lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Putative FAD-dependent oxidoreductase.
Sequence:
MGAGSSVTPRDDMHLVIVGGGYAGSYFAVQMIKSGLCKVTLIDGRDAMFHSVGALRTVVDEDYFKYLFIPYDKMLGDSFTQGEVSDLDTASKTLTLKDGKTVTYTHLVIATGSSSSAFPSKMAVDTSVEEAKKLYSEYRKEVVAAKRVLMVGGGAVGVELAGEIKTEFPDKEVTIVSSSDFLVTTRTKPAFQKNIMDCLVKKNITVIMNDRVSNLDDLTLNKHVEGQVVKTTGGKELTADLVVPCTGITVNNQFFKQALAGALTESGTLEVNEYFQVKGHKEIYAMGDVTNVNEEKMAYTAKIHADLIKSNLLAEASDQTRKPYPGARVAMVVPVGRTGGAGQFMGMQLGDFAVKMFKAEDLFAKSIWSDLGMKLPQ
The following text describes a protein:
Function:
Putative 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR).
Subcellular Localization:
Nucleus.
Sequence:
MGIQGLLPLLKSIMLPINMKDLNGCSVAVDTYSWLHKGALSCSKELCKGIPTTKHIDYCMHRVNLLRHHGVKPILVFDGGPLPMKIEQENKRGRSRKENLSRAIEHETNGNMTAAYECYQKAVDISPSVAHDLIQVLKRENVCYVVAPYEADAQMTFLAISKQVDAVITEDSDLIAFGCPRIIYKMDKFGQGLEFRYSKLEQNKELSLTGFTKQMLLEMCILSGCDYLQSLPGMGLKKAHALIKKFESYDKVIKHLRYNTAAVSPMYEESFRKAIMTFQHQRVYDLMTKDLVHLSELSDCGSQDLDFLGPYPYIFIYDATLMLVRINLLYYGWRFFYDPFLNQENADTYRSSSRNSKRYTSYQVYISLSYRITIHQKECNAAELVDSRTYELNDFKVEGTASLEAKQKFRAPRTSPILPNSKVGVSSPWADSRKGADSYKFESLSMSSPDPLVDDDIHLKVSMCLESKSQGILVEEETENGLGLQSVPLQHPICKPCITLHKEHALDLSENKIRATKKKVIVRSSYFLKNNKKEDIQDDKSEINVVANDKSHSSIWENDYDSMPDAMNGAVVAAVKNAISQSSYFQSKPSARNGDTEQKENKRAILRSSYFQKNLANDNSQGNLDVAAEMEHTNPKSSSGDDCSERRLKKRKVTFIDTVQTDNASGECLEADTSGNQGDFNSDLDDSTKETKDGQGKFGSNISHLGHYSQISEKSMDNFVSVLSSFRYTSNGSRASGLRAPLKDIKNTSTNRSASNMDLSKFVYKPTKQKQLSARRKV
The following text describes a protein:
Function:
ATP-dependent DNA helicase and primase essential for viral DNA replication and recombination. The helicase moves 5' -> 3' on the lagging strand template, unwinding the DNA duplex ahead of the leading strand polymerase at the replication fork and generating ssDNA for both leading and lagging strand synthesis. ATP or dTTP hydrolysis propels each helicase domain to translocate 2 nt per step sequentially along DNA. Mediates strand transfer when a joint molecule is available and participates in recombinational DNA repair through its role in strand exchange. Primase activity synthesizes short RNA primers at the sequence 5'-GTC-3' on the lagging strand that the polymerase elongates using dNTPs and providing the primase is still present.
Domain:
The N-terminus zinc finger domain is essential for delivering the primed DNA template to the DNA polymerase. The central core domain contains the primase activity. The C-terminus region is responsible for the helicase activity and binds 1 Mg(2+)-dTTP.
