lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MNPLTKVKLINELNEREVQLGVAEKVSWHSEYKDSAWIFLGGLPYELTEGDIICVFSQYGEIVNINLVRDKKTGKSKGFCFLCYEDQRSTVLAVDNFNGIKIKGRTIRVDHVANYRAPQESEDVDDVTRELQEKGCGAKTPPSSPPEVSEDEDAKVTKKPKKDKKEKKKKKEKEKTERPVQAELPSCSRSKTVKETDEQSAKKHSSKPSERAQKSECRERKKSHSGSPDGRTSCRGRAEEPEWEAKKEKHKHEHKPSSRREGEEKSRDKDRGRSSGTHSSRHHGHSEGRSHRSRSRSRSRSPDRSHRHKKHRYSHERESFHASDRRHY
The following text describes a protein:
Function:
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.
Subcellular Localization:
Cytoplasm. Cell projection, lamellipodium.
Sequence:
MGQADVSRPVNPDAVEEAERPSGDPGLVMDSVEAGDTTPPTKRKSKFSGFGKIFKPWKWRKKKSSDKFKETSEVLERKISMRKPREELVKRGVLLEDPEQGGEDSGKLSHAALKNGHTTPIGSVRSSSPILSEEEAEGSLRNLTPEEDPKKRLGSTGSQPSSEAEPGPEQASKQPLLPPKRPLSSSDEGNEGQAKEVPAGSAARPVSSTSGSGIETPAATTAATDMTKTLTKSFVASTPAPTPAPRTLPAAPASTNTTATHPAPAKQPPIPPPKPAQRNSNPIIAELSQAMNSGTLLSKPSPPLPPKRGIPSTSVSSSEPAASATAKTANDQREKTVSLCLEPPLTIPPSSPSPPLPTHIPPEPPRSPLVPAKTFQMVPEVEFSPSLDRFQDISQQEDQKKEVPKKIQDQSFGESHIPSRLPPVPLHIRIQQALTSPLPVTPPLEGTHRAHSLLFESSDSFSEDTGTLGRTRSLPITIEMLKVPDDDEEEQICPFVEDMTSTSATPKLPPCLQEEEKESDSDSEGPIQYRDEEEDDDDDESYQSALANRVKRKDTLAMKLSSRPSEPETSLSSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTAEELEQRNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAQDYDRRADKPWTKLTPADKAAIRKELNEFKSSEMEVHVDSKHFTRYHRP
The following text describes a protein:
Function:
During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.
Sequence:
TAWTFLKAMQKCSKKREARGSREAPETNFPDTTEESAQQICCTRDSSDSKSVPRSERNKKGIQCQGEGSSRGSQPGQFVGVTYNLEKRPTTIVLINDTPLNVLLDTGADTSVLTTAHYNRLKYRGRKYQGTGIIGVGGNVETFSTPVTIKKKGRHIKTRMLVADIPVTILGRDILQDLGAKLVLAQLSKEIKFRKIELKEGTMGPKIPQWPLTKEKLEGAKEIVQRLLSEGKISEASDNNPYNSPIFVIKKRSGKWRLLQDLRELNKTVQVGTEISRGLPHPGGLIKCKHMTVLDIGDAYFTIPLDPEFRPYTAFTIPSINHQEPDKRYVWNCLPQGFVLSPYIYQKTLQEILQPFRERYPEVQLYQYMDDLFVGSNGSKKQHKELIIELRAILLEEGFETPDDKLQEVPPYSWLGYQLCPENWKVQKMQLDMVKNPTLNDVQKLMGNITWMSSGVPGLTVKHIAATTKGCLELNQKVIWTEEAQKELEENNEKIKNAQGLQYYNPEEEMLCEVEITKNYEATYVIKQSQGILWAGKKIMKANKGWSTVKNLMLLLQHVATESITRVGKCPTFKVPFTKEQVMWEMQKGWYYSWLPEIVYTHQVVHDDWRMKLVEEPTSGITIYTDGGKQNGEGIAAYVTSNGRTKQKRLGPVTHQVAERMAIQMALEDTRDKQVNIVTDSYYCWKNITEGLGLEGPQSPWWPIIQNIREKEIVYFAWVPGHKGICGNQLADEAAKIKEEIMLAYQGTQIKEKRDEDAGFDLCVPYDIMIPVSDTKIIPTDVKIQVPPNSFGWVTGKSSMAKQGLLINGGIIDEGYTGEIQVICTNIGKSNIKLIEGQKFAQLIILQHHSNSRQPWDENKISQRGDKGFGSTGVFWVENIQEAQDEHENWHTSPKILARNYKIPLTVAKQITQECPHCTKQGSGPAGCVMRSPNHWQADCTHLDNKIILTFVESNSGYIHATLLSKENALCTSLAILEWARLFSPKSLHTDNGTNFVAEPVVNLLKFLKIAHTTGIPYHPESQGIVERANRTLKEKIQSHRDNTQTLEAALQLALITCNKGRESMGGQTPWEVFITNQAQVIHEKLLLQQAQSSKKFCFYKIPGEHDWKGPTRVLWKGDGAVVVNDEGKGIIAVPLTRTKLLIKPN
The following text describes a protein:
Function:
Protein acetyltransferase with dual specificity triggering both N-alpha-acetylation (NTA), with a large spectrum of modified N-termini, including methionine, alanine, serine, threonine and to a lower extent glycine and valine as substrates, and epsilon-lysine acetylation (KA) of several plastid proteins.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MRSTPLGTTAVSPASIKHNSYGYGRFVSSSGVSNFSIHRRRRHSSFSISQAPSQINSGACNASQIVDLFPAVSPEIVVREARLEDCWEVAETHCSSFFPGYSFPLDVVLRVDRLMAMVMGFSIPPGCQRTCLVAVIGSSVDETICFGSDDFKIGAFDAKISLNKGYVAGILTVDTVADYLPRKGPLRQRRTGIAYVSNVAVRENFRRKGIAKRLIWKAEALAKNWGCRAIGLHCDLNNLGATKLYKDQGFRSIKIPEGATWPQPKTSPDTRFTFMMKLVNNNNTQALEQFR
The following text describes a protein:
Function:
Heme transporter that mediates heme uptake across the plasma membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTAENRGFCQLICHINVRIGWTIFGIVFGISAILTYAIKFHNWSATATTAIATLFACETLYLYWALKKNTIVNWKSSTFQLMIWPNVFIGLLGLLGCLVCYIIAGITHQGAGSIQGWSLFKCSIYFSKFAAMYGENLWFTGSWSLVITKWTWQNAFFARKYLNKIGTASEDGDIDDDDVEVIKS
The following text describes a protein:
Function:
RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells. Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs (By similarity). Sequence-specific RNA-binding factor that binds to U-rich regions (URRs) in the 3'untranslated region (3'-UTR) of several mRNAs (By similarity). Does not bind to miRNAs (By similarity). Germline-specific protein required for the primordial germ cell (PGC) survival and migration during early embryonic development.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Perinuclear germ granules, also called germ plasm or chromatoid body.
Sequence:
MVGDMDAQQQELQQILNPQKLKSLQEWMQRNSITLTQVNGQRKYGGPPPGWQGPAPGSGCEVFISQIPNDVYEDRLIPLFQSIGTIYEFRLMMNFSGQTRGFAYAKYGDPLTASAAVTTLHQYRLPEGGCLTVRRSTEKRQLRLGDLPVSMNESKLLMVLQMLSDGVEDVLLKPPGPKGKEVVALVNYTSHYAASMAKKVLVEAFRNRYGISITVRWTSFSKSKRVEDTPQEDSCVTPLVLKPLSKPSLLHYDVPAHQSLLPLFRAVGGPTTSEQRDEMIPQPTIMSRNELIPQSSIRQRDEMVPQLPIRPRDGMAPQSPISLDAVSHLQWMCEVNRLGSPQYEVHFHHAAPDGFLYFAFKVLIPGLPLPLYGFVQILPGTSARAMKSEVYRAAAEQVIQTLCRVSNLRPF
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
Subcellular Localization:
Chromosome. Cytoplasm.
Sequence:
MMAVSMTPTMERFPPKPVTNSRRSISLFSSPKVRKSIGFSNVSPALLLETPHAETGVPLDPSKSIQIQNNDEQELRERQKQRAAEMQQQNLASPSTPADRRKSMGPATGMTNAALVEHYSNCIKLSAENKINMKNAFNLQLIDCMSEMLRKKDPEMNNFQAASCTLDASAKIYAYRVDCVHIDTIKMAGGLGRTGDEGQQEQEGNGQAGGEQDEANKAKKKAKKKNKKTIETNVDHINMSKFDLEYDVDPLFKKNSARFDEGRNGGVNFLTSLMLKDDGCQLIMDSDSLCNAVSHRLEPTQTSCPVVQGKAICLDSAEICPTLKGFSFTTWDPTNDDLMGLLQSPTKRKHEEYQVPSLPTSNEDHAFDMDAVPDTYGGNDSENETHLGMEDIDEEEGIDRHRNGDGQMNPVPILAGNGKNLGIVELKDQLNRQDYSYFSVAVRSAWAGPLHWRLNKLGQKVDPNREVKKKRRKDAFVMSFEDIPDFGNDFKPAKSTSKLTNATLLQWLPEKITLPEDLHYGLKEFSQSFTRPMLSVRSSTKTGPSQDLEGILSPYDYSNRRDADNFCPEVNADSSDNDDHHDDPMTFNDQTADFASQSDGTKTFGQFSGDNLIAAPNMVAKIQINYAKVAKKMDMRRLKSTMWNMLNQPNETDNAQKPTAGNPKAFSRMYNQIPNLLPQKMAENLSVALAFAALLHLANENTLHLAQEYGNLDDFAIVHPN
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MKLVRHPCVVHLYQGAQIFTSSWSIIHVVIDVCRGFEETQRKVIPNNIRSGSSHTTRISDIHFAPGKANFFFPCADPHFGGYLPHATVWNPQMVGRVPLPLDLIEDEPVFVNVKQFHAIMRRREQRAKLETQNKLIKARKLYLHESRHVHALKRPRGSGARFLPKSFKNLESQNMTCQSNKKTPRETCMDSWLISCRSATTLVVQPHLDPT
The following text describes a protein:
Function:
Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.
Subcellular Localization:
Mitochondrion.
