lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
Domain:
Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.
Sequence:
MSRPTYLQALAERVLIFDGAMGTSIDTFDLTAADYGGEATFGCRDYLVITRPDVIEAIHTSFLEAGCDVLETCTFQSTRPRLAEWGLGERTVEINRAAAALARRVADRFAARDGRPRYVAGSMGPTGKLPSSDDPALSDITFAELSDIYYEQAIGLIEGGVDLLLVETSVDILEVKAALDGIRRAKIDLQRPDIAVQAQVFLDLSGRMLLGTDVPAMIATLEAMPVDVIGLNCSTGPEHMRAAIQYLTTHSRKPISCIPNAGLPLEVDGRTVYPMEPEPFAAILGEFVREYGVAVVGGCCGTRPAHIARLRQILGDAPRPKQRQVEYIPSVSSGIRAAALRQDATLTMIGERLNTLGSRKVKRLLLRDDYDGALEVAREQVESGAHMLDVCVAMTERNDEKEQMTRLIKKLTLNIELPLVIDTTEADVLEAALSIYPGRALINSVSLEGGRGAKIDKVLPLAARYGAAVIAMTIDEEGMAHTAERKVAIAERIARIAQEEYGIPAEALVFDVLTFPITTGQEELRYSAIETLEGIRLVKQRIPGCFTTLGVSNLSFGVAPHARAALNSVFLYHAVAAGLDTAIINPAHVTPYAEIDPAQREVCEDLIFARREDALARFIAYFEQHAASQDNEREDPTAAMTVDQRLHWKILHRKKEGIEDDIDQAVDQRLQASGLRLSDPAAALRNEHGTSPQGQAAVDVLNTVLLPAMKEVGDLFGAGQLILPFVLQSAEAMKKAVARLERYLDRIEGASKGKVVLATVYGDVHDIGKNLVYTILSNNGYTVYDLGKQVPINTIIEKALEVQADAIGLSALLVSTSKQMPLCVQELYRRGIHIPVLVGGAAINRQYGQRITFVDDEEPYPAGVFYCKDAFEGLETMDRLSDPATREQFIEQTIREAANVLHRRVTGRVALTELGEAAKASADGVRSAVRTDVPVPVPPFWGWRATSRIRLSDVVECLDRNSLYRLQWGAKNAKGAEWERLRTEFDQKVRELIAEAERDGWLQPRVIYGYFPVQSDGLELIVYDPADRRRELTRFVFPRQPARERLCISDYFRSVESGEYDLAAFQIVTMGSAVDELVETLQQRGDYSRSYYIHGLGVSLAEALAEYTNRIIRQGLGLDERRGKRYSWGYPACPDLAEHAKLWQILPGEEIGVTLTEAFQLVPEQSTAAIVVHHPEAKYFSIGSALERAEMDQRGDD
The following text describes a protein:
Function:
Binds to the 23S rRNA.
Sequence:
MGAGTAPKGKRNRTPTHIRCRRCGRRAFNVKKGYCAACGFGRSRRMRKYSWSHKWRKKRNLSY
The following text describes a protein:
Function:
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MKDTVSQPAGGRGATAPRPADAASPSCGSSPSADSVSVVLAGGGTAGHVEPAMAVADALVALDPRVRITALGTLRGLETRLVPQRGYHLELITAVPMPRKPGGDLARLPSRVWRAVREARDVLDDVDADVVVGFGGYVALPAYLAARGLPLPPRRRRRIPVVIHEANARAGLANRVGAHTADRVLSAVPDSGLRRAEVVGVPVRASIAALDRAVLRAEARAHFGFPDDARVLLVFGGSQGAVSLNRAVSGAAADLAAAGVCVLHAHGPQNVLELRRRAQGDPPYVAVPYLDRMELAYAAADLVICRAGAMTVAEVSAVGLPAIYVPLPIGNGEQRLNALPVVNAGGGMVVADAALTPELVARQVAGLLTDPARLAAMTAAAARVGHRDAAGQVARAALAVATGAGARTTT
The following text describes a protein:
Function:
Dioxygenase that catalyzes the alpha-oxidation of 2-hydroxy fatty acids in an iron-dependent manner. Involved in metabolism of phytosphingosine and is required for proper endoplasmic reticulum stress response.
