lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Cell membrane. Note=Colocalizes with SERT at the plasma membrane.
Sequence:
MKPAMETAAEENTEQSQERKVNSRAEMEIGRYHWMYPGSKNHQYRPVPNLGDRAGPLSSPGCFECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALAGTVAILEQHFSTNTSDHALLSEVIQLMQYVIYGIASFFFLYGIILLAEGFYTTSAVKELHGEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQSNGTSGVEQICVDVRQYGIIPWNAFPGKICGSALENICNTNEFYMSYHLFIVACAGAGATVIALIHFLMILSSNWAYLKDASKMQAYQDIKAKEEQELQDIQSRSKEQLNSYT
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system involved in the uptake of lactate. This protein specifically binds L-lactate.
Subcellular Localization:
Periplasm.
Sequence:
MKRVSRRAFLRRLGVGVAATAAFSPLAVAQARRYRWRIQTAWDAGTVGYSLFQKFTERVKELTDGQLEVQPFPAGAVVGTFDMFDAVKTGVLDGMNPFTLYWAGRMPVTAFLSSYALGLDRPDQWETWFYSLGGLDIARRAFAEQGLFYVGPVQHDLNIIHSKKPIRRFEDFKGVKLRVPGGMIAEVFAAAGASTVLLPGGEVYPALERGVIDAADFVGPAVNYNLGFHQVAKYIIMGPPETPAIHQPVDLMDFTINLNRWRSLPKPLQERFIAAVHEYSWIHYAGIQKANLEAWPKYRQAGVEVIRLSNEDVRKFRRLAIPIWFKWAKMDKYSREAFASQLEYMKGIGYVTDEELKGLSL
The following text describes a protein:
Function:
May be required for DNA interstrand cross-link repair.
Subcellular Localization:
Nucleus.
Sequence:
MSEDVLLEEDIWEYKSIRKRKPQSNPDSTSVSMQTVTKGKCRPKRKGSGNRKKSVEKNSTPQKSEQRLRPSEDLDPCKDDSSVYAQESVSSLTEQGSPSTRPVCDGYCPSCQMPFSLLVVQTPRWHVAECLDTPGSVEKECPDGLLCTSTIPSHYKRYSHFLLAASRAGEYLVNSTANTVERKMTCSTAAKSSCFPSPVEDSQAEKPSKNLKNVPNNECTSKIKDSEQRKSLNITSESTSSFADVQKPQQVFQLTQTTDNSCKFEFYDFTSSQESVSEDLCSQKDTSQPSLLQSKADFSDWEISYSPLSTCEESEGEAEEEKEVKTSQNKLLKVQNFEGPESNTEVFKFKKQHCEEINTSSCLYHSEKSASQSHVDSKCSNSPCVDNQQEMLSAESSFPLNCNQEFQQPGLLSPAINTGNKESQDKGACVLDSVYSCLTRTQSLLLTEGGRSPLSQKNKVLRAPSVVLTNTDKMTADATEKGTCQESLQPAVKKEENLDSTGVCFPSPISKTVSSHSLASMNAKSSPAKELKQMDIGVFFGLKPKVKEESKGEACLSEGKQIPSSVAPSGKRPRQQKRKAEGSVEDLEAVEESSNKDGGDANVTSGGQRKWRKRFRESSTTDEGARKKQCPFYKKIPGTGFTVDAFQYGEIEGCTAYFLTHFHSDHYCGLTKNFVFPLYCNKITGNLVKSKLRVKEQYINVLPMDTECIVNGIKVLLLDANHCPGATMILFYLPSGTAILHTGDFRADPSMERYPALIGQKIHTLYLDTTYCSPEYTFPSQQEVIQFAVNTAFEMVTLNPRTLVVCGTYSIGKEKVFLAIAEVLGSKASMSRDKYKTLQCLESAAVNSLITMNWDGTLLHILPMMQINFKGLQDHLNKFSENFDQVLAFKPTGWTYSDSCLSVMDIKPQTRGNITIYGIPYSEHSSYLEMKRFVQWLKPQKIIPTVNVGDWRARSLMEKHFRDWMIEGSGHK
The following text describes a protein:
Function:
Participates in the sulfur mobilization (SUF) pathway for iron-sulfur (Fe-S) cluster biogenesis. As part of a complex consisting of SufB-SufC(2)-SufD, involved in assembly of [4Fe-4S] clusters. Exhibits ATPase activity.
