lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Member of the two-component regulatory system FleS/FleR that regulates the expression of multiple genes involved in flagellar synthesis, adhesion, swarming, motility and antibiotic resistance. May function as a membrane-associated protein kinase that phosphorylates FleR in response to environmental signals leading to activation of specific gene promoters (Probable).
Sequence:
MQPALNAFTEQPADTAEATSRAGLEQAFALFNQMSSQLSESYSLLEERVTELKGQLALVSAQRMEELAEKERLANRLQSLLDLLPGGVIVIDAHGVVREANPAALGLLGEPLVGMLWREVIARCFAPREDDGHEISLRDGRRLSIATRSLNGEPGQLILLNDLTDTRRLQEQLARHERLSALGRMVASLAHQIRTPLSAALLYAGHLSEQALPTDQQQRFAGRLKERLHELEHQVRDMLVFARGELPLTDRVAPKALFDSLRAAAEVHVQGLQVRWQCEARGGELLCNRDTLVGTVLNLVENAIQACGPELRLKVHLYARADSLRLSVSDNGPGMDPATLARLGEPFFTTKTTGTGLGLAVVKAVARAHQGQLQLRSRPGRGTCATLILPLIPAAPLSAIQE
The following text describes a protein:
Function:
Essential for the maintenance of cell size and integrity in response to osmotic stress.
Miscellaneous:
MISCELLANEOUS: Present with 189 molecules/cell in log phase SD medium.
Sequence:
MGNSGSKQHTKHNSKKDDHDGDRKKTLDLPPLTKSDTTHSLKSSRSLRSLRSKRSEASLASNVQAQTQPLSRRSSTLGNGNRNHRRSNNAPITPPNNHYLTSHPSSSRRLSSSSRRSSMGNNNNSELPPSMIQMEPKSPILKNSTSMHSTSSFNSYENALTDDDDDRGDDGGESPSMAKVTRINTSSSADRGSKRTPLRRHNSLQPEKGVTGFSSTSSKLRRRSDNTLPASYPLNAEAGGNGSDYFSNRSNSHASSRKSSFGSTGNTAYSTPLHSPALRKMSSRDNDDSGDNVNGRGTSPIPNLNIDKPSPSASSASKREYLSAYPTLAHRDSSSSLSPRGKGQRSSSSSSSSQRIYVSPPSPTGDFVHGSCADGDNGSRTNTMVEMKRKKPVRPVDIDEIIQRLLDAGYAAKRTKNVCLKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLLWSDPTDSSNEWEDNERGVSFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELLDPLDSTALKQVMKKGRQERKLANR
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of an unusually broad range of substrate including deoxyribo- and ribonucleoside tri-, di-, and monophosphates, as well as polyphosphate and glucose-1-P (Glu1P).
Sequence:
MTIKNVICDIDGVLMHDNVAVPGAAEFLTGILEKGLPLVLLTNYPSQTGQDLANRFATAGVNVPDSVFYTSAMATADFLRRQEGKKAYVVGEGALIHELYKAGFTITDVNPDFVIVGETRSYNWDMMHKAAFFVANGARFIATNPDTHGRGFYPACGALCAGIEKISGRKPFYVGKPSPWIIRAALNKMQAHSEETVIVGDNLRTDILAGFQAGLETILVLSGVSTINDIDSMPFRPSWIYPSVAEIDVI
The following text describes a protein:
Function:
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
TSLPASAKWYDRRDYVFIEFCVEDSKDDNVNFEKSKLTFRCLGGSDNFKHLNGIDLFHCIDPNDSKHERTDRSILCCLQKGESGQSWPSVDFNNWEDWEDDSDEDMSNFDRFSEMMNNMGGEEDVDLPEVDGADDDSQDSDDEKMPDLE
The following text describes a protein:
Function:
Catalyzes the reduction of fumarate with reduced coenzyme M (CoM-S-H) and coenzyme B (CoB-S-H). In vitro, is able to reduces fumarate with reduced benzyl viologen, oxidize CoM-S-H and CoB-S-H to CoM-S-S-CoB with methylene blue, and reduce CoM-S-S-CoB with reduced benzyl viologen. The enzyme has specificity for the two thiol compounds as the CoB--CoM heterodisulfide reductase. The enzyme is very sensitive to oxygen.
Subcellular Localization:
Cytoplasm.
