGKVSISHNEKQIAIGNQTGSIGVLLELEPPHVKEILSTELAPSTDGEGQPIDLGGPAFVTSFCWTEDDRELYCGDSRGIVSLIQFSLFMGRNILNISLHPVLLLENRIVQIDRYKDLLLVSTLSKCVLCNTAREEFKQIGNRPRDGQYGASFVIAHPNTIASATTTTTTPSPPLMIVDEEDVRIFCSRPGSRLWEADLEGNVIRTHQFKQAAAAAAAVAASRRRRSQQQQQQLQCLQESELATAPTEAPDGTLMVVPFQVLYSIRRQLLLVHDRCQLLIIDPLHSKIVLRTDEFTDITHVAVVDEWIYLLTGENRVFQVRVEIQGDEDPFPTPGMVDEPCLESRKQKQGVYILDSMLNNNNNNNGKQMNGKESPLLLSTEATIKEALVSVVRGKYGRNIKQMFMGYEQQQQQRTPSGAPERPKTLNLTKIYEPSRSNAFANGNGHALLAEFGIEAEVEDLECDDMMEELVQTRTGQALLGTAMPNGAGTGKQQPGKKKFSTSLLDGYETSEDDATVRNLYLIFRSSIISNLNFADRYAKIFDEYDTETIVRLLRKLETLMEENEEPNARLKCMRIYFHYLKPELLWEIDADSRQFIKDGFIVCNTTDGADRARLERLAHCAACGYYLEATASCHYREIGTSLLQYYWSRKEYDECFAMVKRVPYLWRTITRYYIQDRREDKVVQCVWNLADSELLERAAGELPFELDHWRQLFELAIAYHQRHEMICLSCDKPTGGRLEDNQRDNRSAAKANGGGDHRAAGSTEAESQFRQWNYLLGVALAHIRSPTELLCLVRRYADNIPRGAIAPSFYIRCLLLEAK
The following text describes a protein:
Function:
GTPase-activating protein for Rho1. Involved in the F-actin patch localization, cell morphogenesis, regulation of septation, and cell wall synthesis.
Subcellular Localization:
Cell tip. Nucleus. Note=Cell poles and cell division site.
Sequence:
MSQRDAKKDGLLYTTNGVSPTPPKRIPVPSRQNKIEENSTTKNFPHSRHTSTVAGTEGGSSLSRRHTSAESRKALPNQQQLAQSGLLNKEEQQSLKRSDTSVFPKAVRKVSSSKICASCGQVISGQYVRALGNIYHLECFRCHDCNSLVASKFFPIDDPTLNKQVPLCETDYFRRLDLLCASCGMALRGYYITALNKKFHIEHFTCSLCYTVFGPNDSYYEYEGKVYCHYHYSTLFAARCCGCDGPILRQFVEVYRNGVSQNWHVPCHMIYKFWNVKLCQKTSIETSKKKDSELSQSQLRKREKHLEQKIFHIWHALSYFEEYTASCISDMLLLVSNGEFTKSVICAQKFIRYIEILFKGIDSLETILSSFHAKSMPYVREAKLLCKKLVSIFALLAKCHNSDIRDVAIVQDFLSLFTGLAHYLKLLIRISLTGGLRLEQDHACKHALPQFLQTVEEARFVDQEGYDSSSFDMPLNLANASSDLCYVCHSALEEDCVLLGEIRCHIGCLSCTKCKYNNRENYDWARWNNQTKQIECYLCYTESSNVSNDEPHPSFEYVSRLSQYIYLLRIALVRLYTILMENNDSSQRKPLSVDPKQENVSSTVETAKQAETTASSDSFRKYANTLNDLRHLKSSRNRKATSNETQSSSNSTETSKLSKNVSESGKDKSPHWHSHGGSITGKSIVEQASSPLERRMDAFDENRAFTLDDIPKVISEQRNREHRPNAFRHMPSYTDPSYRKNSGAIYDKNDGTQKGLTPKSEDAPIRYLSDLSNLELLFTKHVAVLILHPLVRDYYSLDELMEMSDLRKGGFWEKFGKAFKGKDAEKKNVKKKGTFGVPLEILVERNNAQSTVGTGVGVKHIPAFIGNTLAAMKRKDMSVVGVFRKNGNIRRLKELSDMLDVSPDSIDYEQETPIQLAALLKKFLRELPDPLLTFKLFGLFITSSKLESEEERMRVLHLTICLLPKGHRDTMEVIFGFLYWVASFSHIDDEVGSKMDIHNLATVITPNILYSKSNDPVDESFLAIEAVHLLIENFEKFCEVPREISLLLDDPTLFYNNAAWTSKELYKRCEEIISQMSLDERNTPKHTASTKRKRQPIRRVTTNLTSDVPSGSEVADTNSLSSTTKDEASPNSDAQPKPQVKPQHAVIRDS
The following text describes a protein:
Function:
Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVAIDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQVVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSLFKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVAVISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDLTKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPVDKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECPTVERLKMLADERLYKSKKNGRAQISWQ
The following text describes a protein:
Function:
RNA-dependent helicase. Plays an important role in the assembly of the mitochondrial large ribosomal subunit. Required for optimal function of the zinc-finger antiviral protein ZC3HAV1. Associates with mitochondrial DNA. Involved in nervous system development and differentiation through its involvement in the up-regulation of a number of genes which are required for neurogenesis, including GSC, NCAM1, neurogenin, and NEUROD.