Sequence:
MSLILNILREMLEYFGVPVDQVLLIWENKDYGSTRSIVRIIGKMLPLEPCRRPNFELIPLLNSVDSENCGSVVPSFADILYVANDEEASYLRFRNSIWKNEEEKVEIFHPLQLVRDPLSPAVRQKETVKNDMPVNEAAIKKIAALENELTFLRSQIAAIVEMQELKNSANSSSFGLNDKPISLGQLSSSRAARLSVEPDQFPSSVLSSPPPPPPLPPQFSSLQPLCFPPIQPRSSNICDSDNPATEMNKQNLAANKTNYSHHSKSQRNKDIPNMLDVLKDMNKVKLRAVERSPGGRPIHKRKRQNSHWDPVSLISHALKQKFAFQEDDSFEKENRSWESSPFSSPETSRFGHHISQSEGQRTKEEMVNTKAVDQGISNTSLLNSRI
The following text describes a protein:
Function:
Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKRQPRRPNASLETAKTLAKDLYNFTDVLEMREFKSFFDRNFYIRGQVRTENNGNPNKPQEFVLKIHNSLDSENEEVRDAENQLMRMLRDRGFPCPEIIPTRNGQLMEKIHLPASDGQNADGCVVRLLSFVYGQELDSLDKSDVTPELMYTLGKFIGDASKAMKDFSSSALRRRQHTWDIKNFLHIQEQLASIKDDSICSLVTEVHSSFLHFVAPRLSSFRQGTINGDINGENILVTKRGTPGNPTYEITGFLDFSDIEESLLVLEVMAPMIFFMSLGYETSGYILAGYQSSLPLPGDEFDCLYYLAAARLCQLVVYSACNLENDNAQYMQVTVDKYLGILRKFWSCSKEDIEKIWRDCQQ
The following text describes a protein:
Function:
Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
Sequence:
MSFETLRAYEQTNAVCKPFLDKPSTGFALDAHIKFLESSLKPFPAPYTVLDASKTWIIYWELVSLALLGRLTDDVKEQAVHTLATFRGPNGGFTNGLGHKEHILTTYAAVLSICLCNNSEAYDLIDKKRLLDWLMSLRNADGSFRVHDEGECDSRASYAAVCIAYLVDGVNYPHLFDGTLDWLLQCQTYEGGFAGNPGTEAHGGYTFCSLAAISVLNGSSRVRRIPLARWLTQRQDAILGGLSGRTNKLVDGCYSWWVGASVNLFALEANSDSDTRPLIKSEKLQEYIYQCCQPATGGLRDKPPKPADLYHTCYCLLGLSSIAHNYRLVDNRVHAQNSSSPRYDDYPSLQPAHPVCCVPVNDAESMITHFSSLQC
The following text describes a protein:
Function:
Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MSLRGLELDYPLFVAEFLDKDHVIVGGGGGEGNHGIPNKLSIVKIKGPDMPKKISEIELSKKEDNPTSLAIFDKNTIYAGVNSNSETLKSGKNQHLRLFSLSDDKEKWSETKSSQVFEDVGILDYQKGALAVPKHKSVILSNSTAPGYIYSIDVKDHAVNFQEKTESEINGMSLSLDESKFVYVTDKTLVVANSADGKHIFNSESIKGETFSRAAFLKSSAVVAAIAVGAKDGIKLVKMHGDKFEEVSFSSYKNLKKVTALACHDKYIFTAHQDLSLSIFSADNLRLLKQYKEAHEFAITRVALNEDETMAVSVSASNTLGVIDIPADGNFGGNKLFDIIILTILILFVAIAYQKIVGTRQW
The following text describes a protein:
Function:
Potential calcium sensor.
Sequence:
MSKSRPSLHLSKVKQTPSTTSLVHFSPKLEEMKRVFDKFDTNKDGKISKEEYKSAMKMMSSGGGNTKSYEVDDAFQAADTNGDGFINFDEFMRVQSLEGGVNSTDIKSAFKAFDLDGDGKISAEELLQVQRMLGEKCSLESCKKMVRGVDANGDGLIDMDEFVTMMTRTMKLV
The following text describes a protein:
Function:
Effector of the phage shock response.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Note=Localizes at both cell poles and along the length of the cell.
Sequence:
MLELLFVIGFFVMLMVTGVSLLGIIAALVVATAIMFLGGMLALMIKLLPWLLLAIAVVWVIKAIKAPKVPKYQRYDRWRY
The following text describes a protein:
Function:
Siroheme synthase involved in methionine biosynthesis.
Sequence:
MRWLSQICEYWPLRRLASITDSDVESVLKSYATNPSTSTPLDTSILDSRVSKLPQIILAGSGPGHPDLLTRATHKAILSADIILADKLVPSGVLDLIPRRTPIHIARKFPGNAELAQQELLSLGLAGLQAGKTVLRLKQGDPYIYGRGGEEFEFFRKEGYGDRVVVLPGITSALSAPLFAGIPATQRAVSDQVLICTGTGRKGKPTVPPQYVATQTVVFLMALHRIKGLVADLTTHDSEDVKIVDENGEVDQSRKLWPLSTPCAVIERASCPDQRVVRTSLEWVVDAIEEVGSRPPGLLVLGAACEVLFNQNSRKEGRKWVTEEGFKGLNDLGLAEMGLGVCGDEGGRPDVVRGDSFGRELKV
The following text describes a protein:
Function:
Participates in electron transfer between P700 and the cytochrome b6-f complex in photosystem I. Seems to be the major plastocyanin in Arabidopsis.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Lumenal side. Note=Loosely bound to the chloroplast thylakoid inner membrane surface.
Sequence:
MASVTSATVAIPSFTGLKASTIKSSATVRIQTAAVASPKLTVKSSLKNFGVAAVAAAASIALAGNAMAIEVLLGGGDGSLAFIPNDFSIAKGEKIVFKNNAGYPHNVVFDEDEIPSGVDVAKISMDEQDLLNGAGETYEVALTEPGTYSFYCAPHQGAGMVGKVTVN
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MIRLGQNLRSISKVKLQSFNNYKYSSSNNNNNNNNINSNINNIKINEYSNLRKIIEDGQENSNRLDKLKELFPDKEDLSSPLEYLDSEQRLNETKQKLIDLEKSFVEDLAKLNKARVVAQSYLLDGEDGIENDTDWKSDVKEISDDEKNLRKIQTLLEFEAIDDAVTRYRDLMLDSKGKSFVTSFKSIRDVLMQWNEGLTEKVQKDLATKDQDAAWVTILKTVSVQKCILKSLNIIVGKSVLKDRYDFATNIIIETIGVSVYAEYKSLIVKKKEPKTYKKISKLIPNSALKKFYNLSTDNLDVIVLPPESKDIFSIGEFLVSQVFKHCTIQESLGEDGSKQSPAFTIQSHYANGVRTTKVIPHKNIFKLIEAGHEIRETGGARLFPMVIKPLPWITPTEGPYLHYKVPIMRTNGSAMQLRTLVDSDMSLIYRALNILGETPWVINRDLYNVILEAWANGGNIGDIPKRTDFEYPEISDDMLFDHEARKELYKKEQRIKSLNFNLHSLRCDTNYKLEVARKFLDHTLYFPHNIDFRGRSYPIPPHLNHLGSDFCRSLLKFEKSLPLGEKGLEWLKIHVANLYGVDKIPLNERLAFTERNMENIFDSVDSPLNGNKWWLKADNPWQTLAACMELTKAIRSGKPAEFLSNLPIHQDGTCNGLQHYAALGGDVWGAEKVNLLPSDCPQDVYSSVAQLVEQIVEEDAKNGDEIAQFFLGKVDRKLVKQTVMTSVYGVTYIGAREQIENAILEKFSDLDLDEDFIFKSSTYITKNTFASLNNMFVGARSIMKWMSDCATLIAKSGHCVTWNTPLGLPVVQPYKKGGKYNIRTLECDFIVVHNDDLLQVDSNRQRSAFPPNFIHSLDSTHMFLTAMTCYDQGITYSSVHDSYWTHASTVDRMNDILRNEFVELHKQPILERLLEWFQVRYPDIKFPKLPKKGELDINKVKESRYFFH
The following text describes a protein:
Function:
Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Miscellaneous:
MISCELLANEOUS: Present with 3250 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MSSPANLFPGLNDITDVLEEFPLATSRYLTLLHEIDAKCVHSMPNLNERIDKFLKKDFNKDHQTQVRLLNNINKIYEELMPSLEEKMHVSSIMLDNLDRLTSRLELAYEVAIKNTEIPRGLRLGVDNHPAMHLHHELMEKIESKSNSKSSQALKSESRREAMAANRRQGEHYSASTHQQDDSKNDANYGGSRHESQDHTGNNTNSRKRANAANTNNADPETKKRKRRVATTAVSPSTISTATAVNNGRIGTSTASRGVSSVGNSNNSRISRPKTNDYGEPLYCYCNQVAYGEMVGCDGADCELEWFHLPCIGLETLPKGKWYCDDCKKKL
The following text describes a protein:
Function:
Tegument protein that plays different roles during the time course of infection. Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection. Modulates the RNase activity of the virion host shutoff protein UL41 probably to ensure necessary levels of key cellular mRNAs and proteins. Plays a role in microtubule reorganization that occurs after viral infection by stabilizing microtubule network. Finally, may prevent nucleosomal deposition onto the viral genome by interacting with and inhibiting host SET. Plays a role in the inhibition of host innate immune system by targeting the CGAS enzymatic activity which is the principal cytosolic DNA sensor that detects invading viral DNA. Acts by mediating disruption of liquid-like droplets in which CGAS is activated, thereby preventing CGAS activity.
Subcellular Localization:
Virion tegument. Host cytoplasm. Host nucleus. Host Golgi apparatus. Note=One of the most abundant tegument protein (about 2000 copies per virion). Localizes in the cytoplasm at 8 hours postinfection and in the nucleus at 16 hours postinfection. During virion morphogenesis, this protein probably accumulates at the trans-Golgi where secondary envelopment occurs.
Sequence:
MTSRRSVKSGPREVPRDEYEDLYYTPSSGMASPDSPPDTSRRGALQTRSRQRGEVRFVQYDESDYALYGGSSSEDDEHPEVPRTRRPVSGAVLSGPGPARAPPPPAGSGGAGRTPTTAPRAPRTQRVATKAPAAPAAETTRGRKSAQPESAALPDAPASTAPTRSKTPAQGLARKLHFSTAPPNPDAPWTPRVAGFNKRVFCAAVGRLAAMHARMAAVQLWDMSRPRTDEDLNELLGITTIRVTVCEGKNLLQRANELVNPDVVQDVDAATATRGRSAASRPTERPRAPARSASRPRRPVE
The following text describes a protein:
Function:
Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAAAGAAATHLEVARGKRAALFFAAVAIVLGLPLWWKTTETYRASLPYSQISGLNALQLRLMVPVTVVFTRESVPLDDQEKLPFTVVHEREIPLKYKMKIKCRFQKAYRRALDHEEEALSSGSVQEAEAMLDEPQEQAEGSLTVYVISEHSSLLPQDMMSYIGPKRTAVVRGIMHREAFNIIGRRIVQVAQAMSLTEDVLAAALADHLPEDKWSAEKRRPLKSSLGYEITFSLLNPDPKSHDVYWDIEGAVRRYVQPFLNALGAAGNFSVDSQILYYAMLGVNPRFDSASSSYYLDMHSLPHVINPVESRLGSSAASLYPVLNFLLYVPELAHSPLYIQDKDGAPVATNAFHSPRWGGIMVYNVDSKTYNASVLPVRVEVDMVRVMEVFLAQLRLLFGIAQPQLPPKCLLSGPTSEGLMTWELDRLLWARSVENLATATTTLTSLAQLLGKISNIVIKDDVASEVYKAVAAVQKSAEELASGHLASAFVASQEAVTSSELAFFDPSLLHLLYFPDDQKFAIYIPLFLPMAVPILLSLVKIFLETRKSWRKPEKTD
The following text describes a protein:
Function:
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
Miscellaneous:
MISCELLANEOUS: In the RecBCD complex, RecB has a slow 3'-5' helicase, an exonuclease activity and loads RecA onto ssDNA, RecD has a fast 5'-3' helicase activity, while RecC stimulates the ATPase and processivity of the RecB helicase and contributes to recognition of the Chi site.
Sequence:
MNHPNLLTALNQAGALRTLDLAFAQSLQRLAPDTDPQVLAGAALASLAVTSGHAGLDPTRAAMLLDAREGPSPALPDPTDWQRTLAASRWVDQPNPQEPAAADCPLVLEHGLLYLRRYREYERRLALGLQRIAAHSPPPFAAATLAPLFEQLFPQASPLPQGEGARRAGEGTGLPEPSIYQDGTNPPEPSHHQDHQAQAAALALRRTLLLVTGGPGTGKTTTIARLLLLRIAQAHASNTPAPRIALAAPTGRAAERMAESLRAAVARAIANGIDPALADALPTGASTLHRLLGVIPDSPQFRHTADNPLPFDLIVVDEASMVDLPLMCKLVEAVADGTQLILLGDADQLPSVEAGDVLAAILQAAGPGDTLQPQDADALQPLLGSAPPGSTPASIQTGGHTISHTHTGGLAGHRVHLLRGYRQADNFALTPLADAIRTSDADTALALLRSGELAGVHFHEDGEDPLALGRDALLAHWRALADAHDPAAALRDAARLRLLTAVRAGPQGARGLNARIEQLLAESGSGARRLGSASPWFQGRLLLITENSYRHGLFNGDVGICLRSEASPFSERSDTNAPSERSDASTVTARSDAAASSGPSHSIGTANRADPVAERRAQGPLVAWFEGDGDSQVRGFHPAALPAHESAFAMTVHKAQGSEFDTVWLQLPTRDARVLSRELLYTGITRARRALHLAGSEAALRAALARHAARISGLAWRLGGEQMQPAPVEQTAEPPTVTPVQGSLF
The following text describes a protein:
Function:
Not known; does not seem to have protease activity.
Miscellaneous:
MISCELLANEOUS: Although strongly related to peptidase C2 proteins, it lack the essential Cys, His and Asn residues of the catalytic triad at positions 84, 242 and 267, respectively.
Subcellular Localization:
Cytoplasm.
Sequence:
MASKYERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVFLNESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAHGVFRFRLWWCGEWVEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQMPILSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKVKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEFWLSFCDFVEIFSTMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNHESFHINPQLLISVQDEQDLVIALNQHTAVEPKVIGFTMYTWDGEYMLSECLQKDFFKNHVSYLNSDYGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCLETQTMILLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEACLPNDYIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRDALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVIEVHLHDWIKSILSC
The following text describes a protein:
Function:
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
Sequence:
MPSSLPTMILKHLADFKPQAATRAWASIPNPNNLPLIATATSDKSVRVYSLSNFTLHSKLEGGHERSVRSAAWKPGVRKDGALTLATGGFDTMMTIATGSFDATMGVWRRKEEQKNTIEDGPLELEIGADGRPNKGPSLRRGGDDGSDEDEGDDWEFSIVLEGHDSEIKHVAYSPSGQWLASCSRDKTIWIWEEIGDEGEDEFETVAVLQDHTADVKCVCWRKDDGNGEVLASGSYDDTILLSKEDGEGDWETIAKLEGHDGTVWSLDWEPDVSIKSDSSEESSVPPTPRLLSSSADMTVRIWSKMPTPPPQNKPSYFNAGIPSTMRPGPVNETWECTATLPKVHDLPVYSINWSKYSGRIVSTGGDGRVAIYEERTKGRNTVGGTIEKEWVVLTVLEGAHGPYEVNHVTWCMRYDNGKKKPDEEMIITTGDDGLTKAWFIEEDIEESKVEA
The following text describes a protein:
Function:
Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2):heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. It also catalyzes the oxidation of F(420)H(2) with quinones such as 2,3-dimethyl-1,4-naphthoquinone, 2-methyl-1,4-naphthoquinone and tetramethyl-p-benzoquinone.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIGDTMSGIIDSYIPVAIFLAVGLIMPPMTMFMVKQLSPRSKAASKYTTYESGSVPTGTARIQFNVEYYLYAIAFVLFDIEVLFLYPWATVYKGHGITSIAVVEMFVFIFILLFGYVYLWKKEALTWVK
The following text describes a protein:
Function:
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTSPVKVLIHGASGRMGKALLRLAAEDDALHVVGAVVGRSPSQRVVDGVPYFAANELGGAPAFDVAIDFSLPQGFAPILALCVQRGKPLVSGTTGLDEAQRAGLLQAAGQIPLVWASNFSLGVAVLTELVERAAGSLPGWDCDIIEAHHVHKQDAPSGTALTLGEAATGSGAQPRFASVRAGDIVGEHSVQFTGLGERVELIHRATNRDIFARGALHAAKRLLGKPPGSYRVRDLVL
The following text describes a protein:
Function:
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Subcellular Localization:
Cytoplasm.
Domain:
Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex; The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.
Sequence:
MDGWSEVLRIPSSVFATDNYNNPTTIVNITSLQFDSVQNFIWCGDSRGYTRSFTGSFATNSLYGNLQLYPYTKFHTSDVNYNNPIKQILSHREGILSLSNNAISFNSRRGLSKLQVTSKTFNNNATTENKFNNLQAMTFNCNSFNDVVVGTDTSMMKFDLNKPNVLSSFDHQGGISLLNNLGKFLTIANSNGSLDIFDPVSNSTMKTFSAHNGFISNLDVRGNYIATCGYSIKPKRYYHNQPAEYIVDPLVNIYDTRIMRAIAPVPFPAGAASVKFHPKLPNIIIIASTSGQMQFVDIFDQTNVYLYQADLAIPTTTTTTINNKPRMSNLEISENGDFLVFNDNCDNMHLWSISPSSKDFVNFPQPVEQPDIIDSNFEIIDIDANVPLSIVGMPYYKELLLSNYPNDLRFVKETAKLPEPIDIELILENETRNNGTKKFFPYDKLKYGPGNVYKPYQSLKDNKENKEISIPKFISERSTTTTTTTKELKADNDGKFIDDSIFQYKFQGKLNKVPNCYSRLQIQYSKFGIKDFDFSYYNKTKECCGLENHTDNSYINSLLQLYRFQSSIYNQVVGSLSKEWLPNDITTIITTNNPEGSSILNELGYLFDMMFKAQSNNVKIYNLSQVLNHHPNAQKLLNNNELLNLNSQQVRDLVIEFNNFLLTTLHQDFQTQFQENFNLTELKYEIEIKGNGTSCPMYDKHQGSMFSLELITPPSNMLNKMSILINNNNNNNNPQYQPEPISSLDNIRRNLNILTYLEYSMNQYKTIPCQQHNHSYPHNLEIQTSIVHLPSVLTINVNLSNPEFKIINNFTQWLVPEFYAVKSKSISGKNGYSFKEIDHPTPNSATQESGKYKYKYELLGYVCEINHQSDIVSGAHNLVAFIKVNNNGGWYLFNDFLVMPIPEEEVFDLQPSWKKPIVIMYQQTNQPSFNYLTTTTTTTTTTTTFSNAGKYDDSILYRDHFAEGIRKGHQLEYELLTRKESPQPGSLVAIDAEFVMLKPEELEIHYDGYKKLIKPKQLSLARISVLRENGIPFIDDYIVHTSDIYDYLTNFSGIEPNDLNLTLSNRENLVTLQTAYRKLWLLLNLGVIFVGHGLYNDFRTINLQVPERQIRDTAVIYYKSDFKRQLSLKFLAYVMLKEKVQSGNHDSIEDANTALLLYKKYQNLYNKEDFESILNYIYSEGQQLRFKVPE