lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as an activating receptor in myeloid cells and mast cells; (Microbial infection) Acts as a functional murine norovirus (MNV) receptor. Primary determinant of MNV species tropism and is sufficient to render cells permissive to infection by MNV. Can render nonmurine mammalian cells susceptible to MNV infection.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MWQFSALLLFFLPGCCTAQDSVTGPEEVSGQEQGSLTVQCRYSSYWKGYKKYWCRGVPQRSCDILVETDKSEQLVKKNRVSIRDNQRDFIFTVTMEDLRMSDAGIYWCGITKGGPDPMFKVNVNIDQAPKSSMMTTTATVLKSIQPSAENTGKEQVTQSKEVTQSRPHTRSLLSSIYFLLMVFVELPLLLSMLSAVLWVTRPQRCFGRGENDLVKTHSPVA
The following text describes a protein:
Function:
Negative regulator of epidermal growth factor receptor (EGFR) signaling.
Sequence:
MESLRKWFYRPKRDDKSLLAQFFFADEALNIIANELDSFDGRKDPGRCTTLVNQLRQSQDKVLTITNAIMDVLIGDERANRDFRVKFPEDVLQENLAGQLWFGAECLAAGSSIMNKEAESTAMRPLAKAVTKSLETVRNLLRDTCLRNNTPNGPIKLDSNELVTEMLLESLKIFDKLFAEFELAYVSAMVPVKSMQEYELQELIGVLFSETLQRALKMKLLSQEMVDDCDPALMFTIPRLAIVSGLLIFPSGPLCVDRPIEEMSNMFRPFRTLLHKIRELLWTLNKRELFMLEKLLCDNEQISDVKSFSDSDFRYDFIDQFYGDLHREEVVVVAKGEVSVNKDKPVVYPLETDTPSTSGYLIPNSIAHDIVVASVVEPQPGDSPPDHDSLEVISVAAATLSSILAENESPNDSGVCTENTSLDRSPSLDCQCGVGCKCRKTSPRIKGKGKLPPTLPRKKRQVEDDASSVGSSDTSSFNSNDDEEIALAMQAAQIAEVRSKYRSSEDLIHRLFVCIAGVADQLQTNFASDLRNILKSVFLMNTSDAAVDTTSLEASLEYRPSEHDVIENNEFSVDPNILAQEALFDTNVYFHLDPESEDGEYTNHPRQEPSQANSSSERPPIWIPDVEAPKCMSCGMNFTVVKRRHHCRNCGKVFCARCSSNSVPLPKFGHHKPVRVCNKCFIYNLTPFTM
The following text describes a protein:
Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes degradation of interleukin-22 receptor subunit IL22RA1 in resting and IL22-stimulated conditions by facilitating its ubiquitination. Functions as a cell growth suppressor.
Sequence:
MEIRLPDLALKRIFSFLDLFGLLQVSQVNKHWNRIADSDYLWRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIAFETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPMPQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRKVSDSSILVMYSLNT
The following text describes a protein:
Function:
Required for proper chemotaxis and phagocytosis; proper spatiotemporal control of F-actin levels in chemotaxing cells. Negative regulator of the PI3K (phosphatidylinositol 3 kinase) pathway. Predominantly phosphorylates serines and threonines and tyrosines at a lower level.
Subcellular Localization:
Membrane.
