lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor system, becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes, including the amino-acid permeases BAP2 and BAP3. Binding to promoters is facilitated by DAL81 (By similarity). Involved in the repression of genes subject to nitrogen catabolite repression and genes involved in stress response. Negatively regulated by inner nuclear membrane proteins ASI1, ASI2 and ASI3, which prevent unprocessed precursor forms that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes.
Miscellaneous:
MISCELLANEOUS: Present with 6490 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Localizes to the cytoplasm in its unprocessed form and is targeted to the nucleus after proteolytic processing upon induction by amino acids.
Domain:
The N-terminal inhibitory domain contains conserved sequence elements important for cytoplasmic retention (Region I) and proteolytic processing (Region II) of the protein (By similarity). Region I is also required for ASI1/2/3-mediated negative regulation of transcription.
Sequence:
MPILSLSSTRNSVLTRIYDYLKALVQQVIVPNVEDDKSSKSTPFEKLEPAKQNHPQKDCCATEKDDLVDVSELFPKQNNKQLSLTSKSSVVPCALNLDNLETPFSIKIDNNGAVTTQLNLDEPILRGPSRGEPAKLQNDLISSPPLEESYINNDQYKALFPSNFLPITPVSSVITPASKKSIDESPLSDEVQGIADESSETLPYICHYCDARFRIRGYLTRHIKKHAKRKAYHCPFFDNSISQELRCHTSGGFSRRDTYKTHLKSRHFTYPEGVKPQDRNKSPGVCTQCGEHFSTSESWVENHIEAGSCKGLPEGYSEGIREKKKTSKMKMIKTSDGQTRFISSDESVSEPALQNKNCIEATVMQSKERPNDKIIPTKTEKNDFGIGTQWFERKQISRPTQTTQSRGPTEVQNLKEWSIISPPILSPQNASSVPQEYQSSRYTLHMDSPALSSASSALSPLSGDPITTTETNKSYPLDSEQSLLEPDKTEEDAINQSKESNMISINEMLQKQMDFELLGENHLKETQDYLALYKKAYGIEF
The following text describes a protein:
Function:
Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MVYGPSMLPTLNLTGDVLLVEHLSPLLDKLGPGDVILVRSPENPRKTVTKRIIGMEGDTVTFLADPSRSDRYISLKVPKGHVWIQGDNIFASKDSRQLGPIPCGLILGKVLYRVWPPEGFGSL
The following text describes a protein:
Function:
May be involved in endocytic recycling of growth factor receptors such as EGFR.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAAGVPCALVTSCSSVFSGDQLVQHILGTEDLIVEVTSNDAVRFYPWTIDNKYYSADINLCVVPNKFLVTAEIAESVQAFVVYFDSTQKSGLDSVSSWLPLAKAWLPEVMILVCDRVSEDGINRQKAQEWCIKHGFELVELSPEELPEEDDDFPESTGVKRIVQALNANVWSNVVMKNDRNQGFSLLNSLTGTNHSIGSADPCHPEQPHLPAADSTESLSDHRGGASNTTDAQVDSIVDPMLDLDIQELASLTTGGGDVENFERLFSKLKEMKDKAATLPHEQRKVHAEKVAKAFWMAIGGDRDEIEGLSSDEEH
The following text describes a protein:
Function:
May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments. May also play a role in axon outgrowth and guidance.
Miscellaneous:
MISCELLANEOUS: [Isoform Iqcj-schip1-1]: Based on a naturally occurring readthrough transcript which produces an IQCJ-SCHIP1 fusion protein; MISCELLANEOUS: [Isoform Iqcj-schip1-2]: Based on a naturally occurring readthrough transcript which produces an IQCJ-SCHIP1 fusion protein.
Subcellular Localization:
Cell projection, axon. Cytoplasm. Note=Localizes to the axon initial segments (AIS) and nodes of Ranvier of neurons and is absent from dendrites.
Sequence:
MRLEELKRLQNPLEQVDDGKYLLENHQLAMDVENNIENYPLSLQPLESKVKIIQRAWREYLQRQDPLEKRSPSPPSVSSDKLSSSVSMNTFSDSSTPDYREDGMDLGSDAGSSSSSRASSQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQKKVIDEWAPEEDGEEEEEEDDRGYRDDGCPAREPGDVSARIGSSGSGSRSAATTMPSPMPNGNLHPHDPQDLRHNGNVVVAGRPNASRVPRRPIQKTQPPGSRRGGRNRASGGLCLQPPDGGTRVPEEPPAPPMDWEALEKHLAGLQFREQEVRNQGQARTNSTSAQKNERESIRQKLALGSFFDDGPGIYTSCSKSGKPSLSARLQSGMNLQICFVNDSGSDKDSDADDSKTETSLDTPLSPMSKQSSSYSDRDTTEEESESLDDMDFLTRQKKLQAEAKMALAMAKPMAKMQVEVEKQNRKKSPVADLLPHMPHISECLMKRSLKPTDLRDMTIGQLQVIVNDLHSQIESLNEELVQLLLIRDELHTEQDAMLVDIEDLTRHAESQQKHMAEKMPAK
The following text describes a protein:
Function:
Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.
Sequence:
MSILVTGANGQLGTELVQLLKEHNLTVTEWDKDSVDIVDKAAVKKAMLDLKPEWIIHCAAFTNVEAAEDELKNVNWEVNVDGTENISEAAEIVGAKLVYISTDYVFDGTKKEAYLPDDKTNPLNQYGIAKLAGEKVALEKNSQTYVIRTSWVFGKYGNNFVYSMLKLAETHKELKVVNDQLGRPTYTYDLADFIRFVIEKNPAYGIYQFSNSGTATWFEFATEILKDKDVTVNPCTSDEFPQKAERPKTSIMSLEKVEKLGFNIPTWQDALVRFKK
The following text describes a protein:
Function:
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines, but also purine-derived lesions, alkylation damage and cytosine photoproducts generated by UV irradiation as well as abasic sites. Also has 8-oxoguanine DNA glycosylase activity. The AP lyase can incise AP sites opposite all four bases. May also play a role in the regulation of mtDNA copy number by introducing a double-stranded break (DSB) at the mtDNA replication origin ori5, initiating the rolling-circle mtDNA replication.
Miscellaneous:
MISCELLANEOUS: Does not possess a consensus sequence for a C-terminal iron-sulfur center typical of all other endonuclease III homologs.
Subcellular Localization:
Nucleus. Mitochondrion. Note=Relocalizes to organelles containing elevated oxidative DNA damage.
Sequence:
MQKISKYSSMAILRKRPLVKTETGPESELLPEKRTKIKQEEVVPQPVDIDWVKSLPNKQYFEWIVVRNGNVPNRWATPLDPSILVTPASTKVPYKFQETYARMRVLRSKILAPVDIIGGSSIPVTVASKCGISKEQISPRDYRLQVLLGVMLSSQTKDEVTAMAMLNIMRYCIDELHSEEGMTLEAVLQINETKLDELIHSVGFHTRKAKYILSTCKILQDQFSSDVPATINELLGLPGVGPKMAYLTLQKAWGKIEGICVDVHVDRLTKLWKWVDAQKCKTPDQTRTQLQNWLPKGLWTEINGLLVGFGQIITKSRNLGDMLQFLPPDDPRSSLDWDLQSQLYKEIQQNIMSYPKWVKYLEGKRELNVEAEINVKHEEKTVEETMVKLENDISVKVED
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
Sequence:
MKTTISAQLGQQLHLTPQLLQSIRLLQLDGMQLELEIRRALETNPLLELEELADSSDEAPSAEDGATDMAAFDELPESTMWEVQSSSWNGEDDDRMQRVAAGESTDPHVRILRELALDLDETDLGTAAFWLEQTDDAGYLTEALPTLQQLAATRLGISVDAAEAIRQRLLHGDPAGLAACDLRECLQAQLAALPGRVPARHLAGRILAGDLDLLAGHDYALLARAHDADVDDVREAVRLILSLQPRPGDDLLQETNASVIPDVLAWHADGSWRVALNPATTHRVSINPVHERALAEAGDAAQPLRDMLQEARWLTRGLSMRYETLLRATRAIVERQAAFLARGEEAMAPLTLKEIADEIGMHESTISRITTGKYIQTPRGTFELKHFFAVRLEGASVSGQAVKAMVRRLIESEPAGRPLADEAIAGLLSRQGVNIARRTVAKYREQLDIAPARERRRTTKPLLARAG
The following text describes a protein:
Function:
