lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Serine/threonine-protein kinase. Regulates organ size in coordination with MOB1A by modulating cell proliferation and cell expansion, possibly by facilitating cell cycle exit. Positive regulator of the pathogen-associated molecular pattern (PAMP, e.g. flg22)-triggered immunity (PTI) signaling by stabilizing BIK1 and activating RBOHD by phosphorylation to promote the extracellular reactive oxygen species (ROS) burst involved in defense responses to bacterial infection.
Subcellular Localization:
Cell membrane. Nucleus. Golgi apparatus, trans-Golgi network. Early endosome. Note=Observed at the plasma membrane and in the nucleus when associated with MOB1A.
Sequence:
MDHNSPKSRRSRKPEPKPDIYSTFVVHSDSDSDQGRDRDKRKAKPEEDENVDLYATMVYKGDSDGEGEEDDDDDSMLPPLLKRLPKDFGGGASLDYDDDDGDESGDFGTMIVKTDRSSHSKKNSPYSSKPRMGVSPRRRARGGDEESSDEEDEEEDDDDDDGDYGTFVVKSKDKKGKKKDKEIDMTTMGRAVASMQKSNFGGKTRKLDPSSSSSKLHGEDNRKMQQQNSKMSTTSLPDSITREDPTTKYEFLNELGKGSYGSVYKARDLKTSEIVAVKVISLTEGEEGYEEIRGEIEMLQQCNHPNVVRYLGSYQGEDYLWIVMEYCGGGSVADLMNVTEEALEEYQIAYICREALKGLAYLHSIYKVHRDIKGGNILLTEQGEVKLGDFGVAAQLTRTMSKRNTFIGTPHWMAPEVIQENRYDGKVDVWALGVSAIEMAEGLPPRSSVHPMRVLFMISIEPAPMLEDKEKWSLVFHDFVAKCLTKEPRLRPTAAEMLKHKFVERCKTGASAMSPKIEKSRQIRATMALQAQSVVAPSLEDTSTLGPKSSEELGITVPSKPPQNSTEAPLTSTLNRQHITGNTVLAGEGGDFGTMIVHGEDETEESDSRSQLVREKESSSSQFEGVPREFPGEELPDSWIHDKKKPPAIDLPVEASISQSMQASSSHEHRTKLHNIAGTQMEGGSDASGSTLKNETVGRKAFALQDKLWSIYAAGNTVPIPFLRATDISPIALLSENMIGGMQQDGNGTVAVEALQELFTSSDPQSKKGRRGQNEMPLPPSVYQRLTTSSSLMNLAQVLAYHRACYEEMPLQELQATQEQQTIQNLCDTLRTILRL
The following text describes a protein:
Function:
Efflux pump; part of the gene cluster that mediates the biosynthesis of viridicatumtoxin, a tetracycline-like fungal meroterpenoid with a unique, fused spirobicyclic ring system.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSKLSDNHSSASEGEKEAGDLESGPTAISSEPSFDDADRDPNLITWDGPKDPENPKNWPKGLRWKNTWTVSLFVFISPVSSSMIAPAMSDLAKSLGMHAEIEIYLSLSIFILAYSIGPIFFGPASELYGRVRLLQISNVWYLAWNLGCGFATTKGQLFAFRFLAGIGGSAPLAIGGGAISDMWTAEERGKAMGVYTLGPLLGPVVGPIAGGFIAEYSTWRWVFWSTSAAALAVQVVGFFWLQECHPGTLLRKRRDRLAKETGNENLHTAEKVETLGYKLLHAFERPVKMFTTQPIVFCMAIYMAYLFGISYLMFATFPEIWTVVYHESPGIGGLNYLSIAIGSFIGLFFNLKLVDRIYRSLKARNNGVGKPEYRMPSLAVGSVISTIGLFWYGWSIGNTHWIMPNIGALIFAMGTISCLQGMQTYIVDSYQTYAASAMAACAVLRSLCGFGFPLFAPYMYNSLGYGWGTSLLAFITMVVGWGAPFAFWHFGPRLRAMSKYASG
The following text describes a protein:
Function:
Probably functions as a manganese efflux pump.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTFEQLIPLIIMAFALGMDAFSVSLGMGMMPLKLRQILYIGMTIGIFHIIMPFIGMVLGRFLSEKYGDIAHFAGAILLIGLGFYIVYSTILQNEETRTAPIGISLFVFAFGVSIDSFSVGLSLGIYGAQTIITILLFGFVSMLLAWIGLLIGRHAKDMLGTYGEIVGGIILVGFGLYILFPI
The following text describes a protein:
Function:
Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit (By similarity).
