lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan.
Subcellular Localization:
Secreted.
Sequence:
MWLNSGVTSGGDTPASKPSFGLAASAQVPAMYPRLKTCEWSSYLKYPARIVSAGGPTSAPFSPWLLAMYPLFSSLLCFASLNVLPFSVLAGASERGPPLPSTHISLSSFKWSLVNANRSIVVPTPFLNQPHLALIKAGVIDDPNIGLNEGTTRWVGEEEAWTWETKFKVDLNDGWAKAERFYLVFNGLDTFCDIQVNGHRIGSTDNAFRSWVFDATQVIKSSLNQTVPLSLRFASAYATASKLAHEPGNMWFPNKSADKKNSTTLQPFEYNYRNWARKQQSDFGWDWGPAYLPSGPIKPAYLIGLSASAQSKFELVDQRKSHQPQTRIVHEPSSIAPVKTRKELSLPTDKKRKRATGGTKSAPSLWVHRTIIDVYRIGQRNNLSPDQGAPWVLNITLPITSPKLVNATLSGVLSGTSVKLPAKRLTTLKTPPYRNFGPDYSLTVEYIIDPKQVELWYPATLGTPTLYDLELTLQADGQESGELAWSEKVGFRTIVVDQSRYTDQEVSNGIRPGTRFTFVINGKPFYVQGSSMIPIDNFAARANSTTIRWLLESALLANQNVVRIWGGGAYQTDEFYDICDELGILAWSESVFACGAYPLSPDSFLDNIRAEVSENVARLNRHPSTALWAGNNEGEGYLIDVNRTWTNGSIYFNQYDHLNNHVLRELVLDNTRSISYIPSSTTQGYLSLDPYVARYYNSTSGELYGDKEHYNYDTTASFNISSYPVGRFVNEFGFHSMPSIYTWDRVLKSPQDYDFNSTVIRAHNKHNPAESLAYPWPADDGQMQMTTGVTDHYPTPSITGDYHTQLAQWAYSTQVFQAAFMASEINYYRLGASRGENNMGAVYWQLNDVWEGISWSSIEYTGRWKIFHYIAARVQSHVIISPIFHQTNNTLDIYVTSDLWQPVEGTAQWTWYDFAGQKLSDTTTKSFSVAPIHSTQLYHAGGLSEMVPNGHPPNDAWMHLTMTTSDGKYTNEQFFHPVALKDCQLRPTKVQSQPIGHNQVSIQVAGGGVAVWVNVEHPPGVRGYFKDMKTGLPSNAFFLRPKETRQLEFVLKGKDSDHEGLAKNLASRMVVRTLWDNQHRSQ
The following text describes a protein:
Function:
Required for chromosome synapsis and normal fidelity of crossing over.
Subcellular Localization:
Nucleus.
Sequence:
MQKLGFPAMKSFDQLRSLPGSAKTYFFSTRPPQDSVSSGSFSNLKLTAEKLVKDQAAMRTDLELANCKLKKSMEHVYALEEKLQSAFNENAKLRVRQKEDEKLWRGLESKFSSTKTLCDQLTETLQHLASQVQDAEKDKGFFETKFNTSSEAINSLNQQMRDMSLRLDAAKEEITSRDKELEELKLEKQHKEMFYQTERCGTASLIEKKDAVITELETTAAERKLKIEKLNSQLEKLHLELTTKEDEVIHLVSIQEKLEKEKTNVQLSSDELFEKLVRSEQEVKKLDELVHYLIAELTELDKKNLTFKEKFDKLSGLYDTHFMLLRKDRDLASDRAQRSFDQLQGELFRVAAEKEALESSGNELSEKIVELQNDKESLISQLSGVRCSASQTIDKLEFEAKGLVLKNAETESVISKLKEEIDTLLESVRTSEDKKKELSIKLSSLEIESKDKYEKLQADAQRQVGELETLQKESESHQLQADLLAKEVNQLQTIIEEKGHLILQCNENEKNINQQIIKDKELLATAETKLAEAKKQYDLMLESKQLELSRHLKELSQRNDQAINEIRRKYDVEKHEIINSEKDKVEKIIKELSTKYDKGLSDCKEESKRQLLTIQEEHSSRILNIREEHESKELNLKAKYDQELRQNQIQAENELKERITALKSEHDAQLKAFKCQYEDDCKKLQEELDLQRKKEERQRALVQLQWKVMSDNPPEEQEVNSNKDYSHSSVKVKESRLGGNKRSEHITESPFVKAKVTSVSNILKEATNPKHHSKVTHREYEVETNNGRIPKRRKTRQTTMFQEPQRRSTRLTPKLMTPTIIAKETAMADHPHSANIGDLFSEGSLNPYADDPYAFD
