lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity (By similarity). Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 and CYP3A11 (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDEGIPHLQERQLLEHRDFIGLDYSSLYMCKPKRSLKRDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSLKSPVQADLDAFHSGFQTCAKEVLQYLARFESWTPREPRCAQLVSHLHAVATQLLTPQVTPGRGPGRAPCSAGAAAASGSERVARCVPVIQRTQPGTEPEHDTDTDSGYGGEAEQGRAAVKQEPPGDPSAAPKRLKLEARGALLGPEPALLGSLVALGGGAPFAQPAAAPFCLPFYLLSPSAAAYVQPWLDKSGLDKYLYPAAAAPFPLLYPGIPAAAAAAAAAAFPCLSSVLSPPPEKAGSAAGAPFLAHEVAPPGSLRPQHAHSRTHLPHAVNPESSQEDATQPAKDAP
The following text describes a protein:
Function:
Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
Sequence:
MKEMEQLLYSTSLRKIKVIKRDGKVDEFKLEKILSKLSSVPDEVTDGIVNDVQANVKDNAIDTRVIADIVERNLIENSLKYPFLMELAKRYVLARIYNHVFGKGKWKDFDEKDLLLSYNALKVLEARYLLKDPNTLRYIETPQMLFRRVARFLASVERKYGKSEAEVKQLEDKFYEMISDLKFVPNSPTLMNSETRLGILSACFVIPVKDAMTTPEGDGIYDALRATALVHQQGGGTGFDFSELRPKGDVVASTAGVASGPVSFMKVFDASTDVIKQGGKRRGANMGVMHAWHADIEDFIRAKTGQLKDVQLQNFNISVGAYDYFMDAVVKGESVPLINPRKTKIAGRDHEYYITKARGYMSEEWIQEVILSELEEKGGVVSLDESKIITVDEALVIASKEGAVVKYVNAKSLFDEIVKGAWDSGDPGLLFIDTINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVIERDGKAAIDWDGLAEIIRYGVRFLDNVIDANRYPLKQIEDATKRTRKVGLGVMGLARMFIKLGIAYDSVDAIYLSYQLAKFIFYHAYKASIEIAKEKGTFPTYDARLYRDIWESALDFDSLLQTAEISDKPSDYVKKLTSVVDKLDFDLLKGERLKYGLRNSTVVSIAPTGTISIIAGTSSSIEPLFALAFVRNVAVGKFIEIDPLFLEYLRKYELDDPEVIQKIAESGIIGDNVFMPRSLRKLFRTAHEVPPIYHVMHQAAWQQWNDSGTSKTINLRSEEPPETVEKVYLLAWKLGIKGITVYRDKSKQQQVIYFGVKKEREEYEKKKEEVEKKTQLLPSSLRMEKKFVEVSETYAGGCKTCEL
The following text describes a protein:
Function:
Component of the viral DNA-dependent RNA polymerase which is composed of four equimolar subunits of LEF-4, LEF-8, LEF-9, and p47. Plays an essential role in late and very late gene expression.
Sequence:
MVRKIYFLTLLYFALCVNTRSCTDVIMFSFLDKTPTEFDLILDPHKLQNVAFFTNEEFKVILKNFITDLKKNQKLNYFNSLIDQLINVYTDASVKNTQPDVLAKIIKSTCVIVTDLPSNVFLKKLKTNKFTDTINYLILPHFILWDHNFVIFLNKAFNSKHENDLVDISGALQKIKLTHGVIKDQLQSKNGYAVQYLYATFLNTASFYANVQCLNGVNEIMPPRSSVKRYYGRDVDNVRAWTTRHPNISQLSTQVSDVHINESSTDWNVKVGLGIFPGANTDCDGDKKIITFLPKPNSLIDSECLLYGDPRFNFICFDKNRLSFVSQQIYYLYKNIDAMEALFKSTPLVYALWQKHKHEQFAQRLEMLLRDFCLIASSNASYLLFKQLTQLIANEEMVCGDEEIFNLGGQFVDMIKSGAKGSQNLIKSTQQYRQTLNTDIETVSSRATTSLNSYISSHNKVKVCGADIYHNTVVLQSVFIKNNYVCYKNDERTIMNICALPSEFLFPEHLLDMFIE
The following text describes a protein:
Function:
Integral membrane transporter that imports quinic acid to be catabolized as a carbon source.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSAGSFAGAIAAGFISDRIGRRLSLLVASLVWITGAVIQCSAQNVAHLVAGRVISGLSVGITSSQVCVYLAELAPARIRGRIVGIQQWAIEWGILIMYLVSYGCSEGVHSPAAFRIAWGVQAVPGLILAVALLFFPESPRWLASKERWEESLDTLALLHGHGDRNHPEVQVEWEEVQEAVRIAREAKDVSLFSLLGPRVWKRTMCGVSVQVWQQLLGGNVAMYYVVYIFQMANMPGDTVLYSSAIQYVIFLVTTGVILPYIDRIGRRLLLLSGSIICMALHYAIAGIMATYGNPVDEIDGNKNLRWEIKGAPGKGVIACSYIFVGIYGLTWAPAAWIYASEVFPLKYRAKGVGLSAAGNWIFNFALAYFVAPAFTNIKWKTYIIFGVFCTVMTFHVFFMYPETARRSLEEIDMMFDSKVKAWQSHKVHDKFGEEIEKHRQQSVVEAEKPVESVHAEVV
The following text describes a protein:
Function:
Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Sequence:
MIVEVFFRNFYRNFAKFEIDAVDKREFAFQPFSGGMVRHKSFKSLEDLRKFVVEKTPRHIYHSAAYYERPGEEDMERKGWIGADLIFDIDGDHLDTEACRESKIVSLRCLEDAREEANKLIDVLIQELDLKPTRIVFSGNRGFHIHVSSEEVMKLGSRERRELVNYLKAVGFDPSRFIAKLGRRKVVLYEEEAVGNLLRIKQGVEDARAMKVEIDEVVTQDIHRLIRAPGSLNGKTGLVALPISLKELDKGVEYIVDKAIAFRKGHLKFKFEKPVEGPVLFEKVGGREGDVKVLPAYVAIYLELQEFGKIYD
The following text describes a protein:
Function:
Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
Sequence:
MGQKVHPHGIRLGIVKPWSSTWFANTQDFADNLEGDFKVRKFLNKELASASVSRITIERPAKSIRVTIHTARPGIVIGKKGEDVEKLRNAVSKIAGVPAQINIAEVKKPELDAKLVADSIASQLERRVMFRRAMKRAVQSAMRLGAKGIKVEVSGRLGGAEIARSEWYREGRVPLHTLRADIDYNTAEAHTTYGVIGVKVWIFKGEILGGMAAVAQSEQQPADKPKKAPRGKGRK
The following text describes a protein:
Function:
This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively.
Subcellular Localization:
Secreted.
Sequence:
MAYLLHAQLFLLTTFILVLNMRLCPVLGHFLGGIEKSSMEEEGASEALNYAVNEYNEKNSDLYLSRVVEVKDVQKQVVAGTKFFFDVILGKTICLKTQGDLTNCPLNEEADQQEHEFCSFVVHDIPWENYIVLLSSSCHSI
The following text describes a protein:
Function:
Multidrug efflux pump.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKINRENIKTVLSLALPAVGEMILYMMIWVLDTMMVGQYGGQIAVSTVGLSSEIIYTFTNIFIAVGLSIGITSIVARSYGSDNLHLAEEYASIGLSIGILIAFFISIILFIFPKTILSLANAKEAVLINGTIYMKIISLGIFFSMLTSLMNSIVRGYGNTKTPLFISILINIVNLTLDYGLIFGKLGFPELGIRGAAIATSIANLSGFMFAIYYLFTKSKIKPKIKYIKNINISRFKYLIRLSIPSSLQEASLSVSKLINTFMIMHLGTVAFASNQIALTVESISFMPGWGFAVAATTLTGHKIGEKNIEKARDYSHTCTFLGICIMGITGLIFLIFPSFIIKLFITNSEKQVITLGSRCLMIASLEQIPMAISMILGGSLKGFGDTKTPFLVSFISSWLLRLPLMFYFIYIVKSSVTYVWWITSIQWIFEAICLIILSRKKFNK
The following text describes a protein:
Function:
Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.