Sequence:
MSDLQKSFAKSKLAKLPPEPPPIPESVADEDDDSGSSTETVTPSPVKQLFARPGGTRGFFDQELYLQRRVNDLDIVHHVYLTSPTNSGPLFVMHHGAGSSGLSFANCAAEIRKILPNAGILSADARDHGSTSVKRASEDGEADPETARLDLSLDTLNQDLLFVIRETQAKMGWETLPDIVLVGHSLGGAVITDVAKKGELGGKLLAYAVLDVVEGSAMDALQSMETYLSTRPSRFPSLPSGIEWHTRSRTIRNRTSARVSVPSLLYHEDVPKDPSKPWVWRTNLAETKPFWEGWFVGLSRKFLEARGGKLLLLAGTDRLDKELMIGQMQGKYQLQVFPDAGHFIQEDQPARTAQILVDFYKRNDRSALVLPPKVADMQASAAMKKGAGAGVPLGKAEGGTTGSFKRS
The following text describes a protein:
Function:
May be involved in the regulation of the inflammatory network. Its role as pro- or anti-inflammatory seems to be context dependent. Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 hours post-injection (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MLPLLLGLLGPAACWALGPTPGPGSSELRSAFSAARTTPLEGTSEMAVTFDKVYVNIGGDFDVATGQFRCRVPGAYFFSFTAGKAPHKSLSVMLVRNRDEVQALAFDEQRRPGARRAASQSAMLQLDYGDTVWLRLHGAPQYALGAPGATFSGYLVYADADADAPARGPPAPPEPRSAFSAARTRSLVGSDAGPGPRHQPLAFDTEFVNIGGDFDAAAGVFRCRLPGAYFFSFTLGKLPRKTLSVKLMKNRDEVQAMIYDDGASRRREMQSQSVMLALRRGDAVWLLSHDHDGYGAYSNHGKYITFSGFLVYPDLAPAAPPGLGASELL
The following text describes a protein:
Function:
Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
Sequence:
MANSKYEYVKDFEVNDNILPHTWIVIRIDGRAFTKFSQAHQFQKPNDLQALLLMNASAVAVVEDLADVVFAYGVSDEYSFVLRKTSTLYQRRARCVSIRVFQFHVSVLLCSLLTSVKHLTGFGLSSCNLLISKLISVICSLFASSYVMNWGKYFPETKLQYAPAFDGRAVCYPSESILRDYLSWRQVDCHINNQYNTCFWNLVGSGKSTAESQNMLKGTTADVKNNLLFDTFKINYNDLPQIFRKGSIVYRKKVEKVVKVEDGQEIKRLRSCAVVEHEDIIRDNFWTQYPYILGGK
The following text describes a protein:
Function:
Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MDCARLWLGLLMPAVAALDFSYHHQPEMEAFLKNVAQNYSSITHLHSIGKSVQGRNLWVLVVGRSPKEHRIGIPEFKYVANMHGDEAVGRELLLHLIEYLVTRDGRDPEITNLINSTRIHIMPSMNPDGFETVVKPDCFYNDGRDNSNLYDLNRNFPDAFELNEVPRQPETVAVMKWLTTETFVLSANLHGGALVASYPFDNGVPATGTLYSRSLTPDDDVFQYLANTYASRNPDMKRNSCRIKTGFSNGIINGYSWYPLKGGMQDYNYIWAQCFEITLELSCCKYPRKEKLPGFWKDNKDSLIEYIKQVHIGVKGQVFDQNQTPLSNVTVEVQDRKHICPYRTNKFGEYYLLLLPGSYVIEVTVPGHDPHLTKVTIPPKSQNFSALKKDILLPFRGQLNHISESNPLCPRIPLYSELQGHSAATKPSLFLFLVTLFHILFK
The following text describes a protein:
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Sequence:
MISSCQSFFRSSKVIYSFAVANQTRYSSPQLQYFQSLRIHKEKSIPSILNNLLINQMLQFDWVVDQGPKLVDILYSICGTRITNFLINNTIGKVFTAGENLESVERYLSQSDSNISYIMDYCSEALEGLEDQEKFYDENSSIFRQTILECAKNPEKKNMIAIKVSSLIDLNLLKKINQARLNIFEMFCKISQGKQTITIQQVFQYLKKEGINLNENEQKQFIIGVLKYSQNEMEIDEITWRYRVQPLFMFETDLNNNPAIKYFNNLNQEDIVLFEQFIERVKYFMDPALKNKVCVMVDAEQTYLQWAIDCFSEQMEAFYNQNYTLVYNTFQNYLKQTKQRMDYEIEKAEKFKLNIGIKMVRGAYMVEESKLAKQQNKENPINDGYQGTTTMIERNLEMLIKNIHKSPTKVFVASHNEQTIDFVKEIMNRYSIPNQGDVLFAQLYGLSDHVTYQLANEGYKIYKYVPFGKSEIMIPYLLRRAQETKKVLQSSSLQTLLLIDELKYRLYFK
