lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis. Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1)to a more potent estrogen, 17beta-estradiol (E2). Converts moderately dihydrotestosterone (DHT) to their inactive forms 5a-androstane-3beta,17b-diol and 5alpha-androstane-3alpha,17beta-diol. Does not metabolize progesterone. Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Colocalizes with HMGCR in a wide range of tissues during embryonic development.
Sequence:
MRKVVLITGASSGIGLALCGRLLAEDDDLHLCLACRNLSKARAVRDTLLASHPSAEVSIVQMDVSSLQSVVRGAEEVKQKFQRLDYLYLNAGILPNPQFNLKAFFCGIFSRNVIHMFTTAEGILTQNDSVTADGLQEVFETNLFGHFILIRELEPLLCHADNPSQLIWTSSRNAKKANFSLEDIQHSKGPEPYSSSKYATDLLNVALNRNFNQKGLYSSVMCPGVVMTNMTYGILPPFIWTLLLPIMWLLRFFVNALTVTPYNGAEALVWLFHQKPESLNPLTKYASATSGFGTNYVTGQKMDIDEDTAEKFYEVLLELEKRVRTTVQKSDHPS
The following text describes a protein:
Function:
Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
Domain:
The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.
Sequence:
MRIKRISLENFGSHQKTDITFADGINAIIGNNGAGKTTILEAIAYALYHRASRQQDELIRIGAPYMRVALEFEVDGRSYIVTRERGRDGGVSAELHEIIEGGKKLIQRDQSKVSSQIEAILGFSRDVFLQGIYVRQGEIQELLESQPSKRKEIIARLLGIDMLERLWEELRGVIDRLDSEIRAMDREIAAMGDVDRERLEVERKIEELKGKLSELDSQKYILQSKIEELRKLVDEIEEKRRKFIELKSKLTEIERKIEQNIRKRRELESELIRIDESLSKLPEIEKIASKFDKISRLRDLAVKLSDLRRNIETANERLDELRALEKEISDIEGRKEILVRIKEKIEEKRSKKQELTKMDMKLAGLKEKESDLLRRIDEIRVLSSLELNSLREIAEEVPEDPEDALQFCSQFSENLKKHLEEIDQNMKNLNNEIAALRERINSYSVYLGELSTNPERCPLCGSKLTMEVIEELRGNLQRSLNEMEARIPEIEERLASLNEERKLTVERIGRVDDASKKLRENLRELSSINDSLRKIEEDVRDLSEKIAELGDHLRDLDELELEYRKLISDIERVEKLKEKAEGLRSLLIGVDLDKMRQEISSLEGEIASLTKELNVVNIEEEYQRSKKAFIEFERLKGLLRERERISSILNELSEEISLDSEKVRELSEMIASLGFDEVALSEARSELNEAEERMREIIKTRGELEGIMGELKKKISELETKSEKLRKLRERKEKYENFRLKVLKIREIFSRDRGIQASLRERAKPIIERELNEIFSSFGFDYDSIELDENFTPILRRGGKAYSFDILSGGERISLALALRLAIARYLVSTKIECFILDEPTIHLDDERIESLLEALSSLQIPQIIVVTHSPRFRDIASRSILVSKVNGISNIEMLEEVMVSD
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
Sequence:
MRKQAAAEAAGSSGKKAKQAEVVKTVSPKTMVAIDPKLLQCGVCSGLLVPPIFQCTKGHITCSKCCPVVNNGCSLCKGLEDATRCHAMERLLGDLTVPCSFRARGCTEMILYSETLAHAQSCLYAPCYCPIAGCGIYAGRPSLHDHIMQDHPMLRYMVVPGVASALTMYHGDPACLVSLSSDGEMFLIVVTDDRSALAPGQSLSVIHLARKVVTRYYRIEVRTKAGLLLLYSEAQDVRRLMRAYEPTSSLFVSDAMWGPKDSPVRVDINIHPV
The following text describes a protein:
Function:
Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and lymphocytes but not neutrophils.
Subcellular Localization:
Secreted.
Sequence:
MALRMLWAGQAKGTLGGWGVICLVISLLLQHPGVHSKCYFQAQAPCHYEGKHFSLGESWLRKDCFHCTCLHPVGVGCCDTSQHPIDFPAGCEVRQEAGTCQFSLVQKSDPRLPCKGGGPDLDWGSANTPAPAAPAPHSS
The following text describes a protein:
Function:
Probable transcription factor that may regulate cell division and growth.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing ZFP10 show are dwarf, have abnormal leaf morphology, flower early and are sterile.
