lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Regulatory protein of the TOL plasmid xyl operons. XylS activates the xylXYZLTEGFJQKIH operon required for the degradation of toluene, m-xylene and p-xylene.
Subcellular Localization:
Cytoplasm.
Sequence:
MHQPSDFQVFRTLDRTSNARLLRSSTLSDGLALAHWYRDEAEILGYSDPGHHTLSLYLQGGWQTFRRDRPGLYGGPDRFCVMPAEHHSDWAVTRGLGFMHLYISPERLAGAAVRTLDCEPRSLQLEERTYIQDEPLAALCRTLERQDWNEPGEHLLCTSLAHQAVDHLLLTGCGRRTDVRWQGGLAAHVRRRLADYIESHLEQPLELGSLAELAALSEYHFARMFRVSFGLPPHRYVLERRLARARDLLAYSAQPLQEVSLACGFASPSHFNRRFREAHGATPGQYRAALKAS
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MKKRRKSGPGNSSDFLEKWIRAEALAPGSNPMAIKLPRQVLVNPATGFKPYAGASRFDQLPLSGKTLKGLKEAKYESMTEIQRAALPHALAGRDVLGAAKTGSGKTLAFLIPLVEKLYRLRWRSGHGLAGIVISPTRELAEQIFLELGKVAKHHRFLTRGLLIGGSHDVGLESNRVGELCILVATPGRLLHHLHQTATLDCTYLQVLVLDEADRILDSGFARELTDILAALPNQRQTLLFSATQTRSVSDLARLSLRDPEYLAVHSESAVATPATLQQKVVIVKLHRKIETLWRFIKTRLSSKLLVFLSTCTQVKFVYGAFKHLRPGVPLSCLHGRQKQGKRDLVFSNFNQARPSVLFATDIAARGLDFPAVDWVVQVDCPEDVETYIHRVGRTARNKLKGKSLLLLDPSEVKMIELLRQHKIPIEEAAEAAPRGESCDLSQQIGAWLSKDPGLKHSAQRAFVTYVRSVVLQRNKEVFNVGKLPLPEFAFSLGLAIAPRIRFLGKQAASVKNESQSLKNELAKSSSSSSKVAGEVKSCAADEDGDLFMRLKKRGRDFLFGVLEDGSLFSSCRHKKTKRLKIDARSGTGQRLVFDEDGSSQDERGGKELWSSNARIAERYKRLQQEMKERDRQDKVLERLRLRDKRLKRKARERKLDLIDEDMSEQGDDKPELLDSLSLADQEALALKLLSRSNH
The following text describes a protein:
Function:
Required for secretion of EsxA (ESAT-6) and EsxB (CFP-10) and for virulence. Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm.
Miscellaneous:
MISCELLANEOUS: Maintenance of wild-type levels of EspA requires both EspC and EspD; MISCELLANEOUS: Has been postulated to mediate virulence through maintenance of mycobacterial cell surface integrity , but studies of detergent sensitivity of various strains and mutants indicate that EspACD and ESX-1 deficiency does not impact the cell surface integrity.
Subcellular Localization:
Secreted. Note=Secreted via the ESX-1 / type VII secretion system (T7SS). Secretion of EspA, EsxA and EsxB is mutually dependent.
Sequence:
MSRAFIIDPTISAIDGLYDLLGIGIPNQGGILYSSLEYFEKALEELAAAFPGDGWLGSAADKYAGKNRNHVNFFQELADLDRQLISLIHDQANAVQTTRDILEGAKKGLEFVRPVAVDLTYIPVVGHALSAAFQAPFCAGAMAVVGGALAYLVVKTLINATQLLKLLAKLAELVAAAIADIISDVADIIKGTLGEVWEFITNALNGLKELWDKLTGWVTGLFSRGWSNLESFFAGVPGLTGATSGLSQVTGLFGAAGLSASSGLAHADSLASSASLPALAGIGGGSGFGGLPSLAQVHAASTRQALRPRADGPVGAAAEQVGGQSQLVSAQGSQGMGGPVGMGGMHPSSGASKGTTTKKYSEGAAAGTEDAERAPVEADAGGGQKVLVRNVV
The following text describes a protein:
Function:
Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases.
Subcellular Localization:
Cytoplasm.
Sequence:
MEDPETVDREFNDEEEDQDEDWGDWGADDNEEEESDPDFLCLFCDSKYSSCDALFEHCSSIHHFDFLSIRETLSLDFYGSFKLINFVRSRVAENRCWSCGLVCQSNQDLQTHLHETANFEEIKLHLDDDKYLNPFMQEDPLLYSFSQDEEGEDDDATALEKEEIMRDLREFGEICIDDGDIIDALASDFDTLNEDRREGASASNGYYGMENISEKEIGSCIGAKEHVGSFKRKPKDKHLRVSFANVVSKEIKNVNENYFGAYSSFGIHREMISDKVRMDAYRQAILNNPSLMKGATVLDVGCGTGILSLFAAQAGASRVIAVEASEKMASVATQVAKDNGLLCSASPNAGNNHYTGVIKVVQGMVEELDKSIESHSIDVLLSEWMGYCLLYESMLSSVLFARDHWLKPGGAILPDTATIFVAGFGRGGTSIPFWENVYGFNMSCVGKELVEDAAQTPIVDIVDSHDIVTDAAVLQTFDLVTMKPEEMDFTASIRLQPKLDHPADTNASMDLEQKPTWCHGVVLWFETGFTSRFCRETSTILSTSPFTPKTHWSQTILTFREPIAMAAGKPNAKKSGGVGSDACPASSVHLRISIIRAAQHRSIDISLETTGIACDGRKHSWPVQIFNLS
The following text describes a protein:
Function:
Presents an endo-cleaving activity on polygalacturonate or partially methylated pectin. Is effective in the maceration of plant tissue, and has an important role in soft-rot disease. Is 280-fold less active against polygalacturonate than the major pectate lyase PelB. When assayed on polygalacturonate, PelL releases oligogalacturonates of different sizes; upon prolonged incubation, PelL degrades the primary products to unsaturated tetramer and pentamer in addition to unsaturated dimer and trimer. When assayed on oligogalacturonates (degrees of polymerization of 2 to 8), it preferentially forms unsaturated tetramer, and displays the highest activity on the octamer.
Subcellular Localization:
Secreted.
Sequence:
MKYLNCFISTGLAAFFLVNSTSVLAADCSSDLTSGISTKRIYYVAPNGNSSNNGSSFNAPMSFSAAMAAVNPGELILLKPGTYTIPYTQGKGNTITFNKSGKDGAPIYVAAANCGRAVFDFSFPDSQWVQASYGFYVTGDYWYFKGVEVTRAGYQGAYVIGSHNTFENTAFHHNRNTGLEINNGGSYNTVINSDAYRNYDPKKNGSMADGFGPKQKQGPGNRFVGCRAWENSDDGFDLFDSPQKVVIENSWAFRNGINYWNDSAFAGNGNGFKLGGNQAVGNHRITRSVAFGNVSKGFDQNNNAGGVTVINNTSYKNGINYGFGSNVQSGQKHYFRNNVSLSASVTVSNADAKSNSWDTGPAASASDFVSLDTSLATVSRDNDGTLPETSLFRLSANSKLINAGTKESNISYSGSAPDLGAFERN
The following text describes a protein:
Function:
Transcriptional regulator that might play a role under hypoxic conditions (Probable). Regulates the expression of ald, which encodes L-alanine dehydrogenase. Serves as both an activator for ald expression in the presence of L-alanine and a repressor in the absence of L-alanine. Acts by binding directly to the upstream region of the ald gene. Four AldR-binding sites (O2, O1, O4 and O3) were identified upstream of the ald gene. O2, O1 and O4 are required for the induction of ald expression by alanine, while O3 is directly involved in the repression of ald expression, by occluding the access of RNA polymerase to the ald promoter. In addition to O3, both O1 and O4 are also necessary for full repression of ald expression in the absence of alanine.
Domain:
Contains an N-terminal DNA-binding domain, followed by a rather long linker and a C-terminal effector-binding domain, which is also involved in oligomeric interactions.
Sequence:
MIILFRGHMRDNSTEHKTRRAASSKDVRPAELDEVDRRILSLLHGDARMPNNALADTVGIAPSTCHGRVRRLVDLGVIRGFYTDIDPVAVGLPLQAMISVNLQSSARGKIRSFIQQIRRKRQVMDVYFLAGADDFILHVAARDTEDLRSFVVENLNADADVAGTQTSLIFEHLRGAAPI
The following text describes a protein:
Function:
Component of the transcription regulatory complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. The SAGA complex predominantly acetylates histone H3. Involved in SAGA complex coactivator function but not essential for SAGA complex assembly, histone-modifying activity or chromosomal recruitment. Required for oogenesis; involved in transcriptional activation.
Subcellular Localization:
Nucleus. Chromosome. Note=As part of the SAGA complex associates with chromosomes near the transcriptional start site, matching the distribution of RNA polymerase II.
Sequence:
MKTSGASNTDELNKSSHSKVSKKSTKSRSKSAKLELTGKNSLSASASSSIASAVSGGVAVGSLPATPTHLNMVTTPTTPTSSLGNYNLFDASFAVAGSGGHGLAGGIAGAEASGNSSRMGHQKSYAGFDPRSIKIFWEQHDQTDVELSQDVCARLAEDASYKVWELINNVKIYSRHSGGVVTYDLVNEVLKDADVPPMLGAMDSDWDRIDYDGSFYFHSDKIFELSAEFQKEVNLCTPDDADFQSICPVEDKHMDQLRQCVQSLVTAALFADSKSQTAAVCHAFQTPLMGSIYRVIVSKMVQLLAFKQQDHLSQRCWRLLRACNYNATANHNACRPEYFNLAEVLVSQLMAPYETIKAPHVDPDPGQTTSIKMEFEEELKVEPDQCHNPETQENPEVMGVEKQEQEPQMFPGESTMEHTIYKLQSEEEELNPQPEAEHLSSYFACPVGNGLVDELCETIGQLASQSGYLHAECLFLIKRRLARFFEGRHVSSERDFRYISRAVRGLIALGEYAFREFIPYIYKLRVEEIPDSLWPDLAPAAIFLGGHDDVYLYEWLEYGCGAALQPFLVHYARAYEKMVTRRYVKAKQPAYRIESVPGVRRLEWSTLAAAMCHGDDPSKALKPKPTLCEAFPDLQSPNLQLNCAGNIRFKFAGCRPVLLKPKVATVPHSEDSPSSAANGGGGGGASSDILIAKRKLFKPLTNVRKWSPISGYHYLRI
The following text describes a protein:
Function:
Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3. Essential for Set1 association with chromatin and trimethylation of histone H3 at 'Lys-4' at transcription puffs. Additionally, is critical for general chromosomal association of Set1.
Subcellular Localization:
Nucleus.
Sequence:
MTDKRKYKKTVSFTRCTAIIFLTTKEVSKQKEEIRREIAREFDLPERKSKIATILKQEDQAYCICRSSDCSRFMIGCDGCEEWYHGDCIGITEKEAKHIKQYYCRRCKKENPELQTIFRLVATERAAASNAASTSLNAPGVGPSGAAPAAAPVASATTSQQAPPPTTAAAKRKNSSAREPKMGKRCGTCEGCRRPNCNQCDACRVRVGHKPRCIFRTCVVQAATVLKESQATQAGPSRKREKAAPKSRNVQVGPRAASPEIFLNPELQGIRQCYGPNCCSHARPQSKYCSDKCGFNLATKRIFQVLPQRLQEWNLTPSRAAEETRKHLDNIRHKQSLVRFALAELEKRSEELNMVVERAKRSSIDTLGSQDTADMEDEQSMYCITCGHEIHSRTAIKHMEKCFNKYESQASFGSIFKTRMEGNNMFCDFYNPASKTYCKRLRVLCPEHSKDPKVNDTDVCGSPLVNNVFNPTGEFCRAPKKNCFKHYAWEKIRRAEIDLERVRQWLKMDDLMEQERVMRQQLTSRANLLGLMLHSTYNHEVMDELVRKQQEHLVEFEKQRRRLAHQQQIQTQQKQYQEKQKLMLQQQQQQQQQQQQQQQQQQQQQLQQPQQQQQQQQQQQQEQQQLQLKPHHLQQLQLQLLQQQQKKAQIPQKTQIIYLQKKT
The following text describes a protein:
Function:
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
Sequence:
MTLLTRIKTETILLESDIKELIDILISPSIGTDIKYELLSSYSEREIQQQELTYIVRSLINTMYPHQPCYEGAMCVCGTGGDKSNSFNISTTVAFVVASAGVKVIKHGNKSITSNSGSTDLLNQMNIQTTTVDDTPNQLNEKDLVFIGATESYPIMKYMQPVRKMIGKPTILNLVGPLINPYHLTYQMVGVFDPTKLKLVAKTIKDLGRKRAIVLHGANGMDEATLSGDNLIYELTEDGEIKNYTLNATDYGLKHAPNSDFKGGSPEENLAISLNILNGKDQSSRRDVVLLNAGLSLYVAEKVDTIAEGIELATTLIDNGEALEKYHQMRGE
The following text describes a protein:
Function:
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
Subcellular Localization:
Cytoplasm.