The following text describes a protein:
Function:
Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MSSLVELSMAQEEDEHSLERKFSAAVKVVESLPVEGSFQPSDDMMLMFYSYYKQATAGPCDSPRPIGFWDSSSKAKWDAWSSLGNMTKEEAMKNYIEAIQLILETIPISDEVSELVQKLGNFYSEVDGEEVEENAVVSRPFTRPFADHKGFGDLWDDIQNVQEKDTDSVVPSVNNEEAEGSKESSHVEQDSDWRIEDDGDEDFSMSKEEEIIVSPDWSPDPRLLMVDNKGWRSGTKGSSSSVAPSLSSVTNGTHSSLNSEVEEEELICFIEPCAHYDPYMQFNGCLTSHIGAASDRNHRSTDSDNEEFCDSMEHLAMEERLSSSRGQSPGSGAATVKPNDLWFESNTTLKGAEEEVLILFSPSKHSNSLSRREKALLSPMSLCKSRDAACCRELHPVRASRENFNEQIAVALLRLQRDMASALHRLHTLEELARSQSRSPSPRLKDFQLVTRNILFLRPSWWPFDISPLAAFLTVFWPLVSHWLIKLYFQRRRRQVELSESDFIYILLSSVNAFSFFAATEFSFSPHRKIS
The following text describes a protein:
Function:
Plays a complex role in regulating the basal catalytic activity of the alpha subunit.
Sequence:
MNIGIPYDKLHILPLNQKIEIAGISVTCLDANHCPGSILILFEPPNEESETDSEESDVSGSDGEDTSWISWFCNLRGNEFFCEVDDDYIQDDFNLCGLSSQVPYYDYALDLILDVESSHVPCQHGDWLSMVLLVSGPVVGLLFRLARSEDLLQLLLGSYLQAEADCTKAISLDKKSMKACFHTSTTREMLGYYKEAIDDFRYALVLEPTNKRAASDAERLRNLILKKS
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle. The DASH complex mediates bipolar kinetochore-microtubule attachments and facilitates the formation of additional interactions between outer kinetochore components and spindle microtubules. During chromosome movement along the microtubule, it is required both for the sliding of kinetochores along the lateral side of the microtubule and also for microtubule end-on pulling on the kinetochore. Modulates cytoplasmic microtubule dynamics by tracking the plus-end of shortening microtubules and slowing their depolymerization.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton. Note=Associates with the mitotic spindle and the kinetochore. Kinetochore association occurs only during mitosis. In the cytoskeleton, localizes to cortical microtubules (Probable).
Sequence:
MSDLLNYLQSIAATSEKLLEPENPNAARFTDAVLHTHAITDLIRDTQKEELIAAEFKSLPKDWSERLASENPADYVACIEELLDIYPMQGGREYLETLVEKYNLHMSGIENLENVLLEQKEQLQQLEKRQTDQVSARENILQRETSEIQRLEREIEKVKQLIQS
The following text describes a protein:
Function:
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MMQGTCKISSIEKGALKNLYVVKMDCDNDLKIEFDITKELSIFSKDEEVTFIISREKPEYSEKDFCAHGYLFLERQQEDGSFIDEISLYGLIVKILSKNGLINSKLFKMMDHVYYCVKKKA
The following text describes a protein:
Function:
Required for the efficient removal of larval cuticles during the molting cycle as well as the synthesis of new cuticles.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Secreted. Note=Secreted from the hypodermis during molting.
Sequence:
MRNLNLILFTALAAVTYANVQPHDISQNGAVKDGNHLRIDLNETSSVELMDKWLSQAFSGLMAAVASKKIAKMPAEHQNIVQQCSKDAKDVREHAKCLVKLLDAEKSGKLGRKQYQKVVKSPETIVLPENPKMLTKKDLEKAENAGAAENNENLEWIGSFGTARAKRSYKVVHRDSYALRSTDDVDGMTKLAKSLTNTVRAMKNKTERAEPWVEAVGRIKKLGEEAKREKKNREVMKKRLKQMIDNTPAEFVDPRKPVALKQAEMEDENNEIAKLMRKKEADEIRVPLKFLRKAVKTALMLGGQNVTDFDQKTLKMVSPRMMSIVPEQEDESLFNLLSPSLFSLHDEGEGIEKLTSLPHLLKKLDNHGQNAWMDFIVEAAGVSDEVTKTEKVFREKKEKELRGTDGVPLYFTKENATKILGNEEKSKIEVFEDLDKSYSEEQKKKLNDDGFAFLTEKQMERLYGKESPYKHTKALKKFKRLRDDPEKYIEKDIRALAEAEKFRVARRADIVSSPFILTPLTFASAPLSNTFIVLSPLVLSPITLSPAVLGPIILSPWVFVPLILSPRVLSPLIVNPLVFSPIILSPLVLHPLILVPGVFNPIILSPLVLSPLILSPQVFTPLILSPFALNPLILTPMVGSPLILSPFVLSPIILSPQALFAVVLSPYALSPLVESKLIAAEVVLSPSWLS
The following text describes a protein:
Function:
Demethylates proteins that have been reversibly carboxymethylated.
Sequence:
MGHPLLLKTANLDPVPEDRPGTEAPPAPASAAITFSTSYTECYDSRLFVEANGQKVNVYTKGVFDDVPLIFFVHGAGFSGLSFGPLVKRVHTEGFCAALDLRGHGLTVNEDGTTALGDSMTIENFVADCKAVLDHLFTHMYKPANENAQKKSILLCGHSLGGSIVARLAVELQESYDIQLCCLIDINETVAIGAIPNMMSVLRKKPLAFSSEEALVSWLLSSHTLYSRSSALFQAPGLIHGSQHPNSGRVIADLINSDDNWRDWFIGLNDNFLGKYPGYKLLFIGGMEKLDKETEIAHMQGKLSIEVVPNSGHNLHEDDPNTVAFYFIKYLRRMHLSKKLIHKPFDFKKKDPDEDPIPLEEIKRLYGSGQ
The following text describes a protein:
Function:
Plays an important role in assembly of the mitochondrial large ribosomal subunit. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. May play a role in mitochondrial apoptosis.
Subcellular Localization:
Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids.
Sequence:
MNNKADSFFWNLRQFSTLVPTSRTMRLYRLGLCKPKIVHSNWNILSNFHNRMRSTDIIRYLFQDAFIFKSDVGFQTKGISTLTARRIERLLYARRLFFDSKQSLVPVDKSDDGLKKVNLNHEVSNEDVLTKETKPNRISSRKLSQECNSLSDVLDAFSKAPTFPSSNYFTAMWTIAKRLSDGQKRFEKRLMFSHPAFNQLCEHMMREAKIMQYKYLLFSLYSMVKLGIPQNTILVQTLLRVTQERINECDETCLSVLSAVLEAMEPCKNVHVLQMGFRILVDQQVWKIEDVFTLQVVMKCIGKDAPIALKRKLEMKALRELDRFSVLNSQHMFEVLAAMNHRSLTLLDECSKVVLDNIHGCPLRIMINILQSCKDLQYHNLDLFKGLADYVAATFDIWKFRKVLFILILFENLGFRPVGLMDLFMKRIVEDPESLNMKNILPTLHTYSSLNHVYKCQNKEQFLEVMASALTGYLHTISSENLLHAVYSFCLMNYFPLAPFNQLLQKDVISELLTSDDMKNVYKLHMLDTCLKLDDTVYLKDIALSLPQLPRELPPSHPNAKVAEVLSSLLGGEGHFSKDVHLPHNYHIDFEIRMDTNRNQVLPLSDVDTTSATDIQRVAVLCVSRSAYCLGSSHPRGFLAMKMRHLNAMGFRVILVNNWEMDKLEMEDAVTFLKTKIYSVEALPVAAVNVQST
The following text describes a protein:
Function:
Plays a role in chromatin remodeling and regulation of transcription. Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated.
