lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcription factor; part of the gene cluster that mediates the biosynthesis of a methylated derivative of known natural products orthosporin and diaporthin. Positively regultaes the expression of the non-reducing polyketide synthase aoiG and the O-methyltransferase aoiO.
Subcellular Localization:
Nucleus.
Sequence:
MSTGSTLNQRSGKPVKLRASCDFCALSKVKCDRGQPQCVRCIKSGIDCNYSESRRIGKAWHHCAPSAVRSTSATTQGTRRKQQTIAQHSPRRRIHRDTQALSAADDAMSPYDPSGYATPFSMFHTLPSPVPESTIRSQTHIESYPSLDGTMAPILCSPESADISLPDIPHVAQLRTNELEGESPSVLQYNPSWDRIMAEHSTAIGDAGDCITRAAAVLKSVRDPRTSCVRSRTPPRSHTQSLDATLDDGRTAMDTVKDILACPCAQEIRVALLLVLIIQQVLESYQALLTQQHDTPREESPLGINLSRYDTPMAIGRYLLDNELRSKIIVQVLSSELEKIGLILDILTRHAQSMAHQPDELILGTYIDSLQTTKKEVLESLEQGNDI
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MNVTLRQLRAFTGVYRTRSITRAARELGITQSAASLLIQQLETQLGVKLFDRSTRSVQPTLAADEAFHSAERMLGDALGLSRRMRDLAQARAGRVAFLASAGAASALLPLVLAKFRAAHPDIEIDMRDVAADDLVPRLIATDAEFAIGSVEGEFAEMTIETLTRGRLSAIGRSTADFAARRALTWDELAQLPTIAMRRETRIRMQIDQALGAQGKHLNPTYEVTLINTALAMTAQGLGLAILPATMLPADQFPTLIARPLIRPAITRPVSLLQRQGRTLSPAAQAFVAMARTVLAGP
The following text describes a protein:
Function:
Cell autonomous antagonist of the canonical Wnt signaling pathway.
Subcellular Localization:
Cell membrane. Cytoplasm.
Sequence:
MGKLYSKHAAVCKPRESPEGDSFAVNACLARKGIEDWIVKQKPPNSSLKTGYRITQRLEKMLNDACISGWITSDLRDGLFVEHPHWPIIKTHIELSAINRKRIQFGYRRNKNLKELLSPTDPDSNGDICKYNIANEHFHLEVALPEEKSEGLFTSDDRKVDKDNDGRVKKQHKFEELQCDVSVEEDNRQEWTFTLYDFDNSGRVTREDITRLLHTIYEVFDASVNHSLSSSKTLRVKLSLAPDATLKKRTVLVNHAELQNGRHRSECKVTENLRGSEKKQQGSGRLENVTEQTECLRQCVDENIERRNHYLDLAGIENYTSRFGPGSPPMCEKHDSQAKASNQMRSRSHEPETISFHHRRSQALDTGNSNMTELSHVKVAEVQQRQRGQENNKHFVRSPRASNKNGHLSTSQPGRTRNKPSQGVSMPVNPPSAFMGQSYLYHPVPPQSVHRKSKQKTKDGHQMRKAFQSPVNVVEKEHVRDLPSMVLYDDQVGHMIQRHEHHHHHEHHYHYHHFYQK
The following text describes a protein:
Function:
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
Miscellaneous:
MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTAVESRPAGVIGTSQSPSHRPFGARVKAFVALTKPRIIELLLITTVPVMFLAEQGVPNLKLVLLTCVGGYLSAGGANALNMYIDRDIDALMDRTSQRPLVTGMVSPVECLVFGITLAIVSTLLFGFTVNWLSAWLSLGALLFYVVVYTMILKRRTSQNIVWGGIAGCLPVLIGWSAVTNSMSWAPVILFGVMFFWTPPHYWPLSMKVKEDYARVGVPMLPVIASNKVVARQIVIYSWVMVVVSLLLQPLGYTGWFYTAVALAAGGMWLWEAHGLQNRAKAEVTGGKLKEMRLFHWSITYVSVLFLAIAVDPFLR
