lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Serine/threonine-protein kinase which phosphorylates RAB proteins involved in intracellular trafficking. Phosphorylates RAB7A; this activity is dependent on protein kinase C (PKC) activation. Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm.
Sequence:
ITGVLQLQPRMYWCVGTEASAVGQDHIMSVDMGSKQSTLGNVSIDQSPMIESIQAAYKKGKASKVQELVKVFEESVSHLEKCQLLSITAAYGDLEAVRYLLKEKFVELPTEPNDDNPAVVAAYFGHMDVVKELLDSLLGPCSYQRLLNWMLAIACQQGHLDVVKLLVLTYSADPESYAVRKNEFPVIIRLPLYAAIKSGNEDIAIFLIRHGAFFCSYILMDSPDLSKHLLRKYFIEASVSRTGSPTKAALHVKWSHLKLPWVDLDWLIDISCQITELDLSANCLTSLPSVIPWGLINLRKLNLSDNQLVELPSVQSSDEIICTRLLEIDISSNKLLHLPPGFLHLSKLQKLTATKNYLEKLFEEENATNWIGLRKLQELDLSDNKLTELPTVFLHSFKSLNCLNVSRNKLKIFPDPWACPLKCCKAAKNLLEYLPDKIAVFWKNHLKELDFSENALKDVPLGLFQLDTLMSLKLLGNQLISLPSQDKWTCKQLKYLDLSKNQLGKNEDGLKTRRISFFNTKNRQRSCTESGLEFPAFLSESLEVLCLNDNQIDMIPQSVCLLKGLSELYLGNNPGLRELPPELGQLANLWQLDIEELNISNVPAEIQKEGPKTILAYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQTGRPPQMMHSDATIRTSKWELQKPPGSKAKVDSVEFNVWDIGGPASMSTVNQCFFTDKALYVVVWNLALGEEAVANLQFWLLNIEAKAPNSVVLVVGTHLDLIETKFRVERIATLRAYVLALCRSPSGSRATGFPDITFKHLHELSCKSLEGQEGLRQLIFHVTCNMKDTGSTIGSQKLAGRLIPRSYLSLQEAVIAEQQRRNQADDVQYLTDKQIEQIIEQTPGNDINDYEDLQSAISFLIETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKSSKSVAKNGVIRAEDLRMLLVGTGFTEQTEEQYFQFLAKFEIALPVANDSYLLPHLLPAKPGLDTHGLRHQAANTIQRVFKMSFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKNRNRKVTIYSFMGSQRNRCSTFRVKRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGIKIICQSEVRDFSAMAFITDHINSLIDQWFPALTATESDGTLLMEQYVPCPICESSRTLQNDLNEKIEDVQYFDMEDCVLTAIEQDFITCPSHSDIPVPLQELVPELFMTDFPARLFLENSKLECSENENNVLGQGGSGTIIYQAQYHGKPVAVKRFQLKKFKNFANATADTMLKHLRAMDAMKNFSEFRQEASMLHSLQHPCIVSLIGISIHPLCFALELAPLGSLTTVLSEKSKGSSFMPLGHMLTQKIAYQIVSGLAYLHKKNIIFCDLKSDNILVWSLDVKEHMNIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPVLGHHQLQIAKKLSKGIRPVLGQPEEVQFHRLQALMTECWDTKPEKRPLAVSVVSQMKDPTFATFMYMLHCGKQTSFFSSPGQEYTVVFWDGKEESRNYTVVNTEKGLIEVQRMSCLGMKLSCQLKIQSALWTATEDQKIYIYSLKGMCPLNAPQNALDTPAVVTCFLAVPVMKKNSYLVLAGMSDGLVAVFPVIQGIPDKNCSYLCSHTANRSKFNITDDDPRQNPYPVRTMEIANSGSEVWYSNGPGILIIDCATLEINRRLDPYSPPSMITSMVVNSECHGEEVVWCLDDKDNSVVMFFSATYQLCARYFCGDCSPLRDTFPVEQPILGLSTADMASQKHPVGDCIADVSIIFSEELGTQILNHQNSLTDYCSMSSYSSSPSNRINRSFSSLPNLPMSSSTVPFPTDYEDSDKFHEPNFCSDGSEKDGPLLNSEASTHLQAVKILSVKDLIWIPRQGGDVIVIGLEKESGTQRGRVIAVLKARELAPYGTLVEAAVVAKDTVVCCFEQENMEWCLAVWRGWGAREFDTFYQSYEELGRLEAGMRKRR
The following text describes a protein:
Function:
Functions in xyloglucan synthesis by adding side chains to the xylosylated glucan backbone. Involved in the galactosylation of hemicellulose xyloglucan.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MRPKNYSQMEKPISITTGKFRTNNNNNHNNVWFVVPLFFILCFVLLCFDYSALFTDTDETAFSIPDVTQKSTSSEFTKDDNFSRFPDDPSPDSSCSGRYIYVHELPYRFNGDLLDNCFKITRGTEKDICPYIENYGFGPVIKNYENVLLKQSWFTTNQFMLEVIFHNKMINYRCLTNDSSLASAVFVPFYAGLDMSRYLWGFNITVRDSSSHELMDWLVVQKEWGRMSGRDHFLVSGRIAWDFRRQTDNESDWGSKLRFLPESRNMSMLSIESSSWKNDYAIPYPTCFHPRSVDEIVEWQELMRSRKREYLFTFAGAPRPEYKDSVRGKIIDECLESKKQCYLLDCNYGNVNCDNPVNVMKVFRNSVFCLQPPGDSYTRRSMFDSILAGCIPVFFHPGTAYAQYKWHLPKNHSSYSVYLPVKDVKEWNIKIKERLIEIPEERVVRLREEVIRLIPKVVYADPKYGSDGSEDAFELAVKGMLERIEEVREMMRQGKDGSDGFDDRDDYKYTFSPYEEPQVLA
The following text describes a protein:
Function:
Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
Sequence:
METKLTTVGVIGGGQLAWMMAQEAPRLGLKLAVQTPGESDPAVALADKVVLTAIADGEGTRELAEHCGVITFENEFVDLPSLEKLAQQGITFHPRLDALAPLLDKWEQRHFLQNLGLPVPDFWALESLPAQLPDFPWVLKARRHGYDGQGTQIINSPADLPDLSKAPPGSWMVESFVPYERELAVIGVRNARGEMEIYPVVETKQIDQVCRWVVAPAPIDAAIAATAQDYCRRILNHLDYVGILAIEFFLLPASTQTPTPEQRLLVNELAPRTHNSGHFSLDACHTSQFALQLQAVTGQTLGSSALRCGQAVMVNLLGYEVSTGDYQQQLDKLAALPHSHVHWYGKGDCRPGRKLGHVTLLNPDVESEPSTAWAEDLVKQVEAIWYPD
The following text describes a protein:
Function:
Required for assembly and stability of the aminoacyl-tRNA synthase complex.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
MYELKTLLPQFDIKLPTCMYPLKNVSLAADSLASGSSTSASTSASTSSCKLEANRIDRTGRNAATCALDLDSLGRQIQRLLKDDTASVAARQEKVLKQLEELKAQLGQIRAGLGVCGKTFQHTTAFQNGGLKEVPLQDVVINGHPNFIPYALLALKNAWRNLYTIDVKTFTHSTMADIGPAAREFEANLAKVPVNPALPKISVTLIWKNCEHTEMISSPTMYVPIYGEVNIIRYLGRVGPAEYRYEGSPLCNEIDLVLDICYQLLRCNTHKTQVAMVRLLDKRLQKQQYFGGSQMSVADVGVYSSLIRMPAVTEKDLTPALVAWRKRAKLVVQI
The following text describes a protein:
Function:
May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8.
Subcellular Localization:
Cytoplasm, perinuclear region. Lysosome. Nucleus.
Sequence:
MVDQLAFTEINAQRIAVVENCFGTSGQPLSTPGRVLVGEGILTKECRKKPKPRTFFLFSDILVYGNIVINKVRYNTQRIIPLEDVTVEILPDSIDMRNRWMIKTSKKSFVVSAASYSERKEWICHIEECIHQLLQKTGRQPSKEHAAPWIPDKATDICMRCTQTNFTLVNRRHHCRKCGFVVCHECSKYKFLIPTIKSKPVRVCSLCYKKLVSEKVAIEEEVKRHERQFHDAVPEYDPSSEDSDEDAERQGAWPLNEDFYSSSWSAFHT
The following text describes a protein:
Function:
Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein.
Miscellaneous:
MISCELLANEOUS: There are 2 forms of 81 kDa and 89 kDa detected in brain by an antibody raised against a C-terminal peptide arguing for alternative N-terminal sequences.
Subcellular Localization:
Cell projection, dendritic spine membrane; Peripheral membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Nucleus. Note=Enriched at the cytoplasmic insertion of the slit diaphragm into the foot process of podocytes and associated with polyribosomes in dendrites.
Sequence:
MLDGPLFSEGPDSPRELQDEESGSCLWVQKSKLLVIEVKTISCHYSRRAASRQSMDIQASYWARGPQNRTCRLRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGGARRSPLGQPRPELRNALRAAQPTGFPVFSRPERFGQVGRAPRPSALPQGDPGVAWAGPWGGRRPGPPSYEAHLLLRGAAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPELSRAPTSSAPVPATTRTEGGRTKKRLDPRIYRDVLGAWGLRQGRGLLGGAPGCAAARARPESCKGAVEKSSGLAAAGLNSGGDGHSQAKTTGPVTEVALSGSTISSPPRPVPRSRQHLRGSRKGKEGSEEMWLPTCWLSSPKKPPVRHSQTLPRPWAPGGTGWKESLGQREGTEHETLEVWKVTRRAHTLPRSSRGPAGREGIFVIDATCVVIKSQYVPTPRTQQRQLAPSGESCIVSDSLRQPKPCLEEEGKGAAANPSVCQKRLLSSRVLNPPSEGREFEAEGRQQGDSSLEERSSSGLGFPVGEVNPRDAPTHPGSPEHSTLGPAAPGCAGSVKGPEAAGVPRRAGGGWARTPGPYAGALREAVSRIRRHTAPDSDSDEAEDLSAHSGSSDGSDTDAPGASWRNERTLPAVGNTRPREGGKTAELGDSIGEILDVISQTEEGLVREDTRKTPQGKRE
The following text describes a protein:
Function:
May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17 (By similarity). Is a negative regulator of PAX6 expression (By similarity).
Sequence:
MASGVGAACEELPPDGTCDECEPDEAPGAEEVCRDCGFCYCRRHADAHRQKFLSHRLAAYVHGAQAWTPPASGDDALPEDVEAKGEAEGEVESEVGEEESESEVDSESEEESETEEDSEDESDEESEEDSEEEMEDEQESEAEEDNQEGESEAEGETEAESEFDPEIEMEAERVAKRKCPDHGLDLSTYCQEDRQLICVLCPVIGAHRGHQLSTLDEAFEELRSKDSGGLKAAMIELVERLKFKSSDPKVTRDQMKVFIQQEFKKVQKVIADEEQKALHLVDIQEAMATAHVTEILADIQSHMDRLMTQMAQAKEQLDTSNESAEPKAEGDEEGPSGASEEEDT
The following text describes a protein:
Function:
Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient. Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Sequence:
EILTLAFARSVFVEFISTLIFVFIGLGSALKWPSALPSILQISLAFGLAIGTLVQAFGHISGAHINPAVTIAFFVGNQISFLRTLFYVIAQLVGAIAGAGILYGVTPVNTRGNLAINSLNNNTTPGQALVVEIILTFQLAACIFASTDNRRNSSVGSPALSIGLSVAVGHLVGIYFTGCSMNPARSFGPAVIVRRFSPAHWVFWVGPILGACLAALLYFYILVPYCMNMSDRVAIVKGTYESEEEWEEQREERKKSMELTPP
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. Required for sperm flagella assembly. May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Nucleus.
Sequence:
MHPTRHKQQQLKQNALSRAVESNRLNANYQKDLNQIERNCLEKWTKQAAEQAIRERENDQQRIALKQEAQRRQWLIEEQEQTRRLQEANRQKINEEKLRQQLRESNQEMRELESKLRAAYVAKGIAAQLAEAELRKKAERLQARKEMDEMQRLKDENIAYMQQKQASEENEKRILRSALQQQMHDGRLEKKCLYEEFLMEKTYLDAVVKKIQDEHLEAVQRKLQQQRCTRQEMEHFQEAKETWKARQLLLDEEENERIRKYVQEKDMLKQMEQTQKEEIDQKRMQLNEAMKATLEKEINEQRNREEMLQELYMAERNEKEEIQRQQQLEEQIRKRIAIRLDLEKQLSENNCLRELQAEEEKRFQEQQIQAWAERDRIDIMSNEKRRRKMMEYRRAVHELLEERRKIRPEEVKSLMEQEESQNQAENRRQQILEVRKDKAAEGACSGTARVLSSRRIA
The following text describes a protein:
Function:
Component of the transport system for branched-chain amino acids (leucine, isoleucine and valine), which is coupled to a proton motive force (Potential). Contributes to NaCl tolerance.
Miscellaneous:
MISCELLANEOUS: In Caenorhabditis elegans-killing model mutant strain is attenuated in virulence.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNKNTWVIGFTLFAMFFGAGNLIFPPNLGLDSGQFFWPAILAFVLTGIGLPLLGVIVGALDKEGYIGALNKISPKFSILFLIIIYLTIGPLFAIPRTASTSFEMTITPIIHSNSSIALFIFTIIYFIVVLYICLNPSKLIDRIGSLLTPLLLITILAMIIKGYLDFSGNSAGKGNEALYHSNFSSFAEGFTQGYLTMDAIAAIAFSMIVVNAVKLTGITKTNQIFKQTLTAGLIAAVALIFIYISLGYIGNHMPVSDMTLDQLKSKDRNIGTYLLTTMASTGFGSFGKYLLGIIVALACLTTACGLIVAVSEYFHRIVPKVSYKAFVLVFILMSFIIANQGLNAVISMSIPVLSIVYPVAITVVLLILIAKFIPTKRISQQIPVIIVFILSIFSVISKLGWLKINFIESLPLRAYSLEWFPVAIIATILGYLVGIFVKQDPIKYQQE
The following text describes a protein:
Function:
Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity. Capable of producing kinin potentiating peptides.
Sequence:
MASSGPARLLLLLVLLAGTARASLYFRSGQSCYRPLREDQLFKLGRRTYPRPHEYLSPLDLPKEWDWRNVDGINYVSVTRNQHIPQYCGSCWAHGSTSAMADRINIKRKGAWPSTLLSVQQVIDCGQAGSCEGGNDLQVWEYAHEHGIPDETCNNYQAKDQECDKFNQCGTCTEFKECHPIQNYTIWKVSDYGSLSGREKMMAEIYKNGPISCGIMATEKMANYTGGIYAEYHDTAFINHIVSVAGWGVSNGIEYWIVRNSWGEPWGERGWMRIVTSTYKDGKAEPISKMLTEPLHTRFWKGFFHKWSGMFHFSSGRCSKLVHQDEVGLAVSFKKQKANSHW
The following text describes a protein:
Function:
Cell autonomous antagonist of the canonical Wnt signaling pathway.
Subcellular Localization:
Cell membrane. Cytoplasm.
Sequence:
MANNLVKWWKTKFLNGYKQFSVECGDGKVSDTEELLGRLGSEVDGNERLRSTTPPLPSQDETVPTPTPDDASNTPKKQPQHHLNFEEFSCDVSVEGGEKSKSGQERQEFSFTLYDFDGYGKITKDDIAGLVTTIYEALGSSVKVPHYGSKTIKVKLTVSPDQRKHVSATIINQKDNNEEKTQETSIRYKRDLNVTIRQGINEKRKHGRRQSKPKTPNKKHQCCNKHEEEDQENPFVSDDSSDACSRISGNLTSDEEEGECSDNERHKPKKHQKKCHRSTSPRYTIPNLFIKDANICNENNCSKKTPKKRSGSLQRQELLEIIQANMDKNNLGFQTPRKHSNHVSTQTRQLEGPHKSQSKSPKVSPSPLQYLANIVDPTHFYVDLASLQNTTQLPQTHCQYDKLIDAVMCVSNKKISLNKQKCRKHRVRNDLADIRYQFLQYPMTNDENKLNKPNKRTPKKSVSDVKKSPHVVTGHTSSPHHLRHKNRQEDQARAMAQVVRWLEQEFSSNLNTKEKAKGNHFHSTKEKTTSAPSSPGSGVERHEHHHVHEHIHHHYHHYQETPLVV
The following text describes a protein:
Function:
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
Sequence:
MAISLTEEDFVVKVFDYKNDKEWSFRGDRPAIIDFYANWCGPCKMLSPIFEKLSKKYENSIDFYKVDTDKEQDISSAIGVQSLPTILFIPVDGKPKVSVGFLQEDAFENIIKDFFGF
The following text describes a protein:
Function:
Required for epithelial tube development and shaping. Involved in the morphogenesis and function of the three unicellular tubes of the excretory system, the canal cell, the duct cell and the pore cell. Also plays a role in cuticle development, alae formation and shaping of the vulval lumen. Required for larval development.
