lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Adapter protein involved in endocytic recycling of synaptic vesicles membranes. May act by mediating the retrieval of synaptotagmin protein Syt from the plasma membrane, thereby facilitating the internalization of multiple synaptic vesicles from the plasma membrane.
Miscellaneous:
MISCELLANEOUS: StnA, which is involved in the same pathway, is derived from the same bicistronic transcript that encodes these two different proteins.
Subcellular Localization:
Cytoplasm. Synapse. Note=Colocalizes with synaptic vesicle pools. Colocalizes with the endocytic network within synaptic boutons.
Domain:
The Asn-Pro-Phe (NPF) motifs, which are found in proteins involved in the endocytic pathway, are known to interact with the EH domain.
Sequence:
MANPFLMDEDLDGCDAAANPFLMQSEPEPSSDNPFMAATVASNPFAFGADDLELGAEPEAEATHDNDLDPAMSFFGTTIEAEDDTLSLKSGAEEEDEGKKPPQSQPQLQSHAHPHPPPPRPLVPPQSTQDLISTVSSQLDETSSELLGRIPATRSPSPVSMRDLHSPSPTPDSGLADLLDVSVDSGSSAHTQGIEADLISGVAGGVRLDNPFAVPTAVPNIQAAVPLPATPIKQPPRPPPPRPAPPRPAPPGQAAPQRPPPPLAAVNPPPAAPEADDLLDMFGTTACKPAKPPPPKSKEDILSLFEQPHVPLSQPASKPDLLHDDLDETIGEGEPPEQEEPDTEQSNEISSRDEPVFTSLLIRPDESTHDITSQPQAATGLERQVNNMAAPSGTASTQRATTPDIEITTVEDLPRSDDEDEPEAMQEPETETKPQIEPDTEPEIVSEHSPPTERLVTQAALVDGELIAAEPEPEEMDTGLDFPLASSGQLSANPFASPDEEEPNFAPMPAAVANIFAVNDPDSQMETPKAPSHTANIFASDPDEFDAFSAKFDSVKKDNISIMDGFGGSGAITPTGGDAWGGSAFGSTTISANACGDTNSADDGFGNDDDDFYAMQAPARADSVESVDKDFSVVIRPMAEETSGVAPQLAPPPPPARGVNQAQTTSLPGLTVNPFEDVSGFPAPGLPPTDGTAIKRTDSQDTPQTPLYDEDVSQPLEEFPRLHYIGPGWEMQLRQPNKKKITGQRFWKKIVVRLVVQNDVPVVQLLNQAGDKQPFQELPLQPSYSVSEIGAQQYDQFGKIFTMKLQYIFYKERPGVRPGQVTKAERITNKLTKFAQYAIAGDYEGVKEFGSDLKKLGLPVEHAPQSSQLFKIGSMNYEDMKQFSVCIEEALFKIPALRERALTYKMEEVQVTAVDEITVEQDFEGKILKQIARVRLFFLAFLTGMPTIELGVNDMWRQGKEVVGRHDIIPVATEEWIRLEAVEFHSVVNQKEYERTRTIKFQPPDANYIELLRFRVRPPKNRELPLQLKATWCVSGNKVELRADILVPGFTSRKLGQIPCEDVSVRFPIPECWIYLFRVEKHFRYGSVKSAHRRTGKIKGIERILGAVDTLQESLIEVTSGQAKYEHHHRAIVWRCPRLPKEGQGAYTTHQLVCRMALTSYDQIPSELAPYAFVEFTMPATQVSHTTVRSVSVQDSDGDEPPEKYVRYLARHEYKVGIETTHGESTNAYLAATRPIREEPPTTATKPTASPVAPSDSDTDSN
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MTNEYDGTNTFPRFSLGGISEIVVRIKEGPGSLGQPLYRLRGEDADGDVLSFGAQGPEGPELLRFDRVSATEADVFLRHELDREVKDSHTVVLTLTDGRLPEGQYITQTMLVIVDDVNDNEPVFKQYRTTVTVSEDAAPQVIDTVEAIDRDQGPFGQVIYQLQDRANSGPRHTATAVVLVKVDDVEDQPPVFTQVPPVTRISEDLPLNSMVLTVKAMDGDRGVNNPISYSILSGGDGLFAIDRETGVVSVKGRLDREATENRNGAFILLVQAQEVSGSARPLGPTARTEVTILLTDVNDEEPTFRSRHYVAEVNENAQLNVPVNFVGDSIAEVYDHDQGSNGTFQLRLEKDNGVFEVTPSIGVNEVSFMIRVKNPDHLDYERVKLVKFKIVAQEMVASQPKTSTADVTVHIKDANDNFPVFREDSYRSVIPENAAAGTVVAVVRVSALFRLNGWCGVSRLKLDPETGKVVMATSEHGLDRETTPEYLLTVEARDENGRGNRNTVQLHLVLEDVNDNAPGFVLPSYEARIRENAADFRTPFVVRAVDADQAGTENCQVRYQIVRGDPDNNFTIDEAKGRIKPRQPLDFERIAQPRGDVRTFNLVVRAYDLGRPSLSSNVSVVVYVQDVNDHSPVFPSDFVAKSIPEDVQEGTAIVKVLAEDQDHSPSNSKVVYRIQNGAQDKFVIDALTGVISVAPGANLDPDRTFPKSVLYSLQILALDGGLGEQQRSSMVTVNISIVDVNNKAPRFDDPGTVELVENSVPGHTVAIVRATDQDDRPMLRYSLCRASSEARNEDGALVSEFDVQQTFEIHALEGKLMVKNNVDREKMESIKVCVRVEDMAAATPHQTATATLSVKVMDVNDNKPTFKKSFYRQTVTENSVVGAPIVTARAVDADKNHTVTYSLEGKAEYLALINIDRRTAWDNYEAGFGTDESRRTFKQVSVRVVDVNDESPVFVRQTQCAQVSEFHRAHETVFLASATDGDDPTSPNSKITFTLQSGFDADLFEVETLPDNTARVANRYSLRGRVGNATVALKAQDQGLPPRSSVQRFTVCVSDVNDHSPVFIRPPQNHTIRIPENATLGTVVVEVGAEDGDFGANAEVRYRLKDLPNNHWKTFRLDEITGIITLRLPLDRETQKVYELRVEAFDLGQPTSLSSDLDLTVFVTDVNDYAPEFTEDVVSLTFTENMKPGAESYKLINTIDRDDDLSILKPIPCYYIVGGNERGRFSLDLFTHQLSASEVLDREEESNYTLLVRASDDCFHEPRPVARFDSRDNTLLQVQITVLDVNDNPPRFVSPVFTGGVTMEADFGVVFMAVRAVDLDDGINSLVSYYLVGEIRRTLSEGLESLTGPPFLINHRTGELSLNFYPQRGMKGYFDLTVVANDTQGLQDSARVFVSTVPVDPPRLRDSCPRLVFPTTLSPTGSIRTRTAHMLIDKNIEFLDKLFKEFNVLYSEPADALSDAEREEDQMRTWLIGLSVFLSVMLALVISLCLAQRSRYERQLKAATATAFGSRDSALNRVDVPNTNQHSVEGSNPIWMHSYDNDWYKEDEETRNAQSKRGSPRRQLRKSTVYVSHTPITAPVALTSNRPVDSNSLDENAVAETSGSTSSSSDSHRQSQDREFDSAQLCSEVYVLSNGTVQNISMPVGSTDLLCPEVAERNNLNRYNKNGCPYASVFLGKMGTPNRAGKLEVSEL
The following text describes a protein:
Function:
Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis.
Subcellular Localization:
Cytoplasm.
Domain:
The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors.
Sequence:
MKCKSWSNKINNYVVRKIKSIKINGTQQQLQLPGSGASGIAAAAVITVASDCGENCSSNGTEHQQHFNIATTTATSATEATMPAMAKEKASATVSLGESNFRDINLKDLAVVVEAASRLHHQQNVCGCGAVSSTENNNNSRYGSSKYLTNGHTSPLAAAVASNSSSVATTPHCRMLHNCSLQQYQNDIRQQTEILDMLRQQHQQGYQSQQQQQQPQQQQEQQQQQEQSQQQQQLQNPAPRRSPNDFIFGRYIGEGSYSIVYLAVDIHSRREYAIKVCEKRLILRERKQDYIKREREVMHQMTNVPGFVNLSCTFQDQRSLYFVMTYARKGDMLPYINRVGSFDVACTRHYAAELLLACEHMHRRNVVHRDLKPENILLDEDMHTLIADFGSAKVMTAHERALATEHCSEQRRSNSDEDDEDSDRLENEDEDFYDRDSEELDDGDDEQQQEEMDSPRHRQRRYNRHRKASFVGTAQYVSPEVLQNGPITPAADLWALGCIVYQMIAGLPPFRGSNDYVIFKEILDCAVDFPQGFDKDAEDLVRKLLRVDPRDRLGAQDEFGYYESIRAHPFFAGIDWQTLRQQTPPPIYPYLPGVSQDEDFRSSYTVPGDLEPGLDERQISRLLSAELGVGSSVAMPVKRSTAKNSFDLNDAEKLQRLEQQKTDKWHVFADGEVILKKGFVNKRKGLFARKRMLLLTTGPRLIYIDPVQMIKKGEIPWSPDLRAEYKNFKIFFVHTPNRTYYLDDPEGYAIHWSEAIENMRKLAYGDPSSTSAVSCSSGSSNSLAVISNSSAASSSNSPTVKRSSPVNAPQASTASDNRTLGSTRTGTSPSKKTASK
The following text describes a protein:
Function:
Baseplate protein that forms, together with gp48, the baseplate-tail tube junction. The tail tube first 2 annuli are formed by gp48 and gp54, which are in continuation of the spike complex. Involved in the tail assembly. Morphogenesis of the baseplate is completed by association of gp48 and gp54, which bind the upper part of the baseplate dome to form the platform for polymerization of the tail tube.