Sequence:
MINVKVLRFEPGVDEKPHLESYDIPSKEKMKVLDALQLINKMYNANIAFRSSCRAGQCGSCAVKMNGEVVLACRAEVEDGAVIEPVDLPVIKDLMVDRSEIEDKVRAMGLYLQSEARGIQRIKPEDYQDTKKLRGCIECFSCISSCPVIKESTEYAGPYFMRYISKFAFDPRDEAERAAGGVEEGLYCCTTCGKCAEVCPKELNVPGDAIEKLRAMACREGAGPLDAHRKIKKLISETGRSVDHIGKGFIESVGQNPGSRIGFFTGCLVDYRMPDVGMALLRVLREHGFEVDVPDGQVCCGSPMIRTGQLDIVEDLVERNRRALEGYDTIITVCAGCGATLKKDYPRYGVELNVLDISEFLADRIDDIKMKPVNMRVTYHDPCHLLRGQGVKLEPRKILNSIPGLEFVEMEKQGQCCGSGGGVKSGKPEIAESLGKKKAEMIRKLNVDAVITICPFCQLHIKDSLEKEGLGDVKVMNILELLDMAYSDD
The following text describes a protein:
Function:
Component of the ESCRT-II complex, which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin plays a central role in endosomal sorting of ubiquitinated cargo proteins by the ESCRT complexes (By similarity). Required for vacuolar sorting of carboxypeptidase S (CPS).
Subcellular Localization:
Cytoplasm. Golgi apparatus.
Domain:
The second RanBP2-type zinc-finger is functional and binds ubiquitin.
Sequence:
MAFYLETTPSNLPVLDPSEEILLVQDQVGLYFGDEKSFRHNNGTLYLTKKHIFYVDSVDPKKNSLKIKISDIRDVQHTSRYFRSSPKIRLSLRHVEKSWACKICTFINVGDPINPCRNCGVANRFTIIKPKSDARFSQGLCTACTFQNYPDLNTCEICGNQLKNVDRNQLIQLSFRGSGSSKFYEAIKSETDEIEKQRYSNKYDTKVLRKAILEKSLRMGGIHDLEQSHEMQLAKNGRTLVHAFQDLDAFFSLAKDTMSLADQFAEKMDGLTGTQQSDKVQQLLNKSNQLGVLRGNHLDNVPVSANSRLYDIELCKSISEVLRTRLKADTDTVTMTQAWAIYNRSRKANLIPPTRFVKACELIDSMEVGITTSKMNSGLILFQLKTSNHSGKLLSAILEVMNPSTTALKCAMRLHWSIGVTLERLYQAEMDGYIVRDVYEESGSSLLYWKNEFDELSEELTKWFDES
The following text describes a protein:
Function:
Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity).
Subcellular Localization:
Nucleus membrane; Multi-pass membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MADSVKTFLQDLGRGIKDSIWGICTISKLDARIQQKREEQRRRRASSLLAQRRPQSVERKQESEPRIVSRIFQCCAWNGGVFWFSLLLFYRVFIPVLQSVTARIIGDPSLHGDVWSWLEFFLTSIFSALWVLPLFVLSKVVNAIWFQDIADLAFEVSGRKPHPFPSVSKIIADMLFNLLLQALFLIQGMFVSLFPIHLVGQLVSLLHMSLLYSLYCFEYRWFNKGIEMHQRLSNIERNWPYYFGFGLPLAFLTAMQSSYIISGCLFSILFPLFIISANEAKTPGKAYLFQLRLFSLVVFLSNRLFHKTVYLQSALSSSSSAEKFPSPHPSPAKLKAAAGH
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MLLATALLLPLALAITPPPQTFVNTAIARTVELGGATAQVTTQYNIKATVDEPGEYHLALSGDGDEIPAWWEVAIGGKAVEGVRIIDDSPPTVSVPLGHLKNGDTTTLSLTHVLTHMSKPLPAEIDQREAQYLLFTTNSTYVDSWYPTDVERVKYRAPHIILSHTSVPDTYTHDSTVTKAGSSLTLGPFHSLPATLNKHEFEQQPLSVHYESKQPVIGLKSLKRSAEVSHWGANLNIQDEMSLVNAGPRLKGHFSRLAHQQSRFHASTPPQVLTELPLRIPATAHSAYYYDTIGNVSTSHFRPGSILTQKVKTSKARTSPKTVDGLLELRPRYPLLGGWNYSFVVGYDMPLEDVLKSDQANGKNVLAVPFMTGIKDVVVDDAELKIILPEGAKDVEVYTPFAVDSIEHSIHKTYLDTTGRYAVTLRKARCTEDHAKTVYVTYSYPFSALMQKPLTVASVVGGLFLLAMGLRRVNYSIDKQ
The following text describes a protein:
Function:
GTPase-activating protein (GAP) for RHO1 and RHO2. Involved in the control of cellular morphogenesis. Required for proper bud site selection and bud emergence.
