lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a component of the ISW1A complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1A complex represses gene expression at initiation through specific positioning of a promoter proximal dinucleosome.
Miscellaneous:
MISCELLANEOUS: Present with 1770 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDSPSNSIQNLQQEAQGSSSAQLADHDHDRVSMAMPLQTDQSVSVSQSSDNLRRSRRVPKPRTSIYDEYEEELKERANKPKRKRPAPPKKKAPSTQNSKSNDKVEKKKTTSIAKDGKPTLKTNDKKVAPKPKPAHEQVEPALIPSNWTSVIPLLTSDFKNQYSVISRLKNPNMKPVPYAGDIIKLMAFINKFSSFFHSDLQNLSFQDFEVGLDLYPGDPNGSAAGIVKGPEDTSLLLYPDFMAIKDIVYCQDKMNLLFLSLLDLTFTENFDGKSAKKKGPLTTWENLKSSSKKVFSNPLYRLRLVAREWGYPREWRQQLPSDQDISKPKTALFEQDEQTPVVDPSHPEILTPNIYTWNANEPLPLESNPLYNREMDKNGILALKPMDRVVLLRALTDWCASHSSAIHDEIYKLTHGKKDPVFGIQTQQVPRYTIEGVDNTINQFKKLCSLIQSRYEIRSKKKHFVKQLKEGKKPDLSRKLEILKEIKAELKNAVKSEKDELLFSLYDKWVPLFEGELPDQPLANPFSERLYKLRLQEFFLGRVPHIGDFYMPRLHSYGDSLEMSTFTDLRNLQALLSKFKNNEYNAFTLFENDGQSMSAQFKLFYHDTPSLAHDVARGRNTSGKVYWYELCHDSATLLEFLEFLDYKIVKPQDEKKEGNEKEKEALNNEAHILEQKSTTDNNPSINTNPLPKDAKYNTARKKLQILKEFLSDYYFILRQFEQMKVQFADMKPGKRQLRRIQRQTVNYNTEYDSEEYVDDEEDDEADIYDDNDNDSSFDDGRVKRQRT
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is responsible for growth on MurNAc as the sole source of carbon and energy. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring.
Miscellaneous:
MISCELLANEOUS: The PTS domain EIIA required for activity was shown to be the crr-encoded enzyme IIA-glucose, EIIA-Glc.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain; The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.
Sequence:
MAKEISSELLNTILTRVGGPGNIASCGNCMTRLRLGVHDSSLVDPNIKTLEGVKGVILTSDQVQVVFGPGKAHRAAKAMSELLGEAPVQDAAEIAAQNKRQLKAKQTSGVQQFLAKFATIFTPLIPGFIAAGLLLGIATLIATVMHVPADAQGTLPDALNFMKVFSKGLFTFLVILVGYNAAQAFGGTGVNGAIIAALFLLGYNPAATTGYYAGFHDFFGLPIDPRGNIIGVLIAAWACARIEGMVRRFMPDDLDMLLTSLITLLITATLAYLIIMPLGGWLFEGMSWLFMHLNSNPFGCAVLAGLFLIAVVFGVHQGFIPVYLALMDSQGFNSLFPILSMAGAGQVGAALALYWRAQPHSALRSQVRGAIIPGLLGVGEPLIYGVTLPRMKPFVTACLGGAAGGLFIGLIAWWGLPMGLNSAFGPSGLVALPLMTSAQGILPAMAVYAGGILVAWVCGFIFTTLFGCRNVNLD
The following text describes a protein:
Function:
Catalyzes the transfer of a 4'-phosphopantetheine moiety from coenzyme A to a serine residue of acceptor proteins, such as alpha-aminoadipate reductase. Necessary for alpha-aminoadipate reductase activity.
Miscellaneous:
MISCELLANEOUS: Present with 623 molecules/cell in log phase SD medium.
Sequence:
MVKTTEVVSEVSKVAGVRPWAGIFVVEIQEDILADEFTFEALMRTLPLASQARILNKKSFHDRCSNLCSQLLQLFGCSIVTGLNFQELKFDKGSFGKPFLDNNRFLPFSMTIGEQYVAMFLVKCVSTDEYQDVGIDIASPCNYGGREELELFKEVFSEREFNGLLKASDPCTIFTYLWSLKESYTKFTGTGLNTDLSLIDFGAISFFPAEGASMCITLDEVPLIFHSQWFNNEIVTICMPKSISDKINTNRPKLYNISLSTLIDYFIENDGL
The following text describes a protein:
Function:
Catalyzes the reduction of NADP(+) with F420H(2) via hydride transfer, and the reverse reaction, i.e. the reduction of F420 with NADPH. Probably functions in the regeneration of NADPH required in biosynthetic reactions.