Subcellular Localization:
Nucleus.
Sequence:
MEKPGGFWIPKKSNKESSWEELAFAEDDAAGSLWPPRSYTCSFCRREFKSAQALGGHMNVHRRDRARLKQADDQYLFPKSSSSPEYPSHKDSDNIHETSCYTLVFNTKPNYFKTQHSCVIDLSSSSSLPYLTPSRVSSGLPGKQHTSSSPPSFVVEPSKNSKYIPSSSPWSCPSTVVEQKSCDLYEIPAMEGEKKRKTESDVPKIGHKAKLSLGNTTDLSVSMNLVIHQSFPITAHGSDEEIGRVDIRKRRRRHESPSQQSIFISSLSCKSDIITRNEESKHKGDRFEDLDLELRLGTDPPKGI
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
Sequence:
MVLRINPEHVTAWSFQRHCLLTLCSEVDSNRASQCYESALQDELPLTLASFQRNPKACPIWEHQKWVLGQMNEADWQAEIALLEKLFKLNGRNSHAWDYRRYVISIIKQSQPLETLDADVLVFSRQQIEANFSNFSAWHYRSKLLQSRLNQYNHTDDNDDSQDRKEKEEILATELEWVCEAPWIDPNDQSAWLFHRWLLSQTRDKQIQAAEYALIVELLEVEPNAKWAIAALIRARPVEYAHLLDRLIALDPLRRQRYLDLANPTAELD
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MHMATMIGSHLTQGEGGDGHGSARTLKCSFCDKEFLCKSKLNRHLRTHTGERPYSCEACSKQFRQLGHLSMHMRTHTGEKPYRCEECSKQFSTLSELKMHIRIHTGEKPYTCDHCNKGFSQLAHLKTHMRTHTGETPYRCDECSKQFTTLTHLKSHIRTHTGEKPYRCEVCSQQFSELSNLKRHTRTHTANR
The following text describes a protein:
Function:
Putative transcription factor.
Subcellular Localization:
Nucleus.
Domain:
The homeodomain differs form the typical one by having namely 4 instead of 3 extra amino acids inserted in the loop between helix 1 and helix 2.
Sequence:
MDFDDHDEGDGDEEMPPMPLSSGYDAPMQPGLGGGGGGVPKPGGGVGGGGGGGGGGGGGGARYRECLKNHAVGIGGHAVDGCGEFMASGEEGSIDALRCAACGCHRNFHRKESESPTGVGPAEPSAVSPAAISAYGASPHHQFSPYYRTPAGYLHHQQHQMAAAAAAAAAAAAGGYPQRPLALPSTSHSGRDEGDDMSGMVGPMVIGPMVGMSLGSAGPSGSGSGKKRFRTKFTQEQKDKMLAFAERLGWRIQKHDEAAVQQFCEEVCVKRHVLKVWMHNNKHTLGKKAP
The following text describes a protein:
Function:
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Subcellular Localization:
Cytoplasm.
Sequence:
MQHLVLIGFMGSGKSSLAQELGLALKLEVLDTDMIISERVGLSVREIFEELGEDNFRMFEKNLIDELKTLKTPHVISTGGGIVMHENLKGLGTTFYLKMDFETLIKRLNQKEREKRPLLNNLTQAKELFEKRQALYEKNASFIIDARGGLNNSLKQVLQFIA
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MAATVKQHVQLALSLPPRLRTFLARYPPASILPAGADPETHKTPYQEESPNPFMPTKHPITGKWHNPKYSLRRQAELVKLAQEHGVEELLPFTRKLNEEKLRKRVELGLRVKGTGVGEKVKGHKHERTLVAKMEKRREAMLAMPDLIREWKKVGKRNWTKFPK
The following text describes a protein:
Function:
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.
Subcellular Localization:
Nucleus, nucleoplasm. Nucleus, nucleolus.
Sequence:
MASSFNEETAKKLLTQVEFYFSDSNLPTDGFLNREVTKSKDGLVSLPLVCSFSRMRNLLGLGNINREDIPPRIVEEVANLLRTSDFLKVSNNGQRIGRGTKLSKPEEVLEQVHRRTLAASPFEYSIKMEDVSSFFSQYAKVNSVRLPPNIADKRRFCGTALVEFSSEQDTQDILRQSLVYAGADLVLIPKSDFDCQRENMIKQLGKSESHNEFRRGQIVKFALKWIASEEKVTNKEKPSALKNKIKEKEDKETGIADREKENGDNSCASLCKDNTDQLVVPPWNNSNSVSSEVLKDLFQRFGSVEHIEYSGGLDSGYVWFTDSETAMKARAAVEFVGGLVVKNNFSVALEAINGEMERELWKRLSSAELEGGKEGHKKEKGKDECFENVQPTKKARKEP
The following text describes a protein:
Function:
Odorant receptor for acetic and propionic acid. Functions as part of an olfactory receptor complex including the ionotropic receptor coreceptor Ir8a.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, dendrite.
Sequence:
MQLVQLANFVLDNLVQSRIGFIVLFHCWQSDESLKFAQQFMKPIHPILVYHQFVQMRGVLNWSHLELSYMGHTQPTLAIYVDIKCDQTQDLLEEASREQIYNQHYHWLLVGNQSKLEFYDLFGLFNISIDADVSYVKEQIQDNNDSVAYAVHDVYNNGKIIGGQLNVTGSHEMSCDPFVCRRTRHLSSLQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDELIRFLSQENDTHIDSLARFGFHLTLILRDLLHCKMKFIFSDSWSKSDVVGGSVGAVVDQTADLTATPSLATEGRLKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVWYLFGGVLSLIGVLLWITFYMECKRMQKRWRLDYLPSLLSTFLISFGAACIQSSSLIPRSAGGRLIYFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQLAESSLTVGLEPLPFTKSYLNYSRLPEIHLFIKRKIESQTQNPELWLPAEQGVLRVRDNPGYVYVFETSSGYAYVERYFTAQEICDLNEVLFRPEQLFYTHLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHCVAQNFVITVGMEYVAPLLLMLICADILVVVILLVELAWKRFFTRHLTFHP
The following text describes a protein:
Function:
Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
Sequence:
MSTEAPVLGIIIGGAPAPGLNGVIASATFYARQLGWKVIGFHDGYLHLATGSLEEVKANTLELNEDFVAPHLSTGGSIIRPHRYDPTKSNKEIHNVLRNLKEFHIRYLIIIGGNDKIATTHIITSGLDPAQMQVIAIPKTIDNDISLPYNTDTFGFHSARKFCSELVMNLAVDARSAPRWFIIETMGRRSGHLALSVSEATAAHLCIIPEDFKGRQVTLKEICDVFEGAILKRYLAGKPYGVCIITEGLIHYLPKEEIESLFKDGIVQYTAEGQLNLDEAEISRAIRNEMNNRLSKMGLDVRVNPKKIGYELRCMDPISADMCYTRELGAAAIEGFLNNHSNVMVVWENGNATYVSFRSLMNEEDGQIYPRLVDTKSQNYRISREYGWQVKKCDLDDTEKVEKLAKIAKITPEEFHKKFDPIMDDPAKY
The following text describes a protein:
Function:
Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MDEDNKKQLCLIDEGINSLHDLKLDPKLTILNLHCNRIKQIENLLFLHQLYHLDLSSNSITQIAGLDSLVSLRILNLACNKIKVVENLQNLRLLTKLNLAYNEIDDVSGFQDMAGPDYRISHIDLRANFIRNLSHLINCISNLSNIRELQFQHGSEELSDNPMCKQDGYREKIFQALQPLEILDGFDRSGKLAAEFDNKDVPGVEEYLEYLMSTSSSSSVKEAAFQVKTPKINAAIDKFYQRGTKLISEVEDNKFQKEYDLNEDTDGIDDQLPPAMKPLIVIKNEKKSIISKTIRKSSENTAESTDENYAKYWSLQTTSASDDRRNNLQRETSSKENIESDHEKFNRHMEKKKPSLKKSNLRKTKSERLRRPQPLKMNIVHLGDNRDSIDKEGSIPANITILKELDAEKERRWKAEMAARKLVDHIQNLQRKLSASEKTRYLAIDTSAKLQRIVEKEHNEKIEEQQKLLELQSNLEQVQQQLEACKASEEDRKSEKESMEKAYANLEISAREQFLAKDKDIKVLQDKVRDMSTLVAEANAAKDSYQKKYAELEKTIVDQAEENRKQMSKMISRDSSEFQEAINRERVHERERFDILVNQMQERIATPHGRYACILLSCLNPFLTTFISNVKIAKINSRQLLKRLKEKDREIADLNEWINKAVRLDAEEYDSLSLQFERCVSERNSLKLDYEKKAASENRLKSLLSRLVKMTEEQRTRLNEVKLQNSELKRRMTECEKRFTSQINLTTLIEKNCKELQEDNMKLTTKVTRLRGENEGLKNENERLRNEVADKGQLTRMKYFS
The following text describes a protein:
Function:
Monoterpene synthase that catalyzes the formation of (3R)-linalool from geranyl diphosphate, but not from isopentenyl diphosphate, dimethylallyl diphosphate, chrysanthemyl diphosphate, farnesyl diphosphate, (+)-copalyl diphosphate or geranylgeranyl diphosphate.
Subcellular Localization:
Plastid, chloroplast.
Domain:
The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
GNAYMRIYSTKTTRITANATVNAADTHVRRSANYKPSSWSFDHIQSLSSKYTGDDYVARANTLKDAVKTMIRKSGNSLRTLELVDELQRLGISYLFEEEISNLLETIYYNYYKFPENWNKINLNLKALGFRLLRQHGYHVPQEIFLNFKDKNQNLNSYLLNDVVEMLNLYEASYHSFEDESILDDARDITTKYLKESLEKIDGSIFSSVTHALEQPLHWRVPRVEAKWFIELYEKKNGMSPTLVELAKLDFDMVQAIHLEDLKHASRWWRDTSWDTKLTFARDLIVENFLWTIGFSYLPNFSRGRRTITKVAVMITTLDDVYDVFGTLGELEQFTDVINRWDIKAIEQLPDYMKICFLGLYKSINDITHETLANKGFLILPYLKKAWADLCKAYLVEAQWYHRGHIPTLNEYLDNACVSISGPVALMHVHFLTSVSSIEEIHQCIQRTENIVHYVSLIFRLADDLGTSLGEMERGDTLKSIQLHMHETGATEPEARSYIKLLINKTWKKLNKERATVNSESSQEFIDYATNLVRMAQFMYGEGDEDFGLDVIKSHVLSLLFTPIQGI
The following text describes a protein:
Function:
Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding.
Sequence:
MLLKSSTHSAKEHSLGRKGFPLRSSGLGARGYKAVTFPQLSSRGILQQRSCFTNSSTEEVAEETTAVEKRKVVDVIMNGAHHARGDVAVWKASIESSAPLLGDTGTRLEIVVIDQDTDRRSPPISVDDWRAPVLEIGPGSSTARSGGSSGSSSSGWKREGRLPLPADFRTPGAVLVRKLATAEGDSSVDFIGTIKLVSANKVFHFPAQSWVSSEHGWRVFFEGTAYLPAHTPPSLRDERQRELQALQGTPADRTQPRRPADRIYWYQTYDDLSSAGEGGYRPALGADVRRPYPRRIATNRGATPGTPDRELPPPKGEKPWLPYDEQFSFDKAADFNGDTLTAALPAAFSFIAEAGDQRHLTWLNLLPTAVRGLVNNLLRAVFKYAEPPAANFDNFEDVLAFFGVDADSRGSSMSPTHLYPAGAGAAMKGFGAAHDPHKPAPFKTASGAWDFRLDSTAAAAINNQIAADRVGPVYDSATGGPHAGASNTATATTAFAATAAATAAGAPAAAISAPPQPGAPSLIGRLGSAVWQRLTNDPSHDINDLLYFPVPRVLDGRPDAWYADEEYGRQALAGFHPTAITALKQLPEAFGSAIRPHHVQAELQGSTLEQLVAEAAAGAKPRLYLIDHWDLSAYWQEAEEEAEAARKAGRKPSSAVQHAGRCLFYLRKDEATGEDAALVPIAIELAHPGTHKASNGTTAPLPPTAGLVYARSDLVASPKTLAVWRLAKAVFRSLDSSIHQLVAHFNRTHATMEPFLIAMRRQMSVMHPITKLMLPHFRYTLNINRNARASLINAGGIIEKTFSAGPFAMRLASAVYGKSWTFAGQALPVDLRERGMVDAEGRPWLDYPFAIDGLGTWAALTAYFEEYVALYYAAGDAAVVEDAELQAWWNEVKIEGHPDLVAFGLKTEQQVWGFTGPIARRSDLVHVLATIAWLASGHHAAVNFGQYDFTGLVLNASSLVRRPMPAPGDAAYQELTGAALGPPQEKVFMTYLADPFSAVQVLATVKLLSAHARDEHTLDEANDFIVDPAARAANRNFIAAVKHLESVIETRNADPTNWARYGLAAGTAAPLPYTLLMASSPPGVTMRGVPYSVSI
The following text describes a protein:
Function:
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide (By similarity). Can also use pimeloyl-CoA instead of pimeloyl-ACP as substrate. To a lesser extent, can also utilize D-alanine instead of L-alanine as substrate.