Miscellaneous:
MISCELLANEOUS: Present with 1230 molecules/cell in log phase SD medium.
Sequence:
MKGLLWSKNRKSSTASASSSSTSTSHKTTTASTASSSSPSSSSQTIRNSTSGASPYMHSHHHHGQGHSHHRGEDNNRDKRKSSVFPPSKQYTSTSSSQVNLGMYHSDTNTRSSRSIASTLKDDSPSVCSEDEISNSSSQKSNAQDETPIAYKKSAHSKDSLLPSRSSSLSPPQSRCSTGTTLEKSLNTSGISNSSGTNNNNSNNNNDNEQKQRNVIHLNSENYDTTVFKTGWVNKSHGQTVATNYNSSMTAPSSSSSSSSQNLRNDAYSRNRESRFYGNDGSSLKNDDSSSTTATNSGNDVASARSSMAIDPQMLVPDYRLYRAQLKGCVLNLYKSGLNSNIKFFDPTLPASNSSIANENHQQKKQQTNNQAQAEALHQKQSFGQMGEPITLDLKYLSEVYPHPDLRQDSDGKIISGTIESLCHTVLFYPGPKQSDVPNEKSLSKTHRAVINLLLMFPLLDHFIKFLKVFNQFGLSFTKNKSRLTNNSTQFYNISPAVDDSMTQRLALTAKTILDVFPGFLLDEPMLKTIISLLDTISLHNDEISNNLKIKIANKHNELMKLTAFTRSLPMATSSTHELEIILDPSHFLSLDITTLADEVHHINLKFDKVWAPKFDYSLLYDSKFINRRIVSLNPLVFNNDQNIHFLGRLLISHLFPTNPEFSKKVTPKVRAELLDKWVQIGCRFEHLGDMVSWLAVATIICSIPVLRSSSWKYVPDQSLKTIFKDWVPTIIQLERRQRTSKSTSSVFILAPPNLDDDFTRANVISYFGDLLIHADDLPSDTKFKYLEKKINRTKNAFHKWQQRLQAIDSTRHKTNSTENVRDNDSPNNVVYQLWKFHLSQPPLNIEGIMKLSVQHEPPIIDQKAYSTIGSQRSALVTGSYLPILFNELFPNYSLFPKNTLVGAASDAKLPPPRSSARLSKSLSISEPIPIASNSHTMGSLTDDAMSSKNDNNKVTGVGKIDGPVIKEMSSKQSNKQRLLKSVRDVFNIDMDVFHISDELVFKSVYDNDGKSRPASMVIETPKRFSQHSSMLINNPATPNQKMRDSLDTTGRLSKTLENMDFFNNIGQVSDSLKESIIRVVLKSSSLEKIFDLLVLTSNIFSKLVDTKDLENYYYHQRQRGHSTRGLSDDNIGLLDYAFVKLTMDNDIFTETFFNTYKSFTTTTTVLENMAKRYVGAKSCSVSISKILDRSDDSKMKINEDTNLVSSSLYDQNFPVWDMKVTDDENINLIYMAKIQIGAAEAILHLVKNHYSDFTDDLCNNSTLLDIIKIMEQEVSTEWPTRIANSKLQKSLPENFVIETENLLTTLTDLFHGIKSAYQKQLYRPIGVNRTQKRITDILNSFNTFSFTDLNNIIDDPSFSDDMIRSFQKLHSTNYEDILEWIYQLDNFISKKFNLVSKKDWIVLFQELELLSKESLVSFFNYPLHFKSSKLINPGYLQLHEFEISNLFTWISTLILKDDNGTESLFFEKLPQSIKLLIKLHTSLTTFFVMEISNVNKSSSERLTTCKVILQILNYIRWKNGSLDLFDSEEDESPHAICPHIPAFIETAIAHAIISPESRNYELSWIKASEKLSDPTKGTQNLRSISNVLEKIDDIHIKRFIEIDDVFSKNCKNLCPCPGWFISRLLEISQFVPNMSITNSKLINFDKRRFVNNIISNVLDLIPNEREFPLDIEMSDENPSKRTTFGRILFNNFEDVNKVYRKKTKKVSESEAISERFQEQGVFNEILVNEIEKIKREARKLEVLLDQEKILKNSAALHQAVPKKNRKSVIISGTHSDNDHSYNINKNTGQTPSLGSVMESNNSARNRRDSRASFSTNRSSVVSNSSHNGVSKKIGGFFRRPFSIGGFNTSSSNYSLNSILSQEVSSNKSILPSILPEVDSMQLHDLKPSYSLKTFEIKSIMEIINHRNIPAYYYAFKIVMQNGHEYLIQTASSSDLTEWIKMIKASKRFSFHSKKYKGKTHNKIFGVPLEDVCERENTLIPTIVVKLLEEIELRGLDEVGLYRIPGSIGSINALKNAFDEEGATDNSFTLEDDRWFEVNAIAGCFKMYLRELPDSLFSHAMVNDFTDLAIKYKAHAMVNEEYKRMMNELLQKLPTCYYQTLKRIVFHLNKVHQHVVNNKMDASNLAIVFSMSFINQEDLANSMGSRLGAVQTILQDFIKNPNDYFKQ
