lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic granule. Cell membrane. Cell projection, axon. Synapse. Cell projection, neuron projection.
Domain:
The PAL motif is required for normal active site conformation; Substrates, such as NOTCH1 and APP peptides, are bound between PSEN1 transmembrane domains and via the first lumenal loop and the cytoplasmic loop between the sixth and seventh transmembrane domains. Substrate binding causes a conformation change and formation of an intermolecular antiparallel beta-sheet between PSEN1 and its substrates.
Sequence:
MADLVQNAANNVLNDGMDTSRHTSSTAAPPSRNEVELNGQPPTAPPPQVVTDSEEDEDEELTLKYGAKHVIMLFIPVTLCMVVVVATIKSVSFYTQKDGQQLIYTPFREDTETVGQRALHSMLNAIIMISVIVVMTLVLVVLYKYRCYKVIQAWLFFSNLLLLFFFSLIYLGEVFKTYNVAMDYFTLALIIWNFGVVGMICIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAAISVYDLLAVLCPKGPLRILVETAQERNEAIFPALIYSSTMVWLFNMADSAETRNNSSHPVPQQENQVVAMAPTAQAEDDGGFTPAWVDHQQHQLGPMQSTEESRRQIQEMPSARPPPPADDDEERGVKLGLGDFIFYSMLVGKASATASGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDNLVRPFMDQLAVHQFYI
The following text describes a protein:
Function:
Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development.
Subcellular Localization:
Cell junction, adherens junction. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MEPETPEKEDSAPQIVSTTSQPDDDANDGKEKAEPEGKEELVETHQLQVAEEMAKEIKKKIRKKLKEQLTYFPSDTLLHDDKLGSEKRKKKKKKVPVPSKPEPSASDICDNAVEDEQKKECPLETVTLVSHHDEEIRPTEQNADDNKPDNKKPKPKKTKKKTKAVSGNEDMNGDGVHEITSRDSPIYPKCLLDDDLVMGVYIHRTDRLKSDFMICHPMVKIHVVDEHTGQYVKKDDSERPVSSYYERDNVDYILPIMTQPYDFKKLKSRLPEWEEQIIFNENFPYLLREFDECPKVILFFEILDFLSMDEIKNNSEVQNQECGFRKIAWAFLKLLGANGNANINSKLRLQLYYPPTKPRSQLNVVEVFEWWSKCPRNRYPSTLYVTVRGLKVPDCIKPSYRSMMALQEEKGTPVYCERHRETSSVDTEPGLEDSKEVVKWKRLPGQACRIPNKHLFSLNAGERGCFCLDFSHNGRILATACASRDGYPIILYEIPSGRFMRELCGHLNIIYDLDWSKDDRYLVTSSSDGTARVWKNEINSTSTFRVLPHPSFVYTAKFHPATRELVVTGCYDSMIRVWKIDSREDGPILVRQLDAHKSFVNSICFDEEGHHMYSGDCIGVIVVWDTYVKVNDVQHSVRHWTINKEIKETEFRGVPISYLEVHPNGNRLLIHTKDSTLRIMDLRILAARKFVGAANYREKIHSTLTPCGTFLFSGSEDGIVYVWNPETGEQVAMYSDLPFKSTIRDISYHPFENMVAFCAFGQSEPVLLYVYDFHVAQQEAEMFKRYNGILPLPGIHQSQDALCTCPKLPHQGSFQIDEFVNNENNSSRKIQLVKQRLETVTEVIRSCAAKVNKNLSMTSPPPGPPRKPRVKQSFVLTTDEIIHQFGVPQTAFINIEKRHFMRQADPPPMVVALYDYTASRSDELTIHRGDIIRVFFKDNEDWWYGSLGKGQEGFFPANHVASESKCMLSSCTLRCKTEPKIDHFLPCN
The following text describes a protein:
Function:
May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSGPIQSLKKTKRVPLVPSNQKEGNLYSLPKQEDNEEQITKKRIAPFRNTQVQRTDEELYAQEMNKKFSDYLQKEIVNDIQHDRSSRKSPRGDSEADADLMSVMLKRLTTTEKQLALAKQDGAEKDKRIRHLEFQVKQLKLKNARNDDEESYRELKAKCVTLQRQVHEMERFLNDYGLVWIGDDESEDDEDSSTQDNSEKQNTASTTMWQPEQSLATATAIDFNLVIENIKELNLLANADNPKIVKTTGRAVFQIPDAIPISIYSNGFALYEGPFRYYDEPYAQQFIRDICDGYFPSELQSRHPDGVPFQIYDHRETEYRNQRLDNFPGLGNILGGKSNPPGNMVSRRDKVKVTSKLAGKPVTVDKFLSKLPESVIRDGKIVNIRSDIKENIQTSDSTKSKVVIVETKQVKDMKVKHADESERPATPHDITTLRIKNEDNSQGILVFANTRLRDMYLKAVKLYLFNFTIQDLYKYISNQRSSSEPPFEIRSSFPKKLYTDMDATLYESGLTPNATLFLTANKLK
The following text describes a protein:
Function:
Hydrolyzes 1,4-beta linked polysaccharide backbones of mannans. Hydrolyzes mannohexaose (M6) preferentially to mannotriose (M4) and less preferentially to mannotetraose (M3), mannopentaose (M5), and mannobiose (M2); hydrolyzes M5 preferentially to M2, and M3, and less preferentially to mannotetraose M4; hydrolyzes M4 preferentially to M3, and less preferentially to mannose (M1), plus very little M2. Does not hydrolyze mannobiose or mannotriose. Does not hydrolyze xlyan, starch, cellulose or galactose.
Sequence:
MLLTALAVLFASTGCQARLSVSGTNLNYNGHHIFLSGANQAWVNYARDFGHNQYSKGKSTFESTLSDIQSHGGNSVRVWLHIEGESTPEFDNNGYVTGIDNTLISDMRAYLHAAQRHNILIFFTLWNGAVKQSTHYRLNGLMVDTRKLQSYIDHALKPMANALKNEKALGGWDIMNEPEGEIKPGESSSEPCFDTRHLSGSGAGWAGHLYSAQEIGRFVNWQAAAIKEVDPGAMVTVGSWNMKADTDAMGFHNLYSDHCLVKAGGKQSGTLSFYQVHTYDWQNHFGNESPFKHSFSNFRLKKPMVIGEFNQEHGAGMSSESMFEWAYTKGYSGAWTWSRTDVSWNNQLRGIQHLKSRTDHGQVQFGL
The following text describes a protein:
Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
Subcellular Localization:
Nucleus.
Sequence:
AWGHFISTALTDAIEKAMESDVKFRRGLPINFVSQLGLGMDIQGDDEKAIASKKENESFKKQLKELLIALVDHVDANETSDKMASDFMASRLPPFETEKDEKAKSEKPTADSEVKFLYPEYVRVTSGEAAPSGPIIALADSNSEDSEEGEESDDEGSDDEDMEVSEGEKKSKKKSANAENGGDKASKAKKEKKGDDDKEAKSKKEKKTKNGGKVDGKKTKKGKKKEESEEEEEKSEEEKKSKKKTKTKKGKKEKQESESEEESDAEYELGTEDSSEDSGEESGPDSEDEESGKAWVLVHHSLNNDRSHHMMGMPEPSVLKFAVTYQDALLLLYRKRHEFIPVKSLPLDSEEALYLVNSLWAEGLLQAK
The following text describes a protein:
Function:
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MDEFLHKALYVVETDEDIDFESAPSTGQEYLRRVIVESRKCEAVVVADMKEILKGKKLKAQTVKYTTDSGCPPAPEVFLPSKEWQQFQVSQFSCLRSRMAKHLARLKKQGIQMKPNTTLPDGDKEKEWSVLCYGNPEDEKYCGTPPMLPIILSLNQFMVETLLEYNVQWLEETNFTQQRGQWLYALLAKLEKPLKPEMCSLIRTLARLCSTFRVQLTSVDDPLLAQLNLFICLVGRYFDQSDLADPMK
The following text describes a protein:
Function:
Deubiquitinating enzyme that regulates the degradation of various proteins by removing ubiquitin moieties, thereby preventing their proteasomal degradation. Stabilizes RNF123, which promotes CDKN1B degradation and contributes to cell proliferation. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates (By similarity). Mechanistically, deubiquitinates and thereby stabilizes several E3 ligases involved in the ERAD pathway including SYVN1 or MARCHF6 (By similarity). Regulates the stability of other E3 ligases including BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia by rescuing HIF1A from degradation in a non-catalytic manner and by mediating the deubiquitination of FUNDC1. Attenuates mitochondrial damage and ferroptosis by targeting and stabilizing NADPH oxidase 4/NOX4 (By similarity). Negatively regulates TNF-alpha- and IL-1beta-triggered NF-kappa-B activation by hydrolyzing 'Lys-27'- and 'Lys-63'-linked polyubiquitin chains from MAP3K7 (By similarity). Modulates also the protein level and aggregation of polyQ-expanded huntingtin/HTT through HSP90AA1 (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Accumulates in the mitochondria-associated ER membrane (MAM) in response to hypoxia.
Sequence:
MSAGTSATGPRRGPPGLEEATSKKKQKDRANQESKDGDPRRVSMPRKEPTKDELLLDWRQSSDKVVVKLRVGTGPICLEEVDAAFTDTDCVVRLPDGRQWGGVFFAKIQSSCTKVQTRKGGLLQLALPKKVPLLTWPSLLKKPLGTQELVPGLRCQENGQELSPIALEPGSEPRRAKQEARNQKRAQGRGEVGSGASPGAQAGPSAKRAVHLCRGPEGEGSMDGPGPQGDAPSFLSDSATQVEAEEQLHVPPVNPQTSLLGSEKNLALLTVEKTVSPRSDSVSPVMIRNRDPEKDDHFKEEMAVGADPAALADEPESMVNLAFVKNDSYEKGPDSVVVHVYVKESRRDTSRVLFREQDFTLIFQTRDGNFLRLHPGCGPHTIFRWQVKLRNLIEPEQCTFCFTASRIDICLRKRQSQRWGGLEAPATRVGGAKVAVPTGPTPLDSTPPGGGPLPLTGQEEARAVEKEKPKARSEDSGLDGVVARTPLEHVTPKPEPHLASPKPTCMVPPMPHSPVSGDSVEEDEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHQAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQKVLPIYYFAREPHSKPIKFLVSVSKENSSASEVLESLSQSVHVKPESLRLAEVIKNRFHRVFLPSHSLDAVSPTDVLLCFELLSPELAKERVVVLEVQQRPQVPSIPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQFCQKTHWPDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTSSLEAGDSEREPIQPSELQLVTPVAEGDTGAHRMWPPADRGPVPSTSGISSEMLASGPMEGCSLLAGERVSRPEAAVPGYQHSRESVSAHTPQFFIYKIDASSREQRLEDKGDTPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPSDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPRAAHAEHHPDLGPAAEAAASQASRIWQELEAEEEMVPEGPGPLGPWGPQDWVGPPPRGPTTSDEGCLRYFVLGTVAALVALVLNVFYPLVSQSRWR
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MFQQNKHHQQQQQQQQQQGVVQSGVASATVNNPSESIVAGNIYECSLHGILSTPSSTFIQRAKGMMRCEHPVSYKEMVFKSTVQSAGPSWAEGSILPSEIHVRYEKNTVYVRYVGVPQIKDNINAMIRNVVDIKSSETFFIYLENLGYVKDYEYFVDGYQYSTYNLSLFLVNHRRVLNDGTKGELLNKHSMVELQCLSGEEGFVAAAEYLNTYAEYLYPFVELIKFDHRLLTAENSNTPTTNVNVVGGYNR
The following text describes a protein:
Function:
Vacuolar phosphate transporter that probably exports phosphate from the vacuolar lumen to the cytosol.
