lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MLSNGEILTLAASIAEMCMCFCYLFLIMMIATTRVSALKTPFYFIFVVTAFAAVLNLVVIIILRLFNQVFFFGPEFGTICNCLSYVSHMLVFTQTTLKAMQVTNRFTALFFPLKHDDIWAYRIIWVIVIASYCVPAGVFSFMIINQPSLYQDAGGRLKYAGIERSAQELAKLISAADQVVFVIVTLPMNVMLLVKMRRLRKENLTQFQKERMYLYYVLVITVAHMIKGAHQVFWLIATTTQNTSWNFIATYTAARKSAPSSGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAVGALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
The following text describes a protein:
Function:
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
Sequence:
MSSILSSVKQMQEADRRAIHELGIPGCVLMYNAAKCVTEHIKNKYPETNNFGILCGKGNNGGDGFAIAHILSIAGKSVRVVALAKENEYVNDALLYLKLALKEGIDVRFPNSIESCIEETKKLSNCDLIVDALLGTGTRGEIREPFKSVINNIAKEPKIVAVDLPSGMNGDTGEICGACVKAHSTVTFAAAKKGIVGHPEYTGELIVGDIGMPPICLNDDEWSKFVAKQTQ
The following text describes a protein:
Function:
Potential calcium sensor that binds calcium in vitro.
Sequence:
MIKAKHDASSSPPPLTDGNHNNVTSPKSALGKLCRKLSSRKSTEKQRSLLGSDSETTNKLICSELQTVFDYLDVNGDGKISPAELQGCVTTVGGTLSVDEAEETVKSSDLNGDGLLDFEEFQKLMETSGEDEKNDTLKEAFAMYEMEGSGCITPTSLKRMLSRLGDSKSVEDCKAMIRKFDLNGDGVLSFEEFRVMMH
The following text describes a protein:
Function:
Transcription factor which regulates the expression of various genes, including those involved in cuticle synthesis and maintenance, such as collagens, and in lipid metabolism. Binds to promoter regions of genes, at 5'-[(T/G)TTTTTT(A/T/C/G)]-3' consensus sequences. Heterochronic protein which controls the choice of stage specific cell fates, including at the juvenile to adult transition. Promotes differentiation, together with transcriptional cofactor mab-10, perhaps as part of a transcriptional complex. Required for vulval morphogenesis and egg laying; perhaps by acting in a subset of the lateral seam cells. Involved in the exit of seam cells from the cell cycle. Required for specification of uterine pi-cell fate, acting upstream of lin-12 Notch signaling, perhaps via maintenance of lag-2 expression in the anchor cell (AC). Involved in morphogenesis of the specialized male tail used in mating. Acts cell non-autonomously from the hypodermis to regulate expression of genes in the intestine, including genes involved in lipid metabolism. May regulate vitellogenesis via the mTORC2 signaling mediated pathway, independently of daf-16. May promote nuclear accumulation of mab-10 in seam cells post-transcriptionally. Dispensable for seam cell fusion; [Isoform c]: Required for seam cell fusion.
Subcellular Localization:
Nucleus. Note=Accumulates in nuclei of hypodermal cells in a temporally restricted fashion, beginning during the larval L4 stage.
Sequence:
MDQTVLDSAFNSPVDSGIAGTTTGSGSTTHFGVGTNFKVSVRSSSRSTDGTDSTDGANSDNVTGSTGSTPAHHSITNLNMALSQHSIDSATAASSTNPFPHFNQADLLNFHQNSLLPHHMFSQFGRYPQFEQKPDVGVLQQQMQMREAKPYKCTQCVKAFANSSYLSQHMRIHLGIKPFGPCNYCGKKFTQLSHLQQHIRTHTGEKPYKCKFTGCDKAFSQLSNLQSHSRCHQTDKPFKCNSCYKCFTDEQSLLDHIPKHKESKHLKIHICPFCGKSYTQQTYLQKHMTKHADRSKASNFGNDVVPADPFDPSLLSWNPMQGMGDNAHDSSSFNISSLTDQFAANTMIGSQSTNYNPAFQNSAFSQLFNIRNNRYLSEYPTSTKNGERAPGFNMITPLENIQRYNGSSSSATAVVTATGSAVVSSTPSSTSSSSAGSSSSQGGVFNPQSLINNMKNHSY
The following text describes a protein:
Function:
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
SYLMNHFDLPTCDSCRDADDKHKLITKTEAKQEYLLKDCDLEKREPALRFIVKKNPRHSQWGDMKLYLKLQVVKRALEVWGSQDALEDAKEVRQENR
The following text describes a protein:
Function:
May promote appropriate targeting of ribosome-nascent polypeptide complexes.
Sequence:
MQTTVPCNGDEPIVEDDDDDDEDDDEDEDEKDDDGVAGVDASGRSRQSRSEKKSRKAMEKLGMKAITGVSRVTIKKNKSVLFVLSKPDVFKSSNSDTYVMFGEAKIEDLSTQLHSQAAEQFKAPSPSSVISKGEPSMAAAHDDEEVDETGVDKKDVELVMTQASVPRSRTVKALKAAGGDIVSAIMELTN
The following text describes a protein:
Function:
Fatty acid desaturase that catalyzes the introduction of the third double bond at the Delta(10) position in d18:3Delta4,8,10 triunsaturated sphingolipid long fatty acid chains. The cytochrome b5 domain probably acts as the direct electron donor to the active site of the desaturase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The histidine box domains may contain the active site and/or be involved in metal ion binding.
Sequence:
MRAVWALLWALQLGTLVGCALVLGVHHFSGDNLTKQSAIPTKSSKAKPISDQKAAVTSGSTCAVREKARKDGLVLLDGNWYNVEKFVHHHPGGVEVLEQYLGADISFVFRVMHRNPTQIMKYRKPVRAATPEELEALTSRRQEVCLDMMDDFVTNSIDIASPEMLPKPTQFDLKSFEKDFIDLYEEFVAQGYFKPSTTWLLWNTAVLISIIALSVISMKVLPPTSFVLPGALLGLFWHQSGFLMHDAEHHNLAGNERLNDILGWIYGTVFLGVNGAWWREEHREHHAFLNTYDDESGFKDPQMREDVWIQNKKLIPFFGDEIIHFLTNFQHILFLPIIFIVGRVGIVVDSTLTERKFRPWTILGNVCHILLHYAILSQTSRPIPVYIIGSLWQAILSLQLLGNHYVKPWNRLNDATEGNFCVWQILSTQDFACPRWSRWLYGGLNFHYSHHLFPTLSREYFHITSPRIRTLCEKHGLPFIEIAFIDCVVGMVNNFNEVRKDFATKGHGSVAFMYT
The following text describes a protein:
Function:
Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MSNSAKSPSGIVGDEGRRNYPMSAHTLVTQEQVWAATAKCAKKIAEDYRSFKLTTGNPLYLLCVLKGSFIFTADLARFLADEGVPVKVEFICASSYGTGVETSGQVRMLLDVRDSVENRHILIVEDIVDSAITLQYLMRFMLAKKPASLKTVVLLDKPSGRKVEVLVDYPVITIPHAFVIGYGMDYAESYRELRDICVLKKEYYEKPESKV
The following text describes a protein:
Function:
Catalytic component of the DSC E3 ubiquitin ligase complex which is required for the srbA transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. Required for growth during hypoxia and triazole drug susceptibility, as well as for virulence in a murine model of invasive pulmonary aspergillosis (IPA).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDHRGSLFFFIVILYFLLSSQSHPPLISQDREHQRELERERQALRLLNESRYGDFDPRADKWLPFIGARKNDSYDWGLLADAQDRARYQLQSAFSNAGLVPPSGLEDGNSSRSLNLSQLALPVYRNSTGTLRGDWVRRKLDTNRPSLNTTAIVLEHEYFTHEFGQNITGNSGEFYLNVHEGGGEELKLPQGHVREIRATLSVETDDYWGHTWYISLYGVHFPETGGTVLTTTSEKFRGVFSLPHLTMTVDSYNISHQLLLKSLSDTIAEKQNRPPTLFPWSSLVGTDQVEFPSPKCEHIVYLQQHPVAIEGYLADQVVIDQIEQELRFPMGAPIPSPPSMVMSGVVYSPDCGYILETKGAPDFPPTDGLYLQGPKVEEYAKYAARLVFLISAVFIGQIMLLMRQIKDASTPSTRSRISFYTIALMAYGDAFVLVFILLELYPAVSFLVMTTLAFFAFLSVSYIGMKFMIEIWAIQAPERREQERRSSPPASSTRSSGLPLPATATGVRDSGATPIIILTPDQDPPAEEEEGTPTPNRSTVPTAQETRSDIGAMYARFYFVLFVMLVVSIWSFLWPNRLGAWYARALAFTYLSFWVPQIYRNVMRNCRKALRWDFVIGQSCLRLVPFVYFLTVRENVLWVRPDTKTALCLAGWVWIQVWLLASQDILGPRFFVPRGWAPPAYDYHPLLRDDPESGPDVQSDGGVLPITALRADGRDSSDSKDDDRPRNKDRKKAIFDCAICMQDIEVPVLAAPGAAGGSSVANGATSLLTRRNYMVTPCHHIFHSACLESWMKLRLQCPICRESIPPV
The following text describes a protein:
Function:
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation.
Subcellular Localization:
Nucleus.
Sequence:
MSGRGAGGFPLPPLSPGGGAVAAALGAPPPPAGPGMLPSPALRGPGPSGGMGVPGAAAFRPMGPAGPAAQYQRPGMSPGSRMPMAGLQVGPPAGSPFGTAAPLRPGMPPTMMDPFRKRLLVPQAQPPMPAQRRGLKRRKMADKVLPQRIRELVPESQAYMDLLAFERKLDQTIARKRMEIQEAIKKPLTQKRKLRIYISNTFSPSKADGDNAGTAGTPGGTPAADKVASWELRVEGKLLDDPSKQKRKFSSFFKSLVIELDKELYGPDNHLVEWHRMPTTQETDGFQVKRPGDLNVKCTLLLMLDHQPPQYKLDPRLARLLGVHTQTRAAIMQALWLYIKHNQLQDGHEREYINCNRYFRQIFSCGRLRFSEIPMKLAGLLQHPDPIVINHVISVDPNDQKKTACYDIDVEVDDPLKAQMSNFLASTTNQQEIASLDVKIHETIESINQLKTQRDFMLSFSTEPQDFIQEWLRSQRRDLKIITDVIGNPEEERRAAFYHQPWAQEAVGRHIFAKVQQRRQELEQVLGIRLT
The following text describes a protein:
Function:
Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSSLTEDLETPILCESCLGPNPYIRMTKDPRGKSCKVCTRPFTVFRWNPGAGSRFKKTEICATCAKVKNVCQTCILDLQYGLPVQVRDAALGIKSDAGPTSSDKAKAYFADTMEKQLEATVGSSSRAGQELVRKAARREIDYKRDRPVQSQKLCSAFARGRCERGDSCPFKHQLPTDDQLPGLQPSSNINYPYSPTSSSPSKQAVAKILTSSTSSVGLPPPSDASVRSLFISNLPPEHLEEPSIRQFFLDLAPPLQAQDIKSITLVRASNCAFVNFATRDHAELAARRCEPKMRLGDKEIRLMWGRSRPVKRNEENECKKAEVE
The following text describes a protein:
Function:
VirB proteins are suggested to act at the bacterial surface and there play an important role in directing T-DNA transfer to plant cells.