Sequence:
MNSTSLYAAIDLGSNSFHMLVVREAAGSIQTLTRIKRKVRLAAGLNNDNHLSAEAMERGWQCLRLFAERLQDIPQPQIRVVATATLRLAVNAGEFIAKAQTILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFSDRNLAQENFDDAEKAARDVLRPVADELRFHGWKVCVGASGTVQALQEIMMAQGMDERITLAKLQQLKQRAIQCGRLEELEIEGLTLERALVFPSGLAILIAIFTELNIQSMTLAGGALREGLVYGMLHLAVDQDIRSRTLRNIQRRFIVDTDQANRVAKLADNFLKQVENAWHIEPISRELLLSACQLHEIGLSVDFKQAPYHAAYLVRHLDLPGYTPAQKKLLATLLLNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAILFAGRRRDDLVPEITLQALNENLTLTLPGDWLAHHPLGKELIDQESQWQSYVHWPLDVR
The following text describes a protein:
Function:
Functions in planar polarity establishment and circadian rhythms by promoting the activity and localization of dco/dbt. Required for regulating the levels of dco/dbt and per in the nuclei of photoreceptor cells and thereby is involved in normal oscillations of the circadian clock proteins in the eye. In the dark, the cry circadian and rhodopsin visual pathways, activate the accumulation of the protein into Arr1- and Arr2-dependent cytosolic foci which are required for dco localization to photoreceptor nuclei. It is possible that the accumulation into foci results in the dissociation of the protein from dco, thus allowing dco to interact with importins and microtubles for nuclear transport. By promoting nuclei localization and kinase activity of dco towards per, it is essential for regulating normal cycles of per nuclear accumulation in brain circadian neurons and thus is important for normal circadian behavior. Essential for regulating the establishment of planar cell polarity in the wing. Forms a complex with Ankrd49 which likely functions in the regulation of planar polarity by promoting the activity of dco during planar polarity establishment. Within the complex, directly promotes dco activity in regulating phosphorylation and asymmetric localization of core planar polarity proteins such as dsh.
Subcellular Localization:
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=During the dark period, forms discrete cytosolic foci in photoreceptor cells. During the day (ZT1 and ZT7), detection is limited to the outer part of the retina and does not occur in all photoreceptors. At early night (ZT13), the foci increase in number and are broadly localized in the retina, and by ZT19 most photoreceptors express high levels of the foci in both the inner and outer parts of the retina. Under conditions of constant darkness, foci accumulation is high and broad in photoreceptor cells. Under conditions of constant light, foci accumulation is low and are restricted to 'finger-like' projections in the retina, appearing to be mostly localized to the Rh3 cell cytosol adjacent to the rhabdomeres.
Sequence:
MDWYVGTEWEDKNRGLAKKVIGLQFTEMDKPTIISTVEFSVNKKATNLGGRPSKYLVSDESATYPQKHSLEMGTSLTAVDCYLELLLQQFVPGETAACSITTKTGERIEFELKLEKIVKNTQVEKLSAAEIYEVALRLKESGVATFKTFPKFAFDYFVRAAKLLITYKPFDKLTKKTNGINGQAVEELFIQIQTNLAACLLQEKRYEHVIYHTQFVETEESPSEKSIYRRALAYYHLKEFAKAQATIERMPNYEEKREFSKLRDNIAVSWKDSKAHYKEVVQRMFS
The following text describes a protein:
Function:
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MGRIAKEVAGQTLCFIGFVGICICCGIPMWRVTTYIGANIVTGQIVWDGLWMNCVMQSTGQMQCKIQDSIMNLTQDLQVARALVIISILIGFMGMLLTFIGGQCSSCLKNESSMAKVLILGGILCIVAGVLLLIPVCWSAAYTISDYVSVTTIQTQKRELGASIYVGWGASAFLLFGGIILCTSCPPRENIYPQYPGMYPYQGPVYGHQYAPSTVYKPYHPPVAYTPAPRQYL
The following text describes a protein:
Function:
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
Subcellular Localization:
Nucleus.