May operate as a cation/H(+) antiporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDPKLLFCLPQGDALFNPLNTMFIQMACILVFSQLFFLLLKPCGQAGPVAQILAGIVLSPALLSRIPKVKEFFLQKDAADYYSFFSFALRTSFMFLIGLEFDLQFMRRNLKKVTVITISSFVSCGLLSLGFFYLLKPLLHIKEDYFTFFLVLFITLSNTASPVVLRSIADWKLNTSEIGRLTISCALLNELTNVVVYTLIIAVVSGKLIGDLFLFIFMTGALILLNRFLAPWLPKRNPKEKYLSKAETLVFFIFLLIVAITIESYDVNSSVSVFIIGINFPRQGKTHRTLINRLSYPIHEFVLPVYFGYIGFRFSVIGLTRRYYIVLVIIVILTLVGKFIGVISACMYLKIPKKYWLFLPTILSVKGHVGLLLLDANYAEKKWWTTTIHDMVIAALVITTLLSGVLASFILKAREKDFAHQKTSLESHDTSEELRVLSCVYGARCARGEISLISSLSGSHGGSKPFTPLLMHLVPLPKKRKSELLYHEHDEDVHVDDDFGTNESLMVNDSIDSFAKDSKILIQQVKLVTQMVSMHEEICNATEDLRVNIVFLPFHKHQRIDGKTTNDGEHFRQMNRNVLRHAPCSVGILVDRNITGFQQPHGFGSVQNVAVLFFGGPDDREALALCKWFANNTLIHLTIIQFVPEDSHPESPVRNATTRDSSEVLIDVQGRDQSEHEADRSLLEEFHNRFVSTGQVGFIEKRVSNGPHTLTILREIEELYSLFVVGKSRGDCPMTVRMKDWEECPELGTVGDFFASSLDVNASVLVVQRQRNSHDDFIDD
The following text describes a protein:
Function:
May be a carrier protein for lipids.
Subcellular Localization:
Secreted.
Sequence:
MKLFILLSLLSVCYARKEWFDKDPQDVAKWQKECFEASGVSMESMNKLPNITLSEDPKLGENAFCLLKKLGFISEDGTLLIEKLRTSLKNQWGDEIANKLVNECARQKSTPQETAHEMFLCIPAKLK
The following text describes a protein:
Function:
Functions as a guanine nucleotide exchange factor (GEF) activating either RalA or RalB GTPases and plays an important role in intracellular transport. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. During bacterial clearance, recognizes 'Lys-33'-linked polyubiquitinated TRAF3 and subsequently mediates assembly of the exocyst complex.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes mainly in the peripheral region of the cytoplasmic membrane in oocytes and in preimplantation embryos until the 8-cell stage. Between the late 1-cell and the early 2-cell stages, nuclear localization becomes stronger. After the 4-cell stage, not detected in the nucleus.
Domain:
The Ras-associating domain interacts with Ras.
Sequence:
MVQRMWAEASGPIGGAEPLFPGSRRSRSVWDAVRLEVGVPDSCPVVLHSFTQLDPDLPRLESSTQEIGEELINGVIYSISLRKVQLYPGATKGQRWLGCENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTVFLCTYRAFTTTQQVLDLLFKRYGCILPYSSEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEDLEPSEVEPEALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPAPELDPTVSQSLHLEPAPVPAPALEPSWPLPETTENGLCAKPHLLLFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRAKKGKEHLAPTIRATVAQFNNVANCVITTCLGDQSMKASDRARVVEHWIEVARECRVLKNFSSLYAILSALQSNAIHRLKKTWEEVSRGSFRVFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPRRTQRRQKETGVIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIVPEEHFGAWFRAMGRLSEAESYNLSCELEPPSESASNTLRSKKSTAIVKRWERRQAPSTELSTSSSAHSKSCDQLRCSPYLSSGDITDALSVHSAGSSTSDVEEINMSFVPESPDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVSTTRTHKRSVSGVCSYSSSLPLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELLQIISEDHKLKIPENANVFYAMNSAANYDFILKKRAFTKGAKVKHGASSTLPRMKQKGLRIARGIF
The following text describes a protein:
Function:
Participates in transcription elongation, termination and antitermination.
