The following text describes a protein:
Function:
Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (By similarity). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (By similarity).
Subcellular Localization:
Mitochondrion outer membrane. Lipid droplet. Endoplasmic reticulum membrane. Lysosome membrane. Late endosome membrane. Note=May localize to endoplasmic reticulum-endolysosome contact sites.
Domain:
The FFAT motif is required for localization to the endoplasmic reticulum.
Sequence:
MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAEKEEKSLQDIKQKELCRIEEALQKAAEKGAHSGEFMYGLENLLYKDVKPGRKRKKHKKHFKKRFKGLDRSKDKPKEAKKDTFLEKLATQVIKNVQVKITDIHIKYEDDITDPERPLSFGVTLREFSLLTTNEHWTPCILNEAEKIIYKLVKLDSLSAYWNVGCCMSYRGSREHILEQLKREILTSTNIPPDHQYIFQPISASAKLYMNPGAESELKTPKLDGNVEVQNIAIELTKPQYLSMIDFLESLDYMVRNAPYRKYKPCLPLHTNCRQWWKYAIDSVLEVHIRRYTQPWSWSNIKNHRQLLKSYKMAYKTKLTQAKVSEEIQKQIQDLEKSLDVFNIILVRQQAQVEVIHSGQKLRKKSAEAGEKRGWFSGFWGKKESKKRDEESSVPETIDDLMTPEEKDKLFTAIGYSENAYNLALPKQYVAHILTLKLVSTSIIIRENRNVPEILRVQIIGLGTQVSQRPGAQALKIEAKLEHWYVTGLRQQDIVPSLVASIGDTTSSLLKIEFETNPENSPADQTLIVQSQPVEVIYDAKTINAVVEFFQSNKGLDLEQITSATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLIIPQTGFHHEKSNLLILDFGTFQLNSKDQGAQKTANASLEEIIDKAYDKFDVEIRSVQLLFAKAEENWKKCRFQHPSTMHILQPMDIHVELAKAMVEKDVRMAKFKVSGGLPLMHVRISDQKIKDALCLINSIPLPQKSSTPSPERQVASIPVLSGGTKALLGTSLLLDGVESESDEEFFDAEDGDSQAARTVKASELKKAAEVPNEELVSLLLKFEIKEVVLELTKQQKEEETILVFNVTQLGTEATMRTFDLTAVSYLRKISLDYHDIKGSRKKPIHLISSSDRPGLDLLKVEYIKVDRNGPSFQTTFEKTEQTVKVAFSSLNLLLQTQALLSSLNYLTTVIPSDSQNTGVAKEVQAMPEKQKNSPLQKVMVPSRDSDVIGFRLFAKLNAFCVTVCDEKSNIAEIKIQGLDSSLSLQSKKQSLFARLENIIVTDVDPKTIHKKAVSIVGNEVFRFNLDLYPDATEGDSYTDMSTVDGVVALHVGCIQIVYLHKFLMSLLSFLNNFQVAKEALSAATAQAAEKAATSVKDLAQRSFRVSVDIDLKAPVIVIPQSSLSTNAVVVDLGLIRVHNRFSLVSGEDTANPPVIDKMEVQLTKLKLSRTAIQPGTSHPDIQLLHPINLEFFVSRNLAANWYHKVPVVEIKGRLDSMNVSLNQEDLNLLFRILAENLGEATEDLDKGKPRIQERGETKACREVSTPQDVHTTQGVPAARVEETRPVDIINVLLNFEIKEVVVTLMKKAERKGSPFHELKILHLGMEAKVKAHDMTAAAYLRNISMRCFHFPDSKGEPLRIVNTSDVSDGILLKLLFIKADSDGPDFKTIHDNTKQKLKVSFSSLDLVLHLEALLSLMDFLSSAIPSSDSSSSEKEPELKPLVGESRSLAIRAVPSSYEGDAFDLKITAELNAFNIFICDQKSNIAEIKIHGMDASISVKPKQTDVFARLKNIIVMNVDSLSIHKKAVSILGDEVFRFQMSLYPDATEGENYGDMSKVDGRLSLKVGCIQIVYVHKFFMSLLSFLNNFQAAKEALSTATVQAAERAASSVKDLAQKSFRLLMDIDLKAPVITIPQSSVSPNVVIADLGLIRVENKFSLVSVEQLALPPVADEMSIQLTQLKLARTVLQADSPQHDVEILKPVNMLLCIQRNLSAAWYTQIPGMEIKGELKPMQVALSQDDLTVLMKILLENLGEASSQPSPTQYAQEAARVKRDTRSGPDYLKEQELADPKPPGDQTVTLQFDFHFDSLSIILYNSDSSQEPRLSFHNDSFRLGELTLHLMASAGKMFKDGSMNVSLKLKTCTLDDLREGIERATSRMIDKKNDQDNNSSMIDISYSQDKNGSQVDAVLDKLYVCASVEFLMTVADFFIKAMPQSPENIAKEIQIPSRQTAAGRVKMEKDDSVRPNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLSTSKLEQMMEASVRDLKVLACPFLRERRGKSITTVLQPCSLFMEKCTWASGKQNINIVVKEFVIKISPIILNTVMTIMAAMSPKTKEDEWKDTPKETDNLWAVKSITDYNSWFLGVDMATEVTENFRDSEHPSIEENCVVAVESVQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLMAAAADMTLEVHYYNETHAVWEPLIERVEGNKPWSLKLNVKKNPIQDKSLMPGDDFIPEPQTAVHISSGATMNITISKSCLNVFSNLAKGFSEGAASTFDYSLKDRAPFTVKNALGVPMKVQPNRNLKVMGSPEKSDIYDVGAGQHLELDYASLEPSRQGKLSILSRQESSLFTLTFVPYGYTEVASVPVARPGRRLYNVRNPSASHSDSVLVQIDATEGNKVVTLRSPLQIKNHFSIAFIIYKFVKNVKLLERIGIARPEEEFHVPLDSYRCQLYVQPAGGLEQQYTHSSTYISWKEELHRSREVRCMLQCPAVEVSFLPLIVNTVALPDELSYIGAHGEDWDPAYVIHLYPPLTLRNLLPYSLRYLLEGTAETHELAEGSSADVLHSRISGEIIELVLVKYLGKNWNGHFRICDTLPEFFLVCFSSDTAEVMTVDLSVHVRRIGCRMELSVFSPYWLINKTSRVLQYRSEEIHVKHPADFRDIILFSFKKKNIFSKNKVQLKISTSAWSNGFSLDTVGSYGCVKCPATNMEYLVGVSIKMSSFNLSRVVTLTPFCTVANKSSLDLEVGEIASDGSIPTNKWHYVASSECIPFWPENLSGKLCVRVVGYEGSSKPFFYNRQDNGTLLSLEDLNGGILVDINTAEHSTVITFSDYHEGSAPALIMNHTQWDVLTYKQSGSQEELVLLPGETRLFAWADPTGIRKLTWNYAANFGEHDLLKDECGQFPYDANIQIHWVSFLDGRQRVLLFTDDVALVSKALQAEEMEQADHEVALSLHSLGLSLVNNENKQEVSYVGITSSGVVWEMKPKQKWKPFSQKQIMSLEQAYSKRLASQDRGWVKLDSNFEVNFDKVPMEMRLPIRCPIKRDFLSGIQVEFKQSPHQRSLRARLYWLQVDNQLPGTMFPVVFHPVAPPKSIALDSEPKPFIDVSVITRFNEYSKVLQFKYFMVLIQEMALKVDQGFLGAVISLFTPTTDPEAERKRTKLIQQDIDALNTELMESSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMIAIHSVNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLMWSVVRHYSEQFLKQMYVLVLGLDVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLVGHTVGGAAGVVSRITGSVGKGLAAITMDKEYQQKRREEMGRQPKDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAGFFKGIGKGLVGAVARPTGGIIDMASSTFQGIQRVAESTEEVSSLRPPRLIHEDGIIRPYDRQESEGSDLLENHIKKLEGEAYQFHCAVPGNKRAVLMITNRRALFIKEVEILGHMSVDWQCLFEDFVCPPEVSENLLKISVKEQGLFHKKDSANIGHLRKIYLKDPITAKRAFDAIESAQSARQQQKLMRQSSVKLLRPQGPS