The following text describes a protein:
Function:
Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis.
Subcellular Localization:
Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGDGGEGEDDVQFLRTEDEVVLQCSATTLKEHIKLCLAAEGFGNRLCFLEPTSNAQNVPPDLAVCCFVLEQSLSVRALQEMLANTVESSQGGGHRTLLYGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSTASGELQADASFMQTLWNMNPICSECEEGYVTGGHVLRLFHGHMDECLTISSADSDDQRRLVHYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGRYLALTEDQGLIVVDAAKAPTKATAFCFRVSKEKLDTAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAAPDPKALRLGLMKRKAMLHQEGHMDDALSLTRCQLEESQAARMIYSTAGLYNQFIKGLDSLSGKPKGAAAAGVALPIEGVILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQEEGMLTLVLNCIDRLNVYSTAAHFAEYAGEEAAESWKEIVNLLYELLASLIRGNRTNCALFSHNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDVLCSLRECEWRRSLCISFILYLILYTSLPSIRPNIFVGRAEGTTQYGKWYFEVMVDSVEPFLTAQSTHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGRVARPVASPGQHLLAAEDVVSCCLDLSVPSISFRINGCPVQGVFEAFNLDGLFFPVVSFSAGIRVRFLLGGRHGEFKFLPPPGYAPCHEALLPRERLRLEPIKEYRREGPHGPHLVGPTCCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNKRLHPCLVDFHNLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEENLKKTKLPKTYMMSNRYKPAPLDLSHVKLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRLVPYQLRPDVELGADDLAYVFNGHRGQRWHMGSEPFGRPWQPGDVVGCMIDLTENNILFTLNGEVLMSDSGSETAFKDIEIGDGFLPVCSLGLGQVGRLNLGQDVGSLRYFTICGLQEGFEPFAINMQRPVTTWFSKSLPQFEPMPPDHPHYEVTRVDGTVDTPPCLRLTHRTWGSQNSLVEMMFLRLSLPVQFYQHFRCTPGATPLAPPGPQPPGDDEVRAAEPDPDYEQLQRSAGRQGEAEGNKEGPGGASKDGAAGGPSPTGKAAMMTQAPATPALPRLPRDVVPADNRDDPEIILNTTTYYYSVRVFAGQEPSSVWVGWVTPDYHQYDMNFDLTKVRVVTVTMGDERGNVHNSLKRSNCYMVWGGDFVSPGQQGRISHTDMVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAAFVLPTNQNVIQFELGKLKNIMPLSAAMFLSERKNPAPQCPPRLEVQMLMPVSWSRMPNHFLQVETNRAGDRLGWAVQCEDPLTMMALHIPEENRCMDVLELSERLSLQRFHSHTLNLYRAVCALGNNRVAHALCSHVDQAQLLHAIEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLNEYIVPLTPETSTITLFPPGPSADPGEESPRRHGLPGVGTSTSLRPPLHFSPPCFVAAPEGAGTAEAPARFSPSIPLEVLRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFCDEDVKQILRMIEPEVFKEEEEEEEEEEEDEEEKEEDEEKGEEEEAAVEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVEALIAFSERYVDRLQGNQRCRYGLLMRAFTMSAAETARRTREFRSPPQEQINMLLHFKGGEDEEECPVPDEVRQELLDFHQDLLLHCGIQLEGEEEEIEEETTLGSRLMNLLEKVKLVKKKEEEPEDSPSLQELVSHTMVHWAQEDFIQNPELVRAMFSLLHRQYDGLGELLRALPRAYTISLSSVEDTMSLLESLCQIRSLLIGLGDSGDPPLPFFCRNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLLAKGYPDIGWNPGGGERYLDFLRFAVFVNGESVEENANVVVRLLIRRPECFGPALRGEGGSGLLAAMEEAIRISEDPARDGPGDAPEENRVHLGNAIMSFYSALIDLLGRCAPETHLIQAGKGEALRIRAILRSLVPLDDLVGIISLPLQIPTLGKDGALVQPRMSASFVPDHKAPMVLFLDRVYGIDSQDFLLHVLDVGFLPDMRAAASLDTVSDPLPTASSTAPLWRMCPDDSHQSSLAKASPTSPVRGRMKRSALIVPRASSGRAPSSHLFGNKRLPCYLLPTHAPLLPKELFLALLSPVLSAPSLWAEHHHPTGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRGLKDMELDTSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFNNHCLYFLSTPAKVLGSGGHASNKEKEMITRYVVVGARWEVLGSNLTSDISCLSLPCSPRTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQARTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKNSYVEKLRPALGECLARVAAAMPVAFLEPHLNEFNACSVYTTKSPRERAILGLPSSVEEMCPDIPDLKQLMAEIGGLAESGARYTEMPHVIEVTLPMLCNYLPRWWERGPEVPTSQPPGGPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLRSHFIPTVGRLRKRAGKVVAEEEQLRLEAKAEAEEGELLVRDEFSVLCRDLYALYPLLIRYVDNNRAHWLTEPNPDAEELFRMIAEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADSKSKMAKSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLIALAKTRYALKDTDEEVREYLQNNLHLQGKSEGSPSLRWQMALYRGLPGREEDADDPEKIVRRVQEVSAVLFHLEQVTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPRHRASNMFLESYKAAWILTEEHSFEDRMIDDLSPFPNEEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKQGPMEEGLPGGISGKGTLMLSIHLSVLLQEKEMEKQRLLYQQARLHNRGAAEMVLQMISACKGEPGAMVSSTLKLGISILNGGNIEVQQKMLEYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGMVTEEGTGEPPPHPSPWDPPPLGLPFLSLILDGLSLPDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIDEQGKRNFSKAMAVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQVGTSLIHLFSIYAENGEKEGPQEPEPEPPKKAAAPSPPRKEDAKSEGPDFWEELEVQRVKFLVRTSLTSGRDGYGLRDNSVPPSFPLFSVPYQNYLSRNFYTLRFLALFLAFAINFILLFYKVSGSGSGDFLGSGMGSGVGEEMEEEEEENMVYYFLEESTGYMEPALRGLSILHTLIAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLEKHGDIFGRERIAELLGMDLASLEITAQNEKRPEPPSGLLTWIMSIDVKYQIWKFGVIFTDNSFLYLIWYLVMSLLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLA