lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. Mediates cell-cell interactions and cell adhesion via the interaction with integrin alpha-IIb/beta3 (ITGA2B:ITGB3) and integrin alpha-V/beta-3 (ITGAV:ITGB3) (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The C-type lectin domain is required for binding to integrins (By similarity). Binding to soluble integrins alpha-V/beta-3 (ITGAV:ITGB3) and alpha-IIb/beta3 (ITGA2B:ITGB) is cation-dependent (By similarity). Binds to the allosteric site (site 2) of integrins and activates them (By similarity). The interaction with integrins may mediate cell-cell interactions and cell adhesion (By similarity).
Sequence:
MAGCPKGSWKPRLRSVVLGAAQLIWLSALISELVNRKKVATWTYNYSTKAYSWNNSRAFCKRHFTDLVAIQNKNEIAHLNDVIPYVNSYYWIGIRKINNKWTWVGTNKTLTAEAENWADNEPNNKRNNQDCVEIYIKSNSAPGKWNDEPCFKRKRALCYTASCQDMSCNSQGERIETIGSYTCSCYPGFYGPECEYVQECGKFDIPQHVLMNCSHPLGDFSFSSQCTFSCPEGYDLNGPSEMQCLASGIWTNNPPQCKAVQCQSLEAPLHGTMDCTHPLAAFAYDSSCKFECQPGYRMRGSDILHCTDSGQWSEPLPTCEAIACEPLESPLHGSMDCFPSTGAFGYNSSCTFRCTEGFVLMGNDAIHCADLGQWTAPAPVCEALQCQEFPVPSKAQVSCSDPFGPLKYQSACSFSCDEGSLLVGASVIRCLATGHWSEAPPECQAVSCTPLLSPENGTMTCIQPLGHSNYKSTCQFMCDEGFYLSGPERLDCSPSGHWTGSPPMCEAIKCPEIFAPEQGSLDCSHVHGEFSVGSTCHFSCNEEFELLGSRNVECTVSGRWSAPPPTCKGVTSLPVPSVRCPALTTPGQGTMSCRHHLESFGPNTTCYFGCKTGFTLRGANSLRCGASGQWTAVTPVCRAVKCSELHMDTAVAMNCSNPWGNFSYGSTCAFHCPEGQSLNGSARTTCGEDGHWSDAMPTCQAGTLTIQEALTYLGGALASTSGLAVGGTLLALLRKRLRKKDDGKCPLNPHSHLGTYGVFTNAAYDPTP
The following text describes a protein:
Function:
Benzophenone C-glycosyltransferase involved in the biosynthesis of mangiferin. Exhibits a robust regio- and stereospecific C-glycosylation activity toward over 35 substrates from 18 structurally different types with UDP-glucose. Also able to produce O- and N-glycosides and to use UDP-xylose as sugar donor. Generates only C-glycosides with 2,4,6-tri-hydroxy acceptors at the A ring, both C- and O- glycosides with 2,4-di-hydroxyl acceptors at the A ring, and only O-glycosides with 2- or 4-mono-hydroxy acceptors at the A ring.
