lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols. Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis.
Subcellular Localization:
Secreted.
Sequence:
MKVTALCLLCLLHLGFAAAEERIFYIGIRETNWDYAPSGNNIISGTSIKDDEDAQTFLVGGPDRIGRVYKKAVYLQYSDDSYSKEIKKPQWLGHLGPILKAEIGDIIIVHLKNFASRPYSIHPHGVQYTKENEGALYPDNASSGHKDDAIEPGQSYTYRWEAVSEQGPTVQDEDCITRIYHSHIDGPKDVSSGLIGPLIICKKGSINAVEQHKYKEFVLMFSVIDENLSWYLDENINTFCTEPSSVDKNDTDFQESNKMHSINGYMFGNLPGLSMCEGEHIHWYLFGMGNEADIHSAYFHGQVLTFQMYRVDTLSLFPATMIEGHMVTKNPGKWLLTCQVNDHLAGGMQAIYEVKSCPAQAQERESSRIGRERRYFIAAEEAMWNYAPTDTNQFTGQKIDHPDTESAIFFQRNEVRIGGTYTKAVYVEYTDATFTTRKQRSKDEEHLGILGPVMIAQVGDSMKVTFKNKASRPYSIQAHGVSYSKNMEGASYRTGNLTNDDPSPGSHVAPGDTFTYEWEVSSAVGSTNQNLNCLVWLYFSSVDAIKDTNSGLVGPLLICKSIDANNHQRGIAHNYFLLPTVFDENESWYLDENIQQFTGTPANVNKEDPDFQESNMMHSINGYMYGNQPGLDMCAGDTVLWHLMGLGNEVDMHGIHFSGNTIVTHYTRADTASLFPHISYSVMMNPDNEGVFNVECMTTDHYTAGMRQHYRVKSCGKQSFSLLFRTNTYYIAAEEIEWDYSPNRTWEHERHIHHGESPGDAFLNKGEKFIGSTYKKAVYRQYTDRTFTKRKERNEEEKHLGILGPLLIARTHEKVKIVFKNMASRPYSIYAHGVKTDGPVVQTEPGQTQTYIWKIPERSGPGYHEDVNCVTWAYYSTVDQVKDTYSGLIGPLVICKRSLLPLDMLSKPKRFALLFLIFDENESWYLDENIKTYSLHPDQVQKEDEDFIESNKMHGINGKLYANLEGLTMHVGDKIYWHLIGLGNEADIHTMHIHAHSFTYVRGATFHSDVYDLFPGTFKTVEMIARVPGTWLLHCHVTDHIHAGMEVLYTVLEKKQSQSIFTKFIKQ
The following text describes a protein:
Function:
Catalyzes the phosphorylation of adenosine to adenosine monophosphate (AMP). Can also catalyze the phosphorylation of the adenosine analog 2-methyladenosine (methyl-Ado) to methyl-AMP, the first step in the metabolism of this compound to an active form that displays antitubercular activity. Is not active on guanosine, inosine, deoxyadenosine, cytidine, uridine, or thymidine. Prefers dGTP and GTP to ATP as phosphate donors in vitro.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MTIAVTGSIATDHLMRFPGRFSEQLLPEHLHKVSLSFLVDDLVMHRGGVAGNMAFAIGVLGGEVALVGAAGADFADYRDWLKARGVNCDHVLISETAHTARFTCTTDVDMAQIASFYPGAMSEARNIKLADVVSAIGKPELVIIGANDPEAMFLHTEECRKLGLAFAADPSQQLARLSGEEIRRLVNGAAYLFTNDYEWDLLLSKTGWSEADVMAQIDLRVTTLGPKGVDLVEPDGTTIHVGVVPETSQTDPTGVGDAFRAGFLTGRSAGLGLERSAQLGSLVAVLVLESTGTQEWQWDYEAAASRLAGAYGEHAAAEIVAVLA
The following text describes a protein:
Function:
Seed storage protein.
Sequence:
MAFVSLLTILLAISSSSVALTEPVASMADQGVFPEQHGRGHHGVFPEEHGRGHHRGGREEEREENPYVFHSDRFRIRASSEAGEIRALPNFGEVSELLEGISRYRVTCIEMKPNTVMLPHYIDAKWILYVTGGRGYIAYVQQNELVKRKLEEGDVFGVPSGHTFYLVNNDDHNSLRIASLLRTESTMRGEYEPFYVAGGRNPETVYSAFSDDVLEAAFNTDVQKLEHIFGAHRRGVIFYANEEQIREMMRRGGFSAESTSASEQPKPFNLRNQKPDFENDNGRFTRAGPKDNPFLDSVDVTVGFGVLNPGTMTAPSHNTKATSIAIVMEGEGRIEMACPHLGQEHGWSSPRERGHQDINYERVRARLRTGTVYVVPAGHPITEIASTNGRLEILWFDINTSGNEREFLAGKNNVLQTLEKEVRHLSFNIPRGEEIEEVLQAQKDQVILRGPQRQRRDEPRSSS
The following text describes a protein:
Function:
Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.
Sequence:
MKIIVTDEVAQEGLALLAQDPRVELDVKLGLKKEELLAIIGDYDVIITRSGTTVNRELLDAGKKLRLVARAGVGIDNVDVDYASSRGVIVVNAPFGNTNSAAEHAMALLLSFCRNVTRANGSLKSGEWKRAPFTGYELKGKTAGVIGLGKVGGRVATRLKAFECDVLACDPYIAVKRAHDLGVKLVSHDEIYKNCDIITVHTPLTDETRNMIGERELAMMKDGVIIVNAARGGIIEEAALLKYLESGKVAGAAVDVFSEEPPKSEYLKKLIGHERVVVTPHLGANTFEAQVNVAVDVSREILNYLDDQPLENAVNIPRFDLALMDQMRPFLNLMNTLCEFGIQLLDANISKIVFGFSGSIAHYDCTPLTVCGLASILNRMVDQDVNMVNASLIAEGMGIVVEESKTTHADAFSNLITIVVEGEGGKRRTISGTLFEGLPRIVRLRDYSMDFAPEEHMLLLHYADRPGMIGKIGTIMGQHEINIASMNLGRSEKKGEAMVILSLDSAVPPQVLEEVRAATDATFIKAIHMPGARCSRSCGCTA
The following text describes a protein:
Function:
Catalyzes the N-acetylation of the amino acid thialysine (S-(2-aminoethyl)-L-cysteine), a L-lysine analog with the 4-methylene group substituted with a sulfur. Substrate specificity: thialysine > O-(2-aminoethyl)-L-serine > S-(2-aminoethyl)-D,L-homocysteine. Does not act on polyamines, such as spermidine and spermine, nor on diamines putrescine and cadaverine.
Sequence:
MKNFEIVTVTPDHAEQLISMIHELAEFEKMKSSVVNTAEKLRKDIENKAVHGFIAFIGEEPAGMNLFYYAYSTWVGQYLHMEDLYIRPQFRRMGLARTLWKKLAELARDKGIVRLEWAVLDWNKNAIALYDTVDYVNLTKSEGWFTFRMDGAAINKFADE
The following text describes a protein:
Function:
Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAAPRDAEIHKDVQNYYGNVLKTSADLQTNACVTPAKGVPEYIRKSLQNVHEEVISRYYGCGLVVPEHLENCRILDLGSGSGRDCYVLSQLVGQKGHITGIDMTKVQVEVAKAYLEYHTEKFGFQTPNVTFLHGQIEMLAEAGIQKESYDIVISNCVINLVPDKQKVLREVYQVLKYGGELYFSDVYASLEVSEDIKSHKVLWGECLGGALYWKDLAVIAKKIGFCPPRLVTANIITVGNKELERVLGDCRFVSATFRLFKLPKTEPAGRCQVVYNGGIMGHEKELIFDANFTFKEGEAVEVDEETAAILRNSRFAHDFLFTPVEASLLAPQTKVIIRDPFKLAEESDKMKPRCAPEGTGGCCGKRKSC
The following text describes a protein:
Function:
Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C7 serves as a membrane anchor. During MAC assembly, associates with C5b and C6 to form the C5b-7 complex, a key lipophilic precursor of the MAC complex, which associates with the outer leaflet and reduces the energy for membrane bending.
