lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Nuclear export is mediated by emb/Crm1 (By similarity).
Sequence:
MTTYSTDSQGKFIPATQRPDGTWRKPRRVRDGYVPQEEVPLYESKGKQFAQKPALPPGLSPEVVQKAKEKRERERLRQAREEQQRKEQQNKKQQAGALPPGVLAVDGGAVGGNNDKQKPGAKQPQQHTKSSQQKSTTAAAAAVSNNSDSTVDELASALASGAQLAGADAQQLEVAKKLRKLRKKIREIEAIETKLRSTDGPKLDKDQLEKVKRKPDILQEIEELEVQYSAGAM
The following text describes a protein:
Function:
Involved in the bidirectional transport of formate during mixed-acid fermentation.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MRNKLSFDLQLSARKAAIAERIAAHKIARSKVSVFLMAMSAGVFMAIGFTFYLSVIADAPSSQALTHLVGGLCFTLGFILLAVCGTSLFTSSVMTVMAKSRGVISWRTWLINALLVACGNLAGIACFSLLIWFSGLVMSENAMWGVAVLHCAEGKMHHTFTESVSLGIMCNLMVCLALWMSYCGRSLCDKIVAMILPITLFVASGFEHCIANLFVIPFAIAIRHFAPPPFWQLAHSSADNFPALTVSHFITANLLPVMLGNIIGGAVLVSMCYRAIYLRQEP
The following text describes a protein:
Function:
tgrB1 and tgrC1 are involved in kin discrimination. They play an essential role in aggregation and subsequent development. Could function as a non-diffusible cell-cell signaling molecule that is required for multicellular development. Has both cell-autonomous and non-cell-autonomous functions. Terminal node, epistatic both to comC and tgrD1. Activates tgrD1.
Miscellaneous:
MISCELLANEOUS: The tgrC1 gene is highly polymorphic.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell junction.
Sequence:
MEKKIILLILFLFFISGYSMNPPTPIDAIYDDKSFTLIFNSNLPYSTRLILYKNEKEPRTEMAPNYFNCSLVDGERHCLFHSDEPFSRLWGSIDSKVCVRDKSNTVEDCTFDASGLVYYPKVYNLKYSKKPKTSGEDIVITGSYLRLFGGPNFLINSIDVNKPFVVKGNFSDPSFDCNNITVTFPPGSGKFRLYYDETGDNPVPFSYESPIISSSVSDSSKQIITINGDNFFTDKDLVKVSFDGIDQPNFIISVNHKQIQVNNYNRVDPGPMSVNITVDEVSIEKNYIHCFPAIITSISSVSNHLDGIVTIKGEKLSSTLNSSLTPSITIGDKVCKFIKSTTTELECKLDANELGGKNLPVNVNFGGCDSTSPNGVSFTYNIPTLSSGSYSNGIVTLIGTNLGTNNESSIQLYGDGIKNTNISQFNVSSSDEKSVTFELPHLRCRSFNINFTRSGITAKTLSISASLSVNVINRPTVSNGILNIEIYYMDCTISSSAPSITVGDSSSASPCSIPSSNSSYYETTCPTPYGTGINKQFIFKLNSETVSDQFSYAPPEVENRTISDDGTNIELHGNNFGNSTSLIKVYLNGSDISSEIQELEDHQLTIKILDSYENGPINITVDGNYMDSLFYLTLPPVIYRITNKDNKTLACGGLITVSGKNLLTSDKEFKVNVKSNNKNTTVFAQDEKILIVRDESRESSLFVTTFIGVRSGPSTTLTYIKPMISEIPTIENKIEKGILAIIRGYSFTDILNASLTVSSETVPLSCNLECSLSPNEILDDSDSSETNITNSNTDCLSCHSGSSVKNTSGVLYLLFNSTSFQYNVTIEEIKLSPSPNVSQRDVETKSSKPSNGLIIGSTIGSVGGALAIGALAYYFKIPFRVKKFIGKKF
The following text describes a protein:
Function:
Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.
Subcellular Localization:
Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex.
