lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a glucosidase that shows high activity toward sucrose, a major component of nectar. Assists the mosquito in its sugar-feeding capabilities.
Subcellular Localization:
Secreted.
Sequence:
MPPLGVLLLLVALGHSTQGHRPLPIRKAHKFDWWERGNFYQIYPRSFKDSDGDGIGDLKGITQTIDYLKTIGIDGVWLSPIFKSPMNDFGYDISDFYAIQEEYGTMEDFEELAAKCASIGLKLILDFVPNHSSDEHEHFRLSEEGIEPYKDYYIWHSGVLDANGTRHPPSNWISVFRGSAWQWSDKRQQYYLHQFQKKQPDLNYRNPALVEEMKNVMRFWLNKGIAGFRIDALPYLFESEEVDGHYRDEPLSGQATDDPDNPAYLTHTETKDQPETYDMVHQWRQVVDEYTARDNFTRIILTEAYTAVQNMTRFYGTPAAPGAQIPFNFQLITLLTVNSTGRDFVNAVQSWTRAMPSGAIANWVLGNHDNSRIASRLGVARADLYNIALQTLPGIAVTYYGEEIAMVDQWISWNDTIDPAACNADPATYELYSRDPVRTPFQWSNGTNAGFSNASRTWLPVADGYRELNVAAQLAAPRSHLKTFMQLTAYRKRRLLAEGNFVLRTVGRDLVMYKRSVPGVGYVVVALNFGPEPATLPVASQFPGTGEHWLKVIASSLQAQPQAGTWINTRLYKLAPDSGIVLERLTGRNDLMT
The following text describes a protein:
Function:
Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR. Links the two-component systems CpxA/CpxR and EnvZ/OmpR.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Domain:
Interacts with EnvZ through its soluble periplasmic region.
Sequence:
MQIPRMSLRQLAWSGAVLLLVGTLLLAWSAVRQQESTLAIRAVHQGTTMPDGFSIWHHLDAHGIPFKSITPKNDTLLITFDSSDQSAAAKAVLDRTLPHGYIIAQQDNNSQAMQWLTRLRDNSHRFG
The following text describes a protein:
Function:
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits cdk1 and acts as a key regulator of meiosis. Required to maintain meiotic arrest in oocytes by phosphorylating cdk1 at 'Tyr-15', leading to inhibit cdk1 activity and prevent meiotic reentry (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MKWSEMASVNATQQHLNFSSSWEEDSSDNSFDEWTHKSVPLRSPCRTPRIQRHRNRSITVSPSVPTSPIPYAAWKKLRLCDSPSTPKSLLSKSTMPCSSSKTCRSQRFLRLSTAFERVPSVNINPFTPDTVRRNSEHYKRKSQRSDDDEDYGPRSKEIQNSSEDESFFLPSKRPAVSARMLSRYESEFLELACIGVGEFGSVYRCVKRLDGCMYAIKRSRRPIAGSANEQLALKEVYAHAVLGHHPHVVRYYSAWAEDDHMIIQNEYCDGGSLHDAITEKREQGEFFSVPELRDLLLQVSMGLKYIHNSGLVHLDIKPSNIFICRRSTLSAGGEGDSEEEDESHSSGVVYKIGDLGHVTSISSPQVEEGDSRFLAYEVLREDYTHLPKADIFALGLTVLLAAGASPLPQNGDDWHRLRQGELPNLPHELPALFKDLLKSLLDPDPTARPSATALCRHDVLCKERAGKLATQLRKELNVEKFRTAMLERELKEARLAATSPQQSCQPGSLPKAKRKLVGRNVARSVSFGFPGY
The following text describes a protein:
Function:
Palmitoyltransferase that targets several endosomal SNAREs. Palmitoylates the SNAREs at cysteine residues close to the cytoplasmic end of their transmembrane domain. May have a role in the cellular quality control of transmembrane domain-containing proteins (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MMGALCALAVTQAGLILAAPALRAYWPFSWYYHVVFRTVLQDTQRHRWKYWATPAFYAGVYAYCVWLFYGEVYAEIAKALWVPERWVLPAAVVAPAAAGVAAAATPAAVPADAAYDGLLFHDGVECRTCRVRKPARSRHCGVCGRCVPLADHHCVWLNNCVGRGNYGLFYLALGAHCALLTYGAVRLPLAAPAGRWPRALLALELLVASFAVLCVWFTATQVALVRDGMTTNEQDKWYAVQESMREGTLVRLRGRFYHRVEGGDGVEFYSTNAYDHRTYALHNEPYAVVTSHEEIPNVYDTGSFCENLRQRLDPQARIFRRRVRGL
The following text describes a protein:
Function:
Transcriptional regulator of the bhc gene cluster involved in glycolate and glyoxylate assimilation via the beta-hydroxyaspartate cycle (BHAC). Glyoxylate negatively affects the interaction of BhcR with the promoter region of the bhc gene cluster.