Miscellaneous:
MISCELLANEOUS: Present with 486 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGEGLLDLRSQLGFYKFYHHNPKNVLIHSIFVPTILFSGSCMLHRVKIYQSISLTAVLSVLFSIFYCLLYLPTGLLAGVLLLLLNLALIDHRVDLTFKQELGLFTIGWIFQFVGHGVFEKRRPALIDNLVQSLVLAPYFIMFEFLFKLGFMPRLKATLEHDLEIKQRNLRMQRQ
The following text describes a protein:
Function:
One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. This subunit is found at the monomer-monomer interface.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Sequence:
MEVNILAFIATALFILVPTAFLLIIYVKTVSQND
The following text describes a protein:
Function:
Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development (By similarity). Also plays a role in induced pluripotent stem cells (iPSCs) reprogramming.
Miscellaneous:
MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Nucleus.
Sequence:
MAEDGSEEIMFIWCEDCSQYHDSECPELGPVVMVKDSFVLSRARSSLPPNLEIRRLEDGAEGVFAITQLVKRTQFGPFESRRVAKWEKESAFPLKVFQKDGHPVCFDTSNEDDCNWMMLVRPAAEAEHQNLTAYQHGSDVYFTTSRDIPPGTELRVWYAAFYAKKMDKPMLKQAGSGVHAAGTPENSAPVESEPSQWACKVCSATFLELQLLNEHLLGHLEQAKSLPPGSQSEAAAPEKEQDTPRGEPPAVPESENVATKEQKKKPRRGRKPKVSKAEQPLVIVEDKEPTEQVAEIITEVPPDEPVSATPDERIMELVLGKLATTTTDTSSVPKFTHHQNNTITLKRSLILSSRHGIRRKLIKQLGEHKRVYQCNICSKIFQNSSNLSRHVRSHGDKLFKCEECAKLFSRKESLKQHVSYKHSRNEVDGEYRYRCGTCEKTFRIESALEFHNCRTDDKTFQCEMCFRFFSTNSNLSKHKKKHGDKKFACEVCSKMFYRKDVMLDHQRRHLEGVRRVKREDLEAGGENLVRYKKEPSGCPVCGKVFSCRSNMNKHLLTHGDKKYTCEICGRKFFRVDVLRDHIHVHFKDIALMDDHQREEFIGKIGISSEENDDNSDESADSEPHKYSCKRCQLTFGRGKEYLKHIMEVHKEKGYGCSICNRRFALKATYHAHMVIHRENLPDPNVQKYIHPCEICGRIFNSIGNLERHKLIHTGVKSHACEQCGKSFARKDMLKEHMRVHDNVREYLCAECGKGMKTKHALRHHMKLHKGIKEYECKECHRRFAQKVNMLKHCKRHTGIKDFMCELCGKTFSERNTMETHKLIHTVGKQWTCSVCDKKYVTEYMLQKHVQLTHDKVEAQSCQLCGTKVSTRASMSRHMRRKHPEVLAVRIDDLDHLPETTTIDASSIGIVQPELTLEQEDLAEGKHGKAAKRSHKRKQKPEEEAGAPVPEDATFSEYSEKETEFTGSVGDETNSAVQSIQQVVVTLGDPNVTTPSSSVGLTNITVTPITTAAATQFTNLQPVAVGHLTTPERQLQLDNSILTVTFDTVSGSAMLHNRQNDVQIHPQPEASNPQSVAHFINLTTLVNSITPLGSQLSDQHPLTWRAVPQTDVLPPSQPQAPPQQAAQPQVQAEQQQQQMYSY
The following text describes a protein:
Function:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSWQSYVDDHLMCDVEGNHLTSAAILGQDGSVWAQSTNFPQLKPAEIEGIKKDFEEPGHLAPTGLFLGGEKYMVVQGEAGAVIRGKKGPGGVTIKKTNQAFVFGIYDEPMTGGQCNLVVERLGDYLIESDL
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase.
Subcellular Localization:
Nucleus.
Sequence:
MDVATARRRLRAFKRWMSKHGVVCSDALCLDASEAGGVYVRALSALREGDLVATIPRRACLTPRTSGAAAAIEAAELGGTLALAVAVMYERARGAESPWNAYLRLIPDCEPVPLVWPDEEAERLLSGTELDKIVKQDREFLCEDWKECIEPLISSGDLGVNPEDFSLEKYFAAKSLLSSRSFHIDSYHGSGMVPLADLFNHKTDGEHVHFTKVSDASDSDEGEDDDDQSNAGSDEEQNDEGTDDRSNTDSDEEENDDDQSNADSDEDLDRDENNASADEQSTVENSATNPSGYNDEDLEMIIVRDANAGEEVYNTYGTMGNAALLHRYGFTELDNPYDIVNIDLTLVTKWCSSKYSRRYARARVSLWRNLGYSGCTSQDSEYFEISFDGEPQLELLILLYIISLKPDAYDKLASVAHDLIGDDELDDEQSIISSFVKVVRVTSPTKKSKLKGGEKIPFVKKLLHSESICSALASLADMRERLYGSNTLKSEKEKLQMCSPVSQRNLYHSLVLRVSERKILRRLRKLASSWSKTKKRKRI
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MVAKPKRRLASGEVDLNTSPSSKLASPREQRKQPKRRTLHSQLHSSSPPSPQALIDDPEEQEEEHHQQEPQPNSSSPSHNQSISDQRPSLTTHQQAQEENDKDQEEEHQKTIKEQEARERIFDEFKDEYFDIIDQIPLDLNRKFSCITELEASLEECKRELHEDLIAYTNFAKEMASAAGPESTIAGTAVEVDNEITNRLRTLAQPMLWGVVPIPPINADTTSGLPEHLKSLLSEISGKIIRLQELSHDKLNLAESVYVSLDRQLKRLDADLETYQDLEDQDAQVERRHHEALNDQSDGHDQSNQPSQQEQPQLTPTSTRLNQQPHVGEQAQELTLEPSGSFNSADDQTLYCSCQRVTFGDMVACDNPDCQGGQWFHLECVGLSQLPTEDNQAEWFCDQCRSQSSTASASHSGKKKKKKIGRRY
The following text describes a protein:
Function:
May be involved in cell wall biosynthesis.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MAVSSLAVLETSCSIRRSLNASDESPSRQYGKVSISPSSALLPERALHRSKTGTVHDSAVPCIKSSVGLVFLSLVSLVVVSVPFLNDRSGMSLSCPFAPPSEGRDRERGSSAPAGESKISIEVKTPSDGRKQSADYEEREEFAEDNCWSRSRHLLYRPDDRRLPSSPALERSLLEYEALQARCTSGKTWESMADLQPENSQDDCKYVIYMEGWEGLGNRLLSLVSAFAFSLSTDRVLLIDTRGHLASLLCEPFDSSSWKLPGSFPYAEAQAFHALGDVENYQNEVGINLNLRHQQSRRDQAFFCPETQERLKNVKWLAWNSNQYYVPRLLMVPALWMKLNPLFTNPSHLFSQLVRFLCLPANPIWAKTERTYQSYLLSSRKLVGLQVRAQLQHDFSPEVYDKVRSCLLGGGIVPNVSRHNSAPRHFFLRGKKSTGSERGTSIFVASLQREYYEALRDLYTDRGTEDGSLVSVHMMAYEGAERFTYDQAVKAYIDIWLLSFSDTLVTSGWSTFGYVAQGLAGVQPYMMNLREDAAPPFCYFGHSIEPCNHYPFLSKCGTTRKLSKEHESWVNAHLRPCQDESQGLQIV
The following text describes a protein:
Function:
Part of a membrane-bound tetrathionate reductase that catalyzes the reduction of tetrathionate to thiosulfate. TtrC probably anchors TtrA and TtrB to the periplasmic face of the cytoplasmic membrane. May transfer electrons from membrane quinol to TtrB. During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S.typhimurium over the competing microbiota in the lumen of the inflamed gut.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTHSLIIEEVLAHPQDISWLPWAVQYFFFIGIAACAALFACYLHWRKKDAATEENRALLIAITCAITAPLALTADLHQTARVWHFYAWPTPWSWMPWGALFLPLFTGFLALWFLAQQIKRLFNKSYNVTKWLALASALCAVGLLIYTGREVSVVLARPIWFSYAFPVAMFLSALQAFFALMIVAARRDSVRLPKILWGQIWTLAALGLVVAMWVSGDTLSGTAIRQWITVALSAKYYAVGWVALWVCTLLFCSLALRHPLSQLRRVLLVLSALALCWLMRWTLLIQVQTVPKFNAQFNPYSLPGGTDGWLAILGTFGLWIALLIIIRETLNGLTRRLQHG