Sequence:
MKIMQLVAAAMAVSLLSVGPARAQFVVSDPATEAETLATALETAANLEQTITMVAMLTSAYGVTGLLTSLNQKNQYPSTRDLDTEMFSPRMPMSTTARAITTDTDRAVVGGDAEADLLRSQITGSANSAGIAADNLETMDKRLTANAETSTQLSRSRNIMQATVTNGLLLKQIHDAMIQNVQATSLLTMTTAQAGLHEAEEAAAQRKEHQKTAVIFGAVP
The following text describes a protein:
Function:
Toxic component of a type V toxin-antitoxin (TA) system. Causes membrane damage when induced by MqsR, slowing cell growth and increasing the formation of dormant persister cells; involved with GhoS, its antitoxin, in reducing cell growth during antibacterial stress. Overexpression causes cell lysis, forming ghost cells; both effects are neutralized by expression of GhoS. Overexpression in the presence of ampicillin increases persister cell formation (persister cells exhibit antibiotic tolerance without genetic change). Overexpression causes about 90-fold reduction in cellular ATP levels and dissipates the membrane potential.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Note=Localizes to the cell pole.
Sequence:
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF
The following text describes a protein:
Function:
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
Miscellaneous:
MISCELLANEOUS: All three cardiolipin synthases (ClsA, ClsB and ClsC) contribute to CL synthesis in stationary phase. Only ClsA contributes to synthesis during logarithmic growth phase.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTTVYTLVSWLAILGYWLLIAGVTLRILMKRRAVPSAMAWLLIIYILPLVGIIAYLAVGELHLGKRRAERARAMWPSTAKWLNDLKACKHIFAEENSSVAAPLFKLCERRQGIAGVKGNQLQLMTESDDVMQALIRDIQLARHNIEMVFYIWQPGGMADQVAESLMAAARRGIHCRLMLDSAGSVAFFRSPWPELMRNAGIEVVEALKVNLMRVFLRRMDLRQHRKMIMIDNYIAYTGSMNMVDPRYFKQDAGVGQWIDLMARMEGPIATAMGIIYSCDWEIETGKRILPPPPDVNIMPFEQASGHTIHTIASGPGFPEDLIHQALLTAAYSAREYLIMTTPYFVPSDDLLHAICTAAQRGVDVSIILPRKNDSMLVGWASRAFFTELLAAGVKIYQFEGGLLHTKSVLVDGELSLVGTVNLDMRSLWLNFEITLAIDDKGFGADLAAVQDDYISRSRLLDARLWLKRPLWQRVAERLFYFFSPLL
The following text describes a protein:
Function:
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSTPQKPKSILKQTSSYPATSNTPKPTNLSPTKTKAERDREVALYHARLIQERKEIELEILTSTEELIDFPLASAPYDASNPSPSDARAFKEMLRPFQPSDYDALILERNLDSRCGYTLCANPRPRDNKGGQWRLLGMSGKAKDFRIAKKEDAEKWCSDTCARRALYIRVQLSECPAWERSGESSATKIDLLDEPKTEEDMVMDGIGNLDLNKQEVQENQRKSGNLALERGETGQGSSRHVTTFSIVEKEVKLGNAKPPTLDSNDLSEKMGTLHLDLEGHTSTFNHKSRYGDLFGEDDDDDDTEMDTDWKI
The following text describes a protein:
Function:
Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MTRVAESKGKALKAFELTWVMYDPTDRFGLIMALFTLSPVFVTLMHVTLVASQRDLDSISMFFGQVVSEVINKVLKKTINQQRPDGARMSGSGMPSAHSQFISYFASNAVAYTCSRLNSHRYIEQWITIVGCILLAAATCYSRVRLGYHTKDQVAVGAFVGVIVGFAWHVLISTVSPWLFPLVSQTRLAQFFYLRDISHIPDLIVYQHELCYSDAAAAFKSRFL
The following text describes a protein:
Function:
Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB).
