lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MVNKVTRKKHYRPPGQKKEGNAARYVTRSQAVKQLQIGLPLFRKLCIYKGVFPREPKKKVKGNHHTYYHLKDISFLHHEPLLEKCREIRAYEKKIKKADAKKNKERANFLIERRPTYLSGLLRIIKERYPKFIDALRDLDDCLSLVHLFAALPAQERLKVEAKRIHECRRLSHEWQAFISRTHKLRKVFISVKGIYYQAEVEGQKITWLAPHALHQILTDDVDLTVILNFMDFYEKLLAHVNKHLFNSINLEYPPILDPRLEALAADFYALLRFFDANTRTSLLNPQTSSSSQFGQVDAEDSELRLAQLQHQLPLNEPTALMHLVEDASGMDEDEDEDTRECKKLFKNMKFFLSREVHRESLLFIIPAFGGMVSWEGDGAPFKESEKTITHQIVDRSTQTHKFLSRDYVQPQWVFDCVNNRIILPTEDYLVGRDPPPHLSPFVDNDAEGYVPDYAVTLNKLKADAKNEILPLPGVGKEDLDDPQKLLDAGVIDRAKAIEAAEMKQKMMALEKEYHDELKLELQGGKYSSAISNVDKQLPDQEKEGGEDTNLPDYQQMAEDTDKLSKVMMSRKKKSLYEAMQIGKRTKKGKIDLLHERKKKHKESHKSQ
The following text describes a protein:
Function:
Involved in the inactivation of ecdysteroid molting hormones by converting ecdysteroids into 3-dehydroecdysteroids.
Sequence:
MGDQRVHKPRTAKTRTLRVNRILLPMLLLFSGETTSVVTQLFSVDSSGLGISLMQSVAIALNASSLALANNTAWPLQHEPPEDRLEIESYDYIVVGAGSAGSIVASRLSELCQVKVLLLEEGQLPPLESEIFGLTGALHHDERYMFLEEAVPNPKCCQAMASMHGCVWWHGRMMGGGGAINGNIFIPGSRENFRRWNSTGWDWTQVHKTYSRLQQRLNPSYLQPNKLNLKLANLIYSGSAELGVPRMKQPLIAGATFGYTHHVPVTVNQRRRASSARLYLANDQVNRRGNLKVIRGAQVQRVLLNAAGSRATGVIYTLNGVEHTAKTLGEVILSAGTLNSAKLLLLSGIGPREELQRWNITTHQDLPVGRNLQDHGMMPLFLLFGSNCAVNSTRDPTENPYAPVSITQYLLDNQKGPLASGFYMMGYINSSSPSSSRGEPDLHVVAHTLLPKGSTGSFGYLGFRPELIQAQQDILQKGDLLQIMGSLLRPLSHGKVSLSSKNSADQAKIENHYGEAVEDQQTLLRYVRYIQKLSKTRPFRRCGLRLWKPPLHECDTLAADSDDYWLCYIRYFYVGAWHSVGTCRMAPRKGVDSQENGGVVDERLRVHGVKGLRVVDASIMPELPAGNTNGPAMMIGEKGAQMILDDREANNEVIQEC
The following text describes a protein:
Function:
Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A).
Sequence:
MEAGQQWPGKTDFYLQLPKVELHAHLNGSISSSTMKKLIAKKPHLNVHGHMTMIDKGKKRTLQECFQMFQVIHQLTTSAEDILMVTKDVIKEFADDGVKYLELRSTPREENATGMTRKTYVESVLEGIKQCKQENLDIDVRYLMAIDRRGGPTIARETVELAKEFFLSTENTVLGLDLSGDPTIGQANDFLEPLLEAKKAGLKLALHLAEIPNREKENQMLLSLLPDRIGHGTFLSASEAGALDQVDFVRQHQIPLELCLTSNIKSQTVPSYDQHHFGFWYSIAHPSVICTDDKGVFATYLSQEYQLAAETFNLTPFQVWDLSYESINYIFACDNTRSELRKRWTHLKQKVLNCNEVNYF
The following text describes a protein:
Function:
Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (By similarity). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts. Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs. Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (By similarity). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity).
Subcellular Localization:
Nucleus, nucleoplasm. Cytoplasmic granule. Secreted, extracellular exosome. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Not found in the nucleolus. Found in exosomes follwong sumoylation.
Domain:
The disordered region, when incubated at high concentration, is able to polymerize into labile, amyloid-like fibers and form cross-beta polymerization structures, probably driving the formation of hydrogels. In contrast to irreversible, pathogenic amyloids, the fibers polymerized from LC regions disassemble upon dilution. A number of evidence suggests that formation of cross-beta structures by LC regions mediate the formation of RNA granules, liquid-like droplets, and hydrogels.
Sequence:
MEKTLETVPLERKKREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKHHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGGGNFGGSPGYGGGRGGYGGGGPGYGNQGGGYGGGYDNYGGGNYGSGNYNDFGNYNQQPSNYGPMKSGNFGGSRNMGGPYGGGNYGPGGSGGSGGYGGRSRY
The following text describes a protein:
Function:
Protein involved in mitophagy. Accumulates on the mitochondria surface in response to mitochondrial depolarization and acts as a 'eat me' signal by recruiting proteins involved in selective autophagy.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MVKAGSSLQTTGRALLTAAARRFSESSDKGWLRSLFVQKVDARKDAHSNLLSKKETSSLYKIQFHDVKPECLDAYNSLEAEVQKKLHQDQDFPCEVVGSWNTWYGEQDQAVHLWRYRGGYPALTECLQKLRANKEYLEFRRERSKMLISRRNQLLLEFSFWNEPLPRRGPNIYELRTYKLKPGTMIEWGNRWARAIKYRQSNNEAVGGFFSQIGDLYVVHHLWAYESLQSREETRNSAWRKEGWDVNVYYTVPLIRSMESRIMIPTESSPLQ
The following text describes a protein:
Function:
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
Sequence:
MIQIFFLGTGAGSPSKKRKLPAFLVRREGVNILLDCGEGTQYTLMNYKLGINSIKIIGISHMHGDHVFGLLGVIASMGLLDRKETLYILGPRKLKDFLYTSFEYSKFNPSFKIEFIDNYNDENITISTFKTCHTIESQGYLIMEKDRVKIDEEKLEKEKIRDWRVIRKLKEGKTVEYNGKLLKPEDYLVIKRGSKVAYTGDTMPCQSVVDSVKGVDILIHDSTFLDEPSAYTYGHSNVTDAAKIALEASVKLLALTHISPRYEDVSEHLKMARRIFPKSILPDDLSYITIK
The following text describes a protein:
Function:
Endosomal E3 ubiquitin-protein ligase that regulates the recycling endosome pathway. May play an indirect role in regulation of gene expression during embryonic mesoderm formation.
Subcellular Localization:
Endosome membrane; Single-pass type I membrane protein.
Sequence:
MYIRKTLLLACLVLLFGGLPPLTFPATTTTLVAAMSIANQDLERYFRPGNGTHSFSGMEDRIAVDVYNYAFLNWSYVEHGNMLCNMEFAQEQARYGEGKVLNVTGRLIHITATDNFSDDYACTPYIRGTLGAPIPDKGETWIALVRRGRCTFEEKVKHVYQQNAAGVIIYNDKQVMQLEKMQIKGKTRNIAAVITYQNIGQDLSLTLDKGYNVTISIIEGRRGVRTISSLNRTSVLFVSISFIVLMIISLVWLIFYYIQRFRYMQAKDQQSRNLCSVTKKAIMKIPTKTGKFSDEKDLDSDCCAICIEAYKPTDTIRILPCKHEFHKNCIDPWLIEHRTCPMCKLDVLKFYGYVFLGSEESILEYQPDPPQGLALVEARDESADLNRSRDFVVDFPRVFVLDSGCVVGAREMLFPCRIPERSQSSLSLRQARDWVSLMSNKLEEQQGLRSMRNDEMQQVIK
The following text describes a protein:
Function:
Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum. Golgi apparatus, Golgi stack. Nucleus.