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MAMSSYLINSNYVDPKFPPCEEYSQSDYLPSHSPDYYSSQRQEPGAFQPDSLYHPHQHQNHRPRAEPPYTPCQRAAQPASVLIPPRGHVALSTGQEQTTTFSDQSHRCNSVTPSPPPPPSCGQTAHGQGASSPASTRKDPVVYPWMKKVHVNIAPHWRPSWPERRGGRRSRDRRKGRRLGRHLRTHPHPNPPPSVTQIIPSHARIHARTHLPIQTIFSVPQVSHHQKQKLCPLCGKNFNETPAQQRRSGGQDDDAPHSGPVPRCQEETPPRATRQKLCAC
The following text describes a protein:
Function:
Binds to the 23S rRNA.
Sequence:
MTDKKRRQRGSRTHGGGTHKNRRGAGNRGGRGRAGRKKHEQHNYEDVGKSGFKRPEKTDRDVAVLSVQELDEDIPVLSESGVAEETEFGYRVDARDVVDDGWDADVVKVLGGGQLYEQLEVTADAFSDAAVELIEGEGGDAVVSERASEDDEE
The following text describes a protein:
Function:
May play an important role in inflammation and regeneration of skeletal muscle. Essential for embryonic development (By similarity); [Isoform 1]: Has chemotactic response in monocytes, neutrophils and lymphocytes. Binds CCR4.
Subcellular Localization:
[Isoform 1]: Secreted; [Isoform 2]: Membrane; Multi-pass membrane protein; [Isoform 4]: Membrane; Multi-pass membrane protein.
Sequence:
MDNVQPKIKHRPFCFSVKGHVKMLRLALTVTSMTFFIIAQAPEPYIVITGFEVTVILFFILLYVLRLDRLMKWLFWPLLDIINSLVTTVFMLIVSVLALIPETTTLTVGGGVFALVTAVCCLADGALIYRKLLFNPSGPYQKKPVHEKKEVL
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MKHQYSKQQDSQDYEQMRGIEDFKDLVLRVQKWGGDQGLAKQLKSNQQKGIDSEAQVIENREKYGNNDPIEKESESLCDLILECFGDTMLQILLLAAFVSTIIGMVNEGVATGWTEGATIFFAVFLIVSITAGNNYLKERQFQQLRRRLDEGIVQVVRGGIVEISIKDIVVGDVLQFGIGDMFAVDGLMIQGSSVKVDESAMTGESDEIKKLPFSEMIQQSKLPLDSHHCSPFLISGTKCLDGNGYMLVLQVGQNTVQGQLKLLLNQDNPPTPLQQKLEGVAEDIGKLGTLVAILTFIALMGHLIYDVFVLHKHDFLTLKTFSFIIDAFMIGVTIIVVAVPEGLPLAVTIALAYSVGKMKDEQNLVKNLASCETMGGANNICSDKTGTLTQNVMSVTTIWSENSFILKDQLTSNNNLLSKQTVEIMAESICYNSNANPTKDKNSNRWIQIGNKTECALIELADLFGFKYANYRQNDKILRQIPFSSKRKKMSTAVLNQKNQTVRIFTKGASEIILAQCFKYVSKGGNEMLLDKAKKDDILHNVIEQYASQCLRTIAIAYRDFEPQSSSFKGSTVNMKAHIHQIPEDDLDKDLTLIAICGIKDPIRADVPNAIKLCNQSGVVVRMVTGDNIITAQSIAKECGILEQGRAQQEFEVIEGKKFRELVGGLMTVKDDEGKEIKKIKNMQIFSKISREMRVMARASPEDKYLLVTGLIEEGNVVAVTGDGTNDAPALKKADVGFAMGITGSDVAKDAADIILIDDNFNSILTAMIWGRNIYDCIRKFIQFQLTVNLVALFMSFTGAVILKQSPLNAIEMLWVNLIMDTFASLALATEPPSITVLSRLPYRRTDQIVSPTMYRTIVGASVYQITILSFILFLLPNYVDCSMPPELYPSNVVQMSIFFQAFVLMQVFNSISCRQLDYHTKNPFSNFCNNPLFWIVQTITVIVQILLIQYGGRYVKVSHLTSSQHLLCFGFGVFGIVFSLLFKFIPESICQKIHLFREDEIKTDKMDDTLTSRLRRKSTMRLHTSQRSKVEGGSLQKMSSQKI
The following text describes a protein:
Function:
Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate: de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.
