lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MSATSPSRRSSMASPSSRLKRKAAGNAIESSTGVQSAESASTSAFHLDYAPSSAAPSPLKRQITSSASRRNSHQSQALHMSDDFDPDQDAPYDEELDADADADAEYDQDYLDQDAPGEDEQDLLDAMHQNQNQSAAASPKSNTTMTPSRQSARPRRSNAPGVSYYATQPLLTFSDEEHEEEVTPSIRRRARRTQLPSTSDIDADPDDNANDESATVPTRLSSRGTRTNTPSKYKQTCAKPPRQPVHQDDRDKSAEPELSEEAKQLAKAEKESQDLQSRWTEEYFEIVEQLPLEIHRTFALMRELEGQMQSRMGTMIQNMTAYRDVRMHMQKLIDSEFQKQTQIQNTTQDNDTSRKGTKGGSEDEAEHLLGGSQQVSTNDQLPSLQGDASGVRVVTHDKLNETDLLDKDARRELLRSISLAANESVKAAEEKMGLAATAYNWIDRHIRRVDADISKLESSILLGLRTGTEESRGAREALGLPIDGTEAQARERDDEDEDEDAQGAVASGVSAEAESAALTKAAGAANRALAAEKEVTVGGRRSARTTPKMGAQAPRTPSPRGSERGAVQARSRSTSTSGVAVVAVTATRQKTSSPAPSVARTARKRKPKPLSPQKGGRRSIVTTTSTVISPTTQTPRASAIVGPDTSEMPFDPTEPTYCYCDQISFDEMVACDNDDCTIEWFHYACVGLAKQPENEWYCRFCAPPAWKGPGMRVPPNAKHKPPGFRKGIGIKP
The following text describes a protein:
Function:
Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAFGDDDILSIPFKYFVICIGGLPSSALLICVILSLLLHFDQATSTHCEVANWLPSISAAVSTYTPEKYIWRILIGLHIGPRLVVAIAFRNFLLGSPLRPLTGHKRLRFLCNLACFLNLLENFFLLALTSISSSEDHSLHAKCFGGFAICSIIYMLLSTWLFNETGRRTATNLGQRSHEYKILGAAIFVLCFFLGAYLYWRHNTYCEPGIYTLFALVEYSAVLSNIFFHCTLYYDFHGKNIVLTSSFGGGHYNLLPTQIDKDT
The following text describes a protein:
Function:
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
Miscellaneous:
MISCELLANEOUS: In the RecBCD complex, RecB has a slow 3'-5' helicase, an exonuclease activity and loads RecA onto ssDNA, RecD has a fast 5'-3' helicase activity, while RecC stimulates the ATPase and processivity of the RecB helicase and contributes to recognition of the Chi site.
Domain:
The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA; The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.
Sequence:
MNVSRTYKFKSSFIEASAGTGKTYTIMEIVIDLILEHKIPLTQILILTYTEKAAGELKERLRKKLISSGLTKEARELDQVTISTIHGFCNTILKEYPVETETHTNWILTDALERLNIALYKLQHEEWNSWVDPEKLEDFILSSKYRFKKENILISASKLLSGKKYKYSNETTTMTSETFLQKTALIIADMVLKEFKTSEWMSYDQMILKTRDSLENPRLRKALQSRYRVGILDEFQDTDGAQYEIFKRLFLESNDDRALYLIGDPKQSIYGFRGADIGIYLQAKEELKKHKAEEISLNVNYRSVPELIRAYNEIFGGKSGKQSFFPILEQSIPIQYEPVFAPKENIKVLLSDKQKQGPIQIVRFTGKDFWNTQDAKNAWGQFISEEILKLIHKEDPFTYQVAEGDLYYVEKKLKLREIAVLVKSKSEGKLAEQFLKLRGIPCSFYKQEGIYQSAESYQISNIFECLLDPNKPSSYRKLLLGDLFQIHPAHLPYFDEHSIDSYEKSILDRWKTLSMDRKFSELFRSIEEDSRIFLTEDATDIDWERKRTNYRQIFRRLLQFQIANQADLEEILEELKLLQKSFKNEEELPLFEKETEKDAVQILTLHASKGLEWPVVFLFNLSGDYIPEVYDYPFVDKDGKLSWKLSLWDNEEEKKISKEIYSNQSLNENKRLLYVGITRSKVRIYLPFYTPLNNWKTRDSAYYKILYPRLQSILENEIDTDLFHVVSWAPTPFDSTDPKRIDWNLDSEICFTPLLYEEPETSKTIRLNSYSSLRTSMNFSEEVSLSVLEEKTRIQSDDVENSETVIKDALPSSASIGSFLHSLLEELDFSIFKTTTSKELLKNEKIISRMDFHLDYFRILKREEGRPILEKETVQKRTVEILWNLLNANILDQKGALFRLVDLPKENRVSEMDFYLDLDTNPGNFLRGSIDLVFQIDDKFYLADYKSNLLEDYSTISLKRNVENLESRYDLQRDIYALVLYEYLKNLFGPKEALQKIGGVYYFFLRGMIYGESSGIYSDFFWSLERIESIRKTVLESTTFRWEKSN
The following text describes a protein:
Function:
Involved in the biosynthesis of capreomycidine, an unusual amino acid used by non-ribosomal peptide synthases (NRPS) to make the tuberactinomycin class of peptide antibiotic such as viomycin and capreomycin. Catalyzes the dehydration of the C3 hydroxyl of (3S)-hydroxy-(2S)-arginine and the intramolecular cyclization to yield (2S,3R)-capreomycidine.
