lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEDGGPPESLAAQTTCEPSESLSSAHRHLSRRNGLSKLCQSRTALSEDRWSAYCLSSLAAQNICTSKLHCLVAPEQTEAAGSLGSMSCCSLLRGLSSGWSTPLLPALVCNPNKAVFTVDAKTTEILVANDKACQLLGHSSHALIGQRLTRFFLKPDSDVAKALSEEHVEADGRAAVVFGTVVDVVSRGGEKIPVSVWMKKVKQERGPCCVVVLEPVERVSAWVTFQSDGTITSCDSPFALLHGFVSSEEVLGQRVTDLIPSVQLPPPGEPVPQNLKIQRSVGRAKDGTTFPLSLKLKSECGGEAVGGSRAVPECSYSASVWVFSTISGLITLLPDGTIYGINHSFALMLFGYGRTELLGKNITFLIPGFYHYMDLVCDGSLPLPDLAERLDIGTQSGPGETSAGPWQGQNLAGTASGPRAGGTLAGDRAQPQGEAPERGGALEAVVGTQAAADPGDRLPPSLPRLPTPTLGVENIPKGSSSAHRQQSSPKDQQDIPGGSPPAHRPQSSPEDQRDIPDGSPPAQRQQSSPKDQQDIPDGSPPAQRQQSSPGDQRDIPGGSPPAQRQQSSPRDQQDIPGGSPPAQGWSSPEDQRDIPGRSPPAHNQQSSPKDRWNTLLGQEEPAAPESLRQDLVGRSRCDPVVTWTFASQGGPETPALAEGRSRNAELCGLYQEAQLEWTGLSSASSSNRRADSVMPEPRAAGQLAAEGLPMPYPGYGGEQSTQPGSPPGTARLLFSTPTLDEPWVAVENDREEIQTCLLREQLPRLSFVGPLGVSYSELASAEHPPLPPPVSLCDPGGRDFCSRVGSSSAYYALATDLPGVLDAVQAQEADGNSFSWNLKELRFSEWADGTSSTCSCAASELVGTPSPSPAGSDVDVSGLHGRRPDVLDDRELLLLTGTCLHLGEARQFHESRLGPDRVELSETCLESSERGGGRSRESSPCVLPAPEAGPVDVCPSEEPRLSFQVTSTPVRDDSLVAPGDMCTQHGIQEGTYAGSCYHRDGAQLSVQFEVKRVELQGAATLFCCWLVKDLLHGPRDSATRARLLLASLPGSSHSVCEASGSSVGEGLRSKPWFDDAPRAVELEGQAACEGAYSHKYLTLSPLGSGAFGFVWTAVDKEANKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDVFENQGFFQLVMEKHGSGLDLFAFIDRHPSLDEPLASYIFRQLVAAVGYLRSKSIIHRDIKDENIVIAEDFTIKLIDFGSAAYLEKGRLFHTFCGTIEYCAPEVLMGNPYKGPELEMWSLGVTLYTLIFEENPFCELEETMEAVIHPPYLVSEALMHLISGLLQPVPEQRTTLEKLVTDPWVIQPVNLADYTWDEVCRVNKPESGALSTVSLELEGRCAGELAWAAGPGGPLCPRGGP
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MTSSFALPGPPAGDARVRGEWLAAASAFGGYLELEGRVHGGQPSGAVFTDSAMPLLLSSKGAPSSLLGDIEAYLNPISGELLADPALRLTRYLAAAKLSLVLQRQQALGTGSGTASGDTHEHEKRPKKLLDQAMSSLAMEFCHLRIWRLDADVLRGHPHRRLGISPASIWESVVRGGCRGGSRSAADSVASWPSSSSTSFGGTSGTGSSSGFLSALCEDMSVRSDKAFGRMDLIDRKVLSTINDIAGLMIQGGYEYEDMLRRAIDRHSAQLASYLEILDMDNILGGHKEEPKETVLNVWTAGMHIIVGVLGEMRRQLNGQDLGWFNMLKEDYFSAIAKQSVRRLLRAADSICTQIHGVGVASPVVDPVHMMDTDDTYTAVKPDDLLLSSRTAVGLVMMYKALNCGMPIVLALLSTGHAKDSILAEGEALVQRLSDMFVKLCVEQKELVRARRLDISDTGVHPFTRRVMAHVRTLVQHGSTVCLMLKGRPKAAFHELVAQLVSSLECALDSNSRGLQIPGQQQMFLLNNAHMMLQEARAERDLGRVLGEGWLARRHDQLDVFIAGYVDTSWAPVVSCALRRRRRTTRARETLWPASSHRQSFDKLTWLLETTCRVHRTWKVSDPLVRDKVREAVFHKVVPVYRMHMENCQSEKKQQQQQKCARRHSVATAGTVRGVG
The following text describes a protein:
Function:
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
LAVQSWASYLTLFASVSSSVKWNGKPPYSTFAKKFPNGAIDTSTEKTLIEEKVKLEEQVKETLEKYKRALADTENLRQQSQKLVEEAKLYGIQGFCKDLLEVADILEKAIESVPKDEIKEENPHLKNLYEGLVMTEIQIQKVFKKHGLLKLNPLGDKFDPYEHEALFHTPIEGKEPGTAALVNKVGYKLHGQTLRPALVGVVKEP
The following text describes a protein:
Function:
Suppresses temperature-sensitive mutations in BamB when overexpressed.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell outer membrane; Lipid-anchor.
Sequence:
MKKRVYLIAAVVSGALAVSGCTTNPYTGEREAGKSAIGAGLGSLVGAGIGALSSSKKDRGKGALIGAAAGAALGGGVGYYMDVQEAKLRDKMRGTGVSVTRSGDNIILNMPNNVTFDSSSATLKPAGANTLTGVAMVLKEYPKTAVNVIGYTDSTGGHDLNMRLSQQRADSVASALITQGVDASRIRTQGLGPANPIASNSTAEGKAQNRRVEITLSPL
The following text describes a protein:
Function:
Component of the oleanane-type triterpene saponins (e.g. saponarioside A and saponarioside B) biosynthetic pathway, leading to the production of natural products with detergent properties used as traditional sources of soap. A dehydrogenase/reductase that, together with UGT74CD1, mediates the conversion of QA-tri to QA-triF; UGT74CD1 may transfer 4-keto-6-deoxy-glucose to QA-tri, which is in turn reduced to D-fucose by SDR1, thus leading to QA-triF formation via the initiation of the C-28 sugar chain.
Sequence:
MAEASSFLAQKRYAVVTGANKGLGLEICGQLASQGVTVLLTSRDEKRGLEAIEELKKSGINSENLEYHQLDVTKPASFASLADFIKAKFGKLDILVNNAGISGVIVDYAALMEAIRRRGAEINYDGVMKQTYELAEECLQTNYYGVKRTINALLPLLQFSDSPRIVNVSSDVGLLKKIPGERIREALGDVEKLTEESVDGILDEFLRDFKEGKIAEKGWPTFKSAYSISKAALNSYTRVLARKYPSIIINCVCPGVVKTDINLKMGHLTVEEGAASPVRLALMPLGSPSGLFYTRNEVTPFE
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MARSKIPEGLGEPIPYDPDFNGPLRHRSCTDIICLLIFFVFIGCWAGVAIYAFSSGDPNTLLVPKDSYGSRCGLDEHVKDRPYLFFFDLSKCFSPSVPFTGCQTKQVCVEKCPDYYYYFDQDPGNYKGHLICDYNIDPSQESPEKLVKEGKCARYYFKSSSFLNRCLYNTADRNKPNKDTNVEKEISELKKHLSKIAMWMSLFVQNTIGYFTDNQNYQQKPTHLLLIAVEKRCIPTIDDSFYETLEKFALNDTQKFLASIKNIKALSQAEQVGQNIVDDLVESWWKILAGVGIAVLVSIIYIMMLRWLAAPMVWLSLIGVLALLIAGVYFTTVKYIELKNKTDEDVETNNIFESYATKKDTWLVLLIICSIVLAIVLLMMIFLRKRIVLAIALVKEGSKAVSSVTSVLFFPVFPWILQIAVIAFAICVALYLATTGDPEYKIRGMTSDCPCFADFKNGTKCDPTTFRNLTCLTSTLCSDVTCKFTTMNNPKWYPYLQAFNIFGFFWGTFFVSALGQMILASVFATWYWTFNKSNLPFFAVLEATGRTLRYHIGTLAFGSLIIAICRMIRVALEYIDHKLKKYDNEITKAILCCCKCFFWCLEKFLKFLNRNAYIMCAIHGKNFCMSAKDAFMLLMRNILRVFVLDKVTDFLFFMGKLLITMGVGAISYVLFATDLTGIDNSGLHYEIVPVIVIMIITYIVATVFFNVYSMAVDTLFLCFLEDCERNDGSSEKPYYMSRNLMKILGKKNKQD
The following text describes a protein:
Function:
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MLWPDFIEETKTYLINGLKKYFLVALSAFALILSFPPFDLYFLAWFCLLPFFFFLYKTTDYKTIFKGGLIFGFLYFLGNVYWIYHSLYYYGSVPLILSYFIVALLALYLALYPAFFALIYKNLFKNMLPTSFYAPFIWVSLEVLRNYLFTGFPWAIIGYTQYKFLIIAQLADITGIYGISYLVILFNCFIFDLLIFKKNKIRYPLLSYIPTVISIILVFLVFLLTIGYGIKRFYEPINGKIFRVAVIQGSIPQNEKWDFNKINEILNIYKNLTHQAKTYNPQLVVWPETAVPFIFEKNKYFSSELVNFVKEQNIYLLFGSIMERQQDKYTNSAVLIDPNGIMAYYYDKIHLVPFGEYVPLRKILFFIDKLTVGIGDYQAGNGYNIATTPFGNFATLICYESIFPGQVRKFYQKGGSFIVNITNDGWFGTTSGPYQHFSMAVFRAIENRKPLIRAANSGISGFIDSKGRIISKTKLFERVYLVEDIHGNDKVSFYTKYGDIFAYVCIIFSLIFIIGNIKFGGKKWLHLRI
The following text describes a protein:
Function:
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
Miscellaneous:
MISCELLANEOUS: The reaction takes place in three steps, mediated by a phosphocarrier histidine residue located on the surface of the central domain. The two first partial reactions are catalyzed at an active site located on the N-terminal domain, and the third partial reaction is catalyzed at an active site located on the C-terminal domain. For catalytic turnover, the central domain swivels from the concave surface of the N-terminal domain to that of the C-terminal domain.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal domain contains the HPr binding site, the central domain the pyrophosphate/phosphate carrier histidine, and the C-terminal domain the pyruvate binding site.
Sequence:
MSVTGQDNKELQQEFVIVGEPIVPGIGLGKALLLGKSSLRIRELTLPQEEVEHEISRYYKALKRSRSDLAALEKEAKGKQGYQEIASILQAHLEIIKDPLLTEEVVKTIRKDRKNAEFVFSSVMGEIEKSLCAVQKTTATRVDRVQDIHDISNRVIGHLCCQHKSSLGEFDQNLIVFSEELTPSEAANANPEYIRGFVSLEGAKTSHTAIVSLAKNIPYVANFTTELWDTIKEFSGTLVLINGDKGEITFNPQLSTIQTYYRKQASVSVTVPVQVQTGKNLPLISLSAQIVSTEELPMIERESPGTSVGLFRSEFMAFSLGRLPCVEEQADQYAQLVQFQCSDIHVLRLFDFGEDKECPCISSSHRSVRWLLEQEKVLKEQLQAIAIVSRIGRLKVLIPGVIDASEIALVKRLFQEEIRLLKGISENILWGSMIEIPSAVWMIEEILQESSFVALGTNDLAQYTLGTSRERSLLGERSRVPHPSVIRMIHHVVEQAKQKNVPVSVCGEMAGDPALLPMFLGLGVKELSAVIPAINSLKMRLLDLNSRECSRLTKQLLRAKTYEEVHQLLYV
The following text describes a protein:
Function:
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MATDGTNINSWVYRGEGNACLAVGNVVSKQVYLLMKVKDRLSSDRRHADAKRTVQNDVGYGRFVMRPLIGAQFVPVGEVVCVPEEFLSQIEEKMREYRSSRRLSEKLDPAGFAVRLPDACKLPTVDSCGQGPVVCVEVKPKTGFLPEIVTIPDVHAVRRSVCRYCMQQCLKLCQGKIKERSQYCPLDLFSGTASRMVYAIKALVQNPQNNFKVFEDGNLIYSGGTENHWQPLQDCLTALFAGENEDIDCTGDSGTQTNNLLVDRFAELLFKVLVYPVDDPNSCYGNTPPSTTPECCTESTCKAQRQGGSQHGLVPDSVLFNILHTQQLDVLDIEGIYPLYQRLVAHLETHPEDRGRWCLEGPYDNAQWTMTHSAVEKCRDNIQSMESVVMLVKAFLVSLTAKDCSVMVTIQRVENGTDVMLPVMTDSVGNKFMFNIQVVDTKPKPLHRIQKYFSLNKDIVQAYVRTIGDK