Subcellular Localization:
Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid.
Sequence:
MFSLDSFRKDRAQHRQRQCKLPPPRLPPMCVNPAPGGTISRASRDLLKEFPQPKNLLNSVIGRALGISHAKDKLVYVHTNGPKKKKVTLHIKWPKSVEVEGYGSKKIDAERQAAAAACQLFKGWGLLGPRNELFDAAKYRVLADRFGSPADSWWRPEPTMPPTSWRQLNPESIRPGGPGGLSRSLGREEEEDEEEELEEGTIDVTDFLSMTQQDSHAPLRDSRGSSFEMTDDDSAIRALTQFPLPKNLLAKVIQIATSSSTAKNLMQFHTVGTKTKLSTLTLLWPCPMTFVAKGRRKAEAENKAAALACKKLKSLGLVDRNNEPLTHAMYNLASLRELGETQRRPCTIQVPEPILRKIETFLNHYPVENSWIAPELRLQSDDILPLGKDSGPLSDPITGKPYVPLLEAEEVRLSQSLLELWRRRGPVWQEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDILAKLGKHQYLHRHRHHESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQRLQEALGMHESKYLILPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAETSITINDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQAKIHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSSLQNRAEVDKVKALLSHDSGSDHLAFVRAVAGWEEVLRWQDRSSRENYLEENLLYAPSLRFIHGLIKQFSENIYEAFLVGKPSDCTLASAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSVTYRTKSGNILLHKSTINREATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAVLLLTDGDVHIRDDGRRATISLSDSDLLRLEGDSRTVRLLKELRRALGRMVERSLRSELAALPPSVQEEHGQLLALLAELLRGPCGSFDVRKTADD
The following text describes a protein:
Function:
Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In the presence of host integration host factor (mIHF) forms a specific intasome complex with attP. The intasome subsequently binds attB and forms integration products. mIHF probably stabilizes a sharp bend in the DNA during integration.
Sequence:
MARRGWGSLKTQRSGRIQASYVNPQDGVRYYALQTYDNKMDAEAWLAGEKRLIEMETWTPPQDRAKKAAASAITLEEYTRKWLVERDLADGTRDLYSGHAERRIYPVLGEVAVTEMTPALVRAWWAGMGRKHPTARRHAYNVLRAVMNTAVEDKLIAENPCRIEQKAADERDVEALTPEELDIVAAEIFEHYRIAAYILAWTSLRFGELIELRRKDIVDDGMTMKLRVRRGASRVGNKIVVGNAKTVRSKRPVTVPPHVAEMIRAHMKDRTKMNKGPEAFLVTTTQGNRLSKSAFTKSLKRGYAKIGRPELRIHDLRAVGATFAAQAGATTKELMARLGHTTPRMAMKYQMASEARDEAIAEAMSKLAKTS
The following text describes a protein:
Function:
Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Also acts on 1,3-diaminopropane and 1,5-diaminopentane.
Subcellular Localization:
Cytoplasm.
Sequence:
MAKFVIRPATAADCSDILRLIKVAEARAPPRAGGGSVSGRVRVSRRFPLLPQPRLAAPLWAGLWEEIAPRLPAAPPALSRGAAGPGPHLVSSFSPCLVCASPQELAKYEYMEEQVMLTEKDLLEDGFGEHPFYHCLVAEVPKEHQTPEGHSIVGFAMYYFTYDPWIGKLLYLEDFFVMSDYRGFGIGSEILKNLSQVAMKCRCRSMHFLVAEWNEPSINFYKRRGASDLSSEEGWRLFKIDKEYLLKMAAEE
The following text describes a protein:
Function:
Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity).
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein.
Sequence:
MPLPWISVIWFAYLIVIFVLIVVASVFIHVYQTPRDRSSFVTFICVFSIAALLATVMLLPVDVALVSSTISSALGQREEWATQEEVDKITYSLTIIYYSLYFLDALLCFVGIPFAYFWHEEYDEVAFEAGDQTACKRFWAATKYTLTFIAVVIALVLVGFFAPMMESQPGHDLGYWRGYLIENQGEHAFTFLLGFVTIIGSCLYAFYTPSGLAMLPALFLRKSSSFATQTLGGSTAMELNFNRERQRQLEGRCGGNSALLSAKDRRELDTLVREERTLIRRQRLIEGRQEEDQSWPVTVYSKLKTILRPFRLLGGFCLFLVGLSTWISLLMTVVDKLINSPCKHHCGYVLSRTNFNPISWIFIQSSRAFPTDYIIFALIVFFFFWGSVVGVVAVGIRFLWIRIFQIRKGHTSPQAMLLATAVLTLITLGLNYSIVMMLVPGYATFGPQTFCDLAPTSSEEQSDCSNHRHLVKPCSEKADSTAADKTCTPSVASTILNRVALNFPLFGALLLWAHFLFLAGGGRRRGRGRESVSKHQKKRQSYMRGCPIASREPATSNYERLFKEGFFIFKRR
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MGGHHGEPYTVPHASTYKVESVPQLVEVKEALGRQGLKDPWLRNEVWRYEPKAFGTHRSRLNTFLFRGLGVGFCAFLATVAVEYALGIGKGQGGHGHGHGHEEHGDKGHH
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MDAKLRYKAKKIKIVFFDIDDTLRNSKTGFIPTTIPTVFKQLREKGILTGIASGRGIFGVVPEIRDLKPDFFVTLNGAYIEDKKGQVIYQHQIEKSYVEEYISWAKQEGIEYGLVGSHDAKLSTRTDMMSEAINPIYPDLDVDPDFHEKEDIYQMWTFEDKGDDLHLPDSLSDKLRMVRWHQHSSDIVPISGSKATGVEKVVEHLGLKPEKVMVFGDGLNDLELFDYAGISVAMGISHDKIKEKADYITKTLEEDGIFDALEVFGMVEKELHFPQVDIETVEGPLATIKTNHGDLRIKLFPEHAPKTVANFVSLSKDGYYDGVIFHRIIKDFMIQGGDPTGTGMGGESIYGESFEDEFSEELYNIRGALSMANAGPNTNGSQFFIVQNQHLPYSKKEITRGGWPEPIAEIYANQGGTPHLDRRHTVFGQLADEASYAVLDVIAAVETGAMDKPVEDVVIETIEIED
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEVYLSEFINWKLYEFKKINELGTSTFRYYFKGKIVNLKNKRVSSNEVCYMFKLMDDTGIVELNYSLSKYSPKFEMLRQLQLGISVFVYSDVVCRVSGIRAWKLQIHSKNLESKIEATISEPEQIPCPGFGSDNIVPLSLVNDFKDGAFVNVLVAIQWKEEFEIFNNETKKSLPKQTIHVHDISGSAMIVLIGESQVKSALSWNNETILLIHNAIAYRTNTGMLELSIKDAIIQTLQSFDGKVLKLLNFSIKRKELIKINAYRLSTLEALEKIASQSGEAFGQVGVLIMQSKIKDLTKEGGLVYGNDLTGLRFADLISIIVDETGSVKNPKFSQKLLEEITNIAPTELSVLNEEQAMHLENVFLYRHYRVCVGFLNKQIYVFSSDEPLKSYI
The following text describes a protein:
Function:
May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
Subcellular Localization:
Membrane; Single-pass type III membrane protein.
