lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Sequence:
MTSQAVRVAVALSGGVDSAVAALFLCRCVSTWRDVEALWRSPRPLPLDTVMDAIVKRRAWADITQSSATTPMQQNPTTAVHYFPLFMKNWDDVSEDSDGSASDTCENVGGNHRRRWCEAAEQDYHDAAEVARFAGLLSESEALPLFNFSSHYVTSCFDRMLNSYARGNTLNVDVLCNSEIKFGALLHALHTSGRAQYVATGHYARTISLADTVFCSAAASESGNGRYTRVIARPFTAGQDLNDQTLFLSRLSQLQLSNVIFPLGHVFQRKADVRVVASHLGLTRVSAKKTSTGLCFVGERYKRKSGKGGGFGAFLTEYMASAPEESGGEGVHADEETKYLDAETEQIIAADQLNIPGIVRRQDRTLLPAHYLTVGQRIRGAAGNSGSPRCYYVQRKEVSPIHGYEKCGENCCIRYLRNVWLVNRWNHPLLYNTLVKLSDVVLPLRMTQLLMLSLAFPPSRSPRHGEEGEEVCLRCSCCTRHQDPLHPAVLRFRACEVQEFAGGTSVNFAVVEFDTPVRAATAGQTLVGYCPINPVTLSVSSAVHSASWYVVASGWII
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
Subcellular Localization:
Cytoplasm.
Sequence:
MAEMSNNKTSEEAKANGKKSQSETLEESKLENMNSEESTETTQTESMETAETETSLQTELESAKKEIESLKDSWARERAEFQNFKRRSAQEFVSIRKEAVKSLVSGFLNPIDNLERVGATQTNSEELKPFVDGVTMILKEFYSVLEKSNVIRFDPKGEPFDPMSMEALSSEEGDQYSEETVIDVYQPGYYYKENEDKFTLRPARVRIGKPKS
The following text describes a protein:
Function:
Transcription factor acting negatively in the phytochrome B signaling pathway under prolonged red light. Regulates PHYB abundance at the post-transcriptional level, possibly via the ubiquitin-proteasome pathway. May regulate the expression of a subset of genes by binding to the G-box motif.
Subcellular Localization:
Nucleus. Note=Migrates rapidly to speckles upon light exposure.
Domain:
The active phytochrome binding (APB) motif (3-17) is involved in interaction with PHYB; The Gln-rich domain in the C-terminal region functions to modulate the transcriptional activity of BHLH72/PIF7.
Sequence:
MSNYGVKELTWENGQLTVHGLGDEVEPTTSNNPIWTQSLNGCETLESVVHQAALQQPSKFQLQSPNGPNHNYESKDGSCSRKRGYPQEMDRWFAVQEESHRVGHSVTASASGTNMSWASFESGRSLKTARTGDRDYFRSGSETQDTEGDEQETRGEAGRSNGRRGRAAAIHNESERRRRDRINQRMRTLQKLLPTASKADKVSILDDVIEHLKQLQAQVQFMSLRANLPQQMMIPQLPPPQSVLSIQHQQQQQQQQQQQQQQQQQFQMSLLATMARMGMGGGGNGYGGLVPPPPPPPMMVPPMGNRDCTNGSSATLSDPYSAFFAQTMNMDLYNKMAAAIYRQQSDQTTKVNIGMPSSSSNHEKRD
The following text describes a protein:
Function:
Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MGSVNSSPNEEFETVPDSQISGFDSPLIPTSVGSYFRDDDDDEKVHPNFISDPENDSLNSDEEFSSLENSDLNLSGAKAESGDDFDPILKRTIISKRKAPSNNEDEEIVKTPRKLVNYVPLKIFNLGDSFDDTITTTVAKLQDLKKEILDSPRSNKSIVITSNTVAKSELQKSIKFSGSIPEIYLDVVTKETISDKYKDWHFISKNCHYEQLMDLEMKDTAYSFLFGSSRSQGKVPEFVHLKCPSITNLLVLFGVNQEKCNSLKINYEKKENSRYDNLCTIFPVNKMLKFLMYFYSDDDNDDVREFFLKAFICLILDRKVFNAMESDHRLCFKVLELFNEAHFINSYFEIVDKNDFFLHYRLLQIFPHLQSALLRRRFSEKQGRTETIQQNIIKEFNEFFDCKNYKNLLYFILTMYGSKFIPFGPKCQVTEYFKDCILDISNETTNDVEISILKGILNLFSKIR
The following text describes a protein:
Function:
Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (By similarity). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).
Miscellaneous:
MISCELLANEOUS: The postsynaptic actions of L-glutamate are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > L-glutamate > kainate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Postsynaptic density membrane; Multi-pass membrane protein. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression (By similarity). Displays a somatodendritic localization and is excluded from axons in neurons (By similarity).
Domain:
The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.
Sequence:
MQKIMHISVLLSPILWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNAQNINPSSSQNSQNFATYKEGYNVYGIESVKI
The following text describes a protein:
Function:
Putative gamma-glutamylcyclotransferase.
Sequence:
MTSSDKSLSHDVFVYGSFQEPSVVNLILECSPVMVPAQLHGYHVYRLKGRLHACISPSENGLINGKILTGLTDSQLENLDMIEGSEYVRKTVEVVLTDTSEKKQVETYVWANKDDPNLYGEWDFEEWRRLHMDKFIEASTKFIEWKKNPDGRSREEFEKFVFDDPPTAA
The following text describes a protein:
Function:
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
Sequence:
MNDNREQLTQQIIDAGRFLYGRGWSPATSSNYSARLDEQRALLTVSGKHKGQLGFDDVLATDLAGNSLEPGKKPSAETLLHTQLYAWNPAIGAVLHTHSVNATVLSRLVRGDRLVLQDYELQKAFAGVTTHEGQVEVPIFDNDQDIARLASRVQPWLEAHPHCPGYLIRGHGLYTWGARMSDALRQVEAFEFLFECELKVLSLSR
The following text describes a protein:
Function:
Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
Sequence:
MGVSAALGAQAPIALSVSGALGASSSLRRESVCSTSGSSCCSWKMSISSGIKVGVLEGSSDAALPCSNGIRAVASEPRAKKASAAGESDKDIKPQANPLSTNPSEIASNIKYHAEYTPSFSPYKFELKQAYVATAESLRDTLIERWNQTYKHFSKENAKTIHYLSMEFLQGRALLNAIGNLELNDAYSEALHKLGYDLEAVAEQEPDAALGNGGLGRLASCFLDSLSTLNYPAWGYGLRYKYGLFQQSITKDGQKEQCEKWLEMGYPWEIPRNDISYPIKFFGQVAEGQGGKREWVGGENVRAFAYDVPIPGFRTKNTISLRLWSTRVAAEDFDLAAFNSGDYSKAGEAHANAERICYVLYPGDATEEGKQLRLKQQYTLCSASIQDIMARFKERSKGALNWDALPSKVAIQMNDTHPTLCVPELLRILIDEEGLAWDEAWKITQATVAYTNHTVLPEALEKWPLTTFQKLLPRHVEIIETIDEQFMSFVAGNVEKSELESKIASMRILENVDLPASIQSLLPPKPVREKAKKVKPVTDAAIKENGTKSPVKEAAAEEEEEEEEEVVPPKPASTVRMANLCVIAGHKVNGVAAIHSQIVIDEVFNDFYQLWPEKFQNKTNGVTPRRWLKFCNPELSSVITKWLGSEEWVLDTKQLSGLRNFADNKELQQEWVNAKVARKAKLAAYIKSKTGYTINPNALFDIQVKRIHEYKRQLLNIMGVIYRYKKMKEMSEKERAAKYVPRVVMFGGKAFATYWQAKRIVKLITDVAATVNNDPEIGDLLKVIMVPDYNVSVAEVLIPASELSQHISTAGMEASGTSNMKFSMNGCVLIGTLDGANVEIREEVGEDNFFLFGAYAHEIAGLRADRAAGKFQPDPRFEEVKSFIRSGVFGDYDYNELLGSLEGDSGYGRGDYFLVGHDFPAYIECQDKVDEAYRDQQRWTRMSIMNTAGSYTFSSDRTIHEYAKDIWEITPSPLE
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
Sequence:
MQFTGKNVLITGASKGIGAEIAKTLASMGLKVWINYRSNAEVADALKNELEEKGYKAAVIKFDAASESDFIEAIQTIVQSDGGLSYLVNNAGVVRDKLAIKMKTEDFHHVIDNNLTSAFIGCREALKVMSKSRFGSVVNVASIIGERGNMGQTNYSASKGGMIAMSKSFAYEGALRNIRFNSVTPGFIETDMNANLKDELKADYVKNIPLNRLGSAKEVAEAVAFLLSDHSSYITGETLKVNGGLYM
The following text describes a protein:
Function:
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.