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MDKVQIALQNKFKKNNKLAITTLRKANQFDCLAVLIGTSHTSNIGIQKGFQQWYLGCELMDCILIMSTKMLCIIADEVMFQKLKHLSDIKMKTFTIFFLIKNIKKNNHQQFQFALERLRKEYPGNNYRLALNLSDGQKSPLITEFNQFIDQNHLIKVDCTSFLKELINNDNKDIFEYYNTCGKINSYYMKFMSQRIELAIKFNENTTNYSITQAVKREKSSDLNQMAIRRKFGLQGNYDILSSTVQSGGQYNVSASESTQSRLVGDVVIYSFCCQYMQSQSYCTRTLLFQPNQELEQIYRVILNVHAFALGLVKEDIQFKQIYRETQNIWETIFKDDPEMKMKFPTDIGYLIGSQMLIDNHNIETIQDRMAVVIRMFVDNILVQLPFYPERTNIAICLADTIFVVSGIEDCVITKAEKEFTFVSYQPTEEGERFFKSTFQKNENSDVLHQSEKITREQFEQAELNKIKNDQEKLKEIKQYELEVRLNDQQTRQEPKLLVKMDQLQAFQKEDQFDQYPKGEIAVDQDKSAILIPIIGTHYPFHALTIQNVSVKELPNGAGEITIRFWTNEFHIDTREFPSMDQDQMFLKEITLRNQEFIKLQDIENEINVCRDDARRKQIEKQLEVDKFDFVIEKLTVLPKNTPCLSKVYMRPTQSQKTRSPEGFVECHENGFRYKSARGEVIDFTFTSIKHCFFVSPEDEVIACIHFIFKMPIKCGKIMFSQIQFYRDIEGASEQEAARRKVRLFDIDHVFDKKVQDRRLEELKNFESFIQQSEQYYKRFNIKFERLEKQYSFEGNYAKERVVFQPTQSCLVNIVDQPFFTLTLENVDIMCCERVQEETISFDLVAVLKDLEAQVIRIEAIDREDLKKIQQWLNKKKILFFQTTSGLMWRNMQFSIQKDFPLFVYDGGWATMMKDHMEHAPIQQFNDEPLFEPDSSNGPTSVSEFEFEQDKKNNKYLHLQKDDESDFSDLVDSEDIMSELDIQERRKRKKVKYNFID
The following text describes a protein:
Function:
[Brain natriuretic peptide 45]: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart. Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Likely involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, kaluresis and chloruresis (By similarity).
Subcellular Localization:
[Brain natriuretic peptide 45]: Secreted. Note=Detected in blood.
Sequence:
MDLLKVLSQMILFLLFLYLSPLGGHSYPLGSPSQSPEQFKMQKLLELIREKSEEMAQRQLLKDQGLTKEHPKRVLRSQGSTLRVQQRPQNSKVTHISSCFGHKIDRIGSVSRLGCNALKLL
The following text describes a protein:
Function:
May play a role into cellular response to oxidative stress. May decrease cell proliferation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSKATKRKHVVKEVLEDYVTPTEDQQIMRVLGSNGNNLHEAVTGSGERFLLSMPTKFRKNIWIKRGDFVIVDPIKEGGKVKGEISFILYRDHIQHLRKLGVWPEGFQEDRTSGERNEGTQKERSEEKEEEEGDSESEDDDSDLFVNTNRATVLYSESEEETDEDEEEDKGRA
The following text describes a protein:
Function:
Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MMGAAMFLLGLCLCFSSVSADSKAVTTSITAKWASTPLLLEASEFLAEEAPDKFWAFVDEVQQVEDQGSDNINYELMVNKASRQLSPQQENLLKFALSLRTYSATVQTFQQMAADEPPPPGCKSFLAVHGVKTCVLENLSSLLKTASDRPKPFLFKGDHRYPSTSPDSPVVILYAEIGSGDFSRFHQMLSLKAQEDDIIYILRHYVSQPRPEKVYLSGYGVELAIKSTEYKAKDDTQVKGNDVNATVEGEHDPVDEVQGFLFGKLRQLYPELKEQLKELRKHLIDSTNEMAPLKVWELQDLSYQSAAHVLSAPASESLMVMKDLSQNFPTKARALTRTVVDSALRKEVEENQKYFKSNLGLHPGDSALFINGLHVDLDSQDIFSLFDTVRNEAQVMEGLFRLGIDGTALQNVLKLNIQPSTADYAVDIRYPAITWVNNLELDSRYNSWPSTLQELLRPTFPGVIRQIRRNFNNFVIIFDPVQESTTELVTLAEMFLSNHIPVRIGLVFVVDDSEEVDGFQDAGVALLRAFNYVADEMDNYHAFQLVASIYNKVPAGKRLTVKHVTSVLEQKYPYVELGSILDRDSAYDQSRKEGMEYFLQTGLTPLPVVLFNGIPFSKEQLEPDELETATMHKIIETTTFFQKAVYLGELTNDQDVVDHIMNQPNVVPRINMRILEAERRYLDLTTLNNFFVDDYKRFSSLNSNAKSAAIVNSMTYLTKKGMSSREIYDDSFVRPVTFWIVGDFDEPSGRQLLYDAIKHQKSSNNVRIGMLNNPSQDPSAERTRVARAIWAALQTQNSNNAKNFITKIVKQENAKQIEAGKDPVEFAVGGMDTSLFLDVFESAKVDFILSHTLYCREVLKLKKGERAIISNGRIIGPLRDNEVFNQDDFHLLENLVLKTSAQKIKSHVQLLQVEEDHASDLVMKIDSLLSSQPKGEGRVSYQIPEDQHSAIKLRPTEGMIYFDVVAVVDPVTKAAQKLAPLLLVLNQVLNMNLRVFMNCQSKLSEMPLKSFYRYILEPEVTFTSKKKFAPGPIAKFLDMPQSPLFTLSLDTPESWMVESVRTPYDLDNIYLEEVDSVVAAEFELEYLLLEGHCFDVSTGQPPRGLQFTLGTSTNPVVVDTIVMANLGYFQLKANPGAWMLRLRKGRSEDIYTIYSHEGTDSDPEASDVVIVLHDFKSKIIKLKVQKKPDKMNEDLLSDGTSENESGFWDSLTWGLSGGQKQEETKADKEDVLNIFSVASGHLYERFLRIMMLSVLKNTRTPVKFWFLKNYLSPTFKNFIPYMAEKYNFQYELVQYKWPRWLHQQTEKQRIIWGYKILFLDVLFPLAVDKFIFVDADQIVRTDLKELRDFNLDGAPYGYTPFCDSRREMDGYRFWRSGYWASHLAGRKYHISALYVVDLKKFRKIAAGDRLRGQYQGLSQDPNSLSNLDQDLPNNMIHQVPIKSLPQEWLWCETWCDETSKKKAKTIDLCNNPKTKEPKLQAAVRIVPEWQDYDQEIKKLQSHFQEESSNGSLQPDKSTNPDKEFHVEL
The following text describes a protein:
Function:
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.
Subcellular Localization:
Cytoplasm, P-body. Nucleus. Note=NANOS2 promotes its localization to P-body.
Sequence:
MPRTSEKQLGDGPGEGVVASVPGLRREAGFLLEWAVGHPEPHSGLDSLIPQLHNAANANQKEKYEADLKKEIKKLQRLRDQIKTWVASNEIKDKRQLIDNRKLIETQMERFKVVERETKTKAYSKEGLGLAQKVDPAQKEKEEVGQWLTNTIDTLNMQVDQFESEVESLSVQTRKKKGDKDKQDRIEGLKRHIEKHRYHVRMLETILRMLDNDSILVDAIRKIKDDVEYYVDSSQDPDFEENEFLYDDLDLEDIPQALVATSPPSHSHMEDEIFNQSSSTPTSTTSSSPIPPSPANCTTENSEDDKKRGRSTDSEVSQSPAKNGSKPVHSNQHPQSPAVPPSYPSGPPPTASALSTTPGNNGAPAPAAPASALGPKASPAPSHNSGTPAPYAQAVAPPAPSGPSTAQPRPPSVQPGGGGGGGSGGGGGGGSSNNSSGGGGAGKQNGATSYSSVVADSPAEVALSSSGGNTTSSQALGPPSGPHNPPPSTSKEPSAAAPTGAGGVAPGSGNNSGGPSLLVPLPVNPPSSPTPSFSEAKAASTLLNGPPQFSAAPEIKAPEPLSSLKSMAERAAISSGIEDPVPTLHLTERDIILSSTSAPPASAQPPLQLSEVNIPLSLGVCPLGPVPLTKEQLYQQAMEEAAWHHMPHPSDSERIRQYLPRNPCPTPPYHHQMPPPHSDTVEFYQRLSTETLFFIFYYLEGTKAQYLAAKALKKQSWRFHTKYMMWFQRHEEPKTITDEFEQGTYIYFDYEKWGQRKKEGFTFEYRYLEDRDLQ
The following text describes a protein:
Function:
May be involved in the metabolism of very long-chain fatty acid-containing phospholipids (VLCFA-PL).