The following text describes a protein:
Function:
Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLKGSTLKALDVRILWPLIETRSAGKCKLHNPRPTPNRNIAAAKLIVTLRLLLSCCSGGHQRSFSSSTHRSYITFNDFRKKHRWYTKKELVGYSMQDMYSVVSDVSNYHKFVPYVKRSDVHSRGSEGFKADLIVGFPPLNEAYTSQVTLVPPSLVKSECHDGRLFNYLLNEWSFKPGLKDIPNSCVLDFKVSFEFKSLLHSNVANIFFDLICDQMENAFIQEVRRRSGPPSIRSHVLTSDRS
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds DNA of heat shock promoter elements (HSE).
Subcellular Localization:
Nucleus.
Domain:
The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domain.
Sequence:
MEWEEESEAARQKAAAASASVVPAPFLTKTYQLVDDPATDHVVSWEDDDGGESASSFVVWRPPEFARDILPNYFKHSNFSSFVRQLNTYGFRKVVPERWEFANEFFRKGEKQLLCEIHRRKSAAATWPPFPPPPPPFFAPRHFAAGAFFRHGDGMLHGRLGALVTTTERRHWFESAALPVAPSSRLLSQLGPVIAPARRAAATPEEEALMQENHRLLRGNAALVQELAHMRKLYSDIIYFVQNHVRPVAPSPAAAAALHGLGVLRPPPAGGKAPASEVRGASGRSATSSSSLTVAEDQPTLLALRLPRTTEKIINEVSGGNGGGSTKLFGVHLSSADEQTSSGASRKRSPPQEQPPTSPAPKRTLVVEHSELRLSIVSPP
The following text describes a protein:
Function:
Required for cell fusion events during development including the fusion of anchor cells (AC), vulval A and vulval D rings, and late epidermal seam cells. Required for amphid sheath cell fusion induced by entry into dauer stage.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Apical cell membrane.
Sequence:
MRLWQWSIAVAICLVMVTEARLRRHHRKRRFVSSNFDEFYCGESAHAQSQFEEERESNSSKVSSVHSTQFNWGLDNTICIKLQNVVHVLKYERLEQRYPIENSYTFSVPLIDTNCKCHCYGFGTNDVCNVEKYADDRNCTTSSEFPTCYTKYHPAVEPLDCPVTSIPAKACCDIKLKPRDGRMFRAVKLQQPINDMIISHSIFANNSGKMMKVLGPDEFRINLLKGKEQFELTEYHRISVQLVASSPQQQLREGMYYFPEENHNDLREGKINEITESDLDKLGWYRRVGNDWQVATSGLLLRNAHKVVIKNCKGQVHMDQFSGTKNFVLRGTQYNDTYNERRVSDNNFVRSVKVDESSREITIVHEHGTAAQVSLKTDTRPNLTKSQSLLANFTGSITLDHDGNRMLNVTFFGVKGTVHIKMYVNDRKLIATFACTAQFGTSLKDDGSRISLPSTINQAQWVCILPDEQPTKSEICKWIPYEEKAMRTPRQEQSWSKGHSPCSQAECNSLKSGVSDLFPWIMNFDYFMAHGGDFTEWLKIGIHIVIAVGLLLLLILLFTKCLVPLACCSLSIPFKNRNKKKKKKNSSDY
The following text describes a protein:
Function:
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
Subcellular Localization:
Nucleus.