Sequence:
MDNSHDSDSVFLYHIPCDNCGSSDGNSLFSDGHTFCYVCEKWTAGNEDTKERASKRKPSGGKPMTYNVWNFGESNGRYSALTARGISKETCQKAGYWIAKVDGVMYQVADYRDQNGNIVSQKVRDKDKNFKTTGSHKSDALFGKHLWNGGKKIVVTEGEIDMLTVMELQDCKYPVVSLGHGASAAKKTCAANYEYFDQFEQIILMFDMDEAGRKAVEEAAQVLPAGKVRVAVLPCKDANECHLNGHDREIMEQVWNAGPWIPDGVVSALSLRERIREHLSSEESVGLLFSGCTGINDKTLGARGGEVIMVTSGSGMGKSTFVRQQALQWGTAMGKKVGLAMLEESVEETAEDLIGLHNRVRLRQSDSLKREIIENGKFDQWFDELFGNDTFHLYDSFAEAETDRLLAKLAYMRSGLGCDVIILDHISIVVSASGESDERKMIDNLMTKLKGFAKSTGVVLVVICHLKNPDKGKAHEEGRPVSITDLRGSGALRQLSDTIIALERNQQGDMPNLVLVRILKCRFTGDTGIAGYMEYNKETGWLEPSSYSGEEESHSESTDWSNDTDF
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Sequence:
MALMMMTAVGPKLPLQRNKSRISRVIVPISLKATLSRTTERATACNVWEGQSLTFLHQRGLRHSPWSTFAVGPGLEASISDPSKNDIRLDNVKIVIESRDIDKITVRVDLTGEETQKAFDIVLTNLARTAPPIPGFRRMKGGKTSNVPKSFLLQMLGRDRVTKFLIQEIVGITIGDYVKKENLKVKSQFKTIQTAEELEAAFTPGSEFGFNAVVDVENSDSETTSSSAS
The following text describes a protein:
Function:
Mediates influx of magnesium ions. Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MFPGFDALPEVLRPVARPQPPNAHPVAQPPAQALVDCGVYVCGQRLPGKYTYAAALREVREIELTGQEAFVWIGLHEPDENQMQDVADVFGLHPLAVEDAVHAHQRPKLERYDETLFLVLKTVNYVPHESVVLAREIVKTGEIMIFVGKDFVVTVRHGEHGGLSEVRKRMDADPEHLRLGPYAVMHAIADYVVDHYLEVTNLMETDIDSIEEVAFAPGRKLDIEPIYLLKREVVELRRCVNPLSTAFQRMQTESKDLISKEVRRYLRDVADHQTEAADQIASYDDMLNSLVQAALARVGMQQNMDMRKISAWAGIIAVPTMIAGIYGMNFHFMPELDSRWGYPTVIGGMVLICLFLYHVFRNRNWL
The following text describes a protein:
Function:
May interfere with the nodulation process and inhibits nodule development.
Sequence:
MTQAQIQPVKLGTQGFEVSKLGFGCMGLTGAYNDPLQEQDGISVIKYAFSKGITFFDTADVYGANANELLVGKALKQLPREKIQIATKFGIASRGFPDMKIEGSPEYVRSCCETGLKRLDVEYIDLYYQHRVDTSVPIEETVGELKKLVEEGKVKYIGLSEASPDTIRRAHAIHPITAVQIEWSLWTRDIEEEIVPLCRELGIGIVPYSPLGRGFFGGKGVVENVPTNSSLKAHPRFQAENLDKNKNIYERIEGLAKKHQATPAQLALAWVLQQGEDVVPIPGTTKIKNLDQNIGALAVKLSEKDLREIFEAVPIGDVAGGRYYNGLDHFSWKYANTPPKDSKIST
The following text describes a protein:
Function:
D-galactose-specific lectin, binds the T-antigen structure Gal-beta1,3-GalNAc (Thomsen-Friedenreich-antigen-specific lectin). Potent and selective stimulant of distinct T- and B-cell functions. Shows a unique ability to specifically recognize IgA-1 from human serum.