Miscellaneous:
MISCELLANEOUS: The beta-hydroxyaspartate cycle (BHAC) consists of BhcA, BhcB, BhcC, and BhcD enzyme activities. Overall, it converts two molecules of glyoxylate (C2) into oxaloacetate (C4) without the loss of carbon as CO2, under consumption of just one reducing equivalent and regeneration of the catalytic amino donor, which makes it one of the most efficient glyoxylate assimilation pathways. This cycle is of ecological importance in the assimilation of phytoplankton-derived dissolved organic carbon in marine environments by marine Proteobacteria, and suggests a trophic interaction between autotrophic phytoplankton and heterotrophic bacterioplankton. Oxaloacetate formed in the BHAC can directly enter the tricarboxylic acid cycle or serve as substrate for anabolic reactions.
Sequence:
MSVQIRKRGRPRGRAGGLGAEDSGGIRALDRALDILDLIAVSSGLTLTEIAQRLDMAPSTVHRVLVTLAARGVAESDSQTQAWHVGPTAFRHGSAFMRRSGLVERARPLLRRLMEVTGETANLGILNGDAVLFLSQAETHETIRAFFPPGTRSALHASGIGKALLAHARPLDLKRMLREMRLERFTDMTLTDPAALVEDLVQIRARGYALDNEERTPGMRCIAAPIFDLAGEAAAGISVSGPTLRMSDARLSAMSDAVIEAARELSFGMAPRKDAGERA
The following text describes a protein:
Function:
Required for muscle development probably through the regulation of the actin-myosin cytoskeleton. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably through lamins such as epi-1, lam-2 and unc-52. Required for distal tip cell migration and dorsal pathfinding. Required for egg-laying. May play a role in cell motility and cell-cell interactions.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MREGSFPRRTRLLCLLAAVVLISTVTSFNIDTKNVVLHHMANNYFGYSLDFYNEQKGMPVLVVGAPEAETTNPNLSGIRRPGAVYACSVNRPTCREVHVDKMKGNLKKLNGSHLVPIEDKAYQFFGATVKSNDKHDKLLMCAPKYKYFYSKFEVIEPVGTCFYAENGFEKTEEFSSCKQEPARHGRHRLGYGQCGFSGAIPGKKNQDRVFLGAPGVWYWQGAIFSQNTKNQTDRPNTEYGSKEYDHDMMGYATATGDFDGDGIDDIVAGVPRGNDLHGKLVLYTSKLKMMINLTDEVSTQHGQYCGGALAVADVNKDGRDDIIMGCPFYTDYGSVKDAKTQERKPQYDVGKVIVFLQTAPGVFGKQLAVVGDDQWGRFGHSLAAAGDLNLDGYNDVIVGAPYAGKNKQGAVYVIHGSKDGVREKPTQKIEASQIGHGTARAFGFAVAGGVDVDGNGMPDIAVGAWKSGNAAVLLTKPVVTVTGATEPESALINVEEKNCDVDGKLGKQACRHINTCFKYEGKGDTPNDLEFDLRFNLDDHSPEPRAYFLQKDVKSDRSIKVASGSKTRDHPSSIEQRVRLEKGRQKCFRHRFFASSTMKDKLSPIHWSVNYTYVESKSGKLRGDKLEPAIDTTVPLSFQNKINIANNCGKDDLCVPDLKVTAVADREKFLLGTQDNTMLINVTVQNGGEDSYETKLYFDVPQGFEYGGIESVGADGSAPACSPTSDEPDSDGKWTFACDLGNPLPANKVVSSVVRVTASSDKPPLAPISINAHVNSSNDEEAHTIADNKVTFTIPVDFKNQLSLNGRSNPEQVDFSMTNKTRSDVFDDNEIGPVVSHLYQISNRGPSEIDAATLDIFWPSFSTEGGHLLYIITEPVVNPPNKGRCRVKQLQNVNPLNLRITNEHVPTEPPVAKTPNEYSREEDDESYEDETTTQSQTHHQTRTEHTQHHQGPVHVYERDEDKIRQNTGNWQYVEDKKKKGDYEYIPDDQEYDGDDFEDDDEDFDRAGSKRVKRAPVPKKKKKEGSRSGEPRSDKARFSDLREAVKLSKEAGGVVDYKGPLSRASVDCNGLRCTHIECDIYDLKEDEFVLVEIFSRLYTNTLVDERNPGGDISSLALARVTSTKYNWPHKPTLITAVSTNMNAIASEEGRDLPWWLYLLAILIGLAILILLILLLWRCGFFKRNRPPTEHAELRAEKQPAAHYADTQSRYAPQDQYSQGRHGQML
The following text describes a protein:
Function:
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B. As a consequence, the complex mediates transcriptional activation. In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton. Cell projection, growth cone. Note=Detected both in cytoplasm and nucleus. Colocalizes with RAC1 at actin-rich growth cones. Detected on the promoter region of actively transcribed genes.
