lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in mRNA export coupled transcription activation by association with both the AMEX and the SAGA complexes. The SAGA complex is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Involved in transcription elongation by recruiting the THO complex onto nascent mRNA. The AMEX complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). AMEX participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (By similarity).
Subcellular Localization:
Nucleus, nucleoplasm. Cytoplasm.
Sequence:
MTIFNAVDKFTMMSGDRVKIKDLLSSRLTECGWRDEVRLLCRSILQEKGAISSFTVEQLVTEVTPRARSLVPDAVKKELLIKIRTIFDENEADDIDPEEA
The following text describes a protein:
Function:
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.
Subcellular Localization:
Nucleus speckle.
Sequence:
MDPMFNINFQSATMMMPEFPPVQGQKPTPYDKKKDPNHVKRPMNSFMVFSQAERKKITMAQPHLHNAVISQQLSKKWKDMTPEEKDPYVKEADKLKMEHALQNPGYKYQPRRKLKGVPSKSTVSDENSEGKKATPQRKNAQPMAQIQQYPGSSNQMSFPMQSFGFYGHQPHTQNPQGQIHGGGHPYFNHGLAPMVDQMTNNYYDFSSQQNYQHDYTMYAPIQNRTSSNESSESWNTTTSSLMPTSSESRAPSALTVDEFPGINAGFVFPKYEF
The following text describes a protein:
Function:
Required during meiosis. Regulates the transition from the extended G2 phase to the onset of the first meiotic division.
Sequence:
MASKRLMLDVEEEDDESGACGQENFDPHDADMEYQAKRRKSAVQETPLQWMLKRHIPASTTVLSPITELSQNMNGARLDGTPKSTQRIPANRTLNNFNSLSSRTLGSFSSSCSSYESGNSLDDEYMDMFEMESAENHNLELPDDLEVLLSGQLKSESNLEEMSNKKGSLRRCLSMYPSEQPEEAVQEPDQETNMPMKKMQRKTLSMNDAEIMRALGDEPELIGDLSKPCTLPCLATGIRHRDLKTISSDTLARLIQGEFDEQLGSQGGYEIIDCRYPYEFLGGHIRGAKNLYTRGQIQEAFPTLTSNQENRRIYVFHCEFSSERGPKLLRYLRSNDRSQHTHNYPALDYPELYILHNGYKEFFGLYSQLCQPSQYVPMLAPAHNDEFRYFRAKTKSWQCGEGGDSGIGGGGSRGLRKSRSRLLYAE
The following text describes a protein:
Function:
Strong inhibitor of ribonucleotide reductase (RNR1) and is involved in regulating dNTP production.
Miscellaneous:
MISCELLANEOUS: Present with 18800 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MQNSQDYFYAQNRCQQQQAPSTLRTVTMAEFRRVPLPPMAEVPMLSTQNSMGSSASASASSLEMWEKDLEERLNSIDHDMNNNKFGSGELKSMFNQGKVEEMDF
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAVMDLSSPWALTKQDSACFHLRNAEEERMIAVFLTTWLQEPMTFKDVAVEFTQEEWMMLDSAQRSLYRDVMLENYRNLTSVEYQLYRLTVISPLDQEEIRNMKKRIPQAICPDQKIQPKTKESTVQKILWEEPSNAVKMIKLTMHNWSSTLREDWECHKIRKQHKIPGGHWRQMIYAPKKTVPQELFRDYHELEENSKLGSKLIFSQSIFTSKHCQKCYSEIGCLKHNSIINNYVKNSISEKLYESHECDTTLWHFQRNQTVQKEYTYSKHGMHFTHNMFPVPNNLHMAQNACECNKDETLCHQSSLKKQGQTHTEKKHECNQCGKAFKRISNLTLYKKSHMGEKQYECKECGKVFNDSSTLRRHVRTHTGEKPYECNQCGKAFSQKTSLKAHMRTHTGEKPYECNQCGKSFGTSSYLIVHKRIHTGEKLYECSECGKAFNTSSHLKVHKKIHTGENVYECSDCGKVFSGVSSLRMHIRTHTGEKPYECKECRKAFSVSSSLRRHVRIHTGEKPYECIQCGKAFSQSSSLIIHKRIHTERETL
The following text describes a protein:
Function:
Rapidly hydrolyzes choline released into the synapse.
Subcellular Localization:
Synapse. Secreted. Cell membrane; Peripheral membrane protein.
Sequence:
MKPKLVFLPFLIFITVFIEESEAVHPVVLETKLGDIRGNEFFFLSKKIRTFFGVPFAEPPVEEFRFRKPREKKQWKKLFDATKPANACFQTRDNYNTSFWGSEMWNANTQISEDCLYLNIWAPADAYNLTVMVWFFGGGFYSGSPSLSIYDGRALAATQHVIVVNINYRLGPFGFLYLDHPDAPGNMGLLDQQLALHWIRQNIVSFGGNPDKVSVFGQSAGAASIVAHLIAPGSRGLFKNAILQSGSLENTWAINSPFRAKQKSEKLLELVGCNKTTVENSMSCLRLVSPEQLSLSTWNISLTYLEFPFVIVSRDKHFFGHLDARAALREGDFNRDVNLMIGMNKDEGNYWNIYQLPQFFDKAEPPELTRHQFDNLIDSTFSIQPDIIRSAAKYIYSDPNCTDHGRKTRFYAGQMNQIVGDYFFSCDSLWLADQFFLFLQICSTPNGSLKNPPKVFVYYFTQSSSANPWPKWTGAMHGYEIEYVFGVPLSYSKIYKRREQIFSRKIMQFWASFAKNGTPRLRVLKNSEHWPEFNEHNNYRWMQLRSGSNIRPIKRRKETECQFWRRVKDTEYTAYLTQEYSSSCHINSYRILLFIPFFFIFSAF
The following text describes a protein:
Function:
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Hemokinin induces plasma extravasation, mast cell degranulation, muscle contraction, salivary secretion and scratching behavior. Increases sperm motility. Induces potent analgesic effects and may play a role in pain modulation. Promotes survival of bone marrow B lineage cells and of cultured LPS-stimulated pre-B cells and may act as an autocrine factor required for B-cell survival and proliferation. Lowers systemic arterial pressure following intravenous injection. Induces interferon-gamma production and may play a role in the inflammatory response. Shows potent affinity and specificity for the NK-1 receptor.
Subcellular Localization:
Secreted.
Sequence:
MLPLLALLLLIGPSVCTTAGDREELAFGAEAESWVTVNLKGIPVPSIELKLQELKRSRTRQFYGLMGKRVGGYQLGRIVQDLLGTRGLSIEGTCRQAASQQRARPGAVTRESLQSREEDEAPLTTSNV
The following text describes a protein:
Function:
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
Miscellaneous:
MISCELLANEOUS: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
Subcellular Localization:
Cytoplasm.
Sequence:
MTDITLPPGDGSIQRVEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMLDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYCVSGNSLVRLLFGKSIRIGDIVTGAQFNSDNPIDLKVLDRHGNPVVADYLFHSGEHQTYTVRTTEGYEITGTSNHPLLCLVNVGGIPTLLWKLIGEIRSGDYVVLQRIPPVEFGPADWYSTMEALLFGAFISGGFVFQDHAGFNSLDRDYFTMVVNAYDTVVGGLRCISSRITVSGSTLLELDVYNLIEFKKTRLSGLCGQRSADKLVPDWLWHSPSTVKRAFLQALFEGEGFSSILSRNIIEISYSTLSERLAADVQQMLLEFGVVSERYCHTVNEYKVVIANRAQVEMFFTQVGFGVTKQAKLIRDVVSMSPCVGMDINCVPGLATFIRKHCDNRWVEEDSFNQHNVDCVQHWHHHSAEIVGHIADPDIRAIVTDLTDGRFYYARVASVTDTGIQPVFSLHVDTEDHSFLTNGFISHNTEARLTPLAMEMLREIDEETVDFISNYDGRVQEPMVLPSRFPNLLANGSGGIAVGMATNIPPHNLYELADAVFWCLENHDADEETMLVAVMERVKGPDFPTAGLIVGSQGIADAYKTGRGSIRIRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRTGRLAGISNVEDQGSDRVGVRIVIEIKRDAVAKVVLNNLYKHTQLQTSFGANMLSIVDGVPRTLRLDQMICYYVEHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVITLIRASQTVDIARVGVVELLDIDDIQAQAILDMQLRRLAALERQRIIDDLAKIEVEIADLGDILAKPERRRGIIRNELTEIAEKYGDDRRTRIIAVDGDVNDEDLIAREEVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVRHFFVCSTHDWILFFTTQGRVYRAKAYELPEASRTARGQHVANLLAFQPEERIAQVIQIRSYEDAPYLVLATRAGLVKKSKLTDFDSNRSGGIVAINLRDNDELVGAVLCAADGDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNADDRLLSLNVVREDTYLLVATSGGYAKRTSIEEYPMQGRGGKGVLTVMYDRRRGSLVGAIVVDEDSELYAITSGGGVIRTTARQVRQAGRQTKGVRLMNLGEGDTLLAIARNAEESADGVSVKVMISRSRVLSFFGSDSNTSPDRT
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
KMSFVKAQKARQKPHRERGQVSGREGLGLLEKKKDYKLRARSYKEKEKQLKALRKIAQSKNPDEFYFGMIKTKLTDGEHVKDFIREEQTATPAQKMLMETQDLNYVKWKLQIEKKKIEKLENRIHFVDGTTNKHIRFIDSNEEIPLEKPKTNTVRISLINEWASMIKEGTASKRLVREIEQRKTRVKELQAVVDKLTIQKILSTDKAVKDRDLVKREDASSAAIYKWKPLRKR
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MQSKSGRGNEEEANHHHADQQQQQPIMYPEPWWKTNAFGVIPQERPSSGIPSKSSSLDCPNGSESNDVHSASEDGGGPGNGENDAAWKDSQAVTSSPSVDQHGMEGSDPAHVAASMHGMHNQQPVQPPELVGHYMACVPPNPYQDPYYAGMMGAYGHQPLGFRPYLGMPRERTALPLDITQEPVYVNAKQYEGILRRRKARAKAELERKVINRKPYLHESRHKHAMRRARASGGRFAKKTEAEAAAEDAAAAGRGREKGSATNSSGSEPVETDSNDTLNSSGAP
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
Subcellular Localization:
Peroxisome membrane.
Sequence:
MPDPTSPDRVQLIQNAILFLNDPKTQNSSLTSRVQFLESKGLTEKEIEQAIREAGSGYGSSAGSGKQGAVGEGEAEGERTGPSSVYERPPERPRVPAPNYGYGYTYAPPEPPKRDWRDLFIMAMVSGGVVYGLTALARKYLLPHLRPPSTTAFQSTSSELTSKYDEATRLLNELTEETTKVQVSIEEDREKVNQVVEEVEGAVKGLKAGEERWRDEMRDMRGEVESLKELVPRMIEKHMQSQSSALADLQSEIRSLKTLLASRSQLPPTGSAAGSGSGSRSDVGSPAPTPTAAAANALLGPRAGGKAGIPAWQMAPPAPPPTNTAHTSSDSTSTSGSGSGEDTSETGKGNDKEV
The following text describes a protein:
Function:
Required to repress ESX-1-mediated secretion under low ATP conditions. This function requires the ATP-binding motif.
Sequence:
MAADYDKLFRPHEGMEAPDDMAAQPFFDPSASFPPAPASANLPKPNGQTPPPTSDDLSERFVSAPPPPPPPPPPPPPTPMPIAAGEPPSPEPAASKPPTPPMPIAGPEPAPPKPPTPPMPIAGPEPAPPKPPTPPMPIAGPAPTPTESQLAPPRPPTPQTPTGAPQQPESPAPHVPSHGPHQPRRTAPAPPWAKMPIGEPPPAPSRPSASPAEPPTRPAPQHSRRARRGHRYRTDTERNVGKVATGPSIQARLRAEEASGAQLAPGTEPSPAPLGQPRSYLAPPTRPAPTEPPPSPSPQRNSGRRAERRVHPDLAAQHAAAQPDSITAATTGGRRRKRAAPDLDATQKSLRPAAKGPKVKKVKPQKPKATKPPKVVSQRGWRHWVHALTRINLGLSPDEKYELDLHARVRRNPRGSYQIAVVGLKGGAGKTTLTAALGSTLAQVRADRILALDADPGAGNLADRVGRQSGATIADVLAEKELSHYNDIRAHTSVNAVNLEVLPAPEYSSAQRALSDADWHFIADPASRFYNLVLADCGAGFFDPLTRGVLSTVSGVVVVASVSIDGAQQASVALDWLRNNGYQDLASRACVVINHIMPGEPNVAVKDLVRHFEQQVQPGRVVVMPWDRHIAAGTEISLDLLDPIYKRKVLELAAALSDDFERAGRR
The following text describes a protein:
Function:
Confers high-level resistance to glyphosate when overexpressed. Overexpression has no effect on intracellular arabinose concentrations.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPEPVAEPALNGLRLNLRIVSIVMFNFASYLTIGLPLAVLPGYVHDVMGFSAFWAGLVISLQYFATLLSRPHAGRYADSLGPKKIVVFGLCGCFLSGLGYLTAGLTASLPVISLLLLCLGRVILGIGQSFAGTGSTLWGVGVVGSLHIGRVISWNGIVTYGAMAMGAPLGVVFYHWGGLQALALIIMGVALVAILLAIPRPTVKASKGKPLPFRAVLGRVWLYGMALALASAGFGVIATFITLFYDAKGWDGAAFALTLFSCAFVGTRLLFPNGINRIGGLNVAMICFSVEIIGLLLVGVATMPWMAKIGVLLAGAGFSLVFPALGVVAVKAVPQQNQGAALATYTVFMDLSLGVTGPLAGLVMSWAGVPVIYLAAAGLVAIALLLTWRLKKRPPEHVPEAASSS
The following text describes a protein:
Function:
Plays a role in controlling food intake and regulating body size.
Subcellular Localization:
Secreted.
Sequence:
MYRINLTTFTLLLVLAVGSLMSESLHPSDGAINDLYEYLLQREYAAPVSYADHQIKRKAVRSPSLRLRFGRRSDPSVPLRPEEDELIDQKAIRAPQLRLRFGRNDPLWTSFNENALLEENFEKRAPSQRLRWGRSNLFGNLVNQFQQDDVMQQKTIRAPQLRLRFGRTDPSWAMYNEHQLTTGQQAQPANEASEKRAPTQRLRWGRSDPALAKDSSEDKALDVEESENTNADDK
The following text describes a protein:
Function:
Involved in trafficking and recycling of synaptic vesicles.
Subcellular Localization:
Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Early endosome. Golgi apparatus, trans-Golgi network. Late endosome. Membrane; Multi-pass membrane protein. Recycling endosome.
Sequence:
MAKDVHRVANAHDARLKTADGNKFASFAKEDAARAAAPDLDFRRKTFPVRTGLAAASLFALGSILIYVSTLIGLDEEKRGLSFLILGLIAFIPGSYATYQLYGAWQGWKGYNYDQIPSYDD
The following text describes a protein:
Function:
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAPVSLSLRKKSLLNQSTEVMASASTGSRVSCGRDMNCVPEIAATLAAVAKLGFDFLCMPLFHPRFAREFELEPAKSRPGAQTRSDLLLCGRDWGTLIVGKLSPWICADSEIETERRNSEEALTQELNFSAYLGLPVFMIPLTGPHNANLARLLLSHIHTGHHTSNFWIRVPLMAAEDTREDLIENEPFSCPDETSVDEKTWNWWNTFRTLCDYNKRICLAIDIGADMPSDAVIDKWMGEPIKAAILPTSLFLTNKKGFPVLSKAHQRVIFRLFKLEAQFIFTGTSRHTEKDFRSYLQYLEYLNQNRPAPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAVYKCLLDRVPEEQKDTNVQVLMVLGAGRGPLVNASLRAASQADRKLKVYAVEKNPNAVITLENWRFEEWGDRVTVVSSDMREWEAPEKADIIVSELLGSFGDNELSPECLDGAQHFLKDDGVSIPCSYTSFLAPLSSSKLYNEVRGCRERDKSPECHFETPYVVRLHNFHELADPKPCFTFTHPKKDMNNNRYQCLRFSVGCNSVLHGFAGYFETTLYKDVTLSIKPETHSPGMFSWFPILFPLKQPISIARDDEIAVRFWRCNNGKKVWYEWAVTEPTCSAIHNPAGRSYTIGL
The following text describes a protein:
Function:
Member of the two-component regulatory system TrcS/TrcR. Phosphorylates TrcR. The TrcR-TrcS regulatory system may act as a transition regulatory system involved in adapting to an intracellular environment and transitioning from latency to reactivation.