Sequence:
MLSNPQAFRVFTGFCPDPECRTKLYFPSYAGSNIECTRCGQHHLKSSLLNVELVTDPEVALRSLLRSSLLSRSSFKKEAELVKVKGYSNYHCKLLAPLMTRYGMERTSGKARLLKDMNQGDSFDCSHIGDRAFVIEPEFLETIGYGKDKTGAVTYLADTLTAIKSVNNMEERLVPIHVDGDGHCLVHAVSRALIGREIFWHALRTNLSSNFQQNLAKYRALFKDFIDEAEWRDIIKEASPNFVAPEGQSLGMRNIHVFGLANVLHRPIVLLDKLSGMQSIGDYSATFLPALIPVHECKSKNGQLYPPLVIAWSSAGHNHYIPLVGVSGRPIPKCPRWLVPKAWGLPNELIDAYIKFDENDCCNIGGEHCLPEKYIQRLMRAMDEQFLEIHSVTASLITDVHQFLYKSSGLVGISPQMVIESTQQSIKDGHLKRCLSCHAVLEQKPPVNEEWLRPGGDMYTAASQTPGGLIDAQMYTFPQQELVCSYDQQSDVLHPGLLLSACTLCKGPLRTVKGDGSPVYINGDRTSTPVQGASTCKCGFKHFWDGKEYDNLPEVIPVTLEWGGKAVKETVHWFQNERDVSMNSNVYAVASKLVQKYFPGEFGSERLVQKVVDTILRQTAKKEGENKGLFDKKLNLNHCLLCQVQLLFVPSKIILTGEKKKTFHKEELTMSEAEKLIRTRTEHHAAVMQKRQSGSTTVKKTPEKGSPPPKQVASPVPEKKLSTPPLSPRTEKKIRLSSSKGGQATLSLPLDATYRQLQDAIHKELGVQPEHQKIRYGFPPRTLSPPEEGNEGEAVPIQHGDRVMVEVIIPP
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MSFPNSSPAANTFLVDSLISACRSDSFYSNSASMYMPPSTDIGTYGMQTCGLLPSLAKREVNHQNMGMNVHPYIPQVDNWTDPSRSCRIEQPVTQQVPTCSFTANIKEETNCCMYSDKRSKLVSSASEVPSYQRLVSDSCPIENPEVPVPGYFRLSQTYATAGKAQEYNNGPEASSSTVMLQLNPRGASKPQLASQVPMEKKMNENPSNSGSNANSSSSNASSTTTSNHHQHHHHHHHPDNNSAKVAQVESPEPKSVSLQEDRGCLPEAPVSSPEAQEKDSKEEIKSDTPTSNWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISKSVNLTDRQVKIWFQNRRMKLKKMSRENRIRELTANLTFS
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
Subcellular Localization:
Plastid, apicoplast.
Sequence:
MKKYIYIYFFFITITINDLVINNTSKCVSIERRKNNAYINYGIGYNGPDNKITKSRRCKRIKLCKKDLIDIGAIKKPINVAIFGSTGSIGTNALNIIRECNKIENVFNVKALYVNKSVNELYEQAREFLPEYLCIHDKSVYEELKELVKNIKDYKPIILCGDEGMKEICSSNSIDKIVIGIDSFQGLYSTMYAIMNNKIVALANKESIVSAGFFLKKLLNIHKNAKIIPVDSEHSAIFQCLDNNKVLKTKCLQDNFSKINNINKIFLCSSGGPFQNLTMDELKNVTSENALKHPKWKMGKKITIDSATMMNKGLEVIETHFLFDVDYNDIEVIVHKECIIHSCVEFIDKSVISQMYYPDMQIPILYSLTWPDRIKTNLKPLDLAQVSTLTFHKPSLEHFPCIKLAYQAGIKGNFYPTVLNASNEIANNLFLNNKIKYFDISSIISQVLESFNSQKVSENSEDLMKQILQIHSWAKDKATDIYNKHNSS
The following text describes a protein:
Function:
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MNDGNHYRPAISPNPSADTQPSDWAYIAEGGAHIVFSYQGRSKTYATRALRVRKPSATTEPLAQAEENDLFGQWRRNILPKLLPRQLLTTSREVILEDRWYKELLAMVDVVRPDQRKSGIDFAAKGDRRGVLLEDLTSSEDDGAIAVAIEIKPKWGFLPCTEHLHPPESVSIKSHVSRFRLHQHFRGCSDDPPYDPLDLFSGDKMRMRTALDGLWTMWEISRGKVNNWKVFVGGKEISPDDLQNGLLPIGGDDFVTKITQLTLDTLQTSFALPLLKNLQQNLDPIDISSLAALFQAEYPNSPPFDPDLIPDVSAVELNGFVDIYISDPQAGQRMDSWSLRERIIAYALSAIFKDCSLFIRGFLKHAEDGVWRLVSGSDSVKVIDLDLKPIKNIQKWAETDEKVWKYWLETKGAR
The following text describes a protein:
Function:
Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MMKKKISAKKKNQQQQQLHQPTMSEVTEEERTRYEEEEDVRDSPSDSSEESEDDEEEIQKVREGFIVDDEEDEVQTKKRKSHKRKRDKERPHYDDALDDDDLELLLENSGLKRGSSSSGKFKRLKRKQIEDDEDEIESQDHQGEQQLRDIFSDDEEVEEEAAPRIMDEFDGFIEEDDFSDEDEQTRLERREQRKKKKQGPRIDTSNLSNVDRQSLSELFEVFGDGNEYDWALEAQELEDAGAIDKEEPASLDEVFEHSELKERMLTEEDNLIRIIDVPERYQMYRSALTYIDLDDEELELEKTWVANTLLKEKKAFLRDDWVEPFKQCVGQVVQFVSKENLEVPFIWNHRRDYLEYVDPDAPIPGSVRELMISEDDVWRIVKLDIEYHSLYEKRLNTEKIIDSLEIDDELVKDIKTLDSMVAIQDMHDYIQFTYSKEIRQREETQNRKHSKFALYERIRENVLYDAVKAYGITAKEFGENVQDQSSKGFEVPYRIHATDDPWESPDDMIERLIQDDEVIFRDEKTARDAVRRTFADEIFYNPKIRHEVRSTYKLYASISVAVTEKGRASIDAHSPFADIKYAINRSPADLIAKPDVLLRMLEAERLGLVVIKVETKDFANWFDCLFNCLKSDGFSDISEKWNQERQAVLRTAISRLCAVVALNTKEDLRRECERLIASKVRHGLLAKIEQAPFTPYGFDIGSKANVLALTFGKGDYDSAVVGVYIKHDGKVSRFFKSTENPSRNRETEDAFKGQLKQFFDEDETPDVVVVSGYNANTKRLHDVVYNFVSEYGISVKSEFDDGSSQLVKVIWGQDETARLYQNSERAKKEFPDKPTLVKYAISLGRYLQDPLLEYITLGDDILSLTFHEHQKLISNDLVKEVVESAFVDLVNAVGVDINESVRDSRLAQTLKYVGGLGPRKASGMLRNIAQKLGSVLTTRSQLIEYELTTRTIFINCSAALKISLNKSINVKDFEIEILDTTRIHPEDYQLAMKMAADALDMDEESELHEKGGVIKELLENDPSKLNLLNLNDFANQIYKLTHKLKFRSLQAIRLELIQGFAEIRSPFRILTNEDAFFILTGEKPQMLKNTVIPATITKVTKNHHDPYARIRGLKVVTPSLIQGTIDENAIPRDAEYVQGQVVQAVVLELYTDTFAAVLSLRREDISRAMKGGVVREYGKWDYKAEDEDIKREKAKENAKLAKTRNIQHPFYRNFNYKQAEEYLAPQNVGDYVIRPSSKGASYLTITWKVGNNLFQHLLVEERSRGRFKEYIVDGKTYEDLDQLAFQHIQVIAKNVTDMVRHPKFREGTLSVVHEWLESYTRANPKSSAYVFCYDHKSPGNFLLLFKVNVSAKVVTWHVKTEVGGYELRSSVYPNMLSLCNGFKQAVKMSSQQTKSYNTGYY
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTPHALISSDFHDVIKPLINLTKIFGFLPVCSSQKGQKTCLNLSINYCICGYIFSAILFSLSILGLTEDLNSAPIRMKNPIVKYIILIDLGEVAVTVLAGILTTPFKLPYFWKMLTGFGKIEQVLPPHHAPEEKKRSFWAVTIFLVLAASVIFFDVVVWGLSASDLGVFFKRFLPVYVSYLLIFVQQIPFCFFVRVIRLKIEDLNGAFRAGLERVQNGENQWISVMKVNKQPKVIQGKSALSYERLNEFMRLVEEIEDVIEAINGFYGVHTLLILFSCLLHLVVTPYYLLIEVCNAGYLPFILLQVAWIVLHLIRLMVIVETCQRCIDEYQVTTNLVLKLLTSPLLPDIKEQVEILAVQVSNKKIKFSSFGMLKISRSLLTSFGGALTTFLVILFQYGGIHGNVY
The following text describes a protein:
Function:
One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular Localization:
Cellular thylakoid membrane; Single-pass membrane protein. Membrane; Single-pass membrane protein.
Sequence:
MLNTFSLIGICLNSTLFSSSFFFGKLPEAYAFLNPIVDIMPVIPLFFFLLAFVWQAAVSFR
The following text describes a protein:
Function:
Probable RNA-binding protein that specifically binds to the fourth chromosome and may bind an RNA that spreads the fourth chromosome. May be a reminiscence of X chromosome dosage compensation of ancestral Drosophila species in which the X and the fourth chromosomes are one single chromosome.
Subcellular Localization:
Nucleus. Chromosome. Note=Specifically binds to the fourth chromosome.
Sequence:
MDSKRAALESGDGPDAKRLDTTDDQDKEASGGDGSQVMLAKHVAPYTGHGCTPPMESYLFEPTPAGSQLLPWKTSVDLDNDAELEKPTSDKKPDTAKLSRRELAKMRREHTLRALALERELTNKPGQTPASEVLLVRFPDPEITAPMLAGLSKDIRDVVLPISVAPRYCLVHLKAGADVEATICDINRVRFGTGHLRAELKPFSDEEQAEFIDPCSLYVGNIPFNMTTSAIKAYFANAMRVDIGVLKREKRARYAFVRYASPDQTMEAFKELVDSPLNSRTLTVRYRRLRKRAGMPMVQCATSFQALQSPNGDDDNTDCKVISPPPLESIIISDSDNCSDSSGNGKEDGKRKKKINEQEREIEKLKRQMAEYGAIIKSLQFRQNSLEDTFIPDLTPKVEPSVNPTGCLLGSNAVHLMRDIKKECDYLGIPDPVPATKPTTQAQDDSQKKAKRSCFGRLFTGPFRRGTSAMKTADEYEKDDRLEELYAQLERDPDP
The following text describes a protein:
Function:
Cinnamoyl-CoA reductase probably involved in the formation of phenolic compounds associated with the hypersensitive response. Seems not to be involved in lignin biosynthesis.
Sequence:
MLVDGKLVCVTGAGGYIASWIVKLLLERGYTVRGTVRNPTDPKNNHLRELQGAKERLTLHSADLLDYEALCATIDGCDGVFHTASPMTDDPETMLEPAVNGAKFVIDAAAKAKVKRVVFTSSIGAVYMNPNRDTQAIVDENCWSDLDFCKNTKNWYCYGKMLAEQSAWETAKAKGVDLVVLNPVLVLGPPLQSAINASLVHILKYLTGSAKTYANLTQVYVDVRDVALGHVLVYEAPSASGRYILAETALHRGEVVEILAKFFPEYPLPTKCSDEKNPRAKPYKFTTQKIKDLGLEFKPIKQSLYESVKSLQEKGHLPLPQDSNQNEVIIES
The following text describes a protein:
Function:
Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MFECDCRVNESRNTLHSVAAHIKKISRINTEDWDLHKIAVALKIICCPEENNAATQQWFSTQHLRKLKFDAPKYKMFLKEASLALYDEVHHHCDLRFKAGQELTRLIKLAKKVDVEQPREAAIDQDDLDGKKIYPDIDPAILDELKEYGTVISARRLERQVPPTLARVDELERYTQISSHPLHMMNKPGILSMDIHPLKPRLLRSRTMPLPSAAARAPPSGTPPWPYREVAEARGAELLVREVRKGVEHEGLDQKAADLAKGRQPLAREPDPRRRSRGGRPPRSPPTRSACFAWGPTAPISAVLQRLMRAFLRAGHLEDALHLFVEMLDEASIWPD
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MEEEEVNVEDFWKEYYNIPLSTLLFKCSGIIPLFVCQHQGDGKHREIIYRCKTCGIDDTSCICSTCFSKGNHEGHDAYAYATAGTFTCDCGNERAWKRSGFCSEHGNQFKGNVVEQIPLEFKGIEIVLEKMINEIAIQSQKEMNSKVQKILIVINALTSCNLFFLLFADICNKNIPNFIHSSIKEKLNKKSISYFEYFFELCFTRGVGCENLKEFLTKYMTELHLFKFSPEIIYQLSIDSISGSFNNEKLVQDLTFHFTNSKDDYIKYYFKSNRLEHTLDLMCTLFTKIFCGKKILYEQEYCNSLKTTNLLSDNFNNFLFWFIVEHPKMPVVDFTDIIYNKFIQALSLCSNSLPILIKEGTHVEYDNYYFDSTSYVTENSIEIIEAIVDTASINSLFSHFPLIHSQVMKSVRKYLVNVPIINVEDEQIHLRLCGKNQPVSPLSPLLNFYCEVLLHLNKNNKKPEISNEDALLLIEHVILSQVFKEQYINGDWVRNGGEAEQQFYYYVSPYYFQPILLDLTLVQLLLSYVSPKQFFLTSFVMFNLLGINLSGIDLTKKYHLSDLQIESPYQVTGFIRSLIEISREQTITSNLSDSEIFQQMILHFTAAGISAPSLIVQQTPYDSLPLERNYDVVCEKKGIIKKKLLSQINPVYPLFGQIHRESLIKQTIFNNKSIKSNRFEFGFKDELVFDGIKQLLKSIWVYKFFVQLIQKLNTKNKNCICDSIELGMLFIHDGYHFHLFESNEFLKNEEFKEVVKAIGYFIGIHRNELPGSKEFVNEIKSYLLEGFSSVPEHAILQNDIEVKEKPKMKKQEMKKKILLLMKKKQELYHKSIEKITENKNDECVICQMDEQNPMGRLIFLSGNGGVEIQRANEGGKTFAPLNVTTCSHHVHLKCFEEMRNERSTCPVCVNNYSHFMPLSRSIIQNGKTKEFIKESFKSILEIEIEDGNSFDAITWCIHSTISSIELALRSGISMNEEDKDLIYSMFLAIQILSEEYESNKKFIIDKIDLVDPFFAYITLKAFKEPTEIVHKSQVRGALAVIASKEPKLLKGRILEKFSKKKLECVECSEFDNINTLQEAINKLCETYQTSINLLNKCINEKEEKINFLQYINEASNIYALTIPSISHPFEFKHLPKTILKLVNKYSIEKCCNCHETDGDVLTKKICLNCGCLVCNNCFTEHRIICTNGFGIYLDVSHGAVCLSEDDIEKGIVVYENKYGDNFTATTIQQSEFLLQNDKYQQFKNAFLRGSILQSSLFIEFSETNLEPIFANQLGEILSEEEPQILQTQNVDETEANNNENPNSSN
The following text describes a protein:
Function:
Translation factor specific for subunit 6 of the mitochondrial ATPase. Required for assembly of the CF(0) component of the ATPase (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MMGRVNSQLLRVVQDRSVANGEKLQRLYKLISATGSKTATATTTATTTTTATATGGGRVLALDSHVHRWFNTHVRGSKFYSHYHFLIKHGVHLAHATRFFNKLLTGSEVEFQLATFQIFLINEENQQVFFEKFHRLYTFDMMLQIFDRLIARRDFRYVKFYLAALTRKMSELATDRTRTVQDAELMYIKFNNSLLYYLLMEGNVPMFLRTFKNEVEYIKSSTLQNSDSAEVQQALLKPVHLFVQMLRKNNSPDLIFELLPALQTKSRSKVFNAYLTSTVASTIRTFNDPTLMLKFLLTTAKGTKFPELLNELGLWRYIVHGEPGKIDPKSLQEDRDKFEKANSVSALKAMKRVDVVLLTELYRVFLSYSSSVMSPDKFRHCCIDLYSHYVQFCEQNKHKLRGWKFDTGVLNVILYHIRYRLRDDKLAYEVLVDFYGRESMVQSVKNTAKKCPFSMVIYDNGTVTTQQLHALLQLMQRYNVPLSFQICYTMVKRLLQMNEPEQAFEWYTRILESGFDVRHHGLVELVLQQGWSLPHHFNHDLLEDDKLDSIIEEEPTEECAELVEDVKELMQSV
The following text describes a protein:
Function:
Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.
Sequence:
MSAEVAAVEIQEAPVAAPIMYKVESNDGTVFEISDEAVKQSNTLSNLISTCAPEDVASMDPIPITNVTGNILKMVIEWCEKHKGEALPVDDDSVPKHITVPEWDTNFLKIDNEVLFDLIVACNYLDVPGLMNYGCKMVAMMAIGKSPDELRIIFAIPTDEEDEAAERAAKEKAEAEKKANAEKDAAEPSTSK
The following text describes a protein:
Function:
May be involved in the transcriptional activity of NFKB1. May regulate WWOX role as tumor suppressor.
Subcellular Localization:
Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass membrane protein. Lysosome membrane; Single-pass membrane protein. Note=When overexpressed, localizes in the nucleus and perinuclear regions.
Sequence:
MKSLHCVGLYLLSLLCQLTEAKKHCWYFEGLYPTYYICRAYEDCCGSRCCVRALSIQRLWYFWFLLMMGVLFCCGAGFFIRRRMYPPLLVDEPTFNVSYTRQPAGPPGGPQQPVMPYYSDPGGAMGNPMTPSFYVQPNSPQGNPPFPPPPSYCNTPPPPYEQVVKSYK
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAERDIEGVPQGLPTPGSEAEGSNFTPYCVKNECDLSSTYTETCSRIQSLDAVELGSELRLGFPCVKRENEKNHSKSNQHSDLQSFHDTELHSIKTESEPSLVSDYIKMEMNELEAVDTADSVGQKISDRQNDPGSGSVIKSEPEPGTEGQCVLQSVGPGEGLSAGSQSPEPSSTPTPSTLSVSTSTVETPGDPADCHRCAQCGKSFAILWTLKRHERIHTGQRPYCCSQCGKSFSQSGQLKTHQRIHTGERPYSCSQCGKSFRYLANVRSHQQTHTGEKAHCCSLCGKSFSTSGVLKRHQKTHTGERPFCCSQCGRSFCTLAYLKTHQQTHTGERPFPCPLCGKCFRSLKILKMHQQIHTGERPHCCSQCGKSFSSSGNLKTHQRVHTGERPHCCSQCGKSFTTSGNLKKHVQLHTGERPFCCPQCGKSFSNVETLKTHQRTHTGERPFCCPQCGKSFSRLEVLKVHERIHTGERPYSCSRCGKSFSAVGHLRTHQRTHTGERPFCCPQCGKSFGDSSHLKRHRQIHSREAAGRTAGVSPGAEPQGCGLRS
The following text describes a protein:
Function:
Plays an essential role in spermatogenesis. May be involved in the anchoring of the sperm head to the tail during spermatogenesis by affecting SEC22A-mediated SUN5 and NDC1 transport and localization.
Subcellular Localization:
Membrane.
Sequence:
MSVVKSIELVLPKDAVYLAGCIIEGQVVLTLNSTLVDPIVKVELVGRGYVEWNEETGASRDYSREVICNNKADYVHKTKTFPVEDNWLSAGSHTFDFHFNLPPRLPSTFTSKIGNIFYFVQASCMGREHILAKKKIYLMVQGTSSIFHSEKSLQNPLFVEAEKKVSYNCCSQGTICLQIQMEKNTFTPGERDIFTTEINNQTSKCIKTVIFALYAHVHYEGFTPNAERRSRVDSSELLRQEANTHITAFNTTKIVSTFHLPPVLSVSGSGSQDSEIMNTQYELVSTVHLPWTLTSVKAKVPIIITSNPVDSNQTAAGCRTRAPLPVSPDQQN
The following text describes a protein:
Function:
Required specifically for chromosome disjunction during all mitoses; maternally provided protein is sufficient until mitosis 14 then zygotic protein is required. Involved in formation and/or maintenance of epithelial structures: bud extension during Malpighian tubule development, and foregut and hindgut morphogenesis.
Subcellular Localization:
Cytoplasm. Note=Cytoplasmic during interphase and distributed throughout the cell during early mitosis.
Sequence:
MSTDIATQLKGSRSDVEKVRKTVEAKFRELSGDGLPLRYEVNVLRHICLALKDNLHQNSDLYCDIMGIMLPRVVPCEEKPSLWEAHLSSLRYIHHGLFHQRSIEACQKLYNLIRQQPCRLQEESDYKIYLDIHLTHFNGFHVLLQKQKLPLEATSQLCYALESLGDLFAAMTQRQISLCATLLVQLNESLFGKRSRSFFKSLSFLPSESLAKMFNALLMLLASSTSSNLANLFPECLSLTLALVQIDMFSPQSNQQMSLQLLRMSKELFRQESNLCYALQLMYYYIKLIFVREPTGDFKRTYIDLSSKFQHFFEHKVASHAKEQWLADFLVAIQLLQVLIHQSNSKLQSPFQIFWQQFDGESSPEIYTAHFQLLQTCASLAVNITRSPLGCSCSHEACKSVRRHCILAYGLCALDAYINWKPAAEQRANVSPHKPLLGVVKYSMDVAKTMKCLGPTSVEIIKLVRQLTYVADQVTCPEQMSVLLPLLEPLQKLRPLVADQDMSSLLRRLFKASSHCGDSNIACRIQASYLASITNPARLRSQVCLYYHNLGKKGTEIKRCVYEWHESTPLPFPLTPDQKKQLYDTDFFALLHYLRSPSTAHMESLIRCRTSDYHLVLLARQMRKDDSISKKCIEVHDKLRQQRSLSRMDNLCLGHASVGLLLDALEAQKTKVSTKEITENMFEELLLSKNLWQMNIQREQRLVNYASEAISAFSNFFDRADQEPLSANETSIDWEALIDDAIATANALSSMGYQSEEDDAWLLLLRMGRLLEDRFTYLRALNHFLSQNEVSSRLNLKLGEEVEVAEELLDDLWPQLKNGKFFKRQQTTVMLCFCHLASYYARMECYSHAQLLLLHVEQLREEFPERQGKSDIVLLTLQTVRFRIGYQQRKPTNCRLPTPLRQLDILLDNVRSFCNLSSLDGGSLQLLLSTLVRESTECSANRLSERLSFSNIALHLVLQSGLALRAIEVFLAWLWTNLQMESFDKAQSKLRLIEHCLGIKQLNPTSRPEKEAIKDVAISDLASNMHLLQLVEPIRKQQLLNMASPNLLKMRPHSPNPQLDLDRYITLDVAPANLRENSQLQCLYFVTGCLHARLRFLQRNSEQLEEFYGRAHNWMQEKPPMSSALYPMLHAQQLYHLNYLRFARKHVEAISTAQLGLKMRSRAVDINFEYNFLAQLKTAQLELKPVGQDKPQVKILRRALVFNHSPEDKKRTATGSVSAVKNTASKVKQSAKKAPRFRIYEELELRPPSATSCSSSGGSGTENTPPSDHVDLNACQAIEISDDDDSPLVSTKKTQPKSREKAKPKATSKACKVLTLDNSLEIVETPTITTSTRSTRARLRQPVETPKTATLSSKRTRRQVLEAQAPETESISTRTRHRH
The following text describes a protein:
Function:
Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase; Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
Subcellular Localization:
Cytoplasm.
Sequence:
MATTTTTTTRSGGRSCVWARLITQPTEAPVEEESALEALDRYIHRPHLINRRIGGTETRYSANSLSPSQVVEKLRAADPEAGVPENFAALLELRRSCDLVVVHHELRATTATNPLSSYCEALVLDAASQRAWLCPLSNHPATFACVRLTWGKSTAEGQTADARGAVTYEVLLDSEAAEPARPCGSPPYTLLAQADVEAPTFPSSHWFLTKFVPKFTSWLAAADGPASELSRWRPTPETMLVPPAEYARLYRELRDKYGPALVESWTESTDPEKFVYEDIGIATFLILLFRRVAELEAEQGQAPANFTYKFVDLGCGNGLLCWLLAQEGFRGLGLDLQRRRIWDRFDADVELLETAVDPKYGLTYPSCEWILGNHSDELTPWIPLVAASSTPQACSSQVLKERFLFVNDDDTHVVWASRWAGSERQKTVDKQ