lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1. Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.
Subcellular Localization:
Cytoplasm, cytosol. Lysosome membrane; Peripheral membrane protein.
Sequence:
MAKQGGKESTTLKDKVKQLFRPKPSRVVTSGIHGKDTREEITCTPELLKEIGPESPLTNRLKALREFGDVVASRLLEDNAVEALWLNISDLLDPQASAEARHVALRFVQSLILGQYDRLGIMRAHFFRVVRHHQVFEDIPERLEVFKALSDNGKDITNFEEETGPFLLEWMPDAVSYGRTFEFMTLMVNVIKFNSSFLDEEIVAGLVRHTCNVCNQANSEEEIEASLRVLDAVVCYSCLPSESLYQFITTLCRTINVDKFCQTSWKLMRNLLGTHLGHSSIYTMCTILQDSHNRSDHQLLRGAVFYVGMSLWGAGRVNSLRLTPTSVLPSFLQALSSNNTIVAYEVVLIIHRLIKKYGKDLQQVTWEILTDILEALLKYIQTSPGASESLLLNFHAVLSTVEFLHENKCFNGSSERLFGIIEKFANKRPESSVLLLVSYRAQSIHPAKDSWILNLQNLMDKYFRYELRTPIRIKVLDVLSAVLSSTRHLYEENLIEGVVIPQLGQIADDPDVEVRNVAVQLLMDLAQTCNTERCLDILAIIEKVISRPMDTKKPLPTTPEGAPEAKPAAVDDSQLADIQTAVRGLIELFQTKLYRLPSAHACQVYYMLIGHVQSHYQHHYTAHTACQIRLEVFTCLLHLRADPLHRLGLPDKDGNYKFTAYITCDMKDSGSGRSSRATSPPTSHKAKSPTPGYTLKMSSLPFCKAVSAVLKCLGNETEWEVLKLVLQKLTEALQNKALILSGHVSNVEELCSKLCTMIALLSRQCLQVGQRTILEKLQHTPKEFPRSEFQSHMYPVLTALATYHAHLDQARQRELVRCLESGLVSKCAQQCVCALTVCSLEMRDVMMRMLPSVLLRLSQISATVAMAIPVLEFLSGLIRLPHLYANFVEEQYMSIFAIALPYTNPFKFSQYIVAMAHHVIAMWFIRCRLPFRRSFVQYITKGLKSNVPIEDRSASSPSSHHSPVSSTQDQFRTRSASFTERPRSFRPSPKSKFELLQLERSFTWRETRQSDHTPAMDERQETLLKVHTELLETCLDMMARYTFSTCSTIPKRSPVAEFLLAGGQTMTWLLGNQLITVTTSGGGLKMRKNGVCEKCASLLNLEDDKPTEDKSDHPSMNAPVTAEEYVEAEFRERSDSASKGTQEAPGKLETLTTSPSIPPAGNKRERKRSKSGGKYLSSAPTPMSLLKEEFQLFSQGLTEKAQMDVDEKATIQEDRSGEEREEVLEAEERELEEETRMDRTPEDSPSVTAGQVGRRAEMLQDVPKEQPSPAINPKAKNSPTKLVSRYECNCWCQGWAEILIRRPTGNTSWMMRIQNARLVQPDQDFPLADIATLLLGQKEEGLGSIPTLPAYGVKVGYCCLLAVLLSDTVCPTEKYSAASRYHRSDSAPPSMGVKQDRASKPIHETVSEVVHVDAGEDEETHEEDKGLFHIGSLEDVQSTETIGFQKPILGTSPVETLDVVEPPKGEDENQEEVVLDKSPLSPIRKTNSSPQLTGDWAVYQDKEEERMEELDNVFQSQDDDDDDERKNQNVPDDKNNSTLTVKHVPKAVVEPTQPVGKESDTCEGGTSNVSLKRVDSKERQERQVERKESTERQGKIGERKESTERQGKIGERKESTEKQGRSMERKDSQEKQKSAERKDSKSRQSGGWAGSRIMEDVKETGPPPSMETPTTPQASPPMMRRPRAQTVSVMTPGVNRREEFLERKRRMQPPVKEGTGSGVSPSFVFLQLFHSAAFGSVNEKPILLPKSEAVGRAVKNLDRIPPYETHKCGVLYVGPGQTTDEKAILCNEFGSLRYVEFLSGLGNLIYLKDCNPDEVFLGGLDCNGNDGKFTYSWQDDAMQMIFHVATLMPYRETDRNCQSKKLHIGNDFVTIVYNDNTEDYKPDTIKGQFNFVNIVIMPLDNSSNLVTIKAKKEVENMVGDTSSKIISDDNLALTVRQLALHANLASMIHRSKNSPEGVYASKWLERLRQIKRIRTKVTQELEVQSPPSRTTSPSSPRSLLSDFTGFV
The following text describes a protein:
Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Domain:
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
Sequence:
MAAPSPIPAGISKEQAFSMAQTEMEYRVELFNKLLRCTMYNFDISFDRSLLNAVDVLAQTCFVKCVDKRYKEAELNMGENSCIDRCVSKYWQVNGMVGQLLSAGKPPQ
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Sequence:
MENPHEKVQVGILARIVGNVERLNQSVATLNQELERINTRNRNLELMGQMCEHYGRATAFNLKTTGNRQGPV
The following text describes a protein:
Function:
Mediates inactivation of the TORC1 complex in response to amino acid starvation. Post-transcriptional regulator of nitrogen permeases (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEYSEEGWMDQADSFPPRLLAIFFALFDPLQGPIVACEAPAGSVTNVDGGKNCLLPFETISDYVIPKRELCNKTITVCTNHYQVIGHPISIIGSNYERNALIFNMCMIFHEEEDSACYIPLVKRLARNLEVLEKQIHYISDLNKRPVIFSVIEQILEDMNNFCECMIQLDDQNSINIKLFPVFPSPPTVKSFHVPILTAQLDLLMDKNWDMTVQKVYPFINGINSVQRIAELANVSYRSCQKCMEHFLYYGCLIIADIFQFHNIYAMTTNAPNLLQDPDFQRECTAYVSTNSSNAKNVTFATIFKLYCSLRQGLRVKDWMNENKEIFKGLDVRRLISFGTIKGLIYRVHKYPYLERRTMRNNLTEEEKKLLGLLDGKHHFDELCVTLKKSPKVVNEMIAGLGDACFIYV
The following text describes a protein:
Function:
May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
Sequence:
MSFSPLIRQLIESLRILPGVGQKSAQRMALMLLERDRSGGLKLAQALTAAMEGVGHCRQCRTLSEEELCPQCADPRRDDSLLCVVEGPLDVFAVEQTGYRGRYFVLKGHLSPLDGLGPEAIGIPELEARIRDGAFSEVILATNPTVEGEATAHYIAQLLAGRGLTLSRIAHGVPLGGELELVDGGTLAHALAGRRPIS
The following text describes a protein:
Function:
Involved in the digestion of the blood meal.
Subcellular Localization:
Secreted.
Sequence:
MGNKIINMPAARIGTQWLVILCVAMAASGTNLDSGICPVAGDSGCRGNPPDQARYDNYRIYNVEFENQEQIELFQKLEEQSDSLTFIGHAREVGQKLSILVAAHRVADIADLLKTYKVKHRVLTYNFQEKIDRNLAEVQPESIDASQLDWQHFFHLKTIYEWLDKMVEKYPNRVTVLDMGSSTQGNAIKGVKLTSNANNKAIFIESGIHAREWISPAAATYIINQLLTSQDPKVQQLAQDYNWIIFPCVNPDGYKYTFEHDRMWRKNRQLFGTCRGVDLNRNYPDHWNSTGSSSDPTRYDFAGPSAGSELETKRLIDFIRANAGKEQIKTYIALHSYSQMLMFPYGYTKERVSNYDDLQEFGKKASAAIKAESGRDYVSGSLFETIYPSSGGSMDWAHSEAGIPIAYTFELRGPPDSQDLFILPAVEIQPTASEAFTAIRAIVEAAAEKGYYK
The following text describes a protein:
Function:
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex, causes transcriptional pausing.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MVYLHFPSNLTEEELMLQTKYQKLKKKKKALQALKAPKPEPEKTPALKRPAEARDAREVAKKLLKSGAISAIPKPSEKTETTGFKRSRGLERKLSSSDRAPSGFQPFSSSQGSMVSNEEHVTHEARTKSKVPNLYENFISSRESDAEPASISPTNPKETPTSPAISPVFGYSITEEILKKAFQSFGNVVNISMEIEKNCGFVTFDKTTSADRAISEMNGSMVSGIQLKVSLARRQPVIEPINDASSSATWSTIAARNSQKGSYKDKRDLVTYEEELF
The following text describes a protein:
Function:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKSGGKGKFYDDDYDDGYDDAYADEEYEEEDWSAYGAPGEHAGASSTPAPPAGASHANLPPPSAGQWRCPLCTYDNLEQHLACDMCGTPRPAAESAQEGASSASKAPPLDPAPFAFDSPSPDDQVLAARRRGTGTAKKPPASLNGKPPPLQAVETKPTPKPYDPIRNRRQSAPAVELQESAAEGKKEKRGAEQGVRRLSLDDQVSDRGQGEPSSSGRGETSGATLPPGKRKWQSLPLSAYRPDEELLAEIRSRGGEKDVLNLIIVGHVDAGKSTLMGRVLHALGQVSQKEMHKNEKQSKEQGKGSFAYAWVLDEGAEERARGVTMTVAVAHFETPQKRIILLDAPGHKDFVPNMISGASQADATILVVDATPGGFEAGMEGQGGQGGQTKEHAQLARSLGVEQLIVAVNKMDAIEYDQERFTEIQAGLVPFLRQCGFKDSAVRWLPVSGLAGENLTEPPEAKELAAWYRGPHLLAAVDSFQAPVRLVAKPLRLVVAEVFKTRTLGSAAIGGKLEGGVLKQGSKVLVMPAGEVATVKGVERNGEAVTGAAAGDSVDVGLSGIEPNVLFAGSVLCHPDYPVPTATKVEVRLLTLNIVMPLLRGASLVLHAHSAKQPVRISELVSLLDPKSGQVAKAKPRVVTKNQSAVVELVAERSICLEAYTDYRALGRIALRDSGKTVAVGIVTKILET
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MPPSKKYPNAEWAGWIQEVANQATENNAKVSQTYCKAAKAIKNHPIKLNHPRDALSLPGVGPKVVKIITDRLEIWCQENQVSFPSQVPLNKDGSDSGLSSDDATRPRPRPAELVDEEDHNPKPRSASNCQKSSAHKAHPTAPSKPRAKKPYQPKPRDPAWGILAAMYTICEPTDLKKFSSREIIAERAARYSDCTYVDLREDTSNRYGSHWQSGIKALIKYEFVITHATLRPAKYALTRTGYEFATVIAAQEDIPLLDVNMGPNTLCFEKSASSSVSRDPIPRETAKPSGNAHSEVSREVNFNEKSLPGNLGSETGNSLDAVTGAPSAFRFSYLNNANQRVLQLGEAATRLNSKTKQSFYKIEYPCAQQLHQFRRNHVLVDEKESCITLPRQETMIGWLKSEKSIPTCPGLCPTRAPRKPDLAKTDRASTVNFLLMSEKNSSKPASNIYKPPEILQAASEFAVAADAHPEPRLAKCPSQVPAPMITSVTSEHAQPQSSMVQPKQAQPKSNTNSSGSRPRASFATADHVPGGVPVVQPKQALPKPNVNSSGSRPRASFATADHVPRGVPKPRASIGTIGSIANQVRAEVWKARTYSVMLVIDNREVQSQNNRDGIFHACLSRARQTMGDQVKVQQRPLAVGDAIWIAVHNETGNEVVLDSVVERKRLDDLCKSIVDARFHEQKARLKNSGLKDRIYLVESYYSHNNRDLYEQQIQTSQVEIMLLDDCHLQSTADWKESVEYLVMRTNVLNQLHQTIDLSVIPDKHIDRNSYLSFINELRRIRPDDYWVTSYNVYESLNGKSGNLTVQELWGRMIHQISGMSVEKVGEFVTRWPTPRSFTDEFFHQYYRSEGAASSAHGAPKDCLSKWIEDQFCSGAAHSRKKLGPALSKKIAELFSLSSY
The following text describes a protein:
Function:
Slow, weak voltage-dependent S-type anion efflux channel involved in maintenance of anion homeostasis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEIPRQEIHIEIDNSIPSSKEFKTGLADAKPVVLMSALRSLHAGYFRISLSLCSQALLWKIMIAPESPSMSHMHSKLPSMAFHLLWYLALVTQVSLCFLYALKCIFFFDKVKEEFLHYIGVNYLYAPSISWLLMLQSAPMMEPNSVLYQTLFWIFAVPVLTLDIKLYGQWFTTEKRFLSMLANPASQVSVIANLVAARGAAEMGWNECALCMFSLGMVHYLVIFVTLYQRLPGGNNFPAKLRPIFFLFVAAPAMASLAWNSICGTFDAVAKMLFFLSLFIFMSLVCRPNLFKKSMKRFNVAWWAYSFPLTFLALDSVQYAQEVKDPVGSGLMLIFSSISVLIFLGMMVLTAANSNRLLRHDPVLGSATDPKDKQKTLSLNATNQN
The following text describes a protein:
Function:
A type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to an intron retention.
Subcellular Localization:
Mitochondrion.
Sequence:
MALLQRASYLRLYYLRLMGSRPRLFSSSLSPALHRHSSTLSSPPFSSPSPSFRLKFQLTSVLSQRLIQRNAISSRFLSTEASQETTTSKGYSSEQIQVLEGLDPVRKRPGMYIGSTGSRGLHHLVYEILDNAIDEAQAGYASKVDVVLHADGSVSVVDNGRGIPTDLHPATKKSSLETVLTVLHAGGKFGGTSSGYSVSGGLHGVGLSVVNALSEALEVSVWRDGMEHKQNYSRGKPITTLTCRVLPLESKGTKGTSIRFWPDKEVFTTAIEFDHNTIAGRIRELAFLNPKVTISLKKEDDDPEKTQYSEYSFAGGLTEYVSWLNTDKNPIHDVLGFRREINGATVDVALQWCSDAYSDTMLGYANSIRTIDGGTHIEGVKASLTRTLNTLAKKSKTVKEKDISLSGEHVREGLTCIVSVKVPNPEFEGQTKTRLGNPEVRKIVDQSVQEYLTEFLELHPDILESIISKSLNAYKAALAAKRARELVRSKSVLKSSSLPGKLADCSSTDPEVSEIFIVEGDSAGGSAKQGRDRRFQAILPLRGKILNIERKDEAAMYKNEEIQNLILGLGLGVKGEDFKKENLRYHKIIILTDADVDGAHIRTLLLTFFFRYQRALFDAGCIYVGVPPLFKVERGKNAQYCYDDADLKKITSNFPANASYNIQRFKGLGEMMPEQLWETTMNPETRILKQLVVDDIAEANMTFSSLMGARVDVRKELIKNAATRINLQRLDI
The following text describes a protein:
Function:
Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNTTKRILAIQSSVCHGYVGNRAATFPLQLLGWDVDAIPTVELSNHAGYPIVKGRTLSAEQILDLYKGVSAANPSGYECLLTGYARGIGSVKAIMEIVRSVKSKNKKAFWVFDPVLGDNGRLYVEESIIPLYREMLPFADLITPNGFEAEILSGMRINSIDTAFKCVECLQQKYKVPRVVISSFVVEENGVEKLYCIGSSIYSKSFFVLIPVIPGIFRGTGDLFTALMAAHIAESPDCTESLASIKEDKLKKSVEMALSSVHEVIQKTADRISALGVEEYHPAYAELCIVNSQNSIIAPSKLFEAVYYY
The following text describes a protein:
Function:
Acts as an inhibitor of protein phosphatase PP2A (By similarity). Together with TOPBP1, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (By similarity). The CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (By similarity).
Subcellular Localization:
Cytoplasm. Chromosome. Note=Predominantly localizes within the cytoplasm (By similarity). Localizes to broken chromosomes within micronuclei during interphase and following chromothripsis (By similarity).
Sequence:
MDASGCMKSLLLAATQYRAAKTPSNAALVQRSLEVISGLKLTRLFASNQILPSECLNCLVELLEDANIDPPLTLSLVTLLSQLASDSETREALRDTYSLTNVLAGVVHRSSTNLSDPVLLQSIQLLQRLTYNVPVFCAGANIDELISFLMHHVQSTEDELTIPCLGLLANLCRHNLPIQTQIKSLNNVKSFYRTLISFLAHSSLTMVVFALSVLSSLTLNEEVGEKLFHARNIHQTFQLIFNIVVNGDGTLTRKYSVDLLMDLLKNPKVADYLTRYEHFTSCLGQVLDLLHGKDPDSSSKILELLLAFCSVVELRHTLRQAILEPSGLPVSGNTRFVTRSKTFEPSVALVHLSNQPLEGSEDCSVLALQLFKEVFEDVISSGNSASAEHFVDLLLPVLLDHLQTPEQIVDELLVKKKCERMVKTINVLTVLCRDDILKTHASKLLTASQCVSLIEHQFSYSGIDAGFGTKVVDSKMCKLAADIILKTLDLMSRLKQDVPGMEVSFYKILQDQRLITPLTFALTSDYREQVQVGLRILFEAAPLPDFPAILLGESIAANNAYRQQEKEHASKRIQLQSPLISNVTVSSSSCANGDESTASNVQELIQKLHSGLEVKEPITDMRISDIMDIYEQKLSSLASKETRLQDLLEAKALALAQADRLMAQYRCQRAQAESEARTLAAMLKDAERKNEELNVLLKAQQVESERAQTDIEQLFQHNRKLQTVAEEHEMLKKSSVDLLQRYETTERQHKDLRITCNSLNKEIEAMKKLNESLKQQNDRTAAQLVESEEHRKELQQQLHDRESKIASLQQKIKGLEEKLKAQQKEKNSMEETVDVLRKELSKTEQARKELSIKASSLEVQKSQLEVRLEEKEALVKLQKEELNKHSTMIAMIHSLSGGKLSAEAVNLSL
The following text describes a protein:
Function:
Required for apical extracellular matrix organization and epithelial junction maintenance.
Subcellular Localization:
Apical cell membrane; Single-pass type I membrane protein. Note=In the excretory canal cell at the 1.5-fold embryonic stage, localized uniformly at the cell membrane.
Sequence:
MRLLLCLLLFSTLLINSTNACPGVITQACFCSEVHSGIVLDCSNSSASGILQIIRTNQAQVGLIQSLTMNQAELVELPPNFFSGLFIRRLDLSQNKIKKIDDAAFAGINPVLEEVVLNHNLIEKVPAAALAGLPNLLRLDLSNNSIVEIQEQEIFPNLNKLYDINLGSNKIFSIHTSTFQNVKNSIQTINLGHNNMTAVPSSAIRGLKQLQSLHLHKNRIEQLDALNFLNLPVLNLLNLAGNQIHELNRQAFLNVPSLRYLYLSGNKITKLTAYQFQTFEQLEMLDLTNNEIGAIPANSLSGLKQLRQLYLAHNKISNISSNAFTNSSIVVLVLSSNELKTLTAGIISGLPNLQQVSFRDNQIKTINRNAFYDAASLVMLDLAKNQLTEIAPTTFLAQLNLLLVDLSENKLPKTPYSAFNSRVGTVLLKENPLVCTENLHMLQQGTGVYVRDSPDIICGRKPTPKPEPVLVPIVTDSLISTQRPALVQIPKMQIHRNVHTTTGDQAPQIPSGAFQQIDLGKSRSLPRGHSRFILDKPSTREQSVEPTEELTPIQPIILPSREDEIRQSSMEAGTSQESVEATSQKIPSTTDIIDRPNVVLPFPVPFLKRGPNLSESKKVESTDMPSTSQVFHTLPPSILIEPGSTPKVAQPSTEANIKSEHIDEFALASSNSNEPTLQPRLEKSFFTTTIIFICVGTAVIVLVVVIAGLCISKHRQLQFENTYSDSSAARTSEYISTQYRQNSLRGTGGRVGRFEESPAWIYNPGSSYCNYYK
The following text describes a protein:
Function:
Probable transcription factor acting as a positive regulator in the ethylene response pathway. Could bind the primary ethylene response element present in the ETHYLENE-RESPONSE-FACTOR1 promoter.
Subcellular Localization:
Nucleus.
Sequence:
MDMYNNNIGMFRSLVCSSAPPFTEGHMCSDSHTALCDDLSSDEEMEIEELEKKIWRDKQRLKRLKEMAKNGLGTRLLLKQQHDDFPEHSSKRTMYKAQDGILKYMSKTMERYKAQGFVYGIVLENGKTVAGSSDNLREWWKDKVRFDRNGPAAIIKHQRDINLSDGSDSGSEVGDSTAQKLLELQDTTLGALLSALFPHCNPPQRRFPLEKGVTPPWWPTGKEDWWDQLSLPVDFRGVPPPYKKPHDLKKLWKIGVLIGVIRHMASDISNIPNLVRRSRSLQEKMTSREGALWLAALYREKAIVDQIAMSRENNNTSNFLVPATGGDPDVLFPESTDYDVELIGGTHRTNQQYPEFENNYNCVYKRKFEEDFGMPMHPTLLTCENSLCPYSQPHMGFLDRNLRENHQMTCPYKVTSFYQPTKPYGMTGLMVPCPDYNGMQQQVQSFQDQFNHPNDLYRPKAPQRGNDDLVEDLNPSPSTLNQNLGLVLPTDFNGGEETVGTENNLHNQGQELPTSWIQ
The following text describes a protein:
Function:
Member of the two-component regulatory system SrrA/SrrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels as well as biofilm formation. Also plays an essential role in host-derived nitric oxide resistance by regulating hmp/flavohemoglobin, an enzyme that detoxifies nitric oxide by converting it to nitrate. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to SrrA. In turn, SrrA binds to the upstream promoter regions of the target genes to positively and negatively regulate their expression.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMSRLNSVVIKLWLTIILIVTTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQSHNKEEAIKYSQTLIENPGGLMIINNKHRQSTASLSNIKKQMLNEVVNNDHFDDVFDKGKSVTRNVTIKEKGSSQTYILLGYPTKAQKNSHSKYSGVFIYKDLKSIEDTNNAITIITIITAVIFLTITTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQMSTEIEEHVDALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKAFLLRQIEDTFKSKQTEMRDLEMNARFFVVTTSYIDKIEQGGKSGVVVTVRDMTNEHNLDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESLAIVLDESKRLNRLVNELLNVARMDAEGLSVNKEVQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWSYDMDRMDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLPKPE
The following text describes a protein:
Function:
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Subcellular Localization:
Secreted.
Sequence:
MKAVVLTLAVLFLTGSQARHFWQQDDPQSPWDRVKDFATVYVDAIKDSGRDYVAQFEASALGKHLNLKLLDNWDSLGSTFTKVREQLGPVTQEFWDNLEKETEALRQEMSKDLEEVKKKVQPYLDDFQNKWQEEMETYRQKMAPLGAEFREGARQKVQELQEKLSPLAEELRDRLRAHRRPAPAHGRPLRGAQGGRRQPGRVPGQGPGAAESAGREGQAGAGGPPPGPAARAGEPQGQHPGRHRRGLQEAERPVRRPPPALPSPSVRLLGISSSGAGRL
The following text describes a protein:
Function:
Degradation of glucosinolates (glucose residue linked by a thioglucoside bound to an amino acid derivative) to glucose, sulfate and any of the products: thiocyanates, isothiocyanates, nitriles, epithionitriles or oxazolidine-2-thiones.
Subcellular Localization:
Vacuole.
Sequence:
MTQGKRSFDKKKSFGRADFPQGFLFGTASSAYQYEGAVKEGSRGESIWDTFARKYPERNCHSNADETIDFYHRYKEDIQRMKDINMDSFRFSISWVRILPRITPLATLFHWDTPQALEEEYGGFLSENITMDFRDFANICFEEFGDRVKLWLTINEPWVYSVGGYDAGRKAPGRASKYMNDAATAGKSGHEAYIVSHNLLLSHAEAVEAFRNCHNCKDGKIGMAHCPLWYEPYDVTCDEDVEAAERAMEFMFGWHMNPTVHGDYPEVMKKIVGKRLPSFTESQSRKLKGSFDFIGINYYSSVYAKNVDEVDPDKPFWRSDQHVEWKKQNKAGKAIGAQGGVEWNLMYPQGLRKVLNYAKNKYGNPKFIITENGHCDAYEEKKPKLYELMDMKRTDYHKKHISNVHQAIYEDGVQVDGYFAWSLLDNCEWNCGYEIRYGLFYVDYENGLKRYPKMSAMWFKEFLKEKDDDKIKKPQVKRMPRRPSGGRRFIKHQPLAFSPFMRSLALASRRKLHRHQQEDDSPRSEELMSFDQKLPTLSKKEQKEQLSDSSDEEDSQGDVQADFEFFDPKPTDFNGVKILLKNYLDDKEWDLSSFVDLVLEQTTVGTVVKVADDEDESVFAVVSALNLARYKEHKCFRELKEFLLQVCSEKSVAKDLGVMLEKKAHDVGILVSQRVMNLPPQLLPPLYDGLFDEVSWATEDEPTEELRGSFRFKWYLLVTKIYKLKNPKQRKPRRGEEEEEETVFLKPEDELFLQLSSWSFTYPMRSQLVTSHEMKNYQLMGLVMAVEAKRIPEFRQMLNSLID
The following text describes a protein:
Function:
Vital for larval development. Plays a role in tumor formation. A crucial component for the physical link between integrins and the cytoskeleton in the epidermal muscle attachment sites.
Miscellaneous:
MISCELLANEOUS: 'Wech' means 'detached' or 'gone' in German.
Sequence:
MMELLSNNSVPQQMASSNAPSANNVAHSSTANGSGGGSVSSNASNSSERLLAGILESFPAWDLNVGLLPNVGQSSPPRADFFINNFLGGLDTHGDFSIGPIGSGARSNPKMSPESSNNSSISCGWCEVSASIRCLECNEFMCNDCLREHRNSPLSSNHSIVSLPTPIGASPTGGSSVNAQTPPSGNFICDIHNEMLRYVCDYCRKLVCQCCTLHEHKEHSYASIQSFMVGSKEKLEGAIESSQVGTRCIKSSIDKALAFIRLIERNCSELSDNIRKAFRQFIIAIEDRERFLLDFVEKLRQRRLAILHDQMAGLKSALAGLSETSDMLSKVADNACNMDQIEIAMKLTNGQRQMEQFAGIYKDLQPKQEVFAFAPPDYSLLQDIRNQGGVILVDDKNLPIVSSSNGIVPSVSSVNAVAAASVGVVGGVAGVVGGVGVSNGLDLAFGMNMPNNPLSVASSSVRRPLLRDNSFRIPSPIMQPRGGSACGMSSGMSSAALDWELNGLRSSPGLHFSAPRTTQAIPGCMDLVKVRNSNALSLSFATEGHEDGQVSRPWGLCVDKMGHVLVSDRRNNRVQVFNPDGSLKFKFGRKGVGNGEFDLPAGICVDVDNRIIVVDKDNHRVQIFTASGVFLLKFGSYGKEYGQFQYPWDVAVNSRRQIVVTDSRNHRIQQFDSEGRFIRQIVFDNHGQTKGIASPRGVCYTPTGNIIVSDFDNHCLYLIDPDINDILSVKGHEGSGFHEFNRPSGLCCDDEGRIIVADSKNQRILVFNQNLDFMWDIEVRPSINPLMPPTLDEKDRTCDVAIMPDGRIVFLIELSPDSKEGSNPYKRFVHVF
The following text describes a protein:
Function:
Serine protease inhibitor that inhibits trypsin at a molar ratio of 1:1 (Ki=160 nM). Is thermostable.
Miscellaneous:
MISCELLANEOUS: Negative results: has no effect on chymotrypsin and elastase. Shows weak inhibitory activity on mKv1.3/KCNA3 potassium channel currents (1 uM inhibits 50% of currents).
Subcellular Localization:
Secreted.
Sequence:
MKSFLLIALVLFFLFVSYASAKNKCQLPSDVGKGKASFTRYYYNEEGGKCETFIYGGVGGNSNNFLTKEDCCRECAQGSC
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MASALVTKYLTLYNSISTFLWFAVLARLLILLPLVGYDYVSGGLRDFLIGVQTLAGLEIFHSLFGLVRSPLQTTVMQIFSRFALVWGVLYQYPQTGTDIFFTFMVIAWSVTEVIRYSFYALNLAGWGVPDWHQWIRYNFFLVLYPLGVSGEMKLMWNAIAYARTEQPYFALFLKAAMVIWPIGLYILYSHMLKQRSKHYRQVIKKDR
The following text describes a protein:
Function:
Involved in sporulation.
Subcellular Localization:
Forespore outer membrane; Peripheral membrane protein. Spore coat. Note=Forms two rings around the forespore that are offset from its midpoint, before it eventually redistributes to form a shell around the developing spore.
Sequence:
MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVAYRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFKDRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYDRLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSELTPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSDAASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISGKNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGFDFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEALWPS
The following text describes a protein:
Function:
Toxic component of a type II type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB6 (By similarity).
Sequence:
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVGALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD
The following text describes a protein:
Function:
Stimulates the secretion of gonadotropins.
Subcellular Localization:
Secreted.
Sequence:
MVHICRLFVVMGMLMFLSVQFASSQHWSHGWYPGGKREIDVYDPSEVSEEIKLCNAGKCSFLIPQGRNILKTILLDALTRDFQKRK
The following text describes a protein:
Function:
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MKRTIQETPGPSSTTVPPPKKLNSQRNGSNLEPGSIYFTPIGGISVPRQESESSRSLDEILADIRPINSLHFSFMLDFEFLIGSYPPSLREYPITLVVGAPDAPDLLKCTKNQKLVTVVGASLPIPFGTHHTKMSILEDEDGRFHVIVSTANLVPDDWEFKTQQFYYNFGVKIASGTVPRSDFQDDLLEYLSMYRNQLDTWKQLLQKVDFSQISDRLIFSTPGYHTDPPTQRPGHPRLFRILSEKFPFDASYEHTERCTFVAQCSSIGSLGSAPINWFRGQFLQSLEGANPSPKQKPAKMYLVFPSVEDVRTSCQGYAGGCSVPYRNSVHARQKWLQGNMCKWRSNAKRRTNAVPHCKTYVKYDKKVAIWQLLTSANLSKAAWGEVSFNKSKNVEQLMIRSWEMGVLITDPSRFNIPFDYPLVPYSATDEPFVTDKKHEKPDILGCIWTPP
The following text describes a protein:
Function:
Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes. Implicated as an osmoregulatory substance important for seawater adaptation.
Subcellular Localization:
Secreted.
Sequence:
MARVLVVLSVVVASLFFSQGATFENQRLFNNAVIRVQHLHQLAAKMMDDFEEALLPEERKQLSKIFPLSFCNSDSIEAPAGKDETQKSSVLKLLHTSYRLIESWEFPSKNLGNPNHISEKLADLKMGIGVLIEGCVDGQTSLDENDAFAPPFEDFYQTLSEGNLKKSFRLLSCFKKDMHKVETYLSVAKCRRSLDSNCTL