Miscellaneous:
MISCELLANEOUS: Present with 4280 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MKFSHSLQFNSVPEWSTKYLAYSQLKKLIYSLQKDKLYSNNKHHVVEPHDANDENLPLLADASPDDQFYISKFVAALNQELKKIDKFYISQETGLIANYNELKDDVMELENTNKATQLFNQQQQHQLQSVARNRKSKSQQRQRRFSSVSSTDSNPSLTDMSIDSAPVIHTQVSNTTNNGNSMQNLASASVSLSNSNPVYLSPFTQHRLSLKKRLISIYTQLSELKDFIELNQTGFSKICKKFDKSLNTNLKQNYLNYIKFHSHVFNPATINRIQHHITETILTYASLNKGTRRPSNTFNLDADRINNDENSSGNEEDEDGNRQEVLDFQDAERELSSHLRDHVVWERNTVWKDMMNLERKYQSAKTDNKKFSKLSSSQLRPNANITESMAMSSGGAGIIAPSTDSLTFRELMHLPPKQWLQFIMGQTSLLKFLLITSCFIALLTFNLTPFTQDSLQKNCFAILIYASLLWATETIPLFVTSLMIPLLIVVFPVIKDPITSQPMSPRDSSQFILSTMWSSVIMLLLGGFTLAAALSKYNIAKVLSTHILASAGTNPHFILLTNMFVALFVSMWVSNVAAPVLCYSIVQPLLRTLPRNCSYAKALILGIALASNIGGMSSPIASPQNIFSIGIMDPSPSWAEWFMIALPVCFICVMAIWVLLIITFPPEPNVKILQLHPSRDPFTLKQWFVTLVCIITIVLWCLSNQISGIFGEMGIISIIPIVVFFGTGLLTSDDFNNFMWTIVVLAMGGTTLGKAVSSSGLLSTMAQLIKAQVEHEPIFIIVLIFGLVILVMATFVSHTVAAMIIVPLMSEIGSNLPSGDHSRLLIVIAALLCSSAMGLPTSGFPNVTAISMIDEVGDRYLTVGTFITRGVPASLLSYAAIVTVGYGILKVMGF
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MPPKPKHRDVAGFLSRVRNFLLGRTHKTAHRFADMVSPRTQPPPNIPSGPTQSLFANYYYTRDPRRLVKPFVDVVQEHKKMLTAKVKEEEAAKKAQAKSGDAPKDGSPIPPVGPKTTDTNECDEGNSGAKKLPTPGKVHSWEGPH
The following text describes a protein:
Function:
Cofactor for the transcription factor TCF7. Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T-cell fate.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Continuous nuclear export is followed by degradation.
Sequence:
MRDPVSSQYSSFLFWRMPIPELDLSELEGLGLSDTATYKIKDSSVGKMIGQATAADQEKNPEGDGLLEYSTFNFWRAPIASIHSFELDLL
The following text describes a protein:
Function:
Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes.
Miscellaneous:
MISCELLANEOUS: The active site is a redox-active disulfide bond.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MSEKQYDLVVLGGGTAGYVAAIRASQLGKKVAIVERQLLGGTCLHKGCIPTKSLLKSAEVFQTVKQAAMFGVDVKDANVNFENMLARKEDIINQMYQGVKHLMQHNHIDIYNGTGRILGTSIFSPQSGTISVEYEDGESDLLPNQFVLIATGSSPAELPFLSFDHDKILSSDDILSLKTLPSSIGIIGGGVIGMEFASLMIDLGVDVTVIEAGERILPTESKQASQLLKKSLSARGVKFYEGIKLSENDINVNEDGVTFEISSDIIKVDKVLLSIGRKPNTSDIGLNNTKIKLSTSGHILTNEFQQTEDKHIYAAGDCIGKLQLAHVGSKEGVVAVDHMFEGNPIPVNYNMMPKCIYSQPEIASIGLNIEQAKAEGMKVKSFKVPFKAIGKAVIDSHDTNEGYSEMVIDQSTEEIVGINMIGPHVTELINEASLLQFMNGSALELGLTTHAHPSISEVLMELGLKAESRAIHV
The following text describes a protein:
Function:
The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.
Subcellular Localization:
Nucleus.
Sequence:
MSGCHQTAGPYFNICSNTQIYLIYVIKWRSVVNFVNNSDRFRAREVPDGLETAVSDPTDVRVTHSVLFRRRPLTLDTPPTTTNFSTYLQRFEQPNQNSLRPPPPTSMANPQDEEEAIFGTDRPDPNEGPSKGAHLEEEEDEEDEEEDEEDDEEDDDDDEEEDGRGKPRKRRKRTRNKYIDDLADVDDEEEEEEEEEDGLGGPEDDFIDRNEIPEGDRSSRRNLLRDITGDDIDAGHRGLDMTRQVREDADLGQIAQDFRERYGRQSRVAARDLGEHIPKNLLMPCDQDPSIWAVKCKPGREKEIVAALFRKCEVHYKTPQQLNIISAFYRDSLKGYIYVEARLESDVREAIQGFVGVYKSEFRMVPMDEMPDLLRTKKRETPIVPGGWVRIKRGKYNGDLAQVTEVLENGDEVGLRFVPRIDLNPKEDGVKVGPDGKKRKKGNTTSGGIAFRPPQKLFNAEEVKKAYKPGDVTRSQRGGYSFHGDLFREGYIEKDLKISALEIVDVNPRIDEIAKFLGDPSDSDPSRTLNLSQIAELTKKAGTAVLQPGDHIEVFEGDQKGIQGTVESIEKENVNILPDPLAHPDLKGAKIEIPASSLRKSFKPGDHVKVMAGQNTDETGLVIRVREDVVTFLSDLSCKEVESFARDLRVAAEVGSSANTFGQFELYDLVQLDPQTTGVIFKIERNTFKVIDQNGNVRSVKPNQISAKKDSKYAIATDADGYEIAVNDQMKEKSVGGRTDGRAGRVLHIYRSMYAFLHSHDTTENGGVFVTNARNLVSVAPKGSKKDSGGLDLTKMNPEMANRPPVGGAMVAAGLGQRFKRDEDIGKLCYIIKGPNKGLQGIIKDINGLLARVELHTNNKTLTIEKTKLGAKGRDGKVHPLADLARENFSSSSRPGGFGSSGGNRSSYGGPTGSNSVRHGGQSVHSGIGGATPAWGASGGRTSNPYADGSRTSYPSDGGRTSNPYTDGGRTPAYSTSGAWDPGSKTAIASGYGSTNGWDAAEQSYNSSAQTPAQRTDIGTPHDPWGSRTPAQAPTPRVDRHAPTPGTSSNLTRGDRSERREEGSMSSWGNPAGVTPFAAAPTPTAYGGRGGNIAPTPNAPTPGGLTPYGAAPTPAPYGAAPTPVGYGNAPTPAAYSAPTPVAYGSAPTPAAYGSAPTPAAYGSAPTPYSSNPNFTAASPAGPYNHGTNAATPYTAATPGGGLVNQHPSALMGISHMGLPENWPVPGIEVAIIRPREGPSFNGSRNDDEHVVVLGSAGTHRNGPYNVKCLSSNARIPPVPIEFLEPVPPRAPGDPVVILQGIYRTKRATTISRDASDWMVQLETGEQTIVESSHLAIYKGC
The following text describes a protein:
Function:
May be involved in the endocytic machinery.
Subcellular Localization:
Cytoplasm. Membrane.
Sequence:
MCSTNPGNWVTFDDDPTFQPSQKSKNLPLENQGICRPNGLKLNLSGPKEFPRGPSSTGSSPLSSPIIDFYFSPGPPSNSPLSTPTKDFPGIPGIPGIPKTGTHVLYPIPESSSNSPLTIPGAGSSLLPTKPTCLSHASLPNDHSCTHPAPKVGSPNENSPHQAESLGLQNNAPQFQYFREDCAFSSPFWKDEGSASQFTFDPPGSRKMFPSKDKEMPIDQKSLNQCSLNYICEKLEHLQSAENQDSLGNLSMKCLCAEDTASSFVPHTLFRSQPKTGWSFMLRIPEKKNMMSSRQWGPIFLKVVPGGILQMYYEQGLEKPFKELQLDPHCRLSEPKVENFSVAGKIHTVKIEHVSYTEKRKYHSKTEVVHEPDIEQMLKLGSTEYHDFLDFLTTVEEELMKLPAVSKPKKNYEEQEISLEIVDNFWGKITKEDGKLVESAVITQICCLCFVNGNMECFLTLNDLELQKRNERYFEKDSEKKGIDILDYHFHKCVKDQEFEQSRIIKFVPLDACRFELMRFKTSYNGEDLPFSLKSVVVVQGAYVELQAFVNMAPLAQRPSHASALRSCDNIMIHFPVPSQWIKALWTMNLQRQKSLKAKMNRRACLGNLHELESEPVIQVTVGSAKYESAYRAVVWKIDRLPDKNSKLGSDQEIPSDWYPFATVQFGMLDTCASGTEVRSLGVESDVQPQKHIHQRACYNIQVEIEKKWIKIDGEDPDKAGDCVTQ
The following text describes a protein:
Function:
Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.
Miscellaneous:
MISCELLANEOUS: Present with 1320 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTKKKAATNYAERQNLASEDSSGDSVHFKDFIPLQELLKDKNYVPSVENLEKILYNETMFNDQKICSNLLLEALIITLFTTISGKSALRLIQTSSLKERKSWAQSFENNSSSYASIVLSWKDNDILLLKFLRFLLANKTAPLQINRYNLPEYKLPLSFLIVSKITIPSILLNETYNLLKDYLYSITGRIESLISCSSTFDKPALVVRKILKDYNRMIECRNFYFWYSFNAENRVNLTFSDNISLLMENDEGNAGSGLDDSRFDHQKQPREAIMGRTINDQEQIYSFELNQDGTLEIPNVMEHSLLRHELLFKILNLTTVLTPLLELQFSTLCGLVDPLMQPTPNDKHIISIDFLFQLFLGLMSQSIKTSQEHNDHYDWKFYMCFNMQKIIDATMLRLNCFDFDILNSVNNTDNAVHWKTQLHRWLPHGLNTQDLELLYMIDILAVYTIYKLYEKIPIQLNPFLFSLISLWKNLSCVILLALEIDRIEEENGTYETPLMVRATIRGAAALRSVIATVLNGLVKNNDHDFKHESLNTFMSPYGRKLCHGALYADLRSHTASLLALGASIEDVTDLFADLQSGDRFDEDIRYMFDYECEDYDESFSESDHGGLDESVVNPTEKIASGSNNVFFRRRCNCIFNDDKLVAEDGANEAFGSTNSENVEGAMHNNRNAVHNATTATSDHVVTSPNPLSVRSRSTFEFDYSGEDWRDVPRDFNMYYSPSYSFIHEPKLDVIFSLTLRGATEKLNKEESILLVRSVASCVRNEQDQMILADLESNFSASINGDVEGEGNTKMSKIDNEDLRRTTPDDIYEIWSEESAFERMLNVNHDVAWRLMDEMLMCTGYRRILIWFLTHLELKHSLIYYVFELIMGLRGKPFSGEASDQDKKDDMIYEILKKKQKNEDASGLPFSRQGPIVLSDIETKMLLQEFFMNAAIFLSSKNNEEENEDGEKISLYSLGLVRLICYMVQTLIANDKFFFTKSECTFELQTLLMTWIGILPEAKDLFFKIKTRLAMEEEDSADTMQHEGRKNSDIEKKLNAKPASELNLKLLNLFPSKPANKDDSSPINTLRSFIADYSFDTQVNPPGRRVVFYDGKILPLPKADKPIPLHEYITLAELDVGDSE
The following text describes a protein:
Function:
Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1 (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Note=Localizes specifically to very distally located appendage structures on the mature centriole from which initiate PC formation. Persisted at centrioles throughout mitosis (By similarity). In response to DNA damage, it translocates to nuclear foci that contain the DNA damage response proteins KAT5/TIP60 and CHEK1 (By similarity).
