lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the PEX1-PEX6 AAA ATPase complex involved in peroxisome biosynthesis. The complex acts as a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-6', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5.
Subcellular Localization:
Membrane.
Sequence:
MDNHKARISYKTLKSNLVNLPSSLTNLLFTANIQVQDVIIEMVTTTSNGNKKNSTTTKHYAGWSGMSSSDISNLEIDPVFAQSLNLIDKTPIIVNLKLGNYESTNINLEPLTSSDWELVELHAQSIEDKLLSQTRCVALNQVLVVYPSATTSAKLLVTDLGSTDHTFAKISPYCEIAIAPKVREKEQKNNKTASSSKSIASSKSTKRTTSSSSEDYSDLPSVLKRGISLPHKLYNVNEAVAGYFVYVDIDDELPQGFNSEYVAVSVIPGPNDKTSTKALQATEDDNNNNNSNNNNKNLKENKRIIAKLVDYKSGPSGNIGLSRNLAIALNIENQIGNIISLKPAIKNLPKRPTTFTIHPYIIHTKKKEITISSNKKENKLAQQLTEIMYPGIASIPITNFTKIPIIANILPYGGLLRFRKNDEYNAWIKPYNLDSKKPIKFEIGDEILRPSSFIEQEIDKPTTNDTEEQEAIGLDNTVEDIVDSFITSDNTGTLVYGNSGSGKTLLLKLVAQQLNQQHGYFTKYISCDTIMNENFQNLSKNHFFKWIQTCAWNKPSVLILDNIDKLMSVEMENMDATKSNQLTEFFISNLTKIHHQLNSNLSILLSANSKDNINKLLLGSHLIENFHHLNPPDKSLRFEILDKYLTNKLGLKIKVDLMDLVSETEGYLPNDLKILSDRIYHEVLFNSTETETETETEATTNAAVTSEHIEKALAGYTPSNLRGVKLQKSSINWSDIGGLKEAKNILLETLEWPTKYAPIFANCPLRLRSGILLYGYPGCGKTLLASAIAGQCGLNFISIKGPEILNKYIGASEQSVRELFERAQAAKPCILFFDEFDSIAPKRGHDSTGVTDRVVNQMLTQMDGAEGLDGVYVLAATSRPDLIDSALLRPGRLDKSVICDMPNYEDRLDILQSITTKMDLSDDVNLHEIAEKTTGFSGADMQGLGYNAYLKAVHVTLEELSQREQDEANNEDGNNNFEKNSIEFFQVGNSEKKLKTNEKIQLLHQIQQFMNPNKDNSDSERKAGQDAMNKSKVLITHENFLESLKETKPSISHSEKIKLTKIYKEFVNDRDGNMPDGTPSNEIGGRTTLM
The following text describes a protein:
Function:
Probable transcription factor that regulates the expression of dopamine receptors dop-1, dop-2 and dop-3 and thus dopamine-dependent behaviors. May act redundantly with hlh-31 and hlh-32 to regulate ventral CEPsh glia functions. May play a role in chemotactic responses in larvae.
Subcellular Localization:
Nucleus.
Sequence:
MEKIGIDTAFAEPGVRLSINLRERCRMHDLNEALDDLRAVIPYAHGGSVRKLSKIATLLLAKNHIIMQAKAIEELSILVSQLKRKSENLENLNKSLKPDAN
The following text describes a protein:
Function:
Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell surface. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane. Melanosome. Membrane; Multi-pass membrane protein. Secreted.