Subcellular Localization:
Virion. Note=Present in 6 copies in the baseplate.
Sequence:
MYSLEEFNNQAINADFQRNNMFSCVFATTPSTKSSSLISSISNFSYNNLGLNSDWLGLTQGDINQGITTLITAGTQKLIRKSGVSKYLIGAMSQRTVQSLLGSFTVGTYLIDFFNMAYNSSGLMIYSVKMPENRLSYETDWNYNSPNIRITGRELDPLVISFRMDSEACNYRAMQDWVNSVQDPVTGLRALPQDVEADIQVNLHSRNGLPHTAVMFTMHSISVSAPELSYDGDNQITTFDVTFAYRVMQAGAVDRQRALEWLESAAINGIQSVLGNSGGVTGLSNSLSRLSRLGGTAGSISNINTMTGIVNSQSKILGAI
The following text describes a protein:
Function:
Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site.
Subcellular Localization:
Nucleus. Note=Detected at replication foci throughout S phase.
Sequence:
MNPMNPMKPALPPAPHGDGSFAYESVPWQQSATQPAGSLSVVTTVWGVGNATQSQVLGNPMGPAGSPPGGSMMPGVAGGSSALTSPQCLGQQAFAEGGASKSYVQQGVYGRGSYPGGSSFTTGYAGGPAGLGLPTHAARPSTDFTQAAAAAAMAAAAATATATATATVAALQEKQSQELSQYGAMGTGQSFNSQFLQHGGPRGPSVPPGMNPSGMGGMMGPSGLSSMAMTPTRAAGMTPLYAGQRLPQHGYPGPPQGQPLPRQGIKRAYSEVYPGQQYLQGGQYAANTAQYAPGPGQPPGPASSYAGHRLPLQQGMAQSLSAPGPTGLHYKPTEQFNGQGASFNGGSISYSQPGLSGPSRSIPGYPSSPLPGNPTPPMTPSSNVPYMSPSQEVKSPFLPDLKPGLSSLHPSPSASVHCDELRLTFPVRDGVVLEPFRLQHNLAVSNHVFQLRDSVYKTLMLRPDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLSIERGDNKTSHKPLYLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGLLKKRLLPAEHCITKIKRNFSSGTIPGTPGPNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCRHIQCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMLGILIYIQNSDYEEITIDPTCSWKPVPVKPDLHIKEEPDGPVLKRCRTVSPAHVLMPSVMEMIAALGPGAAPFAPLQPPSAPTPSDYPSQGSNFMGPGTFPESFPSATPTTPNLAEFTQGPPPISYQSDIPSSLLTPDKSTPCLPGQMAPAGHLDPAHNPGPPGLHTPNLGPTPGTQLHHPNPSPASRQPLGQPNTGPISELAFNPASGMMGPPSMTGAGEASEPALDLLPELTNPDELLSYLGPPDLPTNSSDDLLSLFENN
The following text describes a protein:
Function:
Reversibly blocks voltage-gated potassium channels Kv1.2/KCNA2 and Kv1.3/KCNA3.
Miscellaneous:
MISCELLANEOUS: Negative results: does not inhibit voltage-gated potassium channels Shaker B, Shab, Kv1.1/KCNA1 and Kv1.4/KCNA4.
Subcellular Localization:
Secreted.