Sequence:
MDLNLIKRYIENDLPDDKEQLIGYYTQLKQILNVLSDQKQQQINGTNNNNFVSVNFEIIESIEEKMKTIESTFNDVLNLSENSPPSPMFISNNAGNEISSHQPQSGIVIDGNNKTNVTAEILVDNNHQQQQQKEQQQVQQQVQPQHQVQQNSELTDEQKQAISRNQQVVQQAISNMEVKKRSSSHRHSGPPEIPPEEIKFDSRTDLLGGGAYGKVYKATCRGKKVAVKVPKKQTLSESELKSFKNEVDIMRNIFHPNVVLFLGACTKPGKVMIVSELMQTDLEKYIHSDNPPPFYQRMKMCLDASLGINWLHGICNVIHRDLKLANLMISKDKTVKIGDFGFSQVIKTGTTLSDQKGPKGTALYMAPEVMMKQEFNEKADVYSFGLILYEMATCEELFPEYSEIDPFYDAICNKKIRPIIPSEYPVSLKSLISRCWDHDPNKRPSFNEITQRMEDVLVDVAISNEAAARFWKNNLTKSEPDTVKWSEFVTKLSHATSVQLAPLRALKKYFCNTSLDENISIEKFDMMNKWFGNFFDEKVGPSIINEMIGLLDQQWFHDITRDTSEKRLRGRSDGTFLIRLSSNDPVNTPFTISKNKNSKPVHKRVSRDYVAASQEYPLGYKISVPLDGNVLTFNSIITMVRKLREIGNLGNACPPSEINVPYIFD
The following text describes a protein:
Function:
May be involved in the transfer of 2-keto-3-deoxy-D-lyxo-heptulosaric acid (Dha) and/or 2-keto-3-deoxy-D-manno-octulosonic acid (Kdo) on the homogalacturonan backbone of rhamnogalacturonan-II. Required for efficient pollen grain germination and pollen tube elongation. Does not possess sialyltransferase activity in vitro.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MKLLHLIFLLALTTGISAVLIYIIGVSNLYESNRFTNEDLEALQSLQNGFQKCVSANGLGLQAAMGRDYCKVSINFPKDTVPKWKDPKSGELEGLSYEFDLCEAVATWEQVRNSSTILTKEYIDALPNGWEDYAWRRINKGIQLNRCQNKSLCIEKLSLVLPETPPYFPRQFGRCAVIGNSGDLLKTKFGKEIDTYDTVLRENGAPIQNYKEYVGEKSTFRLLNRGSAKALDKVVELDEKKQEVLLVKTTIHDIMNKMIREVPIKNPVYLMLGASFGSAAKGTGLKALEFALSTCDSVDMYGFTVDPGYKEWTRYFSESRQGHTPLHGRAYYQMMECLGLIKIHSPMRADPNRVVKWVPSRSTIRSARIAAEKLLRRVGAGSADPLASCSIVKKRNKNKRPMVSHLRKPVSDHQKFVRSTSMYPVEHSPGHGQLCITPAD
The following text describes a protein:
Function:
Catalyzes the specific cleavage of pyrophosphate.
Sequence:
MAYNSNSNNNNNNIVVVFDFDKTIIDVDSDNWVIDELGFTDLFNQLLPTMPWNTLMDRMMKELHDQGKTIEEIKQVLRTIPIHPRVVPAIKSAHDLGCELRIVSDANMFFIETIVEHLGISELFSEINSNPGYVDERGTLKISPYHDFTKSPHSCSCGTCPPNMCKGLIIERIQQSLAKEGKKKMIYLGDGAGDYCPSLKLNTEDYVMPRKNFPVWDLISQNPMLIKAAIREWTDGQSMEMILIGTIEEIRLEEEKEKMLTSAENNCKMQTISIGINNVHHEPILPRALRVSQSS
The following text describes a protein:
Function:
Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MAGSAPWSRSPTRGGLCSASPRPPLRSSAALLGSSAPPLPGAARGGLCSAPRRAPGCGSRSRSRGPRCAAPPCAGSADAERGRPAGLRMRPSLCHQVYRVAVSVRGARRLVTCRRRRRRDPCQSPGCRVVLRGPEVTREGACSRKVGQTLTRRALCGKKCLRRGRRRLVFGMLYPAYYSYKAVKTKNVKEYVRWMMYWIVFALYTVIETVADQTLAWFPLYYELKIAFVIWLLSPYTRGASLIYRKFLHPLLSSKEREIDDYIVQAKERGYETMVNFGRQGLNLAAAAAVTAAVKSQGAITERLRSFSMHDLTAIQGDEPVGHRPYQTLPEAKRKGKQATESPAYGIPLKDGSEQTDEEAEGPFSDDEMVTHKGLRRSQSMKSVKTIKGRKEVRYGSLKYKVKKRPQVYF
The following text describes a protein:
Function:
May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (By similarity).
Subcellular Localization:
Cytoplasm, perinuclear region.
Domain:
Composed of an N-terminal domain, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.
Sequence:
MEFLPGPQHPPGPPTMDLEEPKGPEVPSENHPSNTQSALGPGGPVTLSEMELDTSSVQELVQQLEALPSDLGGPFPDGAPCPLHIATGQGLATQENPDAGGLLSAEAGGDDLLGLLRDEASSPAQSVPQDPAQTAPRLLQPPEDPDGDPGWMEGASAEPADSRSSSSSPEPWLETAPLVTQQEPPVGTQSRETLASCPAVTEVPGPCGPEELMDGVIFGAKYLGSTQLLSERSPAPSTRMGQAQEAMDRVKAPEGETQPMVEVDIFISTKRVKVLAADSQDALMDHALQTISYIADIGPVLVLMARRRLARRTTPQDRQRRLYKMLCHVFHSEDAQLIAQAIGQAFSIAYSQFLQENRIDPSQVGTQPSTAASHPHNGDLDHFCNSQNCREVCIQKRPGEGLGVALVESGWGSLLPTAVIANLLHGGPAERCGALSIGDRVTAINGTSLVGLSLAACQAAVREVRRLSSVTLSIIHCPPVTTAVIRRPHVREQLGFCVEDGIICSLLRGGAAERGGVRVGHRIIEVNGQSVVAMPHARIIQLLTETREIHIKTMPAATYRLLTGQEQPVYL
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MILSKLLTWLAFFITFCAAKPDVFSMVNNAGLIEVTDSTFSKVITGSQDYVVVALLTATQGIDCETCTKVDPEFRVLAKSHRKAFPNDKELVFVHADFQDNKNTFRGYNIRSIPNFWVFEPHTNAPHELKLMGDLSAEYLSESIASLVGKLIPIYRPHDYSKDVMSLVSLLIVVAFVTYYRKALLRLVHSRKLWAAISIVSVITFSSGHMFNRIRGTQYVQHNQDGSVSWMAGGQMNQFGAETQVVSLLYFVLSLSVISLAYSAPCIRGAKSQTIFVIAWLTIQVFLYSYLAYIFREKNGYYPFKLLL
The following text describes a protein:
Function:
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
Subcellular Localization:
Cytoplasm.
Domain:
The PRC barrel domain binds ribosomal protein uS19.
Sequence:
MELVVGRVVKSHGVTGEVVVEIRTDDPADRFAPGTRLRAKGPFDGGAEGSAVSYVIESVRQHGGRLLVRLAGVADRDAADALRGSLFVIDADDLPPIDEPDTYYDHQLVGLMVQTATGEGVGVVTEVVHTAAGELLAVKRDSDEVLVPFVRAIVTSVSLDDGIVEIDPPHGLLNLE
The following text describes a protein:
Function:
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
Subcellular Localization:
Cytoplasm.
Sequence:
MIFITGTDTGIGKTYVSSILAENLKKMGINVGYLKPVETGGREDTLTLKNILNTDDDLDLMNPINLKLPLSPNIAFDVENSPLTLDEIKEKIKNAYETLKEKYDFLIVEGAGGVCVPIKEDFLMSDLIKFLGLDAVVVSRPNLGTINHTLLTVEHLRNKGINVRGVIINCITDLSEVLYYEKTFETIEKVGNIEIIGIVKSREDFEIDFEKILR
The following text describes a protein:
Function:
Limiting component of the male-specific lethal (MSL) histone acetyltransferase complex, a multiprotein complex essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). The MSL complex specifically associates with the single X chromosome in males and mediates formation of H4K16ac, promoting a two-fold activation of X chromosome. Msl-2 is only produced in males, constituting the limiting component of the MSL complex. Within the MSL complex, msl-2 mediates the selective binding to the X chromosome and recruitment of the MSL complex via two different mechanisms. Recognizes DNA motifs that are enriched on X chromosome, named PionX sites, which are characterized by sequence features and distinct DNA conformation (base roll). Specific recognition of the X chromosome is also mediated by the formation of a gel-like state: msl-2 undergoes liquid-liquid phase separation upon binding to roX1 and roX2 non-coding RNAs, leading to nucleate the MSL complex on the X chromosome. Msl-2 is also required for translation and/or stability of msl-1 in males. Also acts as an E3 ubiquitin ligase: in complex with msl-1, mediates ubiquitination of histone H2B at 'Lys-34' (H2BK34Ub). Also catalyzes ubiquitination of msl-1, msl-3 and mof components of the MSL complex.
Subcellular Localization:
Nucleus. Chromosome. Note=Msl-2 specifically localizes to many sites on the male X chromosome.
Domain:
The C-terminal disordered region (CTD) undergoes liquid-liquid phase separation (LLPS) upon roX (roX1 and roX2) non-coding RNAs to form a stably condensed state, leading to nucleate the MSL complex on the X chromosome. The C-terminal disordered region (CTD) forms phase-separated droplets with either roX2 or, less efficiently, with roX1 non-coding RNAs; The MSL2-type CXC domain and the Pro/Bas region recognize and bind specific DNA motifs on the X-chromosome.
Sequence:
MAQTAYLKVTRIAMRSASNLSKRRVEELNSGLGELRQLLSCVVCCQLLVDPYSPKGKRCQHNVCRLCLRGKKHLFPSCTQCEGCSDFKTYEENRMMAAQLLCYKTLCVHLLHSALFGELAGMRPQVARELVPRIKLPPKTTQEFIREGSNISDTFDIFLPQPDLPFLKDMPTSLPAETPPTSAVTTPELPYDHHLNISDIEAEAAATAEQGHFSPLPLLPTGSRMGMLSHAGQIVIATESSESGFMDQAWTDQVDLSGTVSVSKYTNSGNNFAVSYVMPTSATTKFDPQELQIGQVVQMADSTQLAVLAAVEETVETSTQLTVLSTTVEETVETSTQLEVLTSAEEPNEISDQLANLQVEESDEALVEETVEEAEGTSIPSEVVAEHMEEDQHLDVHTSQSPTQTEMEEAVEEHVATKTQLGHVQTELQDAESLQKDFEDAKAAAEEAKEKEKDLHAISAELQKEDSDEPTLKRKRTRTLKASQAAKIEPVPSEVKTKVQSGKGALRRIRGKDKEEKVKPPKPKCRCGISGSSNTLTTCRNSRCPCYKSYNSCAGCHCVCCKNPHKEDYVESDEDDDLEDFEMPKDVPEPMTQSEEPVVAEPRQEENSMAPPDSSAPISLVPLNNLQQSQHPLVLVQNEKGEYQGFNIFQGSKPLDPVTVGFTIRVQLQHTDGFGSLPQYAYIMPTIDPPNPPAPSLSPPPPPAPDREVIEPPAKKFRTSRTRRGRANFSALDTVDELVSGGSRSNSAAGDRSSATDNAHSLFEEIMSGSDDL
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MFSRSVLSTARSYYTSTSQPAQATHHLITLVRSPIGLTKDSKQTLVALGLHRLRQSVLQPFGEVTAGRILKVKELVQVANVTKEEGEALMKRRRGEGNGVEPSGRVYGGGKGLVESEI
The following text describes a protein:
Function:
Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Note=Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER).
Sequence:
MEPWVPQTQGRTTGPSRDTNRGLQSGHYRPRLHSQYSGDKYHQWQDAHKNSKSQQDLRDDHQQSHSVSRSGEWSQPVSGADYLKGSYPSHLYSRSGYGDPYQRYHTPTPRDEYAYGNYYYHGHPQLLPEERVARQGSPYIWHEDHGDQRYFGEHHREKHNGTFGANSDTQFQFTSKNPYRDSPASVSGQEQPGEFFPESEAQKQKPLLTSKSSLLQQHESGLSSSSYELSQYMTAAPEEYEPMVSAAWRPIQADDTSATVPKAPMRFYVPHVSVSFGPGGQLVCVPPNSPADGQTALVEVHSMEVLLNDFEDQEEMRAFPGPLIREDIHKVDIMTFCQQKATQCLKSETPGSRDSALLWQLLVLLCRQNGSMVGSDIAELLMQDCKKLEKYKRQPPVANLINLTDEDWPVLSSGTRDLLTGEIPPNVDTPAQIVEKFTKLLYYGRKKEALEWAMKNHLWGHALFLASKMDPRTYNWVMSGFTSTLALNDPLQTLFQLMSGRIPQAATVCGDKQWGDWRPHLAVILSNQAGDTELYQRAIVSMGDTLAGKGLVEASHFCYLMAHVPFGHYTVKTDHLALVGSSHSQEFMKFATIEAIQRTEIFEYCQMLGRPKSFIPSFQVYKLLYASRLADYGLASQALHYCEAIGAAVLSQEGSSHPVLLAELIKLAEKLKLSDPLVLERRRGDRDLEPDWLVQLRRKHKDLEQNRTGAPRDPDSTPSDIYGAGGTTDTPYPDLSGHQNYSEDSEYSSTLWSTAEQTSLTNPLAQQSFPLQRDTYSGHMGTPVPLYSVPATHLAVTSGASGSSVAVTGTPGGRVGEDMLRTHPAFGENTMTQEPLEDPDGLEVISSLQTPAAPRVPSFSEDSAASAKEDEEGSSDGADKPSHPDASQKGKLGDGKNTKSSGFGWFSWFRSKPASSVSTSGDEDSSDSSDSEESPRASSPHHASPGLSPTPPLTSPSLPGASTFSRGTGGSILQGSSNSSGIAEGMGIGGFSGTQGVSSEFYSQPGALPPPPTLQGAVPLYNPSQVPQLPTASSLNRPNRLAQRRYPTQPC
The following text describes a protein:
Function:
Catalyzes the NAD(P)H-dependent reduction of ketopantoate into pantoic acid. Prefers NADH rather than NADPH as the electron donor.
