lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress. Catalyzes the head-to-head condensation of two molecules of farnesyl diphosphate (FPP) into the colorless C(30) carotenoid 4,4'-diapophytoene (dehydrosqualene).
Miscellaneous:
MISCELLANEOUS: CrtM is not functional in a C(40) pathway, however independent mutations on Phe-26, Trp-38 or Glu-180 are sufficient to permit the synthesis of C(40) carotenoids, such as lycopene and 3,4,3',4'-tetrahydrolycopene, although there is a decrease in the synthesis of C(30) compounds. The combination of mutations at Phe-26 and Trp-38 appears to be harmful for the general performance of the enzyme; MISCELLANEOUS: Upon coexpression with Erwinia geranylgeranyldiphosphate (GGDP) synthase, CrtM produces novel carotenoids with the asymmetrical C(35) backbone, such as 4-apophytoene, and the production of the natural product 4,4'-diapophytoene drops dramatically.
Sequence:
MTMMDMNFKYCHKIMKKHSKSFSYAFDLLPEDQRKAVWAIYAVCRKIDDSIDVYGDIQFLNQIKEDIQSIEKYPYEHHHFQSDRRIMMALQHVAQHKNIAFQSFYNLIDTVYKDQHFTMFETDAELFGYCYGVAGTVGEVLTPILSDHETHQTYDVARRLGESLQLINILRDVGEDFDNERIYFSKQRLKQYEVDIAEVYQNGVNNHYIDLWEYYAAIAEKDFQDVMDQIKVFSIEAQPIIELAARIYIEILDEVRQANYTLHERVFVDKRKKAKLFHEINSKYHRI
The following text describes a protein:
Function:
Responsible for microtubule translocation. May be important for the organization of phragmoplast-specific arrays of microtubules. Plays an essential role in stabilizing the mitotic spindle. Required during mitotic cytokinesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle.
Sequence:
MAHTPNPSRRSWVGPPTPFLTPRPERRELRWAEAGSHSSVRRSGVGACSINGSNDRDREANVQVVLRCSDNGNFEQIAAGARSQMHISMVSLMRFYDWCMVRPLSVEEQKANVQSAVSCNDTKREVTVLNSLFKQADKTFTFDTVFGPKSQQRAIYDHAVAPIVDDVLEGYNCTVFAFGQTGTGKTYTMEGEMMQQVGELPTSAGVMPRAVRHIFDILEAQKADYSMKVTFLELYNEEITDLLASEDQSRFLEDRHKRPTLSLMEDGKGGSVIRGLEEIVVYSPGEIYSLLQHGSTRRRTADTALNMQSSRSHSVFSIYIHVKVTTTGNRELIKCGRLNLVDLAGSESIARSGAKEVRAREAGELNKSLLTLGRVITALVEDSVHVPYRANMSLKEKDFIISNLLHAENVILERAKVLCGTVETASGDIADLQNKLGRQSKTEVENKGLLFNFRSQLDQSLGLLRNTVVRSICEQRQFLESMTGQMNSYFSAKSESANHLKRRIAKAKDMHTSGVQCMNELVNTLRQRSITDSEQMKLNISSQAIAVDNFLAVMVSEAEQVLTEVLRSTSELKELLAFSAEQQELGLQKSLTSAQAMSKTSIDFFNDISTHASRLMKLMKQSQRGCSSRLAEFEKGFEEAAIREEQAALDKIAGILAGLTARKTTMVSEYVGQLNERYSEEQEHLALEMSSLQQVSDNGKKEAASCAEKLKNQILEDMSSHANTKDKMGDVLQQCLKGSHHSVSYWSHTQSCLEHLNKSSVLEANDFIQERRNENESIIQEIQLRSSHNDAGFHAITSDILTTSENSHLVDHETRERMETLSTSFSNHLGLLTEKHNQGTESIRTFASNCIEKDYSVNSPVRHRPRELLAGAYSFESIEELRASMPDLVAKFKSKDKLDEVDKGKSSSDQTTRAPRSPLTPVNH
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Miscellaneous:
MISCELLANEOUS: Present with 4030 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MNWLFLVSLVFFCGVSTHPALAMSSNRLLKLANKSPKKIIPLKDSSFENILAPPHENAYIVALFTATAPEIGCSLCLELESEYDTIVASWFDDHPDAKSSNSDTSIFFTKVNLEDPSKTIPKAFQFFQLNNVPRLFIFKPNSPSILDHSVISISTDTGSERMKQIIQAIKQFSQVNDFSLHLPMDWTPIITSTIITFITVLLFKKQSKLMFSIISSRIIWATLSTFFIICMISAYMFNQIRNTQLAGVGPKGEVMYFLPNEFQHQFAIETQVMVLIYGTLAALVVVLVKGIQFLRSHLYPETKKAYFIDAILASFCALFIYVFFAALTTVFTIKSPAYPFPLLRLSAPFK
The following text describes a protein:
Function:
Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription. Together with URI1, associates with chromatin to the NKX3-1 promoter region. Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm. May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM.
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Predominantly localizes to the nucleus. Localizes to spindle pole during mitosis.
Sequence:
MATPPKRRALDTVGEKVLRYEAFISDVLQRDLQKVLDHRDKVYEQLSVYLQLRNVIERLQETNHSELYMQVDLGCNFFVDTMVPDTSRIYVALGYGFFLELTLAEALKFIDRKSSLLTELSDSLTKDSMNIKANIHMMLEGLRELQGLQNFPEPSPH
The following text describes a protein:
Function:
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
Subcellular Localization:
Chromosome. Nucleus, nucleolus.
Sequence:
MDTKTHSLPITHTQLHSNSQPQSCTCTRHCQTFSQSCRQSHCGSRSRSSSQRPASHRNPTGAHSSSGHQSQSPNTSPPPKRHKKTMNSHHSPMRPTILHCSCPKNRKNLEGKLKTKKMAKRIQQVYKTKTRSSGRKSN
The following text describes a protein:
Function:
Essential cofactor of the RNA polymerase L that plays a central role in the transcription and replication by forming the polymerase complex with RNA polymerase L and recruiting L to the genomic N-RNA template for RNA synthesis (By similarity). Also plays a central role in the encapsidation of nascent RNA chains by forming the encapsidation complex with the nucleocapsid protein N (N-P complex). Acts as a chaperone for newly synthesized free N protein, so-called N0, allowing encapsidation of nascent RNA chains during replication (By similarity). The nucleoprotein protein N prevents excessive phosphorylation of P, which leads to down-regulation of viral transcription/ replication. Participates, together with N, in the formation of viral factories (viroplasms), which are large inclusions in the host cytoplasm where replication takes place (By similarity).
Subcellular Localization:
Virion.
Domain:
The N-terminus consists of a long intrinsically disordered tail. The central part contains the coiled-coil multimerization domain (MD or OD) (By similarity). Forms a four-stranded coiled coil structure (By similarity). The C-terminus constitutes the alpha-helical X domain (XD) that binds to the nucleocapsid (N-RNA complex) and the L polymerase (By similarity).
Sequence:
MDQFIKQDETGDLIETGMNVANHFLSAPIQGTNLLSKATIIPGVAPVLIGNPEQKNIQYPTASHQGSKSKGRSSGAKPIIVSSSEVGTGGTQIPEPLFAQTGQGGTVTTVYQDPTIQPTGSYRSVELAKIGKERMINRFVEKPRTSTPVTEFKRGGPGAAAQGQTIQEEGIDGNGASAGSKERSGSLSGATPYAHLSLPQQDSTPANVGIAQQSAISANEIMDLLRGMDARLQHLEQKVDKVLAQGSMVTQIKNELSTVKTTLATIEGMMATVKIMDPGNPTGVPVDELRRSFSDHVTIVSGPGDVSFSSSEEPTLYLDELARPIPKPRPAKQPKPQPVKDLAGRKVMITKMITDCVANPQMKQAFEQRLAKASTEDALNDIKRDIIRSAI
The following text describes a protein:
Function:
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
Sequence:
MSSSLYALIRESPPGEVNEVVKDLQALGLDNQVEIERNILAYHEQNNSIVTLKLEDGMTHACVLSSHCKLPDNRYYDQVQQKSFSVSVDDMTASDIEAYSEKPEIDEKILTQLKAVVQKHYLSGPAYSVFVDETAPKVLHIVLVASKYNPNNFWNGSWRLNATYSIEEKTLKGSVYARVHYYEDGNVWLDSTKDFSSTVENDSGLEQALEKVENEAQKSINSQLAGLNNGMFKTLRRQLPVTRQRINWENVNSMRMANA
The following text describes a protein:
Function:
Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
Subcellular Localization:
Cytoplasm. Endosome. Nucleus.
Sequence:
MSDVRLSSGSPTVERVEARQQDSVRQVRRTLFGTPDPEETRRFLAEITQEGAQDFAQRYNFDPLTERPLPPGNYEWQKDDDAPEFYRRPPHGCRRPRWDDGGSSQEDEGRTGTRSPAPSLRRSGSRKRRADTSDSCSKPCPNKRSRPDGDDPEDQSDGARSLALSVGPSEADSAEDVH
The following text describes a protein:
Function:
Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity).
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Domain:
The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.
Sequence:
MSLPYAADAETSLSPSELQVLKSQYETELASGHVTTQTKFNYAWGLVKSKQRAEMSIGVGLLTEIYRSDPPRRRECLYYLSLGHYKMGNYDEARRFNALLIEREPNNLQAQSLNQLIEKGVAREGYIGMALIGGAAAVASIAIAGLMRRGRR
The following text describes a protein:
Function:
Mediates the import of RPA complex into the nucleus, via its interaction with importin beta.
Subcellular Localization:
Nucleus.
Sequence:
MEAERRHRALYKGTTPPWKETYRKRCVERLKRNRSKLLDKFRQVGERIHGGVGGSFLVQEVMEEEWKAMQSENGSFPSMWKKEAFSQALNIMRDPDELATLEEIKQELLLEEKAMIEEFENILQFEEQCLDSVVELSTGDQIVCPVCNRNYLTVTSCFIVCQCGVYINTQSQGMSIEKLHSLLESSLTSHGYHCTKLPVFSVATELGGAASLFMSCQECDAMVVIL
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MQSYSHLYEPMSHPSGSSSPHPTSPGGFNVPYTGSPSASHLGATASASSNMAQNPLSFGTFYFQQPTSSQSNHGPLASHPPQHLDSYSSTSHTPHQHFSPSADHHSSSSASVAALSNSGRLSWANSPADSYHGVTSNATTHSSGADSHASLVNNKYPWDINPASMRSDTGHIGSPYSASDLLHPATASALGFDDDSGSGGNVRPRARKRTRAEEEPRSRLSSSSRSRTRPRIPSALSNANSPASDFHHSISSYHADPEDTDITAWINAGDAEDLGTSHVADTEHSRLWSSFGPGFPTEASHASPYHGSATAPALPASLSNSRAQSVVGSEDFAYHASPAIHSGSTNLGLSVSLHDHDAVDVKPGSAQLVQDDSAPAEDEPLYVNAKQYQRILKRRATRARIEEQRKKDFLAYMQTRDKARKEGNGLDEDGKKPYLHESRHRHAVRRPRGPGGRFLTKAEMAQSAASAS
The following text describes a protein:
Function:
GTPase-activating protein for the ADP ribosylation factor family.
Subcellular Localization:
Cytoplasm.
Sequence:
MGAVPSKPDDPLGTSCYMDPAFVVDRISVMSTSSSSAKAIAANNNVSQASVRNSGVLAISQKPNEQVDVLTHLVTPLCQLLLSSADHTRNVLTTANDFVQDPDDPSRFLVRVRLPPDATCLAQFGIQLSDSISGGALITASSPKELHHFITNEFFHDPNIHTRSNVAFLGDFTPGKMEFVWELSHHLGKGPLYCCFVEYDKRQDSLRTLAQFKFFADTQTTTPQVTSKLSNLALSPSSATQGSSPSTNLTPPSSDITYNSTASASPGSPTSPLRSPKTNVFDASSPLKLAEPMSLTQALSQQDAIKGLGQSVDSLLEKSISPADVPIQNGDDGPVFRATIQSLEKKTRSLKALIKRLYKQAVVVSERQSELATEYTLYLDYMKDIDGIQVAAGATCEQWVQIAAWLNSSNVDLQMLVLTPLKKFYENEIKMFEGHKKDFDDESREYYSWLSRYLGQKSPPKASKSDSKYQDKRKAFELKRFDYFTYLTDLHGGRKMQALTLSISQNEEKQLARFLALSAGIQASKPKIDRLVDHVKQASKDWTRSRTDVEIRRRQLERSIEAGESTLPSAQNTQAPSLSAALSNSNNSGSTNNLGAGAPTAPNLSSTPIPIPTPMSGPGAPTRSRSQGANRAIPRLNTSLGGMQGARSAVPSLPALPNLTPSASASNGSSTAQNIKSLIIDSPPKPSKRHSYIEDVSDHLNLQQQQQQQQQQQQHSFEELSPDSAEHKEGLLWSMDPSTKNINKKTVGWHKYWVVLAGGRLSEYSNWKQGLEANRTPIDLKMALCREARNSDRRFCFEIVTPQTKRVYQATSEDDLATWVAAINGAISTSLENVSSPPRESSAQMAQRELSRSPLKDNGAHLRRVVSSSAGTAIPGSGAPPSMSQAPPQMGPMSPDVYKLAVSIDPSNSTCADCASTQGVTWISLNLMVIICTQCSAVHRSLGSHVTKVRSLTLDTRDFTPAVIDAIRQVCNRTLNDIYEAKLSDKSTLVKNREHFIQNKYVSRKYAAPLNGNQALIDAIVAHNVLELLRAVFAGADINLPVNDGLLIYSLRANPVHFAIPELLLLNGTKVPSIELSGKVSLSEEAKRYLLQKVERANE
The following text describes a protein:
Function:
Converts galactitol 1-phosphate to D-tagatose 6-phosphate.
Sequence:
MKSVVNDTDGIVRVAESVIPEIKHQDEVRVKIASSGLCGSDLPRIFKNGAHYYPITLGHEFSGYIDAVGSGVDDLHPGDAVACVPLLPCFTCPECLKGFYSQCAKYDFIGSRRDGGFAEYIVVKRKNVFALPTDMPIEDGAFIEPITVGLHAFHLAQGCENKNVIIIGAGTIGLLAIQCAVALGAKSVTAIDISSEKLALAKSFGAMQTFNSSEMSAPQMQSVLRELRFNQLILETAGVPQTVELAVEIAGPHAQLALVGTLHQDLHLTSATFGKILRKELTVIGSWMNYSSPWPGQEWETASRLLTERKLSLEPLIAHRGSFESFAQAVRDIARNAMPGKVLLIP
The following text describes a protein:
Function:
Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.
Subcellular Localization:
Cytoplasmic vesicle, autophagosome. Cytoplasm, cytosol. Mitochondrion.
Domain:
The N-terminal region is essential for activation of the IFNB promoter activity.
Sequence:
MAESPGLHPSLEGIFHILAQVPEEKLIDYKHKLSCERQNRRSSQLLQTMILLTLKRETEARRSLDALRGDPVAARISRYCTATANTANVVPPLQKEEGAAEMWLAVARIYSLLVDAKWCCHVLRDEAYRVAVAAFRSGGGSKDRLRGLADEALEKCGMGFMFGSGETGKALRVSDPVPVTRVSNTVPVPRASDPVPVTRANDLVPVPRASDPVLVMRANDLVPVPRVSDTVPVPRANDQVPVTRVNNLVPVPRASDPVPVMRANDLVPVPRVSDTVPVPRANDQVPVTRVNNLVPVPRASDPVPFLRVNDPVLFPKASDPVPVLNSLDPQPLRSTGSPTSIVSHLEISHSLTVPFQTHSVHYGTGISKLCGEIRDTEERNRDESLTGRTESGDLKGSRCSSSDPSVSPERSVQCPEPVTGKHVSPRSLPHDPRISSADSTQYPRNSVADPYSQKPPSNSVSGPPPAVSSSSEPQEFFTFVVVHADEDEAIACRVKARLESMGIPDGATYSEDFLVPGRCQLGCFENALEDSAFTLFLLTENFKSRLCAYQTNTALMDSLTHFCKANTVIPFLPKERPLKTREMPLLLKGLVPLDENSPVFAKRVKKTFREEDIRRKKADWSVRRQNRERERLQEQNREYQQQLQRLSELSMNMTSLQGFPGMPQPPPGPDLTSLCPSFMFPQGFGGARPPLIIQNAQMVQIGDCNNMQVERTNATLGTAEENGIVNP
The following text describes a protein:
Function:
Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
Subcellular Localization:
Mitochondrion.
Sequence:
MIARQSYRKLFRNISITRAFSNSHLRISETKKEPQANSSSSPPPHTDDLYFGKFTKEEYEDAKKIIQEQISKLEGQIKGDYNVRENLGKFSQFPEPASQDSKPVKVENLSDFFRQTIKLTGPIPLSTYMRQCLTHPEFGYYTTRDPLNLRTGDFITSPEISSVFGEMIGIWYFSIWQQQKYPESIRFIEFGPGKGTLIHDIMKTFNKFVEKLLPSDQKRPKIEIALIEASHVLRKEQWKLLCNPEDPMETTGEGYNRSATKWNNDIIWFDTEKDIQQGDKNVANFIVAHEFFDALPIKSFIREEKGWRELVVEHTPSVNNTQPKLEESTSARGANKFETDDSLDTEFHLTIAPKETPSSMIPQISKRYRDLPVGTRIEICPDAELYIMKMAKLLSDSNDKGAILVIDYGTENEIPENSLRGIYQHKFVSPFWNPGEVDLSIDVDFQALKQLTEGIVDIYGPLKQGDWLHNIGIGYRIDQVLKKNEQDPEVQDKIYGAYRRLTDGEQMGSIYKFMALLPKGSNNPPGF
The following text describes a protein:
Function:
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MSDAIKLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIIYAMSELGLSAQSKHKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEARLSKFSEVLLSELGQGTVEWGANFDGTLKEPKVLPARLPHILLNGITGIAVGMATDIPPHNVRELVNACVALLDEPKLDLEQLMAYVPGPDYPTEAEIITPAADIAKIYETGRGSLKARAVYSVEAGEIVITALPHQASSGKILELIAAQMQAKKLPMVADLRDESDHENPVRLVIVPRSNRVDCDQLMAHLFATTDLEKSFRVNLNVLGLDGRPRVKGLKDLLTEWLEFRVDTVRRRLEYRLDKVLARLHILEALMIAFLNIDEVIEIIRFHDEPKAELMARFNLTDKQAEAILELKLRHLAKLEEFKIKAEQDELEAEREKLEQLLGSERRLKTLIKKELIQDGETYGDDRRSPIVERHESKALTEQELTPSEPVTVVLSDKGWVRSAKGHDIDAESLSYKAGDQYLCSAMGRSNQAAVFIDSSGRAFATDSHSLPSARSQGEPITTRFNMAPGETMQHVILGEDEQCFLLATDAGYGFICTFNDMVSRNKAGKALLSLPTNAKSLPPKPIDRNREMSILAITNEGRMLLFSLEALPQLSKGKGNKIIGIPSERAKNREELMTHLQLVPADTSVTLWAGKRKLTLKPSDLEHYRGERGRRGAKLPRGLQRVDSMELGEGAEPIPSI
The following text describes a protein:
Function:
May be involved in lipid metabolism.
Miscellaneous:
MISCELLANEOUS: Present with 13900 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MPLNIIGTALLDGTDKIPYYQTIKKVAPYVLATGAIKYWSRGPSNTWERKLHGKVYLVTGATSQGMGTSVAYKMAELGAQLIILTREVDEWVTEWCEELREKTKNELIFVEKCDLSNLWEIRKFATSWLDNSPPRRLDGVIVMSGDMEPWGIPKISLPQRRSSKDGLELQIATNYVAIFHLLNLLQPSFKAQPPDRDVRIILATCWLQVVGDINIEDPLWQNAKYKSALKFFASSKLQLGLSMMELQRRLTEDIKNQKTNGAERTGKNVTITMVQPGTMRSNSLRRVISNGSVVLLIILYCILLYPILWLFTKSGRRGDQSFLYALMTPELEEVNLKDTKVKYISDCSIVKFARKEFDDEELQKKLFDNTERDILQLEKKVAAKRNANKTGNQNSKKKSQNKSRKDD
The following text describes a protein:
Function:
Part of the ABC transporter complex YkoCDEF that could transport hydroxymethylpyrimidine (HMP) and/or thiamine. Could also transport other HMP-containing products. Probably responsible for the translocation of the substrate across the membrane (Probable).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGVLLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSVGISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDEVQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRNRTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS
The following text describes a protein:
Function:
Acts as a transcriptional activator during early development, limiting the extent of mesoderm formation in the gastrula. Binds to DNA via the target sequence 5'-GT[AC]AACA-3', with 5'-GTAAACA-3' being the preferred binding site (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MLGAVKMEGHEATDWSSYYGEPEAYSSVGNMNAGLSMNPMNTYMSMSAMSTSANMTAGSMNMSYVNTGMSPSLTGMSPGTGAMTGMGTGVASMASHLSPSMSPMSAQATSMNALAPYTNMNSMSPIYGQSNINRSRDPKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKCEKKPSLREGGGKKLSEGSSSVGSAANSSSESSVGNESPHSSSSPCQEQKRSLVDMKSSQGLSPDHAASPASQAQHLLSQHHSVLSHEAQSHLKPEHHYSFNHPFSINNLMSSEQQHHHHHHHNHHHHHKMDLKAYEQVMHYSGYGSPMTGSLAMSTVTNKSGLESSPISSDTSYYQGVYSRPIMNSS
The following text describes a protein:
Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSKIYLKAMEDVVQRNTDNTNRITEQAQGFVVSENAGDSLLHTSFDLTTAQSIVKHLHASFLKLAQSCVRDLDTDDKLCFLRVKTRKHEFLVSPEEAFTVTVVL
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
Miscellaneous:
MISCELLANEOUS: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDWLYSLIYGIVEGITEFLPISSTGHLILTGNLLHVPWPKEVKDTFEVVIQGGAILAVLVYYWRDFLKIRHIGHDRGQQRLWLGVVLACIPAVILGVLFGDTIKAYLFRPSVVAWALIVGGVLMWLLESRKATPDTHDIENISAGKALAIGAAQCLALLWPGFSRSASSILGGMLLGLDRPTATKFSFYLGVPTLGGAALLDFIKSREILAQIGVVNVAIGAVTSFVVAYFAIGWLLRFVSTNNFKGFAVYRVVVGVLILVLIARGVLQNGSLA
The following text describes a protein:
Function:
Involved in sporulation and has a role in meiosis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MERLATRSSHDDPYSRSSLPTSNAINSNHESNGSTFSYVQSLRRAKATVWSDIGRVAPLHSSPSIKSSSQNGKSSSKGLGGMRSRVFSSQHHGVYHTRPASLHSRTMAPQHTILTPRLSATEGKDDDEDELVISTSNTAPTYISMIESSRASSTHSGTAPSIMGMSIHSRADSRAETTQSDGFESRSGSPTHDIQSYLVNRRSSSSESSDEDSAEEGMKRLVITNMGDNDEFDSD
The following text describes a protein:
Function:
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Subcellular Localization:
Cytoplasm.
