lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces.
Sequence:
MGLPGALYPSPRFPWGRNRPTCTGARSVGVLLLMVCLWGAVYPHSVELRLVSDHGRCAGRVEVLHNGIWGTVCGDNWDAHDGQVVCRQLSCGTVLSVSRGARHGEGAGPIWLDEVNCTGTEAALSECQARPWGQHDCVHMEDASVECSESHISKIGRLQLLDGPSRCAGRVEVLHDQRWGTICDDGWDLADANVVCRQLGCGTAVLATKAAHYGRGQDTIWLDEVNCTGMEESIFDCKASAWGVNNCYHGEDAGVLCSDSGVPISVELRLVNGSTHCNGRVEVFHNDTWAALCDHGWGMAEAQVVCRQLGCGEALLAPVGSHFGQGSGQLWPGNINCTGSESALFTCKTKQWSNSTCHPWTSAGVVCAEGDQVRLVNYRSRCAGRVEILHNKRWGTVCDKNWDLLDANVVCRQLGCGRALSATGQAQFGQGSGIVWLDGMNCTGFEHSLSSCLAKPWGITTCDHWADAGVVCSDSIIPEPAHLRLVNGSHRCAGRVEVFHKEMWGAVCDHGWDKMDAEVVCRQLGCGTALSASGEAHLDAASLRVWLDNVSCEGTELSLTKCRASPWGKSSCSHGKHASVVCSGSVVSSFAPIRLVDGPGLCAGRLEVFHNEQWGTVCDDSWEFTDAAVVCRQLDCGVVISAPPRAYFGQGQGPMWLDDVNCTGTEAALSECKFKGWGIHNCYHHEVASVVCSGSGISDLADLRLVNGSDKCSGRLEVFHDQRWGTVCADDWDLAEAYVVCRQLGCGTPRSASNSSQFGEGPHLTWVDAVECTGMERALFECKVKLWGAQNCKSKGYASVVCSEAVDIDLRSPEAIRLVNGPHRCSGQVEVFHNQQWGTVCNDDWDLNDANVVCRQLDCGTAVSLRRPSSGQDSRPIWLEGVRCLGTEATLTECPVKPRGLYSCSHLEDAGVVCSGPRISNISTLRLVDGLSECAGRVEVFYNNEWGTVCDDNWDMSDAAVVCRQLGCGTALSAPGSARFGWGYSRIWLDEVSCTGEENDISQCAAKTWGVHNCHHGEDAGVVCSGNLSSADVRLVNGPSRCAGRVEVLHNGQWGTVCDDGWDLNDAKVVCRQLGCGTVLSAPVRAYFGQGTGDIWLDDVSCTGIEDALPHCQARPWGQHNCNHREDAGVVCLVTDTSKPNFLRLVSGPNRCAGRVEVLHDGQWGTVCDDGWNLQAATVVCRQLNCGRAESAPSGARFGQGTGRIWLDDVNCAGTEDALHQCRARPWGLHNCNHREDAGVVCSDSQLEITAKVRLVDGPHRCAGRLEVFQNERWGTVCGNGWDMNDAIVVCRQLGCGIALSAPVQAHFGQGSDPIWMNRVSCIGTESSISECLSSPWGIQLCTHMDDAGVECSALSDDTSTLRLVNGPHRCSGRVEVFHNQQWGTVCDDGWDMNDAMVVCNQLGCGEALSATTQASFGRGADPIWLDRVACTGRENTLIQCRARPWGVNVCTHEEDAGVVCSDKNITVEAAEIRLVNGPSRCAGRVEVLHNGQWGTVCDDGWNLQAATVVCRQLNCGRAESAPSRARFGQGTGRIWLDDVYCAGTEDALHQCRAHPWGLHNCNHREDAGVVCSENHTFPAAEDSNTTEEMQIRLVNGPNHCAGRIEVFHNGQWGTVCDDSWNLRSAKVVCRQLGCGTAVSAPGKAHFGRGSDPIWLDDVECSGTEASLSQCRLNNWGNHNCNHEEDAAVVCSGTNPLQVRLRDSSSPCAGRVEVRYNATWYSICDKSWSSLEAEVVCKQLGCGPAQAESAGTRISQNHNYIFLEGLQCRGAESLFLECQQNKIGPGLCQHGVAASVVCTEPRGSPSSCSALITLLTLMVMVSGVLLWLYLKSRCTGAAQAADLRCPREQGASAMPFQTAGAIYHPTEGQFHKDADTETTELIREDALL
