lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine. Modulates locomotion towards the drug nicotine.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MLPNIILILLIRYCSCGAGSRVYEKYGKQVQLSPATTSSYREWYDSNREHSTRNNTNVDDFQTQLKKSLENTTAAYNATFMQELIEERQRYLEKLNEGQFINDQRRLVEELLDPNYYEKTVHPKRDYTRPTRVNLSMSLYQILDVDEHMQSIEVNVWMVQHWYDEFLDWNPVDYGMINRTIVPYHQIWIPDTYLYNSEELEQKKTESLMNAQLETGHWNQKKDGAKVQLMFPAIYKLSCRMDVRWFPYDRQNCTFIISSWTHDKQTIDYWPLSSTVNLGNMARNDEWEVISFEFVRVEETFKCCTAPWVMLYAHLVIRRKPLYYMINLVVPTSIITIVAVTGFFTPTSSSSERDEKLYLGINTLLTMSVMMLMVCNQMPSTSTYVPLMSWYYIGIIMVIVVGTFLATGVLAIHGQKHYNKPISDRIRKLIYNPVVEFFILSPPTSLIDLWTEFGVISEQRHSTHLDPLLLQHMDPISHTTRADPQHFFGSISSQMCDLQSTYSYTARLATITRQYTQHAKMKALRKNQYRMSMDTSQARGVKKQKMQRRCSLEWEFLANVLDRILLTIFCGFTFAVFIILIGFDSFFTFHTDSPPKTM
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEKSRESEFLFCNLCGTMLVLKSTKYAECPHCKTTRNAKDIIDKEIAYTVSAEDIRRELGISLFGEKTQAEAELPKIKKACEKCQHPELVYTTRQTRSADEGQTTYYTCPNCAHRFTEG
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MVGAVTLLGLVLGDELSQGLLALDPIRVMYGLELWRPFTAACFLGPPSIGWLMNAYYLFEYGSSLERAFGTSQHMLFLLLQIGFLSVFSAFFGQPFFAQSVITSMLHVLSRSMPNQQVKWLIFTVPYWTLPYGLMASDVLQAGNAAAALPHVLGILSGHLYYFHKNVWPKIGGEDWLVPPMFLQRKLDGLEESKAKDSISTALKMRKKGKGKKLGSS
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of phosphorylated 5-6 carbon sugars and monophosphate nucleotides (NMP) in vitro (By similarity). To a lesser extent, dephosphorylates flavin mononucleotide (FMN) in vitro.
Sequence:
MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRAHFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYEVFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQELFEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQALKRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHGVAHMMKHLL
The following text describes a protein:
Function:
Putative phospholipase.
Sequence:
MNQFTFIIFTSEFQEQFDSFYQNVVWFLVMNFRIHMVMFFEIKQGQISNKACDLWHCIILKKFPLKLKLKNQYRLILMKAIYLLALICLCLCDDVTLYSVDQRVGKYQISEGKSPVALAWGDVRWMGQIVHLDNLKTSYAAGYLEGSLTYEHIYNHFWSWYDFTFGKEQLSNELSQYLVEQYEYSRQLVKDNKSDEYYEALARILAQNDGLFQAIQDKAPVNKRLTWVQLLLLQACGDIYELKEAMKPKAERIQWHLLTPEEFEWEREKRISCSSLIKALDDWSDVWMAHTTWTSYQNMLRIYKYYQFSGPNPYRVSFSSKPGLLYSKDDFYVLPDANMVVIETTNSILDSTLYDLIVPTTLLTWQRVPIAHAISNGGEKWTSTFIKHNSGTYNNQYIVIDLKVVKKNTPPAKDFIWISETVPGFAVAEDVTAKVISNGNYWKSYNIPFTTEVYDRAGYTEAVKKDPIKYSYEQCPRGQMMNRDAPKVKSLDDMKRFIRYNDYKNDAISGNNPGNAISSRLDLLETNPKAHGSIDGKIASLASVPQNIAYIQSGPTTDQQPVFSWTPAFTGIHWGQPTTFNFPWVEVKEHKVI
The following text describes a protein:
Function:
Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.
Sequence:
MEYDTDTIYTKVQTFCQNMQTPRTLEELMKDIHCYDENLLQDCIKRLPSTNGIYNEEDLALFIDKLHQYNEIKDIGQILLGKLAEVEGVLVKDLYDRFGLDMED
The following text describes a protein:
Function:
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Sequence:
MVQDLEQKLWSIASGIPFSSDYFLQASPIRKLKKENLFSKVFETYFLELGSGWGEVAISMALQRPNTGFILMEKKFDRIRHTIREIEKHSLDNVKILCVNFNWFLEEVFEENLFSEILLNFPDPWPKKRHHKKRTVNSKFLESLKILLPEKGKFYFATDYGPYARKVIRLFRDSKAFSPEKVELKSERNEIPVSHFERKKREEGKRIYYIDRVLVQK
The following text describes a protein:
Function:
Isoform 1 inhibits p53-dependent transcriptional activation and may function as an oncoprotein. Isoform 2 acts as a negative growth regulator by cooperating with p53 in transcriptional activation of p53-responsive genes and may act as a tumor suppressor.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3; The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns(5)P).
Sequence:
MLSPANGEQIHLVNYVEDYLDSIESLPFDLQRNVSLMREIDAKYQEILKELDDYYEKFKRETDGTQKRRVLHCIQRALIRSQELGDEKIQIVSQMVELVENRSRQVDSHVELFEAHQDISDGTGGSGKAGQDKSKSEAITQADKPNNKRSRRQRNNENRENASNNHDHDDITSGTPKEKKAKTSKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQVSYGEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCPKCRGESEKTMDKALEKSKKERAYNR
The following text describes a protein:
Function:
Component of the TLR4 signaling complex. Mediates the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion and the inflammatory response (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MEGVGAVRFWLVVCGCLAFPPRAESVCPERCDCQHPQHLLCTNRGLRAVPKTSSLPSPQDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEIGRLSRGSFEGLESLVKLRLDGNVLGALPDAVFAPLGNLLYLHLEANRIRFLGKNAFTQLGKLRFLNLSANELQPSLRHAATFVPLRSLSTLILSANSLQHLGPRVFQHLPRLGLLSLSGNQLTHLAPEAFWGLEALRELRLEGNRLNQLPLTLLEPLHSLEALDLSGNELSALHPATFGHQGRLRELSLRDNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGNWHSQGRLLTVFVQCRHPPALRGKYLDYLDDQLLQNGSCVDPSPSPTAGSRQWPISTAPGEGMTPPAGLAQELPLQPQPQPQQRGRLLPGVAWAGAAKELVGNRSALRLNRRGPGLQHQSPSAAAASGSAPQSLDLHEKPERGRPTRANLPQTEPTPTSEPASGTPSARDSWQRAAKQRLASEQQGRAVQYDSGVGLPPLVSDPCDFNKFILCNLTVEAVSANSASVRWAVREHRSPRPQGGARFRLLFDRFGQQPKFQRFVYLPERSDSATLHELRGDTPYLVCVEGVLGGRVCPVAPRDHCAGLVTLPEAGGRGGVDYQLLTLVLLAINALLVLLALAAWGSRWLRRKLRARRKGGAPVHVRHMYSTRRPLRSMGTGVSADFSGFQSHRPRTTVCALSEADLIEFPCDRFMDSSGGGTGGSLRREDHLLQRFAD
The following text describes a protein:
Function:
Strongly basic protein that binds directly to retroviral RNA and may be involved in its packaging and in the reverse transcription process.
Subcellular Localization:
Virion.
Sequence:
MNTLNETAAADESLDTAFLSSPQCAAPQRFQKIKRKSRASPETERKKPKSTIGKQGENPSATEPRYGGNSNRFGLLAHLTADKQVGNEIGDLYDQPSTSHQAAIAAAKRDAASAGTTSSAKRAQSKPPPIVMEGVDDVYLMMQSIENIVDLEKIEARASMSGVLRLYAADANTFRTIVNWLEIEEYEFHCYQLKEDRPYRVCVKGLHHSTLHHQIKDELEKIGHKVLDIHTPLRRNEPGTSKASPVNMFFLNIAAAANNKEILAVKALCHMRVVIEPLRKRNAIVQCHRCQQIGHTAKYCRKAHICVKCAGEHPAKDCTRPRIELCTCYNCGGQHPANYKGCSKLQAFLQRSRPRSGVAGRTEVSDRPTPRGLAGGKEIPSSRGGISYADVARGSIHHKQPMSLTHQQQKQKQQPYDGSPSRQRSRSRTRASRGTLQRSTDASSSIEAILQTLNENINSLRSIQEKQMELMMMMMKQQQQQSHQQGQIINLLTALQARQAP
The following text describes a protein:
Function:
Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
Subcellular Localization:
Secreted, extracellular space, surface film.
Sequence:
MEKGEEMEVEMETVTKQKLMPEPPVDHLPPLPPAPGCCPCCDCCGCCDCCGCCESFPLPLPGLGGCCSGCGSCPGCCCCPCCGGGCCRLLCSLPKLLCRLPQLPSCPINIKRFLIILIVVVVVVVIIVAVLLMGLFVTQGHTQAVLQMTIEGHGGDDSWLNLPTDTEEVATFEVDDGNRGPAAITYDFGKLLIGYKPWHGAACFLTKMDKGNVQGLDAAYKEFQKEEGMNLTSLVDRSNLGTTLNILCSHVPVFWA
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
METWRGSVLVFLLLSLSLGVLAHGESGGRKHGYHSYSRSCPQAERIIRDTLSKHAGWDRTIPAGVLRLHFHDCFVDVSSFTRFKFWFSNFAGLQGCDGSILLDSTPTDGTKVEKLSLPNFMSARGFEMIEEAKQRLEAACPGVVSCADTLAIAARDSTVMLGGKYYQVPTGRYDGRVSSQERGNTLPSPFGDASALIQNFKERGLSVQDLVVLSGGHTLGTAGCATFSNRLDNFTKTGKPDPTINPRYLSHLRRQCPAPGSPNRVELDKGSEFVFDNSYYKNLARRNGVLTSDQVLNEDSRTSHYVKNFAHKQHDFLSQFAASMVKMGYIGWKNKHNGEIRRVCSMVNTH
The following text describes a protein:
Function:
Involved in chromosome segregation during meiosis and DNA damage repair.
Subcellular Localization:
Nucleus.
Sequence:
MATKDDYSEDLENDADLMTDFSDDEYGYRHEEGHNDEEAAPNIEEIREAAADLCNQIGEYDYGDEHDWDGEQYPRLKRWKHRPRALGSLRSLRKLWKMDDDDPTRKVARAFAENEVLQHTILPALLESAGQGKEGDAIALACTDLLTAMTWPFDGLEELREQEKQGHLDLAELSEITLLDEHLVNYKSVILRNRSLDQQHDVLGVVMRYLLLPNLATKHHERSTLATGIISMCLHLFRNLLAIRDPVTTSLSSVERLSNANLQSELILSMHKHHILDALLMLSSSAETQAYNAWNAVASECIFHIFVGTMVKTIAEPTFSGSGTRMSHDSTPNASASNTAGSSSNANAGPISSLAESLAMETKLKRASASGKIATRHSRFGTTINFVGPDGELRVARNQAALIKPVAQLADEANQKGRRRAQRRKDAQEKGAPKLKSKWTPDAALVLQEWADTFVQSGFEPLAKSVLKDIRSERDKLGDLDVARVRIMQLGAFFLEYFLLRRTTAAKRRNAAKTAGSVQSTFAQRALDLQEPDEQHERSGQSAEQPEEAEEWPFELVSQWLEPWAFRMVLVRTIQSQETKAWLEFVASVRLWIVLLRLVDELANSKKESERDVAEGLQAEFYYMGETLEACHAIFRSYTTQSFAFLDAIIAFAYVMPKMLERYASNRDHMYVQAKKQVHRSRQDGDLDTDQDEARQIKEQLQETRSEREFRFADFQRKLATKQLAKACIVYLRRWKDNNGTEDQLNELVTVMHRIAIKANDYRQFFLATHRDYLRFMISGDTISAFEARAPTSAPNLRKLIDYILRKFSKLSPEEQSIYNAGKQPTRQPKPPRMPAEIVVRPGMTPDQEIGVAVGLLLKKEKMPAVLWIKSALEMASAMRTELVLRYEEEEAQRSIQGAGDDMMLLGELEKHNESPVERFQPYELAYHGNDELRTDASLMPELKLLCRLVGLEANDNELVNWRWSVPKEILPVHLDQKIETIERYIREPLDTHGRELTALVMRIRKPRVAGEADADVLDPADLPDGWNGAQSDSDEDGDYFDRIRASRSLVSADHVAAEGGLLRRSGPKKKLSHPTKGDGSRKKKQIQRIKQDIIDDSDDEFAFALADLQPQARTDADADSSSDDKEEEDDDDDNMDDQETPATSSVADLQEQFDQGKSNALDALRTAKQQRSNTEQPPLQDAGERINRRMDTKRLFLADSDEDDDDVLALSSQEPADISATSDRTATGPSVWAGIAKKRRLAILDDEDED
The following text describes a protein:
Function:
Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-decaprenyl)benzoic acid into 2-methoxy-6-(all-trans-decaprenyl)phenol during ubiquinone biosynthesis.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MATLLSPVLRRLRGLRRLPGLPRLAAEMPLRARSDGAVAGPLYSHHIPTSPLQKALLAAGSAAMALYDPYRHDMVAVLGETTGHRTLKVLRDRMRRDPEGAQILQERPRISTSTLDLGKLQSLPEGSLGREYLRFLDVNRVSPDTRAPTRFVDDEELAYVIQRYREVHDMLHTLLGMPTNILGEIVVKWFEAVQTGLPMCILGALFGPIQLSAQSLQVLVSELIPWAVQNGRRAPCVLNLYYERRWEQSLRALREELGITAPPVHIQGLA
The following text describes a protein:
Function:
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
Subcellular Localization:
Cytoplasm.
