lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Short-chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of sordarial, a salicylic aldehyde structurally related to the phytotoxin pyriculol. The most interesting aspect of this pathway is formation of an aromatic product from the highly reducing polyketide synthase srdA. SrdA synthesizes a reduced polyketide chain from one molecule of acetyl-CoA and five molecules of malonyl-CoA. The polyketide chain is then reductively released as an aldehyde. The oxidoreductases srdC, srdD and srdE then oxidize one of the hydroxy groups to facilitate the intramolecular aldol condensation, followed by dehydration to yield a salicylic aldehyde. This aldehyde can undergo facile reduction by endogenous reductases to yield the alcohol 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene. The flavin-dependent srdI counteract against the propensity of the aldehydes to be reduced under physiological conditions and is responsible for reoxidizing 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene back to the salicylic aldehyde. This salicylic aldehyde is then selectively epoxidized by the cupin-domain-containing oxidoreductase srdB to yield the epoxide, which can be hydrolyzed stereoselectively by the hydrolase srdG to give the final product sordarial.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MAPQSTKFALITGCGAGGIGEALILEYLRRGIHPIATLLPFESSEHLDKAGITWFKLDVTNEESVVQLKKDVSELTKGRLDFLVNNAGICYTMTAIDTDVKSVQRMFDVNLFGPMRMVHHFHDMLIASSGIIVNIGSIGGVVPFVYGSSYNASKAALAHWGNSLRVELAPLGVRVLVIISGEVGTNILKNDHGRTLPEGSYYSPMAEEFKNHVHRTPDAATDRFVYAKNVVGESLKKSPTTWFWTGSYSGVIRFLHTFFPKTVFDRWFSSLFNLAKLKEAHDAAMKKKVA
The following text describes a protein:
Function:
Part of the dynein complex of multiciliated cell cilia.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Dynein axonemal particle. Note=Located in the proximal region of respiratory cilia.
Sequence:
MEIVYVYTRKRSEFGRQCNFSDRPAELHVDILPDPSQALNFIERNPCDVAIQCSHDMSEHEVNTERYDMEAHGINHVEGGWPKDINPQEMEQTIRFRKKVEKDDHYVTTISQLGSVMEHCIKQNNAINIYEEYFEETEELEGIDETPSANTVNVFRDPNEIKRTATHLSWHPDGNRKLAVAYSCLEFQRAPKDMNFESYIWDIEIPNKPELTLRPASPLVCLEYNPKDSHVLIGGCYNGQIAYWDTRKGGNPVESTVIEYSHRDPVYKVIWLQSKTGTECFSASTDGQILWWDIRKLSEPTEKLILDISKKENIDNALGAVSMEFEPTLPTKFMVGTEQGMIVSCNRKAKTPPEKIVCTYGGHHGPIYSIQRNPFFPKNFLTVGDWTARIWSEDCRESSIMWTKYHTSYLTDACWSPTRPTVFLTTKIDGTLDVWDYMYKQNNPSLSLKVSDEPLYNICMQDNGRFVACGSKMGVTTLMELSKGLYTLQRNERNLASAMFERETKREKILEARHREMRLKERSKAEPGEEVKDEKPAEDMKEIIANAEKDFFENIEAELKRKEQQEIKQSEDEHQEKEVSEEKIVHE