Sequence:
MASKRKRKEKQKDFAKAKLKVGKTAQKPDNYTDTSFKSKTISLPNQSIASSSNYGASSGASRSSLSTGPSLAVLTHQLSLTKHHSSNTRKEVLNYLQTHLPENPSYYKNIMTSILPLILDEDKEVRKALMSLLSAIFAKQPGLIDLHLRSTILFILSAMSHIIPNIRTTSTHFLRIIVENSHGNLINSYFVKIMRNWFVLMGWSLNEQDSKQLSMAVTTLSITAMNANSKQARIGHLQNLNKFLSKTLQHDQDKDKNKDMKLNITIHPQSYKYLLTDTVQPYQPLKLFVKEFKSEGSGSNGSGISMLDLNTISTEDLDTRKKIMNDVFKPLMIKNLNTFVKEGGEIGREANNCISIVTQACTSSSE
The following text describes a protein:
Function:
A bifunctional enzyme which catalyzes the dehydration of anhydrofructose into ascopyrone M, and the isomerization of ascopyrone M into microthecin. To a lesser extent, can also act on 2-dehydro-D-glucopyranose (D-glucosone), leading to the antibiotic cortalcerone.
Sequence:
MYSKVFLKPHCEPEQPAALPLFQPQLVQGGRPDGYWVEAFPFRSDSSKCPNIIGYGLGTYDMKSDIQMLVNPYATTNNQSSSWTPVPLAKLDFPVAMHYADITKNGFNDVIITDQYGSSMDDIWAYGGRVSWLENPGELRDNWTMRTIGHSPGMHRLKAGHFTRTDRVQVVAVPIVVASSDLTTPADVIIFTAPDDPRSEQLWQRDVVGTRHLVHEVAIVPAAETDGEMRFDQIILAGRDGVDCLWYDGARWQRHLVGTGLPEERGDPYWGAGSAAVGRVGDDYAGYICSAEAFHGNTVSVYTKPAGSPTGIVRAEWTRHVLDVFGPLNGKHTGSIHQVVCADIDGDGEDEFLVAMMGADPPDFQRTGVWCYKLVDRTNMKFSKTKVSSVSAGRIATANFHSQGSEVDIATISYSVPGYFESPNPSINVFLSTGILAERLDEEVMLRVVRAGSTRFKTEMEFLDVAGKKLTLVVLPPFARLDVERNVSGVKVMAGTVCWADENGKHERVPATRPFGCESMIVSADYLESGEEGAILVLYKPSSTSGRPPFRSMDELVAHNLFPAYVPDSVRAMKFPWVRCADRPWAHGRFKDLDFFNLIGFHVNFADDSAAVLAHVQLWTAGIGVSAGFHNHVEASFCEIHACIANGTGRGGMRWATVPDANFNPDSPNLEDTELIVVPDMHEHGPLWRTRPDGHPLLRMNDTIDYPWHAWLAGAGNPSPQAFDVWVAFEFPGFETFSTPPPPRVLEPGRYAIRFGDPHQTASLALQKNDATDGTPVLALLDLDGGPSPQAWNISHVPGTDMYEIAHAKTGSLVCARWPPVKNQRVAGTHSPAAMGLTSRWAVTKNTKGQITFRLPEAPDHGPLFLSVSAIRHQQEADAIPVIVQGDSIELSAWSLVPAN
The following text describes a protein:
Function:
Beta-mannosyltransferase involved in cell wall biosynthesis. Required for beta-1,2-mannose transfer on phospholipomannan. Required for pro-inflammatory response in macrophages through phospholipomannan-induced TNF-alpha production.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MGNYKPSIKQYVVTVKAIKSSQFGRLGICAVVLLFVLGYPFYFISNNPFDTSIRYQYVDPYNDTTRKYTTIEKQHTDIGGNGTTILYPKNLQLDQTALSQLLNTTETTNPFVQYIGNSSSIAFSQLNQTLVNHSIQVFDPFSNSDNCSDLMTETQLTISQNIIIKESFEIMVKRLMHQLDTEPAFKELAPFFQNKLSLHLRMRSYHKHFYKFARTSVWLKDYGVHLMISRVIYSQKGKKGDPQISLLYTQLYDTNWQELTNTDLLVSMQDITGEYKLEKLQFPRFLPMPFYYNPKLTKGRWYGPEDARIMLVKNQLDMEEPVVIYNSYHRQIANHTTTGKTDGSVELNFEFYRSMFVGWPFRYQLGKSNTDGFVDDRFDNVKFTRVAELKIHNQTRASIEKNWTPFVDPSERDPEDKSLYIVYQWDKLRILKCDISNLVTDDGFIHYSACRFKQDTKHDEVEKVGPIRGGTELIPTIINNKQLWVGFLRAHIDKCGCGKAMYRPNMVVLQKTDMGTFQVAYLSSYISFNIPVPGWKTHEIQCGKRDPNVLIPNGISNWEVATIDGIERDVLTMTLSAADEDNILMDIHGLKTVIKNLITNQKHGNEFNSDSVQMKCVVAYSIEFCRAYGEEQARLGLTGGWLPSHN