Sequence:
MEAQNAQRRSYQVVIAATRDMGIGIDMKLPWDLPNEFQFFQDVTSRTSDPRKRNATIMGRKSWEATPLEFRPLPDRLNVVLTRSNCHSIPTDDDNVMVCGSMESALELLAKPPYSFSIEKVFFIGGGELLRHYMNAPSCDAIHLTEVDITVPCDTFAPRVDTCLYHPWYSSLPVVENGIRYCFNTYVRRKDLIFGSGVEAEQYSFLPKMVFERHEEFGYLNLVQNIISNGDMNDNNTLLSKFGCQKVFWVGVVEEILQLISGSTYPKEKGINHIWESDKAKEYLDSFGVNATEEDGDHPLLTGLYWSYSDASQEFNQISDVINKIKNNPHDRGITLSACKLSISPCQTFAQFYVANGELSCQIYQSSTEASLGIPFSIAAYSLLTCIMAHVCDVVAGDFIHLIGDAHVNTSHTKAIQRQLQISPKPFPILKINPAKKKIDHLEASDLDLLDI
The following text describes a protein:
Function:
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKTSYVCIHCGEGQQQLYKRYGPDLLKLSRCSKCNHTVDEYIEMELSIVFIDAVLQKLEAYRHLIFNVGVERPWKLAVFFLLGEALELWMSRQQGAGAGLGLEWHFYLTCLFLVASNAVFLALVVALVNLCVKTCNREHLAWALVLCSYGKLLALPATLWGCDRSQAHFLVTAFFLCSQVQACRVVSGAGRSWAAAVVATSYLVQQAAVVWASPILRLSDYAGPQETD
The following text describes a protein:
Function:
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
Sequence:
MSMTKSKLRVYDDTRAMFHLPDGVIYLDGNSLGALPLGVAERVSRVITTEWGDELIRAWNTAGWYAQPRHVGDRIARLIGAEAGSVMVGDTLSLKVYQALAAALDMSASRKVVLSDTGNFPTDLYMAEGLIATLGRGHQLRLVAPEEIEAALSEEIAVLYVTEVDYRTGRRHDMAKLTAKAHALGIVTVWDLAHSAGALPVDLAGSGADFAAGCTYKYINAGPGAPAFLYVAPRHADSARAALSGWMGHAKPFAFELAYVAAGGIERMRVGTPPVLAMAALEASLDIWDRVDIAEVRARSLALGDLLIAEVGRRCPSLELVTPRAHERRGSQVSFAFDGGYAAMQALIARGVIGDFRAPDIMRFGITPLYIGESEVMRAAEIIEEVIAGEVWRRPEYQVVNAVT
The following text describes a protein:
Function:
May play a role in ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MSGDSRPAQYKQSSRKGKKAWRKNIDLTEIEQSIDSRIEHEITHGAENLADVPSQNLFEVDTTGDELLKAKLIKRKQIKKNIKSKEILDSIKSNSKVPALLHPKSHVNEKAKVQGVSKKELNRLMTLAGRNMESKLKAQVTKEGLVKAGTNDLWGSEEPLKTPSGDFDLKLKDKVPEPLLKQSTTSWSRATVAPETLKHAPLRVKDTEELPHAGKSYNPDKKQWEALIEKEYKIESANEERRQQMAEYKKKIQHLMETLDDREEESDEDAPQSEEELASVDEDGDFRLSLNPAVKNKKKTKYQRNRQKRHQEKVKLQQELKTLKEQLHQLEKLEAIEQAVAAKTAQEASTLIPAKVKNNKKHKLGTKHSVMEDNLEVKFSDELSGSLRSLRPEGNLLYDSLRKLQGSGKIETRVPIRKGRKYKQKITEKWTYKDFK
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Sequence:
MFSMLHPLDEITPLVCKSGSLFGSSRVQYVVDHAMKIVFLNTEPSIIMTYDTVQSLHSVWALRRVKTEEENVVLKFSEQGGTPQNVASSSSLTAHLRSLSKGDSPVASPFQNYSSIHSQSRSTSSPSLHSRSPSISNMAALSRAHSPALGVHSFSGVQRFNLSSHNQSPKRHSISHSPNSSNGSFLAPETEPIVPELCIDHLWTETITNIREKNSQASKVFITSDLCGQKFLCFLIDTMLVLEGSGNLVLYTGVVRVGKVFIPGLPAPSLTMSNTMPRPSTPLDSVSTPKPLSKLLGSLDEVVLFSPVPELRDSSKLHDSLYNEDCTFQQLGTYIHSIRDPVCNRVTLELSNGSMVRITIPEIATSELVQTCLQAIKFILPKEIAVQMLVKWYSVHSAPGGPSYHSEWNLFVTCLMNMMGYNTDRLAWTRNFDFEGSLSPVIAPKKARPSETGSDDDWEYLLNSDYHQNVESHLLNRSLCLSPLEVSQMKDEDFSQNLILDSSTLLFTHIPAIFFVLHLIYEELKLNTLMGEGIRSLVGLLVQLARDLKLEPYVDHYYRDFPTLVRTTGQVCTIDQGQTGFMHHPSFFTPEPPSIYQWVSSCLKGEGMPPYPYLPGICERSRLVVLVFRIIGTVAGFTLRDLETLPFGIALPIRDAIYHCREQPASDWPEAVCLLIGRQDLSKQACEGNLPKGKSVLSSDVPSGTETEEEDDGMNDMNQEVMSLIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELSDHEFIEEKENRLLQLCQRTMALPVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMTSWASFHNGVAAGLKIAPASQIDSAWIVYNKPKHAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKGHEMTSIGLLLGVSAAKLGTMDMSITRLLSIHIPALLPPTSTELDVPHNVQVAAVVGIGLVYQGTAHRHTAEVLLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLNVPEQLYQYMVGGHRRFQAGMHREKHKSPSYQIKEGDTINVDVTCPGATLALAMIYLKTNNRSIADWLRAPDTMYLLDFVKPEFLLLRTLARCLILWDDILPNSKWVDSNVPQIIRENSISLSEIELPCSEDLNLETLSQAHVYIIAGACLSLGFRFAGSENLSAFNCLHKFAKDFMTYLSAPNDSVTGPYNLETCLSVVLLSLAMVMAGSGNLKVLQLCRFLHMKTGGEMNYGFHLAHHMALGLLFLGGGRLPWFCSLCHQESLCCSLLCIYKHIPCLGRIQYHLQALRHLYVLAAEPRLLVPVDVDTNMPCYALLEVTYKGTQWYEQTKEELMAPTLLPELHLLKQIKVKGPRYWELLIDLSKGTQHLKSILSKDGVLYVKLRAGQLSYKEDPMGWQSLLAQTVANRNSEARAFKPETISAFTSDPALLSFAEYFCKPTVNMGQKQEILDLFSSVLYECVTQETPEMLPAYIAMDQAMRRLGRREMSETSELWQIKLVLEFFSSRSHQERLQNHPKRGLFMNSEFLPVVKCTIDNTLDQWLQAGGDVCVHAYLSGQPFEESQLSMLACFLVYHSVPAPWHLPSIGLEGSTSFAELLFKFKQLKMPVRALLRLAPLLLGNPQPMVM
The following text describes a protein:
Function:
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
Miscellaneous:
MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSSYISLLKPRVIWLLILASVAGYIYGGGGVDSRLFSLLAVAFLSTGGSAAFNHYWERDIDALMTRTFKRPLPSGLITPNAALAYSLALSATGISLGFLLLGLLPGLFVLLGWLFYAVVYTIVLKRRTWLNIFGGGFAGNAVFLGGYALAKGTVDLPAVLISFAIYLWIPSHIWALAFKYRGDYKRAGVPMLPALIKEERAVAVISAINAAAAAYILWLYLQFGGGAGGALVALGVAATIATSIYAAVKKTEEAMWKMYKASSPILALFLIALILSRL
The following text describes a protein:
Function:
Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
Subcellular Localization:
Cytoplasm. Note=Colocalizes with RAB11A on cytoplasmic vesicle membranes.