Sequence:
MTGPLGAGPQALPAAPLEDWLRERYFQAKTDISSSGVHNYTFGELRALDPALLGTRELDQLMFRDGPSLGDERLRAAVAARVRPGPGHVVMTTHGSSEALYLAFAALVRPGDEVVVATPAYHSLSGLATAAGASLRPWPLRPENGFAPDLDDLRAVLSDRTRLVVVNFPHNPSGACVDPRGRTELLDLVANSQAVLLWDGAFTDLVHDHPPLAEPSQDLDRVLSFGTLSKAYGLPGLRVGWCVVPQDLVSELVRIRDYLTLSLSPLVERVAAVAVEHADALITPRLTEARHNRRRVLEWAAASEGAIDCPVPRGGVTAFPRFTAHTDVTDLCERLLARHGVLVVPGRVFGQADRMRIGFSCPRPELERGLAAISEELGTHARGRRRGTG
The following text describes a protein:
Function:
Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MIEINDVNKKYQQTTVLNEINERIPSGGITSIIGPNGAGKSTLLSIMSRLLAADSGNVLFNGLDVAKTSGDKLATILSVLRQENHFTSRLTVSDLVGFGRYPYSRGRLNKNDRQHIDAAMEFLNLMPLKDRYLDELSGGQRQRAYVAMVLCQDTSYILLDEPLNNLDMKHCVAMMKQLRRAADELHKTIILVIHDINFASAYSDHIIAMKNGEVIYRGAPAEIMQPSILEEIFDIKISIEKVQGQHIAVYYR
The following text describes a protein:
Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Sequence:
MVSFLRKKFRRISTMPLLTPSGKQFSLHKLVAMSTMLTPGHGVHLPSLNNTTAGDPPRQVYLSHEIQEYLRKLFDELRGPEPCLGREKFEKWLADVQGHTITLEKDTYKFEQFLESVYYSHSLEVMKRIPELDQSRPITNYYISSSHNTYLEGNQLLSRSSTEAYKTALTQNCRCIEIDVHNGEAAEKDDKSIFSNKTDHKRQPSGTGSTLSSRAAAAILTVEEKLESAKEKLEIAKEKLEGKHKVSKTNTGDKLKVLDEDEHGGRPASIRSSMIGEPLVLHGWTLTAPVGFRAVCKAIRETAFTTSPLPIIVSLEVHADHEQQEIMVDIMKEEWEDLLLDSPFETCNPEERVPRLEELLNKILVKVKKAPELKDASEHLNELTNGSTNGLSPTNTDTLEKKASSNTLVPVISTKDAESAHSGSEDDRASSKKKAKICETLGKLGIYTHSEHFVSFDVGAATKPSHIFSVGEKVILELHESNREQMFAHNRNYFMRAFPAGKRFDSSNLDPSVCWRKGIQMVALNWQTLDEGMMLNEGMFAGSQGWILKPPGYRSEDVTSESCAAIPYKTLDLKISIFAGQQIPFPQGETEKGFHPYVKCELHVESQEELDGQPIENGGKAKEGEHKLKTAYKSGSKPDYEGETLHFEGIRNVVEELSFVRLVHVTLLFFNIYTSEGYTIRKLDKV
The following text describes a protein:
Function:
Antimicrobial peptide. Active against some Gram-negative and a variety of Gram-positive bacterial strains. Active against fungus C.glabrata 090902 but not against C.albicans ATCC 10231. Shows hemolytic activity against human erythrocytes.
