lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
Domain:
Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
Sequence:
MINLFAIILPIDSTVRESKKFMHLCFKTQEYYFTEDAQKAEELARLTRISKHYLREFSLAGFCNVSKSIIFCFIGNVATYVIITLQFNEANIEKSKYVDKDRTGKAIRQKFLDYFINKNNHNFIKSSPVVPFCDPTVAFVNAGMNQFKGVFLGTHQPQYKNVANSQKCIRVGGKHNDLNVVGGDGYHHTFFEMLGNWSFGDYFKQEACELAWKLLTEEYKIHPSRLYVTYFKGDPVLGIDEDLETKEIWKTIGVSEDRILPFTSKDNFWEMGPTGPCGPCTEIHIDHTTSNNRAKLVNKGLHDLTELWNLVFIQYNRKSNESVDLLPEKHVDTGMGFERLTAVLQGKISNYDTDNFTYLLKAIHKNCSKIPEYRGTFGEKDWNSLDASYRVLADHARMVTVCLADAMIPEQNQKLRRVMRRAFLLCENVFNKDSGLLKELSNYVIEHLGCVYPEMERNVKQIHQIIDYEEEVYKSVRKQATEEWVKLAKHQPKLLSLDINENPSLVAGYKEISSTNPKFIDAQLAFKLYDTFGLDEDSISSLAQILNLPFNASDLHKQLELAKIRSKEQGLVSGPNVYEQLTRAKVPKTDRSTLYNYAKKGEKYVFDDLEVVILKIVKDSKLVRQIESENFYGLVLDKSSFYTEAGGQISDRGAINFGDCVFEVTEAQDCNGYILHKGFLRSGESGRVKVGMTGSLKIDPDFRLKNMRNHTAVHLLNSVLKKVKGATCQKSSKVTQNYFNLDVGIFAEKLSLDELELVESTITKVIQGRLPVNISELDSQRLANLDEIILIPGEVYPETGIRVVEVKGGEGFLSREPCCGTHVLNTSDIEDFCIVSMKSLGRSTTSIHGVTGDRAKVAKSNGTHLLTNLETLEKSVSDNIDKPDVLNMAITSFKKQLNYSVEDENILPVVVKQQCADILNKISKQIKDSGKRNLREFIEIEMRNAMESNVSQTAKNRKYMVHYLRTSLILENVSLQKATNLCPDIPVLIISYSDNVVKARCCVPENMKNVSFDAEKWMKETVAAVFKCSLVPPKGYDPSLVCNMKAKRVKLEDWDPLLQESLELAKKFAEQNL
The following text describes a protein:
Function:
Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Presynaptic cell membrane. Postsynaptic cell membrane. Note=Also expressed in neuronal cell bodies. Localized to excitatory, but not with inhibitory, synapses.
Sequence:
MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGASAPGSPEEAARGAGPRPNMFDVLTFPGTGKAPFGSPAADAPPPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGHSDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEKVLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV
The following text describes a protein:
Function:
Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit. May act redundantly with REI1 to directly promote a stabilizing structural rearrangement in cytoplasmic 60S subunit maturation independent on the REI1-specific ARX1 recycling.
Miscellaneous:
MISCELLANEOUS: Present with 2240 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSTFFTCNCCVIQFKTSDLQRYHMKTEWHRYNLKRRIANLPPIGAEQFAEKLQISEKEQAENQVDEFGFPVLKPVMNQSNALPQKQKKPIKSKRGRKVGTNLLKRKDRDIAKEKQNRSVSPSGSISSQLSNLTVGTENTNTDYGEDTVSEYGFTSDSNYEYATSDEELDIADKPSDKENEKITITECIYCGKDNKEVERNVKHMFSEHGLFIPERSYLIDLNGLLEFLIKMIVIDHNCLCCNFHGSGLESIRAHMASKRHCRLPYETKEERQLFAPFYDFTYDDHSISKNLQNDRAITSKLSSVYGAKNDEEDGEVDITLVSSENDINANYTTVSIDESGLELTLPTGARLGHRAGQRYYRQNLPSQPNPNESRRTITAADRRMVSGVTEKQYKKGMKKMQQLEKNAINTQIRREIKRVNFQTHYRDELLQ
The following text describes a protein:
Function:
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response; Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein; [Tumor necrosis factor ligand superfamily member 13b, soluble form]: Secreted.