Sequence:
MAEPKWFVVHTLAGHEHKVKAILERQVKLNHLEDKVFEIVVPEEKVMTVKGGKKRIQVKKVFPGYLFIRMIEDEDVIRMIRNTTGVTGFVGTPGRPSTLNPQEEHWIRRFLEQKEIRPELKVKKGDRVYIKSGPFMGYEGFVDEVYPEKGTVRVLLSIFGRETPTEIDHTQVEKTD
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDFPFQAPIPPLTANYQSEPEKIGQATDMMIKRVTDAKKMIEELLQMLDLQEKCPWPDMLEKFSSLASAMASLQTSVRKSGLPHGHEDHGQFLRSHVLVPQRLQYEPDEALLRVTQGRVFSWNHELVPEYLRTKPNPEMENEEQMLDMERSAKAPDLVVKQIAAYNKNIEGLLGSLSNIDRLHSEAIIEKPTHSREETMKLVKSILLGEAIRTLRTAGAPPTSTPMPAAPGSAGPSQSGSQVMNQAPGMQDYQNPQLRQQLMGQPPQMGYGNAYPPQYPQMHPQQMGELSGNSF
The following text describes a protein:
Function:
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
Subcellular Localization:
Mitochondrion.
Sequence:
MVVYLIKASTMHCSPFKVCALQSWLITRISSKSLSSVSCLAHTSTPWKTARSYPSEFSRPCPTRIHLKNTNSCLFSASAHSQHSSATIDPQFIRNLGIIAHIDAGKTTTTERMLYYVGYTKRLGNVDEGSTVTDYLKTEKERGITIQSACIPLAWKNHRLNLIDTPGHVDFTIEVERSLRVLDGAVCVLDGVAGVEAQTETVWAQSNRYSIPRIAFVNKLDRDGASFKNTVHAMSKRLGGWGKPAIIQLPIFRNGHGVLVTDSHGGGKLEGIVDLLTMERLDWFKDPSSGGVVTRSQLTLGEKEWALVYEDAVKYRNMLIETLSEMDDGIVNVFLECDGDHAQVPAKEIQNACRRATISGQAVPVLCGASFRNIGVQPILDAIVNYLPSPMDAPSAIATLSNGSQQHILLKDPNMTALAFKVVHDSSRGPLVYVRVYSGTLESRSILHIAGSSTGIGRDCKPIKERATKLLELYADDYDEIPLISAGNIGAIVGLKHVKTGDTLLASTDKRAIQLHSIPIPPPVFVRSCEAESISSEKAMAAALESLCREDPSLTVTVNDETGQTLLSGMGELHLEIAGERLQEVYNVKCNLGKVEISYRETLQAGQTYSHEMVYDSQVFGKHFKCTVELEMESIDNTDAGESISLATDGIIVDARLKEHQITLAEDGRQLTAFAPLSELSEAAEMGIRGALSRGPILGLPVSQVSVRVKQVSLFNPEISTPSSVRTAAYNCVRAIFQTADKRIIEPVMDLSVRVANQYVGSITKDLTGTRKGQVLGVNAMDLDGADSNNSSEKHVIHARVPLAGLVGYSSQLRALTAGTGEFLMALHGYEPMSHDKEELLIRTMRGY
The following text describes a protein:
Function:
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex seems to link protein degradation to sexual development.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPDEAISILSQKSSDSGLHIQLHPLALLTISDHITRHAARSQQGPIVGGLLGQHNGREITVEHGFECVVEIGPNGEAQLPNEWFVDRVKQFKDVHKVPALDLIGWWSTAPPSGPTTAHLPIHRQILQNHNESAVFLTFHPSQVQGASQSQGKLPLTIYESVYEGESVTENGKAMQVDGEEQLLNIRFRELPYTIETGEAEMIGIDTVARTARNAAATETSTVAAPSSQIDSDKQEQQPANTDLLSPEEEELIASLNTRLNAIRTLESRISLIKSYLSSISPSSEEGQKDSATKPDHTILRDINSLLSNLSLLTPHEQSAFSAETLAQNNDVSLVALLGQLSQSVNGMREVGKRTAIVNSVRRNRKQLGAQSRYEDDILGRDGVALG
The following text describes a protein:
Function:
High-affinity sodium-dicarboxylate cotransporter that accepts a range of tricarboxylic acid-cycle intermediates with 4-5 carbon atoms. There is no interaction with monocarboxylates. Plays a role in the regulation of life span.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSLSLHLSGWPENSESRQRMLESSSSTNFVQHFVSREISNKERLLSLFRRLRNGLVLVLTPLFFGQMLNWEGPEWKCAYCVCIIAVYWMSEVMPLAVTAMLPVVLFPLVGVLDANTTAKEYMNDTNFLFIGGLIMAAAVEKCDLHERVALSVLRCVGSEPKWIMLGFMTVTALLSSFISNTATTAMMVPIGQSVVQQLISSFQHHPTNGERGRLGCKKMATGLVLSICFAANIGGTGTATGTPSNLVMLGQLSALFPKVDGSLNYVTWIFFAYPLMLLCLFVAWMTLVSFFLRDAPEKDEAVTEMLKTRYNELPRMTYAEKSVFVCFCILLSLWVFRNPGVVPGFGVFFKKGAYTDATSAMIVAFLLFVLPSERPDLATYIKKEDLKKRGCLMDWKTMQETFPWSVVLLLGGGFALAAGVKESGLSLLIGNSLSSIEHLPLWILQLLTMLIAMVITNICSNTVTASIFVPIVATLAQRAGHHPFTLMLPTTLASSFAFIFPVGTPPNAIVFGSGMVKVSDMAFVGGIISLELLVLTVLYMNSIAYLTLPLLEFPTWAIIANSTMQQ
The following text describes a protein:
Function:
Positive regulator of thiamine biosynthesis.
Subcellular Localization:
Nucleus.
Sequence:
MVNSKRQQRSKKVASSSKVPPTKGRTFTGCWACRFKKRRCDENRPICSLCAKHGDNCSYDIRLMWLEENIYKVRKHSLISSLQARKSKSKPLCQKISKSRFKQMTHFRQLSPPTSDCEDSVHEASKETTLPNDNTFTISVRRLKIYNNAVASVFGSMTNRDYTQKRIDKKLDELLNMVENDISVVNLNCSKHGPYSVFRANPAAVTSALTDQLPSPGHSMSSAEETTTAALSSPPEDSTSLIDIIQGKIFGILWFNCYGNMILNRQEYTTWFINKMRNSLTTEFIRFLGKIIDDPDINMASCLFKECIARWSCVDWQSIAITMLVIIHGYTCPNLTKLLRVWFLQQKLLRFSMYPLVNFIINNTQDLDVLYHCNGLLGNADLFEDPYQDELTSELHVLVTERLVNSWKDTILQQLCSCQDTTLSCSQLRYWQLQLKCNQQFYKDVYAMQD
The following text describes a protein:
Function:
Orphan nuclear receptor and probable transcription activator, required during development. Plays a role in male tail tip morphogenesis regulating the expression of the transcription factor dmd-3 in a negative feedback loop. Regulates vulval precursor cell (VPC) differentiation, in concert with homeobox protein lin-39. Involved in promoting embryogenesis, in concert with homeobox protein nob-1. May play a role in modulation of lifespan and immunity.
Subcellular Localization:
Nucleus.