Miscellaneous:
MISCELLANEOUS: Overexpression in M.smegmatis mtrB background reverses the mtrB mutant phenotype including the expression of the MtrA-regulon. TrcS interacts with MtrA and is capable of phosphorylating MtrA in vitro. These results suggest that under certain specific conditions in vivo, TrcS could phosphorylate MtrA, independent of MtrB.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIPDRNTRSRKAPCWRPRSLRQQLLLGVLAVVTVVLVAVGVVSVLSLSGYVTAMNDAELVESLHALNHSYTRYRDSAQTSTPTGNLPMSQAVLEFTGQTPGNLIAVLHDGVVIGSAVFSEDGARPAPPDVIRAIEAQVWDGGPPRVESLGSLGAYQVDSSAAGADRLFVGVSLSLANQIIARKKVTTVALVGAALVVTAALTVWVVGYALRPLRRVAATAAEVATMPLTDDDHQISVRVRPGDTDPDNEVGIVGHTLNRLLDNVDGALAHRVDSDLRMRQFITDASHELRTPLAAIQGYAELTRQDSSDLPPTTEYALARIESEARRMTLLVDELLLLSRLSEGEDLETEDLDLTDLVINAVNDAAVAAPTHRWVKNLPDEPVWVNGDHARLHQLVSNLLTNAWVHTQPGVTVTIGITCHRTGPNAPCVELSVTDDGPDIDPEILPHLFDRFVRASKSRSNGSGHGLGLAIVSSIVKAHRGSVTAESGNGQTVFRVRLPMIEQQIATTA
The following text describes a protein:
Function:
Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MKQSLLFHFIDCENSMVQGDEKCWYCGTMEKTLALESRDLGLNLVSDTCYFCDFGIASSLDVLESPGSIQVARGQTAVLPCTFTTSAALINLNVIWMVIPLSNANQPEQVILYQAGQMSDGAPRFHGRVGFTGTMPATNVSIFINNTQLMDTGTYQCLVNNRPDTGGRNIGVTGLTVLVPPSVPLCRIQGSQDIGSDVILICSSEEGIPRPTYLWEKLDNIPRLPPSATQDQIHGTVTLRNISSVSSGLYQCVASNAIGTSTCLLDLQVISPQPRSIGVIAGVVSSAAIVVILCLILMLVAFFYWRSRNKEEEEEEIPNEIREDDLPPKCTSSAKAYHAEVSSSENNTLTSSNTYNSRYWNNNPKVHHTMESYGHPGDLHQSFSLHSGSANIPSIYANGSHLVPPSVKTLVVTANKAPSPQATSRSNGSISRKPRSQHTHSYAVSQTTLERMGAVPVMVPAQSRAGSLV
The following text describes a protein:
Function:
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
Subcellular Localization:
Cytoplasm.
Sequence:
MGYLFTSESVSEGHPDKVADQISDAVLDKLLAYDPSSKVACETLVTTGQVVLAGEVKTKAYVDLQLIAREVIKKIGYTKGEYMFESNSCGVLSAIHEQSPDINRGVERQDPMEQGAGDQGMMFGYATNETENYMPLSLDLAHRILQVLADIRREEKVMTYLRPDAKSQVTIEYDDNGTPVRIDTIVVSTQHDDFIQPADDSAEAQLKADEEMLSIIRRDVIEILMPRVIASIHHDKVLALFNDQIVYHVNPTGKFVIGGPHGDTGLTGRKIIVDTYGGKGAHGGGAFSGKDPSKVDRSAAYAARHIAKNMVAAGVADEMLVQVSYAIGVARPINIFVDTYGRSHVNMTDGEIARVIDQLFDLRPKAIEERLKLRNPIYQETAAYGHMGREPQVVSKTFFSRYEGNKTVEVELFTWEKLDYVDKIKAAFGL
The following text describes a protein:
Function:
Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.
Subcellular Localization:
Cell membrane. Cytoplasm. Endomembrane system; Peripheral membrane protein.
Sequence:
MSTSDDIPTANSDSFWEVDCYKRTVKRAEDGFTACNDLIKMIQERAEIEKEYAKRLKMWSKRWNEYFDKCSEYGSTKLTLKESLEESDKLASVHLTIRERLNNEISINIKDWRNENYKKQMMVGGCKEAKSFEEDFKRAQKPWSKKLSKVIKCKKDYHNACKLERTAINQETNAKNNTEISLDQLRKLQEKVDRCKKDVIIMKEKYEQALIEINAYNGRYIEDMAEVFQKTQDFEKVRLNFIKGILFKLQSCLDLTKFTEIPIIYNNYTQSVNKLEPEKDLKWWSENHGVEMAMTWPTFEEYITEFHSITSKPTKSADGGVMLTYVQKNDSDPVSSTTSSMTSSSISAMNKNIWQANEKTSASADFSNTNVVKNGVKVKALYDYVSGEKDEISFKAGEVFLKLKNRDEQGWCTGLKDGKVGLYPDHYVEPVIDTLF
The following text describes a protein:
Function:
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Sequence:
MSNFAVSLPEVIAVLPAAGIGSRMLVDCPKQYLTVGGKTIIEHAIFSLLHHPRIQRVIVVIHPQDTQFSRLSVAQDPRISTVYGGDQRANSVMAGLQLAGQAEWVLVHDAARPCLHLDDLSRLLSITECSQVGGILAAPVRDTMKRAEPGIQAIAHTVDRQDLWHALTPQLFPLELLKLCLSRALREGVAVTDEASALEHCGYHPILVTGRSDNIKVTRPEDLALAEFYLTQRQSLNNDSL
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC); Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex. Nucleus membrane.
Sequence:
NQSDKKIVDNLYDKDGEIRQAQLVIDWLENNAGDELVNFHEKVEYFSRQVCWENTLHDMLFPKLGSPTVVKEMDPDAPIRSGLPLMDLDEEDDARLLKHIFRLVRAGQVTKAQEVCIRCGQAWRAATLEGWKMWHDENLESGKNLFVMIGNPNRDIWKSSCWQLSEQAKFNRYERALYGCLSGNLEKVIPVCESWDDYLWAYYKCFIDERVEQVVIRYSSVIRFVLNYINLCIYLINCSLNPEKIFDALDNNSNESVRHHASCYYQTAQKHVILDDVNDFLAKSISWIGSNERSSDVLRFLTHLALFLRGIGLNLNDEVCDNVIELYVQVSLLIKKIDAIEWMIFNPSQRIEAIKHANAVMRYFIACRKHSAAREVYTKVPSGSIDLVYKQWQTRAGESNLPADDDNAIREFLCIQAYLDAHEAFTEWFQQYYHGKPEEPHVTQISRQQSIAKIAYEEKTKAYRLELERWERNIEIYSKDAIEKLYNVLLFVDGGWMVDARTDAVVDESRKHQLEVLRQLCLPLICFLLQTVLQATQQYDQSLRLAVVIASEQYKLYETFRPDELQQFLRLLCESAKEILSQPQLSDENNDK
The following text describes a protein:
Function:
Involved in the biosynthesis of the naphthoic acid (NA) moiety in the chromophore of the enedyine antitumor antibiotic neocarzinostatin (NCS). Catalyzes the hydroxylation at C-7 position of 2-hydroxy-5-methyl-1-naphthoate to yield 2,7-dihydroxy-5-methyl-1-naphthoate.
Sequence:
MCPYRLDPEGADTHGETARLREQGPIARVELQDGVLAWSVHDYAVAKQIMADERFSKNPRKNWPAYINGEISNGWPLITWVAMDTMATQDGADHARLRKLLLKAFTERRVESMRPHIEKTVKELLDNMAAKADDEIVDIKEMFHAELPTRLMCDLFGVPEERRAEVLAGGHKNIDTRISSEAAEANLGQWQEAISDLVEYKRHHPGDDLTSALIEARDEGSRLSDSELIGTLHLLLGAGSETLVNALAHSSLALLVDADLRKKVTSGEIPWVNVWEETLRVESPVAHLPFRYATEDFEIGGVKISKGDPLLVDFAGIGRDPAVHSDAPDEFDALRPDKTHLSFGHGVHYCLGARLAKHAWMIGIPALFERFPDMELAVRRDELKGQGSFVVNGHASLPVHLKGRAAALAR
The following text describes a protein:
Function:
Secreted protein required for efficient export of lipids such as acetylated sterols. Acts in detoxification of hydrophobic compounds.