Sequence:
MIKLKNFLNIYNLNYKYQYKNKINLYLIRQGLNINLIKNLSSNIFLYMFIYNFKKYSLKLLNIFKLPDWNFFDCPNINYDNIIYYSSILKDNNLIYYLKNNLNIEFLDSILIKNNSIDIIFDSMSILHTTQYFLKKLGIIFLPLFDIIFKYPLLIKKYLGTIISYKDNFFANINSIIFSEGSFCYIPKYVKCNFNLSTYFKTNSSDFAQFERTLIIVGKYSYVSYLEGCTASLYKESQLHVAIVEIIVKDYGYIKYYTLQNWYRGDYLGNGGLYNFTTKRGICLNYSKLDWIQVEVGSIITWKYPSTILKGKFSISNFYSISFISNMQIADTGSKMYHIGSYTKSYIISKSISLNNSLNIFRGLVYIKPFSYKSYNYTECSSLIFGNNSLTVTIPYIKNYNNTSYVKQEAFVSKIEIIYLFLLMQRGLSISESISLLIIGFCSDIYNKLPFEFNLEIPILFSLKIKDIFN
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Also plays a role in primitive hematopoiesis, possibly by affecting the expression of genes critical for hematopoiesis (By similarity). Plays a role in cytokinesis during early development.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Domain:
The KA1 domain mediates binding to phospholipids and targeting to membranes.
Sequence:
MAVDDYEELLKYYELHETVGTGGFAKVKLASHLITGEKVAIKIMDKESLGDDLPRVKTEIDAMKNLSHQHVCRLYHVIETPKKIFMVLEYCPGGELFDYIIAKDRLTEEEARVFFRQIVSAVAYIHSQGYAHRDLKPENLLIDEDQNLKLIDFGLCAKPKGGLDYHLMTCCGSPAYAAPELIQGKAYIGSEADIWSMGVLMYALMCGYLPFDDDNVMVLYKKIMRGKYEIPKWLSPGSVLLLSQMMQVDPKKRITVKHLLNHPWLMHGYSCPVEWQSKYPLGYIDEDCVTELSVFYKYSRTSTTRLISEWSYDHITASYLLLHSKKSHGKAVRLKHPLAVGDQAVTSFKELRPKSKLDFEEPNGEIAYVFGSMDFSDEELFSEDFTYSSFEPHTPKEYVKGRLEFNSVDSAPATPVVQRNARHKNEDKENSNTAVARDENVFLHPAPWTPTPRRKQNEKKGILTTPNKNTQTKEKNQSKETPTKKPIGTGEEFANVISPERRCRSVELDLNQAHIDSAQKKKGAKVFGSLERGLDKMITMLTPSKRKGYTREGPRKLRAHYNVTTTNIVNPEQLLNQIVRVLPSKNVDYVQKGYTLKCKTQSDFGKVTMQFELEVCQLSKSEVVGIRRQRLKGDAWVYKRLVEDILSSCKV
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Sequence:
MPERLAETLLDLWTPLIILWITLPSFVYMAPMNQAHVLTTGSPLELSRQSEEMRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDWETNKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGVIRLRKPLDFETKKSYTLKVEAANIHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNISIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHFFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIVISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEPYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELYSVGESDKET
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MADQEDVITGLHLSIGASDDELDDELMENEPENLHEGQRERTETTLFRPRRRWWLRQIQTEPRSQPTNNNTEETMEPTADAGDQRVAAAAGGGGGNIINDKTCNVTNGADDGGNGSGESGDDTSLFECSICMEMAKDPVVTCCGHLFCWPCLYLWLHVYSNENECPVCKGEVQDADVIPVYGHGNSSGSEDQTTGKASESGVRIPPRPHGHRFESARQRSDGEISTFEIQQVFRGIGHGSHHMEWHQHHFSAAGSISITTSPPVSSPLRVLTTVALRREGLLGGEYEYPRQNYVDQVSMELQQSAAAAATSVEAETRRRLLQIQQLLRAQAQRAASRTYFPSVINSSAESIVQGYLISRSMRENYSQPPDLARSQPQPSHDHDEPPLYFTQSSSAADDTQSGSETINVGTEIIDSIRSLSDSSGADRPLASDEDRGMNRVTRRRLN
The following text describes a protein:
Function:
ATP-dependent DNA 3'-5' helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins. During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity. Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer. Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori. Subsequently, two hexamers will be created. The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
Subcellular Localization:
Host nucleus.
Sequence:
MADDSGTENEGSGCTGWFMVEAIVEHTTGTQISEDEEEEVEDSGYDMVDFIDDRHITQNSVEAQALFNRQEADAHYATVQDLKRKYLGSPYVSPISNVANAVESEISPRLDAIKLTTQPKKVKRRLFETRELTDSGYGYSEVEAATQVEKHGDPENGGDGQERDTGRDIEGEGVEHREAEAVDDSTREHADTSGILELLKCKDIRSTLHGKFKDCFGLSFVDLIRPFKSDRTTCADWVVAGFGIHHSIADAFQKLIEPLSLYAHIQWLTNAWGMVLLVLIRFKVNKSRCTVARTLGTLLNIPENHMLIEPPKIQSGVRALYWFRTGISNASTVIGEAPEWITRQTVIEHSLADSQFKLTEMVQWAYDNDICEESEIAFEYAQRGDFDSNARAFLNSNMQAKYVKDCAIMCRHYKHAEMKKMSIKQWIKYRGTKVDSVGNWKPIVQFLRHQNIEFIPFLSKLKLWLHGTPKKNCIAIVGPPDTGKSCFCMSLIKFLGGTVISYVNSCSHFWLQPLTDAKVALLDDATQPCWTYMDTYMRNLLDGNPMSIDRKHRALTLIKCPPLLVTSNIDISKEEKYKYLHSRVTTFTFPNPFPFDRNGNAVYELSDANWKCFFERLSSSLDIEDSEDEEDGSNSQAFRCVPGSVVRTL
The following text describes a protein:
Function:
The main replicative DNA helicase, it participates in initiation and elongation during chromosome replication. Travels ahead of the DNA replisome, separating dsDNA into templates for DNA synthesis. A processive ATP-dependent 5'-3' DNA helicase it has DNA-dependent ATPase activity.
Sequence:
METTPRVPPHSNDAEISVLGSVLLDNDTLAALGDTVTPEMFYREGHRKIFAAMRQLQDHREPVDLVTLSEHLRVAGELDNVGGNAYLIGLSEQVPTAAYAEHYARIVQEKHTLRQLIQASGKAMQLAYEQQLPLEDLLDKAEKMIFEVAEQKKKGEAFQAMNEVVSDTFEYITLLHANKGIPDGVSSGFRDLDEQISGLQKGSLNVLAARPSMGKTAFALSIAQNVALRGEKTVAVFSLEMPAVQLALRMLCSEARVDMNRIRSGHLNERDFERLAHAAGRLAEAPMVIDDEPDLTLNALRSKLRRIAAQHGQLGLVVIDYLQLMSGGKSSGGSDNRQQEISTISRGLKGLARELEVPIVVLSQLSRAVEQRPNHRPMLSDLRESGAIEQDADIVMFIYRDEYYNKETDQQGIAEIIIGKQRNGPVGTVKLQFHSAHVRFNDLAPEGM
The following text describes a protein:
Function:
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Sequence:
MYFLLTPSRVLHRRDSAANRQKRASDWWNLDISVVVAMALHVDHKATIIDGKAIAQTIRSEIASEVSTLIEKYGKAPGLAVVIVGHRKDSQSYVSMKRKACCEVGIKSIDIDLPEQVPEAELIAKVHELNADPNVHGILVQLPLPKHINEEKVLTEISIDKDGCIELLKRSGISIKGKRAVVVGRSNIVGLPVSLLLLKEDATVTVVHSRTEDPESMIREADIVIAAAGQPMMIKGSWIKSGAAVIDVGTNAVDDASRKSGYRLVGDVDFDQACKVAGWVTPVPGGVGPMTVAMLLKNTLDGAKRVIGQ
The following text describes a protein:
Function:
Component of minor spliceosome required for U12-type intron splicing and alternative splicing of many introns. Binds specifically to U12 snRNA, which is necessary for branch-point site recognition. Required for normal plant development.
Subcellular Localization:
Nucleus.
Sequence:
MAAHATSEPAVNLPATQFESQVTEPFGVTLLVRHLPDGIPHDIVSRLFSQYGASAVRPCSGGKLRNAAFVDFKNEAFASQAHRQLNGLRFLGKVLQVQRANKPNDNKKSRQIEESVTKGNAFSTVSTNNDSKSGQILSGEPIAPKLGIDYPFPPHLQYAYPPPDANILANITNALIAVPPLYTQVLHLMNKMNLPPPFRLALPTPPLPKAGPQQTDLEHQSSSESEMESDEDIGTSKSGRKRARHGFLVGLGMDKDVPHETVGVKPSSLTPKEIPRIRKNKHVMQIKITSKVTQDEYKEESENEDPADEPKEKDSNLKPFASLEELEKGRLPPQDILSLPMFKNYTAGNPSVVLYIKNLAKDVVIDDFYYIFGSQFESSEVAKSSLGVRLMQEGRMRGQAFLTFPSVEVAHRALNLVNGFVFKGKPMIIQFGRTPGAAKPNE
The following text describes a protein:
Function:
Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis.
Subcellular Localization:
Nucleus. Note=Localizes to kinechores during late pachytene.
Sequence:
MREKRTISNKDTNYLKFPNKLQRYSRFLSRKISNTSPEKQPKKNIKEHCLSSYHKEHSVKPKQNSGNVAAKEDKDTQHLQNNVANEEATECLTRSNLKKLQEKIFDRELNDIACDHCLCSTENRRDIKYSRLWFLFELEMSENWNENLRLSCYNKYVYSAIDESWKMENILLKEQEKHYEYFPIGQLLIPNNIDYTNKQKRKENIEDLTIEIDSIIETNHQKKRFLPQSVLIKREDEIAFDDFHLDARKVLNDLSATSENPFSSSPNTKKIKSKGKTLEVVPKKKNKKIIGALERKLHIDEN
The following text describes a protein:
Function:
Does not bind lactose, and may not bind carbohydrates.
Sequence:
MFSHRTNTFYVGICSVALHSCNFVHTVLNVGFLHSFDISLTCGHNEEKEDEKLADVALKLSARFTERQFLRNARVSGKWSEEEAPIAYFPFIPDQPFRIEIHCEHQRFRIFVDGHQLFDFYHKVKSLQAINMIRIVGSLQITKLG
The following text describes a protein:
Function:
Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation.
Sequence:
MNIENLKTKAEADISEYITKKIIELKKKTGKEVTSIQFTAREKMTGLESYDVKINLI
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MLEPQENGMIDLPDYEHVEDETFPPFPPPASPERQDGEGSGSGALVPVPPKRAVKRNISKLDAHRLISERGLPALRHVFDKAKFKGKSHEAEDLKMLIRHMEHWARRQFPKLQFEDFIDRVEYLRNKKEIQTFGENNGHGVTATELDPFLTNSSESEMFASESSRSLTDEQQQRIERNKQPALERRQEMIMLMNTPRVQTIEEVNTDEDQKEESNGLNNDILDNLCNDAPLDQSFKNVQQNATEAR
The following text describes a protein:
Function:
Part of an ABC transporter complex involved in low-affinity glycine betaine uptake. Binds glycine betaine with low affinity.
Subcellular Localization:
Periplasm.
Sequence:
MPLLKLWAGSLVMLAAVSLPLQAASPVKVGSKIDTEGALLGNIILQVLESHGVPTVNKVQLGTTPVVRGAITSGELDIYPEYTGNGAFFFKDENDAAWKNAQQGYEKVKKLDSEHNKLIWLTPAPANNTWTIAVRQDVAEKNKLTSLADLSRYLQEGGTFKLAASAEFIERADALPAFEKAYGFKLGQDQLLSLAGGDTAVTIKAAAQQTSGVNAAMAYGTDGPVAALGLQTLSDPQGVQPIYAPAPVVRESVLREYPQMAQWLQPVFASLDAKTLQQLNASIAVEGLDAKKVAADYLKQKGWTK
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MDTNSASVADARVDELWATLDTRKQGHLDLPALKKGLLDDVMKAVDTDGSGQISYQGELYSQLLRNNPLLMPVGPEFRTFVHETERELLSLFKSIDYNNDGKISKPELRAALSRAGLAVPNSNLDTFFTEVDTNNDGSISYFVAGGIAGIVSRTSTAPLDRLKVYLIAQTGAATEQAVVAAKSGNVISAVRNAWTPLATAMKELWQAGGMRSLYAGNGLNVIKVMPESAIKFGSYEASVAIFNRMQCETVSGGLHGNRLIIATAKKMWAHNGVAAYYRGLPMGIVGIFPYAALDLGTFEYLKRAVARRNAKRLGCHEQDAEPGGFMTAAIGGFSGAFGAMLHPRTYTGIVDVTRQTIAGEGWRGLFKGLTPNLLKVVPAVSITYVVYDKSKKIIGLR
The following text describes a protein:
Function:
Serine/threonine protein kinase which activates checkpoint signaling in the presence of DNA double strand breaks (DSBs) and other forms of DNA damage induced by ionizing radiation and other genotoxic stresses such as UV. Plays a role in maintaining genome stability.
Subcellular Localization:
Nucleus.
Sequence:
MSVTQLKNLKHAIAQLLEWDGTKTARKKIVDEVVLLYHALGAEALSEDNQEIYDLYDLSARIFNLAKKEIEEANQQFEKERKKGTRRSEKPVPTPLFELSIQHLKRCCQQGIDHNQVPWIAYCLKLLEFPITITEKSIENEISNVLLLSSNASQLHWAEHAHLSSLWKWIWSRVETADIGALAMRNYMELAANLLENVDYVVFEKSPIDLMAKVMGTLKKSVEMGNPKEYWCHYRKFSVVHILSYIVHRWGLEARDFILREIFELTGSLSNLISVAHKDGEQSKKCIMRLIDDLVKLAMIETVHGHRTMNEVTRGNIQKLVKTGIQESLKSAHRNFSRSSTFSISEECVRYLTRWLLAERRLEQPSAAMNESFELTGDSSSKKKDDATFDSLIDLSFGSTISGKHKLNAWNGVMQILNELLKSRRLELQVTEKIVTILWEKRKSYTTEPLRTVFCSILSTVVCQADVRFGHRKVPTIDSILKYSLSLMPNVASLPSAAALTETIVRFRTVSREGLRNTWDTVSRTSSGSFEVVRLISALISVTEFDENSRFANDERVRSWSFRKDIIEWVLLDPNAHSHKLLYQLCQYHPTYCYESEASSSDDSLLQTLKLCKLACSPAPPSAPKALRPLEASIEEIVRYVHDKLKSILATEITLPAFVLCHEFALKYPDRSYEFNKMYKKLYQIMEDQEEDEFLQSARHFSKWPQNLTLPIQKQTINCMAVFFEANLDNQLVDLCQWSDRRKVLVEMLAELAATRSEIRDKLQKSMPFNKFVKECIMENRGDLYEMTKRFEKYSFLLSIRNLIVTRMIITNEAARLLGDGETISETDIFIIEKRTLSTCIRNVSEGKELSGYTLDPYTVAANVHNVHFDHINVEIYLELLKKSPFFAQNIVRHLLRQNGKEAEEETWHLHATVLKIVMKDEKLLAVCVATIPNMVRYLKVYQIHFSPKSNAAKFLHLDMESISHCQSYLRKPTKSSNLITAANFLTLFGCEKRTWKRPILRFWSIFKQQPAMCCEKLLIFAEECVELGLNHRIACLLRALTTSEFCRKALCDEYLKIAFQLTYRSIFLILSKNECRPEIVELCDDMNLRYDLLQHQIKHVAAHHLEHFERFETKIAFSVEKFLKSGIDGIDFEDLGLVEFYKQLNENLTEDAIRSNEARNIYIVDILSTIWLQLPSIRPQILPILARFKHISPAWTNFPQPPHISTNEKSFLQHLRFHLYLKMMNISKSMTQGEYATCIMMLLTSYDSSHFVADLIEKKQLGKLKLQQRRNVLCILSRLLKDQAVMGDEDETIIDPILFKAITKASAVFEDTAACIVPFLFKICVDFKGKYDKCVINLLGCLKGVNAEDEIVVRCLAECVDSIGLNVIARYERLNIETHSEFGVKWFFKLSRLFLKHGFTTHSFAIANILFDRLSARKRNTMMIDRTSLDRIDRSQELINLLVEIYVAEGNSVALSSLPPAVQNRPDVRQVMNKSSKEWLKLLSSNQMDSWELTIVQWMCGIQFNAITGDKYLNSILRCNFNEYTKKIDSPLKFVYFQLFHLSTSTLEIEEAISSMPLAPTIDQMRLMIIANATASFEPQSVEEHVVRAVRELRETSNRRKSGGNVKGINEKTTRMVKLAEMLTENKAYDAAINLLDTWEHECLQWTSVAAESIDIDLIRICKQHVTCRSGDPRMADINLRTMHPRVPVMSDLAIAEWSLALSKITIEYRNDMEEGIRILEFGCKHLQNKDSVETRLKVLLKLHSVCIGQLSKLEEYRETRTYRMKQQAVTAFEQQIQNSCRTSLARGNSGDEWTKKTVQRVRKEHQFEKNDLEKVDNSLNSAARKAVSSGFDALLCISQLEDDDEAIRASSLIIFPLIDVIYKYETDVGVIALLKEHTKSKLPSKLWISATSHIASKCFSIEKSQITRHLSQILCHLIYDYPYHVLHTILMYDDEKNASKVKGFLKTIFDARADQRDSSKLKEIVITIREAHQAYREIAMLDVRGNVRIQRVEINGKTMYRWPHDLKIFKCKLRQLPIPTISQKIGCPGDYSTTDLITWKRWKDVFTIADGISTPKIWEIEGSDGKWYKTVWKKDDVRQDVLVEQMFDVTNNMLEKAMLRTYNVVPLDTECGVIEFCGGTVSLKEVMCGVTREGGLHREFNSEEVSASKVSSMMRQVQTESTETRRQVFVEICQQYSPVFRHFFYTNFSTAQIWRQKIINYRQSLATWSIVCYIVGLGDRHASNILFDQKLCTFVHIDLGMILEYSKRTLPVPEQVPFRITRDVLDPILIEGIENGQLAEECTQIMEKLKENGKVILGVASALLRETMTNFREAEQAAGRPSYISEMAIGRLREKLRGTDDGVTAQSSNLQIRRLLREATSADNLSRMFCGWMPFL
The following text describes a protein:
Function:
Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon.
Miscellaneous:
MISCELLANEOUS: The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.
Subcellular Localization:
Periplasm.
Sequence:
MSKRTFAVILTLLCSFCIGQALAGGIVLQRTRVIYDASRKEAALPVANKGAETPYLLQSWVDNIDGKSRAPFIITPPLFRLEAGDDSSLRIIKTADNLPENKESLFYINVRAIPAKKKSDDVNANELTLVFKTRIKMFYRPAHLKGRVNDAWKSLEFKRSDHSLNIYNPTEYYVVFAGLAVDKTDLTSKIEYIAPGEHKQLPLPASGGKNVKWAAINDYGGSSGTETRPLQ
The following text describes a protein:
Function:
Catalyzes the addition of sulfite to phosphoenolpyruvate (PEP) to yield (2R)-phospho-3-sulfolactate (PSL).
Miscellaneous:
MISCELLANEOUS: The enzyme is stereospecific.
Sequence:
MKAFEFLYEDFQRGLTVVLDKGLPPKFVEDYLKVCGDYIDFVKFGWGTSAVIDRDVVKEKINYYKDWGIKVYPGGTLFEYAYSKGKFDEFLNECEKLGFEAVEISDGSSDISLEERKNAIKRAKDNGFMVLTEVGKKMPDKDKQLTIDDRIKLINFDLDAGADYVIIEGRESGKGIGLFDKEGKVKENELDVLAKNVDINKVIFEAPQKSQQVAFILKFGSSVNLANIAFDEVISLETLRRGLRGDTFGKV
The following text describes a protein:
Function:
Required for pre-mRNA splicing as a component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA. Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses.
Subcellular Localization:
Nucleus. Nucleus, nucleoplasm. Cytoplasm.
Sequence:
MATPAGLERWVQDELHSVLGLSERHVAQFLIGTAQRCTSAEEFVQRLRDTDTLDLSGPARDFALRLWNKVPRKAVVEKPARAAEREARALLEKNRSYRLLEDSEESSEETVSRAGSSLQKKRKKRKHLRKKREEEEEEEEEEASEKGKKKTGGSKQQTEKPESEDEWERTERERLQDLEERDAFAERVRQRDKDRTRNVLERSDKKAYEEAQKRLKMAEEDRKAMVPELRKKSRREYLAKREREKLEDLEAELADEEFLFGDVELSRHERQELKYKRRVRDLAREYRAAGEQEKLEATNRYHMPKETRGQPARAVDLVEEESGAPGEEQRRWEEARLGAASLKFGARDAASQEPKYQLVLEEEETIEFVRATQLQGNEEPSAPPTSTQAQQKESIQAVRRSLPVFPFREELLAAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTNKGMKIACTQPRRVAAMSVAARVAREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLSEPDLASYSVVMVDEAHERTLHTDILFGLIKDVARFRPELKVLVASATMDTARFSTFFDDAPVFRIPGRRFPVDIFYTKAPEADYLEACVVSVLQIHVTQPPGDILVFLTGQEEIEAACEMLQDRCRRLGSKIRELLVLPIYANLPSDMQARIFQPTPPGARKVVVATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQLYALGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSIFYRPKDKVVHADNARVNFFLPGGDHLVLLNVYTQWAESGYSSQWCYENFVQFRSMRRARDVREQLEGLLERVEVGLSSCQGDYIRVRKAITAGYFYHTARLTRSGYRTVKQQQTVFIHPNSSLFEQQPRWLLYHELVLTTKEFMRQVLEIESSWLLEVAPHYYKAKELEDPHAKKMPKKIGKTREELG
The following text describes a protein:
Function:
May be involved in pre-mRNA splicing.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDEELQLKNWTELHNHIKSVLDRLDESRINESFQELLEVNVIRGRGILASEVVREERVVRQGAVLGALVELFEDYIPELGIMVSREALLLFLKSFRGGRTKYCYGLLALLCQLCNSDVMHEIGLLQLADLLLEVPRDRAVGMLCFMLGQAGAHLMNVCRTAHDQLLARLTDMLHDGKLSPTSSNRIQELLRLRRSNYKGQATKFSLPDHGVCTHRVTLELDIPARLEPDSSLGKFYVDNQFFDTEERFAALRRQALERFLGQQQQQAEPVKDMTNAEEVQYKKQIYLILKGSLTGDEAAHKLLKLRPDASQKATIVEIVVKACAQEQTYTKFYGILAERLCGSHRNWPTSFTNLFRDLYGTLHEFEPNQLRNMGKFWGHMLAADHIGLNLFECVHLSEHRTTPSSRVFLKFIFQELVADLGIAEVRKRLEDENAQPLVQGLFPKEGNADTVFAINYFTAIGLGVLTESMRTSLPTQAKSDSGNMSPNGQTLSYPSSRVPRRTRSRSPPRTRVRGDSPQRARVEQRYSRYDPGPAHRDRRRSRLSVTPPPRRNIH
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
Sequence:
MAQYLLLSFNQKVPATANGRSLETIVQNASQGFGTVKEFKVSNELAKFTSTDQLMSVADELTKIDTIAFGLVTRAARSIQDLAKKITSDHNDGFADVCPQETFGQVDIPQLHVEVDDENDEEQLKFDEALEKWKWNETIFSSNRLIDEMHKNLQSEVSRMEEDLRTSGTAFTEAQTRLNNLRRRNEGSLLVRSLDPIGSKMQLVQSLEDYKASKAVKSPIYVDTANLTTVLVVVRSANGQQFEKGYELAESYIVPNSCQKLEQDGDFICYAVTLLRANVDDYKTAAKEKGWHVRDFKYSATMREDMIKEAKDAVDHYLNECKKYKEILENTFSHLSVVWMHIRALRVFVESTLLYGIPPNFKAYLIKSNTKGMQRIHKNLEQVFGDDMGGDDDDGADVDSEYHPYVSFNFNLLGLI
The following text describes a protein:
Function:
May be an angiogenesis inhibitor.
Subcellular Localization:
Membrane; Single-pass type II membrane protein. Nucleus envelope.
Sequence:
MAKNPPENCEGCHILNAEALKSKKIRKSLKICGLVFGILALTLIVLFWGSKHFWPEVSKKTYGMEHTFYSNGEKKKISMEIDPITRTEIFRSGNGTDETLEVHDFKNGYTGIYFVGLQKCFIKTQIKVIPEFSEPEEEIDENEEITTTFFEQSVIWVPAEKPIENRDFLKNSKILEICDNVTMYWINPTLIAVSELQDFEEDGEDLHFPTSEKKGIDQNEQWVVPQVKVEKTRRTRQASEEDLPVNDYTENGIEFDPMLDERGYCCIYCRRGNRYCRRVCEPLLGYYPYPYCYQGGRVICRVIMPCNWWVARMLGRV
The following text describes a protein:
Function:
Disulfide oxidoreductase that catalyzes the oxidation of reduced, unfolded secreted proteins to form disulfide bonds. Despite a weak homology to thioredoxin this cannot serve as a substrate for thioredoxin reductase.
Subcellular Localization:
Secreted.
Sequence:
MTHSRLIGALTVVAIIVTACGSQPKSQPAVAPTGDAAAATQVPAGQTVPAQLQFSAKTLDGHDFHGESLLGKPAVLWFWAPWCPTCQGEAPVVGQVAASHPEVTFVGVAGLDQVPAMQEFVNKYPVKTFTQLADTDGSVWANFGVTQQPAYAFVDPHGNVDVVRGRMSQDELTRRVTALTSR
The following text describes a protein:
Function:
Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a kinase-independent manner to regulate essential mitochondrial structural proteins OPA1 and IMMT. The action of this enzyme is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
Sequence:
MARRALKLASWTSMALAASGFYLYSKEYLDLNDFGAVRVGRAVATTAVISYDYLTSLRRVPYGSKEYLQLRSKVHLRSARRLCELCCANRGTFIKVGQHLGALDYLLPEEYTSTLKVLHSQAPQSSMQEVRQVIREDLGKEIHDLFVSFDDTPLGAASLAQVHKAVLHDGRTVAVKVQHPKVQAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVAQMLKHFDFLKVPRIHWELSTKRVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKRPGSEKAEIVLLDHGLYQFRLDYCHLWQSLIWTDMKSVKKYSQRLGAGDLYPLFACMLTARSWNSVNTGIGRTPVTATEPTTSPRSASSSTTCHARCCSSSRPTTCCVASRLPWAPAPVPAPSSTCRVAASGHWLRTRRRTPVHSSKGPRSLLGRPSAYGRSTFMNSFCV
The following text describes a protein:
Function:
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Sequence:
MEDSQAKEQTIKQAPLSLKNLNQSTTDLSNMKILIIHTEWNKTIINNLLKFSILTLQSLNLKAENILIQSVPGSYELPWACNSVLSNPTMHKDIDAIIAMGVLIKGDTMHFEYIADSVSQKLMEVSIKHNKPIIFGVLTCLTEAQALIRSGLDPSSPSNHNHAIDWAKAAVDCALNSRRFAQDDLSSTHHHFLTAEDPSLVA