Subcellular Localization:
Secreted.
Sequence:
MFTMKKPLLFLFFLGTISLSFCEEERGADEDDEVEMTEEEKRGLRDKIKNVAIDVAKGAGTGVLKALLCQLDKSC
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Subcellular Localization:
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Domain:
Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
Sequence:
MQVSVESTSALERRMTVGVPAERIETEVNKRLQQTARRAKIPGFRPGKVPMSVIRQRYEASARQEAMGDLIQETFYEAVVEQKLNPAGSPSVEPKSFEKGKDLEYIATFEVFPEFTVSGLEDIKVERLQAEVSDADVDNMLDVLRKQNTRFEVVERAAQNDDQLNIDFVGKIDGEAFAGGSAKGTLLVLGSGRMIAGFEEGLVGAKAGEERVLNLTFPEDYQNLDLANKAAEFTVTVNSVAEPKLPELNEEFFALFGVKETGLDGFRAEVQKNMERELRQAIKSKVKNQVMEGLLQANPIEVPKALIGNEVNRLRVQAVQQFGGNIKPDQLPAELFEEQAKRRVVLGLIVAEVVKQHELKADEGRVREMIEEMASAYQEPEQVVAWYFKNEPQLNEVRSVVLEEQVVDTVLQKATVTDKQVSYEEAVKPAEAPQAA
The following text describes a protein:
Function:
Implicated in the regulation of ecdysone-triggered gene hierarchies. Probably plays a key role in mediating the regulation of the larval molt by 20-OH-ecdysone.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLSDGYHHHPVALHQHQHHHYQVPATPSVIKENHLVAATTTTATSAAATSSVPEGSSSPSAERQLQVPKVSAGPNPPTSPPVITYHAVHGGSSSSVYTSHPKILHSMKSISADVAASSKAEDALGHPHHHHPHHLHHHHHQLSVYGRGGPPHQQLQHHQHSSSVVVVVPKQESASSTTAGGGGGSPPTTPPVIMDNSVASSSSSSGNGGVNNTSTSGGSSSSCSPGPKGEPDLNIEFDGTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKARILAAMQQSTQNRGNQRALASELDDQPRLLASVLQAHIETCEFTREKVAAMRQRARDCPSYSMPTLACPLNPAPELQSEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDALFVRLICMFDTSINSIICLNGQVMRRDTIQNGANARFLVDSTFNFAERMNSMQLTDAEIGLFCAIVLITPDRPGLRNVELIERMYTKLKACLQSVISQNRPDKPEFMQELLRTMPDLRTLSTLHTEKLVVFRTEHKELLRQQMWSAEEDQGAVLDAKSPASWSCDGNQVEVEIAKSPMSSVSSTESTETSSSSSSSSSSSSEYHHLHHHHHQHGGISSAASAAAPLLAATLSGACPIIRHRASSGSSAEDDLIGGTAQHLAQNGLTITPVIRSVGSSSSSASSASSSSASSGAGASHLHHHHHHHHVSRYRKLDSPTDSGIESGNEKHDNPSPQQQQQQLHHQQHHHLLLHPKPASSSVSSGSSSCSSPRSSLEDPALEDSSSSSNGKAPSLARHASVDNMPVLKRVLQAPPLYDTNSLMDEAYKPHKKFRAMRHRESEAEAASSSTTTTSASAAPSPSATVLASSSSPRPASVPQPQQSVVAIAAPSPPQQPAQQPPQHHQSQLHMHLTRPQTTQSHQSSAGFLQSTSARSSPQPPQQQQQHHHAYSSLSSTHSVLAKSLMEEPRMTPEQMKRTDIIHNYIMRESAQEQQQNYIKQQQQQQQGGLLVCGASAANGVFQRASPHLTVSAVSPAPSSSSSSGSSPAAAAAPTGGCPFGGSSSSASAGRWQQVIPAVTASVITTTGGHRAQQTPSPGSLTPPDTSSSSSSSSLSVVSSPPSAASPSSSSSSATSIRYFQSPHSTMTSPAPPASPSSVVVVAPPHTPSPRLIELKVDIGSSATATTSLDPCHQQPLNLSKKSPSPAPTPVSVVQRSIVGGPSALSPVGAATTVVVATSSSSSNAATSSSSSNNPTIHKILLEA
The following text describes a protein:
Function:
Calmodulin-binding protein that acts as a guanine exchange factor for Rab10 and Rab11. Essential for maintenance of adult photoreceptor cells. Upon light stimulation, required for trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes via Rab11-dependent vesicular transport. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins in follicular epithelial (FE) cells. Functions by targeting Rab10 to the basal cytoplasm, where it restricts the secretion of BM proteins such as trol/Pcan and vkg/Coll IV to the basal surface. Appears to be involved in regulating the levels and distribution of the guanine nucleotide exchange factor strat, however the two proteins appear to have independent roles in regulating polarized BM protein secretion in the FE.
Subcellular Localization:
Cytoplasm, cell cortex. Early endosome. Recycling endosome. Cytoplasmic granule. Note=In follicle cells (FC), accumulates at the plasma membrane and in both early and recycling endosomes. In FCs, detected at the lateral and apical cell cortex during early stages of oogenesis. At later stages, mostly expressed at the lateral cortex but some expression is still detected at the apical surface. Colocalizes with Rab10 near the FC basal surface. In photoreceptor cells, colocalizes with Rab11 in punctate structures.
Sequence:
MEEKRIADYFVVAGMPENPQLLQENSFNDSGRLRAATTIEPITDIGVYFPLLGEEVPEGYEILSHTPTGLQANLNHGSVRTTDCYIYFRRGKDRPPLVDIGVLYDGHERIMSDAEIVAETPGGRVANVNNSSAKTFLTYRRARADMPCNELVVTELCVIVQSKGERAPHAFCLIYKTLNKGYVGSDVYLCYKKSMYRPKHISYKPEILLRYPTFDHTDFPLNLCPSVPLFCLPMGASLEAWPHVNGTEKRKPISPVFSTFVLTVSDGTYKVYGSALTFYEDYDESKLSAEQKELLGWDEEFGAQHSLHMIKAICLLSHHPFGDTFDKWLKYLHRMVLYDVNIPIPVERYITQLLDEVPFPAPSIHLQLSSESNDRILLTQPEDSPLPRSGAGFHILLQNLGTDNCLHVLLLALTEQKILIHSLRPATLTAVAEAIVSLLFPFKWQCPYIPLCPLGLAEVLHAPLPYLIGVDSRFFDLYEPPTDVTCIDLDTNNISLCESQRHLSPKLLPKRAARLLRQTLTELENAKPISYDSTNSLDRDIRKRKRELVLEQRIQEAFLLFMASILRGYRDFLVPISKAPSVGATDPSALFQLKAFLRSRDKSHQKFFELMMKTQMFIRFIEERSFVSDGDHGLSFFDECAEKVGNYDETPAQLHLVDWDTGQNSERTKYIFPPDSVTPAGSQPGGGGGGLAYNYENFTLQPELLQSTKKTALSKFLQLQLNASLSPGSPIARRTKHEIKLSQKMASRCQQHPEAWSKYLLATCYSLYFLILPSMVLDPRHAGKEPEILRAAYDVLVRASRLKITCDEFCYRIMMQLCGIHNLPVLAVRLHYLMKRSGVQANALTYGFYNRCVLESQWPQDSTTISQIRWNRIKNVVLGAAQFRKAGKQRAASKVNKSLSASQDQNLSTLETVDGQSRTSLASSSGDGGGHGLLDFAAFDRLRNKLGSIVRQTVTGGNNETMGDAVNNTGLLIPGELSAPNTPTYGGDTEILAKALQQQQPRKQIMSIGGGDDDDEDEDEDEYTAGSPSTPQKQLEAGADDLEYAGGGDYEADEEDEDEVDEHVAAQRARQRVQSPTKISPRTPVTQNDPLGALNEEESAASATPTQETQQEQQHSQSQIDSSIYSDKPILFRGQRSATFDESTQIGKSMHRSETMPVASSGVTNSLANIGSSLKFTFGRYSPARLSLKKDLKLPANIIENISSISPSLTGKKSNELIQGSLSSIKSAANSLTKKFDEIKGVISANSTPTKTNNGHHPHGLHHGHHHPHHHHHHHSQHGNAEQEEHDAAVHEEGKLRRVSSDLDPWGRLSESRKSSYNNLVPLGENSSTGALHMHAFPAVPDNLYSLTSENAADRDCDVLIQLTTCSQCHNCSVLVYDEEIMSGWTAEDSNLNTTCHACNKLTVPFLSVQIERQVEESEQSDPLQDGKEQIANGNSHKTSLTVPYLNPLVLRKELENILTQEGDIALIKPEFVDEHPIIYWNLLWLMERIESKTHLPELCLPVPSDKEHIDPLSKVKTVHIQCLWDNLSLHTEASGPPMYLLYRETQPTSPLIKALLTDQAQLNKNVIQQIISAIRCNDFATPLKRLANERHKLKSNGVERSHSFYRDILFLALTAIGRSNVDLATFHREYAAVFDKLTERECNMYYRNQDLPPSASTIFCRAYFRPLLLP
The following text describes a protein:
Function:
Plays a critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has replication fork regression activity, unwinds stalled or blocked replication forks to make a HJ that can be resolved. Has a DNA unwinding activity characteristic of a DNA helicase with 3'-5' polarity.
Sequence:
MTEAERQQVIALGRLLAAERRDGCADRVTTDGLVAYLNQWSAAAGSAARLPAVQRALGCLVGYDGMTLVERDQALAEAIEILRSLFRTAPTAPVETTVPPSPAVDPTANAGHVPVTKRNTSARQSRKRAANVDQRPLAELNLDAPLEQIAGIDWRLVGGFRRLGVRTIRDLLYHFPRRYDDVRNRRSISELQVGAEETVIGEVTDVRTIGAGPKLRVRVEVSDETGSIEAIFFNQRWIAQQIRVGQTIALSGKVTTFGGKRQFSSPRWERYTPDPDALLHTGRLVPIHPLTQGLHENQVRRFIKQVVDTMAPQVEDHLPPVRLQHARLLPLGEALAQIHFPTDHTSLAAARRRLGFDEFLFIQIGVLQRKRLWQQEMGYAFTIDSQVHAELQRLLPFQLTTAQQRAIEEIFSDLRRPSPMARLLQGDVGSGKTVVAAAALLQAVANGFQGALMAPTEILAEQHAKNLKQLLSRVRVPRKTTSATASSAYQQADWRSLLDPEEAAQLAEIISILGMSPEEDMGGHGVRVALLTGSLGTRERRRVLEGIARGEIDLVVGTHALITETVQFAQLGLVVVDEQHRFGVEQRLRLKNKGYNPHMLVMTATPIPRTLTMTIYGDLDVSVLDERPPGRQEIRTKRVGRAERAKVYRHIRKQVAEGRQVYVICPLVEESEKLDLPSAEEMYERLQHEVFPDLRVALLHGKLSAREKDDVMRAFRDHQYDILVATAVIEVGIDVPNATTIVIEGAERFGLAQLHQFRGRVGRGHHQSYCILISDSDNQQSKERLAALEQTTDGFKLAEIDLQLRGPGEFFGTRQSGTPDLKMAQQGDTRLLAEARALADAILADDPELKRPEHDLLRRKVNDFWAAATQSG
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MIKLLFTYICTYTYKLYALYHMDYACVCMYKYKGIVTLQVCLFYIKLRVFLSNFTFSSSILALKNPNNSLIKIMAILPENSSNLDLTISVPGFSSSPLSDEGSGGGRDQLRLDMNRLPSSEDGDDEEFSHDDGSAPPRKKLRLTREQSRLLEDSFRQNHTLNPKQKEVLAKHLMLRPRQIEVWFQNRRARSKLKQTEMECEYLKRWFGSLTEENHRLHREVEELRAMKVGPTTVNSASSLTMCPRCERVTPAASPSRAVVPVPAKKTFPPQERDR
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSLTLRCRGPSGQATVSVDAASPIADFLALLAEKTGVPAACIEILSGFPPKQIQVPSEGAVSALGLANGDTLTVRQGAAPALPPAAALPPVAPQSEPSSSGAGAATHSAAAGAGAGALGGFADMEDEDEMLARAIAASLESQQSGAGAGASGAGVSGAGPAATPRPAGAAPGAALAAPSSGAPRSVTNAPAGGPAPSSVPVPGGDGSCVVRRVVDSDNSCLFNAVGYVMEGSRSTAARLRRVVADAVRSDPFTFNEGFLGKAVEVYCDWIQQPDKWGGAIELFILAQHYKREIAAFDIRTKRCDIYGQDKGYPDRVLLIYDGLHYDALAVAAFAGAPEELDVTCFEPDTAGGRAITAAAEKLVEATNAARQFTDTANFTLRCGVCQIGIKGEKEAVEHAKATGHSNFAEY
The following text describes a protein:
Function:
Participates in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes. Protective against the mitochondrial apoptotic cascade.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MRILIQFTKRHPWLTNVTIYGSLFASADIVQQKLSKSPTEPIDFKQTAKVGLVGFCFHANFNFFWLRFIERTFPGSAPLNVIRKVACDQLMAAPITISAFYTGLSLLDGERDVFKNLKEKFWPTYKTGVMCWTVFQTINFSVIPPFVRTAYIGVCAFLWTTFLCYIRNRDINEVTTRLLHAVPNIRGKMAFPQDQDDNKPADK
The following text describes a protein:
Function:
May be involved in the biogenesis of the COX complex.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MTKLVSKIFKRLISQSQYMSSSTTSNLPAASQTSNLESQLLSSAPPPAKKKRGSALLWYLVGFTTYGLGETYKFLQTQVEHLDSRKQCLEMKPMKLNTTKDLDGLGFRRVVCKGIFDEQRSIYVGPKPRSMSKSSEIGFYVITPLLPIPNEPNSMKSPILVNRGWVPSDWKENSLESLGTGGLVAAAKESRKANKLLSSQQSLLSKFWYKLNNPMIVEDQVSRAMHVEVVGVVRKSETPGIYTLVNYPSSLAWFYLDVPKLALAMGFGEDTMYIESTYTDMDESRTYPVPRDVENLTRSKDIPLDYHLYTVLWHWSSLTCFIKASSILMRRLTKSDPIGVEPILIPISILVFICTKIYSLRNLFCKIDTIGVGCVTKLDTGKVK