Subcellular Localization:
Secreted.
Domain:
The SCP domain is necessary and sufficient for lipid export and sterol-binding.
Sequence:
MKFSKVSLLAASASVALSAPVAVTVTQHVHQAATVVVQGIVRVENGQTLTTFITKGTQTASASPVATTSAPIVVANAQVDSIATSVIQESAVVAESATFEESSTETSEAFSTATATIQAVQTSASATQDDVTTTLTSSTQPTSTTTPTTTTTSPTTTTSPTTTASPTTTASPTTATTTQSTASSTQSSSSDFSTSMVNEHNTKRALHKDTGSLTWSDTLATYAQNYADSYDCSGNLVHSGGPYGENLALGYGTTGSVDAWYNEITSYDYSNPGFSESAGHFTQVVWKGTSEVGCGLKSCGGEWGDYIICSYKAAGNVIGEFADNVMPLA
The following text describes a protein:
Function:
Has a role in transcriptional regulation. Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth. Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate. Required specifically for the microtubule-based basal transport of lipid droplets. Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye. Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAQQQQQQQQQQHLQHPHQNTNSNNQLQQQQQQLQLQLQLQLQEQQEQQQQQLQLQQYNNNFYSQNYNMEEYERRKRREREKIERQQGIQIDDRETALFSEPRRLTEGDAEITAALGEFGDARVYINQSTVGISRHAPGAGNPRLQAPPPPKTLGHSHSPSSSSAAGSGSGSALPGQSQSQQQQQKQHYQQQQQQQRPPGYLKQADNKPPYNGRGGYPGQPMKNDIPSSSGMAPPRGPPRSGSGSISNSNSNSSSATNNATGGAAGTTPLGPPLSTQMPNGREKSFLGPPAPALHNGAGLFVPPAASKRPGGGSGAGLQPPPPEKDITKMISEMTNSFRVTAPLTSIAATPHAPTRENYNLNGPNTNKYAFGPIGSPPIGSQPSSLMAPLFAPIAPIASPITSLLTTPPHASQGSLGGASPVAPLQQLPPTPPKAAAALSPTAAAKPLKTEKNHTLEKQDSCLENDLELSESEDEQRKKESRSAGNSSNSSESDSSESGSESSSKGDHQQQHHHHNHHHQQQQQQLQQQQQQQLLQQKQQHQQILQQQQRQLTANGSKKKYSHSIIAGGGSTISGLLTSSGFGSGGAGNGGCSTASSGGGGGGSGSGGGSGSSSGIGTMSSGSSSNKTPSPTESNKWTLSRFFPKPANQTSSESVSPGNVSMKVPGILPGGAQIIPESIEVTTAIVKNEKIHDDHMDMDEVEEEDEDEEQLQQQQQLRYGAGLSVTPVAVAVKKEALDGVGEMGGLPAIPKNQIKREAEALHSAARLSDSGTSGSGSTSSSSSSSDSAPGEVVPMPGPGETLQLPGVPAAITTVMRVHPTLMQKAPPNSVTLTPILPLPASPKQRQKKPRKKKPATSAPILDSSDDDDPPAAKHALELSAAAAAAAQAQATATVPPLAVKKGRGRPRKQQQSGGSGNLSSASAGSSSQTKGPTLTAAKKPLVKGPAMANSRKRDHSSQSSSNGNTPTKKLAMGTGTGTGTAMAVPMTVIPSGPANASAVAAASSSSDEDSSSSTGSTGSKSSSSSSSSDDTETTQNTKCRIVKLNKTGAVPPLARLGAVASAGAGAGAGASGSSSPSSSSSEPEDHLAMSTVSALPMAQQLMQPYKPRAVSQHSQQLSSSECSSSSGSSTSGDEDEAKREKERERKRKSDKNKISTLTRIFNPKEGGAKKQGQVVIMDQSEEQQQVKVGDSSSQPVPVQNAAIAKLRMTPTQQQQQLGAGLASPARTTTPHLTSLICKIDLSKLSRERIMRLKKLTPSQQNGHLTPKDLVTIQTQGPSQPVQGHLLPAKVKHEHPHPVKPEPELDAGYESKFKPGNVKQEFQLKQERDRERERERDRDRERERERERDREREREQPTGGRRRKRSSSSSSSPYKEKKRKKEKSDHLQISKDQLLPVPVLLPSNNHERISCHERLSFDKLQLLHEDAAAVAAAAAAVSAPNGSPSKKLLVMSPLPPPPTAVVVPPAVVAPSTCSEAVQTTPPSAAATATAATSTTGTSTAPPAPVTRLIYRSYFDREEEPHSDDHRKNNQFLVEAVNRKHAADSERDSFNQVTLYLEAVVYFLLTADSMERSSSEQATWTIYKDTLSLIKFISSKFRPYQQSTNGQHETHNKVAILSLRCQSLISLKLYKLRRTNCRTVINSLTEFFRTGRGDIVNGNTPSSISPSNSVGSQGSGSNTPPGKIVPQEIHTQLSKQNEYLTYVNSAHELWDQADRLVRTGNHIDFFRELDHENGPLTLHSTMPEVFRYVQAGLKTLRDAVSHPTQQTLHQSH
The following text describes a protein:
Function:
Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress.
Sequence:
MWAHHVKWRMRGTQLYVRHTTLPIVLIYWSRLLQIPPSVMQSLVSIFTYITKCKGSRRQDTYKDLSVTLLVPCYSNTTRKILQFPSWFAEKHNFAKPNDSRALHLMTKCAQTVMKELEDIVIAYGQSDEYSFVFKRKSNWFKRRASKFMTHVASQFASSFVFYWRDYFEDQPLLYPPGFDGRVIVYPSNQTLKDYLSWRQADCHINNLYNTVFWALVQQSGLTPAQAQERLQGTLAADKNEILFSEFNINYNNEPLMYRKGTVLIWQKVGEVTTKEVKLPEEMQGKKMAVTRTRTKPVPLYCDIIGDAFWKEHPEILDEDS
The following text describes a protein:
Function:
Required for proper cell morphogenesis and cell separation after mitosis. Functions in the RAM (regulation of ACE2 activity and cellular morphogenesis) signaling network and is required for proper ACE2 localization and CBK1 kinase activity.
Miscellaneous:
MISCELLANEOUS: Present with 892 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Note=Localizes to cortical sites of growth during both budding and mating pheromone response. Localized prominently to incipient bud sites and small buds and weakly to the cortex and bud necks of large budded cells. Also localized to the growing tips of mating projections.
Sequence:
MVATSSKRTLDPKEEHLPADKTSTNSSNTIISELATQEKSSSSGTTLKLIALNIKSISDEDVGYIQNVERLSLRKNHLTSLPASFKRLSRLQYLDLHNNNFKEIPYILTQCPQLEILDLSSNEIEALPDEISSFWQDNIRVLSLKDNNVTSIRNLKSITKLNKLSILDLEDNKIPKEELDQVQSYTPFHTGIPKEEYWAIAISRYLKDHPNLPTPEPKISRAAKRMGFINTNLSNGAMNENNIISLAPSANTTISASTAMVSSNQTSATSFSGTVNAESEQSGAVNGTELYNHTKYNDYFKRLSILPEESMSNGHQKISHAELVVSCRKLLFSFTECQQAIRKIASFCKEKAVAVNVVSLLYSVRSHTDNLVEVLQQTENEDESHDQALIKLCLTIITNFKQIITLLRKNFEIFFKEDDLCFIRMFYMTLMCAYMEMYNAWSFIKEDDQVSGSASKAPKKHSFSRHETSSSSITSGGGPAASTTSTHCSGNIKLLPKTRSTRTPSASALLSNSNILTGDTTAVPLLSPNLNGAHTHGPILGHQNAISNGSSQTNMNEVKTTSDTIPRQQLLQHNKSISDSKKESQAHEPKQHPVMTSSIINASNSNNVSNVNITPPPMNGGGAANSSANVVETNIDIQLYQTLSTVVKMVSVVYNQLTSEISKIAIASTMGKQILTDSLAPKIRDLTETCRQAMDLSKQLNERLNVLIPNDSNSEKYLTSLEKLKTWEIMNSFLKVIISILANTKIVMSDVPNLNELRPNLANLAKITKDVTVILDLSSYKAVSVSANSPE