Sequence:
MTGLSMDSGGSPKGDVDPFYYDYETVRNGGLIFAGLAFIVGLLILLSRRFRCGGNKKRRQITEDEP
The following text describes a protein:
Function:
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
Sequence:
MSSAPRKLTKAMREDDDGGNSGSRASMRAPSTSSVKHQSLGSELLDDEEFKAKTFQDLGLCQELCAACADAGWQHPTRIQASTITVFAEGRDLIGVAQTGSGKTGAYALPLVNWLLAQRKTPYLSVLVMVPTRELAQQVTAQFVLLGRSVGLRVATLVGGADMVEQACELSKRPHVVVGTPGRVKDHLSNTKGFKLVKLHALVLDEADKMLDMNYEKEIDAILEQLPQNRRTMLFSATLSTKIDRLQKASLRDPVLLQVHRKNTTVDTLKQYYIFAPFAQMLSYLHLFLTKETGNHILIFCRSAALVHKITLTLRILGHRALPLMGRMDQSNRNIALTKFKEGKVRMLICTDVAQRGLDIPHTDVVVNFSLPDHVEDYIHRVGRTARAGAEGKAVNLISQYDIVLLQKIEQQTGVKCVEYPSLPESEVQLVLQRVEDAEQEAIREIREDAEERSLEKESRQLTTARKGKRDRGDADMGYDDAKHGTSDFATLRMRREHESIFEMTKKEQHKSLWAKRREAKRQAKSR
The following text describes a protein:
Function:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
Subcellular Localization:
Early endosome. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane.
Sequence:
MAKRCTQYPPYPWGCSKTTDRIMKGRSSYLIYSFGGLLSLWILVVSSTNQCTVRYNVADCSHLKLTHIPDDLPSNITVLNLTHNQLRGLPPANFTRYSQLALLDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISDQTFAFCTNLTELHLMSNSIRKIKSNPFKNQKSLIKLDLSRNGLSSTKLGTGVQLENLQELLLAKNKIFALRSEELDFLGNSSLQKLDLSSNPLKEFSPGCFHAIGKLFVLLLNNAQLNLNLTEKLCWELSNTSIQNLSLANNQLLATSNSTFSGLKQTNLTSLDLSYNSLRYVGNDAFSWLPHLKYLSLEYNNIQSLTPHSFRGLSNLRYLSLKRAFTKQSVALASHPNIDDFSFQWLKCLEHLNMDDNTIPGIKSNTFTGLVSLKYLSLSKTFTGLQTLTNETFVSLTHSPLLTLNLTKNHISKIASGTFSWLGQLRILDLGLNEIEQELTGQEWRGLGNIFEIYLSYNKYLQLTSKSFTLVPSLQRLMLRRVALKSVDISPSPFRPLYNLTILDLSNNNIANLNEDLLEGLENLEILDFQHNNLARLWKHANPGGPVNFLKGLSHLHILNLESNGLDEIPVKVFKNLFELKSINLGLNNLNTLLPSIFDDQTSLRSLNLQKNLITSVEKSVFGPAFHNLNSLDMSFNPFDCTCESIAWFVTWLNQTHTNIPELSTHYLCNTPQRYHGLPVKLFDTSSCKDSAPFQLLFIINTSTLLTFILAVLLIHFEGWRISFYWNVSVHRILGFKEIDAQGEQFEYTAYIIHAQKDRDWVWEHFSPMEEQDQSLKFCLEERDFEAGVLGLEAIVNSIKRSRKIIFVITHHLLKDPLCRRFKVHHAVQQAIEQNLDSIILIFLQNIPDYKLNHALCLRRGMFKSHCILNWPIQKERINAFHHKLQVALGSRNSAH
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
Sequence:
MELYLPRPLCTVVNCKDLEHLDVDTALTEMKKEQEVFRLLPDVYAYRYDFKRLSPSVINDYEYCPRLLWTQYKLGLKLFSIDSAVAIVKGRLLHERYERAVSIFDNVIAEYKIEIGDLVGVVDIVMRKGNEYIPVEIKTGLASREAHRRQLQIYIHMLKARYGYLVYRNRVEKVERDSKAVEMLYKIKSVLQMDKPPNVNCKSCPFKYICKNVL
The following text describes a protein:
Function:
Prevent apoptosis of host cell by inhibiting caspase-3/CASP3 activation to promote the viral replication. Also induces the activation of host NF-kappaB.
Subcellular Localization:
Host cytoplasm. Virion. Note=Probably accumulates in the perinuclear cytoplasmic viral factories. Found in association with viral nucleoid.
Sequence:
MFPKINTIDPYISLRLFEVKPKYVGYSSIDARNQSFAIHGIKNYEKFSNAGFFYTSPTEITCYCCGMKFCNWLYEKHPLQVHGFWSRNCGFMRATLGIIGLKKMIDSYNDYYNNEVFVKHKNRVYTHKRLEDMGFSKPFMRFILANAFIPPYRKYIHKIILNERYFTFKFAAHLLSFHKVNLDNQTTYCMTCGIEPIKKDENFCNACKTLNYKHYKTLNFSVKL
The following text describes a protein:
Function:
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Sequence:
MARYLGIVSYDGSYFKGWAIQPNLATIQGLLEQSFSLIIGRKIKVIGSGRTDKGVHAINQTFHVDINGEINLNLLIRKINQLIKPHCIVKTLVLVNDSFHARFQVKTKVYEYLINCGNLNPLQFNYVWQLNQQLDLEKLKADATLFLGKKNFLSFSSSIHTDSIRTISKITIQKETNQLVRLTFFGSGFLRSQVRMIVACLVNLNTNKMALETVAKLFEHPKKGSCVVKAPSCGLYLKTVVYEK
The following text describes a protein:
Function:
Threonine-protein kinase that phosphorylates histone H3 in vitro at 'Thr-3' (H3T3ph) and 'Thr-11' (H3T11ph), but not at 'Ser-10' (H3S10ph) or 'Ser-28' (H3S28ph). Plays a role in mitotic cell division during plant growth. Threonine-protein kinase that phosphorylates histone H3 in vitro at 'Thr-3' (H3T3ph), but not at 'Thr-11' (H3T11ph), 'Ser-10' (H3S10ph) or 'Ser-28' (H3S28ph). Involved in histone H3 phosphorylation in mitotic cells. Contributes to organ and plant development, as well as embryonic patterning.
Miscellaneous:
MISCELLANEOUS: Over-expression of an inactive kinase mutant decreases the size of the root meristem and delays root growth.
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Chromosome. Cytoplasm, cytoskeleton, phragmoplast. Note=During interphase, localized in the cytoplasm and at the nuclear periphery. During prometaphase and metaphase, localized on chromosomes, and around the cell plate during cytokinesis.
Sequence:
MGQRVDLWSEVIKSEEEDGDIPKIEAVFQRRKKPDKSSEAVNFGWLVKGARTSSVNGPKRDSWARSLSTRGRESIAVRAYVNNQPQKKAAGRKKPPIPKGKVVKAPDFQKEKEYFRDIDAFELLEESPSPNKSSTWTMGEQVVPEMPHLSTRLEKWLISKKLNHTCGPSSTLSKILENSAIHQESVCDNDAFDSLSLKTPDKSSAGNTSVFRLIPSCDENLAAEDVPVRKIKMESIDLEDELKRLSLTSDLIPTHQDFDQPILDLLSACGQMRPSNFIEAFSKFCEPESIVKIGEGTYGEAFRAGSSVCKIVPIDGDFRVNGEVQKRADELLEEVILSWTLNQLRECETTAQNLCPTYIKTQDIKLCQGPYDPILIKAWEEWDAKHGSENDHPDFPEKQCYVMFVLEHGGKDLESFVLLNFDEARSLLVQATAGLAVAEAAFEFEHRDLHWGNILLSRNNSDTLPFILEGKQVCIKTFGVQISIIDFTLSRINTGEKILFLDLTSDPYLFKGPKGDKQSETYRKMKAVTEDYWEGSFARTNVLWLIYLVDILLTKKSFERSSKHERELRSLKKRMEKYESAKEAVSDPFFSDMLMDQIS
The following text describes a protein:
Function:
Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.
Subcellular Localization:
Nucleus.
Sequence:
MDDDQQFCLRWNNHQSTLISVFDTLLENGTLVDCTLAAEGKLLKAHKVVLSACSPYFATILSQQYDKHPIFILKDVKFQELRAMMDYMYRGEVNISQDQLAALLKAAESLQIKGLSDNRSSSSSGTAAAGGGVHQKQSDAPAAKTLQPPVPASKASGLTIENKRSLKSELLESDVSGSREGSTSPTSRKRKKVRRRSVDTNNLLIDNHDQHSNSSSHSMHTAGGANVAAAVAAAGAPAANVASSLSSASSTAAAGSNTSANVLSVAAVAAAAVLKKTETVQQAAAETLKLQKQQAAAAAAAAAAQSSDDEERCGPGSVATGTEHDDGNDLSDNEHDGDGGSSVKSGSRHHHLRDGSRRGKTSTSSMGEMMIEPKSEYEDVQDENVEDLTMDDEDLMDELDQAGPSHGGDVSNILPLKTTTGSIAKGNITLASGTVGTAMVGKRVSGGNASSPSGGTISGASLVNTAGGTIVTPVSIQKVDASSSELIVPTVVKSEATSGVRKLSASALAGAPAKTFTHPRIKYSRAKNPYSTPANTGITTSTITMPILTIPTVTPSSASSGSSATIQVQEVAQQLAPPTATVAGTERQLLNFSLSRKLGSAGQQSQQHVTITGAGPPGLTTINASTLQQIPIAAAISGANARGGSVTTRYTVNEYETSGSNTSQSADFPPGMIDDLDYSVIEDIDLSDGVSTNFSNVVAAAAAAAMNVVSSGQQQQQQQQQQQQQQTTTIAGSKMSSDVDNNGSQSDDDDGDMMDEGGDEGSGDLGHDDDGEHITKYNTKMLKLKKDSGPMAGAKLLNASVGDSKYALLANPNIMRNFEYTVNESTGVSDTDDGEVRQYVCRHCGKRYRWKSTLRRHENVECGGKEASHQCPYCSYKAKQRGNLGVHIRKHHSEMPQLESRRRSNKSRHSM
The following text describes a protein:
Function:
Dynein-attachment factor required for cilia motility.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm.
Sequence:
MAHSDRDEIDFAKLEKELSNALEADKKYWRENDAKIRAVGQRVGTYEEFKGIVAASHLRPLDRKEGLITNERITQTWNAAASKNDQDAAEIAASIPSSNEQDWNVKTAVEFERRFLCRLGGERLYQLYKTEVSNLEGLLQVLHECYQPADAQVIYHMLYCITKSDRFSLTIMFFGKQEKACSTELLVKLKDSLSNQDIQSITFNEDDLVKLRKKYGL
The following text describes a protein:
Function:
Inward rectifier potassium channel that forms the pore of ATP-sensitive potassium channels (KATP), regulating potassium permeability as a function of cytoplasmic ATP and ADP concentrations in many different cells. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. In pancreatic cells, it forms KATP channels with ABCC8/SUR1. Can form cardiac and smooth muscle-type KATP channels with ABCC9.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSKGTAEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDRSLLEALTLASARGPLRKRSVPMAKAKPKFSISPDSLS
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAPSQLAQLKAALNTAGLSRKTHSKKDKKAYKKGGARETDRAKKVEKLEEIRKNLNKFDERETRVKHDVGGRNLKGVVGRPSASKQAGLEQRKKTLLPEHQLRDHRGTFRDRRFGENDPSMSIEDRMLERYTRERQRGQGKKGMFNLEDEDEDEPFGELDDGFALGGLTHGGRSVMDLPGDDFVAQGLADEDEDEEENRAGRIDKRVVSKVHFGGFEEAMDEDLPEKKKSKQEVMAEIIAKSKEHKYERQQQREMDAELREELDGDIADLQMLLAENAPTTPAATLFPTTSKLHPDPMPVPGGEVIGDGEYDQIVRSLAFDARAKPKNRTKTEEEIALEEKENLEKAEAKRLRRMRGENVSDGEEEEGSRKKRKADDKKPDADDLEDDYVEDEALLGPGLTREEIETMVLSGSEAGSDDEQDDEDGREEEESFDEDAEEENESDAESAMEDLTENEELSVSESEEVEPVVKRTKGKKTARTEKVKEIPYTFPCPANIEEFEEIVDPLEDSALPTVVQRIRALHHPSLAQGNKEKLQEFLGVLIDYVLILSSRPSPPFSLIQTLVPHLTALVKLNPITAAAHFVEKIKLMQKNLSRGLARGAARPDSKTFPGAPELALLRLVGLFWSTSDYSHPVVVPAVLLMGQYLSQSRVRSLRDLASGLFLCSLLAQYESLSKRILPEAVNFVASSILILLPRRKGAEVNRTYPDLKAPSTSLYLNLPSSVVPSQPLDLGSAITAVGDQDEEEAEQLKGGLLVVACKLVDKFAGLYLDSEAFVELMSPVKQVLEQSRAKKLSSELNMVLTSTLTALSKRLSNTLSTRRPLTLQSHKPIPIASYAPRFEENFAPGKHYDPDTERNASAKLKALYKKERKGAMRELRKDNRFLAGEKAREQGEKDKEYNARMRKAEGSITVERAEEKAMEREKAKEKRRAGRD
The following text describes a protein:
Function:
Plays a role in synthesis, processing and/or stability of 23S rRNA. Required for embryogenesis.