Sequence:
MDESAKTLPPPCLCFCSEKGEDMKVGYDPITPQKEEGAWFGICRDGRLLAATLLLALLSSSFTAMSLYQLAALQADLMNLRMELQSYRGSATPAAAGAPELTAGVKLLTPAAPRPHNSSRGHRNRRAFQGPEETEQDVDLSAPPAPCLPGCRHSQHDDNGMNLRNIIQDCLQLIADSDTPTIRKGTYTFVPWLLSFKRGNALEEKENKIVVRQTGYFFIYSQVLYTDPIFAMGHVIQRKKVHVFGDELSLVTLFRCIQNMPKTLPNNSCYSAGIARLEEGDEIQLAIPRENAQISRNGDDTFFGALKLL
The following text describes a protein:
Function:
Required for pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MANATIRGAVSIHGTNPQFLIEKPVRARIYESPFWKEHCFALSAATILPLAVSLNHIGGLVGLQRPSHFLCLLQKLLQIQPEPAIINAYLEAREFKYLGALTAFYIRLTYTSKHVYTLLEPMLEDGRKLRWRSGDGAYEILHMDEWVDMLLREERVCDIILPRLTRRDVCETRDGLLPRISKLETSLLKALQAGERTDSSDDEHSDADEDGMLNLTRCKLERLKQATHTWRKSSPQPGYAYDVEAEYTSQEDSDGEASTRPRFISPSPSVSPDRQLQSRARDQAAYLSRSPSRSPDRQTYVSRSPSLSPDRQLSYVDGEERQEAYISRSPSRSPDRQLSDLSDVDGEERQEAYISRSPSRSPDRS
The following text describes a protein:
Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Transports lumefantrine, mefloquine, chloroquine, quinine, quinidine, amodiaquine, piperaquine, dihydroartemisinin and quinacrine.
Miscellaneous:
MISCELLANEOUS: Can transport human ABCB1 substrates rhodamine B and vinblastine. Does not transport amantadine.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MGKEQKEKKDGNLSIKEEVEKELNKKSTAELFRKIKNEKISFFLPFKCLPAQHRKLLFISFVCAVLSGGTLPFFISVFGVILKNMNLGDDINPIILSLVSIGLVQFILSMISSYCMDVITSKILKTLKLEYLRSVFYQDGQFHDNNPGSKLRSDLDFYLEQVSSGIGTKFITIFTYASSFLGLYIWSLIKNARLTLCITCVFPLIYVCGVICNKKVKLNKKTSLLYNNNTMSIIEEALMGIRTVASYCGEKTILNKFNLSETFYSKYILKANFVEALHIGLINGLILVSYAFGFWYGTRIIINSATNQYPNNDFNGASVISILLGVLISMFMLTIILPNITEYMKALEATNSLYEIINRKPLVENNDDGETLPNIKKIEFKNVRFHYDTRKDVEIYKDLSFTLKEGKTYAFVGESGCGKSTILKLIERLYDPTEGDIIVNDSHNLKDINLKWWRSKIGVVSQDPLLFSNSIKNNIKYSLYSLKDLEAMENYYEENTNDTYENKNFSLISNSMTSNELLEMKKEYQTIKDSDVVDVSKKVLIHDFVSSLPDKYDTLVGSNASKLSGGQKQRISIARAIMRNPKILILDEATSSLDNKSEYLVQKTINNLKGNENRITIIIAHRLSTIRYANTIFVLSNRERSDNNNNNNNDDNNNNNNNNNNKINNEGSYIIEQGTHDSLMKNKNGIYHLMINNQKISSNKSSNNGNDNGSDNKSSAYKDSDTGNDADNMNSLSIHENENISNNRNCKNTAENEKEEKVPFFKRMFRRKKKAPNNLRIIYKEIFSYKKDVTIIFFSILVAGGLYPVFALLYARYVSTLFDFANLEYNSNKYSIYILLIAIAMFISETLKNYYNNKIGEKVEKTMKRRLFENILYQEMSFFDQDKNTPGVLSAHINRDVHLLKTGLVNNIVIFSHFIMLFLVSMVMSFYFCPIVAAVLTFIYFINMRVFAVRARLTKSKEIEKKENMSSGVFAFSSDDEMFKDPSFLIQEAFYNMHTVINYGLEDYFCNLIEKAIDYKNKGQKRRIIVNAALWGFSQSAQLFINSFAYWFGSFLIKRGTILVDDFMKSLFTFIFTGSYAGKLMSLKGDSENAKLSFEKYYPLMIRKSNIDVRDDGGIRINKNLIKGKVDIKDVNFRYISRPNVPIYKNLSFTCDSKKTTAIVGETGSGKSTFMNLLLRFYDLKNDHIILKNDMTNFQDYQNNNNNSLVLKNVNEFSNQSGSAEDYTVFNNNGEILLDDINICDYNLRDLRNLFSIVSQEPMLFNMSIYENIKFGREDATLEDVKRVSKFAAIDEFIESLPNKYDTNVGPYGKSLSGGQKQRIAIARALLREPKILLLDEATSSLDSNSEKLIEKTIVDIKDKADKTIITIAHRIASIKRSDKIVVFNNPDRNGTFVQSHGTHDELLSAQDGIYKKYVKLAK
The following text describes a protein:
Function:
Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Required fo cell division in meristems. Involved in the maintenance of transcriptional epigenetic gene silencing (TGS) at specific loci (including some transposons) by regulating histone H3 acetylation, 'Lys-4' and 'Lys-9' methylation.
Subcellular Localization:
Nucleus.
Sequence:
MYGGEFDGNAAFAGGGFMPSQATTQAPESSSASRNRDARTLLPLTLKQLNSVSTNGESNFSIDGVDINTVAIVGRVSRIENRITQVDFVVDDGTGCVECIRWCHERQETEEMEAVRLGMYVRLHGHLKSFQGKRSMNVFSVRPITDFNEIVHHFTECMYVHMYNTKPRGGSITQATETPRPQPYSSMPTPARPFQTGPSNQFSNQFNDPMHGVRQTVLNYLNRPMHLRSEAGVHCDVIARELRIPLQQVKDALEQLSNDGCVYSTSDETCFKSTANA
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MATELKAASEEVKVDLFEDDDEFEEFEINEEWEVKEGKEITQQWEDDWDDDDVNDDFSLQLKRELENNAEKK
The following text describes a protein:
Function:
Probable methyltransferase.
Sequence:
MKSFIFRQNPRKQQQEQNNLVDYSDSDDDEECNDDIFVNNEIIINVSEKSSKDYGLFIWDGSLVLSWYLFTLTKNNPQFWNGKNVLELNAGVALPSILLSKLGVNKIIITDRIDGFIEIQNNIIDNLNLNGFNINNNNNINDNKIFIEPLSWGNFEKFSNQLTSSSIDYLITSDCFYDNTKNYDDIFATWYYFLLKNDKLVILLTYQVRCNEKTIFNYLKKWKLKSEILSIKDISIPNYNIDSEIILIKITKNQ
The following text describes a protein:
Function:
Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (By similarity). May be involved in Golgi homeostasis (By similarity).
Subcellular Localization:
Endosome. Lysosome. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle, COPI-coated vesicle. Endoplasmic reticulum.
Sequence:
MASRDLRAEVDFVLLQLLGDLEQLEAKRQALNARVEEGWLSLSKARYAMGAKSVGPLQYASHMEPQVRVGTSESQDGLQKFWMVRAGTQTPEEVGSREAALRRRKGLPRTPEPDSSPAPQNPLKWFGILVPHSLRQAQASFREGLQLAADMASLQSRITWGQSQLQELQEKLKQLEPRAP
The following text describes a protein:
Function:
Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms. Promotes the repair of DNA double-strand breaks through the homologous recombination pathway.
Subcellular Localization:
Chromosome. Cytoplasm.
Sequence:
MADTDLFMECEEEELEPWQKISDVIEDSVVEDYNSVDKTTPVSVSQQPVSAPVPIAAHASVAGHLSTSTTVSSSGAQNSDSTKKTLVTLIANNNAPGTQFVKPTVGVPQVFSQMTPVRPGSTMPVRPTTNTFTTVIPATLTIRSTVPQSQSQQTKSTPSTSTTPIATQPTALGQLAGQPPGQPNQTSNPKLAPSFPSPPAVSIASFVTVKRPGVTGENSNEVAKLVNTLNTIPSLGQSPGPVVVSNNSSAQRTSGPESSMKVTSSIPVFDLQDGGRKICPRCNAQFRVTEALRGHMCYCCPEMVEYQKKGKSLDAEPSVPSAAKPASPEKTAPVTSTPSSTPIPALSPPTKVPEPSESAGDTVQTKLIMLVDDFYYGRDGGKAAQLTSFPKVATSFRCPHCTKRLKNNIRFMNHMKHHVELDQQNGEVDGHTICQHCYRQFSTPFQLQCHLENVHSPYESTTKCKICEWAFESEPLFLQHMKDTHKPGEMPYVCQVCQYRSSLYSEVDVHFRMIHEDTRHLLCPYCLKVFKNGNAFQQHYMRHQKRNVYHCNKCRLQFLFAKDKIEHKLQHHKTFRKPKQLEGLKPGTKVTIRASRGQPRTVPVSSNDAPSGALQEAAPLTSADPLPVFLYPPVQRNVQKRAVRKMSVMGRQTCLECSFEIPDFPNHFPTYVHCSLCRYSTCCSRAYANHMINNHVPRKSPKYLALFKNFVSGIKLACTSCTFATSVGDAMAKHLVFNPSHRSSNILPRGLSWMSYSRLGQTPERVLDRSMKNTYLPPPLLPNKAATVKPVGATSAEPQELAGPVLQALPSPASTATPPATPTHPQPSALPPLATEGTECLNVNEQEEGSPVTQEPEPASGAGSGGSGVGKKEQLSVKKLRVVLFALCCNTEQAAEHFRNPQRRIRRWLRRFQASQGENLEGKYLSFEAEEKLAEWVLIQREQQLPVNEETLFQKATKIGRSLEGGFKISYEWAVRFMLRHHLTPHARRAVAHTLPKHVAENAGLFIEFVQRQIHNQDLPLSMIVAIDEISLFLDTEVLSSDDRKENALQTVGTGEPWCDVVLAILADGTVLPTLVFFRGQANRLANVPDSILLEAKDSGYSDDEIMELWSTRVWKKHTACQHSKSMLVMDCHRTHLSEEVLALLSASSTLPAVVPAGCSSKIQPLDVCIKRTVKNFLHKKWKEQAREMADAACDSDVLLQLVLVWLGEVLSVIGDSPDLVQRSFLVASVLPGPDGNVNSPTRNADMQEELIASLEEQLKLNGEQSEEHSASAPRPRSSPEETVEPESLHQLFEGESETESFYGFEEADLDLMEI
The following text describes a protein:
Function:
Necessary for the targeting of ARL3 to the Golgi. Involved in protein trafficking. May serve as a receptor for acetylated ARL3.
Miscellaneous:
MISCELLANEOUS: Present with 238 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MVSIRRYLRVPNELKPSQIFKQDSLSPSKIGLQIVLLQIFYYTTAIVLFYCWAKLAGYDLNIKEWLFSWENIDFTNAYGLSISLLWLLDSLICVFFLTVIVGRSKLAWDFAITIHAINFIVVFLYTRKFPSFSWFFLQILSSLILIFLGTWTTRWRELRDTFFEGLVDPNEGEVGLVTPSQQHSNHSELEQSPIQLKDLESQI
The following text describes a protein:
Function:
Transcription factor that specifically binds the purine-rich double-stranded telomeric repeated sequence 5'-AAACCCTAA-3' found in promoter telo boxes.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing donor splice site.
Subcellular Localization:
Nucleus.
Sequence:
MEANSGGGGGAEGGRAVTGGGGGGGGSDVELVSKTLQVEHKLFYFDLKENPRGRYLKISEKTSATRSTIIVPSSGISWFLDLFNYYVNSEEHELFSKELQLDSKVFYFDIGENRRGRFLKVSEASVSRNRSTIIVPAGSSPDEGWAAFRNILAEIHEASGLFVMPNQVKPSDGQEHLVDDVGAGFIPGHGSQQPSSSEHNVDRTIDSPGQEETGMTGVSKVIRADQKRFFFDLGNNNRGHFLRISEVAGSDRSSIILPLSGLKQFHEVIGHFVEITKDKIEGMTGANVRTVDPPQR
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MANPNNLRAVIRQIQQVGAKQVFRDICREGKLMTGVLVGQDKFGNKYYEDKEQMFGNHRRVDMAREDFNASQVPPEWHRWLHAMTDDLPDSFEPRQKWQLDHEENLTDSADRYVAYSTVKPKIQSWKPE
The following text describes a protein:
Function:
Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress.
Sequence:
MSDSAANFGHQLPDQLPTIAAALSAQLALENDVASFLAERAALEREYAAKLQSLIRKYRDKKAKKDQDISVGPTPTIEWKHTQSTLGTHITNIYSVNDATAADHSNLASVLDQLSNKMNTSTKSREELRRKHTVYASKLLSDRERMYSDKDKAKSKYDELCRELDSQRQKREKAAAGDRHADRAAKAFQSAEMDMWNGKNSYLIQIAVSNRAKERFYRTDLPAVQNSLQSLWVLSTRHFVACTSQAQAAVAAHHESVAKKHRDLEAKAAHVDPTQDQMLFVEHNQQRWQEPSGWSFEPCVGFFDTSEMSTEPSAVTFLQNRLMRCRSRIAELEPLLIAKAKEVDGLHNLCDAYQKQPDLGNPDEVMDNLFEATRTLYGFEIELHDLEAEVDTIIANIGENQGQARPHRFKPASFGIPTTCHFCRDKIWGLSKQGSVCKPCGYTVHQKCEMKVPAECKAAPGGGVAAGTDSPRASVSLSRSNRSSAIFDGKLDRSASTEGASASSKLSSALTGSDSSTQSPVGKVIYDFEASSPFELSVIEGEQVELLEDDVEGTGWIQVRAGAGREGLVPTSYCEFENAATGAMAALQDVGYKGGQGSTVAAQGCGRFVKALYEYAAQGDDEHSLATNEQLELSAVGMSYADGWCQVVKDGRTGIVPSNYVEQV
The following text describes a protein:
Function:
Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
Sequence:
MDVTAADVAMKEESLEPSVHGADSGTTLTPESNAKATLLQQTPQCEIPPFAQWFDMKTIHDIEKKSLPEFFDGKNKSKTPVVYKDYRDFMICAYRMQPDVYLTFTACRRNLAGDVCVILRVHRFLEQWGLINYSVRPETRPSKIAPPYTGHFQVYADTPRGLAPLVPPLAPSIPKSQSKPIQSVTANRKNIYNPETSNIISGTHSSTHATNSPALQQTKNGLNGPHNSLDLSCISCAKAVQNTTHYESNTPDRFQLCATCFEEQKFPNGLGLHNFVKIPSDNEQQEHKWTSQELLLLSEGIELYPNDWKKVSEHVGTKNADECILKFLQIPPSDAELHKAKDYEYRASIGFIQKENPIVSLVSFLAKLADPCSLAKDLNIDLHNISEQLRTESAKFPKEENGQEVKHELEGSTQDSSMEIDSEQANNEETSSKVKTEATDETTVESEREQAQPEKPSISVQNVPPEKGDLMQEDKKTEVNKDEERNSPNDAGTKKEGEKKTLSSEDEKSIIELNRKLVQKQIEKLTLRLSHFEKLEQHLRLESQELEKMRQDVYYEKLYMRRELLNSRRRLEQNIHNSDGVLPA
The following text describes a protein:
Function:
Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MAITKSTPAPLTGGTLWCVTIALSLATFMQMLDSTISNVAIPTISGFLGASTDEGTWVITSFGVANAIAIPVTGRLAQRIGELRLFLLSVTFFSLSSLMCSLSTNLDVLIFFRVVQGLMAGPLIPLSQSLLLRNYPPEKRTFALALWSMTVIIAPICGPILGGYICDNFSWGWIFLINVPMGIIVLTLCLTLLKGRETETSPVKMNLPGLTLLVLGVGGLQIMLDKGRDLDWFNSSTIIILTVVSVISLISLVIWESTSENPILDLSLFKSRNFTIGIVSITCAYLFYSGAIVLMPQLLQETMGYNAIWAGLAYAPIGIMPLLISPLIGRYGNKIDMRLLVTFSFLMYAVCYYWRSVTFMPTIDFTGIILPQFFQGFAVACFFLPLTTISFSGLPDNKFANASSMSNFFRTLSGSVGTSLTMTLWGRRESLHHSQLTATIDQFNPVFNSSSQIMDKYYGSLSGVLNEINNEITQQSLSISANEIFRMAAIAFILLTVLVWFAKPPFTAKGVG
The following text describes a protein:
Function:
Involved in a multicomponent binding-protein-dependent transport system for glycine betaine; probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVTGLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVIISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASVIFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIMLALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKKKSRGNA
The following text describes a protein:
Function:
Transmembrane mucin that may be involved in cellular adhesion and the innate immune response. Membrane-tethered mucins are involved in many cell surface functions and form a physical barrier around cells to regulate cell-cell and/or cell-substrate interactions, and protect against pathogens or harmful extracellular conditions. This mucin likely acts in hemocyte adhesion as it is released from hemocytes during coagulation and is also able to bind lipophorin particles which form part of the hemocyte coagulogen. Able to induce expression of the antibacterial proteins in the presence of GalNAc-specific lectins and so probably also functions in the innate immune response.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Note=Detected on membrane of hemocytes.
Sequence:
MGLLYALRVRIMNFMIFFLLIILMPGLPPRTTFPFKDYIVTPPKDLKGALESNFHLEGAERLLEGRVYGPECLIARNNEIYTGIHGGEVIKLTSNHVTHVTKIGQPCEDIYEESRCGRPLGLAFDTQGNNLIIADAYYGLWQVDLGTNKKTLLVSPAQELAGKSINRPAKIFNGVTVSKEGDVYWTDSSSDFTIEDLVFASFANPSGRLFKYNRSKNVSEVLLDELAFANGLALSPNEDFIVVAETGAMRLTKYHLKGAKAGQSEVFVDGLPGLPDNLTPDAEGIWVPLVQSADSEHPNGFTLFTRFPSVRLFLARMLALFELPFRYLNSVYPNKFSQRFVHFVGHMESITVLAPKRTTVVRVDWNGNIVGSLHGFDKSAATVSHVLEFQDFLFLGSPTNQYLARVKSPKAKQPTLKVRNVRVEGEGLEASIGVPPSKATPKPKAAPSTTTPKPTTTTTTTTPKPTTKTTTTTTTPKPTTTTTTKKPTTTTTTTTTTPKPTTTKPPTAKPSTTTTTTTTPKPTTTTTPTTPTPEPSKPKVKRTVPEKPAPVEEDIPSDTQPPKKEKLKVINKQGVNVEL
The following text describes a protein:
Function:
Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Domain:
The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
Sequence:
MAAPEAWRARSCWFCEVAAATTMEATSREAAPAKSSASGPSAPPALFELCGRAVSAHMGVLESGVWALPGPILQSILPLLNIYYLERIEETALKKGLSTQAIWRRLWDELMKTRPSSLESVTCWRAKFMEAFFSHVLRGTIDVSSDKRLCDQRFSPLLHSSRHVRQLTICNMLQGATELVAEPNRRVLETLASSLHTLKFRHLLFSDVAAQQSLRQLLHQLIHHGAVSQVSLYSWPVPESALFILILTMSAGFWQPGPGSLPCRLCGEASRGRAPSRDEGSLLLGSRRPRRDAAERCAAALMATRRKSEVKQVPRALPTSRVTRRSTQESLTIGGTDSKRELYPPATSYEASGTKQPSSAPTAASSSTSSKRAPASSVSQPKPLKRFKRATGKKGPRTRQGSGAESEDLYDFVFIVAGEKEDGEEMEIGEVACGALDGSDPSCLGLPALEASQRFRSISTLELFTVPLSTEAALTLCHLLSSWVSLESLTLSYNGLGSNIFRLLDSLRVLSGQAGCRLRALHLSDLFSPLPILELTRAIVRALPLLRVLSIRVDHPSQRDNPAVPENAGPPGHIIGDEEIPENCLEQLEMGFPRGAQPAPLLCSVLKASGSLQQLSLDSATFASPQDFGLVLQTLKEYNLSLKRLSFHDMNLADCQSEVLFLLKNLTLQEITFSFCRLFEKRPAQFLPEMVAAMKGNSTLKGLRLPGNRLGNAGLLALADVFSEDSSSSLCQLDISSNCIKPDGLLEFAKRLERWGRGAFGHLRLFQNWLDQDAVTAREAIRRLRATCHVVSDSWDSTQAFADYVSTM
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MFSRRVFGGTPDSFKLVLEYGRENTKAPMLGQVRLPMALATSEVTWNSEETVESVLERFTQAKSRVQLDRAEERLLVKLTPSPHGGDRVSLKLSVACLAPALRCVQVVRVTNSGNVSEPLLAALFKHCDLSGVWKLRGAEGFGNFWCSCCEVGSWAALANMNLSSCGLTALPAAVGALGSLRILRLSHNRLASLPPELSGLSSLEVLAADHNLLTALPAELRRCSALRHLELEGNRLATPVLDLRALSGLVSLQLYGNPLEYLPELSPASALRSLSLANVRIMADAAYTRWEVEVAALPYMSRVSHKLAPLFKLTFRRSSCQHPLLAGALGRISEDRAQCELMAREETAIQQLVLMALSEAPVVAEQACRTLGALAALGLGTARRLLAHDVLSTILTLLRSPRRASKLCGLGLLSSLAAASEAVAAELLSRELLALLADCVAAAEPDARAAALSALANLAFCRENKVKIRQAEGLVGRLVELATAGAAGGTGGAAAEAAGVERGGGGVGGLESAGAGLGLGEAAGGERAQALSRLSEQQTLIARQQQLLQAPASLGAAAAAAAAAAAAAAAAGGAGSDVSTGLVVNSRGSPVQQPTPSPPTSSASAAPAPGRKPAAAATAGQLHQQLVSAAQTPGTGTGTGIATFTLPSGAAASTSASTPLSASRPLSGSSAAPPPPPQQQPPPTPPAPAAVRMPMRAPGSNAGVSGEGGAGRISDTGAAAFSALLGSPPTASTSSGGGFLARHSAALMSTSPNSASAGGAGVVGVGGGGGVSGVSGGGGVGTSSSGHGMSVGGGAAGGEVLSPPQSSRPLHHSASTPAAVNLLASASALTSGGGAAAPTATTSTTTSAAIATGVTAVSPARVATGSGYGSVSMSGLPSGVMSPTSPPAASDAATAAALAGGLPAAIALAPPRRVPEVVAAQEPSRLLAIKVLAILGENEVVARAVGTPPIRGRGLRVLALDGGGMRGLALVQILRHIEKRTGRPLHGLFDLVVGTSTGAIVAVGLGVFHFSLDQCEAIYTGLGHKVFNQAAAKSGAATPREELAMAAQAQAAAQAAGAAAAAAAAASGGGAAAAAAAGGAGAGAEGGWRDSLFRVVRGTSTSLRVAVYGFKHDASTFEELLRQMCEVKKLGCVGNQMIDAAALGGPKVAAVATLVSVCPVTPFLFTTYELPPEVEPLAAALRAGPASSRHLIWQAVRASSAAPYYLDDFLCGEDRFQDGAATANNPGILALQQARLLWPNTPVEALVSVGCGAAPSVRREKGAHAMLDTGAVLVDAATSPDRADEALSTLLPLVPGCRYFRFQPVHERCAMELDDVDPAHWAALQAAVDDYCGVHGDRFDDLASLLLTALPPQPHELEAAEAAAAAAAAAAAEAAGEGEEGEQGGEEEAWEAAGAGGSAGGALGPDGLPLSRVPRIRLGPRRGFMLLEAPEPEADTPAAATIASPSSGPTGVSAATASGQSLAPSSASSRGGGSGGDSSGRSRPPPAYQAAVEAAVLEALSRQPHLVRRCDVAAAAADDALCSSLVSSHLQRLQQQAQEEEELEREERERAATAAAAAAAAAAEGEVKEEGASSSGAVGVTAVADGMPAGADAAGAHSVAHRHLGAGDVASPSSRTADASTPMASASVAAAAAAAAAVAAAADSSSGGQAAGAGVVTGGGAGGAGTGPARSGHSLLSPRGSNFRGWSSLSRGGAAGAAAGLPGSGSGGMEDAAAEVATAAAGTGVADAAAEAAAVAAHDGGGGGSTASAAAAAAAQPSSLFEYFFGNTGSGASTSSGGASAAKKPAAMPAAGAAGGAAGSGVTVAPPSGGGGGGSGGAGAPHATPAVPPLPLARVTGASAGGGGGGGVAASAVPGRAGDGGGGGGGGGGVAPSARPLQGEAGNASSSVSPLLLSTPHTAAAAASGSLAAAARPPAGPPPPPRAALLLGALLSDATERCGLLHLSLPVAAVPAAAAAAAAAAAAAAAVGEAGGEGRGGGLPLLGSGEGDEGEGEGEEGEEEELALVTGWRQDVVAVVEPGPDADLILRRLGHAHARTSASTSAPTPTPAPTLSSLFSAAPGACLLDARRCVRYRQLARQEVWHGGRQLATLLLQVTRPAAALRPAALAALSRELGGLVVTAAAPLPAAVTAGLLRAGARAVVCPDRPLVGPEVLGALGREQGREEGQGEGEGEGVGAMAAVGVPQLVAARESISFGGATPGVQELLARQGKHERTGGVGHTRDEGGVGAAAAVTAEAAAAFYGVLVREMTCRGASVVEAIAAAERSCPALRGRVALHHL
The following text describes a protein:
Function:
Probably participates in efficiency of electron transfer from plastocyanin to P700 (or cytochrome c553 in algae and cyanobacteria). This plastocyanin-docking protein contributes to the specific association of plastocyanin to PSI.
Sequence:
MKHLLALLLAFTLWFNFAPSASADDFANLTPCSENPAYLAKSKNFLNTTNDPNSGKIRAERYASALCGPEGYPHLIVDGRFTHAGDFLIPSILFLYIAGWIGWVGRSYLIEIRESKNPEMQEVVINVPLAIKKMLGGFLWPLAAVGEYTSGKLVMKDSEIPTSPR
The following text describes a protein:
Function:
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Sequence:
MTKKIVAIWAQDEEGVIGKDNRLPWYLPAELQHFKETTLNHAILMGRVTFDGIGRRLLPQRETLILTRNSEEKIDGVTTFQDVQSVLDWYQAQEKNLYILGGKQIFQAFEPYLDEVIVTQIHARVEGDTYFPEEFDLSLFETVSSKSYTKDEKNPYDFTIQYRKRKEV
The following text describes a protein:
Function:
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
Sequence:
MLLKRYRHKIKTLEELCEIVGQFPREKTVVMCHGVFDVVHPGHLRHLLYAKSKADILVASLTSDRHIVKGHYRPHIPQDLRAANLAAFEMVDYVLIDKYPTPLQTIQALQPDLFAKGFEYISGGLHPKTAEEEELLKAYGGKMLFTPGDIIYSSSALINMNEPDVRHEKLATLLEYHQVSFADIERALDEMKDIRVHVVGDTIIDGFNYTSMIGGQTKTPTISVRHESQKDYVGGAAIVAQHLRAAGAQVTFTTLLGADDRKDFTLNVLSKNEIKVNAIIDENRPTTYKNAIIADGYRLIKVDTLDNSSINDDCLAQFEKAIDNTDCDVVICSDFRHGIFNRRTIDRLLSVIPPQVFKVADSQVASRWGNITEFRNFDLITPNEREARFALADQDSGIRPLASKLYDIANCKTLILKLGEKGILTYYDSDHEALDSFFVVSSFVDRVVDCVGAGDALLAYATLALVKGASPVIASILGAVAAACECEMEGNQPVTPDNVREKLLKLKTCLDSSDFQSIKENETLVT