Domain:
The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.
Sequence:
METILIKNTGQQENEQLKEEEEEEVDPRIQGELEKLNQSTDDINRREIELEDARQKFRSVLTEATLKLDEMVKKIGKAVEDSKPYWEARKVARQAQLEAQKATQDFQRATEVLRAAKETISLAEQRLLEDDKRQFDSAWQEMLNHATQRVMEEEQKKTRSELLHKETAAKYNAAMGRMKQLEKKLKRTINKSKPYFELKAKYYLQLEQLKKTVDDLQAKLSLAKGEYKTALKNLEMISDEIHEKRRTSSMGPRGRGVGSEGNNSLEDLSACKLDSDNISMTSEVFDDDNLSSLVSEEDSETQSMSSFSSVPTSPAEIPSPFPNVPRPGSLDLSSPLSLSDFGLISPILGPRSECSGASSPECDLERGNRAEGSENAAQDRINNNSKSNSRKAMALPVLDNKIKQITLECTKTGNGTNTERKKCSRSQSLASTLLVNAV
The following text describes a protein:
Function:
Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes. During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung. Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage. To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Down-regulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex. In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC1. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites; [Isoform 3]: Can act as dominant-negative. Binds DNA and have transctivation activity, even if much less efficiently than isoform 2. Does not inhibit cell proliferation; [Isoform 4]: Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation.
Subcellular Localization:
Nucleus; [Isoform 4]: Nucleus, nucleolus.
Domain:
The recognition sequence (54-72) is required for interaction with TRIB1.
Sequence:
MESADFYEVEPRPPMSSHLQSPPHAPSNAAFGFPRGAGPAPPPAPPAAPEPLGGICEHETSIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAAGPAGGGGDFDYPGAPAGPGGAVMSAGAHGPPPGYGCAAAGYLDGRLEPLYERVGAPALRPLVIKQEPREEDEAKQLALAGLFPYQPPPPPPPPHPHASPAHLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPHAAPALGAAGLPGPGSALKGLAGAHPDLRTGGGGGGSGAGAGKAKKSVDKNSNEYRVRRERNNIAVRKSRDKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPESSLVKAMGNCA
The following text describes a protein:
Function:
Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.
Sequence:
MAVFRSLSEVATPCAVALGNFDGVHLGHQAVIQAVLGRAGIPTVLTFDPHPREYFTGKTGFLLAPERERTAAILALGIAQVLVLPFDELLAATEAGAFVEQVLVAGLGARFVSVGWNFRFGKERAGTTEMLQSYARAGAFDIEILAERQVRGRRVSSSVIREALGCGDLDLARLLLGRAYGLEGEVVRGDQRGRLLGFPTANLQVSGRKFLPKDGVYLVSARWGVQQRWGLLNLGLRPTFDGLKRTIEVHVLDWEGDLYGQHIKITLERYLRPEQKFGSPGELVAQLHRDREAALKEIAGNP
The following text describes a protein:
Function:
GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with sdo1, may trigger the GTP-dependent release of tif6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating tif6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Inhibits GTPase activity of ribosome-bound EF-2 (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MPVIPPEKLVSLQKNQENIRNFTLLAHVDHGKTTLADSLLASNGIISSKLAGTVRFLDFREDEITRGITMKSSAISLFFKVISQNDEKRVEKDYLINLIDSPGHVDFSSEVSSASRLCDGAFVLVDAVEGVCSQTITVLRQAWIDRIKVILVINKMDRLITELKLSPIEAHYHLLRLVEQVNAVIGTFYTGELMQLADNDEVISDEGIYFAPEQGNVVFASAYDGWAFCLDQFSEFYEKKLGLKQKALTKCLWGDYYLDPKTKRVLQPKHLQGRRLKPMFVQFVLENLWAVYESAVSNRNLENIEKIIKALNIKVLPRDIKSKDPRNLLLAIFQQWLPLSTAILLTAIREIPSPINAQANRARKVLSSTPHYEMIDPDITLAMESCDASKEQPVLVYISKMVAFSERDLPNHRRKQLSAEEMKLIRSKLSESIESGINTISIEENVSSTNSDNLEGSTTDMDDDKDILIGFARIYSGTISVGQEVYVYGPKYDPVNPEKHITKVTVESLYLMMGQELVYLETVPAGNVFAIGGLAGTVLRTATLCSSPNGPNLVGVTQQMEPIVRVALEPVRPFEMNKLVTGLDMLNQADPCVQIAVEENGEHVIMCAGEIHLERCLKDLRERFAKIEIQASQPLVPYRETTIATPDLLAKNKELSIGFVTATLPVGGVTIGITVTPLSGSVVDFLLKHSKTIENVSSNFSKKNRNVVVSESLTKSMEEVLTPEKFYERLSKLLEEENSDLGELKNHLDSIIAFGPKRVGPNILFDKTKKMRDFRRQSDETKLIPSDLSEYVVTAFQLITHQGPLCAEPVQGICVSIDQFDISDDSEDSKLLTINNPQIPGQVISVVKESIRHGFLGWSPRLMLAMYSCDVQATSEVLGRVYGVVSKRRGRVIDEEMKEGTPFFIVKALIPVVESFGFAVEILKRTSGAAYPQLIFHGFEMLDENPFWVPTTEEELEDLGELADRENIAKRYMLNVRKRKGLLVEQKIVEKAEKQRTLKH
The following text describes a protein:
Function:
Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells.
Sequence:
MATSNVRVVLRIRPFIPSEIDDRSNGTPESCVTVVDNDEFNTLDGGEVTVQIKDRLSSRKECYKLDSIYNQENDLLPIFQQEVTKIIPEIFQGSNGTVFTYGATGSGKTYTMQGTDEHPGLIALALSSIFSTSKIAGGSVEISYYEVYLDRCYDLLEPKAKEIMVLEDKDGIIQFKGLSKISVGSMEEFDQIFSCGVQRREVAQTGLNDVSSRSHGILSIFVSTKIKSTDALVTGKLNLIDLAGYEENRRTYNEVIRLQESAKINQSLFALSNVIYALNNNEVRVPYRESKLTRILQDSLGGPNQSLLIACLNPVSYSEAIHTVGLAARSRHVVIHSKCLEKMETPRIKVDMEEKLRVWIESKGKCKSTHKIFSSCGVLGKTPNPKSKTCQKRTDAARSNKITTTNNHFVSRKLFDAPVVELEEEKKFDREAKQSSSSIQNVLSSLNVNTTPIKKNIISDKEEICCDNTPLNKFTALGSTLKKSLENEYLEVLNIASKEELLSLKGIGPKRAENIIALRIDSSPPFKTISDLEKIGLSTKQVKDIFVRAAKEIFA
The following text describes a protein:
Function:
Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.
