The following text describes a protein:
Function:
Force generating protein of eukaryotic cilia and flagella. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for assembly of the I1 inner arm complex and its targeting to the appropriate axoneme location. Also required for phototaxis.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MPLAPYSFETSRNGAAAIPHAVQNAHLPSDPYTDERILWLRSKVESGLMLEFDEFKNPPKLTSGSQRNKDIYPPCIPDMFKECLERQGRLNLQILLNYLEDTQESGDTALTFWVEIMTMRVEVPEDEPELTSSQQSITASTIRSSQVISGSHVLLDSNLPVIAATDELVTVNTDNAFVSDSAGTVLAHASDINPLQEDESASQEQQKGNADTFKDENTTSDSLSNRQDSSTIIKNTPNSIKRVPSVAIFETLRLHLATTHLPEKIAEINAIYFLRNSSGPISYPTSANDAANIMSHHLEIGYFSGHALLMLERVLQEIYLPMLSTTDFSDLHDETHDTHNTAMDRSRTDIGGAKFDDIKSELLVTMQKFTGQIAHTVQQVAGETRLKIPDTLAELNTMDVHQASTDPSILRTLESLAEEWAETVSGALAKEMKRVPVGNGPLAEIEFWRDRSASLSTLYEQLNLPIVHKIGHILNIAQVPCSSSLEFQLTELNKIYTEAKDSVKFLSTLERHFKNIVIGSLGSVQDSLPSLLNAIRMVWIISRHYNRDERMVPLMSRIAWEIANKVLNIVNVQTILREPPIEAKKKILDAKSLLESWSTTYFQVRERIEQSGRDQRWEFDRKKLFEQTNYMALRCGDLYEVAEVMEQFYSIFGPELKAVTGDPQAIDEVIKRVEALILPFEIVPFDIFNKRNQLAWEGVMARFREQIVQIEDMAKQFIDASFKKLRSAEGAFDLLQNIKNIKSRESINKQLMGKWYEILDQYTREVDIIDEIFKKHKDNPPCAKNQPRTAGAIAWSHSLFIRIKKTIVRFQSLQEMLTSEQGRAVTRKYLTVAKSMREYEESLYHQWCFSVEANSLQYLKNHILIKASSSTVATLDQNNGFFHTGTNTVGNTSNLPEKIIVNFRQELRDIIKETKYLDTMNFMVPESALNVTLQEEKYYSLVENLGSMLKAYHAAVDPLDVSELKLLHIHLTELKRVMKPGFTRLNWNSLGIPEFIQKCTLEINKFSSLVNQTRKNSLNINRTIDQIASALLIKEPRKDEIIDAHEFFDSVNTHRAHVMETLVVKYLGIGPLLMKTESLVANTNTGKSKILKDYYAYWEQKLFAAINFMVVNNLHYFESLLSPGGISKHGKGKLSVTSKYSKVTRELPLFRVTASLSVPEITISPMSQEIYKMMIKFVRSIVDSSKQFHRWLNGSCIIAPPQKIADEDSFIFSFHSDLVQNQSVIALVNSLNTTINKTFGSLHKWIDTWRKYRPLWKVDKLVTLEKFAQKKPSVVNYDDKLMFYAKLSKDVESQPSIKDIEFIRIISTPLQKAINRSHLNTICKDGLQLLQERFKSYDQDISRNPQTLDDLTFVLNVIANIRNASEEVELQYRDVMEAYRTLKMYHIDVDEEEFNASEELPRKWEEMLERAKQVDNALVPVKAKFTEQTHSQVRDFKQSLTRYKEDFIMNGPGAVNLDMDHGLKLLKESKEAVARFLGGRESLVRAEKLFNLTISSYPELYEVENQLKELDLIYTLYSDVKEAINSWSMTLWNNLDIGILNRGIENFSSRLKKLPKELKQLSPYNVVAEKIITFKESIPLFSDLKNEALRDRHWKKLMEITKRTFDMNPESFTLERLFAMNLHEHTEAIGEIVGGAMKELSIENAIKEVETTWRNLKFTVVKYMKGTEDRGYILGVIDEISTTLDDNAMSLQSMGASRFVTAFLPAVQQWEKVLSHIGEVTEIWMAVQRKWMYLESIFIGAGDIRMQLPEEAARFDRIDKAFKKLMSDTAKHNLVVEACNAEGRLELLQTLSDDLEGCQKSLSDYLESKRNAFPRFFFISDEELLSILGSHDPKNVQEHIIKMFDNVFKLNFGTDKHQKFIMGMSSSEGEVLNFRFPIPIDGRVEEWMTAVEGEMKRSNRTIHKEAIFNYANMERMQWLQTYQGMAGLASSQVWWTWEVEDVFSKIKSGNKLAMKKYSKILGDQLDILVVSVRSDLSSNDRKKINAQIIVDVHARDIVERFVRDSVMNKNEFEWESQLRFYWDRSTDELIVKQCNGVFDYGYEYMGLNGRLVITPLTDRCYLTLTQALSMKLGGSPAGPAGTGKTETVKDLAKALGILCMVTNCGEGMDYQAMGKIFAGLVQCGAWGCFDEFNRIELAVLSVISAQIKTIQNALVMNLKRFQFEGNEIALDRKTGIFITMNPGYAGRTELPDNLKALFRPVVMVIPDLELISEIMLFSEGFTLAKNLAKKMVVLYRLAKGQLSKQHHYDFGLRALKSVLVMAGSLKRGSPDLSEDVVLMRALRDMNLPKFVFEDVPLFLGLISDLFPGLDCPRVQYPNFNDAVEEVLKESQYIIVPEQVDKVIQLYETMLTRHTSMIVGPSGGGKTVVMETLAKAQTKLGISTKLYVLNAKAVTVAELYGVLDSVTRDWTDGLLSSIFREVNRPIGEKKERRFIVFDGDVDAVWVENMNSVMDDNRLLTLPNGERIRLQKHASLLFEVGDLQYASPATVSRCGMVYMDPKNLGYRPFYQKWINSRSNKAEQDTLLKLFSKYVPTLMECIIEGSFEGFMGEPLKRVIPVTPLTMVSQLCVLLETQLVADVKQSVQDAIVESIFIQSLVWSLGATVLVDDRLRFSDCLRKISELPLVNTNASIVLGQLPGNERLLHDYYFDLEENRWVPWTHYVPAYEHKRNLAFHEILVPTLDTVRHTWLLQKLVTHKKPVLFVGEVGTSKTVTVQNYLRQLPTDKTLLLNINFSSRTNSLDVQRNLEANVEKRTKDTYGPAAGKRLLVFIDDINMPSKDIYGTQQPIALLKLFLERGGLYDRGKELNWKYLKDVQLIGSMGTPGGGRSDIDPRFASLFAIFNITFPNDFSLLHIYSSIIEGHTTIFNDDIKQAVSKLTPMTLKLYSDVSKNLMPTPSKFHYIFNLRDISRIYEGMLMATSDFFDHGKQFCRMWCNEAMRVFYDRLVTDADRNYVSKLLNQLVFENFEADHEYITKSPILFGDFRHAMQEDVARLYEDLLDFTAVRSIFLEILEEYNETHNRMNLVLFEDALDHLTRIHRVIRMKRGHALLVGIGGSGKQSLTRLAAFAAGYGVFEITLSRGFGEFEFRENLKALYGLLGSGKKTVFMFTDAHVVQEGFLELINNMLTTGMVPALYSDDEKDAVVSSVGEEVARLGLLQTREVMWQYFVNKCSDNLHIVLCMSPQGNKLRERCRSFPGLVNNTMIDWFPPWPEQALFSVADAFLKDEFISAEIRPSIVAHVVGVHQSVSEYSAEFLLKYRRTNYVTPKNYLDYINTYNRLLEENRELNGRLCGRLESGLGKLEESSQQLDVLNKQLAEQNIAVRNKTEACSRLLEVITTNTKTAEEKKTLAEKKETELDAQTVQIVKDKEEAEVALAEALPALEEARLALANLSSSEITEIRSFAKPPKEVQKVCECICVIKGIKDVSWKSAKTMMSQTDFKSSLSLLDVDGISSNQIKLVKNILREMDVSVSRMLEISSAGAGLLKFVLAVVGYCNVAKQIAPKRAAVASLEKNLAFSKHEFDKITKELRRLSEELSALQIQFHTAKVEQLELKQMAEVMERRLLAADKLISGLGSERIRWARDLELLREQRIQLLGDCMVVSGFLSYTGAFNWELRNELIYKKWVQDLQSRNVPLSTEFRVEKILATEIEMSQWAQEGLPADELSIQNGILTTKASRFPLCIDPQQQALGWIKRREAGNNLKISTFNDPDFLKHLEMAITYGFPFLFEDVDEYIDPVIDNLLEKNIRTNGSRRFIVLGDKEVDYDPNFRLYLTSRLTNPTYTPKVFGSAMIINYSVTFKGLSDQLLIVVVAHERKELEEQRERLVTEMSQNKSLLKDLEDTLLRELASSTGLMLDNVELIQTLEETKSKATEIASKLVLANQTSTEVEASRDAYRLVAKCGAVLFFVLAELSTINPMYEYSLSAFLEVFMGSLHKSKPDPSLPKRLLKITDTLKYSVYNYACTGLFEKHKLMFSFQMTIKLMEADDLLDPVEINFFLKGDISLEQPIIKNPFSWTFDQGWKDLLKLSTLNSNFGMLPEHVRDNELVWKTWAKLDAPESEPLPMGYSERLTSFQKLCLLRCFRIDRVYNAITTFVIQNIGEKYVMPPVINYSNIFDQSTPTSPVIFILSPGADPQNDLQKLAETLGFGGNRLKFLSLGQGQAPIALQLLETAVTRGQWLMLQNCHLLVVWLRVLEKVLEKITKPHKDFRLWLTTEPTPAFPIGILQKSLKVVTEPPNGLKLNLRSSYYKLNEEMLADCYHESFRPLVYVLAFFHAVVQERGKYGKIGWNVKYDFNESDFRVSSTIMKTYLNKTAETKDGKIPWTTLRYLIGETIYGGRVTDDYDRRVLMTYLDEYLGDFLFDSFQPFYFFANSHVQYKVPMWGSRDDYMTYIDGLPLANAPDVFGLHSDAEIGYLTSAVKDMWSQLISLQPRTSDRAGGISREEFIASISSDIQNKLPTIFDTARIYKTIGTPSPTQVVLLQELERWNILVEHMSSSLKDLQRALKGEIGMSTKLDELSNSLFNGALPPMWRLLAPQTEKGLGSWMLHFERRYQQYSSWIKNGEPVVIWLSGLHVPEAYITALVQTTCRKNGWPLDRSTLYTQVTCHVDPKEITERPLSGCYVQGLYLEGAGWDTKSNSIVRLENGGRLIQDLPILRIIPIEAHRLKLVNTFRTPVYTTQQRRNASGVGWVFDADLSTNDHSSHWVLQGVCLLLNTD