Sequence:
SGIAILAVGIWVITSRSQYNSLLSNDNYVTVPGLMIAAGCLVIIVCVVGCVAVIKENRFILVSYLIMLVLIFILEIATGVVAVIYRSEVSKISYELEVGIRGKMNRYGFTDAVTKAIDDLQKEFKCCGDRGMDSWNNTSWKQSEISGNNSVPDSCCKSPSPGCGIRLHPNNIQEFGCISKLEKFFLDNLAILVGVAFGLAFSQV
The following text describes a protein:
Function:
May function as a co-chaperone.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVERKKSLLLTYIIWFKLGWLGLHHFYLGRDIQAFVWWSTFGGVFGLGWLRDLWRIPEYVEDANEDHYYIEELKRKIKLRKEPPFSTTRFAGQMLVGYFYGILTRLAIPESAPKWTPALWVPLAVASGIYLVGNIGRERGDFKYALIGCLVSYASITFINGDEAGNIRVQVLALGGLIMCALWGSFIYFNAEVTTEDGETIKLRDAVNHFFNSPVWLEFKDVLWQLYDEGQKNGWQNLYDDFVKALDPRGEKNSYRVLGLTEDATQEEIKKRYKKLAMKWHPDRHRDNKEEAQKHFMEIQEAYEILSKLKTKRASKNTRTDSDYNASSREKTEF
The following text describes a protein:
Function:
Lignin degradation and detoxification of lignin-derived products (By similarity). Multicopper oxidase that catalyzes the oxidation of a variety of substrates, including phenolic and non-phenolic compounds. Has highest activity towards 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), also active towards hydroquinone, phenol, gallic acid, catechol, guaiacol, levodopa, 2,6-dimethoxyphenol (2,6-DMP), tyrosine, ferulic acid and veratryl alcohol.
Subcellular Localization:
Secreted.
Sequence:
FQLNVIANNNNHTMLTQTTIHCHGFFQGTNSADGHAFVNCCPIASGHSFLYDFSHPDQHGTFCYHSHLSTQYCCGLRGHFVVYDPSDPHCGLYDVDHDSTVITLSDWYHVAAKLGHSFCLGADSTLINGSGRSTGDCAASLTVISVTQGKRYRFHLVSLSCDPNHTFSIDGHDMSVIEVDSIASQHVTVDSIQIFAGQRYSFVLTANQSINNYWIRANPSFGNIGFHDGINSAILRY
The following text describes a protein:
Function:
Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway. Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling. May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm.
Sequence:
MKSAKPQVNHSQHGESQRALSPLQSTLSSAASPSQAYETYIENGLICLKHKIRNIEKKKLKLEDYKDRLKSGEHLNPDQLEAVEKYEEVLHNLEFAKELQKTFSGLSLDLLKAQKKAQRREHMLKLEAEKKKLRTILQVQYVLQNLTQEHVQKDFKGGLNGAVYLPSKELDYLIKFSKLTCPERNESLSVEDQMEQSSLYFWDLLEGSEKAVVGTTYKHLKDLLSKLLNSGYFESIPVPKNAKEKEVPLEEEMLIQSEKKTQLSKTESVKESESLMEFAQPEIQPQEFLNRRYMTEVDYSNKQGEEQPWEADYARKPNLPKRWDMLTEPDGQEKKQESFKSWEASGKHQEVSKPAVSLEQRKQDTSKLRSTLPEEQKKQEISKSKPSPSQWKQDTPKSKAGYVQEEQKKQETPKLWPVQLQKEQDPKKQTPKSWTPSMQSEQNTTKSWTTPMCEEQDSKQPETPKSWENNVESQKHSLTSQSQISPKSWGVATASLIPNDQLLPRKLNTEPKDVPKPVHQPVGSSSTLPKDPVLRKEKLQDLMTQIQGTCNFMQESVLDFDKPSSAIPTSQPPSATPGSPVASKEQNLSSQSDFLQEPLQATSSPVTCSSNACLVTTDQASSGSETEFMTSETPEAAIPPGKQPSSLASPNPPMAKGSEQGFQSPPASSSSVTINTAPFQAMQTVFNVNAPLPPRKEQEIKESPYSPGYNQSFTTASTQTPPQCQLPSIHVEQTVHSQETAQTNVFPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYKGFDTYRGLPSISNGNYSQLQFQAREYSGAPYSQRDNFQQCYKRGGTSGGPRANSRAGWSDSSQVSSPERDNETFNSGDSGQGDSRSMTPVDVPVTNPAATILPVHVYPLPQQMRVAFSAARTSNLAPGTLDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAVNVPLYVNLMKNEEVLVSAYANDGAPDHETASNHAILQLFQGDQIWLRLHRGAIYGSSWKYSTFSGYLLYQD
The following text describes a protein:
Function:
Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Also binds the DEAR/FBXW7-AS1 receptor. Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments. NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2.