Sequence:
MARRPILLGDQLVLEEDSDETYVPSEQEILDFARVIGIDPIKEPELMWLAREGIEAPLPKGWKPCQNITGDLYYFNFDTGQSIWDHPCDEHYRKLVIQERERWSAPGAIKKKDKKKKKEKKNKKDKETSKSPLVLGSPLALVQAPLWGLAPLRGLGDAPPSALRGSQSVSLGSSADSGHLGEPTLPPQGLKAAACAKGLLASVHEGKNALSLLTLGEETNEEDEEESDNQSVRSSSELLKNLHLDLGALGGNFEYEESPRTSQPDKKDVSLDSDADRPPTPGKLFSQGADSSVASANGSKSQGRGASPWNPQKENENSDPKASSSQMAPELDPGGDQPSRASKKQQAEDPVQAGKEGECRRESAAKEPKEASALENTSDVSEESEIHGHLKDARHSGSEASGPKSFLGLDLGFRSRISEHLLDGDTLSPVLGGGHWEAQGLDQEEQDDSKSSIAEPQSKHTQGSEREHLQSSLHSQATEEGPLQTLEGQPEWKEAEGPGKDSVASPAPLSLLQREQVLSPPASPERAEEKHSQAEELGLEQPEAEETEEKVAVCPSSPVSPEVQTAEPAAPQKLFSEAILKGMELEEDQRLLLEFQKEKPQQLEERLWEEEEEEVCQLYQQKEKSLSLLKAQLQKATAEEKEKEEETKIREEESRRLVCLRAQVQSRTEAFENQIRTEQQAALQRLREEAETLQKAERASLEQKSRRALEQLREQLEAEERSAQAALRAEKEAEKEAALLQLREQLEGERKEAVAGLEKKHSAELEQLCSSLEAKHQEVISSLQKKIEGAQQKEEAQLQESLGWAEQRAHQKVHQVTEYEQELSSLLRDKRQEVEREHERKMDKMKEEHWQEMADARERYEAEERKQRADLLGHLTGELERLRRAHERELESMRQEQDQQLEDLRRRHRDHERKLQDLEVELSSRTKDVKARLAQLNVQEENIRKEKQLLLDAQRQAALEREEATATHQHLEEAKKEHTHLLETKQQLRRTIDDLRVRRVELESQVDLLQAQSQRLQKHLSSLEAEVQRKQDVLKEMAAEMNASPHPEPGLHIEDLRKSLDTNKNQEVSSSLSLSKEEIDLSMESVRQFLSAEGVAVRNAKEFLVRQTRSMRRRQTALKAAQQHWRHELASAQEVDEDLPGTEVLGNMRKNLNEETRHLDEMKSAMRKGHDLLKKKEEKLIQLESSLQEEVSDEDTLKGSSIKKVTFDLSDMDDLSSESLESSPVLHITPTPTSADPNKIHYLSSSLQRISSELNGVLNVLGSLNSQPPPQGLGSQPPPPLFTSSLRSSKNVLDPAYSSQAKLSSLSSITPMSTQWAWDPGQGTKLTSSSSSQTVDDFLLEKWRKYFPSGIPLLSGSPPPPENKLGYVSVSEQLHFLQRSHPRVPRTDGVSIQSLIDSNRKWLEHFRNDPKVQLFSSAPKATTTSNLSNLLQLGLDENNRLNVFHY
The following text describes a protein:
Function:
Synthesizes trehalose 6-phosphate, the precursor for the production of trehalose, the main carbohydrate storage reserve of the dormant spore. Trehalose accumulates in both prestalk and prespore cells and then is rapidly metabolized during terminal differentiation of stalk cells, while being stored in spores, where it serves as the principal energy and carbon source for germination.
Sequence:
MNENDNNLENETGFSGRLIVVSNRLPVSIKKESNGKWSCKMSSGGLVAALSGLKSNFIWVGWIGAEIEEDDRKEIKELLWKDYSCIPVFLSEKVANEHYNGFSNGVLWPLFHYLPGDLDYDDRIWNSYVEANEQFSSVVAEILKPNDLVWVHDYHMMLLPEILKQKKPDARIGFFLHIPFPSSEIFRVLPCRKEILLGILNCCLIGFHTYDYARHFLKSCTRIVGLETAPNGVYFKDRFVQVGVFPVGIDPDKFFESLKTTQVQNRIKELKESFEGTKVLIGIDRLDYIKGIPQKLQAIERLFQKYPEWKGKLVLIQVAVPSRQDVEEYQKLKKEVEELVGRINGLYGSIGYSPIHYLFQSVDPSELTALYNISDAALITSIRDGMNLVAQEYIVCQTENNGVLILSEFTGAAQSLSGAVMINPWNTEEVADSIHNSLLMPPEEREEKHQMLLKYVTKHTASHWGLGFVKELNKASSNTDKMVTIQKLDIEKVVDIYKQSKRRLLIFAYDGTLIPYNNVPQLSRPSQELLNSFDILSNDPKTDVYILSGRDKKTLSEWFLGIQIGLSAEYGCFFKLPESTEWEQQVPSMDLSWKETIRPLFKYFTLRTPGSFFEEKEMLFTWHYRNADPIFGSIQARELHLHLDNLPLDVIVGDKTLGVRSYNINPLSSMKKVITDTIPKGLDLILLIGDTHIHPSELPTFDGKIFNISVGKKSVKDSYHLSDPAEVNYLIIN
The following text describes a protein:
Function:
Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates high salinity- and dehydration-inducible transcription. Promotes the expression of heat stress-inducible genes by contributing to the formation of a heat stress-specific transcriptional complex with NF-Y subunits (e.g. DPB3-1, NF-YA2 and NF-YB3) at the promoter of target genes, thus promoting heat tolerance.
Subcellular Localization:
Nucleus.
Sequence:
MAVYDQSGDRNRTQIDTSRKRKSRSRGDGTTVAERLKRWKEYNETVEEVSTKKRKVPAKGSKKGCMKGKGGPENSRCSFRGVRQRIWGKWVAEIREPNRGSRLWLGTFPTAQEAASAYDEAAKAMYGPLARLNFPRSDASEVTSTSSQSEVCTVETPGCVHVKTEDPDCESKPFSGGVEPMYCLENGAEEMKRGVKADKHWLSEFEHNYWSDILKEKEKQKEQGIVETCQQQQQDSLSVADYGWPNDVDQSHLDSSDMFDVDELLRDLNGDDVFAGLNQDRYPGNSVANGSYRPESQQSGFDPLQSLNYGIPPFQLEGKDGNGFFDDLSYLDLEN
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MPNLGAPEILIILLVALLVFGPRKLPELGKSLGAGLREFRRSTQGLKEEFDGAMRDAGPAAPAPAQVQVIAAQPQVEAGQGTPVAAAAVTPQQVTPQAVAAAVAPVQAVPEPVKQEG
The following text describes a protein:
Function:
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSEVVRNTLVKLQAIIALIGLAAITPLLILVALLGRLIAKLCWCSAPKSIAGEVAVVTGAGHGLGRAISLELAKKGCHIAVVDINVSGAEDTVKQIQDIYKVRAKAYKANVTNYDDLVELNSKVVEEMGPVTVLVNNAGVMMHRNMFNPDPADVQLMINVNLTSHFWTKLVFLPKMKELRKGFIVTISSLAGVFPLPYSATYTTTKSGALAHMRTLRMELDLENQKDIHVTTVLPSFLRTNSDVTQLTHTIGFGDVYPLFTGEEVAQRIVAGMVRGEAEITVPGMACLLYRVILILPADWQDRIILLFSRNKFKKLRDEHS
The following text describes a protein:
Function:
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of cichorine, a phytotoxin active against knapweed, corn, and soybeans. The first step in the pathway is performed by the non-reducing polyketide synthase pkbA that condenses one acetyl-CoA starter unit with 3 malonyl-CoA units. PkbA also catalyzes one methylation step to produce 3-methylorsellinate. The nonribosomal peptide synthase-like protein cicB, the cytochrome P450 monooxygenase cicH and the O-methyltransferase cicE are involved in the conversion of 3-methylorsellinate into nidulol. CicB converts 3-methylorsellinate to a yet unidentified intermediate, cicH may play a ring-closing role for cichorine and cicE is plausibly responsible for the methylation of one of the phenol groups (Probable). The oxidoreductase cicC acts downstream with still unidentified enzymes to further convert nidulol into cichorine.
Sequence:
MERFPRSAADAQQLLQLAELFKQSAEIIAEEWNKEDFSRIKAETNSIKSNLGSLDTARILPSPRLHEATRTVLAITGAATELVAEPYSRIQEVACQYFESRALFVAAERRIPDLLAGAGEYGLSVGEIAEATGIEERKLSRILRCLCSIHIFRQIGTDRFANNRISAALKNNEPLRAYVQLFNLDIYTASDQLPKYLLSSQGASYKVHETAWQKAVGTTKARWDWLAERVSLDEVRPKEAPYPGLPDVRHLQPGPDGKYARPELDNFGLAMVGGGKVSGAAHAYDFPWASLGDALVVDVGGGVGGFVLQLLPAYPQLRYIVQDRAEVLQQAQEEIWPVEAPEAVADGRVQFMEHNFFQPNPVKGADVYWLRGIFYCVQILSALRTSMAPTSRILVCDQVMNTTAGCDEIPPAPSPLPANYGYYMRYPHHRDLAMMSIINGIERTPAQFTELVKQAGLKVNKIWNCRSMVGIVEIGLKNEKDRHHRRLSYMGFGNYTQLGIGFFSSAKGPVRDELQADEQA