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MEESSTVAMLVPDIGEQEAILTAETVISSSLEIDEQRKAKTDPLIHVIQKLSKIVEHEKSQKCLLIGKKRSRSSAAMHSLENQELCEIPAKVTRSSAADIRRAEMSQIHFTPDSLAQNDGKAMSYQCSLCKFLSSSFSVLKDHIKQHGQQNEVILMCSECHITSKSQEELEAHVVNDHENNASSHTQPKAQQCVSPANSLCQRTTERNNDSTPDVPVSLDKPQAHNAQTVSMTEVGRRKWYAYEQYGMYRCLFCSYTCGQQRMLKTHAWKHAGEVDCSYPIFENENEPLGLLDSSVAAAPGGVDAVVIAIGDNELSIHNGPSVQVQICSSEPLSSSSPLEQSAEGGVHLSQSVTLDTNEEEMLEVISDVEENLIADSLLSSAQKIISSSPNKKGHVNVIVERLPNAEETLSQKHFLMNAEIEEGKNLSPTEAQLGCEGRDEVYRADKCTVDIGGLIIGWSNPEKKDSELISKGLAPDENAPPGRRRTNSESLRLHSLAAEALVTMPIRAAELTRANLGHYGNINLLDPNTGQRQVDSTLAAYSKIMSPLKNSSDGLTSFNQSSSTLVALPDGRQELSDGQVKTGISMSLLTVIEKLRERTDQNASDDDILKELQDNAQCQPISDPGLSGSSVVEYIPHADRPYRCRLCHYASGNKGYIKQHLRVHRQRQPYQCPICEHIADNSKDLETHMINHCKTRIYQCKQCEESFHYKSQLRTHEREQHSLPDPLSIATSSESRISSDTAEGRCVPEGNKSSVQKQYRCDVCDYTSTTYVGVRNHRRIHNSDKPYRCSLCGYVCSHPPSLKSHMWKHASDQNYNYEQVNKAINDAISQSGRVLGKSPGKAVVNNSEERADPLTGSSENLMSPSELIAQAPSEVVGPNENDKLSPASNTSYSLEKNSSPAPPGMEYCVLLFCCCICGFESTSKENLLDHMKEHEGEIVNIILNKDHNTTLNTN
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MTTTFTFIATLVSFLLPLVAAYGYNDLEITSWCGQTPHPESCNYFLANNQYYSGPVIKQKPDFVKALLKVTLERAQHAESNTRGLGPKCRNKLEKAAWDDCIELYEHTVERLNMTVDPHKPCNQYEMQTWLSTALTNLETCRAGFQELGVDGYMLPLMNNNVSSLISNTLAMNKEGGSPPDNYQKGGFPTWVKPGDRKLLQSSNPASQANVVVAQDGSGNYKTIGEAIAAAAKRSGSGRYVIYVKAGTYKENIEIGTKLKNIMLLGDGIGKTIITGSKSVGGGATTFNSATLIVVGDGFIGRGITVRNTAGPQNHQNIMLLGDGIGKTIITGSKSVGGGSTTFNSATLIVVGDGFIGRGITVRNTAGPQNHQAVALRSGSDLSVFYQCSFEGYQDTLYVHSNRQFYRECDIYGTVDFIFGNAAVVFQNCNIYARNPPNKTNTVTAQGRTDPNQNTGISIHNSRVMAASDLKGATGSVKTYLGRPWKQYSRTVFMKTFLDGLVDPAGWMPWSGNFALDTLYYGEYMNTGPGSSTTKRVNWKGYRVITSSTEAANATEAAKFTVGNFIAGGSWLPATNVPFTSGL
The following text describes a protein:
Function:
Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.
Sequence:
VCVCVCVCVCVCVCSYTSGIAQNRSALQQLGITHILNAAHSKRGSIGDQQYYGSSFVYCGIPADDNTHFDLDVYFKPAADFIHRALHSPDGKVLVHCIMGMSRSSTLVLAYLMLYHDMPLHTAIRRIIRKRAIYPNRNFLALLLDLDLQRKRKHRLCVLL
The following text describes a protein:
Function:
Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.
Subcellular Localization:
Membrane.
Sequence:
MDKYKVAGKFGLPDITVAEMESLASFCEAVLPSVQPPPEELSGEGDNHRNKEALRSFYSTSGSKTPVLRQSIELVTKRGTIEAYIATRLILFLLATRLGTLLICGTECLVSRWPFVEKFSELSLEKRERVLQKQFKNWILTPIRAAFVYIKVAFLFCFFSRVNPNGENPAWEAIGYRVNPDENKPSETHNERPLEKGIVETMEETEQTLLESLAHKGLEAVLDTEHDAIRIKCDVVVVGSGSGGGVAASVLAKSGLKVVVLEKGSYFTPSEHRPFEGPGLDKLYENGGILPSVDGSFMVLAGATVGGGSAVNWSACIKTPKSVLQEWSEDQNIPLFGTKEYLTAMEVVWKRMGVTEKCELESFQNQILRKGCENLGFNVENVPRNSSESHYCGSCGYGCRQGDKKGSDRTWLVDAVGHGAVILTGCKAERFILEKNGSNKGGKQMKCLGVMAKSLNGNIAKMLKIEAKVTVSAGGALLTPPLMISSGLRNRNIGKNLHLHPVLMAWGYFPDKESSNISFKGNSYEGGIITSVSKVLSEDSEVRAIIETPQLGPGSFSVLTPWTSGLDMKKRMARYSRTASLITIVRDRGSGEVKTEGRINYTVDKTDRDNLKAGLRESLRILIAAGAEEVGTHRSDGQRLICKGVNENSIQEFLDSVSTEEGAKGMTEKWNVYSSAHQMGSCRIGENEKEGAIDLNGESWEAEKLFVCDASALPSAVGVNPMITVMSTAYCISTRIAKSMTTGLSH
The following text describes a protein:
Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
Sequence:
MSLAVTSQPHAIVREKHLSENVWIRKPKPGQHVLEKMSDLSDARHLHVHRNVKGTICSGKQDYDITDQDGKLMYKAVEDSHCCCVHCCGPARAYKIIVKDPLGLELLQFHRPVRCSDTCLCCCGCGLMRMRVTEACSDVVIGDVKQRCTFIREKFDVTELVENEQTTLIGPSVTCRCFANMTFQIIDDKNSEVGEIWKRWKGAPNEN
The following text describes a protein:
Function:
The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit.
Subcellular Localization:
Secreted.
Sequence:
MKFSSVSEEKPGLLAPPAQPLTKMFQGAWLCWASLLLLVRVTQPCPVGCDCFDRKIFCSDEQLAAIPLDIPSHVTDIVFVETSFTTVGTRAFSGSPNLTKVVFLNTRVHHLEPDAFGGLPRLEDLEVTGSPFSNLSANIFSNLSSLGKLTLDFNRLAALPEDLFHHMDTLESLQLQGNQLQTLPGRLFQSLRYLRTLNLAQNLLTQLPKGMFQSLSSLQILKLSDNMFARLPEGVLSNLGSLQELFLDSNAITELSPHLFSHLLSLEKLWLQHNAISLLPVSAFSSLRNLTFLNLKDNALRTLPAGLFTHNPGLLHLSLSYNQLETVPEGSFANLRKLASLTLSHNAITHLPENVFRNLEQLVKLSLDSNNLTVLHPTLFHNLSKLQLLDLSRNQLTMLPGGIFDTNYDLFNLALLGNPWQCDCRLSYLTSWLRLYNDRIFNTHTFCAGPAYLKGQLVPNLKQEQLVCPGNPGQLGLDDREPAGSWDLAVEGRAAHRQCIYGNPEGTVLLACEEAQCRWLNIQLSSREGSDVTAMAYNSSQEWELRSTCGSVRVTVSIEAQAAGP
The following text describes a protein:
Function:
Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides.
Subcellular Localization:
Cytoplasm.
Sequence:
MPSYSIAAPAAAQATATANPFFADSTLPLHYPQFDKIKDSDFAPAFDAGMAAQLKEVDAIANQKAKPTFDNTIIALEKSGATLDRATTVFFNLVGADTNDARKKLQADYSAKFAAHRDAISLNGKLFARIQTLHDQRSKLGLDAQGVRLVEKYYSDFVRDGAKLSDADKTTLKAMNAELANLGTTFSQNVLAEVNAAAVVVDDVKQLDGLSDEQIAAAAEAAKARKLDGKYVIALLNTTGQPPLTQLKNRELRRKIYDASVSRGSHGGQYDNTALVSRIMTLRANKAKLLGFPTYAAYSLENQTAKTPEAVNAMLGKLAPAAVANAKREAADLQSMIDKEQKAARKPTFKLEAWDWAYYSEKVRQAKYNFDESQLKPYFELKNVLENGVFYAANQEYGLTFKQRTDLPTYRDDITVYDVFDADGKQLAIFIADMYARESKRGGAWMNSYVSQSELTGFKPVVANHLNIPKPPAGQPTLLTWDEVTTMFHEFGHALHGMFSDVKYPYFSGTSVPRDFVEFPSQVNEMWADEPSILKNYAKHYQNGTPMPQALLDKVIAASKFNQGFATTEYLGAAMLDQNWHQISANQVPDAAGVMAFEAKALADDGIAYPPVPPRYKTPYFSHIMGGYAAGYYAYIWSEVLDANTQQWFKQHGGLSRANGDRFRQTLLSRGGSVDAMELFQNFAGHAPQIEPLLEKRGLSAQGGDGATPEAPQSKP
The following text describes a protein:
Function:
Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides.
Subcellular Localization:
Cytoplasm.
Sequence:
MESIWRIATGQDPSREDYEGIEFWSNPERSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKDQAAAGIRGSTPRGVISVGDCLTVKGAEDVVNKPFAFELSSGSYTMFFIADNEKEKEEWINSIGRSIVQHSRSVTDSEVLDYDHRR
The following text describes a protein:
Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6; The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein; [C-domain 2]: Secreted; [Tumor necrosis factor, soluble form]: Secreted; [Tumor necrosis factor, membrane form]: Membrane; Single-pass type II membrane protein; [C-domain 1]: Secreted.
Sequence:
MRAFPALLLPCGYINAAVCTPSQQKLPQRRHQGTSQERERSNSRPPPGNNISDDTPPDKQPGDSLPLTHAALGLYHHPAGLEPPGKNAMSTESMIRDVELAEEALPKKAGGPQGSRRCLCLSLFSFLLVAGATTLFCLLHFGVIGPQREELPHGLQLINPLPQTLRSSSRTPSDKPVAHVVANPEAEGQLQWLSRRANALLANGVELTDNQLKVPSDGLYLIYSQVLFTGQGCPSTHVLLTHTISRFAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINLPAYLDFAESGQVYFGIIAL
The following text describes a protein:
Function:
Assembles to form an icosahedral capsid with a T=1 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins F. Upon virus binding to host cell, one of the spikes dissociates from the capsid and the virus interacts with LPS through the exposed EF loops on the F proteins. After the genome had been ejected, the channel formed by the F proteins at the unique fivefold axis remains open.
Subcellular Localization:
Virion.
Sequence:
MSNIQTGAERMPHDLSHLGFLAGQIGRLITISTTPVIAGDSFEMDAVGALRLSPLRRGLAIDSTVDIFTFYVPHRHVYGEQWIKFMKDGVNATPLPTVNTTGYIDHAAFLGTINPDTNKIPKHLFQGYLNIYNNYFKAPWMPDRTEANPNELNQDDARYGFRCCHLKNIWTAPLPPETELSRQMTTSTTSIDIMGLQAAYANLHTDQERDYFMQRYHDVISSFGGKTSYDADNRPLLVMRSNLWASGYDVDGTDQTSLGQFSGRVQQTYKHSVPRFFVPEHGTMFTLALVRFPPTATKEIQYLNAKGALTYTDIAGDPVLYGNLPPREISMKDVFRSGDSSKKFKIAEGQWYRYAPSYVSPAYHLLEGFPFIQEPPSGDLQERVLIRHHDYDQCFQSVQLLQWNSQVKFNVTVYRNLPTTRDSIMTS
The following text describes a protein:
Function:
Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation.
Subcellular Localization:
Nucleus.
Sequence:
MSSNDYIDNEAEESEEEYAGSNQDEDDDDDGAEDDKLSGFVTDKDETSHDDSESDSGTTGKKRYHDEDDIDDDLDEDDFDLINENTGIDLQRNKRFRRVRTLESAFDEEPEDDIMALPPEADPVVAKKPSTSEKPSAPHDDIFAEMSSDEDDDFIVDEEGRPIHEEDDEADEAMHDANDIFRIDFDYLDEGADEVEEYEEDDYLDEDIDSQDESEPRRRSRKKVSKKGRSLFEIYEPTDLEKRYLSKRDEKIRITDMPERHQLRKIAVTKADDTELDNESQWIYSQAFMNPSISNQGINYGSGSQLMITVREILALIRNEGLEIPFIAHYRKEIYRHSLQVDDLWRIYNWDIKWMYFSRRKQNMAKLFAKVQQYQYDKAKNTHDFSTFNAKIIDAEDTARLEECNTYEELQDVYTHFLLYHHKELEDLRNDASKKTTNSDDKNQSDNNEKRSGESIRRLRRRNFYTRCEDNKISHLALKFGLSPERFGKNVIESYQINEPTQYEIDPNTTARDYITKAFPTVEAVLDAAVYTVAVQLSRDPLVRRAVRLAFYERAKISCRPTKRGKKAEKEGFITHTFSVEPSASSWGSYADELKQYYFVDGFSDLIKEWNELRGRAVQKAVEDVLFEEFRKELQEKLLRESYEYVIKECCCNVRKRINVASFKIGSENDEDDEMEPYQRIMSFAFVSDRDIASYACVIDGHGEIKEIKLIKGLIVSKQPVAIAISASCRQATGVKKDLEGIVNELQSEEDLPPISVELIDPCIPRLFESSKRAKNEFPEYPPLLCHAISLARYMQEPLLELSQLLTSDDEEILCLRLHILQAEIPKPDLMEALYIEFINCINDIGIDLNLCLTNERYSSLLSFVCGLGPRKATALLKLLKKGNLRLRNRKSLVTECGMGPNLFVNCAGFIKIPTNKVDDSDYAEILDTTRIHPEAYDWARKMAIDALDYDESAEEINQATVVHDIIDQPDKLKDLDLDAFAEELKRQGFGNKSVTLYDIREELTHRYKECRQPFDSLSPGEVFYLLVDETPESLCYGQLITCRVIGIVHRRPTKDQIDRVNPERDPISNTWTCPLCLFDSFKELSEVWRHIDNNECKGIAIGVKVILDSGITGFISTKNISDKQIRTPEERVKIGMVIHCRIIKLNIDKLSVDLSCKSSDLADHDNQFSKPKDNYYDTEIEKADMEEDVKKTKKQQIPYIKRIIVHPSFHNISYKDAVEKLSHLDNGDAVFRPSRKGSDHLTLTWKVLDDIYQHVDIREEGKVNSFSLGHSLRIGNEEYEDLDEILARYVQPMAALTRDIINHRYYYVAGDTEKKELEKLLLSEKKKQPSRIPYHFSASSKYPGKFMLSYLPRNHPCYEYVTVTPEGFRFRGRLHAKLDALLHWFKRHFRDPMPGTSRGTSVSQDTPMNAVPPNVMQAVNNLTNISQSQLMSTLQSIQQKDDWLSNNNVPTYANYGYQQLSTGNSEPQKINQWENNWSSTWSAPKPAENLNKDYNDNHDRRWETPQSQQSDQKRDSQRQYDRRNRGHRDDRYRSYHSRRN
The following text describes a protein:
Function:
This protein seems to be part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) into CF(1) or is implicated in proton conduction.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane.
Sequence:
MAALQQTPITFQSRSPPPTQIISGPTAKLSFSGGLKLPKLTIKLRSNRTSRRGGGAAGSKMVASAAGSYANALADIAKSNGTLEQTTADLEKIEKISDDEAVFNFFVSPIVGEEKKRELVDEIVSSSSIQPHVANFLNILVDMKRVELIKEIVKEFEKVYNTLTDTELAVVTSVVKLESQHLAQIAKGVQRLTGSKNVRIKTVIDESLVAGFTIRYGNSGSKLIDMSVKKQLEDIAAQLEIGDIQLAV
The following text describes a protein:
Function:
Mitochondrial metal transporter involved in mitochondrial iron accumulation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNYHFSSVTSTSLNRYLFYRSSTNTVSYWSSSQFHIRLKFTTRSNCTTTITTTTTTALLSRHFYSTFSIFQRPMSTSNNKLSKEISPPPPPPGQDSHSHVHSHSHDSEHSHSHSHSGASMLHHHKHSMHEPNELLAGGASAIKTNPAVRITWIGLLVNVTLAISKGIGGVYFHSQALVADAIHSVSDMLADFLTLATVNVAAKVGTATKFPLGYGKLETVGAFSVSAILLFAGISVGWSSLLQIFEFVLPTHLYEIASHIQIGHDHSHGHGHGPVSVQPDTHSHSHGQIDPSNITTHREIPNINAAWLAGGSIIAKELLYRKTMQIAVQTNSKVLVANAWHHRVDSLTAVVALFTVAGGVLFNVAWLDSIGGIGVSILIIKAGWDSLKEAWNELIDRGEKPGSELYNKIEGIINNELQMNNELKQFKLNQLSVLSSGANTNIHMNLSTTNKNLNLQTLNQYEKRLSDLIRQDDRFVRNIFVKFDQVEEEPEKVEAKKEEDDDDDEKEVNGSNDVHSHKH
The following text describes a protein:
Function:
Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses.
Subcellular Localization:
Nucleus.
Sequence:
MEVTSNVLEDILVKKVNVMEPIVQVVQIKECNQHDLYRAALSDGTHFIPAMLGSKLKDLIENKVIQRNSLIKLLKYTVSNNSKQPLIVLNAELHKEMNSIIGKPLALQIDRNDIPKPDLSAPMTSPQRGTITASPASVTNSPSKVKMTVSPTRSNQSTMQMTTNIPIASLNQYLTSWSLIVRIISKSQMRQFQGSRPGKLFSIIMRDKNNDEIKGTFFNQEAEKFENLVEQDKVYKVSCGRVKKANERYNSTKSEFEITFDSTSSIIEIPDDNSIPANVLKFTKISDCSKMTGKTVDIISIITFIGDCQTIKTKSGSSIEKRNITVSDETGTIEVTLWGSSATEFDQKESEIFCVRNVTVSDFRGVSLNVGQSATIVVNPPDNDVKNIRNWYESLNDEKKENLKQKLLIPDYGQAATINCLSEIDEKQMCRTENGEVFCVNVMIQDMPSSRKPVYQACPNEACRGSGLIIDQETGKMICKKCNKEVTNPKLRYSLSLNVGDYSGSAYINVIGDENSFMPLINVKPEEFEIDDTTKLRTMLLKKSFFRALRVKVRGKNSEYGVKLTAISGGEVNFAEEALRIANNITASFE
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSAQDVRSILSLPPSTPLPTLSSSKKVPVPRKPDGITRELYALIGDNAPSLADAQASLAAVKYREKPALKGKKVHWEWTKFTPAARRDNPVRLGHWARITDSDPNDSVEYFGKFNLHGPSVMEYSQFEYDQHLVDPNWTLQETEYLFELLKEYDLRFIVAADRYAYVSPEGEKRKRSVEDMKDRYYTICRRLIRTRTASDPVHQQHLIQAYAFDKAREIKRKQYASDLFHLTPAEIAEEEALYVEITRMQQNERRFRADRDELMRSVMGLDSGLVEVDQSAMENAIGVDKNKKKRKAEDESAAPSPAPTPKKPAPNAGFDNSRCIYHLPTPSNANSLTSHLSQKHPPHQQAFLRGSRLPLPKPTAAGRITDLLAELGLSANRLVMPTRQNMEVFEGLLNAAAALVEMRRQVNRVEQELRVVRMQKEGLMPVTTNPSARVKGEAGVVTGGSEATVKAVTPVKEC
The following text describes a protein:
Function:
Cytoskeletal linker protein, which is essential for attachment of the centrosome to the nucleus. Required for dynein localization to the nuclear envelope. Forms a LINC (LInker of Nucleoskeleton and Cytoskeleton) complex together with unc-84, that may be involved in DNA damage repair.
Miscellaneous:
MISCELLANEOUS: In contrast to isoform a and isoform d, isoform b and isoform c contain a potential transmembrane domain which may mediate insertion into the nuclear membrane; MISCELLANEOUS: [Isoform a]: Does not contain a transmembrane domain; MISCELLANEOUS: [Isoform d]: Does not contain a transmembrane domain.
Subcellular Localization:
Nucleus membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Note=Localizes to the minus end of microtubules, proximal to the centrosome. Centrosomal localization requires sun-1 and microtubules.
Domain:
The large coiled coil domain is required for homodimerization.
Sequence:
MLDLTNKESESSDNGNSKYEDSIDGREVGTSKPFKEERSLEDLQADLADMAVWMEGLDATKLPLNDPQLLCNGRAFSEVLHNVDKNFFTDGWLETMPENRTTNIMVFRSCTRKLWRKMFDYVNHINRTVVSSRWTDIHERIDGIYESDLPAMVNLGMAVVTLAHIGKNAKRFVDYSKALTSTHKSMMSNVAKMVTTVIDEMPENPCFHEISELHGSQSELNSLSESSGKLNGNGSSERRSNADQILVDAELEIERLRTETENQRKEIERLTKSFETAQHDMSSNSESGDISILEKQNEELRQKRRELEEKNLELDAAVDQFKGIVFELTNENDVLRRSDKERQRLQTVLDAAQSDLDEWKTVANQYQKEAELSKQQDKEIKELLSQNKALKSRLDHHVKSATLEDANKNGIAQLRTQVGGLTALNTELKASLDSKKRCVEQLEIQLIQHKEKVKELEDRKDELIEERNRLENQLIFKEAVTPRSLHESMFEAGNLSFEPFSEKNTLPLEIENKRLTERIQELESLEPLKGELITLKSKNGVLEEEKLFATKQIEELQQQIEDLQENLLKNQEHASGDVVGLKIQLEKAEVEAQQMREAKMRAETNQAQVDEILKKRTAELEVNATALQKAKAVIDELEYNSRPVSEDSMTSVQAFKEMKEENEKLRQKVEKLEIELNTVTQGFEQENRLLTSASHQQVLNRSIDEVMSMRAHAGSEEPQTLLDTQKMSGALPWRSLASETRRELPTAMASILVLGFLVFIAWMFININSALNAPPNA
The following text describes a protein:
Function:
Gap class segmentation protein that controls development of head structures.
Subcellular Localization:
Nucleus.
Sequence:
MRTHRATMIDAFDTADFNPELILSSVFLDPGLDFVTNIDDLSDNSIAADLLQQLGNSIFYPETSIATNISNGGIAGLAETIPQQQHAQHQQQQHHNHQHQQQQQQQQQQQQVLLQPSMVSTKGRDTIEKPTDEMRFETFGSDYAKSQLTAAVPLTIPMVQQQQQQQQSAVAVQQQQQQTCKCEFCEYLQANRISLTGDHSFQCEFCGEGFSTQTSFNRHRCGSTDIQIYRCENCRQEYGSSRAMSTIGNCEPRDKCDICNRNIVQSLPEEQAAYGPSMAAGSSPMSSQTTASVLSDGTIGGTVHLPTMIATLTSPEVSNESVSDLSANVHVRSIVNSPIEQHDLSSLDPFGSDSECLGQFFAAEPSSTSPCTASSTATNLQCQPMPTSANMGSLLSIPALHQPESAKTYFVLGNVDQLQQFHDIAAPPPPATAEQAPVQQPPAGSNLPTAVTNSFHHLHLAPAGPGPHQQQQLLPLSLQNAAPATAGSLLLSEHEVTSLQQYDQYDDEDYSSMSEDEAIVPIEPYAKSPNQDHAKTELPIQETIVDTSTGISVMSLPPFGTGGLPRDADGSPLGRTLIPPPHGVGVQHHLQQHQQPLQQQQQHHHSSDVSLIHRDEEEEGKCDSSSSPLGLLVGSPSGIANGGGERRPHQAQSSTTTTTTSTSTNPDRPYKCHICDRSYRNQKNLRSHLKVHEGIRAYQCEICGKNFSGSSYLVIHRRRHTGERPFKCVTCGKAFVDSRALAVHARLHSGERLKCEKCEKTFSSVSALTVHNRLHTGIHPYRCELCGKTFPQYNNLKHHMKKHEQPSDAEQLLPQAMATSTGGPTPPSNGVSTTTSGSGTVLARISLSIQADTTGKGTVHMIASSTTGPASEYKCHICNKLYKSSDDLQEHLSQHSKDRPNQCEFCSKVFPRSSHLIIHRRRHTGERPFKCKYCDKAFVDSRALSVHTRLHTGERVKCEICEKTFASSSGLIVHRRIHTGVHPYKCDYCEKSFAQSTALKYHLKKHDTALLPTTTTPEGADTRLPALPQTGAADVGQCAPSFGEDATTNGNDRYKCTVCNKAFRSSEYLVRHRRTHSGERPYQCEICGKNFSTMSYLVIHRRRHTSERPYKCTSCEKAFVDSRALQEHARLHTGDRVRCEICQKTYSSVSNLIVHRRIHSGIHPFECDSCGKSFAQKNALKYHLKKHAETHKKQEQPEPVG
The following text describes a protein:
Function:
Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP).
Subcellular Localization:
Membrane; Single-pass membrane protein. Nucleus. Note=Localized primarily in plasma membrane or endoplasmic reticulum membrane as dormant form and, upon specific stress or signal, is processed into a transcriptionally active and nuclear form after a proteolytic cleavage through regulated intramembrane proteolysis (RIP).
Domain:
The NAC domain includes a DNA binding domain and a dimerization domain.
Sequence:
MEDQVGFGFRPNDEELVGHYLRNKIEGNTSRDVEVAISEVNICSYDPWNLRFQSKYKSRDAMWYFFSRRENNKGNRQSRTTVSGKWKLTGESVEVKDQWGFCSEGFRGKIGHKRVLVFLDGRYPDKTKSDWVIHEFHYDLLPEHQRTYVICRLEYKGDDADILSAYAIDPTPAFVPNMTSSAGSVVNQSRQRNSGSYNTYSEYDSANHGQQFNENSNIMQQQPLQGSFNPLLEYDFANHGGQWLSDYIDLQQQVPYLAPYENESEMIWKHVIEENFEFLVDERTSMQQHYSDHRPKKPVSGVLPDDSSDTETGSMIFEDTSSSTDSVGSSDEPGHTRIDDIPSLNIIEPLHNYKAQEQPKQQSKEKVISSQKSECEWKMAEDSIKIPPSTNTVKQSWIVLENAQWNYLKNMIIGVLLFISVISWIILVG
The following text describes a protein:
Function:
May participate in the regulatory network that controls the expression of MmpL lipid transporters. Binds to intragenic and/or promoter regions of rv1816, mmpL3, rv0204, mmpL11, mmpL7, kasA and mmpS3.
Subcellular Localization:
Cytoplasm.
Domain:
Contains an N-terminal DNA-binding domain and a C-terminal ligand-binding regulatory domain. The C-terminal regulatory domain can bind saturated fatty acids.
Sequence:
MCQTCRVGKRRDAREQIEAKIVELGRRQLLDHGAAGLSLRAIARNLGMVSSAVYRYVSSRDELLTLLLVDAYSDLADTVDRARDDTVADSWSDDVIAIARAVRGWAVTNPARWALLYGSPVPGYHAPPDRTAGVATRVVGAFFDAIAAGIATGDIRLTDDVAPQPMSSDFEKIRQEFGFPGDDRVVTKCFLLWAGVVGAISLEVFGQYGADMLTDPGVVFDAQTRLLVAVLAEH
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MAQLTVQIVTPDGLVYDHHASYVSVRTLDGEMGILPRHENMIAVLAVDEVKVKRIDDKDHVNWIAVNGGVIEIANDMITIVADSAERARDIDISRAERAKLRAERAIEEAQDKHLIDQERRAKIALQRAINRINVGNRL
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
Miscellaneous:
MISCELLANEOUS: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
Sequence:
MATTNFKGQPVKLIGEFIQVGKVAPDFELVKTDLSSFSLKDLNGKNVILNIFPSLDTSVCATSVRKFNKMGAGLKDTVVLAISKDLPFAHARFCTTEGIENVIPLSDFRFSDFDESYGLRMADGPLAGLLARAVVVIGKDGKVAYTELVPEITQEPDYDKALAAVKE
The following text describes a protein:
Function:
Forms a very stable complex with oxygen. The oxygen dissociation rate is 0.011 sec(-1).
Sequence:
MSTLYEKLGGTTAVDLAVDKFYERVLQDDRIKHFFADVDMAKQRAHQKAFLTYAFGGTDKYDGRYMREAHKELVENHGLNGEHFDAVAEDLLATLKEMGVPEDLIAEVAAVAGAPAHKRDVLNQ
The following text describes a protein:
Function:
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MTVLIHVLGSDIPHHNRTVLRFFNDALAATSEHAREFMVVGKDDGLSDSCPALSVQFFPGKKSLAEAVIAKAKANRQQRFFFHGQFNPTLWLALLSGGIKPSQFFWHIWGADLYELSSGLRYKLFYPLRRLAQKRVGCVFATRGDLSFFAKTHPKVRGELLFFPTRMDPSLNTMANDRQREGKMTILVGNSGDRSNEHIAALRAVHQQFGDTVKVVVPMGYPPNNEAYIEEVRQAGLELFSEENLQILSEKLEFDAYLALLRQCDLGYFIFARQQGIGTLCLLIQAGIPCVLNRENPFWQDMTEQHLPVLFTTDDLNEDIVREAQRQLASVDKNTIAFFSPNYLQGWQRALAIAAREVA
The following text describes a protein:
Function:
Probable regulator of exocrine pancreas development.
Sequence:
MAAIPSSGSLIATHDYYRRRIGSTSSNSSCSSSEYTGEVIPHPPGLARQDSGHWWSSFFFGKQNQMGTPNGFESQQKTGTYTVTNGQVTCVAREIVMKRHLSESSDSGKEPGSPLPS