Subcellular Localization:
Plastid, chloroplast stroma, chloroplast nucleoid.
Sequence:
MSLVCSLSCVAPLPQTKQSRPSFLKLETCTLSLSSPAGYPNFTTGIRKHISYLFTEPIKLPRLAKSRILVSQESFTETSTIDMDWEDQEEIEDTGSPWEGSVMYRRNASVTHVEYCTTLERLGLGRLSTDVSKKRASAMGLRVTKDVKDYPDGTPVQVSVDVIRKKKKLRLDGIVRTVITLGCNRCGESTGESIFSNFSLLLTEEPVEEPDVIDLGFTFGNDKEEGEDDDDNDDSWIDWEDKLHFPPEVKEIDISKHIRDLVHLEITITAICDSACKGMCLKCGANLNKRKCDCGREEKDKGYGPLGNLREQMQQKEGLRN
The following text describes a protein:
Function:
Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.
Sequence:
MAMTDTEFHQLADDMFQAIETAIETAIDEQDADVDIDASGNVLQLEFVDGSKIVINKQEPLHEIWVATRFGGYHFGYVEGKWLDGRNGGEFMPFVQDSILRQSGIELSL
The following text describes a protein:
Function:
May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons. Does not appear to play a major role in ciliogenesis.
Subcellular Localization:
Midbody.
Sequence:
MAAPSEELDRVGTSSGLVESALMTLEADNEPDKQLERLQELMGLLREQRHRETASKQVFQDIKQILTKSSHEVELACRETGHLVYLDPHLQLIAECFRCLRNACVQCPGNQDMIRDLDLIGTSMKLMYLFQKLNVIKQESKLTAFRCGLQFLGNAVAGNEASQRILWKDAFPDLFLACLSYPDEKIVTYSCMILFTCLNSERLKDLQSRNLTIALRVVEAYQKQADAEWAFLIISDYLLKIPELVNSLYAKLSHQERVTLLDLMIAKLVGDEPLTSEDIAAFLSHAGFVASKFQEKCKSVLKLASTGHSDDEEALTTIRLLHVLCEMSANCDLLPSLQAFPGLLKTAVETLKMTHLAGRQTLNVFTTSPCVRGDGDISSPVAGFKSYLIRLIGNLCYKDKNNQDKVYQLDGIPLILDSCSIDDNNPFLNQWVVYAIRNLTEQNKRNQELIAKMENHGLADTAMLKKMGLEVEQQDRKLTLRSTRKASGGE
The following text describes a protein:
Function:
Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Primarily detected in the cytoplasm, and at low levels in nucleus. Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (By similarity).
Sequence:
MSIFTPTNQIRLTNVAVVRMKRAGKRFEIACYKNKVVGWRSGVEKDLDEVLQTHSVFVNVSKGQVAKKEDLISAFGTDDQTEICKQILTKGEVQVSDKERHTQLEQMFRDIATIVADKCVNPETKRPYTVILIERAMKDIHYSVKPNKSTKQQALEVIKQLKEKMKIERAHMRLRFILPVNEGKKLKEKLKPLIKVIESEDYGQQLEIVCLIDPGCFREVDELIKKETKGKGSLEVLSLKDVEEGDEKFE
The following text describes a protein:
Function:
May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.
Sequence:
MTVVVVTDTSCRLPADLREQWSIRQVPLHILLDGLDLRDGVDEIPDDIHKRHATTAGATPVELSAAYQRALADSGGDGVVAVHISSALSGTFRAAELTAAELGPAVRVIDSRSAAMGVGFAALAAGRAAAAGDELDTVARAAAAAVSRIHAFVAVARLDNLRRSGRISGAKAWLGTALALKPLLSVDDGKLVLVQRVRTVSNATAVMIDRVCQLVGDRPAALAVHHVADPAAANDVAAALAERLPACEPAMVTAMGPVLALHVGAGAVGVCVDVGASPPA