lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.
Sequence:
MVPQQLILKNFLSYQDVSLNFRGLHTACICGSNGAGKSSLLEAITWAIWGKCRAESEDDVLHNGTDQVRVDFEFISNNQTYRIIRSRQRGRSSVTEFQIKSGDHFRTLSAKGLRATQEKITNTLKLDYETFVNSAYLRQGRADEFMLRKPSERKQILADLLKLDQYEMLATRAKDISKEAKGKINILDERLQILEQDLNQRPDVVANQAKLVAEITEVQAQQQQTQWQLQQLQTSQNQRQQWQKQAGWQQRQCQELTTEIARLENQNEEINQQCQKLKLLLEQEAVIQVNFQRYQTLQSQETELAKAFQQYQNLQQQRQDLEQQLQRQENELARQTEQQLLRLEHLDKQLAELQPILAQQQDIEADLDKLKIAKQKLSQLDNLQHQVAPLLQRRSALQGDLARARAQCQAQLEQRQAIAKQLQIAIAAIPEQRRAFQALDEEIFQLKNKQVYLKRVEEKGQERGHFKERLQENQRLFEKQLRELEQKLTLLGIPGATCPLCEQGLDGHYHQQVIEKTEHQCQELRNQIWILKEQITLADQELAILRNEYKEIADGLTNLEQLLQHYGQMEAELEKSGENHEQLVELNEQIADLELSLTEGNFAESLQLELAALERELTNLAYDEQTHALARSTVDQLRKGEIRQAKLKEAQSKYRQLTGDRPGLEQKLLALRSQLQSLGTSSPLRQQWQQVSTAISELNYNNETHQQLLGELRRQQPWQLKHQELEQARQQLPILIQRGQEYQDLIGDRQRALEERQGELAQLEEQIRQYADHGEQIKLLEQELAQRRQQLDNLLAKKGGLEQLLIQIDTLQGEYEETKQQFDQAKKQFRIHQELGKAFGKDGIQVMIIENILPQLEAETNYILARLTGNQHHIQFVTQKEGKSSTKNKPKMINTLDILIADAQGTRPYETYSGGEAFRINFSIRLALAKLLAQRSGTALQLLIIDEGFGTQDADGCDRLVAAITAIASDFACILTVTHMPQFREAFQQRIEVNKTEFGSQLAIVS
The following text describes a protein:
Function:
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
Sequence:
MIKKVQHALILNELTKLRDKNTTTSQFRMALNQITSLLFFEATKQLPLATVEVETPFAKTKGYKLKNDIVLVPIMRAGLGMIDAIVRYSDKIRVGHLGIYRQTQTTSVISYYKKMPENISDSHVIILDPMLATGTTLLTAIKSIKEDKPIKISVIAIVAAPEGINKVEKMHPHVDIFLAAIDEKLNDNRYIIPGLGDAGDRLFGTK
The following text describes a protein:
Function:
Activates VirG, by phosphorylating it, in the presence of acetosyringone or hydroxysyringone.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNGRYSPTRQDFKTGAKPWSILALIVAAMIFAFMAVASWQDNATTQAILSQLRSINADSASLQRDVLRAHTGTVANYRPIISRLGALRKNLEDLKQLFRQSHIVSESNAAQLLRQLEVSLNSADAAVAAFGAQNVRLQDSLASFTRALSSLPGKASTDQTLEKPTELASMMLQFLRQPSPAISFEISLELERLQKQRGLDEAPVRILAREGPIILSLLPQVKDLVNMIQTSDTAEIAEMLQRECLEVYSLKNVEERSARIFLGSASVGLCLYIITLVYRLRKKTDWLARRLDYEELIKEIGVCFEGEAATTSSAQAALRIIQRFFDADTCALALVDHDRRWAVETFGAKHPKPVWDDSVLREIVSRTKADERATVFRIISSKKIVHLPLEIPGLSILLAHKSTDKLIAVCSLGYQSYRPRPCQGEIQLLELATACLCHYIDVRRKQTQCDVLARRLEHAQRLEAVGTLAGGIAHEFNNILGSILGHAELAQNSVSRTSVTRRYIDYIISSGDRAMLIIDQILTLSRKQERMIKPFSVSELVTEIAPLLRMALPPNIELSFRFDQMQSVIEGSPLELQQVLINICKNASQAMTANGQIDIIISQAFLPVKKILAHGVMPPGDYVLLSISDNGGGIPEAVLPHIFEPFFTTRARNGGTGLGLASVHGHISAFAGYIDVSSTVGHGTRFDIYLPPSSKEPVNPDSFFGRNKAPRGNGEIVALVEPDDLLREAYEDKIAALGYEPVGFRTFNEIRDWISKGNEADLVMVDQASLPEDQSPNSVDLVLKTASIIIGGNDLKMTLSREDVTRDLYLPKPISSRTMAHAILTKIKT
The following text describes a protein:
Function:
Component of the ribosome.
Sequence:
GRTVRWLKYIRIQRQKAGLLKRLKIPPPVAALDSAEAKKARLQARAEARAAGKKEEVTKRPNMVRFGIHNLVLIAHDVDPLEVVIFLPALCRRKFKIPYAIVKGKAALGTVVRRKVTVPEWSDLVKLGVT
The following text describes a protein:
Function:
Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.
Sequence:
MAGVSGGSVQDLCEEATCSVCLDYFRDPVTLAECGHNFCRACLGRWWGDSEKEAFCPQCRLTLQSRDVIPNRPLANFVEITKKLSLQGPRGAGAMGGVCGEHQEPFKFFCKEHQRPICVVCDRAKEHREHTVIPLQEAAQEYQDQICNCLKNLKEDKEKFLASKAAIEKESQDLLNETEVEREKVMSAFRELHHFLEDQEKRLLVQMEEIEKEIIRKRKEHLARFSREISFLGSLIQEMEEKLHQEASESLQDIGRILKKTEKRGTFCSVVFIPSAMKLKISNMRNMNPFLEGALKKFEDLFLERKKMEEVAGNMAEFRSESTGIRAQPQFPRRWEDVLLSGPPPKKVNVTLDRDTAFPRLVLSEDLKCVRWDQKYQNLPENPGRFNLSSFVLGREEFSAGRYFWDVSVGSEERWAVGVARKSVRRKGPVLISPGSGICAVEKSEGAWDGFTHMTGSRSRVDCISILIKARLEKKRKGCGILPPWKETVFQIRDPGLGNREECG
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Sequence:
MSDKCGNCDCADKSQCVKKGTSYGVVIVDAEKSHFEMAEEVGYEENDGKCKCTTGCSCAGCNCGK
The following text describes a protein:
Function:
DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.
Subcellular Localization:
Cytoplasm.
Sequence:
MCSWRCAAARSHASANRCTPKERLGRQENRSAHCPGTIRSIRMEWSRWERQEFRCKRSFQRLGSSCEQFSPPMQNRRWEIERLPWRFSPVGKPFHFRDNVRAMRYVELHCRSNFSFLDGASHPDELVQRAAELGYEGLAITDRESIAGVVRGFSPAQELGLQYIVGTEVHPTDAPPMVLWPTDRAAYGRMCRMLSTGRMRCEKGRCELSFEDIAEHAQGILAGVIATDESRSIEDQHAHVNDSRQFLRGPFRDVFDDRGYLLASFHRGVDDAAKATWLRNLSLATDVPLLACGDVRYHSAERMALHDCVVAISQGKSVEQIQSDRLVNSQHHLRSLEEIAELYRDVPDAVARTIEVAQRCTFTLDQLKYEYPVELAPEGMTPIEHLKRLTWEGARGRWPNGVPEKVIETLRHEVTLIEDLQYEAYFLTVWDLVRFARSQEILCQGRGSAANSVVCYCLGITSVDPTHTDLLFERFISRERGEAPDIDVDFEHQRREEVLQYLYEKYGRDRAGMTAVVTCYRAKSAIREVGKALAISPDIIDAVAKLAGSYSRNPELPERCRDAGLDPDTPLGRRFLYLTETLIGFPRHLSQHVGGMVMTAGSLCELCVTENAAMPGRSVIQWNKDDLDDIGILKVDILALGMLSAIRRCFELVKDHHNRELSLSTIPPDDTPTYDMICAADTMGVFQIESRAQMSMLPRLKPRCYYDLVIEVAIVRPGPIQGNMVHPFLAARENPAAAKYPNDAIRKVLEKTLGVPIFQEQAMKLAVVAAGFTPGEADQLRRAMAAWRRPGVIDRFRTKLLEGMKANGLNGEFAENVFRQIRGFGEYGFPESHAASFALLVYASCYLKRHYPTAFCAALLDSQPMGFYAPAQLIRDAQQHGVQVLPVDINDSNIRSKLIPDLNRPHPKLRLGLQMVRGLPSAVAQKIIVARDANGPFANLHDLTTRAKLSRSNIATLADADALASIAQDRRAAVWQSLAQDDSGDSMPLLADLEPDCSVPEELVPMSPAEEVKNDYATTGLSLKAHPVSFWRDDLNALRCKRASDLPKLRDGVHVRVAGLVLMRQRPGTAKGITFVTMEDETGSMNLVLFAQVWKRFFKIARGSDAWIVDGKLENKKGVIHVIVGRVEDLSEKASGLKVPRRDFR
The following text describes a protein:
Function:
Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.
Subcellular Localization:
Nucleus.
Sequence:
MSRRKQSNPRQIKRSLRDMEAGEEAKGMDISPMEQEATAPEAPAIEEPPSPPREDVSLPTVSAPPESPDDPEDVEGQELEMRPQDEKKEEKEEESAMASPWSGPEELELALQDGQRCVRARLSLTEGLSWGPFYGSIQTRALSPEREEPGPALTLMVDESCWLRMLPQALTEEEANSEIYRKDDALWCRVTKAVPSGGLLHVLLVAEPHGTPKHPVQEPEEAGSSGPVHTDIQLLPQQAGMASILATAVINKDVFPCKDCGIWYRSERNLQAHLLYYCASRQRASSPVSATEEKPKETYPNERICPFPQCRKSCPSASSLEIHMRSHSGERPFVCLICLSAFTTKANCERHLKVHTDTLSGVCHNCGFISTTRDILYSHLVTNHMVCQPGSKGEIYSPGAGHPAAKLPSDSLTGFQQHSLRHSPLVPADKAPTPSSGLDSKALAEVTNGETRVPPQNGGSSESPAAPRTIKVEAAEEPEAARASGPGEPGPQAPSRTPSPHSPNPVRVKAELSSPTPGSSPGPGELTMAGTLFLPQYVFGPDAGTTTVPAAPQASEILAKMSELVHNRLQQGAGSSGVAGTPTGLFPGTKGATCFECEITFNNINNFYVHKRLYCSGRRAPEDPPAVRRPKAATGSARAPAGVAAEPDPPRSSPGPGPREEEASGATTPEAETAGRGSEGSQSPGSSVDDAEDDPSRTLCEACNIRFSRHETYTVHKRYYCASRHDPPPRRPPVPTPAPGPAAPALTAPPVRTRRRRKLYELPAAGAPPPAAGPAPVPVVSSPTAELPSSPRPASASAGPAPTPSPGPVPDGPIDLSKRPRRQTPDTPTALPALADYHECTACRVSFHSLEAYLAHKKYSCPAAPLRTTALCPYCPPNGRVRGDLVEHLRQAHGLQVAKPAASPGAEPRTAAERAPRDSPDGRAPRSPSPAPENTPSDQADQGARTSCKGPPAPAPAPGGGGGHRYCRLCNIRFSSLSTFIAHKKYYCSSHAAEHVK
The following text describes a protein:
Function:
Participates in the assembly of the infectious particles by decorating the outer surface of the capsid shell and thus forming a layer between the capsid and the tegument. Complexes composed of the capsid protein VP5 and UL48A assemble together in the host cytoplasm and are translocated to the nucleus, where they accumulate and participate in capsid assembly; Participates in the assembly of the infectious particles by decorating the outer surface of the capsid shell and thus forming a layer between the capsid and the tegument. Complexes composed of the major capsid protein and small capsomere-interacting protein/SCP assemble together in the host cytoplasm and are translocated to the nucleus, where they accumulate and participate in capsid assembly.
Subcellular Localization:
Virion. Host nucleus.
Sequence:
MSNTAPGPTVANKRDEKHRHVVNVVLELPTEISEATHPVLATMLSKYTRMSSLFNDKCAFKLDLLRMIAVSRTRR
The following text describes a protein:
Function:
Transcriptional regulator.
Subcellular Localization:
Nucleus.
Sequence:
MEADGEGVVPVPSHSHSVSSPPHDDDHPDFSPVGSPESHFIDDLSQPSDQHHAQVTATLLTDDLRNKIVKQVEYYFSDENLPTDKFLLKYVTRDKEGFVPVKVIASFRKVKKLTKDTAIIAAALKESSLLVVSSDGRKVKRLHPLPLSEIIDPKVCTVLVENLPEDHSVDNLRRIFGQAGNVKHITVRDPHTERDSRKCTTAEKLLSGKLHALVEYNTVEAAEKAVAILNDEQDWRFGLRVKLLKKTNKPGQNKKGWRDPDSDRNMNIQASGQAVNEEYHSSEHRVLQNKPGQSKKGRSDPDSDRNTTIQASDLAVNEEHHSNEHHVDSPDEEEGDHRSKETVGEHAQKEKNEHRVQTRNRGRGRRNKRGTNGHGHGTTSYNHAVEPSKPPPGPRMPDGTRGFAMGRGRPVSSSPS
The following text describes a protein:
Function:
Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.
Subcellular Localization:
Nucleus.
Sequence:
MPAHTPIPDIPGELLTDPTLQYFLAERVSNLCGIGGGKFPGSQPVSFSSSSLELLENEDFWVCEKSDGVRVLIFIVVNQSTEQQEVWLIDRKQRFFKVQGLYFAHWENRSAFLGETLLDGELVIDIDPISGAQTLMYYAFDCMVLHGENIMEKPLLKRYARLRDWVVRPFEKALSANPDMRRTIPFMVVAKREELSYHLRFVMEEHIPKLKHGHDGLIFTCVHTPYVAGTDENILKWKPPSENSIDFKVELRFPPLPDSDEPDYSAKPEFLLNTWLGGDRYEFFDFMAMTDEEWQRFKESEEQLDERIVEVCWDSQIQAWKMLRMRDDKPHGNHKSIVDKILVSINDGVEIEELYARADTIKAAWKERGKQRSQQQPPQTQRPPPPAYGQDLHTPGHGYAHTGYNPDYSHPPPQQGVMSGLRR
The following text describes a protein:
Function:
Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (By similarity).
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Prevacuolar compartment membrane; Multi-pass membrane protein. Note=Cycles between the Golgi apparatus and the prevacuolar compartment.
Sequence:
MKYLKGLLLPALLALAPSATAAKDAPSIETTTFSNELVNLQYFDDSTVALVQELGSGKIYRSPDAGKAWKELKDLKKGLGIIKNPYDNKVALVLGEEQHWITYDQGETWQDFKTEYSPSPNGPVSWHSQDNKKILIHEIEDCLFTPCLGLTYYTTDGFKTKPKTLVEGRRMCQWAKGSERFLEGQEKHDDRILCILRGKYSDRSKDFRLMISDDYFKTAEEPVMSSGRTVQGMANMAAVKGYLVAAVKADHSSELSLYVTQDTENWHHAQFGNGKIEEDAYTILESTNYSIQVDVMSSKYVSIGSLYTSNSDGLYFTKNVDNTNRNPDGFVDFEKIANIQGVVLVNIVDNAKAVQERGAHKKLKSRISFDDGRTFEELKVKGSDKELHLHSSPGIVMGVGNTGDELGKYTDGDLYVSDDAGLTWELALDEAHKYEFGDQGSVLVAVFDEGDTDKVMYSLKHGRKDTWKSIDLGYKIRARELTTLSDSTSLRFLLYGSKKKDGGGREHVLIQLDFNDLHERKCEDKDFDPKWSDPTPTFESCECDEFRDFECDFGFKPEGEGKDKKCVPEKLTLPKDACKNGDSTYMGSSGWRKISGNQCKGGSKKDEKTERKCDEADLPPPKSDKITSEITRFKGSNFLEQYYLERSTQNDDDETDHDETVVMLTDERTAWITHDHGKQWKKAVDDEVVRIYPHQYDNNYVYFLTASKKVHYSEDRGLRNSIHSFEAPVMPNQEMLQILQFHPKQKGWLIWMGGKNCEKVNSKECHTAAYVSQKNGKDESWEPLVSYVKKCAFVWREAGRDVKEERVFCEQHANEETGAPLQLISSDDWFKKQDVKFKSVVEIALMSEFIIVATKEKDDTLRLDASLDANTFAEARFPPKFFDIHQTAYTVLDSSTHAIFLHVTVNPRVDQEYGSIIKSNSNGTSYVLSLNAVNRNTEGYVDFEKMQGLEGVAIANVVVNVNEVNDGAKKKKQTRITHNDGADWREKDAEGKAYECAGKGEEKCALHVHGYTERADPREMYSSPTAVGLMLAVGNVGEELGTFGEADTYMTTDAGLTWKEIKKGSYAWEFGDQGSVIVIVRRGEDTDHVYYTLDSGEKWNLYQFSERKIRVDAITTVPSDTSLNFLLWGKDGKELVAVNLDFSGLPQFQRKCDLDEKDPEKGDFDLWIPQHPLQPDDKQCLFGHVAEYHRKKRDAECRNGQRIDHMHNIQRNCTCTRRDYECAYNYERQPGGECKLIEGLDLEDPTAVCSKGAKEFWDVSPYRKIPLSTCEGGNEFDHMGDVHPCPGFEEEFEKKHGISGFGLFMAIVLPFAAAGGIGYYVWRNWDGKFGRIRLGENGGAFDSDSRWVQWPIAAISGLVAVVAAIPMLVGSLYRMVTGRMGGGYGGRTYTSRSSFARGRGDYAVVDPDEGELLGDDSDEEV
The following text describes a protein:
Function:
Involved in the early part of the secretory pathway.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein.
Sequence:
MSALFNFHSFLTVVLLVICTCTYIKMQFPAILERKTGFRGFFWKAARIGERLSPWVAFGCFAMGISIIIF
The following text describes a protein:
Function:
Has a dual specificity toward Ser/Thr and Tyr-containing proteins.
Sequence:
MGISMILDNFLYLGAAKDTKDEKEMEKLKITHIFSCAGTVHSPEKYIIANEKFEDDETVDISEQIEKAYWFIERVRMKKGARVFIHCMAGKSRSASIVLSYLLKRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKLTNKQTLSKEIKEWRSLQSKALKTKIDVQTCHFIQPSLDSTKKANEQYLLHIQSISFTFFEIHLNQDKIIQLYQQQCQLLHSNNIDIKYFTSILQEELSNSTKKAFDFLLIHYYLDWQDIINNLLNYTNLKLNLN
The following text describes a protein:
Function:
Putative chromatin regulator.
Sequence:
MTSPESLSSRHIRQGRTYTTTDKVISRSSSYSSNSSMSKDYGDHTPLSVSSAASETLPSPQYMPIRTFNTMPTAGPTPLHLFQNDRGIFNHHSSSGSSKTASTNKRGIAAAVALATAATIPFPLKKQNQDDNSKVSVTHNESSKENKITPSMRAEDNKPKNGCICGSSDSKDELFIQCNKCKTWQHKLCYAFKKSDPIKRDFVCKRCDSDTKVQVNQVKPMIFPRKMGDERLFQFSSIVTTSASNTNQHQQSVNNIEEQPKKRQLHYTAPTTENSNSIRKKLRQEKLVVSSHFLKPLLNEVSSSNDTEFKAITISEYKDKYVKMFIDNHYDDDWVVCSNWESSRSADIEVRKSSNERDFGVFAADSCVKGELIQEYLGKIDFQKNYQTDPNNDYRLMGTTKPKVLFHPHWPLYIDSRETGGLTRYIRRSCEPNVELVTVRPLDEKPRGDNDCRVKFVLRAIRDIRKGEEISVEWQWDLRNPIWEIINASKDLDSLPDPDKFWLMGSIKTILTNCDCACGYLGHNCPITKIKNFSEEFMRNTKESLSNKSYFNTIMHNCKP
The following text describes a protein:
Function:
Flagellar protein involved in flagellum axoneme organization and function.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme. Note=Closely associated to the axoneme along the paraflagellar rod.
Sequence:
MAAPAQAVVKEKPPIHVYPQAKIGTKIFTHHGIHSMRYNGVCALTGSTVLMASGRFVMFVDVHKGTIESMQGPENGGVGAVAVHPSRQYYVVCERKPSDPAIRAYSWPSRTEVGEFVKGATKGFSACAFNKDGSMMATVGMYPDFFLTVWDWESRGMVLRSKCHNTDVYTVLFSPFDSGLLVSGGAGHIKFWTMANTFTGLKLQGLLGKFGRLEISNVSGFVVLSDGKVISGSESGLIILWEGDLIRCCFAREVDREDDDGTAATFMARSYDYTPCHEGAINVVELMEGGRVLMTAGDDGYFRFWRVSELEVAEGEGAPPLYVPECLGEILVHAGAFIRSVTYCKDVDEWVVLDSAGVLWRVPYVHPDDILNNAVTKPKEQAVPALEFNGGSITSAALSPIDHTVVTGGEDGTIRLVDYVTPRELYKMCLPQPNVVIGLRFFQKDPEKKKFLACCKSGAVLLVKRGSTAFTLLGQWRPHNDGLALFAVDAAEHRLCTIAHGTVFFFTILDDFSSLEPIGFCKIPLPGATCVAWDDASSCCLIGFECGKLLAIRAPTRDMVDQSVSYEFTCNYALVGIRQRKKVEKKQANVSAGEREGFVEEEEEEEYLGPWPVRLICPMADGDFAIGAGGVELLYKYGLHVRYEGQKELPPLPPTGIEPPDYVEEPLMNLCYRDYTPEASSMSYSGRYLVVICEGSQMLLRQLDEMGRVRLEPILVASAHDRLDGPIAAACTSFDDKMLVSVGSDGLVVAQLLDGCIAPQPPSPVAQLQPLRAEEIVEPQLAPFSITEQKDLDDRRRAEDEKRRELNLFLDKLKDVHQKYARLLRENQSLALTHRLSKEEITIHPQIYRELQEEMRQRVEESRKPTALELARENIRTRKMRNRFVDNLAHDRFLVRSFSKEFSVASFRTPYVDGSIKLFQQQIDELLGSERCSSLACDGDRGIVSVASGEASQQSPRNLSLSTAAGVVRWLNSEERKRNEGEQQKMNAAHREAEILTTTMRQYLNKMDERREERHWRKKGYEMLLAHKPDPAVEEASLNEELRRETRRRGECILRTDPSYHSAPSAVIKLQQLIRLEEIIFNMRNNFSNELLKLRDEKERLCGTLNVSLQRIRAINEKLKDKSFHADDVKLTPEEMPGKRFEISRDGLVAFMKQRQEEKLREQTAKKAQRGFGADLATGEPATNTDTSGADTPATRRSEGEDSRKVTISANRDSFGTAAARTRSVRTGTLAASKGGRPFSGGGFAAGAARERMNHELRVKHENIKLTEMEEEELQIERNRLLAERQRLHTQVQAMMDEFDVRLWSMYEERSRVDANLCLAHTHSLLLFREYNILLVFRQKDFELQSSYDEARNSRDRCLREMEELQRLVQDQTASIEKLQEANKVFRREVEIFISNSFPAEHVPYITKVFLRQIKRRKHHSDMSGNDDDITSDDDDDDDMGEDEAWEEICPPNCSEERWCEVIEKREVRLDYVDAITEERRQLEATEQRIEEHKALADKNNAAVSTCLKAIEDFQGEKRKQLNMLETLVAMRCGQVRCLDEEGRCPDTFRRNDLVVVSDKVITGLHDRIRALAEEKHDRRGKLKSMVAEQQALQRERSEKQALHTQWEEKIYEAMLLKFGQIVNLEVLESSCGSREVEQLKERLRLEELSWEKELRKRDKKIAVLREKLHESLEYNTSLLQTIGDQESDRQSVERSLAQSTQKVVSKMYDSINVATEEDRSNLRLLIAAQQEEIDALRTEVALLRTKGGHVYAAAMAAGR
The following text describes a protein:
Function:
Catalyzes the stereospecific NAD(P)H-dependent reduction of 2-ketocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids. Can use both NADPH or NADH as reductant, displaying a marked preference for NADPH over NADH. Shows a broad substrate specificity, although it displays a marked preference for the 2-ketocarboxylic acids having an unbranched chain of 4-5 carbon atoms.
Sequence:
MHIERLAVDESVGRAMPPQRFIEALSDLGVPVEFAGEDEQFGPGDAVASFGHRDAFLDADWVHCIRAGYDEFPVGVYEEAGTYLTNSTGIHGTTVGETVAGYMLTFARRLHAYRDAQHDHAWDLPRYEEPFTLAGERVCVVGLGTLGRGVVDRAAALGMEVVGVRRSGDPVDNVSTVYTPDRLHEAIADARFVVLATPLTDETEGMVAAPEFETMREDASLVNVARGPVVVESDLVAALDSGDIAGAALDVFSEEPLPEDSPLWDFEDVLITPHVSAATSKYHEDVAALIRENIEKIATGDELTNRVV
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MARNPTDDVSQVVLLLDVNPFFWGAEAASGGRSNGSGGLAFDQYFQHALMFVNGILLLNHTNRIVIIATGSSTCAFLYDSTATDGINGSSVTSKANKKTQVSRTELITKSMQEFVSKEEEASKESSQIQYSNISGSLSMALCYIQRVLRGPLPHPQARILCLQGSPDAPYQYISVMNSIFSAQRNGVVIDACVVGSQHSAFLQQATHITGGIYMKPPQPDGLFEYLMMVFTTDLFSRQFLQLPRPVGVDFRASCFCHKKTIDMGFVCSVCLSIFCKHHQTCSTCGATFSRSNSTTVTGMKRKAPGS
The following text describes a protein:
Function:
E1-like enzyme which specifically catalyzes the first step in ufmylation. Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP (By similarity). Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (By similarity). Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding (By similarity). Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism (By similarity). Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes.
Subcellular Localization:
Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Golgi apparatus. Note=Localizes mainly in the cytoplasm, while it localizes to the nucleus in presence of SUMO2. Interaction with GABARAPL2 promotes localization to the endoplasmic reticulum membrane.
Domain:
The UFC1-binding sequence (UFC) motif mediates interaction with UFC1; The linker region is required to activate the active site of UFC1: it region moves next to active site of UFC1 to reduce the amount of water molecules in the vicinity of UFC1's active site and thereby elevate the nucleophilic activity of UFC1 active site; The UFM1-interacting sequence (UIS) motif mediates interaction with both UFM1 and LC3/GABARAP proteins (GABARAP, GABARAPL1 and GABARAPL2).
Sequence:
MADSVERLRQRVEELEQELARERTRRSGGDGHCGRTRIQEMSDEVLDSNPYSRLMALKRMGIVSDYKKIRTYAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPYQAGLSKVHAAEHTLRNINPDVLFEVHNYNITTVEHFEHFMNRISNGGLEEGQPVDLVLSCVDNFEARMAINTACNELGQTWMESGVSENAVSGHIQLMIPGESACFACAPPLVVASNIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKFLLKFGTVSFYLGYNAMQDFFPTMFMKPNPQCDDKNCRKQQEEYKKRAAALPTQEAEPQEEAEVVHEDNEWGIELVSEVSEEELKNSSGPVPTLPEGITVAYTVPKKTEDSASEVTVEDSGESLEDLMARMKNM
The following text describes a protein:
Function:
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Required during the endosperm development in embryos.
Domain:
The F-box is necessary for the interaction with ASK proteins.
Sequence:
MKTELEEEEEEEWRSVHEVLLIVLPYLHSLFELLSMIRVSRSLRDAIRDETALWTKLVIEPPLSSRLTDDILSEFSSKSAGKLKTLILRQCLMVTNKGLRRVVDANPLITKIIVPGCSGLTPEGIMECVESLSKNNHKLETLHINGVNGFTKQHLSALYTYLSSEGTIDLEVCPKCDEVRMIPSCSRESCNQKQRKCRGCWLCIPRCAECAVCLVGSDTESQEAACGNDDVLCLECWLVLPKCRFCNKPYCTNHSSRRHEIAITDAASRPSFECEACYYRAGTNPYEVDYQI
The following text describes a protein:
Function:
Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover.
Subcellular Localization:
Nucleus.
Sequence:
MKIAVEGCAHGELERIYDTIEGIEKVGGTKIDLLLCCGDFQSTRNLEDLQTMAVPKKYLDMCSFYKYYSGELVAPVLTIFIGGNHEASNYLQELPYGGWVAPNIYYLGYAGVVNVNGVRIAGISGIFKGHDFLRGHHEFPPYTDSTCRSVYHVRQLEVFRLKQISGRVDIFLSHDWPTGIYEYGNKAQLLRKKPFFAADMESGKLGSQPLEELLKAVQPAYWFAAHLHCKFAALVPHNHSQKLGDAESSSSSSSSEDEDEEREKVKKAAPVPPPSKSVPVTKFLALDKCLPRRAFLQVVEVPSDPIEGTPRLEYDAEWLAILHSTNHLISVKENYYYLPGKKAGEFTERSNFTPTEEELEAVTAKFQKLQVPENFERTVPAFDPAEQSDYKHMFVDQPKVQLNPQSNTFCATLGIDDPLCLVLLANGLDLPAVGATECKDRETKSSKLQAVEEDVAEPLVTPTKRKLNLSLPAPTTAAADTTDENVIDLPEEEAEEAIIATETPHVEEPASVPASPNVKKLKRRNQNIYQAQED
The following text describes a protein:
Function:
Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity).
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Domain:
The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.
Sequence:
MTSSNLPYAADAESPLKPAELQVLRAQYEKEGDYVGVQTKFNYAWGLIKSNFRADQQEGVRLLSEIFRAHPERRRECLFYLALGNYKLGNYGEARRYNDLLIDKEPGNLQAASLRTLIDDRVSREGMVGIAIVGGLALAAGVVGGLLFRGQRR
The following text describes a protein:
Function:
Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MAAAVAAPLAARGEEAAATTSVPGSPGLPGSRSAERALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPVELCGLSSLRDLNVRRNQLSTLPEELGDLPLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLSTEAGQRGSALGDLAPSRPPSFSPCPAEDLFPGHRYDGGLDSGFHSVDSGSKRWSGNEVRASCPWEIGGVSPGRGPLNWGPPNCRVPGRGWSCPLPSLCPASQGGAGSAKTLSLVPHRTPQAPSPHVQRGHLPSQPLPLQSTDEFSELSFRISELAREPRGPRERREDGSADGDPEQIDFIDSHVPGEDEERGTVEEQRPPELSPGAGDRERAPSSRREEPAGEERRRPDTLQLWQERERRQQQQSGAWGPPRKDSLLKSGLRSAVGGATAMSTQATHNGPPKSSASQAGATVGQGAPAPAPASQEPLPIAGPATAPAPRPLGSIQRPNSFLFRSSSQSGSGPSSPDSVLRPRRSPQIPDEKDLMTQLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVPSPAVPKLSALKARKNVESFLEACRKMGVPEESLCQPHHILEEEGAPGRGLPYIAAVVHALLDRP
The following text describes a protein:
Function:
ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
Subcellular Localization:
Nucleus.
Domain:
The DBINO region is involved in binding to DNA.
Sequence:
MADHHDSRRRYSHTRHHSASKSPVALMDRIVERSPPLHPQPSSRMSLSALVNDSPSPPRRITPPPAAYAERHPHPSAYYPSSTTDPGYMGAMDDRRYSYPPPRTSYVQPSTHPSPTASDYRYRSPVLPQHPPTHHSPSSYSASLYGQPKEDPAIAYARMREEMRTAEEARREAEALEYRRKRDMEFAARRPGSELMDDPRRIPHSSFPRSQMYGPSADQSRVMPSRNGKDYISEPPSPSELYPTDEDTERLPIDRYRRDIDVPPLPRQLPPPPSEIGRMADRARSPSAPIAPPLLKVVRKRTKVIRPNDFLVGNEDVWEDGLIRYQSKREDEVRAIAQWAASCQVRNGVGEPSLPQTQDESIKVRKINGDIATPTNKKKRKSRKLNLDDELLGLASSPPGSPNAAAEAEKSESKHHIYGMNGPIDPANPPSPSTIVYPSGLTRAEVIAKCEAGDVEGLTEDDVKAVQDEMWMREKAAQAAENGGVLPTNKDGTVRRKPGPAKGWRKIRGIDKKKETTPGKAQSTTAGSVAGSVADEEAEADIAALLDDSIAKKGKKVKRRKLEEPGAESPRFADAEDEYNEHRPSDSVLLDEIEDEHSRAGSVGESNALDTLPAASAPPKKKNSKTKEPGVGKGRWTRPTKPEKELVKKAEALASRTSKASLAGPSDDTFGVGPGPAEEVQEEIKHEYAPNTHDPRGVSENEAKIRHELVEDLQKQAWSNIVRDVPRIYRVFQGYDQSMKQIAQRRAQACVRNAFGQRNQKTMQRQSGKVNKEGAAKAKRIVKELAAFWRKNEKDEVIARKKAEREALERAKAEEEARETKRQSRKLNFLLTQTELYSHFIGKKIKTKEAEAAEGMDVEEEEKRGMEEIAIGEDGEPLPDLDYDEDDEENLRKHAARGAQAAIQAARDKARAFDDSIVGRGAPLPGDDTMDGDELNFQNPSLGENSVTITQPKMLMAQLKEYQLKGLTWLGNLYEQGINGILADEMGLGKTIQSISLLAYLAEHHNLWGPFLVIAPASTLHNWQQELARFVPRLKALPYWGSPKDRETLRKIWSRKNQTFSEDSPFHILITSYQLAVQDEKYLQGMKWQYMILDEAQAIKSSSSARWKSLLSLHCRNRLLLTGTPIQNSMHELWALLHFIMPQLFDSHEEFAEWFSKDIESSSGGVTGNLKPEQLKRLHMILKPFMLRRVKKHVQKELGDKIEIDLLVDLSQRQREIYKALRQRVSITDLLATAENNTDNGNPKNMRSLVNLVMQFRKVCNHPDLFERADVVSPFVFGEFSQSGNLAREGDGMYLPDSARNAIEVQIPRILWTDGGKLDIPGEQSLAGSDTKILQNLLNIWTPEWINERTKCADAEFGFVKLVGSSPGETSRSAKSPVLVQLLEGAEKERRWTEEGRFVDDSEFAASVKKGFRVPSVIPVLTQPGQVSLREISRRVWDESYLSRDDARCIGDYAIAPIVKPIASNRSFLNAQDRILNQPLAHSTLYGLAPSELHDPLAAEQFSRIAPSVPLTGLIPSSASSQTPVSPLHIPPTKRLIVDSAKLARLDSLLRELKAGGHRVLLYFQMTKMMDLIEEYLIFRQYKYLRLDGSSPIAERRDMVTSWQTNPDIFVFCLSTRAGGLGINLTAADTVIFYDHDWNPSSDAQAMDRAHRVGQTKQVTVYRLVARGTIEERILQMARGKKDIQDVVVGTKSVSDVAKPSEIVSLFMDDEELAESVAKRKQAEAHGYIAPTIIPNGRRSQFGDGLVLDDGEGDDGFFNAAAAARANAEEEEGLGAEEESKGKGKAKAAAAVTFPVPGEKRSHKKGMGKKAQAAAAAAALERVIAGNEEPLAASKPPAKKKVKIALGPDGLPL