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein.
Sequence:
MSGFLRWFGGNRSKDTTKDTIVRFQEMLALYDKKEEVLERQIAEQTEIARKNATTNKRLALTALKRKKMHENELVKIEGSRNNIEQQLFSIQNANLNFETLQAMRQGAEAMKSIQRGMDADKVDQIMDKIRDQQTISEEISTMISTPVGLNAEIDEDELANELDELQQMELDSKMLGAEKPPVHTPAVPAVPSQVKDLPSISKPQELDEEEELRKLQAEFSL
The following text describes a protein:
Function:
A 5'-3' exoribonuclease, more active on 5'-monophosphorylated and 5'-hydroxylated RNA than 5'-tri-phosphorylated RNA; note there is no evidence for accumulation of 5'-monophosphorylated RNA in this organism. Translation initiation factor 2 subunit gamma but not subunit alpha protects 5'-tri-phosphorylated RNA from degradation by this enzyme.
Sequence:
MPMTFVFITVGFSITIFFSLVSIITLVAFICSVFIPILSIFFRSEGFIFAITCFIEEEVNLIVCGYDISQMNYFLKILGGGREVGRSAIEVGNSDGSIILDYGVNFDEKDNPNFPLQEMPGKVKGFVVSHAHLDHIGALPIYQIGSLNTKVYGTVATRIITETMLKDFLKLSGAKIPYEWVEVRKTMDNFMAIGYGEEVEIDSLKVSLYNAGHIPGSSIIKVSSEKGVIAFTGDINLTETKLMKPAEIENIGDANVLVMESTYGKFNHPNRKDVENDFYDKVMEVVESGGTVLVPAFSLARSQEVLSVLAERNFPYPVYYDGMSREITEIMLGFKEFLNRPDLLKKAYDNFNYVKGWEDRHRAWKEKGVIVASAGMLKGGPAVYYFKKLSENSKNAVFLVSYQAINTPGRKLLEMGKFDEYSGLLKARLEIFDFSSHAGRRQLLEIVKSVKDLEKVVLVHGSPDNESSLADLIKQEIGVEVITPENGQEISL
The following text describes a protein:
Function:
Potential calcium sensor.
Sequence:
MTWDDEQRSLCSATTLATCYSSPKTTGKKTNSTYPTILYSLILSLLCAILHFLHLPASLFRVRSPASEMDQQELKRVFQMFDRNGDGRITRKELKDSLENLGIHMTEPDMVAMIEKIDANGDGCVDIDEFGDLYQSIMDEKDEEEDIREAFNVFDQNRDGFITVEELRSVLGSLGLKQGRTIEDCKRMIKKVDADGDGMVDFKEFKAMMRNGGFAALG
The following text describes a protein:
Function:
May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.
Subcellular Localization:
Nucleus.
Sequence:
MFAKGKGSAVPSDGQAREKLALYVYEYLLHVGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRDTCEHSSEAKAFHDYSAAAAPSPVLGNIPPNDGMPGGPIPPGFFQPFMSPRYAGGPRPPIRMGNQPPGGVPGTQPLMPNSMDPTRQQGHPNMGGSMQRMNPPRGMGPMGPGPQNYGSGMRPPPNSLGPAMPGINMGPGAGRPWPNPNSANSIPYSSSSPGTYVGPPGGGGPPGTPIMPSPADSTNSSDNIYTMINPVPPGGSRSNFPMGPGSDGPMGGMGGMEPHHMNGSLGSGDINGLPKNSPNNISGISNPPGTPRDDGELGGNFLHSFQNDNYSPSMTMSV
The following text describes a protein:
Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues (By similarity).