Domain:
The N-terminal half of the protein contains two conserved domains I and II. Domain I includes a slightly degenerated ERF-associated amphiphilic repression (EAR) motif which seems to be involved in the activity of transcriptional repression. Domain II is required for the correct degradation of the protein through the SCF-mediated ubiquitin-proteasome pathway. Interactions between Aux/IAA proteins and auxin response factors (ARFs) occur through their C-terminal dimerization domains III and IV.
Sequence:
MEKVDVYDELVNLKATELRLGLPGTEETVSCGKSNKRVLPEATEKEIESTGKTETASPPKAQIVGWPPVRSYRKNNVQTKKSESEGQGNYVKVSMDGAPYLRKIDLTMYKQYPELMKSLENMFKFSVGEYFEREGYKGSDFVPTYEDKDGDWMLVGDVPWEMFVSSCKRLRIMKGSEVKGLGCGGL
The following text describes a protein:
Function:
Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.
Subcellular Localization:
Mitochondrion.
Sequence:
MSACVNFVRSSFLRPACPSSLAVRSATVFRQVLSSDGLQSSQHHCSTLRPTAATAVRSLATQTPDHGVPDTEDNDIINPNFINRNPRNLERMGLGRKERGWKTTWPKKECWHRCHFVKSKRYVTGYVQHHNGHIVASASSFEWPIRKHLYSTSDVSAAENIGHVLAQRCLEAGIHFMEFDDVPHKLESETVQRFQQAMVDGGINLSEPRRIYEHKHLFKETDYDAEDYNMKEAEIEQ
The following text describes a protein:
Function:
Involved in DNA recombination.
Sequence:
MLLRRSSTTGLEQALRAEQRDGRGELREQLEGLARQQDGRLETFARNLTELSTRTDQRLDLLRDALGEDARKAREESTQAQLRTGELLTGRLTELRTQLDGFGQQQEARIHVFGQQLTELIARTDTHMAALREALAEDARKGRAEAGESQQRFTEALGQRLTELTQRNELRIGEMRATLEQQLASLQSDNASKLELMRATVDEKLQTTLNTRLDASFKLVSERLEQVQRGLGEMQQLATGVGDLKRVLTNVKDRGGWGEVQLENILEQTLTMEQYARSVRVKPDSAEAVDFAIRLPGRGDDTVVWLPVDAKFPREDYERLIDAQEKGDLDAIKSSTAQLERAIRIQAKSISDKYVCPPHTTDFAVMFLPTEGLYAEVIRRAGLVDLLQREHRVVLAGPTTFTALLNSLQMGFRTLAIEKRSSEVWQVLGAVKSEFGKFAGILEKAERQITTVGKSLGEASRKTRTIERRLRGVETLAGEQSQALLDDAGNDDTGSSDDEAGDEQE
The following text describes a protein:
Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MPGAARVLLVLLLSGGFGGGRTQRPQQQQELRRQPPAHQQRGLFPAVLNLASNALITTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPYQRHPITNAIDGKNTWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVDYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSADDPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSIKDISVGGMCICYGHARACPLDPVTNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTRNTDGINCETCIDGFFRPKGVSPNHPRPCQPCHCDPVGSLNEVCVKDEKRARRGLAPGSCHCKPGFKGVSCDRCARGYTGYPDCRPCNCSGAGSTNEDPCFGPCKCKENVEGGDCSRCKSGFFNLQEDNHKGCDECFCSGVSNRCQSSYWTYGNIQDMSGWYLTDISGHIQVAPQQDDMDPPRQISISSSEARRALPQSYFWSAPAPYLGNKLTAAGGELTFTVSYDLEEEEDDDTERILQLMIILEGNNLRISTAQDEVYLKPSKEHINVLTLKEELFTIHGTNFPVSRKEFMTVLANLKRVLIQITYSLGMDAIFRLSSVGLESAGPYPTDRSFAAAVEVCQCPPGYTGSSCERRHPANASSNLIPANNAKACWPRHRRVNGTIFGGICEPCQCFGHAESCDDITGECLNCKDHTGGPYCNKCLPGFYGDPTKGTSDDCQPCACPLNIPSNNFSPTCHLDRSLGLICDKCPVGYIGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCHCNANGSFSDVCHTRTGQCECKPNVQGRRCDECKPAMWWDPEKRLCVSCGCNPVGSMTPQCDISGRCVCKSSFVGKRCNLSRQVHRQEKQPQRAQRVLGSPQRWGVSSSSGCPRGAYRPLAPPETFGLQSARGCIPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACDCSHLGNNCDPKTGQCICPPNTIGEKCSKCAPNTWGHSIITGCKACNCSSIGSLDFQCNVNTGQCNCRPKFSGAKCTECNRGHWNYPHCSPCDCFLPGTDDSSCDLETKKCSCIDQTGQCTCKVNVEGVHCDRCRPGKFGLDAKNPLGCSSCYCFGVTTQCSEAKGLIRTWVTLQPEQTILPLVDEALQHTTTKGIAFQHPEIIAHMELVRQDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFEAREETGFSTYNPQVIIRGGTPTHARIIIRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPRVSRTVTREDFLDILYDIHYILIKATYGNIMRQSRISEISMEVAEQGRITAVTPPAHLIERCDCPPGYSGLSCEACMPGFYRLRSKPGGLTPGPTLGTCVPCQCHGHSSLCDPETSICQNCQHHTAGDFCEQCAPGYYGIVKGLPDDCQQCACPLISSSNNFSPSCVLEGLDDHRCTACPRGYEGQYCERCAPGYAGSPSSPGGSCQECECDPHGSLPVPCDPVTGICRCRPGATGPKCDGCKHWHAREGMECVFCGDECTGLLLGDLARLEQMAMSINLTGPLPAPYKILYGLENMTQELKHLLSPQRAPERLIQLAEGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNTRANSLGEFIKDLARDAEAVNEKAVKLNETLGTQEKAFERNLQDLQNEIDQMMTALRRRNLDTQKEVAEDELVAAEGLLKKVKKLFGESRGKNEAMEKDLQEKLADYQNKVDDAWDLLREATDKIREANLLSAENQKNMTALEKKKEAIESGKRQTENTLKEGNDILEEANRLADEINSVIDYVQDIQTKLPTMSEDLQDKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILEEAKNISFNATAAFKAYSNIKDYIDEAEKIAKEAKVLAHEATELVRNK
The following text describes a protein:
Function:
Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and may act by promoting the disassembly of the MCM complex from chromatin (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTDNNNLDSLIIDKDEYLNSPMNVVDKLFKFDQNNLNNGTVYKKFENVISEDQIYKSIPLVSTINQCDLNSGKLVKIRCMIQDIFDPQFCPSFNKIKNIETNEIRLEASKYKDKINLNDCEELIFDSFDSSTFDKTILYCIPIPCENKWVNNNNNNNNNNNNNNNNNNNNNNNNGNEQISSSLLNKKKRNIDDADMKNENDEENKKSKDQKSTTTTTTTTSKEGEEEGEEGEQLTKSKKLLTNNKIDINKIFNYPIPIDSNDENNLKTPFIVNIYDDDIIFDENNKAVTFKINEIIEFVGVVAKFNPTLQHQSSNSSDQGETTTTIIDLMSMLDVDEISTIPDTLIPQFHAITYRYLDPYKFNHLNPFSIDTNTTINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNPNNNNPNNNNLNNNLIRNELIKFIKLFIVDELLSEYLLFHLISKVYSFTSGLSIGNFSMNISIPNDKEFQRLPQLIELLYEILLARSYRFSMSLENLNDMDVVPYKDYDRNRIVSGLLQLPKGTNLILDETQLTEGKVESQGIKVLNALNTLSIQQKVEYDFKYHPIEIQTDLPTISISFGKSLIKGTTQISINKSIQLPTINEINQQLIHSYNNDKLNQFRNYINHCKNLSFKISSPTTTTIAESDDATRHIQEDFVKSRQLDSKMTTDVFHYWLTLSRLVALSFNDQYIKIDKWNIMKSLEEKRKLTINNL
The following text describes a protein:
Function:
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Subcellular Localization:
Cytoplasm.
Sequence:
MKLFDYAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKIPKTIFPKSSNLFYALNLTPPCAVKIILLGQDPYHSTYLENDQELPVAMGLSFSVEKNAPIPPSLKNIFKELHANLGVPVPCCGDLSAWAKRGMLLLNAILSVEKNQAASHQYIGWEAFSDQILMRLFETTAPLIVVLLGKVAQKKIALIPKNKHIIITAPHPSPLSRGFLGSGVFTSVQKAYREVYRKDFDFSL
The following text describes a protein:
Function:
Pectinesterase which probably plays an important role in the digestion of plant cell walls.
Miscellaneous:
MISCELLANEOUS: May originate from horizontal gene transfer of a bacterial enzyme to an ancentral weevil genome.
Subcellular Localization:
Secreted.
Sequence:
MKIIVLLLLAVVLASADQTAPGTASRPILTASESNYFTTATYLQGWSPPSISTSKADYTVGNGYNTIQAAVNAAINTGGTTRKYIKINAGTYQEVVYIPNTKVPLTIYGGGSSPSDTLITLNMPAQTTPSAYKSLVGSLFNSADPAYSMYNSCASKSGTIGTSCSTVFWVKAPAVQIVNLSIENSAKNTGDQQAVALQTNSDQIQIHNARLLGHQDTLYAGSGSSSVERSYYTNTYIEGDIDFVFGGGSAIFESCTFYVKADRRSDTAVVFAPDTDPHKMYGYFVYKSTITGDSAWSSSKKAYLGRAWDSGVSSSSAYVPGTSPNGQLIIKESTIDGIINTSGPWTTATSGRTYSGNNANSRDLNNDNYNRFWEYNNSGNGA
The following text describes a protein:
Function:
Required for specifying floral primordia and establishing early internode patterning events during inflorescence development.
Subcellular Localization:
Nucleus.
Domain:
The SR/KY and BELL domains are responsive for the interaction between the TALE/BELL proteins and the TALE/KNOX proteins.
Sequence:
MDMIKPDFQQIRRDKFRVEQMNDFPNTWTQQQHQNIRIPNNLDLIGILQNQISVPVQTDLYQDSAATFMNMPQSIHRDPQGPSNWRISDLSQPSTVNHGYDQAGIRPNNVADLLSDHFSSRNQILDRPLYVGRDSIPQSSMIRRSEVSCLDDNQKGCVTVACSGTGNEILRSSYDQGSSSGSYRGEFSFLPSLENQSVAHNASNWNHGPVNVTATSHTNSKKGFPLSLLSDIPPSRDVGNAAVLSTMNIHGPLGPFTGYASILKSSRFLEPAQKMLEEFCISYASKIISRSESTSMEDDDDDDDNLSGFSSSSEPLEPKNRLKKAKLLFLQEEVCKWYKLYNHQLQTVMSSFNTVAGLNTATPYISLALKRTSRSFKALRTAIAEHVKQISSHSSNGNNNNRFQKRQRSLIGNNVGFESQQQHIWRPQRGLPERAVAVLRAWLFDHFLHPYPTDSDKQMLATQTGLSRNQVSNWFINARVRLWKPMVEEIHTLETKAIKNADTSHNIEPSNRPNTVSSPSHEQTLTGLSGTKRSRLEYMDMVGFNRGNVSLTLELRRGVDNVIQTQTQDHQFGTGSQMFHDFVG
The following text describes a protein:
Function:
Ca(+)/H(+) antiporter that extrudes calcium in exchange for external protons.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein.