The following text describes a protein:
Function:
Catalyzes the breakage of the C-P bond in alpha-D-ribose 1-methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose 1,2-cyclic phosphate 5-phosphate (PRcP).
Miscellaneous:
MISCELLANEOUS: The sequence shown is that of strain K12.
Sequence:
MANLSGYNFAYLDEQTKRMIRRAILKAVAIPGYQVPFGGREMPMPYGWGTGGIQLTASVIGESDVLKVIDQGADDTTNAVSIRNFFKRVTGVNTTERTDDATVIQTRHRIPETPLTEDQIIIFQVPIPEPLRFIEPRETETRTMHALEEYGVMQVKLYEDIARFGHIATTYAYPVKVNGRYVMDPSPIPKFDNPKMDMMPALQLFGAGREKRIYAVPPFTRVESLDFDDHPFTVQQWDEPCAICGSTHSYLDEVVLDDAGNRMFVCSDTDYCRQQSEAKNQ
The following text describes a protein:
Function:
Together with the minus end-directed microtubule motor KAR3, plays a role in microtubule organization. Recruits KAR3 to microtubules, and together they may stabilize the polymers. The KAR3-VIK1 heterodimer cross-links anti-parallel microtubules. Targets and/or maintains KAR3 at the spindle pole body during vegetative growth.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Nucleus. Cytoplasm, cytoskeleton.
Sequence:
MASQQNKHAFLSKNRIFHNPDNVSSSKSRNLMDITNTTNTMNGSRPSSMKSSLALPPVKDSFPSVSRSASLNINMSKIKDLKDRQDKIRFQRHTLRTQLIECEREIKTIKFRDLNKSRFELYKKKSKQAKYLKQVRDLTQNLNSKDGERADLIKKNKSALATLQAELDQNLILKRQESQELYNNKLIFWENELQIMENVEPDHEITEEISQLKKTLQELNINWANLQKQNLERQVNHESQLRKDFIAFKEAKLKSMENLTNKHRELLDQIATLQSESEKLHKEIMDIDRQAEYSEQNISEINENIKQLELANNPLISKSLQNSQDLEHLQNQMENLKEMASKQEKFYNDTYNTVEKELLRSRRLENSIIEQKGTMRCYAYVMEQNLPENLLFDYENGVITQGLSEHVYKFNRVIPHLKVSEDKFFTQEYSVYHDMCLNQKKNFNLISLSTTPHGSLRESLIKFLAEKDTIYQKQYVITLQFVFLSDDEFSQDMLLDYSHNDKDSIKLKFEKHSISLDSKLVIIENGLEDLPLNFSCDEHPNLPHSGMGIIKVQFFPRDSKSDGNNDPVPVDFYFIELNNLKSIEQFDKSIFKKESCETPIALVLKKLISDTKSFFLLNLNDSKNVNKLLTISEEVQTQLCKRKKKLT
The following text describes a protein:
Function:
May be involved in cell wall biosynthesis.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MTKDGAKGVSLPGNAILLGTLGTVVIFVCLFAMDVETVIGWAKYSSQKAVADISSIRNNQPEKSSSESASVRRDALVNITHDPTCLARTQHLLYRRDPERFQPLPEFDKAWDRYVAMHQSCTQGKNWTQVFLHERNMTVDCNYMIVMEGSGGLGNKLLSLTSAFAYALATDRIVLVESRKHFKDLLCDPFPGSSWYLPEGFPYDNVWGNATRMNVAISKNFTDVDNFVRLSLDHIQTWADGQFFCDHTHNGLAKVRWLAWTSNQYFITRLLMIPRVWERLNPLAKPGQIFTILSHKLLLPNNKLWAHVVRLYFAYLAGSSRRVGVQVRLHGRPNLAEFDPVVYDRILDCLQTNRALPKLREEEDVSDLMSFARNGYEGSTEISVLVTSLQLRYYDEMKDLYVNRPNVNGTVIRFHMVSHLDRQDGSMHQSETAFVEMWLLSFSDVLLISRYSTFGYIPQGIGGIIPSHLNTQTVPPGQENNASSCHPGISTQPCTHFPQKPRCDPGSTGNESHREWMRCHVRECVDHEGGLQLVQESEQPNESARLWGDVLQS
The following text describes a protein:
Function:
Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site.
Subcellular Localization:
Nucleus.
Sequence:
MSGRDLIGIAKTGSGKTLAFILPMFRHILDQPSMEDGDGAIAIIMAPTRELCMQIGKDIRKFSKSLGLRPVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIIDNVRPDRQTVMFSATFPRQMEALARRILKKPIEVIVGGRSVVCKEVEQHVVILNDDAKFFKLLELLGIYQEAGSIIVFVDKQENADILLRDLMKASYPCMSLHGGIDQFDRDSTIIDFKSGKVRLLIATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTFITPEQSRYAGDIIRAMDLSGTLIPAELQALWTEYKALQEAEGKTVHTGGGFSGKGFKFDEQEFNAAKESKKLQKAALGLADSDDEEDIEQDIDQQIEQIFAAKRTVKDTSAAATAAAAAAAAAAAAAAAVSGANPALASAAAQAAAAAAAANIAIAAASAPAAAGGAPSVAMGGALSSDKLELAKRLASKINSSKNLDTKGSVVTVEPMIKGPHVTGAAATLLTARTVAEQMAAKLNNKLNYQPKEDEEGLGPLVGGTTNPFTKYEEELEINDFPQQARWKVTSKEALAQISEYSEAGLTVRGTYVPQGKNPPDGERKLYLAIESCSELAVQKAKREITRLIKEELLKLSSAHHVFNKGRYKVV
The following text describes a protein:
Function:
Plays a critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has replication fork regression activity, unwinds stalled or blocked replication forks to make a HJ that can be resolved. Has a DNA unwinding activity characteristic of a DNA helicase with 3'-5' polarity.
Sequence:
MDPVPALQEPLKKVLGPATAKVMAEHLGLHTVGDLLHHYPRRYEERGQLTHLADLPMDEHVTVVAQVADARLHTFASSKAPRGKGQRLEVTITDGSGRLQLVFFGNGVHKPHKELLPGTRAMFAGKVSVFNRRLQLAHPAYELLRGGDDEGEAAESVESWAGALIPLYPATAKLESWKLAKAIQTVLPSAQEAVDPLPGSLREGRGLVSLPEALLKIHRPHTKADIEDARARLKWDEAFVLQVALARRRHAESQLPAVPRKPGADGLLTAFDDRLPFTLTDGQRKVSREIFDDLATDHPMHRLLQGEVGSGKTLVALRAMLAVVDSGGQAVMLAPTEVLAQQHHRSVVEMMGELAEGGMLGGAEHATKVVLLTGSMGAAARRHALLDLATGEAGIVIGTHALIEDKVQFHDLGLVVVDEQHRFGVEQRDALRGKGKQPPHLLVMTATPIPRTVAMTVFGDLETSVLDQLPAGRSPIASHVVPAADKPHFLARAWERVREEVSNGHQAYVVCPRIGDEDDDPGKGAKQSKQPPEGDADKRPPLAVLDVAEQLARGPLQGLGVEVLHGRMQPDDKDAVMRRFAAGETDVLVATTVIEVGVNVPNATAMVIMDADRFGVSQLHQLRGRVGRGSAPGLCLLVSEMPEASAARQRLNAVASTRDGFELSRIDLEQRREGDVLGQAQSGARTSLRVLAVIEDEEIIAEARQEAAAVVAADPELTGLPGLRTALEALLDEEREQYLEKG
The following text describes a protein:
Function:
Transcriptional regulator involved in pattern formation and cell determination in the embryonic CNS and larval imaginal disks. Also later in development to coordinate the expression of regulatory and structural genes required for photoreceptor cell fate in the ocelli. Has a dual role in the terminal differentiation of subtypes of photoreceptors by regulating rhodopsin (rh) expression: essential for establishing the expression of rh genes in the pale subset of ommatidia as well as repressing Rh6 in outer photoreceptors.
Subcellular Localization:
Nucleus.
Domain:
Contains multiple repeats consisting of single amino acids (e.g. Gly, Ser, His, and Asn) and pairs of amino acids (e.g. Gly-Val).
Sequence:
MAAGFLKSGDLGPHPHSYGGPHPHHSVPHGPLPPGMPMPSLGPFGLPHGLEAVGFSQGMWGVNTRKQRRERTTFTRAQLDVLEALFGKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQLQQQQQSNSLSSSKNASGGGSGNSCSSSSANSRSNSNNNGSSSNNNTQSSGGNNSNKSSQKQGNSQSSQQGGGSSGGNNSNNNSAAAAASAAAAVAAAQSIKTHHSSFLSAAAAAASGGTNQSANNNSNNNNQGNSTPNSSSSGGGGGSQAGGHLSAAAAAAALNVTAAHQNSSPLLPTPATSVSPVSIVCKKEHLSGGYGSSVGGGGGGGGASSGGLNLGVGVGVGVGVGVGVSQDLLRSPYDQLKDAGGDIGAGVHHHHSIYGSAAGSNPRLLQPGGNITPMDSSSSITTPSPPITPMSPQSAAAAAHAAQSAQSAHHSAAHSAAYMSNHDSYNFWHNQYQQYPNNYAQAPSYYSQMEYFSNQNQVNYNMGHSGYTASNFGLSPSPSFTGTVSAQAFSQNSLDYMSPQDKYANMV
The following text describes a protein:
Function:
Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.
Domain:
Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.
Sequence:
MYFKAFYDNFKEEYVYLKNENENLPAILTCEKTNSMENDTIIRRIPNSILKRMEDQNAEYTKKNNISDKLERLRELFINADKNTHEMLKCNVDEKIWTFFLSYHINKDMKITESSWLFNEYYFYRYLCCAYDFEKTNYDFFQYEKQDSINCNKVIIENICTCAKTLIELYDKNPQKKIFSVFFYYALWANQFDLSWNPTKNKSEQHNVQEKDIRKKTLREKQFCFDTDDIDKLYNSFYMENILCNDINDIYKDMTVQKHKRFDIVLDNMGVEFITDFCLLYFLTHYFEEITIHVKKFPLFVSDTMIKDIHYTLNVLCNDEKYPNTMFMANKWKELIQSQKWKIRDDIYWNIPLPYWVMSKNLLEELKKSSFVCFKGDANYRRCLGDLSYDFSTSHKDILNYFPFKVIALRCLKSPLGCGIDEKTVQELNQNNPDWSNYGEYAILQYNSPE
The following text describes a protein:
Function:
A cytochrome P450 monooxygenase involved in the biosynthesis of strychnos monoterpene indole alkaloids (MIAs) natural products, compounds with effects on glucose absorption. Catalyzes the conversion of geissoschizine to akuammicine.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MEFSFSSPLLYILYFLLFFIVRQLLKPKSNRKLPPGPRTLPIIGNLHQLRGSLPHRTLKKLSDKHGPLMHLKMGERSAIIVSDARMAKIVLHNHGLAVADRSVNTVASIMTYNSLGVTFAQYGDYLTKLRQIYTLELLSPKKVRSFYNCFEDELDVFVKSIRSQVGQPMVLYEKVSTYLYATICRTIFGSVCKEREKMIKIVKRTSLLSGTPLRMEDLFPSMRVFCRFSKTLNQLRGLLQEMDGILEDIIVEREKTTEILKEAKDDEDMLSVLLRHKWYNPSGARFRITNADIKAIIFELILAATLSVADVVEWAMVEILRHPAILKKVYDEGRGICKEKKRVTGYDVEKMEYMRLCVKESTRVHPAAPLLVPRECREDFEVDGYTVPKGAWVLTNCWAIQMDPEIWPEPEKFDPERYIRNPMDFYGSNFELIPFGTGRRGCPGILYGVTNAELLLAAMFYHFDWEIADGKKPEDIDLTENFGAGCIMKYPLTLVPHLANE