lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site.
Sequence:
MKDPVLYGEFRRQLKAVQIAIRVHGASNNSFTDNCQGNPHQAPYSIEVRSDAISLVQDKPLKQWTFLLPEGLRALPGSCSGLEWIQGEGIQMRLQLETDDLNGAQEAEPEKGGELDEETGDLFLKALENPSCEVSCSRCGAPLVQPSGGFKKVLPLPSGDWGDMAADMWCCKSKVIAEERGKMSPLQLNPEEGSIMVDDLHLLINSRMLTKGSVQIEVKKMTGLSNTKQTGKSFNVLCQRCGNILGSIDNSGGSSQLETTKLYRYAVCIQHKRNHLSDKMNNPLQQTICSVMVSLFKNQMTFKYIIEDEEEHKPRLLIWLLGIDTRLLFGGAPSTIKDQAGSSSLHQPSPPIPPEGSRLEVQLKSLPIVKVLYQTCNSDTGQRLGQEWNKDLMVHGITLTMEACLQLGLLLATSTLQAPPSMRQMNGFRVGSLKL
The following text describes a protein:
Function:
Catalyzes the dehydration of D-mannonate. Has no detectable activity with a panel of 70 other acid sugars (in vitro).
Sequence:
MLKIIDAKVIVTCPGRNFVTLKITTEDGITGVGDATLNGRELSVVSFLQDHMVPSLIGRDAHQIEDIWQFFYRGSYWRGGPVAMTALAAVDMALWDIKGKVAGLPVYQLLGGACRTGVTVYGHANGETIEDTIAEAVKYKAMGYKAIRLQTGVPGLASTYGVSKDKMFYEPADNDLPTENIWSTAKYLNSVPKLFERAREVLGWDVHLLHDVHHRLTPIEAARLGKDLEPYRLFWLEDSVPAENQAGFRLIRQHTTTPLAVGEIFAHVWDAKQLIEEQLIDYLRATVLHAGGITNLKKIAAFADLHHVKTGCHGATDLSPVTMAAALHFDMSITNFGLQEYMRHTPETDAVFPHAYTFSDGMLHPGDKPGLGVDIDEDLAAKHPYKRAYLPVNRLEDGTMFNW
The following text describes a protein:
Function:
Transports natural purines (adenine and guanine) as well as purine analogs. Confers sensitivity to 8-azaadenine and 8-azaguanine (8-azg).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEQQQQQQLPSTTTRPKPKLLNRLNTYVGSSRVGKRFKLAERNSTFTTELRAGTATFLTMAYILAVNASILSDSGGTCSVSDCIPLCSNPAIEPSQCTGPGLRLIQPDVSCKFNPVNPGYAACVEEIRKDLIVATVAASLIGCVIMGLMANLPLALAPGMGTNAYFAYTVVGFHGSGSISYRTALAAVFIEGLIFLFISAIGFRAKLAKLVPKPVRISSSAGIGLFLAFIGLQNNQGIGLVGYSPSTLVTLAACPASSRISLAPVITSANGTVSLLAGGSVSGDIMCIHGRMESPTFWLGIVGFVIIAYCLVKNVKGAMIYGIVFVTAVSWFRNTEVTAFPNTSAGDAAHDYFKKIVDVHVIKHTAGALSFSGINKGHFWEALVTFLYVDILDTTGTLYSMARFAGFVDEKGDFAGQYFAFMSDASAIVIGSLLGTSPVTVFIESSTGIREGGRTGLTAITVAVYFLLAMFFTPLLASIPAWAVGPPLILVGVMMMKSVTEIDWEDMREAIPAFVTMILMPLTYSVAYGLIGGIGSYVVLHLWDWGEEGLVKLGFLKRKVKEEDNNNGVVKASEIDTTV
The following text describes a protein:
Function:
Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes.
Subcellular Localization:
Nucleus. Nucleus, nucleolus.
Sequence:
MVKAGELVEQQKAAMEEEANAEAAEDQEEPEDTACSSSSKKKKKVVPGIVYLGHVPPRFRPLHVRNLLSAYGEVGRVFFQAEDHFVKRKKKAAAAAGGKKGAKYSKDYTEGWVEFRDKRVAKRVAASLHNTPMGARKRSPFRYDLWNLKYLHRFTWSHLSEHLAFERQVRRQRLRAEVAQAKRETDFYLRNVEQGQHFLAADGDATRPNSSWTFTQRPTEQEFRARKAARPGGRERARLANVEDQARSNRGLLAKIFGAPLPAESKEKP
The following text describes a protein:
Function:
Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSPTTHWGDKFLNLRVPPAGVFVVAFFARVALIFYGIFQDRTLLVRYTDIDYQVFTDAARFVTEGRSPYLRATYRYTPLLAWLLTPNIYLNELFGKFLFISFDLFTAFLLYRLLLLKGLGRRQACGYCVFWLLNPLPMAVSSRGNADSIVASLVLMTLYLIEKRLVACAAVSYGFAVHLKMYPVTYILPIALHLLPERDSDEGLRQSRYSFQVRLYEFLKRLCHRAVLLFVAVAGLTFFALSFGFYYRYGWEFLEHAYLYHLTRRDIRHNFSPYFYMLYLTAESKWSFSLGIAAFLPQFILLSAVSFAYYRDLVFCCFLHTSIFVTFNKVCTSQYFLWYLCLLPLVMPLVRIPWRRAVVLLMLWFIGQALWLAPAYVLEFQGKNTFLFIWLAGLFFLLINCSILIQIISHYKEEPLTDRTKYD
The following text describes a protein:
Function:
Catalyzes the activation of medium/long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension. Also involved in the degradation of cholesterol via the degradation of the side chains of C-24 branched-chain sterols. Catalyzes the ATP-dependent CoA thioesterification of the sterol 3-oxocholest-4-en-26-oate to yield 3-oxocholest-4-en-26-oyl-CoA. It can also use 3beta-hydroxy-5-cholesten-26-oate.
Sequence:
MAVALNIADLAEHAIDAVPDRVAVICGDEQLTYAQLEDKANRLAHHLIDQGVQKDDKVGLYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELRYLFDNSDMVALVHERRYADRVANVLPDTPHVRTILVVEDGSDQDYRRYGGVEFYSAIAAGSPERDFGERSADAIYLLYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGEFVKDEYDLAKAAAANPPMIRYPIPPMIHGATQSATWMALFSGQTTVLAPEFNADEVWRTIHKHKVNLLFFTGDAMARPLVDALVKGNDYDLSSLFLLASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGTSVVAAGQAHGGGPRVRIDHRTVVLDDDGNEVKPGSGMRGVIAKKGNIPVGYYKDEKKTAETFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGEKVYPEEVEAALKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAELDSFVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAGHVTSGG
The following text describes a protein:
Function:
Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRRLVGGLASRGGSIMNLRASHFSLSSPSSPLHASQPSPCHTSVRAIGTAMPGAMHQPGESGQAAGSSTTIPGKETWGQFSAKMRHGRRRIRVIDIAAKMSYEYQMLKKMCKRRPAMRQWAVRDDYCDMSPGVVVMSPSMQAAFMKVFRLKDKGLIRQCLRDIIPIIEYRNREERPAAMRDKASDMIPEGEPDTLNQKKRELFERKETGENFKPLYLHDKRSQAKLRFKIRQRLIKFQRQIAIANAVASRTVLYSTDDAIGYFLFRGAAMYAGMHRVFFELSKQLPHFVPKSMLDFGAGTGTAILVAKEVYDPGALAYPLYRSMRQTMTGNVSAQAQQLRELRYDLRRLSRNNTEKRKARFMAVAALLERGEVDPADLPADLRREIAQVAANAAANKKRRLISESHARYREVVDGTEWEDGDPLGEKKSMAEDPSNVFDGEEDGDGGGDGAAAGERTWWEKLVDMENATAQERASRRLQPLQEVTAIEPSPGMMEIGTMVLHDDIPNVAWKRYLLPEDESIQHDLVVAAYSLSEVADSANRTRLVQQLWKMTRGVLVLVEFSNLHNFNLLMEARDTILEEKGIGLWDWQPTIVAPCPHEQRCPLRHCKAGVKSKRMRLCTTEAQYRATFIDVWARHMPLKVGIEPISYMIFARNELVPERAERREAQVKREEAERVQARDAKQRELYAASLSLKDVVFDRLSDEALHRPSTGVPEKLSGAAAADDVAPSSTLTQALPSGATSAAEVGQLPLTVPRLAQTSAQRYNKLVYPLQFPPATHRYNRAFVDAGYQRQRAITPSEMLVVREELKDMLRRVSRVSPSYLRVVRDPTCRGKIQACFCTPDGDLITARVYRRFYGDHSSVRRHTTMRWQHIGGWKLLKRIRSGSLFPHDLPLYAVNRHPQVDFPNTLVGVKHSTVEKTAMQYNDPMSLMETPEEELSREEVKQKRRLLRDEEEHRKAEAKLEEVLGTKIRDASLEGHIDARRRISAEEWAKAVRHARQKTVRHTQQTIPNAAKMRALKRTLEVRHRNVWREMKQNRRR
The following text describes a protein:
Function:
Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor VPS10. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS29-VPS26-VPS35 subcomplex may be involved in cargo selection.
Sequence:
MSIFFKPPIDIEILFDNEESRKHVDIATRSSNSSYKSMKESLPVYEDGESLGGIVTLRVRDSKKVDHLGIKVSVIGSIDMLKSHGSGNSSSKKVTSSTSSSSSNGSVDVRKNSVDQFLCQSYDLCPAGELQHSQSFPFLFRDLSKRYESYKGKNVDVAYYVKVTVMRKSTDISKIKRFWVYLYNSVTTAPNTLSANETKATTNDIAGGNYAADNASDNTQTKSTQGEAADVNQVLPISHSNNEPKPVRLDIGIENCLHIEFEYAKSQYSLKEVIVGRIYFLLTRLRIKHMELSLITRESSGLQTSNVMTDSTAIRYEIMDGSSVKGETIPIRLFLSGYDLTPNMSCNYFNVKNYLSLVIIDEDGRRYFKQSEITLYRTR
The following text describes a protein:
Function:
Probably part of an ABC transporter complex. Probably responsible for the translocation of the substrate across the membrane (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPAVFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPLADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHASMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPFFLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIGFVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLAGAPVFALILIRQHRGGRSL
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Subcellular Localization:
Nucleus.
Sequence:
MISDIFFPFLSFIIENFYFSFRKPTTTTTTTTRSKILHQTPKQMSEHNIPILINQYIAASSGNDEEAVSNYIFELSNLISNDELSLLQFIQHLGPSLTSDKDSIRSKSIECLSKTIISLSDSKLTKQDINVLIEFLLNKLIDNDQICLQYSLMGINSLICKKNFLGDTNIEKILQQLYKNYDPKKNLAKVRYETFQILLNLLNQFNQYLNSSSIQLSNLYIKTFIHIASGEKDPRNLLISFELNNKINANFQFDNKNNELHQQFITDLFDICFCYFPISFKPPSNDPYKITSEQLKLALRETIASQSKFAPEAFPSLIEKLTSTNPTIRNDTLKTIELCIKNYSKNDATVIEEYWMTIWNALKFEILHNDISSNFNPTNNTIVASDYDEIDDNDEFKPLVLTLVILNRLISTLSQPEIMLHTVVEELKPNLEVMKEKSIKSSLILSSLGSTSVDNLNYIVDFLFQYQIWGKFLNIDKKEENEEQQEFDTNEDVSLNIAKQRDLIDSIGFVLTAYQVLKPTAHCHLLDYKDYILIFLGQLLTITSNLEKTLKCKIIQQLIKLIKLPGYLNTNELELILGNYFKQFFLDTTKTSGKKDVILQEIINGLIEVSQDSQITSLTIEFIINPILNQLLTTEDNDGGDVNIETFQFQLEIVGDLCINYQILEVISIRLLNKLPIINNQSNNNLQLYKIIINLFIELIKKIESIQQFLTNSWYKNFIPKFMENLLIVLPLENILHNNDDNYELFEIVGDLLGLIIKFIDVSKHQEILDQLNQTFIINNNDDDDDDEETNHQGPFKYPSNLLIEPNNYINVYNKILSSIDKTCVFKQDVDQQVIESIINLIYKIGNDDEYLRLQYLQTLCLLINKFTNNADFIESKLKFLEKVEEQDFPITKKDFISFEIFIWILKGLIVKLDKLGINYLNQLLELFVITENYKLKQLIGKSLQILFIDLKIFTNERITTTDNTNSTNGGIKSSSQLISKVKNLQVKSLYKQHIFVIILPYLINDSNENFTNDADFNLKFNSLSLIIENLSINGNNNILINQLSEILPITLYSLIKIPIDANSNSNLLASLIILNIILKEEEK
The following text describes a protein:
Function:
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Subcellular Localization:
Mitochondrion.
Sequence:
MLSVRALAVTRSVRSGARGLSMARPLAAASALERDIAKIRNIGISAHIDSGKTTLTERVLFYTGRIKEMHEVRGKDEVGATMDSMELEREKGITIASAATYTTWKDHNINIIDTPGHVDFTIEVERALRVLDGAVLVLCSVGGVQSQTLTVDRQMKRYKVPCIGFVNKCDRPGANPARVTNQLRQKLRHNAAMVQLPIGLEDRMEGVVDLITNEAVYFQGQQGMQVVRTEIPANMSEEVAAKREELIGHLADVNEEIADLFLMGEEPSPEQLKQAIRDAVLARSFTPVFVGTALKNLGVQTLLDGVLEYLPAPNEVESYALDTNDAEKKVPINMGNSEAPFLGLAFKLEQGQFGQLTYLRTYQGVLRKGDFIYNARTDKKVKVPRLVRMHSASMEDVNEVHAGEICAMFGLDCSSGDTFTDGSTSLTMESMFVPNPVISLSIKPKNSTDLASFSKALNRFQRQDPTFRVHLDPESKETISAAWVNFILSWIVQTCNSWFACRMTPQIYKEIMEREYNCPTITGKPKVAFRETMTAPMKFDYIHKKQSGGAGQYGRVQGEIVPLDGDEAADVIFEDETVGQNIPKNFIPAIEKGFREACEKGPLTGSPIQGIKFILKDGNAHAVDSNDMAFTMAGIGAVRQAFQKGSPVVLQPIMQVEIVVPDEFQGTVIGGINKRRGTIMDSETSEGSTVIKAEVPLNDMFGYSSELRAQTQGKGEFAMEYTRHELVLPQVQKELMEEYEKSLKQ
The following text describes a protein:
Function:
Required for DNA transformation jointly with TfoY (tfoX2).
Sequence:
MTGTGDVNLKIKEIEMSHLEERFFNFVKKLGRFNKRSMFGGVGLFNEDAMFSLVTDGRLYVRGGGEVDARFEELGCERFKHVKKTTIATVNYFDVTELFEKKPASLLSIVQEAMENSRLEREFKKSKENRRLRDLPNMQLTLERMVKKAGVPDVDSFLEIGAVDVFKKVNHTYGGDVDVKLLWKFAGAESGVHWTLLQEPAKQALLQQV
The following text describes a protein:
Function:
Plays a role in 2-micron plasmid partitioning. Antagonizes transcriptional repression of recombinase FLP by REP1-REP2. Regulates both stability and copy number of the plasmid by blocking the formation of the REP1-REP2 repressor complex.
Sequence:
MPYKTAIDCIEELATQCFLSKLTDDDVSTFRRVCSKENDIIKLALRIPRTIDYTSILRLLYDTLPLRSLSFNEALPLFCYSIDPAQQRQCDLRFYLRDVVKLARPRKRLEMQKALLQWLPSLLSDVTLQLLNDIRIRFEEIQPNIRQTVLQIYDRTCYPSLNFEHPNLGVFPETDSIFEPV
The following text describes a protein:
Function:
Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQPFGVLDRYIGKTIFTTIMMTLFMLVSLSGIIKFVDQLKKAGQGNYDALGAGMYTLLSVPKDIQIFFPMAALLGALLGLGMLAQRSELVVMQASGFTRMQVALSVMKTAIPLVLLTMAIGEWVAPQGEQMARNYRAQAMYGGSLLSTQQGLWAKDGNNFVYIERVKGDEELAGISIYAFNDQRRLQSVRYAASAKFDPEHKVWRLSQVDESDLQNPKQITGSQTVSGTWKTNLTPDKLGVVALDPDALSISGLHNYVKYLKSSGQDAGRYQLNMWSKIFQPLSVAVMMLMALSFIFGPLRSVPMGVRVVTGISFGFVFYVLDQIFGPLTLVYGIPPIVGALLPSASFFLISLWLMLRKS
The following text describes a protein:
Function:
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
Subcellular Localization:
Cytoplasm.
Sequence:
MRIILASSSPRRRQLMELLGIEFEVEKPDVEEEFLESPEETVRELSLRKAEWVFKKRKEEEILVIGSDTVVVLDGNILGKPESLEEAKGMLKKLSGKWHVVYTGVAFVSSETKDVIVSSTKVRFRELPESVIDYYVEKYRPLDKAGAYGIQDFAAVFVEKIEGDFFTVVGFPLGMVWQYLYEKGWWKVASKREDDKGGARVAFG
The following text describes a protein:
Function:
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus.
Sequence:
MEEPKGLSFVEQFVKEKVPDLSEKKLEKQLVNLYQKPILLLCEKSGKVKKKKQKKSLRQCKADLKRALTQNSNYAEYEPLRKMWSEYIREVLYVGGKKQVDMKMAQEVFLKADLHGAVISVVLSNCKHLEKTKGTIITESKNMFQIVTLKNTIRNIPKKNSVFEIIFENLRVTIFGDQFCIKPSQRLTKKFKNYIPV
The following text describes a protein:
Function:
Required for corrinoid utilization. Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import. Probably responsible for energy coupling to the transport system.
Sequence:
MKLSLDGVTLSYASVTVLHGISMEFCEPGVVGIIGPNGAGKSTLLRCINNVLTPKSGRICLDEQKTYDMDAAEIARNFGYVPQEFPITFQATVFDTVLMGRRPFSSWRVSRNDVEIAAGAVKMLNLEQVALRYHSELSGGQQQRVMIARALAQNSRVLLLDEPTSKLDIRHQLEVMDIIRALVDKRGLLSILVIHDLNLASRYADKLIMLKDGKIYAAGDPVSVLTQKNIRAVYGVEAAVVLEDNLPHIIPKRPV
The following text describes a protein:
Function:
Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3. According to another report, the stabilization is independent of the proteasome (By similarity).
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes primarily to the nucleus in interphase, concentrates at kinetochores prior to nuclear envelope breakdown and during early prometaphase, and disappears from kinetochores upon microtubule-binding.
Domain:
Mainly composed of disordered low-complexity regions outside of the C2H2-type zinc fingers. Coacervation depends on hydrophobic and aromatic Phe and Tyr in the disordered low-complexity region, that may promote coacervation by forming intermolecular hydrophobic interactions; The GLEBS region mediates interaction with BUB3; The microtubule-binding region is required for efficient loading of BUB3 onto kinetochores and proper mitosis.
Sequence:
MGRKKKKQLKPWCWYCNRDFDDEKILIQHQKAKHFKCHICHKKLYTGPGLAIHCMQVHKETIDAVPNAIPGRTDIELEIYGMEGIPEKDMDERRRLLEQKTQESQKKKQQDDSDEYDDDESAASTSFQPQPVQPQQGYIPPMAQPGLPPVPGAPGMPPGIPPLMPGVPPLMPGMPPVMPGMPPGLHHQRKYTQSFCGENIMMPMGGMMPPGPGIPPLMPGMPPGMPPPVPRPGIPPMTQAQAVSAPGILNRPPAPTAAVPAPQPPVTKPLFPSAGQMGTPVTSSSTASSNSESLSASSKALFPSTAQAQAAVQGPVGTDFKPLNSTPAATTTEPPKPTFPAYTQSTASTTSTTNSTAAKPAASITSKPATLTTTSATSKLIHPDEDISLEERRAQLPKYQRNLPRPGQTPIGNPPVGPIGGMMPPQPGLPQQQAMRPPMPPHGQYGGHHQGMPGYLPGAMPPYGQGPPMVPPYQGGPPRPPMGMRPPVMSQGGRY
The following text describes a protein:
Function:
Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Golgi apparatus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole.
Sequence:
MAVNVYSTSVTSDNLSRHDMLAWINESLQLTLTKIEQLCSGAAYCQFMDMLFPGSVALKKVKFQAKLEHEYIQNFKVLQAGFKRMGVDKIIPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKEYDPVAARQGQETVAPNLVAPVVNKPKKPLAPQRPIVAQRTPATPKGSTGMVKKAAGDDESAGLIEQINVLKLTVEDLEKERDFYFGKLRNIELICQENEGENDPVLQRIVEILYATDEGFVIPDEGAPQEEQEEY
The following text describes a protein:
Function:
Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis). Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D-galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer (LacCer).
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MISDKVVKQETRTNESSKMGRTTVLRLVDRQAPSILRSLFYLILVCILVLAVDVMLLQYSKNSRSNQLFGYDNMGMPQRRSRPSLDSEEDSRSMRRPMRHKVKPDPRGPLPSLAVPINRAYFESSNVTCRKGYARTRLQNLYGDRFDPDIPLFVDSSFLDRPNAVNLPMPFGFRDAERTVLNILKHMPQTEIPEDIPQDSCLRCVVQGNGGIASRTRLGEVIDNFDVVFRLNSAPTINHENDVGRKTTFRMAYPESAFRRPEQYDPGWTFVLMMFKPLDLVWLETIIRGRKMNSRDGFWKKIPLSVPKPTKDFRIFNPEILQDTASMMGYQLNDGKANKNIPTSGMLAIMMGVRLCDEVAVAGFGYDPNKPGAALHYYDSLPMREIWKSWTHDIHHERGILRLLKQQGIITDLSGGIR
The following text describes a protein:
Function:
Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MSATETSVRSRAKSHSDAEDDNDRDAVTLRRTETNSRPLRDRSRSHTSIGSFNVDLKRLLGLGAFGFFVALLFIFNLVNPVREANRARGLVRSSPTSELMDTLQSEGENKESLYWGTYRPRVYLGIRSRTPRSLIAGLMWIGGNDGKSFLRHVRKDSDELSIYSWAHHDDYNFGHQVIVDHDMNLATSFFKSKGEDSGYGGDWVVRIDVRSHKYSHKSKRNEEFWRSAHLFFYLADEDGNALTLGGDNLGIRESSPLASGLRTDIGSWQLHLKSRGDVEVHYFGFKMPHTHNLSDIVQEYLEPQVRKFGPLQLPDISDKSPNILVFQISAKIPFKTDIAFISGTDLESSRVEERVSSLTGTSLTSQLMEKQREFDTKFEKSFDQPDKIDQAADEFDKHAPPGFDKQVVSQALGFIQKAWGNAQRFVKDAQNGDTHTAIHHAVTEYKQFLFNQSAKLWVDQYPKVQSVAEKASSAASYWSQKYKHVVKDLTLKGYNISGLGYLPLVPIDKKMTKAPKHGEARK
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MERPHKLEEKWTGKHIAPGEKIEHFELDYGGKRDRWNGYDISSYAHVSELYEVRDEAKRKYLKEKQLRKLEEKNNKDNKAVGDSDKEDCEDALKVDETKVNKSKEDTSKYLLNLDVNSAHYDPKTRSMCEDPFPDMDSNEKFYVGVNQNRVSGQVLEFKKNNIHAWEAFEKGHDVHMQAAPSQVEFLYKNYKINKEKLKVQSKGDVMEKYGNESSDDTLPRELLLGQSEKEIEYDRAGRIMKGQFKAIGLDESEYFTSLEETKNNNSYVTTARGNLASMFFGKLSLTGSNFGEPKDSMNSLVSTKVNALMANSTDMDEKFAMREQNIKALKKSVDDKNLYIAQLMNKLEAYKPGVRKASSFIDRMKEEREFKKYMTLKTKESMAVKASSVKVTTKKKVKEDKGSRQYPKEDKCHPTLKELEAKVYPFLDSDVPMLPDELLVKKIIDLPKLKRPEKINKVNDPKYCKYYRVVGHPTGKFFIFKDKIITLFRSFDPVGVDFLRKTLKESLVTDNKAKVNDDDDGWTLVSRKKKRHQAILGIRLFKPRVMKNNAEHLRPPKSVKFDTRKKIDGALSRKDQSPITLYEFFPEKFLEDSQIDATHVITSTEEVNERKGGHCPTIAQDLHANREVESCCAYVKDGKVVKINADVNPFTETESYFADAKFYLNSCELGMEKPTLSNPTNVVAKEVEVQRAAVKMPKERIEKFSTKISSSKGDMHTKMDEEHLIFHYIPRDSRKEGQPLLEVCTQQSHPPRRETSHKPFQDLKKIMTIPIIQVPSITPELLGSNTLAHQIKGQFG
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNALQSVKSFFLPTSSADWWVQFRKWEHLCCPKQPTVRLVFLFLFFLLLELTVFAITLLYVPSRMHTGSFFLDNGVPAILIIATTGSVVKLSHMLSQRHRIGAISDTLQQFDHTIQMLDFRMKCDEIVYWTAGWSITFAITTLIFSVTIKVFGSVVFEHVGTGLMIVFINITNIPYSVFTVWFIVCELCIRCRMKLLHSLLDGGMRSMAPSRRIEMVKRSSQLLAGVTNLHADLSSIVGHVSAIFCVQVTISLSAFTILLIFCIFSYYRAAVVMGEIETNFAWLTICWSLYNSCFQIPKVLFGAWIRQGSNQLTKLVHHHLRHADEFMVQNQQLEHYSLTIRPWYYTINWPVYATVIGYISTYVVILIQFDSKTLDITRATE
The following text describes a protein:
Function:
Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity).
Subcellular Localization:
Cell membrane; Lipid-anchor. Cell projection, stereocilium. Note=Colocalizes with WHRN at stereocilium tip during hair cell development. Colocalizes with PALS1 in the retina, at the outer limiting membrane (OLM). Colocalizes with WHRN in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies, and at connecting cilium (CC) (By similarity). Colocalizes with NF2 in non-myelin-forming Schwann cells (By similarity).
Sequence:
MTLKASEGEGGGGMRTALSDLYLEHLLQKHNRPEPVSPQLSAVMEDMYTNGPAALGSPAQTQGQEARKVRLIQFEKVTEEPMGITLKLNEKQSCTVARILHGGMVHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQNRLPALQMFMRAQFDYDPRKDNLIPCKEAGLKFLTGDVIQIINKDDSNWWQGRVEGSSQESAGLIPSPELQEWRVASGAHSAPSEAPSCSPFGKKKKYKDKYLAKHSAIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKSALLSQNPDKFAYPAPYTTRPARKSEEDGKEYHFISTEEMTRSISANEFLEFGSYQGNMFGTKFETVHQIHKQDKVAILDIEPQTLKIVRTAELSPFIVFIAPTDQGTQTDTLQQLQKDSEAIRSQYAHYFDLSLVNNSVEETLKTLQETFDQACRSPQWVPVSWVY
The following text describes a protein:
Function:
Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.
Sequence:
MIKSETVKQILEHYRVIWALSHAQALLGWDSETYMPEEGIKGRAVARAEIAQLIQRFMLEEKFVKLIEKAEEEKDLTDVERGIIRVLKRDLKFYQKVPPEIVKEFTKVTSEAFIAWRGAKEKAKFDIFAPYLERIVELSRVIADKLGYEEHPYDALLDLYEEGLTSRDVESVFSVLEPGIRKLLGKLESIGWPKSHKLEEEPYDKTKMEAAIREVLELVGYPKGRFRIDISPHPFTIGITTPFDVRITVRYRGVDFKEPLFSALHEYGHALYELNVDESLAMTPVGTGVSLGVHESQSRFMENVIGRSREFVEKIAPILRKHLDFLSKYGNDDLFYYFNVVRPSLIRTEADEVTYNLHILLRYKLERLMITGEVKVNQLPELWNSEMERLLGVRPKNDAEGVLQDVHWSHGSIGYFPTYTLGNVVAAMIYYKHGRIRSLVAEGNITAIKEYLREKIHKWGSVYPPKELLMRSFGEAYNAEYLVKYLEEKYS
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MGVLERWLTELGVAWVLHLGSDASAWDELADEHTCHAARSWIRALCKITETIRSMAATLFADRGSMSLLPSSIYEEEEGDSEAGGSVLELLLFARFIQETMLKMVAFVDFIVSLLDPHGVPVQALHQKIHILLRVHGALSDALTEIKMLFLSMLPSAEVERIRGGLVNLLYAKNAKVRESIRSRLENIRISCIMEPLVDDDSTGAQTPQVSSDIDKVTLSVMAHITFLLENYSPVDPIVSEAAILGNMIIEMVCCLQERIVLMSKTFQDQSLRFLFLLNNFNFICHSLHNNTTGFCFLQVHVTSLLEKVEHYLESYLQVSWGPVLSCLFNTTPVCFGKNYSLLPKFESEFQKMYTTQMLWKVPDPEMRKRLRKAITEKIILGYAKYIEDNNVTTPRSTTHNLEEMLQELFEG
The following text describes a protein:
Function:
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MNDHHLNHRIINNINASSSSSSSSSPVQTNININSANNTNNNNNNNNNNNNNNNNNNNNIDNKWKKNLYEKQPYSDNYTDETFLIGLVQNANFIKYDFWTVVLDSFTVSQQITSVILFAIIFFHSLKHTLTLPFLVAMAGGFLVLGYIAIIIIDPSANFLSIRSSFLHIILLFGTVYGLSPVLRTLTNSFSDDTIWALTFILLLAHLFFHDYGYTNNESQKFSAPVSLNAAIFASVLLGSRLPSNIHVFVLISYAIETFALFPIFRHHLKRHSMELHVGLTVILCVTCSLLLLGMSKLLALIYIGIIGTITFVCPLWLIFIQKYKNEINGPWDEASVISQSGGEF