Sequence:
MKAATQARIDDSPLAWLDAVQRQRHEAGLRRCLRPRPAVATELDLASNDYLGLSRHPAVIDGGVQALRIWGAGATGSRLVTGDTKLHQQFEAELAEFVGAAAGLLFSSGYTANLGAVVGLSGPGSLLVSDARSHASLVDACRLSRARVVVTPHRDVDAVDAALRSRDEQRAVVVTDSVFSADGSLAPVRELLEVCRRHGALLLVDEAHGLGVRGGGRGLLYELGLAGAPDVVMTTTLSKALGSQGGVVLGPTPVRAHLIDAARPFIFDTGLAPAAVGAARAALRVLQAEPWRPQAVLNHAGELARMCGVAAVPDSAMVSVILGEPESAVAAAAACLDAGVKVGCFRPPTVPAGTSRLRLTARASLNAGELELARRVLTDVLAVARR
The following text describes a protein:
Function:
Histone demethylase that demethylates 'Lys-4' (H3K4me) of histone H3 with a specific activity for H3K4me3, H3K4me2 and H3K4me1. No activity on H3K9me3/2/1, H3K27me3/2/1 and H3K36me3/2/1. Involved in the control of stem elongation by regulating methylation states of H3K4me3 on cytokinin oxidase (CKX) gene family, which may cause increased expression of CKX genes and reduced cytokinin levels. Prevents ectopic retrotransposition by regulating the levels of H3K4me3 in two non-LTR retrotransposons KARMA and LINE-1 (L1) and reinforcing their repressed states.
Subcellular Localization:
Nucleus.
Sequence:
MMGVTTTLNEDTEPSIPPGFGPFATLPLWGIHNDAKPAVTHSTPVQALQSIRKDSEECQPSAAVSRSDTPCSTSGTQTCRKSLRNRPPIDYSRFEHISDEDSDVEIVEKDVSSTRRRQQLPKGVLRGCAECSDCQKVIAKWNPAGARRPVLDEAPVFYPTEEEFEDTLKYIESIRPMAEPYGICRIVPPSSWKPPCLLKDKSIWEGSKFSTRVQKVDKLQNRKSSKKGRRGGMMKRRKLAESEENSATAHTQTGMQQSPERFGFEPGPEFTLQTFQKYADDFSKQYFRKDTSMDSVPSVEDIEGEYWRIVEVPTEEIEVIYGADLETGTFGSGFPKLSPETKSDAEDKYAQSGWNLNNLPRLQGSVLSFEGGDISGVLVPWVYVGMCFSSFCWHVEDHHLYSLNYMHWGAPKLWYGVPGKDAVNLESAMRKHLPELFEEQPDLLHNLVTQFSPSLLKSEGVHVYRCVQHEGEFVLTFPRAYHAGFNCGFNCAEAVNVAPIDWLPIGHNAVELYREQARKITISHDKLLLGAAREAIRAQWDILFLKRNTADNMRWKSICGADSTIFKALKARIETELVQRKTLGVPAQSRKMDAEFDSIDRECALCYYDLHLSASGCPCCPEKYACLVHAKQLCSCDWDKRFFLFRYDVNELNILADALGGKLSAIHRWGVSDLGLSLSSCVKREKVQDSKTVRRLTDGPRRSYMSQASAVSLVSSSTSNEQKDEGNKIMKIASPQTNNVCPSVEQRKSENISPLKEPCVRNELSCTTNSDSNGLQYNGGLGGHKGSAPGLPVSSSPSFSSNVATRPISTSSVSMKIVQGLVASKSCIQASSRTGDSRSLLGEHHNRSPAMIHDGTNMKSSLESSNNSCRLIASDYNATPCHSSKDQVLVTPGTNASVVTLKDSSQVHSASSQQFVRTGPWTQSASHEASSPSTSALKPSLDPPAMKNLYGGFTQGSAHPGPPSFSNQQPNDGRLQRTSESLPGVEARARGHPTVTAQPALEIHSRNGGAQKGPRIANVVHRFKCSVEPLEIGVVLSGRLWSSSQAIFPKGFRSRVKYFSIVDPIQMAYYISEILDAGMQGPLFMVKLENCPGEVFINLSPTKCWNMVRERLNMEIRRQLNMGKSNLPTLQPPGSVDGLEMFGLLSPPIVQAIWARDRDHICTEYWRSRPHVLIEDPNNRHMLSQGPPLLALRGLIQRANRDELQVLRSLMTNSNNLDDSSRQQAAHIIEEEIAKQLC
The following text describes a protein:
Function:
Involved in protein synthesis. Involved in microtubule stabilization (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MKLFTDIISNDEMCSDGYEMKLVEDVVYEVDAAKIVVSDGDVDIGANPSAEEAAEALENGAEQVINIVHSFRLQSTQFDKKSYLAYLKGYMKSVKAKLAESNPDRVPAFEKGAAAFAKKIVGSFNDWEFFTGESMDPEGMVALLNYREDGVTPYLVFWKDGLRETKI
The following text describes a protein:
Function:
Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAEQRKIIEQLMGSNLSNFTSRGLVHFTDRKVCRSFLCGICPHDIFTNTKMDLGPCPKIHSDKLKSDYERASYSHDYGYEWDYLEDLERHVDDCNKRIDIAEARREKTKEEEERIDELMRDIIHTDHSIEVIITEMEALAKRKLVNDAVKHFIELNRLKTYRKELYDEVISMNEIPSQASTTHQKLQVCDICSAYLSRLDNDRRLADHFSGKMHLGYAMLRNIARDLRAQLEDREKSRDKKDGEKQRDNLASFEDKISTSFVA
The following text describes a protein:
Function:
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass type II membrane protein; Intermembrane side.
Domain:
The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria.
Sequence:
MYRTISRSSSGLIRQSTARLTRQLSTTRTTPSQYNSKLLLGVLGTGALAFGYFSQQSSLIQNASTAENIEKVFEEGNAVAKDAQESLDARQEKVIKENEQKTKKAEDAKTSSESKANVADKKSNSQPEGEPEGEGKQEAAFNPDTGEINWDCPCLGGMAHGPCGEEFKEAFSCFVFSETEPKGIDCIKKFENMRSCFKRYPEHYKDELYDDGEEEASTEVVEHVVLETSEPAIEQIEQGIKEDKVKPNTKSD
The following text describes a protein:
Function:
Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MPRRAGSGQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQIGVYYIDHINKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHVKEQRLALALDEYVRLNDAYKEKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKRELSQMKQELLYKEQGFETLQQIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQERFHLDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRSNLAEKVRLSLQYEEAKRSMANLKIELSKLDSEAWPGALDIEKEKLMLINEKEELLKELQFVTPQKRTQDELERLEAERQRLEEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKLTTYLHSQLKSLSASTLSMSSGSSLGSLASSRGSLNTSSRGSLNSLSSTELYYSSQSDQIDVDYQYKLDFLLQEKSGYIPSGPITTIHENEVVKSPSQPGQSGLCGVAAAATGHTPPLAEAPKSVASLSSRSSLSSLSPPGSPLVLEGTFPMSSSHDASLHQFTADFEDCELSSHFADISLIENQILLDSDSGGASQSLSEDKDLNECAREPLYEGTADVEKSLPKRRVIHLLGEKTTCVSAAVSDESVAGDSGVYEAFVKQPSEMEDVTYSEEDVAIVETAQVQIGLRYNAKSSSFMVIIAQLRNLHAFLIPHTSKVYFRVAVLPSSTDVSCLFRTKVHPPTESILFNDVFRVAISQTALQQKTLRVDLCSVSKHRREECLAGTQISLADLPFSSEVFTLWYNLLPSKQMPCKKNEENEDSVFQPNQPLVDSIDLDAVSALLARTSAELLAVEQELAQEEEEESGQEEPRGPDGDWLTMLREASDEIVAEKEAEVKLPEDSSCTEDLSSCTSVPEMNEDGNRKESNCAKDLRSQPPTRIPTLVDKETNTDEAANDNMAVRPKERSSLSSRQHPFVRSSVIVRSQTFSPGERNQYICRLNRSDSDSSTLAKKSLFVRNSTERRSLRVKRTVCQSVLRRTTQECPVRTSLDLELDLQASLTRQSRLNDELQALRDLRQKLEELKAQGETDLPPGVLEDERFQRLLKQAEKQAEQSKEEQKQGLNAEKLMRQVSKDVCRLREQSQKVPRQVQSFREKIAYFTRAKISIPSLPADDV
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSRWFRSEHMEYISLIVNEDAAHDCLADLGKLSAIQFTDLNPDLTPFQRRYVSYVRRCDELERKLRFFGNECDNFGLKLDTAGDIDTFLESPTALLESLEVELEGYESQLKELNAYSEKLTREYNEKVELQEVLEKARRFFMTDAPRLAVSELSGGRKPGSGSNQGLLAGAHDAEARDMDMRFSSITGVVSTEEKVRFERMIFRATRGNCYVRFAPIKQPITDPESGSLIEKCVFIVFFKSLSIETKLKKICDAFFAHRYSLPDMDDAPAVDRMLTENAQELVDSRTVLLKNQDTRFRLCQMLAQHTERWTWIVLREKAVYHTLNMFKADVSGMLRGEGWVISESFEDIRMSVNRAHSEMDHNMPSHVDQVPKPWPTPPTHFTTNKFTYGYQEFVNTYGIPRYREANPALFTAATFPFLFGVMYGDIGHGLFLFCAGLYLLWNEDKNDKAKLDEMTGGLHAGRYMITMMGFFAVYAGLVYNDCFSLGLNLFGSRWAFANGEPEEGDVAEMTGQYGDGDSVYPFGLDPMWHVAQNELLFFNSFKMKLSVIFGIFQMFSGTCLKGINAIYFGKRLDFLFEFLPMVAFACSLFVYMVVLIFMKWSINWNSRMLSATYGCQPPNLITALINIALSPGVVDEPMYYGQAGIQNILLAIAGISVPVLLLAKPYFLSKEAASHAHSAHDDDDDDEEHGFGEIIIHQAIETIEFVLGMVSNTASYLRLWALSLAHSELATVFWEKAMLSTLNLNWFATFIGYGIFAGTTFGVLLMMDVLECFLHALRLHWVEFQNKFFHADGIRFAPYSFKQILSDASAAH
The following text describes a protein:
Function:
3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease. Required for both spermatogenesis and oogenesis.
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
MSRPSSVSPRPPAPGAGGGGGGGGGGPSQCGPGGGGRAKGLKDIRIDEEVKIAVNIALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKKKDGSETAHAMMTCNLTHNTKHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEAENREMSKTSGRLNNGIPQIPVKRGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQREEKQQTTLTEWYSAQENTFKPESQRQRTVPNVTDEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDVDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFSSQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSASLEFGNLDESSLVQTNGSDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAILIFLPGYDEIVGLRDRILFDDKRFADSTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHTKLLAPVNCPIADFLMKAPEPPPALIVRNAIQMLKTIDAMDAWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGTFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENVLLTGPKEKKVRFHPTSVLSQPQYKKIPPTNGQAAAIQALPTDWLIYDEMTRAHRIANIRCCSAVTPVTVLVFCGPARLASNALQEPSSFRADGIPNDSSDSEMEDRTTANLAALKLDEWLNFKLEPEAASLLLQLRQKWHSLFLRRMRAPSKPWSQVDEATIRAIIAVLSTEEQSAGLQQPSGIGQRPRPMSSEELPLASSWRSNNSRKSSADTEFSDESTTAERVLMKSPSPALHPPQKYKDRGISHPKRSADDRSDQSSVKSADSSYPSPCASPSPPPSGKGSKSPSPRPNMPIRYFIMKSSNLRNLEISQQKGIWSTTPSNERKLNRAFWESSMVYLVFSVQGSGHFQGFSRMSSEIGREKSQDWGSAGLGGVFKVEWIRKESLPFQFAHHLLNPWNDNKKVQISRDGQELEPQVGEQLLQLWERLPLGEKSTTD
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds directly to 7SL RNA. Mediates binding of SRP54 to the SRP complex.
Subcellular Localization:
Cytoplasm.
Sequence:
FASYAEQSPADKYRFICIYPAYLNNKKTIAEGRWILIDKAIENPTATKIQDVCLAVGFNVHIEKNSVLQRVES