lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact. Also displays peroxidase activity on guaiacol in vitro.
Subcellular Localization:
Periplasm.
Sequence:
MQYKDENGVNEPSRRRLLKVIGALALAGSCPVAHAQKTQSAPGTLSPDARNEKQPFYGEHQAGILTPQQAAMMLVAFDVLASDKADLERLFRLLTQRFAFLTQGGAAPETPNPRLPPLDSGILGGYIAPDNLTITLSVGHSLFDERFGLAPQMPKKLQKMTRFPNDSLDAALCHGDVLLQICANTQDTVIHALRDIIKHTPDLLSVRWKREGFISDHAARSKGKETPINLLGFKDGTANPDSQNDKLMQKVVWVTADQQEPAWTIGGSYQAVRLIQFRVEFWDRTPLKEQQTIFGRDKQTGAPLGMQHEHDVPDYASDPEGKVIALDSHIRLANPRTAESESSLMLRRGYSYSLGVTNSGQLDMGLLFVCYQHDLEKGFLTVQKRLNGEALEEYVKPIGGGYFFALPGVKDANDYFGSALLRV
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MEMVCESGTCRPYRSAGDAGHLPVNKWTSADMSAIHQSCLLKQLDQQRKQELFCDCSVLVEGQIFHAHRNVLYGSSGYFRMLLTQGAKDTVDSVSASFDVFSPDIFTIILDFIYSGQLELNSSNVIEVMSAASYLQMNDVISYCKAFIKSFLEISTKEDDENRYLCLSENSSLQDRRESTIEPSNMCDVSMSSQSRLWDEEQEDDQPQEDFGGTSPQPSGLQHNSPAQSSLEEQYSSVLPERRRRGSRKRTASSRLVAEDTSLIDLQGVVSHCSQKADELYANLPSIVGVVGMFNKDATPSMRYKCPFCTHTVKRKADLKRHLRCHTGERPYPCQACSKRFTRLEHLRSHFETIHQARKLVCRKCKRHVTEVSGRVVSEGTRKYRLCDVCIQESGYNDLITDETDGNEDKEGLLLGVDEDMSENRQITWVMDDDDLAEDSGADLIIQEVDDSDEEASGK
The following text describes a protein:
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MYCLLALRTYSVYISTEIAFSGFIICCYNWLIMVASIGDTVYGDEQSSFKCNTLQPGCENVCYNHFAPISQIRFWAVQILFVGTPSIMFIIYAMHRMTTIPPSHAKSSSDGADDESEKPKKIETASSSTSSSKAGLPGYDEIMHNGSRVGKGKNGKLLKKVEEATINQKWNKFDGSRSEVIYVNRPQTKETQRKSPAKKSHQAKRKAVYQQDGKTEIVKTPGIVRAYVVQAFLRTAIEAVFLYLQYDMYKFDVPELYVCNGFPCPRTVECFVSRPMEKTLFLRFMYAMTIVSLLLNLIEIYQLISKWVRRSCCRSGNSNAVSLDDRLPMEEVVIQSGEDGAIFRRARMQNTFPDLGPIPRSYDNSLGESSGDESMDSDYRFYGR
The following text describes a protein:
Function:
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes; Regulates also the sphingolipid metabolism.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MPVCIHCATPIESLYMRYGKDHIVLSPCSSSICSPTPACTSTCSTSPSDTATATGPAAGSASAAILADEYLEHDLPIVIIDLLLAKSQAYRHLLFNRSSIFNPTPDQAAKTTGQAPKKLKWGHVFAVLKRFVALCLVDAYIRWFYLCVHPSLPPAGGAELTKNRAANVMERMQRWVPMQAGMFFASVFTARSEHAEREMGAVGVVCSAAPLWLSNSASVRLAMSSDVMVPTLISYINVLMLTIIEASVLHFCVALLTHLTIRYLLSTQSPTSSKPTKSSAKPPLALDSHLADPLLPTQALLLSQLSPLILLLFVLLWNTKFPRPTTPTWSTSSDTSAFSKRRIVWIIRTFLASLNAGVALATCLPSTAAHKRKTCIHTLAPAAILAAAWSAQALISAWLYTCLE
The following text describes a protein:
Function:
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons (By similarity). Involved in neuronal activity in the auditory system.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MASCWRLILFLSVTRWLSDYSEALSGLSTSYAALLRIKKSSTSPFGSKSRPRFSSPSLGTISVSPPSWRGAAQQYHSPGNLYHSSDAFRQDESVDYGPVFVQEPDDVIFPTDSDEKKVALNCEVRGNPSPSYRWLRNGTEIALESDYRYSLIDGTFIISNPSELRDSGLYQCLATNSFGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNAVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKSRLRKSQAVLEIPNLQLDDAGIYECTAENSRGKNSFRGQLQIFTYPHWVQKLNDTQLDSGSPLQWECKATGKPRPTYRWLKNGAPLLPQSRVDTVNGILAIQSVNQSDAGMYQCLAENKYGAIYASAELKILASPPSFELNQVKKSIIVTKDRGVLIECEPQGSPKPAISWRKGDKAVRANKRIAILPDGSLRILNASKADEGKYICQGVNIFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEKEGGHFENIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGVVIVEEITESTATLSWSPATDNHSPISSYNLQARSPFSLGWQTVKTVPEVITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSIPSRMIRTNEAVPKTAPSNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPTAAPTDVTATSVSVSEIFVVWKHVKESLGRPQGFEISYWKDTEPEDSVETVRTRGNESFVMLTGLEGNTLYHLTVRAYNGAGYGPPSREASTTTKRHPPREPPGNLRWEQQGSQVSLGWEPVRPLANESEVMGYKVFYRQEGHSEGQVIETQKPQAVVPLPEAGVYIIEVRAYSEGGDGTASSQIRVPSYSGGKITSAQSTLHSLSKWSSVTLLLALMLPSSSW
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDTFYPNVLWAQRKETISLKVEIGKADAPNIKLSETSLDFEAQGTGATGEKYYKFHLDFFLPIDPEGCVYKISPHSVEIQITKAGVGKWWPRLVPVDQKKPHFLKLNFDKWSTESDEEEQKAAVRANTVNNEVKDSSNHKKTAGNVYLLTYNGIQFMFFSLILFTCLTGRLRSGSEVCATTYDTIGWLVIFSVILSYVEAVHPLLGLVKSSWIQPFIQVSGRCFALLCLWLAEPTAKDGCSVSNLFIAWSLAEVIRYPTYTAQILGIEFKALSWLRYHAWIILYPFGGYSEFEVISAAANYLDEKNIYKLTLPNMFNFSFKLSSFMRLYTAVLVIGVLVLMRHMWKMRQRKFGKRMKYKPA
The following text describes a protein:
Function:
Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications.
Subcellular Localization:
Cytoplasmic vesicle, COPI-coated vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MERGTMWRLQCLMKELRWWSFLSFMLFSFGCVRASELTFELPDNAKQCFYEDITQGTKCTLEFQVITGGHYDVDCRLEDPDGNVLYKEMKKQYDSFTFTATRNGTYKFCFSNEFSTFTHKTVYFDFQVGDDPPLFPNENRATALTQMESSCVSIHEALKSVIDYQTHFRLREAQGRSRAEDLNSRVAYWSVGEAIILLVVSIGQVFLLKSFFSDKRTTTTRVGS
The following text describes a protein:
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MNNVYYIGFSIAMIWLPRRIDRSLYEQQATAWHGRLSYVAPLFTSPDTAKRKRVYAPVRLTLSPHLCTITETTTKLHRASMVNERPRQFSGVSRFAGPSRPGVPHPSSSATASLSGTPNQSRAKVLGLGLGKGSGGLGKGKGKGLKRHMKIQRDTIYGVTKGDIRRLARRGGVKRIAATIYDDIRQALNDRLRSILKDAIAVVECSGRKTISVTDIIFVLNRQGRQLYGFDPSFNGVR
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity (By similarity).
Sequence:
MADFYYLPGSSPCRSVIMTAKAVGVELNKKLLNLQAGEHLKPEFLKINPQHTIPTLVDNGFALWESRAIQVYLVEKYGKTDSLYPKCPKKRAVINQRLYFDMGTLYQSFANYYYPQVFAKAPADPEAFKKIESAFEFLNTFLEGQEYAAGDSLTVADIALVASVSTFEVAGFEISKYANVNKWYENAKKVTPGWEENWAGCLEFKKYFE
The following text describes a protein:
Function:
May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6; [Isoform 3]: May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation (By similarity). Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (By similarity).
