lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine (By similarity). Together with psd1 and psd2, responsible for the majority of phosphatidylethanolamine synthesis.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Localizes at the barrier septum.
Domain:
The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.
Sequence:
MPFTKSCRSANTLRKGIKNGKLILKIIVNDIDNVESCLSGDESNDSKKSSASFYMKLKYGSYRALADNILSTDENRKEDIAVFDVPLPNGLQIDTFTLCLYRKSKWKKQIVGEAYIGIQALLLSTNPDETCKYPVISPPSGRNKENQSPSHQICNLSLKWIIYDPEDADADSKTLAKAWLQQIKMNQTSIDPMSNISKSLKELEVDNVESDLEDSSFIAEPDSSIPPSESSVSISTDTGKETPPSKSKKSSNQPYVSIGEGNSDLLGFVFLEIISVSNLPPLKNVFRTGFDMDPFVITAFSKNIFRTKWLRHNLNPVYNEKFLFEVGAFESNYDLVFKVVDHDKMSLNDSIAVGSFNVQSIINSSAQVDPETGLYSFNIETSSPSQDTSSKAEDSPTVQKIADDFSSAVGKDLRTDIIEQIIPLTLCCKHDFSTPRDVKLSFKAMFFPIAALRQKFWRVMLAQYGDIEDGHIGKLGMYAVLDTLGSNIPNSMVDDIYTELSSKNHDDTSDSITVDEAVICLERLVDLVCHQDQQATQTPQSPSSNEESGPGTPTQTSDQYEDSEDSRNFPSKLYLVYLSNCPLCLKFKLSKVNQQKATVHLATCASHDWKRVDRLMMTSYVSLNQAQRRWFSKAFAKVVYGSSKVGSTSATTLVQNRQTGQIQEEKMNAYVRIGIRLLYRGIRNRRIEGSKVKKILRSLTLKQGMKYDSPISVKEIKPFIRFFDLNMNEVDMPVGGFKTFNEFFYRKLKPGSRPCAFPDNPDILVSPADSRIVAYECIEKATTYWIKGTEFTVERLLGYSNEAQRFVGGSICISRLAPQDYHRFHSPVNGCIGPITKIEGQYYTVNPMAIRSYLDVFGENVRVLIPIDSNEFGKVMLVAVGAMMVGSTVLTVDEGKIVQRSDELGYFKFGGSTVITLFEPNVTSFDEDLLRNSKTKIETLVKMGERIGQKIDPNKPTDAEDHSKSDS
The following text describes a protein:
Function:
Required for the development of heart and visceral muscle; for the formation of somatic muscles. Has a crucial function in the early mesodermal subdivisions.
Subcellular Localization:
Nucleus.
Sequence:
MLQHHQQQAQSGGYYDHYTQSPSPGSLTNADALNTTPFSVKDILNMVNQTEAYEGSYGHIDGAATASALFAAGEYQNPHQYLNHQQHQQSELPIPQQQLHHQHLDDGATTSSSLSPLLPPPPHQLYGGYQDYGMPAHMFQHHHGHPHQSFQHSASAYNMSASQFYAGASATAYQTPATYNYNYAGSGEVYGGATPSAVGIKSEYIPTPYVTPSPTLDLNSSAEVDSLQAPTQKLCVNPLSQRLMETASNSSSLRSIYGSDEGAKKKDNSQVTSSRSELRKNSISGNSNPGSNSGSTKPRMKRKPRVLFSQAQVLELECRFRLKKYLTGAEREIIAQKLNLSATQVKIWFQNRRYKSKRGDIDCEGIAKHLKLKSEPLDSPTSLPPPIPNHVMWPPTMQQSQQQQQHHAQQQQMQHM
The following text describes a protein:
Function:
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
Subcellular Localization:
Cytoplasm.