Sequence:
MSASDALNSCPHVALLLSSGMGHLTPCLRFAATLVQHHCRVTIITNYPTVSVAESRAISLLLSDFPQITEKQFHLLPFDPSTANTTDPFFLRWEAIRRSAHLLNPLLSSISPPLSALVIDSSLVSSFVPVAANLDLPSYVLFTSSTRMCSLEETFPAFVASKTNFDSIQLDDVIEIPGFSPVPVSSVPPVFLNLNHLFTTMLIQNGQSFRKANGILINTFEALEGGILPGINDKRAADGLPPYCSVGPLLPCKFEKTECSAPVKWLDDQPEGSVVYVSFGSRFALSSEQIKELGDGLIRSGCRFLWVVKCKKVDQEDEESLDELLGRDVLEKIKKYGFVIKNWVNQQEILDHRAVGGFVTHGGWNSSMEAVWHGVPMLVWPQFGDQKINAEVIERSGLGMWVKRWGWGTQQLVKGEEIGERIKDLMGNNPLRVRAKTLREEARKAIEVGGSSEKTLKELIENWKKTSRKT
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MLEHFCECYSDLSGPIPCPVLGSITPLFIPNSRIRPIRLIGLCASLITFLYPPVPRIQFDPSTATSQFVESLRWLPYENINLYLGIDGISLFFVILTTFLIPICISVGWSGMRSYGKEYITASLIREFLMIAVFRMLDPLLFYVLPESVPIPMFIIIGVWGSRQRKIKAAYQFFLYTLLGSVFMLLAILLILLQTGTTDSQISLTTEFSERRQIFLWIASFASFAVKVPMVPVHIWLPEAHVEAPTAGSVILAGIPLKLGTHGFLRFSIPMFPEATLRSTPFIYTPSAIAIIYTSSTTSRQIDLKKIIAYSPVAHMNLVTIGMFSPNIQGIGGSILPMSSHGPVPSALFLCVGVLYDRHKTRLARYYGGSVSTMPNLPTISFSSTLANMSSPGTSSFIGEFPISVGAFQRNSLVATLAALGMILGAAYSLWLYNRAVSGNLKPDFLHKFSDPNGREVSIFIPFLVGVVRMGVHPKVFPDRMHTSVSNLVQHGKFN
The following text describes a protein:
Function:
May acetylate histones H2A and H3.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLTFNLNAISSSFSVVPFHANYPLSTQTQLLVPSNLSYSFATTGTRKFKSFQLKAGFWESIKSGLMKNNSMQVIDPPSADEEDEEPLPQEFVLVEKTEPDGTIEQIIFSSGGDVDVYDLQALCDKGWPRRPLSKLAAALKNSYIVASLHSIRKSPGSEGNEQKRLIGMARATSDHAFNATIWDVLVDPGYQGQGLGKALIEKLIRTLLQRDIGNITLFADSQVVEFYRNLGFEADPEGIKGMFWYPNH
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MEMEQLTFRDVAVDFSPDEWECLDPPQQRLYRDVMVENYRNLVSVALSHHCTQNFSPEQILKYSFTEVTNGSYSLQHLYLREDCANVGGNKAAACHGRHKQCLITSNTKDNRNQEQKTALKKPHARTDTFDEPCVYNCKYPQEIFQHDLTLKESWEDLIDRLIFHSSNFIDKELRNRGPISKSDQVESSYPGRAILFSQQIPVSCGQKHNTNDCGLPATDPLLHSQNLDTDIWETPYMYKEISKGFSSGSLLNSCNDVVILEKSGQRDKVQNDFDHCLSPNNHQCNLPKKLFNCDNFFTQCSKLTIQQCNYIQDNHYKSIDCDTMFNKTLNVTRRKIQHSKKSYKCNECGKAFKYCSSYRKHSIIHTGEKPYKCKLCGKSFTQCASLKKHQRIHTGEKPYRCEECGRSFNHYSILGQHQRIHTGEKPYKCKQCGKSFTQCSSLQKHQVIHTGEKPYRCAECGKSFTQNSTLSQHQRIHTGEKPYKCEECGKAFTQCSSLRKHQRIHTGEKPYKCEVCGRAFNCRSSFTKHKRIHTGEKPYKCKDCDKAFIHCTNLIQHQRIHTGEKPYKCNECGKSFSQCSNLRKHERIHT
The following text describes a protein:
Function:
Tiptop (tio) and teashirt (tsh) have, on the whole, common activities. Tio and tsh repress each other's expression and tsh has a crucial role for trunk patterning that is in part masked by ectopic expression of tiptop. Both genes share a common activity required for the activation of Ser and svb and the maintenance of en and wg.
Miscellaneous:
MISCELLANEOUS: The tsh tio gene pair seems to have arisen from a recent duplication event: tsh has the dominant role compared to tio.
Subcellular Localization:
Nucleus.
Sequence:
MMLHEAVMLEIYRQALSASELTSPRCQSRDSNTSAGAGAGMADVRCPSNESHCSANDRLTPAATPTLTPTEATISPNSVGLPLTATLPPAAAVALLPPQSAAMAAYLAAAQQNHLLLTNPLAAAASLVQHATQQAVVEGEVESPALDFSRKRPKSHGDDDQEEDQEQDQEQEQEQEPDHDVQCDNGPLDLSVSTGKRQESVSPPARKIPRSISADYKSPLPPGSWMPPINPYLAAVAAKTGGLGYSKLAPSEASKALEKMTEMSRLETSPTAARSLGATSSVGAGVPAGASSNSGGRHSAWQSHWLNKGADTAKDVFKCVWCKQSFSTLANLTAHMKETQHCGVQIPSPLPTGGVGTPSAPPPTRLATSASNSACSSSSSSTSSSSNSSKSELNMLIKETMPLPRKLVRGQDVWLGKGAEQTRQILKCMWCGQSFRSLAEMTSHMQETQHYTNIISQEQIISWKSGDERERPTNTGVPSTSTAAPSSPSCTAPSVSAVLTCKVCDQAFGSLKELSTHMAQKSHYKESPAPSASPPAAGTGNPKRGRQNRNEKRKKSLPVRKLLELERSGSNSSLDSALKPLRDFAAATKITCEKCGSKIETALFVEHIRKCLGESIPIPPRRSNAGVDRLPSPSLGLGAEKPPSVLNALEQLIEKSFESRTSRTMTHGGYSEAGTPLGASILKRLGIEDSSDYTKPLMDAQAMHLLRSSFASRDRSASESSSASRVESSYTPDRQQATPHKSPDTPAPPPPPPPTIKAEPLEAEPLVGCDREGCSPRQQIQVKKEFSMEACRESPRSVSKSPAPQTERSPPDNGSLLALNSMFDQLSGVENSGNNNSGHCFNNNNSCSSVSAQKPKAHPLAALQKLCETTDPPSTGLRSASSAGSSTASATLPSANGNDLVAFSWACNEAVLSASNGGSAGDSSIIKCSYCDTPFASKGAYRHHLSKVHFVKDAGEDSPRLKSPAVQSPRSMPLASPRRSASRSPATGSQQPPPSPTISPYDESPQSKFLKYTELAKQLSSKNA
The following text describes a protein:
Function:
Forms chloride channels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane.
Sequence:
MQKHSNKDVNVNIGIEAEESIQIEGVSATATKFGESLRGIFRWRQSFFKLVWKQAIIYYLIYVSITLFYAFALDTGGQANFDAVASYLARYTSSLPVVLLLGFFTSTALNRWFNIMSSMPGTNRAITLFVVSLKDDVADGRARVDLYIRYVLLMWLLTFRIVCQPLRRRYPNLMAIQNAGLLCENERLLLEKHKGQPGGTSRTCSLVVYDWLNALLRETSQKGYFLVANDFGRNIDAIQALKKGGGTVIKFATKNIPVALIQAVTIAIYCYGLVSILSHQIAEKHYLTSVMSGYFPLPYALPFFFYYAWLKVGRIATDPFGNDEDDINMLNVFEGHINGAVRLRNSYGIKIPTSTTEDNPFFLT
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MTPEEHQATASTPATSKRINLSASYIPNQNPIGSLISKVNPYLGPKKERKILVGTPLLTHTPSQAPLPTIPVTLQTDILLQSPEPPQIPGGRVGYNPELRSILSKHEESLQRLIDRYSRHKLHLSHQLNVDLAELEHQQTKSKCKLALIQKELTETVESNEKLNNKLLRFNFKLIDMNTYDRVFYIELDLAESDYRIVLMDPPCTHEGKSIGILIAMLVWSAHHVIGPPAPAPQYLDRPDPIDDAFEHLEKFCQPRPQAFSVWLYIHYKCWVSKHLQISCGNVSKYAPAGADVLDLGPGAFRNAMPKGASGPGALAKKVMGS
The following text describes a protein:
Function:
[Isoform a]: Probable dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Negatively regulates p38 MAPK signaling to allow for the plasma membrane of body wall muscle cells to form projections, also called muscle arms, that extend and connect the body wall muscles to target motor neurons. Negative regulation of p38 MAPK signaling may in turn modulate the trafficking of the muscle specific receptor eva-1 to the lysosome, to ensure proper display of the eva-1 receptor on the plasma membrane of muscle cells and allow for muscle arm extension towards guidance cues.
Subcellular Localization:
[Isoform a]: Cytoplasm. Nucleus. Note=Enriched in the cytoplasm.
Sequence:
MPILHQKIASTGGQPSTNSLALRRLPLVVIPRKRKYKNYVSRRRNTQLLASLRRCVSDPNVYKSYNHWKALLRPMTPIKSGAPTPKTVTPMPVPQIPPHQKMTPNPTPTQNPVQLPLPHAVSEKPGDKKSTGPTPSPVPSKAPISAAKLPGTVTKVAPLLSAAQPPPKTLAPAPGASETNSGSGPVSKQVSGKLTELKSKNGTVTEKTEKAVLRIPSSASTRAKAASAVAPEANPAPVPTATKPSPFAPAIAPLRDGAPAQPPAPIQASAPLRPPVAKQNSLQKPPEPKRSVGAPPKALPSELVNKIDGIEFLPQSSNQNTDDGQQPTTSTGGAKALRRAYGSKSGTTICAIGSPNVPSTSQPQQGDNEKRLIEKKLSLRKKKLSGEGVPPAGSMLTGSKSGVEIGLSSNLTTTNNNNNKEQTDEQRAKKTVNAVAAAFSTQAGSGNATTVDDPASTTTSKENPAAQPPKPKSAAVQNLISQLQLPASVSAKVDKIIACGDKARKPSRSGLQASQARPKVPEIVSSQRTQHQDDKDGHLIYSKGDFILNRFTIYDTLGEGTFGKVVRVNDSLSDTFMALKIIKNVSKYREAAKLEVKVLQKLAEKDPEKKNWVIHMGSYFDYNGHICLLFDLMGSSIFDFLKANHYKPYPMEQTLHITWQLCNAVKFLHDNKLTHTDLKPENILFVDSRYTTKLVDKKPLRVLHSTHVRLIDFGSATFDHEHHSIIVSTRHYRAPEVILELGWSQPCDVWSIGCILYELYTGVTLFQTHENREHLAMMERVLGDIPLRMAKRTKTKFFINGRLDWVNTSADAAYVRDNCKPLRRSMSCTDPEHVELFELIENMLMFEPLARMKLPEALQHRYFNRLPENLKIPCKMDASTNPRINGD
The following text describes a protein:
Function:
Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity. Exhibits lytic activity against E.coli and S.typhi cell wall substrate.
Miscellaneous:
MISCELLANEOUS: Encoded by the cryptic lambdoid prophage DLP12.
Sequence:
MPPSLRKAVAAAIGGGAIAIASVLITGPSGNDGLEGVSYIPYKDIVGVWTVCHGHTGKDIMLGKTYTKAECKALLNKDLATVARQINPYIKVDIPETTRGALYSFVYNVGAGNFRTSTLLRKINQGDIKGACDQLRRWTYAGGKQWKGLMTRREIEREVCLWGQQ
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. Functions as Fe-S scaffold, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Essential for embryo development.
Miscellaneous:
MISCELLANEOUS: Although plant and algal NBP35 proteins lack the characteristic CXXC motif in the C-terminus, thought to be required for Fe-S cluster binding, they can bind a [4Fe-4S] cluster in the C-terminus. Also, in this linage, no CFD1 partner protein homolog as found in other eukaryotes can be found.
Subcellular Localization:
Cytoplasm.
Sequence:
MENNGKEEEVPENANEHCPGPQSDNAGKDDACAGCPNQEVCATAPKGPDPDLVGIAERMATIKHKILVLSGKGGVGKSTFSAQLSFALASKNYEVGLLDIDICGPSIPKMLGLEGQDIHQSNLGWSPIYLESNLGVMSIGFMLPNPDDAVIWRGPRKNGLIKQFLKDVDWGDVDYLVVDAPPGTSDEHISIVQYLHATGIDGAIIVTTPQQVSMIDVRKEISFCKKVGIPILGVVENMSSLRQSIPDLKFMKMGMNGDNEKDVTQWAMDYIKENAPDLLSMVVCSEVFDSSAGGATQMCIDMGVPFLGKVPMDPQLCKAAEEGRSCFTDRKCNVSASALEKIVGKLLAIHHQ
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline. Probably hydroxylates skp1 on Pro-143.
Subcellular Localization:
Cytoplasm.
Sequence:
MDISNLPPHIRQQILGLISKPQQNNDESSSSNNKNNLINNEKVSNVLIDLTSNLKIENFKIFNKESLNQLEKKGYLIIDNFLNDLNKINLIYDESYNQFKENKLIEAGMNKGTDKWKDKSIRGDYIQWIHRDSNSRIQDKDLSSTIRNINYLLDKLDLIKNEFDNVIPNFNSIKTQTQLAVYLNGGRYIKHRDSFYSSESLTISRRITMIYYVNKDWKKGDGGELRLYTNNPNNTNQKELKQTEEFIDIEPIADRLLIFLSPFLEHEVLQCNFEPRIAITTWIY
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
Subcellular Localization:
Peroxisome membrane; Single-pass membrane protein.
Sequence:
MNEELINSAVSFLKDPQVGGSPLTKKVEFLESKGLNQEEIEEALKRANDNSTTTSSSSSSVASSNSSNTTSSPSYQLQQQQQQQVYSQPPIDYYNVVPPPVPEKSWKDYFIMATATAGVTYGLYQVVTRYLIPSIIPPSQSSIDKDKETINEEFMKIDKILDQLTFEQEEIKHANETKLSEIDTVIENVNDFLNKYNKDKLKFDDDLRLMKLEIDNLNNSIEKNMHLTKENINDELGEISQELQSLKNLIKARSGSNNNQTNGGNGGGIEARKIAPVSSIPSASEILKKARAKNAASTTPEPKQEPVKSEDTKSEETKSKETKSEETKRSEGITKNGVMAAGIPSWQLQHKEKEAQKKSNQEQTSNNNNNNNNNSSGIPVWQQAAAAAATTSSVDTSKSEEEIKEKIKSVGVPAWQLNASTSSGSGSYNNNNINGNDNSKNGPQQQQSSSAE
The following text describes a protein:
Function:
Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. Has a preference for ATP over CTP as a cosubstrate.
Sequence:
MAEFARDHGSRGTRVVLITSGGTKVPLESRTVRFLDNFSSGRRGSASAEYFLRAGYAVIFLHRHRSMYPYSRRYTSHNWLDTLRLVPSSDASGHQVQVQQSQLPDIVRVLQEYSSMKESGRLLPVEFNTLSDYLHLLQAAAQAFSPLGSNAMFYLAAAVSDFYIPASEMPEHKIQSSSGPLQITMKMVPKMLSPLVKEWAPKAFVISFKLETDPSILIERARKALATYSHQVVVANVLDSRRSYVVVVTNTDEANLSVSEEEERLGVEIEEKIIEDIVTRHTSFIGNLDEKSNASKN
The following text describes a protein:
Function:
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal zinc finger binds to poly(A) RNA; The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for pan2; Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the pan2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of pan2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.
Sequence:
MMYQQQPKNQKQCKNIALHGYCRNSDKCEFSHELTPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNSNGNGSNNTATSNNPIISPNSNIASPLKKSPIDNLTTSFQNLSTNQQTNHHWADHFQSGIPEYIPKQQLQQLQQQQLLQQQQQQALLLQQQQQQNYDDDQHLYPYGDNSVDDYEQHQYEPQPQPNNGIDPNMNNQFQINNFVAAQMRNASPQSYQQQFQQPNPSPQSSSQQQQQQQQQQQQAVYQQQQQQQPSSQPLAQNPSLQNNNNKLLQLQLQQHLQQIQAAQQQAQINQSYTPYPSYSQSVIRNKPGRRNIGSFFMSESLKQDILNQKSLLYLTLDPNDPRIKNIPPMLNKYHSLYPLDHDASRENQGKMFGYITSVYKAISTLDGLPYAIRRVEGFRLSSEYALQAAETWRNIQHPNIVSLKEIFVSKEFGDNSSLFFTYEFFPGSETLESKYLSQSGNPLSESVLWSFICQITSALKTIHSAGLVCRVIHPSKILLTGKNRIRMNGVGIFDVVNFDTPRILAQYQHEDLLLFGRLILTLACRSAQSTTTTNLSKSIEYVSNQYSKELYNLIVYLLTKPVINLPNIDEVVLMISGRLLQENNYLHTYTDDLETELSKEYENGRLFRLVTKLGFINERPLYDMDPRWSETGDRYLIKLFRDYIFHQVYDDGTPVLDFYHVVETLNKLDCGVDEKILLMSRDEQSLLVVSYKDLKKCIDSAFSELVSQKSHI
The following text describes a protein:
Function:
Plays a key role in the control of the eukaryotic cell cycle. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.
Sequence:
MEQYEKVEKIGEGTYGVVYKARDRVTNETIALKKIRLEQEDEGVPSTAIREISLLKEMQHRNIVRLQDVVHSEKRLYLVFEYLDLDLKKHMDSSPEFVKDPRQVKMFLYQILCGIAYCHSHRVLHRDLKPQNLLIDRRTNSLKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFAEMVNRRPLFPGDSEIDELFKIFRILGTPNEDTWPGVTSLPDFKSTFPKWPSKDLANVVPNLDAAGLNLLSSMLCLDPSKRITARSAVEHEYFKDIKFVP
The following text describes a protein:
Function:
Required for embryonic epithelial tissue repair, but not for the assembly of the actomyosin cable at the wound edge. Probably acts downstream of rl in the regulation of Ddc and msn transcription to promote wound healing.
Subcellular Localization:
Nucleus.
Sequence:
MASKRKHQASQKVKEESFKKHTLDSDEEDSDDYEREYLNDSDIEGGEEGVAKVEDDVKVTPFNMKEELEEGHFDKDGHYHWNKETEAKDNWLDNIDWVKIGTQKNAFDPAKDEENSSDEEKNEPVGKAFNLSMNLMKMVEFMKPGETVKMTLQRLGKQRPVLTTLQRIKQKKAGIVDPKTQEISQLTELANEILSKTGNMDIYQDTYESIKAKIADLPGTSKPKVADDIDMYADDFETKELERSKTSSSDSSKPTTTTSEVTWEFKWSQDETDIQGPFSTEKMLKWSQENYFKNGVYVRKCGENTNFYTSNRIDFDLYL
The following text describes a protein:
Function:
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation, including snoRNAs and snRNAs.
Miscellaneous:
MISCELLANEOUS: Present with 1430 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDLPKDKSDRTHQRINLNNSGTDRTNDLYLHIVQTFGCIETTATENATKLLMLGDVEVEISASSVSIEWTQKSMISQTIADSIVIMIIGLCASDKNVLSESELKERNHNVWKIQELQNLFREQFGDSFSIDEGIGKKENVKNGSVTIGKSKATIDFSTMKLIDCNSNPLKGRVESILSIGQKLTTPLC
The following text describes a protein:
Function:
Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. Promotes clustering of HT2RC at the cell surface.
Subcellular Localization:
Apical cell membrane; Peripheral membrane protein. Cell junction, tight junction. Cell projection, dendrite. Postsynaptic density. Synapse, synaptosome.
Sequence:
MLETIDKNRALQAAERLQAKLRERGDVANEDKLNLLKSVLQSSLFSQILNLQTSVQQLKDQVNTTTSVISNVEYAHIPHTSPAVIPTLQNELFLSSNNGNLEAFTGSGTLHINGKPACDEFDQLIKNMAQGRHVEVFELLKPPCGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDNVQLVIARGSLPQLISPIVSRSPSAASTISAHSNPIHWQHVETIELVNDGSGLGFGIVGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEEPAAPNSLGITLSSSPSSIPEMQVDASTQKSEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGPTVHLTLMRRGVKQEAELTSREDVTKDMVLSPLNASGNKGGICSAFTVYASLPFLNVQPFLAENYEKDEDSSSLSRNTSILPIEEEGKHLEPGYPLLSAEIEDIEDAQQQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTSQSGLDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDVSQNAEEVQGPLAMWEVDVQHIELEKGNKGLGFSILDYQDPIDPTSTVIVIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVQALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLHPRHSCEEEGPADRALFRADLALVDTNEADLADESTFESQYSPDNDSIYSTQASILSLHGSACSDGLNYGPSLPSSPPKDVTENSSDPVLDLHMSLEELYTQNLLQRQDESPSSVDLSMAPASGFTVNDYTPANAIEQQYKCENTRTWAESHLPNEIISSAELTSPVLPDSTGKGSEFLIQQSSLTSTGECVMLQNLSKEMFERTITIAKGNSSLGMTVSANKDGLGMIVRSIIHGGSISRDGRIAVGDCILSINEESTISLTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQPGGVMALDVLSSYTGRDIPELPEREEGEGEESELQNAAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLDDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLPHNLYPKYNFSSTNPFADSLQFNADKELQNSSRVTFRCSPTNPFAPTPFKAPSQSESEPEKAPLSIVPPPPSSAFAEMSSDHTQSSASKISEDVDKEDEFGYSWKNVRERYGTLTGELHMIELEKGRSGLGLSLAGNKDRSRMSVFVVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVSQMAVCPGNTVEPLPSASENSQNKEAEPTGTTSDAAVDLCSFKNVQHLELPKDQGGLGIAITEEDTLSGVVIKSLTEHGVAAKDGRLKVGDQILAVDDEVVVGYPVEKFISLLKTAKTTVKLSIRAENRDPQAVASAAGAASGEQKSSSLALMAPSSGSPEPESIPSTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEDVYDTLTIELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLVQGDQILTVNGEDVRNATQEAVAALLKCSLGTVTLEVGRIKAGPFHSERRPSQSSQMSEGSLSSFTFPLSGSSTSESLESSLKKNALASEIQGLRTVEIKKGPADSLGISIAGGVGSPLGDVPIFIAMMHPNGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNAPGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTALTSSSIFQDDLGPPQCKSITLDRGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDRRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVLS
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MAKNRKRRKRRVPEILWRLFRHRARTLADTIVSLIPPLPHCGCNGRRCLGCIGGDADSYLLRPQDPCDYRKLLSECFVVVSYNAPPLSTIYLDRRWSQLQIVRKTIEMIMCEQPGSSNVLCGGYSKCNNLSSIVELLTSSAWGLLLERVGDDIMVYLLKHTSIFLPLPHKMHCQVAGPPISDLCIGLSKHISDSKHQKPSLTDLGPQKKMERNDGAVNSTSEEQQLTSSFNRGGPVSFVSCVGCNGGNCLRKFSEPWGKKCVCTSSCEETMQTTSLGIANRKGAPLGECQQITSQISVQHRKRLRPSNYQQARKCSQLKFQGNDILGPYTTIPSKKESLHGRLQQGSSADLSPHHEKVFPFHEPMKHCCREGEKGVGLRLEGLDAMDGGVLIGEGRSAFCPRVQTLSMERGVNGDVDPLVLGEEPSASRLRAQTISMERGVNGDDDPIVGMTRVAMPTKVSAVVKRGSMTDEALRVEASRYVENSLLSVGGRELSSSTLSSGFDWAGAKEGTLSGLVSVIEGEEQLPLSIILVDGSNGELGTEGEKSSGGEGGAGGVSLRICYRIWKEKDVGGTVAA
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MAELGQESVEFSTLVNRAAEESYLSLKELVEKSRSSEMSDSEKKISILKYLVKTQQRMLRLNVLAQWCQQVPLIQYCQQLASTLSSHETCFTQAADSMFFMHEGLQQARAPIYDVPSAIEILLTGTYERLPKCTEDVGIQSTLTEKQQKPVLKKLDTIVRSKLLETTLPKEFSEVKIFDGTVTLCVPGEFKVLLTLGYRGHLSMWRILHLEVLVGEKSGPVKLEETRRFVLGDDLERRMAASENPFAILYSILHEFCVALVMDTVIRQVRELRVGRWKDAIRFELISDGNSGQSQSNAIGSMQMGQDVETDSGGLRTPGLKIIYWLDFDKSTGTSDSVSCPFIKIEPGPDLQIKCIHSSFVIDPVTNREAEFSIDQSCIDVEKLLLRAICCNKYTRLLEIYKELGQNSHSCRAGGDVILHSPVDQTGADYNKDDILDSEGQEVLRMRAYGSSFFTLGINIRTGRFLLHSSKSTIASSALRECEEALNQGSMTAAEAFISLRSKSLLHLFACVGRFLGLQVYEHSFSPVKVPKHVLNGSNMLLMGFPDCGSSYFLLMQLEDDFRPIFKLLETQPDPSGKAESSVTRIKIVDINQMHLLEGELNSSLLDYNTLTVTSSENDSVPSQASDHGLLSDLTVQGSGLSGFSSLVDEIFEQERRSSASAGAGSNWNGSLYPANNSYRGRVPSASTSSITSRSTTMKKMSASKSDQDLASRSQHSAEVGSYITGGARVSASSARGNTFRNSVSTPDSPMTQVSRENGSRKRTLLDMLDFLPSLKSSDIVAQSSKRRNFSNTTATQNQLSNVSNIEKYRYVNLIAEANKGDAPSSIYVSALLLVVRHCSLCIKHARLTSQMDALDIPYAEEIGLRTASSNIWFKLPFARNDTWEHICLRLGKKLGSMYWDVKISDQHFIDLFELQKGSSDTAWGSNVRIANASDIDSHIRYDADGVVLTYNSVEADSIKKLVADIQRLSNARTFALGMRKLLVVKSDEKTEESRSKGSLEVGDKYIEQMRKAFKIEAVGLMSLWFSFGSGVSGVLARFVVEWESGKNGCTMHVSPDQLWPHTKFLEDFINGTEVSSLLDCIRLTAGPLHALAAATRPARAAPVSGAASAVPTLSRANVNGQMPNGTNPNVGHGSGPGTGPGGNPGASAMLTAATVASRGGPGIVPSSLLPIDVSFVLRGPYWIRIIYRKYFAVDMRCFAGDQVWLQPATPPKGGPTVGGSLPCPQFRPFIMEHVAQELNGLDPNFAGGQPSAGPTNSNNSAASPGPQLSATNGTRAGPTVMSRPGNQPVGFNRSTNAMSASPNSLLVRRATGTVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFNPSQQQQQNNSVIGQDELTQSEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKSLAQAQGSDIPPAQRSRIELCLENHSGLYTDGNSENSSASKSNIHYDRPHNAVDFGLTVVLDPAHIPHINAAGGAAWLPYCVSVRLKYSFGENPNVGFLGMEGSHGGRSCWLRVEDWELCKQRVIRTVDMNASSGGDVNQGRLRMVADNVQRTLHNSLQSLRTGGGGNTT
The following text describes a protein:
Function:
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Secreted.
Sequence:
MATPSAQQQQQQQDYFRSVSSDSTTYMMVPTGGPSGAARRETPSKMWLAMVVIVVVVLQIASTTGLFVYLNMSISQVRSQGVTEELRCLGLLNALDQDIPDQVAQLLGEPCIKLAEGIKAYISKVTENIISKQTFIEARKMPISFNNSNFMSHVVQRPSAHLTLRDTTSQAGVANHAAITPGLHQSCRHMVRSWANQSFGAHLHNMTLSNGKLRVPQDGRYYLYSQVYFRYPSPVASDGDQRSVSHQLVQCVYKKTSYPSPIQLLKGVGTKCWAPDAEYSLHSVYQGGLFELRAGDELFVSVSSPTMVNADESSSYFGAFRLDL