Sequence:
MESESAGVAQSLDPKDEPTTSPVSVDTKKENSGRDTEISSKDVSQKAERVQQLCRFYSQGRRCYYGKRCHFLHQRASGAPKDGENGTSHKEKEAKEPQQQLSENSQPTTEDLPPPSNHKPAPVRQQRARRPCRYFLSGFCAMEDRCRFLHPQEFPPVEDKHQGPKERSSFRPNAPAMRPAKSHEQVKLAELTEEVCKQLRETEIAQLMKRFPKDKLIIQEREDGQLTYYRVTVEATDPDWPFDLNEVDIMVSFPESYPQEAFTVDVPEDQDLPSLMGRHVQKASEEWLRAKHATNQLMGRVELLFRPYLRWLDRSMEKLFTEGARQLKKDIDLEKAGIQFVPYEQLKVTFFKSTSKKANTPERIVTMASGEELEEEEERDEGGEEEEEGDEEALDYDGEEGSQQVENIKTRERRRGTEIKLLGLRLGEQTATVAARQISVSLKCNRCKVDAELTLNGQVACTAQCEKCGADIRAAFRPSMLHHYSDVLGYLDLHAAVPVDLVLQDSQFSVGCLNCNKEDIIQNLTYGQNWEQNCQHCHFKLSIFVEATRFQFIQPETKNQTGAAGQYPRRYRDPAVQQGKPLPDKGACKHFKQSHRWLRFPCCGRAYPCDACHDEDQDHLMELATRMICGYCAKEQPYCNGKPCVGCGGMMTRGAFTSYWEGGQGCRNKIKMNRNDRHKYANTSKTVPKKAQKEKK
The following text describes a protein:
Function:
Probably involved in the defense reaction of plants against pathogens.
Sequence:
MKIFIQSRNLILATTIFLVFIAPIKSQDRPEDFLAAHNEARAAVGVGPLTWDVRVALYATTYANQRRGDCALKNSEGPNGEPGPYGENLAWNSASMSAAEAVEAWVNQKSDYDYNSNTCADPLTKCLSYTQVVWRNSVKLGCMLFIYKLIMIGLFGPVVFCTIFMRVFL
The following text describes a protein:
Function:
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration (By similarity).
Subcellular Localization:
Cellular thylakoid membrane; Multi-pass membrane protein.
Sequence:
MFVLTGYEYFLGFLFICSLVPVLALTASKLLRPRDGGPERQTTYESGMEPIGGAWIQFNIRYYMFALVFVVFDVETVFLYPWAVAFNQLGLLAFVEALIFIAILVVALVYAWRKGALEWS
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSAIYNLEPQPTASAIIHTTQGEIAVELFAKQTPLTCRNFLQLALDGYYDNTIFHRLIPGFIVQGGDPSGTGHGGESIYDNGALSGDLDPWPMDQRRGKNAGPHGVNFKDEFHSRLKFNRRGLLGMANEGAPDTNSSQFFFTLGKADELTGKNTMFGRVAGDTIYNLAKIGEAEVEEGGERPLYPIKITRIEILINPFDDMQKREKKPRPQQISRPTPAEKKQKKRKGGKQLLSFGDEVGDEDGEELPLPKKPKFDTRIVADLDQDDSSKQSASKKSSAKRDAKPVANDVPKREEKPEPKPVKESRRSPSPQPVAQKKEQPPKKHYSEHSSPEPEEPKKKSLLEKTNEEIAALKASMKRTIHSEPVKQEKKKSALEQLIPDTAIRGRKRRPGASSNPTREEQEALDLLKSFKAKIETAPPEKNAAQPAVNPDVEDGEQDGQADEEKVCDLHFIANCQSCKAWDKVEDNEDSGDEGWMSHKLSFAADKLGKDLSYRKKAEEELVVIDPLAKARTLKEEKKATRDAKTGGSSRAWDRGRRDRH
The following text describes a protein:
Function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Sequence:
MKRLVNISFLLNGDFLNLKDIVDKVQNGLTRIMKSEELDKLVAEIAASMTTKHPDYNILAGRLAVSNLHKKTKDKFSEVIKDLHNYTNPHYFPPSLTTSHLPLISTSLYEIVLSNSDRIDSQIDHSNDFNFTYFGFKTMEKSYLLRLNERVVERPQMMFMRVALAIHGGDLEGAFESYRMLSDGYFIHASPTLFNAGTPRANLCSCYLQPVIEDSVHGIFSTLKRCALISRGASGLGLAVHDVRAAGSYIHGIHGKSNGLVPMLRLFNDTARFISQGGNKRPAAFSIYLEPWHSDIINFLNLHKNSGVEEQRARDLFYGLWIPDLFMERVERNEEWTLFSPDVCPGLSKVWGDQFRELYEHYERSNVGRVRMAARKLWEEICTAQVETGMPYMMYKDACNRKSNQQHLGTIVTSNPCAEIIQYCAPEEVATCNVASVALNKFVSPDGTSFNFTELGKVVGILLKNLDKIIDVNHYPLKEAQLGARRHRALALGVQGLADVFQMMKMPFGSKESKKLNKEIFESIYFYALQTSCELAKKFGPHPSFHGSPASRGILQMDMWGLQQSEDRHNWSALKLDIIKHGLRNSQLIGLMPTSSTSQILGNCECFEPYTNNLFARRVYSGEYQVINAHLVKDLIRLGVWDERMRMLLMANNGSVQKIKKIPQNLKAIYRTVWEISQRDVIDMAADRSPYVDQSQSMNLFLQEPTYEKLCSMHFYAWKKGLKTGSYYLRMRPAANAIQFTVDKTKLSKNDNDDDDDDDGDVNHDDDDYVNDDDDYANDDDDYANDDDDYANDDDDYANDDDDDVGDGDIVTMT
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
MELQLYHSTTTLLLPLLLLLLLLLPSSSSSSSHGLRSADGSRAPHYRLKDPRPPKIGDGEGAATAESLIGSRPPRCDGKCAPCGRCEAVQVPVAPRADSRGGEPRRRGGLFGSAEESYTDYKPLNWRCRCADRRALDP
The following text describes a protein:
Function:
Peptidoglycan polymerase that is essential for cell division.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Note=Localizes to the division septum.
Sequence:
MEFLQNIKKNYDEWTRITPQGLLYDRALFWLFVILLLIGLVAVTSASIPYSSRLFNDPFYFAKRDAIYVLLSLLTCYISLQISSSQWEKWHAKIFLFSVILLLLVPFIGTSVNGAKRWISLGILNFQPAEFAKLALTCFLASYFTRRYDEVRSRHVSIFKPFIVMLVLGCFLLLQPDLGSTVVLFIIMSGMLFIVGAKILQFVGLIALGGILFVWLVLTASYRLKRFIGFLEPFKEPYGTGFQLTNSLIAFGRGEITGEGLGNSIQKLDYLPEAHTDFIMAIIGEEFGFIGILIVILLLGLLIFRAMKIGRESLMLEQRFRGFFALGIGFWIFFQGFVNLGMALGMLPTKGLTFPLVSYGGSSIIIMSATIGILLRIDHENRLFRIGQARLRDD
The following text describes a protein:
Function:
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality (By similarity). Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (By similarity). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (By similarity).
Subcellular Localization:
Cytoplasm. Cell junction, focal adhesion. Membrane; Peripheral membrane protein. Note=Colocalizes with EF1A1 at actin-rich regions in the cell periphery.
Domain:
The SAM domain mediates interaction with EF1A1, and functions as an autoinhibitory regulator of RhoGAP Activity; The polybasic cluster is required for activation and mediates binding to phosphatidylinositol-4,5-bisphosphate (PI(4,5)P(2)) containing membranes.