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MASLKDMRVRIASTKATQKITKAMQMVAASKLRRAQTAAEAARPYADKMSAVISNIAGAAAGSPGAPALLAGTGRDQVHLLLVCTGERGLSGAFNSSIVRLARERALALMAQGKEVKFFCVGRKGYEQLRRQFDKQIVEHLDLRSVRQLGFVNAEDIAKKVLARFEAGEFDVCTLFYSRFRSVIAQIPTAQQIIPLVVEEGTAASTTSYEYEPEEDEILTRLLPRNLAVQIFRALLENNASFYGAQMSAMDNATRNAGEMIRKQTLVYNRTRQAQITKELIEIISGAEAV
The following text describes a protein:
Function:
Together with methyltransferase Trm7-32, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs (By similarity). Plays a key role in energy homeostasis by regulating the balance between energy storage and heat production. Functions by negatively regulating Ca(2+) signaling pathways that are involved in heat production and maintaining correct lipid storage in the fat body. Regulates Ca(2+) signaling pathways by reducing the activity of the calcium-transporting ATPase SERCA possibly by promoting uncoupling of SERCA ATP hydrolysis from calcium pumping. May also function in the nervous system to control feeding behavior.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MNDLNLRVAALKVCAHPKRFAELRDALVPLPNTWIAAPHDFVLQFAAAKSSAEQVQVVKDVFYGEQAQDHEDVAHFLADLLLASPLKHAVRNQLTKLFSDNALAKQNASPHRRHSKEHLLEALQQSLGEMANSLAVITPPVSHERTNDVFVSANACLQNFPFGREALGKQVHRFAPLLTTALERYWADICDPTLELSPTRRNELYLYVQNALRFLVSLLAEWSDKLRLFEDQRFPGTSNAVAQKVARYYDTPWDVRSIAALLIGHLARFSGTFKAYVEDCSRPKAEQDVPIQMAALLVLRPVDYTENATLALAILKRIVAVSELKSTVTNLLVFLSKHLFIYSKSLGEMHAHLPDDQKLLYQRILAQLQVFALQNISSDTDSVRHMSSALLHQVLQHAQAAGQEELFQVVYRQFEDRAAYLNASCMALEQLVAVAGVSKSIENCPSLFGVIFPRHLGCEDCVDALFKAMMVSAHKTEPFAEWQSRWFGLLLAAIRVPEKRRQVIEELIAQAVQLEPTRLAQVLLPDDRLPLSCKLAAILGVRQLSARRQNLLRGMKEEVEQALIGLDDHTRLLALRFLVETPRPSELLNADQMGAIELYVRHNANNPSAHLRQLGYGLLQKALKRVHFGLVEYRKSRTPASQEVLQFLIRLIRTLAQNLFPTANYGRRWLSLRLLRDCLELSEMVGITFSELGIELPTEALMACLGDSYEHNKVLAAQLLERFQSHSLFKPDEMIELLLSLRPSDSATGAFQLQVYCKASRVQSEMPTPTHGGTIHEPLTFRALQWCLQHLREGLRLAQLDLGEAAKLNPLYGLLFASRHLLQQLKLKELAKEPQWRQYIDELVTMCLAVSSVVLPVVSSASPEGHLPETCDQETDQPLTNVLDRQLSREELLQVRTTPQMILLCAWRSSKEVCLILGELVQRAPLEEEEDEEQQQQQGDFLLSRAQLEAIGEHFLQLLAETKHRGAFEQAYVGFTMLCRRFWHSESVRLNQLPGQWVDEAMAMVSGQEEWAGKGARLCATRRSAGMPFMLQALVGTELKLGTHATLYRCMNRLLEVCERRTGGAAGITARSHALNIMRALFRSSELAELVTEFMARGIQCALDGLLLAEEWAERNSATLLLAALIVRVFGVERARLETGELHVRNRMTGRIFFTRYPQLFDYFHAALQRESEQMDAGGGGSENASGKRRQAVQLEAMLLMLSRLYPSSLEGAESTLNLSEFVPFLIRICHSHDLMTREMAALVVANFVTQEQALAEIRRIVVELKALQLRLKNTEAANTKLNTNVLHGQLLLLLHLHRLVRWTRPSLTRMQLHTLAELAAPLLQHDACAFSALVAVMVAAMEDAVEPGLLDFQLLEQIGVVYLLNHKEVQSRCQQLGISNRFYQIFGLHLHRLRGISQGIVLHIVEDLAETIWALDELKVELWLYILLQRSLSEQNSLVSEQDIEHFEFSRDIRRYFETLSREQREEVGQELYESPAVRSSVLHMMHMIKSSKNSCWSLQLAGRLAALQTLLRDPGLELNQLVQRCSEEHSTHQEAGLLLGLRRLIGESKMLERKHWLPMLNYAQRLVHPGQPVYLRHQAAELCDSLARNHLRDQLVAGTTDVDIGLVGRFSGLVLLLLHDDAEWVRHRAVQLVCGAGLRTRSGAGQEQEQSAMAPLILPSALIPPFLDTMIGKLTFDDFNMVQRLVDIIAEPFTTADAMELFDKQENNHYCERNHVLTELWDARGRADPRARTPTIPTGYQIFK
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MRINTPIQQTMTRRLAPSMLIFIALVCSAMRCEAAGPDQSKNAAELTALCEFIKLTEADMSALSDEEIDTNDLTIMEALNMTLADPNWSKQFSDDASKPTDEPVPCKGKAATDPCKSHWKKWETAKVKAKDNNIRPDKLKLEEVKLTSSYGRSAALQVASLLEEAEKLKKNWETNHKAHVTGLKAAVTTLLNKAAYNVDPVPAQSNHKCNVKVDTSRQKTCELPKAGEAICGALVCICAKGSTQSKDICGDSSTPNLSDWSSGNMKTHYATYDSICKKNKQIKLTAEAITKRLAALKRLYRDVGNAGGRAVILGTKTDDNTCKDHAGTACIDLTKATASTSEASATEIGWEQKLQEAVDKLNAAEQAKAHRDTTQRQITSMRRQVEAIFKQVAIAPAGTLTAATQPGIAPAQPSITTAGPRLCETFNGNESGCTGAECNYDKVKSECKPKAVEGTTGKARTGEATTEKCKGKPEKDCKDGCKWEGTECKDSSFLLKKQFAPIVSDFVDL
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Membrane.
Sequence:
MLSILEYNSFLLSPLIASSAPLVAYPIPGTAAPVSRGPEKFIGHESGMEPTGDTRTKFQIRYYMFAPVPVILDVETVFPHPWATSFNELGIFASIEAFTSVTIPVVGSVYAWRKGALEWSQ
The following text describes a protein:
Function:
May act as an effector for ARL3.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm. Nucleus.
Sequence:
MAAEEDEVEWVVESIAGFLRGPDWSIPILDFVEQKCEVFDDEEESKLTYTEIHQEYKELVEKLLESYLKEIGINEDQFQEACTSPLAKTHTSQAILQPVLAAEDFTIFKAMMVQKNIEMQLQAIRIIQERNGVLPDCLTDGSDVVSDLEQEEMKILREVLRKSKEEYDQEEERKRKNQLSEAKTEEPSMHANETVKMNNSQGDGEHFAHPPSEVKVHFANQSVQPLTTKLEMLPETSTLPKKGLKIPGFERASIEGPIANLSTLGTEELRQREHYLKQKRDKLMSMRKDMRTKQIQNLEEKGTPVGELEEMTEKPEMTAEEKQTLLKRRLLAEKLKEEVINK
The following text describes a protein:
Function:
Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.