Domain:
The Pro-rich region is important for the interaction with RAC guanine nucleotide exchange factors and the subsequent activation of RAC1, which then promotes lamellipodia formation.
Sequence:
MDGPTRGHGLRKKRRSRSQRDRERRSRGGLGAGAAGGGGAGRTRALSLASSSGSDKEDNGKPPSSAPSRPRPPRRKRRESTSAEEDIIDGFAMTSFVTFEALEKDVALKPQERVEKRQTPLTKKKREALTNGLSFHSKKSRLSHPHHYSSDRENDRNLCQHLGKRKKMPKALRQLKPGQNSCRDSDSESASGESKGFHRSSSRERLSDSSAPSSLGTGYFCDSDSDQEEKASDASSEKLFNTVIVNKDPELGVGTLPEHDSQDAGPIVPKISGLERSQEKSQDCCKEPIFEPVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVAGHPAGSTYSEQDILRQELNTRFLASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPFYRHSLFHSYPPAVSGIPPMIPPTGPFGSLQGAFQPKTSNPIDVAARPGTVPHTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSMFGHKDGPSVQNFSNPHEPWNRLHRTPPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHSSHPSPAPVLPVNALGHTRSSTEQIRAHLNTEAREKDKPKERERDHSESRKDLAADEHKAKEGHLPEKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESARPNSTSSREAEPRKGEPAYENPKKSSEVKVKEERKEDHDLPPEAPQTHRASEPPPPNSSSSVHPGPLASMPMTVGVTGIHPMNSISSLDRTRMMTPFMGISPLPGGERFPYPSFHWDPIRDPLRDPYRELDIHRRDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHHPLSVDPRREHERGGHLDERERLHMLREDYEHTRLHSVHPASLDGHLPHPSLITPGLPSMHYPRISPTAGNQNGLLNKTPPTAALSAPPPLISTLGGRPVSPRRTTPLSAEIRERPPSHTLKDIEAR
The following text describes a protein:
Function:
Involved in the synthesis of the atypical nucleotide dZTP (2-amino-2'-deoxyadenosine-5'-triphosphate). Catalyzes the condensation of aspartate with deoxyguanylate into dSMP (N6-succino-2-amino-2'-deoxyadenylate), which undergoes defumarylation and phosphorylation respectively by host PurB and guanylate/nucleoside diphosphate kinases to give dZTP. dZTP is integrated into the viral genome instead of adenine by the viral DNA polymerase. This Z-base probably completely replaces adenosine and forms a triple bond to the opposite T-base. The resulting non-standard viral DNA is called Z-genome. The chemically modified DNA is probably harder for the host bacteria to digest with nucleases or restriction enzymes (Probable).
Sequence:
MKKATVICDMQFGSTGKGLIAGFLAERDQPDVVVTAWSANAGHTYINREGRKWVHCMLANGIVSPKLKAVLIGGGSQMSIPTLISEIMGSLDILQGKSILIHENACIIQQRHVEEEAGPMTKIGSTKKGCGAAMMEKIRRNPESKIVAKDFIDDGLEIPDFKLDGTVGFKDISRHFEELGVCIKVVSNEVYLAVLHKAERVQVEGAQGFSLGLHNGFYPYVTSRECTPAQICSDCNVPISMVDKVVGTMRTYPIRVANRFDDEGKMVGWSGPCYSDQTELTWEQMGVTPEKTTVTKLTRRIFSFSRMQTRQAMLVCMPDEIFLNFANYCASEDELASIIEVISNEGGDVSYIGWGDSAAHIETTLEGDWSDDTNPLFNQYNKSSNIA
The following text describes a protein:
Function:
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Catalyzes Na(+) transport, most probably coupled to electron transfer from reduced ferredoxin to methanophenazine and heterodisulfide reductase. Involved in heterodisulfide reduction during methanogenesis from acetate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYPHRRADMNPISEFIRGITKDNPTFGLVLGLCPTLAVTTSVENGIGMAMGTLFVLVGSNMMVSAIRKGIPGTVRLPVEIIVIATFVTIVDMVMEAFTPDLYTSLGVFIPLIVVNCIVIGRAEAYALKNGVFYSIIDALGEGTGFLLVLILIGGIRELLGTGIIDPFGMTLINLSGVINPAMFMTMSPGAFLTIAVLMTIVNYRRQQKAAKGG
The following text describes a protein:
Function:
Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
Sequence:
MLSNRPITLRNLRFNPLDSVTFRMEPRRQKVPYEIQNDEDVDIIVKWKSTRARTFNTQPNYAIIRSKTKMTFQLVFKGMERGGNTPADRFTAVISAIKPTDQPAKQIWKLHELRSELLIGLKHKKFVFVIFEGVNEPEWWNRSVLGEDEPILPNFGIDKDDEEDAELQNNAMRAGAYQHVNLQLDPPGDPNQ
The following text describes a protein:
Function:
Involved in the cell growth and proliferation. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine (Probable).
Miscellaneous:
MISCELLANEOUS: B.subtilis has only one biosynthetic pathway from agmatine to spermidine to produce polyamines.
Subcellular Localization:
Cytoplasm.
Sequence:
MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGNMLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKKATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEPVGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYTANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK
The following text describes a protein:
Function:
Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MAASKSVAIVGGGISGLAAAFRLARRTSPTSYKVTIFESTDRAGGWIQSTVTDEGNVLEGGPRSVRPAGLSGRAALNLVYELGLQNSIIAVNSKHQAVSNRYIYVYNKLHKLPSGLMSMLKPISPFSKSLMYMILRDWWMHYGTKPSLKDSDESVYQFFQRRFSTEMADFLADPFCRGTSAGDARKLSMKACFPQVVNYEEQYGSILAGALLDKAIPISEADCPLVYQAKKERWRMWTLQNGMETLVNELFKQLTKCGVNIQLNTKCQQMSFLSDGKVMINSSEGLQDFDHVICALPAKNLGAILSSQHPTLSSKLSKIESITVAVVNLIYDEAIPAVNGFGHLVPSIESPGILGIIYDSCGFPQLDSKTKSSTRFSVLMGGAWFSQIHKENATDDYYIQMAVNAVRNQLGVKLEPSTVKLSMQRDCIPQYTIGHLPLVRQIFDYIAMHSLPMSLVGASYQGIGLADCIRNANLAADRI
The following text describes a protein:
Function:
Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSVRPKECPIQFPDIQRMMAAASELRLKVVGLYRSLYRTRQELFHGDQVALTVSLQKLRHGFLENKNEADPEKIKNPIFNFLNKLLHNQLIKLGEEVNYLLKHKTVQCQLNNTGNYEMKIRKDTTLLDNAVYPNDKR
The following text describes a protein:
Function:
GTPase activating protein for GPA2. Negatively down-regulates glucose-induced cAMP signaling via GPA2.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASVPSLCDILIPLEKNSRSDGDAESSNTVLIQLRKGHHERMRSPYTIQKFYKFLKRAHCEENLEFFEKAHQFLQLKQNRSISEEKLLEVWNKSLYIKYIAVDSPKECNFSQDTREIFEKCFANNEVPADVDVLCAISHVMGLLMDGYHRFVSSVNEKKYSATYAHNDSATEQDLKNESTTSFSSLGVEDISEDRNSYLKKPDINGLSTIIQETSANTTNESQCSDRTSRPSESSSSLNTTSSTYKNTSTRNLQKPQNTGILNSGKGLLQKLNFVKKRKSFKQPSGVICSHYNSNVQNRLKGQNSHQQR