Subcellular Localization:
Note=Localizes to small particle-like structures, that differ from either the mitochondria, the endoplasmic reticulum near the nucleus, or the peroxisomes.
Sequence:
MVGTINESMQNMKIGAKETAQSAKQGIKNAGQSSSKTARDVMGNPVPGSYTAGNTANDGDSSYASSKNLPGNADIGATSSERTAYAAPQRAAVDTSNVSPPSTQTGGYASKDTTSTYEGAQPLSSQSSRSSNYTNVKITATQNNVDALTGAPIRIVTTTNARIQPDEKTLQDLLEQRQVALREAREAEEELQRARQYNDRSTSEALELEARAKKAAQDAELASERAREAQSSIERSASLREKQAREEAERAATALREAELKHRLAQANADVDVANSKLDIALKNEAAWKAERESSLAHQKAVIDSARAELERARHEAAVADATYKKEHYEYNALVAELEERNDNTLRTASIREAEARNLEVHMEDTLKDARMRSRNATEQVEVVKREINSEIDVYRSSVEKTKAELASYQKGLPSQKEACDRELDDATRALQAAFQDRFNAAKLRVNQFDVDSRQQLAMLTKKVRDAEDAEEKYRISCHQREEEITRCATQAYDAVKAAEKRNETIAEAARAKENEAKDLYSKAESITQDLNAKRSHPPQPANLDYSSAIQRAQERLTLEESKLTDLRTAEPSQYVNDVEVARRALRDAQAEQSKVESEYNSVKGSKLYTTEPVHPHAVTTNEPTDVSTKSKSAAYHYPATTETVSSKAARSATTPAYVGGATKTPSTTKAVESTPSTLPTSASTNAAATTTTKKPKAAKSTAVRDDVSSASSDSDKGTTGLGKSESKSSRKERRSSTSSGHGLMNNVRHALGMSNK
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Subcellular Localization:
Nucleus.
Sequence:
MASSAISTPSRSRKQVITFDDDDDEEEDDNNDDEDDSNSSQKKQKGKPFGKKDKKEIEQRYSFLVDVKDGNGNKKGSPDYDPRTLQIPASCLTKFSPFERQFWDIKSKYYDTVVFFKKGKFYELYENDADIGHQILHLKMTDRVNMRMVGVPESAFTHWASKLINLGYKVAKVDQMETSIGMNKRQNEKGGRNKKDSIIQRELTSILTAGTLLDESMISDKTSTYLMAIKEDEYSNKYGVCFVDVSIGEFFLCSIDDDENRMQFETLLLQMMPKEVVYEKGAISAKTMSIMKRVLATVKPVMNARLSLEYWDPSETLNRVNDSCGRIPESLKEMKNETLLICSLGGCLSYLSDIKIAQQVLEQGRFKRFNSLDVGNSLILDGQCLVNLEIFNNSTDGTTEGTLFKLMDRCVTSFGKRLFRQWICRPLANKERIVDRQRAIEHLRDNPDHLQKVISILTKIPDLERMLARIRAGSSKIADLISVLNHFEAIHSKLEEFEKKMEDFEQEQINGNYSGYPNLLRYITTIKESFKVEQDKIIPSKGLFKEFDECQKKIQQIEQSLEEHLTEQKTYFSCRNIEFKHMGKEIYQIEVPVSALNRAKLPKNYQLKSKTKAACRYHTPFIIETLPSLLEERDELEVLSKEVSKKIQANFSVYFNHFSKAVQRLAQLDCLLSLFKVSCQSGIQMCRPIFVSKIPTNNGGFLDVRDMRHPCIYSKAGDDFIPNDLSLNVENSPPSILVLTGPNMGGKSTLLRQACILVIMAQMGCFVSASSCEMSIVDRIFTRLGANDNILAGQSTFMVELQETCSVLKYATNRSLVILDELGRGTSTFDGYSIAYSVLNYITKNLKSLCIFATHYQSLAMEPSIRNEISTGYMTCQVDEEEKRVIFLYKLAKGICQKSYGLHVAAMAGLPKEIVAKAEKKSEQMEKESVLVSYIHGTIHRSEMVKKIITAFKNKDHSDLKILSDTLKKLDLNNNIPDQ
The following text describes a protein:
Function:
Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
Subcellular Localization:
Secreted.