Subcellular Localization:
Cytoplasm. Peroxisome.
Sequence:
MLSEVLLVSAPGKVILHGEHAVVHGKIALAVALNLRTFLRLQPHSNGKMCLNLPNIGVKRAWDVARLQLQDTSFLEPGNATGDAAAPTSEQVEKLKEVAGIPKDGADPECLAVLAFLYLYLSICRKQRTLPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEAIPNPQNNGESASRWTMEDLELINKWAFQGERMIHGNPSGVDNTISTWGGALRYQQGKISSIKRLPALKILLTNTKVPRSTKALVASVRSRLLKFPEIVAPLLTSINAISLECERTLEEMASAPAPEHYLVLEELIDINQHHLNALGVGHASLDQLCQVTMAHGLHSKLTGAGGGGCGITLLRPDLEQPKVEAMKQALTSCGFDCWETRIGAPGISIHSAASLDTQVQRALDGL
The following text describes a protein:
Function:
Transcriptional activator required for anther and post-meiotic pollen development and maturation. Seems to regulate inflorescence branching and floral development. May control tapetal development by directly regulating tapetal programmed cell death (PCD) and breakdown. Implicated in pollen cytosolic components and wall development (e.g. exine and intine formation).
Subcellular Localization:
Nucleus.
Sequence:
MANLIRTDHQQHIPKKRKRGESRVFRLKTFGESGHPAEMNELSFRDNLAKLLEFGHFESSGLMGSWSFQLEIQRNPNPLYVLLFVVEEPIEASLNLRCNHCQYVGWGNQMICNKKYHFVIPSKETMAAFLKLEGGGYAFPEKESFSHLVELQGHVLHGFFHSNGFGHLLSLNGIETGSDLTGHQVMDLWDRLCTGLKARKIGLNDASHKKGMELRLLHGVAKGEPWFGRWGYRFGSGTYGVTQKIYEKALESVRNIPLCLLNHHLTSLNRETPILLSKYQSLSTEPLITLSDLFRFMLHLHSRLPRDNYMSNSRNQIISIDSTNCRWSQKRIQMAIKVVIESLKRVEYRWISRQEVRDAARNYIGDTGLLDFVLKSLGNQVVGNYLVRRSLNPVKKVLEYSLEDISNLLPSSNNELITLQNQNSMGKMATNGHNKITRGQVMKDMFYFYKHILMDYKGVLGPIGGILNQIGMASRAILDAKYFIKEYHYIRDTSAKTLHLDRGEELGIFCTIAWKCHHHNNEIKVPPQECIVVKKDATLSEVYGEAERVFRDIYWELRDVVVESVVGGQIEITRVDEMALNGNKGLVLEGNVGMMMNIEVTKCYEDDDKKKDKRIECECGATEEDGERMVCCDICEVWQHTRCVGVQHNEEVPRIFLCQSCDQHLIPLSFLP
The following text describes a protein:
Function:
Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.
Sequence:
MPVLAGGAESEAGIPKAPSDERRPGAMEELEHTCPQPRLTLTAPAPFADETSCQCRAPHEKLTIAQARLGTPVDRPVRVYADGIFDLFHSGHARALMQAKTLFPNSYLLVGVCSDDLTHKFKGFTVMNETERYEALRHCRYVDEVIRDAPWTLTPEFLEKHKIDFVAHDDIPYSSAGSDDVYKHIKEAGFLCPFSATCRSAWSCRAFPAGFLFPLCSGMFVPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYRFQNQVDKMKEKVKNVEEKSKEFVNKVEEKSHDLIQKWEEKSREFIGNFLELFGPDGALKQMFQERSGRMLQAFSPRQSPTSSPTRGRSPSRSPSPPWVFNKSSPPSSPKAASASLSSMSEGDEDEK
The following text describes a protein:
Function:
Extracellular zinc metalloprotease.
Subcellular Localization:
Secreted.
Sequence:
MLSSSTPHRRTSHTTSHTSRRTAHRRAAAVALAGVAALIATAVQSGTATAAPDPSPAKGNELVRLSPAQRAELIRDADATKAKTAGELGLGAKEKLVVRDVAKDRDGTLHTRYERTYDGLPVLGGDLVVATDAGKTEQVVKATAKALRPATVTPKISAAKAESQAVSAAKAAGAEQPDADRAPRKVIWAASGTPVLAYETVVGGLQEDGTPNELHVITDAATGAKLYEYQGIENGTGNTLYSGTVTLGTAQSGSSYTLTDTARGNHKTYNLNRGTSGTGTLFSGSDDVWGNGSASNAETAAADAHYGAALTWDYYKNVHGRSGIRGDGVGAYSRVHYGNNYVNAFWQDSCFCMTYGDGSGNANPLTSIDVAAHEMSHGVTSVTAGLNYSGESGGLNEATSDIFATAVEFYANNSSDVGDYLIGEEIDINGDGTPLRYMDKPSKDGASKDSWYSGIGGVDVHYSSGPANHFFYLLSEGSGTKTINGVTYNSPTSDGLPVTGIGRAKAEKIWFRALTTKFTSTTNYAGARTGTLAAAGELYGTDSAEYTAVANAWAGINVGARPGGGDPGDGTTFESTTNVNIPDYGSAVTSSLTVSGRTGNAPSNLQVGVDIEHTWRGDLQIDLVAPDGSTYRLKNSGYDPAEDVHETYTVNASSESANGTWKLRVQDQGPADTGYIDAWRLTFP
The following text describes a protein:
Function:
Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The DPH-type metal-binding (MB) domain can bind either zinc or iron ions.
Sequence:
MNHYSVLNLKDGKTYTDDEIKEAYRKALLLFHPDKCKEKPSVVYTIDQVKEAYQVLSSEKDRQQYQIKQEEESSHYYSIVDLSEFEELDNGSYYYPCRCGDLGGYVVTEDDLENNRSVVPCMGCSLTIQVDYEIAESDS
The following text describes a protein:
Function:
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.
Subcellular Localization:
Cytoplasm.
Sequence:
MYALEDYHGRKNRNILISKEEIEEKITEIGEKISKDYKDKNLYILSLLRGSFIFAADIVRKINVPTKIGFMTTSSYGHKEQSSGNVKIVNDIPDDIKGYDVIVVDDIVDTGITMEFVMNHVKSLGANSVKSCVLLDKPERRKVNLDPDYSCFTIPDVFVVGYGLNYGDYYRNIPYVFNWKE
The following text describes a protein:
Function:
Responsible for physiological and behavioral changes in mated female flies.
Subcellular Localization:
Secreted.
Sequence:
MYASNLLYLLALWNLWDLSGGQQDIPNGKATLPSPQTPQNTIDQIGINQNYWFTYNALKQNETLAIIDTMEMRIASSLLEFKAQMEIQLQPLKIIMRHHASNIKASNNIKMRRFEKVGSRHFHIEKNLMQTWFEAYVTCRKMNGHLANIQDEMELDGILALAPNNSYWIDISKLVENGGTFVSTLTGREPFFVKWKSNQDTKKKNQCVYIYAKEMSYDECFEKKSFVCQADQWA
The following text describes a protein:
Function:
Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8 (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with R-SMAD. PDPK1 prevents its nuclear translocation.
Domain:
The MH1 domain is required for DNA binding; The MH2 domain is required for both homomeric and heteromeric interactions and for transcriptional regulation. Sufficient for nuclear import (By similarity).
Sequence:
MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSGMLVKDEYVHDFEGQPSLATEGHSIQTIQHPPSNRASTETYSTPALLAPSESNATSTTNFPNIPVASTSQPASILAGSHSEGLLQIASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYPPNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTMPIADPQPLD
The following text describes a protein:
Function:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May play a role in the regulation of cell proliferation and autophagy by promoting the ubiquitination and degradation of SQSTM1.
Subcellular Localization:
Cytoplasm.
Domain:
The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
Sequence:
MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGASCWSGFHIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQLPENFDIHPVGSLAEKIQALHFSLRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEHSGSVEDDI
The following text describes a protein:
Function:
Functions as an E3 ubiquitin ligase.
Sequence:
MVLPWRSRGGVAKRRNQLISGDISVVETKIPVQLRSPSRIERIQSPRVLLTPRDAVEISRRLQNAAAREEYAECLEIVSKIKNLGRGGDTNKKCLVQNGSVLALSSCFERFAAARDGHMRLLEEILFVLSSWLPLNRSEGFNKMGSTASLNCLVRFLNGKDAKTRQNAAFCIREVIAVDKRYVYALTDVEGACEGLVKIIRDSVSTSSTKASLMVIYRAISSNDKITEKFVKLGLVELITEMMVNNAEKSVCERSLVVLNATCDNEQGKEDVLRNALIVPLLVKKILRVSDLATQCSVSILWKLWKNKKDGECDDRLLVEALQVGAFEKLLVLLQVGCEDKTKEKASELLRNLNRCRNEIEKTNCVDSSMHLKNVKKSF
The following text describes a protein:
Function:
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).
Subcellular Localization:
Cytoplasm. Nucleus, gem.
Sequence:
MAAAFEASGALAAVASAMPAEHVAVEVPAPEPTPGPVRILRTAQDLSSPRTRTGDVLLAEPADFESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLVLENLSTQILILAPTREIAVQIHSVITAIGIKMEGLECHVFIGGTPLSQDKTRLKKCHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGSFQEQINWIYSSLPASKQMLAVSATYPEFLANALTKYMRDPTFVRLNSSDPSLIGLKQYYKVVNSYPLAHKVFEEKTQHLQELFSRIPFNQALVFSNLHSRAQHLADILSSKGFPAECISGNMNQNQRLDAMAKLKHFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDWETYMHRIGRAGRFGTLGLTVTYCCQGEEENMMMRIAQKCNINLLPLPDPIPSGLMEECVDWDVEVKAAVHTYGIASVPNQPLKKQIQKIERTLQIQKAHGDHMASSRNNSVSGLSVKSKNNTKQKLPVKSHSECGIIEKATSPKELGCDRQSEEQMKNSVQTPVENSTNGQHQVKEALPVSLPQIPCLSSFKIHQPYTLTFAELVEDYEHYIKEGLEKPVEIIRHYTGPGDQTVNPQNGFVRNKVTEQRVPVLASSSQSGDSESDSDSYSSRTSSQSKGNKSYLEGSSDNQLKDSESTPVDDRIPLEQPPNGSDTPNPEKYQESPGIQMKTRLKEGASQRAKQSRRNLPRRSPFRLQTEAQEDDWYDCHRETHLSFSDTYQDYEEYWRAYYRAWQEYYAAASHSYYWNAQRHPSWMAAYHMNTIYLQEMMHSNQ
The following text describes a protein:
Function:
Heme receptor.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MNILINKRIFLLVTLVGIQLNVTAKQNSSNSNREELLPIIVNTNDDSNKLPGRSVLKQKNIEQXQADNAANLINILPGVNMAGGFRPGGQTLNINGMGDAEDVRVQLDGATKSFEKYQQGSIFIEPELLRRVTVDKGNYSPQYGNGGFAGTVKFETKDARDFLQENQKIGGFLKYGNNSNNNQKTYSTALVLQNEQKNIDLLLFGSVRNAGDYKRPDNSKILFSKNNQKTGLIKLNWQISPEHLLTLSSVYGIHKGWEPFAAKRDILPKPSLSDIMRYGTDIAWKRKLVYRDQKDENYTLKYNYLPENNPWINLSTQFSYSKTTQNDMRPKEASSGLVGSLGNQSWITYSDLTFDINNTSTFNIKTTVHELLFGLQWLKNTRNTLMYDKSKVRKADYNYGYFQPYYMPSGRQYTQAFYLQDQIKWKNIIFSTGVRYDHINNIGQKNLALKYNDISAGHDYSQKNYNGWSYYLGLNYDVNHYLSLFTNFSKTWRAPVIDEQYETQFKQSSVPATSLNLEKEMINQTRVGGIITLNHLFQENDAFQFRTTYFYNRGKNEIFKTRGVNCVGNAADTNNKVCPKIIENYRNLPGYVIQGAELEAYYQSTYLFGEITYSYVKGKRDTSPRNPWGKTSTWIAEIPPRKATTALGFNVPKYYLTVGWRAEFVRRQDRSPLSGDPKASSWSLPASRGYSLHNLFLSWSPAKIKGMNVKITVDNLFNRAYNPYLGELASGTGRNIKFSLSQKF