The following text describes a protein:
Function:
Ethylene-responsive N-acetyltransferase required for differential cell elongation in the hypocotyl. Regulates apical hook formation of dark-grown seedlings. May control differential cell growth by regulating auxin activity. May be involved in negative feedback regulation of auxin homeostasis through the control of GH3-like genes. Modulates de novo shoot organogenesis.
Sequence:
MTVVREYDPTRDLVGVEDVERRCEVGPSGKLSLFTDLLGDPICRIRHSPSYLMLVAEMGTEKKEIVGMIRGCIKTVTCGQKLDLNHKSQNDVVKPLYTKLAYVLGLRVSPFHRRQGIGFKLVKMMEEWFRQNGAEYSYIATENDNQASVNLFTGKCGYSEFRTPSILVNPVYAHRVNVSRRVTVIKLEPVDAETLYRIRFSTTEFFPRDIDSVLNNKLSLGTFVAVPRGSCYGSGSGSWPGSAKFLEYPPESWAVLSVWNCKDSFLLEVRGASRLRRVVAKTTRVVDKTLPFLKLPSIPSVFEPFGLHFMYGIGGEGPRAVKMVKSLCAHAHNLAKAGGCGVVAAEVAGEDPLRRGIPHWKVLSCDEDLWCIKRLGDDYSDGVVGDWTKSPPGVSIFVDPREF
The following text describes a protein:
Function:
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C seems to be required for multiple steps in cardiac formation. Involved in heart development and required for differentiation of the atrioventricular boundary. Required for neural crest cell development.
Subcellular Localization:
Nucleus.
Sequence:
MADMDELFGSDGDSDNEQRDSGSGSGSDSDHERPRSASNASGSESAQSDRDHDDDEDEDGGKPSNKELFGDDSEDEHGSQHSGSQHSGSRHSGSRHSGSRHSGSRHSGSQHSGSQSERSGNQSDATMHSDNEHSMSEAHRGEQDDEDDDDRGHRSDVGSPASGAGSRRSDRGSGSPGSEAGSPRSEAGSGHSDPGTPHTDGEGSGKDAHSGDEKWGGDGKSDQSEDEDKQQNSDDERERSDEEGERQKSESIKGSDSEDDFTRKKKKKIASDSDSDSDAETQGGKKPAANDLFGEADDISSDSDAEKPLTPGQPLDADDGMEGDQPEEEPAPETRIEVEIPKVSTDLGSDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRSRRDEEGNEVKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPESQRNEMIKKEEERLRASIRRESQQRRMREKQHQRGLNAGYLEPDRYDEDEEGEESISLAAIKSKYKGGGGLREERARIYSSDSDEGSDEDKAQRLMKAKRLDSDEEGENSGKRKAEEDEESASKKPKKYVISDEEDEDGDGERDGDRERGGDMDGDGDGDMEGDGDVDRDGDMDGDGEGDGEGDGEEDE
The following text describes a protein:
Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
Subcellular Localization:
Cytoplasm. Endosome.
Sequence:
MAEYLETTTSLLPKLKSEERIELAQPNVGLYLNGHKSIDHMEGTLYLTNRRICYVDDTQPTVHSLSINLTDVSDLQITNRFLRSSAKISAKVNSTRRYLICRICSFTNHSYPHIPCKQCGVAGRYKEIAASTDVNNLESGRCSVCTFQNHPMILDCEMCGTPLRQSKSLDIKFSFHIGGAHTFWGALNQKCQEASSTDSDLKQKRILKQTIREKAITLGGVHALQVSHQKQVKQSGATLTRAFQDLNAFMSLAKQTNDLIKNLSQQSKETNLSPTNNDLEMTVTRSYFDQFSSYDVSLTTTTELSKSVAQVLHSYFKKTSCAAVTLTVAWAIYNRTRGIDLINPSLFLSVCQEMVKMNLGIRQITFPSGLIVLELVDDHRSNVLELIMSTMKPYTSALECAVTLGWPVNVALEHLHQAEIEGSIVRDMDEVKGTGIKYWKNMFLDTEFQENP
The following text describes a protein:
Function:
Involved in the TonB-dependent uptake of iron in complex with schizokinen, a dihydroxamate-type siderophore.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MDCVTSHNPVATFRCEVKMKPGKILFLLLLTGSVWSLISHPGKTQEAPSPTQLNTQSPAPNAQELTQVTGVRVVPTVQGLEVILDSTAAEKLQVSTQNQGNSLIADITNAQLNLSEGNTFSQNNPATGVTNVTVVNHNDNTIRVTVTGEKSLPKFELFDSDTGLILAFTATEVAQDSPAEVDEPIELVVTATRTETPIQNVPRSITVIDREQIAAQASTSRNLIEILGKTVPGLAPPAQGASNFGLTLRGRNPQVLIDGVPQSTTRNASRDLRTIDAAAIERIEVVRGPSAIYGDGATGGVINIITRRPTEEKLTSRTEVGVSAALGNLEGDSFSTNLQHFISAKQGNFDFTFNFAVAKNGGFFDAQGDRIPSDPNAQGGFADASSINLFGKFGIDIDANQRLQLTFNRFDEKQDTDIASDPRVNTIPGRQKARALEGLSLDERPGNENTFINLQYTHDDLFNSKLQAQLYYRDYLTRFFPFDGRSFASLGNEIFQSRVESEKYGGRLQIETPLFNQGAAKLLWGVDYSQEDTSQPVSVFDQAAFVASGGLAFRKTGDRSWTPPLELRSLGLFAQLNWEISDRFVFNGGVRYENADVSVNDFRTLANPNVTIGGGDLNFNATLFNVGAVYALNPQLSVFANYAQGFSLSDIGLALRNAPPGFSVESLNPEPQKVDNYEIGIRGQWDTVQASLSAFYNESDLGTTFTAPGTVIRAPERIYGLEAAIDAQPSSTWQVGGTFTLIGGEIDSNNDGDYESLDGFRIPPLKLTAYVENETLPGWRNRLQALYSGNREVFGNNNTAFGRRPVESYLTVDYISSIKLGAGTLQLGLENLFNSQYFPVVSQLQANDSAYAAARGRTLSIKYSFDW
The following text describes a protein:
Function:
E3 ubiquitin-ligase probably involved in organ size regulation.
Sequence:
MPMENDNGPHVGNVVVTAEQATKINETDGRLPENRQTGVVSDTGSGSERGEQGVGESAVAVAVPVEESGSISVGELPAPRSSSARVPFTNLSQIDADLALARTLQEQERAYMMLTMNSEISDYGSWETGSYVYDEDEFDDPENEDEDDDEDEYETDDDPQEDGLDVNVHANEDDQEDDGNSDIEEVAYTDDEAYARALQEAEERDMAARLSALSGLANRVVEDLEDESHTSQDAWDEMDPDELSYEELLALGDIVGTESRGLSADTIASLPSKRYKEGDNQNGTNESCVICRLDYEDDEDLILLPCKHSYHSECINNWLKINKVCPVCSAEVSTSTSGQS
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 1200 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MVFYKVTLSRSLIGVPHTTKSIVKSLGLGKRGSIVYKKVNPAIAGSLAKVKELVKVEVTEHELTPSQQRELRKSNPGFIVEKRTID
The following text describes a protein:
Function:
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Required for checkpoint mediated cell cycle arrest in response to DNA damage in germline cells. Essential for embryogenesis (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSADVSTKPRGSLPIPTAPGESNECYRVIRTLGEGAFGEVLLIVNNKNPDMAVAMKKMQITTQANTNNIRKEFLIQQKLSKVGHDNFIRAIGMRTENGFHFLFLEYADGGELFDKIEPDHGMPTAIAQFYFRQLIEGLKYIHDCDIVHRDIKPENLLLTTSHVLKISDFGMATLYRNEGKERLLDLSCGTIPYAAPEVCAGGKYRGPPIDVWSSGIVLIAMLTGELPWDRASDSSYAYLQWLGNNNLDENPWRKMDVRALCMLRRILTDNVHRRATIEQIKTDPWFTHNYGKLEMTYGRPLKRARYADENSPDCNISSTQQADAVSTAKRRHLETPDKVAHVERQNASFSQPTRTEDLLLTQNIDMSQNNTNLLERMVCRMTRFCTKFDVPTSYRQLIHASEHAGYEVRQTADNRLLVTFREVSMMVTLYSLKTESRVMVDFRRSRGDGIQFKKMFLEVRNRMNDSICVDGQNFLEDCGYVPRKPQFVREANA
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is required for normal cell wall integrity; it is recruited by RNA polymerase to transcribe genes with cell wall-related functions. It is also involved in the transcription of the dagA gene coding for an extracellular agar-degrading enzyme.
Subcellular Localization:
Cytoplasm.
Sequence:
MGEVLEFEEYVRTRQDALLRSARRLVPDPVDAQDLLQTALARTYGRWETIEDKRLADAYLRRVMINTRTEWWRARKLEEVPTEQLPESPMDDATEQHADRALLMDVLKVLAPKQRSVVVLRHWEQMSTEETAAALGMSAGTVKSTLHRALARLREELVARDLDARALEREERERCAA
The following text describes a protein:
Function:
May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Translocates to the nucleus upon heat shock, requiring S100A6.
Domain:
The CS domain mediates interaction with HSP90.
Sequence:
MAAAAAGPVAAASRLFRSFSDALIEQDPQAALEELTKALEQKPDDAPYYCQRAYCHILLGNYSDAVADAKKSLELNPNSSTALLRKGICEYHEKNYAAALETFTEGQKLNSADADLTAWIKRCQEAQNGSQPEVSASQRTHQSKIKYDWYQTESQVIITLMIKNVQKNDVNVEFSEKELSALVKLPSGDDYSLKLRLLHPIIPEQSTFKVLSTKIEIKMKKPEAVRWEKLEGQGDVPNPKPFIADVKNLYPSSSHYTRNWDKLVGEIKEEEKNEKLEGDAALNKLFQQIYSDGSDEVKRAMNKSFMESGGTVLSTNWSDVGKRKVEINPPDDMEWKKY
The following text describes a protein:
Function:
Prevents DNA hypermethylation and transcriptional silencing of transgenes and of some endogenous genes. May act as a molecular chaperone of IDM1, regulating its H3K18 acetylation activity.
Subcellular Localization:
Nucleus, nucleoplasm. Note=Colocalizes with IDM1 within nucleoplasmic and nucleolar foci.
Sequence:
MSDTMPEIVSPLVAENSQEQEESVLISLDIEEDKLFLLHFIIGTYFGPDLRKQHHRPKQSAFQIQALKNVVVDELSGSLMKRAELERVYYHIIRNVDPSLVMKPKKLREYFNAKRNDSNRDYPLFVDLFPRKLHPETHVRHKFKFIRSIVFINDPDTSCMREECVARFKRLTGLDSFALSLSVDVTKSNGVVAANEVKVEIDESVEPVKEDNAGTCTSGEESDVAAKPEVKSEAHGGLMVGLMDIGECDDAYLFRVSLPGVKRDERYFSCEVEDNGKVLVRGVTTTGGKRVKRYSHVFEMQTRSLCPPGNFSVSFRLPGPVHPHEFSGNFGTDGILEGVVMKNLQKQTV
The following text describes a protein:
Function:
Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
DSPGGASDAQKQHDVNSILXKVYXEI
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MSSYVANSFYKQTQNVPAYSMQSYGNYGSVSEVPSSRYCYSGLDLSITFPSPGSSNSLSALDMPSNPTANSERPSCTLMGSSGHTVGRGEQSVLNSGIYNQKTATTALEDRSKGIEGIKTEPAQSTPQGGQSQQQQQQQQQPPQIYPWMTKLHMSHETDGKRSRTSYTRYQTLELEKEFHYNRYLTRRRRIEIANNLCLNERQIKIWFQNRRMKWKKDTKVKSKDSL
The following text describes a protein:
Function:
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
Sequence:
MIDCRYYQQNECRSCQWLEIPCSQQLTEKQYHLKQQLISINYDEAQWVAPFQSNQQGFRNKAKMVVSGSVERPILGILKNPNDPQSAIDLCDCPLYPTHFSAIFSILKDFIGRAGLVPYNIAKQKGELKYILLTESIATEKLMLRFVLRTENKLPLIRRELPKLLEKLPHLEVISINLQPQHAAILEGEQEIFLTEQQFLPENFNGIPLFIRPRGFFQTNPKVAAGLYATAQQWVAEFPIYNLWDLFCGVGGFGLHCAKALQEKWGKPIKLTGIEISSSAILAASHSAKILGLEHVNFQSLDAASVIENKNENKPDLVIVNPPRRGIGKELSEFLNQIQPHFILYSSCNAMTMGKDLQHLTCYKPLKIQLFDMFPQTSHYEVLVLLERKKIN
The following text describes a protein:
Function:
Binds to the 23S rRNA.
Sequence:
MKVILKEDFINLGKEGDTVEVRDGFARNYLLPKGFAVFSNKHNIEIFNQKRRSILKKQEAKKQMANDLKSKLDLVKLEFFMKSNDSGKLFHSINSLNIADELLKLGFDIERKKIDIHHGTLKTFGTYDVTIKLYEGISSIIKVEIKKEKKQEDKKSLSKKLNKADEQGERAEV
The following text describes a protein:
Function:
Functions as a downstream effector of Rho-related GTP binding proteins of the 'Rho of Plants' (ROPs) family. Participates in the propagation of ROP GTPase signals in specific cellular responses. Required for actin cortical microfilament assembly. Activated by ARAC4/ROP2 to promote the assembly of cortical actin microfilaments required for lobe formation and lateral expansion of pavement cells. Interaction with, and activation by ARAC4/ROP2 is inhibited by RIC1. Functions as a downstream effector of ARAC11/ROP1 to promote the assembly of apical F-actin associated with vesicle accumulation in the tip of the growing pollen tube. Counteracts the ARAC11/ROP1-RIC3 pathway, which activates calcium signaling that leads to apical F-actin disassembly associated with exocytosis, to control actin dynamics and pollen tube apical growth. Downstream of ARAC11/ROP1, is involved in the growth responses to the root-colonizing endophytic fungus P.indica.
Miscellaneous:
MISCELLANEOUS: Over-expression of RIC4 in tobacco germinating pollen induces depolarized pollen tube growth.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MRDRMERLVVLPFSIGCISVSSVAVLSPLSKPHHHHSRQVIREQEEEDNMKNVFKFLAVSKPEISIGINRIFKSFKTISQLFADKDEEKEEVETSGMEIGVPTNVKHVSHIGWESGLTAATGPGKGWEDLIPPELLAAAASKKEINPHLHPTL
The following text describes a protein:
Function:
May participate in a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MATENVSRLQDFVAHSDKVNCIAIGRNAGRYLATGGEDRKVNIWHIGKPNAVATLAGHTSPVECVRFDNTDEVVVAGSSSGTLKLWDVKQGKAVRTLTGHKSNIRCLDFHPYGDFIASGSQDTNLKIWDIRRKGCIQTYKGHTEAINVLSFSPDGHWVVSGGEDGVVKLWDLTAGKLMTEFRDHAGPVTDLQFHPSEFLLATGSADRTVKFWDLESFQCVSTSRPESSRVRRICFDPLGRALYSGSKDSFKVYGWEPEVTYDSLSMGWGRLQDMHVKDPEGTTLVAASCHNESVSVWLVDLQNINFDRNNAKPAETQVVNRNSTMTSDADSAQRPRALPRAPAATANAARPRISSSSSTTASSGAAQLNVPAPKTEPNGTQALKRSWNKTDRPVIPSTRDKPLDLDVSEFLPSPIQDVKRNASQTEDELLASLRSGHTSMMTIMSTRARNIQIVKKIWAQGRHRNLMLANPNVWTLDCAVAVLPAFANLINSKHETYVIAACQTTNFLLKSFGTMIHAAGMTAAAGRSVDVSKEERHEKCCACYESLQVVKEALQARSDESGKLGSAIRKAMRAIEVM
The following text describes a protein:
Function:
Dephosphorylates MAP kinase mpk-1.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Note=Localizes in rod-like structures at the plasma membrane of pachytene germline cells.
Domain:
The KIM (kinase interacting motif) region may be involved in the binding to MAP kinases.
Sequence:
MTTHLPSTSQNGEEISAEQFNRIFHERNVIVLDCRSNGDSVKRANRFFCSLRLPALLQRRLMGGSMRLSTVPDLKDLNNSPDQCPEVLLIPGDSEQDEQLSAALARNLKSNHYRHFVLGEPVKTLLSQFPTLRDAADENWNTTFQMNSMPGQASGQQASSGPLLNLNQLRLEGEDQGGKQRAEFPVKLTNFLYLGNAETAKNRDVLKKYSISHVINVTSNLPNTFEEDPNMRYLRISADDNASHNLTKFFPEAISFIDDARRNDSACLVHCLAGISRSVTICLAYLMKTEMCTLDSAYEWVQKRNASIAPNFHFMGQLTDYEKMLGLNSNRVGTYPSSAPRSPSCAIEAAAVSQVGGLLTPPPTSCSASPQSSNHSAKSFH
The following text describes a protein:
Function:
Transcription factor. Probably binds to DNA sequences containing the consensus motif 5'-CGGA[AT][AG]-3'. Positively modulates expression of dopamine pathway genes, acting as a terminal selector for differentiation of dopaminergic neurons; may act in concert with homeobox proteins ceh-40, ceh-43 and ceh-20. Required for axon navigation in some interneurons, perhaps acting in the same pathways as basement membrane protein nid-1 and unc-6/netrin. Plays a role in the differentiation of the ventral cord pioneer neuron AVG. Required for morphogenesis of the pharynx.
Subcellular Localization:
Nucleus. Cell projection, neuron projection. Note=Initially localized only in the nucleus, but later in development, at about the 3-fold stage, expressed elsewhere in the cell body and also in the neuronal projections.
Sequence:
MQVVSSATLPPTVASADLAIVGGRSSDEDVIKYSAIQTIKQEQQQQQQQQSNTALPSYNFPFFNGMQNDFPPNRMLYNDNTMQKSENDHFTGMNLSTSASSSGNSTSSKDQSRRQFYTESSNSSGNGAAATSGSNGSSSSTESKSDVFNISMNAFAATPGSKSEDHNIPSFNMLSSYYTGALKLSNSTSFANPDPYQILGPTSKNLAHSGSGQTQLWQFLLELLSDKRYSEVITWEGTQGEFKLVDPDEVARKWGERKSKPNMNYDKMSRALRYYYDKNIMAKVHGKRYAYKFDFQGIAQALQPPTASHPQDYFNSHAMGRIAPDFSSWTSANYRSLNIAGFNNGSTIFNPSVNYSAFGATGTSNNLSAARAFPLYR