lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Regulator of mitotic processes which plays a role during gametogenesis and embryogenesis. Together with SKP1, RBX1 and a F-box protein, it forms a SCF complex. The functional specificity of this complex depends of the type of F-box protein. SCF(UFO) is implicated in floral organ development. SCF(TIR1) is involved in auxin signaling pathway. SCF(COI1) regulates responses to jasmonates. SCF(EID1) and SCF(AFR) are implicated in phytochrome A light signaling. SCF(ADO1/ZTL), SCF(ADO2/LKP2), SCF(ADO3/FKF1) are related to the circadian clock. SCF(ORE9) seems to be involved in senescence. SCF(EBF1/EBF2) may regulate ethylene signaling.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, phragmoplast. Note=Mainly nuclear during interphase and preprophase, but also weakly cytoplasmic during interphase. Associated to mitotic spindle during metaphase, and to the phragmoplast during telophase.
Sequence:
MERKTIDLEQGWDYMQTGITKLKRILEGLNEPAFDSEQYMMLYTTIYNMCTQKPPHDYSQQLYDKYREAFEEYINSTVLPALREKHDEFMLRELFKRWSNHKVMVRWLSRFFYYLDRYFIARRSLPPLNEVGLTCFRDLVYNELHSKVKQAVIALVDKEREGEQIDRALLKNVLDIYVEIGMGQMERYEEDFESFMLQDTSSYYSRKASSWIQEDSCPDYMLKSEECLKKERERVAHYLHSSSEPKLVEKVQHELLVVFASQLLEKEHSGCRALLRDDKVDDLSRMYRLYHKILRGLEPVANIFKQHVTAEGNALVQQAEDTATNQVANTASVQEQVLIRKVIELHDKYMVYVTECFQNHTLFHKALKEAFEIFCNKTVAGSSSAELLATFCDNILKKGGSEKLSDEAIEDTLEKVVKLLAYISDKDLFAEFYRKKLARRLLFDRSANDDHERSILTKLKQQCGGQFTSKMEGMVTDLTLARENQNSFEDYLGSNPAANPGIDLTVTVLTTGFWPSYKSFDINLPSEMIKCVEVFKGFYETKTKHRKLTWIYSLGTCHINGKFDQKAIELIVSTYQAAVLLLFNTTDKLSYTEILAQLNLSHEDLVRLLHSLSCAKYKILLKEPNTKTVSQNDAFEFNSKFTDRMRRIKIPLPPVDERKKVVEDVDKDRRYAIDAAIVRIMKSRKVLGHQQLVSECVEQLSRMFKPDIKAIKKRMEDLITRDYLERDKENPNMFRYLA
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
MSTHSGDSTKQQHYRSSDPYSGRRPIPTIPKFFRDRKQRAEKKEEQQREQTENEKLFDPITQRDVEINDVHFDYAKTYDDPSFTVPNQSIQGSSLPSEKPYLSSNQPTNVYKQHQDDLAPPEADNQITRDVPISDEKTNILFFPSPSIDLSYVSKEVKQKTGQYSLFAYIFSLVISWFFTHSIIISAVLPLAISSCMYLWMQNIYAVAKDAEWGAEQKRGEYARLNLIPESAEWMNHLLEKVWPLINPEMFSSVADQIEDVMQASIPSFVENVRVASLDQGSHPVRVVSIRSLPSGEASESFSEKQASEAEHKDEPEQQRKQFYNFELCLAYHAKPVEDATSTSARASNLHLRIVFYPGIKGTVGFPLPIWVEIKGFVARIRFRCELMPEVPFLKNVTFSLMGLPELNVSAVPVAEGGVNIFGLPLISKFVNDAISAAANEYVSPKSMTIDLSKTLLGDDIKKEVNALGVIFVHINRAEDLSKQDVNGLSDAYITVGFHKFGKPLYCTRVVKQDLNPIWNEYAFIPVFPDQVKAGEKISIELWDSDRFSPDDVVGRTKIGLHLLIQDSGKMHERCDTLTGISEDTSLPGRVFYEIGYFPRAEFKPSLKTSGHDITIPRSMRDDPAFQNPHGSLDNKEEEAAVTTAPDEEYPSGILSFTVHQAVNLQMNHPTGTFGNVSGNYNTSPAQSVGDVTAEEGSELPSSYVCVDLDDTLVYKTRTKVFTSNPIYNAGSEKFVKDWRNAMLCFTVRDFKLREHDSILGVVNIPLATTLTTSSQLTKWYPIQGGIGFGSVRISILFRSMKLKIPRNLLGWDIGTLEFMDRQIVAEGTGSVSDVSFSSIRVNIAGVKITAKSSTSNSSSTAEYHVRSRHAVIPVNNRYRSAVVFEFRKQLQRKHNVFAMVWLVDLEDNVEQNIRVPIFTSSKPAHVLQNMIDFDHPDKESEFKIIGYLSTRICFHRGLDDSHEQLVDNDDEAAIFETYRCLKSMGLRRGYVKDMKNPLADQRASLDESRETTTASSKFESDDSVDTEDEETTTDRTPIECTQTVSMVDPNVNGDIQGRNSLGTMNSNERNLEQEFISLGYASKNRPKAHAQEGTNQPGASENVEPVLADDSDAVTIHSNISSDDQKRKLVNADDRELEKRLHRGPYNSKIVRTGEWVKDGAKMGWRNLRRKFALNGRQPDVETEISK
The following text describes a protein:
Function:
Involved in the biosynthesis of L-tartarate from L-ascorbate. Catalyzes the NAD(P)H-dependent reduction of 2-dehydro-L-idonate (2-keto-L-gulonate) to L-idonate. Can also reduce hydroxypyruvate to glycerate, glyoxylate to glycolate and pyruvate to D-lactate. Prefers NADPH to NADH as proton donor.
Sequence:
MESIGVLLTCPMNPYLEQELDKRFKLFRFWDFPSANDLFREHSNSIRAVVGNSFIGADAQMIEALPKMEIVSSFSVGLDKIDLVRCKEKGIRVTNTPDVLTEDVADLALALILATLRRICESDRYVRSGSWKKGDFKLTTKFTGKSVGIIGLGRIGSAIAKRAEGFSCPISYHSRTEKPGTNYKYYPSVVELASNCQILVVACALTPETRHIINREVINALGPKGVVINIGRGLHVDEPELVSALVEGRLGGAGLDVFENEPNVPEELLAMDNVVLLPHVGSGTVETRKDMADLVLGNLEAHFLNKPLLTPVV
The following text describes a protein:
Function:
Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export. Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis. May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta. Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8. May be involved in regulation of pre-mRNA splicing; (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters; (Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses; (Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity.
Subcellular Localization:
Nucleus. Nucleus matrix. Nucleus speckle. Nucleus, PML body. Cytoplasm. Note=Colocalizes with PRPF40A in the nuclear matrix. Nuclear at steady state but shuttles between the nucleus and cytoplasm. The shuttling property has been questioned. Colocalizes with EBNA-LP in PML bodies.
Sequence:
MSYTGFVQGSETTLQSTYSDTSAQPTCDYGYGTWNSGTNRGYEGYGYGYGYGQDNTTNYGYGMATSHSWEMPSSDTNANTSASGSASADSVLSRINQRLDMVPHLETDMMQGGVYGSGGERYDSYESCDSRAVLSERDLYRSGYDYSELDPEMEMAYEGQYDAYRDQFRMRGNDTFGPRAQGWARDARSGRPMASGYGRMWEDPMGARGQCMSGASRLPSLFSQNIIPEYGMFQGMRGGGAFPGGSRFGFGFGNGMKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYVGTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIQQIYRDQDLTQEIAMEHFVKKVEAAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGGGAP
The following text describes a protein:
Function:
Could possibly oxidize fatty acids using specific components.