Sequence:
MSWLEKILEKSNIVSSRKASIPEGVWTKCTSCEQVLYYAELERNLEVCPKCDHHMRMKARRRLETFLDQGERVELGEELEPQDKLKFKDSKRYKERLAAAQKASGEKDALVVMKGAVLGVPVVACAFEFSFMGGSMGSVVGARFVRAVEAAIEHNCGLICFSASGGARMQEALMSLMQMAKTSAALERLSDKGLPFISVMTDPTMGGVSASLAMLGDINIGEPKALIGFAGRRVIEQTVREELPEGFQRSEFLLEHGAIDMIVDRRDMRQRVASLLAKMTGQASPLVVSVNDAPNEVPYAVPEANKKG
The following text describes a protein:
Function:
Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
Sequence:
MLLYRLDIADFRVWVSIGVSEQERHYPQPVLVSLSLFFKEEPKACSTDKVSDSVCYAELVSLIEEVATNNPCALIERLAKVLLEKIEKALAGQVSRIDLRVSKERPPIPDLLSPVSFSISREVP
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKDNKMKKKPNKKGERRMGPDAVAMKAKTQKVDNPFESIRSRRKFDILGKKRKGEERFVSVSRTRAVDKRKNTLEKEYEQSLKSSVFLDKRIGEQNDELGEFDKGIIRSQRQRQLKLAKKSMYNLSDGEEDVYEDGALGGSSVKDDFDSGLLSDEDLQDDDLEASASKRLKHLNRNREVDASGEEERRKSKKEVMEEIIMKSKLGRMEKAKQKEEKGKLMDELDKNFKSLVNSEAMESLTKPFVAEENTRDPYLLSLNDMSMEIRARPSERTKTPEEIAQKEREKLEALEEERKKRMQETEELSDGDEEIGGEESTKRLTVISGDDLGDSFSVEEDKPKRGWIDDVLEREDNVDNSESDEDEDSESEEEEDDDGESDGGDEKQRKGHHLEDWEQSDDELGAELEDEEEDDDEEDDDEEDAELRVHKKLKNDYAAPYKGEGLSGTVKEKTNMKKMSSTQRDIPFMIDPPKNFEELLALVEDCSNEDVILIVNRIRIAHSIKIKAENRKKMQVFYGVLLQYFAVLASKKPLNFDLLNMLVKPLIEMSMEIPYFAAICARQRLLKTRSQFCEAIKNPEDGCWPSLKTLFLLRLWSLIFPCSDFRHAVMTPSILLMCEYLMRCPISSGRDIAIGSFLCSIVLLVAKQSKKFCPEAILFIRTLLMAASDKKSPASAESEFYHFMELKSLTPLLCIQDNVKEVMPLNFLKIMNEPADSPYFSSDDFRASILSSVVETLEGFVEINGGLSSFPEIFMPISTLLHQIGNQEKIPQTLKEKLEDVAKLIEKKTDDHHKERKPLSMRKHKPVAIRMVNPKFEENFVPGMDNDPDKYRSDLKKLKRKLKREARGAVRELRKDSYFMSTVKAKEKAAHEQERAEKHGKAWAFLQEQEHAFKSGQLGKGKGKKRRR
The following text describes a protein:
Function:
Plays a role in phenanthrene catabolism by catalyzing the oxidation of 2-carboxybenzaldehyde to phthalic acid. Not active with 3-carboxybenzaldehyde, 4-carboxybenzaldehyde, benzaldehyde, salicylaldehyde, 2-methylbenzaldehyde, 2-chlorobenzaldehyde, 2-fluorobenzaldehyde, 2-benzaldehydesulfonate, 2-methoxybenzaldehyde, 1-hydroxy-2-naphthoaldehyde or n-hexylaldehyde.
Sequence:
MTTPRKFDEYRWNVLVDGVPLNVESRYPISDPSTGRYLTQVPDCAEADVDRAVQASRQAQAEWGALPPRARAAKLRELITLLREHREEFAMLDAIDGGFPISMMRNDVDAALELMDIFADMALDLGGKTIPVSTNLHFTTHEPFGVVARIGAFNHPFFFAASKVAAPLMAGNSVILKAPDQTPLSSLRLAEVAAEVLPQNLLITISGRGRVAGRAIVRHPQIKRIGFIGSTDTGRSIQRDAAEVAVKHISLELGGKNAQIVFADADLEQAALGAVNGMNFTWTAGQSCGSTSRLLVHESVADQVIARVVELVSAIAVGPPLDENAQMGPLVSQAQYDKSVHAIGEGIREGAKVVAGGGRPEGVGEGGWYLAPTVLADVRPGSFIEQNEIFGPVLSVIIFATDDEAVAIANGVEYGLTASVWTSDITRAHLIARRVEAGYVLVNGGSRHYWGLPFGGVKSSGVGSEESMEELISYTETKTTTVVLG
The following text describes a protein:
Function:
Probably involved in the defense reaction of plants against pathogens.
Sequence:
MEIRTKFSCSLLGTFLLLSSLLPLSLSHLSDEVPSHVISRRLFTQTPSGAVRQYLIPHNILRAESGLPPLKWSKKLANFASWWAHKRQGDCALIHSNGNYGENLFWGSGKDWKPGDAVAAWAAEKSNYNYNSNTCTKNRDCLHYTQIIWRNSLKIGCAKVVCKSGDTLIACNYDPHGNVIGQKPF
The following text describes a protein:
Function:
Functions with mex-5 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos. Also affects formation of intestinal cells.
Subcellular Localization:
Cytoplasm.
Sequence:
MTATSNSAPLAGGSLSSSATAQPPQPPPGHQQQHPLPQIYDSQMQYYYGSSMPNQPIPTYTAQNGAPQQFGTPPYYQDANGQFGQVPAQQQMMTAGHPYFYMAQPQQGGQHVAQSGQPQIFYYQQPLGQMAQQAAPMYFHPMQAASTPMLSEQMSMMPQIQSTNPQQSEQLRKSGAQISTTRTVPLTSSTPLPTSREYETVQRDRNRNSQSRYQCPIEHDDLPIDEISKITIDNHNDDTMSAEKENRFNKNRVEKLGRRGFAKPEVDSQLPHNFKTRLCMTHAAGINPCALGARCKFAHGLKELRASDIPTRYPNNKYKTKLCKNFARGGSGVCPYGLRCEFVHPSDTEFQNIPPYQRKMVEEHDSIPEDYVVARYQPRFMHTSGKATTPTKVTLKQRNVAGSMMCLSNTGRDLEAGGDFNHPEINENDLPPHLRRIRRGNPPVTRSRPSFSTKWTSVENLGLRGHY
The following text describes a protein:
Function:
Component of the GID E3 ligase complex recruiting N termini and catalyzing ubiquitination of proteins targeted for degradation. GID E3 is regulated through assembly with interchangeable N-degron-binding substrate receptors induced by distinct environmental perturbations. Required for the adaptation to the presence of glucose in the growth medium; mediates in association with the substrate receptor VID24/GID4 the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MALDEKFQLEVIHLLLQFLNDYGYDESLKALEKETGLVSETEDVKRLKQAVLQGDWITAEAAFSIMQLRDESKRKEAQFLLQKQRCLELARSGAICEAIYVLQNFESTDFNKEKERLVSIILESNNKSNNELITKNGYGNTRLDLLNQLSEYISPEILLPKRRLEHLLQQAKDYQVSSQVYHNVLKNFSFLSDYKADPSELPTKEYHVFHDHSDEVWQISYSHNGRYLASASKDKTAIIFDVVNLKRVFRLIGHIDTVAYIRWSPDDRYLLSCSCDKSVILWDAFTGEKLRDYKHGFSVSCCCWLPDGLSFITGSPDCHITHWSLNGEILYKWEDVNIYDMALTSDGTKLYIVGFEQLINAEDKHIAIYSVETRECIKKISLQSKVTSICLSKDSKYALTNLEPHTTFLWDLEENRIVRQYMGHKLGNFLIGSCFGGKDDTFVLSGSEDDKIRIWHRESGKLLATLSGHVKCVNYVAYNPVDPYQFASAGDDNTVRIWSNKDNPRRQ
The following text describes a protein:
Function:
Transcription factor involved in the circadian clock and in the phytochrome regulation. Binds to the promoter regions of APRR1/TOC1 and TCP21/CHE to repress their transcription. Binds to the promoter regions of CAB2A and CAB2B to promote their transcription. Represses both LHY and itself. Recognizes the promoter of JMJ14 to regulates its expression during the night in a circadian manner. Binds to the promoter of BHLH80/FBH1 and regulates its expression in response to warm temperature, thus contributing to temperature compensation of the circadian clock.
Miscellaneous:
MISCELLANEOUS: CCA1 and LHY are only partially redundant, but they bind to the same region of the promoters.
Subcellular Localization:
Nucleus. Note=Moves into the nucleus very soo after translation. This translocation is unaffected by light and dark.
Domain:
The N-terminal part (11-82) is essential for DNA binding, an internal domain (136-316) is important for homodimerization and for interaction with LHY and the C-terminal part (317-608) is necessary for interaction with CKB3.
Sequence:
METNSSGEDLVIKTRKPYTITKQRERWTEEEHNRFIEALRLYGRAWQKIEEHVATKTAVQIRSHAQKFFSKVEKEAEAKGVAMGQALDIAIPPPRPKRKPNNPYPRKTGSGTILMSKTGVNDGKESLGSEKVSHPEMANEDRQQSKPEEKTLQEDNCSDCFTHQYLSAASSMNKSCIETSNASTFREFLPSREEGSQNNRVRKESNSDLNAKSLENGNEQGPQTYPMHIPVLVPLGSSITSSLSHPPSEPDSHPHTVAGDYQSFPNHIMSTLLQTPALYTAATFASSFWPPDSSGGSPVPGNSPPNLAAMAAATVAAASAWWAANGLLPLCAPLSSGGFTSHPPSTFGPSCDVEYTKASTLQHGSVQSREQEHSEASKARSSLDSEDVENKSKPVCHEQPSATPESDAKGSDGAGDRKQVDRSSCGSNTPSSSDDVEADASERQEDGTNGEVKETNEDTNKPQTSESNARRSRISSNITDPWKSVSDEGRIAFQALFSREVLPQSFTYREEHREEEQQQQEQRYPMALDLNFTAQLTPVDDQEEKRNTGFLGIGLDASKLMSRGRTGFKPYKRCSMEAKESRILNNNPIIHVEQKDPKRMRLETQAST
The following text describes a protein:
Function:
May function as a negative regulator of the EGFR/Ras/MAPK signaling pathway during eye development.
Sequence:
MSQRAKRPNRSDDGSVPVKRRKRTAAEEEEAASLAVWQPRSNDLKSIYNRTTTEAPAELFRKDLISAMKLPDSEPLASNEYWVIVDQWKQEWERGVQVPVNPDSLPEPSVTVTQNTPLKLQHEFKLPKNKYIRITKDENFKIEEHALSNAPAQSEAACSYDLDECDVSWLRILNSERSQCGQSPINSEQLERVIEQFELCCWDKIQSILRNEEGLGIEYDENVICDVCRSPDSEEGNEMVFCDSCNICVHQACYGITRIPEGQWLCCTCHLSKRPKCVLCPNKGGAMKCTRSGQKWAHVSCALWIPEVSIGCVEKMEPITKISSIPQSRWALICVLCRERVGACIQCSVKTCKTAYHVTCAFKHGLEMRAIIEDENADDGVKLRSYCEKHSKSSKNKEKSVCSGSEDDDSRRKKRKDMTSEEKNQARAARLQEIESEFFKHVSIKDVSIHLDVDNDALHHIYNYWKLKRKAGNNKPLLPPKSEDVDMLSHKREQADMEKMKMFVQLRQDLERVRNLCYMVSRREKLSRSFFRLREQTFYKQTAVLEAANNLPNVVVQAVIEANHGPSIYDRLYSHEDAEDHTSDFERILTRIAGVKSPTDSGDEKRTELNGLFKDKNPYKKIYFNGSSNRRSGSLYGSSSSSDEKDRLNAATTSEDEDKSKKKSSSSVRKPNNNNNKASDRRRKRHSASSKIESSSEEDSKQKTKKTWGQFSRLKQVERELGYSGSDSDELMPIRASQKSDTKQMSSIYSDSDSSDVSMTKASDSQQNKLRTKAAVKEFSHKPSTSNKTSPENKKNKKKESPTKKKDYDPSDLIVPQRQAAKKATENLKSTTTRVVKEQMDEPSVKVEEKPAKLPKPKAKTKETVKEVKEVKKESAVKTSDVFDLDKETDNAEILAYVPQRQAAKKAAEHIKSGLGKPVAPSSVDELEKNKLESTVVKKKEAEKQQPAKVPESKRKSSSNSSSSSSSSSSTSSSTSSSSDSDDEVPPSQQQAQQPRSESLFSNYSSKECRETAKRTNASKDWPFLDKGAKSAAAAASSSSTDSSDSSRPTSPIITTTTTTKTTSPDKKSTTTQREEQTRMRGKGRPATTAARGRPRQSSKSGDRVGDANVRLRNLSDSQRGDAKCRKGKQDEVAEKETKSVNKLQSPVRKTDKKLTESKESSEVSNLEKEILERKAGKQGSSKTKSTLDRLFGSPPDKKDEKKPLNKTTKPTKPERVKSTVKENKEPEKIASPVKKSPVKSKNIDEIFTQKTVLNENKIEVKEKEKHPTPKREEIEPAPKIEDFKQNNEKLTEPEKKLPHSRSIFSPPHLKDNLLDFDNLDDGFGISKDEEIMKGPLTFNFGNTSLFKEDSKEDSARETLNLVEKLRMEMSKKSTSCDVDDGASVSSSTKNECDRTEFAEQVVPNCVAEKNDAKVDDVPPPTVNLEMRVEVTEAKGFADRGQDYRFMSCEADVPLEQNKNIPIQQHHGLSDHGISGQGDERWVPPSEAYTAAPPIDPSNYGSESQQPLQTPQHFMQQYSLNKTQPLLNAIPPQIEMRLHDDTLKNPSPTLHDRRISQTPLNEDCMPSPSPYADIHPQAKWADSEIMPNRRSSSSSAASTSSSCSRRNDDDDLKLRPDVMMVNHQALEIGYLHPFPPELFPTLSDSSQFVSPVSLLHPPPLNPSLAFPSTAPAMLPPAFAPFPPAQVMAPTLSKPLEDVPHCTAAFTSSQHNMALTAAIANLPPSLPKEVEALPEDEVVPTTQSNVLSSPSPSIKSNSSGKKSPSKPTRTSARVTSQGKSPKQDVVKPSGRGRGEAKRNSVKSNAARGRGRARGRGRAHSHNDHEFISNTIHNKLVGTVYDLDFDDDISSENVDLKSMRERRKSVDVQKTELKESSDSPSQKKYNDLRELRPPSPVKDTTPKPAEVEPIFPDIVQPVLPGPVDMRTYNTNFDQSYNEANLLRAFDSGTTEPPVNEEIDEEFEKELQTALTTPSKKPDEPPANIKVSLSDSRNQLKVKIKGPIANYSSTIPPLPPPVTVSSISNNVISNNSIGVSSGTSNLRRMRKKELLRQYWTQDMNMDDSSCAPGFNATPTVPPVNRTIITIPKAVASMTSIPTKDDYRDYRTDDVIETKQHRKEAKSRPGALSRELRQLDLSLDEDALHERRRSIGSNNSTNYDSGTNKRRGRPPRPSQQTTGTPKIKIKIGNSIVGKIDDKRDRIRPPKKRLANINMPSVEDLKRESMKFRKLVMADFDEGKEKRKKKDKSEKRKRKKAKPEVRIISNESQNKLIIRIGKKGERTSGGEEGGAPIKLKLARCQEGSGYVMKSEEAAQSPPPPPPPPPPTLGPPPLPLNKDCEVR
The following text describes a protein:
Function:
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore microtubule attachments.
Subcellular Localization:
Chromosome, centromere, kinetochore. Note=Associated with the kinetochore.
Sequence:
MSVDPMAYEAQFFGFTPQTCLLRIYVAFQDHLFEVMQAVEQVILKKLEDIPNCEITPVQTRKCTEKFLCFMKGRFDNLFGKMEQLILQSILCIPPNILLPEDKCQETNPFSEEKLELLQQEIKELQEKYKVELCTEQALLAELEEQKTVKAKLRETLTFFDELENIGRYQGTSNFRESLASLVQSCRKLQSIRDNVEKESRRLETQ
The following text describes a protein:
Function:
Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. May be involved in lateral roots and nodules formation.
Subcellular Localization:
Cell membrane. Endomembrane system; Multi-pass membrane protein.
Sequence:
MAGNTATKNHLPNPHNQVFNVSVDVNQQGGSKCFDDDGRIKRTGTVWTASAHIITAVIGSGVLSLAWATAQLGWVAGPVVMFLFSFVTYYTSTLLSACYRSGDPATGKRNYTYTDAVRSNLGGAMVKICGLVQYLNLFGVAIGYTIASSISMMAIKRSNCFHSSQGENPCQINSNPYMIAFGVAEIVFSQIPDFDQLWWLSIVAAVMSFTYSTIGLGLGIAKVAETGKFRGSMTGISIGYVTQTQKIWRSFQALGDIAFAYSYSMILIEIQDTVKSPPSEAKTMKKATLVSVGVTTLFYMLCGCMGYAAFGDLSPGNLLTGFGFYNPYWLLDIANAAIVIHLVGAYQVFCQPLFAFIEKNAQERFPDSQFITKEIRIPIPGFHSFRLNLFRLVFRTIFVIITTVISMLLPFFNDVVALLGALGFWPLTVYFPVEMYIAQKKIPKWSTKWLCLQILSVACLIISIAAAAGSIAGVVLDLKSYKPFSTTY
The following text describes a protein:
Function:
Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity). Neuronal receptor for LGI1.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, axon.
Sequence:
MQAAAAASFWLLCVLGTCPLARCGRAGVASLKGLERGKENRFLERQSIIPLRLIYRLGGEDETQHNQLDTRVRGDPGGPQLTHVDKASFRVDAFGTSFVLDVLLNHELLSSGYVERQIEHGGKVVENKGGEHCYYQGQIRGNPVSFVALSTCHGLHGMFYDGNHTYLIEPEENEKSQESSHCHSVYKSRQFEFPLDDLPSEFQRVNITPPQFILKPRLKRRKRQLLRFPRNVEEETKYIELMIVNDHLMFKKHRLSVVYTNTYAKSVVNMADVIYKDQLKTRIVLVAMETWAADNKFAISENPLITLREFMKYRRDFIKEKADAVHLFSGSQFESSRSGAAYIGGICSLLRGGGVNEFGKTDLMAVTLAQSLAHNVGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNVEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECALEGAECCKKCTLTQDSQCSDGLCCKKCKFQPLGTVCREAVNDCDIREICSGNSSQCAPNVHKMDGYSCDGTQGICFGGRCKTRDRQCKYIWGQKVTASDRYCYEKLNIEGTEKGNCGKDKDTWTQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGAHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCSSSKAGTVCSGNGVCSNELKCVCNRHWTGADCGTHFPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGDGDSFYSDFPPGGSTNSASSSKKRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNMGGNKKKIRGKRFRPRSNSTETLSPAKSPSSSTGSIASSRKYPYPMPPLPDEGKTAGRQSARLWETSI
The following text describes a protein:
Function:
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3) (By similarity). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, another proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis (By similarity). Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C (By similarity). Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability (By similarity). Promotes cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels (By similarity). Phosphorylation of CDKN1B, induces 14-3-3 proteins binding, nuclear export and proteasome-dependent degradation (By similarity). May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3 (By similarity). Also acts as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis. Acts as a positive regulator of mTORC1 signaling by mediating phosphorylation and inhibition of DEPDC5 component of the GATOR1 complex. Acts as a negative regulator of innate immunity by mediating phosphorylation and inactivation of GBP1 in absence of infection: phosphorylation of GBP1 induces interaction with 14-3-3 protein sigma (SFN) and retention in the cytosol (By similarity). Also phosphorylates and activates the ATP-binding cassette transporter ABCG2, allowing resistance to drugs through their excretion from cells (By similarity). Promotes brown adipocyte differentiation.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Initiates from CTG codon.
Subcellular Localization:
Cytoplasm. Nucleus. Cell membrane. Note=Mainly located in the cytoplasm.
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVADNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSDFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEDLARGFFWQVLEAVRHCHNCGVLHRDIKDENILIDLSRGEIKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIKGQVFFRQTVSSECQHLIKWCLSLRPSDRPSFEEIRNHPWMQGDLLPQAASEIHLHSLSPGSSK
The following text describes a protein:
Function:
Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Due to intron retention; MISCELLANEOUS: [Isoform 3]: Due to intron retention.
Subcellular Localization:
Golgi apparatus.
Sequence:
MAAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKVSGEASVTVPTIDTYLLHSQGPQTPNIRVSSGTQRKRQFSPSLCDQSRPRTSGASYLQNLLRVPPDPTSTESFLLKGPPSMSEFIQGHRLSKEKRLTVAPPDCQQPAASVPPQCSQLAGRQDCPTVSPDTALPEEQPHSSSQCAPLHCLSKPPHP
The following text describes a protein:
Function:
Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.
Subcellular Localization:
Nucleus.
Sequence:
MGERKVLNKYYPPDFDPSKLPRARRPKNQQMKVRMMLPMSIRCNTCGNYIYKGTKFNSRKEDVIGETYLGIQIFRFYFKCTKCSAEIAMKTDPQNSDYTVESGATRNFEPWRAEDEEAEKERQKRESEEMGDAMKSLENRTLDSKREMDILAALDEMKSMKSRHATVSVDAMLEALQHTAAEKEKKLEEEDEALIKSIFQRPKEVVRRISDEVFSEDGDLTHLSSGNGETSNDGLKRRKVSEEASNNPTDALTKASVLDSSSSKENSSVSGTRQGKVPFKPSIMISVVRKPEEKIANSTSTGLQSLCQNYDSDDD
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MSSRAGTGAPAPDDKITALKKVLYDECFESFEDNPTFFQEDLFELNVLPNDDVSILLAVTQGLTNDKLFKVVQDSQRGIGWKLRTQEEAKNYRSLSSEQEIVYALIDEAAEEGIWTKTIKARSNLHDAVFRTALKHLETKHLISEMKSVENRNRKMYIKSSLQPSDRATGGAWYTDNELDEEFITQISHILFDHIHRKSFYKSSSASLKKPKKVVGRKMSADEAKALRDKALGGRVKIEDTTEDDAVDGARRHYDALLPMPPGYQGYPTLNELTSFIENSGATAMTLTAQDIQQLLEILIFDNKIEKVLAGPEGVCYRAVRKGFREDQEGGPSSALTDVPCGHCPVADLCEEGGPVGPSTCEYFQTWLNI
The following text describes a protein:
Function:
May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (By similarity); [Isoform 1]: May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation (By similarity). Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (By similarity).
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Inactive. Lacks the active site.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MGNGMTKVLPGLYLGNFIDAKDPDQLGRNKITHIISIHESPQPLLQDITYLRISVSDTPEVPIKKHFKECVHFIHSCRLNGGNCLVHCFAGISRSTTIVIAYVMTVTGLGWQEVLEAIKASRPIANPNPGFRQQLEEFGWANSQKLRRQLEERFGEIPFRDEEDLRALLPLCRRCRQGSATSAASATTASSAAEGTLQRLVPRSPRDSHQPLPLLARVKQTFFCLPRCLSRKGGK
The following text describes a protein:
Function:
Mainly functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates. Can mediate the levels of long-chain fatty acids (LCFA) in the cell by facilitating their transport across membranes (By similarity).
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MAALLLLPLLLLLPLLLLKLHLWPQLRWLPADLAFAVRALCCKRALRARALAAAAADPEGPEGGCSLAWRLAELAQQRAAHTFLIHGSRRFSYSEAERESNRAARAFLRALGWDWGPDGGDSGEGSAGEGERAAPGAGDAAAGSGAEFAGGDGAARGGGAAAPLSPGATVALLLPAGPEFLWLWFGLAKAGLRTAFVPTALRRGPLLHCLRSCGARALVLAPEFLESLEPDLPALRAMGLHLWAAGPGTHPAGISDLLAEVSAEVDGPVPGYLSSPQSITDTCLYIFTSGTTGLPKAARISHLKILQCQGFYQLCGVHQEDVIYLALPLYHMSGSLLGIVGCMGIGATVVLKSKFSAGQFWEDCQQHRVTVFQYIGELCRYLVNQPPSKAERGHKVRLAVGSGLRPDTWERFVRRFGPLQVLETYGLTEGNVATINYTGQRGAVGRASWLYKHIFPFSLIRYDVTTGEPIRDPQGHCMATSPGEPGLLVAPVSQQSPFLGYAGGPELAQGKLLKDVFRPGDVFFNTGDLLVCDDQGFLRFHDRTGDTFRWKGENVATTEVAEVFEALDFLQEVNVYGVTVPGHEGRAGMAALVLRPPHALDLMQLYTHVSENLPPYARPRFLRLQESLATTETFKQQKVRMANEGFDPSTLSDPLYVLDQAVGAYLPLTTARYSALLAGNLRI
The following text describes a protein:
Function:
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity). Phosphorylates PFKFB2 (By similarity).
Sequence:
MEPPRGPPASGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSIQDLSGGSRQQEVPSNLSVNELLTPQGPSPFTQQRDQEHFSFPAPANPPLQRIRSTSTPNVHMVSTTAPMDSSLMQFTAQSFSTDAAGRGGDGAPRGSPSPASVSSGRKSPHSKLPAEQRERKSLADEKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAMRRLLTDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP