lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MSNAMYNKMWHQTQEALGALLDKEPQKMIEPQRNQVFIFQTLATFYVKYVQIFRNLENVYDQFVHPQKRILIRKVLDGVMGRILELKNEMVELELTEFHYFDDILQDLKLAPQQLDIPIPKYFLKEKLEVIKGREKILAQILADSGIDTSDMKYPVKSIPFDEAVKLIQIAERARQGRLRALFMKQIYLQEYRAKQSKMLGKKVTDTWAAALRIQKVWRRFHQRKETEKLREEEMIFLGMNPPPLFNEVSATVIQAEKVDRLRNEVQIKHEEDYREALVTIKNDLKLIEGVDIKENLQDQIRHWFIECRNLTGTFPDYPDVEEGGSAIIFSDKTIQQVIEDIIANQEEEEKNKKKKKKKEKQPKKAKKQKKGTKEKNKEEDEKWKMSPSLFLPAMKEGCNAYKEIWMKKDESWNFSQDYDPELIKEEKRKELQSEIRIQVDELMRQELKNLKLAVDRERERPVKAGKKKDKKGKKGKKKEKKAKKDKDLTADRTIESLYKELVEEGLLIQALKVNLSDYIGEYSYLGTTLRQVSIEPMPSLLDVRQLITLYGIWPLGSAAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNGLQMMLHAVFKVARQLQPSVVWIEDTEKTFYKKVPNAEKMNEPKRLKKHLPQILKLLKPDDRILIVGTTRRPFDAELQSFCKVYQKIILVPRPDYASRYVLWKQIIERNGGVLTSALNVSCLAKVTDGFTQGHIVEVVKGVLTDQRIRRQIHKPLTAVEFITAITSMNPVYKEEEESFKNWYAKTPLGKKRALAITGGSTEKAKDKGKRK
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAHRIFPLIKLVTKVGVAGGAVYVAYDQRLLGDSVQGSEVLTKAKAAIPPAVDEWMKYFGWEVRLPSPPKIEFSALETWNTGVQKLTQTLSVAPTRACEYTSQGWQYMKGLAK
The following text describes a protein:
Function:
Involved in the recognition of invading microorganisms. Binds specifically to beta-1,3-glucan and activates the phenoloxidase cascade (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MADALRFVAWSCCLQLLFLLLGVQGYEVPKAKIDVFYPKGFEVSIPDEEGITLFAFHGKLNEEMEGLEAGTWARDIVKAKNGRWTFRDRITALKPGDTLYYWTYVIYNGLGYREDDGSFVVNGYSGNNASPHPPVVPVSTTPWTPPADPDIDIRLGCTTPKTEVNGAPTRCAGQLVFVDEFNAAKLDPNKWKAERRFSGQPDYEFNVYVDDAPETLCLANGHVVLSTNTMKKQFKKGSGESLDLGEKCTGQANTHDCVRNGRTLNDGLPPMVTAQFSSKDFSFKYGRVEVRAKMPRAQWVTPQIWLQPRRPIYGVDDYRSGQLRIAYTRPNGGNLDLYGAAVLFADEPLRSVKNCLKPGTGNNSEDWSDSFHNYTLEWTPRELRWLVDGKEWCVQGSAKGSFSETTAAGKSLPQAQKLEEGTGLAPFDQEFYLTFGLSVGGFNEYQHEIKPWNERAPQAQKAFWKEVKKIRDHWLDEGHMKIDYVKVYSL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MHKSRLQQLETTYTHTSLKNTHESLVTHTQSQSYARIYQKVLFVSAVLPQYYLRNQERKSSEDQEEAELPWIKEQQEEISVSQEEEQLGLKQEDDIVMVTLHEENELIEDFNNQQFQTQSFNDEFDDEEEALQEASTTDGEAEPQSSRSPVHNVERSQASEPQCDPDSDKSSEGNSCDKTSKKKKSKFACKDCGKKYSSISTLTNHRRIHNGEMPYCCEECGKSFHLRSTFRSHVLAHKPAKLFVCDKCGKSFSENCHLTGHMRIHTEATLFCEECGKSFRHGCNLKRHMLTHTGQKPFSCEECDKSFSQSTTLRNHMTIHTGAKPFSCKECDKSFNRRSTLDNHIKTHAGARPFLCKVCGKSFTLKITLTSHTRIHTGEKPFACEECGKSFTHRTSLKKHMNTHLEEMFCDVCSVSFSRRKDFTEHMRRHASAEDVLQMRKSNLLPPDAEQKIWTSGYTKYCQKLETNIFITSIFTQI
The following text describes a protein:
Function:
Involved in glycoprotein quality control as it is important for the targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations it further trims the carbohydrates to Man(5)GlcNAc(2).
Miscellaneous:
MISCELLANEOUS: Present with 8260 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MKNSVGISIATIVAIIAAIYYVPWYEHFERKSPGAGEMRDRIESMFLESWRDYSKHGWGYDVYGPIEHTSHNMPRGNQPLGWIIVDSVDTLMLMYNSSTLYKSEFEAEIQRSEHWINDVLDFDIDAEVNVFETTIRMLGGLLSAYHLSDVLEVGNKTVYLNKAIDLGDRLALAFLSTQTGIPYSSINLHSGQAVKNHADGGASSTAEFTTLQMEFKYLAYLTGNRTYWELVERVYEPLYKNNDLLNTYDGLVPIYTFPDTGKFGASTIRFGSRGDSFYEYLLKQYLLTHETLYYDLYRKSMEGMKKHLLAQSKPSSLWYIGEREQGLHGQLSPKMDHLVCFMGGLLASGSTEGLSIHEARRRPFFSLSLERKSDWDLAKGITDTCYQMYKQSSSGLAPEIVVFNDGNIKQDGWWRSSVGDFFVKPLDRHNLQRPETVESIMFMYHLSHDHKYREWGAEIATSFFENTCVDCNDPKLRRFTSLSDCITLPTKKSNNMESFWLAETLKYLYILFLDEFDLTKVVFNTEAHPFPVLDEEILKSQSLTTGWSL
The following text describes a protein:
Function:
Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation.
Domain:
Consists of nine domains. Domain 1 contains two EF-hand calcium-binding domains. Domains 2-4, 6, and 8 are almost entirely alpha-helical, configured as a series of peptide repeats of varying regularity, and are thought to form a single-stranded alpha-helical rod stabilized by ionic interactions. Domain 6 is the most regular and may bind KIF directly by ionic interactions. Domains 5 and 7 are less well organized and may induce folds in the molecule. Domain 9 contains the C-terminus, conserved among different species.
Sequence:
MSPLLRSICDITEIFNQYVSHDCDGAALTKKDLKNLLEREFGAVLRRPHDPKTVDLILELLDLDSNGRVDFNEFLLFIFKVAQACYYALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFASVPVRSSPLYEYIQEQRSQYRP
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Sequence:
MERNIIAADEIPDRHPEDQVKQQSDEVKEAFEVETPQATKLENNRQDQQRPKPARRRTRKATSLAIDHEQTIISGDIYQSWLQSSSDIASRKRKKRKTLSVLPSMKIARMMEMPPIALLEGLFTNGNKEVHYPAPLLKLWMRNTQPPHDSPSGKTSPPFPPEPSYTSPGERMGNLEPPFEYFQGGVGSPAVGISIEKQRANLNNNKIPPEILMEDLRTNLTNMGLHPTETNGVKETDHMATPGSGDEPRSIPSSGSGHGLLSQNSVTDSSRSNKKRPHSSLKHSGNGLQPVAEENPWHDPTLNFKLTRLSELSENGFTQDNVCYEPPFTILAEILMETGPTQTQHPFITQPLDMMTDSIRIQLKSHFDTPGSAEAECLNELTLGMTKKQAACLFYQTCAQRNFIVSSFSLERINVCSILRAVLATRDFVKVEQELPYGNILISRGAKMYWRIEAQIYSSNFQEKHLVTAKNYGLPLFDLYKNGSGYFSYQKLKNHPKIGIRANDPRHFRPALIVSDGDMAMTMTTAMASPSRRLLINSRHSTICTIPKNVAIYPAAAVTNQGLLKHCISSQRCLRSLVKPVSAASSGFEADLGDDESLIRVKNAKIAVESEDDEKIQVRVDVSEEDTKTVFEKVLTNLAKSAPPVPGFRREKGGKTSKVPKDFLLQILGEDRVTNFVIREIVTSTLADYVKKENLAVKDNKISTTQTADELKSSFVPGTEFRFNATLELEKSKTEAST
The following text describes a protein:
Function:
Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
Miscellaneous:
MISCELLANEOUS: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.
Subcellular Localization:
Cytoplasm.
Sequence:
MKDILFEESNIKLNIEDQLRKIYKYSGFSEIISPTIEFYDVFNSNIQAIPQEKMYKLFDNLGRILVLRPDMTTPIGRITGTKMKDCTYPLKLCYTANIFRVNEKLNGKRGEIAQSGIEIIGTNGIKSDVDSIVTAINALLSLGLKNFKIELGEAGFFQALTENMEIKEENLKKLKEIIRNKNYVALKKFLDEISSKYSKEDFELIKNLPKLFGDIKIIEKAKALTKNKKALKSLDDIYNIYKSIENIGLEAYISIDLGMVQNIDYYTGVIFKGYVEEVGDSILSGGRYDNLIQHFGIELPATGFAINVDDIMIALKKQNTISMDKDKKVLIFYKEEFLRKAYDFMQELKMKKIICELSLLDNDKENLLYSKKKGIDFIIGFMGEEKLFVKDLKSDKIAFLKKDEIENLLML
The following text describes a protein:
Function:
Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store (By similarity). In neurons and glial cells, has a role in maintaining neuronal function and integrity during aging.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Endoplasmic reticulum. Mitochondrion.
Sequence:
MATWTQNEPTGVTKRRRWNLEDRASLNKLKHHIAEEGCPQMQYDLAKELLDNSIVEPNLAKGNQSQKAVNWLVSAAHNGHEDAVKLLRQCYNDGSGITAENTDEVRRCLAMTPGERAARKAARELFACLSNGNEHITPKQLERKMRRIYNLQRKRRRRDDDRSSSSSEGEQEPECEPLEDVPTIDLANVERRRLITEAHLVSAASNYSAGQMPSVNDALTLSVPDPRSLDHVPCFYRMIFHPLIFFTLFYHRLLNLIVSIPNVIPLSVRCSVLVAISWWSSRHMLPLVSYYLSLGIMIWATCKMLKTKQQFVDFRIWSGLFLSYGDQNIEADIAEHRFLRNNMKPYLYFFCAFICNLIVYPLVTDAWLPHSELTIISGALTFITMCVSMYASSHQLPDWLVIVSFAVNVLAKYPYEMDEVVSTRWRFLDLRVPTFSSFVIGNGIEFCLNCRTALYLFIPVLLIMMAKRSRWHGVYTFLIPHCVTLSWLQVCIATSQSSTVFGVMRAALGLAGIVLFLPLFGIVALLVPVFVAIDSLGLASEQLRWGSTALACGLVVVLSCILALNRATQKYITMLQLITAITTACLLVLPYMTSSFKDTPRFNAMPRAGLHSLSETNTLPWDRFHALCAQPVHEQPNKIKAQLRCSLLNGMPVIWEGSVTKVEISRVSNFLEDTIANYLPVWLGRMLRCLHGENISQHFKCDPKLDAQCEEWRSVFKTFNAQSGSCTLQRWNRYEYELLVKVGTKRSGRLLGRSTTTDVILRAHHDFGNFTRLLSEGDVVLFYGILHNSRLLADNVQVKLKTIECVECRSRDLGTASIERVVAASPMDARLQDLMRGIKYLLNALLNPLITFK
The following text describes a protein:
Function:
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
Sequence:
MAKVIFVLAMDVSGKIASSVESWSSFEDRKNFRKITTEIGNVVMGRITFEEIGRPLPERLNVVLTRRPKTSNNPSLVFFNGSPADVVKFLEGKGYERVAVIGGKTVFTEFLREKLVDELFVTVEPYVFGKGIPFFDEFEGYFPLKLLEMRRLNERGTLFLKYSVEKSHR
The following text describes a protein:
Function:
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MRLRLFLAASALALLSGCAGLTSHEALEGQGDAQTWKTHKQQLSELDAWQIDGKVGIRAPRDSGSGTLFWLQRQGYYDIRLSGPLGRGAARLTGREGAVSLEVAGQGRYQAESPEALLEEQLGWRLPVSHLLWWVRGLPAPDSKSRLTLDADSRLARLEQDGWQIEYTRYAEQNGYWLPERLKLHGQDLDVTLVIKDWQPRQLGR
The following text describes a protein:
Function:
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. Required for the transport via the ALP pathway, which directs the transport of the cargo proteins PHO8 and VAM3 to the vacuole.
Miscellaneous:
MISCELLANEOUS: Present with 13500 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Sequence:
MTSLYAPGAEDIRQRLRPFGFFFEKSLKDLIKGIRSHNETPEKLDQFFKQVLSECREEVNSPDLNSKTNAVLKLTYLEMYGFDMAWCNFHILEVMSSNKLQQKRVGYLAASQSFYKDSDILMLATNLLKKDLKYDGNNDVVKVGIALSGLSTIITPSLARDIADDLFTMLNSTRPYIRKKAITALFKVFLQYPEALRDNFDKFVSKLDDDDISVVSAAVSVICELSKKNPQPFIQLSPLLYEILVTIDNNWIIIRLLKLFTNLSQVEPKLRAKLLPKILELMESTVATSVIYESVNCIVKGNMLEEDDFETAMACLERLHTFCDSQDPNLRYISCILFYKIGKINTDFISRFDQLIIRLLSDVDVSIRSKAIELVEGIVDEDNLKAIVQTLMKQFVDEDVVILQTGSIVYEKSKRIPIIIPENYKIKMVNVIISICSADNYSSVNDFEWYNAVIMDLAMLCQDISDKSLGSKIGEQFRNLMIKVPSMREVTIANIIKLISNDNINKQLPTVLRECIWCLGEFSTLVENGNDLIKIMTENISYYSHSVQEVLILALVKVFSNWCNNFQEDKRFEIKMVLKELIEFFENLSYSSTFEVQERSVEVLEFLRLSLEALEEDTEGLPMLLSEVLPSFFNAYELAPIARGTQLKLAVDENLDLETPFLTKEAADELLDEQKSDAISDLMSDISMDEQVELKFVDDSDTSYEEKEKLDDFENPFEIEREKERMSNPYYLGEEDEERTKNSKDLLDLNEEESSDKKPETIRLNRTDNSLNSLSLSTTEISRKKKKGKKKNRVQVLSDEPVIEAAPKRKDAFQKPHDNHSTQNPLKKDKINLRMHSQLENFDFSNFGQSSNAGRGSQEEGNLRKEDELELSRLEANLIVKDEKDNLSDTEEVIVIKKKKKGKKSKSKNKLKTKAKNSPEPNEFLRDQSTDI
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEGTSKEQTQTVKAPMIYICGECHQENEIRPRDPIRCRECGYRIMYKKRTKRLIVFDAR
The following text describes a protein:
Function:
Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MFRLNPFVRVGLCLSAISCAWPVLAVDDDGETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRKGVSIRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLIDGVLGMKAYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQNHDFTAGYGFDRQDRDSDSLDKNRLERQNYSVSHNGRWDYGTSELKYYGEKVENKNPGNSSPITSESNTVDGKYTLPLTAINQFLTVGGEWRHDKLSDAVNLTGGTSSKTSASQYALFVEDEWRIFEPLALTTGVRMDDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGENKPLSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQKRADSATAKTPGGYTIWNTGAAWQVTKDVKLRAGVLNLGDKDLSRDDYSYNEDGRRYFMAVDYRF
The following text describes a protein:
Function:
May play a role in the trafficking of a subset of G-protein coupled receptors.
Subcellular Localization:
Membrane.
Sequence:
MGRTVIAEDLLQDRIQEILKTSGKGITTGLLVGQPHGQKREDYVVHLIRTPQIEEDSQQAGKKKKKGSTKPEGLDSQWIAEHAKQVQRMLPGGLNILGIFVVLPSEESRSIQSQLVQVLYTVHKTLLKTPWQKAVRTGGEEEEEQHRIVLQICSVTKKFTTKTFNVVDPRDSGTVAEWKFQSFVSQWPLLHTAVTVNINIPVLRGEATKTLHQQLDTSIGPFCECIMQGLCTFNGVLRKGDQPLQAQEPPQGKKGHGKGKGRHKESKTSHQPTSDGPEMFCVQILSKATNNKSKEAMVTECGGTVFIRGLIQARAYVHSKATVAQASQAIREDVVRSLTARCELLAEDVLEVKDFTADREEMDITPRRVFGQLYDTHLSVCDYMFEDEGVEDCIARCQELLDISLAPDDVENDAERLPEPEELEKPLCDMLGEEEEEDTDGEEVVNAQASWEKWKKSYIGTMIGAGIAVVVSGFFMYLEY
The following text describes a protein:
Function:
In insects, FMRFamide and related peptides have modulatory actions at skeletal neuromuscular junctions, and peptides that are immunologically related to FMRFamide are released into the circulation from neurohemal organs.
Subcellular Localization:
Secreted.
Sequence:
MGIALMFLLALYQMQSAIHSEIIDTPNYAGNSLQDADSEVSPSQDNDLVDALLGNDQTERAELEFRHPISVIGIDYSKNAVVLHFQKHGRKPRYKYDPELEAKRRSVQDNFMHFGKRQAEQLPPEGSYAGSDELEGMAKRAAMDRYGRDPKQDFMRFGRDPKQDFMRFGRDPKQDFMRFGRDPKQDFMRFGRDPKQDFMRFGRTPAEDFMRFGRTPAEDFMRFGRSDNFMRFGRSPHEELRSPKQDFMRFGRPDNFMRFGRSAPQDFVRSGKMDSNFIRFGKSLKPAAPESKPVKSNQGNPGERSPVDKAMTELFKKQELQDQQVKNGAQATTTQDGSVEQDQFFGQ
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MSEKLPPGTLCAVCDDIATGKHYSVASCNGCKTFFRRALVNNREFVCQGNKDCPVNKGVRCACRYCRLQKCLAVGMDKNSIQNDRDRIGYTKRKRRHDDNDMEGGVHHSEHIRDGSSGSPQMNDESPESMDMKDIKIDLNCLDPIADRLTTLENNFTLLLSRCADLHSYATLEDALNAPSRFMQPISCEWSDNVVLTNRDDKLPFWRQRLIALYIDWAKTFSTFRSLPYADKVAMVTNHASSFMIMCEAFRTPEHMKSDVVRKRPDLPNIVTSNSGSGCSRVSSVAGSLVSNGEDVHDDLTNLLHAACIQQSINKGIMFGENSSDDKILLNLPIREIKKEPLEVPSTEGMIQLPTEYGNLPADYASWIPQDYGHPTAGHEGKSDMHNFFEARDFCVGRPSSCNLNERSMKTVSMLESRNFQSPSANNSSLSGITPVLTMMIDLVMKPFRQLNFSTTEFALLQAIMFFDPDTEGLDSASQRNVVAEQKKLLAVLFRHLQKAYNPQAASERYASIILRMPSIRRAAAKKNESLQVLDMLQMHEINSLVKETSLGPRPSNVQQRMGIGGGAGGCLTFPSQED
The following text describes a protein:
Function:
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Nucleus.
Sequence:
MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASRRSDSASTEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGENRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEHLLED
The following text describes a protein:
Function:
Plays an important role in galactose metabolism.
Sequence:
MPGRGLPTGVVLPEAGDLLRVELEAPGRAGGGGPAAQHLDEERGGGHGEGHSDGARPRQAPHPGRGGRHASSASEGPLGRRQSSSKGQPITAAGPFPLSARDRKQPMAAPFACHFPSSLAFVCVTQLYRPMVVGGSYIHPADVVESARLIGGGLTVPRHLPPSTNRGWDRSRERPGRRSKRSKMASEAKFHPSEHQHLRYNPLRDDWVLVSAHRMRRPWQGQVEEPTQDDVPRHDPANPLCPGAQRANGKVNPDYESTFVFDNDFPALQPDAPEPDADGHPLLRAASARGVCKVMCFHPWSDLTLPLMSLAEIRNVVDKWTEIAVELGASYSWVQIFENKGAMMGCSNPHPHCQIWASNFLPNEATLEDRTQKQYLAKHGVPMLLDYAQLEAERKVMSAGVQKERGLESQCSHSLFCWGLLQERIVVENTDWLVVVPYWATWPFQTLLLPRRHISRLQDLQESERDSLASIMKRLLSKYDNLFQISFPYSMGWHGAPTGSYLDADCSHWQLHAHYYPPLLRSASVRKFMVGYEMLAQAQRDLTPEQAAERLRNVPEEHYRLKEKDAS
The following text describes a protein:
Function:
Putative transcription factor. Binds to specific sequence motif 5'-[TC][AGT]TGCC[GA][AT]-3' in regulatory elements of target genes such as myosin myo-2. May modulate gene expression, perhaps acting in opposition to transcription factor pha-4. Involved in morphogenesis, perhaps especially in formation of the pharynx. Plays roles in molting, feeding and morphology.
Subcellular Localization:
Nucleus. Note=Localization to nucleus dependent, in part, on FLYWCH-type domain.
Sequence:
MLGLEKPLSSDISSSSTDTSAISPISVSSMPLSPDKEKKKIKFIRYNPDIPQIVTSFKGYQKLMYQGYRYNIYQVVPEKNFKSWRCVCAKKMPDDGQWCKCRAETTSDNSNACTKNTHNHPPKHRVAEIEFIKSQLINAAFENPDHDAGDLINQACMYLSEGVSFDNKESLKKSLVSARNKEGKPRKPKSKTSTNPLKRMKIEIEEEDENVFKMQRMDNDITGFLPLLNNSISMVKVESPFSTTPTIQIPPPNPPQIHQPQEHSNLLQPAALNGFNNSWMGGIEDPIAMFWANAMLNPSGLDVLSTIAALSKHQLHSQGPTQAATAPAAPLSSNLSVSSFTPQMPKEASMAIPPTQILNLKDLKPLPPLAAIQTSPVIQAASLLRPIPMKNDMGTQTVEEIKVSRCLTSGCGCRVIRICCCDEGRCRRAAAC
The following text describes a protein:
Function:
Functions as an E3-type smo-1 ligase. Mediates smo-1 conjugation to air-2 in vitro and is required for proper chromosome alignment. In the early embryo, specifically suppresses checkpoint activation in response to DNA damage, maybe by promoting mus-101 sumoylation. In embryos, plays a role in determining telomere localization in the nucleus. Acts with pie-1 to promote piRNA-mediated silencing and fertility in the adult germline.
Sequence:
MLPNNQWQIPINNGLTHQENMAAHAAVMKLRVHDLQSIISQLSLRKPRPQKSEHQKVVVESLRDPHHARQIYQMASNFPNGNYEMQKRPATTSQVRSHPYVLPSRSGASNHLVNHHYQQQQQQQPQPHNLLHQQMMASHHSHLQQQHHPSTVRWLTPELLEEQLRGSMRYGAPAAAAATNAPLHSSFPNHGRSSQQSLQKSEKSNRPKKMYADNFEPLPLPFYDVISVLLKPVELHSSDSPTLKQTKQLQFPFLLTAEHISKISYRADVTPLPRYELQLRFFNLTEPVQGPQKDDFPLNCYARVDDSVVQLPNVIPTNKTNAEPKRPSRPVNITSNMNRYKKEHTVAVEWLADKRVWAAGVYFVHRVNSDILFKRLNQNVSRHRSLEVTKQEVIKKLSGGEDDIAMDRLNISLLDPLCKTRMTTPSRCQDCTHLQCFDLLSYLMMNEKKPTWQCPVCSSNCPYDRLIVDDYFLDMLAKVDKNTTEVELKEDGSYDVIKEEAFCISDDDDDDVVPATVNGTASCSSTNGNGLANEAAKKKPADDDIITLSDDDDEELNRGIMNSLNDSFSPGRHTASAELAAQKTPPQQKKKTKDDDIEIITLDDTPPRPVAASANLPMRQMSQQNQMPVGSSPSGMASTQMGMNEGASKTIRDALNKIGEQSANSSTQSSPLVQLHHTTHPLNFAQSSYMNPSSGSQTPTSQYGYSPMINQAPHFQMQNGLIGRNNQMVHMQQHHLQQQQQQQQSPQIMSPSFYAQQQMSNGGAFAYYPPQYPQQQYRQN
The following text describes a protein:
Function:
Involved in pre-rRNA processing and ribosome assembly.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKSSKKSAVEVAPTSVSVSEGKSGKKGKRNAEDEIEKAVSAKKQKTVREKVVPSKEEAKKVKKQPPPKKVESSSSEEDSSESEEEVKAQPKKTVQPKKAAQPAKEESSDDSSDDSSSDDEPAKKPVARPNKAALSTNSSSSDDSSDESLSDDEPVKKPAAPLKKPVALATNGSKKVETDSSSSDSSSDEESDEDDKKTAAPVKKPSVAAIQKKTQESDSSDSDSDSESDEDVPTKAPAVAKKKEESSESSDSESDSDSDDEAAAVKKEEESSDSSDSDSESESDSDEPAKPTIPAKRPLTKDTKKGQSKDESEDSSDESSEESGDEPPQKKIKDSTTSGTTKPSPKATKKEISSDDESDEDDSSDESSDEDVKQKQTQAKKQAPVAQESSSSDESSEEDSDMESDEPAKTPQKKETAVSVGSNKSATKPGQEEPKTPASNQNQATGSKTLFVGNLPYNVEQEQVKQFFQEAGEVVDIRFSTFEDGNFRGFGHVEFATAEAAKKALELAGHDLMGRPVRLDLARERGAYTPGSGRDNSSFKKPAQSSGNTIFIKGFDTSLDIHQIRNSLEEHFGSCGEITRVSIPKDYETGASKGMAYMDFADNGSLSKAYELNGSDLGGYSLYVDEARPRPDNNREGGFSGGRDFNSSGRGGRRGGRGDGSRGRGDRGRGRGFGRGDRGHGGRGTPFKQSAGTPSAGKKTTFGDDD
The following text describes a protein:
Function:
Regulatory protein, which plays a central role in chromosome stability. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESP1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESP1.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
Sequence:
MMPANEDKENNIVYTGNESSGINFPQTPAHLLKRSHSNILKPPVRLDQLKRDANSNNGNTLKYIQGGKEVSPTKRLHTHAQQQGRLPLAAKDNNRSKSFIFPETSNQSKDADLPQLQNTLSIRKNDQLRKLSQISRSRSRANHNDLLSNSRKLQKYGSVLGYNALPKMKSLVLKDLADSGKNEESSDDDEGNEDSESKLGKKLQSALLKQDSSDGENELNGGLGLFNEQGGLQQLIKNSTKNEQKTKNDKSDKTDDYDIEIAPQRQEPLPYVPEGYSPFQQDDIEKLKTFNSPYKLDLEDEDDTPDKVDLLPLEQIDEEGEKDETECITRNQEEGAALPLLSKNFKEVAAVPTMELVYSEEGLDPEELEDLVT
The following text describes a protein:
Function:
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MYEGKHIHYSEVDHKPLCSYSPKLCKQRRLNGYAFCIRHVLEDRTAPFRQCEYVAKYNSQRCTNPIPKAHDRKYCNSHLQVMGVLPKKERKKKQDTIESLALNITVPSLALKTHNGLEILPPSPPPALVCLLPSDPFSFYKEEKMLKSSGAFLKKPQETLNHKQKQQDHSVDTNHLRTSSLPSTLSHSCLPPLLTGRATQTPINPSSPRAATPTVRSGSLFKTSSSLQDTHQGSKDSTDNKIKLDLNHAFDKKVVPAASGMAPCCDDTQSQLIKKCTVAMQQQAPCLKKLHRLMDQHKGRFQDLNSHLGLDWSEDSEEEDGDWKLVSYQCQRLQEKRSEESRSWAERLAGFCSYLRQKHMHLCREQRGFRRERRSQHALRKALVQAAREEPHQTAQLIQEQHQVTSAPSSTAVSLAGDDSGLCQAVVKGENCRNSALPFTRHCFQHILQNRSQQLFSSCTARFADGAQCSIPVFDITHQTPLCDEHAKKMDNFLRGDISRRTYHHHQQIQRHRPLKKAKPPALSKKHKKKGKRGTQRRPQKPIPPALPQGNLALPSILCLPSQPSGIRSPLTPDLSADEFPDDITNDISDIPHDLELNQEDFSDVLPRLPDDLQDFDLFEGKNSELLPTSEEAEELVRVLQAMGSYPESLACLSGMAELGPVEGVDCRSMPGGVVDLLSARLSAETLSSLELDPSLLHPSEDAFPPSPPSPQPPLTPPSSVGHLTDSTYTQRQPHLLAKMEDSKADLANLPLGKDEDVSHGSWGVLALPLSDSSQFHSLIASDGLLMPTGLSTPCQPSSALSALPQSSQTRSTTTSPTSQTKHLPPPPTVQALWDPSRLTAAP