Sequence:
MTDVERMVLRPNHEGEMCPVCGDRVSGYHYGLLTCESCKGFFKRTVQNKKQYQCSAEANCHVDRTCRKRCPSCRFQKCLTMGMKMEAVRADRMRGGRNKFGSFYKKDRAHRMQRNAMRVSTVQVPAVLGAQSQAQTFYQPPEHQVSSSTTDQNNQINYFDQTKIKTEYIKTEYDAHLQSPTLSSSTNQQLSVSDFIMRPGYLVDPQDSLAVLLGSTIDDPLLRHTFPAAYQLNEVKQEPFDYSEQFIHHSLHDYPTYTSNTTNYATMMPMTTVSSTQSLVTSTSSTTTGRMTEASSTSPILPLCPAPTEKTVDHFYNSSIAEMCKTLPDDAQIARIFTSVKGTSKPEKHAFSIQVAEENLKDIVIWAKNDQLFSKLSLDDQMILLQTSWTTVHIVDITNAMVHGNLLSQYKMSNGDEVPVGLVALLGNQTFVSSWNDVVIRLRNMGFTNFDYCAFRFLALFDQSMDSFPAVSTARSRVLQSWREVRCTTAFLEIFEQIRRLAYDSLRYLWNLHSNCPTNWEQFFPEASLVLEMIRTTVNRSASSSVTAITQVPAIQLPTPQATYTAVPYMAS
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MARGGIRRSRCDENARRAEEEEAEAVKRAKGADYGSAREKEGTGSSKEQQQSRKGKKSGRRRGRAKKDGSSMATALLPINENASGSSLEGGIAKKDEDLLVDKAKNVEVEAVAFVESTKPASLSEDGEVELSSSSCMHSPESPKERTVIWSNAAFCSEQQTQTPTATMSVEKSVLVCNDDTVAGMELMTAEDGLKDTKGSDGSSAVKLSLAVEANEVHEVKVPEKNEMTAIVEEDEVDHLEKEIENEIALLTKRLAELRAKREAKHKTQERAKRALSCPPTPLSSGLQEQTNDGDKSKSRGKGRMVSAKFLQWPTKSPDLEPKTSEKQASFRRNEATTISFQATPTNAVTPFSKGTSTGAVTSFSKATTPHHGRAPVPDAEQKETFLKSAPRVSVPDAEQKESSLKSAPRVPVPDAEQKESSLKSAPRVLLRSKAIEKLQAGAGLKCLARPASSLKSSYRCSLDGNFIEQIRNLSLSPATSNVSEASKKFDWTKSLRSGATVEKRPQVDESHKKAKGTPEAQLLVDLKESNKASKVSPSVTRKVRNVASRYNESPAQHQPTRKRSLDIPSQASPDTGGAAPAASSHRKRVSLDQQQQQEQAVDAANPPARKSGIGAAARSGLSRLRPRNPASREAMKTPPMRRDGLESELKKLPGLVINREVEYSPRDSGCVKRASQQGGKKSFFLSTESWDAGHREEKEEGQEIMAGAPPPDDSSLVVVLLDTSLHFWNAVVRSSSGLQQVLSFLNSLALMNHMNHLVIIASGCNSCEFLYDSLDSDERAGANHQTASEKIVHKLNDFVSRDATQPPKFQPSLLSASLSMALCYIQRALKEKIGPSKPRMLCLQASPDAPHQYIAIMNAIFSAQRSMVIKFHELYQETYINHLLLPFRCQSMRAWSVLNIRPFFNRPRTLPVELT
The following text describes a protein:
Function:
Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3' of the cis-acting dehydration-responsive element (DRE). Binding to the C-repeat/DRE element mediates high salinity- and dehydration-inducible transcription. Involved in drought and heat-shock stress tolerance.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: Inactive.
Subcellular Localization:
Nucleus.
Sequence:
MTVDQRTTAKAIMPPVEMPPVQPGRKKRPRRSRDGPTSVAETIKRWAELNNQQELDPQGPKKARKAPAKGSKKGCMKGKGGPENTRCDFRGVRQRTWGKWVAEIREPNQQSRLWLGTFPTAEAAACAYDEAARAMYGPMARTNFGQHHAPAASVQVALAAVKCALPGGGLTASKSRTSTQGASADVQDVLTGGLSACESTTTTINNQSDVVSTLHKPEEVSEISSPLRAPPAVLEDGSNEDKAESVTYDENIVSQQRAPPEAEASNGRGEEVFEPLEPIASLPEDQGDYCFDIDEMLRMMEADPTNEGLWKGDKDGSDAILELGQDEPFYYEGVDPGMLDNLLRSDEPAWLLADPAMFISGGFEDDSQFFEGL
The following text describes a protein:
Function:
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
Subcellular Localization:
Cytoplasm.
Sequence:
MESKKPLILVSNDDGVMAKGISELVKFLRPLGEIVVMAPDSPRSGSGSALTVTHPVHYQLVKREVGLTVYKCTGTPTDCIKLALGSVLDRKPDLIVGGINHGDNSAINVHYSGTMGVVIEGCLKGIPSIGFSLCNHRPDADFEPSGPYIRKIAAMILEKGLPPLTCLNVNFPDTPNLKGVKVCEQAKGCWVNEWVTCPRLDDHNYFWLTGSFTDHELENENNDHWALENGYVAITPTTVDMTAYGFIDELNGYCQQLEF
The following text describes a protein:
Function:
Specific subunit of the TRAPP II complex, a highly conserved vesicle tethering complex that is required for the proper transport of proteins in post-Golgi trafficking pathways to the growing cell plate in mitotic active cells.
Subcellular Localization:
Golgi apparatus, trans-Golgi network. Early endosome.
Sequence:
MEPGVSIESGSAIRVAVLPVGGPISPARLRDYAALVARHARVDLASLRPYYSEHQKSPFAHQPWGGGCLRLKFVLGGCVPSPWEDFQSSRKVLAVVGICHLPSSPDLGRVAADFVDAARSYPSALASRCFAFCPTDAQLVQKKRDNIIMFPPSDQQSLELHMLTMIQDLSASLLMEFEKWVLRAESTGTILKTPLDSQSSLGSEEVIKAKKRRLGRAQKIIGDYCLLAGSPADANAHYATAIELARLTGDVFWHAGALEGSVCALVVDRMAESDPVLEDEVKFRYYTIIQLYRRATLQDNAQRVSPVSFELEAALKLARYLCRRQCAKEVSDLLMGAADGAKALIDASDRLILYIEIARLFGTLGYKRKAAFFSRQVAQLYLQQDNAYAAMSAMQVLTTTTTAYHVQSRKTSKMDHGLLKSVVSLFESQWSTLQMVVLREILMSSIRAADPLSSWSAAARLLRSFYPLITPAGQSGLASSLSNSADKLPSGTRCADPCLPFIRLHSFPLHPSQREIVKRNPNKKEWWTGGGPSGPFIYTPFTKGGTSGTSKQEVNWIVGEPVQVMVELANPCSFDLIVESIYLSVHSGNFDAFPVSVNLPPNTSKLVLLSGIPTQVGQVSIPGCIVHCFGVITEHLFKEVDCLLLGAAQGLVLSDPFRCCGSSKFKSVNFPSISVVPPLPLLVANVVGGDGSILLYEGEIRDVLITLTNAGTVPVEEANVALSGKNQDSVISIAHSTWKSALPIKPGGEVTFAVTLRAWHLSPTDLEADGSRSPANSRRIAREGSNPFLDIHYAGPSGNSESNDVSLPPGRRLVVPLNICVVQGMRLVRARLLSMELPARFTDAHLRSVSSKDNLSNGSDAIRNDISLLKIDPYKGSWDLRLLELELFNPTDVVFDVDVSVHLDGTSVEQKILPEDKTASSACHKTRIDRDYSARVLIPLEHFKLPVLDTSFFVKENGSDEPLGSRAATLAEKNAKAELNASINNLISKIKVKWHSGRNSSGELNIKDAIQTALQASIMDILLPDPLTFSFRHAKDGTTAKTDSSKEPGDGSSRSADESVLRCKDPIFANEMTHMEVQIRNNTKETIRMNLSISCKDVAGENCFDENSATVLWAGVLSDIYLEVQPLQEVVHPFSIYFLVPGDYSLQAASVIIDATDVLRARAKAESPDEPILCRGSPFHIHVVGTA
The following text describes a protein:
Function:
Functions in the transition of mRNAs from translation to an mRNP complex destined for decapping. High-copy-number suppressor of decapping defects. Overexpression suppresses decapping defects in both DCP1-2 and DCP2-7 mutations. Acts to promote translational repression of mRNA in conjunction with DHH1 and subsequent mRNA localization to P bodies. Promotes translational repression of mRNA during glucose deprivation.