Sequence:
MEGHKTLPSRVPSAVRSVRPLQAQNGPVAGGSSKTKVASKPDRRGPTAIANSERALRAENETLHTDLTKLRAELAGVQAHAQKLEVELQQLRNEREAYRSSLETDFAKKSADLLANFQAQQDQLQSETAAKQKADAQELIELKHTHRLLLEQLDKNGWNPVTGAPNAESSMLSSEQAVQAQTLVQGLHKAVGDFAARQAALNAALTSALATSAQSEPSALSEHAAELSQDEQVATRSYHVCVCVCVCVCVCVCVCVCVCVCVCVCVCETWRNGARMAASLWPQVLLVCMAGARTTTLRLVSAGLGSVLKSVMAARPAALARPIVRRALHSGAVQRAVRQPQSEPLFEIQHQSQSPGDSHVQCTTLSNGIRVVTEQIPGVWANVTAVFGFGSQDETAATRGASYFLDRMAFKGSAHISAEQMMATMERVGGDILVQTNRETTLYSANVLQNNIEDVLELMAHNMLVPAYSEADFNACMDGLVYAEELALDAPGVECLERLHEAAYGHQSIGKPLRPTFMEAQSLTPDKLRQHQQTNLHPSHCVIAGVGVNHDKLVELVTKYLGPNVLPPSTNPTSRQPPKFIGGDCIMQTDKPLLHPALQTDQTHIALGFETPHWADMAQAIPYAVVQGVLGGGSAFSSGGPGKGLHSWFYTHLLNNYYWVETATAGLVPYMDTGLMALQFACEPTRTSMTIQLALRILHLVHSGITEADLERAKNLIKSQLLLNLESRAVRAEDIARQYLAGDVYYDSRQLCELLDNTTLADVKEAVKKMMTSNVAVAALGSNVRDCPTAANIQRHIDQTYRFE
The following text describes a protein:
Function:
H(+)-stimulated, divalent metal cation uptake system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLNGRAVDTSRRPLRKIKLSLMGPAFIAAIAYIDPGNFATNIQAGATFGYTLLWVVVWANVMAMLVQLLSAKLGIATGKNLAEHIRDRFPRPVVWAYWVQAEIIVMATDLAEFIGAAIGFKLLFGVTLLQGAVLTGIATFLILMLQNRGQKPLELVIGGLLLFVAAAYIVELIFSQPDIAALGRGMLIPNLPDGNAVFLAAGVLGATIMPHVIYLHSALTQTGGEESKTERYASTKFDVAIAMTIAGFVNLAMMATAAAAFHFNGYENIAEIEEAYITLQPLLGNAAATVFGLSLIAAGLSSTVVGTLAGQVVMQGFVRFYIPMWVRRIVTMLPSFIVILAGMDATQILVMSQVLLSFGIALALVPLLVFTGNKELMGELVDTKTTQILGKLVVLIVVGLNAYLLISLL
The following text describes a protein:
Function:
Probably part of an ABC transporter complex involved in carbohydrate transport.
Subcellular Localization:
Cell surface.
Sequence:
MKNWKKYAFASASVVALAAGLAACGNLTGNSKKAADSGDKPVIKMYQIGDKPDNLDELLANANKIIEEKVGAKLDIQYLGWGDYGKKMSVITSSGENYDIAFADNYIVNAQKGAYADLTELYKKEGKDLYKALDPAYIKGNTVNGKIYAVPVAANVASSQNFAFNGTLLAKYGIDISGVTSYETLEPVLKQIKEKAPDVVPFAIGKVFIPSDNFDYPVANGLPFVIDLEGDTTKVVNRYEVPRFKEHLKTLHKFYEAGYIPKDVATSDTSFDLQQDTWFVREETVGPADYGNSLLSRVANKDIQIKPITNFIKKNQTTQVANFVISNNSKNKEKSMEILNLLNTNPELLNGLVYGPEGKNWEKIEGKENRVRVLDGYKGNTHMGGWNTGNNWILYINENVTDQQIENSKKELAEAKESPALGFIFNTDNVKSEISAIANTMQQFDTAINTGTVDPDKAIPELMEKLKSEGAYEKVLNEMQKQYDEFLKNKK
The following text describes a protein:
Function:
Together with ABCG40, import into the embryo the abscisic acid (ABA) delivered from the endosperm via ABCG25 and ABCG31-mediated export to suppress radicle extension and subsequent embryonic growth. Involved in root secretion of phytochemicals (phenolics and sugars) which regulate soil microbiota, influencing both fungal and bacterial communities. May be a general defense protein (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIQTGEEDEEKATSLEVEFASGNGVDDEEELRLQWATVERLPTFKRVTTALLARDEVSGKGRVIDVTRLEGAERRLLIEMLVKQIEDDNLRLLRKIRKRIDKVGIELPTVEVRFNNLSVEAECQVIHGKPIPTLWNTIKGLLSEFICSKKETKIGILKGVSGIVRPGRMTLLLGPPGCGKTTLLQALSGKFSDSVKVGGEVCYNGCSLSEFIPEKTSSYISQNDLHIPELSVRETLDFSACCQGIGSRMEIMKEISRMEKLQEIIPDPAVDAYMKATSVEGLKNNLQTDYILKILGLDICADTRVGDATRPGISGGEKRRLTTGELVVGPATTLFMDEISNGLDSSTTFQIVSCLQQLAHIAEATILISLLQPAPETFELFDDVILMGEGKIIYHAPRADICRFFEEFGFKCPERKGVADFLQEIMSKKDQEQYWCHRDKPYSYISVDSFINKFKESNLGLLLKEELSKPFNKSQTRKDGLCYKKYSLGKWEMLKACSRREFLLMKRNSFIYLFKSALLVFNALVTMTVFLQVGATTDSLHGNYLMGSLFTALFRLLADGLPELTLTISRLGVFCKQKDLYFYPAWAYAIPSIILKIPLSVLDSFIWTLLTYYVIGYSPEVKRFFLQFLILSTFNLSCVSMFRAIAAIFRTIIASTITGAISILVLSLFGGFVIPKSSMPAWLGWGFWLSPLSYAEIGLTANEFFSPRWSKVISSKTTAGEQMLDIRGLNFGRHSYWTAFGALVGFVLFFNALYVLALTYQNNPQRSRAIISHEKYSRPIEEDFKPCPKITSRAKTGKIILPFKPLTVTFQNVQYYIETPQGKTRQLLSDITGALKPGVLTSLMGVSGAGKTTLLDVLSGRKTRGIIKGEIKVGGYPKVQETFARVSGYCEQFDIHSPNITVEESLKYSAWLRLPYNIDSKTKNELVKEVLETVELDDIKDSVVGLPGISGLSIEQRKRLTIAVELVANPSIIFMDEPTTGLDARAAAIVMRAVKNVAETGRTVVCTIHQPSIDIFETFDELILMKNGGQLVYYGPPGQNSSKVIEYFESFSGLPKIQKNCNPATWILDITSKSAEEKLGIDFSQSYKDSTLYKQNKMVVEQLSSASLGSEALRFPSQFSQTAWVQLKACLWKQHYSYWRNPSHNITRIVFILLDSTLCGLLFWQKAEDINNQQDLISIFGSMYTLVVFPGMNNCAAVINFIAAERNVFYRERFARMYSSWAYSFSQVLIEVPYSLLQSLLCTIIVYPTIGYHMSVYKMFWSLYSIFCSLLIFNYSGMLMVALTPNIHMAVTLRSSFFSMLNLFAGFVIPKQKIPKWWIWMYYLSPTSWVLEGLLSSQYGDVDKEILVFGEKKRVSAFLEDYFGYKHESLAVVAFVLIAYPIIVATLFAFFMSKLSFQKK
The following text describes a protein:
Function:
Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (By similarity). Essential for reproduction. In female gametophyte, is necessary for the egg cell and central cell fate determination and hence reproductive success. Involved in a mechanism that prevents accessory cells from adopting gametic cell fate. Modulates egg cell signaling center that regulates the development of all female gametophytic cells.
Subcellular Localization:
Nucleus speckle. Note=Colocalizes with CLO.
Sequence:
MEPNKDDNVSLAATAQISAPPVLQDASSLPGFSAIPPVVPPSFPPPMAPIPMMPHPPVARPPTFRPPVSQNGGVKTSDSDSESDDEHIEISEESKQVRERQEKALQDLLVKRRAAAMAVPTNDKAVRDRLRRLGEPITLFGEQEMERRARLTQLLTRYDINGQLDKLVKDHEEDVTPKEEVDDEVLEYPFFTEGPKELREARIEIAKFSVKRAAVRIQRAKRRRDDPDEDMDAETKWALKHAKHMALDCSNFGDDRPLTGCSFSRDGKILATCSLSGVTKLWEMPQVTNTIAVLKDHKERATDVVFSPVDDCLATASADRTAKLWKTDGTLLQTFEGHLDRLARVAFHPSGKYLGTTSYDKTWRLWDINTGAELLLQEGHSRSVYGIAFQQDGALAASCGLDSLARVWDLRTGRSILVFQGHIKPVFSVNFSPNGYHLASGGEDNQCRIWDLRMRKSLYIIPAHANLVSQVKYEPQEGYFLATASYDMKVNIWSGRDFSLVKSLAGHESKVASLDITADSSCIATVSHDRTIKLWTSSGNDDEDEEKETMDIDL