Sequence:
MSIRVELCGGLDLLFNKQKELTVQLTDIGQNATVGDLIQYMTNKIEDESKCELFVMDGSVRPGIIILVNDQDWELLDKEDYVLETKDNVVFVSTLHDHLGNISVQHSHRSVHLQ
The following text describes a protein:
Function:
Could be involved in magnesium uptake.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTAEFIIRLILAAIACGAIGMERQMRGKGAGLRTHVLIGMGSALFMIVSKYGFADVLSLDHVGLDPSRIAAQVVTGVGFIGAGNILVRNQNIVGLTTAADIWVTAAIGMVIGSGMYELGIYGSVMTLLVLEVFHQLTFRLMNKNYHLQLTLVNGNTVSMLDWFKQQKIKTDLVSLQENEDHEVVAIDIQLHATTSIEDLLRLLKGMAGVKGVSIS
The following text describes a protein:
Function:
Required for vacuolar fusion. Involved in the early steps of the fusion pathway.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein.
Sequence:
MLFEVFGEVLASYIVSSKTKGELAFPVNNAPPDSLVAINCVVLFLRSAIGSCSGAKELIRSSALELSCSSSCGLPATDKPGSFHSGALSKSILSANEAVVSKSSLSFLSSFVDI
The following text describes a protein:
Function:
Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+). Can use either oxygen or fumarate as electron acceptors, which allows the enzyme to be functional under aerobic and anaerobic conditions.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYAQGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRNERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDGRCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELTDLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVSRVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGGVSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNRQYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKDITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKIRKNEGIWNNESFTAEKITESLFS
The following text describes a protein:
Function:
Antiporter that mediates the import of reduced folates, driven by the export of organic anions. Also acts as an importer of immunoreactive cyclic dinucleotides, but with a lower transporter activity (By similarity). Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates (By similarity). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (By similarity). Also mediates the import of antifolate drug methotrexate. 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
Sequence:
MVPTGQVAEKQACEEPRQDRELKSWRWLVFYLCFFGFMAQLRPGESFITPYLLERNFTKEQVTNEIIPMLPYSHLAVLVPIFLLTDYLRYKPVLVLQCLSFVCVWLLLLLGTSVVHMQLMEVFYSITMAARIAYSSYIFSLVQPSRYQRMASYSRAAVLLGVFISSVLGQVLVTLGGISTYMLNCISLGFILFSLSLSLFLKRPKRSLFFNRSALVQGALPCELDQMHPGPGRPEPRKLERMLGTCRDSFLVRMLSELVKNVRQPQLRLWCLWWVFNSAGYYLITYYVHVLWKITDSRLNYNGAVDAASTLLSAITAFTAGFVNIRWALWSKLVIASVIAIQAGLVFCMFQIPDIWVCYVTFVLFRGAYQFLVPIATFQIASSLSKELCALVFGINTFLATALKTSITLVVSDKRGLGLQVHQQFRIYFMYFLTLSIICLAWAGLDGLRYYRRGRHQPLAQAQALSPLEDSVQAISLQDGDLRRPQPSAPQLLPEDGSVEDGRADLRVEAKA