Miscellaneous:
MISCELLANEOUS: Present with 12800 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Cytoplasm, P-body. Cytoplasm, Stress granule.
Sequence:
MSAEIEEATNAVNNLSINDSEQQPRAPTHKTVIDPEDTIFIGNVAHECTEDDLKQLFVEEFGDEVSVEIPIKEHTDGHIPASKHALVKFPTKIDFDNIKENYDTKVVKDREIHIKRARTPGQMQRGGFRGRGGFRGRGGFRGGFRGGYRGGFRGRGNFRGRGGARGGFNGQKREKIPLDQMERSKDTLYINNVPFKATKEEVAEFFGTDADSISLPMRKMRDQHTGRIFTSDSANRGMAFVTFSGENVDIEAKAEEFKGKVFGDRELTVDVAVIRPENDEEEIEQETGSEEKQE
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
Subcellular Localization:
Nucleus.
Sequence:
MNDYLNLYVPSYDPYYNMEMNSKRVMMPSVSYWVYEKINSESPDYYSNKDPIYNEYRRKTGAIGFVKPPTSKYWKEYADSHNKPTLSHLEETHDDEDELDVFYSKNGIKMLPRVGATRQELIQYFGKAGEEAANELQMVDAPFIEGLRSVFDIVVDPDDEIVQSIKSNPKYPPVRPADNFPHHQTPKLISVPPYEGDLSEIDVDKMLIGEKNDDLGKSNVCNESLITEIFERKDEFAAFDAKQFNDARIKANPWETIGKVIFQNRAAMKMANLDAIFNFTNSPEFPNLAPNCGKLEDYFYFADICAGPGGFTDYLYWRLDGRAKGFGMTLAGDHDWAQPEMFLSTIPNFTKVYGPEGNGNIFNPDNIEDLYNTIKTETNNKMVQLVTADGGTAVDGEENAQEQLHKRLVLCQFLTALRVLRKGGSFLCKTFDVYTDFSVELLYLLAQCFNRFCIIKPYTSRPANSERYVVGLGLREEDPPARSLFSRLNESEVWKDTTKEPLSFFPFEKIPNEFIQYVKESNEYLVEYQDKACVNLLTYGYNPELKPLDQEDVKRRCLEEWKVPTTVNKKEVILKYQAWQPKEIKSTANVDAMFPLAQVQEKKYILEPPMQTRIDHNNKITYVSPMGEKIAEMRRGLYDESNYYEYITYKKARTAESLLNHDNEYDDDNNNRGQLNGTENKPKSVVVFAN
The following text describes a protein:
Function:
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Sequence:
MLKECIKIEGRAFLGGKVTRVKLGSGECKTLQLSNKYLILPGMVDIHVHFRDWGLSHKETLRGGAAAALAGGVVAVGDMPNTKPHIRTADLYKKRLEEGSALPIIYKVHMGIPQDLEELRAARPPTIKIYPEDVEAFGWGHIEKAAEACASLGCRLVLHCEDPAYFKEGERPPIAELACVERTRQMAFKTGVKIHLTHITLSQTAEAARGWATVDATPHHLLLDVENCKDSGLCHVNPRLRTPEMRKRLLAAFASGLVDIYATDHAPHTLEEKRSGAPPPGICSLDVALSLLLTLWKRGVVTLSDVVRLYSHRPARFFDLQIDVKKGYFTVVRLEEFTVRGEEFAGTCKHTPFEGFKAFGRVFATSVGGRIYFKDGDVYMINI