The following text describes a protein:
Function:
N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEYDEEEVKVLKEVLSAFFLYRQYAHTITQQKRKSMSRLSFEHKDLLLQDSDNNFLKHLSRIDQCIEQNSVLAEAIANAAIPVFCSDFDQNELFHVNVDMMQKVSSTLKQIARDWSTECVEERRTTYAPFIEELNSLFPSDSIDRSKIRVLVPGSGLGRLAFDIAVEGFACQGNEFSYFMLLTSHFILNCVKQENQFLVYPYIHSFSNHVMRDDQVRSLNIPDAVPSQYLRNSQNFSMAAGDFLEVYGTEESRDSFQVVATCFFIDTTKNILDYLDTIKNCLVDGGYWINLGPLLYHFESEGTSNSNSDSQQQPFVELTLEQLFYVMDSMGFEVLKHNSVDTTYMGDKRSMLEWIYHPHYWVCRLQKSKLRFQ
The following text describes a protein:
Function:
Essential for the replication of viral ssDNA. The closed circular ssDNA genome is first converted to a superhelical dsDNA. Rep and/or Rep' binds a specific hairpin at the genome origin of replication. Introduces an endonucleolytic nick within the conserved sequence 5'-AGTATTAC-3' in the intergenic region of the genome, thereby initiating the rolling circle replication (RCR). Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester. The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase. The polymerase synthesizes the (+) strand DNA by rolling circle mechanism. After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication. Displays origin-specific DNA cleavage, and nucleotidyl transferase.
Miscellaneous:
MISCELLANEOUS: [Isoform Rep]: Produced by alternative promoter usage; MISCELLANEOUS: [Isoform Rep']: Produced by alternative splicing of isoform Rep; MISCELLANEOUS: [Isoform NS515]: Produced by alternative promoter usage; MISCELLANEOUS: [Isoform NS672]: Produced by alternative promoter usage; MISCELLANEOUS: [Isoform Rep3a]: Produced by alternative splicing of isoform Rep; MISCELLANEOUS: [Isoform Rep3b]: Produced by alternative splicing of isoform Rep; MISCELLANEOUS: [Isoform Rep3c]: Produced by alternative splicing of isoform Rep.
Subcellular Localization:
Host nucleus.
Domain:
There are 3 rolling circle replication (RCR) motifs. RCR-2 is probably involved in metal coordination. RCR-3 is required for phosphodiester bond cleavage for initiation of RCR.
Sequence:
MPSKKNGRSGPQPHKRWVFTLNNPSEDERKKIREPPISLFDYFIVGEEGNEEGRTPHLQGFANFVKKQTFNKVKWYLGARCHIEKAKGTDQQNKEYCSKEGNLLIECGAPRSQGQRSDLSTAVSTLLESGSLVTVAEQHPVTFVRNFRGLAELLKVSGKMQKRDWKTNVHVIVGPPGCGKSKWAANFADPETTYWKPPRNKWWDGYHGEEVVVIDDFYGWLPWDDLLRLCDRYPLTVETKGGTVPFLARSILITSNQTPLEWYSSTAVPAVEALYRRITSLVFWKNATEQSTEEGGQFVTLSPPCPEFPYEINY
The following text describes a protein:
Function:
Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
Subcellular Localization:
Golgi apparatus, cis-Golgi network membrane; Single-pass type IV membrane protein. Golgi apparatus membrane. Endoplasmic reticulum membrane. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus.
Sequence:
MESLYHQTNNVVKDIERDFQRLSQLSAQESLDVENGIQLKITQANANCDRLDVLLYKVPPSQRQSSKLRVDQLKYDLRHLQTSLQTARERRQRRMQEISEREQLLNHRFTANSAQPEETRLQLDYELQHHTQLGNAHRGVDDMIASGSGILESLISQRMTLGGAHKRIQAIGSTLGLSNHTMKLIERRLVEDRRIFIGGVVVTLLIIALIIYFLVL
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB26.
Sequence:
MIIDTSALLAYFDAAEPDHAAVSECIDSSADALVVSPYVVAELDYLVATRVGVDAELAVLRELAGGAWELANCGAAEIEQAARIVTKYQDQRIGIADAANVVLADRYRTRTILTLDRRHFSALRPIGGGRFTVIP
The following text describes a protein:
Function:
Has a role in the ecdysone induced cascade; probably indirect control of 'late' ecdysone genes.
Sequence:
MPSGVFQKRPKAAETISLFCMILIRLSRAADDSHETSTLLATITTITTEIIPMPDSGRSCFGWSSAPEAAGGNCSRSNRNGTLKCYGGMNNLAALNQSGKLSRVQPALEMLLCGWPKDGLNHFRDLQKLPRLRSLTIEYSGFTEFKFDFPEMLELHTINISWTNLSYISSRTFKRVHPLKVLDLRWNQLIQLDGPLLLPRNFEQLYLAGNPWNCTRNFKWLLLQPEKGRLVVDRDELICTDRKYKERQMLMVMHYKLELKRQCQSHEDLRNCTCLMHHILPKTHIPLYTVNCSHLQFHRLPDFLPDNTTTLVINDNMISDINPLRDNPHYRHVVDMQLENNQISNVDNLEDTYWLQNFRLLNLRGNNLRKLHVYALDNALDDNENANLLLLSRNPWHCTCKFGSRMRELLTKYKDIVRDAWNVSCTYRLDDDQLLAKVLTLSRQEMCNLSVEGGTQIHPIDWLNGVLASLIFLILGKLAYDYYYYKYYGRVPWIVMKMP
The following text describes a protein:
Function:
Processing of precursors of alpha-factors and killer toxin.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Sequence:
MKVRKYITLCFWWAFSTSALVSSQQIPLKDHTSRQYFAVESNETLSRLEEMHPNWKYEHDVRGLPNHYVFSKELLKLGKRSSLEELQGDNNDHILSVHDLFPRNDLFKRLPVPAPPMDSSLLPVKEAEDKLSINDPLFERQWHLVNPSFPGSDINVLDLWYNNITGAGVVAAIVDDGLDYENEDLKDNFCAEGSWDFNDNTNLPKPRLSDDYHGTRCAGEIAAKKGNNFCGVGVGYNAKISGIRILSGDITTEDEAASLIYGLDVNDIYSCSWGPADDGRHLQGPSDLVKKALVKGVTEGRDSKGAIYVFASGNGGTRGDNCNYDGYTNSIYSITIGAIDHKDLHPPYSEGCSAVMAVTYSSGSGEYIHSSDINGRCSNSHGGTSAAAPLAAGVYTLLLEANPNLTWRDVQYLSILSAVGLEKNADGDWRDSAMGKKYSHRYGFGKIDAHKLIEMSKTWENVNAQTWFYLPTLYVSQSTNSTEETLESVITISEKSLQDANFKRIEHVTVTVDIDTEIRGTTTVDLISPAGIISNLGVVRPRDVSSEGFKDWTFMSVAHWGENGVGDWKIKVKTTENGHRIDFHSWRLKLFGESIDSSKTETFVFGNDKEEVEPAATESTVSQYSASSTSISISATSTSSISIGVETSAIPQTTTASTDPDSDPNTPKKLSSPRQAMHYFLTIFLIGATFLVLYFMFFMKSRRRIRRSRAETYEFDIIDTDSEYDSTLDNGTSGITEPEEVEDFDFDLSDEDHLASLSSSENGDAEHTIDSVLTNENPFSDPIKQKFPNDANAESASNKLQELQPDVPPSSGRS
The following text describes a protein:
Function:
Is able to bind two actin monomers at high concentrations of G-actin. Inhibits actin polymerization by sequestering G-actin and stabilizing actin dimers (By similarity).
Sequence:
MSTTANPLLAEINKGTDLKHAETQDKSAPIIENVPIKKNDHSSLLGEVEKGAQLKHVETQDRSAPVTEGATVKSNNHSALLGEIKSKAQE
The following text describes a protein:
Function:
Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome membrane; Single-pass type I membrane protein. Mitochondrion membrane; Single-pass type I membrane protein.
Sequence:
MEGKWLLCLLLVLGTVAVQAHDGHDDDMIDIEDDLDDVIEEVEDSKSKSDSSTPPSPKVTYKAPVPTGEVYFADSFDRGSLSGWILSKAKKDDTDDEIAKYDGKWEVDEMKDTKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTSELNLDQFHDKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGVYEEKHAKRPDTDLKIYFTDKKTHLYTLILNPDNSFEILVDQYVVNSGNLLNDMTPAVNPSREIEDPEDQKPEDWDERPKIPDPDAVKPDDWDEDAPGKIPDEEATKPEGWLDDEPEYIPDPDADKPEDWDEDMDGEWEAPQIANPKCESAPGCGVWQRPLIDNPNYKGKWKPPMIDNPNYQGVWKPRKIPNPDFFEDLEPFKMTPFSAIGLELWSMTSDIFFDNFIISGDRRVVDDWANDGWGLKKAADGAAEPGVVGHMLEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQSNAMEYKKTDAAQPDVKEDEGKEEEKNKGDEEEEEEKLEEKQKSDAEEDGGTGSQDEEDRKPTAEEDEILNRSPRNRKPRRE
The following text describes a protein:
Function:
Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MGLWGQSVPTASSARAGRYPGARTASGTRPWLLDPKILKFVVFIVAVLLPVRVDSATIPRQDEVPQQTVAPQQQRRSLKEEECPAGSHRSEYTGACNPCTEGVDYTIASNNLPSCLLCTVCKSGQTNKSSCTTTRDTVCQCEKGSFQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIKCKNESAASSTGKTPAAEETVTTILGMLASPYHYLIIIVVLVIILAVVVVGFSCRKKFISYLKGICSGGGGGPERVHRVLFRRRSCPSRVPGAEDNARNETLSNRYLQPTQVSEQEIQGQELAELTGVTVELPEEPQRLLEQAEAEGCQRRRLLVPVNDADSADISTLLDASATLEEGHAKETIQDQLVGSEKLFYEEDEAGSATSCL
The following text describes a protein:
Function:
Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEKLLAFSTQLQAQGNSSNSPPDPKDLDPSVLDHIFGANPADEMRKAMDAIEDPSVPLDQKEIAFDNLEMLVEHIDNANNLVPLQLWPRLLKQLESPESTLRRLAAWTIATAVQNNPKSQQALIENDGLKILFGALKKEDSDETKNKVLYAITSELKLNEAGIALLDKIPNSWEMLIEILELKHSVMTKRVIFFFYALLIQEDKSKQIILQKAHEFQIPEKVYQFSLEHSVDEDCVTKSLHTLYLFQKNKVSVANTNELLKSLVQFKSEFPEIFTVDEWKAFHEALE
The following text describes a protein:
Function:
Mitochondrial RNA-binding protein required for the stability of the cox2 and cox3 mRNAs.
Subcellular Localization:
Mitochondrion.
Sequence:
MLKRAHYVALHVTLNHNGLSYQRVFSCLTQFPMLRHSSTAAKNNVSMISKFQAPEDKFFPSFSLKSMPKQSSHMSASLLNSLNTSMKKSFSRKKYREAVSLFRKNLWKYEESWIRNQDFIDCCIIACSAYEKLCQPLRIKKTFIILSQLCPKLPAELCRVFLSYATGCVNYGHNVALTCFENSPKELIDYNYWLSWLSFSKSSPVVLWLTFTRISSAGLSPNAETFEILLVAFASQKNFWFFEKTYDLFMQSKLTWRPFTYRVLIESFMKFGNFEEAEKLAYSYVKNKIDSLSSDVFFSAILKFYAVGGDFQGFKKLLSFMTDYNVNFSVSTLNQLLRLNLYHAMDEKISTFSSEHITKLIEQQIKPDLESMLIISEYLNEYKPSPKMRELINWLYSNFHLPKTVSLHFLREVQSLVFRYPLLHSKIHLAISTLKDSGCDWNVGLSYLNWLFVNKRITEAINFFYTITINAGTRPPNELFDVFISNLLKFTSAETTSSAIRKVQSKYPSMCGSSPAIKLILFSKSFSVLQSTSEKIEQLLVSFQRNPSAYSKSFTLALAEWLFSRRLFQSALLYSFKVSDVDDSHFSFRSQILICWCYYRLNDFKSLIQHTNNLLQSNNASLLRRLAATLYRIQIRENNGYKRVLLDRLRKKAILRAFPSRTLNRTEKVKLYNEDAKFRSIFSRVLLHQSHLGNVIS