Sequence:
MKIAILGGTGDQGFGLALRLAKNNKIIIGSRKKEKAEEAAKKAKEILKQRGIEADIIGLENKDAAKEGDVVILSLPYEYTLSTIKQLKEELKGKIVVSIGVPLATAIGDKPTRLLFPPDGSVAEMVQNVLKESKVVSAFQNVCHAVLEDLDNPVDCDILVCGNDEEAKKVVIDLANQIDGVRAIDCGNLEKSRIIEAITPLLIGLNIKYKSKGTGIRITNLEI
The following text describes a protein:
Function:
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
Subcellular Localization:
Nucleus.
Domain:
The N-terminal half of the protein contains two conserved domains I and II. Domain I includes a slightly degenerated ERF-associated amphiphilic repression (EAR) motif which seems to be involved in the activity of transcriptional repression. Domain II is required for the correct degradation of the protein through the SCF-mediated ubiquitin-proteasome pathway. Interactions between Aux/IAA proteins and auxin response factors (ARFs) occur through their C-terminal dimerization domains III and IV.
Sequence:
MELDLGLSLSPHKSSKLGFNFDLNKHCAIEGAASCLGTEKLRFEATFGLGNVEENCYMPKQRLFALNGQPNEEDEDPLESESSIVYDDEEENSEVVGWPPVKTCMIKYGSYHHRHIRNHHHCPYHHRGRRITAMNNNISNPTTATVGSSSSSSISSRSSMYVKVKMDGVAIARKVDIKLFNSYESLTNSLITMFTEYEDCDREDTNYTFTFQGKEGDWLLRGDVTWKIFAESVHRISIIRDRPCAYTRCLF
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subcellular Localization:
Cell projection, growth cone. Cytoplasm, perinuclear region.
Sequence:
MASKMDDVSSPSLAYMVSSSSFNPEKCTYIWSEEIECIIFNADTFKIICSELCSDLEAEMYQLSHLLAEQRSLLKAQEEMSLFGNKDSGSNSKPINKEEKSISSIEAVEGLSNIIDMTDLQCIYEGGLLEIDTSTYLPKQKIRAFLLHDSMIIASIITNRRGPVRYKFQALFELENVAVVNLKSSEGVKDAFKILLFPETHLYQAESAQAKNDWLNHIEECKISFKLKLEQEVTQGDLERQEGDMNPFEVEDEDDHDTNPFKSTESSTSAYNGNPFLEDETNPFLSGSAGSLTINRQRSNTSNNITENAVTPKSSKVWLRDLPEDLDVCIAQRDFEKAMELIDKTNSFLKESSNTQALKEIKVRLDHRVKQLVEALIEELDCHQSILLHGGPRATRRAVSLLVRLGRATEACQLFLRNRSEAIKQSLRQLKIEGATALYISKLSSVFFMSLIETGREFQKSFVDNSGFCSAFVVWANTELQNFVSRFTRQVFHRNIGLAAIGVCVGIATENCDKLNEIGLDLKFSMQHMLLKELMEALFDCRDQLVAAARQRATEEQWQPQRFERNHERLTNLVGEMESCGIKEFGHLVIDDCQVNLSSATVAFTKSVIGFLEDGLRVNTPELHGVLVECVADLFKNQVLQFEATLKSSHFKAQRPFIIQNAEFVLETILPIVKKKLKRQTGHDPTSVTELSKELTRLQNIAETR
The following text describes a protein:
Function:
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF7 activates directly the mRNA 3'-processing machinery. Binds to pA signals in RNA substrates.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSEGVDLIDIYADEEFNQDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPSPKPNNKTPAILYTYSGLRNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRECVRVPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEEIMKRNRAISSSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKRHRSRERSPSRSRESSRRHRDLLHNEDRHDDYFPERNREHERHRDRERDRHH
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MEKNIKSESHLLKYIFGDVPFEQIVRETKDIIPFKICHNQDRINGNSIYYRCRTCEKSEWSCICSECFKNGHHEGHEYQAFTSTGTCTCDCGNEKFWKKEGFCSKHGHQFKGSAIEKLPESLKNYPNKIMEIIDYLGRIIDNKESLLTSEIYWNVLSLLNQVNIFFLINAELLNRYIPKEWKTEYQEINKYEFISYFEYFYQFLFLNPITTYPIQILDYMTSFISEIEVLHFPLERIHDLMFMTINLPTTNEMVSNKIAQIIVISRPKEVFSKEIFSTTRMQKLLSLIKKFIRQSKIKPILITYIDNLIWVVHYYLSGIQPTENIHEGLLEDLLDVLCESSNLFPNLIKEGEHAEFDDTRITFVSWIPSLMNDILKIIKAFTPHYLYIHFPLIHQKLMSYINTVLDKVPILLINNEKYYYRQIGKNQSVSPITFILPFYTKVLILFKLNNIEFNIPIEDCKKIVQIALFPVIYKEQIVNNEWIRNGVEVFIQYQQVVSLYLKEPLLNTVQLLQFLAEIIGFDYILIEMMIGIQILNCDSLLTKEISQYNEKRKTNLQYELNEETQNENDNSVITIQEINNIIATLNSMTGQSLNEDEEIIRDELLRRLQEYINSDIPKVQNQMINDETNNEEEKEKRIENKEKEEEELNDLIIEINEPLNEFINKYFIKNNQRITSILRLILEIERSNIHQFILDNTELMKIYTLHMIAAGITSGKEILEKVPFKDLQFETLYDEICERKGIIRKEWMGKINPVFNLFGDKERESLLENTLFKQKSIKNHRYQYDNYYNKWNGSKIICSNLLIYDIIEICRKRECDNVLLYYILMYLSDVHYLNIQINNKDTELIELGKWIGINEKLIFESKEVIKEINGQIKKGFDLIVQEQELSPSNKQKNKKKLMLNKFKKMQSNFKIDEIEIEEIEEEIHEKDICVICQTQKGSPLGRMIGIMTNCSVEIERKKSGGLVACPFCVSSCQHYIHYQCFIDLIKTQRQTCPICLKFFKYFIPLSSTIKKYHHFGVKEAEDIFEFLLVSCNNNIHTFIDIIFSTIISYEMVIRHGGEITNEDKDIVNSLFLGVKALIQNDDTFQTFFEERKRKFDPLMFYIYNRALNKDPKEVYLSNCNIIMSIVTSSDKRFQLDSITPFIKTLTLKGLDQCVTLEDAVNKMSIQFEKCVSLFEECIEGSVPQLKTIDFIPQAEGSDFCIQAPAISHLLPLINLPSNFSEFIEKYSVCQCCVCNQHISKFSEMKICMICGKPICESGSCFNNHCQECSSGYGVIFSVKKAGIYLYDEVCRGIVVYENKFGEPYDIIFIQQSQYYLNQKNVDSFKKKFYRGNLLTDASFNLM
The following text describes a protein:
Function:
Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.
Sequence:
MTNPNPFPRRMSSFASANNGSRPVRSAGFSHLLNPSPDSGSHGSGASSHTGAPFSSLDAGAAHLGNAPHGLDEGRGSHRTSGADLPSFSRAFDMFTSKEPLLAGLNTTYSGVGSSASVSKTGFLSPSYLRGSGYLGKLAEQHKAKLMADRETTMSKGPSGTVFAGNTGNTESRSVTLHTKLPSGIHRGVALNLIERPPASAEFEDAVSPLPTRWNSDDKDHTVEVFGDGYEVKYTGSKGSEHEAGAIRADNPMPMQCGVYYFEVMVFSKKREDNIIAIGFETRKAQLSRFPGWEGESWAYHGNDGKIFASGSNSGRSYGPTYGAGDTVGCLVNFRTNQVLFTKNGEELEIAFKDPSFRDPTKSFYPAVGLKRPGDHIWVNFGQIPFQYDIDGYMKKQQKMVTDKIRSTDTANLAPPLNDTELIQQLVLQFLQHDGYVGTARAFAEEIHMEKQALNMDADVPVEGVNIKDDEDANNRQQIRRAILEGDIDQALIYTNQFYPKVLEENGQVYFRLRCRKFIEMIRREAEMNSSLQEAGVKAKSTSQGRHHTGNDTQRTYSQNPGGEDEMMTEGEEEMMDTEEDGSELRTGDPEDETMAMRAAGVSELCQDALEYGQELRDEFKNDPSHEVSKHLNEIFALMAYPNPLEVKEVAHLLDGKGRVAVAEELNSAILTSLGKSSRAALENLYAQTTVLLEDLRKDGGDGAFVTIQNILDDIPKAQVN
The following text describes a protein:
Function:
A DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid. Cooperatively binds to the centromere-like site (tubC), which may seed filament formation by the TubZ polymerizing GTPase, stabilizing TubZ filaments. TubR-tubC complexes track the depolymerizing minus end of the filament, probably pulling plasmid within the cell. Required for plasmid replication. Negatively regulates levels of TubZ; its effect on RNA expression has not been shown (Probable). Specifically binds iterons, 12-bp imperfect direct repeats that function as a plasmid origin of replication. Four TubR dimers bind to tubC, forming an extended bent DNA-protein filament with protein wrapping helically around the outside of the DNA.
Miscellaneous:
MISCELLANEOUS: The pBtoxis plasmid encodes all the major endotoxin proteins (Cyt1Aa, Cry4Aa, Cry4Ba, and Cry11Aa) responsible for the mosquito larvicidal activity of strain 4Q2.
Domain:
Although this has the same function as TubR of B.cereus strain ATCC 10987 there is little sequence homology and the dimerization interface is different.
Sequence:
MNRDHFYTLNIAEIAERIGNDDCAYQVLMAFINENGEAQMLNKTAVAEMIQLSKPTVFATVNSFYCAGYIDETRVGRSKIYTLSDLGVEIVECFKQKAMEMRNL
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MGRGRSEIKRIENPTQRQSTFYKRRDGLFKKARELAVLCDADLLLLLFSASGKLYHFLSPTVPSVREFVERYEATTHTKVWADIRQERRAELEKVGSMCDLLEKQLRFMTVDDGEEYTVPSLEALEHNLEAAMRKVRSEKDRKIGGEICYLQNIIRGRQEERYGLCDKIAHAQTLKDVECGSTSLSNGLDLKLGFN
The following text describes a protein:
Function:
Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDGFDRAPGAGRGRSRGLGRGGGGPEGGGFPNGAGPAERPRHPPPPQPKAPGFLQPPPLRQPRTAPPPGAQCEVPAGPQRPPRPGALPEQARPLRAPPISQDTVPQQNSESAMAKPQVVVAPVLMSKLSVNAPEFYPSGYSSNYAESYEDGCEDYPTLSEYVQDFLNHLTEQPGSFETEIEQFAETLNGWVTTDDALQELVELIYQQATSIPNFSYMGARLCNYLSHHLTISPQSGNFRQLLLKRCRTEYEVKDQAAKGDEVTRKRFHAFVLFLGELYLNLEIKGTNGQVTRADILQVGLRELLNALFSNPMDDNLICAVKLLKLTGSVLEDAWKEKGKTDMEEIIQRIENVVLDANCSRDVKQMLLKLVELRSSNWGRVHATSTYREATPENDPNYFMNEPTFYTSDGVPFTAADPDYQEKYQELLEREDFFPDYEENGTDLSGAGDPYLDDIDDEMDPEIEEAYEKFCLESERKRKQ
The following text describes a protein:
Function:
Cell wall protein necessary for cell wall integrity.
Subcellular Localization:
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor.
Sequence:
MQFSTVASIAAIAAVASAASNITTATVTEESTTLVTITSCEDHVCSETVSPALVSTATVTVNDVITQYTTWCPLPTTEAPKNTTSPAPTEKPTEKPTEKPTQQGSSTQTVTSYTGAAVKALPAAGALLAGAAALLL
The following text describes a protein:
Function:
Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity).
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane.
Sequence:
MVPPVQVSPLIKFGRYSALILGMAYGAKRYSYLKPRAEEERRIAAEEKKRLDELKRIERELAEAEDVSIFK
The following text describes a protein:
Function:
This protein specifies the body segmentation pattern. It is required for the development of the central nervous system. Transcriptional regulator that repress activated promoters (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MALEDRCSPQSAPSPPHHHHSSQSPTSTTTVTMATASPVPACTTTTTTTSTSGASAASSPTRDEMSLVVPISPLHIKQEPLGSDGPMPAQPPHHHQHPHHHQLPHHPHHQHHPQQQPSPQTSPPASISFSITNILSDRFGKATAEQQQQPHPQPPAIREPISPGPIHPAVLLPYPQHVLHPAHHPALLHPAYHTGLHHYYQPSPSHPQPIVPQPQRASLERRDSLFRPYDISKSPRLCSSNGSSSATPLPLHPYHTDSDCSTQDSTSAPSPATYGDIASPSSASSAMTTPVTTSSPTGSVYDYSRKASALDHRAALLNGFSAAASYPKLHEEIINPPQVPGEADRIANEGGTGCGGHGCCGGSATPHNMPPLGSLCKTVSQIGQHVAGTGSLNGSGSAANGASNGGSGAPATAKPTPKPIPKPAPSSETNGSSSQDAGMESSDDAKSETSSTKDGSENGSNLWPAWVYCTRYSDRPSSGPRYRRTKQPKEKGDSEEKRPRTAFSNAQLQRLKNEFNENRYLTEKRRQTLSAELGLNEAQIKIWFQNKRAKIKKSSSEKNPLALQLMAQGLYNHSTVPLTKEEEELEMRMNGQIP
The following text describes a protein:
Function:
Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as secondary nitrogen source when primary sources are limiting (By similarity).
Sequence:
MEAKKIYAQALTDEAFAPFGSVVQQKDDVKMVSANGGTAKKYLKVSESIQNYEKSSSASTRKGVWNFFSTHPSVHPANDEHAAFQISVLERHPFTTQTFIPMCRSSDEQAYLIAVAPNAPDGMPDWNQTQAFVAKGAQGVTYSAGVWHAPMVTIGKETMLAAFNYENGVAEDDCQVQSTESPIEVFIKIST
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGNEPDEARVGGVPEMPKVYEKKRTCTDIVFLCLFFVMLLAFAALGIIAFVDGEAKDSLNGRDRTGRYCGSGSPPEGFAESIPQGAPFQSKVWGENKYLWYPFPLKQTAMSLNPLLYLSLGLCVQQCPMANERLLERLLKNPSSVTEEEKNTMKVYSYGGSSVVESGMQPVNHAFPVYHTGPILRRCLPTITQPPSVRDLLMTSEYSQRVYAFVLKGVLEVKASWKVFLCAAAACTLLCFIFLFLVRFLISFVVWASIIACFLLLLSGGCICIQLYLNDGHFMNLHLDVTKYSVLLLCVAIGLWIGALVYVFVIIGACPRIRLVCALAKIASRVVDNAPSTVLLPILMNVAILCLLVWSILVALGLYNARRKTGKISFVPVTDAIGINDGSFKGIGETKFYQGVVEGVEHRYALVYLLFGELFAFLWCVSFLNAVSFTSISFVSTFWYFSNLNGGKKRVPFFGVLRAFVWTVFYHAGTLALGSLLIAILQIVRILLVYAAEKAEEAVDRHDLIQCLHCYLQYALLCFENFVSSINKNIYVVVCLTSGSFCTSACTGLSVLKGHSSDLFLISWMVLCVKILGKLFVTVGTVVTSYLLFKHTTLAPGVDSMVMPLILIGIGAYFLSGPFFDVFDSSTLALLICYCYDHHINQSVGIFYVPAELEHQLSDYSQKKKLRRLKNQQAAAHRRG
The following text describes a protein:
Function:
Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Sequence:
AMEESKNKEKTQPEKIEEKGQQSAGKDKEKKEEQELSEEDKQLQEELEMLVERLSEEDTSLYRPALEELRRQIRSSTTSMTSVPKPLKFLRPHYGKLKEIYEAMPAGDNKRFCADVVSVLAMTMSGDRECLKYRLLGSQEELASWGHEYVRHLAGEVAKEWQEVEESDKVQQETLLKLVKEIVPYNMGHNAEHEACDLLMEIERLDMLELYIDENAYAKVCLYLTSCVSYVPEPENSALLKCALSIFRRFNRYPEALRLALMLNNIELVENIFTSCKDIVIQKQMAFMLGRHGVFLELNEDVEDYEDLTEIMSNVQLNSNFLALARELDIMEPKVPDDIYKTHLENNRFGGSGSQVDSARMNLASSFVNGFVNAAFGQDKLLTDDGNKWLYKNKDHGMLSAAASLGMILLWDVDGGLTQIDKYLYSSEDYIKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNIMRIGAIFGLGLAYAGSNREDVLSLLLPVMGDSKSSMEVVGVTALACGMIAVGSCNNDVTPTIVQTIMEKSEQELKDTYARWLPLGLGLNHLGKGEAIETTLAALQVVPEPFRSFANTLVEICAYAGSGNVLKVQQLLHICSEHYDNKDKEEDKDKKDKKEKEKKESSPDMGSHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLISFLDVKNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLAVSVRVGQAVDVVGQAGKPKAITGFQTHTTPVLLAHGERAELATEEYLPVTPILEGFVILRKNPNYDA
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MASVDVRDNLLGISWVDSGWVPILNPGNVLDYFSERSNPFYDRTCNNEVVKMQRLTLDHLNQMVGVEYILLHAQEPILYIIRKQQRQSPSQVIPLADYYIIAGVVYQAPDLGSVIGSRVLSAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDQDDKEKAKPKSKKKEEPSSLFQRQRVDTLLLDLRQKFPPAFYQPKPGEKPVPVEVKKEPEPPAEAAKQEEREATKTPAPAPPSKAPPEKRPRLQ
The following text describes a protein:
Function:
Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway. As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
Sequence:
MGTIHLFRKPQRSFFGKLLREFRLVAADRRSWKILLFGVINLICTGFLLMWCSSTNSIALTAYTYLTIFDLFSLMTCLISYWVTMRKPSPVYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLEQPEIHTGRLLVGTFVALSFNLFTMLSIRNKPFAYVSEAASTSWLQEHVADLSRSLCGIIPGLSSIFLPRMNPFVLIDLAGAFALCITYMLIEINNYFAVDTASAIAIALMTFGTMYPMSVYSGKVLLQTTPPHVIGQLDKLIREVSTLDGVLEVRNEHFWTLGFGSLAGSVHVRIRRDANEQMVLAHVTNRLYTLVSTLTVQIFKDDWIRPALLSGPVAANVLNFTDHHIIPMPLLKGADDLNPVTSTPAKPSSPPPEFSFNTPGKNVNPVILLNTQTRPYGFGLNHGHTPYSNMLNQGLRVPGIGATQGLRTGFTNIPSRYGTNNRIGQPRP
The following text describes a protein:
Function:
Cell signaling peptide that may regulate plant stress, growth, and development. Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MSILKETKRFMVVAMFIACVFISNNMNVAVANEIGYPGMGRGDRQPGCDHGNCPPDQPANPYHRGCEKSKRCRGPDPPALPRKMI
The following text describes a protein:
Function:
Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways (By similarity). Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor (By similarity). Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss (By similarity). IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFDIPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLKTVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINRLTGYLRN
The following text describes a protein:
Function:
Part of an export system, which is required for biosynthesis and secretion of siderophores. Essential for virulence; Overexpression of the system confers non-target based resistance to azoles, clofazimine and bedaquiline, via an efflux mechanism.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MIGTLKRAWIPLLILVVVAIAGFTVQRIRTFFGSEGILVTPKVFADDPEPFDPKVVEYEVSGSGSYVNINYLDLDAKPQRIDGAALPWSLTLKTTAPSAAPNILAQGDGTSITCRITVDGEVKDERTATGVDALTYCFVKSA
The following text describes a protein:
Function:
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Subcellular Localization:
Nucleus.
Sequence:
MSNKKEDLENDLEDIEEDLSNEESSDDGDDGVTQTKKRKKPSAATPKVKPHPPIPKLPYTDRVFIVQDNSSNSEDDFINFEIITLPSPKYEKTYCRYIKDKINNKILEINKFNSNPSSWFIDNGARNDGSMYIASNIDPLFLLIPFLEKNKTQNKNEYFEVSSVVNDPIYSNLSKITFKDEQLKLICDFKDFAGSSLYKLDDEKLLLWLRCKVKNIANHLKDNDIDIFKTSNHVKNVLSWETLYTMSIGFISEYLSDAHIKLLNESFGLLSDKAKETIQKESADLVYTEKIIEPEPSKPKKAASKKGSAKKAAAKPAPSITTTTSPFFTKVSSTSSSDDNKPKGSLISDYFSRK
The following text describes a protein:
Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.
Miscellaneous:
MISCELLANEOUS: Present with 4870 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MGKKTFREWQYFKLSITSFDQDVDDAHAIDQMTWRQWLNNALKRSYGIFGEGVEYSFLHVDDKLAYIRVNHADKDTFSSSISTYISTDELVGSPLTVSILQESSSLRLLEVTDDDRLWLKKVMEEEEQDCKCI