lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.
Sequence:
MEFTDIAMELSKKAWQASFHHPFILQLQEGNLEPAIFRYYLIQDAYYLKAFSEIYHLLADKTSNQEMKRLLKQNAQGLVEGELFIRQQFFKELEISDQEMEQHPIAPTCYHYISHIYRQFAEPNLAIAFASLLPCPWLYHDIGKSLNLKPSPNPLYQQWIETYITDELEQQIREEGALVNQLYRESDETDKQKMLDTFHISVHMEAKFWEMAYQHQTWKSDLQSLEKGEE
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MLNNIKHYAQTVTKLSDHDDSSIDRLNYVITTSILLGFSLLLFAKNYVGEPMQCWTPNQFNDGWESFAEQYCFIENTYFVPMQDSNLPAADTREDREMIYYQWVPFLLIIQALFFCIPRAYWIIFPSYTGLTIADMITAARKNGKQLESADKALEQVALVNWRAEQQKGHNGSRIFNCYLIMKLLILINIILQFFLLNSFLNTAYTFWGWGIFWDMFHGRHWQESGHFPRVSFCDINVRELGNVHHWSLQCVLMVNMFNEKIFIFLWFWFAFLLIATTFDFIIWVWRRFDKQSRIGFILDLLNQEGIDHSPQKANELYHNVLRDDGVLFLRLLDSNSGRLNSEELMKKIYNLSVGTHAPHASIDSESDSNQQRS
The following text describes a protein:
Function:
[Gasdermin-C]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering pyroptosis; [Gasdermin-C, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis. Produced by the cleavage of gasdermin-C by caspase CASP8 in response to death signals. After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis.
Subcellular Localization:
[Gasdermin-C]: Cytoplasm, cytosol; [Gasdermin-C, N-terminal]: Cell membrane; Multi-pass membrane protein.
Domain:
Intramolecular interactions between N- and C-terminal domains are important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain.
Sequence:
MSYTFDWLSKDVVKKLQGRDLRPVKCLSDATKFCLFNILQETSSRLALKTEYIPVGFTLLHLLEPNIPVPEPEVSAPIPLKHTISQKLKADLDVETIAGGEAGFVKSCGYDIEVQSKSIPNPKLESLQNRKLLDQLPTFMKTCWKDGKNLYVVTEAYEVTKDTVLEGTSNSKFAIKGIINQLVKVGGSGQWQTEKTDSIPIQKGSVLAYKKQQLVIEDNTCVILTSANTKKKMTFPMRFVGMSGHLRYQDLVIETGSWINDIDPIGTIKEPTHLDFMCLQNEVSEQTRLLAELSKDVQEVVFSSFLHMLCDRDVLYDLMKMLELNQLGHMDGPGGKILDELRKDSSLSWINLKDLILYLLQALMVLSDTQLCLLALSVEMRLLPHQVELVKSILQPNFKYPWNIPFTLQPQLLAPLQGEGLAITYELLEECGLKMELNNPRSTWDLEAKMPLSALYGSLSFLQQLSEA
The following text describes a protein:
Function:
Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Might be shuttling between the nucleus and the cytoplasm.
Sequence:
MCLAGCTPRKAAAPGRGALPRARLPRTAPAAATMFQPAAKRGFTIESLVAKDGGTGGGTGGGGAGSHLLAAAASEEPLRPTALNYPHPSAAEAAFVSGFPAAAAAGAGRSLYGGPELVFPEAMNHPALTVHPAHQLGASPLQPPHSFFGAQHRDPLHFYPWVLRNRFFGHRFQASDVPQDGLLLHGPFARKPKRIRTAFSPSQLLRLERAFEKNHYVVGAERKQLAGSLSLSETQVKVWFQNRRTKYKRQKLEEEGPESEQKKKGSHHINRWRIATKQANGEDIDVTSND
The following text describes a protein:
Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKIETFMEEYWEKQPIVISNREKHRDYFQSLFTRTILEGLVAEKKISFIQDCNVCRYKGEVRESLNGNGIVKPTKLKELLDQDKATIQFHQPQRFQESVWNLLEKLESYFGCLVGSNIYMTPKLSQGLAPHYDDVEVFVLQLEGEKHWRLYKPPTLLPRDYSRDLDQSELGEPTHDIVLKAGDLMYFPRGTVHQADTPSTCSHSTHLTISTYQRSSWGDLLSIALPSMIQTAISENVSYRQGLPLRFVSDPNHQASSSETGRKMADLISQLSSHIESHGQEAANEMLCDFIANRLPPFCDGETDLAPRGPMPSSDQQVRLRFPDHTFIVKRQSEEDEEEEDEEEEEDDEEEDEDEDEKEFQVFVYHSLHNSHLEHMMCSEPKEALGIQLPRECEPALRALQECPQSWRNVSDISQDDAGSQMIMSLWAEGLVEIRDTEESL
The following text describes a protein:
Function:
Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MKLCANNVSYSYPDGTKAIEDVSLCISSGEIVCLLGPNGSGKSTLLLLLAGLIKPTSGSITIDGENLGRDYRKICGILFQNPSDQLIAPTVGEDVSLGPRQLKLEHQEIERRVKGALEALELLGFEDRSPFRLSGGEIARVALAGLIALDPEVYLLDEPSSSLDLKGMEALMEILRKLKERGKIVVIATQDSDLASEVADKVYIFNKGKLISGGRVNILYEAPLEEIGVKAPATVKICKELSHFLSECPLRMDDLINALKRALSSSRD
The following text describes a protein:
Function:
Carrier protein that may be involved in membrane-trafficking events associated with cell plate formation during cytokinesis. Binds to some hydrophobic molecules such as phosphoinositides and promotes their transfer between the different cellular sites (By similarity).
Miscellaneous:
MISCELLANEOUS: 'Patella' means 'small plate' in Latin.
Subcellular Localization:
Membrane; Peripheral membrane protein. Cytoplasm. Note=Mainly membrane-associated. Also cytoplasmic (By similarity).
Sequence:
MAQEEIQKPTASVPVVKEETPAPVKEVEVPVTTEKAVAAPAPEATEEKVVSEVAVPETEVTAVKEEEVATGKEILQSESFKEEGYLASELQEAEKNALAELKELVREALNKREFTAPPPPPAPVKEEKVEEKKTEETEEKKEEVKTEEKSLEAETKEEEKSAAPATVETKKEEILAAPAPIVAETKKEETPVAPAPVETKPAAPVVAETKKEEILPAAPVTTETKVEEKVVPVETTPAAPVTTETKEEEKAAPVTTETKEEEKAAPGETKKEEKATASTQVKRASKFIKDIFVSVTTSEKKKEEEKPAVVTIEKAFAADQEEETKTVEAVEESIVSITLPETAAYVEPEEVSIWGIPLLEDERSDVILLKFLRARDFKVKEAFTMLKNTVQWRKENKIDDLVSEDLEGSEFEKLVFTHGVDKQGHVVIYSSYGEFQNKEIFSDKEKLSKFLKWRIQFQEKCVRSLDFSPEAKSSFVFVSDFRNAPGLGQRALWQFIKRAVKQFEDNYPEFVAKELFINVPWWYIPYYKTFGSIITSPRTRSKMVLSGPSKSAETIFKYVAPEVVPVKYGGLSKDSPFTVEDGVTEAVVKSTSKYTIDLPATEGSTLSWELRVLGADVSYGAQFEPSNEASYTVIVSKNRKVGLTDEPVITDSFKASEAGKVVITIDNQTFKKKKVLYRSKTQA
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLLKLRLKEEQALALPDIYRQAPKDDPRALLEAANFADLVGVVRQLGELSDYAAVMFSQLHAETSRLGARGEAMAARASALEESMPEAEIRVFTAQDTRQLLPNDGLKWHSSPHEDQTLFTSSELPPYISEAYMKAQPPPPLHMLDRFDRTASDGGALRRYSDPYFFKREWALAELAQAEREKKAMKARRKAKHLGQQRSLRDLNEGAYVRQASRSRRNSRSNSQKAAATPPPQRPAPAELPEQPQRYSVYVPDEPKTPDSQRYSVYVPGDSKTRSEGDPPTPASQGTISPYVESSFASLGDASRSVPQVPHFKNAERELKAPANGLRTGVAQDEIVAIGKVNEVAKTAGYLVEANGESSGREAEQDAQEPRRERTASRDVAEDSPAAKNVPEPDKVHREGESALFDQRTGPDEAVTSNGRTASQTQAIPRARRRSTKARRETPRKSDGETENAFPRAESFDSVTQAARVREQIRREAEGALANERSETRGAAGLVDERGGVEASVAEASVGKLSDLEAEWVASACDGEGRPQEESGKVAQEEPSGVGERSPADHADVIRGVSKDVSEEQVAPAAKHKEENGRLAAWASVPGSPVVGEDSAPGSPMNPGLVKLQQEYQQAQARLEALLRMQKELEEQAHPPETGAAVALGTVSSATSLAVELSRSSGGAGPADDSPPETVDIDSPPWSQASSPPLHEPGQLRRFMDSPARPIRHSRSVLDSPGPAFAPSGRGALRMGSSSRLSPPRELSPGGFSSPPFSSPERSSPLRRPWVMQTPPRPETEDEYRPSGLSTQTSLPKDRSTNGGGAAEPRGLAGPVPPTAKSAPKPPPPPPPGSLGAFKKPSQSAPPPPPPPLAPGALTITGPSSSRGGAARPVDLMQAIAQHDKGKLKRVDERSGGVAAPTGDRNVMLEQIKKGVNLRRTETVKAEEKPSRPVTDINVASILERANAIRQAMQDSDDDEEDEDEEDDWLD
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Responsible for the transfer of the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MYYIGHPSYYRKHIEHVCFQHSGILKKRNYQKNQKKYIMKLNESAMKNAEKKSNSYLAIRMTRSGYNYFKGICVCTFLLSTILYLGIAVIMSHLCVFDDTAMLYLRQNRSRLAESNIFRTLFISWIRWDAIYFVDMAVNGSLFEQEWAFSSLWPKIISFLAFRSKDVVLLGIVSCFASIFFHAIACYALYLLTKSIFSNQKMTAYTVIFYCFSPSGIYMSVGYTESLFAAFSFLGLLLFIKKQQYPAAFLWSLATLIRSNGIFWCIFFGMPAIGTLKISLERLQLTFMQVSQLVGYGTKCLIILVPFFYNQYLGFKLFCPGVAWCNKSLPLIYPAVQEKYWNVGFLRYWTLNNIPNFLFALLSIIPILFALFYSISGSTLHSFRSIKSHLVLSALYLYIGCFHMHTQVLNRMSSALPLLYWSMAHATLYAKSRNLKAFGHCILFVWIVYTVIQAGLYGSFLPPA
The following text describes a protein:
Function:
Receptor tyrosine kinase which may be involved, downstream of pvf-1, in the positioning of ray 1, the most anterior ray sensillum in the male tail.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MRVSLTEFLVLAQVVTTLQPITIKVDFHEVKHHESIGDYVELVEGKNRDISLTCYGQHKNLKIEPPKREEHAGFPEIGIRTSAEWKKNEYWFLLKNVRQCDTGSYYCVSDEFKESMLQNTVHIFVRKLDIFVPLKTIYHEHNGSEIIIPCKTTKFVDTKNVELYVNQVKLNSALQGYDQRYGFKLTKNMYTMKPNSTVFFECKYTNDSNQDLDYYISNSDPDATLIDQYFFYWEKSNDVPYVGNNYSITCHLVYIGSDSLRPLNHQEIVLECPQNQCDGGYNNQSAHEIEKRSSGLRFGDPSSQDIVEKNTMLRYDRLSVYDRKTSRTVNFQNLTSEDSGIYRCTWRNRSKTNIVLDYDLNFNQKGTQIKIIETSKQRLKMRKNESTLLFVKFAVFPINKKNYTAKWSRLYNSTVEGGQQVETIRNGFFRQITTKTSGRNVFLETLNLKSPKIEMSGIYVLSISNMDIVQQVKWIIEVENDEPNAQLTIRDPLTLNISNQLFLPLNTNLSIFCLAVSSSPTDVIFEYRTDENEWFRGFYKNKLRKIDDTFEKGFIYNFVLAKRTDFKCINVKKKKTSTKFITVTSNANKTFHEIEKSVNATKTEPSDIIFEGDNVRLTCVVPYGAVEFDVFWKFENPKMLKYTTFPAMHPVKDRYKRVILNVRNITIDFTGTYYCIVKNKEFEHRFETSISVEKVSPPFLLNNNSRSIISASNGQMFDINCKVNGVPTPDYTWFKDGYPYTKGKVIGNALHVSKAEKRDNGIFWCSATNRAGTTIDYIEVKVAGASSSSFFWLFITFFAFVVVGIVVSLLWKLFGQKDLKPSELSLNNLKRATDEYQKYTVSEKINNLPVEERIDYLTYNEDYEIDLENLEILETLGSGQFGIVKKGYLNMASSKNFGFESRLSVAIKSSTDSSNMELQKMFFEELKLMCAIPKHPNVLSLVGAVTKNMEIGELFIVTELIDGGNLREFLRERRDVFANELVEKGYIFLTNVRENVPKREVEKEQLLIDEFNSLCTSDLLSIGLQIANGMDWLANIPCVHRDLACRNVLISKTKIIRIADFGLAKKHTDKAYYRVRESLDTPLPVRWMPLESITDLTFTQKSDVWSYGICLYEIFTLGGTPYPDCPNFSLVEYIKTGNINKRPSNCHKDVYKIMKMCWQASPDDRPTFAECIKLFKNHIQYFASKLLQQIEKDLECEKNNQQKFHYWVQKPTQLFF
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
Subcellular Localization:
Cytoplasm.
Sequence:
MIEQLLAAARVRGYITHADILATFPNPEHDIAEIDQLYAMLQAEGIKVIESSDELDGPTDFEPDPDADLIADLPDLGDIAFDDPVRMYLQEIGQVPLLTAEQEVELAKAMEAGAAARQRLDREEYTSARERFELERAVQQGQDARHHLIQANLRLVVSIAKKYTSYGLTMMDLVQEGNIGLMRAVEKFDYKKGHKFSTYATWWIRQAITRAIADQSRTIRLPVHMGEAISQVKRTSHRLQQTMQREPTPEEIADAMGISAGKVRRTLEASMHPLSLEMPVGQEGEGRMGDFIEDDRISTPAEAAAASLLREQLEEVLMKLPERERKIIQLRYGLKDGRYRTLEEVGIEFGITRERIRQIEAVALRKLRHPHLGKKLRGYLD
The following text describes a protein:
Function:
Functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation modifying cytidine to N4-acetylcytidine (ac4C).
Sequence:
MADRKRKKGYWRGARKRQRMSLEVGMKGILITCNKNEKACVREAYNLLNEYADQMYGPEITPSDSGSESEEEDVEAALAKEVAQMKEKSGKDKRRFQAMDSGANNVVFIQSQLESPDKLVHHILDDINASKKFKTRNVLRMIPVMSACKAYLENVKKSAEEMFPKFFSGEDNPSYAIVFKTRNSGTMKRDEVIKALAGVVSEVNPACKVNLNSPDLAIVIEVIRTVCCMSVLKDYFLLKKYNIHSIVEGTKDDPKPREVKDQGAPKGDLEAANGSDGQEDKGDVKVQETKAEGDSGASDKNNSGVKVKDDVPVVDNDVTSQGSKVVETDAEGQQTNKEVEATKE
The following text describes a protein:
Function:
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
Sequence:
MQVYKGRRGDEESIQRDCKKKEDFSSLSCINFLAVFLQTQISRRPSTQSSKMNAAAAAAGEDKAASSEFQQKESRQFKSKAPKPGQKRFDSSLPGMESFDDSAVVCPWEEFGDADLSELAQFGII
The following text describes a protein:
Function:
Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.
