lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization; Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
Subcellular Localization:
Cell membrane, sarcolemma. Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Postsynaptic cell membrane. Secreted, extracellular space.
Sequence:
MTRTKWGTTNEMLINGKVFNYTIPNNTFDQQETATRYEVSDYNSGSSTLPSWLLFDQSAGRFTGFPTSGDEGSYRYRIVAISMQGTTNQLTAETEVTIIVSNGALPLRKISYIERENNACPRSEKVRVVNIVLQMNVPGLTGQARISLIEKLASRYQLHRSRVYLHHGDKGVPIIGQSYIEASTSGSSNTLKGTVSWVIGCENVMTGSQYGITIRKHIADGTFSQTVGNSIVGYNFVLGVPVEDAVSATASSGSSSSTTTISYSLRATPLVTVGLPSSSAVKSSYMLTPVPSQSLPKASSIVTSSVTITTSVNQQITATPTSPTTDVSIAPTTTTQEKPKVDNPIGTIVLRAGFIYRFSIPVNTFSDKEDGNTRQLSLNLFYANNSAVSQWSWLQLDKIRQQLYGLPMTSNVGRHLYQLEASDSRNQMVRDPIEVTVQRTEPPKLILQLLLEVTYDRFATDLALRIAVMEDISRIVGDRNVMLQLDDFRYDGFRSTRVRYSNYTLNAKACDVNAYSSIIRKIESIKSVSSIEVYRALGVINCVPETSATPTVITDRQPTATSLPTNKPPVVMQSLGQLDAYAGRIFEFQIPADVFLDAEDGNTRNLSLALLTENAIAVKSWITLRGNRLIGLPLEGDAGIKRFLLRATDSRNAIGYDSFNIKVNPLPQQYNYIMSMLLDLNYDVFMANLTRRINLVTEIAKSFQESIVKNLCLRSITSGSVNISWTNVALDALPCNASIYESLSRNLSSLRSNPVFNTGAYPVTGNNIKPSAECSAVVTVTVPTVQPSVNWIGTVLPATLSACLFIILILIIFFMYRNGKLFGNKRNKSEKALKASGGSSSSLPNTGKIVRDDDDADDIPDRHNKSMGTNLNSILLMEDFNPDSPKPPQY
The following text describes a protein:
Function:
Activator of KIF1B plus-end-directed microtubule motor activity. Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MAASATSELSSLCEKYSRVVTLSEVESRKDPETDPFRSKYKARELLKEIICTLRNQYIGEDDGESDQPQKDQILEGSDSEGCGSGCVGGSPAALRAAKLGVIEHLLGVNHVETEELSAGEEHLMNCLKLLDKYSMSRENISINIQTRNQLGILWAGRDETEKAQGFLETAESLYIQYMKQDGQPPMDLSDFFVTEGESVLDQERTKRFEMAHTYTLYYLAQVYKNLEQYEKAGRYCHTTLQRQLEFNHFVPLEWAINAATLSQYYITKSRYMEGRHCLAAAVVVAGLAGEVPSEAAAQENEAEGEKREQLRQKRAEIARCWIKYCLNLLQDAKKLLEDNIGELDVERQAELKARRRQEDEEEEKGLKSAILFGSRDIFDSILALEEKVSCAYPLDFEEARAIFLVGQNYVTEAKEYFQMDGHVTDHIEVVQDHSALFKALSFFEEDYERRCKMHKRRIDMLEPICKDLNAQYYLLICRQLQFELAETYYEMMDLKLALADKQDELDAHTVKKFNHLCAASIKYYKMFLDSIRTADGKFPEKLEDDVLRPALVAKFRVARLYGRIICPDGATQLENLDKSLECYRFVVDYCEQDTEAKKAVETELELSEEMAGLLPIKIERLRAKQAALN
The following text describes a protein:
Function:
Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
Subcellular Localization:
Secreted.
Sequence:
KQFTKCQLSQVLKSMDGYKGVTLPEWICTIFHNSGYDTQTIVKNNGKTEYGLFEINNKMWCRDNQILPSRNICGISCNKFLDDDLTDDVMCAKKDLDSEGIDYWLAHKPLCSEKLEQWLCEEL
The following text describes a protein:
Function:
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
Sequence:
MSVVLKAAAEAGSGRRVPPPLPVPELQQTLVWYLRAVQHLVSEAQFRRTSAAVEEFRRAGGAGETLQRRLLERRAHTHNWVYQLWLEDMYLKNTLPLPVHSSPALVLPIQAFREPGDRLEFAARLILGVCELKTAVDRDSLPLDSAGSGVPLCMDQYKRLFSCYRRAGLQQDTLISTEPSQNTHAIVACRNQFFVLNLSVGCRTLSQSELQHQLLWITEHTHTHTHTHTHTHTTPEQPPALGLLTAACRRDWATARQQLLTDEENRRSLELMERCVCVVCLDEPAGLEPCAADRAALILHGGGPDRNGGNRWYDKPLQFVVGADGVCGVVCEHSAAEGIVLVQCVEHVLKRTSVSELEHTHLSNTHHSDTHCSDTHVSGWTTGLPQPRRLLWKCSPRVEEMLAAAANQLQGLVWDLHMRVFVFSAFGKTLXKQQRISPDGFIQLAIQLAYYRTHSRAVSTYESASLRRFHLGRVEIIRSATAEALRFCTAMSGGGASVQDSEKMEKLRAAADAQAQLTLRAVTGNGMDNHLLGLREMARQMEMQTPDIFSDETYKISNHFILSTSQVPTEMEMFCCYGPVVPDGYGVCYNPQSDHIVFSVSSFRENKETCSDRLAEELQVALLDMKDLCMKHMKH
The following text describes a protein:
Function:
Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKDDKGRSDTVNGYYISNSKLSSGFYKRNNANTASNDEKPNLEQNDIPSVTSSGSSTPSSISIEKEIKISKGNVIVKAIRSWSLYVAIIAILLLLVILHSFQGRPQDNGCGKSYVWPSYVRFVDFDERYTRFANKYSLYLYREKSVEESDEPSGIPILFIPGNAGSYKQVRAFAAQAAHVYANAYAEDADGTLNAGKLVPDFFVVDFNEDFSAFHGQTLLDQAEYVNDAIPYILSLYRQNRKISSEYDNEAFPPPTSVILLGHSMGGIVAQATFTMKNYVDGSVNTLITLATPHAMAPLPFDRHLVEFYESIKNFWSQSFLLSPEENSLDDVLLVSIAGGGLDTHVVPEYSSISTFVPPSNGLMVFTSGIPSVWAEIDHQAMAWCENFRRVLIRGIFAIMDARTSKCTVSLNLRKELLSRAYIQGSSFQNDITQISKPIAQYKALDLDLTYVYSEMPGQLLFLNQLGVSYIRHHIFPIPKPTSSIDRFELLTDQPIDLSSSNIKVLACRLDPKIDNTISALLENGNNKVINANCHLLRELVTLLPASTAYTSSPYGGDSFYNYVLPKEKMDDYHFILVSDDSKAPASGFVVGGFSNVSLDPKTIKGSQIELFKSGRKFQFDTKGSISKRFRFPGIQSSIMAYTISVTYELYPGAVPQKEFTPMLKQSIESPFETKYHVNMSNTELSVHGISPFMEFFGKESEKSLTLEFFLNPAIYKSVYVSIQPSYYRSAGRLLMRYRTLLASFPVVVISLAAYNQFRYFHYGSAYLSMSAALEVMIRKGLIKLLFLVSILSIAFSYLISRVELIVADGADPVASWKIFAMMVPKSFWKQNHLLFGLQTAQFWFLAPLLTLMFVGLVITASVIILCVMHLLAFIYGIYLRYKGLTFTGVCQAVKFSFQCLRTRNTRKLDHGEFKKLSSFLSQRNMYYANPSLCYVYGKKHMQARIIGIMLLLLMAMTVVPFQLVYGVALCTQTVTTAKALHLARFCTKSSHYRKKLWDFYNFSCTITILMLLLAPLDFPVLIVWARNLSMHWSIPFPTHHNFFSIIPFILLTEILRTGKMLPRLNDVEYYINNVFLFLLSFYSLIYGAEKPYLIHNVVGLYFFWLLFLYAKNGFFVQNISKWPIIPRMKYFIKHKFLRSIS
The following text describes a protein:
Function:
Guanine nucleotide exchange factor (GEF) which may be involved in the regulation of homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion.
Subcellular Localization:
Late endosome.
