lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
Subcellular Localization:
Cytoplasm.
Sequence:
MTLSATPNLAKLLDPAPPGNLLLLPQVARMALFAAFPGPAVLLTTPDRVANYATAAALGAPVSINPGLREWETRAEHVVLDVNTALDLFPARPEDHALSLRVGASYPREELLARLERFGYERGRFEDRETDEPGFDLRGDTLELHLTPGAGLPADAEEGVWLRAEFFGDELDTLRQLRPGELTGEKIQSFTLAPTADYLTETKWDATRLELLPGRVFLDSPEFYASALEVLIDTLWPKLAGREVTSFGRTPLDLPDLHTGLETLPFYRARLADLERDVAEWRAGGYRVFILVRHDRTAAYLADKLLGTHEIPWLKVPRLNPGELGFLRSGGEGGFVIPEHKTVVITEDLIYGFQGGSALRGKKMAGRPVTDALGLSVGDFLIHPEHGIGQFLGLETRKVLGVTRDYLNIGYRGGSRLSVPIEQLPILRRHPGTTDDPPQLSSFDKKDWARAKEKARKNAEEVAAKLLVQYAARQVTPGNAFDPQPEWDEQVEKNFEFELTKDQVTALKETMRDLEKPTPADRLISGDVGFGKTEVALRAAHRVVGHGKQVAVLVPTTLLAEQHTATFVERFKGLPVRVEGLSRFTTDKQARNILAELKAGRVDILIGTHRLLSGDIEFKDLGLIIVDEEHRFGVGQKEKLRQLRGLPEMVDGKLTMTGDEKAVDTLALSATPIPRTLYMSMVGLRDMSSIQTPPKGRRPIQTILSPFDPLTVRDAIMTEIGRGGKVFYIHDRIASIGARSLYLRNLVPEARIGVAHGRMNEEELEEIMLGFEQGAFDVLLATTIVETGLDIPEANTILIERSDRLGLAQLYQLRGRVGRRAQTAYAYLFYPPRMTENAQRRLWAIADLQDLGSGHLLAEKDMEIRGVGNILGEEQHGHVQAVSIDVYTELLAEAVAKLKGEKVEAAPSISIDLPVNARLTPEYFVDADGQPNEGERIATYGRLSDARTLQAISRVERDLRKKYGPPTPEVQNFIDLAKLRLTALAKRVLSIGETMTQLQITFAYKALDYDAPGLKKFPHKTEVVTFPPSVKIDKRGIKPDEYARMLIEVLGYFG
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. Involved in the negative regulation of lifespan in a germline-dependent fashion.
Subcellular Localization:
Nucleus.
Sequence:
MASAATTTHFPSSRIPSEPCASSGPLFPDDVLFTTEASSASSSSCHVENDSRPLSPTMFTDGRTPVNISAKHLKDHPLHEPTGTSEVLTFYPTMREFKNFSQYIKKIEQNGGHLKAGIAKIVAPEGWTPRPTRKDFSDVDDYEITQPARETIEATEKPGAYFKRNVTCRRKMPVREFRTLANSAQYRNPRPDLKGSEIEKHYFDNILHGEPIYGADTEGSFYDAQVEEWNMNRLGTILEDTNYEIKGVNTVYLYFGMYKTTFPWHAEDMDLYSINFLHFGAPKYWFAISSEHADRFERFMSQQFSYQNEYAPQCKAFLRHKTYLVTPELLRQAGIPYATMVQRPNEFIITFPRGYHMGFNLGYNLAESTNFASQRWIDYGKDAVLCDCNKDSVKIDMTHFMAKYRPDEYTTWWTYWYGGGRELWIPKKKKEVPKKRRQSLADASKIAKRARLGASSTATDSDGSSGSSGSEEATEGSSFMRALPAGYTVHNWQLRPDYDELLRKYKKETKLLRSDTRIDFYQEREFNHARRAEWPHCAVCQYFQPPHMNAINHTVPNSSRRLIPKWCFSKTDTKKHEDHHEPPPPLDRLLTCSNCHVTVHSHCCSGGGGGGGDDDDVTSSGEPWRCPRCRNRTDVEIRTTSCQLCELRGGALIPCQIGTDSTWAHVACALFNRRAIFDCPNRPGACFVEPSPRQQSETPRMPPRRLSEEYRAELGDLYENSRWECVVCHRTDEGLAPCVLCIEEQATTSLPTLAHVTCARRVGFVCEVRDYPRGVVMICHKHEHSYLVNKTTQQQAYTNVKVGDFVFVEDVVEPPQKLFTRGAIVRADKKETVVVDFLDNSCSRDNHVEDIISCECLFCENGDHQYGARVKVVWDDKQVYDAYFRGKGQMIEYTVRLEDGREVRHPRNRLKTKRELNAYLKK
The following text describes a protein:
Function:
Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.