Subcellular Localization:
Secreted.
Sequence:
MELHILFSMMSLLYSGLLQTVSMSLSQETSSVSSAPWRHIRTKRCSCSTFLDKECVYFCHLDIIWINTPERTVSYGLGSAPRVKRALRSFPNGLTHGDSRCTCASKEDKTCATFCRSENLQRLQSTDVKLQAVSAEAQDCTGWQCLYNLAANKRKITRGRFGKARALLANVKLRAKHLLKKKEERRNHKSKLWESLMSAS
The following text describes a protein:
Function:
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Sequence:
MFRIVAVPEFSIQTVDARDPSSSEAAETLAALREKLSPRGDLVSPRGRELTLKVFGKALSPIEVVETICKDVQSQGTEALLRYTKSLDGAELTADTLRVPEEDLKAAHAVADPKLIETIGRIRDNIATFQSAILHRDVTITPRPGVSLTQRYVPIPRVGICVPGGAAAYPSTVMMTAIPAQVAGVDEIAVVAPPTPFGAYNTDMLATCHELGIKEVYRCGGAQAVAAMAYGCDALPAVDKIVGPGNLFVALAKKHVFGTVDIDSFAGPSEVIVIADESANAAFVASDLLAQAEHSPGSAILITWDESLLTSVQAELSRQLGELERGDLARDALSDFGALVLARDADHACELTDSFAPEHLQIETREPESLIAKIRHSGAAFLGHHTPVALGDYAAGPSHVLPTGGTCRWAAGLSANSFLRSGSVTQFDQSALSAIAQDVITVAEKEGLTAHARSISIRTE
The following text describes a protein:
Function:
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.
Subcellular Localization:
Nucleus.
Sequence:
MASYGDDGVELTELTLGPPGASARRARRGRKNGHPPPSSSMIQAAYFVKVSMDGTPYLRKVDVAAYGDYLELVEALNDMFYCSTIGLMDGYGEWEHAVVYEDGDGDWMLVGDVPWEMFVSSCKRMRVMRACEARGLSSNA
The following text describes a protein:
Function:
Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. Component of the terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) in embryonic through to adult gut cells. Correct localization of filaments requires let-413.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAVSYSMHRTTTTTSSSSHGGVSAGHAAEEFVASAEREKQEMQQLNSRLEVYISRVRQLEDRNKELVIELDTLRGSLGNDIGQIKFKFNDSLVKVRREISEAHSGTIGVEVKVDRLRDDLNDYRHRYEEARREVEREKTTWGGAISQAQAELDTNKSRYAAILDEEKRLYAEQDQLYLQLAAAKDELDAAIVDRRRLQAEEDDLKIELEFLGRIHSQEITELRTLLAQAPADTREFFKNELALAIREIKAEYDKIIQTTRVDLETIFQSKISAVESSIVSKNEAAVFRQEEIRKMNESITTLRAKLSELEARNSALEREANTLQIQLGEDQRAYESELHKRDNALRFMREDCQTLIAELQALLNTKQTLDTEIAIYRKLVESEEGRFTHVGQGVVVAQQETTRLVPVEQDHWDSGEVQTRSSFKRHAKGNVSIVECDPQGKYIILENTSGSVAEDVSNFEIRRVIDGVQAFVFRLPSHLVIQQHGHLKIYGRNSGGINSPPDSIVMESHPSWGQGGQVETFLYNSHGIEKASHIQTTVASSR
The following text describes a protein:
Function:
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.
Subcellular Localization:
Endomembrane system. Golgi apparatus.
Sequence:
MSSFQLQNSEVLARLKPFGISFEKSLNDLIKGIRAHTKESPESLGNFLDVAIQECRNELTTTDLETKAMAILKLAYLEMYGFDMSWCNFQILEVMSSSKFQQKRIGYLAAIQSFKNEQDLLILATNQFKKDLNSHNHVDIGLALSGIATIVTPSLAKDINDDVLMKLNHSKPYIRKKAILAMYKIFLQYPESLRLNFNRVIEKLDDSEIAVVSATVNVICEISKKNPNIFINYLPKFFAILEDTKNNWLIIRILKLFQSLSKVEPRMKKKILPTIIDLMLRTQASSLIYECINCIVSGQMLSADSSKDKETAKLCINQLKLFFLTNDSNLKFVGLIALINTLKIFPILINDVEGISEIVLECLNDRDLIIKRKALEVSNYLVNEDNITEVVKIMLMQLVPDNNMIDDMLKLEITLKILQIASQNNYVNIPNFRWYVAVLKDVINLTLLPVEGATNSGLIASHIANEISTEVGKEFKNLATKVPSVRSYLLQNVVLELVQDVRLLDSSALILKDLYWILGEYISELKVTQNDDGDDDSDSDSDGEDAQVMVLDIDKKIKVFNTLINYQIDKKLGLTSNIHFPVSAKLINLHFTSVVAVLIQALVKLYNGIATDYINNFATTNGQLPLEKYHELCYHLYRLIGFLSNWENHPNYEVQERALSWLEFLKLILEAMTDNDFTDIKKLEESDLKMYKDLPIAKGGDSESESESESEDDDEEEEEEEEENDYSEDDSESEDDGYENLVSSDEEGNSKPSKSTLPIQEEEYNPFAENEESESKNLTGGNEAEEETQEQENQQEDDNGMKQLPMLLTHVLPSFFTAYTLNPVAKNAQRNVGVPEDLDLNTQIHSPDFKLEQFDDDSSDSYELYLSEVEDMEPLIHLSSDEPQEKKKERLERLKDDPYYLDDDAVVKTKKKSKSKKIKSESISPDVESENASITNTIVSETDTDMNKKKKQTKKKKTNKLKKEKVLILDEETIVGESNITTPIESTQIQTHKEKKKPTKKNTFKIDSSNLDNFDLVSNDSETQLHNDKEYEIDLEALREKLKKTTVEPKIKDKEAKSKKKSKKSKKTSEEGKSTTTESNGVEPLKPKKVKKKKAIILE
The following text describes a protein:
Function:
Required for the regulation of germline mitosis, karyosome formation, and establishment of dorsoventral (DS) polarity of the egg and embryo. Involved in proper grk mRNA localization and translation in the oocyte. May control germline mitosis by facilitating the cyclin E (CycE) proteolysis by the SCF-ubiquitin-proteasome complex.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Splicing donor and acceptor sites between exon 10 and exon 11 are not canonical.
Subcellular Localization:
Cytoplasm. Note=Colocalizes with grk.
Sequence:
MSSTKSQVALATNIPTNLSSAASASTAAAAAAVVVVASANAAVASSANSSGVGSGSGPGPGSGAGVSGPVAAGTATAVATGSTVTAATSVAATTSTSVATISTSCSSSSINNINNNCGEECQSAAGSSNLGRQNSFGNRRGNMKGKHLTRSHAMRESTSPPRTPTPRAASEQQQQQLQGEQHEHNNNNNINSSSKAQSAGRGNSPLMETPAVIVTSQQPQQQQQQQQQQQQSVPPKPQQNVPLSNEAEFPKLSPPKKSGGQHNRTNSNGSGMEFNNNNNSSNKKFVVDMKANGLDNKPHNNSSTGVIFNSGMNYKAAERHDRHERHEMSSQNSNLSNNHDEEPYHYEPRGGGGGKKHRANTNAKGNKPRLKNLGGSSSGSIDLGGGGGNGNCNNMSNNGQSNNSSNNTSGFISRENSSEQYTDYGGTDLLVFFRDTLNKNPKDRNILLKIEKDLIDFVQENSRGCEYRFPPASSYNRMLIHRTAAFFGMEHNVDTETQQCVIVAVAKNTRIPEIRFQSLVRDDARKSILKRDTHSFDEVRQSPYLCPLSLDRKAKSFEEREEDYDRARSRIFSRTGGNHDGYSGGGGDEECYGGWEQQQQQQKQSQPPRPKRPNGKMLQMQNSTESRDGMRSGGAVPKSHNFGNYGGPPSSGGPGNNSLPRGDSTNSIKSGRGGFVKQDSTGSTPWRLSPSSSGSIYHYDPSNLPPNQALQHSGNQYQSQNQGNSSSGGYNNYRKSSPHQQQQSQQQQQSQQHHQQQLQQPQQLHQQSSQQYATTELSCSSTESYAEEEAQSPGMECSEGYESYEQQSLPVQQQLSGNGDSASTKGDDCDSLASATACLSITTSTSTKNYDRIEVQKYKNQATSPNIPACCAVGEKLELEAGLPQEQEQEPMAGPSSSGSATSSVGITELPSSQTPLPMVNQVNCDLQSVSPSTTPYSQCEVKTPSQNHAPSAAVEEPKTTTWTYTQSYQAPDGSTVFHTTTTPNGAAPYCATTYQQGPDGSIYAVPQGMVYAAYPQPGVGTAGGASQPLFQLTTSSHPPAQTIFASPEAGAEIPGGTYMIPVFDPAQQPREGLIPAQAIYQTGPGGPGATTVMPMATAAAYPTAQFATAAPNGAPIYQAPLIYSSEPGGGAQLQQLPMAPYPIQYSYPYYHPISYYVPQQAVAAAPMVASQPQVGQAPMQQQAPHTGAGTTTGPPTVVSVSGQQHHQPHQQHHQQQQHSSNGSVVTSSAYGTRVKRTPGGGSIHYNPSYTPSSVAHAGGAHHPSAGSAQIIAAPAASTTTYHALPTLTLAHGGPATGTDLSGAGGAHVYALPAQHALIPTNIFPYAAAAAAAAGGPGGPPTTPQVVQQAPPPPPQSAPHHALITAAPFYPANGGNMDQGASQSAPSTPAAPGRQAPLFSTPPAPNNGSSGSSSAGGGGNSGGYHSNSSTPHYYQGQNSNEGYTSPYEKRNHGGGASGAHSVGVRKPYHPGGYNPRHSVPLGGIPSGAKTPLLNSNNEPTPRASPSSVSLGGASSSGGANSYPHRGPPPHTMGVKRDNKPNQLPLISGPPPSYAANSSPGVSSYESKPPVRLNAGAASFRSQKSMNQDYRRSVSQRNSPSANGGGSGSHESSNNSPNSIVGSQSNSAANTPNAAAPPPPQPQPTLVSHSGGFVVLDQTTGAAMNASPPSLYGGGGGPNAGISGGAGASGAAGSNGGHQPGGGGGARSHIPTAQLHHSAAAAAAAAAGSQQATAAVLSGVAAAAALGGYNPNGASGVYFKYGQTYFAHPSVALPNSRRSPSNDIRPQMAQVAGMYPTMMIQARHPSRHPNPNYKGSRPR
The following text describes a protein:
Function:
Catalyzes the synthesis of Z,E-mixed prenyl diphosphates by a condensation of isopentenyl diphosphate to an allylic diphosphate. It shows a large substrate specificity accepting dimethylallyl diphosphate (DMAPP), GPP, E,Efarnesyl diphosphate (FPP), E,E,E-geranylgeranyl diphosphate (GGPP), neryl diphosphate (Z-GPP), and (2Z,6E)-farnesyl diphosphate (Z,E-FPP) as allylic substrates. The enzyme exhibits the highest activity when Z,E-FPP is employed as an allylic substrate. The major product is dodecaprenyl diphosphate (C60) under every allylic substrate conditions, but the enzyme is also able to synthesize even C70 prenyl diphosphate as the maximum chain-length product.
Sequence:
MSPKTVFSTDTHREPIPPQPHPSGARPPQLPRELIPRHVAIVMDGNGRWAKQRGLPRTEGHKAGESSLFDVIEGALELGVPYLSAYAFSTENWKRSPDEVRFLMGFNRDVIRRRRDELHARGVRVRWAGRPGRLWKSVIKELTEAEELTKHNTKLTLQFCVNYGGRAEIADAAAALARDVAAGRLSPNRVTEATLARYLYHPDIPDVDLFIRSSGEQRLSNFLLWQSSYAEFVFLDTLWPDFDRRHFWQACEIYARRDRRYGGAEPNPVGPPQSAAGAQGQD
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Plays a critical role in the development of the central nervous system (CNS).
Subcellular Localization:
Nucleus.
Sequence:
MASEGTQQNPSCKIMTFRPTLEEFQDFGKYMAYIESHGAHRAGLAKVIPPKQWRPRRTYDDLDEMVIPAPIQQVVTGQSGLFTQYNIQKKPMTVGEYRRLANSDKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDNDINLWNIAGLNTLLDMVEHECGIIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAVPPEHGKRLERLAKGFFPGSSQGCDAFLRHKMTLISPSILKKYGIPFDRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDYGKMATQCTCRKDMVKISMDVFVKFLQPDRFEAWKQGKDITILDHLKPTELSSPELEAWRERRSQLKDKTDHRPYRKRTQPRRHKTQDQKLLQKVLGCNLMLGNQDVEVKNCEEEEDFSKKYEGHLVDMKHNLCETKPKNEKRRKKDRVEKSSGILPLTAGLLLNPPELDRVTSFISGPPDFSDEIEFKPHPIIPTLYVVPQDKKVVFDKAQMSCQEAFEQFARQGTHSGKAAEPKGKSKEAQAPVLFPKMEIKKSWRHPLGRPPARSLMSIVKQEMSSDDDSTPFSGEEDVSDHEALRTLLSHLWKNKPHNFLAERKFNAAAALIEPYCAVCSIFFPYHKESACLSQSIIPSSKKGQKTKALIPEMCFSASGGSGDPLPVSTYNAEDGTSILISCAKCCLQVHASCYGVNPDLLVENWTCSRCTTCAWNAECCLCNLRGGALHITTDKRWVHVVCAVVVPEARFKNPVERQPVDVSTIPEQRCKLKCIYCRRKIRKEGGACVQCSVDRCSTSFHVTCAYTAGITMEPDDWPYIVSITCFKHRASNHSYSFSREVSIGQSVISRNRNGLYYRCQVIGSATQIFYEINFDDGSYSDNVYPESITSMDCLQDGPPTEGQMVELRWTDGNTYKARFISANVSHVYQVEFDDYSQLMVKRSEIFTLEETLPKRVRCRLSLSTGASLEDLSEDQKSCKRPRVASPSNLEQESKSHEIVGPNHPLTQSQYPK
The following text describes a protein:
Function:
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MRINKPFSDDSNTVVFVSSKTYGVKEEAAHNPNVEFGVVLPTDFPAFNRALVQFLKRKKTKLNINLDSLIELYKKNENSGCFHTAIKTVITSVTFCETTPFTMKTKPEKNVEVAVQCAVEYHNLVKEYETVGEYVNLARELQDTPSDLLYSEVFVKHFEKAASKLPVKIKVLKQSDLIKKKMGLLLGVNQGSEREARLLVISYQANKNSKEKLAFVGKGITYDSGGMNIKTGDYMRGMKYDMSGAAIVCSTVLALAKNKVKTNVVAVAALTENLPGAKAQRPDDIKIAYNGKSVEIDNTDAEGRLVLADAITYAAKDLAATHIIDVATLTGLMSYILSTTYTGIFSTCDHQWESFKKAACSAGEPVWRLPMHPDYLKPLQLTKLADLQNSTSARGAGSSRAACFLAEFREGVSLIHCDIASTASIENLGQGVLVRTLYERASQLANK
The following text describes a protein:
Function:
Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Appears to favor the formation of acetate. Involved in the secretion of excess carbohydrate.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTISVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVLLTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLYSLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEGGKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGISGFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENSVEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVRLAK
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MGSGDLNMKKSWHPQRSGNVAATQKAEAEAIAERKKLQQRLQEIEEERRKEEIQKALEAAGGKRKIDRVEWMYSGPTDGQAGDSAETEAYLLGKRRIDKLLQDNDTKKALSKQSQQDVLSAAGPAPVVTNARDVATKIREDPLLAIKRQEQQAYEAMMNDPIKRRQLLASMGIDDSQIAAKGGKEQRRHKHRSHHHRSDRHRDRDDDRDRDSARDRDRDRHSRRRRSDSRDRSRSRSPRRRSDSEEDRSKQRRRDSPDRTRRRDRDQSRSRGNRDRDDDRSRRHRFPQGRSRSRSGSPGGRSSRRREYSRERDSGGPSSRRDDRNSRDQNRPRRDYAKEDEQPKYDGGLNKGGRRQQQPDGDHKNAEEERAKKLAAMQAAATDLDKAREERLKALAEAERAEREADEKARQQNKKFRGGDAGFMSGLHSRAADMKIADRMNGRV
The following text describes a protein:
Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Domain:
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
Sequence:
MEKSLDLSAFNKSDRDKILKKINKAEYEDTMNTYNSIVERCFNECITSFRSKELDNNENNCILNCVKKFSIFSQRIGMKFTQNLNNEMQKKT
The following text describes a protein:
Function:
Putative DNA-binding acetyltransferase.
