lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (By similarity).
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Cytoplasm. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasm. Also found associated with the plasma membrane.
Domain:
The Glu-rich region mediates histones interaction; The Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are required for the association with nuclear receptor ESR1.
Sequence:
MAAAVLSGASAGSPAGAPGGPGGLSAVGSGPRLRLLLLESISGLLQPRTASPVAPVHPPIQWAPHLPGLMCLLRLHGTAGGAQNLSALGALVNLSNAHLGSIKTRFEGLCLLSLLIGESPTELFQQHCVSWLRSIQQVLQSQDSPSTMELAVAVLRDLLRHASQLPTLFRDISTNHLPGLLTSLLGLRPECEQSALEGMKACVTYFPRACGSLKGKLASFFLSRLDSLNPQLQQLACECYSRLPSLGAGFSQGLKHTENWEQELHSLLTSLHSLLGSLFEETEPAPVQSEGPGIEMLLSHSEDGNTHVLLQLRQRFSGLARCLGLMLSSEFGAPVSVPVQEILDLICRILGISSKNINLLGDGPLRLLLLPSLHLEALDLLSALILACGSRLLRFGALISRLLPQVLNAWSTGRDTLAPGQERPYSTIRTKVYAILELWVQVCGASAGMLQGGASGEALLTHLLSDISPPADALKLCSTRGSSDGGLQSGKPSAPKKLKLDMGEALAPPSQRKGDRNANSDVCAAALRGLSRTILMCGPLIKEETHRRLHDLVLPLVMSVQQGEVLGSSPYNSSCCRLGLYRLLLALLLAPSPRCPPPLACALKAFSLGQWEDSLEVSSFCSEALVTCAALTHPRVPPLQSSGPACPTPAPVPPPEAPSSFRAPAFHPPGPMPSIGAVPSTGPLPSAGPIPTVGSMASTGQVPSRPGPPATANHLGLSVPGLVSVPPRLLPGPENHRAGSGEDPVLAPSGTPPPSIPPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPSLPPAPPSGTPPPAAPAGPPTASPPVPAKEDSEELPATPGPPPPPPPPPPPASGPVTLPPPQLVPEGTPGGGGPTAMEEDLTVININSSDEEEEEEEEEEEEDEDEEEEDFEEEEEDEEEYFEEEEEEEEFEEEFEEEEGELEEEEEEEEEELDEVEDVEFGSAGEVEEGGPPPPTLPPALPPSDSPKVQPEAEPEPGLLLEVEEPGPEEVPGPETAPTLAPEVLPSQEEGEQEVGSPAAGPPQELVEESSAPPALLEEGTEGGGDKVPPPPETPAEEMETEAEVPAPQEKEQDDTAAMLADFIDCPPDDEKPPPATEPDS
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MLKQATVLPFLVLLVVTPLAKGATWGYSGNNGPANWATVVANTSCGANSQSPINIVSASATQETFSAFSFTGYDAVPSDVNMTMSNNGHSVVVSLTPASTAISVSGGGLTGSYIAAQFHFHWGSQADLTVGSEHTLDGNSYPGELHIVHYSSAYGSLGDALASGSDTALAVLGFFLESSSSDNAALAPIISNIQNVNDSGDSYQFTTEFSLDSILPSSKTNFFRYSGSLTTPTCDEVVVWTVFQETIKISQSQLNTLVAGAYFTAESGQAAAVMENNYRPVLALNGRTVSSSFDASASLRILPAWQLLVAALTFAVAAALKA
The following text describes a protein:
Function:
Sterol O-acyltransferase that catalyzes the formation of stery esters.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGRTNTSDQLNAISDKNTKRKSLALDNEYHNNSSSEDDSSKIELSYTIPDNNNIISQETTTSVEDVLSVSSAPQNELRLRKQKSNNQDSPVDLNGVIVDVSKREKIFLKRKRQIDNKHGSDKSKYLSRFNDITFKAKSSTIFESDEFYKTDFFGMYVLFWLATAFAMVNNLIHTYFENSTPILQWTVVKVFKRDLFKVGLVDLAMYLSTYFAFFVQYACKNGYLSWKKVGWWLQAAFDGLFLFFWLWIASEYCLDFPWIAKVFLVLHSLVFIMKMHSYAFYNGYLWSIYKEGLYSEKYLDKLTNGKVTLPKGHTKNETEKVLQESIAFTKYELEYQSHATTENPDDHHVFDIDQTDKSIAKLQQEGLIKFPQNITLFNYFEYSMFPTLVYTLNFPRTKRIRWSYVFGKTFGIFGLIFLMILIAENNLYPIVLRCEIARKLPVSERIPQYFFLLMDMIPPFLMVYLFTFFLIWDAILNAIAELSKFADRDFYGPWWSCTDFSEFANQWNRCVHKFLLRHVYHSSISAFDVNKQSAAIITFLLSSLVHELVMYVIFGTLRGYLLLFQMSQIPLIIMSRSKFMKDKKVLGNIICWFGFISGPSIICTLYLVF
The following text describes a protein:
Function:
Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion. It is a highly efficient protease, at least toward amyloid-beta protein 40. Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently. It is also able to degrade amyloid-beta protein 42.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQVGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHARDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASRSRRPEHSGPPELFYDQNEARKYVRNSRMIDIQTKMTERALELLCLPEGQPSYLLDIGCGSGLSGDYISEEGHYWVGIDISPAMLDAALDRDTEGDLLLGDMGQGVPFRPGSFDGCISISAVQWLCNANKKSDIPARRLYCFFSSLYSALVSISSFLCMHACLSLITTQATRAGFTGGVVVDFPNSAKAKNLWAAPEHSLAIPTPQPTSLSLARAPHKKARRDLVKKSREWVLEKKERRRRQGKEVRPDTQYTGRKRKPRF
The following text describes a protein:
Function:
Regulator of the myosin I component of the cytoskeleton: required for regulation of cytokinesis, phagocytosis and pinocytosis.
Subcellular Localization:
Membrane. Cytoplasm, cytoskeleton. Note=Mainly cytosolic but enriched at the leading edge of migrating cells and at macropinocytic and phagocytic cups, possibly due to binding to acidic phospholipids.
Sequence:
MEQSKRVSMMREKFEAQSNEAESSPPPNRKPPPPNKRVQTNGTSSLNSSGSSFVSPSPSPSPSPQQPVKRPLPSPGVNKQAPPALPTQPRPQQQQPEIPVRPTTPTRTPPNLINSNGTSGGSGFSSSSGNSGYSSSNNNNSNSNSSINMNGNHSNGLNGGSSNPVPMRKVSSPINIANGTTPPPPPQPTPSQQPQQSPSSASHNNTQHNIPSPPPLPNNKPKKLAPTAVPAGLGSIIGGPKTPAISPGSTSPSLGSSNGNIPISTTSTPITPTPPISVPLATSPNNSHKDSISNSNSNNNNNNNNNNNNNSSNATTSPPSPPVSNVGNKQDEEKKGFLSIFTNKKKNKDKKKEFSVGSPFNVKHNIHVNYHSVTGFEGLPKEWEVILQSSGITREDVVEHSEVVIDVLDFHMQQQQQQAQQEQQALMQKQMQQSGIPAHMLNNPKPPTIPIRDANKQPHNQLQPTPHQPPQHHHQQQPPQQHHHQQQQQQHNNNNNNNNNNNNNNNNQQSAQQQSAGILSQQQEQQLEEMMCGGAYDDEQYDLNNQPLPDETNVSLYDLVSQEDPTKLFGEGSTKIGEGAAGEVFVVTQLKTNNKVAIKKMPLNQQNMKLIVTEIGIMKSCRHQNIIDYIDSYLVGDSLWVAMEFMGGGCLTEILEQFNSVKLVEAQIAYVCAETLKGLAYIHSQHRIHRDIKSDNILLGSDGSVKLADFGYAAQLTKSKQKRVTIVGTPYWMAPELIRGQNYDRKVDIWSLGIMAMEMAESEPPYMSFPPLRALFLITTKGIPDLKDQNKWSDDFKDFVKKCLDKDVENRPEAKVLLNHPFLKTACNSNGLVPAIMEAKKAKEAHSKFSIH
The following text describes a protein:
Function:
Associates with the actin cytoskeleton and may regulate actin polymerization in lamellipodia, through a rac1-dependent signaling pathway. May play a role in cell motility. Involved in cytokinesis by regulating the microtubule system and linking it to the cortical actin network.
Subcellular Localization:
Cytoplasm. Cytoplasm, cell cortex. Nucleus. Cell projection, lamellipodium. Cell projection, filopodium. Cytoplasm, cytoskeleton. Note=Weakly expressed in cytoplasm. Found in actin-rich protrusions, and lamellipodia and filopodia during motility.
Sequence:
MSASVKCGACAKTAYPLESVVANNNSYHKGCFKCSTCNSTLNVKTFKSFEGKLYCPVHTPKVSATAVTDSVALKNALNAPKKVAEGLGNAHRGLDEKPNIGLDSMATANALNAPKKVVEGLGNVQKGIGGKPTYAVFGADGQPTGEQQEQQQYTEEQYEQPQEEQQYQEEQQQYQEEEQQYQEEEQQYQEEEQQYEEEQ
The following text describes a protein:
Function:
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Sequence:
MQAEKLAYYPFISEASAHVGDLGISLESLLNSRAYRTARARGIERVKEALEGEIKKPPVSEEAQVLSELLSYPFARMLVACVDDQLFTRRYALAEAKAAYTFLRNETPDFLLEFGEDFGISAEIRDSHFSMHFTDYIRFSNSLKEPSWKLTNRQFRAGKIKITKEEFARLLEEAVRERIEQSFPIPEIPPEVSAFCAPYVAEIKEQFEVQKKKFGATDFGAVEPELFPPCISHALANVQGGVNLAHSMRFAMTSFLLNVGMSVEEILNLFNVSPDFDAEKTLYQIEHIAGATGNEYKPPACDTMRTYGNCIGKDGLCAKISHPLGYYERRIFLKNKEREKEEGKEKGNEEKKEKREEHEKKNEKGNEIKEK
The following text describes a protein:
Function:
Integral membrane subunit of the KtrAB potassium uptake transporter. The 2 major potassium transporter complexes KtrAB and KtrCD confer resistance to both suddenly imposed and prolonged osmotic stress.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKPLSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMILGKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSSGLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKNRRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTPRTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKKETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVGLTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG
The following text describes a protein:
Function:
Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MMAGGFLSLLAVSSTPPSARADINRVVYAVFAGAHARQPRQHHVVAWWFMPVNFGVAFLADGARSGEWPCSSSGHRHSSGGSSASCSAANFGNLLLVVIPAVCEQDGNPFGLAKKIPCVISYASFSMALGGVYIWTYTHSVMKRSGGEAYQPSPGCREQELVGEGERRHSPNDPGVNLASYHRRGHWLGNRNSAVAQLRSIFVGSNAPLRAVQDSLKLLGNHDIAPFLAWYCVLIEMIPVRCRDGTIPCLMLILGGNLTKVVAAIICVRYVILPLVGVAVVREARDMGFLPPDPLYQYTLMMHFAVPPAMSIASFLTNVYNLSQEQCLSCMMLGKRSARLFCCTWTYLVAALALTVWSTIFMWILQ
The following text describes a protein:
Function:
Possesses hydroxyproline O-galactosyltransferase activity. Transfers galactose from UDP-galactose to hydroxyproline residues in the arabinogalactan proteins (AGPs). Is specific for AGPs containing non-contiguous peptidyl hydroxyproline residues. The addition of galactose onto the peptidyl hydroxyproline residues in AGP core proteins represents the first committed step in arabinogalactan polysaccharide addition. AGP glycans play essential roles in both vegetative and reproductive plant growth.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MEGLPTTTKTERRSRSKNLHTSKPSLVMAFFSCVAWLYVAGRLWQDAENRKLLANLLKRNIEQKPKILTIEDKLMVLGCKDLERRIVEVEMDLTLAKSQGYLKHQLPQSESSSQRKLLAVIGVYTGFGSYLKRNTFRGSWMPRGDALKKLEERGVVIRFVIGRSANRGDSLDRHIEEENSKTKDFFILEGHEEAQEELPKKIKFFFSTAVQIWDAEFYIKVDDNIDVDLEGLIGLLEHRRHQDSAYIGCMKSGEVVSEEGKLWYEPEWWKFGDEKSYFRHASGSLIILSKNLAHYINTNSASLKTYAHDDISVGSWMMGVQAIYIDDNRLCCSSIRQDKVCSVA
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKAAAQSNSKNYVFLPFSKRVENLKIDVAHKIPRAADLEDEDVESYFISCLRKWEDLNLSTHYVNFLRSVTPYSQSLPQIVYHQKTIFDLIVQYAREGDSLSLQPILELLTQFARDLALEFASYIDQTLELLCILVQNNELEVVDWSFHAAAYLFKYLRKILAPRLIHTYDILSPLLGKEKQKSHVTRFTAEALSFLCKTVSYENAIEFTGHVLLDLNDHYTPQYHEGVVILFSRIIQGVDTSIHFKGKAFFEILLRSEIYTLPRSKSVIIPVLISTIHHCTSDSFNELEKLIISKITGEPLLYINLFKATLVTRKGSRVSDYPSFFKAYLQIPNLVSWENIESDLSVLIFEISALLFVYPQISDLMPHTVRIISFLQQGPLHLFFSFVDVVKQLNMQRYDSFIKPSLPKFISSLVSDESQKSLAILESVLDNSVPVPVDVASVSLNHFVYCIERLQIVSPSYEDIISLWSSLMIIISSSLGSDEIYKACLLFLRKLEDVSSESVLLGDICGIVLHLLQRKVSRLFLDSSYYKPILDSLLGVFGFLADSKVFLESIRPFFGTSYDFCSSYTSLMDRLINNLSRGLTSLRAASIDLIIALCKSLQKNEVLQSLSLVKKLSELPFDPSTSRDASVLLRNLSAKSSALEKDTRRVVLHALLGLTITRFTPLWPDLSRTAASIVTKEVEDEFLAIIYSWLSLPSPPSGLLGPTDTAVFVKPDLSLEKLPTLEINTFNCPAISYFETSFDECFSKFASSDNYIIGNLLKTNQEDLSNLPTFRSQALRVLNELPEIASRNINVLDNYLFSLQHGFDLNTEWARPDVYLLLGLYSKFTGIKEFVNRDARKEFFLWALTINDPKVQKLVLDIILLYSEEAITTYEENLRNLLDDKKCRDELITFLFVDYADSKIQDIHRPLLMPVVISILYGKMVSKGYGGQKNQAARRSTILSALGNMQVEDLQILVDIMLRPYNGLEVKLNANNNLEIDTGNIPSLTLRRQIGFLTMTEELLLQISSKLSSVAPKILNAVLYNLVVSDDQISSQEAFENFEVKMAYTVRQLSLKVFLLFLKSCSDVDFKPYNVFIYTAFVVPRLDRFADENTQSVSNLMKIFRCWFENEAYLDSVLEFSSHILTALLNTASHTAVKLPVLLYILDTLNLVITHLQSEESESQLREKILANLVMPNITLIFASLSNILKNPQFCNNNRVMDGSVQALSAVSEYMSLDIDSSPLLNLLVSFLRKPNRLVPSNVKSNILVLLCKLLPTNTKWLHASISQTNDFDTIMHLYTSMVDIKARQHLNDLLKIYSTIDDNLIFSSVFVEEINSISKKRLDEPDFERRLSAFTSFNEKHFSLISDLAWLPVLYNFFFYVQDAEELAIRASASLGIKRFIESITMNDASNQFKIDVFVKFIFPFIKNQMKNKNELIRQEFIGLLSYSIKSLTMVDAISDMQPLLYEGDEEANFFNNILHIQLHRRKRAMKRLVNVCAIGVIRSGNISQIFLPLLENFCLGNDTVQTLLDESVITIGEIIKWAHWNQYQAILKRYVSLLKNNAIDQKVVVRLITAVVSALRPLDDAVASYTNSEMNIEQFDGQKKKCVLASSLPSEERFTEVLTNDFFPTLMLYLHIRDESTVTLRVAIALSIVQLVALLPEEEIVLRLTPVLIDTCHILRSRSLESRDATRKALAAISKFLGPKYFSFIISQLQTSLKRGYQLHVLGYTVHYLLLAIEDVYPYGSIDYCMDSLAQIFVDEIFGEVGVEKDSEDYKSNVKEIKGNKSYDSYEIVARISSFDSLSTLLRPVKNVLFETNVPKSLRKVDELCRRLSLGIVANKQSASQSSLIFCYNVYEFVVKEKETVAALKQQENDGYRSAPNFFLENSKKLIRFTFDVLRGVSNKHKELLTARNMAAFVPLIGESLLSSSEEVQISALRFLVLLLPLKIDQVFSGSSVFTSQAVKYIQNSPSTNTELCQASFKFLASILPYENVKIKESTINYLLERVGTDIQEPDRQGVMFSLVRAVIARKIMTPELYKIIDLIRDMMVTNHTKSTRQTCRHLYYSFLLDYPQGKTRLSKQISFILKNLEYEFAPGRESVMELLHLILNNFSDALLKEYHQGIFIALVMVLANDSEPHCREMSAELIKLVYQRADNENFNLIRQLLSHWTSVEKAGKNLVRVSMQLFGLLFETFGFERMEEVHLFTKVFERVLSTTISHPEEATNEWELNYFGLQSWLKLVLADPKKSCEKEFSKIWESMRYLILFKHAWVRLSVSRLFGHFFAIIGDSNFGKLSLGIDGVVFSLDFVTQISNALQAQLRSPVLSEELGMQVAKNLIFLTRWFNSIRSSDDSPFLEIFRRMRKTLKKQTIEEYSINKKYLMQWFASVIHVFSGEELQPVLSEIIAALYRYTELQEAERKSQQELADLVTESLQVLQEKVGATVFARAYQEVRNAAIEVRRERREKRAIEQVVAPEVASRKKIRKNERKRENRKQKTNHHRMVNSIFKNR
The following text describes a protein:
Function:
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.
Subcellular Localization:
Secreted.
Sequence:
MPRGFTWLRYLGIFLGVALGNEPLEMWPLTQNEECTVTGFLRDKLQYRSRLQYMKHYFPINYKISVPYEGVFRIANVTRLQRAQVSERELRYLWVLVSLSATESVQDVLLEGHPSWKYLQEVETLLLNVQQGLTDVEVSPKVESVLSLLNAPGPNLKLVRPKALLDNCFRVMELLYCSCCKQSSVLNWQDCEVPSPQSCSPEPSLQYAATQLYPPPPWSPSSPPHSTGSVRPVRAQGEGLLP
The following text describes a protein:
Function:
Transcription factor that regulates expression of both nuclear and mitochondrial genes, and more specifically those required for glycerol-based growth and respiration.
Subcellular Localization:
Nucleus.
Sequence:
MEPFAFGRGAPALCILTAAARINLDNFVPCCWALFRLSFFFPLDPAYIRNENKETRTSWISIEFFFFVKHCLSQHTFFSKTLAPKRNFRAKKLKDIGDTRIDRADKDFLLVPEPSMFVNGNQSNFAKPAGQGILPIPKKSRIIKTDKPRPFLCPTCTRGFVRQEHLKRHQHSHTREKPYLCIFCGRCFARRDLVLRHQQKLHAALVGTGDPRRMTPAPNSTSSFASKRRHSVAADDPTDLHIIKIAGNKETILPTPKNLAGKTSEELKEAVVALAKSNNVELPVSAPVMNDKREKTPPSKAGSLGFREFKFSTKGVPVHSASSDAVIDRANTPSSMHKTKRHASFSASSAMTYMSSSNSPHHSITNFELVEDAPHQVGFSTPQMTAKQLMESVSELDLPPLTLDEPPQAIKFNLNLFNNDPSGQQQQQQQQQQNSTSSTIVNSNNGSTVATPGVYLLSSGPSLTDLLTMNSAHAGAGGYMSSHHSPFDLGCFSHDKPTVSEFNLPSSFPNTIPSNSTTASNSYSNLANQTYRQMSNEQPLMSLSPKNPPTTVSDSSSTINFNPGTNNLLEPSMEPNDKDSNIDPAAIDDKWLSEFINNSDPKSTFKINFNHFNDIGFIYSPPSSRSSIPNKSPPNHSATSLNHEKASLSPRLNLSLNGSTDLPSTPQNQLKEPSYSDPISHSSHKRRRDSVMMDYDLSNFFSSRQLDISKVLNGTEQNNSHVNDDVLTLSFPGETDSNATQKQLPVLTPSDLLSPFSVPSVSQVLFTNELRSMMLADNNIDSGAFPTTSQLNDYVTYYKEEFHPFFSFIHLPSIIPNMDSYPLLLSISMVGALYGFHSTHAKVLANAASTQIRKSLKVSEKNPETTELWVIQTLVLLTFYCIFNKNTAVIKGMHGQLTTIIRLLKASRLNLPLESLCQPPIESDHIMEYENSPHMFSKIREQYNAPNQMNKNYQYFVLAQSRIRTCHAVLLISNLFSSLVGADCCFHSVDLKCGVPCYKEELYQCRNSDEWSDLLCQYKITLDSKFSLIELSNGNEAYENCLRFLSTGDSFFYGNARVSLSTCLSLLISIHEKILIERNNARISNNNTNSNNIELDDIEWKMTSRQRIDTMLKYWENLYLKNGGILTPTENSMSTINANPAMRLIIPVYLFAKMRRCLDLAHVIEKIWLKDWSNMNKALEEVCYDMGSLREATEYALNMVDAWTSFFTYIKQGKRRIFNTPVFATTCMFTAVLVISEYMKCVEDWARGYNANNPNSALLDFSDRVLWLKAERILRRLQMNLIPKECDVLKSYTDFLRWQDKDALDLSALNEEQAQRAMDPNTDINETIQLIVAASLSSKCLYLGVQILGDAPIWPIILSFAHGLQSRAIYSVTKKRNTRI
The following text describes a protein:
Function:
Acts as a ribosome collision sensor, splitting the ribosome into its 2 subunits. Detects stalled/collided 70S ribosomes which it binds and splits by an ATP-hydrolysis driven conformational change. Acts upstream of the ribosome quality control system (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes and their subsequent degradation. Probably generates substrates for RQC; Endonuclease that is involved in the suppression of homologous recombination and thus may have a key role in the control of bacterial genetic diversity.
Sequence:
MLLADLGAETRGLLGWARLCAQLASFAQTKAAKGECETLLPFEARSEAERWLQRAEEALRLAESVPGGLAFDGVHDIASDVERAGRGGLLTGEALLAVASTLAAARRLRRAIEEHSGQAEELALLVAEVRTFPELEQEIYRCIDDTGEVADRASEKLRDLRSGHRRLRAEIQRTLLQLLQRRANCFQESLITQRGERFVVPVKVSHRDQVPGIVHDSSASGQTLFVEPMAVIDTTNRLVEGMRAEQVEIERILAELAALVAERATELLHLHRVLVDLDLAAARARYASWLGAVRPRFGERGCGLVQVRHPLLVWQERHEQGTPVVPVDLPVDPAVRAVVITGPNTGGKTVTLKTLGLVVLMAQAGLFVPARDPAVLPWFDRVLADIGDEQSIEQNLSTFSGHIRRIVRILAALTPDALVLLDEVGAGTDPQEGAALARALLVHLAERAGLVLATTHYGELKALKYTQSHFENASVEFDLATLSPTYRLLWGIPGRSNALTIAERLGLDAQVVAVAQASLSEGDVELDRVIGALQEQLQIQEEQVRSTTRLRGEVERLQSDLLRQQVLLDAREAALRARQDQQVREVVAEARAEVAQVIRTLQRGDATAQQAQQASEALKAVGEAYLGEESAAPAEYRPQPGDKVEIVPLGQMGEVLSPPDNGDQVRVQVGILKLTVPASQLRRPGSPATRPKPRPQAEVPRPPSPPKQEPLVRTEAQTIDLRGRRVAEAEALLEPELNRQSGPLWIIHGHGTGKLRDGIHEILERHPRVARFEFADRTEGGNGVTVVFLK
The following text describes a protein:
Function:
Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
Sequence:
MTTHEFFVDMTCEGCSGAVTRVLNKLDVKFDIDLPNKKVFIESDKNTDVLLETLKKTGKTVTYIGTK
The following text describes a protein:
Function:
Methyltransferase involved in the biosynthesis of methyl anthranilate in response to stresses. Utilizes anthranilic acid as substrate. Produces exclusively the O-methyl ester. Can also use benzoic acid as substrate. Low activity with salicylic acid.
Sequence:
MPMRIERDLHMATGNGETSYTKNSRIQEKVMFQIKPVLEEATRAAYSALLPQTMVVADLGCSSGPNTLRFVSEVIGIIARHCKEHDRRHDYPQLQFFLNDLPGNDFNNLFLLIQQFNKSMARNHKGEAAEALPPCYISGLPGSFYTRIFPSESVHLFHSLFSVHWHSQASEQLKDTKNKCLDIYITKNMPPSMVKLFQQQFEKDFSLFLKLRYEELVSGGQMVLTFIGRKHEDVFTGESNHLYGLLAQSLKSLVDEGLVEKEKLESFYLPIYSPSVGEVEAIVKQVGLFNMNHVKVFEINWDPYGDSEGDDVHDSIRSGENVAKCLRAVMEPLVASQFGEHILDKLFKEYARRVAKHLENEKTKHAILVLSIEKAIIHV
The following text describes a protein:
Function:
Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection.
Subcellular Localization:
Nucleus.
Sequence:
MSSSEIYRYYYKTSEDLQGFKTAAAEPYFNPMAAYNPGVTHYQFNGNTLASSSNYLSANGFISFEQASSDGWISSSPASHRSESPEYVDLNTMYNGGCNNMAQNQQYGMIMEQSVVSTAPAIPVASPPAVEVMGSSNVGTCKTIPASAGPKPKRSYTKKNQPSTTATSTPTAAAESSASVNLYTEEFQNFDFDNSALFDDSVEDDEDLMLFSGGEDFDGNDGSFDLADGENQDAAAGGSGKKRRGKQITPVVKRKRRLAANARERRRMQNLNQAFDRLRQYLPCLGNDRQLSKHETLQMAQTYISALGDLLR
The following text describes a protein:
Function:
(Microbial infection) Facilitates the development of the powdery mildew fungus E.cruciferarum; (Microbial infection) May prevent cell death upon A.alternata f.sp. lycopersici (AAL) toxin treatment.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAKSDIETGGGNELYPGMKESSELRWAFIRKLYSILSLQLLVTVGVSAVVYFVRPIPEFITETHRGLAVFFVILLLPLLLLWPLLAFEKKHPINCIVLSIFTLSISFSVGICCSLSQGRIVLEAAILTAVMVFGLTIYTFWAVKRGHDFSFLGPFLFGALLIILVFTLLQIFHPLGKLSSMIFSGIASIVFCGYIIFDTNQLIKKLNYDEYITAAIRLYLDVMNLFLSLLGIISN
The following text describes a protein:
Function:
Positive regulator for the plasmid-encoded virulence factors SpvA, SpvB, and SpvC.
Subcellular Localization:
Cytoplasm.
Sequence:
MDFLINKKLKIFITLMETGSFSIATSVLYITRTPLSRVISDLERELKQRLFIRKNGTLIPTEFAQTIYRKVKSHYIFLHALEQEIGPTGKTKQLEIIFDEIYPGSLKNLIISALTISGQKTNIMGRAVNSQIIEELCQTNNCIVISARNYFHRESLVCRTSVEGGVMLFIPKKFFLCGKPDINRLAGTPVLFHEGAKNFNLDTIYHFFEQTLGITNPAFSFDNVDLFSSLYRLQQGLAMLLIPVRVCRALGLSTDHALHIKGVALCTSLYYPTKKRETPDYRKAIKLIQQELKQSTF
The following text describes a protein:
Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.
Sequence:
MATTQQPPGRIDSLESLGSSTTNADLKPVKVESPNEQPPAKDEKLTTTTTSHDLNDMDTSRDAHGHLVSSDIVIDHNAVYQSNIFAPHAHSFFYGGYENLIGDWEDQSRYVNVEGVEFGLAGVYNENPSLVYHTGYGYSPYGPYSPGMTPLTSLSGDGQLYSPHQFQFPGAYYQQSAPPNMPYLSSSTPIPRVDLAVPIDQQGVFTSDTSNFNTQMFGPRPDLTRAPDGTGSVTPLSLPTVSVSPQPIGGLMPFGQGAMPITSGMGSQQQRSLYGFGSSISSIDRGYSHSGHYHNSTFETSIPSLGIKDQSSFVMDKNRRGGKESTLLCSCNGTVDFLNEQNRGPRANRSKIQMIECNSSLDTEKDSSTTGVDHKLYNSPDFVTEHKDAMFFIIKSYSEDNVHKSIKYGVWASTSSGNRKLDSAYHEAKQKEDPCPVFLFFSVNASAHFCGVSEMIGPVDFEKSVDYWQQDRWSGQFPVKWHMVKDVPNNLFRHIILENNENKPVTNSRDTQEVKLEKGLEMLGIFKKHEYEVSIIDDFEFYEEREKAMQERKARKHHQMYNSAGPVRAAFRNEQRNPPAISGDFINRLSKNFISAVRLEERNNADPATDKNSSLSVSVAPKPDELQKSETTPATSS