Sequence:
MKFLSNLFKKKIGSVEDILSHPDGKRYYRDAHLIRKNMIDEDAVKIIHRLNKFGFKAYIVGGGVRDLLLGRKPKDFDVVTNATPNQIKKIFNNCRIIGRRFKIVHILFRGKVIEVSTFRSLPDYRLGKAVEDQDYLIKRDNKFGTPQEDAARRDFTINSLYYDVRNDSIIDYVGGFEDIRNKVLRVIGDPDISFREDPVRMLRAVKFAEILGLNIEKTTAKAIRKHKTELEKASSSRMLEEYNKIFRTWKTSLIFQGMAEHGILEVLFKEAFDKERKKNSNFGEKFLETNIGKRLAIADKLLTEREEMTPHIFYSLIFSDLASEALQKENMHLVPAIKNSLELIFRRLETPKKDKDRLIKIFASQQRFLSTEDEKSSQNNFFRMKDYFYDAFMVFKIGAIAENDEKAIQSAFFWEISVRKRPTPVKKFNGARPNKSRNRNFQKNREEDRSNRREETQSSSESEKQNRKNQKENSQEDFSSEDSGNEF
The following text describes a protein:
Function:
Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MQRRTRGIDTGLLLLLSQVFHIGINNIPPVTLATLAVNVWFFLNPWKPLYHSCISVEKCYQQNDWQRLLLSPVHHGDDWHLYFNMVSMLWKGVKLEKRLGSRWFAYIIATFSLLTGVVYLLLQFASAELMNQPDFKRNCAVGFSGVLFALKVLSNHYCPGGFVNILGFPVPNRFACWAELAAIHFCTPGTSFAGHLAGILVGLMYTQGPLKKIMDACAGIFISNAGSSGQQYHFNNAGPSGYQNRYTDGRPVNYEATYRNYDIYTAGLSEEEQLERALRASIWDRGNTRNGPIPYGFRLPPEEEMRRQRLHRFDGQ
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MPPIEYANASQNSVMFGNVVPLSTLMEFLIQRTYHELSILSELLLGKNDLERKIEICQFANRTKQTFVRLLALVKWTNSANKVDKCARIFSFLQQQQLLFVETADCLARMARETLVHARLPSFSLPCAIDVLMTGTYPRLPFCIKEKIVPPEPLPPLEKKRVLTKLTQVIEYRIVMNDLPHSMCKPVIENGRVKFTVDHEFEVFLTLMGDTPNLPWRLLNIDILVEDYESKNGRSLVHPQQVAFIHEMVQSKLLESEQPLHDLYNCLLSTVTNFLFPDFFCQSLQLEVLYFQSFTLIKEKFGDFVKVDEYNLGRNLIISYWRDSGKSQKLYPTGCKLNIYVDEKNTSKPLFISHSPVLYGEDGMKSMKQINELKRELEMFTSAKCSIIDFPPLMYLTVSKELEEIIITVDMMKGLFSVTKINSANPYLDALEDSLNGDRKDIGQIFAAIRVFQYKCMYESMLVSHRLQYTDYSQKPTDLHATFGKNFFSVAFPNTNKYTMIIKFSNKDKACVQHFLLKVREMDPVSKRLNYSEMIFVDPAKILESNSINALLNSKKSKASVPLMHMFSNIYSHMEDIILFDGLNDELGLLGIYNSNHLPDPCGIGYSLQITKGISFDTSDAAKIPFNSHDMTVTFRLIKKDKCYWCVLVTASENPIFSLPTLNEQYTRCFLKVYDVSDVKKVVSSFATDWNVNYQMLKIVHDMSYQYNDHLVQGEQTLPSQFYIESFSFNKLVISYGPKRHFLVSVEYCNNTKSFQVTFGSHADSVISNPHSLVSAHLSHHLNKSKSLVLFCKLLAQTCEVNEQLYKLNTTPLVWTKVNWMLPVQNYTVVAQSLFHYRIYYFYPLFCMELSCPNKTYITFKDSSISPNAKLNDASLSGFQAFLCASSDSLCSSNDVTGSIDENNAQHNVVGMSDVDNFLLSDLQMNVFRSAAEKIHQPFLENYVTRDLLTKLMTPINNVSPLDKYLGVQYFRRHLQRIIKSDDSQLIQIPTTEAGVLMFKSDLSGLQLKFNASLVSSPLKIFPLQDTPWDMDDLFSLEKFFEVKVLSHPYKPSNLEAFCSLLKMHFHILKDFINIFRMELNADKNMRWFVQLLLTFPSGFDYNMGANAIVISRKIVFILLLTCNVGHPSYAESTPSSNQPPNVILPLCYDSATNTVQLVENHKQNVNQMSVVANILKRFSDFLVKPNECSILPAIREIIANLT
The following text describes a protein:
Function:
Has a role in the regulation of G2/M transition during the mitotic cell cycle.