Subcellular Localization:
[Isoform b]: Apical cell membrane; Peripheral membrane protein; Lumenal side. Secreted, extracellular space. Secreted. Note=Localizes to fibrils in the vulval luminal space.
Domain:
[Isoform b]: The ZP domain is required for localization at the apical cell membrane, secretion and excretory tube and vulval lumen expansion.
Sequence:
MRHPLISLLLLIAFYSTSSEAFVPKCNSFYVRWPRVRLNFKAVAEARLSLKGCQSACSLGEDPVSPGKQLECAAVNHQASPDGFSHLCAVFQPHQLQNVDGYVEADDRFTFYWKYCLPSTRKCSGEYAFTYLSDRYMDQKSVIKWTTKANLEECLSDCLDEKSFECRSISFNRTDGGCHMSKDSQISRPEAIRLNNNPNYRIDYYENNCYNLSESFTFKHECRDNGISVSVKSRLPYTGAIYGLYDFFTCRTEPKEATEFDHFFPYQTVSKNCSDSIKYKGNEMVLEVVLSTDGIEPLYFITPEDLTYQAKCPISGVKAKDPANTKSSAHLDNRNKAMEASAHALFELLSKTGDDEALQNTFPLPLTTTTEVIRQVTTTTKKPSTTTSTKKLTTTTTTTPKPSQKPTTTTTKSPVVITTTTKTSPKPTTSPSTTTSTTTSTTIPPSTTTRKPANPRRSTIMSATSKVAIIVGKDSSFARARLFTTKHPSTQKIDVPTTTVQTSTTVPTTPSKTTATTTTTPKPTTTETATTSSSTTTVTTQKPTTVTSTTTLPSTTASTTTKTTTSTPTSPQTTTTHVGAPASSVASVAHDGSTLAGKPKVPVIFDIFHNGQPVEAVVVGTKISLSFRPHYPIPPEYVDVRGCQVEPIDPKYEWEHEPLFIIRDGCPADGVGLVCPPTHSEFGAKVSVEAFRYQTTGQVQYSCLVRICPFAPCPKNTCDDVEGCDSSYMHRYRRELSLEDIKKALEANPELASQFGISPSAFARNPSKSKNFTSVVEEQQRIALGGDYLVRRRLIVVNSEDQLRYYVRTGNI
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Subcellular Localization:
Nucleus.
Sequence:
LVSFSEQTMVLIGGNGMQSVDVTFTLHSVVGGPPTHIFVKDGAVADHHEYEMNSHLTVLINLGMGLQECFKNNLKVEVEWDQQKRLWSLSWADIGRSLIYIKQMNNWMSTIAKEWRSQSHRPNNSPWVKNANCTSAVAKKIVTLAIVNPSALNKCYPGFSSMVYGETMLDQMEVIVDKLRLTKDDVFGDLGSGVGQLVAFVAAAARCRCFGIEINPQPARIANKLKEQFEGKRISEERTTTERVVDENGVTHFVPISRTLTARQLSKSPVDLFLDEYKLPLVKDPVSWSNGSGLQFVVFTVNHNKRKEIVKRGLTQFKSLPKDLVDALSKKHREMDLGDMQKMWWDKEYYPAILVAKGSKEVSGVVTVKNASLLAVTLTGERECEELIDDIAAEKRTWESLNIPNISTSLTNLCLYQVAGDHSDAEEAVEEEDKDDDERIIESSRKRRAADGVKEKRVKKRRESRSETKEGNDEEDKENRMA
The following text describes a protein:
Function:
Transcription factor that is essential for the generation of the circadian clock oscillation. Binds to specific sites on CCA1 promoter leading to CCA1 activation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MGEEAPEEYELGGGEDERVMEWETGLPGADELTPLSQPLVPAGLAAAFRIPPEPGRTLLDVHRASAATVSRLRRASSSSSSSFPAFASKGAGTGADEAESGGGADGGNGNTNNSSSKRARLVWTPQLHKRFVEVVAHLGMKNAVPKTIMQLMNVEGLTRENVASHLQKYRLYVKRMQGLSNEGPSPSDHIFASTPVPHASLHDQVPSPYHPHPHHHSYNNAAYAATVSSYHHYHHANH
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
The EIID domain, with its homologous EIIC domain, forms the PTS system translocation channel and contains part of its specific substrate-binding site.
Sequence:
MGSEISKKDITRLGFRSSLLQASFNYERMQAGGFTWAMLPILKKIYKDDKPGLSAAMKDNLEFINTHPNLVGFLMGLLISMEEKGENRDTIKGLKVALFGPIAGIGDAIFWFTLLPIMAGICSSFASQGNLLGPILFFAVYLLIFFLRVGWTHVGYSVGVKAIDKVRENSQMIARSATILGITVIGGLIASYVHINVVTSFAIDNTHSVALQQDFFDKVFPNILPMAYTLLMYYFLRVKKAHPVLLIGVTFVLSIVCSAFGIL
The following text describes a protein:
Function:
Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MASSARWLLGKAGAASHPNTIRIRSRLFSTTANDTSNAPSPQTPHATQSPYVSGPTTHFGYESVSVADKEQKVREVFEKCADNYDVMNDFMSAGLHRYWKDELLKMTGVGPMAKAVRRRASLNYAKGIEMETNESGEDGDAKSIFSILDVAGGTGDVAFRFIDSANCEERAKSSGTDEISVTVCDINPEMLRVGEARARKKYGSALLDESKALSFVEGNAQYLPFEDDSFDVYTIAFGLRNVTDVDMALRDALRVLKPGGRFLCLEFSHVTNIPLAKLYDLYSFNVIPTLGEAVANDRDSYQYLVESIRKFCTQEELVERMKVAGFEGVKYTNMTSGIVAVHEGWKPL
The following text describes a protein:
Function:
Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine.
Subcellular Localization:
Secreted.
Sequence:
MVKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLVSHNVYMLSTVLYPNWGQYKRADLIGQSSYIKNNDVVIFNEAFDNGASDKLLSNVKKEYPYQTPVLGRSQSGWDKTEGSYSSTVAEDGGVAIVSKYPIKEKIQHVFKSGCGFDNDSNKGFVYTKIEKNGKNVHVIGTHTQSEDSRCGAGHDRKIRAEQMKEISDFVKKKNIPKDETVYIGGDLNVNKGTPEFKDMLKNLNVNDVLYAGHNSTWDPQSNSIAKYNYPNGKPEHLDYIFTDKDHKQPKQLVNEVVTEKPKPWDVYAFPYYYVYNDFSDHYPIKAYSK
The following text describes a protein:
Function:
eIF4E1-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (By similarity). Probably plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (By similarity). Acts as a binding platform for multiple RNA-binding proteins. Required for the formation of P-bodies (By similarity).
Subcellular Localization:
Cytoplasm, P-body. Cytoplasm. Nucleus. Note=Mainly localizes to processing bodies (P-bodies). Present at low level in other parts of the cytoplasm and in the nucleus.
Domain:
The YXXXXLphi motif mediates interaction with eIF4E1.
Sequence:
MDTSKISARYSKVDLLALRYEGKSRQRPQCSTRLELQTLGFWKINLNTAALTVSSAYSNQNKNRLSPEADNSSLICSNSSSISSRRAMRNRERANNYYQRFVPTDSLLISGEDKDKDALSHGQPYKLNIIDHRSISSSHLMPAFAKRRFVISKGSNSEESNEGINTCASKGKAASSPSRKGSELDTAETCLNFVQPDHDQCMSSSPTFSTSRQERRIGSGRLLPRSDNWDYKNEKTVEASIENEKETSPNGSGSTSSLNQHNQSQHRSRTFSGRLVERVPEVTDRRFQYDSKKSFDRQGINNRRISGKEPFSTQSRSKRGNSYLIHEEPEWFSAGPKSQLETIDLHGFEDLEKNEERSVTEDKNNQIQQLDKNLDAQASKDEASMRNSNDSLNFREVIPSDEKKHTDENVVTSIQNSTDLGHPNKNKPIQMQPSQNPESEFNFDAFLNMHPLDNSVLSNDETGKSDSKGTSRFSRWFRQKEAANNNEFPGFRESHAQEKRGIPSVKDLEAQMIKVDMRTDLINPIAGSLCQTVQMEKPIARDTEAFKKLLQQLGSQARQHHPCNDDCRTINLSNIANHVHLESKLHQKINDGHLQQPELSVNVPTMPTSSHVFLQKRLEIQHLIQRLHCGDVSHDFLEKELDNPSTPAATKDVIATVLNEYSHSKRNPVVTGDPNIFTQQSFLQPQSVHQHYSQELHSQNTANHTINQLISHGNSPTPLAFTPTSVLRKMTADKDTQSPSTYCQNPQYHVHQQNAKQVGTRENVLEPQLTATMAVQPRMILGGGNFAIGQNNQHLSPNMSQSRNQQVLKWTSGNMQMVHGKTFGRPILKGGLNSMPHSNSALPFTAHKIEMQPIHQPHLQQQQHRFKAVQSVESNLNTESVHQNITSPVGWHQLYMQHQQQHHHTRQQLSQRVIYGEMHRQSNPQMSPPVPGFSDSSDSGNVIKANSLTSPSYQRDERISSPTNQLAQWFSPELLAKASAGKLPLLNVNQALSLEEFERSIQHSSGVVHN
The following text describes a protein:
Function:
K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MDAVTINSFFMIGALLIGISVLLSPVSSKLGIPILLVFLAVGMLAGEDGIGQIAFDNYPVAYLVSNLALAIILLDGGMRTRVASFRVAFWPSVSLATLGVAVTTLLTGLLAMWLFNLSLLQGVLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGTNDPMAVFLTVTLIAVLGSAETNLSAGFLLLSFIQQFGVGALLGLAGGWILWWLINRNQLPEGLYSILAVSGGLMIFALSNALGGSGILSIYLTGLLLGNRPTRSRHAILNVLDGMTWLAQIGMFLVLGLLVTPSELMEIALPGLALAVGMILFARPIAVWIGLAPFKSFTAREKWFVSWVGLRGAVPIILAVFPMMAGLPNAQLYFNLAFFVVMVSLVVQGGTLTKAMSLAKVELPPKPEPISRTGVEIYPTSEWELFIYKLKADKWCIGEPLRNLFMPEGTRIAAVFRDNQLLHPSGSTELCEGDTLCVMAQERDLESLSRLFSEAPEKASLARFFGDFFLDIEAKLQDVALLYGLDLGELEADAKLKDLVLEHLGETPVLGDYFEWHGLQWVVADVVDWKVTKIGLRLPPEEELQEGAE
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MNKETFYTIIKQIRNENQIYKLIFGKDICFKEIKEKCSSLIQEEGCRNKGNSDSRHLLYRCKTCEKTPSSCICCQCFDETKHQGHIYYSYLSMSQYTCDCGNEQYWKKEGFCNKHQHKFNGNIKEIIPKEINYCLKSLAILFQYSISFLMEKDNNGELNMIFKVLCQIDNIPYFHKLFISLLNEKYLFPSDSLLYNKYNYHSLTLFQRYFELSFVHQHLPDSILTFLISFLTNISEMKFDYTSIYDLALASVYFDYSPNNGLESIFSGFIYDKSIAEYSLFKSGRFIQMIDIFINTIKIYSSGIIHDNVLKNVESLLDYINGLINNGIKYQCSLEEFSKVLELICCCSHLFPFYIKTGEHDETDPDHFEYAFLLLYSTLLCFSLIDVFDVDDFYNNHFNFIHQTLMNHVKTYLNNVPLININGIKIHLRKVGINQQVSPLSGINYFYLLILQKLINKNQLDKISISNEDAILLCETSFISLQFIHQFSSNVYVRNNIDVEYHYTFYINLFLPHMLNGDLNISKLMLKYITIDQFIYTLLVIFNVIELEPTNEIIDLNNSHFNTNNFGILLSVLIQMNRTPLIKKVFNDESFIKNIIAHIIMTGESHPTNISELIPFCELNINQLCDELMIKKGVLKEEWLNRINPLYPFLQPELQEQLKINTLFGDKSLKNNRYYFEGLNWNKDLFNCITSSLFWNIIKKGLSNENMIFILMLITDINSEIQNNICSTEDIKSLGIFNEENVTSITEILKNNYTQIKDFEIFIKGINNINVRKLLKFESCTVIPSPVKTTKLTKADLLKKKVLKKMNEKQTTFTLNEHIIEESSLEDQNEDFCVVCQSIKQSPLGRFIYYDPGFAVLIQRKKEGGKSDSETVFTTCKHHIHEECFMELINQYTQCPICKSKFELFLPLSNQISIINENTFNEKYSLIKIAFNNNKNKIFNVLMSCLISTLESLELAQFEKVDIHEDDFDILKSLFIALKSLTINLKSYLDDFIKYSNINSPLYLYIILRLYNQDIQPAYIQQVNNVMSIIAKIKPSLLSHKQINFIKPRLNNMNINGLSDCLSCEDAVNKLSISFEYCIHLIEPIIKNIPMTDEVPFLKTINYIDHATGNDQYTFIPTIPRHIPFIELPKTFEGVLKKYCYSKCDSCDSFISDVLLSRVCLYCGKVICTKRKCLEYHSHQCSCGFNVMLDLYSGAFCLNYRGKTMALLYMKMNMEIVLIQKNYSFQIFC
The following text describes a protein:
Function:
Involved in development of tracheal vasculature. Probably involved in halting cell migration at the end of vascular tube outgrowth. Possesses E3 ubiquitin ligase activity when in complex with Elongin BC complex, Cul2 and Rox1a/Rbx1, and can target sima/Hif1a for ubiquitination. May play a critical role in promoting microtubule stabilization when tubulins are correctly folded by the prefoldin complex. If tubulin is incorrectly folded, may promote its degradation.
Sequence:
MALQIAQNNRDGQQLVGADQGKVEVYVLFANTTYRTLDLYWVCERERENMYLTLKPFEEVRVNTFTTHSWLFRDYYTGERMHVRSQRIFQPIRVRVPKSQQSPDQLVDVRSEVLIHFPMRSLRENCLWLVARWLIRTSNAPRRIIHGYHIPSTLKQQLLSLLTCIESYSRVAGTRRRR
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for the response to N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide. Functions as a pheromone receptor for a male inhibitory pheromone and promotes male-male aggression and suppresses male-male courtship. Also promotes preferentially virgin females courting over mated females.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSPNTWVIEMPTQKTRSHPYPRRISPYRPPVLNRDAFSRDAPPMPARNHDHPVFEDIRTILSVLKASGLMPIYEQVSDYEVGPPTKTNEFYSFFVRGVVHALTIFNVYSLFTPISAQLFFSYRETDNVNQWIELLLCILTYTLTVFVCAHNTTSMLRIMNEILQLDEEVRRQFGANLSQNFGFLVKFLVGITACQAYIIVLKIYAVQGEITPTSYILLAFYGIQNGLTATYIVFASALLRIVYIRFHFINQLLNGYTYGQQHRRKEGGARARRQRGDVNPNVNPALMEHFPEDSLFIYRMHNKLLRIYKGINDCCNLILVSFLGYSFYTVTTNCYNLFVQITGKGMVSPNILQWCFAWLCLHVSLLALLSRSCGLTTTEANATSQILARVYAKSKEYQNIIDKFLTKSIKQEVQFTAYGFFAIDNSTLFKIFSAVTTYLVILIQFKQLEDSKVEDPVPEQT
The following text describes a protein:
Function:
May be involved in the regulation of photosystem II.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane. Note=Associated with the photosystem II complex.
Sequence:
AYGEGANVFGKRKETDQFFEISGDGWSGKL
The following text describes a protein:
Function:
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MPVDTKRVRGPDESQSPLLFVLPSTGKPECPQEGREDGRQRSQADVRPVFARCGLISQAKGSAYIEAGNTKLICSVYGPRETDRKDEVDMKSGRLVCDFRFAPFSCPKRGSWIQGSEEKALSLGLLESLLPAACLHKYPRSQIEVNVVALEHDGSVLAHAVTCASLALADAGIEMYDLVLGCALRQDGPSFLIDPTFAEESGAQSAGSGENQGRVTVALLPSLHQVSGLQSDGEMAEDTLVGAVKACIEGCQRLYPVIQQALARAVRRKAPPTAV