The following text describes a protein:
Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of the insulin signaling pathway, modulating insulin sensitivity by limiting PIK3R1/p85alpha abundance in adipocytes. Targets PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), for 'Lys-48'-linked polyubiquitination and proteasome-mediated degradation.
Domain:
Recognizes the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex substrate, PIK3R1, through the 4 tandem C-terminal Kelch domains.
Sequence:
MSTQEERQINTEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAAALQMIIAYAYTGNLAVNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYRQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPNDKSVVVQGLYKSMPKFFKPRLGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLFVRVKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDCIYVMTLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRETHLNERAKYVTYQYDLELDRWSLRQHISERVLWDLGRDFRCTVGKLYPSCLEESPWKPPTYLFSPDGTEEFELDGEMVALPPV
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MVLLYDCIQEETLLSNSPCHRQIDLDLDQDFSGCTASRTQFLNFLLKWLTDWKNEAADRDVKIRFTYAKVWTPLSRSLESCLMDAVALRSIKKYPLTLKSGLECKILEGFGDKICSQIDEKLNSEFAKSSFQSVEDFIKSFDKPKVNMHNSNGRNISKQPSASKRGDDQCIAIGQNEYNNHTITNIRDADDDGDGCDNNDNIICIDDEADDDIYCNESGEMSKNHQFTGLLEKELDNCVSAFKESSSTKPPTLASFITSSCSTTIPTATTTNPSTSSTVLSTSSDTFRFMYVMDDGKETCKKDQAVIDIDDGTSVVKFLIKCKYTDLLLSGKEYSLDYTSSNCIEILNNPKLYRSCDDIEYIYAYLNDEHAPDYSINNSQLVPISSTPTTLAASSTTTTMPSSLTSTSCNNNMDSLFQRPIVSDCTFTATTLTASTFRRSKLKSAHYRPTSPTTSSATASMTSSTTLTPSANSNENKKFNKTKSENLDSKHKKLKHDFLKCNEFNQPMQQRQQHVTLTPLHRQHSATLTDDIINDNINNSNNDNKTNILISSSTADVTFSSGSFDVLLCVDCRESMGPASLADDVLMKELIKNNVQHDVRQLHLGDFLWVARCRDSGMELVLDWIVERKRMDDLGGSIIDGRFREQKFRLSNCGLKHVIYLIEEQGKQHSSLPEATLNQAIINTQVVDEFFVKRVKHARESATYLTLVTRYLQSLYSTNKLYGFNQFFKVEQTCTSPSVLSSSSSISPPNFFLMTYSAFSEQSKKSKCLTVGRTFLKQLTQINGLTTEKAISVINMHPTPLSLFNAYDACPDDASRLEMLTNLKCGPSRRNFGSSLSRSVALMFYLQPHLQN
The following text describes a protein:
Function:
May be a cell surface adhesion protein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MSNQAFLLLLFLPLLLADTASQAGAQPLLSALTQHLDVTEILEKAGHFDNFVALLQATGLDKQINQEANQATSEGITLFAPADSAFTGLTSEKLGALSDKARAALVKYHVLPFLVTSISVFEDMTKQPLRTMGYTGKGVPLNVITTAGHHVNLTTGLVNTRVGDTVFSGGKLAVYHLDRVLFPPDLFGSKASAPTTSSAPTMSLSPRERQKKLLPEDANFTESAAAGGLCRLSLMAVGGGAALLWLL
The following text describes a protein:
Function:
Required for innate and induced resistance to pathogens such as compatible and incompatible isolates of P.syringae and P.parasitica.
Subcellular Localization:
Nucleus.
Sequence:
MKLSFSLPSKSKPKVTATTADGNNAVDDGTSKEFVTEFDPSKTLANSIPKYVIPPIENTWRPHKKMKNLDLPLQSGNAGSGLEFEPEVPLPGTEKPDNISYGLNLRQKVKDDSIGGDAVEERKVSMGEQLMLQSLRRDLMSLADDPTLEDFESVPVDGFGAALMAGYGWKPGKGIGKNAKEDVEIKEYKKWTAKEGLGFDPDRSKVVDVKAKVKESVKLDKKGVGINGGDVFFVGKEVRIIAGRDVGLKGKIVEKPGSDFFVIKISGSEEEVKVGVNEVADLGSKEEEKCLKKLKDLQLNDREKDKKTSGRGRGAERGSRSEVRASEKQDRGQTRERKVKPSWLRSHIKVRIVSKDWKGGRLYLKKGKVVDVVGPTTCDITMDETQELVQGVDQELLETALPRRGGPVLVLSGKHKGVYGNLVEKDLDKETGVVRDLDNHKMLDVRLDQVAEYMGDMDDIEY
The following text describes a protein:
Function:
Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MAGAAGLMAEVSWKVLERRARTKRSGSVYEPLKSVNLPRPDNETLWDKLDHYYRIVKSTLLLYQSPTTGLFPTKTCGDDQKAKVQDSLYCAAGAWALALAYRRIDDDKGRTHELEHSAIKCMRGILYCYMRQADKVQQFKQDPRPTTCLHSVFNVHTGDEILSYEDYGHLQINAVSLYLLYLVEMISSGLQIIYNTDEVSFIQNLVFCVERVYRVPDFGVWERGSKYNNGSTELHSSSVGLAKAALEAINGFNLFGNQGCSWSVIFVDLDAHNRNRQTLCSLLPRESRSHNTDAALLPCISYPAFALDDEVLFSQTLDKVVRKLKGKYGFKRFLRDGYRTSLEDPNRRYYKPAEIKLFDGIECEFPIFFLYMMIDGVFRGNPKQVKEYQDLLTPVLHQTTEGYPVVPKYYYVPADFVESEKRNPGSQKRFPSNCGRDGKLFLWGQALYIIAKLLADELISPKDIDPVQRYVPLQNQRNVSMRFSNQGPLENDLVVHVALVAESQRLQVFLNTYGIQTQTPQQVEPIQIWAQQELVKAYFHLGINEKLGLSGRPDRPIGCLGTSKIYRILGKTVVCYPIIFDLSDFYMSQDVLLLIDDIKNALQFIKQYWKMHGRPIFLVLIREDNIRGSRFTPVLDMLAAFKKGIVGGVKVHVDRLQTLISGAVVEQLDFLRISDTEELPEFKSFEELELPKHSKVKRQSSTASAPEVEQQSDVVIAEWKNKPTHEILQKLNDCSCLASQAILLGILLKREGPNFITKEGTVSDHIERVYRRAGSKKLWLAVRYGAAFTQKFSSSIAPHITTFLVHGKQVTLGAFGHEEEVISNPLSPRVIKNIIYYKCNTHDEREAVIQQELVIHIGWIISNNPELFNGMLKIRIGWIIHAMEYELEIRGRNKPAVDLYQLSPSEVKQLLLDILQPQQNGRCWLNRRQIDGSLNRTPPGFYDRVWQILERTPNGIIVAGKHLPQQPTLSDMTMYEMNFSLLVEDMLGNVDQPQYRQIVVELLMVVSIVLERNPELGFQDKVDLDKLVKEAFYEFQKDESRLKEVEKQDDMTSFYNTPPLGKRGTCSYLTKVVMNLLLEGEVKPSNDDPCLVS
The following text describes a protein:
Function:
May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.