Sequence:
MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILFEIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGKTIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFLSEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKHDEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKKFGFRISEVKQEAPLWGQQLTEERWDLELS
The following text describes a protein:
Function:
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.
Sequence:
MSRVVITGVSGTIANRLEINDFVKNDKFFSLYIQALQVMSSVPPQENVRSFFQIGGIHGLPYTPWDGITGDQPFDPNTQWGGYCTHGSVLFPTWHRPYVLLYEQILHKHVQDIAATYTTSDKAAWVQAAANLRQPYWDWAANAVPPDQVIVSKKVTITGSNGHKVEVDNPLYHYKFHPIDSSFPRPYSEWPTTLRQPNSSRPNATDNVAKLRNVLRASQENITSNTYSMLTRVHTWKAFSNHTVGDGGSTSNSLEAIHDGIHVDVGGGGHMGDPAVAAFDPIFFLHHCNVDRLLSLWAAINPGVWVSPGDSEDGTFILPPEAPVDVSTPLTPFSNTETTFWASGGITDTTKLGYTYPEFNGLDLGNAQAVKAAIGNIVNRLYGASVFSGFAAATSAIGAGSVASLAADVPLEKAPAPAPEAAAQPPVPAPAHVEPAVRAVSVHAAAAQPHAEPPVHVSAGGHPSPHGFYDWTARIEFKKYEFGSSFSVLLFLGPVPEDPEQWLVSPNFVGAHHAFVNSAAGHCANCRSQGNVVVEGFVHLTKYISEHAGLRSLNPEVVEPYLTNELHWRVLKADGSVGQLESLEVSVYGTPMNLPVGAMFPVPGNRRHFHGITHGRVGGSRHAIV
The following text describes a protein:
Function:
Functions as an E3 ubiquitin ligase.
Sequence:
MDPVPVRCLLNSISRYLHLVACHTIRYSPIQTRIGNVVHLLKLLKPFLVEVVDCKTPPDDGCLNSACEDLDSVVNQAREFLEDWSPKLSKLFGVFHCELLLEKVQTCSLKITGILLQLSQSSAVTLSLQGVERCMQEIECFKQENTLTEHMNNALQNQTDDNDDLDSIIQMIGLVSNQDLLKESIAVEKEQMDQLIDLVSCIREHMLKTEFLEVAKGISTPPYFRCPLSTELMVDPVIVASGQTFDRTSIKTWLDNGLAVCPRTRQVLTHQELIPNYTVKAMIESWLEANNITLAVNSGGDDSSVANNMGSNDFNRTESFRFSLRSSSFTSRSSVEAGNGFEKVKINVPASLSKELEIFELSSQEQSYTHSRSESVCSVVSSVDYVPSVTSETQSLPVNHQSYSEMSSGTMMTSHTIKLVEDLKNGSNKEKTDAAAEIRRLTINSVENRVHFGRCGAITPLLSLLYSEEKLTQEQAVTALLNLSLSEVNKGMIVEAGAIEPLVHVLKAGNDRAKENSAATLFSLSVVQVNRERIGQCNAAIHALVSLLGKGTLRGKKDAASALFNLSITHENKARIVQAKAVKYLVEMLDPDLEMVDKAVALLANLSGVGEGRQEIVREGGVPLLVETVDSGSGRGKENAASVLLQLCLNSPKFCTLVLQEGAIPPLVALSQSGTQRAKEKAQQLLSHFRNQRDARMKKGRS
The following text describes a protein:
Function:
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).
Sequence:
MENASREQNSQPIGKKEHSVINGSIKRSKITYHPITTALLTVYGFLKLIYLRFGGMLFYPSDYFEAANFVDGLFDTAGHRNEISNWNVLKRNLFNTQALVAIAQERYHVVGYPYVGNDAPVGKLYTLKAHASDDWNMPDLNSALGINIAKPKTLEDRIRIAENFILDYNYDIPMYVDSIDNDTMEAYGARPERLYIIVNGKIAYKGGPGPYCFSYSSLEESLLKVLKQL
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSSSSSSHVHVCHVWAANLEEEFRHIDKCLHPDCRQFTFVSMDTEFPGTIYNPEGVPPYMRAPEEFYSNIKQNVDALKLIQLGLTIFDRYGNLPRSAETGQEQIWEFNFQFDSAIDPHNKESHNKESMSLLEKQGINLSRNKKYGIDPREFAMQFKCSELGRRSYYGRVVWITFHGLYDFAYLTKILNGGELLLPDDLDEFMRHVWKYFKGNVYDLKSMILFVGLHGGLEKVARSLNVKRVVGKRHQAGSDSLLTMHAFFGLMRSCLEKGGRDPRGVNLMVAGRTGLEMMQTLFGLFGLMKRNSCSGSDGLLMMQTLFGLDARPVF
The following text describes a protein:
Function:
Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.
Sequence:
MRLVWFRRDLRSFDNTALTAALNSGDPVAAMYIATPEQWHQHHLAPIQADLIWRRLAELQQELAALNVPLFYQQVADFQAAAVAVSQLAKTLNATQVLANRDYELDEQQRDQLAQQLLSEQGIIWSAFDDKCVLPPGSVRTKQGEFFKVFTPFKRAWLTLFQPPVIGKNRPVALWNVPSALAELVWHPEQAFDYPRIDSTPWAADFETVRAQLRDFCRERVQDYHQARDFPAREGTSSLSPYLAIGVLSARQCVARLYHESSMGELSEGAQVWLSELIWREFYQHLVAIEPNLSKSRDFVEWGARLEWWNDNEKFQLWCEGKTGYPIVDAAMRQLNQTGWMHNRLRMIVASFLTKDLHIDWRWGERYFMSRLIDGDYAANNGGWQWCASTGCDGQPYFRIFNPVSQGEKFDPNGDFIRRWVPELRSVSSAYIHQPWTYPAVNSVLYPARLVDHKQEREVTLRLYKTAKG
The following text describes a protein:
Function:
A major component of the extracellular matrix of non-articular cartilage (By similarity). Binds to type 2 collagens and forms long concatenated protein networks as part of the extracellular matrix (By similarity). Required for the network-like organization and bundling of collagen fibrils surrounding chondrocytes in the zones of maturation and hypertrophy. Required for mechanotransduction and adaption to mechanical loading in cartilage chondrocytes, resulting in an increase in expression of the extracellular matrix components ACAN and COL2A1. Acts as a moderator of angiogenesis in response to injury.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MKVTSGPAFALCSLLLLLLLLLQVPDSLSLVPQPRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGLVNYASTVKPEFPLRAHGSKASLLQAVRRIQPLSTGTMTGLALQFAITKALSDAEGGRARSPDISKVVIVVTDGRPQDSVRDVSERARASGIELFAIGVGRVDKATLRQIASEPQDEHVDYVESYNVIEKLAKKFQEAFCVVSDLCATGDHDCEQLCVSSPGSYTCACHEGFTLNSDGKTCNVCRGGGSGSATDLVFLIDGSKSVRPENFELVKKFINQIVDTLDVSDRLAQVGLVQYSSSIRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYINDAARKAKDLGFKMFAVGVGNAVEEELREIASEPVADHYFYTADFKTINQIGKKLQKQICVEEDPCACESILKFEAKVEGLLQALTRKLEAVSGRLAVLENRII