Domain:
IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
Sequence:
MPRQAPTRPRSPKKPRESDGGGGNVLQRIKLCVVLTFPSHSSGYHVSANSTAAFRAPAASPHFPTLEEQVLAFWDQHSIYEQSLARRANAPTFVFYEGPPTANGMPHPGHCLTRAIKDVFPRYKTMRGYRCERKAGWDTHGLPVEVEVGKELGIHSKEEIEAYGVEPFIQKCQSSVWRYMQEWQTLTRRLGFWVNLEEAYVTYHQSYVESVWWSLKNLFDRGLLYQGHKIVWWWAQGGTALSAGEVGQGYREVADPSVYVLFPLVDQPERSLVVWTTTPWTLPSNMYAAVKPELEYAVVKDSETGQELVLAAALVDSLAGKLKRELTVVDTISGESLVGQRYQPPFEDYQTRLNDPTGELVTGGKESLYWRVVAADFVTTDSGSGLVHLAPAFGEIDHEVLVTERTRFVDGQRPELLCAVGPDGKFTDEFASMKGVWVKEADKTLTRTLRESGRLLHLEQYLHDYPFCWRADDDPLIQYPRESWFIRTTKFRDLMLKNNSKIGWQPEHIRDGRFGNFLESNVDWALSRERYWGTPLPIWVCQSTGRMEAIESYEELLAKPGVDGTQVWDNAKAANPELPDDLRVHKPYIDSVTYDSPFESGARMQRVSEVIDCWYDSGAMPFAQWGWPHQNDAQFQEQFPADFISEAIDQTRGWFYSQLAISTMLFGEGASIREAGTKANELAPSRDSESDYPHPFRNCIVLGLMLSQWYESAGKEGQPKTVLLSESEAEQADGKFTKKTGKMSKSLRNYRSPSEIFDKYGADAMRWYFFANQAPWNSIIYADQAIRDSIPEFLLRLWNTYSFFSIYAEIDGFDPTSATDVDEQLSPESLASAPTYRPISERSEIDRWIHSELHRTLATVIDRMDAFDNYNACQAITNLLDGLSNWYVRRSRDRFWAPDSDSPDKHDAYWTLYEVMLELTKVIAPFVPFLADTLWQELTAPFGDKALKSVHLCDFPKPDASRVDQKLSDSMRLLREIASMGRSARADAKLKVRLPLAKVEVILTDDSAIDWLQSHDALVREELNVKAVDYTTDGGDYVQYTIVPNFKRLGPKVGKNIPVVKKMLGEADGNQLLTQLQTAGFVELELASGPLKLDGEDIEVRLQAREGWAAAQGSGCVVVLNTEVTPELRREGLAKDLIRGIQSQRKELDCQYTDRIRVAVETSDAELQSAIEEHRTMICGETLADDLVIGTLPNAQQVAIEGGELYVAKVSDK
The following text describes a protein:
Function:
After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MPAHSFAPSTDTTAFPSSIETSSTSGSLPFPLLSSLRHRPSGRIPKTAASPKSPTTSAMFSTRKYTPLPTSANGPARKRAGAGVTTWKRWALLVTIGVAVIFLVFNRASGGSDDQQIYNEDNTYTPSLDEDVVGGGDPIDYSSPPFRPEDSDVAQPLDHEGDGGDEGMDGSLDTLPVGDGGDDNDDNTSNPHDPTSSEAQDASEAEADFSESASEVESPFPGSFEQDPDPASTTACTEPVSSDKPLVQYALTIDAGSTGSRIHVYKFNNCGPSPQLEYETFMAVKPGLSAYARDPTAAAASLDPLLEEAYRVVPESLRKCTPVEVKATAGLRLLGQQESVAILDEVRNRLETNWDFTVGGEKAVEIMDGKDEGVYAWITANYLLNKIGEGAESDDTLAVMDLGGASTQIVFEPKFAADSEQALAEGEHKYELTFGGKDFTLYQHSYLGYGLMRARRSVHNLVAFTWSFGQGEVEWENLSEEVEVPNPCLSKGTTRRVALDPPGRQTVNVTMHGGNGNFEACNRVVELVMAKDAICEVKPCSFNGVYQPSLLDTFPRGQLLALSYFTDRIKPLLPSSTTSTLSISELTSMAKDVCAGPEVWAERWGSDAAAMEELAGRPEYCLDLTFMNALLGLGYELSPERELMVEKQLRGVELGWALGAGLALVEKAELTCTA
The following text describes a protein:
Function:
Required for normal Golgi function.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MALPPSSPSPSSPSLQRLSTFKNPPPSSLSSGAPPPQTPSSSSSSPLDSFATDPILSPFLSSSFSSASFSSAALASGSPASTAERLHQAIRLLDSQLRNDVISRHPELLAQLSSLSHADVSLSSLRSSVSSLQSSIRRVRSDLSEPIKSIRSKSVQLSNLHTATELLSHSVRTLRLSKKLRDLADFPDPDKIDLTKAAQFHFEILTMCKEYDLFGIDVIDEEIKFVTEIGEKLRSEAMKVLERGMEGLNQAEVGTGLQVFYNLGELKSTVDQLVNKYKGMAVKSVSVAMDMKAITSGSGGGFGPGGIRSSGSPHIGGGAKVREALWQRMASCMEQLCSLVVAVWHLQRVLSKKRDPFTHVLLLDEVIKEGDSMLTDRVWDALVKAFTSQMKSAYTASSFVKEIFTMGYPKLVSMIENLLERISRDTDVKGVLPAINLERKEQMVACIAIFQTAFLSLCFGRLSDLVNSIFPMSSRGSLPSKEQISQVLSHIQDEIEAVHPDARLTLLVLREIGKALSNLAQRAECQISTGPETRQISGPATSTQIRNFTLCQHLQGIHTHISSMVADLPSIATDVLSPYLAAIYDAACEPVTPLFKAMRDKLESCILQIHDQNFGADDADMDNNASSYMEELQRSILHFRKEFLSRLLPSAANANTAGTESICTRLTRQMASRVLIFYIRHASLVRPLSEWGKLRMAKDMAELELAVGQNLFPVEQLGAPYRALRAFRPLVFLETSQMGSSPLINDLPPSIVLHHLYTRGPDELESPMQKNRLSPKQYSLWLDNQREDQIWKGIKATLDDYAVKIRSRGDKEFSPVYPLMLQIGSSLTQENL
The following text describes a protein:
Function:
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling; Specifically binds poly-ADP-ribose and plays a key role in NAD(+) metabolism. Able to bind to the ends of poly-ADP-ribose chains created by PARP1 and cap them. This prevents PARP1 from further addition of ADP-ribose and thus limits the consumption of nuclear NAD(+), allowing the cell to maintain proper NAD(+) levels in both the nucleus and the mitochondria to promote proper mitochondrial respiration.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
The macro domain specifically binds poly-ADP-ribose. Binds poly-ADP-ribose with much higher affinity compared to vertebrate macroH2A1.1 orthologs.
Sequence:
MAKSKKIVAATSGSRSRSSRAGLAFPVGRVHRLLRKGHFADRIGSGSAVYLAAVLEYLTAEILELAGNAARDNRKTRINPRHIQLAVRNDEELSKLFTGVVIPSGGTLPHIWPALIPNEAKDSSTASASFNAPAKSATVKALAAAKSAGKKPAAVSSSSAAASSSSSASSSSSVAPKKPVRGFTILSKKTLHLGQTLYVVNGDLTEVRCDAVVHPTNGTMSFAGQVGGAIRAAAGAGVDAEVNSYMSEHSQLQVTKAAITSGHNLPSKWIVHVHSPNYSNAATATDALTQTIRNALTLADTKSIKTIAFPSIGSGNNHFPKHIAAQTILQAISAYFMSIMSSSIKEVYFVLFDQESINVYNAELINTN
The following text describes a protein:
Function:
Component of the branched-chain alpha-ketoacid dehydrogenase (BCKADH) complex, that catalyzes the overall conversion of branched-chain alpha-ketoacids to acyl-CoA and CO(2).
Sequence:
MGEGSRRPSGMLMSVDLEPVQLVGPDGTPTAERRYHRDLPEETLRWLYEMMVVTRELDTEFVNLQRQGELALYTPCRGQEAAQVGAAACLRKTDWLFPQYRELGVYLVRGIPPGHVGVAWRGTWHGGLQFTTKCCAPMSVPIGTQTLHAVGAAMAAQRLDEDSVTVAFLGDGATSEGDVHEALNFAAVFTTPCVFYVQNNQWAISMPVSRQTAAPSIAHKAIGYGMPGIRVDGNDVLACYAVMAEAAARARAGDGPTLIEAVTYRLGPHTTADDPTRYRSQEEVDRWATLDPIPRYRTYLQDQGLWSQRLEEQVTARAKHVRSELRDAVFDAPDFDVDEVFTTVYAEITPGLQAQREQLRAELARTD
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Subcellular Localization:
Cytoplasm.
Sequence:
MPYEPPTHTVERSLRATTGAKIIAGVDEVGRGAWAGPVTVCAAITGLRRPPVGLTDSKLLTIKRRTELEVELRTWVTSYALGHASPEEIDAMGMTAALRLAAVRALGTLPVRPDAVILDGKHDYLGAPWRVRTVIKGDQSCIAVAAASVLAKVQRDKMMAELGVDHADFGFADNAGYPSPVHKAALEERGPTPHHRLSWAYLDALPQWRHLKKVRSWVEGSVPEIEGQLGFDF
The following text describes a protein:
Function:
Component of the cuticles, which contributes to the formation of extracellular envelopes protecting the organism from the environment (Probable). Plays a role in alae formation in dauer larvae.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted.
Domain:
The small repeats A-A-P-[AVI] are also present in many proteins constituting the protective envelope of other species.
Sequence:
MTWKPIICLAALVLSASAIPVDNNVEGEPEVECGPNSITVNFNTRNPFEGHVYVKGLYDQAGCRSDEGGRQVAGIELPFDSCNTARTRSLNPKGVFVSTTVVISFHPQFVTKVDRAYRIQCFYMESDKTVSTQIEVSDLTTAFQTQVVPMPVCKYEILDGGPSGQPIQFATIGQQVYHKWTCDSETTDTFCAVVHSCTVDDGNGDTVQILNEEGCALDKFLLNNLEYPTDLMAGQEAHVYKYADRSQLFYQCQISITIKDPGSECARPTCSEPQGFGAVKQAGAGGAHAAAAPQAGVEEVQAAPVAAAAPVAAPVAAAAAAPAVPRATLAQLRLLRKKRSFGENEGILDVRVEINTLDIMEGASPSAPEAAALVSEESVRRRATSTGICLTPIGFASFLGIGTIVATALSATIFYVARPTSHKH
The following text describes a protein:
Function:
Metal transporter involved in the sequestration of aluminum into vacuoles, which is required for cellular detoxification of aluminum.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MGKNLRIKTGNRAPLLAQGETSRALSDLEEGSNVQPENVGFCRVIKLARHDAGKLVIATMALLVASLSNILVPKYGGKIIDIVSRDVRRPEDKAQALDDVTGTILYIVIIVVTGSVCTALRAWLFNSASERVVARLRKDLFSHLVNQEIAFFDVTRTGELLSRLSEDTQIIKNAATTNLSEALRNITTTSIGLGFMFATSWKLTLLALVIVPVISIAVRKFGRFLRELSHQTQAAAAVASSIAEESFGAIRTVRSFAQESHEVLRYGEKVDETLKLGLKQAKVVGMFSGGLNAASTLSVVIVVIYGANLTINGYMTTGSLTSFILYSLTVGSSVSALSGLYTTVMKASGASRRVFQLLDRVSSMANSGDRCPTNENDGEVELDDVWFAYPSRPSHMILKGITLKLTPGSKVALVGPSGGGKTTIANLIERFYDPLKGRILLNGVPLPEISHQFLHRKVSIVSQEPVLFNCSIEENIAYGLEGKASSADVENAAKMANAHNFICSFPDQYKTVVGERGIRLSGGQKQRVAIARALLMNPRVLLLDEATSALDAESEYLVQDAMDSLMKGRTVLVIAHRLSTVKSADTVAVISDGQIVESGTHDELLSRDGIYTALVKRQLQGPRFEGTSNATAEIEPISNGQ
The following text describes a protein:
Function:
Plays an essential role in tail assembly by capping the rapidly polymerizing tail once it has reached its requisite length.
Subcellular Localization:
Virion. Note=Component of the tail. Located between the last TTP-pb6 ring and the phage capsid connector.
Sequence:
MDHRTSIAQAMVDRISKQMDGSQPDEYFNNLYGNVSRQTYKFEEIREFPYVAVHIGTETGQYLPSGQQWMFLELPILVYDKEKTDIQEQLEKLVADIKTVIDTGGNLEYTVSKPNGSTFPCEATDMIITSVSTDEGLLAPYGLAEINVTVRYQPPRRSLRR
The following text describes a protein:
Function:
Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MEGLGGNVPSNQCRNFLSPSAFGAHHNSLSSGPAYTVGDRTHSVISESAKQCSPCPAPTSPPNPAISYGYHFGSSYYSCRNVGIQQTGLKSGAHASLAGYPVDKYMDVSSLTNTPVPTDEVSARAKEFAFYQSYPNPYQRVSGYLDVPVVPTISGHGEPRHEALISMEGYQPWTFANSWNGQVYCPKDQTQTPHFWKSPLSGDVMHNQTDINIYRRGRKKRVPYTKTQLKELEREYATNKFITKEKRRRISTATNLTERQVTIWFQNRRVKEKKVVSKVKENIP
The following text describes a protein:
Function:
Glutamate-adding enzyme which catalyzes the binding of the first glutamyl side chain to dihydropteroate. Leads to the de nove synthesis of tetrahydrofolate. de novo (By similarity).
Sequence:
MPIQLGLQRMLQLLKHLGNPQESFCAVQIAGTNGKGSICSYIYTSLLQAAIKTGRYTSPHFLEPRDTISINGQIASEEIFNTCWKQVIEVDRRFRTKATEFELLTATAFQCFHHSGVRVAVIETGMGGRLDATNVFEEPVLSIISRICLDHQAFLGNTLEAIAKEKAGIFKKNVPCVVDGLNEVNVLNQLKLSAEETRAHPFYLAKGKSGENKNEWIINTPNWGTNTFSTPLKGDYQGQNLACAVTALDILSSSFSIMLPHVQNGVKNTSWPGRLDIRSVPSLGDILFDGAHNKEAAIELAKFVNSQRREHNKSVSWVVAFTNTKDVTGIMKILLRKGDTVIATNFSSVSGMPWIKSMEPEVIKNSISSESSVECYTADNLTISEILRLAKEKNSSVIVCGSLYLLGDMYRYLKLDV
The following text describes a protein:
Function:
tRNA uridine(34) acetyltransferase, which mediates formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. The proposed mechanism is the following: (i) recruits S-adenosyl-L-methionine and cleaves it to generate a 5'-deoxyadenosine radical (5'-dA) in the radical S-adenosyl-L-methionine (rSAM) region, (ii) hydrolyzes acetyl-CoA in the N-acetyltransferase domain and (iii) an acetyl radical is formed by the products of the two domains and (iv) is transferred onto the C5 position of uridine(34) in the bound tRNA molecule. Does not show protein lysine acetyltransferase activity.
Sequence:
MGEMRDGEKFRRAVEEIARAVLAGEIKDRDELNRYKIIVSRKYHLSKIPGNSDILKAIPEEERDRFRELLKRKPTRTISGVAVVAMMTKPFPCPHGRCIYCPGGPSVGSPQSYTGKEPSALRAVQSAYHPYIIMMRRLKQLTDIGHDVDKVEVIIQGGTFPAVDLDYQEWYVKCAFKAMNDFPYFKDIENLEEKLVRLIVKGDKSVFEEDPEFKRAWELTHRKPYYYLEDEQRKNEKAKVRMVGLTIETRPDWAFERQIDRMLKLGTTRVELGVQTVFNFIHERTKRGHGVEEIIKATQLLRDAGLKINYHIMPGLPGSNFERDLYTFRKIFEDPRFRPDMLKIYPTLVTADAPLYAWYKAGKYRPYTTEEAVELLVEAYKLFPKWVRVMRIQRDIPAKLIVAGVKHSNLGQLVFNELIKRGIRPREIRFREVGHMMQKFGVQPEVEHIKLLREDYDAAGGREIFLSFEDVKNDILIGFIRLRIPSEKAHRKEINCCPSAIVRELHVYGPLVPIGGKPKYEWQHRGYGRELLAEAERIAREEFEVKKMLVISGVGVREYYRKFGYRKNGPYVAKRLDKDYAEYKKSKEFDAHLNT
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MDTESVQFLNNITSIETDNDVIEHLPQLITLACQKGQERQVIAQMQEMINESAIKVEQLCTDNNEAFNESVSSFHTVRDRVNQLQTSILELNNDIQASGRDLQDKKSQLKELHDAENNLNAYKENLVIYLDVFNHIEKAGSYFKEKRYYKALRLLDEISSTRLKRMSEYSLTKALVNSLSSSREYAKSLAMKDLHEWLFNIREKSVIIGSFAFEKMDERRRSWAREFAQDLQNINTRSPYSLHLALLNTVDFSPLNNEAIKITFEPLYTGIHIFSYLGILDEFQLSFEKDRRLQLESLAPKSLNQLDLKIVGNWLKAIAGFMIIEYYVLQRVPGFRTLDEVDFLWSSICDKLSDTLIPLLFQEQSTATIMKIKNLVMLLIHTMEFFNFPVWKLHGLCIKLIDAFGGALIYKHAGMFAETLDNDNYAPLEIKDEQMYCELIQPYWYDKKVDSFPVTMPFSKMCYECCQNADSFIRRFFMFLNDSITLAVEVNERAPRLFRRFIKFGFVNQLTDRLPRLGISQVAQVVQNFDAFEEPLLRMERILSSNKSITPMAQMLPENAQPSSHKATEMLEEISHGRKQALHQIFICINHKIDDFVDLAEYDWITTTPRTTVSGYLQEMLAYLQTMYMEILGGIDNSDKSYIYLETLDHLSTAIMKLITHPSVRRISSTAAAGFKLDIEFLESFAAKLPGQSIVNADSFIELRQSAKLLQAENVEEYMDADKFVRDFSRLDTSTAIKLLEKLLNNYSALPLSNDRPKRKAIEHVLAALRKRLAQEIAQAQAQGPQKSKA
The following text describes a protein:
Function:
Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
Subcellular Localization:
Cytoplasm.
Sequence:
MAEVSFGIELLPDDKPTKIAHLIKVAEDNGFEYAWICDHYNNYSYMGVLTLAAVITSKIKLGPGITNPYTRHPLITASNIATLDWISGGRAIIGMGPGDKATFDKMGLPFPCKIPIWNPEAEDEVGPATAIREVKEVIYQYLEGGPVEYEGKYVKTGTADVNARSIQGSDIPFYMGAQGPIMLKTAGEIADGVLVNASNPKDFEVAVPKIEEGAKEAGRSLDEIDVAAYTCFSIDKDEDKAIEATKIVVAFIVMGSPDVVLERHGIDTEKAEQIAEAIGKGDFGTAIGLVDEDMIEAFSIAGDPDTVVDKIEELLKAGVTQVVVGSPIGPDKEKAIELVGQEVIPHFKE
The following text describes a protein:
Function:
This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity); The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
Sequence:
MSKALLRFVRLSPTKARLIARQIQGMNAELAIASLEFTPNKAARVLSKVVASAVANGSLDAKSALIVSCRVDAGPVLRRSIPRAKGRATAIRKPTSHVFVEVAEGKEMKSSKSHKKNQAEGK
The following text describes a protein:
Function:
Forms part of the F-actin contractile ring during cytokinesis.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Domain:
The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
Sequence:
MDKLREKINAARAETDEAVARAEAAEAKLKEVELQLSLKEQEYESLSRKSEAAESQLEELEEETKQLRLKADNEDIQKTEAEQLSRKVELLEEELETNDKLLRETTEKMRQTDVKAEHFERRVQSLERERDDMEQKLEEMTDKYTKVKAELDEVHQALEDL