Subcellular Localization:
Nucleus.
Sequence:
MVFLREGLCPGLTEEVIQALRTQEIRTVEDLVSSELEELAQKCSISYKALVAIRRVLLTQHTGFPVSGADLYEELLSSMAILSTGNESLDVLLDAGLYTGEVTELAGGPGSGKTQVCLGVAVNISCVLKRTVLYIDTNGGLSASRLLQMVQSKTSNMEEQVEALNRILVCRVFDVFSLLETLHSLRSGGLEQASVRNGPIRAVLVDSVTAVLSHMLGGRQTEGMSLMMQVAGALRLIAKDLNVAVLVTNHVTRDGNGVLKAGLGQSWSHVPRTRVLLQRVDGPQARHSGLRWATLLKSSRQPCHQKQQFDLGSGGQPADSHPDHLQRREQEDVFKH
The following text describes a protein:
Function:
Plays an important role in membrane trafficking through the secretory apparatus.
Sequence:
MEVGGDTAAPAPGGAEDLEDTEDTQFPSEEAREGGGIHAVPPDPEDEGLEETGSKDKDQPPSPSPPPQSEALSSTSRLWSPAAPENSPTRSPESSSGGQGGDPSDEEWRSQRKHVFVLSEAGKPIYSRYGSVEALSATMGVMTALVSFVQSAGDAIRAIYAEDHKLVFLQQGPLLLVAMSRTSQSAAQLRGELLAVHAQIVSTLTRASVARIFAHKQNYDLRRLLAGSERTLDRLLDSMEQDPGALLLGAVRCVPLARPLRDALGALLRRCTAPGLALSVLAVGGRLITAAQERNVLAECRLDPADLQLLLDWVGAPAFAAGEAWAPVCLPRFNPDGFFYAYVARLDAMPVCLLLLGTQREAFHAMAACRRLVEDGMHALGAMRALGEAGSFSNASSASAPAYSVQAVGAPGLRHFLYKPLDIPDHHRQLPQFTSPELEAPYSREEERQRLSDLYHRLHARLHSTSRPLRLIYHVAEKETLLAWVTSKFELYTCLSPLVTKAGAILVVTKLLRWVKKEEDRLFIRYPPKYSTPPATSTDQAAHNGLFTGL
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Subcellular Localization:
Cytoplasm.
Sequence:
MECQRCSASARNPATVESRKEKFCDECFIKFVSTKQRKQMMKDEYFRNLFKVIYPFEKEGSVSKILLPLSLSDSGSLVMLDIVHDLLLEQTKQHNNRTGFTVDVLTVFTEENVSVIKERMESLINEKMSQLNKISNIFNVHFIDVNEFFNNASEVSTFIIDNENFEIFSKSKSVDDSNILTLKEILGKYCLNSSSRSDLISIIKTQLIKHFAYENGYNAIMWGHSMTKLSEVIISLVVKGKGSQIATFLDSESFDTLNNKPCKYKNLYPMKDLLSVEIESFLQIRNLAQFLINVEETNVKPNCLIARKSLPSLGQQKLVKNMTINEITNKYFQDIQNDYSNIISTVLRTADKLTQPKSSMAKPSQCQICQSKIYTNPSNWLNRITVTSPYPVETTEEKYLFKQWQDSKLGQSHTHYVELLNEIKQGASNSLDVEDSDVKLCYGCLILLNTSIKDKNLVWPKVDTMDITANATNKNKELSQILDQFEINSDGEE
The following text describes a protein:
Function:
Probable xylan acetyltransferase required for 2-O- and 3-O-monoacetylation of xylosyl residues in xylan. Possesses extremely low activity in vitro.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MKAPPPPSPVAKRARVSPFVFLLVLFLLLFSFLYGEDLKELLGSQAQARPSLHFNAAAAGDGIELPAATAATTEGRTTTRRWRGRLPFAANGDGEEEEEECDVFSGRWVRDEAARPLYREADCPYIPAQLACEAHGRPETAYQRWRWQPRGCALPAFDAAAMLDRLRGKRVMFVGDSLGRGQFTSLVCLLLAAVPDPAARSFATSPDQQRSVFTAAAYNATVEFYWAPFLLQSNADNAAVHRISDRMVRRGSIGHHGRHWEGADVIVFNTYLWWCTGLQFRILEDGPFDAGGNSSTTTWVSTEEAYAMAFREMLQWAREHMDFATTRVFFTSMSPTHGKSQDWGGGEPGGNCYGETEMIGDAAYWGSDSRRGVMRAIGEVLDGDGADVPVTFLNVTQLSLYRKDAHTSVYKKQWTPPTPEQLADPKTYADCVHWCLPGLQDTWNELLYTKLFYP
The following text describes a protein:
Function:
Interacts with OSBPL11 to function as lipid transfer proteins. Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex.