Sequence:
MATSISLEDSITIFEKDQNSDVLMSWCFPTITEDLKSVILNRTSLLQEKISLQFSFSKFKNSWIYIYTTSVETQQINKEDGSITQINVPDSLKRVVAFSLVLVRNQFNPEKYGSLAQIMSSVYKQTGDCSKLLECQLRVFNRGQFDVGSMGKFVDSSFDVRRSYLQTSIKDIIQLFGEEIILIWSAMAMKKRIVVYSEKLSSLLKVIRALPLFVFHRQNWNILRPFVTISDLELKDLVSTGVYCAGFTDSSIKSREDLYDILVDLSSKEVSVSSQSKDQFILGSFHKDVLRFLLDSLDDEEITDQNVIKGLNLKMKELLTKLESLKETNEETGKSSITLESLETRKLPNGMSTFLFNIANAEGLNG
The following text describes a protein:
Function:
GDP-mannose transporter that may be involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MSAVKLEAIVCHEPDESELSHLSDNGSKTKNGVVFQLLDQKSSEHRWFSERFLRWRRRYLPVDGDNRRDHGSVKQSGPLVSGAAYCISSCSMIILNKIVLSSYNFNAGVSLMLYQNLISCLVVAVLDISGVVSVEKFNWKLIRVWMPVNVIFVGMLVSGMYSLKYINVAMVTILKNATNILTGIGEVYMFRKRQNNKVWAAMFMMIISAISGGITDLTFDAVGYTWQLANCFLTASYSLTLRRVMDKAKQSTKSGSLNEVSMVLLNNLLSIPFGIILIILLGEWRYVISTDVTKDSMFWVVATASGFLGLAISFTSMWFLHQTGPTTYSLVGSLNKVPISLAGLVLFNVPLSLPNLFSILFGLFAGVVFARAKMS
The following text describes a protein:
Function:
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell membrane; Peripheral membrane protein.
Sequence:
MLQFHFFQFLDWDLLKFFFYFLSFIGVFLTIRLRFPQLRFLFLAIKIFSGNMDYKGSRGRLVHSQAFFSGTASSLLPGAVIGSALALMIGGPGVLFWIWISSFFIMPLRFVSSTLAIRFRTKTDSGRYLSGPMYFIESALKARWLAVGFAAIGLLTVLVMGGVVPMLYVTHIANRVFEINGMTVPFLLSVILVFIVLGGVRRVGKVSAYLAPIGILLFFLSYFFLFKGSLMNFKDFIWLSFKEAFQPGAAITGGGFALARVYSMASGIFFVSTETGIGKSAGLSGVVRTDYPAKQGLVSMLATFFEGFIISTLVVYALSSYGAFKMEEQLVFLNALFQGNTNPINAAFFVSFLLFGVVSITGWFYTGEQKALYVFGEKFANFFRMLFLFTILAVAYLYVKNGEQILFEAFGLGYSLSIITAVPVLISLVLLEKIARTELKRFLTESGARYEVLKDFYLLILSVVPKNLLSRLFGLLASSRLPRFILIPILKAFARAYKINVDEAELEIQEYNSLNEFFTRALKAEARIIDSADDEMVSPVDAKITGYGDINQRIIIQAKGVDYNLKELLGGSKYLEDFTNGKYITFYLSPQDYHRIHSPAYGKILGYYYEPGKLFPVNELAVFGIRGLFPKNERLITYLQTEYGKVAVIKVGASNVGRIRVTYDNKIVTNTLIRTARTVEYKEVSIMIGKGAELGRFEMGSTVILLMEKDTFQFNSLTVNERITYGTTIGKFKKKKCKLPK
The following text describes a protein:
Function:
Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.
Subcellular Localization:
Nucleus membrane. Sarcoplasmic reticulum.
Sequence:
MLTMSVTLSPLRSQDLDPMATDASPMAINLTPTVEQDEGEEAMKDMDSDQQYEKPPPLHTGADWKIVLHLPEIETWLRITSERVRDLTYSVQQDSDSKHVDVHLVQLKDICEDISDHVEQIHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQGLQDANGNYTRQTDILQAFSEETKEGRLDSLTEVDDSGQLTIKCSQNYLSLDCGITAFELSDYSPSEDLLGGLGDMTSSQVKTKPFDSWSYSEMEQEFPELIRSVGLLTVAADPVPSNCSEAVSGEAAQVSLPAEDKGGLEEDNTSTVEEQPGLPPATSPSQEALTNAIQPSSEAAKQESNSSSQLGAKNQQPLPCDNATPKRSIRDCFNYNEDSPTQPTLPKRGLFLKEETFKNNLKDPHGKKRMVDLKPEMSRSTPSLVDPPDRSKLCLVLQSSYPNSPSAASQSYECLHKMGHGNLENTVKSHIKEISSSLGRLNDCHKEKLRLKKPHKTPEEVPPCQTPKRGTGSGKQAEDIKSSVVPNGIPAGPSQAREGPETDSTSSSSLEPCHQRSWNAKLPVQSETSNSPPFTQSSESSVGSDNVSSPVPLLSNHKSKKSYSSSPSHVTRNGQVVEAWYGSDEYLALPSHLKQTEVLALKLENLTKLMPQKPRGETLQNIDDWELSEMNSDSEIYPTYQVKKKHSRLGRVSPSSSSDIASSLGESIESGPLSDVLSDEELCMPLSGTKKYIDEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAETDGLKLYLETHLSFKLNVDSHCALKEAVEEEGYQLLELIASHKAEGLKDMLRMIASQWKELQRQIKRQHSWILRALGTIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHSVGGDGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRDLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEKIQDTMAGHSGSGPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEGTMNVEKQLQYFKSLCCEIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDLNGMSEDALEWDETDISNKLISLNEESNDLDQEPQPVMPSLRLEKTGSGEPGYEEESGDHGGSQYASSITAPSSPHIYQVYSLHNVELYEDNHMPFLKTSPKFTSVTQPSVLTKSLSKDSSFSSTKSLPDLLGGSNLVKPCPCHGGDMSQNSGSESGIVSEGDTETTTNSEMCLLNVVDGSPSNPETEHLDPQMEDAVNVLRQKFKDEEECIKLPNSSQSSISPVGCVNGKGGDLNSVTKHTPDCLGEELQGKHDVFTFYDYSYLQGSKLKLPMIMKQSQSEKSHVQDPLLHGFYFDKKSCKSKHQATELQPDAPPHERILGSASHEMDRNSYKSGDVEKTLPGMQNAKRLSLLSHSSSVESLSPGGDLFGLGIFKNGSDSLQRSTSLESWLTSYKSNEDLFSCHSSGDISVSSGSVGELSKRTLDLLNRLENIQSPSEQKIKRSVSDITLQSTSQKMSFTGQLSLDIASSINEDSPASLTELSSSDELSLCSEDIVLHKNKIPESNASFRKRLTRSVADESDVNVSMIVNVSCTSACTDDEDDSDLLSSSTLTLTEEELCIKDEDDDSSIATDDEIYEECNLMSGLDYIKNELQTWIRPKYSLTRDKRRCNLSDEIKGCKDISSSEMTNSSDTLNIEALLNGSIKHLSENNGNGKNLSHTRELGTKGENKKNIFKVNKDPYVADMENGNVESTPERQKDKLNGISKESENLGSTGKKISESEHCQCKAFMDSSDDSHIAGKESVPQTVRHLSKNCQDHHHLENQSAASTPTEKCWPELPSETRIINRQDSDVLKSSSNDAPRMAGKSTGCCLELEQNETEENASLSDNISCCDCEPDVFHQKDAEDCSVHDFVKEIIDMASTALKSKSQPENEATAPTSLTQIKEKVLEHSHRPIQLRKGDFYSYLSLSSHDSDCGEVTNYVEEKSSTPLPLDVTDSGLEDKEDIECFFEACVEDDPDGDKPCFSNVPPNEPAVPGEAAMPLPAAGSSHFSDMSLSAHDADSVALSHPPPEKGSDSGKEVDGLPQASNVCGESSELTTPSRLGSEKESSENRGESGMPEEHRAASAPSRVPGLSSKAEQPKDKDELPPNPKTLTCEENLLNLHEERHKNMHR
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MFQSLLNLKYSWQQSSKEDINNKELVDAAISILGFSIKNLPSEKKKEIIQQIYSRTIWFTYRKNFPQILNSQQTSDAGWGCMLRSGQMIWAQILRVHIRQKKQHSKDYQYKLLCAFSDDDDDEHKKMFTDNFKLCLSPYSIQKIEAISQIKFSMKPCQWYRPDQILNALSLLHQQKQLEGSEDLEITISDSLLYDRLYSEMYGLKMDCEHIVNEIKQDKNKEISKICNICQKKDPKALAIFFITRIGLDEINKEYLPFLNDLIDLPQFQGIIGGRDDKAYYILGRVNKRLIYLDPHYIQEHINRGNVVMLKDTFFCKDVKYINEEQMSPSIALGFYCQNQSELDKFFNSIEQIKKNYDNEKTFGYISRITPNSYIIGFDENDILVIKEDEI
The following text describes a protein:
Function:
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
Sequence:
MTGMKWNEVWRLPFVGDLEELPFKDDKVCVVGMFGKSQVGYGTKSTTINTILDREVFPLHWPDGAGLQSQEETYVEAFYDKSKNVIYLHLVSVFDTSMLVSLCTNLDQDLPYADVHKFWRDQELQHARGLIFLFHVCHILVALHPTCTFDMSYGQLLRTVDSVRLKMLPILQDVLRDAPVGAEWKSAGRSCTPRLLFVFQKSCLPTESETRAESGKSKGTKHSPKKRLQPRIEDQIYRIFRKSRLLTNQSKDCLFTVPPNQTFVYIQSGDGPVDAITNLLSNLHQNCAMGKEAEAPASRSYQMSRRTNQSALMNPPSILLPTKPNGADDSLLGFLWQHIDLVLSGKGFDDSVGRNPQPSHFELPSYKKWLSVCNTLYELLLTEAGQHAKVQGCLETMGSSLDVETKFSDSRCSKVLPLASSAYQNSLPSHYTSKVHNNQLAQAMKVFKQHAHGPAYEHYVLQLQEDCEKFWANGRQLCEERSLTGQHCVHPFHTLPKPGQPADPEPSDSQVVPCMPHNSRARSLCACNCGRKQAQRDDPFDVKAANHDFFHLMEEKCCSSLEHISFPVFQRQPQGTPGEEVAPTPEEDPPPTFQPEVSIKTDTEPSKRKDSVLSSATTTASGGLSLALSLGQSGGSDMFVSMLHADQNSDSLAAVGMDSMMAADSQQQEAEAEKTSQLVRQPSVTESLPGMLHSDCPPGILPKFSSWELVSLGPVSQYYPSMGLEQPGFIHGSNFLLAWDIPIHTERPQQGDQAWPAPGESQSVRRSIPHGGKPRRGAKDSDSFVRVYVGYEYECARGHRFLCSGPDKVMKASNSGSVKETAMKLLSMDMPLYFPCPCPSRGAKPHLGQLMRVFITTPDPPVQIHLHPRLQPGPPPCPTFYPQDEDIPLPPSRLWVLRLPFVYVGEAGVISPPRDSQPLLSCKVLKGLLKATIVEEGD
The following text describes a protein:
Function:
CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex.
Subcellular Localization:
Secreted.
Sequence:
MGFLKFSPFLVVSILLLYQACSLQAVPLRSILESSPGMATLSEEEVRLLAALVQDYMQMKARELEQEEEQEAEGSSVTAQKRSCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAFGRRRRDLQA
The following text describes a protein:
Function:
Forms a complex with CCMFC, CCMFN1 and CCMH that performs the assembly of heme with c-type apocytochromes in mitochondria.
Miscellaneous:
MISCELLANEOUS: A stretch of 270 kb of the mitochondrial genome is duplicated within the centromere of chromosome 2 resulting in the duplication of the gene. The expression of this duplicated gene (At2g07768) is not demonstrated. It is also probably not RNA edited and therefore differs in all the positions known to be edited.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
VDTGREQAKRVVRNGKKETTTLPLCWTAGANTVVSDQDQEPIRIWILTCWWFLTVGILLGSWWAYHELGWGGWWFWDPVENASFMPWVLATACIHSVILPLLHSWTLFLNIVTFLCCVLGTFSIRSGLLASVHSFATDDTRGIFLWWFFLLMTGISMILFYQMKQQASVRRTYKKEMVVARSTLVHLRHSARAQPRPVMLWKN
The following text describes a protein:
Function:
The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGLDDLVDLENIPIEQVFENLKCNKEGLTYTDVEERLSIYGHNKLEEKTESKFLNFLRYSWNPLSRTMVAAAIMAIVLANGGGRPPDWQLFLGIVTFLIVTNSSYTFVAVKLTSDIAARVQFLHKFCRVLRHGRWCEVDSSNLVPGDIIHIKMGDIVPADVRILNFFTTDPVVKIDLSDLTGESLPVTKSRIGDCAYSGSTCQKGEIIAVVIAIGVRTRYRNAAAPHVVKSSNQVECFRRVSKGIGNFCIHFVAVVMMVEIIVMYCIQHRAYRSGIDNLLVLLIGGIPIGMPLTLLLIMRHGTVTSSHYVIKRMTTIIDMACMDVLCSDMTGTLTLGMLDVQRDLIEVFANDINKDTVALMAARACNSEECARRAGISLRLRCCPTEKQISHTYSDGKGKKHRVSIGKPEHILNHYAHNKSDIEHRVHSVINMFAEKGLKSMAVAYQEFPSDIEHRVHSAMDIFAEKVLHSIAEQANPSDIEQSVHSVIDMFAEKVLHSITLAFQEIPSDIKHTVRSMIDVFSEKVLHSIAEAYQEVPHGSKEKSGSPWQLIGLLPFVDPPREDCASSIRELLNHGVNVKMITRDHMVIGKEIGRRLGMGTNMYPSSALLGHNDKSIAADNDLSIDEIIENADGFVSCALPEQKYEIIKHLQSRKHVCGMIGGGVDDIPALKKADIRIAPYGVTEAAQNAADIVLMESGLKYLCEAVLTSRSITVRMKSCMVHAVSIAIHNVLGFMLLALVWKFDFPPFKMLIIALANCFINVIASQNRVKSSPLPVNWSLSEILTTGIVLGSYLAMSTVIFFWAVYETNFFSLDKTYMKFVLAVLLQVSSSNYALIFVTRTGKLLPGCDSLLFIWVSYQLLFTMLAVSGDQSICWSCAGKIWLYNIVFYVPLYCIKFFNQRSRKGFLKSIL
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Subcellular Localization:
Nucleus.
Domain:
The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails (By similarity).
Sequence:
MEVVEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQCYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSSKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRNDMVKISMDIFVKKFQPDRYQIWKQGKDIYTIDHTKPTPESTPEVKTWLQRKKKLRKPPKSLQGNKPLCKRPKPEEDEEFAEFSGEEGANPAMGPRHLKVTEKPEKALKLGKLEESSAKEALDTRIQVDQSLLNDTKLSGKGCISSSVTAEIPPEDNRASAVISPSQLKEGADCIPLSHGHQAGKESHLLKILKLESPKIPSPLPESNKVLTEGEENDEEGHGSNLEPGEIPEALSEERNGLNIPKIIEGQPKTTKSWRHPLGKPPARSPMTLVKQQVASDEELPEVLSIDEEVEETESWAKPLIHLWQTKSPNFMAEQEYNATVAKMEPNCAICTLLMPYYKPDSSKEENDSRWETAVNEVVQSGRKTKPIIPEMCFIYSEENVDYSPPNAFLEEDGTSLLISCAKCFVRVHASCYGVPSHEVCDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNQWAHVICAVAVPEVRFTNVPERTQIDVDRIPLQRLKLKCIFCRHRVKKVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHRVNSNAKSKTCEKAISVGQTVITKHRNTRYYSCRVIDVTSQTFYEVMFDDGSFSRDTFPEDIVSRNCVKLGPPAEGEVIQVKWPDGKLYGAKYLGSNVAYMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADVIQGERKRQRVLSSRLKNEYVDDPVYRTFLKSSFQKKCQKRQ
The following text describes a protein:
Function:
Peptidoglycan-recognition protein probably involved in innate immunity by binding to peptidoglycans (PGN) of bacteria and activating the immune response.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MDSSHIAVRVARRSPSPAAVSQSSYGSLGSSQDIHIRVDKEGVASESTPLLAAAQRSIKTSSSLTASVSASSTTPSNCRRNPTLHEDCFNWRSVGLLVMCASALALAAYLLWRQTQTPDFGYRLSIVGHGIWSDMELQGRGTLFDPIGVGTVIFTHTGSNECHDDCPDVLHKLERSHVGELPYNFLVAGDCQVFEAQGWHYRSQYPRDLNGIDSLVMAFVGNFSGRPPIDCQLMAAQALILESLKRRILQPIYQLFVLGSYTDALQRELRHWPHYASHQTSK
The following text describes a protein:
Function:
Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.
Sequence:
MSFDALLRRGASHAYDIVIAVTFEQTSAAREAFFRRTFEVPSPFSYQKNSITVHRTLPGTRNQQPTPRLSTSQIDLPQTPLPASITPSHPSSPADNPTSRSLTPAQDKPLTTEDSGPEELAMVIDTNEPCISTSPSSSSRSVEASVDQLPCGSRSESAQAVDQSAQMDDSAPEDQPLWERVDKIKPSVDDNVTSRPWSPSSLVVYERLTPVAPIKPPPTRQKVRSKTVWIKGTFHVSLSLGTEEIDKASELIEKNLFLLGATAIEDKLQVGAPDMFYTLQLAGIKVWVLTSDRQETEINIGLSCCLISESMNLVIVNEESADFIQKHGKRLGFALDKSTSNIKGSITLAIGDGANNTNPPPDAISAARIHSPIKKKKNIIHRSIWTCDGTHGALPAPQGLYDPDQEKDSCGVGLVCHIKGQPNHKIVSDARSLLCNMSHRGATGADARNGDGAGVLTGIPHAFFLREASLLSIDLPAQGRYAVGNVFFRPNPPEALIEHKATFERIALTHKLKVLGWRELPGNNSILGPAALSREPIILQPIVVPDSNEPDAYFDEKEFERQLYVLRKHASHAISLADWFYICSLSNKVIIYKGQLSPSQVYEYYYDLNHVLFKSHFCLVHSRFSTNTFPSWDRAQPLRWAAHNGEINTVRGNKNWMRAREGNLSSDKFGDQLESLYPIIEEGGSDSAAFDNVLSRQWRHEEAIMMLVPEAWQNNPNMDPAKTLFTFSDGRYCGANLDRNGLRPCRWVTTDEDLIICASEVGAITIAPETITRKGRLQPGRMLLVDTQEGQIVDDKELKMATAQKKPFREWINNQMLPRLYFLILSMKPESRKILVFWPLDIRSNNLTYKGAQISEARGLHQTVIEQCFVGTASRIQGTTFELLALDTFEFHERGFPSRQVVQPPGLPESGEYHWRDGGEAHINDLVSIANLQDAVRSKNQSAYDVYSQNAQKQSAQSIPLEQVEPWHELVKRFCTGAMSYGSISQEAHSALAIAMNRLGGKSNTGEGGEDASRSLIMPNGDTMRSAIKQVASGRFGVTSNYLAGTDELQIKMAQGAKPGEGGELPGHKVSESIAKTRHSTAGVGLISPPPHHDIYSIKDLKQLIYDLKCANPRVQVSVKLVSEVGVGIVASGVAKAKADHILISGHDGGTGASRWSGIKYAGLPWELGLAKTHQTLVLNNLRGRVCLQTDGQIRTGRDVAIAALLGAEEFGFATTPLIAMGCIMMRRCHQNTCPVGVATQDPVLRAKFTGQPEHVINFFYYVAEELRTHMAKLGFRTLNEMVGRTDLLKVDETLRNPKTVNIDLSAVLKPAWKMRPGVATFKTKQQDHKMYTRLDNKFIDEAEPALAKGLPVRIKADVKNTDRALGTSLANRVSKAYGEQGLERDIIHVDLRGSAGQSLGAFLAPGITLELEGDANDYVGKGLSGGRLIVYPPRSSPFKAEENVIVGNVCLYGATSGKAFFRGIAAERFAVRNSGVIAVVEGVGDHGCEYMTGGRVVVLGSTGRNFAAGMSGGIAYVLDMARDFKNKVNSEMVELGTVNDPSEIAELRGMIEDHRHFTKSEQAVRILRNFNEFLPRFVRVMPLDYKAVLEAGAKAAIQSDPHKNMPGFDIKGDAFNPAEDKANTNVNDQVEIPSATLGHSEPPVVDLEDSMLDAESAKKIVEKLDKTKGFMKYKRLNENYRNPKSRTVGFPSAHVNLRKNHHPRRKKKLTRI
The following text describes a protein:
Function:
Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAGSVTSPPSGTPSPAPGGSRLEPPTPDDPRSPVSGSNDNKAMRPRSQSDPAEHDKKPVLATPPSGQNSKDGNKLLSRRYTSSTDEFRSPRRLHDESDLADERPLHHVTLMVIAMEKKVMAKPMQRLILLSLSASLGGRFVSTCCHRYPLSKVQDYVKLRSPFLLNDLATQHLLLDRQSVYEILEENGIPSPPHMVLRRSAGDVVVEREDAIEINGKVMPKPFVMKPLDAENHNIYVYFSQHDGGGAQHLFRKKKDKASAFLPDCNTIPEEGDFIFEQFLPTGGTDIKVYTVGPNYAHAEGRKAPVVDGKVLRDANGKEVRCPILLTTFEKDIARRVTQAFKQNVCGFDLLRTSDNKSFVCDVNGWSFVKRSPHYYVDCARILREMILSAISPLLLNKSYPVPSVDYTSDSTDLLALQSPQQPLRRDAPELRCVIAVIRHSDRTPKEKLKMNVTHVELLEVFKRWSPEGMSATKEVKLKSRKHLQDVLRRVQNLLRWDQRLSDEEKSNLKQIEHVLTRWPISGINRKVQFKPTSYVHTRTGKPIINKAQLIVKWGGEVTPMGLDQAQKAGVQFRETMYPSSDQDNGLLRLHSTYRHDLKLYSSDEGRVQMTAAAFAKGLLQLDGEITPILVSLVRKDNAVNALLDDTKPARAQMDEVKKKVHGTLLADQSWPEVAAKIAPLSAMSYSQRKALRKLDNPHKAMTRLYNLVVDFVTSLGDRIEQDPNVRAYQGEPLVLLRRRWEKLRDEFFDTAKQKFVVSKIPDIHDSIKYHLQHNAHFGIDQSSEILTLSQHLANVVVPQEYGVTNEEKLGIGYAIGEDLMRKIVHDLRVSAGQDAQHDVFQHEVSHRLNSGDSFIKVRSPNRHVRTRLYFTSESHIHALVNVLRCGDYGLFSAGPTRKYSYSDLVEGQSKDDQAGATANGDGDADRDEDYRSRAASDLASRWQPRLQANTDVPLVSSPEAWLSAKAYICKLEELGYLTHIVCRLFERHDMDGSDPARFFVEWALSPGLRSVEDSEASAATNHDVELAPLRILHTGMTLEQVERFFQSLPSRVTTPTVSESA
The following text describes a protein:
Function:
Involved in the synthesis of tocopherol (vitamin E). Methylates gamma- and delta-tocopherol to form beta- and alpha-tocopherol, respectively.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAHAAAATGALAPLHPLLRCTSRHLCASASPRAGLCLHHHRRRRRSSRRTKLAVRAMAPTLSSSSTAAAAPPGLKEGIAGLYDESSGVWESIWGEHMHHGFYDAGEAASMSDHRRAQIRMIEESLAFAAVPDDAEKKPKSVVDVGCGIGGSSRYLANKYGAQCYGITLSPVQAERGNALAAEQGLSDKVSFQVGDALEQPFPDGQFDLVWSMESGEHMPDKRQFVSELARVAAPGARIIIVTWCHRNLEPSEESLKPDELNLLKRICDAYYLPDWCSPSDYVKIAESLSLEDIRTADWSENVAPFWPAVIKSALTWKGLTSLLRSGWKTIRGAMVMPLMIEGYKKGLIKFTIITCRKPETTQ
The following text describes a protein:
Function:
Role in flagellar biosynthesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Bacterial flagellum basal body.
Sequence:
MNSIIDLFPAFLLVFIRISAFFVTIPLFGHRNVPAVHRIGFAFFLAVICFSTIDKPPSLEIDEHYMLLAFKEALVGLCLGLIAYMMIAAVQIAGSFIDFQMGFSIANVIDPQTGAQSPLIGQFIYTMALLFMLSVNAHHLLLDGIYYSFQYISVDQAFPNFGDEKFAYFIAKSFNAMFIIAFQMSAPVVASLFLVDLALGIVARTVPQLNVFVVGLPLKIAVSFIMLIVCMSVIFVVVRNVFSLTIETMRNLLALVGVS
The following text describes a protein:
Function:
Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers; Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42; Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Membrane; Single-pass type II membrane protein.
Sequence:
MISLSNSTPKEAKKEEPKRGEEALIIPPDAVSVDCKDTDEVIPVHQRAWCWCMCFGVAFMLAGVILGGAYLYKYFAFHQDDIYYCGIKYIKDDLILNEPSANAPAARFQTIEENIKILEEDNVEFISVPVPEFADSDPANIVHDFHKKLTAYLDLNLDKCYVIPLNTSIMMPPKNLLELLINIKAGTYLPQSYLIHEHMFTPEDIDPLVHVYKLFRDINTCRLSHTKVADSTVLSHHQFGC
The following text describes a protein:
Function:
May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGDIRQRNGSVSNNDTDLSVVPYTADDIRVLCHKVEDGKVGEEFEMRTLSEVPDGDAGESRPVNRGAFYRVCLPACCKRSDTHRDEDEDDGEEDTGENTVQKEKQPSCPGLGLMYSLLASVFFSIAALLVKKMEGMHAIQISAIRCFFQMLFVLPAMIYYKTGFLGPRGMRIYLFLRGFLGSNAMILLYYAVLQMPLADATVIMFSNPVFTALLAWIFLKERCTIWDVVFTVFTLTGVILIARPPFLFGGELSGIEGDYSSHIKGTVAAFSGAVGAACTMVILRKIGKRVHYFLSVWYYAVLGLIECVVVLFILDEWTIPSCGWDRWTLMAIGVLGIAGQAFLTKALQIEKAGPVALMRTMDVVLAFVLQFLFLNRKPTWWSLGGALCVISSTSGVALRKWYNSTRQKS