lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis. Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells. Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content. Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid. In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes (By similarity). Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (By similarity). Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity).
Subcellular Localization:
Secreted.
Sequence:
HSDGTFTSELSRLRDSARLQRLLQGLV
The following text describes a protein:
Function:
Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MCNRQPKAVDLPPNYSCPHLLSFQSVEFNTNPTACDDVFCKRIESEKKYNDFLESLFKKYGRDTSDIADEVDLATGEIIVNNGHLEALKTKDDIWDPTFNNLEISASNGYEKKLDSSIGNPGEKAVSPVHIEDFQSPQIYKFKNLSLRDEMVSDCVFADEVPLASLFVENVCNETIPSQSCVRLKINDKTRKVDASALEKKSCLLPNSSGTLTDQRGLDTIKHKSIEQNEILHVISDTLSSPRRRNPLLSSPKTPLRRSFSKSKVRNSNSTKRRNFISLISMISPRPNLSTHHFNLGFQPLSQQTSFSGSSTQNPHSSSTCKKAFCFQCISESKKC
The following text describes a protein:
Function:
Probable ATP-binding RNA helicase.
Miscellaneous:
MISCELLANEOUS: Present with 195 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MAKKTKNNSKSSTPVNDVPTTAGKKKAKGKKGQEPEPEDDKRAKQQSNRAKVTSTASWTGKLPHTILHETCQKRKWNKVEYDMKKIGDKGFIAIAVLSFTDPKTKETLTARMNDPTYDKASGKGLVIPQETPIEARHMASTIALYRIAYNTNLHMMLPPNHRKTWYALDDFRKDNLKTDEKRINKLFDLDPFKTMVEDRKLKAQREKEQVAQNNQAQKEQVARTILSSHGGISSSGKDRQERKVASHKNSHNPSLVRFPKKVWENSIFVDLDESSRQLIETSLKEKIDWQAKKISHKNETIAENREDLKAKLLTLQFRPKHVEEAMLYKDPLSFLLFNLPEDDLPPFFHKKKGDTKNKVEITNLPLSTRMIVERLTEIGVSSDEALLALQQNDMNENEAAGFLTREILPTLNSNTNEPVSETESIECWNQELESLESIYEGCVMDAKEDSHYTLNLIEKLKIKLKVYRTKNYPASLPGIVVSTFDKNYKLPDYIKKQILTRLLHYLQEGNLIGDMLVYHIYEWLKENISKIIDNPGPLIPDSDSKGAINKRNISNGKRSINNSSSRKFTKTTISEDTLSVLREEYTKRIKSSEYKSMQLVREQLPAWKKQKVIIDIINKNEVVLITGETGSGKSTQVVQFILDFLQKEKGDFGKTKIVCTQPRRISAIGLAERVSDERCVTCGEEVGYVIRGVNKTKASTRIKFMTTGVLVRLLQNARTMLENTIVVIDEVHERSIDTDLIVTLMKNLLHRVRGMKIVLMSATVNVDLFKKFFPGLATCHIEGRTFPITDYFLEDILSDLDFKIKREKALSYDDDSVDERNNDDQYLKPRADSKFFTSGQINYDLLCQVVEYVHKRLKAANDNGSIIVFLPGVGEINKCCNLLANKSNEADFMVLPLHSALTPEDQKRVFKKYHGKRKVVVSTNIAETSITIDDCVATIDTGRAKSMFYNPKDNTTKLIESFISKAEVKQRRGRAGRVREGLSYKLFSKNLYENDMISMPIPEIKRIPLESLYLSVKAMGIKDVKAFLSTALDAPPLPALQKAERILTTIGLVDESDKSLTQLGQFISLMPVMDSKHGKLLIYGILFGCTDISVLLVSILGIGVLPFIGGFENREKIKKLLCKYESRGDLFAVLEIVRDYFKIKDSSIKRKYLRDNLLSYNKINEIKSSTAQYYSILKDVGFLPMDYKVGSISDLNRNERNFDILRAILTGAFYPHIARVQLPDVKYLSTSSGAVEKDPEAKMIKYWIRSEEYQDKLEEYKTKISQETQKVDLEDLPLPATRAFIHPSSVLFSTNSVNLEDAKLLSEVDGPISRQSKIPTVVKYPFVLFTTSQVTNKLYLRDLTPTTTLSLLLFGGAISYDIGGTIHSPGIVVDNWLPIRTWCKNGVLIKELRTQLDEAIRKKLESPDYAKKSQIDNSGADKTLKIVEKIIASEQ
The following text describes a protein:
Function:
Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Activates the JNK signaling pathway. Inhibits T-cell receptor signaling and T-cell mediated immune responses, acting, at least in part, by inducing degradation of E3 ubiquitin ligase UBR2. Dephosphorylates and thereby induces 'Lys-48'-linked ubiquitination of UBR2, leading to proteasomal degradation of UBR2. Dephosphorylates and thereby inactivates tyrosine kinase LCK. Inhibits UBR2-mediated 'Lys-63'-linked ubiquitination of LCK. May play a role in B-cell receptor (BCR) signaling and B-cell function.
Subcellular Localization:
Cytoplasm.
Sequence:
MGNGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGEGCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNLGFQRQLQDFEKHEVHQYRQWLKEEYGESPLRDAEEARNILVHQRAAVSRPIPEPPRPRGRTEGHLRHRGEACPRAPVNCCCSPTRAHPPFLASCIFSWLGFFNYYLFLTMSLTLFLSPFTQIHALSDNLVLLPGFLHSLPFSQFMLISQKTLMLIICCETSSEQSSRYCCNGCLKPLFF
The following text describes a protein:
Function:
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
Subcellular Localization:
Secreted.
Sequence:
MARSVTLVFLVLVSLTGLYAIQKTPQIQVYSRHPPENGKPNILNCYVTQFHPPHIEIQMLKNGKKIPKVEMSDMSFSKDWSFYILAHTEFTPTETDTYACRVKHASMAEPKTVYWDRDM
The following text describes a protein:
Function:
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Sequence:
MQASSPLPNSCIDSGSSMQLYETIARRLEPQRARSLAILALQLASVFKKNATTSSRSTEVLGLRFPGPVGLAAGFDKNGELYRYLPSAGFGFAEIGTVTLLPEPGRSLGIHAVANSLARHARGHHIPLGLSISMNRATRPQAMAQDYLACLRAAWQHADYVVLNLGVRAGPDLHQPEHRNVLADVLEAVRTEKEVLFRQFGYRLPTMIKLDQARGGTQQLMDMALKAGIEGVVLCGAGSRPTTLLEQMVKTLAGRIPIVAVGGIRTPQDAADRLAAGASLVQVHTGLMQSGPKLISQMNAFLAANAPRS
The following text describes a protein:
Function:
Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to centrioles.
Domain:
The coiled coil domain is necessary and sufficient for interaction with sas-5; The 35 nM long coiled-coil domain mediates homodimerization while the globular N-terminus links the dimers at an angle of 40 degrees to form the inner ring.
Sequence:
MTSRLALFDQTLSASLLQRVNSDPHDYKAYKTRVKLKILEQRGEHGEKELKFEISRADDFEFLFAAILNNEKYQELAKAHELTVDFDTFPKVIIQHLLCKNIVKTADEDGIEVDARAKPGYHSIIENRGVPPTEINIKLEKDKNSCEFEIFSKTPISKGKIFAMSLQAVRGDLLIAHLLKICSSQSTKIATLHRSTDELAALKTKVAEMEKRNQSIEDLEKKIEEQEERIREMEDELELVKEERENIRVIAEEKEDLVAELQNDLESVNRELEENQEELEIVGKMLGEEQGKVDQLQKRNVAHQKELATLQRNFQKVESQLKRSSVEQSQQSLDIRKLRELEADLKEKDSMVENLTQTVGILKKELEDERVKMQETMTSFESLKVENESVKERLAMYRNQRFSPAPVGLQTTTIPSAGVGFKTVLGQNSPYANNPNMRTPFRDTSSALNTGLTYQNSITPLPNTTRFLMADDTTGSSVTNTPPVLRNPL
The following text describes a protein:
Function:
Probable E3 ubiquitin-protein ligase that may regulate the response to iron deficiency and thus contributes to iron homeostasis.
Subcellular Localization:
Membrane; Single-pass membrane protein. Nucleus.
Sequence:
MGSGGDLRSLLDRWIFISDIYRHYCNAEDEIIFSALDARVKNVACTYSLEHKGERSLHLSCIRVIQTSLTQHMLKEEEQVFPLLVEKFSFKEQATLVWQFVCSVPVYVIADFLPWLSSSITTDERRDMYKCLCKVIPEKKLLRQVILTWMDGKNKEAGSNHGINSESLLSIDSGSSQFLKETNRRFSTFQSSKIGKRKLSDSEIDDCDSLKHPINEILHWHNAIKRELQDIAKEARKIQHSGDFSNLAIFNTRLQFIADVCIFHSIAEDQIIFPAVGEVSFVEEHAAEESQFNTFRILIENMQKAGVNSTSVEFYSKLCSHADQIMDTIEKHFNDEEAMVLPSARLHFSHKKQRELLYRSICVIPLKLLERILPWLVASLNLDDARSFLRNMKLAAASSDSALVTLLCGWACKGRSNDFCKSSRLICLPSEEADCSLSMANMNDVNEVCSRDYMPCPCQSSSCFFPLASLNELSLLQEDHYNRPVKCTHHSLPENKIVCKSSVSMNAKSCNKNSCCIPDLGVSTGELVVNPRPSAKSLYNFSAPSFNSSLFLWETKIMSSISETTSRPIDSIFKFHLAIRKDLEYLDVESGKLVDCDESFLRNFSGRFRLLWGLYRAHSNAEDDIVFPALESKESLHNVSQSYTIDHKQEEKLFEEISKVLSDLSHLHESLIMHKYNADSVDKPIFPSCDVELMKNHNELARKLQDMCKSIRVSLDHHVIREELELWPLFDKHFSVEEQDKILGRIIGTTGAEVLQSMLPWVTSALTQEEQNKMMDTWRKATKNTMFDEWLNGWWKGGTLPPSQASSDKNLDSQENVQESEMFKAGWKDIFRMNQNELESEIHKVSRDSTLDPRRKAYLIQNLMTSRWIASQQNIPQESDGEKANASVEYSPSYRDSEKHIYGCEHYKRNCKLVASCCNKLYTCRFCHDEVSDHSMDRKLTIEMMCMQCLVIQPIGPTCTTPSCHQFTMAKYYCSICKFFDDERMVYHCPSCNLCRVGKGLGIDFFHCMTCNCCLGMDLLEHKCREKGLETNCPICCDFLFTSSTIVRSLPCGHFMHSSCFQVLFY
The following text describes a protein:
Function:
Probably forms a large homooligomer on which other magnetosome subunits assemble. Required for formation of functional magnetosomes from pre-existing vesicles.
Miscellaneous:
MISCELLANEOUS: This bacteria makes magnetosomes of about 43 nm diameter containing magnetite (Fe(3)O(4)).
Subcellular Localization:
Magnetosome membrane; Peripheral membrane protein. Note=Reversibly binds to magnetosomes. Forms oligomers that cover the surface of the magnetosome (By similarity).
Sequence:
MSSKPSDILDEVTLYAHYGLSVAKKLGMNMVDAFRAAFSVNDDIRQVYYRDKGISHAKAGRYSQAVMLLEQVYDADAFDVDVALHLGIAYVKTGAVDRGTELLERSLADAPDNVKVATVLGLTYVQVQKYDLAVPLLIKVAEANPINFNVRFRLGVALDNLGRFDEAIDSFKIALGLRPNEGKVHRAIAFSYEQMGRHEEALPHFKKANELDEGASV
The following text describes a protein:
Function:
Plays a role in the transcription of the viral late genes by acting as a late promoter recognition subunit. Associates with host RNA polymerase (RNAP) core and thus replaces the host sigma-70/rpoD subunit in the complex. May also play a role in DNA packaging by interacting with the terminase subunit gp17.
Sequence:
MSETKPKYNYVNNKELLQAIIDWKTELANNKDPNKVVRQNDTIGLAIMLIAEGLSKRFNFSGYTQSWKQEMIADGIEASIKGLHNFDETKYKNPHAYITQACFNAFVQRIKKERKEVAKKYSYFVHNVYDSRDDDMVALVDETFIQDIYDKMTHYEESTYRTPGAEKKSVVDDSPSLDFLYEAND
The following text describes a protein:
Function:
Plays a direct or indirect role in pre-rRNA processing.
Miscellaneous:
MISCELLANEOUS: Present with 2100 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRYNNYDNSGSSFLTRVVKKSDMEKTLLLNREIDDWKSNDKKKAYKERGRVYASCSFIEVSFSQIRAVDVEKKIENAEQLRDLTRNIVKNKTSSLNEITPSKNRVTSACNSERRTTSQEANNLEGYHSCAQGTSRSASITKKYSKKTTSRPKREKRQTILPNGEIKECSKCKDTWTIQWRSGPDQNRELCSPCGLAYGKRLKKENEKKRQAADKRIDRNNP
The following text describes a protein:
Function:
Cell wall formation.
Subcellular Localization:
Cytoplasm.
Sequence:
MLETTIDFSRYSSVKIGTPLKVSVLENDDEISQEHQIIGLANNLLIAPSAKNLALLGKNYDYICDKGECVEIGGAANASKIFNYFRANDLEGLEFLGQLPGTLGALVKMNAGMKEFEIKNVLESACINNQWLEKEALGLGYRSSGFSGVVLRARFKKTHGFREGVLKACQSMRKSHPKLPNFGSCFKNPPNDHAGRLLEGVGLRGYCLKRVGFAKEHANFLVNLGGAEFEEALDLIELAKARVLQEYGIHLEEEVKILR
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MAPRASSPALSENEFDIFDALAGGDEAAQPMRVTADLGIDLEFGSDDGSDDEAFIAAKQAAANRKNANAPGKSGKKGGGFQAMGLNVALLKAIAQKGFKIPTPIQRKAVPLILQGDDVVGMARTGSGKTAAFVIPMIERLKTHSAKVGARGVIMSPSRELALQTLKVVKEFGRGTDLRTILLVGGDSLEEQFNSMTTNPDIIIATPGRFLHLKVEMGLDLSSVQYIVFDEADRLFEMGFAAQLAEILYALPTSRQTLLFSATLPKSLVEFARAGLQEPKLIRLDAESKISPDLKSAYFTIKSGDRDGALIHLLENVIKMPVGQTEVWKQAKEEADNLSKGKKRKRGSGNPKDAPVEESTIIFAATKHRVEYLSTLLKAAGYPVSYVYGNLDQTARQEQVKDFRAGLTRILVVTDVAARGYRHATHKPRHQLRLPFSTKNLCSSSGEDGPRWAEGLGIQPVQTCRSAISHRLTNVPWQTPSGCLAPYQLEPSVELVNKQLTDDEDLVNLLNVAEKGERQYQRTRNQASNQSVHRAKDLASDSKFAETHMLFNDEMHDALRAKEDMLERIQGFRPAETVFEIGKRGTNSEAAEIMRKRRVAVERQKTKQAFNKANDESSGLTRPTADALPDDELDSEDDQQAAVGDYESESDELEVTVSQPESKKSGKDVWRSDEFFMSYLPKENFAEEKAYGVQGGDAGNSNFVSAARSAEMSLVNDEIQGFADASKPRMRWDKKSKKYVSRANDEDGSKGAKMIRGESGQKIAASFRSGRFDDWRKANKVKMQRVGEMEAPNRSTQFNSGGPRYKHKAEKAPKQADRYRDDYHVQKQRVQEAKEKRIGHFKDGGAKNELKDVDTVRKERRVQEKRKEKNARPSKKRKF
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity).
Subcellular Localization:
Early endosome. Note=The endosomal localization is dependent on the interaction with TSG101; [Isoform 1]: Cytoplasm, cytosol. Nucleus. Note=Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli; [Isoform 2]: Cytoplasm, cytosol. Nucleus. Note=Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli; [Isoform 3]: Cytoplasm, cytosol. Cell membrane; [Isoform 4]: Cytoplasm, cytosol. Cell membrane.
Domain:
The RING finger is required for ubiquitin ligase activity.
Sequence:
MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSLEFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKKSKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPLGGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPALGPDSCSVGIDE
The following text describes a protein:
Function:
A probable glucose kinase (Probable). Required for glucose repression of many different genes, restores glucose kinase activity in E.coli glk mutants.
Subcellular Localization:
Cytoplasm.
Sequence:
MGLTIGVDIGGTKIAAGVVDEEGNILSTHKVPTPTTPEAIVDAIASAVEGARVGHEIVAVGIGAAGYVNRQRSTVYFAPNIDWRQEPLKEKVEARVGLPVVVENDANAAAWGEYKFGGGKGHRNVICITLGTGLGGGIIIGNKLRRGHFGVAAEFGHIRMVPDGLLCGCGSQGCWEQYASGRALVRYAKQRANATPERAEVLLALGDGTPDGIEGKHISVAARQGCPVAVDSYRELARWAGAGLADLASLFDPSAFIVGGGLSDEGDLVLDPIRKSYKRWLVGGNWRPVADVIAAQLGNKAGLVGAADLAREPDPIM
The following text describes a protein:
Function:
Soluble form that is released in blood plasma and other body fluids following proteolytic cleavage in the juxtamembrane stalk region.
Sequence:
MKRYRHVSSPSSHLLSSRQSSGAAPCPPTPDPHCRSSAGSPGHAVGRPPGRPGGPWSARGARPGGPGWRSPCALSLPREPTGRALVLASPSPVPRGSTGTRRSPTPPPFISAASHHPTGRPAASRRIPQHPAASPGRAGPGRAGPGTMGSVPGRPAWALWGALWWALWWAQLWRAGGLEEHLRPGNFSADEAGAAEFAARYNESAEQVLYRETAASWDYSTNLTQHNAQLQEKAALVSQEFTEAWGKKAKELYESIWSNFSDPELRRVIGSVRTLGPANLPLEKRLQYNSLLSVMGNIYSTAKVCPNITAECWSLEPELTDIMASSRSYKKLLFAWEGWHDAVGIPLRPKYQEYVKLSNEAVQPDGFPDTGAFWRSWYASSHFTEDLERLFQELQPLYLNLHAYVRRQLNRRYGDKFVNLRGPIPAHLLGNMWAQTWTNVYDLVVPYPDKPNLDVTSTMLKQGWNATHMFRVAEEFFTSLGLLLMPQEFWDKSMLEKPTDGREVVCHASAWDFYNRKDFRIKQCTVVTMDQLAVVHHEMGHVQYYLQYKELPVSLRRGANPGFHEAIGDVLSLSVLTPGHLKTLGLLDNVTEDSESDINFLLKMALDKIAFLPFGYLIDQWRWDVFSGRTPSSRYNYDWWYLRTKYQGICSPVARNETHFDPGAKYHVPGTTPYIRYFVSFILQFQIHQALCSAADFKGPLHRCDIYRSVEAGKKLKAVLQAGASKPWQDVLLNLTGTNQLDAGPLLLYFSNLTDWLKKQNGANQEVLGWPDFDWRPPLPDGYPGDIDKVSDEVEAQKFLEEFDRTAQLAWYENTEASWAYNTNITEHNRQIMLDKSLQVSQHTLDFGKKARQFDDTDFKNSSVKRTLKKLQDLGRAALPQNELKEYNELLSDMETVYSVAKVCRKENGPCVPLEPDLTELMATSQNYEELLWAWQGWREAAGKPVRQKFERYVELSNKAARLNGHADNGVSWRAMYETPTFEQDLERLYQELQPLYLNLHAYVRRQLHRRYGDKFVNLRGPIPAHLLGNMWAQTWSNIYNLVVPFPSASQVDATPAMKNKNWNPKKMFEESDSFFKSLGLLPMPEEFWEKSMLEKPSDGREVVCHASAWDFYNGKDFRIKQCTTVNMEDLITVHHEMGHVQYYLQYKEQPVVFREGANPGFHEAIGDVLALSVSTPRHLHSIGLLDNEGEGYESEINYLMSMALDKIAFLPFGYLMDQWRWKVFDGRITKENYNQEWWNLRLKYQGLCPPVIRSQTDFDPGAKFHIPANVPYIRYFVSFVIQFQFHEALCRAASHTGPLHKCDIYKSQKAGKLLSDAMKLGSSKPWPEAMQILTGQPNMSAAALMSYFKPLLDWLVTENNRQNEVLGWPQFTWKPDNPSDAPTSSKVNFLGMSLEPGQASAGQWILLVIGLLSLVGVVGLSVHLFFRKRAETPQFGSEVELRHS
The following text describes a protein:
Function:
Catalyzes the oxidative deamination of D-amino acids with broad substrate specificity (By similarity). Could be responsible for the degradation of diet-derived D-alanine in the intestine (By similarity). Maintains the asexual state of worms and represses early ovarian development. Following sexual induction, the enzyme is required for differentiation of oogonia into oocytes in the developing ovaries.
Subcellular Localization:
Peroxisome matrix.
Sequence:
MHIAVIGAGINGISVAVNLLETLPGVKVTIFTHNVTPNTTGDVAAGLFRPYLVAEGDHRIKKWCRSTYNFLENFIATNPKHHKYGCCYLEVFELDTEPLEKTLFNEIVGNSRFLNEFELKRYPTAKYGLASTSIISEGKKILPYFYEKFKMLGGKIKVMQVKNFDEVQMIHNFPIVINCSGLGSRSLCNDMDIYPVRGQIIRIHAPWIKYSFNKAEHYIIPQSDGVVVLGGTTQENNWNTLPDENDTKNILNGCKTILNGLEECNILSVNVGLRPGRKSVRLEKENRTNFTTGNKYTIIHNYGHGGSGFTLFWGCAKDVGQLVSDILLKAKL
The following text describes a protein:
Function:
Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.
Subcellular Localization:
Cytoplasm.
Sequence:
MGHQNAAVSENQNHDDGAASSPGFKLVGFSKFVRKNPKSDKFKVKRFHHIEFWCGDATNVARRFSWGLGMRFSAKSDLSTGNMVHASYLLTSGDLRFLFTAPYSPSLSAGEIKPTTTASIPSFDHGSCRSFFSSHGLGVRAVAIEVEDAESAFSISVANGAIPSSPPIVLNEAVTIAEVKLYGDVVLRYVSYKAEDTEKSEFLPGFERVEDASSFPLDYGIRRLDHAVGNVPELGPALTYVAGFTGFHQFAEFTADDVGTAESGLNSAVLASNDEMVLLPINEPVHGTKRKSQIQTYLEHNEGAGLQHLALMSEDIFRTLREMRKRSSIGGFDFMPSPPPTYYQNLKKRVGDVLSDDQIKECEELGILVDRDDQGTLLQIFTKPLGDRPTIFIEIIQRVGCMMKDEEGKAYQSGGCGGFGKGNFSELFKSIEEYEKTLEAKQLVG
The following text describes a protein:
Function:
Gustatory receptor required for response to the bitter in taste neurons. Gr93a cells respond to bitter compounds such as caffeine. Flies avoid bitter substances, suggesting that Gr93a neuron activity is sufficient to mediate avoidance behavior.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFSSSSAMTGKRAESWSRLLLLWLYRCARGLLVLSSSLDRDKLQLKATKQGSRNRFLHILWRCIVVMIYAGLWPMLTSAVIGKRLESYADVLALAQSMSVSILAVISFVIQARGENQFREVLNRYLALYQRICLTTRLRHLFPTKFVVFFLLKLFFTLCGCFHEIIPLFENSHFDDISQMVGTGFGIYMWLGTLCVLDACFLGFLVSGILYEHMANNIIAMLKRMEPIESQDERYRMTKYRRMQLLCDFADELDECAAIYSELYHVTNSFRRILQWQILFYIYLNFINICLMLYQYILHFLNDDEVVFVSIVMAFVKLANLVLLMMCADYTVRQSEVPKKLPLDIVCSDMDERWDKSVETFLGQLQTQRLEIKVLGFFHLNNEFILLILSAIISYLFILIQFGITGGFEASEDIKNRFD
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MKVKCCDGIVLELEDALVYASLTVKQLIDEKIPSRRCFGVWIFDGKDENYEISFEKEISSKTLLKINEYVKKHADAASTSSNRISRSLRSWDLEFIKVDRHTLFALVLAAKYLQITDLINLSSETVRAKTRGKTPEKIHRYYNLKNDMTPQEEEEY
The following text describes a protein:
Function:
Free serine kinase that uses ATP to phosphorylate L-serine to yield O-phospho-L-serine and ADP. O-phospho-L-serine serves as a substrate for SbnA and is a precursor for staphyloferrin B biosynthesis. Is also a DNA-binding regulatory protein that senses heme to control gene expression for siderophore biosynthesis. Binds to DNA within the sbnC coding region and is required for expression of genes in the sbn operon from sbnD onward.
Sequence:
MNHIHEHLKLVPVDKIDLHETFEPLRLEKTKSSIEADDFIRHPILVTAMQHGRYMVIDGVHRYTSLKALGCKKVPVQEIHETQYSISTWQHKVPFGVWWETLQQEHRLPWTTETRQEAPFITMCHGDTEQYLYTKDLGEAHFQVWEKVVASYSGCCSVERIAQGTYPCLSQQDVLMKYQPLSYKEIEAVVHKGETVPAGVTRFNISGRCLNLQVPLALLKQDDDVEQLRNWKQFLADKFANMRCYTEKVYLVEQ
The following text describes a protein:
Function:
Involved in protein precursor import into chloroplasts. Part of the motor complex consisting of a co-chaperone (TIC40) and a chaperone (HSP93) associated with the import channel (TIC110). Causes the release of bound transit peptides from TIC110 and stimulates ATP hydrolysis by HSP93. Involved in reinsertion of proteins from the chloroplast stroma into the inner membrane.
Subcellular Localization:
Plastid, chloroplast inner membrane; Single-pass membrane protein.
Sequence:
MESLVLASSCSASPRLPLISSAARFRRLPGSVPPPTVAAASTGGAARKGPRRPRLFVVAAAAPRGSGNVFEGLRAKGFASVSSSTGNENMSTGTGTLPPVPPPSSYFGSPVFWIGVGVALSVAFTTVSSMVKRYAMEQAFKSMMTQAPPNSFGSNSPFPFGMPPQASPTAPSSFPYLEPKKDTSPQVSTVDVSATEVEAAGTSKEVDVTETPEPSKKFAFVDVSPEELQQKNLQSSLETVDVKHDSTDSESKEDIEEKVLPTNGATFKPNEDAARGPTEPSNSGPMLSVETIEKMMEDPTVQKMVYPYLPEEMRNPDSFKWMLQNPMYRQQLQDMLNNMGASPDQWDNRMVDHLKNFDLSSPEVRQQFAQVGMTPEEVVSKIMANPDVAVAFQNPKIQTAIMDCSQNPLNIVKYQNDKEVMDVFMKISQIFPQING
The following text describes a protein:
Function:
Eukaryotic-type DNA polymerase involved in viral genomic replication. DNA synthesis is protein primed, and acts in a strand displacement replication. Assembles in complex with viral pTP, DBP, host NFIA and host POU2F1/OCT1 on viral origin of replication. The polymerase covalently transfers dCMP onto pTP, thereby initiating complementary strand synthesis.
Miscellaneous:
MISCELLANEOUS: This DNA polymerase requires a protein as a primer.
Subcellular Localization:
Host nucleus.
Sequence:
MALVQAHRARRLHAEAPDSGDQPPRRRVRQQPPRAAPAPARARRRRAPAPSPGGSRAPPTSGGPPASPLLDASSKDTPAAHRPPRGTVVAPRGCGLLQVIDAATNQPLEIRYHLDLARALTRLCEVNLQELPPDLSPRELQTMDSSHLRDVVIKLRPPRADIWTLGSRGVVVRSTITPLEQPDGQGQAAEVEDHQPNPPGEGLKFPLCFLVRGRQVNLVQDVQPVHRCQYCARFYKSQHECSARRRDFYFHHINSHSSNWWREIQFFPIGSHPRTERLFVTYDVETYTWMGAFGKQLVPFMLVMKFGGDEPLVTAARDLAVDLGWDRWEQDPLTFYCITPEKMAIGRQFRTFRDHLQMLMARDLWSSFVASNPHLADWALSEHGLSSPEELTYEELKKLPSIKGTPRFLELYIVGHNINGFDEIVLAAQVINNRSEVPGPFRITRNFMPRAGKILFNDVTFALPNPRSKKRTDFLLWEQGGCDDTDFKYQYLKVMVRDTFALTHTSLRKAAQAYALPVEKGCCAYQAVNQFYMLGSYRSEADGFPIQEYWKDREEFVLNRELWKKKGQDKYDIIKETLDYCALDVQVTAELVNKLRDSYASFVRDAVGLTDASFNVFQRPTISSNSHAIFRQIVFRAEQPARSNLGPDLLAPSHELYDYVRASIRGGRCYPTYLGILREPLYVYDICGMYASALTHPMPWGPPLNPYERALAARAWQQALDLQGCKIDYFDARLLPGVFTVDADPPDETQLDPLPPFCSRKGGRLCWTNERLRGEVATSVDLVTLHNRGWRVHLVPDERTTVFPEWRCVAREYVQLNIAAKERADRDKNQTLRSIAKLLSNALYGSFATKLDNKKIVFSDQMDAATLKGITAGQVNIKSSSFLETDNLSAEVMPAFEREYSPQQLALADSDAEESEDERAPTPFYSPPSGTPGHVAYTYKPITFLDAEEGDMCLHTLERVDPLVDNDRYPSHLASFVLAWTRAFVSEWSEFLYEEDRGTPLEDRPLKSVYGDTDSLFVTERGHRLMETRGKKRIKKHGGNLVFDPERPELTWLVECETVCGACGADAYSPESVFLAPKLYALKSLHCPSCGASSKGKLRAKGHAAEGLDYDTMVKCYLADAQGEDRQRFSTSRTSLKRTLASAQPGAHPFTVTQTTLTRTLRPWKDMTLARLDEHRLLPYSESRPNPRNEEICWIEMP
The following text describes a protein:
Function:
Activator of KIF1B plus-end-directed microtubule motor activity. Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTMITIDYIKDIIKRSDKLSEEIDPDQTPYKSKYEAIELLVKELKKEINENEKELNQQQQQDILDYLVVIDSKLGELFIATEEITLGLNICRDCLKSLESIKNKFPLETISTFQSIAIIDINKNHFENGKQLLIKSENLINQTIEKQQEQEQEQEQQFKDKLESLQLQNYFYFAQLYGLLKDSELSSKYCELTLRKQLKRNNFDRLEWCKNSLMLAEYYLSELNFDYAKQCFLVSNYICKGIENEDDREETQANIYLVMAKFYLEFLHFFRDIENLNHCHRVNNNNKNNNNENDIDFVQGGLSSISLSDKQKEKEKEDKLFNENQIKKEKMLDLISFNKRSLNIDKPLFTELGSELLDKIYNHSTFTSPIDLIVVKDQPSARDIFLKSQHFFNKSKKYYKLDGFVSQHIKILFDQINLFEYLNMFESNAGRKIGIHKKKIELIQPLLKELNPTYFLSSIRSIYFKIAEIYSEISKIYQCVCTNLREIQTYNECLFKSMEYYNLFLNSYNDGEVPNSPKITEEEKMKSIIEDFEVYINAKLELAVCHKNVKGVNKLVLEHLEKSLNLFRSIITLLDSVPKDISSRHTQEYHLCSQMSSLLPQKIQFLSSNKTPNPGQWYGK