Sequence:
MNFYKIFVFVALILAISIGQSEAGWLKKLGKRIERIGQHTRDATIQGLGIAQQAANVAATARG
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MEDENGLELSLGLGCGGSSAKSKGKSGSSSDTRTEEGDRGNKLVDDFKNFLHGNTQKQDSSTGSQRSDSVKPQEKFFNDLSKNNADADAPINLNNRGLWVSSANRSAETDEEKRSDLGNKRKLLFDDLNNQKKHERDAHHSDLHDKKSHISITTEDGSTAENEDVAESEVEGSTSRLASHHDDGSKQFVGVGGPPEATNEIRGFSDSSVVELQGQRRLSSSSENEFKQGNLNYGVPFSVQPVSIMNVHSFPIKESNSVGAPSTSGHPITGMVQVLPTSNGEQRPGNQSVNPGNLPVMFGYSPVQLPTLDKDNSWGLVSHLQQFHPSYPGRAPSNAEKQNDGLKISQAMQAIARNSTEVAQFDGRTLGRAKGDRKQLITEEGSSSHTEDDAKGSTMNFRPKDAPPERSTAETICFDFSAIKPGIGPAVKFGGCGSYPNLPWVSTTAPGPNGRTISGVTYKYSANQIRIVCACHGYHMSPEEFVRHASEENANPDAGNGLATFPNANPAASTQS
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGKLVKHCHTSLHSELVILFYAKNRFCISIDHLRPLKSHRTHGHYCLLNFSLRENKNYLIIVYLPIEGFSANHMCISHGTSFNIK
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised.
Miscellaneous:
MISCELLANEOUS: Present with 259 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The coiled-coil domain is required for assembly into the NuA4 complex.
Sequence:
MAPTISKRIKTLSVSRPIIYGNTAKKMGSVKPPNAPAEHTHLWTIFVRGPQNEDISYFIKKVVFKLHDTYPNPVRSIEAPPFELTETGWGEFDINIKVYFVEEANEKVLNFYHRLRLHPYANPVPNSDNGNEQNTTDHNSKDAEVSSVYFDEIVFNEPNEEFFKILMSRPGNLLPSNKTDDCVYSKQLEQEEIDRIEIGIEKVDKEIDELKQKLENLVKQEAINGS
The following text describes a protein:
Function:
PKA-activated nonselective cation channel. Discriminates poorly among cations but is more permeable to Ca(2+) ions than to monovalent cations (By similarity). Acts as a calcium-activated calcium permeable channel which may operate as a endoplasmic reticulum (ER) Ca(2+)-leak channel, reducing the loading of the ER Ca(2+) store. Regulates intracellular Ca2+ signals, ion channel activity, and cytokine release in the renal tissue. Plays an important role in olfaction, amplifying cAMP-evoked cyclic nucleotide-gated (CNG) channel currents in the olfactory sensory neurons (By similarity). Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.
Miscellaneous:
MISCELLANEOUS: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.
Sequence:
MQGEESLRILVEPEGDSFPLMEISTCETEASEQWDYVLVAQRHTQRDPRQARQQQFLEELRRKGFHIKVIRDQKQVFFGIRADNSVFGLYRTLLLEPEGPAPHAELAAPTTIPVTTSLRIRIVNFVVMNNKTSAGETFEDLMKDGVFEARFPLHKGEGRLKKTWARWRHMFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQISKEICEAHDILMCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIWKRQRARVVLHWDLYVWDEEQEEMALQLINCPDYKLRPYQHSYLRSTVILVLTLLMICLMIGMAHVLVVYRVLASALFSSSAVPFLEEQVTTAVVVTGALVHYVTIIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQTLSNCVEYLVPWVTHKCRSLRASESGHLPRDPELRDWRRNYLLNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHTKDFQDPDGIEGSENVTLCRYRDYRNPPDYNFSEQFWFLLAIRLAFVILFEHVALCIKLIAAWFVPDIPQSVKNKVLEVKYQRLREKMWHGRQRLGGVGAGSRPPMPAHPTPASIFSARSTDV
The following text describes a protein:
Function:
Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the preautophagosome (PAS), the site of vesicle/autophagosome formation. Required for atg9 anterograde transport from the mitochondria to the PAS (By similarity). Required for nitrogen starvation-induced sexual development and for entering the dormant G0 state (By similarity).
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.
Sequence:
MRFRLNDSFSGKSWTIDNVQWTPQNLVAWIMELNIGLSDEAKLLLPNGMSLNETVLNSESDVVIYVLDQNLLTFTYDGDKIPSIPSLKGQPISNVLTGIIADSSSDQWKDKISKCLSLLSDILESSSKIHNQLSVCHDEYSTSIVSPEVAMNYLQRRQSGMKDLLFVFYERLDRVSVSDLLHDFLALPTGSLPITPLKILSTNWTKLDSWLNSISARYAEAQKRVQQCIGAANSIIVSPFKEVPSIKEGDDAYYHLRSVAQDAANILQEILKIESTSTTSQIKPKCNYETEITDCMEKLQSNLSELKSSRKSSLISLKSFWLSFYKVSLRYDALYEYLRQIAEELDRSKFVLSQSRNIFSLYIDILMEALRRTEWQESYNVSHDSSLPLDQEKELSLRKSWLSHFSNLLFNHGQLKYLPVLTRDEISNYLLNIQAHPNYQTFHQMLSNRLSEYLGFPGSPREAVSNTVQANNSLHEKLAMYQNRCNNLEAMLSHQNGFNYNINNDGLSPNAPHPPINEQSNSSQPFYRVSPSIVPLNVIRKLTNRKTSFTDSHILRLQDEVNQLRNELDLVNKRNEDLLIELQGKEEKIQYLETENEEVLQKYENLQEELSSTRKLLTKNEAAVAEQQSNEEMHSNEPNILNLYSVFEGKVDSLQELYNAFKLQLTSLKQKGEYATLAKDAEAVQHIIEERDYALAEKADLLKLSENRKEQCKILTQKLYTIVFRCNELQSVLRECVTQPGFDSDNERDGHASIPDRQIEFNSKDLQYLYWMDGEDADRNFQEFLNRMSSLDFDSFHNFVVSVLTQAHNHELRWKREFQSNRDKALKAILDSQSKVSLRNFKQGSLVLFLPTRRTAGNKKVWAAFNVNAPHYYLNTQPHLKLESRDWMLGRVTSIEDRTADDSTDKWLRLPSGTIWHLVEAIDERF
The following text describes a protein:
Function:
Acts as a transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1-responsive promoters. Synergizes with YAP1 to enhance PGR activity (By similarity). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus when phosphorylated.
Domain:
The PPxY motif 1 mediates interaction with NEDD4. The PPxY motif 2 is required for the coactivation function (By similarity).
Sequence:
MALNKNHSEGGGVIVNNTESILMSYDHVELTFNDMKNVPEAFKGTKKGTVYLTPYRVIFLSKGKDAMQSFMMPFYLMKDCEIKQPVFGANFIKGIVKAEAGGGWEGSASYKLTFTAGGAIEFGQRMLQVASQASRGEVPNGAYGYPYMPSGAYVFPPPVANGMYPCPPGYPYPPPPPEFYPGPPMMDGAMGYVQPPPPPYPGPMEPPVSGPSAPATPAAEAKAAEAAASAYYNPGNPHNVYMPTSQPPPPPYYPPEDKKTQ
The following text describes a protein:
Function:
[Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the endoplasmic reticulum (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity); [Sonic hedgehog protein N-product]: The dually lipidated sonic hedgehog protein N-product (ShhNp) is a morphogen which is essential for a variety of patterning events during development. Induces ventral cell fate in the neural tube and somites. Involved in the patterning of the anterior-posterior axis of the developing limb bud (By similarity). Essential for axon guidance (By similarity). Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTCH1 represses the constitutive signaling activity of SMO.
Subcellular Localization:
[Sonic hedgehog protein]: Endoplasmic reticulum membrane. Golgi apparatus membrane. Secreted. Note=Co-localizes with HHAT in the ER and Golgi membrane; [Sonic hedgehog protein N-product]: Cell membrane; Lipid-anchor. Note=The dual-lipidated sonic hedgehog protein N-product (ShhNp) is firmly tethered to the cell membrane where it forms multimers. Further solubilization and release from the cell surface seem to be achieved through different mechanisms, including the interaction with DISP1 and SCUBE2, movement by lipoprotein particles, transport by cellular extensions called cytonemes or by the proteolytic removal of both terminal lipidated peptides.
Domain:
[Sonic hedgehog protein N-product]: Binds calcium and zinc ions; this stabilizes the protein fold and is essential for protein-protein interactions mediated by this domain; [Sonic hedgehog protein N-product]: The Cardin-Weintraub (CW) motif is required for heparan sulfate binding of the solubilized ShhNp. The N-terminal palmitoylated peptide is cleaved at the heparan sulfate-binding Cardin-Weintraub (CW) motif site. The cleavage reduced the interactions with heparan sulfate. The cleavage is enhanced by SCUBE2.
Sequence:
MLLLARCLLLVLVSSLLVCSGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLTFLDRDDGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSATGEPEASSGSGPPSGGALGPRALFASRVRPGQRVYVVAERDGDRRLLPAAVHSVTLSEEAAGAYAPLTAQGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDRGGDSGGGDRGGGGGRVALTAPGAADAPGAGATAGIHWYSQLLYQIGTWLLDSEALHPLGMAVKSS
The following text describes a protein:
Function:
Part of a cryptic operon that is poorly expressed in vivo. May be an ancestral sugar porin with a broad carbohydrate specificity; it binds aromatic beta-D-glucosides such as arbutin and salicin, but with low affinity compared to the binding of maltooligosaccharides to the LamB porin.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein. Note=Can be easily removed from the outer membrane by treatment with detergent.
Sequence:
MFRRNLITSAILLMAPLAFSAQSLAESLTVEQRLELLEKALRETQSELKKYKDEEKKKYTPATVNRSVSTNDQGYAANPFPTSSAAKPDAVLVKNEEKNASETGSIYSSMTLKDFSKFVKDEIGFSYNGYYRSGWGTASHGSPKSWAIGSLGRFGNEYSGWFDLQLKQRVYNENGKRVDAVVMMDGNVGQQYSTGWFGDNAGGENYMQFSDMYVTTKGFLPFAPEADFWVGKHGAPKIEIQMLDWKTQRTDAAAGVGLENWKVGPGKIDIALVREDVDDYDRSLQNKQQINTNTIDLRYKDIPLWDKATLMVSGRYVTANESASEKDNQDNNGYYDWKDTWMFGTSLTQKFDKGGFNEFSFLVANNSIASNFGRYAGASPFTTFNGRYYGDHTGGTAVRLTSQGEAYIGDHFIVANAIVYSFGNDIYSYETGAHSDFESIRAVVRPAYIWDQYNQTGVELGYFTQQNKDANSNKFNESGYKTTLFHTFKVNTSMLTSRPEIRFYATYIKALENELDGFTFEDNKDDQFAVGAQAEIWW
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MSTKIFPLVVTFLLSINVSSCWSTTINSLFKSKTILQFNQDLNPVIIESVANGAQMAMDECRNVFKWDRWNCPQSAFSRQNNHLATKEKAYTNAIITAGIIYSITRDCSQGVIKGCGCDPKLRKNIYQEAKTKNLERDWTWGGCSDDSSFGEELVLKLLEDNEESSDAQAFINRHNNRIGREIIREKMLKTCKCHGVSGSCSFQTCWMQMPTFPEIAKQLRERYDRAIMISFERVQGALTLGNSARHMPLESAGDVLPNLLYLEKSPDFCLSNNSTGWPGTRGRTCSRTTSASMAERKSCRNLCRSCGFRVRKQEKKVTKRCNCKFIWCCEVECDVCVEYVNEFTCH
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQAPDDGEGGAGTPSGQHSSQLPDCHSSSGSPEGEGGPGNEGAVIKAALATPRPDQAPPAQGPGGDAVRMAVGPGSGPLEFTLTVTLRSPLEADMARRSLIPDAQRHQHGIQREFTVNGSALAIRWTAADLALFRSSINSSLDQLCLVIRNIRRFVPPPAKSLREERGLRPNFVSPTRQCIGNSNLE