lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
Subcellular Localization:
Nucleus.
Sequence:
MFGGAMPMPMPVPAAGYGGPMPMPMGASVGLGGGVVPEILNTTPGVTGEGRRQAVAATRRRTAAGQEGRGEMCQRMRYIMFEIDEHNGRFLADRPADQPFQFLDVCCCPGGFSTYSLEAGKAPRKGIGLSLPPMYGGHLPAIPERTDNYYLHFVDVTTIAATVRVGDMGVGTPGCPQPALRLDAALHDPPSNACQLVILDGSFLGGKDWIHKETSLTDADNPAFNVYSSNAAAHKALLVAQLVVMANNLARGGLLVLRLNMFPDMFTVGVLGLLRQVFAGDVASYKPRSCHVHVGSYYLVCTNFDPVRAYQMQWVPRWYECLTRMRAGGPAPRFVPFPGFHLDSAPAMQVWTRAMYAYHVHLWRFLKLVEVAMEEKALLDKRLAQRPRTGRFTNTCGRIFANVRCTAGERCNSAHSFAELHPFVQKAFREPRGFLHQPGSLALLSAPVVAYDPLPETLLELRQQAHMQNVLRAQAVADSQRARLHAAAAAGAAAAAAAGGAGGPGGGYAGGSGGPNHQNHQNSNMLGMAVGGGYDEAVQLGMAGEWVHGLMRGTRDEAGEAGGEDALSLFMRTADDPNVVLEGGFEDPEPAPGAVPHPGGFGRGAAAGGWAGPGGGVAGEGEGGGKDGGGAGEVGGGGGGGGSGSGAAAPAAPAEEPDDWELELAGLTGAAGGGEAAAATGAKAGGGGGGGSKPRPRAGSGAAGGGSAAAMRPELLQMSGYQPRLGLLAIEVEDDETLSAMCEYLGW
The following text describes a protein:
Function:
Involved in the organization of the outer spore wall layers and especially in the assembly of the chitosan layer.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MGFVDFFETYMVGSRVQFKQLDISDWLSLTPRLLILFGYFYLHSFFTAINQFLQFINTNSFCLRLHLLYDRFWSHVPIIGEYKIRLLSRALTYSKLKIIPTLDKVLEAIEIWFQLHLVEMTFEKKKNVQIFITEGSDDLNFFKDSKFQTTLMICNHRSVNDYTLINYLFLKSCPTKFYTKWEFLQKLRKGEDLAEWPQLKFLGWGKMFNFPRLDLLKNIFFKDETLALSSNELRDILERQNNQAITIFPEVNIMSLELSIIQRKLHQDFPFVINFYNLLYPRFKNFTTLMAAFSSIKNIKRKKNRNNIIKEARYLFHRELDKLVHKSMKMESSKVSDKTTPPMIVDNSYLLTKKEEISSGKPKVVRINPYIYDVTIIYYRVKYTDSGHDHTNGDLRLHKGYQLEQISPTIFEMIQPEMESENNIKDKDPIVVMVNVKKHQIQPLLAYNDESLEKWLENRWIEKDRLIESLQKNIKIETK
The following text describes a protein:
Function:
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm.
Sequence:
MRSPHRDAIRTARGLVVKVGTTALTTPSGMFDAGRLAGLAEAVERRMKAGSDVVIVSSGAIAAGIEPLGLSRRPKDLATKQAAASVGQVALVNSWSAAFARYGRTVGQVLLTAHDISMRVQHTNAQRTLDRLRALHAVAIVNENDTVATNEIRFGDNDRLSALVAHLVGADALVLLSDIDGLYDCDPRKTADATFIPEVSGPADLDGVVAGRSSHLGTGGMASKVAAALLAADAGVPVLLAPAADAATALADASVGTVFAARPARLSARRFWVRYAAEATGALTLDAGAVRAVVRQRRSLLAAGITAVSGRFCGGDVVELRAPDAAMVARGVVAYDASELATMVGRSTSELPGELRRPVVHADDLVAVSAKQAKQV
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone; Histone methyltransferase. Methylates 'Lys-79' of histone H3.
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Subcellular Localization:
Nucleus.
Sequence:
MGEKLELRLKSPVGAEPAVYPWPLPVYVSVLAENPGDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNATTPTKVPESKAAATEAPADSGAEEEKSGVATVKKQSPSKARKKKLNKKGRKMAGRKRGRPKKMSAASADRKSKKSQSTLDLLHSPPPAPPSASPQDAYRAPHSPFYQLPPSTPLHSPDPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKANLQQLLDQEKEKNTQLLGTAQQLFSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEKDNSELRSQSLRLLRARCEELRLDWSTLSLENLRKEKQALRSQISEKQRHCLELQISIVELEKTQRQQELLQLKSCVPPDDALSLHLRGKGALGRELESDAGRLRLELDCAKLSLPHLSSMSPELSMNGHAASYELCGAASRPSSKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSGLALPDYTRLSPAKIVLRRHLSQDHTGASKAATSEPHPRPEHAKENSLPYQSPGLSNSMKLSPQDPPLASPATSPLTSERGSEKGVKERAYSSHGETITSLPVSIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVPQPRDSSSTLEKQIGASTHGAGGAAAGSRSLTVAPTGFYAGSVAISGALASSPAPLASGMESAVFEESSGPSSLFGTMGSRSTPPQHPPLLPQSRNSGPASPAHQLAASPRLSVTTQGSLPDTGKGELPADPAFSDPESEAKRRIVFSISAGASSRQSPSTRHSPLTSGTRGDCVQSHGQDSRKRSRRKRASAGTPSLTTGVSPKRRALPTVAGLFTQSSGSPLNLTSMVSNINQPLEITAISSPESSLKSSPTPYQDHDQPPVLRKERPLGPTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLVGRKPVPSGEPVNSSKWKSTFSPISDLGLAKAMDSPLQASSALSHSPLFSFRPSLEEPAAEAKPSTHPRKSFAGSLAAAEGPSPGTNPPNSLAFSGGLAADLGLHSFNDGASLSHKGPEVAGLSASLSFPSQRGKDSTTEANPFLSRRQPEGLGGLKGEGNASKESGESLPLCGPSDKVSLPHGSRASKGRDRELDFKGGHNLFISAAAVPPGGLLGGPGLVTVASSAGSATPSAQAPRPFLSTFAPGPQFTLGPMSLQANLGSVAGSSVLQSLFSTVPAAAGLVHVSSTATRLTNSHTMGSFSSGVAGGTVGGN
The following text describes a protein:
Function:
Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).
Subcellular Localization:
Cytoplasm. Secreted, extracellular space, extracellular matrix.
Sequence:
MRESPGAARARRESPPQANNPERLCKHRGINEASWTMKCVLSCIPEPTVVMAARALCVLGLVLALVSSSSAEYVGLSANQCAVPAKDRVDCGYPQVTPEQCNNRGCCFDSSIVGVPWCFKPLQEQGECSF
The following text describes a protein:
Function:
Required for pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MEVETSGKPIDSVLERVLCMNILSSDYFKELYRLKSYHEVVDEIYNQVDHVEPWMTGNCRGPSTAFCLLYKFFTMKLTVKQMQGLLNHRDSPYIRAVGFLYLRYVGDSKSLWGWFEQYITDDEEFSPSSSGRMTTMGLFVRDLLLDQLLQVGGATSNWHVRHFQQAPVNLGISQQAMKWAFSFHRLLRIFLFANSSYYFDTLFPRIPVPVMRQIVSNLERLKMSTQSSGVTGTGSRHATEDTARRPPSVKAALSVSFGQRAPHRASTRDSSPVRRNVPIAREFQAHGDDHRLSQHESKRHIKDDEEDRNKSRERERFRSNARLRDRIGDRERERAPEVNRARERDWEESRDRNKQSDRSRDRDCDHTRVRQRHREWESSRSRKRERTCDDSGHLSYGSGNRCTARSPERSHSGDKETGSNKLEDGAARKHSLGKFQGGVHHNLPDRGRASVLTSFARLQDVYGTGSERGHEEQRRPADVKERNCEDVIHLGGPTWR
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MNHYFLKYWILMVPLIWPCLKVAETLKIEKAQRAVPSLGRAKRGWVWKQFVVPEEMDTIQHVGRLRSDLDNGNNSFQYKLLGTGDGSFSIDEKTGDIFAMQKLDREKQSLYILRAQVIDTTIGKAVEPESEFVIRVSDVNDNEPRFLDEPYEAIVPEMSPEGTFVIKVTANDADDPTSGYHARILYNLEQGQPYFSVEPTTGVIRISSKMDRELQDTYCVIIQAKDMLGQPGALSGTTTISIKLSDINDNKPIFKESFYRFTISESAPSGTTIGKIMAYDDDIGENAEMDYSIEDDESQIFDIVIDNETQEGIVILKKKVDFEHQNHYGIRVKVKNCHVDEELAPAHVNASTTYIKVQVEDEDEPPTFLLPYYIFEIPEGKPYGTMVGTVSAVDPDRRQSPMRYSLIGSKMFDINGNGTIVTTNLLDREVSAWYNLSVTATETYNVQQISSAHVYVQVLNINDHAPEFSQLYETYVCENAESGEIIQTISAIDRDESIEDHHFYFNHSVEDTNNSSFILTDNQDNTAVILSNRAGFSLKEETVFYMIILIADNGIPPLTSTNTLTIQVCDCGDSRSTETCTRFIFLILALKQRRKETLFPEKTEDFRENIFCYDDEGGGEEDSEAFDIIELRQSTVMRERKPRKSRSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDSSAPPFDSLQTFAYEGTGSSAGSLSSLGSSVTDQEDDFDYLNDLGPCFKRLANMFGSAVQPDN
The following text describes a protein:
Function:
Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins. Involved in the degradation of free oligosaccharides in the cytoplasm (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MAAAPFLKHWRTTFERVEKFVSPIYFTDCNLRGRLFGDSCPVTLSSFLTPERLPYEKAVQQNFSPAQVGDSFGPTWWTCWFRVELVIPEVWVGKEVHLCWESDGESLVWRDGEPVQGLTKEGEKTSYVLSERLHAADPRSLTLYVEVACNGLLGAGKGSMIAAPDPEKMFQLSQAKLAVFHRDVHNLLVDLELLLGVAKGLGEDNQRSFQALYTANQMVNICDPAQPETYPAAEALASKFFGQRGGESQHTIHATGHCHIDTAWLWPFKETVRKCARSWSTAVKLMERNTEFTFACSQAQQLEWVKNQYPGLYAQLQEFACRGQFVPVGGTWVEMDGNLPSGEAMVRQFLQGQNFFLQEFGKMCSEFWLPDTFGYSAQLPQIMQGCGIKRFLTQKLSWNLVNSFPHHTFFWEGLDGSQVLVHFPPGDSYGMQGSVEEVLKTVTNNRDKGRTNHSGFLFGFGDGGGGPTQTMLDRLKRLGNTDGQPRVQLSSPGQLFTALERDSGQLCTWVGELFLELHNGTYTTHAQLKKGNRECEQILHDVELLSSLALARSAQFLYPAVQLQRLWRLLLLNQFHDVVTGSCIQLVAEDAMNYYEDIRSHGNTLLSAAAAALCAGEPGPKGLRHYQHTALEAHRSVGTTQGLVGLTRLALVTVPSIGYAPAPTPTSLQPLLPQQPVFVMQETDGSVTLDNGIIRVRLDPTGCLTSLVLVASGREAIAEGALGNQFVLFDDVPLYWDAWDVMDYHLETRKPVRGQAGTLAVGAEGGLRGSAWFLLQISPNSRLSQEVVLDVGCPYVRFHTEVHWHETHKFLKVEFPARVRSPQATYEIQFGHLQEADPQQHSWDWARYEVWAHRWIDLSECDFGLALLNNCKYGTSVRGNVLSLSLLRAPKAPDVTADMGRHEFTYALMPHKGSFQEAGVIQAAYNLNFPLLALPAPGPAPDTTWSAFSVSSPAVVLETIKQAEKSHQHRTLVLRLYEAHGSHVDCWLHTSLPVQEATLCDLLEQRDPTGHLSLQDNRLKLTFSPFQVRSLLLVLQPPAN
The following text describes a protein:
Function:
Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
Subcellular Localization:
Mitochondrion.
Sequence:
MALKFVIHEPKAKLLFTPKEFFNTLNDIFKNSQNRIVISCLYMGIGELEKELIDSIKKNVNIKDLKVDILLDRQRGTRLEGKFNESSVSILSELFKCSDNINISLFHNPLLGPILYNILPPRANEAIGVMHMKIYIGDNILMLSGANLSDSYLRNRQDRYFVIENKFLADSIHNIINTIQGMSFTLNRDLTIKWENDLMNPLIDAYVFREQYYRRIRFMLQGIQKHISQYNKNYSYNNYYKNIKNDPINDKTYIYNNQNNNKYSYTSNEFRMLNSFSTDIFDKDTYNNKNQKNNHKKENMETHTLLDTNHGTCDSTINLLNNNQNENHTNNLFTYLNEKDEFFYPLFEKNKSILVLELSLQCGFSIPPIYDETDMLENLLKNIEKYDQSLVISSGYLNFPMNFLKLIRNIYINVMQKKNGILQLITASPCANSFYKSKGISYYIPSSYSAMANVCIEYITKNLTNFLKKVNGQNVSEQNDISNQKIYIEYYKPSWTFHSKGIWIMDNMKSMKNVSNDNDNDNDNNNNDNNNNNNINNNEFHSAKKYEQNVNNSPNVKNNLNKSEYFNNENFDKNIDEENDYYDNLPWCTVIGSSNYGYRAKYRDLEMSFIIKTNDYNLRCQLKKELNIIYESSHFVQVDELKLRYAFWLKFLVKYIFKWLL
The following text describes a protein:
Function:
Regulation of intracellular pH homeostasis in response to cAMP, which is essential for chemotaxis. Necessary for F-actin localization and the kinetics of actin polymerization during chemotaxis and cell polarity but not for directional sensing.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Note=Predominantly localizes to the leading-edge of the chemotaxing polarized cells.
Sequence:
MKLNKSYILIVVLLLSLFYSSVSSTKTTLIKSNNHYNSDNSNNDNKNININNNNDGDGDDDDDNNKILITPENQNHLIHDIGIDSSSTEILFGSSSNSGSCGEKNNTKQNALANQREANTIIFIIMLILTGSVLIVYFIISLDIPFVPESVAVVTYGIILGIVFRFFYSDIVNHVVSFEPENFFLFILPTIIFETGYSLHKTDFFNNIGPILMFAVFGTIITFLVVGFGIYIVGYFGVSIALSLKDSFAFGSIISSTDPVCTLAIFQALNVDPMLYILVLGESILNDATSMMLYSVVEDTSTRDIIISCAMFTVVAIGSVILGVVMALLLSLILKWINIGKFPALETIFMVMFSYMSYVLAGALDISGVLAVFFFGITLNQYGAYSLSPYTKLTSGQLFRTAAFISETFLFLYFGLSLTAHEFKFDLGLFSWSILFTCLARAISVFPMCFLLNKFLKTKIPWVIQVAIWFAGLRGAFAFSLSLDYISEDEHMNAYIRTNTLLVVVFTIFVFGMGTYPLLRVLGIKTSQTDQSLDNISKPMSKQTKQKDRTKLYESFDDKYFKPWFRKRVPPLANEAIEIFEKMVIQSSHDHELDSNPLRFDDDEEDDDDEDLDFDSDLDLNININTDSIHQSDNNNNDNGNNNNNNNNIIINNNSQHHSNDGSNNKNNDTLPLI
The following text describes a protein:
Function:
Part of a complex with dlc-1 and egal-1, which is recruited to the nuclear envelope by unc-83, where in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells (Probable). Required for the formation of dendritic branches of PVD sensory neurons.
Subcellular Localization:
Nucleus envelope. Perikaryon. Cell projection, dendrite. Note=Probably recruited to the nuclear envelope by unc-83.
Sequence:
MAESELEKLRQDIAILTEKYEQAKEDIHKAANAGLELLRQKEDLEKRLAEMQAELDLARTEIDKTNQTLAEYRSQHQRSTRSELENEESLLEESSAKEEEYLQRIAKLEADLKKKEQELAEKKEELESIEKKHSKEIDSGAALEDERRKLRAELKETKEREQRLISEYSELEEENIGLQKTVANLRGSQVEYESLRIDNNRLEETIEIMKMAAEEDEILRVIADKQLEEALLTAQQERDQRLAMKRELEQTRNAEHISSLNDMLFGLERLGEDGELPPPQPGASDLFSELQGSSDVKVRELEAAKEGLQEELKSREKIFIEFVTGLADTLNIHRPTNELDYMHARQQKDVVLEKIQNIARDTDRHDKEGEEKRSGILKADLRTLVLVAGEKSAQLAAAQDAMIQVSDQLYQFYHQMTQNQGVQTEKSVQEIVKKLRLLARANAEDVPRVSLADEGVESGTETDVNASRSIPLNSDRLVIAPSFAKEIEKKLASVKIGDVLSETDLRQRILTEGNAISETTESLKKMIQVVKRTSEQAFNQAVMASGAENEIEMQNMKLRSLLSTKRDQISTLRTVLKSNKLTAESALTSMREKYESEKKMMMEINDKMRRELKQLKEDAATFASHRAMFTARGEELKSKVEELSNELRANEEEKKTLNQLLRLAIQQKLTLTQRLEEVEVDRDRQVFKRSSTRAPTRETYQPPRAVRYPGSTTTAQQPAPSSSGGSRGGPRRGDNQQ
The following text describes a protein:
Function:
Transcription factor involved in neuronal fate specification. First required in embryonic CNS development to define the number of cells that express apterous (ap) in the ap thoracic cluster of interneurons. Later on, it plays a central role in the combinatorial code of transcription factors that specifies the fate of the Tv neuron in the ap cluster by participating in the transcription regulation of FMRFa in Tv cells. Also required for projection neuron dendritic targeting.
Subcellular Localization:
Nucleus.
Sequence:
MAELPTAPNGVPSGDYLHRSIDQLRSLGHLTTAQLVHDYKPFNISEFRQNVAERLDYSLKNGLVQHQQQMVMEQQPHPDQQQQQHLHHPQQQQHPPQLKVSYSAPNSPPTPHEQQEQKYDPNRSPPRQQMSSASGSGSNGSSPEEESRRGDGDQAKPYKCGSCSKSFANSSYLSQHTRIHLGIKPYRCEICQRKFTQLSHLQQHIRTHTGDKPYKCRHAGCPKAFSQLSNLQSHSRCHQTDKPFKCNSCYKCFSDEMTLLEHIPKHKDSKHLKTHICNLCGKSYTQETYLQKHLQKHAEKAEKQQHRHTAQVAAHQQHVPASGIGLNLQRQAMNDVNAAYWAKMGADSAAASLAEAIQQQLPQAGGQPYGNFASLQQQHQQQQQELLHHQRLADTPGHSHSPHEEAAGEDLVLRQSTPQHHLQQQQQQQQQQQAQQQQQAQHQPSPGPGNSAFTPLSATVAPPPHLQQHRGPPGSAAAYLYQQNAAAAAAAFPTQLISLHQIRNYAHQPGAAGLIAGDHLALGLSAVNAAKEKAQ
The following text describes a protein:
Function:
Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections. Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS. Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines. Involved in memory-related synaptic plasticity in the hippocampus.
Subcellular Localization:
Cell junction. Cell projection, dendrite. Cell projection, growth cone. Cytoplasm, cell cortex.
Sequence:
MAGVSFSGHRLELLAAYEEVIREESAADWALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGRPYCPFIKASDSGPSSSSSSSSSPPRTPFPYITCHRTPNLSSSLPCSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEVHDAADAIETDTATADTTVANNVPPTATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGEPLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD
The following text describes a protein:
Function:
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
Subcellular Localization:
Cytoplasm.
Sequence:
MTRVEELLSQIKNLKTEKNAIILGHNYMEYSVQLVSDFTGDSYDLAVKAMKTNAKIILFAGVYFMAEQASALNPNKKVLSPDPNAGCTLSDSLDVKTLQEYKEKYPNAPVVLYINTSIYAKALADYIVTSSTAVKVVQKLNADTILFGPDANLANYVQQKVPNKKIIKVPPNGRCIVHANYTKQLVELARKKYPNALLMAHPEAPLEILESADFVGSTNQMIQFSKENKNEEFIVATEIGMINALKIKNPSKKFYPLVTTEACACARCPYMNMINLEKVKRSLEEEVYEVKVPEDIAERVKRAFENTMKLL
The following text describes a protein:
Function:
Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
Subcellular Localization:
Cytoplasm.
Sequence:
MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYDK
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
MNQEGGLWALLPSKVSSRDQVTGHKLALLVLVSEYCRVKTERHLKPDQELWTHTTKQCRDFAITALKLLQSPDMSLGELLSCLDGVLHPNTMRLFTVSLRTIYDAGVAGIMDYIPNLDNLLADPTATPAVLHKSSVLGLFVRRMLLALDKLNFSGLVKLHQSFRSYYDAEGNGDSKATQRQADLFLAQQVTLMQVNEKAALPPPQLQQKLRELVGGNPALTEAHYVSFLNCLSVKEYFGAVESLRQHFDRTSAPDASSKPGPMATAASSEDSGRNLRYASLHLAMLHAKMGHDAEARAALREAVTLAQDANDVVFLQHALAWHCRLDGARCPEAQLRCSVTRASELGLCGIASLGIQALTRVGAEAGSPPAAALELLSRSEVLNFQHPQGDTGIGTVTSQKAALWTLYGFQRMANLQAQLLLQLGRADQLRTAGVVPMGEPACLALRSLAWALTLHGRYNDSTSLLDLASTLFPAYSACQNLVTLCRLECSFHEALHKTLWPRAEGLASGIRILNRFEGDLCKVKLLLWQGHLNEALDLVDTVLAIEDIKGTGDGDNTSNFEGSLPHFKGRCYLLKAEILIESSQPVLAIPVLCEGLTLAEKHHLSYLRASLVVLMAGVQFE
The following text describes a protein:
Function:
In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (By similarity). Plays a role in the initiation and/or maintenance of suckling in neonatal mice. May also play a regulatory role in the immune system (By similarity).
Subcellular Localization:
Secreted.
Domain:
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
Sequence:
MPAGRPGPVAQSARRPPRPLSSLWSPLLLCVLGVPRGGSGAHTAVISPQDPTLLIGSSLQATCSIHGDTPGATAEGLYWTLNGRRLPSELSRLLNTSTLALALANLNGSRQQSGDNLVCHARDGSILAGSCLYVGLPPEKPFNISCWSRNMKDLTCRWTPGAHGETFLHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEATNRLGSARSDVLTLDVLDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAASTPRSERPGPGGGVCEPRGGEPSSGPVRRELKQFLGWLKKHAYCSNLSFRLYDQWRAWMQKSHKTRNQDEGILPSGRRGAARGPAG
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (By similarity). It activates the synthesis of GCN4 in yeast under amino acid starvation conditions by suppressing the inhibitory effects of multiple AUG codons present in the leader of GCN4 mRNA. It may promote either repression or activation of GCN4 expression depending on amino acid availability. GCD1 stabilizes the interaction between eIF2 and GCD6 and stimulates the catalytic activity in vitro.
Miscellaneous:
MISCELLANEOUS: Present with 9530 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSIQAFVFCGKGSNLAPFTQPDFPFQTQNKDSTAATSGDKLNELVNSALDSTVINEFMQHSTRLPKALLPIGNRPMIEYVLDWCDQADFKEISVVAPVDEIELIESGLTSFLSLRKQQFELIYKALSNSNHSHHLQDPKKINFIPSKANSTGESLQKELLPRINGDFVILPCDFVTDIPPQVLVDQFRNRDDNNLAMTIYYKNSLDSSIDKKQQQKQKQQQFFTVYSENEDSERQPILLDVYSQRDVTKTKYLQIRSHLLWNYPNLTVSTKLLNSFIYFCSFELCQLLKLGPQSMSRQASFKDPFTGNQQQQNPPTTDDDEDRNHDDDDDYKPSATSIQPTYFKKKNDLILDPINCNKSLSKVFRDLSRRSWQHSKPREPIGIFILPNETLFIRANNLNAYMDANRFVLKIKSQTMFTKNIQIQSAAIGADAIVDPKCQISAHSNVKMSVLGTQANIGSRCRVAGSLLFPGVHLGDEVILENCIIGPMAKIGSKCKLSNCYIEGHYVVEPKNNFKGETLANVYLDEDEEDELIYDDSVIAGESEIAEETDSDDRSDEDSDDSEYTDEYEYEDDGLFER
The following text describes a protein:
Function:
Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.
Sequence:
MATKVHVQHKDVHHNLSVDGFIQYTPCYCEENIYQLAKLFDGQGQVVFITTKTKTTPIWEQKVGKEPDGLVVWDYHVVFLSRGTDNNDWNVWDFDSKLPFPTTWSEYRYKALKRVQQTYEGNVLDPDSPCLERCFRVVSAKQYLDHFSSDRSHMRTETGDWLAPPPLYPPIGKGRSSNLETYLDMQTHIEDSVFGRVHDEDSIDSMLFTSC
The following text describes a protein:
Function:
Calcium-binding peroxygenase involved in the degradation of storage lipid in oil bodies.
Subcellular Localization:
Lipid droplet. Microsome membrane.
Domain:
Transmembrane regions are predicted by sequence analysis tools, but these regions probably constitute hydrophobic domains associated to phospholipids; The proline-knot motif may be involved in targeting to lipid bodies.
Sequence:
MASNESLQTTAAMAPVTIERRVNPNLDDELPKPFLPRALVAVDTEHPSGTPGHQHGDMSVLQQHVAFSNRNNDGIVYPWETFLGFRAVGFNIIISFFGCLIINIFLSYPTLPGWIPSPFFPIYIDRIHRAKHGSDSEVYDTEGRFVPAKFEEIFTKNAKTHPDKLSFSELWNLTEHNRNALDPLGWIAAKLEWFLLYSLAKDPHGFVPKEAARGVFDGSLFEFCEKSRKVKQATVKSLTFKI
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular Localization:
Cytoplasm.
Sequence:
MAKSKNHTTHNQSRKWHRNGIKKPRSQRYESLKGVDPKFLRNMRFAKKHNKKGLKKMQANNAKAMSARAEAIKALVKPKEVKPKIPKGVSRKLDRLAYIAHPKLGKRARARIAKGLRLCWPKAKANDQTKAQAAAPPSVPAQAPKGAQAPTKASE
The following text describes a protein:
Function:
Involved processing and trafficking glycosylated proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.
Sequence:
MGFDVAGYLQSYSLKDWIRIIVYVGGYMLIRPYLMKLGAKIQEREHRKSLLEGEVDGTLDPEMTHGTKPKEHGEFDTDDEEEEENPDAEFRWGYSARRRIRKQREEYFKNQDKSPLDAYADDDEDIEEHLED
The following text describes a protein:
Function:
Snake venom zinc metalloproteinase that inhibits ristocin-induced platelet aggregation by abolishing the binding of von Willebrand factor (vWF) to platelet glycoprotein Ib alpha (GPIBA) through the cleavage of both GP1BA and vWF. Also has fibrinogenolytic activities by degrading the alpha- (FGA) and beta-chain (FGB) of fibrinogen. In vivo, induces a slight hemorrhage when applied to chick chorioallantoic membrane and has potent antithrombic effect.
Miscellaneous:
MISCELLANEOUS: Negative results: does not induce thrombocytopenia after injection into mice.
Subcellular Localization:
Secreted.
Sequence:
LLRRKSHDHAQNHDGDKCLRGASLGYYQSFLNQYKPQCILNKP
The following text describes a protein:
Function:
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Cytoplasm.
Sequence:
MLKTLPPTLREKKRYVALEIIYEMELSQKDVISVVRNALLNYSGVLGCSRTNPWLIDYGHPYGILRISREEVDTLRSSLSLMGEHKKKPINIRIIGISNSVKHIREKFLHVPHEPYYKVIQKLKRKGPKK
The following text describes a protein:
Function:
Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.
Subcellular Localization:
Cell projection, dendritic spine. Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MDEQAGPGVFFSNNNNNNALLLPPPPASSSQAGAEPGEAAAAAAAAAAVAAAGGVAGPPSSSSSSPSSGAAVPASAARAQYSVPGILHFLQHEWGRFEAERAEWEAERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPNYDSDEGNETEVQSQPNSQLIWKQGRQLLRQYLQEVGYTDTILDVKSKRVRTLLGLSGDDPDRDNDKNQESMVNGADAEIKEKVMIGKPDLTDSASLLETFKFLENAAAEFSDEDDDDDVDGRERTIMDTSTIVRRKVVSDNNDDRDTEEALKEFDFLATSDEGDGESRSSGDGTDWEKEDQCLMPEAWNVDQGVISKLKEQYKKERKGKKGVKRKTTEDMFQPQSYIKQSKQGCGKMMEQNTGPNRSKLQDMLANLRDVDDLPALQPSVVPPTRPSTSRLIEQEVNRTDEVEALTFPPSSGKSFIMGTDEALENELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRGLAFHPVEPVLITASEDHTLKMWNLQKTSPAKKSASLDVEPIYTFRAHTSPVLCVVMSNSGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGAFIGHTDAVWGLVYSGTHQRLLSCSADGTIRLWKALEISPALNIFNDNQEMGIPSSVDLVSSDPNHMVASFNSGHTCIFNMETRQRILTLESDVDTVVTSSCQINKVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLDAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKHDESIHDVAFHPTKCYIASAGADALAKVFV
The following text describes a protein:
Function:
May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPNQQKKVVFCTAGVLSFVCALGVVTALGTPLWIKATFLCKTGALLVNASGQELHKFMGEMQYGLFHGEGIRQCGLGARPFRFSLFPDLLKVIPVSIHVNVILFSTILVVLTMVGTAFFMYNAFGKPFETLHGPLGLYLLSFISGSCGCLVMILFASEVKIHHLSEKIANYKEGTYAYKTQSEKYTTSFWVVFICFLVHLLNGLLIRLAGFQFPFAKSKDTETTNVAADLMY