Sequence:
MAVSMEGPLSKWTNVMKGWQYRWFVLDDSTGLLSYYTSKDKMMRGARRGCVRLKGAVIGIDDEDDSTFTINCDGKTFHFQARDADERERWISALEDTITRHSQSPSVGYDFPTSVTSHPITTTADFDTKLMEADAYLQILIKQTKALEARTDACEDEDEKKRLQSLVDVSNAMLESIKHSIVLMQVAKYACVEHMDSGRLTTMNGVPGTEDISTGDQLSNSGSGSTASLEQATEAIEEGGGQMTDYGQGLDGLVEAGTQTNGSNAPSLLPVDTSTQTGSHTSSPISGPVVTLALQVPVLPQTSYSSSEDEDFFDADEFYQASPEKSPSRMPNSFQDSLSRNDLVKKLDQDFQEEEKENIPEVSVTGATPGKENPDVMMRGGICIVTDSSGSEEESTENMENHQSVITHLLSQVKLGMDLTKVVLPTFILEKRSLLEMYADFFAHPDLFSSIPDFEDPKDRMIGVIRWYLSAFHAGRKGSVAKKPYNPILGETLRCFWDLGTDNLDGEQELVTDGPIPWATRDNVTFIAEQVSHHPPISAFYAEHYNKNISFNAHIWTKSKFLGLSIGVHNIGQGCVWVRKYDEEYIVTFPNGYGRSILTIPWMELGGKVTITCAKSGYSCNIDFLTKPFYGGSKHKIKADVMGPSEKKPFCVIEGEWNGVMYAKWATGQEEVFVDTKKMKIMKKKVQKLEDQGEYESRKLWNRVTEALSSRNIDSATEAKQFLEERQRREARERKEAGVKWETKLFHEDGEQWIYDNPLQKRLELQDKLQ
The following text describes a protein:
Function:
Required for normal assembly of the mitotic spindle. May be involved in both centrosome-dependent and centrosome-independent spindle assembly programs.
Subcellular Localization:
Nucleus, nucleolus. Note=Found in the nucleolus during interphase.
Sequence:
MSLLRIRKPKTRKGKKVLLAREPQLIESARTMLFLDGRKCGGNVKLCMKDLQALKKPLVKVLNRKNDITPFDDPSSLEFLTMKNDAALFTFGSTSKKRPDNIILGRIFENEVLDMFELGIKRYQAISEFKNEKIGACVKPCLVFNGPKWAQTEELRRLRNLFIDTFQREKVDSIRLQGIEHVLSFTVTDDMNILMRSYRILLKKSGQRTPRIELEEIGPSADFSIRRTKIASEDLYKQARKQPKQLKVGKKKNISTDALGNTKGRVHLGKQQTGSIQTRRVKALRKTPEEKKENRQRKKVALKAAAAEALASQGNNPFSS
The following text describes a protein:
Function:
Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
Miscellaneous:
MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2A).
Subcellular Localization:
Cytoplasm.
Sequence:
MNFLKFTEDKLSVEALTDLVASPKCGAVSVFMGTTRDSFGEKTVLKLEYEAYEAMALKCLEKVCGEIRAKWPQVENIAIYHRLGVVGVKEASIVIAIASPHRTEALQATDWCINKVKESVPIWKKEIYAETETPPQWKENKESPKPKKFKLEIEPKVEIPNVSPHLIQIKASNADLSKRIENFMEMKRNEINISNVREFCTSNRSSEFTCARVDAVLQKRKDSNGHLQVSRVLNTYHRDQTNSDYLTKYIPQNGIEERLQNLEIQLSLTTPTPKNIYTRLKKLEDRILFLETISPEYINFWVSFLRDFPPFLVKFLGQKPLKQ
The following text describes a protein:
Function:
Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane.
Miscellaneous:
MISCELLANEOUS: Present with 195 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLRVSENGLRFLLKCHSTNVSMFNRLLSTQIKEGRSSIDDAGIIPDGTINERPNHYIEGITKGSDLDLLEKGIRKTDEMTSNFTNYMYKFHRLPPNYGSNQLITIDKELQKELDGVMSSFKAPCRFVFGYGSGVFEQAGYSKSHSKPQIDIILGVTYPSHFHSINMRQNPQHYSSLKYFGSEFVSKFQQIGAGVYFNPFANINGHDVKYGVVSMETLLKDIATWNTFYLAGRLQKPVKILKNDLRVQYWNQLNLKAAATLAKHYTLEKNNNKFDEFQFYKEITALSYAGDIRYKLGGENPDKVNNIVTKNFERFQEYYKPIYKEVVLNDSFYLPKGFTLKNTQRLLLSRISKSSALQTIKGVFTAGITKSIKYAWAKKLKSMRRS
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MPTAIFKTNFGNFSVYLDEEKAPITAGNFIKLAKDGFYNGLTFHRVIKNFMIQGGCPVGNGTGGPGYKIQDEFHKDLKNEKFTLSMANAGPNTGGSQFFINVRDNFYLDNRHAVFGRVTEGMDIVETISETETGFQDKPTKSVIIETITVSP
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs. Binds the APUM-binding elements (APBEs) in the 3'-UTR mRNA sequence of CLV1, PNH, WUS and FAS2.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTESPIRMLESDDSKKWLPTVDSGLFSSPLPSRSGSAPPTIEGSIAAFQAFMDQRNSTLTSSNNEFLDCESEEQMRTDPAYIAYYYANVNLNPRLPPPLISRGSRHLVQFMGGFGSKKTEGLLATHKEEPEESVSPQQSSGDPEGSFVHGKKMTTLADLKEESPSSVSADVHSTMNSSTSPVLTPSNCRNVEPEDNSSIQSNIGSDNSVVESRMKLLDVSGELLREDDQKRRDYHLRLIEENRLLPHHPSQGTAYQLPGFHSYTVPRGMFSVHQKLLPVHQSFMHSTGLVPVPVPPLYTSTAANYMNSGNLFYPSVPLPVFPTPQSAHFGGFLQDSAFPFPIDAYSKASFFKQQMEALHGGLNPYTSQVLRPSFGSPVQGQSFQQFQLDSLASRKDTVAGSSVGDKELNHLANKQNITSGTHLRFPAHSLAEPQFAVPSALPGSSVTRNINQGLGNDLSGSSQHSSKSTVAYPGWKEQRGSESSENNTNSKRQAFLELLKSFSTRMLELSDISGQIVEFSTDQHGSRFIQQKLESCGSKEKESVFEEVLPQASKLMTDVFGNYVVQKFFEHGTVEQRRKLGQKLTGQVLTLSLQMYGCRVIQKALEVIELDQKVELMKELDGNVMRCVHDQNGNHVIQKCIESVPTEKLKFIVSSFTGQVATLSCHPYGCRVIQRVLEHCSDLEISQWIVDEILDSTSALAHDPYGNYVTQHVMEMGKPYQRSQIIHKLTGRFVQLSQHKFASNVVEKCIIYGNDSERDLIIEEIITQSDNNESLLMMMKDQYANYVIQKIFEIGSEKQKDILQNCIRLHLPALKKVTYAKHIVSRYEQLAAEGSEQGKEQFVKLSDNNPSNSG
The following text describes a protein:
Function:
Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism.
Sequence:
MVRMSEYIHTSVSNGTGLIVLDRPKALNSLSLDMVRAITRALLDWRDDERVAAVLVRSSSEKAFCAGGDIRFFYEAGRSTPQGGSALVEDFFTEEYSLNHLIHFYPKPYIALMDGVVMGGGMGIAQGGVRLVTDKTKMAMPEVNIGLFPDVGGSYFLSRALGALGFYLGVTGVTIGAADALYAGLADHYVPLSDRAALDGLLAAMSGAQLRDAIARYADAHDAGASALAVDRAAIDLHFSAGSVPAIVASLQADGGEFAARTLEVMATRSPLMMSVTHELIKRGAALDVAGCLRMERALVRRNFENGEVIEGVRALVIDKDNQPRWNPATLTDVTEEMVQAMFEPVWPDYAHPLRHL
The following text describes a protein:
Function:
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Sequence:
MTLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRGDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRKK
The following text describes a protein:
Function:
The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis. Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MADSAETQELVYLVTGGCGFLGEHVVRMLLQREPRLRELRIFDLHLGPWLEELKTGPVQVTAIQGDVTQAHEVAAAVAGAHVVIHTAGLVDVFGKTSPETIHEVNVQGTQNVIEACVQTGTRFLIYTSSMEVVGPNIKGQPFYRGNENTPYEAVHRHPYPCSKALAEQLVLEANGREVLGGLPLVTCALRPTGIYGEGHQIMRDFYHQGLRLGGRLFRAIPASVEHGRVYVGNVAWMHVLVARELEHRAALMGGQVYFCYDNSPYKSYEDFNMEFLGPCGLRLVGTRPLMPYWLLVLLAALNTLLQWLLRPLMLYAPLLNPYTLAVANTTFTVSTDKARRHFGYEPLFSWEESRTRTIRWVQTVEGSA
The following text describes a protein:
Function:
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
Subcellular Localization:
Cytoplasm.
Sequence:
MTSQSLRDQAATFGLTTEEYDLFVSQLGREPNALEAAIVGAMWSEHCGYKNSRPLFRAFPTTGPQVLQGPGENAGVVDIGDGWGVAFKMESHNHPSAVEPVQGAATGVGGILRDIFAMGARPFAVLDSLRFGNPDSPRTRFLVNGVVDGIAHYGNAIGVPTVGGEVTFHPSYQENPLVNVMALGLLRHEDLATGTMGEVGNQIVYVGSKTGRDGLGGAVFSSADLSAASQADRPAVQVGDPFMEKLLLEATLEAIQAGLVAGVQDMGAAGLVSSTCEMAYRASLGITMDLDKVPTREEGMVPMELCLSESQERMILVPVPGKEQALHDLLAKWELDVVTIGEVEAHDRYRLTWKGEVVCDLPVALLNEAPKYTREGVESADIRAARERDLSGVPLPGDLGAVLLELLSHPTIASKRPIFERYDHQVMTNTVVVPGAADAAVLRVKGSPMGVAATSDCNPRFVQLDPYAGAAAAVAEAARNLACVGATPLAITDNLNFGNPHRPEVYYQLQQAVQGIADACRALNTPVTGGNVSLYNQYTEGDHKVAIHPTPTIGMVGVLPDVTVRASLNLKAAGQTLLLLGHRAEKGWSDSIGASQYLETVHGLEAGQVPPVDLDLAQKVVDGTLALIRAGLTDTAHDCAEGGLAVALAEMAIAGGLGLNVSLDAPASVRADALLFGEAHSRVIVAVEDAAAAGAKLDELGLPYAVLGETVEAPKVTIAAPAQHVHLSVNLESLKTAWEEPLKGILG
The following text describes a protein:
Function:
Functions as an E3 ubiquitin ligase.
Sequence:
MDNRIVISNCGAISLIVDLLQSTDTTIQEHSVTTLLNLSINDNNKAAIANAGAIEPLIHVLQIGSPEAKENSAATLFSLSVTEENKIRIGRAGAIRPLVDLLGNGTPRGKKDAATALFNLSLFHENKDRIVQAGAVKNLVDLMDLAAGMVDKVVAVLANLATIPEGKTAIGQQGGIPVLVEVIESGSARGKENAAAALLHLCSDNHRYLNMVLQEGAVPPLVALSQSGKGQRKGLGSP
The following text describes a protein:
Function:
Heme-binding protein.
Subcellular Localization:
Secreted.
Domain:
The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residues at position 99 and 126.
Sequence:
MFGLLRHLFKFQFLFVVAAVLGGIYHTEIRQFLRRQTDNYLDQAGQDASIPLAFQAGDDIGTLFTPAELAKFNGEEEGRPLYLALLGSVFDVSRGIKHYGSGCSYNFFVGRDASVSFISGDFETYDPETADDVLTLKPDDLIGLAGWRDFYQKDYVYKGRVIGRFYDEKGALTTYHHKFLELLEQARDAKRQVEELRARYPGCNIEWSEERGTRVWCTTTSGDGKERSWIGYPRKLYSRGNKSFQCACVPDAELDEIDAGGKVAHGDAMLKPYDNCEPQARECFYRV
The following text describes a protein:
Function:
Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.
Subcellular Localization:
Cytoplasm, cytosol. Endoplasmic reticulum. Golgi apparatus. Mitochondrion.
Sequence:
MYQTLQRKRDDDQVCLNHNLQLLLIGRSASGKSITGNIMFNDSVFESRISSSSVTRVSQTHTASVNNRSVMVVDTPDFRFSTHTDFDSDSELKRALQLCVSGAHVILLFLSLSTFTEQDQEFIHWFEQKFGAEALRFTLVLFTHADKPHMRTLAEMIRRNTQLSDFINRCGRRYHEFNIKAPANRRQVTELMEKVERLVSENSHSCYTLEMMEDEEKRRKEKERREREEKERERQITLERVRQETEIRVRREYEEAKQWQEEEKKKERERQITLERVRQQAEIRVRREYEEEKQRRENRDSEYVREYGTKKESCILN
The following text describes a protein:
Function:
Essential for membrane formation.
Subcellular Localization:
Virion membrane; Single-pass membrane protein.
Sequence:
MPFPLVKQDPTSKAFTEASERSTGTQILDVVKAPIGLFGDDAKHEFVTRQEQAVSVVSWAVAAGLIGELIGYRGARSGRKAILANIPFLA
The following text describes a protein:
Function:
Has a role in the initiation of DNA replication. Required at S-phase checkpoint.
Subcellular Localization:
Nucleus.
Sequence:
MDIAHVKASVKAWEKAFKAEHGREPTKEDIKNDTSDIAEQYALYRKLSKSAASHGKPGESSKSSKQALSQQQQPQPRVTPRTIPTSAYPTTPTPPSRRSYTSLSRPNGSQSMQNLTAGPSSNAESSANGKPSHTQSLKRKASHAKLSPPPSALESSSAARTLFTTPKKKAYSGPIIDPNPVNPFNILNSPGKARSITNGGFNPNSGTGLSGVERMGSGAGAAGSKEAVSPFIHASSPKKLKQVLEANSYHKTLVSGPVTTVGCKVSERITPRTKARKRLRGEPVEDTPMKDRQVRRRRSHMAVSKSQSQSQLDSTRDVNFGKPLGSVFGDQNRDPMDEGQEDEEEGDEDEDEEGLGPSPVKPLGGKTFTSLFDDEDMPPRSIVSAKAKAPGGKMDGKGKSGKGASQPGIMGFFGKLKKAKEKEKEKEKEKEKEADVSTTPSLALDKSADNTLNSDIPSPTSFNPDIDLPELSAPSSAPHLGRKDKILSLSEDEDDEWDPEGGKVQQKVVIVPTRRQVKRRTSIDGLSGLLDGVEKGMVDEGQDEEVEEEGDVIFENGNGDTDGQSPHIPLDLLAITSPHKQRSAELESLRVSAIFNPFARKRLLALKRGQEIHTTGEAAIGGEEGDVDGWEGLDNVLEGEGKKDDDWESEDEGWKKIEEGLDDW