Sequence:
GKAFDDGAFTGIREINLSYNKETAIGDFQVVYDLNGSPYVGQNHKSFITGFTPVKISLDFPSEYIMEVSGYTGNVSGYVVVRSLTFKTNKKTYGPYGVTSGTPFNLPIENGLIVGFKGSIGYWLDYFSMYLSL
The following text describes a protein:
Function:
Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.
Subcellular Localization:
Cytoplasm.
Sequence:
MQPFSYAYVSLLTTESYLPGALVLAASIRQTSTLYPLVIIVSQDHIGHAAIQTLLTVYDKVIPVQQLLTNSNDNLNLLGRPDLFATFTKLHLWNPDILPYSRIVFLDADTLVQRNIDCLFQYVEQESVVFAAAPDAGWPDCFNSGVFVTKPCAVLFHQLLEYAANNTSFDGGDQGLLNSFFSSWSCESPVNPRTGRLPFTFNVTPSAFYSYLPAFHHYSANISIVHFIGSTKPWKMSRFFDGSIMPFGEMSDGVKDLMASWWAVFDKNELHLVLRTFKLDRDWSQYQVPNQTPGMFEAIGSFASSGFQTSALGALPNSASEFGRYRVDWNDRESRSAMAVSRSRSPAKRRSRHSKSPRRGESLSKSPTKLNSSHGKRTSPLDSRLGGSGKNGSPVKSEAASGSHQHGAGHLDAITIASATKSSMSYTTPTDDFANYRVSWSRHELRGQAAQRSPKSDQMNSKSSDSENDSSYLIFTSDEASSSTGYSSTADLDSQFETETLKIVNPLPLPHHIHHKLDALSIKPTTLDNTVSDPQSLATSSTKKTGENRK
The following text describes a protein:
Function:
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Subcellular Localization:
Cytoplasm.
Sequence:
MKILINKSELNKILKKMNNVIISNNKIKPHHSYFLIEAKEKEINFYANNEYFSVKCNLNKNIDILEQGSLIVKGKIFNDLINGIKEEIITIQEKDQTLLVKTKKTSINLNTINVNEFPRIRFNEKNDLSEFNQFKINYSLLVKGIKKIFHSVSNNREISSKFNGVNFNGSNGKEIFLEASDTYKLSVFEIKQETEPFDFILESNLLSFINSFNPEEDKSIVFYYRKDNKDSFSTEMLISMDNFMISYTSVNEKFPEVNYFFEFEPETKIVVQKNELKDALQRIQTLAQNERTFLCDMQINSSELKIRAIVNNIGNSLEEISCLKFEGYKLNISFNPSSLLDHIESFESNEINFDFQGNSKYFLITSKSEPELKQILVPSR
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB41.
Subcellular Localization:
Secreted. Note=Following 6 weeks of nutrient starvation.
Sequence:
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDDRIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK
The following text describes a protein:
Function:
Involved in translation.
Subcellular Localization:
Cytoplasm.
Sequence:
MFKKFTVKEDVASNTIIKSSTQRAIRAKLSQQFPALNHPILLLDHPQNEQQNDSQSSAPTVSPETPELTLLEFLWPKKESLNLLKCREHVSILVCKKTPLFFQHFDGPYFPTLKLLHQYPMLLPTVQVDRGAIKFVLSGANIMCPGLTSAGARLPAELPLHTPVAVLAQDKSLPCAVGFTQKSAADMRSQNKGVGVDNVHWLGDDLWLIDEI
The following text describes a protein:
Function:
Formins play an important role in the nucleation of actin and the formation of linear actin filaments.
Domain:
DRFs are regulated by intramolecular GBD-DAD binding where Rho-GTP activates the DRFs by disrupting the GBD-DAD interaction; The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
Sequence:
MILSITFQLDPISNNSTSLSNSIDNRSSINVTALQMQQGSKTYNLDQNSSYKTVFLAICQLFGIKESSAQDYCLQLESSKKYLNWPPQSDESKTKHIVKQLYESGETALVLQLNPTYRSSKWVKALNDSETNEKDIMFHLKYKLQENEFAESFIEQNGMEGILRMVTNGKGNAQTYSLASLRACLEYVSAMEIITKTPHLVKQLFSLVDSNVVGVCRGALELLFVLCDFRKEEGFKSVHLAAKGTAVAQGKKPYLNVIKLLDSGDLETKINAFTLLNVLLSNCPTDEKVGKLCKKWGELGLDDKLRSLTSIQQQEFQIQLEIYEETSGVNLRTKASRLEAICNRLKSKLTEYEAQQPLIAILKEELKLAQQLIKEASTDRVFLSSHPMQRYLGPTIQSYPADLSFLKTTAAERDKINEFEKKILAINEQLRQETKLSEELKNQVLANKKQFDSTIAELNEENQRLTQVEVKFKLQQSISPSQDSSNNQKASSSSSNTSTLNDSDIQSIQSSLKEATLEIERLKLAIEEKMPPNEAQQIFSQSLITTAAFTPTSPDISNDGQPISGGGAPPPSPSPPPPISGGGAPPPPPPPPPPPSGGGAPPPPPPPPPSGGKKAGAPGAPPTGPAAIQPNKPVINPSSKMKPLYWKRIILPPSNRNESIWDQVLEPTFDSKDFENLFCAKKKAVDSSLSTNPSSTTGKEGEKVKLVSLVDIKKSNSIAFMLAKIPTAEGLKKAIDTVDNSILGKEIIKTLITNVPTEQDYQLIKGSEIHESKLDKPERWILEIYGFPMMKERLVAWLFQLEYQEMYNNIIQILEKLQNAIKDTKSSDSLKKILGIVLVLGNYMNGGSGRGQADGFTLEILDSLATSKDVENKTSLLDYVSKISMEKYPKTMNVAQELDSLKLVQLSISDMSTDINDLEKQFNISKNNCKKVLEANIPSSSKFQSTIGSFLEKTEIDIKNLKENQKNIVDSFIQLVEFFGYPKSYATTASCQQFFNSIYSFSLLFSKQCQKIEKEREALAKASGDNGAVQNKKIAGGADPLAALANAIKLGQTGLRKRPGPENSSGGSQLNLNK
The following text describes a protein:
Function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MASIAASASISLQARPRQLAIAASQVKSFSNGRRSSLSFNLRQLPTRLTVSCAAKPETVDKVCAVVRKQLSLKEADEITAATKFAALGADSLDTVEIVMGLEEEFGIEMAEEKAQSIATVEQAAALIEELLFEKAK
The following text describes a protein:
Function:
Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTFPNVKFIGNKRVLSIQSSVSHGYVGNRSATFPLQLHEWEVDVVPTVHFSNHLGYGATRGSACIPEEVHDLLNALLQDNGIVYDAILTGFVPNHDIIQVIFDCVLAYKKDHPKVLWLLDPVMGDQGKMYVDTNVISTYKAMIPHAFAITPNAFEVEILTDIVIHTQMDAKRGLEKIYQLYGIQNAIITSFEVEESPGTLFCMGYSCEHGKPQLFLYQFPSLSGVFTGTGDLFSGLLLAKYREELDKRKHQQSDETKQTKRPTVLACAVGQVLSCMHTVLVNTKTYADEILLEDPKIASDEFLLSNARELRLIQSRTALLSKKSIYEAEFLPGFEEGEDV
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular Localization:
Nucleus.
Sequence:
MTEVIWGTTIQYKEVKKTIQQFLSSPKYHLLLENSYETHFIDIYLPDVLEFDKNLHKCTLEYPTQILHLYDLVASEMGYEEVEVRVFGLSQVKRIRGLSPSDIERLVSVRGMVTRVGNIIPSMKSGYFKCTECNYNVDLVVDVRGTLTVPAKCPHCKKTGTLQLIHTLSYYIDKQIIRLQESPEAIPAGETPQTLHLLAFDSLVDSAKPGDRIEVTGVYRADPVKIGVSQRTVRAVFRSYIDVIHIKKYSKETEVDIDFTTLINDDWYERLTRSVAPSITEMDDVKKGLLCQLFGGSAKTLQDNQKLRGDINILMLGDPGTSKSQLLTFMHKVAPRGMYTSGRGSSAVGLTAFVGKSEEGGTVLESGALVMSDKGLCCIDEFDKMTEMTRSVLHEAMEQQTISVAKSGIVCSLNARTAILASANPKESRYNPKLSVLDNIQMPPSLLSRFDLIYLILDQPNPERDRKLARHIISLYWGHEIKTDALDISTFSSFVRYARKRCKPVLTDNARTELVKGYLEMRKIGSENKTHKTISATTRQLESLIRISEALAKMQLREKVEARDVKEAIRLVTSAIHQAATDPETGIVDYDLIQTTKGYREQSVIEES
The following text describes a protein:
Function:
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Sequence:
MTAHEPAVDMASPLEQGISGEKAVPTVIERYLSDEQVQQFMEQGVLVVPNVLTPQEVAEARRGLHGELAKYGVDHKSLETTGDNLKKLSSTGGAGGILDLFYPSWRLKVAEHEKVFAAMTDLWEATYAHNHPDFQHPFGDFDGKRGYMYINRVCYRVPDAISKKFAQKKSRPMQRSLTPHWDCCPTKMFDSGKDTPRWRPIQCITVLTSNTEPNTGGFEAVPGFHKEFVEYAAKHMPEVLTAVPLTAPVRRPQVCLGDFSPLRMQEDREVIDRYQHIGCEAGSVIFFDWRIPHANSYKHVGSIPREVVYTGFIPDTPMNRRYVQEQLRRYKARLLPADHWQKDDVHARVAEDFSAHHFSSLGSRLIALHPCPDNSKTHVVVGMSGGVDSSVAALLLKRQGYRVTGVYMKNWDPSDEEGESACPVDSEYLDVQKVCEQLGIEAQMVNLVQSYWNSVFEPCLEGFEEGLTPNPDILCNREIKFKAFTEYAQKIGADYVATGHYAALRRAEDGGPLNLCAAVDETKDQSYFLSSVDGRAFANVLFPLGGMCKTEVRRIAASEGLCTATKKDSVGICFIGKRNFADFIHQYIQRQEGFFYTVDGEKMYPHHGFTAYTVGQGARLQGMSAKWFVV
The following text describes a protein:
Function:
Membrane-anchored forms may play a role in cellular adhesion.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Secreted.
Sequence:
MILMQEVIEAAGQACSCMCVACILPEVETCRELENAGEAVSLRGPPGSALPQPGHTPSEAVWSEIMALQTAQRPLGSCGTPTHGSLLLLLLSLGWLPPPGAQAADTGLGFVTPWLQRPTRDPSWQQPELTVVLQRAQRSTKTKACALSQKACPPEQKATVVDENLVFYEEWELEACVDAALLDAQMDRVNAIPFTHQQLEIFRCKLNQFYPQGYPESLIRRLRYFFYAVTPEDIYKWNVTSPEIVKYLLKISEGRRMDAQVAVLIARYLVGGGQMDKATLDTLAAFRPTYLCLLSPEQLDSMPHNVVWAAGPQDLDTCRPPQMDALYSKARIAFQNMSGSEYFARIKPYLGGAPTEDLQALSRQNIHMDMATFKKLRTEAVLPLTIAEVQKLLGPNLAGLKAEEGNSPVRDWILRQPQDDLNSLGLGLRGGIPNGYLVLDLSFREALSGGPRLLGPGPGLTMILTLLLAEILN
The following text describes a protein:
Function:
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MSDVAVAETPAVKTPTKAPKANATKVPKVKTAAAHPPFINMVTAAISSLKERKGSSKIAILKYITANYKLGDQVKKINSNLRSALKKGVASKALVQTVGTGATGRFRVAEKTAATAKKPTVKKAATGEKVKKTVVKKTVAKKTGDKVKKAKSPKKIAKPAAKKATKSPSKKVAPKKAAAKPAKKTAALKA
The following text describes a protein:
Function:
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Subcellular Localization:
Cytoplasm.
Sequence:
MADREEILRNVMDEVSPGAVGVVVADSTGLVISSRGTMGKESAAMGTQLISLAAELDPRERKPPVIQLQSESERMTETSLTLEFTGGSEFLVGNQKMHQVSISGEELTIRSVLIWLKENLLKNCDRIDLLLEGDAVRPGVLVLVNDTDWELLDEEKTVLKNGDRVTFISTLHGG
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Sequence:
MDGLEQQKLAKQQELAALKRITALTDQMRTELDEMSIEVSKINKNAESVANVMANWDSIRKYISEASLGLLRYAEGDYQVGAWDGKENKSDKSNADKSYQSDDEHKTEPLPEALVRISVANNEESRK
The following text describes a protein:
Function:
Involved in protein precursor import into chloroplasts.
Subcellular Localization:
Plastid, chloroplast inner membrane; Multi-pass membrane protein. Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MRSLASTCDYYWPVRPVLSTKVKLQSQIFEGRQPLSRLSSTSTSLFGKDRSVLPPRTGRHKCPAPPKVYLDYPFSIPYPKIVKKPEWWWRTLACVPYLMALQISDTAFYFQPLMEHYEQFEWPHFFRYHVMMGLLLENVLQIVWYASNFAPLIHYGGRFGMYYWAIVGSAFIFLLMECVRCAVAGIYANIPFISDAAYIHTPYVKGDD
The following text describes a protein:
Function:
Self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer. Arc2 protein is released from cells in extracellular vesicles that mediate the transfer of mRNA into neighboring cells.
Subcellular Localization:
Extracellular vesicle membrane. Note=Forms virion-like extracellular vesicles.
Domain:
The protein is evolutionarily related to retrotransposon Gag proteins. It contains structural elements found within viral Gag polyproteins originated from the Ty3/gypsy retrotransposon family and retains the ability to form virion-like capsid structures that can mediate mRNA transfer between cells. Tetrapod and fly Arc protein-coding genes originated independently from distinct lineages of Ty3/gypsy retrotransposons.
Sequence:
MTQMSDEQFRIFIETIKSLGPIKEEPPSKGSFSNCTVRFSGQRDHDAVDEFINAVETYKEVEGISDKDALKGLPLLFKSIAVVWWKGVRRDAKTWSDALQLLRDHFSPTKPSYQIYMEIFETKQSYDEVIDSFICKQRALLAKLPEGRHDEETELDFIYGLMQPKYRESIPRHEVKTFRELLDRGRTVERTRH
The following text describes a protein:
Function:
Probable transcriptional factor. Binds to the promoter of the SQUAMOSA gene.
Subcellular Localization:
Nucleus.
Sequence:
MLDYEWGIGEETTQETDQNDQFFDPFVNPHAHFPPISNHPDQRQQQQQIQNHQFPQFQTTPNNNHFNSLYNPHTNDVPYSQTHHTSMLSLQPTGSAGFNMVLPKSEPQFVGGIDFTNTSRIGLNLGGRTYFASSEDDFVNRLFRRTRAVEGGSVNSPKCQADGCNADLTHAKHYHRRHKVCEFHSKAATVIAAGLTQRFCQQCSRFHVLSEFDNGKRSCRKRLADHNRRRRKNQQVINKKQPQFES
The following text describes a protein:
Function:
Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), a coenzyme for methylmalonyl-CoA mutase, therefore participates in the final step of the vitamin B12 conversion. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA.
Sequence:
MLTYRSNMASFVFRTTLLRCAARSVATKYRTPNRWRSEQSYATAEDNKGPKIYTKTGDKGFSSTFTGERRPKEDHIFEALGNTDELSSAIGLAREFCLEKGHTFIHQLDKIQCILQDVGSNIATPRSSARDSHIKKTKFTSQPIADLETWIDNFTNELPPLTNFILPSGGKSSAALHLARTVCRRAERSVAPIVRSGEADQDVAKFLNRLSDYLFTVARYAAMKEGNEEKIYKRPE
The following text describes a protein:
Function:
Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division.
Subcellular Localization:
Periplasm. Note=Tightly associated with the murein sacculus.
Sequence:
MEKAKQVTWRLLAAGVCLLTVSSVARADSLDEQRSRYAQIKQAWDNRQMDVVEQMMPGLKDYPLYPYLEYRQITDDLMNQPAVTVTNFVRANPTLPPARTLQSRFVNELARREDWRGLLAFSPEKPGTTEAQCNYYYAKWNTGQSEEAWQGAKELWLTGKSQPNACDKLFSVWRASGKQDPLAYLERIRLAMKAGNTGLVTVLAGQMPADYQTIASAIISLANNPNTVLTFARTTGATDFTRQMAAVAFASVARQDAENARLMIPSLAQAQQLNEDQIQELRDIVAWRLMGNDVTDEQAKWRDDAIMRSQSTSLIERRVRMALGTGDRRGLNTWLARLPMEAKEKDEWRYWQADLLLERGREAEAKEILHQLMQQRGFYPMVAAQRIGEEYELKIDKAPQNVDSALTQGPEMARVRELMYWNLDNTARSEWANLVKSKSKTEQAQLARYAFNNQWWDLSVQATIAGKLWDHLEERFPLAYNDLFKRYTSGKEIPQSYAMAIARQESAWNPKVKSPVGASGLMQIMPGTATHTVKMFSIPGYSSPGQLLDPETNINIGTSYLQYVYQQFGNNRIFSSAAYNAGPGRVRTWLGNSAGRIDAVAFVESIPFSETRGYVKNVLAYDAYYRYFMGDKPTLMSATEWGRRY
The following text describes a protein:
Function:
Converts 2-amino-4-deoxychorismate (ADIC) to 3-O-enolpyruvoylanthranilic acid (OPA). Involved in the biosynthesis of the benzoxazolinate moiety of the enediyne antitumor antibiotic C-1027.
Sequence:
MSAQLKILAINGSERDGNTADVLRHAARVAENRGVDFEAVDLRSIRMERCGPCGDCNDRPVACTLADGVPEVVAKMVAADGIIFAAPVHGFGTASLMQTFIERAGVGYLRFDRPLSNKVAGIISVARRYSAGEVWAQLTVNALLNRMILVGSGFPATVHALHRGDALKDEEGLTNVSRLVERMTDMIELLDEHRRLTGRSDVLASNEVNERVGLALNELQAQP
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
Subcellular Localization:
Peroxisome membrane; Single-pass membrane protein.
Sequence:
MATQSPSPQNLGGEIEQTENVDQHNRGEELGKQSSDTSVFVNSEPLREEQIQNAVKFLSHPKVRGSPVIHRRSFLEKKGLTKEEIDEAFRRVPDSPPSVQTAGINQDGQLKPSSNIQQQGQPQALQLTVPASTGVTTTLGTLSRRSFHWSHALIAVGLLAASGAGTVIVIKNSILPRLKSWIRNVVLEEDHDQSKRTGSKPTLAEEAAQAAKAAAVAAADIAKASQELLSSKIEEKRYFVEVVNLLDKQVQEMKLMTNAIGRLEASGGLSVSKQEDRLVTQTGSKTQQLIVNGKSDYESRSVRSSSPPVSVEPSSAPHPKSYMEIMAMIQRGEKPSNIREIDDSAPNPYQQPSNPRLAPRAKPWEVSQVQNTSTQVLPYQVNGKIQDNGDNTVPWWQTKNVRIKEIDNEIEYNGAPAASSPQPVQRAWVPPQPPPIAMPEAAEAIRRPKQGSPKGSDTG
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Subcellular Localization:
Plastid, chloroplast thylakoid lumen.
Sequence:
MILTMKLVHPLHHSLSSSIPFPSRKRQSKPYRCSLPSPGCEKVIRTETVLPPAPVSCEGRRVLLGCLLATASGILSTGSAEAVSTSRRALRASKLPESDFTTLPNGLKYYDIKVGNGAEAVKGSRVAVHYVAKWKGITFMTSRQGLGVGGGTPYGFDVGQSERGNVLKGLDLGVEGMRVGGQRLVIVPPELAYGKKGVQEIPPNATIELDIELLSIKQSPFGTPVKIVEG
The following text describes a protein:
Function:
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
Subcellular Localization:
Nucleus.
Sequence:
MTQLYIGLCPELTAPLVEKFRDAGIRTVVDLLNCEREDLAGRTGLPYSDVIRIRRSLVALFAPTPQDGASLYDKFLATTAVFSTGSRKVDDVIGGGVFTGQITEIVGASTSGKTQLCHSLTAHAVIDSHFGVLYVDTLSCFSAERIRQILSSAQQSAKPDQLMQRVCHIGIRDIGELVQLVDQIRNSLERRANSELASIKMIVVDSLKAAVSPVLTGDQYVEGLGLLAHLAIAFQYIAARFRVAVVVTNDVVTGPNGMMKPALGKYWADVPSLSLEVSLVDDLYSDLRRLLVAKSSRAVLGSSVKFRIVNKGVTSAGIS
The following text describes a protein:
Function:
This enzyme has both RNase and DNase activity.
Miscellaneous:
MISCELLANEOUS: Present with 3870 molecules/cell in log phase SD medium; MISCELLANEOUS: The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MCSRILLSGLVGLGAGTGLTYLLLNKHSPTQIIETPYPPTQKPNSNIQSHSFNVDPSGFFKYGFPGPIHDLQNREEFISCYNRQTQNPYWVLEHITPESLAARNADRKNSFFKEDEVIPEKFRGKLRDYFRSGYDRGHQAPAADAKFSQQAMDDTFYLSNMCPQVGEGFNRDYWAHLEYFCRGLTKKYKSVRIVTGPLYLPKKDPIDNKFRVNYEVIGNPPSIAVPTHFFKLIVAEAPTANPAREDIAVAAFVLPNEPISNETKLTDFEVPIDALERSTGLELLQKVPPSKKKALCKEVNCQIVVRDFSNAAIKQSKDVKLLPPPKKRN
The following text describes a protein:
Function:
Regulatory subunit of pyrophosphate--fructose 6-phosphate 1-phosphotransferase.
Subcellular Localization:
Cytoplasm.
Sequence:
MDADYGIPRELSDLQKLRSHYHPELPPCLQGTTVRVELRDATTAADPSGEHTIKRFFPHTYGQPLAHFLRATAKVPDAQIITEHPAIRVGVLFCGRQSPGGHNVIWGLHDALKVHNPKNILLGFLGGSEGLFAQKTLEITDDVLATYKNQGGYDMLGRTKDQIRTTEQVNAAMAACKALKLDGLVIIGGVTSNTDAAHLAEKFAETKCLTKVVGVPVTLNGDLKNQFVEANVGFDTICKVNSQLISNVCTDALSAEKYYYFIRLMGRKASHVALECTLQSHPNMVILGEEVAASKLTIFDITQQICDAVQARAEHDKNHGVILLPEGLIESIPEVYALLQEIHGLLRQGVSADKISSQLSPWASALFEFLPHFIRKQLLLHPESDDSAQLSQIETEKLIAHLVETEMNKRLKEGTYKGKKFNAICHFFGYQARGSLPSKFDCDYAYVLGHVCYHILAAGLNGYMATITNLKNPANKWHCGASPISAMMTVKRYGRGPGKASIGVPALHPATVDLRGKSYELLSQNATKFLLDDVYRNPGPLQFDGPGADAKAVSLCVEDQDYIGRIKKLQEYLDKVRTIVKPGCSQDVLKAALSAMASVTDILSVISSPSSVSTPF