Sequence:
MAAVTPTVPEFVNVVVSDGSQDAGLAMLLLSRPPTNAMTRQVYREVVAAANELGRRDDVAAVILYGGHEIFSAGDDMPELRTLSAQEADTAARIRQQAVDAVAAIPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATEILAGLIPSGDGMARLTRAAGPSRAKELVFSGRFFDAEEALALGLIDDMVAPDDVYDAAAAWARRFLDGPPHALAAAKAGISDVYELAPAERIAAERRRYVEVFAAGQGGGSKGDRGGR
The following text describes a protein:
Function:
Transcription factor. Binds to regulatory elements and regulates transcription of target genes, including the potassium channel accessory subunit mps-2. Negatively regulates transcription of mps-2, thereby modulating age-dependent memory decline. In concert with nuclear hormone receptor nhr-49, involved in regulating target genes with roles in sphingolipid breakdown and lipid remodeling. Plays a role in modulating mitochondrial morphology and function.
Subcellular Localization:
Nucleus.
Sequence:
MPPINEPTATTTSASSVWQGMTQLKSQVDLINIARGILSTPATTSTSCLDIQNSTPIIGSLASGKSQTPILTATMTPQIGLTGLGSLTSLPPELLLQFARLDGFNLLPAVGSPAIPSSSSCSEPSTSQASTVVSAPTLPPPSPLTSLPQKPAPLMPSGHVTTVDQQNRQQHQQQQRQQQQAQQQNSMARKYSMDTIQHHTMQHPHQLQYIPNHFMTASTDVFAAMDMSQKQSSPPGIFKIVAAKNEPSSSSNSQPGTPAMGDRRAVPACAICGTDSTGIHFGVDACAACSAFFRRTVVLNKDYSCNKGGKCTVVKDGSAGQKCRACRFRKCISSGMDKNSVQHRRDAIGKYSAGVKRELSPDAEFEPSAKVSTVSEPSTSSGPSGGFNQNVSSPAGIPRVPSTLRTTQASTCMNSACGQKSVLHELICRQNFLTEQRQLFYAGCLGDWFRKPSSIENQTLSELTDFSSCMFHLWKIEPRLAADFMNRNRYLDPLPIVEKLKIYRNFVIMRQSVEEPYLTWRHGGLEKRWFVMPNNTYIDFNNIAKYFENGALKDLKLDYETTTNLFLPSFTHAMDTIGEKMKKNNITETELTILLGLVLLDPGIYGIHESTRKFLKRIRDQLIHDVYMYYEDEMSHLYDPEIRMADIFMLVAAIKIHSIKTSENMHMLRVFDLIPADACFNQMLDVESVNVSPDGQKDSEAEQGPSPVSVPEAARGSYQDDDMPPVLEKNCDL
The following text describes a protein:
Function:
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Miscellaneous:
MISCELLANEOUS: Present with 556 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTKDAVNLDAYTVSFMPFYTEYQGPTEEFKDYKFEDTIYFRGKELKREKSATPSSSDNTTSNTFSNGAILSGNTITGKIVSVNNYEREGTDRNELARLQELISLIDVINQ
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular Localization:
Chromosome. Cytoplasm. Nucleus.
Sequence:
KAALKSQGPLCILEHFDTAYSILQHFQTADSAVKADTLDILLKVVSGLSASLPALLDSSSLSPADRKLQLNTVKMGVFLLCKLAEGLESDSSRHSIITAPSKGGKKSRTVNADAPFQWDTERDHVLQALTQLLQLDIRTLWSLSLVEEEFTSCVTRCCYKLLENPAINQVKYKSTREAIIHLLGLLVKKYNHLLGASVKVIQLLQHFEHLSSVFAQAMSVWGSEYGVKAIVGEVIREIGQKSSEELSREGSGVRSYAAFLSELGTLVPEAMVPNISVLLQHLEGECYSMRLAVCEVLGEILVRVLHGDQLSETSRAARDQFLDTLQEHVHDANAFVRSRVLQVFTRVVQSKALPLVRYREVLTLAVGRLIDKSVNVCKNAIQLLAAFIANNPYSCKLSSVDLKAPLEKEVAKLKELKEKEREKAPVAVIEAWEVWQAMEPELLQTVQAELDRRSQEDETEEQNETEEEIQPGGSPRDTAVRIAQLLQSNKYRQAVGLTLKGLSAFPESDYFSADSPLTADGIMGTLGRIFKAFCREKDKLFHTAGRGSEEDSGKQEPVTVVADKKEEGSEEEREEASSELKKQEMLVQYLRDTESFSLQIEEAISLITSMLYWKTTSVVQEAIQFCVTVCEFGVSQSLNGVRRMLPLVWSPDTAVREATVEAYKRLYLRPPGDTLRAKAQTLVHNLSVLMVDASLGTIQCLEEIVLEFFQKSELQSTVIQVLWERFTGKTACSGLERRAAVLLLGMAARAEKEVVLSNLDTLVSVALGEKVMEDFLLARDACIAVSKITDKNKRKDGRPFRLPQDHQLFTALTDAITAGVLLNDAYWVSFMEQAVSLIYQLSESPDKTCAHILRSCTKRLLDEITQFVSDSLSLLLSVQCGALAQLLSLAGSVAFQQLEHLERSVSGELRRRRMEKEEKQSAPDRTRHSSNETTVEEEMGLTGASAEDTEAELIRKICETELLHEETVLTPFLPLMVKVCSNPGRYSHPQLSTAACLALAKYMMISSSVCDSNLRLLFTMLEKASLPSVRSNTIIALGDLTIRFPNLIEPWTPHLYARLSDQCPSVRLTALTVLTHLVLKDMVKVKGQVSEMALLLIDPESKISSLALNFFNELAGKDNAIYNLLPDIISRLSDPERGIAEEDFQTIMKQLFSYITKEKQTESLVEKLCQRFRTAKSERQWRDLSHCLSLLSLSERGFKKLQECWECYSDKLSEEGVYQGLLALVGKLRRAAKPEVKAQVEEFEKRLTAVHTRGLENVETEEGDGGSQTTKTPAATRKTDRKPTRGKSRTLTAQNDDKDDFCTPKTKTRRVPRKKPTISFSSDEEEEESAAELSENETPKVTTPILRSARRSRTRR
The following text describes a protein:
Function:
Single strand-specific metallo-endoribonuclease involved in rRNA maturation.
Sequence:
MSLVIKNLQRVVPIRRVPLRRKMDLVRSILGVKKFDLGIICVDNKTIQNINRIYRNKNVPTDVLSFSFHENLKAGEFPQPHSPDDYNLGDIFLGVEYILQHCRESEDYCDVLTVTATHGLCHLLGFTHSSKAEWQKMYNQEKLVLEELSRYTGARLQPLSRGLY
The following text describes a protein:
Function:
Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis. May play a role in the cell cycle regulation (By similarity). Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity.
Subcellular Localization:
Nucleus.
Sequence:
MLNFGASLQQASEGKMELISEKSKEGAHPWDKAEQSDFEAVEALMSMSCDWKSHFKKYLENRPVTPVSDTSEEDSLLPGTPDLQTVPAFCLTPPYSPSDFEPSQGSNLTAPAPPTGHFRSLSDAAKPPSIAPFKEEEKSPLAAPPLPKAQATSVIRHTADAQLCNHQSCPVKAASILNYQDNSFRRRTHINVEATRKNIPCAAVSPNRPKPEPSTAANGAEKAGTAPYDFAVPSSETVICRSSQPAPTSPVQKSVLMSSPTVSTGGVPPLPVICQMVPLPANNSLVTTVVPSSPPSQPPAVCSPVLFMGTQVPKGTVMFVVPQPVVQSPKPPVVSPNGTRLSPIAPAPGFSPSAARVTPQIDSSRVRSHICSHPGCGKTYFKSSHLKAHVRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHTGEKKFACPMCDRRFMRSDHLTKHARRHLSAKKLPNWQMEVSKLNDIALPPATASAQ
The following text describes a protein:
Function:
Involved in the early part of the secretory pathway.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein.