Subcellular Localization:
Nucleus.
Domain:
The Bromo domain mediates interaction with histones that have acetylated lysine residues at specific positions. Also recognizes and binds histones that are butyrylated.
Sequence:
MGKKHKKHKSEWRSYDAGELGSPGDQSQYYVDKPLEKPLKLVLKVGGSEVTELSGSGHDSSFYEDRSDHERERHKEKKKKKKKKSEKEKDKYLDEDERRRRKEEKKRKREKEQCDSEGETEVFESVRKVDIEATDRPVRACRTHPAENESTPLQQLLEYFLRQLQRKDPNGFFAFPVTDQIAPGYFMIIKNPMDFSTMKEKISQNEYKSVTEFKADFKLMCDNAMTYNRPETVYYKLAKKLLHTGFKMMSKQAALLGDEDTTTEEPTPEIIMPTAAEVVKKSKKPSKDMFRVMEEDQSSIFEPEGNACSLTDSTAEEHVLALVEHAADEARDKINRYLPNCRIGYLKKNADGTLIYTVVNGDPENEEEDTHLVDLSSLSSKLLPSFTTLGFKEDRRHKVTFLNSTGTALSLQNNTLFTNLKPDQIDLMYAGYGDDTGIQCALSLQEFVKDCGSFAKRMVNDLLDQITGGDHSRTIYQMAGSEREGSSNSVLDYMALKTYSDVSLDMSMLSSLDKVKKELEHEDSHLNLDDASKLLPDFHDVHNDRGGSRPSSSSSVSNNSERDHHLGSPSRISVGEQQDIHDPYEFLQSPETENQN
The following text describes a protein:
Function:
Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MLSSLLAVPLAILALRPSLVAAQGDLSGANNVTDLEGTWSSNSAVSTGGDICIPAEMKFNYPNNSGISYSFTNDGFFEEVQYQYNANASNPACIQAYIYWQHGTYSLNDNGSMTLFPFTSDGRIQVQDPCAATTNIITYYSNQVLFTDWGIVVDSSSGRYTLNLNKYDGSKMARMFLVAKPPNMLPTQILTGVNASGQTSTRKRSFTQSLDFLKRSSAEPRWSGLLFAQGYPTSFTMLGLAGLAVVGVLALV
The following text describes a protein:
Function:
Part of the processive rRNA transcription and antitermination complex (rrnTAC). The complex forms an RNA-chaperone ring around the RNA exit tunnel of RNA polymerase (RNAP). It supports rapid transcription and antitermination of rRNA operons, cotranscriptional rRNA folding, and annealing of distal rRNA regions to allow correct ribosome biogenesis. This subunit may play a central role in organizing the structure.
Subcellular Localization:
Cytoplasm.
Sequence:
MNPMLNIAIRAARKAGNVIAKNYERRDAIESTQKGINDYVTNVDKASEAEIIEVIRKSYPDHTIITEETGAIEGKDSDVQWIIDPLDGTRNFMTGLPHFSVSIAVRVKNRTEVGVVYDPIRNELFTAVRGEGAKLNEVRLRVDSKREIQGSILATGFPFKQPKLMPAQFAMMNALIEDAADFRRTGSAALDLCYVASNRIDGYFEMGLKAWDCAAGDLIVREAGGLVCDFDAGNSYLRSGNIIAAPSRVIKEMLNKIRPCLGAEFNH
The following text describes a protein:
Function:
Removes the 1-phosphate group from tetra- and probably hexaacylated lipid A species. Absence of the 1-phosphate group renders the bacteria partially resistant to host-derived cationic antimicrobial peptides (CAMP), allowing it to camouflage itself from the host innate immune response, and plays a role in the long-term colonization of the host's stomach.
Miscellaneous:
MISCELLANEOUS: In this organism most lipid A is tetraacylated without a phosphate group at the 4'-position and a phosphoethanolamine residue at the 1-position.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKKFLFKQKFCESLPKSFSKTLLALSLGLILLGVFIPFPKVPKHQSVPLALHFTEHYARFIPTILSVAIPLIQRDAVGLFQVANASIATTFLTHATKRALNHVTINDQRLGERPYGGNFNMPSGHSSMVGLAVAFLMRRYSVKKYLWLLPLIPLTMLARIYLDMHTIGAVLAGLGTGMLCVGLFTSPKNLN
The following text describes a protein:
Function:
NAD(P)H oxidoreductase involved in the ubiquinone biosynthetic pathway. Required for the O-methyltransferase activity of COQ3 (By similarity). Able to catalyze the oxidoreduction of 3-demethylubiquinone into 3-demethylubiquinol in vitro (By similarity). However, it is unclear if 3-demethylubiquinone constitutes a substrate in vivo (By similarity). May also play a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve.
Subcellular Localization:
Mitochondrion matrix. Mitochondrion outer membrane. Note=Mainly localizes to the mitochondrial matrix.
Sequence:
MLMCRRWLVCSLRCHYRSFSFSAARRTVMPAWVIDKYGKNDVLRFTKNAALPIIHYPNEVVVKVHAAGLNPIDISMRGGYGAATMAMKRDPLNISQSGGEFPLILGRDVSGEIMECGLDVKYFKPGDQVWAAIPPWKQGSLAEFVVVSGNEVSHKPKSLRHDEAASIPYVAATAWSAIVNTGGLNKDNSAKKRVLILGGSGGVGTFAIQMVKAWGAHVTVTCSQNAERLVRDLGADDVVDYTAGPVEKQLKNLEKFDLILDSIGGETEKWALDLLKPWSGAKFVTLITPFLQNTDRLGLADGMMQSAVTVGCKVVKNLRKGVHYRWGFFAPSGSALDEVSEMVDAGKVRPVVEEVFSFAQVPEAFQKVEQGHARGKTVVSIMEDQKE
The following text describes a protein:
Function:
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
Subcellular Localization:
Plastid, chloroplast. Mitochondrion.
Sequence:
MSSHHQILQIRSDPFVLSHCCRHTRLTSSLTLQSPLKQPFSCLPFRWRRSYRGGVRSSTTETHGSKKEALVSETATTSIELKRVYPFHEIEPKWQRYWEDNRIFRTPDDVDTSKPKFYVLDMFPYPSGAGLHVGHPLGYTATDILARLRRMQGYNVLHPMGWDAFGLPAEQYAIETGTHPKTTTLKNIDRFRLQLKSLGFSYDWDRELSTTEPDYYKWTQWIFLQLYKKGLAYQAEVPVNWCPALGTVLANEEVVDGVSERGGHPVIRKPMRQWMLKITAYADRLLEDLDELEWPESIKEMQRNWIGRSEGAELNFSILDGEGRETDKEITVYTTRPDTLFGATYMVVAPEHQLLSYFVTAEQKQQVEEYKDFASRKSDLERTELQKDKTGVFTGCYAKNPANGDAIPIWVADYVLASYGTGAIMAVPAHDTRDNEFALKYNIPIKWVVRNEANSSDDAKQVYPGLGIIENSSTLETGLDINQLSSKEAALKVIEWAERTGNGKKKVNYKLRDWLFARQRYWGEPIPILILDESGETIAISESELPLTLPELNDFTPTGTGEPPLSKAVSWVNTVDPSTGKPAKRETSTMPQWAGSCWYYLRFMDPKNPEALVDKEKEKYWSPVDVYVGGAEHAVLHLLYSRFWHKVLYDIGVVSTKEPFKCVINQGIILGEVQYTAWKDQEGNYVSADTEERLNEHQQVTIPEEKVIKSGDHFVLKEDPSIRLIPRVYKMSKSRGNVVNPDDVVLEYGADSLRLYEMFMGPFRDSKTWNTSGIEGVHRFLARTWRLVIGLPQSDGSFKDGTLVTDDEPTLEQLRTLHKCIAKVTEEIESTRFNTGISGMMEFVNAAYKWNNQPRGIIEPFVLLLSPYAPHMAEELWSRLGHPNSLAYESFPKANPDYLKNTTIVLPVQINGKTRGTIEVEEGCSEDDAFVLASQDDKLRKYLDGQSIKKRIYVPGKILNVILDRTNVKVTTK
The following text describes a protein:
Function:
Probably plays an important role in neuronal membrane skeleton.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Sequence:
MTTDISVSVRWDPATQQEVIDDYDYDGGNSSSRLFERSRIKALADERESVQKKTFQKWVNSHLVRVGNRIGDLYTDLRDGKMLLKLLEVLSGERLPRPTKGKMRIHCLENVDKALQFLRDQRVHLENMGSHDIVDGSSRLTLGLIWTIILRFQIQDITIEETDNNETRSAKDALLLWCQMKTAGYQNVNIRNFTTSWRDGLAFNAIIHKHCPELVQYDKLSKSNAMFNLNNAFNVAEQKLGLTKLLDAEDIYVDQPDEKSIITYVVTYYHYFSKLKQETVQGKRIGKVVGLAMENDRMITEYETLTSDLLRWIESTIQSLSERDFANSLAGVQQQLLQFNNYRTLEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYFPKEGKMISDINKAWERLEKSEHERELTLREELIRQEKLEQLAARFDRKAGMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAIETDILAYEERVQAVVAVAQELEAENYHDIDRINARKDNVLRLWQYLLELLRARRMRLELSLQLQQNFQEMLYILDSMEELKVRLLSEDYGKHLMGVEDLLQKHALVEADINVLGERVKMVVQHSQRFLETEATGGFGPCDPAIIVDRVQQLEDAYAELVKLAVERRARLEESRKLWQFYWDMADEENWIKEKEHILSTGDIGHDLTTIHLLISKHKALEEDIASHEPALYSVVNVGEELIQQEHFGSEKIQERITEMVEMWNHLCETAAYRRKRLEEAVSYHQFFTDADDVDTWMLDVLRLVSSEDVGRDEANVQSLLKKHKDVTEELKNYASTIDALKEQSEQLGEQDRTSPEVVERLASIERRYRELMELAKLRKQRLLDALSLYKLFSEADGVEQWIGEKERMLETMVPAKDIEDVEVMRHRYDGFDREMNANASRVAVVNQLARQLLHVEHPNSEDIVARQNQLNARWAELRDRAEAKRDELQSAHGVQTFHIECRETILWIEDKIRILQSTDSLEMDLTGIMTLQRRLSGMERDLAAIQAKLDSLDKEAEKIGVEHPEEDEVIHERLGQIRSVWENLTQMLKERDAKLEEAGDLHRFLRDLDHFQAWLTKTQTDVASEDIPASLAEAEKLLSQHQGIREEIDNYTDDYSRMMDYGERITAEETTSDDPQYMFLRERLKALRDGWEELHQMWENRQQLLSQSLNLQMFLRDAKQAEVLLAHQEHVLSKDEMPANLEQAENAIKRHEAFLTTMDANDDKVNNVIQFAQRLEDEGHFAADKAQRKAENISERREANRQRAVQLMEKLRDALQLQQFLQDCEELSEWIQEKNIIAQDETYRSAKTVHSKWTRHQAFEAEIASNKDRLYHIQQAGEQLITEKPEIISTIDPRIQELSHQFDDLERTTREKGERLFDANRQVLYEQTCDDIDTWMSDLEKQMVTGGTGEDLASVNILMQKQQMIETQMAIKAQQVSELGAQAEYLERMTPEKVEDIQQKKEAVERRFDELKAPLVRRQRDLEKKKEAYQFRRDVEDEKLWISDKMPLATASDNGNSLFNVNVLKKKNQSLRTEIDNHEQRIHLVCNNGQKLIDEDHADSEEFANLIEELLDTWQTLKDAMDNRRAKLLASERAQQYFFDASEAESWMSEQELYMMVEDRGKDEISAQNLMKKHQTLELAVEDYAETIRSLGETSTQLIAEGHPDSDQIAVRQAQVDKLYAGLRDLAQERRAKLEEALQLFMLSREVDDLRQWIADREVVAGSHELGQDYDHVTLLWERFKEFARDTETIGTERVAAVNEIADQLMGARHSDAATIAEWKDDLNEAWADLLELIDTRTQMLAASRELHKFFHDCKDVLGRIVEKQNTLSDELGRDAGSVSALQRKHQNFIQDLQTLQSQVQGVQEDSQRLQTAYAGDKAREITGREGEVVNAWLQLQALCEGRRQKLADTGDLFRFFSMVRTLVLWIEDLIRQMNTTEKPRDVSGVELLMNNHQSLKAEIDARGDNFSACIALGKELLSRGHYATNEIKEKLVALTNQRNSMLHRWEERWEHLQLILEVYQFARDAAVAEGWLMAQESYLMSHELGHTIDEVENLIKKHEAFEKSAAAQEERFAALERLTTLELREQEKLLGEDGEAYDQHFDGYNRPEDTYELKELKRRQEDDERQRAEELAAQQAALAALHSPPEGSHHDQTDGDTSPSEPISGSTDKDPTTEATEGRASPKAEQAIKPVPERRSSVAGGDDVYEGTVNRKHEWESTTKKASSRSWDKVYLTLRQGDLAVYKDQKTARGTPEAHYRNESPLDIRTAVAEVAADYTKKRHVFRLKLSNGGEYLFQAKDDEEMNGWVTKLQASTTAAVESASAGSSRAQTMPAQATKDEPKKRSFFTLKKK
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MAEQDVENDLLDYDEEEEPQAPQESTPAPPKKDIKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQIEPVNGQVTVLVMCHTRELAFQISK
The following text describes a protein:
Function:
[Vasoactive intestinal peptide]: VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles (By similarity). Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder (By similarity); PHM-27 is a bioactive form from proteolysis of the same precursor protein, that causes vasodilation. It is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.
Miscellaneous:
MISCELLANEOUS: X's at positions 28 to 44 were included by homology with the human precursor sequence.
Subcellular Localization:
Secreted.
Sequence:
HADGVFTSDFSRLLGQLSAKKYLESLIXXXXXXXXXXXXXXXXXHSDAVFTDNYTRLRKQMAVKKYLNSILN
The following text describes a protein:
Function:
May act as an E3 ubiquitin-protein ligase and a transcriptional repressor (By similarity). Involved in the regulation of embryonic and adult hematopoiesis. Required for normal development and survival of both committed erythroid progenitor cells and posterior mesenchymal cells.
Subcellular Localization:
Nucleus.
Sequence:
MEVEASGTEDNGDGGAKEPEAVVSIDTETKEAADEAKSQETVPQTPTTSSDSSSSGGGGEATDGTPNAESADPPPPPPPPPPPPPSTPADSTAAAASPAVLTEMSPPPPASTSSSSSTPAAPINLLDTCAVCKQSLQNRDCEPKLLPCLHSFCLKCIPQPDRKITMPVQGPHGQDTRIVNVMRCTVCHQDYKQIDMVDNYFVKDTSEATNTSVENSTQVCTSCEDNASAIGFCVECGEWLCKTCIEAHQRVKFTKDHKIRKKEEVSPESVGTSGQRPVFCPVHKQEALKLFCETCDTLTCRDCQLLEHKEHRYQFLDEACQNQKGIIATFMTKLQEKRGLVEYSASEVQKRLKEVAETHKKVEHEIKIAVFTLINEINKKGKSLLQQLESVTKDRSMKLLSQQRDISVLAQQIIHVLNFTNWAITNGSSTALLYSKRLITYQLRLIMKARVDAVPPANGAVRFFCDPTFWAKNVVNLGNLVIEKVAPTAPPSNMMVNQQISPGHNHPGKHSGQINLAQLRLQHMQQAAIAQKHQQQHQHHQQQQHQHQHQQQQQQQQQQQQQQQQQQQQQQHQQQIQQQMRIASQMSQHPRQGAPQMIQQPPPRLISMQALHRGGVNGSSHMFPPHHLRMVSAQNRMPSAQPRLNGQPYPMMQPQLQRQHSNPGHAGPFPVASLHNISAANPTSPTSASMANAHMHRGPSSPVITPIELIPSVTNPENLPCLPDIPPIQLEDAGSSTLDNILSRYISANAYPTVGPTNPSPGPSTHSPGSSGLSNSHTPARPSSTSSTGSRGSSGTTVDQVKVKQEPGVEEECSYSGANVKTERTKDGRRSACMMSSPEGSLTPPLPILGSVSTGSVQDILRTLGENVKSEPQSDNLSSCTNPNSRATLTNGTSGSNGGQRGGATNANSQTTAGKEDDPNEDWCAVCQNGGELLCCDHCPKVFHITCHIPTLKSSPSGDWMCTFCRNLANPEIEYNCDDDPPRNKEKNEMAMSPEEQRRCERLLLHVFCHELSTEFQEPVPTSVPNYYKIIKHPMDLTLVKRKLQRKHPLHYKSPKEFVSDVRLVFSNCAKYNEMSRIIQVYDEEKQSNVQADSEVAEAGKAVSLYFEERLLEIFPEQTFPVVMEKETQIEAEKEDSDDSDDDIIQPKRKRLKVDTEMLLHIK