lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation. The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts. ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs. ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1. Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress.
Subcellular Localization:
Cytoplasm. Note=Translocates to the mitochondria upon exposure to hydrogen peroxide.
Domain:
The VLRF1 domain mediates binding to the 60S ribosomal subunit.
Sequence:
MAKPAGDAAVGSRSGELFLPSVSSSATSPAPSAAPAPASVSLLSLNGEAPLIRGLSLVSQAPGEALAWAPRTSCPGENTSSGGKVSPYSLEISEKLFCSACDQIFQNHQEQREHYKLDWHRFNLKQRLKNKPLLSASDFEQQSSTGDLSSISGSDDTDSSSEEDLLPLDEGRAESEKPNRPPGFYPHRVLFKNAQGQFLYAYRCVLGPHQIPPEKAELLLQNLQNGGPRYYVVLMAAAGHFAGAIFQGREVVAHKTFHRYTVRAKRGTAQGLQDAHGRASRSAGANLRRYNEAMLYKDVRNLLAGPIWSKALGEAETVLFRAPRSGRSLFFGGQGAPLQRDDPRLWDIPLTTRRPTFGELQRVLHKLTTLQVYDEDPREMVRFHSPETHWKPVREERKKDTEKEKTKVPSDANKPLGQDEEPLKQGSESQEEDGSEVELELVELTLGTLDLREFEVLPKRRRRRKKKERSQEQQCGAHGPLPQQPQDEPFSQPTQEVETPLDTLVYEAKAPGQPELWDTLLAACRAGEVEVLKLQLATGLVDPGVKSLLNAPLGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNLDAYDYNKARVPGPLTQEMEARQATRKKEQKAARRQREQQQRKQREQEEQEQEEQRRFAALSDREKRALAAERRLAAQLGAPSPPVPDSAVASAGRCWSCGVSLQGLIPFHYLDFSFCSTRCLRDHRSQAGRPSS
The following text describes a protein:
Function:
Orphan receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDTTMEADLGATGHRPRTELDDEDSYPQGGWDTVFLVALLLLGLPANGLMAWLAGSQARHGAGTRLALLLLSLALSDFLFLAAAAFQILEIRHGGHWPLGTAACRFYYFLWGVSYSSGLFLLAALSLDRCLLALCPHWYPGHRPVRLPLWVCAGVWVLATLFSVPWLVFPEAAVWWYDLVICLDFWDSEELSLRMLEVLGGFLPFLLLLVCHMLTQATACRTCHRQQQPAACRGFARVARTILSAYVVLRLPYQLAQLLYLAFLWDVYSGYLLWEALVYSDYLILLNSCLSPFLCLMASADLRTLLRSVLSSFAAALCEERPGSFTPAEPQTQLDSEGPTLPEPMAEAQSQMDPMAQPQVNPTLQPRSDPTAQPQLNPTAQPQSDPTAQPQLNLMAQPQSDSVAQPQADTNVQTPAPAASSVPSPCDEASPTPSSHPTPGALEDPATPPASEGESPSSTPPEAAPGAGPT
The following text describes a protein:
Function:
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Subcellular Localization:
Nucleus.
Sequence:
MLNSVFNQLTGLRASRPNSSLKNYISPNPIPYSRKPIPKKKEKKKKQETLTIVRSSAQTSTVAPTAESIGPFCSVHRLRVRLLGEVTFISTMQLEEKVPSGDESNPCLSKSTRLPRKRFYRARAHSNPLSDSHFPVPTSPLHVDYSLHFPHFFPSPDSQSSSKKVEFADIGCGFGGLLISLATLFPDTLMIGMELRDKVTEYVKERILALRVSNPGQYQNVSVVRTNSMKYIPNYFEKAQLSKMFFLFPDPHFKERNHRRRVISPFLLDEYAYAIKPGGIIYTITDVEELGE
The following text describes a protein:
Function:
Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides. By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow.
Subcellular Localization:
Membrane, caveola. Membrane; Multi-pass membrane protein.
Sequence:
MRGQLGADVDGNSLWHEGAVRPEAGVADPRWIVRKGPEHEGLKGLLRPIWCQPMFFIWVRGGQQVGGGEGSLEASQQVTDNWLLPEAPQGMHRGVSSFRGAGTAAKMTSPPLGADDAIPLQSAAPAVTGTKPKMSTTRKILLILGFLSTLAAIALITVAVTQNQPLPKNIKYGIVLDAGSSHTNLYVYEWPAEKENDTGVVQQVEVCKVEGPGISGYSQTTEKAGPSLVQCLRQAEGVIPLKQHQETPVYLGATAGMRLLRLENKDAAEKVLSSVEKTLRSAPFNFQGARIISGQEEGAYGWITINYLLGNFKQSGWKKFLHSLKSVSETSGALDLGGASTQITFVPDEISSESPQNLLYFRLYGKDYRVYTHSFLCYGKDQALQQKLARDLQSTENSSLFDPCFHQGYQRTISVSNFFKNPCTSVEKKQFPFSQLHIEGEGNYEKCRRNIQNLFNKTDCPYSSCSFNGIYLPPLQGDFGAFSAFYFVMNFLNLTSDDPFTLDEVASAIKKFCARPWHEVKLQYHQIKEKYLSEYCFSGAYILSLLENGYEFTTENWKRIHFLGKIGSSDAGWTLGYMLNLTNMIPAEEPPAPPLSYGSYVGLMVLCSLVLVSVILLAWLLFHKPKCLQKGVV
The following text describes a protein:
Function:
Required for fusion of ER-derived vesicles with the Golgi during ER-to-Golgi protein transport, probably by mediating correct membrane localization of ypt1.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MAYYNNPANLQYYDYSYTADNSFNTQSRAAGFYDEPLHEPLSQGWLAAFSTSGYPGEPSLLEELEINFGHIKQKTTHVLNPFKHVDVHIMDDTDMAGPILFCLLFSTFLSLHGRSHFGYIYGIALLGSLSLHFVLRLMSAKNLFFTRTVSVLGYSLLPLVVIAFFKNIFTFNGIAGYALAALACIWCTYAASAMFVGILQVNNMRFLVAYPIALFYGVFAVITVFSK
The following text describes a protein:
Function:
Accessory component of the DNA polymerase delta complex and possibly the DNA polymerase zeta complex (By similarity). As a component of the delta complex, participates in high fidelity genome replication, including lagging strand synthesis, DNA recombination and repair. Required to recruit the DNA polymerase delta complex to the nucleus of rapidly dividing embryonic cells, and as a consequence is essential for genome replication during the earliest cell cycles. Increases the efficiency and processivity of DNA synthesis of the DNA polymerases during mitotic DNA replication and repair. During development this function is essential for preventing replication stress that results in the formation of chromosomal fragile sites (CFS) such as chromosomal breaks. Ensures genomic stability by promoting several types of DNA repair mechanisms including repairing broken dicentric chromosomes through homolog-dependent break-induced replication (BIR). During homologous recombination (HR) repair, required for maintaining the processivity of the delta complex during break-induced replication; a form of HR that requires extensive DNA synthesis such as the repair of large gaps. Able to suppress position effect variegation and may therefore have a role in the induction of chromatin state changes that likely include its activities in DNA replication and repair.
Subcellular Localization:
Nucleus. Nucleus, nucleoplasm. Note=During oogenesis, detected in the nuclei of nurse cells, follicle cells, and in the nucleoplasm of the oocyte. In syncytial cell cycles, accumulates in the nucleus during interphase but disperses into the nucleoplasm at the onset of mitosis.
Sequence:
MSLKKALDDCMIDFDRCVLVTDLLEEYKLSYKEVNDVLEAYIKEQEPATKFEKRFLVHGKRKTQGSDSGEDLYSVVLESRMQDWLAKVQDAESQLYSVKIAGGTKAPAAIFKPMQHLEVKLAKVEQRPGAGKIVPSANGTTPHNGVKSEPTKSEPSKSAVKLEPSKSSLKSEPAKSKAEKPVASKSSPEDKKTSPKEQASKAKPAAAKKGSINSFFTAAASKPKDVKATPSKSTSGTVDNFFKKQPAGAKKSPPESEDKSKKDASNSNKKEASKKKSPSPTKKPTTANTSMQLFDEESAESSDEEEKLDMLRRKVIESDNDSDQEKASSSKRRRISDSEDEEQPPKKSADEETIALDEKMDTEPANETYLDEDGFVITQRKPTKAQPANKKVSPKAAAPVNKKKSPPSAAKAGKDAPKTKQAGIMNFFSKK
The following text describes a protein:
Function:
Controls the morphogenesis of lateral organs. Functions in lateral organ shape and is sufficient to induce proliferation and growth of lateral organ tissue. Is necessary and sufficient for bract formation, but its expression is excluded from the cryptic bract, which could be a cause of bractless flowers in Arabidopsis. Participates with FIL and YAB3 in regulating valve margin development. Functions with JGL to define stamen and carpel shape. Functions with AS1 and AS2 in the sepal and petal primordia to repress boundary-specifying genes for normal development of the organs.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing JAG form bract-like organs on the inflorescence.
Subcellular Localization:
Nucleus.
Sequence:
MRHEENYLDLNNLPDDFSKDGNKQALEEGSSSGQRKKKGSKEGKDESGKVYECRFCSLKFCKSQALGGHMNRHRQERETETLNQARQLVYRNDTITPPGISPFGYHHTTDPTIYRSVYSSPMIYPGSSSTNLVPQPPMPPPPPPYPYSSNQYSPHNHFNDYYLNPSFRGSRSISPSPNLPTTTTVDYMADSPVEPGYTCVGAPIGPTGFPIRGPSIVRAPLEPPQGRDGDASRQRLDHSLRFPINRFQDHHSL
The following text describes a protein:
Function:
PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions.
Subcellular Localization:
Secreted.
Sequence:
IFNKAYRKVLGQLSARKYLHSLMHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQ
The following text describes a protein:
Function:
E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
Sequence:
MKKKYDIKTTDVETLKKWYHLMTLGRALDEKAPSYQLQSLGWSYHAPYAGHDGIQLAVGQVFTLGEDFLFPYYRDMLTVLSAGMTAEEIILNGISKATDPGSGGRHMSNHFAKPEWHIENISSATGTHDLHAAGVARAMVYYGHKGVAITSHGESATSEGFVYEAINGASLERLPVIFVIQDNGYGISVPKSEQTANRKVAENFSGFKNLKIIYCNGKDVFDSMNAMTEAREYAISTRNPVIVQANCVRIGSHSNSDKHTLYRDENELEYVKEADPLMKFRRMLLRYKRLTEEELLQIEAESKKELSAANRKALAAPEPDPKSIYDFVMPEPYQPQKYKEGTHQEEGEKTFLVNAINETLKAEFRHNPDTFIWGQDVANREKGGVFNVTKGMQQEFGEARVFSAPIAEDYIVGTANGMSRFDPKIHVVIEGAEFADYFWPAVEQYVECTHEYWRSNGKFAPNITLRLASGGYIGGGLYHSQNIEGALTTLPGARIVCPSFADDAAGLLRTSMRSKGFTLFLEPKALYNSVEAAAVVPEDFEVPFGKARIRREGTDLSIITYGNTTHFCLHVAEQLEKESGWKVEVIDIRSLIPLDKEAIFESVKKTSKALVVHEDKVFSGFGAELAAMIGTDMFRYLDGPVQRVGSTFTPVGFNPILEKEILPDEAKIYEAAKKLLEY
The following text describes a protein:
Function:
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity).
Subcellular Localization:
Cytoplasm. Note=Localizes at mid-cell. In sporulating cells, localizes near the cell poles (By similarity).
Sequence:
MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREINEKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD
The following text describes a protein:
Function:
Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. In association with the nfya-1-NF-Y complex, may play a role in repressing the expression of the homeobox protein egl-5 in tissues such as the head. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X chromosomes in germline cells. The complex may act via methylation of histone H3 'Lys-27', rendering chromatin heritably changed in its expressibility. This complex is required to exclude mes-4 from the inactivated X-chromosomes in germline cells. Required for small-RNA-induced H3K27 trimethylation.
Subcellular Localization:
Nucleus.
Sequence:
MEHTKKFKSLNLHGFDRSTEDYGKRPFVLTAKLLEDQKKAIYGCAFNQYAGIDEEQAVATVGGSFLHMYSVPIDINNIELQWSCNFPTDKSSKVEREESLFTVTWCYDTYEAENDRNPFKVVTGGTLGHIYVIDYVSRKLSNRLRSVGWEINDIRTCPANSNLIVCASSDQSIRIHHIRNEACLIVIGGLECHAGTILSVDWSTDGDFILSCGFDHQLMEWDLSVKQVKEHLERACKALHQDKINVLTQSQDIPYVSKGTMRKSAVSRNIPDKEEDQLLELHRELIPRPSCLLPIYTPSSVSTDMHSDYVDCIRFLIGTNYALSKGCGNEKAIHFWRFGPPKGEVENRIHGNVLRPKSCTTKFRTMNVPSGSAWFIKFAVDPRRRWLVCGGAGGSVMFFDLRNNEETNPTHTCSVGSRTVRQASFSTCGRFLVLVTDEGFVCRFDRVSASVDAKDLAKF
The following text describes a protein:
Function:
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
Sequence:
MAKLAEEMNPEGSRYQLLLSCPSGLSPSQVSVDFSKSHDRIPRQDPGLEDSISQVWEQRSQGNSSLFNGQKFRYGGYCLDDDDGSTNEVPHVCLRLGLTDYRTFVGTNLSSLWEKFLVTSEDDSVRCRHTSSPLGNGAVIETSDKKIIVLRRSNNVGEFPGHYVFPGGHPEPTAVGIDYHQLENNVQTGEVLNKKVTQEMFDSIICEVVEETGIPASSLSSPLFIGISRRELNVRPAMFFYLKCSHHSDDIQRLYSSAEDGFESTQLHTVSLDELKMMTSRMPGCHHGGFALYELMLQRLKNTKETSLIAT
The following text describes a protein:
Function:
Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MLLLLPILNLSLQLHPVAALFTVTAPKEVYTVDVGSSVSLECDFDRRECTELEGIRASLQKVENDTSLQSERATLLEEQLPLGKALFHIPSVQVRDSGQYRCLVICGAAWDYKYLTVKVKASYMRIDTRILEVPGTGEVQLTCQARGYPLAEVSWQNVSVPANTSHIRTPEGLYQVTSVLRLKPQPSRNFSCMFWNAHMKELTSAIIDPLSRMEPKVPRTWPLHVFIPACTIALIFLAIVIIQRKRI
The following text describes a protein:
Function:
Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase (By similarity).
Sequence:
MEDLEEDVKFIADETLDFGGLSPSDSREEEDVAVLVTPEKPLRRGLSHRSDPNAVAPTPQGLRLSLGPLSPEKLEEILHEANRLAAQLEQCALKERENTGEGSGPRRVKPSPRRETFVLKDSPVRDLLPTVSSLARSTPSPSSLTPRLRSSDRKGSIRALRATSGKKPSSVKRESPTCNLFPASKSPASSPLARSAPPVRGKAGPSGRATASPPTPVRPVLAPQPPAGSSQRPSRPQGAAAKPSSRLPVPSAVPRPGNRMPLASRSVPSSKGAPPSDSLSARKGLPRPSAAGHRVPVSQRPNLPISGAGRSNLQPPRKVAVPGSTR
The following text describes a protein:
Function:
Major determinant of cell surface composition. Negatively regulates motility, adhesion and synthesis of biofilm exopolysaccharides.
Sequence:
MDHSLNSLNNFDFLARSFARMHAEGRPVDILAVTGNMDEEHRTWFCARYAWYCQQMMQARELELEH
The following text describes a protein:
Function:
Acts on androgens and retinols, i.e. has steroid 3-alpha- and 17-beta-dehydrogenase and cis/trans-retinol catalytic activities.
Subcellular Localization:
Microsome. Endoplasmic reticulum.
Sequence:
MWLYLVALVGLWTLLRFFRERQVVSHLQDKYVFITGCDSGFGNLLARQLDRRGMRVLAACLTEKGAEQLRNKTSDRLETVILDVTKTESIVAATQWVKERVGNRGLWGLVNNAGICVFAINEWLKKEDFANILDVNLLGMIEVTLSMLPLVRKARGRVVNISSSMGRVSLCGGGYCISKYGVEAFSDSLRREISYFGVKVAIIEPGGFRTNVSNYERLSHSIEKLWDQTSSEVKEVYDKNFLDSYIKAIQSLTDTCSDDLSVVTDCMEHALTACHPRTRYSAGWDAKLFYLPLSYMPTFLVDAMLYWSSVKPAQAL
The following text describes a protein:
Function:
Counteracts the antiviral effects of host IFN-alpha/beta and key IFN-inducible proteins involved in viral RNA degradation suxh as host OAS1. Acts as a soluble IFN-alpha receptor and thus inhibits the interaction between host IFN-alpha and its receptor.
Sequence:
MNDNMRDLEVMRRLVFLLISVWSVLGNETMTEATDCLADLDSNKLSFLEETAILVFSPECQHRVLQCRSVNFCSIQWFFNDIPYDSWSLGNNSDTKYKLEDSNQTLNFLSTDVDAGGTYTCVVSNGVRNITRSINMSIEKRPWINKPIPFESSSAVCKDQMAVLGGNASFFCQFKYRNDLLLQYNWKKLNQTNGIYEKVDFYDIHGTEFSYGSRKEDGNVTQTQTCQRKPLKILSTWLNITNVTEEALGRYQVMCKISQYITTVNLTLSLEEHVVTVTDTTSVVVVIATLIILLSLFVLSWKRYGTDVKLWYHDHRTTLETEEIDNKLYDAYIISCYEGQDKSFVDTILCPSLQDQYKLFIRERDATFGSVESEEIVEALTKSRRCIVLLSADFYRHSSISSSQSTSGMINTTAVQLTSSSSSSSSPSSPSFSGNDLSGNEWHLFELHHALDTMHPNVIPLLYRDSGPTSLSNTDSNAKLIDHVLKDVTCLKWKQKGETRLDDWAMKRLRLRLPPRRRSSNLPSEQSSYITMPVMSAATPSNISSSISLTSPLLLTAERPYAVDSSLQHLTALSGPESSSSGGIVNGEALDSSRPEPSQSPELSFMSMTTSPPLSPTAPMSRPEPSQSPELSFMSMTTSPPLSPTAPMSLSSSYGSCSITSPDSQGTSQSPSSPCTSSSLFSPSHLVHANETDNLNSFQEYQPDSNTFNSSLSTFQFFLRPKTGPNLIDNESKPGYI
The following text describes a protein:
Function:
Required for normal Golgi function.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MPLSVPSSWGGSFPSPQEAANVRPSLAAPEKQPAAAGVTDGVAPAAAARTSHAPPSLPTPSALAQPQPPSAAARPTDAEPPSSAAPASAFSTSAKSNATQRKVARLLDITTSSEIKDLASYVDNILPGYFYSLGDSAKDESSSADVAAASGHRSTPAPSSAASSHSNNNKTITSTALRSALDHRTIDVHKSFLQEFKAVYQSYQRVAAQVNELQSKCSSLEDTLNTTAGCPSREVEDFFYQIQAYQAELQLVQSHDKEVDEFRKQHHFGAAEQKVLEEGAVDMNFLNALERARQVHQRSSELMQSQEYHQGALAVMESTYGAITRATEKIARHLLSTAGSGEGRRAGVVASAAAGSARSIAADVPEVTGFQLRCVRLLYEESPSLHDKFLDEVARLRRASVLRRYFHLLTTGSANTSTGLYQSGVQPSAHDGGVGRRHDSSEAGMGARPLEVELNNPTYFFSSLCAWLHQTIAEEQDFIHNFFGSDEPEVGRRGRRSHAATAAPSPSCLQSGSDAARTAHDKTRQQALLDGVFGGVCKHIRAALDSVLERLERTAAVLGAATGGLEGEGRAGGCGSIAIAGSADALAPRKGPRGLTGGLTRLFMAATGRSPIAAFRGAGQDESNALLQRYAGVTTRAQQEAVASSMLRPLLQGIQTCVTLVQLFEYYTATTFAPLLGEASALTQLIHKAAPEKTRELFQRLLHVLAVHLLDSTAGIIGRTATLRRLASSHALKQAADGDDAQGVSPLATEHRAVTKTGPSTFVLDFLVAFTYGIDANGLGGAPNGSESALLNDTESGVHMSFPSHSAAATTTRFRQANDGQLLHHSAHDLRRVLSQLILPPSPEVAAYCAVVHSVLQDTARQVELLGAIAEQQRAAVAQGHRSSGPTAASDPGAAALATHTEVTFFVQEMLQSLLKAARSVETDGPLRTNLDDPCRAIVEYNVLYKLRDVLEQHAAVLSVLFKGSDAQGPEAEQTLDSIRMECAATMTTLRRRLVSAWTTAVKLFYFPVSAEAVVAAMSSAAAAEANEKQLITVKKDVRRVLKQFVNVYNTIASLGHLPEPVPLLSALAGSDDVCEEVRRKVTLSIVEDVYTAEFKMLSAVPPTEELVAVQTEMAPQNLLKLVDFSSPAPAATLQPLSS
The following text describes a protein:
Function:
Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond.
Sequence:
MAPVLLHGILDLTIFEVDRLSGSGCSKFFCKILENVEETVGCGKGFSKLYATIDLEGTKVGRTRELKHARSDPQWDESFHIYCAHLASNVTFSIKVKDPIGSQVIGRAYLPVVELLNGEKVDKWLRILNKNHKPLHRGLKIHVRVQFLDATKRSSWSKGITSPNFSGVPYTFFPQRSGCRVTLYQDAHVPDKFNPKIFLRGDKRYAQHRCWEDIFDAICNAKHFIYITGWSVFTKISLVRDSRRPKKGGDTILGELLKKKAEEGVRVLMLVWDDKTSVKLLKKDGVMATHDEDTRSYFHNTRVNCVLCPRNPDNWKSIKQGLEISTVFTHHQKTVIVDSGLPNGELEKRRIISFIGGIDLCDGRYDTQFHSIFRTLDSAHRNDFHQPSFSNASIAKGGPREPWHDIHCRLDGPVAWDVLTNFEQRWRKQGGKEELLLQVRELKDIFVPRSLAMFPEDNETWNVQLFRSIDGGSTYGFPDDPEAAARVGLIKGIPESGSVQAILKWQNKTMEMMYSEIAEALQAKELDSNPKDYLSFFCLGNRETEKSGEYSPPEKPEHNTDYRRAQEARRFMIYVHAKMMIVDDEYIIIGSANINQRSMDGARDSEIAMGAYQPYHLSTRQAARGQIHGLRMSLWYEHLGKLDDSFYHPETLECVRKVNQIATKYWDLYASENLEHDLPGHLLTYPIGVDSNGKITELPGIEFFPDTKAKIFGSKSELLPSIITT
The following text describes a protein:
Function:
Receptor involved in axon guidance during development. Acts as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 repulsion, inhibits SLIT repulsion, and facilitates Netrin-1/NTN1 attraction. In spinal cord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1/ROBO2. Binding OF NELL2 to the receptor ROBO3 promotes oligomerization of ROBO3, resulting in the repulsion of commissural axons in the midline. ROBO3 also indirectly boosts axon attraction to NTN1 without interacting with NTN1 itself (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MLRYLLKTLLQMNLFADSLAGDISNSSELLLGFNSSLAALNHTLLPPGDPSLNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPDLEPGLEVGAGLAVRLARVLREPAFLAGSGAACGALLLGLCAALYWRRKQRKELSHYTASFAYTPAVSFPHSEGLSGASSRPPMGLGPAPYSWLADSWPHPSRSPSAQEPRGSCCPSNPDPDDRYYNEAGISLYLAQTARGTAAPGEGPVYSTIDPAGEELQTFHGGFPQHPSGDLGPWSQYAPPEWSQGDSGAKGGKVKLLGKPVQMPSLNWPEALPPPPPSCELSCLEGPEEELEGSSEPEEWCPPMPERSHLTEPSSSGGCLVTPSRRETPSPTPSYGQQSTATLTPSPPDPPQPPTDMPHLHQMPRRVPLGPSSPLSVSQPMLGIREARPAGLGAGPAASPHLSPSPAPSTASSAPGRTWQGNGEMTPPLQGPRARFRKKPKALPYRRENSPGDLPPPPLPPPEEEASWALELRAAGSMSSLERERSGERKAVQAVPLAAQRVLHPDEEAWLPYSRPSFLSRGQGTSTCSTAGSNSSRGSSSSRGSRGPGRSRSRSQSRSQSQRPGQKRREEPR
The following text describes a protein:
Function:
Inhibits E3 ubiquitin-protein ligase activity of COP1, a central repressor of seedling photomorphogenesis. Represses COP1-mediated turnover of HY5 in the dark. Required for primary root development under normal light growth conditions.
Subcellular Localization:
Nucleus. Nucleus speckle. Note=Is recruited to nuclear speckles by COP1.
Sequence:
MPPKRNFRKRSFEEEEEDNDVNKAAISEEEEKRRLALEEVKFLQKLRERKLGIPALSSTAQSSIGKVKPVEKTETEGEKEELVLQDTFAQETAVLIEDPNMVKYIEQELAKKRGRNIDDAEEVENELKRVEDELYKIPDHLKVKKRSSEESSTQWTTGIAEVQLPIEYKLKNIEETEAAKKLLQERRLMGRPKSEFSIPSSYSADYFQRGKDYAEKLRREHPELYKDRGGPQADGEAAKPSTSSSTNNNADSGKSRQAATDQIMLERFRKRERNRVMRR
The following text describes a protein:
Function:
Antibacterial peptide mostly active against Gram-positive bacteria with atypical up-regulation of expression.
Subcellular Localization:
Secreted.
Sequence:
MKFAVVSFLLVALLGLVAVGEAQLKNLACVTNEGPKWANTYCAAVCHMSGRGAGSCNAKDECVCSMT
The following text describes a protein:
Function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
Subcellular Localization:
Cytoplasm.
Sequence:
MLLGLGPGAIERKAPCATRSPSGMLPVRVPLAPLASKQPPQPSLRLSPMKGLHLADKENTPPSLNITRVLASKTARKIFQEPLESVVTSITPIIPASPRVEDEPLLKENPRRFVIFPIQYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEEKYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKEPKEREFLFNAIETLPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVKEIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLLLELGFSKIFKVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSSTENSFTLDADF
The following text describes a protein:
Function:
Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. May play a role in cell growth (By similarity).
Subcellular Localization:
Secreted. Cytoplasm. Cell membrane; Lipid-anchor, GPI-anchor. Cytoplasmic vesicle, secretory vesicle, acrosome. Membrane raft.
Sequence:
MAFLVALLVVLGLQLVQSNALTCHVCEAQNSYACSNPSQCPGEKKFCLLAVTRIFERFFYVSKQCTRRCPTPVVSPPSTNPPSEPKEFLIEKPMPFLFYKCCQWDSCNGEGPPTDQLLKEQPGKASGRRHRYIELLLTGFMVLTANGLSALCLL
The following text describes a protein:
Function:
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
Subcellular Localization:
Mitochondrion outer membrane.
Sequence:
MSETRKDTDRASAQLPTKCQLPERVAVIGAGPVGCLAALAFAQRGCKVDIFESRPDPRTHEAITRASQRSINLALSTRGITGLRSVSLAGLGVGTNAPNGMDLADLVLQNSVPMRARMIHVVTRQASATQAAEVKEISQLYSTKGESINSVDRGRLNNILLEHALMHRNVEVHFEHKLQSVDFDHDIKSAAKRAGTPPPAIDASANKWLRGANVTGGDSCADEPSGCGGRKQATTKSQGSEYVAPAGTSAVDRVRLDFDVHSTNQHIRKTSNTHYASFVVGCDGAHSSIRSAMGSLIRMHYTHNYIDTGYIELSIPPRTSLGSGSRIRGSGGVDGKRGGHDAFHLDANHLHIWPRHSFMLIALPNLDGSFTCTLFAPFKMFASELSTKEGIVAVFQQHFPDALALIDEEKLVKCLTTRRASALGSVQCDPYHYKDRAVLIGDAAHAMLPFYGQGLNCGFEDVRVMFDIIDQHESLQVALDLYTKERHPDLVAILQLAEQNYREMAHSVVSWPYLLRKKLDGLLMSILPSSMWSSLYAMTTFSNLPYSRVVKTEKRQQAIIGHALVATAVAFVSAAAVGVYSTRALWQPVTVRCIARLHNS
The following text describes a protein:
Function:
Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication (By similarity).
Sequence:
MSRLPSEDTLLEVNIEDIRVSPFQPRRTFLEEDLKELVLSIKTVGLIHPPVVREIRNGDKVLYYELIAGERRWRALQLAGYKTVPVVLKQVLADDMAAEATLIENIQRVNLNPLEMAEAFRRLIVVFGLTQDKVAKKVGKKRSTVANYLRLFSLPQEVQEKMNSGEISLGHAKVILSLEDENLRQILSQKIISCKLAVREAEMEAKRLVKGKGASLKEDSSSQPSSRLGFCQERLATTFGYPVTVKPQGRRICVSFFVEGEEALEALEKALTTSSSEAILT
The following text describes a protein:
Function:
May be involved in transcription regulation.
Miscellaneous:
MISCELLANEOUS: Present with 2360 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Nucleus, nucleolus.
Sequence:
MADINKYIPMVDAILSVSNPDEISPKRVRKALQILYSVNLDSQRKLINELILERFGDIQENPRVLIPKNDLISRDQELSLRLQKEEERPLRSTRKRKGKSESKSKRKKKKNDSPDSNSISVRKVLLSAPLQKFLGSEELPRTQVVKMIWQYIKEHDLQNPKDRREILCDEKMEPIFGKKMTMFSMNKLLTKHLFNPDEIVKHEEEQKQTPEKEIKLENESLPNLSG