The following text describes a protein:
Function:
Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.
Subcellular Localization:
Nucleus.
Sequence:
MDEQKPPSEDKDAPADAAASSEEMGSAEGDPLKPPEGATAGPELESTDTKGAGGASSTPARRCALCNCGDWSLHGQRELQRFEPAPDWLEGLRGQQPPEGPGEAPPELGPVGDELAQIGFSERVAAVQLFEPTGHCWVHSCCAAWSAGVEQDTAGLTGVGRAVFSGISQKCEHCQRLGATIPCRAAACPHFYHFPCAAASGSFQSMKTLRLLCPEHLGEAVQMEDARCVVCDGPGDLRDLLFCTSCGQHYHGTCLDIALTPRKRSGWQCPECKVCQTCRQPGEDSMMLVCEACDKGYHTFCMEPAIEGVPADSWKCKNCRVCSDCGRRPSELDPGCQWHQSFSVCQGCQQQREAKEANGAQERAPQLEPPAQTLTSPERGEPAEMPVPALEPEPAGCNEELQHGGDPKETPPAHEKSPPSKVPPEEPPLEKLLPDELPTTTQPPDEPPPHVLHHNDPPPDELPLESAPLDEMAPSETPLDGPSLDELPPDQPPLSKSPPSEVPLEKLPPDEPHLDKLPLEKPPPSKPPVSELTLDELPLDERPPDEPPVDEMPPEKPPLDEQHLEEQPPEKPPLDEQPPIELPSEKELLDEQPPKELHPEKPLLDELPLAEQPPDEPPPSEQHLDELPTNEAPLDELLPKELPVSELPPPEELCPEELLPCELPAEEDPKPPGLLPEVAAAEEAPELAPEVPPEEEMELEPEPLLPPEMALPPPAPPDLCAVSPARPPDPLPHTTEDDVSEPPTPALPEPPRSPGTAMDTEPPGSPPPPLGSPACTPAPAEPPEDEEMETGGGEGDSSRSPPGDGPHASPPPELGPFQGLPEEEEEEEEEAPRLEREGTSGSSPPLSEEDGLEEGRAGGNPESKGSPLLLEPEELGLETPMEVCTAGEKLLERGDEGGPEPPTLRPRPDILNEISNLSQGDTSSSFPGSEPLLGSPDPEGGGSLSLELGPASGDASLQKEDAGSLPMGAETDDSLLFEPAAKGDADKGRRRSSPGRSRVKQGRSSSFPGRRRPRGGSHGTRGRGRARLKSTTSSVDTLALADVESSPSKEEDEDDDDTMQNTVVLFSNTDKFVLMQDMCVVCGSFGRGAEGHLLACSQCSQCYHPYCVNSKITKVMLLKGWRCVECIVCEVCGKASDPSRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVCCVQCGAASPGFHCEWQNNYTHCAPCASLVVCPFCREKYVEDDLLIQCRHCDRWLHAACDSLFTEEEVEQAADEGFDCSACQPYVIKPAAPAPAPDMLAKAKEPEPQYFRFEGVWLTETGMAVLRNLTMSPLHKRRQRKAPRLGALNGDGGLEGGDPLGPDDKKDGDLDADELLKAEVGVEHMECEIKLEAPASPDRDVGADVDSGKGLEDPDECKKRKRKPYRPGIGGFMVRQRKSHTRLKKVPAVLAEVGREGLSAEGHPEDGAPGDLPAEGGLDPSSAEGDEKKKRRARKKSKLEDMFPPYLQEAFFGKALMDLSRKALLAAGGVGDGAARPSLAQGAPRHKGDPNVAGALQGTPLERRETPTHPRGDDSTDGSATALDDDGKEDTKGEDLGTDDPKDSPNRGDAEKPATPGEGALSSDLDKIPTEELPKMESKDVQQLFKDVLGSAERGEQPLNCVEGSGAGQDPGRAQRPFLQGELQLSGQGSVSLGSLSGSVSLDSYSGVCQSPFLDNRERSGFFSPDHCEPESPWASSSAATTPSTPTTPTTEGEGDGLSYNQRSLQRWEKDEELGELSTISPVLYANMNFPNLKQDYPDWSSRCKQIMKLWRKVPAADKAPYLQKAKDNRAAHRINKVQKQAESQINKQTKGEGLRKPERPSLHLRIPVPPGTQPIYISSPPAAGEGFLKPGAGGGGPESPSELFLKLPPQSPAQVPSHDPYGAAPAYTLEPRFSSPLGQSPTSGAAFQPFPSQPLAGPRSIPGSQSSDFHPTPPGTPRHQPGTPDPFLKPRCPSLDNLSVPGSPGARPSEALLSPLPFGEQKKGLEVKKEEGGSLGVCSPSYTPTMGYGDSPGGPHLSTAELKAADVFKAPMTPRVSQVEPQSPGLGHRPPDPHPLAPSPPGHPDLYRQSPYPDPYAQPPLTPRPQPPPDACCSLPPRSLPSEPFSRVPASPQSQSSSQSPLTPRPLSNEAFCQSPVTPRFQSPDPYSQPPSRPQSRDPFTPLHKPPRPQIPEPGFKPGPLSHSPAATGGFGGTLAGEPHSKAPGGQQPPFTRSPGASVFPGSQPQPPMRFTFPPSVSEPLKGSPSHQPHGINSHFVPGKPQSSAYTSSPAFHQASSPLGTGASDPSYSLSPLRPPSVLPQQPPGAPQQPDASIAFLPRTAVGADKREETAAGLSAPPNRDLAELPGGQDGAVGTMSQSELEKQRQRQRLRELLIRQQIQRNSLRQEKESAAAAATPSPSGWAPEPSSQPYELSRSMATYQAPQDKSLLGTLATAASSGKLPGSVMVQTAAFVQDERLSRPPPAATPAAMDINGRAAVGPPQAFYPRGVFPALSPQQHLWQQQQAALRLPVASRFAPPAASTPVGSLGTRLPAPAEPVPASPGTLGAPFIELRHNMQKGPGGIVGSPFTPQPPRPRFFLPGEESTPQPLCAPVVPMQALPTPALQPQKMPVVPLPPASPQGTEMSNSHHQLHAKAVPPAPLPTPGLDLQHVPPRPLSSGSALRPDGTKDGAAPAPAPGKSHLSLEGGRLPCEVPVEPDLDDDFGSHKDLEDDDDLANLSLDPDVAKGDDDLGNLDSLETADPHLDDLLNGDEFDLLAYTDPELDTGDKKDIFNEHLRLVESANEKAEREAQLKTEPSGPSLKLPDPGDGKDAAPTGEDRDVPKEGLVPSAALPPDPSFKAQTLEVKAAALPTDVKPKLEDGCLKTSPCQFTAGSSERLPVKSEALQGTDKISASLGLSLKPSQTLLSPSAGPARLGLTHFPNSSSTLEKDPYVGAARGLPSAQLGSQSNPLLEKFELDSGALGLGGTRHSPADELDKMESSLVASELPLLIEDLLEHEKKELQKKQQMSAHLPRGTPQLPAPGHPMLHAATQPLDAQPPRLGTPQPPLQLGMVARPQLMPPQPPRLGNPQQGPALGPHMGMASGQPHVLAAPHGVQVALAQPQQSQQQVLVQKPMAGVQPPTMGLKPPQLVMQQQLANSFFPDTDLDKFAAEDIMDPIAKAKMVALKGIKKVMAQGSIGVAPGMNRQQVSLLAQRLSGGPAVSEMQNHMLAGSGQERSGTDPAQSRPNPPTFAQGVINEADQRQYEEWLFHTQQLLQMQLKVLEEQIGAHRKSRKALCAKQRTAKKAGREFPEADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNLMAEYRNKQQQHQHQASAVMALSPSQSPRLMSKLPGQLLSAHGIQQPAGTVVGAQGLGQQPGQPGGLRLPQGGVSMAVQQGLSFMGQQAVGNAPVPGTSNAFFSGNPALRGLSADSRLMQERQLQRMQLAQKLQQQQQQNMLGQVSLQQQQQQQQGVMGQVSMQQQGVMGQASMQQAGVMGQASMQQQGMMGQASMQQQGVMAQASMQQQQGIMGQASMQQQQGIIAQTMQQPGVMGQASMQQPGVMGQAAMQQPGVLAQSSMQQQGVMAQTSMQQPGMMAQTSMQQPGVMGQASMQQQGIMAQASMQQPGVMAQASMQQAGVMGQSSMQQQQGVMAQSSMQQPGVMGQGSMQPAAMVGQPSLLGQQQQPAATPQPGAVGQPMVPKQPGLMGSQQSLLVQQLSPQQQQQQQPGLLGHAPGLQHQAVLGHPTPQRQVLLAPHQQRVLGSPQTPGMLGHRLVLSQQLGQARALLAPQQQNSGAAAAQQGLLGMGQGQPPIQHFPQHGAMGQAPSVLHLSQGMQSAPAVLAAKEQPGGAEGGTLPAEGSESGGQLHGGEQQGPPNPAGLGEPQAPKHQAELGQGQQLLLGSPQPGVLGSVPTQPGLRAAAAPGTLLAPPQSPGATRPEPHGDTTGAAEPGKGLVGTPQGQQQPPRLQSPKAGPVAQPGSATTLSPGVLGQVPGPLMGQIRAQLQGVLAKNPQLRHLTPQQQQQLQALLVQRHQQSLLQQSQALRQPGPFPGQPPEHGPQARQPPRPLGPLFQAQAGVPAEEQGARGQPPAPQQPLAELVQAALAARGPQPGLVQLPTPPAPSSLGVGCAPQQLASPEQSPQEPKKMSPGVPASAPSPAEQGLAPDAARWDPEVPAADPADPGETHINGTEPPQVLVKQEPKEEAAAVVQCETDGDEAAKPEANGEPGAAQASSPLVPGGRSEAGHLLLQKLLRAKNVQLSAQCPGELNGHAENRGTGMEPRPQPVLLGREDPSIARKPVAAKPKRVQKGNERVPASRKKLRKDEGLRPGEALMKLKQELSLLPLTEPTITANFSLFAPFGSSPINGKSQLRGAFGSAVLDSVPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMVNGVTAAEEMGEQPKDADSTREPQKDTSAVEVKSLDLLAALPTPPHNQTEDVRMESDDDSDSPDSIVPASSPESVLGEELLRFPLLSEAKPELEERVLSPIIPIIPRASIPVFPDTKPFEATEPFGAAPPGKVGTAGPGAPWEKGKSSEVSVMLTVSAAAAKNLNGVMVAMAELLSVKIPSSYEVLFPDGPMRAAVVEAKKVETDMAGMLGGKEKVVLAGKVPESSSEWLKQFDAVLPGYSLKGELDLLTLLRQESPVPEKTLHHGYVNNVSNLDVRQLSVMPQEPSPPLSPSVPSPSSPTEAARVPDPEAAHEAPPAPSSPPPPAPSPAPREEGTAAPHSPPRFKPRSRPPEDGDEARPRLKKWKGVRWKRLRFLVTIQKGGAKRDGDKEIAEFIDKLGTTLRPEKVPRDLRKCCFCHEEGDGATDGPARLLNLDLDLWVHLNCALWSTEVYETQGGALINVEVALHRGLLTKCSLCQKTGATNSCNRIRCPSVYHFACAIRAKCMFFKDKTMLCPLHKLKGPCEQELSTFTVFRRVYIERDEVKQIASIIQRGERLHMFRVGGLVFHAIGQLLPHQMADFHSVTALYPVGYEATRIYWSLRTNNRRCCYRCTICENNGRPEFVVQVIEQGLEDLVFSDSSPQAVWNRIIEPVAMMRKEADMLRLFPEYLKGEELFGLTVHAVLRIAESLPGVESCQNYLFRYGRHPLMELPLMINPTGCARAEPKILTHYKRPHTLNSTSMSKAYQSTFTGETNTPYSKQFVHSKSSQYRRLKTEWKNNVYLARSRIQGLGLYAAKDIEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNEHVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQHKIPCHCGAWNCRKWMN