lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body. At the exit of mitosis, localizes to the basal body and ciliary base of the forming primary cilium where it recruits and activates RAB8A to direct vesicle-mediated transport of proteins to the cilium. Also recruits the BBSome, a complex involved in cilium biogenesis, by bridging it to PCM1 at the centriolar satellites of the cilium. It is also required for the recruitment to the cilium basal body of the intraflagellar transport (IFT) machinery as well as the ciliary appendage proteins CEP164 and NINEIN. Functions as a regulator of Hedgehog signaling both through its role in cilium assembly but also probably through its ability to retain GLI3 within the cytoplasm. It is involved in spermatogenesis through its role in organization of the basal body and assembly of the sperm flagellum. Also indirectly involved in heart development through its function in ciliogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus.
Sequence:
MVRAGRWRCPGDAGRGAAPLASPGRGGPPPHPHAVRSPQPFQKHVYYPLAGCPEGPGAPAAAAMACAPHRAASGPLPCFQFRPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCAHCQSGVDPVLLKLIRLAQLTIEYLLHSQEFLTSQLHHLEERLRLSLEEGEQSRTLLSKQAGEIKLLKEECKRRKKMISTQQLMIEAKASYYQCHFCDKAFMNQAFLQSHIQRRHPEDSHLEYKQKAQTDKLQSEIDMLKEQLQLTKSQLEAAQHAHAVRFSKEYEMQKTKEEEFLKLFDRWKEEEKEKLVSEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEERPQYSQDFQNVMQLLDSQESKWTARVQVLHQEHKKEKGRLLSHIEKLRNSMIDDLNSSNIFYKKRIEELGQRLQEQNELIITQKQQIKEFTSKALNSVREPKGNPLTWQTSESKPTAPALPMSASAAQTLDAKPNLMAHEQSFSSHILEPIEELSEEEKGRETEQKLNNKIHLRKALKSNPCLTKEIRRVLEQSLLEKLETLGINADIRGIPSDHFGRVLRMVESARHEQERHIPNIQQIREFLEHEVSCKIEERTLLSLDKCSASQMDTLSTGEIPKAKQLPPRSRPLIRQRPVFTDRTSAPKIKKNIVEDHFPRKSSTITTPPFSSEEELDADDFLQACASPDLLPVQSSKSNKSGFGKNIVKSDTDWTEGSEIEDSDISPKPTGTSIKTLTEKVEKTVSNHRNVNKPVGGINVAEAFIKKELKEELKCADVDDDDWDISSLEEDKSLGKKTGQEQKEPLPVKNESNSTQVPNAWGAPNLKGPKGEGLQDESSTLKSSLVTVTDWSDSSDV
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAWVLLLSPAAAAADHGGTSHSDGSIGVIVDYGSRVGKEEKVAMELAIDDFYKKTNQRLVLHSRDSQGDPLRARLSAMDLIEKQQVQAIVGLHTWEEVSLVAEVGGQARIPILSLADSTPKWATDRWPFLVQASPSRYLQMNAVAAIVGSWQWRWITVIYEDTDSAATDIIPCLVDALKQVGSEIGYLLALPPFTVNSSSPLSGELEGLKGRQSRVFVLHSSLSMAAHLFETANELGMMEEGYVWIITDRTTNLIHSMNSATISSMQGILGVRSYFSQSGPRFQGFYLRFREKFHSLYPKEDNHEPGIFALQAYDAVWSVALAMETAPSSKKGLIQPFLERIAISDFHGLNSRIQFNRRSLAPQRIFQIINVIGKSYRELGFWFEGSGFSKTTNEKSTYSRQLQVLGQVLWPGGPWSVPRGWSLPTSQKPLRIGVPQHGTFKQFVNVTYDGSHYSVTGFSIEVFNATLEHLKYHLTYELIPYSGNFDSLVEQVHLKFTSLVTTGEKLHSNLSRLSMVVWLFVALVITQSYTANLSTLLTVQQLKPSVKSLKDNNFVVGCSFRSFIPKYLEEVLGIDPKNMKDIRSFEEYPQAFRRGEIAATFMESLYAEVFLAQYCKGFVTVGPTFRVGGLGFVFPKGSTILPDISEAVVKLYEKGEIMYLRNKLVHSQKCLEVEAEDDHSISPDSLWVLFLATGATSTVSLAIYVAGQMQHFQDFMLENIGIWRLISAAMRSWMHHHAQRTQFSGGDLKRTSSLVELGTYRGSHGNV
The following text describes a protein:
Function:
May have a specific function in the mechanism or regulation of T-cell cytolytic activity.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MALTAHLSCLLVLVVAGPAQGLKDALRSQDPGPQPMGLKEVFTLFQIQYNRSYSNPAEHARRLDIFAQNLAKAQRLQEEDLGTAEFGVTPFSDLTEEEFGQLHGHHWGAGKAPSMGIKVGSEESGETVPQSCDWRKKPGVISAIKHQKDCNCCWAMAAVDNVEAQWAIKYHQAVQLSVQQVLDCDRCGNGCNGGFVWDAFLTVLNTSGLASEQDYPYKGTVKTHRCLAKQHRKVAWIQDFLMLQFCEQSIARYLATEGPITVTINAGLLQQYKRGVIRATPATCDPHLVNHSVLLVGFGKSKSVEGRRPRPGHSIPYWILKNSWGPDWGEEGYFRLHRGSNTCGITKYPVTARVDKPVKKHQISCPP
The following text describes a protein:
Function:
Probable protein deacetylase that catalyzes deacetylation of acetylated lysine residues. In vitro, exhibits high activity against artificial HDAC (histone deacetylase) substrates containing acetylated and trifluoroacetylated lysine residues. Is not able to deacetylate acetylated polyamines.
Sequence:
MTRRTAFFFDELCLWHAAGPHALTLPVGGWVQPPAAAGHAESPETKRRLKSLLDVSGLTARLQLRSAPPASDEDLLRVHPAHYLERFKALSDAGGGSLGQDAPIGPGSYEIARLSAGLAIAALDAVLAGEADNAYSLSRPPGHHCLPDQAMGFCFFANIAVAIEAAKARHGVERVAVLDWDVHHGNGTQAIYYRRDDVLSISLHQDGCFPPGYSGAEDIGEDRGRGFNLNVPLLPGGGHDAYMQAMQRIVLPALERFRPQLIVVASGFDANAVDPLARMQLHSDSFRAMTAMVRDAAERHAGGRLVVVHEGGYSEAYVPFCGLAVIEELSGVRSAVRDPLRDFIELQQPNAAFRDFQRQRLEELAAQFGLCPAQPLQAAR
The following text describes a protein:
Function:
Transcriptional activator.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSVFYPIHCTDYLRSAEMTEVIMNTQSMDEIGLSPRKDSYQIFPDPSDFERCCKLKDRLPSIVVEPTEGDVESGELRWPPEEFVVDEDKEGTCDQTKKENEQ
The following text describes a protein:
Function:
Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
Subcellular Localization:
Nucleus.
Domain:
Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression; C-terminal truncated mutants display increased transactivation.
Sequence:
MARRPRHSIYSSDEDDEDIEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQEPSKASQTPVATSFQKNNHLMGFGHASPPSQLSPSGQSSVNSEYPYYHIAEAQNISSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELELLLMSTENELKGQQALPTQNHTCSYPGWHSTSIVDQTRPHGDSAPVSCLGEHHATPSLPADPGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSFLNTSSNHESSGLDAPTLPSTPLIGHKLTPCRDQTVKTQKENSIFRTPAIKRSILESSPRTPTPFKHALAAQEIKYGPLKMLPQTPSHAVEDLQDVIKQESDESGIVAEFQESGPPLLKKIKQEVESPTEKSGNFFCSNHWAENSLSTQLFSQASPVADAPNILTSSVLMTPVSEDEDNVLKAFTVPKNRPLVGPLQPCSGAWEPASCGKTEDQMTASGPARKYVNAFSARTLVM
The following text describes a protein:
Function:
A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Domain:
The leucine-rich hydrophobic amino acid N-terminal region probably helps to anchor the protein to the microsomal membrane.
Sequence:
MLLPGLLLLLLLLAGTRWLWGQWKLRKLHLPPLAPGFLHFLQPNLPIYLLGLTQKLGPIYRIRLGMQDVVVLNSNRTIEEALIQKWVDFAGRPHMLNGKMDLDLSLGDYSLMWKAHKKLSRSALMLGMRDSMEPLIEQLTQEFCERMRAQAGTPVAIHKEFSFLTCSIISCLTFGDKDSTLVQTLHDCVQDLLQAWNHWSIQILTIIPLLRFLPNPGLQKLKQIQESRDHIVKQQLKQHKDSLVAGQWKDMIDYMLQGVEKQRDGKDEERLHEGHVHMSVVDLFIGGTETTATTLSWAVAFLLHHPEIQKRLQEELDLKLGPGSQLLYRNRMQLPLLMATIAEVLRLRPVVPLALPHRATRASSISGYDIPKDMVIIPNIQGANLDEMVWELPSKFWPDRFLEPGKNPRTPSFGCGARVCLGEPLARLELFVVLARLLQAFTLLPPPDGTLPSLQPQPYAGINLPIPPFQVRLQPRNLAPQDQGERP
The following text describes a protein:
Function:
Plays a role in inhibiting the host innate immune response by targeting the mitochondrial-associated innate immune response. Acts by binding to host TOMM70, inhibiting its binding to HSP90AB1 thereby disrupting the interferon activation pathway.
Miscellaneous:
MISCELLANEOUS: The open reading frame (ORF) encoding for this protein overlaps with the N ORF.
Subcellular Localization:
Host cytoplasm. Host mitochondrion.
Sequence:
MDPKISEMHPALRLVDPQIQLAVTRMENAVGRDQNNVGPKVYPIILRLGSPLSLNMARKTLNSLEDKAFQLTPIAVQMTKLATTEELPDEFVVVTVK
The following text describes a protein:
Function:
Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol. Shows a preferential hydrolysis at the sn-3 position of triacylglycerol.
Sequence:
MLRAGLGGAGSRRHFPAAAAAIGGARGWWGGTGPMRPGSRPRAPLKRPCGRGGLRGAEGMKMQLLGLVICLVLGTLRSEALKGKLASLDPETKMNVSEIISHWGFPSEEHFIETEDGYILCLHRIPHGRNGRSEGPKTVVFLQHGLLADASNWVTNLPNSSLGFILADAGFDVWLGNSRGNTWSRKHKTLSIDQDEFWAFSYDEMANYDLPASINFILNKTGQKQVYYVGHSQGTTLGFIAFSQIPELAAKVKMFFALAPVASIQFSTSPLSRLGELPEFLLKDLLGSKEFLPQSMLLKWLSAHFCSHVILKELCGNAVFVVCGFNEKNLNMSRVPVYISHSPAGTSVQNILHWAQFIKYQKFQAFDWGSCARNYFHYNQTYPPPYKVKNMLVPTAVWSGGNDLLADVDDVGILLPQITHLVYNKLIPDWQHLDFIWGLDAPWRLYNEIVNLMRKYL
The following text describes a protein:
Function:
Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDMLNPQFEEIGKEFVNHYFQLFNSGRNELAALYKDISMMSFENDQCRGTSQIIERLNKLPPTVVHKCLSLDIQPTPNNGILILVCGDIIIEENKPLKFCRSFHLFPLPSGGYFIFNDLFRFCIS
The following text describes a protein:
Function:
Plays a continuous role in plant development probably in the structural organization of compartments.
Subcellular Localization:
Plastid, chloroplast stroma. Note=Probably also in other plastids.
Sequence:
MLSSSPTSFTHPFLSSSPPLSPISPPSRTARISPPLVSASCSYTYTEDSPRLHQIPRRLTTVPASLYDVLEVPLGATSQDIKSAYRRLARICHPDVAGTDRTSSSSADEFMKIHAAYCTLSDPEKRSVYDRRMLRRSRPLTVGTSGLGSYVGRNWETDQCW
The following text describes a protein:
Function:
Participates in the later stages of centriole assembly through the interaction with Ana3 leading to the centriole to centrosome conversion in somatic cells.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to the more distal part of the lumen of the centriole. Recruited into zone I during interphase after the formation of the cartwheel at the end of mitosis. The Rcd4 recruitment to the daughter centriole is dependent on Ana3.
Sequence:
MPHKRRNRVHANQRNFTARRVSVAKLSSAPPNVLVESCNGSHADNSSPDSPKAKEGAMTNGKNPEIKLAVPKCNTTVRKQNEAHIISNIKLDMNLNKDSNFIAPQITKKMNFAPNRVVFGVLVPLNVNDSVLVPHNRKPDALKHTSKESESCKAISEPQLADYAEKVDPMIMAVKEPVLHLDWEPGPFDFFGAYRRTYN
The following text describes a protein:
Function:
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
Sequence:
MLDREGYRPNVGIILINNRNEVFWGKRVREHSWQFPQGGIKPGESPETAMYRELYEEVGLLPQHVKIIGRTRDWLRYDVPNNWVRREWRGSYRGQKQIWYLLRLTGRDCDVNLRATRHPEFDGWRWHQYWAPVDEVIDFKRDVYLGALKELSSRFLRGMESYEDFAARQSSDNR
The following text describes a protein:
Function:
Strong inhibitor of lysozyme C.
Subcellular Localization:
Periplasm.
Sequence:
MGRISSGGMMFKAITTVAALVIATSAMAQDDLTISSLAKGETTKAAFNQMVQGHKLPAWVMKGGTYTPAQTVTLGDETYQVMSACKPHDCGSQRIAVMWSEKSNQMTGLFSTIDEKTSQEKLTWLNVNDALSIDGKTVLFAALTGSLENHPDGFNFK
The following text describes a protein:
Function:
Essential component of a cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
Sequence:
MSALLSESDLNDFISPALACVKPTQVSGGKKDNVNMNGEYEVSTEPDQLEKVSITLSDCLACSGCITSSEEILLSSQSHSVFLKNWGKLSQQQDKFLVVSVSPQCRLSLAQYYGLTLEAADLCLMNFFQKHFQCKYMVGTEMGRIISISKTVEKIIAHKKQKENTGADRKPLLSAVCPGFLIYTEKTKPQLVPMLLNVKSPQQITGSLIRATFESLAIARESFYHLSLMPCFDKKLEASRPESLDDGIDCVITPREIVTMLQELNLDFKSFLTEDTSLYGRLSPPGWDPRVHWASNLGGTCGGYAYQYVTAVQRLHPGSQMIVLEGRNSDIVEYRLLHDDRIIAAASELSGFRNIQNLVRKLTSGSGSERKRNITALRKRRTGPKANSREMAAATAATADPYHSDYIEVNACPGACMNGGGLLNGEQNSLKRKQLVQTLNKRHGEELAMVDPLTLGPKLEEAAARPLSLEYVFAPVKQAVEKDLVSVGSTW
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
Miscellaneous:
MISCELLANEOUS: Present with 2181 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSNQALYEKLEQTRTILSVKLAELINMTTIADRNDDDEGSFAQENSELAVATTSVMMVNNQTMQLIKNVQDLLILTRSIKEKWLLNQIPVTEHSKVTRFDEKQIEELLDNCIETFVAEKTT
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MLLASSLAVTLISISSQLAEANIAPGANAAPFSALCRLMQIQSTGAPADEHPGDIAALIAELEAINMSLSGPKWQTKFVKAEESQVNWDDGENKDRDKHPHWKNEWSSWAAARQAIKKGTAVAQKLEQNSFSKIQGLHREIARLKIEQALQKTKKLQESAAAAATTLTEATKTEVDKDLNQAIYGDDSGLGGFGTNGANHAQYKAVTQCDSDGIAQSKATVAYAMMCLCLEAGGATGAKPCEASTKTGNWNGADTDLAAEFQKVKKLCHTTKKATVSADSIRSALDHVHSLIKIVSNAGYLGHYENTGCTGTSNQGLCVRYATKLTDTADDFHSLHFVQKMEEAAKKLQQRQAALDTVRTAHRAVGAELAAAWLLAKEQQVKEQQSQVAASSPSHPSKPATEAVEVQKKECEAIEKDTDCDSKPYCTYQKDSADDKKCKFNATKAEKSGVPVTPTQTGGTENGKTDSDRCTKHTKKEECEAENKNVKAGEKAVCGWIEEKCKDSSFDLNKKFTLMVSAFVALLF
The following text describes a protein:
Function:
Necessary for protein translocation in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MDALDSVVDPLREFSRDSIRLVKRCHKPDRKEFSKVALRTAIGFVVMGFVGFFVKLIFIPINNIIVGSV
The following text describes a protein:
Function:
May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
Subcellular Localization:
Secreted.
Sequence:
MDLQHPSRFITFGVWLFLAGTACIETIGSEDAAKTLHIHRQQQDTVRCSLAQSVALPCLFLLHPSRPPQPPNDTSESPRIKWSRLQPGIGQKEVPVLVARDNVVKVARGYEGRVALPGYPHNRYNATLVLSSARASDSGVYRCEVIFGIDDEQDAVPLEVTGLVFHYRAASNRYALTFPEAVRSCQENSGVIASPEQLQAAFEDGLDNCDAGWLSDRSVRYPIKTPRPGCYGDRNNLPGVRTYGERDLQETYDVYCYTEGPEGDVYYVPDRTPWLGSSHSCLQDGGMLATVGQLYSAWRKGMDQCDPGWLADSSVRYPIRNPRKNCGGEEPGVRTLYQYPNRTGFPNPTRKFGAFCFKALQTTAPTLLGNKQQGPAFMLQEDLRLINTELQSQESGQTKELEFNNALPSTDSLISTTTHGVFQTEGSYPQIPGSSKEIAKEINVLPPKQVLQVSSKEHIQTVTTEPMEGDYLLSFRTETLTSGTIKEIKTTTQKVGQAKSFSDPLRNKSRQPSASRLREEDWSLNIVDREVKSREATWRDFLEQPVADSKEELPGFDYSVDKQTLVNEPRSLPEDDRNSLHISLDGRGSVFQETDALNNIATSAIPETSKPSIYFPKSSQENSISSHQSSLFKEPNQHSKIRLTEDTGYSDQNIHEGLQKNEKRVNDNEENVDSQIHLVYDEMQKTNVDLTTQAFQRSTLHTSEESQSVFNEADGTTGKKTSLNEQKEDKEMDSLTSFATHLDVNDDINKPEQQEFTDIFSNHPTMDPMGNGQLESYYRAMLGVNQISPIDVQDLPQAVTVPGMEGNSLQSTTSSKQKSIWRHPGNMSKNAFVDKKSPNGSYGRTAEMTVNIPSKTEILPTPENIDSFSGDSKERDENNLFLLNSPALPKPSVVTKISDDFYFPTVDHSNTEAKSILRDRTIKLDENEEQYPSFQERQGKERTFSAKLASTFKKIMAQLETKEVISKELNVSDASISDSAFRKHEPAMLNTVHPPDDDSYSPEEKVKTAEMTTQYLINMTSIQNTELEGWRMDKALSKPSFPFTTDMAMNSDNLQKPTHSTERVELIMTTENPRNKNVTSFNLPKHQTSVSALQLSPGDGQNYSEFRNQTKPISPQDSNKTVAADEYLVELVDKTRRLSTAAENKIKLAQQTSNSFPTPNLITASTSFEEDAFGTSLSSTIVQPNTAPTESAFDGLASVLNNNYGEQASPPTVTFGYETGYNGHVSISPSQKEEQSTLDSVIEYPVNTETSEIEEEAVHEKDLGSGLDEDSSLWMIEDHTSTQGEPQPCSHNPCLHMGTCQSNGSTYSCICHKGYSGENCEIDIDECLSNPCQNGGTCIDEINSFLCLCLPSYGGSTCGKDTEGCDHNWHKFQGSCYRYFPQRRPWEEAERDCRRRAGHLTSIHSPEEQTFINSFGRENTWVGLNDRTVEQDFQWTDNTALQYENWKNNQPDNFFSGGEDCVVMVSHEEGKWNDVPCNYNLPYICKKGTVLCNSPPAVKNGYLIGKKREKYSIHSTVRYQCQDGFIQRHIPTIRCHRNGRWDRPRIQCVKPRRHHRARRHHHQHGHHPHKQHHHHKHNHHNHHHHHQHKSHRERRKEDHHQHGNTKDIYYH
The following text describes a protein:
Function:
General regulatory factor (GRF) that contributes to transcriptional activation of a large number of genes, as well as to DNA replication, silencing and telomere structure. Involved in the transcription activation of a subset of ribosomal protein genes. Binds the ARS-elements found in many promoters. Binds to the sequence 5'-TCN(7)ACG-3'. Influences on genome-wide nucleosome occupancy and affects chromatin structure, and probably dynamics. As a component of the global genome repair (GGR) complex, promotes global genome nucleotide excision repair (GG-NER) which removes DNA damage from nontranscribing DNA. Component of the regulatory network controlling mitotic and meiotic cell cycle progression.
Miscellaneous:
MISCELLANEOUS: Present with 4820 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
Contains 2 important clusters of amino acid residues in the C terminus (C-terminal sequence 1 or CS1, residues 624 to 628; and CS2, residues 639 to 662). CS1 specifically participates in transcriptional silencing and/or repression in a context-dependent manner, whereas CS2 is universally required for all functions of ABF1.
Sequence:
MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MSSSADSSETRRFPGGKTVKTPEKSNFSQTCSLLSQYLKEKGNFGDLSLGMNCSLQGKGKPETPSQSTSTTIMTFLPSMGTSSSTEQNASSRNVKSMDLFPQHAGFGPSNPTKNVTKTADFRAPAIKEPQTAQMTIFYAGKVHVFDDFPADKAREIMLLASRSSTQNSGSFTSTSGNEQQNFGILASSASNFPPISSNNNSTEERLHPSAQTSVSDLPIARKVSLRRFLEKRKDRISSKAPYSVGYSSSTPAGERETPFRSKPIESKTWLGLASHYSQQLGFQLS
The following text describes a protein:
Function:
IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.
Sequence:
MEEWIKGLLAVPFVLHSQPTGVFESRNGTIGEMAEIAHRRYAEIMQDVEDMIDDHIAHQKVGLGGQSKLKLLVPSIGTFFTRLPLADAFRYQDRKRFISSRRFVPPSFNDIRVILNTAQLMGVTSAGSVDLATFDGDVTLYDDGKSLEPTNPVIERIISRSDNFPLHGQILMAIDLMSHNTKIGIVTAAGYSEAEKYYGRLHGLLEAIKVSTILTPEQKQNLIVMGKSTFVQLFSKVSFLSSLSITIRLTFALTHLHTRLFQNSRPAPSNTTSGGESNFLFTYDSNSPHLLTHHHRRSWILPSMSTWTQPNITALLDLAESSLRECVTNLALPATILRKERAVGIIPQEPGFKFAREHLEETVLVVQKKLEMSDVGRSLPFCAFNGGNDVFVDIGDKSWGVLVCQKFFGGNVEDESRWIKGERTLHVGDQFLSAGSNDFKARVVGTTAWIASPRETVELLDELGGFIQKK
The following text describes a protein:
Function:
Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
Subcellular Localization:
Preautophagosomal structure membrane; Multi-pass membrane protein.
Sequence:
MFGGQIGATTLHNLKQKLLGESSYTPFSDNVNPEIELSDYQRAPSPGSESPSGLLNGESFKVEPIADLDLFFERLYSYYCEKGLWCIIIKWIVELLSLAFTICFSGFFILFVDWDGLRKAKCGMDAVESGIKPCDLAKEALHEHPLTPLTTFKVVIFGYLGITFVYWIFCFLRFFVQLKDTLDIRQFYINSLGVTDNEMQTMPWASILEKVVQIQETRQLCVVKDLSAHDIVMRLMRKENYLIGMLNKGVLAFPISSWVPGAGPTIKKGPDGTRYCLMLTKTLEWTLNWCILHSMFDRNFCIRKDFVRDRNTLKKRLMVVGIAMLLLSPFLVVFMLVYLFLTHAEQFYKHPSTASSRRWSNLSKWIFREFNEVNHLFKHRINSSVTHASDYLKQFPSPILSIIAKFISFVSGGFAAILIIIAFVDESLLEGHIFGRNLFWYAAVFGAITAIGRALVSDELLVLDPHGTMSLTVQHTHYMPKKWRGKENTEFVRVEFETLFQYTGKLLLEEMASIFLTPFLLIFVVPKRVDEILQFIEDFTIDVEGVGHVCSFSLFDFQKHGNSKYASPHNSSSAYRSSQGKMEKSFLSFQTSYPSWEPSADGKQFLSTLEAFKERKFQEQGIRPSYISPNQLPQWAPTCPAQGDPNSYFSRDTGLNVSKSAYQRDCMWFIDLVQNNHPYILDWYYTSFQHHGPRDVESAPIEDSMANVWDPPDLGRELVPYDENWGSFFEDRIGSNLKASTSAPLSRGSVLHHHYSGNVGPAGKSHWWARGGGVSRVMGPGPGPQTSFLEPPNFIQEDYDYHDNYSNRSFEQQPFDWRGSKSNVLSKTFYMGDIEGGKSDLPFDDIYERRSQSPPRTRRSSL
The following text describes a protein:
Function:
Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis (By similarity).
Sequence:
MADSATLDATTVQVLQDLANRLRVHSIRATCASGSGHPTSCCSAAEIVSVLFFHTMRYRQTEPAHPDNDRFVLSKGHAAPLLYAAWVEAGSISEPDLLNLRTIHCDLEGHPTPRLSFVDVATGSLGQGLGAACGMAYTGKYLDKASYRVFCLLGDGESSEGSVWEALAFASHYGLDNLVAVFDVNRLGQSGVAPLKHCTDIYRNRCEAFGWNTYLVDGHDVEALCQAFSQAAQGKNKPTAIIAKTYKGRGIPNVEDAENWHGKPLPKERADEIIRLIKSQIKTNRNLLPKPPVEGSPPVSITNIKMTCLPDYKVGDKVATQKAYGLALAKLGLANERVVVLDGDPKNSTFFEIFKKEHPERFIECFAAEQNMVSVALGCATRGRTITFVTTLGAFLTRAFDQIRMGAISQSNINLIGSHCGVSVGEDGPSQMALEDLAMFRSIPNCTVFLPSDAVSTEHAVYLAANSEGMCFIRTNRSETAVIYTPQEHFEIGRAKVIRHSNNDKVTVIGAGVTLHEALAAADALSQQDISICVIDPFTIKPLDAATIISCAKATDGRVVTVEDHYQEGGIGEAVCAAVSGEPAIHVHQLSVSGVSERNRKPSELLSIFGVSARHIIAAVKYTLMN
The following text describes a protein:
Function:
Probable planar cell polarity effector involved in cilium biogenesis. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate protein and membrane transport to the cilium. May regulate the morphogenesis of hair follicles which depends on functional primary cilia. Binds phosphatidylinositol 3-phosphate with highest affinity, followed by phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MGDDGPGSTVHLLCLAASSGVPLFCRSSSGGAPSRQQLPFSVIGSLNGVHMFGQNLDVQLNSARTEDTTVVWKNFHDSITLIALSSEEGTSELKLERMLHMVFGAMVLIVGLEELTNIRNVERLKKELRASYCLIDSFLGNSELIGDLTQCVDCVIPPEGSVMQETLSGFAEATGTAFVSLLVSGRVVAATDGWWRLGMPEAVLLPWLVGSLPPQAARDYPVYLPHGSPTVPHRLLTLTLLRGLELCLLCGPRPPLGELDPQLLERWWQPLLEPLRACLPLGPRALPDGFPLHSDILGLLLLHLELRRCLFTVEPSKDKEPSPEQRRRLLRNFYTLVATTHFPPEPGPAEKQEDTVHPAQTPRACYLVLGPGMGWQLVAVQLGLRLLLLMLSPQTPTHGLRSLATHTLQALTPLL
The following text describes a protein:
Function:
The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization; Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
Subcellular Localization:
Cell membrane, sarcolemma. Nucleus, nucleoplasm. Postsynaptic cell membrane. Secreted, extracellular space.
Sequence:
MPTPLLLKPLDQLAAFIGQAFLFKVPDDTFYPTYNAESSSNLRLTMYTKNGGEISKTSWIQFEPSSRNVYGFPLPGNKGVFKFLVSATNQRGQSAKDFMEVDIKENTGQYNHEFVINTDFNLVSFMADVLVRFEFVSRVGRYIANEDISSVWLKSFNQDTREVTISLNTVPYAPCNKPKLKRLLTRFVSDTGAVNQNFQTAMSEKFPVSSVKMNYLGICLEEENADNVGFDWGWLRHVLPLFMLIGVVGIPVGISCIIGKIARKRRLARQGRRKREENGMGFTFHTVHFNNRYPSMLSMSNNSKEDEGNDELNLNSNLRVNIPNGSPPAATHLAVLNANQKQQNTLNAEKEKNTPKSKVVYMGKSDLNIPVYFTQPKLEEDNPLIDINFAELAESISSKLKGFGKSVMNVAGVAENDVNTMQETKTVIEGDLVAFESEIRIPAPGEEPSGSMAGIQRLMSTGRSRRMAKRSQSEVRLNEHAFYEENLDYKSIKFVGLPNIKGTLMSPVKSRMPSRRLSMPHIGFGDHGQDLGLVLETPTKPAKPLKSALKKNSPVSRLSNLTDSIIGMAANGDSIGQYTGYIEQLSQNARQEFGSNLETGYHTEATPNIEAVPHESPKEPATYYRPKEAGIDPYGAHAHSDVCEEYEYEESSVEDPEELEVMDYTTWRLKQIRKAERQEKRIPHEEYDEADPDDPEYEDYTNPYHYTNGPLRPPVRSQSSYGLLERSKSPSEFPSDWTSDYEKENRYKQQPPETNHHNHVTQSMPGGLDQKGHQGIMGNHTGSKVDNSDGATSKENKSFLGSMFFREKPSVDQNVNQATSDGDGSVVGFLKTSLTGFLGPSSSEGTSSSAASRWFK