Sequence:
MKQDMSSADVAAVVAELSAGPRSIIDAKIGKIYQPASEEIRINLYVFHQGRDNLVIEAGKRLHMTKYVRASPTLPQAFPMLLRKYLMGGRIISVEQHDFDRIIKIGIERAGVRSTLIVELFARGNVLIVDSENKIILPMNPVTLKDRRLRSGEIYELPEAQLSPLEAKVSDLMEAFSKSTADIVRTIATRFNLGGVLAEEACVRAGVDKAKPAKEATVEDAEGLRDALQDLFSPLFIGRAAGEGKGEAEAGVGTEPATGVEAEAPKLRPQHVKKEINGKIETFDVVPFDLIRYSEFEKEYFDSFNTALDEFFGKKALEQVAEVKAAEKKEKTLGVYERRLLQQEESLAKFGKEIEKNNTLAEIVYANYQLIEELFSVLNGARAKGYSWDEIRSILKQAKKTVPAAQKITNIDQKTGTVTVDLDGRNVNLDIRKTVPQNAQEYYEKVKKFSKKRDGALKAIEETKKAMEKKAASKAAKAGRKLQAFRKKHWYDRFRWFVSSDGFLVVGGRDADTNEEIFKKYLEKRDIVFHTQTPGAPLTVVKTGGEEIPESTLLEVARFAVSYSSLWKSGQFSGDCYWIKAEQVTKTPESGEYLKKGAFVIRGERNYFKDIPLGVAVGLELKGETRVIGGPASAVRKHGDYILEIVPGKFNQNDISKKIYRTYADELGDPRFVKQIASPDQIAMMIPAGESDLRNQKPERKGQGTESEGEGYGISELGAEFEGGGEEAETEFGDEAGEEFEEEAGDEVGEGEETEIEMEVGEEEDVKIEKGAREEIETEIEIHGVKKV
The following text describes a protein:
Function:
Involved in DNA transformation; controls virE2 polymerization and prevents virE2 binding to DNA.
Miscellaneous:
MISCELLANEOUS: The Ti plasmid contains at least six transcriptional units, designated vir loci, which are essential for efficient crown-gall tumorigenesis.
Sequence:
MVIIKLNANKNMPVLAVEKPQEIHKEELSDHHQSNGFTSLDLEMIELENFVLHCPLPEENLAG
The following text describes a protein:
Function:
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, cilium. Cytoplasm. Golgi apparatus.
Sequence:
MPRTQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSGDKLAPLAVAGVGLVLDIILFVLCKKGLLPNRVTRRVVPYLLWLLISAQVFSYLGLNFSRAHAASDTVGWQAFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQDGLKGVQLLREENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGEGGSRCDYLEEKGIETYLIIASKPEVKKTAAQNGLNGSALLNGAPPSSKPSSPALIETKESNGSIHTSGSVSEEPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTAVVEILIDPWLMTNYVTFVVGEALLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVVDMLSCLQYYTGPTNGTAEMQVEDGCVENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLIAGAVAVINIYAWCPIFDDYDRKRFQQHDFPMVALEKMQVFSSSGLNGTDRLPLVPSKYSMTVMIFVMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFTSSNKDEKSDKERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGASITLPHQVVDNS
The following text describes a protein:
Function:
The maturation protein is required for the typical attachment of the phage to the side of the bacterial F-pili. Binds to sequences located toward each end of the genome, hence circularizing it. The RNA genome-maturation protein A complex is released from the capsid upon host receptor binding. Maturation protein A enters the cell along with the viral RNA.
Subcellular Localization:
Virion. Note=A single copy of the maturation protein is present in the virion and replaces a coat protein dimer at one of the icosahedral two-fold axes.
Sequence:
MRAFSTLDRENETFVPSVRVYADGETEDNSFSLKYRSNWTPGRFNSTGAKTKQWHYPSPYSRGALSVTSIDQGAYKRSGSSWGRPYEEKAGFGFSLDARSCYSLFPVSQNLTYIEVPQNVANRASTEVLQKVTQGNFNLGVALAEARSTASQLATQTIALVKAYTAARRGNWRQALRYLALNEDRKFRSKHVAGRWLELQFGWLPLMSDIQGAYEMLTKVHLQEFLPMRAVRQVGTNIKLDGRLSYPAANFQTTCNISRRIVIWFYINDARLAWLSSLGILNPLGIVWEKVPFSFVVDWLLPVGNMLEGLTAPVGCSYMSGTVTDVITGESIISVDAPYGWTVERQGTAKAQISAMHRGVQSVWPTTGAYVKSPFSMVHTLDALALIRQRLSR
The following text describes a protein:
Function:
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Subcellular Localization:
Cytoplasm.
Sequence:
MLRNKSQKELLHLSRQLIQPLLPNFHKGQAGKIVVIGGNEDYTGAPFFASHSAALVGADLSHVICEKAAGPVIKSYSPDLMIHPYLMDLDNPHLNLNNSELEKLKNLPIDEIIKTNDNAVLNKLIDELILPKVTSLLNRIDIVVVGPGFGRDPLMLKSLIRIIEEVKVLNLPIILDADSLYLVSLSPKIIANYPKAIITPNVVEFQRIAKALSIDADLSESNKDKLIDQTIEVSRKLGDIIVFRKGEHDLIVKSSKFLINEITGSNKRVGGQGDTLTGAIATLVNWSNNYILRLWDNQVVVNWSNNYILRLWDNQVDLDQEDANLLACFAASSVVRNASSKAFNKYGRSMQTSNVHEYLHESFTELFGDSIFRTSNI
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It prefers amino acid residues with hydrophobic side chains like leucine and phenylalanine in the P1 position of the peptides substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MARTAAALHILVKHKEQADDILAQLKKGAKFHVLAKKYSTCPSGKKGGDLGEFRQGQMVPAFDKACFQGEVLTPQLVKTKFGWHVVKVLYRT
The following text describes a protein:
Function:
Transcription activator, when associated with BHLH2/EGL3/MYC146 or BHLH12/MYC1. Involved in epidermal cell fate specification in leaves. Together with TTG1 and GL3, promotes trichome formation and endoreplication. Regulates the production of a signal that induces hair (trichome) precursor cells on leaf primordia to differentiate. Binds to the WER-binding sites (WBS) promoter regions and activates the transcription of target genes (By similarity).
Subcellular Localization:
Nucleus. Note=Detected in trichome nucleus.
Sequence:
MRIRRRDEKENQEYKKGLWTVEEDNILMDYVLNHGTGQWNRIVRKTGLKRCGKSCRLRWMNYLSPNVNKGNFTEQEEDLIIRLHKLLGNRWSLIAKRVPGRTDNQVKNYWNTHLSKKLVGDYSSAVKTTGEDDDSPPSLFITAATPSSCHHQQENIYENIAKSFNGVVSASYEDKPKQELAQKDVLMATTNDPSHYYGNNALWVHDDDFELSSLVMMNFASGDVEYCL
The following text describes a protein:
Function:
May be involved in signaling by recognizing appropriately phosphorylated substrates via its arrestin domains and then recruit a HECT-type ubiquitin ligase such as hulA, leading to ubiquitination of the substrate, providing a link between ubiquitination and phosphorylation in protein regulation and stability.
Sequence:
MALHRLKGHGANVGNRVGIQLDKDFVLFQGSEQEALAVYLSGILSLRLKETTTIKYIRLHLRGVRRVSSDTQSSLPARTGRKRFCSENEFYSRTWNFFDGYREAPMTVPAGEYKYPFDVVMEGSLPASVEGMKEASISYLFTVEIGRRHGRDITFDKPLRVIRVPDLEPCSHDFALDEVWANKIAYRIGIQNRTVALGTRIDVDYVFAPLLRDMKIAFIESQLLEVRDLSVEPNDGGSAHAARTETIVCSDRYTLGEEYSSKALESYQFSRTLQLPQALGHCVQDTEDMGVRVSHKLKIHVRMHNPDGHESELRLAIPVLIYLSPYYRVWEDSFCGETIPLPETLNPSDECPPAYGMHELDQLYMPQD
The following text describes a protein:
Function:
Involved in the regulation of nitrogen metabolism (By similarity). Regulates the activity of its targets by protein-protein interaction in response to the nitrogen status of the cell (By similarity). Regulates the activity of the ammonia channel Amt2 via direct interaction (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MKKVEAIIRPEKLEIVKKALSDAGYVGMTVSEVKGRGVQGGIVERYRGREYIVDLIPKVKIELVVKEEDVDNVIDIICENARTGNPGDGKIFVIPVERVVRVRTKEEGRDVL
The following text describes a protein:
Function:
Functions as an E3 ubiquitin ligase (By similarity). May be involved in the abscisic acid-mediated signaling pathway, at least during germination.
Subcellular Localization:
Nucleus. Cell membrane. Note=Relocates from nucleus to plasma membrane when phosphorylated.
Sequence:
MAKTGVFDSDPTAIAKAKELKREMKKLLIKIDDEDDLGVQTIDQLQDALSALREATMRKMAKSSSLEMLETVSCPEEFRCPLSNELMRDPVVLASGQTYDKLFIQKWLSSGNRTCPKTQQVLPHTALTPNLLIREMISKWCKKNGLETKSQYHPNLVNEDETVTRSDREIFNSLLCKVSSSNLQDQKSAAKELRLLTRKGTEFRALFGESPDEITRLVNPLLHGSNPDEKLQEDVVTTLLNISIHDDSNKKLVCENPNVIPLLIDALRRGTVATRSNAAAAIFTLSALDSNKVLIGKSGILKPLIDLLEEGNPLAIKDVAAAIFTLCIAHENRSRAVRDGAVRVLGKKISNGLYVDELLAILAMLVTHWKAVEELGELGGVSWLLKITRESECKRNKENAIVILHTICFSDRTKWKEIKEEENAHGTITKLSREGTSRAQRKANGILDRLRKAMNLTHTA
The following text describes a protein:
Function:
In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLDCLRLALLCALPWLLRAAVPGHQEEPLAKSAELRRDPRDPARGADFDRVYSGVVSLSTENIYSFNHTSHPGQVTAVRVHVNSSSDNLDYPVLVVVRQQKEVLSWQVPLLFQGLYQRSYNYQEVSRTLCPSKATNETGPLEQLIFVDVASMAPHGAHYKLLVTKIKHFQLPTNVAFYFTASPSQPQYFLYKFPEDVDSVIIKVVSEKAYPCSVVSVQNIMCPVYDLDHNVEFNGVYQSMTKKAAITLQKKDFPDEQFFVVFVIKPEDYACGGSFSIQENENQTWNLQRSKNLKVTIVPSIKESVYVKSSLFSIFVFLSFYLGCLLVVLVHHVRFQRKSIDGSFGSSDGSGNMAVSHPITASTPEGSNYGAIDESSSSPGRQMSSSDGGQPCHSDTDSSVEESDFDTMPDIESDKNVIRTKMFLYLSDLSRKDRRIVSKKYKIYFWNIITIAVFYALPVMQLVITYQTVVNVTGNQDICYYNFLCAHPLGVLSAFNNILSNLGHVLLGFLFLLIVLRRDLLHRRALEAKDIFAMEYGIPKHFGLFYAMGIALMMEGVLSACYHVCPNYSNFQFDTSFMYMIAGLCMLKLYQTRHPDINASAYSAYASFAVVITLTVLGVVFGKNDVWFWIIFSAIHILSSLALSTQIYYMGRFKIDLGIFRRAAMVFYTDCIQQCSRPLYMDRMVLLIVGNLVNWSFAFFGLIYRPRDFASYMLGIFICNLLLYLAFYIIMKLRSSEKVLPLPVFCIAATAVVWAAALYFFFQNLSSWEGTPAESREKNRECVLLDFFDDHDIWHFLSATALFFSFLVLLTLDDDLDVVRRDQIPVF
The following text describes a protein:
Function:
Transcription activator involved in oxidative stress response and redox homeostasis. Regulates the transcription of genes encoding antioxidant enzymes and components of the cellular thiol-reducing pathways, including the thioredoxin system (TRX2, TRR1), the glutaredoxin system (GSH1, GLR1), superoxide dismutase (SOD1, SOD2), glutathione peroxidase (GPX2), and thiol-specific peroxidases (TSA1, AHP1). The induction of some of these genes requires the cooperative action of both, YAP1 and SKN7. Preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Activity of the transcription factor is controlled through oxidation of specific cysteine residues resulting in the alteration of its subcellular location. Oxidative stress (as well as carbon stress, but not increased temperature, acidic pH, or ionic stress) induces nuclear accumulation and as a result YAP1 transcriptional activity. Activation by hydrogen peroxide or thiol-reactive chemicals elicit distinct adaptive gene responses. Nuclear export is restored when disulfide bonds are reduced by thioredoxin (TRX2), whose expression is controlled by YAP1, providing a mechanism for negative autoregulation. When overexpressed, YAP1 confers pleiotropic drug-resistance and increases cellular tolerance to cadmium, iron chelators and zinc.
Miscellaneous:
MISCELLANEOUS: One of 8 closely related fungi-specific YAP proteins (YAP1 to YAP8), which all seem to be transcription activators of the environmental stress response and metabolism control pathways and to have similar but not identical DNA binding specificities; MISCELLANEOUS: Present with 1600 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Oxidized YAP1 is found predominantly in the nucleus, while reduced YAP1 is continuously exported to the cytoplasm by CRM1/exportin 1. Nuclear import requires the karyopherin PSE1/KAP121 and is independent on YAP1 oxidation state.
Domain:
Contains two cysteine rich domains (CRD), referred to as the N- and C-terminal CRD's, n-CRD (Cys-303, Cys-310 and Cys-315) and c-CRD (Cys-598, Cys-620 and Cys-629), respectively. Cys-315 is not conserved in orthologs in other yeast species. A nuclear export signal is embedded in the c-CRD, with which the nuclear export protein CRM1/exportin 1 interacts only in the absence of disulfide bonds (or otherwise oxidized cysteines) within the c-CRD or between the c-CRD and the n-CRD.
Sequence:
MSVSTAKRSLDVVSPGSLAEFEGSKSRHDEIENEHRRTGTRDGEDSEQPKKKGSKTSKKQDLDPETKQKRTAQNRAAQRAFRERKERKMKELEKKVQSLESIQQQNEVEATFLRDQLITLVNELKKYRPETRNDSKVLEYLARRDPNLHFSKNNVNHSNSEPIDTPNDDIQENVKQKMNFTFQYPLDNDNDNDNSKNVGKQLPSPNDPSHSAPMPINQTQKKLSDATDSSSATLDSLSNSNDVLNNTPNSSTSMDWLDNVIYTNRFVSGDDGSNSKTKNLDSNMFSNDFNFENQFDEQVSEFCSKMNQVCGTRQCPIPKKPISALDKEVFASSSILSSNSPALTNTWESHSNITDNTPANVIATDATKYENSFSGFGRLGFDMSANHYVVNDNSTGSTDSTGSTGNKNKKNNNNSDDVLPFISESPFDMNQVTNFFSPGSTGIGNNAASNTNPSLLQSSKEDIPFINANLAFPDDNSTNIQLQPFSESQSQNKFDYDMFFRDSSKEGNNLFGEFLEDDDDDKKAANMSDDESSLIKNQLINEEPELPKQYLQSVPGNESEISQKNGSSLQNADKINNGNDNDNDNDVVPSKEGSLLRCSEIWDRITTHPKYSDIDVDGLCSELMAKAKCSERGVVINAEDVQLALNKHMN
The following text describes a protein:
Function:
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MADPLYSSLKTVNSTSKVTPESLVFQTKILTPEEAKNVINEKIAFKPLLLVPSLNLEKQGDRKESVASKKRKKLSSKEKKKLQLNVVPKIADYSQFKHLHSMWCSYILEVIAGCTGESLMAKLAKAEYQGAYMQVLRSKSTTRVGLEGICIHESKHMLSLITKENRVVRVPKQDSVMKVIVDVPQRKLVFELYTQHLLLRAGDRSNKRFKSKNTIDL
The following text describes a protein:
Function:
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
Sequence:
MSVMASDKACAPVRASRPFPKQKLRELVLQALYALEIDPEGEDSLVSLLMTEASVSKKNAAYALMFCRAIRANQPDLDALLDATIRTTTLARLTIIERNILRMMLFEHQQNQDCCPVPVAVLIAETTRLIKKFSYSEGSSLILAVLGSIFDHPAPALDAPLEPTSMCG
The following text describes a protein:
Function:
Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity. A Cbi(MN) fusion protein has about 70% import capacity, but the holo-Cbi(MN)QO complex cannot be isolated, suggesting CbiN may destabilize it.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSSKRTLWLLAGTVALVVVPLLMGGEFGGADGQAAELIEATVPGFAPWADPLWEPPSGEVESLFFALQAALGAFVVGLVIGRRQGAAKTREQNAPAPRSFPAE
The following text describes a protein:
Function:
Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster.
Subcellular Localization:
Cytoplasm, nucleoid.
Sequence:
MFRGATLVNLDSKGRLTVPTRYREQLIESATGQMVCTIDIHHPCLLLYPLPEWEIIEQKLSRLSSMNPVERRVQRLLLGHASECQMDGAGRLLIAPVLRQHAGLTKEVMLVGQFNKFELWDETTWYQQVKEDIDAEQSATETLSERLQDLSL
The following text describes a protein:
Function:
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation.
Subcellular Localization:
Lysosome.
Sequence:
MIWEVAVLLSLVLGVGALPMDDPEDGGKHWVVIVAGSNGWFNYRHQADVCHAYQIVHRNGIPDEQVIVMMYDDIAYSEENPTPGIVINRPNGSDVYAGVPKDYTGKDVNPQNFLAVLKGDSEAVKGKGSGKVLKSGPKDHVFVYFTDHGATGILCFPDDDLHVQDLNQTIYFMYQHKMYRKLVFYIEACESGSMMHHLPADINVYATTASNPSESSYACYYDDERVTYLGDWYSVNWMEDSDMEDLTKETLHKQYQLVKSHTNTSHVMQYGNKSISAMKVVEFQGVKHKASSPISLPPVKRLDLTPSPDVPLAILKRRLMSTNDLQESRHLAEDIRRHLEARHVIEKSVRKIVSVVARSDAEAERLLSERAPLTAHDCYRAAVSHFRTYCFNWHSPMYEYALRHLYVLVNLCEQPYPVDRIKSSMDKVCLDNY
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSSQPYYNADGNPPVVQGTVLHNTNHNNAHIYDHQHAGHGVGAMEIADPSQSQQFHQQQEQPHEGGNWTKGEHQPRRCNDAIFAVLFYVHLGVMGWVAGTFAPRMFAEVAASNGMNNQRDLVEDGGGTSDSSGMTSRVFRLMIQSVHSLGYGALSASDRSLQEENNYADVTGTNDFDDMLLLLGITGMVALVISTLALSFMIRHAEIMIKFALLFNIAASAVVRLMFTRQSAPILTNRHVSTIQFTIGSLFLSPFAAIWGMFLTGIMVYYAYVVWGRIPFAACKIHTATTAVKANLGLAFLAYSSLVILLGWSAWWMVGFVSTVYITSGCDGQGNCEGETNGAVTFALMLSYYWTSSVIRNVVHVTVAGTVGTWWFVPSEASTCCSSAVRDSYVRSVTTSFGSICMGSLIVAFVQALKNMVHNARRNGDGLFLCVAECIMSCLQNVIEYFNVWAYVFVGIYGYTFLESGKNVINLFKTRGWTTIITDTLAGSVLGMLSGGVGLITGLISLAIAHGQGMVFGNEVGASAAAFFVGFIFGAALTSTFMTLVGSAVNTVIVCFAEAPQEFRVNHPKLSEEMHAAWTKAWPDEYRG
The following text describes a protein:
Function:
Regulator of RNA-directed DNA methylation (RdDM). Binds to single-stranded methyl DNA. Involved in the assembly of RNA polymerase V (Pol V) transcription initiation or elongation complexes at the chromatin, as a component of the DDR complex.
Subcellular Localization:
Nucleus, nucleoplasm. Note=Peri-nucleolar.
Sequence:
MQSSMTMELRPSGDSGSSDVDAEISDGFSPLDTSHRDVADEGSLLRRAEMYQDYMKQVPIPTNRGSLIPFTSWVGLSISMKQLYGQPLHYLTNVLLQRWDQSRFGTDSEEQRLDSIIHPTKAEATIWLVEEIHRLTPSHLHMALLWRSDPMYHSFIDPIFPEK
The following text describes a protein:
Function:
As part of the purine salvage pathway, catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Preferentially acts on inosine and guanosine, and to a lesser extent on 2'-deoxyinosine and 2'-deoxyguanosine.
Sequence:
MEGEMQRHIKLTKAQTTPVVLVVGDPGRVDKVKVLCDSYVDLAYNREYKSVECTYKGQKFLCVSHGVGSAGCAICFEELMNNGAKVIIRAGSCGSLQPTQMKRGDICICNAAVREDRVSHLMIYSDFPAVADYEVYATLNQVAEELKVPVFNGISLSSDMYYPHKIIPTRLEDYSKANVAVVEMEVATLMVMGTLRKVKTGGIFIVDGCPLKWDEGDFDNNLVPERLENMIKISLETCARLAKKY
The following text describes a protein:
Function:
Transcription activator that binds calmodulin in a calcium-dependent manner in vitro. Binds to the DNA consensus sequence 5'-[ACG]CGCG[GTC]-3' (By similarity). Regulates transcriptional activity in response to calcium signals (Probable). Involved in freezing tolerance. Involved in freezing tolerance in association with CAMTA2 and CAMTA3. Contributes together with CAMTA2 and CAMTA3 to the positive regulation of the cold-induced expression of DREB1A/CBF3, DREB1B/CBF1 and DREB1C/CBF2. Involved in drought stress responses by regulating several drought-responsive genes. Involved in auxin signaling and responses to abiotic stresses. Activates the expression of the V-PPase proton pump AVP1 in pollen.
Subcellular Localization:
Nucleus.
Domain:
The two IQ domains are probably not interacting with calcium/calmodulin.
Sequence:
MVDRRSFGSITPPLQLDMEQLLSEAQHRWLRPTEICEILQNYHKFHIASESPTRPASGSLFLFDRKVLRYFRKDGHNWRKKKDGKTIREAHEKLKVGSIDVLHCYYAHGEANENFQRRCYWMLEQHLMHIVFVHYLEVKGNRTSIGMKENNSNSVNGTASVNIDSTASPTSTLSSLCEDADTGDSQQASSVLRPSPEPQTGNRYGWTPAPGMRNVSQVHGNRVRESDSQRLVDVRALDTVGNSLTRFHDQPYCNNLLTQMQPSNTDSMLVEENSEKGGRLKAEHIRNPLQTQFNWQDDTDLALFEQSAQDNFETFSSLLGSENLQPFGISYQAPPSNMDSEYMPVMKILRRSEDSLKKVDSFSKWAIKELGEMEDLQMQSSRGDIAWTTVECETAAAGISLSPSLSEDQRFTIVDFWPKSAKTDAEVEVMVIGTFLLSPQEVTKYNWSCMFGEVEVPAEILVDGVLCCHAPPHTAGHVPFYVTCSNRFACSEVREFDFLSGSTQKINATDVYGTYTNEASLQLRFEKMLAHRDFVHEHHIFEDVGDKRRQISKIMLLKEEKEYLLPGTYQRDSTKQEPKGQLFRELFEEELYIWLIHKVTEEGKGPNILDEDGQGILHFVAALGYDWAIKPVLAAGVNINFRDANGWSALHWAAFSGREETVAVLVSLGADAGALTDPSPELPLGKTAADLAYANGHRGISGFLAESSLTSYLEKLTVDSKENSPANSCGEKAVQTVSERTAAPMTYGDVPEKLSLKDSLTAVRNATQAADRLHQVFRMQSFQRKQLCDIGDDEKIDISDQLAVSFAASKTKNPGQGDVSLSCAATHIQKKYRGWKKRKEFLLIRQRIVKIQAHVRGHQVRKQYRTVIWSVGLLEKIILRWRRKGNGLRGFKRNAVAKTVEPEPPVSAICPRIPQEDEYDYLKEGRKQTEERLQKALTRVKSMVQYPEARDQYRRLLTVVEGFRENEASSSASINNKEEEAVNCEEDDFIDIESLLNDDTLMMSISP
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MQVPTHSNIQGSQSFSLTKNLMMPCSMKHSGLQLQDQDSSSTQSTEESGGGYIVSPAGKAIASYTKSATTSSMVSHDSVFPPPPPTYFNGFLAPEYASQPTVLPHVEMMGLFTSRVPLPHNYQESEPMFVNAKQYHAILRRRKHRAKLEAQNKLIKSRKPYLHESRHLHALKRARGSGGRFLNTKKLQESSSNSLCSSSVTPSSSSDRDNMFQNPTFRFSGYPSTHHVSALMSGT
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes at the cell tip and barrier septum.
Sequence:
MPRRAVLFRGNSFISFSSISSGNESSAHGDASLGQADKPLTVDVLDAWTTQFTKKQTRVFHEAYVSAYIDLQQKYARLERLQEQILNLERSLLNYKSLKSNSTTTVATVPSEKRYFFRRKPKTSSTTNSLSSSSSSVSHMNQDANPNSTVLTFTAVPYDSCLPAPDRHTPSSASSRASETGTTSPQSMRNQISLLYSKVDQVKTEIASAQAVMHDLLRTYPGSESLQQSTHTQF
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system SiaPQM that catalyzes unidirectional Na(+)-dependent sialic acid uptake.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MVGSIFGWLGLLFAGMPVGFSLIFVALAFLILTNSTGINFAAQQMLGGIDNFTLLAVPFFVLTGHLMNSAGITERIFNFAKSLVGHITGSLGHVNIMASLLFSGMSGSALADAGGLGQLEIKSMRDAKYHDDFAGGLTAASCIIGPLVPPSVPLVIYGVVSNTSIGALFLAGAIPGLLCCIALMVMSYFICKKRGYMTLPKASRREQFKSLKEAFLSLLTPVIIIGGIFSGKFTPTEAAAVSSLYALFLGTVVYNTLTLQGFIEILKETVNTTAVVALMVMGVTVFGWIVAREQLPQMLADYFLTISDNPLVLLLLINLLLLFLGTFIESLALLLLLVPFLVPVASAVGIDPVHFGVMAILNLMIGILTPPMGMALYVVSRVGDIPFHTLTRGVLPLLVPLFIVLALVAVFPQFTLLLPELFLGYGQ
The following text describes a protein:
Function:
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
Subcellular Localization:
Nucleus.
Sequence:
MGVEYEVTRIKKQLEKALNREIVDNEFILDLLTNLKDLKMTLEILQKTRVGYHVNNVRKKADKEVVINLAKSLIKDWKRLLPDSKKNEAKDKTDSRQMDKDSQDLIQQSEINPSLMVEEKDNTTVHQSHNNDKDMQVLSSGNPTRDLSRKLLIGALSRDGLNKAIFKELKGPNMKYKNRVRSRISNLKDSKNPNLCQKVLSGIITPEQIAKMTAEEMASDEMKKLRQGYAKEGIRDAQMAVTQGTKTDLLTCGKCHKKNCSYNQMQTRSADEPMTTFVFCHECGHRWKLLVSSYMSLFGIVT