Sequence:
MTSTSKLDANQLARQRKKLEKDRRKKVYDDQQVQGTNNSSIVSKRSVEKLYTQVLQPELGEWFQYFVPKGKRRSPAINRGYWIRMESIRQMVIRIIKANSPNVRINVVNLGCGFDPLAFQLLSLFKNQYNLNFIDIDYPDLVKNKYNMIQQSDEIKQLIGDQGSKSSDLYVMETDNYQLVGCDLKNLAYYKEILPKLVSRNVDPHPTSINIFIAEVSLAYMKPQFANPVIEISSQVNNSHFLILEQIMPDGATNAFATKMLYHFQHLRSPIQCVETYPTEKLQLQRFKRYYKHAEIKNLYGNWKFLIDYQMQKNISTIEEFDEWEEFIIFCQHYVIVHATHMDQLIYDDESSEEQKNEKAFSEMSLDSSVAISHDDRFNDEQLQLKFPAIASFKDKIYVNGGLKQTRNDENLEIDLQTGVITKLDQTENLPTARMCHTLTNLGENLVLIGGRSRPGVFFKDVYMFDTAKKWTRLADLPVGRSRHATVKISDHEVLIFGGLDASSSTTGDELFLLCNTNTNSYTPVKPIGDNDNHPIKNLQSACMIFDGKQGYIFGGMEDINVPIVNSKLYRFELVGENNISVTKVFDHSLLKRIGSKAHILENGDKLLIVGGVSPDQLFTKSTNIVTLDLNIFTFKSVEIPNVISEKVPPIFVGFELVQINNKASYIISGGAVCYSFGSCYNSVYKLEY
The following text describes a protein:
Function:
Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
Sequence:
MLKIGVLASGRGSNFQAIIDEIEAGKIPAKIEILIVDNPNAYAIERAKKHGIPYLFINPKDFQSKEAFYEKIRDELLSKDVELVILAGFMRIVKKPLLDAFPNRIMNIHPALLPSFPGLHGQKQAVDYGVRISGCTVHFVDEGVDSGPIIIQAAVPVHPDDTEDSLSERILKLEHKIFPEAIRLFAEGRLKVEGRKVKILNYKLPDKYFTNPEIGQ
The following text describes a protein:
Function:
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MVHVKSTPRQTAAMPYISSGSMCKVAHQRVSIDVDLSKHLVSGFTEIIIIPLIQQLEYVSFDCKNMRVKDVIVENRRIDHYVHDDPYKQFSDRYVSAASDPLRTHNGVRQSHFLRSKLAEFSEAPEDSAKSQLLIKIPSSVKITLQDTASLSSYTPITPSIRTPAQESIFSPITIRIDYELSHPHSGLHFDTASSEPQYWNCYTTNTEYNSSVSHWVPCVDLLDEKCTWELEISVPKTVREIGTTKIIGAQPQRKRKLRSREYIDDEDEDDEELEPEEETEDSPLDRDMVVVCSEFATAKESAHPTDMAKKVVSFQIFNPVAPHHVGWAVGSFAVWSLPSLQSFDEQDDEQEDQGNNIQVQDDDDIVPIQIYTLPMPDINEATVLNTTLVCQSMMDFYSKEFGSYPFSSYAILFLPTLPDNTMDFASLSLCSTRLLYPPELIDPMFTTTNTLAWALASQWSGVNITPLELNDMWCCIGMAGYMALQFTRKLMGINEFKYRLKMASEAIVAQDWEKPPMARTFNNASMPVSSISRDIDFIKLKAPMVLYILDRRMTKTERSFGMSRVLPKIYLQAMSGDLSNNSLSTAHFQYVCERVNRSKLEQFFAQWVFGSGVPVFRITQRFNKKRMVVEMGIRQVQLQELGQGHIIGKRGFHASAMDYLCHPDKQLTQIFTGSMTIRIHEADGTPYEHIVELKDVFTKLDIQYNTKYKRLKRRRKINKPIKPDGKEASIVEPLPKDEDMKILDEDNDDIVLVNCLGDTLLSREDCQHWNLTDPAIIGEDDESQQQNEAFEWIRVDADFEWICKVYINQPDYMFASQLQQDRDVEAQIESIRFFEDVVASSAVNSQVYSSILTRTVMDDRYFYGVRLEACNALSKFILKEVEPNQFSGGARHLIAIFRYYFCYENSNIQKNNDFTDFSRYFIQCAIPRFLANTRDTQGKCPTFVKRFLLELLRYNDNSGNPYSDVRYVVAIIDSVVACTLGDPEDKEYINDLLNELKRFENLDRWLPSYQLLVSKAILKQYLLLAVDGVYKYDDLENILEYTVVDHISPELEGVVHIREGLQDLCLTAFTVLLLAGGIKNKEILKYFFENMCFHGDPYIRTKLCDVLIDCLNFIALKGSLDDLDEDVESLVNSVNSSSINDRGEPSIFVEDYNSDLRVRREQHMRSSIRGLISLVRTKFEKYEPLQKILWDVLHSPLLSVYQRKRLFDLLRVMYRLEDSFFVTLPSPRDKVLIAKDMGKGIIILKREGILKVHLPPKPPTVHEAHSRGAAVPRADPAADSPKIKLSLSKKTRLASTAAAVQPAAAKRAKAPAVTKSPQRSRAPKSTVTKLGALPLRYVKIVPEKRKVDISAVPFNKSVSILKATATSCLMRIKVPKDSIQPKQT
The following text describes a protein:
Function:
Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro) (By similarity). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (By similarity). Also, regulates spindle orientation during mitosis (By similarity).
Subcellular Localization:
Nucleus. Golgi apparatus, Golgi stack. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks. Localizes to centrosome during mitotic prophase and metaphase.
Sequence:
MAEERQDALREFVAVTGAEEDRARFFLESAGWDLQIALASFYEDGGDEDIVTISQATPSSVSRGTAPSDNRVTSFRDLIHDQDEEEEEEEGQRFYAGGSERSGQQIVGPPRKKSPNELVDDLFKGAKEHGAVAVERVTKSPGETSKPRPFAGGGYRLGAAPEEESAYVAGERRRHSGQDVHVVLKLWKTGFSLDNGDLRSYQDPSNAQFLESIRRGEVPAELRRLAHGGQVNLDMEDHRDEDFVKPKGAFKAFTGEGQKLGSTAPQVLNTSSPAQQAENEAKASSSILINEAEPTTNIQIRLADGGRLVQKFNHSHRISDIRLFIVDARPAMAATSFVLMTTFPNKELADENQTLKEANLLNAVIVQRLT
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane during regulated or polarized secretion. Involved in polarized cell growth and organ morphogenesis. During cytokinesis, involved in cell plate initiation, cell plate maturation and formation of new primary cell wall.
Subcellular Localization:
Cytoplasm, cytosol. Secreted, extracellular exosome. Note=Shuttles from the cytoplasm to the exocyst-positive organelle (EXPO) in the presence of EXO70E2.
Sequence:
MTERIRARGPRSSSVNSVPLILDIEDFKGDFSFDALFGNLVNDLLPSFLDEEADSGDGHGNIAGVDGLTNGHLRGQSAPLSSAPFFPEVDGLLSLFKDACKELVDLRKQVDGRLNTLKKEVSTQDSKHRKTLTEIEKGVDGLFESFARLDGRISSVGQTAAKIGDHLQSADAQRETASQTIDLIKYLMEFNGSPGDLMELSALFSDDSRVAEAASIAQKLRSFAEEDIGRQGASTAAGNATPGRGLEVAVANLQDYCNELENRLLSRFDAASQRRDLSTMSECAKILSQFNRGTSAMQHYVATRPMFIDVEVMNSDIRLVLGDHGSQPSPSNVARGLSALFKEITDTVRKEAATITAVFPTPNEVMAILVQRVLEQRVTGILDKILAKPSLMSPPPVQEGGLLLYLRMLAVAYERTQELAKDLRAVGCGDLDVEDLTESLFSSHKDEYPEHERASLKQLYQAKMEELRAESQQVSESSGTIGRSKGASISSSLQQISVTFVTEFVRWNEEAITRCTLFSSQPATLAANVKAIFTCLLDQVSVYITEGLERARDSLSEAAALRERFVLGTSVSRRVAAAAASAAEAAAAAGESSFKSFMVAVQRCGSSVAIVQQYFANSISRLLLPVDGAHAASCEEMSTALSKAEAAAYKGLQQCIETVMAEVDRLLSSEQKSTDYRSPDDGIASDHRPTNACIRVVAYLSRVLESAFTALEGLNKQAFLTELGNRLEKLLLTHWQKFTFNPSGGLRLKRDLNEYVGFVKSFGAPSVDEKFELLGIIANVFIVAPDSLPTLFEGSPSIRKDAQRFIQLREDYKSAKLATKLSSLWPSLS
The following text describes a protein:
Function:
May have a role in protecting cells from metalloid-induced proteotoxicity.
Miscellaneous:
MISCELLANEOUS: Present with 9520 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSDINEIEIPSRKDEIRQVTPKDPMHEIEDKSTYHAKIKKSDSGTVLGAIPLNSRSSSNSSVTSTGQSSRRVTKKTTKKKKKNACYFDTCSSAASKFIGDCNFCKGHFCSKHRLMENHACNGLTSCKEQLHQRNADKLEAEQTKAPKIQI
The following text describes a protein:
Function:
Plays a role in determining ER morphology.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.
Sequence:
MGFVLSKLRKEKSTEAVLEGLQTQIQALEKYMINTEERKRRFVTNFVGFTIGAYIVGFGLWWYFYFPPTMQECFMYLVPLLLFPIVIIFLRRLFTWYFQRKLNKNGDKLTRLKEDKRKILEQVMDKETYKVAVNLLERFGDKKQLRISGLPTGSTPNRPQVERSPLTVAAVARTSSAGGQQQQQRSLAPYTSVYRNNNNNQNTSLNSSVISTHSLGQMTSASPQLRAVQELRRRSPFPIVDDRSRSAIDRIVDFIVGDSPKDRFGMICKACHAHNGMLPKEEYEYTTFRCAFCNVLNPARKKRPVAPRLSLEAPSDTANKRNDSSESESSDDDSDKEPSARRALLQKLPSGGADMDATAETEDLAMETETIETGSAAPSTAEVAASS
The following text describes a protein:
Function:
Plays a role in odontogenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDRDPSEEDSMADLSFEAESPVLPPDELLEGLPSYDWLLQGRERQVFFPPLEALGRSQEPACWSSVLEHSRVPVVTEEVAREALLSFVNSHCCYSSAAAGNLIIQELRQQTLCRYRLETFSESRVSEWTFQPVTNHSVDGPQRGTSPRLWDMKVQVPPMFQEDTRKLQVPHSSLVKECHKCHGRGRYKCSGCHGAGMVRCSSCSGTKRKAKQPRRCHLCSGSGRRRCSTCSGRGNKTCATCKGERKLEHFVQLVIMWKNSLFEFMSPHHLHCPKELLAKARGENLFRDENATVYPIVDFPLQDISLASQRGIEEHSTMLASRARILQQMFFYSGGPFHHS
The following text describes a protein:
Function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis. May be involved in the synthesis of short and medium chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain.
Sequence:
MQSLRSSILKYVRVRVPLQVSLSQAEGRSALNILNLQIRTCSNSGSTDQDQIKEQVLNLVKKFDKIDATKVTESADFQKDLSLDSLDRVELVMAFEQEFSIEIPDEEADKLKCCADVAQYIISGAEKKAQESS