lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of the MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF). Positively regulates canonical T cell receptor (TCR) signaling by preventing early PTPN6/SHP1-mediated inactivation of LCK, ensuring sustained TCR signaling that is required for optimal activation and differentiation of T cells. Phosphorylates PTPN6/SHP1 on 'Thr-394', leading to its polyubiquitination and subsequent proteasomal degradation. Required for cell surface expression of metalloprotease ADAM10 on type 1 transitional B cells which is necessary for their NOTCH-mediated development into marginal zone B cells (By similarity). Also required for the NOTCH-mediated terminal differentiation of splenic conventional type 2 dendritic cells (By similarity). Positively regulates osteoblast differentiation by acting as an upstream activator of the JNK pathway. Promotes JNK signaling in hepatocytes and positively regulates hepatocyte lipid storage by inhibiting beta-oxidation and triacylglycerol secretion while enhancing lipid synthesis. Restricts age-associated inflammation by negatively regulating differentiation of macrophages and their production of pro-inflammatory cytokines (By similarity). Plays a role in negatively regulating the abundance of regulatory T cells in white adipose tissue (By similarity).
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein. Membrane raft. Lipid droplet. Note=Located primarily outside cell membrane rafts and remains outside upon canonical TCR ligation. A small pool is detectable in cell membrane rafts in resting conditions but relocates outside the rafts upon TCR signaling. Localizes to lipid droplets in hepatocytes.
Sequence:
MRKGVLKDPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKNLLERQEREIETFDMESLRMGFGNLVTLDFPKEDYR
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and some mRNAs. Mainly catalyzes the methylation of uridine at position 54 (m5U54) in cytosolic tRNAs. Also able to mediate the formation of 5-methyl-uridine in some mRNAs.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
IGAGWSEVPEHMEDCGQDVSAVGSSAASVCQDEKEDPGPAAGPGTQPGLYSYIRDDLFTSEIFKLELQNVPRHASFSDVRRFLGRFGLQSHKIKLFGQPPCAFVTFRSAAERDKALRVLHGVLWKGRPLSVRLARPKADPMARKRRQEGDNEPTATQIADVVTPLWTVPYTEQLEQKRLECERVLQKLAKEIGNTNHALLPWLLLQRQQHNKACCPLEGVKPSPQQTEYRNKCEFLVGVGVDGEDNTVGCRLGKYKGGTCAVAPPFDTVHIPQATKQLVKAFQEFIRSTPYSAYDPETYTGHWKQLTVRTSRRGQAMAIAHFHPQKLSSEEVAGLKASLVCHFMEGPGKASGVTSLYFVEEGQRKTPSQEGLPLEHMAGDQCIQEDLLGLTFRISPHAFFQVNTPAAEVLYTVIQEWAQLDGGSTVLDVCCGTGTIGLALAPKVKKVIGIELCQEAVEDARMNALTNELSNVEFHCGRAEDLVPGLVSKLSSQQLVAVLDPPRAGLHSKVILAMRKAENIKRLLYVSCNPRAAMGNFVDLCRAPSNRVKGTPFHPVKAVAVDLFPQTPHCEMLILFERMQQHPNGIGALEHQDLQTPRNLPDLTAQETETSLSP
The following text describes a protein:
Function:
Excisionase and integrase are necessary for the excision of prophage from the host genome by site-specific recombination at the att site.
Sequence:
MPPRASIQETADYLGVSTKTVRNYIADGRLKAVRLGPRLIRVERESVEELMRPIGK
The following text describes a protein:
Function:
Activates hsk1 kinase and is essential for G1/S transition. Has a role in S-phase checkpoint control induced by replication fork blocks after nucleotide deprivation and DNA damage.
Subcellular Localization:
Nucleus.
Sequence:
MNLGRCPLAPRSANIVLPKHDAVSKQKEYRIEEKTNEAQREEIITWKDNREDEGEVKTDFEVVNNENIITTTPKHQTVITPKSYRKSVKRIKHDAPQNEDIPVMKGLAPINADTESKAESMAAGKVLGSKNSSQKARLQEWKRQYKKAFPHFRFYLDGCDPSVAHRVKKQIQQLGGHVETFFSGNVTHVATVRAIQDVSVKYAKQDVITKARQLNMKIWSMEKLCNRVLKTLMENDQCTTNAPTKQGNDLSYLLYVEKVQGTNERDLSVPRQDFVHFRGPYLYVHDIANIYKPILLREWQKPLPDRDVPWPTFRATSIGRCPFVPETKYRLSTSKSLVAKNDQQLLQRQSQEPSLILRANSMKASLPDISNTGISGMNTNTTYNTNINNTPQTAISGITQDTSPSIRTNCHHCLDDGMQASGIVQSNLTSAAMSNNSAIRSGSAASVPVVTINGRDIAELKKRIIQQKSGMIGKDYSYKAMLHNTSQRKIRVDAKPGYCENCREKFDNFESHIRSSRHRRFAENNDNFKDLDELFALVQRPLRPD
The following text describes a protein:
Function:
Dephosphorylates a number of phosphatidylinositols. Controls the cellular levels and subcellular distribution of phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has a role in sperm activation and motility. Influences the localization of the transient receptor potential polycystin (TRPP) complex proteins lov-1 and pkd-2.
Subcellular Localization:
Cytoplasm. Note=Observed in reticular structures.
Sequence:
MDWKITIFTYNLAMKASDSEAVHNMLNGMIDDHTHLVAIGLQEVAHSETIGGAVLTWATTIASWMNTNGRMVLLAKTFQATNQVLIFGRKQLIGQIKRIDYRFQRNTMGGLTGHKGSIGVRLQLASPYSIVFVDSHFIHGPENYGKRVEQYHTNRNCSFPEDKSVRAAFWFGDFNFRVEEDVNTVIRKIKNGTHLELLDTREQLKRALVERDAFIGFHEQPVTFEPTYRVTVGTTEQDGKRVPSWTDRILYKGDGITGLSYTNNKKAVASDHLPVVAMFRVTAPAAPKPQWEVIFEHLPTWYTSIPLVGRFQVNELYYKENGSYRDWIGVFPSSINDCTTATNWIYAATCFEQVIEGSKFLACEFNNIPAGNYRLGYFSCHLHCLVGLSKVFQIVEQP
The following text describes a protein:
Function:
May be involved in spermatogenesis.
Subcellular Localization:
Membrane; Lipid-anchor.
Sequence:
MGQQISDQTQVVIGKLPEKVAKHVSLVRESGSLTYEEFLGRVAELNDVTAKLASGQDKHLLFEVQPGSDSSAFWKVVVRVVCTKINKSSGIVEASRIMNLYQFIQLYKDITDQAAGVLAQSPTSGGTAENLSSGSSCQASLWMGRVKQLTDEEECCICMDGRADLILPCAHSFCQKCIDKWSDRHRNCPICRLQMTGANDSWVVSDVPTGDDMANYILNMADEAGQPLRP
The following text describes a protein:
Function:
Pore-forming subunit of gustatory voltage-gated ion channels required for sensory perception of sweet, bitter and umami tastes. With CALHM3 forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to membrane depolarization and low extracellular Ca(2+) concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of small ions including Ca(2+), Na(+), K(+) and Cl(-), as well as larger ions such as ATP(4-). Mediates Ca(2+) influx and downstream activation of the ERK1 and ERK2 cascade in neurons (By similarity). Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum (By similarity). May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Localizes to the basolateral membrane of epithelial cells including taste cells. Colocalizes with HSPA5 at the endoplasmic reticulum (By similarity).
Domain:
A phospholipid-binding pocket is formed between conserved regions of S3 and S4 helices of one subunit and S2 of the adjacent subunit. It may regulate channel assembly and gating.
Sequence:
MDKFRMIFQFLQSNQESFMNGICGIMALASAQMYSAFDFNCPCLPGYNVVYSLGILLTPPLVLFLLGLVMNNNISMLAEEWKRPAGRRAKDPAVLRYMFCSMAQRALIAPVVWVAVTLLDGKCFLCAFCTAVPVATLGNGSLVPGLPAPELARLLARVPCPEIYDGNWLLAREVAVRYLRCISQALGWSFVLLTTLLAFVVRSVRPCFTQVAFLKSKYWSHYIDIERKLFDETCTEHAKAFAKVCIQQFFEAMNHDLELGHTHGVLATATATATATEAVQSPSDRTEEEREKLRGITDQGTMNRLLTSWHKCKPPLRLGQEAPLMSNGWAGGEPRPPRKEVATYFSKV
The following text describes a protein:
Function:
In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response which coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the synthesis and degradation of ppGpp. The second messengers ppGpp and c-di-GMP together control biofilm formation in response to translational stress; ppGpp represses biofilm formation while c-di-GMP induces it. ppGpp activates transcription of CsrA-antagonistic small RNAs CsrB and CsrC, which down-regulate CsrA's action on translation during the stringent response.
Subcellular Localization:
Cytoplasm. Note=Is associated with pre-50S ribosomal subunits in a salt-dependent manner.
Sequence:
MYLFESLNQLIQTYLPEDQIKRLRQAYLVARDAHEGQTRSSGEPYITHPVAVACILAEMKLDYETLMAALLHDVIEDTPATYQDMEQLFGKSVAELVEGVSKLDKLKFRDKKEAQAENFRKMIMAMVQDIRVILIKLADRTHNMRTLGSLRPDKRRRIARETLEIYSPLAHRLGIHHIKTELEELGFEALYPNRYRVIKEVVKAARGNRKEMIQKILSEIEGRLQEAGIPCRVSGREKHLYSIYCKMVLKEQRFHSIMDIYAFRVIVNDSDTCYRVLGQMHSLYKPRPGRVKDYIAIPKANGYQSLHTSMIGPHGVPVEVQIRTEDMDQMAEMGVAAHWAYKEHGETSTTAQIRAQRWMQSLLELQQSAGSSFEFIESVKSDLFPDEIYVFTPEGRIVELPAGATPVDFAYAVHTDIGHACVGARVDRQPYPLSQPLTSGQTVEIITAPGARPNAAWLNFVVSSKARAKIRQLLKNLKRDDSVSLGRRLLNHALGGSRKLNEIPQENIQRELDRMKLATLDDLLAEIGLGNAMSVVVAKNLQHGDASIPPATQSHGHLPIKGADGVLITFAKCCRPIPGDPIIAHVSPGKGLVIHHESCRNIRGYQKEPEKFMAVEWDKETAQEFITEIKVEMFNHQGALANLTAAINTTTSNIQSLNTEEKDGRVYSAFIRLTARDRVHLANIMRKIRVMPDVIKVTRNRN
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in lichenan transport.
Subcellular Localization:
Cytoplasm.
Domain:
The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.
Sequence:
MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNHIDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS
The following text describes a protein:
Function:
Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein.
Sequence:
MSSLLAVMLVTQADQSSPSLAFAWPPRPQPTPRLDRPVYKQEQSRICGSDPSLYSGKKHAHGTHSADDRDHHGNRFVRAFQESDLWDGHYGESSSDETSSRAFKQPTSRRVLSSSSAGLPIPSRHEPSDFDDEDENPLFPGLLYDSHHSDSVRLSAKKSTKPSSSLPRGRSSYLGFGPDEWADMLTPRIHGSQHLSFNTPKGMVSGRKLELVIDALAIIGHPVLVNQKPTTSHTNPERSMERGRTRTRSGEKDVTSSPPDSPKKSSSSQSPFLNPTLPNQTSAPLPSSSSSSDPTISTNDGLVLSTLDLNDPPATLPNSSSSPCKPPLPAPISQLTRMMTPSITPLDTSSASSTKTRVFLHPRSSTRSSSSPSPVTLPARFNIRDRYNPIPYSPMCGFLTTAPTVTVDETQQANVIPPARSTQLVPLQSFTLALIIDTPPASHLSQHLEVYYRDVVLKLTAALKHLERESSYLTREVQLIMRKLSERRSSYSSRSASQKKQPEIEDCMEFVEQSSDLTRALARIFEDLKTLGSTSITLDHQLDLDLLLHRELLDSNSVPENWLLANSVKTPSPETGDQDRFAHLESWKSLLLLEDPQVLIEQTAPGSLLRDFIAIIKPALTLSEYKFLLDTDSNTIAEMTDHLLYWRKAKLTDMITLRNSYQLTCPAQTEPSAISPDRLPISELQQEFSATFPNLPHLVMILSSISQRSRQPFSSILPHLAPNLEKSESMAVLVWLLKRDLLLRERTHVRIKIDRQTKMNVALWEQEQKQQKGSEDYNEEIDEQSSLSPGSQTTRNRAHPSNPQTTPQVSTSLPTDSRYQSLSGSASKQMSSDVNRPESVTMQSVPQEGMLSERPSTTRNLSSVSDGQSRNSRLIQSVQPSSLSSITSSDEFGREDRRRLRQQSVQSDFSTLSESHPREIGSDGTAPTGLILLPHKVDLLADSIIGHPGQATAIEQKWLDEICADKTDAQIRAFNSLSLFPSLLLILSYLILLIFL
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MVHCCVLRVLLMLSCTPAWPAAVFIISEQQQEKLFRPESRGSHLRVRRGWIWSQIFVEEEDSTPRNIGQLKSDYDSGDFTIKYILSGEGAGEIFIIDEYTGEISSLQPLDREVKPYYTLQAQAINRRSKQPVEPESEFIIKVQDINDNAPEFINEPYVSSIPEMCPTGTTVIQVTATDADDPMFGNNAKLIYSILQGEPYFSVEPTTGIIVTSWSQLDREAKEIYLVVVQVKDMLGLSGGFSATTTVTISLTDVNDNGPTFQHNLYTFAVSESAPVGSTVGRIMAEDGDVGVNARMNYSLEDLEESSTFTIHTDPETQEGIIILAQPLDYENKRRFVIAVEAINENTDTRFLSMDQFSDRTTLKITVTNVDEPPVFSGTPYIWKVLENAQTSTQVGTVYARDTDITNTAIRYDLSETPDTQQMFRIDPDNGTVYVTNLLDRETAAWYNLTVFAREILDNQLSSSVSVLITVLDINDNPPALAHDYQPFVCEDAQPGELIELISATDADDPVDGQHFYFSMIPDKHINPNFTIRDNQDNTASVLARRSSFRRQEQTHYHLPVVIRDSGTPVLSSTSTLSIRVCVCQPNDHCPSDGAQTHTLPLDISMQILLGLAVCCITLAVALVLIYKTLFSSRALELMLENSLHFNWAVLSTLVLAVRKCKALQHEKAAPGEPKAEEFSQKTLSFSVPEPPSVPLRRLGRPSAACIRMSLRHSLLLGPEHQQFQQFMAERLAEADADLDADPHDCLHTYADEGAGSSAGSLSSLESLTFDPCGTLSWDAGPHRLRLSAWPAPTDQTSF
The following text describes a protein:
Function:
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Sequence:
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPDNGFAMRYDLIEKNEKHVEAIARAAKSADDIYLATDPDREGEAISWHIAEILKERGLLKDKTMQRVVFTEITPRAIKEAMLKPRAIAADLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIDAHCRHPSQPFNARLIKLDGQKFEQFTVTDGDTAEAARLRIQQAAQGVLHVTDVASKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVALGDEGSVGLISYMRTDSVNLSQDALAEIRDVIARDFGTASLPDQPNAYTTKSKNAQEAHEAVRPTSALRTPAQVARFLSDDERRLYELIWRRAVACQMIPATLNTVSVDLSAGSEHVFRASGTTVVVAGFLAVYEEGKDTKSSEDEDEGRKLPLMKAGDNIPLDRIVTDQHFTQPPPRFTEAALVKALEEYGIGRPSTYASIIQTLQFRKYVEMEGRSFRPTDVGRAVSKFLSGHFTRYVDYDFTANLEDDLDAVSRGEAEWIPLMEKFWGPFKELVEDKKDSLDKTDAGSVRVLGADPVSGKEVSARIGRFGPMVQIGTVEDEDKPTFASLRPGQSIYSISIEDALELFKMPRALGQDKDQDVSVGIGRFGPFARRGSVYASLKKEDDPYTIDLARAVFLIEEKEEIARNRVIKEFDGSDIQVLNGRFGPYISDGKLNGKIPKDREPASLTFEEVQQLLADTGKPVRKGFGAKKATLKKNAVKDSAKEAKDAAKKTAAVKKVATKTAAKKAPAKKAAKKATKRVVKKAVSKAAG
The following text describes a protein:
Function:
Catalyzes the cleavage of L-arabino-gamma-lactone to L-arabonate. Is involved in a degradation pathway of L-arabinose that allows A.brasilense to grow on L-arabinose as a sole carbon source. Can also use D-galactono-1,4-lactone as substrate in vitro; however, the enzyme is probably not involved in the metabolism of D-galactose in vivo.
Sequence:
MQQIHPAGQATLLADTRNTLGEGATWCDRTRALYWVDIEGAQLWRCRADGSDLTPWPMPERLACFALTDDPDVLLVGLATHLAFFDLRSGAFTRIVEVEPELPTRLNDGRCDGSGAFVFGMKDEGAEPPRAVGGFYRLNADLTLERLALPPAAIANSIGFSPDGSKMYFCDSLVREIFVCDYRPGGEVANVRPFARLTDPDGDPDGSIVDRDGGLWNAQWGGRRVVRYGPDGVETDRVAVPTAQPSCTALDGEGRLYVTSARVGLSDDALADDPHAGGVFVAQTRHAGMATARFAGTPRG
The following text describes a protein:
Function:
Inner nuclear membrane protein. May have a role in maintaining the structural integrity of the nuclear lamina. During pupal development, plays essential and redundant functions with the other LEM domain proteins; MAN1 and Ote. Also has a redundant but important role with Ote in larval development.
Subcellular Localization:
Nucleus inner membrane; Single-pass membrane protein. Cytoplasm. Nucleus, nucleoplasm. Note=Detected in the nucleus envelope and cytoplasm. In the cytoplasm, it appears to localize to discrete foci; [Isoform A]: Nucleus, nucleoplasm. Cytoplasm. Note=Predominantly expressed in the nucleoplasm with very low expression levels in the cytoplasm; [Isoform B]: Nucleus inner membrane; Single-pass membrane protein. Endoplasmic reticulum. Note=Appears to be predominantly expressed in the nucleus envelope but expression is not uniform. Outside of the nucleus it is located to discrete foci which may be the endoplasmic reticulum.
Sequence:
MSDLSYLDTLGNKELLAKCLEHGLPGVPVTDSTRSVIIRRLKAKITGVPLNKSKSASKKAIPRRETVHGSQVTTPTSEPVRRTPGKSAGRTSSNNNKISEQSRRTIAYGLDNTSISGRSVQTTTTVSDMSSQSEDDDSYMVDSPVPNYSKDQQPRRYVSLAKSGVLTTSYTREVDQPLYEQEDIPRSYTYERPHVPAATLHALPTYEPRIEPSTYRPTDLGFSRPLLTQTNLNSTSYEESSTYNPKLSPISPRNTFSGSARPFGGPAPAPAPIRQRQSVPVSGSNLARGRLLQPTTAVNTLYPQLNEFYDQPNDAGEPMETESESEVEEVPINSHFQKNRFSPLARKPLVRHHDQVSPMAQFRALAVSLDQKYNLKFYLILVVSVMLATMVYVVLTPNA
The following text describes a protein:
Function:
Possesses low quercetin 3-O-glucosyltransferase and 7-O-glucosyltransferase activities in vitro.
Sequence:
MEELGVKRRIVLVPVPAQGHVTPIMQLGKALYSKGFSITVVLTQYNRVSSSKDFSDFHFLTIPGSLTESDLKNLGPFKFLFKLNQICEASFKQCIGQLLQEQGNDIACVVYDEYMYFSQAAVKEFQLPSVLFSTTSATAFVCRSVLSRVNAESFLLDMKDPKVSDKEFPGLHPLRYKDLPTSAFGPLESILKVYSETVNIRTASAVIINSTSCLESSSLAWLQKQLQVPVYPIGPLHIAASAPSSLLEEDRSCLEWLNKQKIGSVIYISLGSLALMETKDMLEMAWGLRNSNQPFLWVIRPGSIPGSEWTESLPEEFSRLVSERGYIVKWAPQIEVLRHPAVGGFWSHCGWNSTLESIGEGVPMICRPFTGDQKVNARYLERVWRIGVQLEGELDKGTVERAVERLIMDEEGAEMRKRVINLKEKLQASVKSRGSSFSSLDNFVNSLKMMNFM
The following text describes a protein:
Function:
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
Sequence:
MVMTANKQTDIHISKYLRNFLPNPSSISDTDEICVVSIIGKTPLNYLTCGTLADAVSGRNVFQRETIDDNDQKLEHGLLFYYNNEQKVVYINQASLYDTKELAYLCQKFNSDLSTWEHFQKWKRNEHKQLLSLLFIFSISHIILITHPSHKFDLSYLRLFRGLNAIRLHNQSVLTHHLCKIAKAANLSSQWRQRGRCCTPRLLFIFHLDININRRFQDGNRSKNRDVGQKDQDATSLFFNIGLATTLFQHFYVTQHDKVDDNDVLEKNFDEENSDLKNFLKYHINQTKAGNLPTSKTWFTAASYLQKVLIEDASGVDSIRYPISSSWLDIDKKFSESTCRKAISVALDCYEKNLPEQYNYAFHQKQLATSINTLSQLALGPSFPSYVQQLEKDCEKIWKNGRQSCEILSLTGKQCIYPKEIKQRKFRQSKNLPQKRAHSSNYWYISACNCGETIAKRPDPFDIKVANCTFYQMLEKKCCSIFPHISFPVNVDSNSHEEQSIDDHAMEIEEISAATSSKNNADSSNGVADDPTLDGLDTTTAIGQNSEFSSSPSPAPAANLVSMKIEPDNCKKDGESSNSIIMFTINTPAGYLPRFSSWSLCRLGDNNIYKASKGLFQSGFLPGTNFLCPWIISRSVLLASDPFESTHEQFPTIAENRGKSSGRYKKENSVKAYIGIEYECPHGDRQRSSKTVFAQCMRIYVASPMDSDIRVILRPFIQPENETIYPPTDPKTPSKGRILKGLFHITAIVSDTSQNGKG
The following text describes a protein:
Function:
Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall. Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Midbody.
Sequence:
MATGDLRGNLERLRTQLLSVNYPHPFDVQGLKQGIPAVVLPLLHYALLGYSRHVARYLSANGYELYAKSDLRFMESALKFFRHEFNYRCALTIAQMFSRGYAERKMIFIYDAVQMTKRKHNELLKLGREKTIDKTELTQINYETMPGCGLGNAKVQAVDRLPFYEPKPWEHTLRSSKNPVRCSKDAECQLVDITVLPVPEPTSPRAPNSDSNVVHNQHGLCTEDSDKKSWELASRMRAKKLQPKAKKFVMSLQNSAEVPHPAASELSEGESEICQRIMDMADKLEARFSTLEDGVTRAKETLQEKLVGLEGRVQSLESVVSSKKQNQKLVHRSDFRDLSRNDFKQHTAACTTGELSQRESLIFGSPCTTKDPRQHDNYDHLSTCTSVESIRPKCNERAWSLSEKFQDSPRDACTGVPASKAIKSQAVRDISNTHQCVANTYGNIVGTSDVKLGEKGHTSLIQPGPVTSTREFIAGVRARFSRTLEVLLRNTFRLLAQ
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity (By similarity). May also bind DNA and function as a transcriptional regulator. Mediates polyubiquitination of QKI in macrophages, leading to its degradation.
Subcellular Localization:
Nucleus. Cytoplasm. Cell projection, axon. Nucleus, PML body. Note=Localizes to the PML nuclear bodies in Sertoli cells.
Sequence:
MDPSRSRSGGSGEESSFQENERRWQQERLHREEAYYQFINELSDEDYRLMRDHNLLGTPGEITSEELQQRLERAKEQLASQPGSDSAASDGDSESLRAHSDEDSLLRWLNTFRRTGNVTRSGQNGNQSWRAVSRTNPNSGEFGFSLEIHINPDNRGSEMHGEDSTDIPLSGVNREHRQQRPSSPVARRTRSQTSMSSSGPRGRRGARRQGSVQGSFATLGRLRNGIGVALGVPRVSAPRTNVINSHTNQSDGSTLRQGGRQRFGAAHIWENGARSNVTVRNTNQRLEPIRLRPAFSSRSRSPIQRQNGTVHHNSQRQGRPVQQTGRNRSVRHRGVTRVFLEQGREHRGTDYTPLSNSRLVSRITVEEGESSRSSAATQRHPAITLDLQVRRIRPGETRDRDSIANRTRSRAGLAESTVESTSGGFHRTISHLERSGVRTYVSTITVPLRRISENDVVEPSSVALRSILRQIMTGFGELSSLMEVEPASENQSNGQRLPEVYLELSNGDAADDSGQHGRASSQASQAQDGAEMLAVREPAPPQARPSGSRSRRQLGRADSVVEAGTLPILRLAHFFLLNEGDDDPIRGLTKEQIDNLSTRSYEQDGVDSELGKVCSVCISDYVAGNKLRQLPCLHEFHIHCIDRWLSENCTCPVCRRPVLEFGATSSG
The following text describes a protein:
Function:
Provides the (R)-glutamate required for cell wall biosynthesis.
Sequence:
MENIGRQRPIGVFDSGIGGLTNVRALMERLPMENIIYFGDTARVPYGTKSKATIENFSMQIVDFLLEHDVKAMVIACNTIAAVAGQKIRQKTGNMPVLDVISAGAKAALATTRNNKIGIIATNTTVNSNAYARAIHRNNPDTLVRTQAAPLLVPLVEEGWLEHEVTRLTVCEYLKPLLADGIDTLVLGCTHFPLLKPLIGREAGNVALVDSAITTAEETARVLAQEGLLNTDNNNPDYRFYVSDIPLKFRTIGERFLGRTMEQIEMVSLG
The following text describes a protein:
Function:
May act predominantly to suppress BCHC1, which itself is a negative factor in protein storage vacuole (PSV) trafficking regulation and plant effector triggered immunity (ETI). Required for ETI, but not for cell death.
Sequence:
MRGEDSDLCFDCLDQRINSDFSDQIVFSYGVSDSPLPFGSSAVVKVSDSSEEFSASCSSCESTSSQFILEYLRKDEHGCLAKYVDKFVVKDREGNSNDAVESDECLDCSTSGSQATEDDDTENITCGSVTCEHSGSFSCWRTVAALLPIAQIRKCSASELQKLASSFHYECPEDQILASLHRLIDGKSSGQATHSFLCLLLGLPLLEEKSKLRCLRHPNLSPVLGLLTSSDCLVSVLPKAPYTLENILYYSPSAIKSEWHRNFIIYQLLSALAHLHGLKVSHGDIRPSNILLSDSLWSWLTIYSKPDLGSVDANSSASRRRWCVEGCYSYGLYADLKISSHLDWQTHFDKWWKGELSNFEYLLVLNKLAGRRWGDHTFHPVMPWVIDFSKKPENDSDSGWRDLRKSKWRLAKGDEQLDFTYSTFEFPHHVSDECLSELAVCSYKARRLPLSVLRKAVRSVYEPNEYPSDMQRLYDWTPDECIPEFYCDPRIFCSLHPSMSDLAVPPWASSPDEFIRLHRDALESPHVSSLIHHWIDITFGYKMSGHAAITAKNVMLSSSEPTVPRSVGRRQLFFRPHPVRLGFSREKEQSRNELEMHTFHGFGVDNKRSVILLADEYLEETEEASAFSDHATHLCPKYHLRENLVESPLHVSYSENTKKVNTSLPGTSKNKGLSSRISLNYLLEHMEVRDEASTELQELLQWRQDFCTGNISKDIAGDIFSIGCVLAELYLMKPLFNSVSLATYLEGGDLPELIKELPPPTQVIVEACIEQDWRRRPSAKSLLDSPYFSATVRSAHLFAAPLQLLAKGQTRLCYAASFAKQGVLKVMGTFVAEMCAVYCLPLVTTPLSEDECELAYVLLKEFTKSLTPMAVQRLVLPSIQKILLTTGYSHLKVSLLQDSFVRELWNQIGKRVYLEMIHPLVISNLYNSPDKISASAASVLLIGSSEELGAPVTVHQTILPLISYFGKGICTDGIDVLVRIGRLLGVNFIVKQMLPLLEHVVCFCIDLSSMKKPEPVHSWCSLALSDCLITLDGLVALISDELLIHELTKGRLCLHVRVLMQKNLELRVLQFAATSLMSICQRIGQEMTALHVLPQLKELFDEFAFSEKSTDASDSLSWKIRTAEQKFHPESPIKSRMDLVLLLYPSFASLLGMEKLRQGCPTWLLLEQYLLKHHNWKWEYTGRSSRYNMEARPVLKQGPASKHTPKVLLNGSGRSVPQSQGLRNSNHLKLHIHVPVEGQEAVLNPLVHEPWSWFPSPVTCWDGLDIGRFGNPKDENRWKIRASVLSSARAHHGALRSLVVSEDECTVFTSGIDPGFKGSVQKWELASLSCVSSYHAHEEVVNDIGILSSTGKVASCDGTIHVWNSQTGKLISLFSESPSDQDQASSDPSSKNNSNPCNRHASHGLSSGIFDENLYTCMHYLEYMDQLIVGTGFGALRFIDLARGQKLELWGGEAIESGFTSLVSALCSGGSQTKHGDGASVSPSWIAAGFSSGQCRLFDLRENGFISSWRAHDGYVTKLVAPESHLLVSSSLDKTLRIWDLRKSWTPQPFVVKGHNDGVSGFSIWGKDVISISRNNIGIFSLAKSQDEEEQQQQRIIPQKLYMAEKGGRVKSDLSTICVLPFSRLFIVGAHDGHLRICC
The following text describes a protein:
Function:
Plays an important role in primary cilium assembly, maintenance, and length regulation. Interacts with centriole inner scaffold proteins to promote proper centriole size and integrity and assembly of functional cilia. Required for the recruitment of both the inner scaffold protein POC1B and the distal SFI1/CETN2 complex to centrioles.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to the inner scaffold structure of the central core region of centrioles.
Sequence:
MPGGMAPLKKPRNPTKLPLALNPTKSKDVLAVLAERNQAIIPVGAWVEPASPNWSGIPAHTSAYVVEEEIKEQQRRKQESLRHFQRQVRHRVNQRVKLRKKQQLHKSYKAAEKEGSIAMQYSDLAHLSSKRTSVFPSNLNAAVGRFRLPTSQVLGDAIEDGENQLFQQQAQALSQTMKQARHQLASFKTVSEKKTPVLPNGGRKGCPTQEGLGCGKISFVAVSEERDALFVSCQQDFLSEDKEKAFSKVQKVKFKNPLSVVIKEDERKQLHPHSLQAVLPEAQDYFVEVQSGLPESQSDVIDVQNVEPKASRIEPKTLGVEPDTQATGVECQTTEPEGQAVKTGIQDVPKVQTVELDGNTELEAQDFLPSHQAFLSRDTDCLPNCQYQDSLPKGHCVLPNYWNVLPKYQNQHFLPVDQEFLPRNQLALPKEQNHPLQCQKQDLLPREQFPLLLRHQDQREPHVLPKCQEHDVLSKAQNYLHNYQEQDLQLQNQEVNSKEPLSDITDGKGREIFSLDMFSKKPSTFMRRERGDEELPLDSPQCAPPQIQDQVFLREQSQQPSVRTAERWQEDLYLSGHECLPPRQRRDTCSRQQQVYEEYRSGLSTEQQALLAFQSGVDQEEDKKERQKQYLRHRRLFMDIEREQVKEQNRQRERKRRIEKIKKKKEQQRYAEEQRLLRMNCHEEPYSEEKISDVLAQLQLEEIKGAREKQQQREKEYIRYVEALRAQVQEKMKLYNITLPPLCCCGPDFWDAHPDTCANNCIFYKNYRAYNRALHSVINSSDISEGNATLRNAIRNFASAHRRTPKQSLH