Sequence:
SALFNFQSLLTITLLLICTCAYIRSLTPSLLDRNKTGFLGLFWKSARIGERKSQYIAAACVLMAVNILFWS
The following text describes a protein:
Function:
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MLSKTLQRVRSLSVFDVLYYILKFVLSICTAYMHWNLLKLFLNNDMPGIVVLTGSMVPGFMRGDISAIKSTNHNLGIEVGDIVGYSLMHRAIPISHRVTERRVIIDNDFPCDVNSTVVDATGVVLHHGPSSIAKAANPPALPSPCRRLAFITKGDANKVKDTFLYTTGRVYLEPYELVGKMLINLPGLGYMTILLQEHKWAKVLLFGMIILMAISGREE
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MLAVFGEPPRMVTQYMALFDNVIHKLRAPKFYEIVSEELGKDCLVIFQGLVQHGRLSVNDMIAGYADIEGSSENVGRESFTKLVNARFVEHCPAPDPHLEPHVVDEKGKKKKTEEKGTEYSKNLPHFHVEEPPLDQRVLAEAAPMESMRFFLEMDDHSEEKGNETTTSVKSGQKVGMRKQDEGELDADKKKEVLWRVNVEEFLRRLRHKACIAHVKSKINEEAAIVLSAMLELSKQSESGLKAEKSEYLSINAIYDEVIKKEGGLGMDFERVRSLLDQLGCETLSSGMDESYCIDFNLFILVQISDCTFVEKKATIAILYKLWKDDFLQMEHVKTSTAKQSDFRLWKMRNAIDFPREGFKINKMGKIKRKRLPKDKLVGESNTKYVRWANVTRILESCLMDLDDAIMLFHHF
The following text describes a protein:
Function:
Multifunctional protein which displays endonuclease and helicase activities required for initiating and directing viral DNA replication. Also plays a role in viral packaging and transactivation of several promoters. Binds site-specifically to 2-3 approximate tandem copies within the origins of replication (Ori), unwinds this hairpin region and nicks one DNA strand thereby initiating the rolling circle replication (RCR).
Subcellular Localization:
Host nucleus.
Domain:
In the N-terminus, the endonuclease region is involved in binding to the origin of replication. In the middle, there are the ATPase and helicase activities (By similarity). The C-terminus probably contains a transactivation domain (By similarity).
Sequence:
MAQAQIDEQRRLQDLYVQLKKEINDGEGVAWLFQQKTYTDKDNKPTKATPPLRTTSSDLRLAFDSIEENLTASNEHLTNNEINFCKLTLGKTLLLIDKHVKSHRWDSNKVNLIWQIEKGKTQQFHIHCCLGYFDKNEDPKDVQKSLGWFMKRLNKDLAVIYSNHHCDIQDIKDPEDRAKNLKVWIEDGPTKPYKYFNKQTKQDYNKPVHLRDYTFIYLFNKDKINTDSMDGYFAAGNGGIVDNLTNKERKTLRKMYLDEQSSDIMDANIDWEDGQDAPKVTDQTDSATTKTGTSLIWKSCATKVTSKKEVANPVQQPSKKLYSAQSTLDALFNVGCFTPEDMIIKQSDKYLELSLEPNGPQKINTLLHMNQVKTSTMITAFDCIIKFNEEEDDKPLLATIKDMGLNEQYLKKVLCTILTKQGGKRGCIWFYGPGGTGKTLLASLICKATVNYGMVTTSNPNFPWTDCGNRNIIWAEECGNFGNWVEDFKAITGGGDVKVDTKNKQPQSIKGCVIVTSNTNITKVTVGCVETNAHAEPLKQRMIKIRCMKTINPKTKITPGMLKRWLNTWDRQPIQLSHEMPELYLGKCRW
The following text describes a protein:
Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Subcellular Localization:
Golgi apparatus. Secreted.
Sequence:
MKLVYTVASAFLVVLIAQSAYASEKLSAQDYAYNSTCLNHLRSHIKRELQAAVTYLAMGAWANHYSVQRPGLANFFFDSASEEREHGLKLLGYLRMRGHNDLDILPSSLEPLNGKYEWENSLSALRQALKMEKDVTESIKKIIDYCADAEDHQLADYLTGDFMEEQLKGQRNVAGLANTLQGVLRKQPRLGEWIFDNNLSKSMAV
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MAAPYAKNRGSKRKGKKSKSASMKDLFSNVEADYPVPRRTKGTAILEHGAWKPVRVDQSLCSSDDLSGFVGLEELTDYELCQEGKQKQQKTTKKQKKKGQEQKSKGHDEENLEGDTTKPKKEMKVLGIEEKNAKLKIQKPAKKLKRKAQVDEEGEALKMSSSQSDEGSEDNTNINKEVTEPLKKKQRTELSSQKDGDCKDESVDEPGTDAATEGVTKKSRKERRNERRKQRLESLKRQREEKRERKKQERKMPLAQGHSCKPQSVAKKSVDADMTPWTPLFVPDVVLRGLADQGFTQPTPIQAQTIPQAIQAHKDVVGAAETGSGKTLAFGIPILHRILEWKERNLQTEEGDLGNKDEEVVDDAADDDDDQEMEVPDEEDDKVEEEEEDDEEELVLDNAGLGCVHVEDDITLPPELEALQEAPPLSAPTPQKVVSPLLALVLTPTRELAVQVANHIKAAAKYTNVKVAVLVGGMAPQKQKRVLDRQPEIIVATPGRLWEMVEQSHPHLSDLNQLQCLVIDEADRMVEKGHFAELGNLLDKINGEGRNLRRQTFVFSATLTMVHSGPQRKIMKKKFKMDKDKKLGQLMDRVGIRSKPLVVDLSRQQGTVDTLTEARITCSTEEKDIYLYYFLLQYPGRTLVFANSIDCIRRLTSLLGLLQKSPLPLHANMHQKQRLKNLERFSANENGLLLATDVAARGLDIPDVQHVIHYQVPRTSETYVHRSGRTARAQKEGLTLLLTGPEDAQYYKRICKTLGKDEDLPVFPTEPQHLAAVKARVAAGRRIDVEEHRYMKKKHHNDWFLQQAKEMDIELDEDEVLHDLGDTQEQDKVLSELKDMKKSLSKMLKAPIFPKGFSGLYPIQYGQPNLPRLPNAVAATLAVNNSRKKKHKP
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MEFRARPRLAAAQGVARPAQSASPPYSSSAPSNTSSSQVNLTSLFCFLLAFRVSNALATRTFFQPDEHYQTTEIAHRLVFGYGFKTWEWVSAYAVDAPSNTSYLTAAVQNLFNGPVRSILHPLLFVPGYALLKSTGLDKSYLLVLFPRLQQAIVAAIGDFYTFRLAHRIGGPALGWLAMLVGTCNLYALFTATRTFSNSTEAAVTAAALFYWPFVPFYSLRFDVATFSSAEERSMLMQLQGPACVWHQMRPQQKRSQEDLDLDIKQISRIIYDRTLRKSVMLAAFACLLRPTNGMLWMYLTAELFVRQVRSLRSNTSDRSAEDQQGSVLPLLELVGEASSFVATLAIIGFASVGLALIVDTTYDYLANQVGESARILPALSLVSFVHKNVVANLSIFYGTNPCHWYISQGLPVLCTIWLPATLFGLLKAFQERNQALAADAKRSLARLVCVTVAVYSLLGHKEFRFLQPLLPALTILAATGLESSYAKRRSRKAVPMLTDHQDGPLKHMWRALNLLPFWLRAVLLTLQPIAAVYLTTIHAVGQEQVPFELGRMFRQQQLTSESSANQVEFGSGFGRIHNLGFLMPCHSTPWATHLHDKQLVDRSWFIQCPPPPSRSLMTREQQTVEYWDQSDFFYHDPIKYLVDRFPYNVNTDYPASPKSQQQGGGHPWDKGWRHSWPSHLVVFESLLKEGTRKPGHTRTLKNLLSLKGYREVARYWNTPKHEDPRRDGDIVVLAYKGPKSHR
The following text describes a protein:
Function:
Probably part of an ABC transporter complex involved in arginine transport (By similarity). Binds arginine (By similarity). Interacts with host epithelial cells, suggesting a role in host-cell adhesion during infection.
Miscellaneous:
MISCELLANEOUS: Does not induce neutralizing antibodies; MISCELLANEOUS: This protein, although well conserved among chlamydial species, shows species-specific immunogenicity.
Subcellular Localization:
Secreted. Cell surface.
Domain:
Contains two domains, D1 and D2, which are both exposed on the surface and bind to epithelial cells.
Sequence:
MCIKRKKTWIAFLAVVCSFCLTGCLKEGGDSNSEKFIVGTNATYPPFEFVDKRGEVVGFDIDLAREISNKLGKTLDVREFSFDALILNLKQHRIDAVITGMSITPSRLKEILMIPYYGEEIKHLVLVFKGENKHPLPLTQYRSVAVQTGTYQEAYLQSLSEVHIRSFDSTLEVLMEVMHGKSPVAVLEPSIAQVVLKDFPALSTATIDLPEDQWVLGYGIGVASDRPALALKIEAAVQEIRKEGVLAELEQKWGLNN
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MLISVFFLLQQPYLHESRHVHALKRPRGSGGRFLNTKKLLQESEQAAAKEQERDKSVQQAMRQTCLDSKLICYSTTKTVVAQPLLALTSHLFPKVLISSDTLNSCFRVSQQLGLTELCLFMVSPMTCMEVGTCTISLSISETLDLW
The following text describes a protein:
Function:
Ribonucleoside-diphosphate reductase holoenzyme that provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). The N-terminal region confers antiapoptotic activity in differentiated cells such as neurons and is important for viral reactivation to increase neural survivability. Prevents host necroptosis by targeting host RIPK1 and RIPK3, thereby hampering the formation of necroptotic RIPK1-RIPK3 complexes. May form hetero-amyloid structures with host proteins RIPK3 or ZBP1, thereby preventing RIPK3- and ZBP1-mediated necroptosis (By similarity). In addition, inhibits extrinsic apoptosis by targeting host CASP8.
Subcellular Localization:
Host cell membrane. Host endosome membrane. Note=Associates with the host cytoskeleton.
Domain:
Contains an alpha-crystallin domain homologous to small heat-shock proteins; The RIP homotypic interaction motif/RHIM may drive self-assembly into homomeric amyloid structures and mediates interaction with the RHIM motif of host proteins RIPK3 and ZBP1 to form heteromeric amyloid structures.
Sequence:
MANRPAASALAGARSPSERQEPREPEVAPPGGDHVFCRKVSGVMVLSSDPPGPAAYRISDSSFVQCGSNCSMIIDGDVARGHLRDLEGATSTGAFVAISNVAAGGDGRTAVVALGGTSGPSATTSVGTQTSGEFLHGNPRTPEPQGPQAVPPPPPPPFPWGHECCARRDARGGAEKDVGAAESWSDGPSSDSETEDSDSSDEDTGSETLSRSSSIWAAGATDDDDSDSDSRSDDSVQPDVVVRRRWSDGPAPVAFPKPRRPGDSPGNPGLGAGTGPGSATDPRASADSDSAAHAAAPQADVAPVLDSQPTVGTDPGYPVPLELTPENAEAVARFLGDAVDREPALMLEYFCRCAREESKRVPPRTFGSAPRLTEDDFGLLNYALAEMRRLCLDLPPVPPNAYTPYHLREYATRLVNGFKPLVRRSARLYRILGVLVHLRIRTREASFEEWMRSKEVDLDFGLTERLREHEAQLMILAQALNPYDCLIHSTPNTLVERGLQSALKYEEFYLKRFGGHYMESVFQMYTRIAGFLACRATRGMRHIALGRQGSWWEMFKFFFHRLYDHQIVPSTPAMLNLGTRNYYTSSCYLVNPQATTNQATLRAITGNVSAILARNGGIGLCMQAFNDASPGTASIMPALKVLDSLVAAHNKQSTRPTGACVYLEPWHSDVRAVLRMKGVLAGEEAQRCDNIFSALWMPDLFFKRLIRHLDGEKNVTWSLFDRDTSMSLADFHGEEFEKLYEHLEAMGFGETIPIQDLAYAIVRSAATTGSPFIMFKDAVNRHYIYDTQGAAIAGSNLCTEIVHPASKRSSGVCNLGSVNLARCVSRQTFDFGRLRDAVQACVLMVNIMIDSTLQPTPQCTRGNDNLRSMGIGMQGLHTACLKMGLDLESAEFRDLNTHIAEVMLLAAMKTSNALCVRGARPFSHFKRSMYRAGRFHWERFSNASPRYEGEWEMLRQSMMKHGLRNSQFIALMPTAASAQISDVSEGFAPLFTNLFSKVTRDGETLRPNTLLLKELERTFGGKRLLDAMDGLEAKQWSVAQALPCLDPAHPLRRFKTAFDYDQELLIDLCADRAPYVDHSQSMTLYVTEKADGTLPASTLVRLLVHAYKRGLKTGMYYCKVRKATNSGVFAGDDNIVCTSCAL
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
VQRPGLDEFLDQMSALYEIVLFTAGPQELAEQWVTAIDKGRFAFILYGNSCVSPKVGVNHKILKDLGRDMARVVVVDDTPSTYKYNQENALPITPFYRGDDTDQELLALIPFLASIAHSEDL
The following text describes a protein:
Function:
Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate, in vitro. May regulate DNA damage and repair by regulating HIF1A degradation via chaperone-mediated autophagy (CMA).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Mainly located in the cytoplasm.
Sequence:
MAETESCTFHVPSLEEICSILKSGLLKNFADVNVIVTECPDLTKEPFEFPVKGLCGKSRIADVGGVPYLVPMPRLDKVYNVNTVAKKIGLPGAYILGAGATSHRSLGMNAELIFSVQAESTSTLAVNKSYVASVNPGDGSCLLEKYRDRNNDNDFGLLSNLYACEGKPGKVIEVSVKRRIGQDNFVSCMRKSLKEHYGENAVGMGGTFLIKQGKAKLHVMPREYSACPLNTDEDVNGWLKFYDMTAPLICQSVFVSHDPGYDLRLEHTHCYSHHGEGGHYHYDTTPDTVEYLGYFHPAEFLYRIDKPSATHLVGRD
The following text describes a protein:
Function:
Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.
Sequence:
MNSSTNENTELVSSNYHKLESPTQLQSLLGADLKRLSILYFRAEWAEICRTADPFIRSLSQKWKEPLFLEIEAESLPEVAESFEVSSVPCFVILRGHQLLSRIIGAELTQLESDVEKFVKASQNQQSNGKYEVLSETTQKPKPPSSAPNVNKLQAGATSNEDETEEQLFSRCKDIMQQSKVVVFMKGDPRTPRCGFSQQTVKILQDLNIEFTTFDILTDEKVRQGMKKLNSWPTFPQIIIKGELVGGLDILKEMIQNNGKEKTELEELLES
The following text describes a protein:
Function:
Acts as a tetrameric transcription processivity factor that binds in a competitive manner to RNA and the phosphoprotein (P) to prevent premature termination during transcription. Transcription anti-terminator that enhances readthrough of intergenic junctions during viral transcription. Preferentially binds to poly(A)-rich sequences. Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding. Also, can activate host NF-kappa-B through association with host RELA.
Subcellular Localization:
Virion. Host cytoplasm. Host nucleus. Note=Localizes in cytoplasmic inclusion bodies substructures called inclusion bodies associated granules (IBAGs). Forms a layer between the matrix and nucleocapsid.
Domain:
Contains a zinc-finger domain on its N-terminus essential for its anti-termination function. Contains an oligomerization domain. The central globular core is responsible for binding to RNA and phosphoprotein.
Sequence:
MSRRNPCKFEIRGHCLNGKRCHFSHNYFEWPPHALLVRQNFMLNRILKSMDKSIDTLSEISGAAELDRTEEYALGVVGVLESYIGSINNITKQSACVAMSKLLTELNSDDIKKLRDNEELNSPKIRVYNTVISYIESNRKNNKQTIHLLKRLPADVLKKTIKNTLDIHKSITINNPKESTVSDTNDHAKNNDTT