Sequence:
MRRGDIGSCDRVDPSGKTLAGCDAGGDRGLGHGAFSSRAMWASDRTAARLLRPTLRQINTRLAGPPDPSISASMERAADMQTLLREIRNTPLLWMLVFVPIVLLAEAAAPHSHTLLFVLAVLAIVPLAALLSHATEAVAAKTGDAVGGLLNATLGNLTELIIAITALRAGQYMLVKASIAGAIVTNAVFMLGACLLLGGLRYHVQEYNRAGARLSSGLLLMATVALLAPSAVADLEHLPQGGGILNKLSVGISVLLIIAYALGLLFSLGTHKELFASADHGDDKEAHWPIGIAVGTLLVVTVLVALVSEIFVESVQKAAETFGMSPAFVGFIIVSLVGAAAEFAVAFGAARKDRLDMVVSIALGSASQIALFVAPALVLLSYVVGPTPMNLQFWPGAVTMVMIATVTSAFITASGRSAWFVGALMIFIYAVFALTLYVVPPAGEG
The following text describes a protein:
Function:
Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
Subcellular Localization:
Cytoplasm.
Sequence:
MVKIFVPAAVKLFGEHAVVYGKPAISAAINKGVYVECEKSDKLSIETAGYPSALRFYPGEGRVEAVGAERFFAYINAALRLAEEKWGGLAARFYIKSELPPGAGAATSAAVSIGLLKAYALCAGGDVEGIELAKMGHRVELEVQGIASPMDSTTVTLGGVLKIKTNPFSVDKLNANLPPFYIAFLPRFETTGEIVRGVKALLERRRSAAFVIEAIGRVVEEAEQCLLNRDLECVGELMGINNWLLGALGVVDERAINLLNAARPFIYGGKISGAGRGGAVILLPRSEDALERVLSASGYVYHKVTIYEGGVTVL
The following text describes a protein:
Function:
Necessary for formate dehydrogenase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MSHTAEIPMVPGSESPLELKPLKAVDPKAVYHRRAQRLLSLAKDSPLADYFELCRRVVAIQARLAAEADFGQLLAWGKDEAIPLSHLGSEADSYWQGLLQQLLSDLLPQVGEDLARVLRLLMQQSPEQLTSWGASLRQGHMSAVPARFSLFIWAAMGVYWSHWAPMVIKRIDQRKVAQQNLCPICGSHPVASVIVDQPRAGLRYLHCSLCESEWHYIRAHCTSCGQDKGTTLWSFDDTQAQVRIESCDECHGYTKMMFVEKSPLMDVVADDLATLMLDSELNAKGFGATTVNPLLLAHETEQ
The following text describes a protein:
Function:
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus, Golgi stack. Cell surface.
Sequence:
MKCSCWALVLAVLGAELLGSLGSTVRSPRFRGRIPQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFTNAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPIMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNVLHRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDPPPDVDGKSVLKLLDLEKPGNRFRTNKKAKIWRDTFLVERGKFLRKKEESNKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTAGKLRIHKCKGAGDLLAARQSTRNVYPRGFHDKDKECHCGEAAYRAGRSQRKGQRQFLRNQGAPKYKPRFVHTRQTRSLSVEFEGEVYDINLEEEELQVLQPRSIAKRHDEGHKGPGGRQAANGGNGDAMLATSGNAVGLPTTVRVTHKCFILPNDTIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNLREVRGHLKRRKPEECVCSKQSYYNKEKGVKKQEKLKSHLHPFKNREAAQEVDSKLQLFKENRRRRKERKEKKRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLRTVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHIQLMELRSCQGYKQCNPRPKGLDVGNKDGGSYDLHRYSPFFILPG
The following text describes a protein:
Function:
Prenyl transferase; part of the gene cluster that mediates the biosynthesis of paxalline, a mycotoxin that acts as an inhibitor of mammalian maxi-K channels. PaxG, the geranylgeranyl diphosphate (GGPP) synthase is proposed to catalyze the first step in paxilline biosynthesis. Condensation of indole-3-glycerol phosphate with GGPP by paxC then forms 3-geranylgeranylindole (3-GGI), followed by epoxidation and cyclization of this intermediate (by paxM and paxB) to form paspaline. Paspaline is subsequently converted to 13-desoxypaxilline by paxP, the latter being then converted to paxilline by paxQ. Finally paxilline can be mono- and di-prenylated by paxD.
Sequence:
MGVAGSGVLYFLFNNVPSPRFWLKKTQLIGTENPEGITGYECPYEYLRKSYGKHHWAAFVDKLSPNLQNEDPAKYRMVLETMDVIHLCLMMVDDISDGSEYRKGKPAAHKIYGAPETANRAYYRVTQILAQTATEFPRLSPWLMTDLRDILEGQDMSLVWRRDGVNGFPGTASERTAAYKRMVLLKTGGLFRLLGHLTLENNSMDEAFSTLGWHSQLQNDCKNVYSSEYAKMKGVVAEDLLNREMTYPIVLALDASGGHWVEAALKSPSRRNVGNALKIIQCDYVRDVCMAELARSGAPVKEWLKLWKREEKLDLKA
The following text describes a protein:
Function:
May be a regulator of keratinocyte proliferation or differentiation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MERKNIVKEKLIVPTDFISPAHLTNVQGDLMPPSHFESGVQSSGAHRGVLVGPKTSPQTTWRNPVPISGPRDPSLAGPCFTFPQREDNREMILLQGDFLRANEAGGQPAAHRFGEKGEQQYTWESQHQLGMEKHKAEAERLKGQVEALKEAAEKYREEMKDREITLCRCTHELEVARENASKAKAELSQVREELSLSRGQEEMMRLRLEKVKAECGEEIAQLRRSLVKSKQESRELALKVEMSRLQAEEEAKEQALRLSKQLEKMKEMQEAQLQHLNASHYTELDTARQANSELQDRLQSMSTKVLQLQSALMEASAERDELKEHLSHVGRAFETQSATLQSLRNYIGQLTPERGEKEQLKETIEKLNKEKAALQTTTELLTVRLNSVNEILTLQEEKLVKKQTSADPLQWKEPDILQVLQLWREKVFKLCVQLRSKDIETRREKDKVLFDVRSTEQQLQQEQHQNRLLQHSLQDRMAELDLEKVEKETLREDLTKVERENAELKSQNQRAEAEIKILIEAVQRFQKEFDRKTAEVDSAKTKLNTFTQRLSFASRRVETIQCLVMRRAALQKIEQACQPPKQEKNSLTNLQTEYGLICEERDRLSLELKRTPELIEKALADLKEQYGSKVRQLEQELELSCMEVKQALAGKEKAEQRLQQIQAQLDETSISLETLPCELLHQQERNQQALQERVSAIEAAHAEKTKELELQLHAARREHTRAVMTLLQFQRQAARQHDEITETPNWGGENTKQNVLNKHVKEMEGSKKFLHVMASKEAPMAEHAQSRETPSEKRTSVEAEVHLPAERLLSVLEELHTLSAAVVNSSEDSSEEELRSDDRKTSADLLDSQDMKN
The following text describes a protein:
Function:
Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP.
Sequence:
MSFQKELEVAISAVRRASFLTEKVFNELVQLRQKHQSGAIIKSDQSPVTVGDFGAQAVIAALLHDAFPQDPIVGEESADFLRSNDEVCNQVWSLVQESTKRASEFPELGRIASKEDMCNAIDRGSYVGGPTGRMWSIDPIDGTKGFLRGDQYAICLSLIQDGVPVVGAIGCPNLYWDVPATADGRRGLVMAAVRSRGCYQYELHKDGYEGERVQMRPVTRSSDAKFCEGVEPGHSMQDTQEQIARELGITLEATRMDSQAKYASLARGDGDIYLRLPRSMKFEEKIWDHAGGSLLVQEAGGIVGDMFGKPLDFGRGRTLNHNHGVIAAAKGIYEQVIAATKKVTGNDPQFAL