Subcellular Localization:
Secreted. Target cell membrane; Multi-pass membrane protein.
Sequence:
MWGSYGSWSECDPCTKLQTRSRAMVVYAQFGGNPCSGMRSESRPCETTQGCPLDDGCRDRFRCRSGKCISKSLVCNGDQDCEEDGLDENGCTNRNFVTCEHTMTPPNVNLVGLGFDVVTGKRRGSVINTRSFGGQCRTIFSGVHKNFYRLPLSTIQYNFLVKVQNDFSDEMFSSKWHYAKDVVNRETVTGTTKGYSNYDFHETHDTSQYHRLLVLKNDIEVVQFQSNSPQYIPIAEEFWKALAKLPSVYDYTAYRKVLERFGTHYVSQGTLGGFLKIIMSIDSESEKYLAVESKKFHECEKKVRFILIFPLIITKCKKGDKTTITPRGYSTNNVVAKVDVEGGGLSHSAALQRMQLDDASKNWEMYSNWADSIRSFPKIIKQKLRPLSELVKDVQCAGVKKLYLRRAIEQYRAENDPCHCQPCRNNGIAVMDGDECKCICKPGTSGVACEQGTEVEGQQGVIHGSWTCWSAWSTCSRGQRSRSRRCQNPAPQNGGQHCIGDTVEMSSCDEEDLEYLKTMEPQCFDNTLPPSQKCETPPALINGFIMNPKDVYLVGGRVEYSCIAGFHVLGNSILECSVDQTWSPSLGQCTASSCKLKFLNEEVLASPLKPSYDIDPAEITCSQEETPPSPITPTVSCEAWEKPSRDKCICRIPHECSPSLDICGTLPGSGKLIPMTVCKMHALKCNKKNFEIAEYSDCVWPQRNTLNCSSCHMWEKCDDTTSSCRCKELAECLNSGINVCVRVGEDDTASTQTMSECEAGVRRCNGEKVSVVSILPCAS
The following text describes a protein:
Function:
Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Miscellaneous:
MISCELLANEOUS: Present with 3060 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSVSEQDPNRAYRETQSQIYKLQETLLNSARTKNKQEEGQESNTHSFPEQYMHYQNGRNSAYDLPNVSSQSVLAFTEKHYPNKLKNLGTLYYNRFKEGSFDEDSTSYSDRHSFPYNLYDNTLPPPFLPAIGIQNINNIATLKITYEDIQASFNNIESPRKRNNEIWGCDIYSDDSDPILVLRHCGFKIGAPSGGSFHKLRRTPVNVTNQDNVTGNLPLLEGTPFDLEVELLFLPTLQKYPSVKRFDITSREWGSEATVIHDGLSYGIYSIVIKQRLDRDKPHEPNGYIKNLKWT
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MSTDQVDVSFKVLSLLSKERAVYGLRNGDHERYRRHCSNKVHRLRQVTGTTCGKKTYKAPSKIEVESVKDVRQLQLLLFLAERALAHSHELKKNKNHSKKDQLSWLRQAFKVSTQLYFLVQSLSASSSDLPGRVDAKTLGEITIYHLTIRSELSFEKSNWIESLTDLACRRKLLTTLGEGAKDSYDEALANEFIDSHDPLIRYCAYKLGRAESHDIEGVMADIEPEVLEEALPGMSQLLESLRTETGVEEMEEGRRKLEDVEFAGEKVELRNAEIVGVMVRVQDALSKLGDGKSKGARGMKRWDRVLSVLGEAEGVARKLLEDNEANGASSSLRSTRTAQSLALAHQYIIYLLLTHRIRRDLALVETLSSSPVPKDPTQFKVQGGKAKLEEAVKTLGAVVKLYGTMLQSLKQAAELSVVQEKEGVRSGVEGLEAYFHAIRCYNLARLHCIHPDPSYSSAVQLLSNASLSLRQAQDFLASPVDEPIVSVPAEDLSSLSKNISALEKASKRGLFGRSVEKPVFFDMAFNYIDLPIDELQRLAGNGEKVQVATVKTQEKEVEIKPVENMKKSRDSRETTPAVDSQEEKQEGKKGWLGGWFGRK
The following text describes a protein:
Function:
Has antibacterial activity.
Subcellular Localization:
Secreted.
Sequence:
MKFLLLVLAALGFLTQVIPASAGGSKCVSNTPGYCRTCCHWGETALFMCNASRKCCISYSFLPKPDLPQLIGNHWQSRRRNTQRKDKKQQTTVTS
The following text describes a protein:
Function:
May be involved in extracellular digestion.
Subcellular Localization:
Secreted.
Sequence:
MKQYLTTAFVALLMAAGYYNVSYENKSDFEVWATQNNKFYTESEKMYRMGIYYSNKKMIEEHNKRDDVTYKMGENQFMALTNEEFVDLYLQKSIPPMDTIELLIPKIQLEGLNAVDWKNYSSVKYQGNCHAGYAFSVSNSVEAWYGIKKYQKISPSTQQIIDCDYNSSGCDGGYNMYAMDYVRSVGLTSNQSYPYADKEQVCKQSRNGSYFISGYLFVGGYQENLQYYLSNYPVSVAVNANNWQFYNSGVFQNCTSNETNHHALAVGFDNNSNWIVQNSWGSWWGEDGHIRLKEQNTCGILNYAYQIY
The following text describes a protein:
Function:
Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1.
Subcellular Localization:
Nucleus.
Sequence:
MARHLSESGFEELKEICSKDNCETFIKEALNNDLKDIGDKCLPDNALRSKMDFIEGPLVLQVQKVKNVQVPKAIDITSSRNNSDDCLMRIVLTDGTATILAINIDRIHNFNPSIAPGSKLKLTEKVPFLQGFLLLSNNNSSVLGGRVEKLIDNWEMKQSLATLTRGNVGEDGPPPFVPFEQMKKSSSRYEGYSTRSSGEPSKKNAVDAFGMQRKANIEAVMADRSAKKNPQDNSDEKLASIVDMGFSLENAIQALSVSKGDVQKAVNHLVANQVEDNNNNNNKNNNNNYNKNNKNKMDSNSKNKSGRDDYSGKKNYDYSKFNNSNNNNNNNNNNTRYNNNNNNNNKNKDNYDYNERSNDDNRYKNDRNNFNRKSSYEKNNNNTSNSEDNGRQQQQQQQQQQHQQQHQQTSRNYQQKNQSENRFSRPLLDRVVDSNKTTTTTKEAVVITPSTLVATTTTLVATTTTSSSPYSVATTSSSAAATTTSSSEATKLSSSVATSSAATTAATTATKASPHYNKTYNNSSSNNKYQSSPRNEIKYYVPRKAEKSSASLSSSQPPPPSSTSQPTPSSLSSSQPSPSSSSSSSLSTLKSRNKYPESKNASSCYIQNKSSDYNKRNKNINNNNNNVDSSGENVSDSKATTNVITKDESANNKRHDRQRPHFQQQQLPHFQLQNQFQQQQQQQLSLPQHQQRLQHQQQPQINQQQQPQINQQQPQISQQQQMFSEVHINDYKSMKPGDVCMSKWKDGKFYRAQIISCSPIMLVNYLDYGEVDQVYGGIMPLPGYKPPSHNY
The following text describes a protein:
Function:
Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.
Subcellular Localization:
Nucleus.
Sequence:
MDNAIGNSARSEEEEMEVAATPSVVSAPEATRSSFGENDGMSSEDDEGIVEQLSGGEAEEHMINLTDLNPYILCSICKGYLIDATTITECLHTFCKSCIVKHFYYTNRCPKCNIVVHQTQPLYNIRLDRQLQDIVFKLVVNLEQREKTQMHAFYKERGLDVPKPNIPQPIPSSRAKPKKMLGPVFRIPPELDVSLLLEFMGAEKGTGNFKPLEKKYVRVSGEATVGHVEKFLRRKMELNATCQVDIICGDHLLEHFQTLREILGAIGEKAVQCFFHPLGQRHTLRFGEIRCLATNLLLWQDGTRSTSFSKVAGYVPYVDWQTTGDSVRQYTWFMQLKLASAYGIQQKKSPCFEATESNIQGVTGWGTLLYNLDSLL
The following text describes a protein:
Function:
Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Domain:
The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
Sequence:
MAPACQILRWALALGLGLMFEVTHAFRSQDEFLSSLESYEIAFPTRVDHNGALLAFSPPPPRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSRLLAGHVSVEYWTREGLAWQRAARPHCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVYKRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLRQGPDQVQSLEALGPINASLIVMVLARTELPALRYRFNAPIARDSLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAKCDSPTPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTCHGH
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the first two steps in lysine degradation.
Subcellular Localization:
Mitochondrion.
Sequence:
MSLQSPGFKMLRAHRTKLDRLVRSFSKGLHHKAVMALRREDVNAWERRAPLAPRHIKGITQLGYKVLIQPSNRRAIHDKDYVKAGGILQEDISEACLILGVKRPPEEKLMSKKTYAFFSHTIKAQEANMSLLDEILKQEIRLIDYEKMVDHRGLRVVAFGQWAGVAGMINILHGMGLRLLALGHHTPFMHIGMAHNYRNSSQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQDIFNELPCEYVEPHELKEVCQTGDLRKVYGTVLSRHHHLVRKTDGVYDPVEYDKYPERYMSRFSTDIAPYTTCLINGIYWEQNTPRLLTRQDAQSLLAPGKFSDAGVEGCPALPHRLVAICDISADTGGSIEFMTECTTIEHPFCMYDADQHIIHDSVEGSGILMCSIDNLPAELPIEATEYFGDMLYPYVEEMILSDATQPLESQNFSPVVRDAVITSNGTLPDKYKYIQKLRESRERTQTLSGTKKKVLVLGTGYISEPVLEYLSRDDNIEITVGSDMKNQIEQLGKKYNINPVSVDIGKQEEKLGSLVATQDLVISLLPYVLHPLVAKACITNKVNMITASYITPALKELEKSVSDAGITVIGELGLDPGLDHMLAMETIDKAKEVGATIESYVSYCGGLPAPEHSDNPLRYKFSWSPVGVLMNIMQPATYLLNGKVVNVAGGGSFLDVVTPMDYFPGLNLEGYPNRDSTKYAEIYGIPSAHTLLRGTLRYKGYAKALNGFVKLGLLNRDTFPALRPEANPVTWKELLCDLVGISPSSKHDVLKEAVFKKLGDDTQLEAAEWLGLLGDEQVPQAESVVDALSKHLAMKLSYGPGEKDMIVMRDSFGIRHSSGHLESKTIDLVVYGDVNGFSAMAKTVGLPTAMAAKMLLDGEIQAKGLMGPFSKEIYGPILERIKAEGIVYTTRSTIKP
The following text describes a protein:
Function:
Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Peroxisome membrane.
Sequence:
MLVELSVKQKFLTLCGITAAAMAASLAIGQRLIPQSILTGVVFYLISGERPSTVYASIVSLPRDIRTAIIFLKLNLCLYRYERAGATVVQIFERVVARQPNKVAFLMDDGQLTFAQVKQLADRVAAHFYAKGFRKGDTIALLMETRLEYPCIWLGLSKVGIVTALINSNLRKETLRHSITVANSKAIIVSTELAGAIAEINEQEGIKGLPVHLFRSDGAPDTASSSSSSSDPLPDAEDLRLSLDSSGSSSSNVDLSAIPNDISPKDKLVYIYTSGTTGMPKAAVITNLRYTFMALGCYYMLSFRDDDIIYNSLPLYHSAGGMIGVGSVLLCGVTAALRKKFSASNFWTDCIRYKCTVAQYIGEICRFVLMTPPKPTDTQHSVRLMFGNGLRPQIWPQFVSRFNIQQIGEFYGSTEGNSNLLNIDNTMGAVGFVPNFAKAIYPVTLIRCDEETGEIIRGSDGFCIKCKAGEPGVFVGKINPKKALNSFVGYADKAASEKKVLHDVFRKGDIFFNSGDILVQDLLGNYYFKDRTGDTFRWRGENVATSEVEGVITTIVGLKDCAVYGVDIPETEGKAGMAAIVDPEGKVDLEQLAAGIRASLPAYARPLFIRVLSEVPMTTTFKLKKRDLQVDGYDLGKIQDPIYFLQSNGTYRRFTADDHETIKSGKARL
The following text describes a protein:
Function:
Bacteriocin with antibacterial activity against the Gram-positive Listeria, Enterococcus, Propionibacterium, Staphylococcus and some strains of Clostridium, Lactobacillus and Pediococcus. Lacks antibacterial activity against Gram-negative bacteria.
Subcellular Localization:
Secreted.
Sequence:
MKKKVLKHCVILGILGTCLAGIGTGIKVDAATYYGNGLYCNKEKCWVDWNQAKGEIGKIIVNGWVNHGPWAPRR
The following text describes a protein:
Function:
Required for chromosome condensation and partitioning.
Subcellular Localization:
Cytoplasm.
Domain:
Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
Sequence:
MRLKKLYLKGFKSFGRPSLIGFSDRVTAIVGPNGSGKSNIIDAIKWVFGEQSKKELRASEKFDMIFAGSENLPPAGSAYVELVFEENGEEITVARELKRTGENTYYLNGSPVRLKDIRDRFAGTGLGVDFYSIVGQGQIDRIVNASPEELRLLLEEAAGVSIYREKKKETELNLERTKANLDRVKDVLFERERQMKSLYLKAKRAERFKEYTAQLEELQKIYYGNVLKRERKKLEFYQEEEKKTNEKIKNIQKELVELETKWSTLRSEFGEMDQEIERYTKLLEDYKKRQNDLVEMKGFYSSKLADSENKYVELSTRLDELEKRREEYKKRLEEMEYIFKGVMGDYERKAKELEKFEKEKENLLSRFNDKEKEFLRVRDEISKLEKQILKLENELLRIGETLEDLEKRRKITENQILTRRRELEDKKNEFKEISRRVEELDEEEKKLTEELNAVRERLEEIEGEIRRVNLEIDAKEKRLREIQFEKEMIERDMREYRGFSRAVRAVFEEKERFPGLVDVVSNLIEVDEKYSLAVSVLLGGTAQNIVVRNVDTAKAIVEFLKQNEAGRVTILPLDLIDGSFNRISGLENERGFVGYAVDLVKFPSDLEVLGGFLFGNSVVVETLDDAIRMKKKYRLNTRIATLDGELISGRGAITGGREERSSNVFERRIKLKHLEQEMEETERQIAEKRDELASLKTEQENLKNQEALVQRELFELSRKSSSTKTVLSEILRSINQLQEEVENLEKLLVEYRAKEEGLNARREKIFEEIDELKQNRENLQRSLTEYSEELEKEKKILDELNEKIFTLRAEVGNLLETKDRYEKEMRDTGKMIERIARETEDIKLQMTSLEEEMENYRKFIREHEREIEHLKKEMDSVFEAMKLHRSGKEEKMRELQEVENRMDELKEEKERLRNHLHQIDLALQETRLKIANLLEEFSGNEEDVEELDEEKLEEIYRQIKDLENKIKYLGPVDLTAIDEYEKLREEYEEILKQKEDLEEAKRKLEEIIEKTDREAESLLFDVYQRVNESFNRFISLLFFGGEGRLNIVSEAKSILDAGFEISIRKPGRRDQKLSLLSGGEKALVGLALLFALMEIKPSPFYVLDEVDSPLDDYNAERFKRLLKENSKHTQFIVITHNKIVMEAADLLHGVTMVNGVSAIVPVEVEKILEV
The following text describes a protein:
Function:
Transcriptional activator involved in cell elongation. Regulates the expression of a subset of genes involved in cell expansion by binding to the G-box motif. Binds to chromatin DNA of the FT gene and promotes its expression, and thus triggers flowering in response to blue light.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing BHLH74 show increased hypocotyl and cotyledon lengths.
Subcellular Localization:
Nucleus.
Sequence:
MGGESNEGGEMGFKHGDDESGGISRVGITSMPLYAKADPFFSSADWDPVVNAAAAGFSSSHYHPSMAMDNPGMSCFSHYQPGSVSGFAADMPASLLPFGDCGGGQIGHFLGSDKKGERLIRAGESSHEDHHQVSDDAVLGASPVGKRRLPEAESQWNKKAVEEFQEDPQRGNDQSQKKHKNDQSKETVNKESSQSEEAPKENYIHMRARRGQATNSHSLAERVRREKISERMRLLQELVPGCNKITGKAVMLDEIINYVQSLQQQVEFLSMKLATVNPEINIDIDRILAKDLLQSRDRNTPTLGLNPFAGFQGNIPNLSATTNPQYNPLPQTTLESELQNLYQMGFVSNPSTMSSFSPNGRLKPEL
The following text describes a protein:
Function:
Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
Sequence:
MDVMDMVNKSDNTSAVIVKTKILGLKEELDKCKEMCQSSKEELNKERSKKSQTEIEVLALREKVKSMEDQCTEINNKVQEATDKLMGVTKSRRALDHRKNMDLDRMATLEEMYKETKMLLVESERKYEEVSKKLLIVKADSDRAEARIQRAEITTKNIKDETKGLTAKLKSYQLQLEEASMHNEKVADQIHKLQTDIKYLHKTNIPLMFDFI
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex. Plays a role in DNA damage response (DDR) signaling during the S phase.
Subcellular Localization:
Nucleus. Chromosome. Cytoplasm. Note=Localizes to sites of DNA damage in a H2AX-independent manner.
Sequence:
MASNSTKSFLADAGYGEQELDANSALMELDKGLRSGKLGEQCEAVVRFPRLFQKYPFPILINSAFLKLADVFRVGNNFLRLCVLKVTQQSEKHLEKILNVDEFVKRIFSVIHSNDPVARAITLRMLGSLASIIPERKNAHHSIRQSLDSHDNVEVEAAVFAAANFSAQSKDFAVGICNKISEMIQGLATPVDLKLKLIPILQHMHHDAILASSARQLLQQLVTAYPSTRMVIVSLHTFTLLAASSLVDTPKQIQLLLQYLKNDPRKAVKRLAIQDLKLLANKTPHTWSRENIQALCECALQTPYDSLKLGMLSVLATLSGTIAVKHYFSIASGNVGSSPRSSDLVKLAQECCYHNNRGIAAHGVRVLTNITVSCQEKDLLALEQDAVFGLESLLVLCSQDDSPGAQATLKIALNCMVKLAKGRPHLSQSVVETLLTQLHSAQDTARILMCHCLAAIAMQLPVLGDGMLGDLVELYKVIGRSATDKQQELLVSLATVIFVASQKALSAEVKAVIKQQLESVSNGWTVYRIARQASRMGNHDMARELYQTLLTQVASEHFYFWLNSLKEFSHAEQCLTGLQEENYSSALSCIAESLKFYHKGIASLTAASTPLNPLSFQCEFVKLRIDLLQAFSQLICTCNSLKTSPPPAIATTIAMTLGNDLQRCGRISNQMKLSMEEFRSLASRYGDLYQASFDADSATLRNVELQQQSCLLISHAIEALILDPESASFQEYGSTGAAHADSEYERRMMSVYNHVLEEVESLNRKYTPVSYMHTACLCNAIISLLKVPLSFQRYFFQKLQSTSIKLALSPSPRNPAEPIAVQNNQQLALKVEGVVQHGSKPGLFRRIQSVCLNVSSTLQSKSGQDYKIPIDNMTNEMEQRVEPHNDYFSTQFLLNFAILGTHNITVESSVKDANGIVWKTGPRTTIFVKSLEDPYSQQIRLQQQQAQQPLQQQQQRNAYTRF
The following text describes a protein:
Function:
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Subcellular Localization:
Mitochondrion.
Sequence:
MIILKHILYKNNGRRFFEKTIPNKIYNFYLSGLCKFSSCCIDNLRNIGISAHIDAGKTTLTERILYYTGKIKSIHEVRGNDGVGATMDSMELEREKGITIQSATTNCVWEINNKKYNINIIDTPGHVDFTIEVERSLRVLDSAILVICGVSGVQSQTLTVNRQMDRYHIPRILFINKLDRDGANVERTLHTIEKRLNLNTILLQMPIGIEQKFKGVYDLINRKGYLFQGKNGIILNEINNKEEILSLDNSFSFEIMELLRNRILEKLADVDDEFAEIYLNNDINDIKKNDIYSSIRKSTIKNLVTPICLGSAKNNVGVQILLNYVCNFLPSPKEINNYGYIIYSDVLEDKIKNNDICNETQNTQQYQSQDQNDISIINYNNQNSINNYTHKDDHHSSKNKSKKKIQLLCDNNLPMVGFLFKIQEDNMYGQMSYFRIYQGKIKKKEMITNMMTNKKEIVKKIMKMHSNMAKEVNEASAGDIVAICGINGSTGTTYTNGINTNLHLLNIFIPKPVISVAVEILKKGDMTKLTKALNKFTKEDPTFYVKTDEQTKETIFEGIGELQLEIYKERLKREFNINVNLKNPKINFKETITKPFECSYTYKKQKGGAGLYAHVHAIFETISDNYNDTTHCTFVNEVIGNDLPKNFILSIEKAFKEQIEKGYLYNSEIINMKMRLIGGKIHEVDSNDLAFKKATINLIKENYHNFCPVLLEPIMLVEIISNYEHQSNILTSITKRKGLVNNIVNNLNIIYIYADIPLKHMFNYINEIRAITQGQGTYTMEFSRYEQVSKNDLDEILKQKSTA
The following text describes a protein:
Function:
[CLE16p]: Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Regulates the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem; this signaling pathway requires CRN and CLV2.
Subcellular Localization:
[CLE16p]: Secreted, extracellular space.
Sequence:
MEACSRKRRRRRAYTTSTTGYAAVFFCGIFVFAQFGISSSALFAPDHYPSLPRKAGHFHEMASFQAPKATVSFTGQRREEENRDEVYKDDKRLVHTGPNPLHN