Sequence:
MAIRIKSTRVGRFVSESVGLGHPDKICDQIADSILDQCLLQSKTSHVACEVFASKNLILIGGEISTSGYVDVVQTAWRILRNLGYNETDFSFLSCINNQSLEINQAVLKNNEINAGDQGITVGYAVNETKQLMPLGVLLAHSFLKQAEKLTKQFDFLKNDMKSQVVLNYSLNQVECEEVLLSIQHTNAISLTELRKVIENNVILPVLNQYGFQDKKPTCLVNPGGSFVLGGPMADTGLTGRKIIVDTYGPYAHHGGGSFSGKDPSKVDRTGAYFARFIAKHIVSLGWASECEVSISWVFSKPNPQSITVKCFNTNIQYDEVLINRVVNNYFNWSITKIIDKLKLLDFVKYSDYAVYGHFGNDLSPWEQPTELDKLECLIKNFH
The following text describes a protein:
Function:
Involved in autophagy in a nutritional condition dependent manner. The ATG1-ATG13 protein kinase complex regulates downstream events required for autophagosome enclosure and/or vacuolar delivery. Becomes a target of autophagy under nutrient starvation. Connects autophagy to plant nutritional status.
Subcellular Localization:
Cytoplasmic vesicle, autophagosome.
Sequence:
MDFPENLPSDIGRLEQIVSHFFPKALHIVLNSRIPSLQSRGRTRERLSGLNVRKSDKWFNLVMGDRPAALEKLHSWHRNILDSMIIDIILVHPISNDNLDDDDDHSDSVVRSAETVIERWVVQYENPLIMSPQSSDSATRYQKVYKKSIILLRSLYAQTRLLPAYRVSRQLSSSLASSGYDLIYKVSSFSDIFSGPVTETMKEFRFAPVEVPPGRLCASVTYRSDLSDFNLGAHITLPPRIITDYVGSPATDPMRFFPSPGRSVEGHSFTGRAGRPPLTGSSAERPHSWTSGFHRPPAQFATPNQSFSPAQSHQLSPGLHDFHWSRTDAFGDNHQLSPPFSPSGSPSTPRYISGGNSPRINVRPGTAPVTIPSSATLNRYVSSNFSEPGRNPLPPFSPKSTRRSPSSQDSLPGIALYRSSRSGESPSGLMNQYPTQKLSKDSKYDSGRFSGVLSSSDSPRFAFSRSPSRLSSQDDLDDPDCSCPFDFDDVDESGLQYSHSLDRRKTSSSISQSLPLGRRSSQDAAVGVLVHMLKTAPPLRQDSSTYMASMSGVQREGSVSGTESEFSMARSTSDALEELRNYKQLKDLLLSKSKSGSGPTRVH
The following text describes a protein:
Function:
Acyltransferase which mediates the conversion of lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA or eicosapentaenoic acid (EPA) as the acyl donor. Prefers sn-2-LPI rather than sn-1-LPI as the acyl acceptor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEKIIGLMSRDDWVYTGLLLFSFAASCYVRKLGNNILASGALGFAMALFIIGPRIAYSLGICAIAVGIQAFAPKKKVPFYVFLTTFTYLMFVRFAHYFLPVVEVASHTNVIQLIITLRIIGITFEENDAWLHKNDENATKRYLTRMPTLLEKFAYFYHFCGLFTGPYYTYQMLLDSQNPALQSWDPTPEVTSRFVRLLWSVPAFVITNHYFPLDSLRSDAIWEVSFFTRLVYAALIFVVFKTRVYSAWAIAESICVILGIGIYPAASNPKIIVGPTDLKVFEGLRDKENVEMNSDAIVNLDIPKVEFSDGFRDGMKAWNRSVQTWLALYVHSRVKFMRVETTMLVSAIWHGTYAGYFMSFGVVAMCAILEDVIFKLVPVNPETGLRPQWFRILYTHTIRCRGFEMLATGFLLKNASDVHHFWSSIYYWLPLLCVPFYIYSVKTAAPKLKLVV
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Sequence:
MDDFFEDNQTHEISNGQSGGFQEQQYTAFDAFENGTPPQGITFNTYVSPEQQLRKDKLRLIEDERLAQIREKDQQESLLKQQQKQKAQEYLQVFKKQQEADIAQKRSQNKQKQEIWLENLKNHYQNKNSWEQIASNIALRDGEYPGQKDVTQMRQAILNKRSDLTK
The following text describes a protein:
Function:
Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, perinuclear region.
Sequence:
MGPPLKLFKNQKYQELKQECIKDGRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDDPHLIVGNISNHQLIQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPRKLDKYAGIFRFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTTTDIIVDFTGTLAETIDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVETDWGLLKGHTYTLTDIRKIRLGERLLEVFSTEKLYMVRLRNPLGRQEWSGPWSEISEEWQQLTVADRKNLGLVMSDDGEFWMSLEDFCRNFHELNVCRNVNNPIFGRKELESVVGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVEMNRRFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQHGRTSEFLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQITVHSAEGLEKKYANETVNPYLVIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIVQVWNSRKFCDQFLGQVTLDADPSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDLTEL
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subcellular Localization:
Midbody, Midbody ring.
Sequence:
MSSSDDTSSDYDDYDDYELDEDDTEKEPSKWNNVRDGWQEFLEDETAFFVSQEDQSKQSGDIQIDDSNKFYDPLGILKLPPRKAASVKKELLSLESESFSPVTFLSEIHSQTNFTELSIGVKKLKEESTSKAKEIKYLVKENFEHFVKCKDTVDEVYNLISNSKMLEDMSGSFIKIINKSSTVYDPLLSNKKKADEIRKVLTLLNKYKVIFKLPGKIQENIKQNEYEKAVHNYKNAKTLITSSQKKEFQKILLDIEKIAEDFRIQLFHALADPSTKLEQLKKSIKTLMEIGNGKGDFSQIGDPCWYFLSTRYNAITLLIKQCSEDNTLPNYKIIRKLSILLLSNVPNLFKMGVYYIEGKFEDNKEYLRYKQQQQIQLQQQQQLIQQQQQLQQQQQQQQSGKTKDSKSVNVVVYYLDETFSSYRMDQEKKVKDLIELCRKRFIEEEDDEFCLYKLSEKKIKSEDKSTTTTNIKLLELSHDESPFKLQKKWADKNSSTKNHRFLFKRKNEEFTVNNSKAGNGTSIYDKEANITQIDLNASYKTHKKQNSAATSAMNEEKFKQLIINIMELYSSKVEQLFFDQNQEDFPEDSDDEEENLFDQIISTTSVNEDGNHHHGGGGGGGGGGGDTINSSDLSIHMVENVNEVIKCQEMLQGIGMPELYLSSINSLTESLILHFIRQICSEMVAEVSFLYLLEDWTINESSEDALASGNQVDGMITTRLMGEFVNTIKVNLAKLSFLSNKPMLLPSVESALCEAIESFGDCLHHLAFNNESIQSTIEDSLNQMSNDEKAENELNGIIPKIDISSPQQQQQQTQNQSQQGQVQQGENQQQQTSSYMTTEFNSSEKLLLTLSNCSTVVSKTAVQLRGFYVGLFHQPMGSYLKKVIEKLGVLERLILERYVNEKNLMIGEFITRGVLFSGSTWLVNSQPTKVSSFILTILTKMVFIHHEIMKTINSIDISFGVIQRIFEFLLISLRHNFSLVDPLFISNEGKSQFLLDILFIENVLESYGNEKTVKLSSFIRKDLLFLNPIQQQQQQQPTQSISHQHQQQSSTSRFYSTLNYGGGSGFNINATTANLDPILKRNIEKTSLLFSCFKI
The following text describes a protein:
Function:
Key assembly factor specifically required for the stability of axonemal dynein heavy chains in cytoplasm.
Subcellular Localization:
Dynein axonemal particle.
Sequence:
MSTFEKPQIIVHIQKGLNYTVFDCKWVPCSAKFVTMGNFARGTGVIQVYEIQRGDLKLLREIEKAKPIKCGTFGAASLQQRFLATGDFDGNLHIWNLEAPEIPVYSVKGHKEIINTIDGIGGLGIGEGAPEIVTGSRDGTVKVWDPRQKEDPVANMEPAQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNMSLRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVTEKAHKSTVWQVRHLPQNRELFLTTGGAGNLHLWKYEYPAHRSKKDSEGLEMGVAGSVSLLQNVTVSTQPISSLDWSPDKRGLCICSSFDQMVRVLIVTKLQTI
The following text describes a protein:
Function:
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA.
Sequence:
LLSVRPLALWLCQLSCGLNTDRTQGDPLPRALVELVQSSSINSIEDLRRLLLTDSVEDDPDSPASGGALSNSTFSRLPRSLMLEAEPAVQAQCKVRTEVMAITRGMVDRRNANFLVWPPCVEVQRCSGCCSLRGQRCLPTAVHLRHLQVVKIEYVNKKTNYGRAVVSVEDHLACRCASTADVPRAAPREPQHQARPRQPESRQPETPQPQLEEEQHLHRRQPEEHHRHQKQQHQEQQQQPEEHHKQQHHQDQQHPSNRTTTHRPGNPP
The following text describes a protein:
Function:
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Subcellular Localization:
Cytoplasm.
Sequence:
MKFGVVARRDKLEALKLAYRVYDFLKVSGFDVVVDEDTYRYLGEFSEDDVLPLEEFDVDIIVVIGGDGTILRVEHKTKKEIPILGINMGTLGFLTEVEPHETFFALSRVIEGDYHIDERIKLRTFLDGENRVPDALNEVAVLTGIPGKIIHLKYYIDGGLADEVRADGLIISTPTGSTGYAMSAGGPFVDPRLDVVVIAPLAPIALSSRPMVVPSSSRIDVRNVAMTREVILSVDGQFYTYLSPETEITIVRSPRKTKFVRFNREIYPKYTMKIKSRF
The following text describes a protein:
Function:
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.
Sequence:
MSAKNNIQDQLLNTARKDKLDLTIYLLNGVPLKGKVVSFDNFTIVLEQENKQSLVYKHAISTIIPAKIIKLYTEEAKDNKDAAQG
The following text describes a protein:
Function:
This protein is involved in the repair of mismatches in DNA.
Sequence:
MSTVKPIDANTVHKICSGQVITDVASAVKELVENSLDSGATTIEIRFKNYGINSIEVVDNGSGIDAGDYESIGKKHFTSKITDFEDLEALQTFGFRGEALSSLCAVGQVIISTATQNEAPKGVQLNLDHEGSLKDKLTIPFQRGTSVMVNDLFCTLPVRRKLLEKNYKREFSKAISLLQAYATISTNKRFMVYHQTKNSGKLLQLSTNSNKDMKLNIMNVFGTKVSSSLIPWNDGIIEGYISRPHVGSTRASNERQMLFINRRLVNLPKIARVIQEVFKPYSMAQSPFFAINLRITNGTIDINVSPDKKSVFLSEEDSIIEFIKNSLQNLCESCGHAISCSRSQSIFSYSSQIPDSSGDSTDQELPQSIPATESETSDDSSFSYKRSPCKRKLVEATAQPAISTSVAEGASLAQVSKPLPERLQKDSMRRSSPLNEKVTASSERMKKKLALFASSTDTSMQKTIDSSFPLKQPINKPSSNPNNLLLNDPSPASTPVAKTINLNEIESVHNAESVSTLSSIPRTEQTSVANRIPSKTAALQKLKFFQSRPLDGLNKFSKKINISLSGVQKDIVRSDALLKFSNKIGVVHDISDENQEDHLNLTVHKADFLRMRVVGQFNRGFIVVVHGNNLFIIDQHASDEKFNYEHLKSNLVINSQDLVLPKRLDLAATEETVLIDHIDLIRRKGFGVAIDLNQRVGNRCTLLSVPTSKNVIFDTSDLLEIISVLSEHPQIDPFSSRLERMLASKACRSSVMIGRALTISEMNTIVRHLAELSKPWNCPHGRPTMRHLLRLKDI
The following text describes a protein:
Function:
Putative phospholipase.
Sequence:
MKLVIILLTFLHVTESSPYQIASVVIGKNDSLSIKAGYIEPNVAWARFRDEINQTGWSYLEVFSNESYSDVLQATAAGMAEGFITADLIHMDYMNKYADYCKNDENFCKKLTEYLRGNEAWRAKMIKSHLNESYWYQVQLIDAQVEGIKKGYHNKSLALPEIPDLAFFFFQASGDLEDLEVALKKENPSRILGSGSCSALVKVLPEHKDIFISHVTWDTYLGMLRIFKMYDFPFTRKGRKDLRVIAKRVSIETTIGNTNEDLWKYVTPQGTLLEWVRVMIANRLARTSDEWTFLFSKHNSGTYNNQWMVLDYKLFTPGQPIQPGTLSVLEQIPGMTETADMSVYLQENGYWASYNLPYFPTIYNMSGQEASREAYGSWFDYHLNPRAQIFKRDQSKVVDLETMMKLMRWVNCNRTLVKKCHSPPPPLTFDSTKEDDFLGCALVFAALPSHCFHPQITSFELFQKFQCIAVSGPTHDQQPAFQWSTSEWEKPLGHPDKFDFEPVKVSWDNKD
The following text describes a protein:
Function:
In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
Sequence:
MIRLNDILDKVVTYNPVADLDLIRKAYVYCAKVHQGQTRLSGEPYLVHPMEVAGVLADLKLDVPTVVTGLLHDTIEDTLTTREELEGMFGAEVANLVDGVTKIGKIHFKTKEESQAENFRKMLLAMANDIRVILVKLADRLHNMRTLQYQPEPKQRSISRETLDIYAPLANRLGISWIKSELEDLSFRYLEPQIYYDLASKVAKKKKERESYVEEVRQIIVSKLAEHDLKGDVFGRSKHLYSIWRKMQARNVDIDQIYDLVAIRVMVNDIRECYEVLGIIHSTWKPIPGRFKDYIAMPKGNMYQSLHTTVIGPHGERMEVQIRTSDMHRVAEAGIAAHWKYKEGKGYDEKEVKRFAWLRQLLEWQQELQDSHEFMNTVKVELFPEEVYVFTPRGDVKSFPKGSTPIDLAYTIHTDIGHRCVGAKVNGKLVPLKYELKNGDIVEVITSPHHTPSKDWLKIVKSSRARNKIRAWIKTEERVRSISLGKEILEKEFRRYSLNLAKLQKAGEIKRVASEFGLSTDDDVMAAVGYGKLSANQVIGKLLPEEKLQERQEQKESRIGKMIGKLTGSSPSAIQIGGVDDVLVRFGKCCNPVPGDDIIGFITRGRGVTIHTADCPVALENDPERRIAVTWNRERKAALPVKIRVSCHDQKGILANITQAITDCEANISSASIQSTVDKRGVNIFEVDVTDLDHLKRVMNNIMKLSGVISVERMKN
The following text describes a protein:
Function:
Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
Sequence:
MLNEQQITRLLYRLQDPVLEASLEETEGVLEVQVLEETANIKIALADPAVETDHFVHNIEELLTQFGVNEINIELEYLPAAVIDRIFQARDNILSEASETKFLAIASGKGGVGKSTVSANLAIALAQQGKKVGLLDADIYGFSIPVLLGTTESPHKENGQIIPVETHGIQMISMDFFVEQGEPVIWRGPMLGKMIKMFLEEVRWGKLDYLLIDLPPGTGDVALDIHTLIPKCNELIVTTPHYAAASVASRAGYMAAKNNHKIIGVIENMSYLTLADGQVLKVFGQGGGEKVAADLETQLLIQLPIEQPEPNGNGYVSALFNSSSTSGKAYKTLAEKIIPYLS
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MASLRDIKAKINSTKKTSQITKAMEMVSASKLNRAEQNAKSFVPYMEKIQEVVASIAQGSKGINHPMLNARPVKRTGYIVITSDRGLAGGYNSNVLRTVSNVIRERHNMDSNQYSIIVLGRLGRDYLKRRGFNIIDEVVGLSDHPSFTDIKDLASRAIAMFADGAYDELYIYYNHYVSKISQEVTENKILPLTDVASDKPTTAYEFEPSEEEILKVLLPQYAESLVYGALLDGKASEHAARMTAMKSATDNAMEVIDSLTLSFNRARQAAITQEITEIVGGAAALE
The following text describes a protein:
Function:
GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1. In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity. Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation. In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation.
Subcellular Localization:
Cell projection, dendrite. Cell projection, dendritic spine. Presynapse. Recycling endosome.
Sequence:
MALWRRKLQISSRRKRRAPPEAEKTEVLSDDLLQVEKRLELVKQVSHSTHKKLSACLQGQQCVEVDKRSVRSPSKKLPLTSLAQCLVEGAAVLGDDCLLGKMLKICGEAQDSLAQELLLFELQIERDVVEPLYTLSEVEIPNIQKQRKHLAKLVLDMDSARTRWHQSSKSSTLSNKETPTGAKADALREEMEEAANRMEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLELLQSVLPQIKAQQESWVEKPCYGKPLEEHLTLSGREIAFPIEACVTMLLDCGLQEEGLFRVAPSASKLKKLKASLDCGVLDYQEYSADPHAIAGALKSYLRELPEPLLTFDLYEDWIQASNIADQDKRLQALLSTCEKLPVANSNNFKYLIKFLAKMNEYQEYNKMTPGNIAIVLGPNLLWAHAEGDITEMMTTVSLQIVGIIEPIIQHADWFFPGEIDFNVTGNYGSPVHTNHNANYNSMPSPDMEPSERRLQDQSRRPLSVATDNMMLEFYKKDGIRKIQSMGVRVMDTSWVSRRGSSSSRKSSSTPPSVHPPAPPYDSLNPDQSADFSTSPSQTPPPISCDRTSLVEASSNWPDSSHVCPSPEEERPPPPYPFSSMSSFSSSFSSFSLPHARPDGPPPVFTRWSVYSPPPPLLSSTSLDINSNPKPCSLQLSKQGSLPAEPSHPHPPPPVYIKPPLGLPRHEPSLGQPRDRALRVMRKEPSPVIGQRGISPTAPPAGHNLLSDQSPHTLRKVSKKLAPIPPKAALCGCEVSPSASPASLSPTPPSTPSSYSFSYSQSCVLTSPGHTHAHTPPALASPPPLTGTLPKNRPTPKPPRHRPSLPPPPQPPDALTPAESMSTAV
The following text describes a protein:
Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC.
Sequence:
MEEADRQLLRRCRVRLVRELQVAELWDALLSRELFTRDMIEDIQRAGSGSRRDQARQLVIDLETRGRQALPRFISCLEDTGQGSLASFLQSSGQAAKQDPEAVTPLDHLVPVVLGPMGLKSKEQKVVKLDPSQPALGNLTPVVLGPEELWPTRLRPEVLTPETPRPVDIGSGRAHDVCTPGKIERHADMAYTLDSDPCGHCLIINNVNFCPSSGLSTRIGSHVDCEKLQHRFCWLRFMVEVKNDLTAKKMVTALMEMAHRDHRALDCFVVVILSHGCQASHLQFPGAVYGTDGCSVSIERIVNIFNGTGCPSLGGKPKLFFIQACGGEQKDHGFEVAFTSSQDKAFDSDSEPDAVPYQEGPRTLDQLDAVSSLPTPSDILVSYSTFPGFVSWRDKKSGSWYIETLDGVLEQWARSEDLQSLLLRVANAVSEKGVYKQIPGCFNFLRKKLFFKTS
The following text describes a protein:
Function:
Histone methyltransferase.
Subcellular Localization:
Nucleus.
Sequence:
MTVKRKTNHKEIKEEIDRENWFITSKKQKTLDVFGRGFRDFSFQLNVKESKLPNFLPPVQDYPFSAESKDRTPSPRSHLFPEYSFKLRKINICCSACKKISSNLNENSLCPDCKAKSDPPQISNSLSLPQENIAVICNGMEGIYFPALHMVQCKCGTCSIKKQKVGEWEKHAGSRAKKWKASIKVKISMQPLGEWVENQNTHGFNPLKLDRQQLISLLQEKYKPVNAKWTSERCAICRWIEDWDFNKIIICNRCQIAVHQECYGAKGVRDFASWVCRACETPQVDRECCLCPVKGGALKPTDVDPFWVHVTCAWFRPEIAFVNVEKMEPAIGLLAIPPKSFHQTCSICKQTHGSCIQCCKCALSYHTMCAFRAGYYMEMHCSGKNGTQTTKWLSYCASHKAPSVDNVLVMRTPNGVYSNQNMLHGINGGRVLKGLRVLMPSEASSTETNEPDPFSAARCRVFRQSTNKKVKPEPILHRLTRPHHHSLKLIHSLSSKQFQEERNFPTLRERLHHLNRTINHRICFGKSGIHGWGLFAKREIQEGEMVAEYVGERIRGSVADLRERRYRSQGKDCYFFRINEEVVIDATMKGTIARLINHSCMPNCFARIMSLGEEEDRIVLIAKTDVSAGDELTFDYRFEADQSDELKVPCLCGAPNCRKFMN