Subcellular Localization:
Cytoplasm. Barrier septum. Forespore membrane. Ascus epiplasm.
Sequence:
MSILAGFKNLLKHSKSSKGRSNASKSVDVSVNRDVAAYTELAAKNVNAGGDEEIRVANYPGLEKYQLIENLGDGAFSQVYKAYSIDRKEHVAVKVIRKYEMNKKQRQGVFKEVNIMRRVKHKNVVNLFDFVETEDFYHLVMELAEGGELFHQIVNFTYFSENLARHIIIQVAEAVKHLHDVCGIVHRDIKPENLLFQPIEYLPSQNYTPPSLEPNKLDEGMFLEGIGAGGIGRILIADFGFSKVVWNSKTATPCGTVGYAAPEIVNDELYSKNVDMWAMGCVLHTMLCGFPPFFDENIKDLASKVVNGEFEFLSPWWDDISDSAKDLITHLLTVDPRERYDIHQFFQHPWIKGESKMPENFTYKPKLHGTPGGPKLSLPRSLVSKGEIDIPTTPIKSATHPLLSSYSEPKTPGVSSVHEAMGVAYDIRRLNHLGFSPEQLSKKSMNTGSIKELILDEETTTDDDDYIISSFPLNDTLGSEGKDPFSLNLKESSLYSRRSAKRVN
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MYDPGRFIFPMRFSMWAWKVCGFFNAPVPKSVAYRVYCYAFYSCIMAVYLFVLLLNVFVPQPFEQRVFFIMYIFLTETAMILKTLTIYRHFNIVWSLYETTLGVSFQPRDEQERELQQRRLAVFNRWYYAYIFVSHMAAFGTGSHLLSAEYRMPFFPWFFGVPYWEDAHVAYYTIFAYQSFGMYFHMLLNTAGDTQLCYMMHMIGIQLELLGKRFRDLNNCEEFDRSFVPLVQHYNKIHRMLCRVQNLFSPAYFVQFSVSGLVICASAYQVASMLNLNDFSKLMNVFYMMSMTMQIGLPCYYGNEVTLKSYALTNAIYSSRWYDMPQSNRKSVQMFLVRTNKPFAVAAFGYFNFNLPAFTTILNMAYSVYCVLQRKAKNV
The following text describes a protein:
Function:
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAPKGSSKQQSEEDLLLQDFSRNLSAKSSALFFGNAFIVSAIPIWLYWRIWHMDLIQSAVLYSVMTLVSTYLVAFAYKNVKFVLKHKVAQKREDAVSKEVTRKLSEADNRKMSRKEKDERILWKKNEVADYEATTFSIFYNNTLFLVVVIVASFFILKNFNPTVNYILSISASSGLIALLSTGSK
The following text describes a protein:
Function:
Involved in sperm capacitation and acrosome reaction.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome.
Sequence:
MGEEQQKPEELNAPTDDAPQEKQQPADLSSETEKAKSKKKQELSEKDQVVKIQAWWRGTLVRRSLLHAALSAWIIQCWWRLILPKIMEKRRQSMLDTFQQEQWAVVRLQSWIRMWRIRRRYCRLLKAVRTIQSHWRGHTCSSRGVIKGQYRISTSQMHLELEVLLGSGPCIVTECIPLPIKQ
The following text describes a protein:
Function:
Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR.
Subcellular Localization:
Nucleus.
Sequence:
MAALSGGGDGAESSSGKLKSPQVTPQKVRELLNDGIALEDNRLDSEEQVVEPEAPNGITHLPCEATSKEGFFSRVETYTSLKWAGKPHDLSPLRCARYGWTNVECDMLKCPSCQAFLCASLQPTQDLQKYKERISELKKSLQMHHEKFCFWPDFPSPDRFWTLPISEPAVLFRAFLDRFKSACLLELQLPSMKPDDLKNMSLTEDAVGDLLQLIEDEVKKEGGSPLKMSTDPLPVQVAACIVALCGWAASPALDSLHLPVLACSYCMRKVGLWGFQQIEGVACEGDSSLSMTSTPVSSHDGRGDRLTPTSTSPCRMVLRSQDATRSHVSEHTDSSPSPLVFRTRSRDSPSPSEDSPSPLARGKRPVTRSRGQGEAGLVGGEVPSSPQRRAKRSRLSSASSTDTTTSRSVFNPVAQHRDWCPWVSVAEVETGRDPESSDEPPSKPQSPDIPQPGWKAALDTFLAMKKSANPQETCTSQGLHDKSKRVFKIFRQWQVSSSQ
The following text describes a protein:
Function:
Key enzyme in methionine and folate homeostasis responsible for the reactivation of methionine synthase (MTR/MS) activity by catalyzing the reductive methylation of MTR-bound cob(II)alamin. Cobalamin (vitamin B12) forms a complex with MTR to serve as an intermediary in methyl transfer reactions that cycles between MTR-bound methylcob(III)alamin and MTR bound-cob(I)alamin forms, and occasional oxidative escape of the cob(I)alamin intermediate during the catalytic cycle leads to the inactive cob(II)alamin species. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (By similarity). Also necessary for the utilization of methyl groups from the folate cycle, thereby affecting transgenerational epigenetic inheritance (By similarity). Also acts as a molecular chaperone for methionine synthase by stabilizing apoMTR and incorporating methylcob(III)alamin into apoMTR to form the holoenzyme. Also serves as an aquacob(III)alamin reductase by reducing aquacob(III)alamin to cob(II)alamin; this reduction leads to stimulation of the conversion of apoMTR and aquacob(III)alamin to MTR holoenzyme (By similarity).
Miscellaneous:
MISCELLANEOUS: It is debated whether the reduction of free aquacob(II)alamin occurs spontaneously or is enzyme catalyzed.
Subcellular Localization:
Cytoplasm.
Sequence:
MRRFLLLYATQRGQAKAIAEEISEKAVTYGFSADLHCISESDKYDLKTETAPLVMVVSTTGNGDPPDTARKFVKAIKDKTLPPDFLAHLRYGLLGLGDSEYTYFCNGGKVIDKRLQELGAQRFYDTGHADDCVGLELVVEPWINGLWAALEKHFLSNRGREDTSETLTMASHASRDAVTPELLHVESQVGLLKLDDSGGKAAKVLEQNAVNSNQSSTLIVDFEASLTHSVPPLSQASLNIPSLPPEYLEVHLEEALGQEESHASVSLVDPVFHVPVSKAVQLTTNDAIKTTLLIELDISKTDFSYQPGDAFNVICPNSDSEVQFLLQRLQLADRREHHVAVTIKADTRKKGAALPQHVPERCSLQFLLTWCLEIRAVPKKAFLRALADHTGDSAERRRLQELCSRQGAADYTRFVREAGACLSDLLRAFPSCQPPLGLLLEHLPKLQPRPYSCASSSLFHPGKLHFIFNIVEFLSNTTEVILRRGVCTGWLATLVESILQPYMCANHVDGKKALAPKISISPRTTNSFHLPDDPSVPIIMVGPGAGVAPFIGFLQHREKLQEQHPGGHFGATWLFFGCRHKERDYLFRDELRHFLKCGVLTHLEVSFSRDVAVGEEEGPAKYVQDSLQRHSKQVAGVLLQDSGYVYVCGDAKNMAKDVHDALVEIISRETGVEKLEAMKTLATLKEEKRYLQDIW
The following text describes a protein:
Function:
Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis. It is thought that this protein is a protease that cleaves peptides bond in a small peptide (gene pqqA), providing the glutamate and tyrosine residues which are necessary for the synthesis of PQQ (By similarity).
Sequence:
MDHHAQHHPRSHACVLPNGLRLHLAHDPAASRAAAWLRVAAGSHDEPSAHPGLAHFLEHLSFLGGAAFPGDERLMPWLQVRGGQVNASTLGKTTDYFFEVTAEHLGAGLARLIDMLARPLLDIDAQRREREVLEAEYLARSADEQTLIDAALALGLPAGHPLRRFAAGRRDSLALESDAFQRALREFHAAHYHAGNCQLWLQGPQTLDELERLAQRACADLPGRAPGASPPPPPLLPFACEALALRLPGPPRLVLGFALDALRGADEQTLLAFAELLGDRSPGGLLAALGEQGLGESVALRVVHRDARQALLALTFELFDGSAAAALEAAFFDWLGALRDDAASLLAARRPLLAEPTAPLERLRQRVLGLPAEIRPACLDALRADRCLRLHLDSELDGAEARWSAGFRLSVAPVAAAPPLAAQRHAWRFELPLPPSAAAEGALFLRWRFPGVPARSRFLALRQALRPLCGQARLGGVEMGLEALGEDWSLSLLGPRDRLEAAVRPALARLLAAPPDWRANGERLSSAERRRSATGLPIRQLLDALPGLLGEPLAEVDDWRRTRWDALVMQAAMPDPRWMPGQAAGERLEPLPPRPGRHRRELAVDGESALLLFCPLPTQEVPMEAAWRLLARLHEPAFQRRLRDELQLGYALFCGFREVGARRGLLFAAQSPRACPARLLEHMETFLQRSAEALAQLPARRLAGLRKALADDLRRAPGSFAERARRAWAEHLGGGAGRSRLLAEAALGLSGDDLLAAQARLLEARGGWWVLSSRR
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase (RNAP) to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma-E controls the envelope stress response, responding to periplasmic protein stress, increased levels of periplasmic lipopolysaccharide (LPS) as well as acid stress, heat shock and oxidative stress; it controls protein processing in the extracytoplasmic compartment (By similarity).
Subcellular Localization:
Cytoplasm. Note=Associates with the inner membrane via RseA.
Domain:
The sigma-70 factor domain-2 mediates sequence-specific interaction with the -10 element in promoter DNA, and plays an important role in melting the double-stranded DNA and the formation of the transcription bubble. The sigma-70 factor domain-2 mediates interaction with the RNA polymerase subunits RpoB and RpoC (By similarity); The sigma-70 factor domain-4 contains a helix-turn-helix (H-T-H) motif that mediates interaction with the -35 element in promoter DNA. The domain also mediates interaction with the RNA polymerase subunit RpoA. Interactions between sigma-70 factor domain-4 and anti-sigma factors prevents interaction of sigma factors with the RNA polymerase catalytic core (By similarity).
Sequence:
MSEQLTDQVLVERVQKGDQKAFNLLVVRYQHKVASLVSRYVPSGDVPDVVQESFIKAYRALDSFRGDSAFYTWLYRIAVNTAKNYLVAQGRRPPSSDVDAIEAENFESGGALKEISNPENLMLSEELRQIVFRTIESLPEDLRMAITLRELDGLSYEEIAAIMDCPVGTVRSRIFRAREAIDNKVQPLIRR
The following text describes a protein:
Function:
May act as a tumor suppressor.
Subcellular Localization:
Secreted.
Sequence:
MLWFVVGALFPALLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCESKSIQNRACLGQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLDCPGNDEIPRVDKLVEKILHCSCQACGKEPSHEGALFNVYLNAEENMPAEGPGPHHYAHHQQEVEEPPASSHHHHEEEGDE