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVKATTASPLLAGTQLDLKSYVKEFRKHTKHPENFMKVQKPLAKKLKQFVKEIYDRGTKNATVTQDGPALPYLDELVTEEMDDEQIWQQLELKNDHFIDQDLKKFLEVVSKNEKRLQLPFTTKTQSEMGDDSGAGSSGEEMEMEDSDEENEANGDGMESEEEEDEQDGEEMDSDEELTKKKSKKLKKKDKNGKQKKKQPKGKKSVVDDRFFKLDDMARFLDEEDERERRRQYGLAEKNPLIEVDYFDEHTGEDDGDISDLKYSDFFEDEEDEDDDTDEDDEEEEKDDDAEEEEEDASAAEEEDEDEDDEDDDEDESPDGQKDEEEGELSDEAEMERNRKLRYEIYKGENGMSPPRSEKPPKKAVIDQPDTSDSEEEKAPDGPKSSYELRQEKLKEKISKMEAGMLKDKPWQLKGEISAETRPKNSLLEEVLQYEHTTRPAPVVTEDTTMRLEDIIKQRIRNKAFDDVERKVRPPDNPREYRKQLVLDGEKSKLSLAQVYEQDYLKQLELANPDAAAQAGEEEEPKEHKEIRSMMKVVLAQLDALSNFHYTPRPAVPELKILTNTPAISMEEVAPVATSDATLLAPEEVHRRPKGDVMSKDERTKTDQNRERRLKKRFQREKYRRETEREQRQLEKASASGMAKQNRALQTSLLKKVTKAKNVQQMAETSTGPSKSSTAFFSQLQDEVRSQVKAKTDGTKKKKKNTENLIASNFKL
The following text describes a protein:
Function:
Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May regulate haploid genes important for spermiogenesis.
Subcellular Localization:
Nucleus. Cytoplasm. Note=In step 9-11 spermatids, shifts from nucleus to cytoplasm.
Sequence:
MEFVSGYRDEFLDFAALLFGWFRKFVAERGTMGTSLEGRWRQLESQIRRLPQDPALWVLHVLPNRSVGISLGQGAEPGPGPGLGASRLLGDEPPLHLRDLSPYVSFVSLEDGEEGEEEEEDEEHGERPGMEKVEPQEGGEPAPPSKRFPQEAKPAPESEVTQQEASREEGSREERPEDERAPEKRKGQKNAEAAPLHLSCLLLVTDEHGTILGIDLLMDGAQGSVGQNPGTENLAPRAYALLCHSMACPMGSGDPRKPRQLTVGDAHLHRELESLVPRLGVKLAKTPMRTWGPRPGFTFASLRARTCHVCHKHSFEVKLTPCPQCSAVLYCGEACLQADWRRCPDDVSHRFWCPRLSAFMERVGELASLPFTYTAEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGAPRYPWGSTSSLSCLLNGDPYQLLQGDGPALMPPVPLEPPRSLFGSWQDYYTWRGLSLDSPMAVLLTYPLTVYYVITHLVPQSFPELNIQNKQSLKIHVVEAGKEFDLVMVFWELLVLLPHVALELQFVGDSLPPESDQQHFTMQRDGPEVSLRPGSGVSARFNSGTKEKGGRRDLQIRVSARPYHLLQGPKPDLVIGFNSGFGLKDTWLSSLPRLQSLRVPAFFTESSEYGCVMDDQTMAVATGGGTSSPQPNPFRSPFRLRAADNCMPWYCNAFIFHLVYKPPQGGTVRSAPGPAPRPPTPAAPPVPARRRRGEKKAARGPRRRR
The following text describes a protein:
Function:
Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. Associates with sites of DNA damage and modulates the MEC1 signaling pathway and the activation of RAD53 in response to DNA damage at phase G1. The complex also physically regulates DNA polymerase zeta-dependent mutagenesis by controlling the access of polymerase zeta to damaged DNA. Contrary to its human counterpart, the 9-1-1 complex, the checkpoint clamp complex shows no detectable exonuclease activity.
Miscellaneous:
MISCELLANEOUS: Present with 189 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MRINSELANKFSASTVHLEHITTALSCLTPFGSKDDVLIFIDADGLSFVRENNHVIKIQLLLSRELFMSYSYRNETEDHMKLCVKINHILDSVSVMNRNSDDIVECTLSYDGHGSPFVLIFEDSFISERVEYSTYLIKDFDTNGLELDRERISFEAIIKGEALHSALKDLKEIGCKECYVYAKTEANDENVFALISKSQLGFSKIKLPSNRSILEKLQVFDGDSTTVIDGFAVIGFFDFTSFDKIRKSTKIASKVLFRMDVHGVLSVNILSQTDDVIITDTTRPSNNRPGSIRQLQLPKDYPGIVIEVCMLEKESIDEAAQTEIELLMETNELGNRNSFKKSTIRKRYGTDKGNETSNDNLLQLNGKKIKLPSEEENNKNRESEDEENHCKYPTKDIPIFF
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MPTHKRRAYRRGPSLLAPAEDTKQENVQEHSFQTLDIDETLKHNLAQSGFKTMTPIQRYTIPLFTGESVAVFGLSRTGSGKTLAFLIPLLQRLISLQWQRLDGLGALILLPTAELCVQTFTVLNVLGRKYKMSVGLITGGHDVKEEQRVLMSMNVIIATPGRLLHQLSSCIQFSADNLRVLIFDEVDNLLEKGFYADIFSIIKYIPQQSEQLWLGFFTAIETPLVRKAIIKLIKYFGIAEHMLKIADMNTGVVTVANLDQLVQQETDDLKEKPKGKDLYKADGISLAQLAGISQKDITSDTYGENIQFVTSSCPDTGGIKLPPNLTNIIMTVHPADKIDILFSFLKSKSNSKIVIFVATARQAAFLCESFKLCEPGIPIMCLSGRMKAGKRHDTFIEFSGMRTAALITTDMCARGVDLPIVHWVVHFDCPDGVITYAHRAGRAARMNLPGFSLLFLTDQEQGFTKRLDEAKIDYQKKTVKLRTVVSIRQKLTELCITDTYIKHLAQKAIVSYAKSIHVQGDREVFPPASELNLTDIALSYGLASNINLSVGKQPGISTQHPASEQQMASATGIRQPEGEHTDADDEEERDDLLKVTKIVTSVLSSKEKEELQQEREKQIERKLLKGSIEEAARIAREAGRHKILNTSSDEESQSTSGAFSAKHTNNSAQDESDESELSSYTSASEEHSGTTFPNEASHVSRLQQRIAHNDSFDREAHKRKNRRKSKRRAASEQESSYDDSSFDESEEEMQSKRKQKP
The following text describes a protein:
Function:
Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool (By similarity).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSAAKQCFRNLWRASNSVFEGDPMILAAARDKIRTGFHNHRCCSPEEAKKEIQNGNAVAEILRRNVVQAEKQSNDTYSLKIRKTTEINTNRQFTEKKFPR
The following text describes a protein:
Function:
Stimulates microhomologous recombination. Enhances the recA-dependent precise excision of an IS1 element inserted within the E.coli galT gene.
Sequence:
MKTIEQKIEQCRKWQKAARERAIARQREKLADPVWRESQYQKMRDTLDRRIAKQKERPPASKTRKSAVKIKSRGLKGRTPTAEERRIANALGALPCIACYMHGVISNEVSLHHIAGRTAPGCHKKQLPLCRWHHQHAAPAEVREKYPWLVPVHADGVVGGKKEFTLLNKSEMELLADAYEMANIMH