lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in regulation of glutamate metabolism. Acts as a phosphorylation-dependent molecular switch that modulates the activities of Kgd, Gdh and GltB.
Sequence:
MTDMNPDIEKDQTSDEVTVETTSVFRADFLSELDAPAQAGTESAVSGVEGLPPGSALLVVKRGPNAGSRFLLDQAITSAGRHPDSDIFLDDVTVSRRHAEFRLENNEFNVVDVGSLNGTYVNREPVDSAVLANGDEVQIGKFRLVFLTGPKQGEDDGSTGGP
The following text describes a protein:
Function:
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
Sequence:
MNQKSIVWSIGGSDCSGGAGCQADILTCRDFNVHAASIITTITAQNAEQVLKINYCDSDLIQKQIQALKETLPPTVIKLGLLGTKEIVTAVASYLKNYSGKVVCDPVLNSTSGVLLHASDYLDLLKKLLFPHVDLLTPNIPEAEILIQNKIHTFSDIISAAHQLLKCGVSAVLLKGGHLIGSKARDFFTDGKCEFWLAHTKIPKTRVRGTGCALSSAISSAIALGYSLKDAIVVAKMYVQQGIRQNFKVNTQELMGRQGFPRRSIDLPWVTKNANFKRKSFPLCNSFGFYPIVDSVEWVERLLSYGVRTIQLRIKNASPQKIKKAVIESVALARHYQAKLFINDYWKLAIEAGAYGVHLGQEDLETADLSAIRAVNLRLGISTHTLYELSRAHAIQPSYVAFGPIYETYSKPMPYSARGLEWLRYWCEISPYPVVAIGGINLNRLESVLNAGAVNVAVISAVTKSKTPQKTVRAFLNRI
The following text describes a protein:
Function:
May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm.
Subcellular Localization:
Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Lysosome.
Domain:
The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
Sequence:
MATPYVPVPMPIGNSASSFTTNRNQRSSSFGSVSTSSNSSKGQLEDSNMGNFKQTSVPDQMDNTSSVCSSPLIRTKFTGTASSIEYSTRPRDTEEQNPETVNWEDRPSTPTILGYEVMEERAKFTVYKILVKKTPEESWVVFRRYTDFSRLNDKLKEMFPGFRLALPPKRWFKDNYNADFLEDRQLGLQAFLQNLVAHKDIANCLAVREFLCLDDPPGPFDSLEESRAFCETLEETNYRLQKELLEKQKEMESLKKLLSEKQLHIDTLENRIRTLSLEPEESLDVSETEGEQILKVESSALEVDQDVLDEESRADNKPCLSFSEPENAVSEIEVAEVAYDAEED
The following text describes a protein:
Function:
Putative NADP-dependent oxidoreductase that acts as a positive regulator of chloroplast division. May play a role at an early stage of the division process.
Miscellaneous:
MISCELLANEOUS: Plants silencing GC1 show greatly enlarged chloroplasts containing densely packed thylakoid membranes in mesophyll cells and leaves with decreased rates of CO(2) assimilation.
Subcellular Localization:
Plastid, chloroplast inner membrane; Peripheral membrane protein; Stromal side. Plastid, chloroplast.
Sequence:
MELLCSPTSLSSSFALSSALLVPRSFSMPGTRRFMVLCSSQKESQMTVSVTGATGFIGRRLVQRLRADNHAIRVLTRSKSKAEQIFPAKDFPGIVIAEESEWKNCVQGSTAVVNLAGLPISTRWSPEIKKEIKGSRIRVTSKVVDLINNSPAEARPTVLVSATAVGYYGTSETGVFDENSPSGKDYLAEVCREWEGTALKANKDVRVALIRIGVVLGKDGGALAMMIPFFQMFAGGPLGSGQQWFSWIHVDDLVNLIYEALTNPSYKGVINGTAPNPVRLGEMCQQLGSVLSRPSWLPVPDFALKALLGEGATVVLEGQKVLPVRAKELGFEFKYKYVKDALRAIMQ
The following text describes a protein:
Function:
Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MFFLQDPSLFTMGMWSIGVGALGAAALALFLANTDVFLPKSQKAALEYLEDTDLKTLEKEPRTFKAKELWEKNGAVIMAVRRPGCFLCREEAMDLSLLKPKLDELGVPLYAVVKEQLSTEVEDFQPYFKGEIFLDEKKKFYGPQRRKMMLLGFVRLGVWRNFFRAWDRGISGNLEGEGFILGGVFVVGSGRQGILLEHREKEFGDKVNVDSVLEAARKIKPQTLASEEK
The following text describes a protein:
Function:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). May play an important role in metamorphosis.
Subcellular Localization:
Nucleus.
Domain:
The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
Sequence:
MASTSNLLDVVRHYQRSIEKHGEDEQRLLHCITKLFNLPIKFEHLQETGIGKTVNALRKISGEVGVAAKTLVTKWKAMVAKEDPSIASTPTAIHNEEDSGKTKSSDEDPDQENKGGNSSSGEDLNTSKHKSKHAKSTKHERSSSSRSHSKSRSDSDKKHKSSRHDKSKDRDKDREGQKEAKEHKEKKSNGEHKSKDSSKSSSSHKSSKSESHKSEHTKSKHEKDKTSHSELKEVKDKSSKHKSSSSKSSKRSHSPPRHEEESQKAKIPKVKSKSEEDSADGFDSSMGANFDDVLGLLNIPISSKKSSSNSKSKFVAKPTAAPSSSALSAPTTAGSSKEALSTSSRPTSKKPELLASTAKLEPLDPNIALELPTISNNYKPMPLNQTVMDVVFNQGGSHKAQASRYFNESEALAQGISSKTMRTKIYSGVRTGQILQVPSLFDLCTRVLQKNIDALEYTGGVPFEVLRPVLERATPQQLLNFEEYNPYLMDDSDVLWQQHVQRHCRSQRREEMETWREMFLRCQEEKDRKLSILAESIKASQKISEAPVRKTQLAFVDSMVKPPRSVQRKQEQYGTKGKLIATPAARVAALSSVTPNAAKVGDARLRVLAAARDTAQVGAGPARSKKAPLMAKTLQFMRGRLKR
The following text describes a protein:
Function:
Component of the terephthalate 1,2-dioxygenase multicomponent enzyme system which catalyzes the dioxygenation of terephthalate (TER/TPA) to 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylic acid (DCD). It can also use 2,5-dicarboxypyridine (PDC) and 1,4-napthalenedicarboxylic acid (NDC) as substrates, and preferentially uses NADPH which is the physiological electron donor.
Sequence:
MQESIIQWHGATNTRVPFGIYTDTANADQEQQRIYRGEVWNYLCLESEIPGAGDFRTTFAGETPIVVVRDADQEIYAFENRCAHRGALIALEKSGRTDSFQCVYHAWSYNRQGDLTGVAFEKGVKGQGGMPASFCKEEHGPRKLRVAVFCGLVFGSFSEDVPSIEDYLGPEICERIERVLHKPVEVIGRFTQKLPNNWKLYFENVKDSYHASLLHMFFTTFELNRLSQKGGVIVDESGGHHVSYSMIDRSAKDDSYKDQAIRSDNERYRLKDPSLLEGFEEFEDGVTLQILSVFPGFVLQQIQNSIAVRQLLPKSISSSELNWTYLGYADDSTEQRKVRLKQANLIGPAGFISMEDGAVGGFVQRGIAGAANLDAVIEMGGDHEGSSEGRATETSVRGFWKAYRKHMGQEMQA
The following text describes a protein:
Function:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK-signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Syd is required for efficient kinesin-I mediated axonal transport (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MMDNDDALLNNGGPQSGAETVYGTEDNNMVMSEKNDQVVSIVQQLAGSIYQEFERMINRYDEDVVKNLMPLLVNVLECLDASYRINQEQDVELELLREDNEQLVTQYEREKSARKQSEQKLLEAEDLAEQENKELATRLESVESIVRMLELKHKNSLEHASRLEERETDLKKEYNKLHERYTELFKNHVDYMERTKMLMGSTHSQMSTASDRMEVSRARLNPVARSSGPVSYGFASLENSVMLDTETICSVGSQSDDSGPPSLQNELDMSLPSTAERGAATDSLQQQHQATSPQSPPDTSPVVPNVPPANVGRSTTKKEQRSDNNLYQELSFQDNEESEENEIVTGCWVHPGEYASSANDNYFGMGKEVENLIMENNELLATKNALNIVKDDLIVKVDELTGEVEIVREELSAMQQSRTKLRQRISELEEELKKTKEQVKQQNTEQEENDVPLAQRKRFTRVEMAMVLMERNQYKERLMELQEAVRLTEILRASRTVDNLDKKSKQSIWKYFSNLFTPSNRPTERIADGLGGGPMFRNTGGGSPAHSHGSPSRGSGDNRLTLAGSQPPMHPASAGLANALVMPKDYSEDGGSERISARRREQYRQLRAHVQKEDGRLHAYGWSLPINKANQEANPSRHSGGVPVPVYCNPLAEASPHMKVFCAAGVNLHGGFTKDGQSLIPADSPYAPKSTLKITEITSPTAEQSVEALDRQIARASLETLEPETQLSSFVWICTSTHAASTVSVVDANQSATVLDAFPICSSHLLCIASVQGAMESDYALLEQSEVVKAGEMLQRPGEGTELLGKVEFVRVKPKSEDEQNSNSKPQQQQQDEEEAKEATEKSNEPLPPVNAEEPLVNVEAIKIRQALPGAPQRLSSGNSGSDGNQANNNNSSSTGSVLFATKSLNPILGTKEREDPPMTSVGPTMWMGAQDGWLYVHSGVGRWHECLHRVLLPDAVLAIVHVEARVVVALANAQLAVFRRQTDGQWDLNSYHLVTLGDRNHSIRCLCVAGERIWAAHRNKIFIVDPISLNIVHSLDAHPRKESQVRQMAATGAGVWVSIRLDSTLRLYNTHTFEHKQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWIGTSNGVIISVPLAEVQQKTSSDPHGQMPLCCMANAQLSFHGHRDAVKFFVSVPMLQQPNLNGGLTFVNKRPDMLVMCGGEGYIDFRINDNDMENSIQLEPNQTIENRGDKSYLIVWHVSQR
The following text describes a protein:
Function:
Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane.
Sequence:
MEDIQFENEVDNKVFDIIVVGAGVAGSAFAYSLGKAGKRVLCIERDLSEPDRIVGELMQPGGVRALRELGMEDCLDGIDSSLVFGYGIFKHGKGTKLSYPKDSNGAIINGFSFHHGRFIQKLRLRASSCENVFMVEGTVNSLIEEDGIIKGVTYIESKKKDNSNENKENSDDSNNNTATTNNNNNNNKDLIKEVRAPLTVVCDGCFSNLRKSLVPENQPLLTSTFVGLVIKGVQLPFQCHGHVFLVDPAPILMYRIGSDEIRVLVDIPFKCPPNSELKEYLETVTAPQLPESLRESFLYALRNSPLKKMPNSRLPPNPTPKPGVLMIGDSWNMRHPLTGSGMTVCLSDCVILSKLITQSNPSINFTDRVSMERLIQKFTIQRKPLASTLNVLAGALYKVFSASNEHLRKACLGYLSLGGEFSAGPVALLSGLKPKPHILAMHFFAVAFYGVLKNILPFPTPARIRRCYQILCAASDIVVPLLRSEGVLKYIQNICIILRLTK
The following text describes a protein:
Function:
Required for respiratory activity and maintenance and expression of the mitochondrial genome.
Miscellaneous:
MISCELLANEOUS: Present with 1160 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MNILRIACRSFHCLRCGPLLNENRGWSSKKIIKLVNKSSLSNKEFTEKVRDGTKDIPEWKKQKMAVRKKLQGQRWNPPKKISQEQMEALRLLKFNFPELTASDLADRFKISPEAVRRILKSNWKRTDEENNNTYERWKRRGERIKEMYQRKEDADFVSNQIVTSRKIILGSNSNSPELIARNVRTFKPFKPNNSTPEKKNTNKLYILKHLGSKQ
The following text describes a protein:
Function:
Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.
Subcellular Localization:
Mitochondrion. Note=Colocalizes with MT-CO1.
Sequence:
MALDPSEQHLRHVEKDVLIPKIMREKARERCSEQVQDFTKCCKDSGVLMVVKCRKENSALKDCLTSYYKDPAFYEECKMEYLKEREEFRRTGIPTKKRLQKLPTSM
The following text describes a protein:
Function:
Chorion membrane (egg shell) protein; plays a role in protecting the egg from the environment.
Subcellular Localization:
Secreted.
Sequence:
MNKFATLAVIFCACIVGSCYANYGGQQSYGQRSYGQDSSAASAASSAAAAGAEGQQRYERPVEIIAGGYRGSYAPEILRPIQVSGGYGGERRGYNGGNYRRAGYGPRWTVQPAGATLLYPGQNNYKAYVSPPEYSKVILPIRPAAPVAKLFVPENQYGNQYVSQYSAPRSSGY
The following text describes a protein:
Function:
Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.
Subcellular Localization:
Chromosome.
Sequence:
MKVEIYEDFLISDTTNLLMSLIDFVYLNLNDNLGDPLFFQERGILAPTLDSFEHVNEYMMSLIPGEEKEYLSSYSVCRSDENSYVQSKWFTTEFLNGIKSSGILNHRLKLKMRCPVMLIRNIDKANGVCNGTRLTVTHLGKIMIAATVITGKRAGTKVFIPKMNLIPNDPGLPFKFMRRQFPLTLCFAMTINKSQCQSLSRVGVYLPKPVFTHEQLYVVVSRVTSIKEALGHGRSTSTFQSINSSFQEGKTSEATTKGNWSRYTAEESEEARQVPKSKRNRANKGTARATLKPTDQTLFETIKGNGKLIPHVVKLWVESYEKDPKSAMVELLTMLFEVCGAKFHDKRVLMHEINVNDVVVALVNYAKKSGEVECYQNSIKSEFKSLKENLESFLDNLVRECQHGPFFDKVLFEKCMKYIIALSCTPPRVYRQVASLMGLSLITSYITIANMLGVQRDITRRQLDGQKKKKTEGPRMETLNIKLSDMHEKITSLEEMMGKIFTGLFVHRYRNLDPNIRMSCIESLGVWILSYPSIFLKDVYLKYLGWTLNDKYAGVRKSSIRALQNLYEMDDNVPSLGLFTERYSGRMIDLADDIDVAVAVQAIGLVKQLIRHQLITGDELGNLYNLLTDDPPEIRHAIGALVYDYLIAKKFNSSESESRGENDNSSKVHLERMLRILDEFPPNPILTSCMIDDVWDYMEAMKDWKCIISMLLDENSLITNESKTNLVRLLCASVKKAVGEKIVPAIDNRKQYYNKSQKEVFENNKHDITIAMMESFPLLLQKFISDEAKVSLLVEIVLYMNLEFYSLKRQDQNFKNLLQLMKYAFFKHGDKDPLRGCVKAINFCCVESRGELQDVARNNLKEVEDLVIDKLESAIREVKAGGDEYSLLVNLRRLYELQLSKYVPIDKLYEDIVMVLRDVRNMKDEVVGLLLQNLYFDLAWSLKFVIDGESVSDASVKTLLSKRDTFLQELDYFVNLVTDSNEGDKSGSELDGRGYQPNADVLQKFSKLCQQQLNVSDEVEDDDVNKEETNRCAVLVGACKLIYTDVVPKDYLAPEIISHFVMHGTGVAAIVKNLITFLKKRKNDLAAIFLEALKKAYHRHTVDNSGNDDMSSENSFSECKNLAVQISRTYIGAARNKYKSDILKLVNGGIEYAFEDAPKHLSFLEAAVIHFVSKLPASDVLEIKKDVEKRTENVNKDENPSGWRPYYTFVEVLQEKGAKNEVFQVKKEGVSVKRQGRPQGKKLSYDHSSSEDEDSISTSEQEEDDEDVPLTHSIRRSSKLRPLGGKRIKIRHTGSF
The following text describes a protein:
Function:
Important for modulating JNK signaling, cytoskeletal remodeling and autophagy in larval salivary glands. During salivary gland development, involved in the positive regulation of the JNK signaling pathway, acting downstream of the TNF ligand egr and upstream of bsk.
Miscellaneous:
MISCELLANEOUS: The name 'sigmar' is an abbreviation for salivary glands marred which describes the mutant phenotype.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Note=Localizes to actin containing cellular projections and microtubules.
Sequence:
MADNVFKSHDIGLRAQKKILSRMATKNIAKTFIDGTTASLLDNLYRLCKMHTGNKAKAEKLIKNIIKIVIKIGVLHRNNQFSDEELQKAELFKRKFQNTQLSIISFYEVDFTFDLPYLQKSIAESQVALKSIVQPHLTEKSLGRIDEVFDFFGEEALLETAFRPDSPYREVMGKIVADINAAMETGDI
The following text describes a protein:
Function:
Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells.
Sequence:
MSVRVVARIRPLLKKELDKDVIVRAASTDEGKPFTIVKIPNPKNETEEFSYVFNSVYDQSCSQEDLFNAEVYPHIKALFQGLDVTIFAYGVTGTGKTHTMRGGMKMDERGLIPRLLSNVFRRGKKIEKDSNGETTVDVHLSYYEIYNDKVYDLLEPPEMRTPMGLPLREKEGKTFVVGLTERPCDDVTDFERLYVEANNNRVTAATKLNAHSSRSHAILRVKVTQTTGDMVLESTASAIDLAGSEDNRRTDNNRDRMIESAAINKSLFVLSQCIDAISRGDKRIPYRESKMTRILSLGQNNGITIMILNLAPMRSYHLDTLSSLNVSSRAKRIEVREIENEVVYKQPHRSHSSTSFSGLTNGVLAPRQPLRPIGLGTQNSYTGSAPALARSSIDRAAASGAVIEKIEKPSKLFNVYADRASAHKATASMGGGSSSRLAGPPQANTSQIRQPLSLSGGLASRRSMTDTTPASSSSTETSALRSGLIGTGASKLARPTGLPLPGSVSAGVSRQNSSSSGSIQPPQQTSKSVDNTPILTLSAAQIEAMVEKKVAEILAARAAAAAALAPQTPTPSTPRSDNHHPPGSEQQRPKSSEPRISEEVQRRLEALERRIEEQSMSTSRSSSRRGRGGRDEKSAGLQLLLEARKAKEAGQLEEALGMYEDALGFFPGQRKLVGKIEKLKLKLGKISREDYEVGAQLRDEEAGSRQGNRVGSAIQQSRSASVTSGRRTAMTGISSTDAEVEDLDDDDMEADVEETPEEAEARRRRLLKSRGRSATLGVGISSRSRQQMYSNTTTDTGSDYDDRSASNSDPEQQSSSQEPSPRTKQLLDIVNSRDTELIKSLSGFGQKRAQDLVDHLDDTQGPSGKVRSLGELTTVPGVGVRTVERAYEGLAVAAELSSKLALKTYYDETETF
The following text describes a protein:
Function:
Serine/threonine-protein kinase.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MPCTTYLPLLLLLFLLPPPSVQSKVIIKGNQTILSFKAIFRLGFFSTTNGSSNWYLGISYASMPTPTHVWVANRIRPVSDPDSSTLELTSTGYLIVSNLRDGVVWQTDNKQPGTDFRFSETGNLILINDDGSPVWQSFDNPTDTWLPGMNVTGLTAMTSWRSLFDPSPGFYSLRLSPSFNEFQLVYKGTTPYWSTGNWTGEAFVGVPEMTIPYIYRFHFVNPYTPTASFWYIVPPLDSVSEPRLTRFMVGANGQLKQYTWDPQTQSWNMFWLQPEDPCRVYNLCGQLGFCSSELLKPCACIRGFRPRNDAAWRSDDYSDGCRRENGDSGEKSDTFEAVGDLRYDGDVKMSRLQVSKSSCAKTCLGNSSCVGFYHKEKSNLCKILLESPNNLKNSKGNISKSIIILCSVVGSISVLGFTLLVPLILLKRSRKRKKTRKQDEDGFAVLNLKVFSFKELQSATNGFSDKVGHGGFGAVFKGTLPGSSTFVAVKRLERPGSGESEFRAEVCTIGNIQHVNLVRLRGFCSENLHRLLVYDYMPQGSLSSYLSRTSPKLLSWETRFRIALGTAKGIAYLHEGCRDCIIHCDIKPENILLDSDYNAKVSDFGLAKLLGRDFSRVLATMRGTWGYVAPEWISGLPITTKADVYSFGMTLLELIGGRRNVIVNSDTLGEKETEPEKWFFPPWAAREIIQGNVDSVVDSRLNGEYNTEEVTRMATVAIWCIQDNEEIRPAMGTVVKMLEGVVEVTVPPPPKLIQALVSGDSYRGVSGTSCSEGHGCSDLNTGLSSPGSRSSFGRPSP
The following text describes a protein:
Function:
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MELLTIERFLPFLEPFEGKELLTPSECSKLSLIIVEVLVDRYVDFKLLKFLSRFLTQELYDELIEERNIEHACGYIKCNRSPKSLVRRLYIKCNRSPKSLVRRLSMNSNGITQAGSESDPGASTKYQIYNRKPTMILPNTYLSQYCCKEHYQASIFYRNQLSNEALFSRKNIFTTPPFSSDKFNWYENSITCLEEVIAKHKELKQYGKSISEVIAMMNGLTVSDLNNNSELNDETNQLIKLIEDFEIVENNEPNMNGDLEEVDEEGYTQDNEENIHDITNNVEGYVTSNKSFGGYVV
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MDNGFTLNLTDSSKPTQNVPKAKPISQQEYVKDKLPLVSFASKPRQTVKSDGVKKPAFLVVRKKASLLQKKTLSEVKNFSSTNPQSISKAADQQSSHKTEPQKTTPDDAGKFGAESNFKAVKPKKATKKSSSNRKSNWAVSDQSKSSTAGYNNTGIISSLFFKNPEIPEVTKDHVEATEENVFSSQSFSALKIHKYLITTLEKDLNLKQMTEAQSRTIPILLDKKDALVKSQTGSGKTLAYAIPIVESITPKIDRTSGVFALVIVPTRELVLQTYTWFTKILKAFTWVVPGYLIGGEKKKSEKARIRKGMNILISTPGRLLDHLSSTRNLNLGRLHWLVMDEADRLLDMGYEKDVARILSIVQEHFVKEGCIGRRQNVMVSATLSKGVEKLAGLTLTDPEYIKLSEDDSENQDQLVTPTNLKQWYIIVPPKLRLATLAAFILWKCTISTEKKVLIFMTTQDSVDYHAELFNRVLAKREDRTSISFYKLHGSMPQKDRTAIFKEFRDTDSGVLLCTDVAARGLDLSAIDWIVQYNPPVTAEEYVHRVGRTARVGKCGQAIIFLAPPETDFVHRLANRGISVVEKNPDAILKTLTNSWSKTTQTMEQAATSIQLCFEECVIESYNVYEMATKGYVSFVRSYAALPKDVRDVFNFQSLHLGHYAKSFALRDPPAQINTNGRMGQRNDRIQPFNTARQRNPALLKRAAAQALGSEGTQHQPNFYERQAMLSEYSSGLDPAPAKKMKVRPTSAAALEMRNPC
The following text describes a protein:
Function:
Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors. Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2D and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors. Involved in the transport of GUCY2D and GUCY2F to their target sites in the photoreceptor outer segment. Up-regulates the activity of GUK1, a kinase that also plays an essential role for recycling GMP and indirectly, cGMP. Plays an important role for the survival of rods and cones in the retina (By similarity).
Subcellular Localization:
Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Endosome. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with GUCY2E and GUCY2F in rods and cones photoreceptors. Colocalizes with GUK1 in photoreceptor inner segments and to a lesser extent in the outer plexiform layer (By similarity). Strong dot-like perinuclear staining in the epithelial cells.
Sequence:
MSLISWLRWNEAPSRLSTRSPAEMVLETLMMELTGQMREAERQQRERSNAVRKVCTGVDYSWLASTPRSTYDLSPIERLQLEDVCVKIHPSYCGPAILRFRQLLAEQEPEVQEVSQLFRSVLQEVLERMKQEEEAHKLTRQWSLRPRGSLATFKTRARISPFASDIRTISEDVERDTPPPLRSWSMPEFRAPKAD
The following text describes a protein:
Function:
May play a role in neural crest cell migration into the third and fourth pharyngeal pouches.
Subcellular Localization:
Nucleus. Note=Predominantly nuclear.
Sequence:
MERYAGALEEVADGARQQERHYQLLSALQSLVKELPSSFQQRLSYTTLSDLALALLDGTVFEIVQGLLEIQHLTEKSLYNQRLRLQNEHRVLRQALRQKHQEAQQACRPHNLPVLQAAQQRELEAVEHRIREEQRAMDQKIVLELDRKVADQQSTLEKAGVAGFYVTTNPQELMLQMNLLELIRKLQQRGCWAGKAALGLGGPWQLPAAQCDQKGSPVPP
The following text describes a protein:
Function:
Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh) (By similarity). Inhibits bmp-signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and bmp2/4. Not involved in organizer function or early phases of dorsoventral pattern formation.
Sequence:
MLRMLKRQQLHPGMILLLFWLCYLIEDQKVQAGNCWLQQGKNGRCQVLYMPGMSREECCRSGRLGTSWTEEDVPNSTLFRWMIFNGGAPNCIPCKETCDNVDCGPGKRCKMNRRSKPRCVCAPDCSNVTWKGPVCGSDGKTYRDECALLKSKCKGHPDLEVQYQGKCKKTCRDVLCPGSSTCVVDQTNNAYCVTCNRICPEVMSPDQYLCGNDGIVYASACHLRRATCLLGRSIGVAYEGKCIKAKSCDDIHCSAGKKCLWDAKMSRGRCAVCAESCPESRSEEAVCASDNTTYPSECAMKQAACSLGVLLEVKHSGSCNCK
The following text describes a protein:
Function:
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Sequence:
MDIDPKDITISKEFQSIVVPKQLTGPVKAILQEKKLSATETKNVVDDPNGKRIILIPEVTELPKEVLEKVPEAKLEPYPVTLTYKQLTYIELLRHYIPEPLVIPTSFETIGHIAHLNLPDELLPYKKVIGECIILKNPCIKTVAIKQGPINNVYRNMELEVIAGKNDFITEVKQSGFTFKMDFSKVYWNSRLQYEHDSVVATFKENSLVCDAMCGIGPFAVRAAKKGCRVRANDLNPDSYYWLKENCKINGVSENVECFNMDAREFIRKQFDNGGCDYIVMNLPGTAVEFLDAIGEGAKKNRETARMPIVIFHSFDNKDGDYVASLRARAEKALGMKLPEMDIHNVRDVSPGKFMFRCTFSCADLFADEDDDKPHKVE
The following text describes a protein:
Function:
May be associated with hnRNA within the nucleus and remains associated during nucleocytoplasmic mRNA transport, once the proteins are in the cytoplasm, disassembly of PUB1-RNA complexes may occur prior to PAB1 binding and formation of a translationally competent RNP complex. Binds to polyadenylated RNA; prefers to bind poly(rU); binds to T-rich single-stranded DNA.
Miscellaneous:
MISCELLANEOUS: Present with 49600 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, P-body. Cytoplasm, Stress granule.
Sequence:
MSENNEEQHQQQQQQQPVAVETPSAVEAPASADPSSEQSVAVEGNSEQAEDNQGENDPSVVPANAITGGRETSDRVLYVGNLDKAITEDILKQYFQVGGPIANIKIMIDKNNKNVNYAFVEYHQSHDANIALQTLNGKQIENNIVKINWAFQSQQSSSDDTFNLFVGDLNVNVDDETLRNAFKDFPSYLSGHVMWDMQTGSSRGYGFVSFTSQDDAQNAMDSMQGQDLNGRPLRINWAAKRDNNNNNNYQQRRNYGNNNRGGFRQYNSNNNNNMNMGMNMNMNMNMNNSRGMPPSSMGMPIGAMPLPSQGQPQQSQTIGLPPQVNPQAVDHIIRSAPPRVTTAYIGNIPHFATEADLIPLFQNFGFILDFKHYPEKGCCFIKYDTHEQAAVCIVALANFPFQGRNLRTGWGKERSNFMPQQQQQGGQPLIMNDQQQPVMSEQQQQQQQQQQQQ
The following text describes a protein:
Function:
Together with SLM2, acts as an effector of the TORC2- and calcineurin-signaling pathways. Phosphorylated and activated by TORC2 under favorable growth conditions. Mediates actin polarization via inhibition of calcineurin-dependent transcription. Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin. Dephosphorylation inhibits its interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization. May play a role in the response to the disruption of sphingolipid synthesis, where dephosphorylation of SLM1 leads to the activation and phosphorylation of YPK1 through the TORC2 and PKH1 pathways, which in turn phosphorylates ORM1 and LAG1 to activate sphingolipid synthesis. Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis.
Miscellaneous:
MISCELLANEOUS: Present with 5190 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to cortical punctate structures. Correct localization requires phosphatidylinositol 4,5-bisphosphate and functional TORC2.
Sequence:
MSKNNTMTSAVSDMLSQQQLNLQHLHNLQQHTRSMTSADHANVLQQQQQQQQQQQQQQQQQQQSASFQNGSLTSDINQQSYLNGQPVPSTSNSTFQNNRTLTMNSGGLQGIISNGSPNIDSNTNVTIAVPDPNNNNGKQLQGKNSLTNTSILSRARSSLQRQRLAQQQQQQQDPRSPLVILVPTAAQPTDILAARFSAWRNVIKSVIVYLTEIASIQDEIVRQQLRLSHAVQFPFFSIENQYQPSSQEDKSVQKFFLPLGNGSIQDLPTILNQYHESLASSASKASRELTNDVIPRLEDLRRDLIVKIKEIKSLQSDFKNSCSKELQQTKQAMKQFQESLKDARYSVPKQDPFLTKLALDRQIKKQLQEENFLHEAFDNLETSGAELEKIVVMEIQNSLTIYARLLGQEAQLVFDILISKLDSGFFNVDPQFEWDNFISRDPNFLLPNLPMRTFKEIVYKYQFDPLTYEIKSGFLERRSKFLKSYSKGYYVLTPNFLHEFKTADRKKDLVPVMSLALSECTVTEHSRKNSTSSPNSTGSDAKFVLHAKQNGIIRRGHNWVFKADSYESMMSWFDNLKILTSTSNIQDKYKFITQKLNLNSDGKPKLTNNHTSINKYQLSNANSTMVENDENDDINSNYVGSTVTPKLDNQTNTNTSMSSLPDTNDSELQDQVPNIYIQTPINDFKS
The following text describes a protein:
Function:
Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan; Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
Sequence:
MPLARSLSVTSLTGLEDWDDDLDLENSILFEVAWEVANKVGGIYTVIQTKAKITTDEWGENYFLIGPYFENNVRTQVELIEPPNPAIKRALDSMNSKGCKVYFGRWLIEGSPYVILIDIAATAWNLDQWKTELWDSCAIGIPWYDREANDAVLFGFLTAWFLGEFAAQSEEKPYIIAQFHEWLSGIGLCLCRVRKLPVATIFTTHATLLGRYLCAGSVDFYNKLQSFNVDKEAGDRQIYHRYCMERAAVQCSHVFTTVSQITAIEAEHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKGRIQEFIRGHFYGHLDFNLDKSLFFFIAGRYEFSNKGADVFLEALARLNYLLRVNHSDTTIVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTIKEKFGKKLYESLLVGNLPDMNKMLDKEDFTMLKRAIFATQRHSFPPICTHNMLDDSTDAILNTIRRIGLFNSSSDRVKVIFHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVSTNLSGFGCFMEEHIADPTAYGIYILDRRFRSVDDSCTQLTSFLYSFSQQTRRQRIIQRNRTERLSDLLDWKYLGRYYMYARHMALAKAFPDNFTYEPHEPTAAQGFRYPRPASVPPSPSLSRHSSPHHSETEDDERYDEEEEAEKDRQNIKQPPVTSVGSIPEWHRRSKKGSIDATNSSNNSTPTNPSSPSDLSSPTSSLIEERN
The following text describes a protein:
Function:
Member of the two-component regulatory system TodS/TodT involved in the regulation of toluene degradation. Phosphorylated TodT activates transcription of the tod operon (todXFC1C2BADEGIH). Binds specifically to three boxes in the tod promoter region in a cooperative manner. Boxes-1 and -2 are pseudopalindromes and Box-3 is a half-palindrome.
Subcellular Localization:
Cytoplasm.
Sequence:
MPARWGCLFPGKYPCQTGLRHMSDRASVIYILDDDNAVLEALSSLVRSIGLSVECFSSASVFLNDVNRSACGCLILDVRMPEMSGLDVQRQLKELGEQIPIIFISGHGDIPMAVKAIKAGAVDFFTKPFREEELLGAIRAALKLAPQQRSNAPRVSELKENYESLSKREQQVLKFVLRGYLNKQTALELDISEATVKVHRHNIMRKMKVSSIQDLVRVTERLKDSLE