Subcellular Localization:
Cytoplasm.
Domain:
Cooperative binding of CoA and ketopantoate induces a closed inhibited state by interacting with the N-terminal and C-terminal domains, and seems to facilitate the disulfide bond formation.
Sequence:
MRIYVLGAGSIGSLFGALLARAGNDVTLIGRREQVDAINKNGLHVFGAEEFTVKPKATIYAPEEPPDLLILAVKSYSTKTALECARQCIGRNTWVLSIQNGLGNEELALKYTPNVMGGVTTNGAMLVEWGKVLWAGKGITVIGRYPTGRDDFVDEVASVFNEAGIDTSVTENAIGWKWAKAIVNSVINGLGTVLEVKNGHLKDDPHLEGISVDIAREGCMVAQQLGIEFEIHPLELLWDTIERTRENYNSTLQDIWRGRETEVDYIHGKIVEYARSVGMEAPRNELLWVLVKAKERINRGKTRNISEGC
The following text describes a protein:
Function:
Serine/threonine-protein kinase which regulates the localization and the function of the septins during mitosis. Involved in the formation of the septin ring but not the basal septin band. Phosphorylates septins CDC11 and SEP7. Required for the transition from pseudohyphae to hyphae. Acts upstream of IRS4 and INP51 in regulating cell wall integrity responses. Involved in propolis-induced cell death.
Subcellular Localization:
Cytoplasm. Bud neck.
Sequence:
MPHSRQPSISSSIMSQSNHNHPQKIGPWKLGKTLGRGATGRVLLATHQTTGQKAAVKVVSKSELQDEETEKNGDGLPYGIEREIIIMKLLTHPNVLRLYDVWETSKALYLVLEYVEGGELFDLLVERGPLPEVEAIKYFRQIILGTAYCHALGICHRDLKPENLLLDSQLNVKLADFGMAALESNGKLLETSCGSPHYAAPEIVSGLKYHGAASDVWSCGVILFALLTGRLPFDDENIRNLLLKVQAGNFEMPVDEVSREARDLIARMLEVDPMRRISTEKILRHPLLTKYPMSNEDLISEKSLPHPQTGYKSLGSVRNIDKQILSNLTILWNDRPEEEIVDCLLKDGSNPEKTFYALLMRYKHNQEDNTNNNSPKKSTSFNNKVVRSGSKYSLNGTPRRKRASHISVSRPTSFQYKSNPGAGATANRNSVARHSVASSANNSPRKSPYKSPYRSPYRSPYKSPSKRYSYNQSPTKSPYGRRSNSQRQFENEPLKAKPRNIYNEIVDAQSNFSLPPSLPPSLPSKDSRYMIDEPNQPQLQQPALSQVPENPIVDESPDLMQSAKISSGKRNSIIGKNNNNSNSNKRMSKRKSIRASMTTGLKRNSITMKLLSTYAKLSGDDDWEYMDKQTKRTSATFAALCDKIFNQEDYDEEDEQLVDPEEKEAKEYERLMELERKKHEAELKARRELEKKKRRQKRRSILSSKKLSIIVKNDADPNNSEQELVDEGIKQPKRQSKNLTALRALSEGNHASEELTLEDVENLKRRSASQPVPKRRQTPVLTRRPVSRLDPLWQAHENEQLDRAKDALEQEWRDSQKRSSTVSRKKVNRESMISVMDDIVEEDQGRVNRRSTRNTYYERERDYELPEPTVEDSNLTDDYMTEIRKSRLLNSQLNVRDPLNEKRKSEPKTLISNVQIPSVTRKSRNFTTSNKRLSVLSMYSTKESYRDLNSIINSPDENPEQHQNMNKPALRTSIADRLDKAGLAEPEYETETDGEDKVSVIDLDDHLADRRTSYYDGSGKRASRASTTKRYNVHSSSGQRPKSKVPDLPKNDYDDTFVSNSDEVHKRQYKSMVSDESSASDDVFDKIKLPDGKSTKSSIDELANGTSTSGHRKPKIRHSQPGPEMLIPHLNGGIESSQPMSKVRGNNSSGHDDSVPPPPPAHKVNKKPLDDKTNFPPPEVDPKRKGSFFRKLSWGSKKTIENNTNAATNTTTQQQLPSPAESKEEKPKSSFFRWFSSSNTPSAAEIRKFNTILPKHEMSTALFALLNSWSNFGLKDLRNDQVGYYITGAISKHNSFNLKSCKFRIKINQRDFNQKSEIVCVRVKGSKVTTDTLFSEIEKVLLKEGVLDK
The following text describes a protein:
Function:
Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
Subcellular Localization:
Nucleus.
Sequence:
MAHNKIPPRWLNCPRRGQPVAGRFLPLKTMLGPRYDSQVAEENRFHPSMLSNYLKSLKVKMGLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERNPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARPPGIYKGDYLKELFRRYGDIEEAPPPPLLPDWCFEDDDEEDEDEDGKKESEPGSSASFGKRRKERLKLGAIFLEGVTVKGVTQVTTQPKLGEVQQKCHQFCGWEGSGFPGAQPVSMDKQNIKLLEQKPYKVSWKADGTRYMMLIDGTNEVFMIDRDNSVFHVSNLEFPFRKDLRIHLSNTLLDGAQPVGDCDFNIRLQCIEREIISPRHEKMKTGLIDKTQEPFSVRNKPFFDIYTSRKLLEGNFAKEVSHEMDGLIFQPVGKYKPGRCDDILKWKPPSLNSVDFRLKITRMGGEGLLPQNVGLLYVGGYERPFAQIKVTKELKQYDNKIIECKFENNSWVFMRQRTDKSFPNAYNTAMGEYDSLPVFVTLRERERSERASAQERARMCILRFQNQNVFCLMGHGVIQTPVLAGWERGYDCQLHLAYGFPSVGLCTYAHVPKREV
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Sequence:
MFYICDERQNVSSEAQKLFNQYFSSSRKRQDIIERLLTDILDKIQLYFGRLQIKGEISNEIWPRIFGSNLKLCCYLTDYFPENPQIREIFEATNLSEYTKVGHGQFNKSITPFLRSSIYQFLTTSLLLNFDTPTINVIDIYKTETNVDCQIELIKLISELLNQNKVDHTKLQEAILSSLLNYEFPEKIGMMDLILQVKENDFLSKFVTPALQLKIFVLSESYFDIFTRTNIPEMKDLLVEAFITAISSTNNSFLTTCSLAKFSVISEDDRINEPLFESNDQRIPYFLKYIGKERSIEWLRRRKTITTRSLLTFINNFGENSIREVYKTINDIPIITENEILRIMSQANDNEDESMDDFIVKRQKKKKNKKNPQKVTNVSIVPKKKKESWGEKWRRRNQTNFDDDEDSDDEADILLLRNQEEEENESDIIHKTVEKSETNDSSSQAGDTKPDFNDESFLKFFVKFANQDDVKSYAKSTPNLIKIIKNWQKPLEILRIPEIKEKIFEILEEDFSLSQKILNIFENDEEVKEYIQEMATEALESGKAVDKSVFNHIQTSDEMIEQFILSDQIESITPDHPLLEQCVKYINDHLATHDPIDLAERAFDLIEKGEVKPKSFGQKVTKYPEFYCELWSFCGFDKFDLHDVCLLLDSIILKKMPWIDCFIYLRTVNWMSVPSTLQNFIMNNPLMYDVAHEMELLYALSCISAATSIKCDANSDAISIIASMRCPPRKIVSEDPDIIDHQIEWHQIRVQTSDLKIENPDYHSLRRCVVYLKQNLPVLSTFEPLIPYLERSLRKANHFTYFLVCKILNLVKDACKSLNNLNLIAKQMIELSVKFAPFPLIIQEEISGAFEVFKLIGKEEFQKMILNSSSCFTHKNANHLMTLISPLFVYFNAWDLVESKINGKLDLSLTISWIFVSNLIVLMPDEKKSQLSLSLSHDLMKILSKIEYKSSEFELLVTTFPNTSNSWLNTQEITIKKEILNYAAKVITPRLFKKLQTKLVQTRMEKISYRFNQSNNSIKALYQDEKNAVPISLEIILPDSYPFGNVTVKVDFGNDTLSDKCYHEVLSELRKLETISGAIRAWYSFVIHQVLENSPCIICLSYFDRGVAPSMQCSSCHNEFHAHCLKQWFARCAEKTCPMCGSKWK
The following text describes a protein:
Function:
DNA repair protein required for FANCD2 ubiquitination.
Subcellular Localization:
Nucleus.
Sequence:
MTSKQAMSSNEQERLLCYNGEVLVFQLSKGNFADKEPTKTPILHVRRMVFDRGTKVFVQKSTGFFTIKEENSHLKIMCCNCVSDFRTGINLPYIVIEKNKKNNVFEYFLLILHSTNKFEMRLSFKLGYEMKDGLRVLNGPLILWRHVKAFFFISSQTGKVVSVSGNFSSIQWAGEIENLGMVLLGLKECCLSEEECTQEPSKSDYAIWNTKFCVYSLESQEVLSDIYIIPPAYSSVVTYVHICATEIIKNQLRISLIALTRKNQLISFQNGTPKNVCQLPFGDPCAVQLMDSGGGNLFFVVSFISNNACAVWKESFQVAAKWEKLSLVLIDDFIGSGTEQVLLLFKDSLNSDCLTSFKITDLGKINYSSEPSDCNEDDLFEDKQENRYLVVPPLETGLKVCFSSFRELRQHLLLKEKIISKSYKALINLVQGKDDNTSSAEEKECLVPLCGEEENSVHILDEKLSDNFQDSEQLVEKIWYRVIDDSLVVGVKTTSSLKLSLNDVTLSLLMDQAHDSRFRLLKCQNRVIKLSTNPFPAPYLMPCEIGLEAKRVTLTPDSKKEESFVCEHPSKKECVQIITAVTSLSPLLTFSKFCCTVLLQIMERESGNCPKDRYVVCGRVFLSLEDLSTGKYLLTFPKKKPIEHMEDLFALLAAFHKSCFQITSPGYALNSMKVWLLEHMKCEIIKEFPEVYFCERPGSFYGTLFTWKQRTPFEGILIIYSRNQTVMFQCLHNLIRILPINCFLKNLKSGSENFLIDNMAFTLEKELVTLSSLSSAIAKHESNFMQRCEVSKGKSSVVAAALSDRRENIHPYRKELQREKKKMLQTNLKVSGALYREITLKVAEVQLKSDFAAQKLSNL
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion.
Sequence:
MTSNTVRVPYSHELYAMSRHVVFRAEKEHKAAVECKGKHDWPEDCKPESEALVRATNKLYKEIMEKSPEEFKEYAQCLDWYGLRFSRCRDKQTAFEKAFPIVDAKK
The following text describes a protein:
Function:
Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation.
Subcellular Localization:
Nucleus.
Sequence:
MFLDKCEGDLCDLREDGSTPTPGTPEGEDYKLPTKKHRRNRTTFTTYQLHELEHAFERSHYPDVYSREELAMKVSLPEVRVQVWFQNRRAKWRRQEKLESSTSKLHDSPLFSFSRSPIATSMGPLSTALPLEPWLTSPISGTTTIHNMPAFMTPSQAHLPTFPSHTFLNSGPPMTPIQPLSSAPYQCMGGFVDKFPLEEMDQRSSSIAALRMKAKEHIQTIDKTWQPI
The following text describes a protein:
Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus.