Subcellular Localization:
Cytoplasm; [Isoform 3]: Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MTEGVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGWASSQKGARHRTSKTSGAQCPPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPPHVAAGWSPDPKYQICLCFGEEDPGPTQHPKEQLIMADVQVQLRPGSSSCTLSASTERPDGSSTPGNPDGITHLQCSCLHPKRAASSSCTR
The following text describes a protein:
Function:
Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MAEKSCVKRLQKEYRALCKEPVSHVVARPSPSDILEWHYVLEGSEGTPFAGGYYYGKIKFPPEYPYKPPGITMITPNGRFMTQKKICLSMSDFHPESWNPMWSVSSILTGLLSFMMDNSPTTGSVNTTAAEKQRLAKTSLSFNCKNPTFRKLFPEYVDKYNKQQQLISEHSSPESPQGENSKPKTEKLVGSSGEDVKKVIPRRKQPFPTWMMFLLVSVFGIVMALPLLQL
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MTHQLHQYHLVDPSPWPLTGAMGSLLLASGLAVWFHTNNTMLLKFGLLTLLLTMFQWWRDIIRESTYQGHHTSGVQKNMRYGMILFITSEVFFFLGFFWALYHVSLVPTPELGAEWPPIGITPLNPMEVPLLNTAVLLSSGATITWSHHTMMKGNKKEATHALMLTIILGAYFTALQLSEYMETPFTIADSVYGSLFFVATGFHGLHVMIGTSFLMVCALRLAKHHFTITHHFGYEAAIWYWHFVDIVWLFLYISVYWWGS
The following text describes a protein:
Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MVTNRVDVFWHEGMLRHDAVEGVFDTGYDPGFLDVLEKHPENADRVRNMLSILRRGPIAPHVNWFTGLPAIVSELLMFHTSEYIEKLVEADKSGERCEIAAGTFMSPGSWEAALLAAGTTLSAMQHILDCHGKIAYALVRPPGHHSQPTQADGYCFLNNAALAVKLALNSGSCSRVAVIDIDVHYGNGTAEGFYTSDKVLTVSLHMNHGSWGSSHPQKGSIDELGEDVGLGYNLNVPLPNGTGDRGYEYAMNELVVPAVRRFGPDMVVLVVGQDSSAFDPNGRQSLTMNGYRRIGQIMRGVAEEHSHGRLLMVQEGGYHVTYAAYCLHAMLEGVLKIPEPHLSDPIAYYPEEEANAVAAVESIKTYHTEFVPFLRGT
The following text describes a protein:
Function:
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
Subcellular Localization:
Nucleus.
Sequence:
MELNNYRNSTNNDSSRRSVVFLGSPLTDITANVDREFLRKYNLEPDNAYVVDETRRPIFDEIGETAIQVGGSVTNTVRMFTKLRGFPELVTYLGSVGLDEKGKFVKTELEKEGLGRDLTEIAGGSTGKVAVLVWGTTRTLVTDLGASRTFSLDEDKWAKITRSSFVYFSGFFISVSFPSLVRIVEQTDKTICFNLGAPFLCSKYPQEMTYLYKNASLVVGNESEHRAFAKINNLESHDLLEVVMATNKSFPKSRVVIVTRGGGTVVVVTANGWQEFAVGSLSDEKIVDTSGAGDAFIGGFLAGWVDDATVADCAKSGILAARRVIQTVGFNL
The following text describes a protein:
Function:
Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTRAQQTISIALLVSSLYLSLYLELVPLPALVQTAIVPVLPFWALVSFGAWVLFRLGWGMLTFRDTPEAYKELMEEIKLAQADLRAKGVSVD
The following text describes a protein:
Function:
Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.
Sequence:
MQIINDTSAMIPEPCVATIGFFDGVHMGHRYLIQQVKEIAAAKGLRSALVTFPVHPRKVMNAAYHPELLTTPEEKTNLLAGTGVDYCLMLDFTPDISRLTAKEFMTQILKERFQVKYLVIGYDHRFGHNRSEGFDDYVRYGQAIGIEVIRAQAYTDDIQIDTIQSAPVSSSLIRKLLHQGDVDAAARCLGYEYFLDGTVVGGYQVGRKIGFPTANLSVDDPDKLIPADGVYAVWVTFDGKTYMGMLNIGVRPTIGNGPNRTIEVNILHFHSDIYDKFIRLTFVKRTRPELKYDSIDELIAQLHKDAEETEAILLAAKQEK
The following text describes a protein:
Function:
Histone methyltransferase.
Subcellular Localization:
Nucleus.
Sequence:
MIVKKSLKSVMPILKRCRLGRSAGDDEDSSVHRKKRKISNGYYPMHLLGEAAAGIIPFNGYGIQKILSNSAASMEVRGGRERIAASEPRTANSKVKEVSRPPLVKTSRGRVQVLPSRFNDSILDNWKKEKDISTNEERDSAPDTEYIPVKGKDNKLGSKTLRIHGDGSINRKRSEGKTNSSQCRKFSPLSEDEIAELRNNELRISDSRKYDEELEEFIKVSGIDKLYSTKDFVEGEIVWAKSGKHCPAWPAIVLNQESQVPQQVFNFRLAGTVCVMFFGYSGNGTQRDYAWIKSGMIFPFVDYVDSFQGQTELNDSKPVDLRSAIEEAFLAENGFNEMLMVEINAAAGNMDYFHSLKRGAVFEVSDSNQDKNCDSIEQDVHMKQESRSCEACGVSIAPRLSRKSHNSAAGINRLCTSCARLKKMKHYCGICKKIRNQSDNGTWVRCNGCKVWVHAECDKFSKSKFKDLRASDYYCPECKARFNFELSDSENLQAKTKNNKKNGKHTLPDKVAVVCSGVEGIYFPSLHLVICKCGYCGMEKQALSEWERHTGSKTRNWKSSVRVKGSLIPLEQWMLQMAEYHERSLVPAKSVKRPSIKVRKQKLLTFLQEPYEPVSAKWTTERCAVCRWVEDWDFNKIIICIRCQIAVHQECYGARNVRDFTSWVCRACETPDIERECCLCPVKGGALKPTDVAPLWVHVTCAWFQPQVSFASDEKMEPALGILRIPSSSFVKICVVCKQIHGSCTQCSKCSTYYHAVCASRAGYRMELHCLEKNGKQMTKMVSYCAYHRAPDPDNVLIIETPKGTFSAKSLLQSKRHTGARLISTSRLKIEEPPLEDNEEADPFSAARCRVFKRTKKVYGEGKRTNNYAKKEAVAHQIMGPQRHSMSAILKLNANRKMEKPCTFSTFRERLQHLQKTEKDKVCFGRSEIHGWGLFARRNIPEGEMVVEYRGEQVRRSVADLREARYRAAGKDCYLFKISEEVVVDATDAGNIARLINHSCMPNCYARIMSVGDDESRIVLIAKTNVLAGDELTYDYLFDPNEPDEFKVPCMCNAPNCRKFMN
The following text describes a protein:
Function:
Part of the ABC transporter complex FecBCDE involved in citrate-dependent Fe(3+) uptake. Probably responsible for the translocation of the substrate across the membrane (Probable).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTAIKHPVLLWGLPVAALIIIFWLSLFCYSAIPVSGADATRALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGTLLQTLTHNPMASPSLLGINSGAALAMALTSALSPTPIAGYSLSFIAACGGGVSWLLVMTAGGGFRHTHDRNKLILAGIALSAFCMGLTRITLLLAEDHAYGIFYWLAGGVSHARWQDVWQLLPVVVTAVPVVLLLANQLNLLNLSDSTAHTLGVNLTRLRLVINMLVLLLVGACVSVAGPVAFIGLLVPHLARFWAGFDQRNVLPVSMLLGATLMLLADVLARALAFPGDLPAGAVLALIGSPCFVWLVRRRG
The following text describes a protein:
Function:
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
Folds into a two seven-bladed beta-propeller structure which is required for elongator complex assembly.
Sequence:
MFQYEALHVGCNRIPTAATWSSNLGLIYGAERLIAVADPFKEINYLMAGHSGRINCVCELATNSEYRSPFILSGASDKTLRLWQLEEEYFTCIKTIELEATVNCLCVNENLVVCGCSNSSCIVYSWNAEQRNLTEISRFTCSEIIPLEFAIVKLDHGIILTVCGSSKKIMVYGSDSAISSFKLKAVLRGHLDWVRTLSFKKTSGSTATLASGSQDRYIRLWNISLWGSEDEKVSEEFFESVLSNKPVRFTLGKIDLKIVFDALLMGHEDWVMSVDWHPTKEMILSSSADSSMIVWEPDTNTGIWVVTGRMGEMASSHGSTTATGSAGGFWGGLWNPNGNCVVCWGRTGGWRLWKQDAGQWLQLPSISGHTKSVKGVAWDPEGKFYLSAGTDQTTRLFARFKKDNAWHEMARPQIHGYDLTSISCMPSRIGFLSCADEKVSRVFKFPKTIVRLLYRLCDTNIGEESLPDAANVPLLGLSNKATTASETGTVNAEEVQTPVADVIGSLNHPPFEEHLQRLLLFPEVEKLFGHGYEVYACAISNNGNIAATSCKSQTPEHAVIRLYETQSWNQQQVLKGHSLTVTTIKFSPDDRYILSAGRDRLVCLHEQAENLLDYNNFASIKAHSRIIWDASWAPKEMGYFFATASRDKFVKFWKINDNKKICDVAALQFSDAVTAVDFAPFFHNDELLLAVGTEAGKIFIWRCPRENLTKWYPTRLPDHMAPMESINQILWKPTFETMGLYSLLIAGEDTSVRLLNVTLG
The following text describes a protein:
Function:
Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Involved in rDNA silencing.
Miscellaneous:
MISCELLANEOUS: Present with 1390 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus. Chromosome, centromere. Note=Transiently released from the nucleolus and localized to the centromere regions during late pachytene. This relocation is CDC5 dependent.
Sequence:
MTTLLQLLSNYYKAKLDSERIYNEYVQSQYEFASLDKLNNNKGDPKKVVDETLFLQRQIAQLNKQLQLSFQENEKLLSVQKNQKALYQSKLSSKDAFIDDLKLKLKVEQISVDKHNKERTPSTGRDEQQRNSKAAHTSKPTIHLLSPIVNRDKPNNQTNDRGGNDPDSPTSQRRSRGLRSLLSSGKNTIFDSISKNLDDEINENAHIRNDTTSSKIAGKSPSRLSALQKSPELRKERNNMILKEHILRSKDDQNITSSRKLDNIELSSIGDSTAMTSRSSTVNANDILGNEENDGITKLKRVNKLTSSPVKRDCSTNKKRKLTKQRIATLPNSDEELSNNLNVDEFV
The following text describes a protein:
Function:
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at the P1 position.
Subcellular Localization:
Mitochondrion. Cytoplasm. Note=Mainly mitochondrial.
Sequence:
MNNICKLNKFIISKSSSSLSSTSSKIKTNCLIKNAKMFSSSLNLNRFYSTNNTNNNKLKKPLSIGQATFETHPYLLDKNEITKGIKMKEFKDRREKLMKNFPIGSVVVIFTPPEPMMSYDIPWSFRQNTNFNYLTGFNEPEAVLVLVKTSELDHQSYLFVRERNEEKEKWDGARCGGENVKKYFGIDFGYNLTNRDIPILGKLLKSTTDGKLYCNTTPWNQLSNKLEPFLENIKFYTVESLLQQIRLIKSDAEIKMMLKSGEIAGTSFHETMKYTGTKSSSSSSSSSSSPLNEYQVSAYFEWCVKDKGAQRMSYPPVVAGGDNGHTLHYIQNNQLLNYCDLLLMDAGCEYWGYTSDITRTFPVSGKFTEAQSEVYQAVLDVNKKCIELCKPGETINSIHLKSVELIQAHLKRLGIINESNPNDYRLYYPHSIGHYLGMDTHDTLDFDYGVTLEPGMIITIEPGIYISKYDSNVPEKYRGISIRVEDDVVIPNLNNSPLVLTHLAPKEISEIESIMSNK
The following text describes a protein:
Function:
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
Sequence:
MALERSDVEKIAHLARLGLSEADLPRTTETLNNILGLIDQMQAVDTSGVEPLAHPLEATQRLRPDAVTETDHRDAYQTIAPAVEEGLYLVPKVIES
The following text describes a protein:
Function:
Has a dual specificity toward Ser/Thr and Tyr-containing proteins.
Sequence:
MVNLEELSLKRNNMKRTETTFTDISGKRYQVANINEENSESNRIELNRTSGFVIDTKPDDLSHKIEIIIPQSILNNNNNNYESINLYIGSQDAAFNKLDLQLKNIKSILNVGIGINNLFTKENSDINDGFIINYCNVEIFDDVNFNIIEKFDKCFEFIDSNIGGVENNGILVHCNAGVSRSATILISYLMKKLKIPLSLSLEILKSSRPQCKPNQGFLKQLEIFEKELLF
The following text describes a protein:
Function:
Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity. Independently of subunit beta, HADHA also exhibits a cardiolipin acyltransferase activity that participates in cardiolipin remodeling; cardiolipin is a major mitochondrial membrane phospholipid. HADHA may act downstream of Tafazzin/TAZ, that remodels monolysocardiolipin (MLCL) to a cardiolipin intermediate, and then HADHA may continue to remodel this species into mature tetralinoleoyl-cardiolipin. Has also been proposed to act directly on MLCL; capable of acylating MLCL using different acyl-CoA substrates, with highest activity for oleoyl-CoA.
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane. Note=Protein stability and association with mitochondrion inner membrane do not require HADHB.
Sequence:
MVASRAIGSLRRFTASQTLRCPGYICRNFTRSSALLTRTHINYGVKGDVAVIRINSPNSKVNTLGQELHSEFIEVMNEVWSSSQIRSAVLISSKPGCFIAGADINMLSACTTSQEVTQISQEAQRTFEKLEKSTKPIVAAINGTCLGGGLELAISCQYRIATKDKKTVLGAPEVLLGILPGAGGTQRLPKMVGVPAAFDMMLTGRGIRADKAKKMGLVDQLVEPLGPGLKPPEERTIEYLEEVAVTFAKGLADKKISPKRDKGLVEKLTSYAMSIPFVRQQIYKKVEEKVRKQTKGLYPAPLKIIDVVKTGIEQGSDAGYLSESQKFGELAMTKESKALMGLYRGQTLCKKNKFGAPQKEVKHLAILGAGLMGAGIAQVSVDKHLKTILKDASLPALGRGQQQVFKGLNDKVRKKALTSFERDSLFSNLTGQLDYQGFEKADMVIEAVFEELSLKHKVLKEVEAVIPDHCVFASNTSALPISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDSTASAVEVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVLRILQEGVGPKKLDSLTTSFGFPVGAATLMDEVGMDVAKHVAENLGKIFGERFAGGNLDVLKQMISKGFLGRKSGKGFYVYQEGVKNRNVNSDTESILASLKIPSRPDISSDEDIQYRLVTRFVNEAVLCLQEGILATPAEGDIGAVFGLGFPPCLGGPFRFVDLYGAQKVVDRLRKYEAIYGKQFTPCQLLIDHASSPNKKFFQ
The following text describes a protein:
Function:
Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by lrrc33/nrros is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by lrrc33/nrros.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MPVCGCLSVVLSHAVVLLMLVLHSASGHPQTFPCRLIQRVALCSGRQLSVIPDCLPHETEEIFFDRNLLENLQDGLSRYPFLRMFSCANNQLMTVAETAFIESHLLENLNLANNELHHGHKQVAQAFRSLTQLKTLDLSGNGLSEDMVSVLVANLSSLESLYLSRNGMQRLDESTFRDLHQLKELNVERNLLFEISGAFDHMKKLQRLNLAFNCLPCLVNFEMTQLLVLNASHNSIEWFITNQNLTETFQLETLDLSDNHLLFFPFLPTNNQIRTLLLSNNRVGFYQHLANSTSSNWTTSVDYYNLGQNISNITMDLWNENLHGNLSSVEFLDLSENKVNYFPQGFIKQMPQLYWLKLRSNCLQSFSLTSEDLPVTIYELDVSRNRLTEIKASQTSKNKLNNLTHLNLSTNDLQNFPPMIFTSLPNLNTLDLSHNTVDVCYSSNYMGLSGCVEWSSMASLKQLYLADCSIQNVPSSAFKGTSLTHLELSNNPNLHLKQQSLKGLANTLQHLGIGNTGLQDFDFSPYTNLKSLNISRNSLSKLPDSLMALNLKLLDLRDNSLTTIKSEHASLLAKKLQTVYMNGNAFNCCHLDWFRTFGENKGIHVADLSEITCLDLNYRRHKVVLTDAVYCGFTNNNKESVVWYILLFVTVSVSIMGISVIYMLTFKPRMLPRVIKKKCWRPTSY