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
MGKATMNIKRQHSTNVTTAALASVLMLLLAAAGSVAAQGRGGGGGYGGGGGYGGGGYGGGGGGYGGGGGGGYGGGGGYGYDGGYGDYGQGGGGGGGGMGPPGGEGLSMEYYSMTCPYAAEIVRDVVSAALAKDPTLAASLLRLHFHDCFVRGCDASVLLDSTKAHGTAEKDALTNKSLRGFEVIDAIKAALEAQCPGTVSCADVLAFAARDSVYMAGGPYYDVPTGRRDGSLSRADDTSALPAATLKAAELIKVFVGDHGFTVPELVALSGGHTLGQAHCANFKNRLSGFGKAGNGVDPTLEAGMAASLAKTCKAAGDGGTAKLDATSNAFDVEYFKGLQTRRGLLTSDQTLLTGSPETAMYVNQFAESPDAFFETFVQGMGRMGQLDLNPDGNVRLNCRALN
The following text describes a protein:
Function:
Catalytic component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is the essential ATPase of the complex. It is a DNA translocase capable of nucleosome remodeling. Required for full expression of early meiotic genes. Essential for mitotic growth and repression of CHA1 expression. Also involved in G2 phase control.
Miscellaneous:
MISCELLANEOUS: Present with 1990 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Note=Localizes to centromeric and flanking chromatin. Association of the RSC complex with these loci is dependent on this subunit.
Sequence:
MLQEQSELMSTVMNNTPTTVAALAAVAAASETNGKLGSEEQPEITIPKPRSSAQLEQLLYRYRAIQNHPKENKLEIKAIEDTFRNISRDQDIYETKLDTLRKSIDKGFQYDEDLLNKHLVALQLLEKDTDVPDYFLDLPDTKNDNTTAIEVDYSEKKPIKISADFNAKAKSLGLESKFSNATKTALGDPDTEIRISARISNRINELERLPANLGTYSLDDCLEFITKDDLSSRMDTFKIKALVELKSLKLLTKQKSIRQKLINNVASQAHHNIPYLRDSPFTAAAQRSVQIRSKVIVPQTVRLAEELERQQLLEKRKKERNLHLQKINSIIDFIKERQSEQWSRQERCFQFGRLGASLHNQMEKDEQKRIERTAKQRLAALKSNDEEAYLKLLDQTKDTRITQLLRQTNSFLDSLSEAVRAQQNEAKILHGEEVQPITDEEREKTDYYEVAHRIKEKIDKQPSILVGGTLKEYQLRGLEWMVSLYNNHLNGILADEMGLGKTIQSISLITYLYEVKKDIGPFLVIVPLSTITNWTLEFEKWAPSLNTIIYKGTPNQRHSLQHQIRVGNFDVLLTTYEYIIKDKSLLSKHDWAHMIIDEGHRMKNAQSKLSFTISHYYRTRNRLILTGTPLQNNLPELWALLNFVLPKIFNSAKTFEDWFNTPFANTGTQEKLELTEEETLLIIRRLHKVLRPFLLRRLKKEVEKDLPDKVEKVIKCKLSGLQQQLYQQMLKHNALFVGAGTEGATKGGIKGLNNKIMQLRKICNHPFVFDEVEGVVNPSRGNSDLLFRVAGKFELLDRVLPKFKASGHRVLMFFQMTQVMDIMEDFLRMKDLKYMRLDGSTKTEERTEMLNAFNAPDSDYFCFLLSTRAGGLGLNLQTADTVIIFDTDWNPHQDLQAQDRAHRIGQKNEVRILRLITTDSVEEVILERAMQKLDIDGKVIQAGKFDNKSTAEEQEAFLRRLIESETNRDDDDKAELDDDELNDTLARSADEKILFDKIDKERMNQERADAKAQGLRVPPPRLIQLDELPKVFREDIEEHFKKEDSEPLGRIRQKKRVYYDDGLTEEQFLEAVEDDNMSLEDAIKKRREARERRRLRQNGTKENEIETLENTPEASETSLIENNSFTAAVDEETNADKETTASRSKRRSSRKKRTISIVTAEDKENTQEESTSQENGGAKVEEEVKSSSVEIINGSESKKKKPKLTVKIKLNKTTVLENNDGKRAEEKPESKSPAKKTAAKKTKTKSKSLGIFPTVEKLVEEMREQLDEVDSHPRTSIFEKLPSKRDYPDYFKVIEKPMAIDIILKNCKNGTYKTLEEVRQALQTMFENARFYNEEGSWVYVDADKLNEFTDEWFKEHSS
The following text describes a protein:
Function:
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MEKELRIIISGGGTGGHIFPAVSIANAIIELRPDAKILFVGAEGRMEMQRVPDAGYKIIGLPIAGFDRKHLWKNVSVLIKLARSQWKARSIIKNFRPQVAVGVGGYASGPTLKTAGMMGVPTLIQEQNSYAGVTNKLLAQKAKAICVAYDGMEKFFPADKIIMTGNPVRQNLTKDMPEKGAALRSFNLQPDKKTILIVGGSLGARTINNTLTAALATIKENNDIQFIWQTGKYYYPQVTEAVRAAGELPNLYVTDFIKDMAAAYAASDLVISRAGAGSISEFCLLHKPVVLVPSPNVAEDHQTKNALALVDKQAAIYVKDSEAEAKLMDVALNTVADDRKLKELSENIAKLALPDSARIIAQEVIKLAEAEN
The following text describes a protein:
Function:
Alpha-galactosidase involved in the degradation of simple oligosaccharides like melibiose, raffinose and stachyose, and of polymeric galacto(gluco)mannans.
Subcellular Localization:
Secreted.
Sequence:
MSPSAAVLIPLAAAVLLRPVVGQTQCGGNLYTPGTLNFTLECYNAFQDCVAQFEANASQVDCNDGKGNLFMQQQANLGASPGSQNNDAIIAFQDIRDLCLLSGSTTATWGYSDNQWYWAAAEDACYTNDPTRTDVVKTHPAPFCIQNRDSSLPECYPQPDATPPGGPLKVIKTAKTRNGFKSSARGWNTYGVQALVNGSQVVPSFAGQSGLFYTQKFVETQCGVLARPEFKKAGYDLCSLDSGWQATTAVDQHGRIIYNTTRFNLPELASWLHKRDLKLGVYITPGVPCLAHNQTILGTNIKIKDVLNGNNDQINCDFDFRKDGVQQWHDSVVAQWASWGVDMLKLDFLTPGSPSNGANLACDSSDAVRAYQKAIKKSGRKIRLDISWKLCRNETWLPIWSDLAESMRTDQDLDNYGTNTLMAWQVGQRAIENYRQYIGLQAQRNVPLTIYPDMDALFTVNPEHLAGVNDTIRYTVQNHWLGAGANLIIGGDMEQVDALGLKLTTSKQSIDAADFFAKYPMQPRNPGTGSNAAKQLQAWIGGPSDDHEAYVLIVNYGPDLGNGGFSTKLYGKQKVTVSLKDLGISGSAWTFTDIWSGKSSRVTGSYSAWLTEGESQLLRLKRTH
The following text describes a protein:
Function:
Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells. Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK. In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation. Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses.
Subcellular Localization:
Cytoplasm.
Sequence:
MDFRSIPSCSEVSCWSPEALIEYFRAHNLRDCEKLVKKQGITGKRFLEMTENEIQKFPKVAVPMLIKIQQHMNKKDEKRGFFQKKTAIPRFPQETEFIPEDKEFSDSDSFEEDYESPNEFDDDDYERPASENEEDENENGDYEPPPPNIEDAHPPIFQLKPNVTNSPYADREFGNSTKNPPEPPKRPGNPGLPPNRGHTFPGYSPSSNQENRANTLGPSIDRTIKPSFEMTYPPNVGRGKPPIPGKIQTGHAGISQQASEKLSNLIKPPVPIERNNQPFERRIPSPRPSLPMDKRFNPEEDAPKRQVPPPGGLGFSSNTFPPRPSAKNSFPGLPVTEGPSPPGPAPPPHKPGNMNRSFSEGTCNGRPPAPIPTSYNQTSATEKESLSQDQWYTGNISRSEAETALRSINQDGTFLVRNSSKSTASHPYVLMVLYRNKVYNIQIRQDQTNGLYMLGTGLRGQETFTSVEEIIDYFHKTPLLLIDGKDQSSRQHCMLTFAAGCCLT
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEVAFQAKLKANDAGETVLDAEWFAKRLEDFKDVHKQPPLDLVGWFTLGPRSGPQPHILPIHSHISEFYTESPLLVLFHPEDAFSEATAAGKLPLTLYEPISENVTSDPNDKAMDIDGAVQARSTKFKELVYTIETGEAEMISVDFVARGGGNATAVEGTAAPKAGPSKVDEAAGKKSSSRGKQKEKKEDKEKDAPIDESLVMTAEDDEILSSLTAKMNAIRMLSRRIQLLRTYLDTLPPSYLSDPSLPLAPTVDTQNQLPLNHSILRSISATLSRINILAPPDADAFTLESQQEASDVQLVNLLSSITNSVSAAKELGRKSHIVEHAKSQGKNRMGMGMMGGYGGDASGGGAYFNTVMGGSGGSGAACPSKKDVIMGIVPPWRYADEDPSGAVVIGWYVQVLSIAILVFIWPIFIILTPIMVPLCIIGISIHFFAWLYRTIRDQGIRGPPREIYDFLRWLRRDLRDAWLDFCDAFRELMHSWR
The following text describes a protein:
Function:
Catalyzes the hydrolysis of unsaturated hyaluronate and chondroitin disaccharides. Also degrades unsaturated heparin disaccharides. Releases 4-deoxy-4,5-didehydro D-glucuronic acid or 4-deoxy-4,5-didehydro L-iduronic acid from chondroitin disaccharides, hyaluronan disaccharides and heparin disaccharides and cleaves both glycosidic (1->3) and (1->4) bonds. Prefers sulfated glycosaminoglycans compared to unsulfated glycosaminoglycans. Probably required for mammalian cells invasion through the degradation of extracellular sulfated glycosaminoglycans such as chondroitin and hyaluronan.
Miscellaneous:
MISCELLANEOUS: Ser-365 and Ser-368 bind the sulfated group in the substrate and determine the preference for sulfated glycosaminoglycans compared to unsulfated glycosaminoglycans.
Sequence:
MMKIKPVKVESIENPKRFLNSRLLTKIEVEEAIEKALKQLYINIDYFGEEYPTPATFNNIYKVMDNTEWTNGFWTGCLWLAYEYNQDKKLKNIAHKNVLSFLNRINNRIALDHHDLGFLYTPSCTAEYRINGDVKALEATIKAADKLMERYQEKGGFIQAWGELGYKEHYRLIIDCLLNIQLLFFAYEQTGDEKYRQVAVNHFYASANNVVRDDSSAFHTFYFDPETGEPLKGVTRQGYSDESSWARGQAWGIYGIPLSYRKMKDYQQIILFKGMTNYFLNRLPEDKVSYWDLIFTDGSGQPRDTSATATAVCGIHEMLKYLPEVDPDKETYKYAMHTMLRSLIEQYSNNELIAGRPLLLHGVYSWHSGKGVDEGNIWGDYYYLEALIRFYKDWELYW
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MDRLEERNIKKGEREMEEARKEEERKEEAGDRNTQEPQQGQGLSLSLANGSDSGRSGMLPMSNPSANPTQLTIFYGGSVCVYDSVPPEKAQAIMLIAAAAAAAAATKGSAATAFNPPMVHTDTVAPAAVFSPVLTRSPSLQSTSVAAGQAQVVADPSSISKLQADLPIARRHSLQRFLEKRRDRVVSKAPYSPAKSFDGMESAGMEMTADGKQGARPSILKGWGAAKSEV
The following text describes a protein:
Function:
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.
Sequence:
MDQDLSVCEQEYRKLLDPEEPLFSRTRELYRLKESILRTPAGVHVLAKAVDTTNSVLLQHELVYNLGQSAMVEACPHLERFIRAVGKYDIVTRHEAVEALGAIGDPACIPLLRHFMEPANEPEAAIRESCELALKRIEMLEEKGKEAVGPAANCPFVSIDPAPAFNGTNTGGSAPYTVSELENLLCDTTGAVSLWLRYQAMFTLRNIGTPEAVAALSRALRQDNTSALLRHEVAFVLGQLEHPASQPALLDALRDEHEAPMVRHEAAEALGAIADPKTLPALEEYAKHKEAIVRDSCVVALEMHKYWSQFNNQRIQH
The following text describes a protein:
Function:
Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGYIGAHGVAALHRYKYSGVDHSYLAKYVLQPFWTRFVKVFPLWMPPNMITLMGFMFLVTSSLLGYIYSPQLDSPPPRWVHFAHGLLLFLYQTFDAVDGKQARRTNSSSPLGELFDHGCDALACAFEAMAFGSTAMCGRDTFWFWVISAIPFYGATWEHYFTNTLILPVINGPTEGLALIFVSHFFTAIVGAEWWAQQLGQSIPLFSWVPFVNEIQTSRAVLYMMIAFAVIPTVAFNVTNVYKVVRSRNGSMVLALAMLYPFVVLLGGVLIWDYLSPINLIATYPHLVVLGTGLAFGFLVGRMILAHLCDEPKGLKTNMCMSLLYLPFALANALTARLNAGVPLVDELWVLLGYCIFTVSLYLHFATSVIHEITEALGIYCFRITRKEA
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MMDFLNSFKSLVKVEQIRTDNNVFRLHYKLTVIMLIVFSILLTSKQYFGDPINCKVEENRDIVETYCWIHGTYIRRDTLSGKSGFIPGLGPDNRDIRPWMRSPDDKIIWQKYYQWVCIVFCFQALLFYLPRYLWKTWEGGRLRLLVSDLNTPLVTASWNPTTKSQMIQYIINGKYFHTLYAIRYVVCEILNLANVILQIFLMDTFLGGQFALYGFKVFANGDINAMNEVFPKLTKCQYRFYGPSGSEVNRDALCILPLNILNEKLFIVLWFWLFFLSGVTFLSLIYRFVVVCVPKLRVYLLMAQARFIGSKQATSIIQKFSYGDFFVLYHVGKNVNPIVFRELVLGIYETLKDKNPYVYPGVEVNTI
The following text describes a protein:
Function:
Transcriptional repressor.
Sequence:
MLFLVISQTTSFMITVRQFTFTIFKFQFMATSNVSSRVNELLEAVKKEFEDICQKTKTVEAQKDDFEYKAMISAQINEMALMKQTVMDLEMQQSKVKDRYEEEITSLKAQLEARRKEIASGVVPQSSKTKHGRNSVSFGKYGNAGPFNSDNSSKPLILNNGSSGGTPKNLRSPAIDSDGTVLAPIQTSNVDLGSQYYSSPHVRPAVGATMAGSAMRTFPSNLPLGHPPPPSDSANSSVTPIAAPLVVNGKVSGNPPYPAEIIPTSNVPNREEKDWTVTSNVPNKEPPISVQLLHTLEHTSVICYVRFSADGKFLATGCNRAAMVFNVETGKLITLLQEESSKREGDLYVRSVAFSPDGKYLATGVEDQQIRIWDIAQKRVYRLLTGHEQEIYSLDFSKDGKTLVSGSGDRTVCLWDVEAGEQKLILHTDDGVTTVMFSPDGQFIAAGSLDKVIRIWTSSGTLVEQLHGHEESVYSVAFSPDGKYLVSGSLDNTIKLWELQCVSNVAPSMYKEGGICKQTFTGHKDFILSVTVSPDGKWIISGSKDRTIQFWSPDSPHSQLTLQGHNNSVISVAVSPNGHCFATGSGDLRARIWSYEDL
The following text describes a protein:
Function:
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.
Sequence:
MDIFYKKIKANVTPEVLAQLHSKKIILESTNQQQTKGRYSVVIFDIYGTLTLDNDVLSVSTLKESYQITERPYHYLTTKINEDYHNIQDEQLKSLPFISGYVGTCSFDLVRHEFPKLQSIQLEDHKQHDVRLYMVEQVYVFDHYKDELYIIATNQFSNSTKSDLENRVIKSIEDLTKIQPFMPTQDFDFKTKEIQSNISEERFIEMIQYFKEKITEGDMFQVVPSRIYKYAHHASQHLNQLSFQLYQNLKRQNPSPYMYYLNIDQPYIVGSSPESFVSVKDQIVTTNPIAGTIQRGETTQIDNENMKQLLNDPKECSEHRMLVDLGRNDIHRVSKIGTSKITKLMVIEKYEHVMHIVSEVTGKINQNLSPMTVIANLLPTGTVSGAPKLRAIERIYEQYPHKRGVYSGGVGYINCNHNLDFALAIRTMMIDEQYINVEAGCGVVYDSIPEKELNETKLKAKSLLEVSP