Sequence:
MVYYDLNIDSSLPEPKIKSMLSLHTKYGYDSVAITHTVEGKIGYKDVCKIKKIQIEDDSEKSTSSGWMKMGDSNKTIKQYTRLQVICKTMAEFQMITANNPVVQSYDIISVVPYDVSVFNAACNSNEIDIITIDTFSKFIIKPERVRQCIAKGIFIEILYGNLFGIDADRIAFFQIASSLVRSSFGKNIILSSSGKSSTTLRSPYDLSNLGHLFGLTFDQAKAAVSKHPHTAVLHAITRRTKGIATVTDPNLLKDLELWKLERKEDTQPTNNNIPHEKHINKESTGKETIPKPTTTTTTTTTTTTTAKTKTPTPTPTTEKTPSIPTQPPQKPTAKSNKKTTTNTTSTAQKQGKMDIDIDNNKRKRE
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MKHNASSALLSAFQGLRISSSATPFRAASLATSAVRRPIAPTPVSVASHVRLFSATAIQAGSWLEPNLNRKKKMMKGRPRVPTGGSTKGTTVVWGDYGLRMRDHHRRISAQQLKLAEDTIKQRLRGQKYRLYKRVACNVGVYVSGNEMRMGKGKGSFDHWATRVAVNQIIFEIRGQLHEQVIRDAFRLAGHKLPGLYEFVKKGDPPVVGITKLEDGLTVEDLKNPRKKLLMPEITQSAASTSSTAAPPS
The following text describes a protein:
Function:
Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus.
Sequence:
MSVVTIQIGQYGNQIGHEFFSTLAKELFCESENCNDNKNKDTENKTAQNIKLNQNRILKDSFEEDGLDIFFQNSAKNRNSYVARCVLIDTEAKVVDRVLSSSLSSISVSSDMLNKTWSYNKKFKISHKYGSGNNWAQGFYSFGAKVVDSLDELIRHQVEKCDRLGGFLSMMSLAGGTGSGLGSYLIRHLREYYDKSAIISQVIWPYRSGEIAVQSYNSILSLAHIYEAVDSIVAFSNDGMQKTCQLQLGLTKVSLSDINRLISMNLVHAFLPSFTDGLIGSYDCLGDYINHLTPHPDLKMTSLMTSPMVSDLIRPFTVYSWASTLKELGRLYNLQATPGNQFDPEWQLKYDGTLNNSKAFAHILINRGFECSLSNNHNTNSHNKYNSKRNNNNNKVAVKNEFLKLKSSYPIYQPNGFLFKHHQRPIFNQHMSSLLAYNDVNQMYIVDEALEKTCKLFENRTYVHQYERHGCAVDDFVDSILMVQQLLSNYARL
The following text describes a protein:
Function:
Plays a role in the regulation of phosphate uptake.
Subcellular Localization:
Cytoplasm.
Sequence:
MLRSQFEEDLEKLHNQFYAMGQEVLSQINRTVRAFVTHDRDLAKEVIEDDAEVNEYEVKLEKKSFEMIALQQPVSQDLRTVLTVLKAVSDVERMGDHAVAIAQATIRMKGEERIPAVEEEIKKMGREVKSVVEAALDLYLNGSVDDAYRVASMDEQINHYFETIRDLATEEIKKNPEAIVTGRDYFQVISYLERIGDYAKNICEWVVYFETGKIVEL
The following text describes a protein:
Function:
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAPFVLAVPSKGRLQENTEAFFARAGLKLSKAGGARDYRGTIAGLDNVEVAYLSASEIAAQLSRGLAHLGVTGEDLVRENIADADKRVSLIEGLGFGYADVVVAVPQAWIDVRTMADLDDVTTGFREQHHMRMRVATKFVNLTRAFFQNHGITDYRIVESAGATEGAPAAGSAELIVDITTTGATLAANGLRVLDDGMILRSQANLVASRDADWSPQARETARVILDHIAARARANKYREVRTRFRQCDAALLGEAHSRFGVEAPFGGPTSSGMLTLHCPPGQLYALASFLREHGAETVSVVSLDYVFDRENPLFAKLEAFLRR