Sequence:
MARPLRAPLRRSFSDHIRDSTARALDVIWKNTRDRRLAEIEAKEACDWLRAAGFPQYAQLYEDLLFPIDISSVKREHDFLDRDAIEALCRRLNTLNKCAVMKLEISPHRKRSEDSDEDEPCAISGKWTFQRDSKRWSRLEEFDVFSPKQDPIPGSPDAVHLKSAPSHENMQTDLSDRQEVASVHSTGSLTTHAPQRGEAAPARTNSVLSVCSSGTFVGNDDSFCSLPSPKELSSFSFSMKGHEKAAKSKTHSLLKRMESLKLKGSHHSKHKAPSKLGLIISGPILQEGVDEEKLKQLNCVEISALNGNHINVPMVRKRSISSSTQTSSSSSQSETSSNVSTPSPVTRTRSLSACNKRGGMYLEGFDPFNQSTFNNVMEQNCKNRESYPEDTVFYIPEDHKPGTFPKALSNGSFSPSGNNSSVNWRTGSFHGPGHISLRRENSSPKELKRRNSSSSVSSRLSIYDNVPGSILYSSSGDLADLENEDIFPELDDILYHVKGMQRIVNQWSEKFSDEGDSDSALDSVSPCPSSPKQIHLDVDNDRATPSDLDSTGNSLNEPEEPSDIPERRDSGVGASLTRSNRHRLRWHSFQSSHRPSLNSVSLQINCQSVAQMNLLQKYSLLKLTALLEKYTPSNKHGFSWAVPKFMKRIKVPDYKDRNVFGVPLTVNVQRTGQPLPQSIQQAMRYLRNHCLDQVGLFRKSGVKSRIQALRQMNESTIDCVNYEGQSAYDVADMLKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRLQAIKAAIMLLPDENREVLQTLLYFLSDVTAAVKENQMTPTNLAVCLAPSLFHLNTLKRENSSPRVMQRKQSLGKPDQKDLNENLAATQGLAHMIAECKKLFQVPEEMSRCRNSYTEQELKPLTLEALGRLCNDDSADYQHFLQDCVDSLFKEVKEKFKGWVSYSTSEQAELSYKKVSEGPPLRLWRATIEVPATPEEILKRLLKEQHLWDVDLLDSKVIEILDSQTEIYQYVQNSMAPHPARDYVVLRTWRTNLPKGACALLLTSVDHDRAPVVGVRVNVLLARYLIEPCGSGKSKLTYMCRADLRGHMPEWYTKSFGHLCAAEVVKIRDSFSHQNTETKDTKSR
The following text describes a protein:
Function:
Involved in the regulation of plant growth.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing VUP4 exhibit severe dwarfism.
Sequence:
MESSMNNAFIMSKHETAMFTDDQNPEESSWTMYFEDFFEASSSIVDVGDFSSSSVSDAASFVATKKTLNVSKQEGSNLDIKRTRNREIPFGRHHDLEDTASSPSGSPNVYSMMNLQDNNTRHGGGIVGDDEKRVSAVPNQGGLPIDLKKKGLCLVPLSMVTNFLG
The following text describes a protein:
Function:
Acts as an effector of RABF2A and RABF2B. Involved in vacuolar transport of storage proteins. Regulates membrane trafficking to protein storage vacuoles (PSVs). Binds specifically to phosphatidylinositol 3-monophosphate (PtdIns3P).
Subcellular Localization:
Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein.
Sequence:
MIRGRSPPKHRHDGTSPLPMGMDWSPPPKKWGGRDTVWPHDPRSGWSYCVTIPSWVALPKSRSSSSDPVVFYRILVGIQSPAGVTTTRGVLRRFNDFLKLFSDLKRAFPKKSLPSAPPKGLLRMKSRALLEERRCSLEEWMLKLLSDIDISRSMAVASFLELEAAARSSFLEASQPPSTENPSTTSSVSSDQNHPSLSLPALASSSSIASDYGSDTAYETSELGSPSFGRDDVSEVGLEELTLDEDLTSPMEKIVKYSMSNIDEGLLMGESILDQLESFKKHKGQSRHITDNGSALKSASLAVDRAGSSFEADPIKVVNHIRKTSNESVGSDLSSYRGGEMSNSWAPNLLSEASLDLPSGAEAFRTMGSPSSSELQYSIGDVVLPRDQQPKLDRTLMIIQRRLVTAKTDMEDLISRLNQEVAVKEYLTTKVKDLEVELETTKEKSKENLQQALSLEKERVTKMQWDMEELRRRSLEFELQLKSQDAKLPADFMSLSAFPEKDELFRELKATKDQLNILLKQHEELEVKSKSDIKLLVKEVKSLRRSQVDLKQKLDESLQEKTEVELLLQQEMERNEHALAAKRKLLHDCQTLQSQLLECNIKIVDNNFTVDSSSISDVLDLLADSDKQIGVLLAETQQLAPAPNTLSNNDDLKKTLDHELRVVLRDIFSDNAKLRKQVNNFIRSALQTDSSSNENGNQGLPRETVLKQLFET
The following text describes a protein:
Function:
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Regulates neuronal differentiation in response to NGF by facilitating NGF-mediated activation of NTRK1/TRKA receptor tyrosine kinase and subsequent downstream signaling pathways. Plays a role in the inhibition of TNFalpha-induced apoptosis. Mechanistically, inhibits the NF-kappa-B signaling pathway by blocking phosphorylation of CHUK. Also promotes the stability of the thiamine transporter 1/SLC19A2 in intestinal epithelial cells leading to an increase of thiamine uptake process.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGCFGFLKFMMFIFNGIIFVQKDLKIVVGQPISVVQGSSANCIFQSKTSLLAQIISIIYCLEARDHFQRSNLAFLSCSCDVSESQAIYPQFFIIVLIIFIAEVAGAVVVLVFSPLAEELIRKGGEKVVEDLKTSYGSQSDITTIWNNTMKEFKCCGFNNYTDFMNSSFVNAYNMYPEQCCKSQPCNSSNVSSSAVKGCFPALVEFVKKNAVVLGAVALGIAALEIAAMVASMTMYCKISSK
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 1340 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MLHCARRYMLVRPRLLWQSGTCVARFQSSVRTPASEPSAEKGVDEWLEAINELREEFSAKEYLPETSLAPPGQSKVDLLQGSQAGSKIKPTAEQLAQWEALKSVPIPPRKNATLDHITNMIMRHGKKEKAQTILSRALYLVYCQTRQDPIQALEKSLDELAPLMMTKTFNTGVAKASVIPVPLNKRQRNRIAWNWIVQSANQRVSSDFAVRLGEELTAIAKGTSSAFEKRDQIHKTAIAHRAYIQLK
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
Subcellular Localization:
Cytoplasm.
Sequence:
MPKAEGRIFDFKGHDAIRTDFLEAIDFDGKDEYIKIETDEFSAVCPFSGLPDIGRVIIEYYPDGGKIVELKSLKYYFVSFRNVGIYQEEATKRIYEDLKNLLKTDRIRVTVIYNIRGGIKTTTQMGSLEGKKSGEVE
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNRQEGGLLTSLENLIVFTKYFGVHSLQYDTQLRKFQICKNLKLLKILWFTIVIIFNIYVSKLLTEAIPRKIFILHVGYYIYRDLYLMVLYSIIICDHIYEETTETVLNQLIQVQERLQQNDRIKILKLVLLTIICTKFGIDIFGVYKFTKTDGDISWDTILVIFNFVYISFIENLTELRFLLIFSILPVYFKHLSQDFNLSFTNPTKCNKIVKTHQELCWLARKINKTFSVPFLFLMGYYLSNMIINIIQNYYHMVFLNTAVNIFDIFQFSLALIMLFSLIIVANQCMTQANEFKKHVCKVLSKNGTNSNRKNLYAYGLQMFHEDLQINAAGFFVIEIGLIFAMISAAGTYVVIILQFLYSENQNVRSKNFEIFTNG
The following text describes a protein:
Function:
ATPase component of the type IV pilus (T4P) that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility facilitated by cycles of extension, adhesion, and retraction of T4P fibers. Acts as a molecular motor to provide the energy that is required for T4P retraction while antagonist PilB ATPase activity is required for T4P extension. Also promotes PilU retractation activity through direct interaction.
Subcellular Localization:
Cytoplasm. Note=Localizes to cell poles.
Domain:
The N-terminal region is responsible for proper localization to the piliated pole.
Sequence:
MDITELLAFSAKQGASDLHLSAGLPPMIRVDGDVRRINLPPLEHKQVHALIYDIMNDKQRKDFEEFLETDFSFEVPGVARFRVNAFNQNRGAGAVFRTIPSKVLTMEELGMGEVFKRVSDVPRGLVLVTGPTGSGKSTTLAAMLDYLNNTKYHHILTIEDPIEFVHESKKCLVNQREVHRDTLGFSEALRSALREDPDIILVGEMRDLETIRLALTAAETGHLVFGTLHTTSAAKTIDRVVDVFPAEEKAMVRSMLSESLQSVISQTLIKKIGGGRVAAHEIMIGTPAIRNLIREDKVAQMYSAIQTGGSLGMQTLDMCLKGLVAKGLISRENAREKAKIPENF
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. PGD1/MED3 is also involved in direct repeat recombination.
Miscellaneous:
MISCELLANEOUS: Present with 556 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDSIIPAGVKLDDLQVILAKNENETRDKVCKQINEARDEILPLRLQFNEFIQIMANIDQEGSKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTADNRDRSFQLLEPLSTYNKNGNAVCSTATVVSTNHSAAASTPTTTATPHANPITHAHSLSNPNSTATMQHNPLAGKRGPKSGSTMGTPTVHNSTAAAPIAAPKKPRKPRQTKKAKAQAQAQAQAQAQVYAQQSTVQTPITASMAAALPNPTPSMINSVSPTNVMGTPLTNMMSPMGNAYSMGAQNQGGQVSMSQFNGSGNGSNPNTNTNSNNTPLQSQLNLNNLTPANILNMSMNNDFQQQQQQQQQQQQPQPQYNMNMGMNNMNNGGKELDSLDLNNLELGGLNMDFL
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGVFSEDPNPNPNPIVIREVWASNLESEFELIRELIDRYPFISMDTEFPGVIFRPHVDPTKPFNHRNRPSDHYRLLKSNVDALNLIQVGLTLTDAAGNLPDLAGNRSIWEFNFRDFDVARDAYAPDSIDLLRRQGIDFARNTADGVDSTCFAELMMSSGLVCNDAVSWVTFHSAYDFGYLVKILTRRNLPTRLEEFLKTVKVFFGDNVYDVKHMMRFCDTLYGGLDRVARTLNVDRAVGKCHQAGSDSLLTWHAFQKIVDIYFVKEEHRKHAGVLFGL
The following text describes a protein:
Function:
Required for radiation resistance and meiotic viability and presumably acts in recombination and recombinational DNA repair pathways.
Miscellaneous:
MISCELLANEOUS: Present with 1050 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSLGIPLSQLIVESPKPLSSGITGLDEILNLGFQARSIYEIFGPPGIGKTNFGIQLVCNSLEGIQQSEINDDKILWIETFQEMPINILRERFQKFKIVEENVKRVRITKFGQLLYFFQNLFKLSQSVRYKLVIIDGFSQLVCDHLCTLSKRGGGMIDKTIHELKCRHLILIFTVMTKYTHSTGSTIIVLNDCMNTAFQSNEFESLEEYYEILDDGSNFFVNSNNERRKNNVHILKSALVANIAMGSKDSTWEVFLRDRIGLFRDWNEQVDETVFVKSKRVKASSSQSNEGCTTIKEMRINKRNFENLRIAIVFNLHGEDRKREGRNLKRSRSSDDRNYIVKFDFDKATGQLRDIIDLKPDTANIASFPTLSTSSSSCSQVFNNIDSNDNPLPNAEGKEEIIYDSEG
The following text describes a protein:
Function:
Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane.
