lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in cellular morphogenesis. Required for traffic between late Golgi and early endosomes, and for the normal structure and organization of the endoplasmic reticulum (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein. Note=Late Golgi.
Sequence:
MNTIIDASNDAKYRKYQDAIRKCIALFQTVEQWPDYISFLTKLHKVLQTHSSFVNIPCSLLVSRALAECLSPGLPSGVHKKTLEVYDYIFTIIGSKTLTNELSTWSYGLTPFFSISSIKTKHDYINIIKKHYVSLGVGIRPCFQAVFISLLSGLEEDVDESSQEVYHLLDDLVKVLNDEKFAWGCIWSTILSFPSQRPGALAYLLRVCNNLAEEDIQTRVIQPDSGLVVRSFAAAISDNDILVQRGYMDALLNYFPIQSTFYKDVKPFDLKLLHMSVASIVLRNDLSLNRRFYAWLMGLSKDTELSISDSSITVDENTLQQNMAIFFEGVKDLLSSKNSLMSFYKAFRILYALSDRRPLFTIVESQILPCVLHSYETLTNVFHRDDSKHLYESAVDHGRRLIMKFSDSELHTFLFHCVNKIVANTTENSDSAEAVKFILDSQNFFFESINTEYSFIIFTNLLMHLEKTSPNSDVDGVSMTILTICKILLNNFDWNFFNYNNSAIDSYAKCTLNLDSDFENGILTYEILYKKCKCSLLSLLKQYIKDSHVHHEVLLISLNLIKEASDTEFENEFLDLSLQGFKDNSWSFQTLGSFVKQLPSRILINSTACVNVILDRIWCELCMFSYFREEELLSVIWTLQEKLQTRIIESYFSTCIVKEQLELRAPTIYYTPFYNLLKKSAQQSLFHFVFDRPLLLLLNSLLEDESGRDYTAMMNWINASSSLQLRVLELMTENLLSLSPNLTSVNSLETAMTRYNINEDQRNSEASRCVYFLKLCTRIISYFQDLHPKEGRLKSAKQVEELCLVTWADALLIQKKSLTYSSFLAFLVKLCLDIVLTPQNIKTSTDVYIIQTWALRLLYQITSIWENPLKFESSLIVGLFALVQEVERSPSSTYRSFILSLLQMLEFLLSRLDGTIDLSSEQHYLLSNFVLVGMLNDDPGLSPKWLHAIKKLLPLLLQNLQLLMVNPIQSLCKFVHSFLDQHESMYLKYPDPVKDYACMDVFIAKLKMLSELVSAALLEFTYSPGPKKSNLEANGIIGNVISGVFAAESSGVSIDVNKRLSMLLTMQDALQTLFLSYSWHIRSSYADKTSKVFMNDSSVLKEASLSGLKEFYFCEPLECVETLVQIYLENNVECCQCIWDIFSFLSDSEPQYIVKQLVSSFFAREGIASYAGPSSLTAKITQLDILCCMSDFVSRVEGENTSKIFTEISKFVREIISSSNSFKNYLLVCLRMLLEVAKNVNTYCESRQQKDFIDLMGKTLSSVLFHAGKSSDPNLTVDFLAYHKAAADTFEVAKTQKKTSSVYLFVKYLDPSLLDFFCSEFVPKITELSKEEDKLVAWATSIVNVFITPLVKARTFPESLTTYHLDLLLVLSKHPFLSKSWRRDFWEIFNDNSLFRFDIDQLRKLSPVIYTALYQEISRLNDLITKSDLGVTTLFTSRDTQLGARQSNICRITILMLSSPRDFFLPSLPPLIDLVKRLITSDPEGVLKKDLFLFIRALALRTSSKHLLPLWPIVVSELLIIFKSYCMPNVAISKETLLDACRLLDFLTALKLEEFALHEWVVMLSPLDAVYWSGKTSRKSLVQKVSERLQEQASEKDDKSSVESEHSILTSTTRTPSLGIYTTDAQLRNFLNRISIDAYEESYSFSTIDIQSFENSIYREVLQRFSNAPLSPFSSIKAPSSLAGSSN
The following text describes a protein:
Function:
Histone methyltransferase that monomethylates 'Lys-5', 'Lys-8' and 'Lys-12' of histone H4 (H4K5me1, H4K8me1 and H4K12me1, respectively), thereby controlling gene expression and remodeling chromatin structures.
Subcellular Localization:
Nucleus. Chromosome. Cytoplasm.
Sequence:
MLGLRDVCFDPMLSSYDYHPISLMSTVPNDREIVQAVVDIWRKDKATEKLGAAKLTGLVKLTHSDWQLSEKRVKTVMKAANLGLNQEKFCYAGSIMSHATPGLDMPEKVTLNIAKNRGKGLYAKKDIKKDEELWNEQAFLLVPPLEHVGIMRKGMGCAFCSRPFQSHNGVECPSCAAKWCDNQCKKKDVTHVAMWHESRHGKVTRVEWRAFEDFCVENGWMALYALGLLWLRVIRDPKKDEVQKQMMAFARVGQDERHKAVEQSNSLFASEQSEVLWKKGYEMLDKLLLDTEFSYEKDFLPGLGMFNINNVDGNMYLTQSHLNHSCEPNVDVKNVGRTQGISVRAKRDIKTGEELFTTYVNPEHQLDDRRYNLRVNWGFNCNCTRCKREEREEMEYLDELVSNWTIEHKRKEMKEEKKERTRTRTRSVHFDKEPEVVA
The following text describes a protein:
Function:
Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.
Sequence:
MKSPVKRDCERDNTMSVNKIFTLVFLKKNSEVLLGYKTRGLGRGLWNGFGGKVEKNETIANCAKRELEEECSLVAKDLKHIGVVRYDLPYENSADIVHIFTCSQYDGCEKASEEMDPIQWYDFSAIPYAKMWPDSPQWYPLMLKEKFFAARVTYSDPDTITDTKIEEFEDLASALKVAN
The following text describes a protein:
Function:
Catalyzes the stereoinversion of LL-2,6-diaminopimelate (L,L-DAP) to meso-diaminopimelate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
Subcellular Localization:
Cytoplasm.
Sequence:
MEFWKLQGSGNDFVVIDDRDEKLESFLKERGVSKEDFVRKVCAFHTGVGADGLILIKNPDNPENDFKWEFFNSDGSVAEMCGNGSRCAVRFAYERGIVGNKVRFETLAGVIKAEVYENGRKVKVQLTPPSKPEEKTLTVDGEEVIGVFINTGVPHFVVPVEDVEKVNVIKLGRAIRFHEEFQPKGTNVNFVQPVSEDTIKVRTYERGVESETLACGTGATACAIVSYLKGLVKKKPVNVLTRSGEVLTIDFSEDLKEVFLTGSVYKVFEGRLSEEVLEY
The following text describes a protein:
Function:
Serine protease which plays an essential role in merozoite invasion of and egress from host erythrocytes by processing and activating various merozoite surface and parasitophorous vacuole proteins. Mediates the proteolytic maturation of serine proteases SERA4, SERA5 and SERA6 just prior to merozoite egress. Prior to merozoite egress, cleaves merozoite surface proteins MSP1, MSP6 and MSP7, which form the MSP1/6/7 complex, and thereby may prime the parasite cell surface for invasion of fresh erythrocytes. Prior to merozoite egress, cleaves MSRP2 converting it to MSRP2 p25 form, and RAP1 converting it to RAP1 p67 form.
Subcellular Localization:
Secreted. Parasitophorous vacuole lumen. Note=At the schizont stage, in merozoites, localizes to dense secretory granules called exonemes. Just prior to egress secreted into the parasitophorous vacuole (By similarity).
Sequence:
MMLNKKVVALCTLTLHLFCIFLCLGKEVRSEENGKIQDDAKKIVSELRFLEKVEDVIEKSNIGGNEVDADENSFNPDTEVPIEEIEEIKMRELKDVKEEKNKNDNHNNNNNNNNISSSSSSSSNTFGEEKEEVSKKKKKLRLIVSENHATTPSFFQESLLEPDVLSFLESKGNLSNLKNINSMIIELKEDTTDDELISYIKILEEKGALIESDKLVSADNIDISGIKDAIRRGEENIDVNDYKSMLEVENDAEDYDKMFGMFNESHAATSKRKRHSTNERGYDTFSSPSYKTYSKSDYLYDDDNNNNNYYYSHSSNGHNSSSRNSSSSRSRPGKYHFNDEFRNLQWGLDLSRLDETQELINEHQVMSTRICVIDSGIDYNHPDLKDNIELNLKELHGRKGFDDDNNGIVDDIYGANFVNNSGNPMDDNYHGTHVSGIISAIGNNNIGVVGVDVNSKLIICKALDEHKLGRLGDMFKCLDYCISRNAHMINGSFSFDEYSGIFNSSVEYLQRKGILFFVSASNCSHPKSSTPDIRKCDLSINAKYPPILSTVYDNVISVANLKKNDNNNHYSLSINSFYSNKYCQLAAPGTNIYSTAPHNSYRKLNGTSMAAPHVAAIASLIFSINPDLSYKKVIQILKDSIVYLPSLKNMVAWAGYADINKAVNLAIKSKKTYINSNISNKWKKKSRYLH
The following text describes a protein:
Function:
Involved in the regulation of root hair growth.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSRERIKRELPPVQEHIDKLRKVIEEGNYYGALQMYKSISARYVTAQRFSEALDILFSGACIELEHGLVNCGADLAILFVDTLVKAKSPCNDETLDRIRCIFKLFPRVPVPPHLVDVSDDEDVQNLQESLGEARSRVENLTSFLRAAIKWSAEFGGPRTGYPELHAMLGDYLYTECPELDMVRISRHFVRAEDPEKFASMLVNFMGRCYPGEDDLAIARAVLMYLSMGNMKDANFMMDEIKKQAETKNPELSESDLIQFISYLLETLQRDALPLFNMLRVKYKSSIDRDQLLNELLDEIAERFYGVQRKNPLQGMFGDIFKMMG
The following text describes a protein:
Function:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex); As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A.
Subcellular Localization:
Nucleus. Note=Localizes to sites of DNA damage.
Domain:
The BC-box, which mediates binding to the elongin BC complex, has the consensus sequence [APST]-L-x(3)-C-x(3)-[AILV].
Sequence:
MAAESALQVVEKLQARLAANPDPKKLLKYLKKLSVLPITVDILVETGVGKTVNSFRKHEQVGNFARDLVAQWKKLVPVERNNEAEDQDFEKSNSRKRPRDVPQQEEEAEGNYQESWQASGSQPYSPEHRQKKHRKLPELERPHKVAHGHERRDERKRCHKVSPPYSSDPESSDYGHVQSPPPSSPHQMYTDLSRSPEMDQEPIVSHPKPGKVHSNTFQDRLGVSHLGEHQGKGAVSQNKPHKSSHKEKRPVDARGDEKSSVMGREKSHKASSKEESRRLLSEDSAKEKLPSSVVKKEKDREGNSLKKKLSPALDVASDNHFKKPKHKDSEKIKSDKNKQSVDSVDSGRGTGDPLPRAKDKVPNNLKAQEGKVRTNSDRKSPGSLPKVEEMDMDDEFEQPTMSFESYLSYDQPRKKKKKVVKTSGTALGEKGLKKKDSKSTSKNLNSAQKLPKANENKSDKLQPAGAEPTRPRKVPTDVLPALPDIPLPAIQTNYRPLPSLELISSFQPKRKAFSSPQEEEEAGFTGRRMNSKMQVYSGSKCAYLPKMMTLHQQCIRVLKNNIDSIFEVGGVPYSVLEPVLERCTPDQLYRIEECNHVLIEETDQLWKVHCHRDFKEERPEEYESWREMYLRLQDAREQRLRLLTNNIRSAHANKPKGRQAKMAFVNSVAKPPRDVRRRQEKFGTGGAAVPEKVRIKPAPYTTGSSHVPASNSSSSFHSSPEELAYEGPSTSSAHLAPVASSSVSYDPRKPAVKKIAPMMAKTIKAFKNRFSRR
The following text describes a protein:
Function:
Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1. Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation of UQCRFS1 into the complex III and whose presence is detrimental for its catalytic activity.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MFRLLSWSLGRGFLRAAGRRCRGCSARLLPGLAGGPGPEVQVPPSRVAPHGRGPGLLPLLAALAWFSRPAAAEEEEQQGADGAAAEDGADEAEAEIIQLLKRAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYTYDLMANLAFIRGQLENAEQLFKATMSYLLGGGMKQEDNAIIEISLKLASIYAAQNRQEFAVAGYEFCISTLEEKIEREKELAEDIMSVEEKANTHLLLGMCLDACARYLLFSKQPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQINHPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQAKLKKDEISVQHIREELAELSKKSRPLTNSVKL
The following text describes a protein:
Function:
Voltage-gated chloride channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKDDQLIDWIHERYEEQKSANRLAGRFRFLGLETKYSIISIISGIFIGLTAALLNALASLLNSFREGYCTVNILFDKQTCCSTLTEDYECQEFFFWRNNHSVFVSCLIYVSVSVGFAFIATTLGYVVAPAARASGIPTIKAILSGYKYPDMNVFFSIKTLCSKSLAVCFSVASGLWVGKEGPFVHIATNIIYLVERIAPSLADSEIFTRQLLAAAMASGIAASFNAPVGGVIFALEQLASSSFPSLFTGSIWYEFLCSASSVVALQLIRSWHTDVGYLSYVSLDRRWSYKDTLPFIFISILCGCLGSVLIYLNMKFASKTKGFSKISNVFFVIFLSLITSLTAYAILGESELLFNPMELFPQVINSCSPSSSTVLCETTFWVTAIVLFTSALLGLLLTSATFGAAIPTGIIVPSLAIGACIGRAVGTLLKSRFPSLAGTSIYGVIGSIAFLSSTTRLVVALVVILFELTGALNIALPLMLATLISKWVSDSIIETSIYDAWIQFRNIPYFPSSNSLKFSIPLNFPVRSPEQLVRLPIRSCSIEELERAMHDSSQSFFVVLKNDTEFFEGFISRNKVSELLNRRPMSSNMQTTDNTGLDPLRSASAPVDSTFDLFDYIHPTTFTLNYDTPPVLMLKLFKDAGITNLALLNHGKLHGVLTKIDIIEYAKKCKTHTGNTYSELPTGVTYETDIFNRADD
The following text describes a protein:
Function:
Required for photoreceptor cell morphogenesis. Mediates homophilic cellular adhesion.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Extracellular side. Note=Extracellular surface of R-cell plasma membrane.
Sequence:
MGLEFFFKFGYAFLTITLMIMIWMSLARASMFDREMEETHYPPCTYNVMCTCSKSSTDLGIVHCKNVPFPALPRMVNQSKVFMLHMENTGLREIEPYFLQSTGMYRLKISGNHLTEIPDDAFTGLERSLWELILPQNDLVEIPSKSLRHLQKLRHLDLGYNHITHIQHDSFRGLEDSLQTLILRENCISQLMSHSFSGLLILETLDLSGNNLFEIDPNVFVDGMPRLTRLLLTDNILSEIPYDALGPLKSLRTLDISHNVIWSLSGNETYEIKASTKLNLDNLHLEYNHIEVLPPNSFKYFDTVNRTFFDGNPIHTLREDAFKPARIREIYMRYCGLTNISPVAFDSLVNSLQILDLSGNNLTKLHHKLFNNFDVLRVISMRDNKIKIQKPTETFNAVHYTLLKLDLSGDRNDPTNLQTLRNMTRMRNMRSLSISRLGSSSVGPEDFKDFGVELEDLQITRASLSGIQSHAFKHVRGLKRLDFSENGISSIENDAFHEIGHSLISLKMSHGYSGSALPAEPLRHLTSLQELDFSNNHISSMSDTSFHFLKNLRLLELHDNRIEQVLKGTFQGDIHSKLEEISLRFNHLTSISQHTFFDLEALRKLHLDDNKIDKIERRAFMNLDELEYLSLRGNKINNLADESFQNLPKLEILDMAFNQLPNFNFDYFDQVGTLSNLNVNVSHNQIRQLMYNSSWSGRNEHGGMYHSNIKILDLSHNNISIIHPGYFRPAEISLTHLHLGYNSLMNTTRDVFGNMPHLQWLDLSYNWIHELDFDAFKNTKQLQLVFFGHNYLSDIPQDIFKPVQGLRIVDFSHNHLRGLPDNLFYNGGMEKLDVSHNMMLKIPSSSLSSLAALTLCELHLSNNFISTIHSMDLSNKFRSLRYLDISYNYLLRIDDAVFATMPKLAVLDLSHNRDLKVMDKSFMGLENSLIKLGLENISLSTVPEIRLKYLREFRLGYNELPSIPQELAHNMSNLRMLDLSNNDLTNVPLMTQALPHLRRLMLSGNPITSLNNNSFDGVNEDLEMLDISNFRLHYFEYGCLDSLPHLRSLKLTAYSHLEHFNIPHLLRHHYNIRQLWIEAPQPFTRIVKKGSGPTQEMQTLQLGNPTDLQREMEGHLPSKLTNITFSGPQFTNLNERILRGMRSPYLYMQLFNTSLQALPPNFFKYMGRVRNISLDIRYHNRNLKKIPNPNTGAVPYLPNSVFLTDLKMSHTDLNCDCDLGWVEFWQRKRRQYICSSQTWTDTVFRTFMNSPCQVYGRHNCDEHDDDLRETRCENKGGQQLMEALKFDLECGWDNANCREAAFVVVMVCVAMVFWM
The following text describes a protein:
Function:
Involved in the efflux of purine ribonucleosides, such as inosine and guanosine. Adenosine may also be a substrate. Confers resistance to the hypoxanthine analog 6-mercaptopurine, however the level of resistance is rather low.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSEFIAENRGADAITRPNWSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAAAVMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNLAGFGVDGLTLVLLSFGIASFIGTSLSSFILKRSVKLALAGAPLILAVSALVLTLWGSDKIVATGVAIIWGLTFALVPVGWSTWITRSLADQAEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVTAKVKMKKS
The following text describes a protein:
Function:
Component of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs). Sgf73 tethers the DUB module to the rest of the SAGA complex through its central domain and activates the ubiquitin hydrolase ubp8 by maintaining its catalytic domain in an active conformation. Sgf73 mediates recruitment of the TREX-2 mRNA export factors sac3 and thp1 to SAGA, which is crucial to target TREX-2 to the nuclear pore complex (NPC) necessary for export of mRNA. Upon environmental stress, involved in the bypass of the canonical mRNA export process for the immediate export of stress-related transcripts to maintain proteostasis (By similarity). Independent on its function in SAGA, promotes the assembly of the RNA-induced transcriptional silencing complex (RITS) and is required for pericentromeric heterochromatin silencing and the generation of siRNA.
Subcellular Localization:
Nucleus.
Sequence:
MLTEQQTLELFPENWERNEQVLLKYPDGLPKDVLADQRVDNTESQVKDEITSNITNQTQILLPADSFPQYGSYPNNSELDYVVCTKCDRPFLSEYIEDHHSSCNGIKPPKPQFEPVANSQVLNKDVNNGNNAPIKNGVKSTAKGSAGNHEKNSVNGQKNPEMPPKRRKTEENKKPTKSALPKKEASKKKNPKVKGPVDVEKQCGVLLPNGQMCARSLTCKTHSMSSKRAVPGRSQPYDVLLAACQKKNQVKIQRQILETAKESEDNQHQAPVDSDEEVSFIMNVLQKSGNQPLEQKVFLPVKRRHSYFRTRELIAAAFRHGEQGMQVTGTILGRVIPFSARQPL
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Sequence:
MGARKRHSPRRGSLAYSPRVRAKSMEARIRAWPKLDSEEPKILAHCGFKAGCVQIVSIDDREKVPNAGKQLVSLGTVLVTPPVLILGIRGYSKDHDGLHAEFDVYAEDIPKSIAKEISLKNKQENALDNAEKSLKKIKEIFAIVAISPSAAGLEQKKPYIFEASVSGGDIPKQFAHVKELLGKEIKIDQIFETGASVDVAAITKGKGWQGVLKRWNVKKKQHKSRKTVREVGSLGPISPQSVMYTVPRAGQFGFHQRVEYDKRIMIMGNTDDDKLKINPDGGFKHFGLVKGDFIVLKGSVPGAYRRLIKLRSQIRNVPDKVNKPNILEVVV
The following text describes a protein:
Function:
May play a role in ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MAAGSNRGGDKRGSKSQADSNFLGLRPTSVDPALRRRRRGPRNKKRGWRRLAEEPLGLEVDQFLEDVRLQERTTGGLLAEAPNEQLFFVDTGLKKKEPRKKRTWVQKKSKHLQKPLRVDLALENHSKIPAPKDILAHQVPNAKKLRRKEELWEKLAKQGELPRDVRKAQARLLNPPAPKAKPGPQDIIERPFYDLWNPNNPLDKPLIGQDAFFLEQTKKKGVRRPPRLHIKPSQVPAVEVIPAGASYNPTFEDHQALLLEAHEVELQREKEAEKLERQLALPTAEQAATQESVFREMCEGLLEESEDEDGPGCAEQPEADDGATETSPTGAAGPEKRMEKKTEQQRRREKAARKLRVQQAALRAARLQHQELFRLRGIKAQVARRLAELARRKEQRRIRRLAEADKPRRLGRLKYQAPDIDVQLSSELSDSLRKLKPEGNILRDRFKSFQKRNMIEPRERAKFKRKYKVKLVEKRAFREIHSTLCPQVVAVQMLEPLPLNKVL
The following text describes a protein:
Function:
Catalyzes the transfer of a methyl group from AdoMet to arsenite, producing methylated arsenicals. Involved in the conversion of As(III) to a number of methylated products. Reduces the arsenic toxicity in the cell and may contribute to the global arsenic cycling.
Sequence:
MDAAEKKEVIKKKYQEIATLGGSCCSGGGCCGDLSAADLSRSLGYSEADVQAVPDANLGLGCGNPTAFAELKPGDIVLDLGSGAGFDSFLAAQRVGSLGKVIGVDMTQEMVKKAQDNARKYGYSNVEFRQGDIEALPLDDRSVDVIISNCVINLAPDKEKVFREAFRVLKPGGRMYVSDMVLLEDLPEDLKNDCDLLAGCVAGALLKEEYLGLLKKAGFSFKILAEDSDVSKRQYEGLPVESLKLKAWV
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MDYLVALLQTRGHSLDVDTIDRVRYLHFPRVLSALAVFLFTRSYVGEPVQCWLPRQFTPFWEQYVETYCLIEGSYYVNVNDTNIPGAEGKRKIIYYQWIPFIVLALAAALYAPRVIWRLYQKKSGLDVSSVATDLKKRAKQLADTKIHLDSSRFSSNLAAVIVFHKILSLVIIVLLLFMLEHFFGVGWALEQTTNLFRGREWHESAQFPRVTFCDAEVREMGGQVHTWTVQCVLMVNMFNEKIFFFIWWSLIVIFVLTALNILDWIFFMLNRSEQKRVIMALIEKNTKTSKSMEDAFVTYVMRRSGASFVRLLSFSVSHFEMEEVVRPLWEDYLTAREKKTDGDDKPYIDDDDL
The following text describes a protein:
Function:
Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids.
Subcellular Localization:
Peroxisome.
Sequence:
MAAEKWVYMVTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPSFDRDRMWLNGKEISLSGSRYQNCLREIRGRAGDVEDKEKGVKIEKKDWEKLHLHIASHNNFPTAAGLASSAAGFACLVFSLAKLMNVDEDASHLSAIARQGSGSACRSLFGGFVKWEMGSKEDGSDSVAVQLADEKHWNDLVIIIAVVSSRQKETSSTSGMRESVETSLLLQHRAKEVVPKRTLQMEEAIKNRDFASFTQLSCADSNQFHAVCLDTSPPIFYMNDTSHRIISLVEKWNRSEGTPQVAYTFDAGPNAVLIARNRKVAVQLLQGLLYYFPPKSETDMKSYVVGDNSILKEAGLDGANSVENLQPPPEIKDNIGSQDQKGEVSYFICTKPGRGPVVLPDQTQALLDPETGLPK
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Nucleus.
Sequence:
MSELSTYKGYSPKHGDKVPVLQNLNDLTPKDFYDKFIATRTPVIIKSSLPESDWKGYLWQQQDYLLSKIGDIVCKVEPIDPVSGTFGQGMSRNEMSIKEFFQKLKNGERLYLTTQYDESNEVLDGDDEVSLLVKSLCPHPTDGLLTDFSITPALMGNLVPQQCNLWIGKSENGTSSGLHHDFHDNIYAVISGYKRFVIISPDHANQLKLSGKISKIHPNGLISYEGEDCPQRSDGLTELDAAIAKTQFLEKKIGSLKELAVPQESIELLEAEYENEMDRVLQMQIGGPEEDWNDLEEGDAASLLDGSVGGDPESDILLNEGNDIEATSLQDTKPELPDHFTKVSVNGLHKFMGFDDAKNVDVDKDELSALAGTVPLVVDLEPGDMLYLPASWFHEVTSSSASSGGSDVHIAFNYWFHPPDNLEDFDHPYLDRNIWQAKRHLVGEAIDQLYATNKKNEKRPAEDDSPSQKKTCQ
The following text describes a protein:
Function:
Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTRQATKDPLLRGVSPTPSKIPVRSQKRTPFPTVTSCAVDQENQDPRRWVQKPPLNIQRPLVDSAGPRPKARHQAETSQRLVGISQPRNPLEELRPSPRGQNVGPGPPAQTEAPGTIEFVADPAALATILSGEGVKSCHLGRQPSLAKRVLVRGSQGGTTQRVQGVRASAYLAPRTPTHRLDPARASCFSRLEGPGPRGRTLCPQRLQALISPSGPSFHPSTRPSFQELRRETAGSSRTSVSQASGLLLETPVQPAFSLPKGEREVVTHSDEGGVASLGLAQRVPLRENREMSHTRDSHDSHLMPSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPMPSTPRVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPPVATPSGPHSNRTPSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVELQPLLTEISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATTSLIFSSQHPLCASPPICSLQSLRPPAGQAGLSNLAPRTLALRERLKSCLTAIHCFHEARLDDECAFYTSRAPPSGPTRVCTNPVATLLEWQDALCFIPVGSAAPQGSP
The following text describes a protein:
Function:
Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTSLMKDPFQIDFAALKKGEISMGTTITALRFQEGVILAADSRTTMGAYIANRVTDKLTQLSEKIWCCRSGSAADTQAVADILKYYLSQYRMQYGVEPTVQTAASLASEMCYQNKDYLTAGLIIAGYDEETGGEVYSIPLGGSVHRQPLAIGGSGSAFIYGFCDANFKENMDKETAIQFLKNAVGLAMERDRSSGGTIRMVILTKSGIERKFFALNTANPLPTFPIQQK
The following text describes a protein:
Function:
May participate in a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MQQIKPSNKCAKFGTNSKKIIASGDDKNCVQIWQIGESKPIATLSSQNNSNAQVEVARICFSFCEAEIFSGSNRGIINVWDVENKRLLQTLKGHSACVNALCIYPSDENKNLLFSGAYDTSIKLWDLRSKTSVNQFKGHTMQINTLAVSPNSKLLASGSNDGSVKLWDIAQGKLITSFTQHDSQITCLAFNPLDKLLASGGADRCIRIWNLQDLNQISMTRTDSTPIQSILINDNGKVIYSATHESLKVWDIEHDCQLIDNVESMWKGVQDMIITQDQEQLLGLASNPQSGFSLHGVSLKSIGQDNRLNEQKQTGNANSKQRGRTPDRRQEMVTKAQEPENKQKGKPTQQIQEQNYINQDNQLEKQKSNEVPKDYQSLQPQPMFPPIQPQNYNSPYINNPHNNNNQNGLLQYQLQQQQSQQQQQQLLYQYQIQQTIQINQQNQQQNLSSQQQKNQIVQPLNNQPQYHSNQQAQLKQQMPQNNQQEDDEYNDNFEEDPDMTTTSELTLSQFMLGDHNKEKFKQVDLIHEINKDHNRINQILSQRMKYIKPILSWWINNNIKSAINAINQVIDPSILQDALSLYSQQPKFSSIPIENFPLLLEKARILIESRFAFHIKTGLDFTYKSLCLFRDEILNIKLFNQLSKADLAREERIQKYDKVIEQLKIIAQMPKMQKLIERNKDELTELAKKLQLETAGLLKKINPNNSQN
The following text describes a protein:
Function:
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MALKIVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISTCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDVSWAAFNIVEVMSSSKFTYKRIGYLAASQCFHEGTDVIMLTTNQIRKDLSSPNQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDPDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMLHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIASQMLDVAIRVKAIRAFAVAQMATLLDNAHLLTGNTQRNGICEVLYAAAWICGEFAEHLEDPMLTLEAMLRPKVATLPGHIQAVYVQNAAKLFATVLQKHEGETDSQAAQETSQLLIDRLPLFVQSANLEVQERASCILQLVKYIQKLQQKNVEVAEEVTALFAGELNPVAPKAQKKVPIPEGLDLDAWINEPPSESESEDEKPKAVFAKEEPKHSRSRHTEVDEKELARRREARKQEQANNPFYIKASPSSQKVYDAPGVEHIPVVQIDLSVPLKVPGMPMSDQYVKLEEERRQKEKADKKKKEKKKKREKRGKGRKGDSGPESEEDITPAHHVDIVTEEMPENALPSDDDDKDPNDPHKALDIDLDNLLSGAGSRPLADSEKLPVRTHRPEVLKSPAEDRDDNTIPQETKKKSSKDKKEKKKDKEKDRKRSKEDKKKKKKHKDVEEELPESLPEEVVQSEETKEVAVPPTSADASDLDFWLSSAPVPPVAQVVTVSSSAAAATVDSSSAAAAESEPEELKDTEPDDTKSSKHKKKKQKKEKEEKEKKKKKRHHHHHHHHSDAGAEDSVQNGTVEDEEPLPPMSNYSLLAENSYIKMMKEDADQVCDIQGNHQDESKVVVSVIFENKSDSFLKSMEFNVLDSLNSKLQRPDGAGPHDGLTVPFQLPPGVSNEARFVFSVQSIVMPQKLKGTLTFIVKTDESSTHEKLDFKLHFTCTSYLITTPCYSDAYAKLLESGDLKGSSLRLEGVNMPFHHLLARICFHHHFSVVERIDSCASMYSRSIQGHHVCLLVKSSDQTVSIDAKCDEPSLLGNVLDEIKQTFSKC
The following text describes a protein:
Function:
Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Constitutes an essential virulence factor in gas gangrene. Binds to eukaryotic membranes where it hydrolyzes both phosphatidylcholine and sphingomyelin. The diacylglycerol produced can activate both the arachidonic acid pathway, leading to modulation of the inflammatory response cascade and thrombosis, and protein kinase C, leading to activation of eukaryotic phospholipases and further membrane damage. Acts on human and mouse erythrocytes, but not on rabbit or horse erythrocytes.
Miscellaneous:
MISCELLANEOUS: Two main forms of alpha-toxin can be purified from C.perfringens; a major form with a pI of 5.48, and a minor form with a pI of 5.6. Both are equally active. Variations seen in PLC activity between different strains may be due to transcriptional regulation; MISCELLANEOUS: Mutating residues 303 or 359 of the C.perfringens toxin to match those found in C.bifermentans (301 and 358 respectively) reduces toxicity considerably.
Subcellular Localization:
Secreted.
Domain:
The protein is composed of 2 domains; the N-terminal domain contains the phospholipase C active site (PLC), in a cleft which is also occupied by the 3 zinc ions. The C-terminal domain is a putative phospholipid-recognition domain, which shows structural homology with phospholipid-binding C2-like domains from a range of eukaryotic proteins. The ability to bind membrane phospholipids in a Ca(2+) dependent manner and toxicity is conferred by this C-terminal domain, which also contributes to the sphingomyelinase activity.
Sequence:
MKRKICKALICAALATSLWAGASTKVYAWDGKIDGTGTHAMIVTQGVSILENDLSKNEPESVRKNLEILKENMHELQLGSTYPDYDKNAYDLYQDHFWDPDTDNNFSKDNSWYLAYSIPDTGESQIRKFSALARYEWQRGNYKQATFYLGEAMHYFGDIDTPYHPANVTAVDSAGHVKFETFAEERKEQYKINTAGCKTNEAFYTDILKNKDFNAWSKEYARGFAKTGKSIYYSHASMSHSWDDWDYAAKVTLANSQKGTAGYIYRFLHDVSEGNDPSVGKNVKELVAYISTSGEKDAGTDDYMYFGIKTKDGKTQEWEMDNPGNDFMTGSKDTYTFKLKDENLKIDDIQNMWIRKRKYTAFSDAYKPENIKIIANGKVVVDKDINEWISGNSTYNIK