lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.
Sequence:
MPSFGQMVIGPPGSGKSTYCAGMLEFLTGLGRKVAVINLDPANDQLPYKCAVDISSLISLSDVMDNLKLGPNGGLIFCMEYLEKNLDWLENQLKALEGHYFVFDCPGQVELYTHHASVRNIVKQLEKWDSRLVAVHLVDSHYCSDPGKFISVLLTSLCTMIQVELPHINVLSKIDLIENYGKLAFGLDYYTEVLDLQFLVEHLNDSPFGSKYKKLNKALGSLVEDYGLVSFLTLNVQDRESMFGVVKAVDKANGYVFGAKYQETNFSALLSSAVGADFEFFKTASVQEQYVGSSRGEADS
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. Modulates outer kinetochore KMN network activity by regulating interactions within the network.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MASHNYETPLKSSSFQHLVGTLSQRRHFTPSRSRYTPRSAQRTVTPHKRRALARRNSLARRRSNVFSATTPRDILRMLSRALAKNPVPSPAESESSERRHTPQTNSQKSQKTPRLSSNKRRTLKNDAKQRNSQSPGTDTSDANLTIQSIEAPRRAPQRLSDFFTPDGRRVSNIRDSLISEKRLENNIDQVQESALSTASSNRLIDLKNDEVPIFRIPLSDYETDDMDDGTPLQRHVATLNQYQSPIFNLGPDILEDEPSYSSRASRSRQSSLSSRLSELPSKRASLEILRRENTFPADPIQEFGEKAYNERELMEEISNFEPLLDDNLLENANEAVNSPVVDAPMDADSALEIPNDEDNGEILNKLKDSPFKKPKRRYSKSSTLVLPETNIRKLANSYSQKKIAGSVIEELTTASELFFKQIANDLSAFADHAHRKTIDTQDVVLLMKRQRKISEKKSLSSLMQQYLSREIAPPAIKRT
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
Subcellular Localization:
Peroxisome membrane.
Sequence:
MSDSDNETKKPDVPAWQLQGDEKQSDEPGEAVVEPPSRTSILEQARKFLEEDEVKNASADKKIAFLESKGLGGDDIKELLGVSRDDEAPNTSLVKTPEAKPQPQRQPQPRSLPPTTQASYSPAPRDQPPIITYPEFLVQPSPSSPLITKHRLLTTLYLFGSFSFLLYGTNTFLIRPMLNTLTESRRSLSSATLNNLQKLIHKLENSVSEIPPTYHYRKSFQSDYLDSDSSSGTLSSLLEDSTYESSANEELETRMTMLKEYLQGLVFPAPFNYRSGAYSDGRDRNGNDKEGEDEFAKVKREIRGVKGVLLSARSFPGGVRAK
The following text describes a protein:
Function:
Matrix metalloproteinases (MMPs) or matrixins may play a role in the degradation and remodeling of the extracellular matrix (ECM) during development or in response to stresses (By similarity). Active on McaPLGLDpaAR-NH(2) (QF24) and beta-casein and, to some extent, on myelin basic protein (MBP).
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Domain:
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Sequence:
MVRICVFMVFLLFFAPSPVSAGFYTNSSAIPPQLLRNATGNPWNSFLNFTGCHAGKKYDGLYMLKQYFQHFGYITETNLSGNFTDDFDDILKNAVEMYQRNFQLNVTGVLDELTLKHVVIPRCGNPDVVNGTSTMHSGRKTFEVSFAGRGQRFHAVKHYSFFPGEPRWPRNRRDLTYAFDPRNALTEEVKSVFSRAFTRWEEVTPLTFTRVERFSTSDISIGFYSGEHGDGEPFDGPMRTLAHAFSPPTGHFHLDGEENWIVSGEGGDGFISVSEAVDLESVAVHEIGHLLGLGHSSVEGSIMYPTIRTGRRKVDLTTDDVEGVQYLYGANPNFNGSRSPPPSTQQRDTGDSGAPGRSDGSRSVLTNLLQYYFWIIFGLFLYLV
The following text describes a protein:
Function:
Specifically deaminates 8-Oxoguanine (8-oxoG) to uric acid. 8-oxoG is formed via the oxidation of guanine within DNA by reactive oxygen species and leads, if uncorrected, to the incorporation of 8-oxoG:A mismatches and eventually to G:C to T:A transversions.
Sequence:
MSRTWIRNPLAIFTANGLDAAGGLVVEDGRIVELLGAGQQPAQPCASQFDASRHVVLPGLVNTHHHFYQTLTRAWAPVVNQPLFPWLKTLYPVWARLTPEKLELATKVALAELLLSGCTTAADHHYLFPGGLEQAIDVQAGVVEELGMRAMLTRGSMSLGEKDGGLPPQQTVQEAETILADSERLIARYHQRGDGARVQIALAPCSPFSVTPEIMRASAEVAARHDVRLHTHLAETLDEEDFCLQRFGLRTVDYLDSVGWLGPRTWLAHGIHFNAEEIRRLGEAGTGICHCPSSNMRLASGICPTVELEAAGAPIGLGVDGSASNDASNMILEARQALYLQRLRYGAERITPELALGWATRGSARLLGRSDIGELAPGKQADLALFKLDELRFSGSHDPLSALLLCAADRADRVMVGGAWRVVDGAVEGLDLAALIARHRAAASALIAG
The following text describes a protein:
Function:
DNA-binding protein that plays a critical role in nucleoid compaction, genome replication and DNA replication and transcription. Binds to both ssDNA and dsDNA with a binding site covering about 15 nucleotides. Displays DNA-supercoiling activity only when associated with the viral DNA topoisomerase 2.
Subcellular Localization:
Virion.
Sequence:
MAVLYKSFQSVLEDKNHKKMFHPRVIYTANISTSQIAKEIAAYSSLSPGDVKNTLDNLVTVMGQHLQASESVSLDGFGTFRMVMKSNGKGVETSEEVSAAQASLTVRFLPNFTKNPDRTTATRSLVTGAKCVRFDRTDTPASGSGNTNKPGGGDGGEGGGEEAPDPTV
The following text describes a protein:
Function:
Catalyzes the depolymerization of methylglucuronoxylan (MeGAXn), a beta-1,4 xylan in which 10% to 20% of the xylose residues are substituted with alpha-1,2-4-O-methylglucuronate (MeGA) residues, which is predominant in hemicellulose fractions of hardwood and crop residues. Generates xylobiose (X2) and aldotetrauronate (MeGAX3) as the predominant products of MeGAXn hydrolysis; these products are then directly assimilated by the bacterium for subsequent metabolism. Thus, allows the bacterium to efficiently use polymeric MeGAXn as a growth substrate.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MSRSLKKFVSILLAAALLIPIGRLAPVAEAAENPTIVYHEDFAIDKGKAIQSGGASLTQVTGKVFDGNNDGSALYVSNRANTWDAADFKFADIGLQNGKTYTVTVKGYVDQDATVPSGAQAFLQAVDSNNYGFLASANFAAGTAFTLTKEFTVDTSVSTQLRVQSSEEGKAVPFYIGDILITANPTTTTNTVYHEDFATDKGKAVQSGGANLAQVADKVFDGNDDGKALYVSNRANTWDAADFKFADIGLQNGKTYTVTVKGYVDQDATVPSGAQAFLQAVDSNNYGFLASANFAARSAFTLTKEFTVDTSVSTQLRVQSSEEGKAVPFYIGDILITETVNSGGGQEDPPRPPALPFNTITFEDQTAGGFTGRAGTETLTVTNESNHTADGSYSLKVEGRTTSWHGPSLRVEKYVDKGYEYKVTAWVKLLSPETSTKLELASQVGDGGSANYPSLASKTITAADGWVQLQGNYRYNSVGGEYLTIYVQSSNATASYYIDDISFESTGSGPVGIQKDLAPLKDVYKNDFLIGNAISAEDLEGTRLELLKMHHDVVTAGNAMKPDALQPTKGNFTFTAADAMIDKVLAEGMKMHGHVLVWHQQSPAWLNTKKDDNNNTVPLGRDEALDNLRTHIQTVMKHFGNKVISWDVVNEAMNDNPSNPADYKASLRQTPWYQAIGSDYVEQAFLAAREVLDENPSWNIKLYYNDYNEDNQNKATAIYNMVKDINDRYAAAHNGKLLIDGVGMQGHYNINTNPDNVKLSLEKFISLGVEVSVSELDVTAGNNYTLPENLAVGQAYLYAQLFKLYKEHADHIARVTFWGMDDNTSWRAENNPLLFDKNLQAKPAYYGVIDPDKYMEEHAPESKDANQAEAQYGTPVIDGTVDSIWSNAQAMPVNRYQMAWQGATGTAKALWDDQNLYVLIQVSDSQLNKANENAWEQDSVEVFLDQNNGKTTFYQNDDGQYRVNFDNETSFSPASIAAGFESQTKKTANSYTVELKIPLTAVTPANQKKLGFDVQINDATDGARTSVAAWNDTTGNGYQDTSVYGELTLAGKGTGGTGTVGTTVPQTGNVVKNPDGSTTLKPEVKTTNGNAVGTVTGDDLKKALDQAAPAAGGKKQVIIDVPLQANAATYAVQLPTQSLKSQDGYQLTAKIANAFIQIPSNMLANTNVTTDQVSIRVAKASLDNVDAATRELIGNRPVIDLSLVAGGNVIAWNNPTAPVTVAVPYAPTAEELKHPEHILIWYIDGSGKATPVPNSRYDAALGAVVFQTTHFSTYAAVSVFTTFGDLAKVPWAKEAIDAMASRGVIKGTGENTFSPAASIKRADFIALLVRALELHGTGTTDTAMFSDVPANAYYYNELAVAKQLGIATGFEDNTFKPDSSISRQDMMVLTTRALAVLGKQLPAGGSLNAFSDAASVAGYAQDSVAALVKAGVVQGSGSKLAPNDQLTRAEAAVILYRIWKLQ
The following text describes a protein:
Function:
Acts to keep host cells in a proliferation-competent state upon differentiation. Enhances host epidermal growth factor receptor (EGFR) activation after stimulation by EGF by inhibiting EGFR internalization. Induces a redistribution of host caveolin-1 and glycosphingolipid (ganglioside GM1) components of lipid rafts to the plasma membrane. Since GM1s inhibit cytotoxic T-lymphocytes, block immune synapse formation, and enhance proliferative signaling by the EGFR, E5 may enhance immune evasion and cell proliferation via a common mechanism. E5 also alters endosomal pH by interacting with the vacuolar H+-ATPase, which is a proton pump responsible for acidifying cellular organelles. Additionally, E5 prevents transport of the major histocompatibility class I to the cell surface and retains the complex in the Golgi apparatus. Binds and prevents host ZNT1-TMC6-TMC8 complex-mediated inhibition of transcription factors induced by zinc and cytokines in keratinocytes.
Miscellaneous:
MISCELLANEOUS: HPV16, in comparison to HPV types 6 and 11, is more often associated with malignant genital cancers in humans; MISCELLANEOUS: Part of the antigens expressed and presented within HPV-positive head and neck tumors.
Subcellular Localization:
Host membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane. Host Golgi apparatus.
Sequence:
MTNLDTASTTLLACFLLCFCVLLCVCLLIRPLLLSVSTYTSLIILVLLLWITAASAFRCFIVYIIFVYIPLFLIHTHARFLIT
The following text describes a protein:
Function:
Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Atypical expression also suggests nongustatory roles in the nervous system and tissues involved in proprioception, hygroreception, and other sensory modalities. It is also possible that it has chemosensory roles in the detection of internal ligands.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDIEMAKEPVNPTDTPDIEVTPGLCQPLRRRFRRFVTAKQLYECLRPVFHVTYIHGLTSFYISCDTKTGKKAIKKTIFGYINGIMHIAMFVFAYSLTIYNNCESVASYFFRSRITYFGDLMQIVSGFIGVTVIYLTAFVPNHRLERCLQKFHTMDVQLQTVGVKIMYSKVLRFSYMVLISMFLVNVLFTGGTFSVLYSSEVAPTMALHFTFLIQHTVIAIAIALFSCFTYLVEMRLVMVNKVLKNLAHQWDTRSLKAVNQKQRSLQCLDSFSMYTIVTKDPAEIIQESMEIHHLICEAAATANKYFTYQLLTIISIAFLIIVFDAYYVLETLLGKSKRESKFKTVEFVTFFSCQMILYLIAIISIVEGSNRAIKKSEKTGGIVHSLLNKTKSAEVKEKLQQFSMQLMHLKINFTAAGLFNIDRTLYFTISGALTTYLIILLQFTSNSPNNGYGNGSSCCETFNNMTNHTL
The following text describes a protein:
Function:
Organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in a tissue-specific manner (By similarity). May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta (By similarity). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
A conserved histidine residue in the third TMD (His-190) may play an essential role in the pH sensitivity of SLCO4A1/OATP4A1-mediated substrate transport.
Sequence:
MPQHAMGDKHFLSLPKHLFTSTSSTTDSGCDTPPSSRASPASLRSAHGALGSSSQPLFEPQVEKRSSQAACEVQYLSSGPQSTLCGWQSFTPKCLQVFNTPKGFLFFLCAASFLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLGIGSLVFALPHFTAGRYEVEIDDEGLGTETGTCLTNQSQVECKDRASGLSSYRLIFMLGQLLHGVGATPLYTLGVTYLDENVKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQRTELTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYPRQLPGSQRYVVMRAAETQQLKDHSRDNPAFGKTVRDLPLSVWILLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSLLAFFVFLMHCPNVHMAGVTTGYVGSLLPKGQLDLKAACNALYCCQPRHYSPLCGSDGTMYYSPCYAGCPEGAVTGPGGQKVYRGCSCILEKASSGWGNATAGKCASTCQSKPLLLVLVFVVIIFTFLSSIPALTATLRCVCDRQRSFALGIQWIVVRTLGSIPGPIAFGWVIDKACLLWQDQCGHQGSCFVYKNEAMSRYLLIAGLTFKVLGFLFFVAAYFLYKSPSVSSDGLEASLPSQSSASDSPTEQLQSNV
The following text describes a protein:
Function:
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Subcellular Localization:
Nucleus.
Sequence:
MSMDVIFRVHEQEFISDAVDFGIFLSEAVAERNRSFSLLGEDGARKANASSEDFALYAGTDEKTAENVFDIIEFDLHGNVRGEDANEITVADELIVACSIYYGYSRPLQYDERRLGRLMKVTDKLQLLGSSTLLDLKNAFQCPSDISFAEDMSTCLPHPQYLAKYRFPNSYFFIHDTFYVDDTVADEVQMDLSEIVRDWAREKEYIGEMKVASMSQTRLVDLKARLGMPYLYVHQGQCEHLICFTDLKLWESRDMPHSYYPIKMQEKNFRRVCCIGCKMNTAEWVIIESDRLPFTPAFMCHNCYEEFNYTKERNKIGNFKAVPYCDRKAMDKKSTLFIEKLFDICIKMQEGAFGNQMINYSLDEDLIKPDKEELDRAMRSYYDQDEMKKSHVLKTIKREISDETYPYVRMPNTKDNVPFKAPEKIITLNNVYDLMEL
The following text describes a protein:
Function:
Acts as a component of the outer kinetochore KNL1 complex that facilitates microtubule-kinetochore interactions and the spindle assembly checkpoint. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MEAQLHELQEEITRSSDLVLTEQDKRLQGTLREIDQSIRKLIETSDYLKLSGDADSLIDIKQLEVKSRELDSLMDLLRKLYWREESLDLFLKYTINSDAEQVPVFSDTDPKYQSLQDEVSHLRDDVMTVKNQEIDQITGEILQVAHEITEKQDQVNMLYLETTNELDKCWELLDEWQRLQDDQRITKNEDNSNRKDTELNAMEECYEEWKTLEELAVLNDNLQKQIDELEKVDNKAINSTQLAEESIVNTVQLNDLIDMWKRRIIASIHEDISEIVLYPYSRKLQLRVANRYTIIIQLDKHQTHDGKSTIHDIDLFTEQDSRIIPMRELRKQVLQECKGHSNILQALKNIINRVINNDN
The following text describes a protein:
Function:
Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.
Sequence:
MADAYRERALPTLSVLERLRCLRREHVPYASHYCEENAYKLVEALYRDFSLPDHAVFAVFISNDCKSTPVWKQRLGNGRCPLMWDYHVITLVNVGAGDEGGMWAFDQDTTLPFPCEGLRYIEESFHPEMQLDDKYRQRFRVVPGRDYLEYFSSDRSHMKDFDAAQPPWPLIRGCRAPSDMRLGLYVDVHQSSSGEDVKKEQGCGKILSIAELISFVSP
The following text describes a protein:
Function:
During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3.
Sequence:
MTSILWLFSLAVLWHMGQPQPAELYPSVDPNHFGADGNPCYDRATRQPQRCVPDFVNAAFNLEVQVTNTCGTKRPTKFCVQSGHTGQRSVCETCDDRHEGFSHPAKYLTDFNVGNNETWWQSDTMQEGQQYPTTTNLTLVLGKSFDITYVRLKFISPRPESFTIYKKTHTDSEWEPWQFYSGSCRATYGLSDRAPILPGNEATAQCTKEFSDISPITGGNIAFSTLEGRPSAHAFEESEVLQKWVTASAIRISLNRMNTFGDEVFKDPQVLRSYYYAISDFAVGGRCKCNGHASECVGSSSVDGENRLVCRCEHNTQGADCNECLPFYNDRPWRSGTSVEANECIACNCSQLSNRCYFDQQLFEETGHGGHCIDCQGNTQGVHCEQCIANHWRRPGENYCVACGCNEIGSLSTQCDNEGKCQCKPGVTGRFCDQCLDGFYDFSTNGCKNCGCETSGSLNNQPRCDSSSGSCSCKLNVEGRQCDKCKPGYFDLSTENQFGCTPCFCFGHSSICNTADGYFAMNVSSVFDQDKQKWAGQNRIGLQDTQWAELDKAVAVSDTDNSPVYFVAPEQFLGDQRSSYNQDLVFTLKVAKHVTNQDVKDIIIVGADRQELSTSITAQGNPFPTTEAQTYRFRVHADPYFGWYPRINELDFIGILSNITAIKIRGTYSYKDIGYLSNVNLGTAGVAPSAANPKQATWIEHCECLPGFVGQFCESCESGFRRETKFGGPFNHCIKCDCHNHSNSCEAESGSCICEHNTAGDTCERCARGYYGDALQGTEEDCQKCPCPNDGPCILHADGDVICTECPNGYTGRRCDECSDGYFGNPKDGTECVECACSGNTDPNSIGNCDKITGECKKCIFNTHGFNCENCKPGYWGDALIEPKGNCQSCGCFAAGTRRPNNDYTLLECNQQDGQCDCLPNVIGIQCDQCAHGFYNITSGLGCQECNCDPLGSEGNTCDVNTGQCQCKPGVTGQRCDRCADYHFGFSANGCQPCDCEYIGSENQQCDVNSGQCLCKENVEGRRCDQCAENRYGITQGCLPCDDCYTLIQSRVNVFREKVKSLDNTLQEIIENPAPVNDTKFDEKVKETSRAASEVWEAVKQKTKEGGGTIKTKSKAIKDEIVAALEKLTSIDESVAQAKVGADAAENDMKRWEIIIENARREIENVLHYLETEGEERAQIAYNASQKYGEQSKRMSELASGTREEAEKHLKQASEIEQLSEQAIANATQANKEASDAIYGGEQISKQIAELKEKQNQLNESIHRTLDLAEEQKKSADEANNLAAVSLTNVEAVKIPSVDPKELRNDVAGVLEESENLVDSSVKENSANDELFDEVNRSVADARNELQSSQDQQRVSDQLMLELEKSRERIVDSVSTADKTLKDAEAALQVLEEFGAKIEKSRNDAVAEFAGVEGINQRLDDIIDAQDKRRNSLPIDKQFVIDYRKSADVLLNETHALADRYKDIIHSDVDTRDSTEAVQYDIEQLMEELTDSNENLQYYKKQAEDDKQMATEAVRKATLAKNSAIEANATILAEEDEIKKIINSLDTMEEVNNAELDELEEEIDRLDQLLAQAQLAKEVPTYQQYRADEDVKVAQLKNDISELQKEVLNLEEIRDNLPTKCFNVINLEQEGQK
The following text describes a protein:
Function:
DNA-dependent ATPase and 5'-3' DNA helicase. Unwinds D-loops, R-loops, forked DNA and G-quadruplex DNA.
Sequence:
MLPDNVKNQIRAIYKDIAASLPNFRPRREQNFMVAEISKTLAGDYDKDRRIIVVEAGTGIGKSLSYILGTIPLALASKKKVCIATATVALQEQLLHKDLPFFLEQSGLNFRFGLVKGRQRYVCLSKLAMLIGDDNSTQMAMWQTKPDNSQIAMLQTLLNDVNEGRWNGEIDTLSTPIPDHLWQQIACDKHSCHRQLASHRNCPFHKAREDVDTWDVLIANHSLLFADLELGGGVILPNPEDVFYVIDEAHHLPIVARDFSSAQATLRGAADWLEKVGKTSAKLQNQIKSNNIIAPAQAMQDHIGDLIGQLNQVAHYCDTQTKQFANPESRYRFEHGKLPGALKIPAENLAATSNLALKQFNKMQLLLAEAIKDGDIPKHQAEALQAEMGFMLQRLENLQKLWKMMAKEDSNKGAPMARWIELITGKQVDYLFSASPIEVGFMLETMLWQKAAGVVLCSATLRALNNFDHFAHQVGLSLKDGSRYLALQSPFDYPNNATLYLPKMKTEPTDDAYTAELAEQILQLIEGEMATLVLFASYWQMEKVAELLEGKLALEILIQGNAPRQQLLETHKAKCDKGEPSILFGTGSFSEGLDLPGDYLTNLIVTKLPFAVPTSPVEQAHAEYVKIKGGNPFLQLTIPDASRKLIQSCGRLLRKEQDYGRVTILDRRLVTKRYGKSLLDALPPFRRVIE
The following text describes a protein:
Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Does not glycosylate apomucin or SDC3.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Domain:
There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding; The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
Sequence:
MAVARKIRTLLTVNILVFVGIVLFSVYCRLQGRSQELVRIVSGDRRVRSRHAKVGTLGDREAILQRLDHLEEVVYNQLNGLAKPIGLVEGPGGLGQGGLAATLRDDGQEAEGKYEEYGYNAQLSDRISLDRSIPDYRPRKCRQMSYAQDLPQVSVVFIFVNEALSVILRSVHSVVNHTPSQLLKEVILVDDNSDNVELKFNLDQYVNKRYPGLVKIVRNSRREGLIRARLQGWKAATAPVVGFFDAHVEFNTGWAEPALSRIREDRRRIVLPAIDNIKYSTFEVQQYANAAHGYNWGLRCMYIIPPQDWLDRGDESAPIRTPAMIGCSFVVDREYFGDIGLLDPGMEVYGGENVELGMRVWQCGGSMEVLPCSRVAHIERTRKPYNNDIDYYAKRNALRAAEVWMDDFKSHVYMAWNIPMSNPGVDFGDVSERLALRQRLKCRSFKWYLENVYPEMRVYNNTLTYGEVRNSKASAYCLDQGAEDGDRAILYPCHGMSSQLVRYSADGLLQLGPLGSTAFLPDSKCLVDDGTGRMPTLKKCEDVARPTQRLWDFTQSGPIVSRATGRCLEVEMSKDANFGLRLVVQRCSGQKWMIRNWIKHARH
The following text describes a protein:
Function:
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
Sequence:
MSVYNPNDADFAFTLGIEEEYQIVDPETRELRSYITQILEPGRTILREQIKPEMHQSIVEVGTRPCRTISEARAEIVRLRSAIAGLAARHNLRIVAAGTHPFSSWMQQEITPDERYHMVVGEMQDAALQLLIFGMHCHIGMPNNEVAIELMNVARYICPHLLALSTSSPFWMGRNTGFKSYRSVIFSTFPRTGIPPTFHSASEFERYVQLLVNTGCIDNGKKIWWDLRPHPFFGTLEFRVCDIATKVEECLALAATMQALIVKFYTMFEENTTFRVYRRALINENKWRAQRWGLDGKLIDFGKRKEVEAKALVHEIVELVDDVVDMLGSRREVEYLLKIVENGTSADRQLRVFAETNDLKAVVDNLMVETMEGVPAMAFEADVQSQAAHS
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane; Peripheral membrane protein.
Sequence:
MTSSYKDQFPHYNLTHSLSLPWKPSTYYKTFSNFPTLDPYCTRSQRVSESTMRPFVSNRTTLFTRYTPDDWYRSNLTNYQESDTSRYNSERLRVDTSRLIQDKYQQTRKTQADSTKNLGERVNDIGFWKSEIIHELDEMIGETNALTDIKQKLERALMETEAPLQVARECLFHREKRMGIDLVHDEVETQLLTEVDIILCCQERMKLHLDKAIAQLAANRASQHELEKDLSDKQTAHRIDDKCHHLRNTSDGVSYFRGVERVDATVSVPESWAKFTDDNILRSQSERAASAKLRDDVQNLLVVTANEMWNQFNRVNLAFTNRIAETADAKNKIQMHLAKTLQEIFQTEMTIESIKKAIKDKSAFLKVAQTRLDERTRRPNIELCRDMAQLRLVNEVYEVDDTIQTLQQRLRDAEETLQSLVHTKATLEHDLAVKANSLYIDQEKCMSMRKSFPNTPRLVGFC
The following text describes a protein:
Function:
Metalloprotease.
Subcellular Localization:
Secreted.
Sequence:
MQILPIFFPLLITSLHAIPRGRRAVRNRNEGDINSLVGVGQYLYQGDIAVVKSRARRAVIRQKHKKWKLPMPYSFDRNFPSRSRQRVLEAMQFWSEKTCVTFHENRYVYPHVSIFEGNGCWSFVGKQPSLREQSLSLERSCTDHTFVVAHEIAHTLGFYHEHARGDRDQFISIDYSNVNPNLTFAFAKESEKQLDHQEAAYEYGSVMHYSVDQFAVNTNRPVIYARDQKFAQAMGNRMRATFQDVSRMNVLYNCHERCANTLNRCQQGGYPAPSDCSQCVCPDGFGGNFCETIEAHSVGQKDNSDCGGVLWASETSQTFYGAVRTRVHSNSVLPTPEHCFWHIRASQGKSIEIQIKNIISPCSMSCSFNALELKLSNFTMTGPRFCCDEHIYNRYSQPKVFQSEGPLAVIGAYARYDYLDFNIEYRAV
The following text describes a protein:
Function:
Transcription regulator. Binds specifically to the MEF2 element, 5'-[TC]TA[AT][AT][AT][AT]TA[AG]-3' in the regulatory elements of target genes, such as chemoreceptors str-1 and srh-234. Involved in transduction of sensory signals, together with egl-4, kin-29 and hda-4; binding to histone deacetylase hda-4 enables negative modulation of chemoreceptor gene expression in chemosensory neurons. In response to starvation, negatively modulates expression of chemoreceptor srh-234 in ADL sensory neurons, acting in concert with basic helix-loop-helix (bHLH) transcription factors. Plays a role in regulating muscle sensitivity to acetylcholine (ACh) and the magnitude of presynaptic ACh release via a retrograde signal, perhaps by indirectly decreasing Ras-related protein Rab-3 activity.
Subcellular Localization:
Nucleus.
Sequence:
MGRKKIQITRIQDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIVFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNNDIMEALNRKEGNQGGGNSDDESPGPSTSPVIQITMPAVVNGHSSNNSVASAASASAAAVAAAAAAVAAVEGTSSGAAAAAAALQASNAQRHHNLNLYQNLIFNPNYTRHLNQRNDPLSSTSVAPSSSSSKHLDFPPSTSFAYDTSRLHPIAAADADCDLVPSSRAAADQNIWSSALQQRPVSQPAPSISNSSTNGISNGTSSLLSPNVSSLNGHSVLDLGGPNLPYKLDPNTYVKMEPHSPPEKRPRITTEWRPQQLT
The following text describes a protein:
Function:
High-affinity transport of valine and tyrosine. Low-affinity transport of tryptophan. Can also transport L-cysteine.
Miscellaneous:
MISCELLANEOUS: Present with 504 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDDSVSFIAKEASPAQYSHSLHERTHSEKQKRDFTITEKQDEVSGQTAEPRRTDSKSILQRKCKEFFDSFKRQLPPDRNSELESQEKNNLTKSIKSRHLVMISLGTGIGTGLLVGNGQVLGTAGPAGLVLGYGIASIMLYCIIQAAGELGLCYAGLTGNYTRYPSILVDPSLGFAVSVVYTIQWLTVLPLQLVTAAMTVKYWTSVNADIFVAVVFVFVIIINLFGSRGYAEAEFIFNSCKILMVIGFVILAIIINCGGAGDRRYIGAEYWHNPGPFAHGFKGVCTVFCYAAFSYGGIEVLLLSAAEQENPTKSIPNACKKVVYRILLIYMLTTILVCFLVPYNSDELLGSSDSSGSHASPFVIAVASHGVKVVPHFINAVILISVISVANSSLYSGPRLLLSLAEQGVLPKCLAYVDRNGRPLLCFFVSLVFGCIGFVATSDAEEQVFTWLLAISSLSQLFIWMSMSLSHIRFRDAMAKQGRSMNEVGYKAQTGYWGSWLAVLIAIFFLVCQFWVAIAPVNEHGKLNVKVFFQNYLAMPIVLFAYFGHKIYFKSWSFWIPAEKIDLDSHRNIFVSPSLTEIDKVDDNDDLKEYENSESSENPNSSRSRKFFKRMTNFWC
The following text describes a protein:
Function:
May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.
Subcellular Localization:
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Recruited to the cell membrane by interaction with membrane proteins.
Sequence:
MSYIPGQPVTAVVQRVEIHKLRQGENLILGFSIGGGIDQDPSQNPFSEDKTDKGIYVTRVSEGGPAEIAGLQIGDKIMQVNGWDMTMVTHDQARKRLTKRSEEVVRLLVTRQSLQKAVQQSMLS