Sequence:
VDACYEACMHHHMNSDDCIEACKNPVPP
The following text describes a protein:
Function:
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Sequence:
MGSRRFVRGPLRAPGPYTVTVNVSAPDPSASVPARSGSGPRRAFLFADPAAHSLSPRMHRAAFAWAGLNGTYDAERVPAPELPTAMARLRAPDVLGANLSLPHKEAALPLLDGLSDAARAIGAVNTVIHRAGQLYGDNTDAPGLLQALAGSGLTGRLGAADRVVVLGAGGAARAAVYAGAVILGREVWVVNRTPARARALAAGWQGGGEVRAAGPGEVPWGQVGLVINSSSAGLDNPEETPLPGFDFGQLPAHAGVYDMVYKPRRTRLMRDAEAAGLPAENGLGMLAQQARLAFTAWTGVDVPVSVFLAALEAPATGRGAGDAARTEATR
The following text describes a protein:
Function:
Catalyzes the hydration of oleate at its cis-9-double bond to yield 10-hydroxyoctadecanoate, probably in the (R) configuration. Cannot catalyze the reverse reaction. Is not active with saturated fatty acids and trans-, cis-5-, cis-6-, cis-8-, cis-11-, cis-13-, cis-14-, and cis-15-double bond unsaturated fatty acids as substrate; is only active on cis-9- and/or cis-12-double bond of unsaturated fatty acids without any trans-configurations, producing 10-hydroxy and, to a lesser extent, 10,13-dihydroxy fatty acids. The hydration of unsaturated fatty acids is suggested to be a detoxification mechanism and a survival strategy for living in fatty acid-rich environments.
Sequence:
MYYSNGNYEAFARPKKPEGVDNKSAYLVGSGLASLAAASFLIRDGQMKGENIHILEELDLPGGSLDGILNPERGYIMRGGREMENHFECLWDLFRSVPSLEVEDASVLDEFYWLNKEDPNYSKCRVIENRGQRLESDGKMTLTKKANKEIIQLCLMKEEQLNDVKISDVFSKDFLDSNFWIYWKTMFAFEPWHSAMEMRRYLMRFIHHIGGLADFSALKFTKFNQFESLVMPLIEHLKAKNVTFEYGVTVKNIQVECSKESKVAKAIDIVRRGNEESIPLTENDLVFVTNGSITESTTYGDNDTPAPPTSKPGGAWQLWENLSTQCEEFGNPAKFYKDLPEKSWFVSATATTNNKEVIDYIQKICKRDPLSGRTVTGGIVTVDDSNWQLSFTLNRQQQFKNQPDDQVSVWIYALYSDERGERTNKTIVECSGKEICEEWLYHMGVPEEKISALAAECNTIPSYMPYITAYFMPRKEGDRPLVVPHGSKNIAFIGNFAETERDTVFTTEYSVRTAMEAVYKLLEVDRGVPEVFASVYDVRILLHALSVLNDGKKLDEIDMPFYERLVEKRLLKKASGTFIEELLEEANLI
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSGEFGNASPNPLSLNAPSTSAPVERAPIKTKITLRPPAQPPTPFYTMKPKLPQPSELLGSMDLLSVYDLSNSYNKFCSPQGMKRIAKEDLSSFLPHLYGEFNWQRGQEISWLKMLIEKPPITGKEIVPLNSSAMASFKLQPGIVDEPYRSLFDTGYEVKDGGQKDTKKEKRKLKMSIDPLEEDCIDNWAMDGNAPDMGSDEEGGTKKKKKKSDKDREERKERKKEKKEKKEKKKKEKEHN
The following text describes a protein:
Function:
Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.
Subcellular Localization:
Peroxisome membrane; Single-pass membrane protein.
Sequence:
MSPQADFDKAAEDVKKLKTRPTDDELKELYGLYKQSTVGDINTDCPGMLDLKAKAKWDAWNLKKGLSNEDAMQAYISKANELIEKYGM
The following text describes a protein:
Function:
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKRTGSASSVPRFQRSMSYDQSNSPTAGAHAKANTASPAAEPAPSSKEKENWNRQEENDLEEDDRDDFGTAAISKVAGKPGETDDEANEKLRTKYLLESFDEEQMQRYEVFRRANLNKTNVKKLANQILNQSVTPNVAIVISGFSKVFVGEIVELARKIQDQWGDTGPLSPDHLREAYRLSRQNRRLYPQSRHVSHLFR
The following text describes a protein:
Function:
Has a role in the initiation of spore membrane formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
MSNQSSSGSNTSDLDEESASSLVSSAASPFIDSDLETPRPNISRASTGQLAEDGDTSSQHEDSSEELKRQEVRGMRRHSDLSIDAKLGSSEGSTASSALPLTPRSPSNASWLLVRGGLLDSPILDINSVTQKSNLLNELKQVRSKLAALEHENGILSLQLSSSNKKDKNTSSVTTLTSEEDVSYFQKKLTNMESNFSAKQSEAYDLSRQLLTVTEKLDKKEKDYEKIKEDVSSIKASLAEEQASNKSLRGEQERLEKLLVSSNKTVSTLRQTENSLRAECKTLQEKLEKCAINEEDSKLLEELKHNVANYSDAIVHKDKLIEDLSTRISEFDNLKSERDTLSIKNEKLEKLLRNTIGSLKDSRTSNSQLEEEMVELKESNRTIHSQLTDAESKLSSFEQENKSLKGSIDEYQNNLSSKDKMVKQVSSQLEEARSSLAHATGKLAEINSERDFQNKKIKDFEKIEQDLRACLNSSSNELKEKSALIDKKDQELNNLREQIKEQKKVSESTQSSLQSLQRDILNEKKKHEVYESQLNELKGELQTEISNSEHLSSQLSTLAAEKEAAVATNNELSESKNSLQTLCNAFQEKLAKSVMQLKENEQNFSSLDTSFKKLNESHQELENNHQTITKQLKDTSSKLQQLQLERANFEQKESTLSDENNDLRTKLLKLEESNKSLIKKQEDVDSLEKNIQTLKEDLRKSEEALRFSKLEAKNLREVIDNLKGKHETLEAQRNDLHSSLSDAKNTNAILSSELTKSSEDVKRLTANVETLTQDSKAMKQSFTSLVNSYQSISNLYHELRDDHVNMQSQNNTLLESESKLKTDCENLTQQNMTLIDNVQKLMHKHVNQESKVSELKEVNGKLSLDLKNLRSSLNVAISDNDQILTQLAELSKNYDSLEQESAQLNSGLKSLEAEKQLLHTENEELHIRLDKLTGKLKIEESKSSDLGKKLTARQEEISNLKEENMSQSQAITSVKSKLDETLSKSSKLEADIEHLKNKVSEVEVERNALLASNERLMDDLKNNGENIASLQTEIEKKRAENDDLQSKLSVVSSEYENLLLISSQTNKSLEDKTNQLKYIEKNVQKLLDEKDQRNVELEELTSKYGKLGEENAQIKDELLALRKKSKKQHDLCANFVDDLKEKSDALEQLTNEKNELIVSLEQSNSNNEALVEERSDLANRLSDMKKSLSDSDNVISVIRSDLVRVNDELDTLKKDKDSLSTQYSEVCQDRDDLLDSLKGCEESFNKYAVSLRELCTKSEIDVPVSEILDDNFVFNAGNFSELSRLTVLSLENYLDAFNQVNFKKMELDNRLTTTDAEFTKVVADLEKLQHEHDDWLIQRGDLEKALKDSEKNFLRKEAEMTENIHSLEEGKEETKKEIAELSSRLEDNQLATNKLKNQLDHLNQEIRLKEDVLKEKESLIISLEESLSNQRQKESSLLDAKNELEHMLDDTSRKNSSLMEKIESINSSLDDKSFELASAVEKLGALQKLHSESLSLMENIKSQLQEAKEKIQVDESTIQELDHEITASKNNYEGKLNDKDSIIRDLSENIEQLNNLLAEEKSAVKRLSTEKESEILQFNSRLADLEYHKSQVESELGRSKLKLASTTEELQLAENERLSLTTRMLDLQNQVKDLSNIKDSLSEDLRTLRSLEDSVASLQKECKIKSNTVESLQDVLTSVQARNAELEDEVSRSVDKIRRRDDRCEHLSGKLKKLHSQLEEQHETFFRAEQQRMTQLGFLKETVKKQEKLLKKLNLRQEQLIPRSSILVYESYIRDIEKEIIVLQERLNGIELSQQLPKGYFGYFFKTNRVEMEVLDSFKQQVAKLQFLAGAEFIVKFKEDLEKCAAEEKEKQATFDNYSEKVENLGKSIEALYFALNREISFRKSLALSKSAYHNLLVRDSPKFNPDSQITYSIPVTNTKQSLLRSAILCVISLQRLRLLGQRHSFCEEVIENLSCV
The following text describes a protein:
Function:
Essential transcriptional activator that binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of gene expression. Bind both the promoters of ribosomal protein genes and the rDNA locus and activates transcription at these loci. Recruits FHL1 and IFH1 to promoters.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MSDQLEKDIEESIANLDYQQNQEHHETEQDKDKEHQDVEKQSSEEETKGIEHVTDSNTDVIGVTKSQDTEEVIENSPVDPQLKEQQESTTKMSLSERDLVDEIDELFTNSTKTVTENNQPSETNKRAYESVETPQELTPNDKRQKLDANTETSVPTELESVNNHNEQSQPIEPTQERQPSTTETTYSISVPVSTANEVERASSSINEQEDLEMIAKQYQQATNLEIERAMEGHGDGGQHFSTQENGQPSGSSLISSIVPSDSELLNTNQAYAAYTSLSSQLEQHTSASAMLSSATLSALPLSIIAPVYLPPRIQLLINTLPTLDNLATQLLRTVATSPYQKIIDLASNPDTSAGATYRDLTSLFEFTKRLYSEDDPFLTVEHIAPGMWKEGEETPSIFKPKQQSIESTLRKVNLATFLAATLGTMEIGFFYLNESFLDVFCPSNNLDPSNALSNLGGYQNGLQSTDSPVGARVGKLLKPQATLYLDLKTQAYISAIEAGERSKEEILEDILPDDLHVYLMSRRNAKLLSPTETDFVWRCKQRKELLLNYTEETPLSEQYDWFTFLRDLFDYVSKNIAYLIWGKMGKTMKNRREDTPHTQELLDNTTGSTQMPNQLSSSSGQASSTPSVVDPNKMLVSEMREANIAVPKPSQRRAWSREEEKALRHALELKGPHWATILELFGQGGKISEALKNRTQVQLKDKARNWKKFFLRSGLEIPSYLRGVTGGVDDGKRKKDNVTKKTAAAPVPNMSEQLQQQQQRQQEKQEKQQQEEQQAQQSEQQQEPQQEQQQEQQQEQQQEQQQEQQQEQQQEQQQEQQQEQQQEQREETQQTEQEQPDQPQEEQQQEKEQPDQQQQEKEQPDQQQPDQQHPDRQQQEQIQQPESSDK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that functions as a regulator of MED25 stability by targeting MED25 for degradation in a RING-H2-dependent way. Proteasome-dependent degradation of MED25 seems to activate its function as positive regulator of FLOWERING LOCUS T (FT) and is important to induce the expression of FT and consequently to promote flowering.
Domain:
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
Sequence:
MNPMQGPRSIGGSSTEVNQVDGESIYCTETSLNTMLNPADTGFPNNSTPSGRPTYASSSSHAAQDHTWWRFGESSSIPGPSDQVNSIGIKTSHQLPQDGTHHFVGYGSEGRQTGLNGMMVDGGVHAGSHIRNVPSFLRGSSSNPMPQHVDMSMDMDSDNCNAQTSGVVIRHNSYGSSLGSSVQAAGESSSGPASPFGGWGSSCKRKALEGSPSHYFSGETPNRIVQTENSASHASLSQYGASSSLSLATPSQSSPNVTNHFGRTEQMFGSGGGRAVAASAFHSTRNTDTLSRAGRRLNPRQPQESVAFSVSHGGTSVRPTGSLQQNLPLNSPFVDPPDVRSSSITSGSNTGENQTNIVHLPALTRNIHQYAWDASFSSRASNPSGIGMPAERLGPQWETPRSNQEQPLFAPATDMRQPVHDLWNFARGSPGSSVDSLFVPRAGPSSAIHTPQPNPTWIPPQNAPPHNPSRTSELSPWSLFPSIESPSASHGGPLPLLPAGPSVSSNEVTMPSSSNSRSHRSRHRRSGLLLERQNELLHLRHIGRSLAADGNGRNQIISEIRQVLHAMRRGENLRVEDYMVFDPLIYQGMTDMHDRHREMRLDVDNMSYEELLALGERIGDVSTGLSEEVILKAMKQHKHTSSSPSSVELHQNIEPCCICQEEYVEGDNLGTLKCGHEFHKDCIKQWVMIKNLCPICKTEALKTP
The following text describes a protein:
Function:
Binds to and hydrolyzes insoluble and soluble xylan substrates (By similarity). Exhibits xylanase activity.
Subcellular Localization:
Secreted, cell wall.
Domain:
The GH10 domain binds to xylan.
Sequence:
MKRFTVCCFSNKIHKNGDRNPDKKSRESMEVSRKDNEEPEKQNNNNVASIIGSDRTNVIVNHDFSSGMHSWHPNCCEAFVVTAESNVSHGVLDPSKCGSYVVVKNRKETWQGLEQDITNRVKPCSLYKVSATVAVSGPVHGLVEVMATLKLESQQSQTNYQFIAKTCVFKEKWVRLEGMFSLPSLPEKVVFYLEGPSPGIDLLIQSVTIHRESEPELERVTAEDETIVVNPNFEDGLNNWSGRSCKIVLHDSMADGKIVPESGKVFASATERTQNWNGIQQEITGKVQRKRVYEATAVVRIYGNNVTTATVQATLWVQNPNQRDQYIGISTVQATDKEWIHLKGKFLLNGSASRVVIYIEGPPPGTDILLNSLTVKHAEKIPPSPPPSIENPAFGVNILTNSHLSDDTTNGWFSLGNCTLSVAEGSPRILPPMARDSLGAHERLSGRYILVTNRTQTWMGPAQMITDKLKLFLTYQISVWVKVGSGINSPQNVNVALGIDSQWVNGGQVEINDDRWHEIGGSFRIEKNPSKALVYVQGPSSGIDLMVAGLQIFPVDRLARIKHLKRQCDKIRKRDVILKFAGVDSSKFSGASVRVRQIRNSFPVGTCISRSNIDNEDFVDFFLKNFNWAVFANELKWYWTEPEQGKLNYQDADDMLNLCSSNNIETRGHCIFWEVQATVQQWIQNMNQTDLNNAVQNRLTDLLNRYKGKFKHYDVNNEMLHGSFYQDKLGKDIRVNMFKTAHQLDPSATLFVNDYHIEDGCDPKSCPEKYTEQILDLQEKGAPVGGIGIQGHIDSPVGPIVCSALDKLGILGLPIWFTELDVSSVNEHIRADDLEVMMWEAFGHPAVEGIMLWGFWELFMSRDNSHLVNAEGDVNEAGKRFLAVKKDWLSHANGHIDQNGAFPFRGYSGNYAVEVITTSSSKVLKTFGVDKEDSSQVITVDLQGL
The following text describes a protein:
Function:
Component of the GPI transamidase complex. Involved in transfer of GPI to proteins.
Miscellaneous:
MISCELLANEOUS: Present with 7520 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSNANLRKWVGFCFVAIYLFLGVPLWYKLTTVYRASLPINYIESLQNNKFQDIHLVIPVYVKSDTYRFPDVHDAIQVQVNHLLNSQEQRVPWSLQVLPYNETIEQMESEGNQFHVVTLKLDEFIGYSSAYDTKETLVYYDDAAVLSNDLPFFVAQTLVEHTFQLEWTHLNKTCEGVSTNNDVAISYDPNIHLSVTLLSGDGNPVAWEIEPTLTDYFSPFRKFLSPLVNFTVDSSIVYHNDLNLHSLNGSCTSVTWFDLSHTIDLSELSSMAYYPEDSALNLAIVFPSASSSPDGLAFINGTRISDEITTLDWNSYLVPQWGVIIINKMPLKPNSVISEDYLEPMMYRFATDIFQLLGLTEGSQDLLSPYITIDSFKRLTILQNLDKATETLWSLVKLTQQFQGMSIPREVSDNVIEALDLRLQIIDLLNDPGKGGDIVWNNALHLSNELVKLCEKAFFNGEMVQQNFFPQEHMIAVYLPLLGPISAVMFFGFYNVMKEKNQKSKKNGTEREVAKEKLELKEAQKLHAIDGEDEL
The following text describes a protein:
Function:
Structural component of the virion that forms triskelion structures consisting of three molecules that stabilize three hexon trimers at the center of each icosahedral facet and fixes the peripentonal hexons (By similarity). Dispensable for assembly. During virus entry, recruits the anterograde motor kinesin-1 to the capsid docked at the nuclear pore complex thereby subjecting the docked capsid to a pulling force. The resulting tension leads to capsid disruption, dispersion of capsid fragments toward cell periphery and eventually viral DNA entry into the host nucleus.
Miscellaneous:
MISCELLANEOUS: This protein is only encoded by mastadenoviruses, and may therefore play a role in mammals tropism.
Subcellular Localization:
Virion. Host nucleus. Note=Located in the canyons between the hexons on the outer surface of the capsid. Forms a sort of hairnet on the outer side of the virion. Present in 240 copies per virion.
Domain:
Three N-terminal domains of hexon-interlacing protein form triskelions between hexon capsomers.
Sequence:
MSANSFDGSIVSSYLTTRMPPWAGVRQNVMGSSIDGRPVLPANSTTLTYETVSGTPLETAASAAASAAAATARGIVTDFAFLSPLASSAASRSSARDDKLTALLAQLDSLTRELNVVSQQLLDLRQQVSALKASSPPNAV
The following text describes a protein:
Function:
Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans.
Miscellaneous:
MISCELLANEOUS: Present with 2310 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MLKSLKSRRLILKRLVTLLLSLFFSYLIFSASRNVTSSNKLNNHASERTAVESSAFNWIEKRQHQVRSENLMNRLSAYFLPFLSRSSHKERVLLRQLGNNEIAKSDKCRYIFEVLYKIDPDWDNAQTAKFYNVDGVDNTLASLLGERLRSYDYCFLSGQLDPTAIFANSTVNPHDLQNRMFPFLKKINEESKTVMWPIITDMTTGEAVPAPEVDMESSNFNGNFWSNWNRLSKGRGFVLTIAEKDVPLFLKQLKVMEFSKNELPFQIVSTGNELSAESIAKISETAKETEQRVYLVDCSTVLDTNFANTYISFFQNKWVATLFNTFEEYILLDADVVPFVGSDYFFDSPSYRESGILLFKDRVMENEQTFQYCIEMLNEVEPSAQERRFIGSRLVFDSSLPFSSETSEEASVYYNFFKKLRLHHVDSGLVVVNKLEKLNGLLMSFMLNLDGKLQRCVYGDKEIFWLGQLYAGQDYSINPVDGSIIGPVNEEPENDDGHKSGMYYICSTQIAHSDSKNRLLWVNGGLKTCKISNSAEDDFGREPEYFKSRYGDISKLKRIYDASLNVEGLIVPDVSVHPWMQIKECSNYMYCAYATGDGHTNSELDEGRLITFTEKELRYINDISRTWNAN
The following text describes a protein:
Function:
Functions as a key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis. Induces proteolytic processing of caspa and caspa-dependent apoptosis. Involved in innate immune response by acting as an integral adapter in the assembly of various inflammasomes which recruit and activate caspase-1 leading to processing and secretion of pro-inflammatory cytokines. Caspase-1-dependent inflammation leads to macrophage pyroptosis, a form of cell death (By similarity). The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Clustered PYCARD nucleates the formation of caspase-1 filaments through the interaction of their respective CARD domains, acting as a platform for of caspase-1 polymerization (By similarity). Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome (By similarity).
Subcellular Localization:
Cytoplasm. Inflammasome. Note=Co-localizes with nlrp1, caspa and caspb in the cytoplasm. Co-localizes with caspa and caspb independently at large cytoplasmic aggregates, known as specks.
Domain:
The pyrin domain mediates homotypic interactions with pyrin domain of other proteins.
Sequence:
MAESFKEHLQEAFEDLGADNLRKFKSKLGDRRQEPRVTKSAIEKLKDEIDLADLMVGVFTSKDAVSVTVEILRAIKCNAVADDLLRNTGQSESKGALSDESKCASSKAVSKVAFSKVNFIDEHWKELIDRVNNVDPILDILRQKKVITNEDYCTIRNKETPQKKMRELLTGPITCAGNKGKEVLYDALRESNKFLMDDLEDAE
The following text describes a protein:
Function:
Most effectively accelerates the intrinsic GTPase activity of ypt7.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTTLESLDMPEMTEVEDDTVDIHIDNSKVALLFSKSKVFVHPTSKMKDNISGYLSLSKSKALGNSSVAGSDILLSWVPDSFLKNRPRDLSVFQNAETLSNGSIREWVEIPQHLDYSFSVRLCSIYSIIFRPPRYGWNYGSIVINLRDSGESLPPLFFHDDECISTIEYGKQITRDRFDPFDESGNMFWGGTHLLMQLKKYASLEQSSHESQLYLVNPSPEDTVAFQSVELQKVISNNRLNSSSTPPTPRSSSSIFNPFRRALHDLSFTVLERFSRVTNYGKSEVDRLMEHKVTKSILPHLPRELQVLLESKRVQKLTEEYDPARMFLARWAEGIVEQSESNNSQPVNNAGVWTDAQREEDSSLGPFELVYIEERVKRDDPLSVEQWNSMFNAHGKLQVDVHRVLGIIFHGGIQPSLRKEVWPFLLSVYPWDSTSEERRVIYLSLQEEYCTLKRKWYEDIHKQFNDRWFIEQRNRIEKDVHRTDRQHEYFQIEDLPHPDPQSTFTGTNMNMEMMKDILLTYNEYDTELGYVQGMSDLLAPIYVTFNDNALTFWGMVGLMKRLHFNFLRDQSGMHRQLDTLRLLIEFMDPELFAHLEKTDSSNLFCFFRMLLIYFKREFDWEVLLKLWDVLFTNYLSYDYHIFVAYAIAERHREVLLNQTSAFDEVLKYFNELSGKLALEPTLICAEQCFYQFKNKLALIDRKQMEETNSDEDGSKETDLPTIAPYLRNLLKTSQPQYTPSGKQE