Sequence:
MFSRLALRPLTVATSRSATTHSAQGLSRLPGHGSPGKVRPGFPSDNWVKGPMGVGLLAYICSGDCCAIKHEHSGLSLGIMEDGYYSSGITIGILTTFAVIRLLPAIVKWADSEIIKIESEYEKSRETKIKVLSISPSNGNKDPSKDNADQNV
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MEGGKKDNSRKISIFYLQKLMAMSSYMVNSKYVDPKFPPCEEYSQNNYIPEQGSDYYSQSQDTEFQHPGIYPRSNYTEQPFSCTTVPDPAVQPRAHVHDRANHPSHFAAQTDQGPPVQAAGPRTCGQQQSTKTQNGIQAKQPAVVYPWMKKVHVTTVNPDYTGSEPKRSRTAYTRQQVLELEKEFHFNRSTKAAEAGSSRGHISAARTDPSTPDPPDRQHFLSQALLALVWKTVVLLKNLKPIQSKESLNSTFYTCLSCIYIRRNPRGGSVCAFVSSCQMNSCFVLYICTVFYLVWCFEMCKVYWKNKDF
The following text describes a protein:
Function:
May participate in the regulation of cell proliferation through the E2F/RB pathway (By similarity). May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MFARGLKRKYGDQEEGVEGFGTVPSYSLQRQSLLDMSLVKLQLCHMLVEPNLCRSVLIANTVRQIQEEMSQDGVWHGMAPQNVDRAPVERLVSTEILCRTVRGAEEEHPAPELEDAPLQNSVSELPIVGSAPGQRNPQSSLWEMDSPQENRGSFQKSLDQIFETLENKNSSSVEELFSDVDSSYYDLDTVLTGMMSGTKSSLCNGLEGFAAATPPPSSTCKSDLAELDHVVEILVET
The following text describes a protein:
Function:
Gustatory receptor required for response to the bitter in taste neurons. Gr66a cells respond to bitter compounds such as caffeine, theophylline, threonine or valine. Flies avoid bitter substances, suggesting that Gr66a neuron activity is sufficient to mediate avoidance behavior. Required for sensing and avoiding N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide, as well as to L-canavanine, a plant-derived insecticide. Gr66a neurons are also involved in the sex-specific perception of molecules inducing male avoidance behavior, probably through sensing 7-tricosene (7-T), a male cuticular pheromone and leading to inhibition of male-male courtship. Finally, also plays a role in oviposition behavior, in which females evaluate their environment and choose to lay eggs on substrates they may find aversive in other contexts.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAQAEDAVQPLLQQFQQLFFISKIAGILPQDLEKFRSRNLLEKSRNGMIYMLSTLILYVVLYNILIYSFGEEDRSLKASQSTLTFVIGLFLTYIGLIMMVSDQLTALRNQGRIGELYERIRLVDERLYKEGCVMDNSTIGRRIRIMLIMTVIFELSILVSTYVKLVDYSQWMSLLWIVSAIPTFINTLDKIWFAVSLYALKERFEAINATLEELVDTHEKHKLWLRGNQEVPPPLDSSQPPQYDSNLEYLYKELGGMDIGSIGKSSVSGSGKNKVAPVAHSMNSFGEAIDAASRKPPPPPLATNMVHESELGNAAKVEEKLNNLCQVHDEICEIGKALNELWSYPILSLMAYGFLIFTAQLYFLYCATQYQSIPSLFRSAKNPFITVIVLSYTSGKCVYLIYLSWKTSQASKRTGISLHKCGVVADDNLLYEIVNHLSLKLLNHSVDFSACGFFTLDMETLYGVSGGITSYLIILIQFNLAAQQAKEAIQTFNSLNDTAGLVGAATDMDNISSTLRDFVTTTMTPAV
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Sequence:
MSSAHRPTWTPAMGKDARMNTKQYSSRDIAAHTKLKYRQPGQNSKDDLARRDLKLELEMAERESAAKRRRAAGLLPINEENQANEKQSSTKLLEDGTDEESKAKRRKILEEALLADKDDSESDEDSDDDKRGSKRHGKGKATSVPLSSHNGSDNGRTNGKNDDEESDDDDDDDDDSDDDESETAELLRELEKIKRERAEEKERQERESNANAALDKEAEAAVGNPLLNLKAALNQNGLSPTNSVSTSSNSFFVKRRWDDDVIFKNQARDVNEKPKKEFVNDLLRTEFHRRFLKKFIA