lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MPLLRGRCPGRRHCRRLALLGLQPAPRFAHSEPPRQRPLSAAEMAVGLVVFFTTFLTPAAYVLGNLKQFRRN
The following text describes a protein:
Function:
Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cell projection, dendrite. Cytoplasm, perinuclear region. Perikaryon. Postsynaptic density.
Sequence:
MGNNFSSVSSLQRGNPSRASRGHPQNLKDSIGSSFPVPSHRCHHKQKHCPPALSGGGLPATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFYRINESAAMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLRCEADEARLSVSLCDLNVPGADGEDGAPPAGCPIPQNSLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVARLEHGRDERALVFTSRPVRVAETIFIKVTRSGGARPGALSFGVTTCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAPAGMQLCVDASQPLWMLFSLHGAITQVRILGSTIMAERGGPSLPCSPASTPTSPSALGSRLSDPLLSTCGSGPLGGSAGGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGHMCLCYSCGLRLKKALHACCPICRRPIKDIIKTYRSS
The following text describes a protein:
Function:
May play a role during anther development.
Sequence:
MADCTTMRLASSVTIILLLLVASQALVVSGESSSSAMQSKTLNMNKLLNISEDHSPNGGRHWMQRMQPDSCSEQNVVVYQNNAEHLPSGIPTYSVEIINVCTACTVYDVHISCGEFASAELVDPSQFQRIGFNDCLVKGGGRLGPSEAVSFQYSNSFAYPLAVANVACE
The following text describes a protein:
Function:
Required for biogenesis of the 60S ribosomal subunit.
Miscellaneous:
MISCELLANEOUS: Present with 32400 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MIRTVKPKNARAKRALVKREAKLVENVKQALFIPGQSCNKNLHDIMVDLSALKKPDMKRFNRKNDIHPFEDMSPLEFFSEKNDCSLMVLMTSSKKRKNNMTFIRTFGYKIYDMIELMVADNFKLLSDFKKLTFTVGLKPMFTFQGAAFDTHPVYKQIKSLFLDFFRGESTDLQDVAGLQHVISMTIQGDFQDGEPLPNVLFRVYKLKSYKSDQGGKRLPRIELVEIGPRLDFKIGRIHTPSPDMVTEAHKKPKQLEMKTKKNVELDIMGDKLGRIHMGKQDLGKLQTRKMKGLKSKFDQGTEEGDGEVDEDYEDEASYSDDGQEYEEEFVSATDIEPSAKRQKK
The following text describes a protein:
Function:
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MASSSSKPDHASKDMKTDGSSTLSAAKKSKRNRKICLKRLPKHNDKSMVTGRIKLPDMLVEQSWLEALPDEFQKSYALALCMFVGNEYFAFKDSVYPPPHLIFDAFNTTPFHSVKAVILGQEPYSGPGQAMGLSFSVPRGVQFPSTLKNVLKEVKNDLDCKVLRHGNLEKWALQGVLLLNAVLTGRINENNANAHANIGWEQFTDAVIKTISEKKEGLVFLLWGEYAQEKIRLIDQTKHHILKAEHPSGATVKGGFFGCKHFSKTNQYLEQNGIGPIDWKF
The following text describes a protein:
Function:
Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAAAVSSAKRSLRGELKQRLRAMSAEERLRQSRVLSQKVIAHSEYQKSKRISIFLSMQDEIETEEIIKDIFQRGKICFIPRYRFQSNHMDMVRIESPEEISLLPKTSWNIPQPGEGDVREEALSTGGLDLIFMPGLGFDKHGNRLGRGKGYYDAYLKRCLQHQEVKPYTLALAFKEQICLQVPVNENDMKVDEVLYEDSSTA
The following text describes a protein:
Function:
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions.
Miscellaneous:
MISCELLANEOUS: Partially functionally complements S.cerevisiae CRD1/cardiolipin synthase (CMP-forming), but conversely is not functionally complemented by S.cerevisiae CRD1.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MTFNGRFRATLRGINIRNASMTSLSLTGSHAQKQTVLGSTPGALGTIPTVALNGVNPLPRYRHNLLFGTLSFGDRWDRIQRRLAVLGRASTGNVVVPFSDSADAFRRMWESVDSASDSVLWQTYICKDDFVGQKTVKKLEEAHRRGCKTELLYDCGGNITGRRRLVGDLKKSGANVIEHRPMWEHFFPYFLRGMKWELSPGIRNHRKILIVDNKLGFCGGLNIGDEYCGTSEGGNGRFRDTHCVVMGPAVMHMREVYEDTKAPKPWKWSLARWRQIASATMNLRYLEGMNVKHDYLEPTTTFVRQGGGVYLRRQMERAERSTVRMMERMRWKRQRERLNRCLLTLAKNLREGQGLVFKAATGKGDDVATTDAGSKRNNEVSHGQWKLMKRRIDEYRQRAIKNAEESFFRRLRVVNPSMRLLEDTSPVAEAEAYGQAHAAVTQVLSCNPHSRDWSIPYAFWQVSKFVHQRLWVTTPYYMPHRKLMRALQLAARRGVDVRILAGSNRTTDPWFMWYASNYITGMLMASGVRVYEYKGGQVMHAKTVVADSIWTSIGSYNWDMMSNKNMEICVCHLDHNLALTMEKQFLDDMNVSEEVNYEEYQRRSLWLRFSSWFFYTALRIAEKFTFRTFWDPDLSSEID
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MDAALLLALGLLAQSLFPSAGVPRLRRPRTLYPWRQAPTLGRVRRAWVIPPISVSENHKRLPFPLVQIKSDKQQLGSVIYSIQGPGVDEEPRGVFSIDKFTGKVSLNAMLDREKTDRFRVGPAPPRPFLHHSCTIPAGAPPTPPPARLASLVGGSGQGLGPVPTEAGVQGRSRIGQMRVSRLRSASCLGGLGSRQQGERQLSQLRAFALDLGGATLEEPTDLEIVVVDQNDNRPVFRQEVFTGRVLEGAVPGTYVTRAEATDADDPETDNAALRYSILEQGGPQLFSIDPLTGEIRTVQVGLDREVVAVYNLTLQVADMSGDGLTATASAIITLEDINDNAPEFTGDQFFMEAAEAVSGVDVGRLEVEDRDLPGSPNWAARFTILEGDPDGQFTIRTDPRTNEGVLSVVKPLDYESREWYDLKVAVQNEAPLQAAAPRAERGQARVSVQVRDVNEAPVFQENPLRTSLAEGAAPGTPVATFSARDPDTQQLQRLSYSKDYDPEDWLQVDGATGRVQTQRVLSPSSPFLKDGWYRAIILARDDASPPSTATGTLSIEILEVNDHAPELSPPWGSLCSTPDRGSGLLLGATDEDLPPHGAPFHFQLSPRVPELARNWSLSQVNVSHARLRPKLRVPEGLHRLSLLLQDSGQPPQQREQPLNVTVCRCGQDGACLPGAAALRAGGAGISLGALVIMLASVILLLLLALLVALLARFRQQSWDKRLLHGLQDDLRDNILNYDEQGGGEEDQDAYDIDQLRHPAELAAFGAPLGRPPLRRDAPFGRARPQVTRALPTSPADIADFINDGLEAADCDPSVPPYDTALIYDYEGDGSLAGTLSSILSSLDDEDQDYSCLREWGPRFSRLADLYGPP
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MADDDPGAAVAAGLTIPEGCIRRIKLSVVSNEEIAQPVDAQGKPFPITHGSQLQDNPSLGLPLQVGSCESCGATQLDRCEGHFGFIELPAPIYHPSHVAELGKILNIICLCCLRLKKPNEKGTGKERKFSSCSYCQDIPPLCVTQVKKSNGARSLELKAPLKEEVGDGFWSFLDQFGFHTILTSHRRPLHPKEVQNIMEKISKQTKIRLAARGYNLQNGFVMSYMCVPPNCLHISNLLDDNTDMYPPDTSKGLLQKVLRIIEQIKSSSISHPNFEACEVGEDDLQVAVADYINMGGTAKGTQSVTFSRQPAPKQWQQRMKALFISKSSSFTCRAVITGDPYIGLDVVGVPNEVASRMSVEEHVTDYNIARLQYMMDKGLCLTYTDVNSNTYDLSGEKGRKKHTMLRVGETVDRRVLDGDLVFLNRSPSTDMHSVQALYVLLHDDHTIKINPLICGPLGADFDGDCVHIFFPRSVSARVEATELFTVENQLVNSHNAKLNFQIKEDYLLALKIMCDRRYSREEANQIAMFSSGMIPPGDPYWTISQILQTTGSLITLPSHPNKESVGALVTAIISSTLKGKGPREAIKLLNLLQPLLMESLLMDGFSMSLRDFNGPSAMQKVIQSTSLELDELRESTVDFIAHYSALGLLVDPKSDSALRKLVEQLGFLGRQLQNNGRLYSSNLVEDCYKFMNKCSGSTKCYDPLKAHDVVKSSFYNGLNPYEELLHSISVREKIERSSSKGLAEPGNLFKNMMAILRDVIVCYDGTIRTSCSNSIVQFDSTDVSSSVTPGPGDPVGILAATAVANAAYKAVLDPNQNNMTSWDLMKEVLLTKASSISDTIDQKEILYLDKCFCGFEFCMERAALRVQSCLKRIKIEDCATEVSIKYHPEATQAAHCLVGHIHLDKEQLNRMEITTEHILQKCQEVISKHEKKSRQMRQIWKTTEMISSEYCLYDQDIGDEEALQVSCLEVFLDTSTTTGLSESNVAHLMTNTIFPILLDTIIKGDPRVQDAKVIWIEPESTCWVQNSSAEQKGELALEITVEKVAVAESGGTWGVAMDACVPVMDLIDTKRSMPYNIQEVHKVFGISCVFDRVTQHLSKAVGMVTKSVITDHLTTVASSMTCTGSLHGFNRSGYKATFQSLKIQAPFTEATLSRPMQCFRKSAEKVDSDQLASVVSTCSWGNHAAIGTGSAFKIHWKDEIQSSSDEILGGYGLYDFLALVGTIGAAELKTVTPHSSCLYDVDKIPEDEVQEDEVVCLGGNLPISWTDKTKADSLLHDFKGRSTGIHRTRQESQGTQNKSDWNSVANWKNDRPRGPLHSAFAGSTSTNEWNKRRFTDHVFERKQPKHSWSSAVTHQDDKPSWSSKNVAGAQKHGITLSSSSGGWNKKNSGFGRGGSRGMRKSEGSHSGGSNSRNWRAQNNSSARQGGISYSFTPVEQQIYAQVEPIMKNVKRIIRESSRDGVKLSQDAEMFIVNKVLMYHPEKEKKMAGQGNYIMVAKHQTFHSSRCLYVASSDGSSSDFSYKKCLENFIRIHYPDSADSFCRKYFK
The following text describes a protein:
Function:
Opens both the alpha- and beta-forms of N-acetylneuraminate (sialic acid; Neu5Ac) to provide aceneuramate, the preferred substrate for NanA (Probable). Has preferential activity on the beta-anomer rather than the alpha-anomer. Accelerates a reaction that is spontaneous at slightly alkaline pH, facilitates the reaction at acidic pH (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MIISSLTNPNFKVGLPKVIAEVCDYLNTLDLNALENGRHDINDQIYMNVMEPETAEPSSKKAELHHEYLDVQVLIRGTENIEVGATYPNLSKYEDYNEADDYQLCADIDDKFTVTMKPKMFAVFYPYEPHKPCCVVNGKTEKIKKLVVKVPVKLI
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Sequence:
MAVEKVEAYLTRKQNSAKGPVADDWKNLNDHYSKKLWHQLTVLTRALVKKPAFVAGVDMTEFYDNFVSEWELRANPLQLVEICIPISENIAIKDRPKSLEFLQGQSRYCPFAHREIASRLVSKDANGQIPDLKEIRAQIDFTQKEVDALVGVTEVHAPFYRVSALYLREIGDFAGYYREALRYLGVEDAKNLSAEEKQVHAVLLGFAALLGENVHNFGELLAHPIIKALEGSREQWLVDVLLAFNAGDLPRFFSLENNWGSWDDMKRKKDFLTAKIRLMAIMELALARPTKARSISFKEIASKCQIPFDEVEFLVMKALSKDLIRGDINQVEQVVYVSWVQPRVLDSSQILAMASRISEWRKDVNLMEGIVSKEAREILTQN
The following text describes a protein:
Function:
Potentially involved in docking of synaptic vesicles at presynaptic active zones.
Subcellular Localization:
Membrane; Single-pass type IV membrane protein.
Sequence:
MRDRLNEFQSRVTDRFDEVELSPARPPSAAEYVDRRFEEVRNAIASVRGEIEKLRRDQQHVLALTIADPRDKNILENQIGTIRRRTGDLRKLVRQAEDDFLEFTKQVQSVTEKRMRQNQLELLKDNLNKLINLFNETHQDYKSRVSVRVRRQLQTVGQDLTDEDINRIMENSGSEQLFFREVNPLSVSGQAAYEDVKKRHGEIKDLENNIAMLEEIFLDLQHLTEAQDEMVTNIDNNVENGLEQVKQGSANVKTAVEYKKSAMRKKICVAAILITILLILIIVAIILAVVLSRGNNNNK
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
AASNHLSDVSFASLPITQKSKDVLTRDMGYEFLTHVQKDTLPLVLEGRDVLAKGKTGNGKTIAFLLPTLERMLKNPQQTQGKISALVISPTRELAQQIAVEAVKLTDAHGLRTSCFVGGSSVNKDIKELTKPGGIDVLVSTPGRLQAHLQDDSGHIRKRLDGLKVLVLDEADRLLDMGFRPDIMRIISRLPKQRQTLLFSATLPTATEELKDVALRDDYAFVDTIEGDDQQTNTQAVQEFVVCALQDVIPVVEGVLEEHMKLAEYKVIVFLPTARAAQFMAQLFQAAGFPNVLEMHSRKSQSARTKAADAFRKGKKMIMFSSDVSARGVDYPDVSLVLQVGLTDRDQYIHRLGRTARAGMEGRGVLVLADFEKALLRDLADLPLTELEQHPQLDKQNYRTTRALAKLGTGSQLEQSAEKAYAAFLGFYNSNLKKLGMSKTDLVETGALYSQLIGLDEVPMLQKKTLRAMGLMNTPGLVA
The following text describes a protein:
Function:
Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity).
Sequence:
MEKERETLQAWKERVGQELDRVMAFWLEHSHDREHGGFFTCLGRDGRVYDDLKYVWLQGRQVWMYCRLYRKLERFHRPELLDAAKAGGEFLLRHARVAPPEKKCAFVLTRDGRPVKVQRSIFSECFYTMAMNELWRVTAEARYQSEAVDMMDQIVHWVREDPSGLGRPQLPGAVASESMAVPMMLLCLVEQLGEEDEELAGRYAQLGHWCARRILQHVQRDGQAVLENVSEDGEELSGCLGRHQNPGHALEAGWFLLRHSSRSGDAKLRAHVIDTFLLLPFRSGWDADHGGLFYFQDADGLCPTQLEWAMKLWWPHSEAMIAFLMGYSESGDPALLRLFYQVAEYTFRQFRDPEYGEWFGYLNREGKVALTIKGGPFKGCFHVPRCLAMCEEMLSALLSRLA
The following text describes a protein:
Function:
E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of atg12 to atg5. atg12 conjugation to atg5 is required for autophagy. Likely serves as an atg5-recognition molecule (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MLTSKDFRDQAINLIKKWNNIIDEIPWQWNQINELNNESKGYFTTKRYHKINNNNNNNNNNNIENKNNNNIENFEEIKETIDDSSTTIIKSNNNNNENNIIIFQFDIIYSKSYQVPVLYLNGFSSFDSSPLSWNEIWNNLPLSNLDKNQQSTIPYITQVEHPILGNPCYQLHPCETDNLMKLILLKEKDYNDNNDKKEYFKDYYLLSWLSIIGPMVNIKIPFDLLKNNNI
The following text describes a protein:
Function:
Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MGITSRQKTPKKPFQTSFLPINGVSEPERSASNSDTDSMQEGPSHAEANGGSVGLLERERPIKGMDAMALEEVIRGRSDRVKKLLSIYREQYWLLMEELRYKYREYSWRFGKCGFDEKKDERERKEEREREGEAGVGSKLEREGGVRCLYQSCKAKPMALCDYCHAHVLSDSKQQLYKGCSYVIKSLPSGAVICGKPVLKATVPSLCSNHVLKTRRNVALSLKKAGLGMPSSNKHASKFHVMIAEYVRFIQAKRRRLRNGFSSGVSEIKPDT
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MASWDDEDFEVPAAATPAVPANWDDDEEEDVMDSWDAEEPTKAPGPKTTVAAPKKAQRQQIAKIEREMAAMKLKPEDASTKRDRQRQAELDSDMMNASELFGGTGGIADSAAKAEAAPAPAAPAAPMKLSDLAIFHPKEKKDFTNLKETLAPILTDLNKTSPLAYPDFAITFTKALAEPLKVEQLRKLISTLNAYQNEKIREEKAARGKKKKPGLAAASAKINDDKDTSTFNDNFDDFDDFM
The following text describes a protein:
Function:
Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (By similarity). Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution (By similarity). Plays a role in the regulation of cell shape and polarity. Plays a role in cellular protein transport, including protein transport away from primary cilia. Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MEEPLGSPPAALSALEKNVAELTVMDVYDIASLVGHEFERVIDQHGCESIARLMPKVVRVLEILEVLVSRHHVAPELDELRLELDRLRVERMDRIEKERKHQKELELVEDVWRGEAQDLLSQIAQLQEENKQLMTNLNHKDVGFSEEEFQKQEGMSERERQVMKRLKEVVDKQRDELRAKDRELGLKNEDVEALQQQQTRLMKINHDLRHRVTVVEAQGKALIEQKVELEADLQTKEQEMGSLRAELGKLRERLQGEHSQNGEEEEAEIQPQPDGEESISDAEKAALDLKDPNRPRFTLQELRDVLHERNELKSKVFLLQEELAYYKSEEIEEENRIPQPPPITHPRTSPQPESGIKRLFSFFSRDKKRLANTQRPTHIHESFGQWAITQRDDGYTEQGQEALQHL
The following text describes a protein:
Function:
Acts as a transcriptional repressor. Interacts with ERF7 to repress genes in abscisic acid and drought stress responses. The heterodimer represses transcription by tethering SNL3 to DNA.
Miscellaneous:
MISCELLANEOUS: Loss-of-function mutant (antisense inhibition) leads to abscisic acid hypersensitivity in germination.
Subcellular Localization:
Nucleus.
Domain:
The PHA domains are required for interactions with ERF7 and HDA19.
Sequence:
MVGGGSAQKLTTNDALAYLKAVKDKFQDQRGKYDEFLEVMKNFKSQRVDTAGVITRVKELFKGHQELILGFNTFLPKGFEITLQPEDGQPPLKKRVEFEEAISFVNKIKTRFQGDDRVYKSFLDILNMYRRDSKSITEVYQEVAILFRDHSDLLVEFTHFLPDTSATASIPSVKTSVRERGVSLADKKDRIITPHPDHDYGTEHIDQDRERPIKKENKEHMRGTNKENEHRDARDFEPHSKKEQFLNKKQKLHIRGDDPAEISNQSKLSGAVPSSSTYDEKGAMKSYSQDLAIVDRVKEKLNASEYQEFLRCLNLFSKEIISRPELQSLVGNLIGVYPDLMDSFIEFLVQCEKNEGLLSGILTKSKSTYLLQGEGKYPQPSLDNDRDQEHKRDDGLRDRDHEKERLEKAAANLKWAKPISELDLSNCEQCTPSYRLLPKNYPISIASQKTEIGKLVLNDHWVSVTSGSEDYSFSHMRKNQYEESLFKCEDDRFELDMLLESVNSTTKHVEELLTKINSNELKTNSPIRVEDHLTALNLRCIERLYGDHGLDVMDVLKKNVSLALPVILTRLKQKQEEWARCRSDFDKVWAEIYAKNYYKSLDHRSFYFKQQDSKKLSMKALLAEIKEITEKKREDDSLLAFAAGNRLSISPDLEFDYPDHDLHEDLYQLIKYSCAEMCSTEQLDKVMKIWTTFVEQIFGVPSRPQGAEDQEDVVKSMNQNVKSGSSSAGESEGSPHNYASVADSRRSKSSRKANEHSQLGQTSNSERDGAAGRTSDALCETAQHEKMLKNVVTSDEKPESKQAVSIERAHDSTALAVDGLLDQSNGGSSIVHMTGHCNNNLKPVTCGTELELKMNDGNGPKLEVGNKKLLTNGIAVEITSDQEMAGTSKVEREEGELSPNGDFEEDNFAVYAKTDFETFSKANDSTGNNISGDRSREGEPSCLETRAENDAEGDENAARSSEDSRNEYENGDVSGTESGGGEDPEDDLDNNNKGESEGEAECMADAHDAEENGSALPVSARFLLHVKPLVKYVPSAIALHDKDKDSLKNSQVFYGNDSFYVLFRLHRILYERILSAKVNSSSPEGKWRTSNTKNPTDSYARFMTALYNLLDGTSDNAKFEDDCRAIIGTQSYILFTLDKLIHKFIKHLQVVVADEMDNKLLQLYFYEKSRRPETIFDAVYYDNTRVLLPDENIYRIECRLSTPAKLSIQLMCNGLDKPDVTSVSIDPTFAAYLHNDFLSIQPNAREDRRIYLNRNKRKVCREDEQLYSTDEVKIKNGLECKIACGSSKVSYVLETEDLLVRVKKRRKTLCHNQDSWVRQMRLQYYKNNFL
The following text describes a protein:
Function:
Required for formation of the pseudocleavage furrow during the first cleavage of the embryo and also mediates aster-induced furrowing during cytokinesis. Promotes cortical recruitment of ani-1 and nmy-2 during pseudocleavage and cytokinesis and promotes the accumulation of actin at furrowing regions. Regulates establishment of embryonic cell polarity.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cell cortex. Cleavage furrow. Note=Highly concentrated in interphase nuclei. As well as a significant cytoplasmic pool, a distinct cortical localization is also detected, particularly at ingressing pseudocleavage and cleavage furrows.
Sequence:
MSAPKKRKSDIHSDDRDHADHQTKKEKHWFEEKSEQNGENRRSSIFKGFLKKVKSSTTLKSTNKSASSSKMDTIANETHLSITSESSITSVESCHSAQFPNVAKNAMLRTLVNRDSFTPVPPPDGESVTFILPEIGSSKLEFTSKMDDAISIESRMSIGSCHTIDEDSASIGSTSVFCTPSRNPLMRNGLRMSTRSVPENQDDMPPALFRSLCNSAVRRVPTSKSEGGGTPMRRSMRMSIQKRNLSSKNMEDVPEEEALTVSNSSIRVDAPIAEEDEEVFGAAKEYFDNNVTSHNDSADEGTCSMSRLSTTSERASGVGGSSIFQGRRSSIFRKIFPGKSESKDRRMSDNNQASEQYMDKKSRRASVVSFNEFTSVSGLSVNDSASKNPKDLTESPQQPKLRKKTASSSNLSQRISSVFRMGSNSTVKLNEYVPSPIVSQSSRRNTLTGNSSISSGVGSIASGTSDQGYGTIGSRSGQSISRCGSRRDDEGKKERTRRLLDRIIISDVPAGELLKLKIEQVKKQKQLEMDELFETQLTESSSSDTSQSENLQFDVVAVDIKADGSPFSTTAATFMDSELSKRVKEEIVSNYRPDRCGSITEYEPELVFVMPEQPQASLKSLNDSVSSNADINLDHLRNVRSGLCKSIEEWKRITKMRESSTMLIYPMFCQSEEEWDSKGTIDAIFLMLDGILMNTKRWMPNGKCILAGVTPNNVILLRNKFDELKLSVAISESDGPASSNDDFDTQSTASTSTVFGAKI
The following text describes a protein:
Function:
Probably participates in a plant defense mechanism.
Domain:
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Sequence:
MEMKNMVVGLFLIAAFALPALATSFEKDFITHETVQAILKKVGPSSNGMLDEQAISALTGKTIISNPVLEEALLTHSNSINALGGTLPCGESCVWIPCISAVVGCSCKSKVCYKNSLA
The following text describes a protein:
Function:
Voltage-dependent peptide-sensitive high conductance rectifying cation channel with a strong affinity for TIC32 that is imported into the chloroplast. Conductance is pH-dependent decreasing with decreasing pH values.
Subcellular Localization:
Plastid, chloroplast outer membrane; Multi-pass membrane protein.
Sequence:
MDSATRNPNYSPEVDPQPLPSTNPIHSRPIFSFPKRPALRITTEFDSESTVFFHKISCKFLDSLAKLKFAFHNNSKGEIAEPQISFVSKYLSLHYDLEDHSALVKSSVDVGPKLKLIGTHDVKAQQGEVTMVANLDDPGYALQLSTPLPSIALPKATFKFPQGEISLQEINDHDEDEQVKNSLSVSGTLKGQLLKGLCTAQYKDQEFKLRYRYKDDEMSFLPILSLPSNALSFAFKRRFGPSDKLSYWYNCDSNYWSAVYKHTYGEDFKFKAGYDSEVRLGWASLWVGDEGGKAKTAPMKMKVQFMLQVPQDDIKSSVLMFRVKKRWDI
The following text describes a protein:
Function:
Component of chromatin complexes such as the MLL1/MLL and NURF complexes.
Subcellular Localization:
Nucleus.
Sequence:
MTSASTKVGEIFSAAGAAFTKLGELTMQLHPVADSSPAGAKWTETEIEMLRAAVKRFGDDLNHISCVIKERTVAQIKATVKRKVYEDSGIPLPAESPKKGPKKVASGVLSPPPAAPPPSSSSVPEAGGPPIKKQKADVTLSALNDSDANSDVVDIEGLGETPPAKKLNFDQA
The following text describes a protein:
Function:
May play a role in signal transduction of hyperosmotic response (Probable). Can phosphorylate BZIP46 in vitro. Together with ABI5, PP2C30 and PYL5, is part of an abscisic acid (ABA) signaling unit that modulates seed germination and early seedling growth.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The C-terminal region is necessary for the kinase activation in response to hyperosmotic stress.
Sequence:
MERYEVIKDIGSGNFGVAKLVRDVRTKELFAVKFIERGQKIDENVQREIMNHRSLRHPNIVRFKEVVLTPTHLAIVMEYAAGGELFERICSAGRFSEDEARFFFQQLISGVSYCHSMQICHRDLKLENTLLDGSIAPRLKICDFGYSKSSLLHSQPKSTVGTPAYIAPEVLARKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPRNFRKTITRILSVQYMVPDYVRVSMECRHLLSRIFVANPEQRITIPEIKNHPWFLKNLPIEMTDEYQMSVQMNDINTPSQGLEEIMAIIQEARKPGDGSKFSGQIPGLGSMELDDVDTDDIDVEDSGDFVCAL
The following text describes a protein:
Function:
Serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MGCCNSSPSMEDPPPQNVHQNHGGSDSQITKFSFSDLNKATENFYLKNIVSENGGETSDTVYKGRLHNGGFIAVKKFMNMAWSDSNQFVEEAHRVGKLRHNSVVNLIGYCCDGNERLLVAAFMPNDTLAKRLFHRKNQTMEWEMRLRVAFCVAQALDFCSGGGFTSYNNLNAYSVLFNEDGDACLSCFGLMKEFKDDQRATGSVNSESLIFGFGTLLMNLLSGKQIPPSHAPEMIHGKSVVELIDPNLKGKFSAEEATIIFKLASQCLQYEDIESLNTKDLVTTLETLHTKTNALSYGMLEMAKRQDVSLNQLSTLGDACLKMDLKAIHKILVMAEDDKELVEFSFEEWLEEVKDIQEVRKHGDQAFLEQDFETAIDCYSQLIESRRMVYPSVYARRCLCYLFCNQPDRALKDGMVAQQLFPDWPTAFYLQSVALSQLNMITDSADTLKEATLLEAKRQHQEKES