lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI and GAP activities on G(i) alpha subunit Galphai. Confers GAP activity on G(o)-alpha subunit Galphao and G(i) alpha subunit Galphai. Involved in the dorsal-ventral axis formation of the egg. Acts as a G-protein signaling for glial cell differentiation during embryogenesis; Galphai, Galphao and the G-protein coupled receptor, moody, are required in the surface glia to achieve effective insulation of the nerve cord. May be essential for nurse cell dumping during oogenesis. Required in neuroblast asymmetrical cell division. Plays a role in stress resistance and life span control.
Subcellular Localization:
Cytoplasm. Cell membrane. Apical cell membrane. Note=Recruited from the cytosol to the plasma membrane by the G(i) alpha subunit. Colocalizes with moody at the plasma membrane. Localizes as a crescent to the apical cortex in interphase and forms an apical crescent and segregates into the apical daughter cell at telophase. Colocalizes with Galphai and raps/pins at the apical cortex throughout mitosis.
Sequence:
MHHHHPPLPITGASGSTAVGTGAAAAEDASPAANSGPAPISTSTTPSGSNSQQHQRRRKKRANYNYNGIRTVEVRRGYNGFGFTISGQQPCRLSCIISSSPAEQAGLRSGDFLISVNGLNVSKLPHETVVQLIGNSFGSIRMQIAENYYSDSSDEENAHATLRGQLLAASLRHKPRFLHHKAKLHRLRNSPQKKLNPPEAVEPHKSKSSPDHPTLKPVLEDPPLTANLSKAADVANVSAMVRAVGSAALECRVIVGYLGTIEMPKQISHSSKLQTVRSCIRKLRQEKRQPTIVLMCITPDSLSLQSSSGGVLATYSSARLNFVSSSSESENRFFGLVTSAVHNTQIEEEYEPSAGSAAAAGHISISHSCHVFVIDTKLIEHAQHLQRAHEFRLQCTRDPISNLCLEFPNNSEYVVNLVRSMYTMRILPPASRSHQADYEAGAGAAAAGGAVAAAHSPQPSNHSEISTTTSNSDSGIGFNNDCTNISDRILVVDFLAAGAGAAAAAHAGPPTYPAPARPLGIVGIPDNRLTVRAMPDHSALLRSPPASSSLRRPNLLASFNLIQSPATNLTSTRSCDDVLNLFVDDSPRTLAAVASMDDISLHSAAPSLDEGHTFAHPACVPRKMRRSLALETPTTPHKLSAQVFGQPGSRHSLGFEAIDSVQSSVSGACMDQTMDTWASLQNLHKSHKDRTSMSASSSSHCLLEATNSEPDLGNRALPANASPFRRAWGQSSFRTPRSDKVAKEQQQLGQSSPVRRTASMNASDNDMYIKTLMLDSDLKSSRSQHQLSLLQVPKVLTTPAPPSAITASVAAEGAAQDHGCPSSWAGSFERMLQDAAGMQTFSEFLKKEFSAENIYFWTACERYRLLESEADRVAQAREIFAKHLANNSSDPVNVDSQARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYSGLDLDELLKTNFHLGAFSKLKKSASNAEDRRRKSLLPWHRKTRSKSRDRTEIMADMQHALMPAPPVPQNAPLTSASLKLVCGQNSLSDLHSSRSSLSSFDAGTATGGQGASTESVYSLCRVILTDGATTIVQTRPGETVGELVERLLEKRNLVYPYYDIVFQGSTKSIDVQQPSQILAGKEVVIERRVAFKLDLPDPKVISVKSKPKKQLHEVIRPILSKYNYKMEQVQVIMRDTQVPIDLNQPVTMADGQRLRIVMVNSDFQVGGGSSMPPKQSKPMKPLPQGHLDELTNKVFNELLASKADAAASEKSRPVDLCSMKSNEAPSETSSLFERMRRQQRDGGNIPASKLPKLKKKSTSSSQQSEEAATTQAVADPKKPIIAKLKAGVKLQVTERVAEHQDELLEGLKRAQLARLEDQRGTEINFDLPDFLKNKENLSAAVSKLRKVRASLSPVSKVPATPTEIPQPAPRLSITRSQQPVSPMKVDQEPETDLPAATQDQTEFAKAPPPLPPKPKVLPIKPSNWGVAQPTGNYCNKYSPSKQVPTSPKEASKPGTFASKIPLDLGRKSLEEAGSRCAYLDEPSSSFV
The following text describes a protein:
Function:
Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MEGIRQEGSSGARNGANAANATGSSNLHARPTVADLHGENHFAQVARKNWLTAKKTPKVRPEVVKKELWDELEDGDFAYSSLLILENLQLLERYLWPGFTEDASNYHHLLLALMINVKRRENLASWGKELCSQHFASKPAEFSSFFRRILSMTVDPAQPSKIRTQLVSFVIGAFQSLDSGLVRKECAPLVGISIWQNLHADAVREAQFEEHQMLRKAWRATSKRFDAADEALQARLRFERTWLYSLVLDFINRLYNSTTKEEIRDNLAYCERFMELLTDLESQLPTRRYVNTLLKDLNLLPAIRLSPLYTDEENGLFRDLFNLLHHFANFPIEDQTGKQLSKLEYDQQHYDILAKLQRTGYAAFQEKLQLMALANYGSIGNREELHGHLQVLSDDELVQLCALMDLRTEYPASTFLVRDRTFYMEALLSLVEQKPTFKDTVRDMPILPTEKILYETTFLRNESYDGSRPLAIPKLNLQYLTMGDFLWRSFILYRAEALYGIRKDMEDVVKRVKPRGKGANSKFGGISKMSLPIMKPAVVDVAPSKVGDEHPAYVRAEIVLDVSRLQHGVRREWEQLKTGDVVFLVAIEGQDDVPMRNGNNNGLNSGEESGLHKLRCAQVVQVLDENGRPLREQVHTDGFAPRARQRRLLVNIDAKQYQHDMDNTAEGRPNVYEHMNHIVRRRGRENNFLPILESIKRLTLSDIPAPSWLQEVFLGYGDPASASYQRLHNRLHSIDFRDTFLDWQHLIESLPGKSIEPHEEAQTSFGPPYVVQYPAAAEPEIAPAKPSKKRRRDQVEVAQPMHQSLHVSTYKPPNMGPYPADAQKLNTVRFTPAQVDAITSGTQPGLTVVLGPPGTGKTDVATQIISNIYHNFPDQRTLLVAHSNQALNQLFQKIVALDIDERHLLRLGHGEEDLQTDASYSKHGRVESFLERGQYYLSEVDRLARNFGAPGAHSSSCETAGYFNLVYVKPAWTQYWDSVSSDESSVEQIVAEFPFRDYFSNAPQPLFPPTADRSQALDIAQGCYRHVEKIFTELEDIRPFEILRNPRDKANYLLVKEARIIAMTSTHAAMRRQEIADLGFHYDNVIMEEAAQITEIENFIPLALQNPQNGELPLQRIVLVGDHLQNSPVIQNLAFRQYANLEQSLFQRLVRLGVPTIALDQQGRARASLAELYKWRYPKLDNLPSVLSSPEFQIANAGFKYDYQFIDVPDYKGKGEQEVAPHVLANEGEAEYAVAIFQYMRLLGYPANKISILTTYAGQKALIGEVLGRRCKGNPLTGMPRIVATVDKYQGEQNDFIILSLVRTRSIGYLRDIRRLTVALSRARLGLYILGRRSVFESVFELKPAFDVLFQRPDKLSLITDEMFGETTRPAAALDVEGEAVMEGVEHLGKYVYDMQNAKFEALKANGGQLPTREINMRDAVVDEDGEENVLIPEEVGDDFGEDEDEDFEVRSSGRHLEVQATSSVQLD
The following text describes a protein:
Function:
Essential hematopoietic-specific regulator of the actin cytoskeleton. Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages. Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells. Within the WAVE2 complex, enables the cortical actin network to restrain excessive degranulation and granule release by T-cells. Required for efficient T-lymphocyte and neutrophil migration (By similarity). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin. Also involved in mechanisms WAVE independent to regulate myosin and actin polymerization during neutrophil chemotaxis (By similarity). In T-cells, required for proper mechanistic target of rapamycin complex 2 (mTORC2)-dependent AKT phosphorylation, cell proliferation and cytokine secretion, including that of IL2 and TNF (By similarity).
Subcellular Localization:
Membrane; Single-pass membrane protein. Cytoplasm. Note=Localizes to the leading edge of polarized neutrophils.
Sequence:
MSLTSAYQLKLAEKLTILNDRGQGVLIRMYNIKKTCSDSKSKPPFLLEKSMESCLKYINKKFPNIDVRNSTQHLGPVHREKAEIIRFLTNYYQSFVDVMEFRDHVYELLNTIDACQCHFDINLNFDFTRSYLDLIVTYTSVILLLSRIEDRRILIGMYNCAHEMLHGHSDPSFARLGQMVLEYDHPLKKLTEEFGPHTKAVSGALLSLHFLFVRRNQGAEQWRSAQLLSLISSPPAMINPANSDTMACEYLSVEVMERWIIIGFLLCHGCLNSNSQCQKLWKLCLEGSLYITLIREDVLQVHKVTEDLFSSLKGYSKRVADIKESKEHAITNSGQFHCQRRQFLRTAVKELETVLNDEPGLLGPKALFAFMALSFIRDEVTWLVRHTENVTKTKTPEDYADSSIAELLFLLEEIRALVRRHIKVIQQYHLQYLARFDVLVLSDIIQNLSVCPEEESVIMSSFVSILSSLNLKQVDNEEKFDFSGLRLDWFRLQAYTSVSKAPLHLHENPDLAKVMNLIIFHSQMLDSVEKMLVETSDLSTFCFHLRTFEKMFATTLEEPTMLRYTIAFPLICAHFVHCVHEMCPEEYPHLKNHGLHHCNSFLEDLAKQTSNCVLEICAEQRNLNEQLLPKHCATTISKAKNKKSMKQRQAPRKGEPERDKPGAESHRKNRSLVTNMDKLHLNLTELALAMNHVHSFSVFEHTIFPSEYLSSHLEARLNRAIVTLAGYNATTQEILRPSELLAGVKAYISFIQSLAQFLGADASRIVRNALLQQTQPLDSSGEQTVTTLYTNWYLESLLRQASSGAIVLSPAMQAFISLPRDGEQNFSAEEFSDISEMRALAEILGPYGMKFLSENLMWHVTSQIVELKKLVVENMDILVQIRSNFSKPELMASLLPQLTGAENVLKRMTIIGVILSFRAMAQEGLQEVFSAHCPFLMGPIECLKEFVTPDTDIKVTLSVFELACAAGVSCDIDPALVAAIANLKADNSSPEEEYKVACLLLIFLAVSLPLLATDPSSFFSIEKDGYNNNIHCLTKAIIQVSAALFTLYNKNIETHLKEFLVVASVSLLQLGQETDKLKTRNRESISLLMRLVVEESPFLTLDMLESCFPYVLLRNAYREVSRAFYLNRLPASSH
The following text describes a protein:
Function:
CDK-activating kinase that modulates CDKD-2 and CDKD-3 activities by phosphorylation of the T-loop. Activates CDKD-2 C-terminal domain (CTD) kinase activity. Activates CDKA-1 probably by phosphorylation. Possesses a CDK kinase activity independently of association with cyclin CYCH1-1. Phosphorylates the CTD of the large subunit of RNA polymerase II.
Sequence:
MDKQPATSWSIHTRPEIIAKYEIFERVGSGAYADVYRARRLSDGLIVALKEIFDYQSAFREIDALTILNGSPNVVVMHEYFWREEENAVLVLEFLRSDLAAVIRDGKRKKKVEGGDGFSVGEIKRWMIQILTGVDACHRNLIVHRDLKPGNMLISDDGVLKLADFGQARILMEHDIVASDENQQAYKLEDKDGETSEPPEVIPDYENSPRQGSDGQEREAMSKDEYFRQVEELKAKQVVRDDTDKDSNVHDGDISCLATCTVSEMDDDLGRNSFSYDADEAVDDTQGLMTSCVGTRWFRPPELLYGSTMYGLEVDLWSLGCVFAELLSLEPLFPGISDIDQISRVTNVLGNLNEEVWPGCVDLPDYKSISFAKVESPLGIEGCLPNHSGDVISLLKKLICYDPASRATTMEMLNDKYLSEEPLPVPVSELYVPPTMSGPDEDSPRKWNDYREMDSDSDFDGFGPMNVKPTSSGFTIEFP
The following text describes a protein:
Function:
Required to regulate morphology and anatomy during seed maturation.
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MVKMGEVWTNTGSALASLVFIYTIFERFFPYRLREHFEPLAQSLIGFIYPYIQITFHEYSGERFKRSDVYDAIQSYLSKDSSSRAKKLTANTIKGNKSIILSMDDHEEITDEFQGVKVWWQSKKHQSESRAISFYPKADESRFYMLKFHRRDREVITKKYLNHVISEGKTIEVKNRERKLYSNNPSQNWSGYKQTKWSHVTFEHPATFDTLAMEYKKKEEIKNDLIKFSNSKDYYKKIGKAWKRGYLLFGPPGTGKSTMIAAMANLLEYDVYDLELTTVKDNTELRRLLIETSGKSIIVIEDIDCSLDLTGQRKQKKDEEEDEDETSPIEKQMKKDQGENKGSKVTLSGLLNFIDGLWSACGGERIIVFTTNFIDKLDPALIRKGRMDKHIEMSYCGFEAFKVLANNYLDAKEEDDNELFDEIKRLLEVEEIKMTPADVGENLLKKSEVETKEICLKRLIEALKEEKEEAKRRIEDEEKKKKEEEEIKRKKREEKKIKKEEKEEKEENETTMKD
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MDTPSPSSSPKAPLLSTKNRSSLSNGNSSSLSSIKPTPHSAANPPPLSKTSPETMSKKRKWRISSSTTSPSLSKPAKTSSPSIPKPNPYFLTTCSVETTLKTAIPEPSSSATSLYRPHKEPTIIFKPNPSSHSKIKIKTEPEPSTSLSRHRKEPTIIFKPNPSSRSKIKFKTKPVTTTKERERKRSKCSSSAMVCEICMDHKPYEETFSNPTCSHTHCNECITKHIASKLQENLTLIECPVPSCKQVIEIESCMPFLPKEVFERWSAVLSEATILGSNKYYCPFEDCSGLLEFVEGENINIKESECPYCNRLFCARCKVPWHSGFKCEEFEMKDDDDLFIKLAMEKKWTACPNCACVNFATDVDAPGNSNTHANRSDH
The following text describes a protein:
Function:
Mediates recognition and avoidance of Streptomyces species by detecting dodecanoic acid secreted by the bacteria. Also mediates avoidance of decanoic acid which is not secreted by Streptomyces species but this may represent an additional important avoidance response in the environment.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNDCDEVNNISYDPLYRYSQFYTLLTSIFSVFPLLYLIIFKLRVCTFNDNIKFLYIVYFTQILISVLNNCVVFAHHVVIPFLAVSKCDLLVNPVKNRIFQNIGVFGISCPMLTILGITAERLLALIFARCYENVKLHIGVFIGVFAMLCDMALVYFFFLDEKFDQPSISYFMVPDTSGYKMNWLCYSLLAINSVNLVFNYFLVKINTILKEKWRNSLSTRYQMEENIITTKFSTFISFIHVFFFSLYLIFTLIIRLLGPGFLKTQADLMSVRGVYITIPTYNLIIGIASCVILRHLQRQKVAKVYAEVTLKYSGIDGAQIHQEAILNVWKTKSSGRK
The following text describes a protein:
Function:
Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MSKRVRSSLILPAVCGLGLAAVLLSSCSSKAPQQPARQAGISGPGDYSRPHRDGAPWWDVDVSRIPDAVPMPHNGSVKANPYTVLGKTYYPMNDARAYRMVGTASWYGTKFHGQATANGETYDLYGMTAAHKTLPLPSYVRVTNLDNGKSVIVRVNDRGPFYSDRVIDLSFAAAKKLGYAETGTARVKVEGIDPVQWWAQRGRPAPMVLAQPKQAVAQAAPAAAQTQAVAMAQPIETYTPPPAQHAAAVLPVQIDSKKNASLPADGLYLQVGAFANPDAAELLKAKLSGVTAAPVFISSVVRNQQILHRVRLGPIGSADEVSRTQDSIRVANLGQPTLVRPD
The following text describes a protein:
Function:
Required in determination of cell fate during sensory organ formation in embryos. Restricts developmental potential and promote maturation of intermediary neuronal progenitor (INP) cells probably acting as an antagonist of Notch signaling.
Subcellular Localization:
Nucleus. Cytoplasm, cell cortex. Cytoplasm. Note=In larval brain, shows asymmetric localization and asymmetrically sized divisions in type II secondary neuroblasts.
Domain:
PTB domain recognizes multiple ligands by engaging different amounts of surface area dictated by tertiary contacts rather than primary sequence. This may allow interactions with a diverse set of proteins during asymmetric division and specification of cell fate; The phospho-regulated basic and hydrophobic (PRBH) motif is necessary and sufficient for interaction with phospholipids permitting cortical localization. Phosphorylation of the PRBH motif by aPKC inhibits the association of the protein with the cortical membrane.
Sequence:
MGNSSSHTHEPLERGFTRGKFGDVKNGKSASFRFSKKSPKKMDRLRRSFRDSFRRRKDRVPESSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEALKVLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNHERGFSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNSTFTRTGSFRQQTLTERLAMATVGTNERSVDGPGSAMPGPPAATVKPFNPFAIERPHATPNMLERQSSFRLSTIGSQSPFKRQMSLRINDLPSNADRQRAFLTAAAGNPMQTPLRSVSPIAEVSPAKSAGADPLSAAAVAADSVSQLCQELSQGLSLLTQTDALLAAGEDLNFNNNRSINQNIIAAEKQVQHVHSYAPPTAQVTPRVASTTPTYQTLHSQSPSRSEQSIETSTELPNAEQWLGHVVRSTSPAAPKRPTYLANVGRAQTLASGTGAAVGGGGPDDPFDAEWVANVAAAKQLSPDLPIPSTARSPLARHSTNPFISPPKAPAQSFQVQL
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MAVQDTELVHFLNKWSVSGGVAGKESYIIHLELTVMDVNDELPEWTMDPLPPMGVVSPNAAAGTYVYKLQATDKDEGVSGEVEYFLLEGGDDRFAVDRSTGWIQTTGLPLLENKEYLLTVQAADMLGKKSAPIVVSVIAGLRPPQFKKASYSIHVPENVSPGYVLLTVSALSHQNKSISYSLVRNPENLFSVHQLTGAVTLIQSVDYEREPKELLLVVRAMEHLEQLSSTAEVHVFITDVNDCIPEFQQTIYSKDNVAENAAVMTSLLQVMATDCDSGFNSEVSYYTESADFSISAQGIISPVRALDYERPGHLYEFVILAVDKGDKPNTGTATVRIRISNVNDEAPEFSQTIYRTFVSEDASPNTLIATVHAFDGDGDWVTYDIVEGNKDGNFVIDPQKGLIRLHSSLLPSHHETEYILYVTATDDNSSGGPSSLTSTATVIVSVDDINNNKPVFHKCASYRDHAAVLENQPPGTFVLQVEAKDADYGVNGQVKYGMVHKEGTLPAFSIHPDTGIITTVQSFDREKQKEYPITIKATDQAAEPLIGLCQINILILDENDNDPSFENNRYEYFLREDTSVGTSFLQVAAHDADYGSNASITYATSGEEPMIFKVNSSTGWLYVNHSISRRPLITQEVIATDGGNRSTKVEVAVRVTDAQNQPPVWEKGRYEIVVPENTVRDTAVVTVKATSLLGDPRVTYNLEEGLVPESNMPVRFYLTVNREEGSASVLIAEPLDYETTKNFILTIRAQNVAPVPLAAFTTVYINVTDVNDNVPFFTSSIYEASVTEGLGLGTFVLQVSATDQDLGLNGEITYSILEDRNGDHVLFHIDPQTGSIFTASVFDRETRSSYLLEIKSSDGSESARPGKHGQPNSDTAYVRIFISDVNDNKPSFTQSAYYVNVDEDQDVGYIVITVTAHDPDEGVNAKIRYQITAGNIGGVLDMDPDTGSIFIFQPLDYEEVQIYELTLLASDGKWEDFATVTINVINKNDEAPVFSHNEYHGHVTEEQSKLPVLVMQVSASDPDNGAHGSLKYSLHGKGANNIFTIDEERGNVFVQKALDREEHGLWRFVVLATDEEGEGLTGFADVIIYVVDINDNAPQFTCALSSCNANVYENAPPNTTVLEMTAVDADDKNEEINAILTYSMLNNTMNLFSINANTGTIYTLGNLDREKNDKYVLLVKVIDGGGLATTGTATISVLDINDHVPRFTQDSWNSVILETNDINTKVLEVSASDEDIGENALLTFSIIDGDPDQKFTIESDRMTNQAEIKLKKKLDYENPQERWFNLTIKVEDPDFSSLSFCFIELQDCNDNAPVFLAPFVQLSPVLENVTIGTVLTQVIASDADSGINGQIRYSIWPSSDVLGEFFVDPAGFVKVKKALDREVDSQYHLVILASDEGFPSQTGSATVSFSLLDVNDNGPVFDGLYTPVIWENTAWPQIVHMNESSDLLYASDYDTLENGPPFRFSLPSEYTNSTDFLLNDNGNNTATVHALRAFDREKDKEFYLPIIITDSGNPPMSATNMLLITIGDENDNPHRGGHKDVYINSYGGWSAVELGKVFAPDEDDWDNKTYTSVSKMPVQFRLNQNNGSLVMLEKAHQGTYDIKIKVSDGVWPEVMSTVRIHVKDITKEAILNSVSLRLTNITAQEILHKDEYGFSTYEQLQMAIAAVVPAHPSNVQIFSLENTEGHQTDMRFAVRESSTFYKPDVLQSVLSAHRGKIQSILKSNASYVEVDFCLPQDCGNAQECTSYSAFTENPSLVDTGRISFVSVAHNANTICRCSLRDRVHQSCSSMLQNPCLNGGTCRDTNNGYRCHCLPQFHGPLCQQTQRTFNGNGYAWFPPIRHCTDSHLSLEFISDKHDGLLLYSGPIFNQPSGNDHNFFAIGILRSVPTVTIREGTSTLHLQFPASVNVTDGTWHRIDMRIKKKIVSVILDRCSSSVINEKEGVGKEFLIEDRTNCEVSGLIRQEMRFWNPHSVLQLGGVKESTPPSYRQLPYQHFKGCLRNVILNKQMYDLGVSLESINSFPGCSVKDPACSLASPCEVPPRCTKESGLTSCDCLPNGSGYDCEKDVNEYYFQLGSSVHYQLPHVLPTQRTYFNAMVRTRHANSIILSLTSRDRTEYIQLQMMAGLLTVSYNIGDGDLMVQLPDHKIDTGEWNEVTMERIQNEFTLRVNQGNRQREITDAPGTYKEIKVDPNSIILGTDSSHLLSFQGCMKDARLNNYRLPMENHTISAVSIINIHGVREGCLSKACKENPCSKDFICIDLWMMHKCSCPSGYLHIENETKQGCIYTECASTPCKHGTCVAQSPTDYVCHCSNGYAGSKCDVLLQISDPGFGFSIFLTIGVCVLCLIVVIVGVFMWSHCNNKRKNQGVYHVSAYNEELEDTRQNIFQYNEEGGGEEDQDAFNMTELQLSLQSSPVNTLCRTMRTRHLNSPLSCDYHTSISQEEPSQLPPSKPSCSFTSGDFGQYFYDIFKDTTYLQQALSCDSLKIYDMEGDGSIASSLSTLASSGVEEDLVFEEIHDWGPKFGKLSKLYSYTEEDDLQ
The following text describes a protein:
Function:
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MPGGCSRGPAAGDGRLRLARLALVLLGWVSSSSPTSSASSFSSSAPFLVSAVSVQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTSYVFLGIVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV
The following text describes a protein:
Function:
Formation of phosphoenolpyruvate. May be involved in regulating the flux of carbon into starch and fatty acids of seeds and in the remobilization of nitrogen reserves in senescing leaves.
Miscellaneous:
MISCELLANEOUS: The reaction takes place in three steps, mediated by a phosphocarrier histidine residue located on the surface of the central domain. The two first partial reactions are catalyzed at an active site located on the N-terminal domain, and the third partial reaction is catalyzed at an active site located on the C-terminal domain. For catalytic turnover, the central domain swivels from the concave surface of the N-terminal domain to that of the C-terminal domain; MISCELLANEOUS: [Isoform 1]: Translation of the sequence shown in PubMed:16915520 was N-terminally extended; MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage. Cytoplasmic; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing of isoform 1; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing of isoform 1.
Subcellular Localization:
Plastid, chloroplast. Cytoplasm. Note=Isoform 1 is targeted to the chloroplast while isoform 2 is found in the cytoplasm.
Domain:
The catalytic core domain alone is sufficient for the binding to PDRP1 but not for the binding to PDRP2; The N-terminal domain contains the ATP/Pi binding site, the central domain the pyrophosphate/phosphate carrier histidine, and the C-terminal domain the pyruvate binding site.
Sequence:
MLYIRKKMTSMIVKTTPELFKGNGVFRTDHLGENRMVSRSNRLGDGSNRFPRTGTIHCQRLSIAKTGLHRETKARAILSPVSDPAASIAQKRVFTFGKGRSEGNKGMKSLLGGKGANLAEMASIGLSVPPGLTISTEACQQYQIAGKKLPEGLWEEILEGLSFIERDIGASLADPSKPLLLSVRSGAAISMPGMMDTVLNLGLNDQVVVGLAAKSGERFAYDSFRRFLDMFGDVVMGIPHAKFEEKLERMKERKGVKNDTDLSAADLKELVEQYKSVYLEAKGQEFPSDPKKQLELAIEAVFDSWDSPRANKYRSINQITGLKGTAVNIQCMVFGNMGDTSGTGVLFTRNPSTGEKKLYGEFLVNAQGEDVVAGIRTPEDLDTMKRFMPEAYAELVENCNILERHYKDMMDIEFTVQEERLWMLQCRAGKRTGKGAVKIAVDMVGEGLVEKSSAIKMVEPQHLDQLLHPQFHDPSGYREKVVAKGLPASPGAAVGQVVFTAEEAEAWHSQGKTVILVRTETSPDDVGGMHAAEGILTARGGMTSHAAVVARGWGKCCIAGCSEIRVDENHKVLLIGDLTINEGEWISMNGSTGEVILGKQALAPPALSPDLETFMSWADAIRRLKVMANADTPEDAIAARKNGAQGIGLCRTEHMFFGADRIKAVRKMIMAVTTEQRKASLDILLPYQRSDFEGIFRAMDGLPVTIRLLDPPLHEFLPEGDLDNIVHELAEETGVKEDEVLSRIEKLSEVNPMLGFRGCRLGISYPELTEMQARAIFEAAASMQDQGVTVIPEIMVPLVGTPQELGHQVDVIRKVAKKVFAEKGHTVSYKVGTMIEIPRAALIADEIAKEAEFFSFGTNDLTQMTFGYSRDDVGKFLPIYLAKGILQHDPFEVLDQQGVGQLIKMATEKGRAARPSLKVGICGEHGGDPSSVGFFAEAGLDYVSCSPFRVPIARLAAAQVVVA
The following text describes a protein:
Function:
Probably not involved in maintaining the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP, RMEV, AVK and HSN neurons.
Subcellular Localization:
Secreted.
Sequence:
MTKLCLLLLPLVFLVSYSFAEEEITISISPNANPVQKPIGHQISLVCSIKKTDSNGEKPGMIWKKHGGLDRTGNVEVKKLDDYTLGLIIRNSSVEDSGVYYCQAQVGSKVYMNKMDVIVFEDIVFRDKQLHFGQVLATASVNISCEVSAKKDSVITYWTRHGKQILEGGKHKFYSRGSILEIQNYQPEQDAGQYTCEVFHVSSGSSNTKTVTLGTTGEKNYVACQQMCNSFCTDVHNKVFTNN
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDADWDADDFEPELNLKGKSTDKWAGEDEEEVKDNWDDEEDETEDQKSSKPEHQVLTTVAPPKKKKSLKEKLAEKEEQKRKEAEDKLEKKKLEVEERKQLTPKELMEEKMKRQKIQEEADLALAIEAFGLDKDDEQKNKKTGEIESFEPNTKEDFDQLKMLLKNKLIKYEKSPLYVSFLESLFRDLVLGVEADNVRKLSTTLTALYNEKLKISKTKPKKKNLKKASLVMEANTLENYDDDAAYDYDDLI
The following text describes a protein:
Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins. May play a role in preventing corneal damage caused by ultraviolet light.
Subcellular Localization:
Cytoplasm.
Sequence:
MSVWILHWGRSISVAGPSHPPGQLLLRIPRLGALRMQSPLWQLCHPLAPGGGGPRAPWSRGTKGMVGTMSKISEVVQRARAAFNSGKTRPLQFRIQQLEGLRRMIKEREKDIAGALTADLHKNEWNAYYEEVVYVLEEIEYMIKKLPEWAADEPMERTAQTQLDESYIHWEPLGVVLIISAWNNPFNLAIQPMVGAIAAGNAVVIKPSELSENMANLLATIIPQYVDKDLYAVINGGISETTEVLKERFDHILYTGSTGVGKIIMMAAAKHLTPITLELGGKNPCYVDKDCDLDIACRRIAWGKFMNSGQTCVGPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIINSHHFQRVMGLMEGQKVAYGGTGDAATRYIAPTILTDVDPQSQVMQEEIFGPILPIVCVRSLEEAIEFISQREKPLALYVFSLNDKVIKKMIAETSSGGVTANDVFVHVTLHSLPYGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLLNDESLKARYPPSLVKMAGH
The following text describes a protein:
Function:
Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
Sequence:
MSRFLQAEINLKSLIHNFSKIKAHLRNTRVSCKIIAIVKADAYGHGAVEVARVFGLLGVDYLGVAFSEEAIVLREAGIKVPIIVLFDREIEGVFKYNLIPVIFDYRQAEFLSKEASRRGVILPVHIKVETGMGRLGIYENPCETIKKIAQLDNLKIDGVMSHFSRAEDLEWTQEQMKKFSKIREFLHNLGMKPLFHIANSQGLNYKEALFDAVRPGLMLYGYGAEGFIPCMTVKTKLLDIRKLPKGTPISYGGTFVTKKDSLIGVIPVGYADGYFRSLSNKAEVIVRGKRVPVVGTVCMDLTMIDLTDIQEVQIDDEVILLGKTGSEEITASHIAQWAGTIPYEVLTSFGGRARRKYIMEEEE
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Miscellaneous:
MISCELLANEOUS: Deletion causes telomere shortening and senescence.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MTEHHTPKSRILRFLENQYVYLCTLNDYVQLVLRGSPASSYSNICERLRSDVQTSFSIFLHSTVVGFDSKPDEGVQFSSPKCSQSELIANVVKQMFDESFERRRNLLMKGFSMNHEDFRAMHVNGVQNDLVSTFPNYLISILESKNWQLLLEIIGSDAMHYLLSKGSIFEALPNDNYLQISGIPLFKNNVFEETVSKKRKRTIETSITQNKSARKEVSWNSISISRFSIFYRSSYKKFKQDLYFNLHSICDRNTVHMWLQWIFPRQFGLINAFQVKQLHKVIPLVSQSTVVPKRLLKVYPLIEQTAKRLHRISLSKVYNHYCPYIDTHDDEKILSYSLKPNQVFAFLRSILVRVFPKLIWGNQRIFEIILKDLETFLKLSRYESFSLHYLMSNIKISEIEWLVLGKRSNAKMCLSDFEKRKQIFAEFIYWLYNSFIIPILQSFFYITESSDLRNRTVYFRKDIWKLLCRPFITSMKMEAFEKINENNVRMDTQKTTLPPAVIRLLPKKNTFRLITNLRKRFLIKMGSNKKMLVSTNQTLRPVASILKHLINEESSGIPFNLEVYMKLLTFKKDLLKHRMFGRKKYFVRIDIKSCYDRIKQDLMFRIVKKKLKDPEFVIRKYATIHATSDRATKNFVSEAFSYFDMVPFEKVVQLLSMKTSDTLFVDFVDYWTKSSSEIFKMLKEHLSGHIVKIGNSQYLQKVGIPQGSILSSFLCHFYMEDLIDEYLSFTKKKGSVLLRVVDDFLFITVNKKDAKKFLNLSLRGFEKHNFSTSLEKTVINFENSNGIINNTFFNESKKRMPFFGFSVNMRSLDTLLACPKIDEALFNSTSVELTKHMGKSFFYKILRSSLASFAQVFIDITHNSKFNSCCNIYRLGYSMCMRAQAYLKRMKDIFIPQRMFITDLLNVIGRKIWKKLAEILGYTSRRFLSSAEVKWLFCLGMRDGLKPSFKYHPCFEQLIYQFQSLTDLIKPLRPVLRQVLFLHRRIAD
The following text describes a protein:
Function:
Required for nuclear export of the ribosomal subunits. Required for maturation of the RNA components of pre-ribosomes (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
MAEVNEPLQIELRKIRNSSTAGVINEFDVIVSAVEGTLKEQKTEATPTAYLVALLTLVKEFTDLKKNFKGHTFQLLELVIKYVPSNVLQAKFPQILSVLAPVVNNAETNKTVLLPYLNVLEKLLLLQDYSSWTHGNSCKTSIYILLFFALSNTEKTRVRSLQILANILKNPPAGPVTEHPAIKYTAFEPLRLLESLATAKKPKTPAEVQKLNNSLVLIRVLCSSTHWPMTLVERLCRSCVLIVGQRSTNSILLVYQILDGLSKKSVDYTDAVSLRMTLICLQKLEPSEHDPILMVGWLKAMNTAIRAFNILDKETAKYECLHRFKAFFTLLESESMEIRLQTATTICSVIGCLDTTPNSFAVVEEICSFICDALRDIRFRLAYPECFQIISSLCDKLGPHSDPYLIPALEVIDYLRGSEGFDGKALVDEAIGSFVRAIGPEAMLRVLPLNLELNDKDAVGRAWLLPVLRDNIRFANLAHFTNYFVPLSGQLYQKVIEMNDLDSIPSKLLQTLVDQIWSLLPGYCYLPLDLQSSFTLEFASILVNVLYEQVSLRSVICNSLTALVETNSKVADKLPLDDVISVPVSASDASSNLAFLTNMSSNFLSVLLNVFSSTPSQYRYPILKCIQTWIFISSNDTIHSVYKKVTDLLPDSLNDLAGSFNIAADGISSPMAYSLIDLLIVISPYLNQDYAVTLFEYVHEFLRHVNPAIQKKGYKLLGTLLRVDYGKAYATQHVKEIFEELSSVADRVVSSTRKDRLASLNALYELQSSELVIAIPQLLPEAIISLKEVNEKARHTAFQLLFNIAKSAVNSVEFGNSKPERVEKFVSVISAGLAGSSTHMISATIIAISSIVMEYKVFISEPFLVQLISTLNLFITSSKREIAKAAIDFIKISVSSFPVECIKPLLPELIPNLLAWSHEGKANLRVKVRHLFEKMGRKYGIAEIEPFFPAEDKKLITNIRKTQERNIRKRAMKRDPAKPSSAQPRKTFASAYEAAVYDTDDEAEEEFENDEMNNGNGGDLRMDEAFVQEDNDEEPLDLLDIEAVSKISSTDPRKKLAARKQKLNSAFKSNEEGRLLINDSDEDELIEDSLANAQQHAEVNRTYLEAVAGKESFRRGLNNRVKFSNKRVRDDYDEEMEEVEVPEVTRKPAKQKFDRKQRGQKGY