Sequence:
MKYEIDKKRLVIRVVPEREEDLYFIYLLIDKGDIIRGWTVREYKPDGVKEGERIKMYLAIKAEALEYHKFRGSLRVRGPVIEVQEGVEGVKGRRHTFDISIGREIEIEKNEDKPLEVVDEILNMAKNVMPRILLISIDDEEAAFAYITSIGVNVLHVVRNDAERSRGDSLLHDYLVTIGKIAEDLKRRLNPDKVVVTGPHIVVEQIGNYVRGDRVAQSVGGLAGIYEFMRAGLYDGLKTEMGIKAYERLMQLLATERNLVAIGLEEVEMAVAAGRVEILLIVDSYIKEDPHRAWDLIYKVYATRGKIYIIREDLEIGTSLKAMGGVASILRW
The following text describes a protein:
Function:
Controls the rotational direction of flagella during chemotaxis.
Subcellular Localization:
Cell inner membrane. Cell membrane; Single-pass membrane protein.
Sequence:
MAKEESLELESTEAPKSKKKLFIFIGVGVLAALLIGGALWFFLGSSDDAPVEAAEGVKTTAEAPAAEPALAAYVPMPRPFLFNLPGPDRARLVEIKVQLMVRGQDDEVLTQKHIPLIEDALLTTFSGADVQKLSTQAGKDELRQLALLSVQNTLQPVTGRKVVEKVLFTGFVMQ
The following text describes a protein:
Function:
Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
Sequence:
MLDKKYLFPEDAVRLIFKHITQRSLSSEIVPIEEAYSRVTAEDIISPEDLPGFNRSTVDGFAVKASDTFGAKESSPAYLKIKADIPMGAIPDFSLSNGEAASIATGGMLPEGADAVVMVEHVNTVSDDLIEVLKAVSPGENVIFLDEDAKKGETIIKAGHRLKPQDIGALAGLGIKDVKVIRKPVISIILTGDEIMPHTEKVTPGKVRDVNSFTLAGLCYENGAIPLKMGIIKDDYNEIKKAVTKAYELSDIVLITGGTSAGTKDLTAKIINEIGLPGVLFHGASIKPGKPIIGGVCNGKPVFGLPGHPVAVYICFELFVKPVINYVFGLTDKNFKKTVKAKMSRSIHSQAGRQDFIRVYLEEHNGEIWATPLLSKSGLIMSLVKAHGIVHIPSELLGILEGEEVFVEIID
The following text describes a protein:
Function:
Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ufm-1, a ubiquitin-like modifier protein bound to a number of target proteins.
Sequence:
MEATAGGSRRRPTLLRLLCPKKSLVSPPTPSLRWLLGSPRFLPPLTVAAALRSLPDGASSPDLQREAEEIRGLLVRGFDIVGAVHVGSADAGGALELARAVRERLYGERASHGMVGGCVELGTGEIRFVVSEGDGVEAVEVTEVVWEDDPGRLLWEKGCLLRCELLLKLPLYVPSDDTSGIEARFYSLIESTASKLRDPHVSYLIEGPRTTPGESHYSIILHGNDLNSVPHLSRNGSTEEYDANIVSCSKFFPAKRSLSLTRENADAIQITILSNQSFNSSKASTPAVEYFPAPALASLRAINLKLDILCYTSVDFPVAAAVSELVIPGLADQLSIMKKAIVSELTTQQPQLSPYHFVPPGLLIPVTTIYDTRYGEIEEKQSELRRNLHLRLQLPLDRPLLRISNALNFSIGGTDKKASKSGSSLLRDVHREIPSSGVSGGIISLIDGSYEYYHYLHDGIDDNGWGCAYRSLQTIMSWYRLQQYSSINVPSHREIQQVLVEIGDKDPSFIGSREWIGAIELSFVLDKLLGVSCKVINVRSGDELPEKCRELAIHFETQGTPVMIGGGVLAYTLLGVDYNESSGDCAFLILDPHYTGADDLKKIVNGGWCGWKKSIDSKGRSFFLKDKFYNLLLPQRPNMV
The following text describes a protein:
Function:
GTPase-activating protein for the ADP ribosylation factor family.
Subcellular Localization:
Cytoplasm.
Sequence:
MGNVKSSLQDCIELDESMLSIRTDSPAGYNPKFVFIRRTLYLLVDEELTRSGKFIISLRELESEGLLDYKFVNGTGQNAPIVIKQIKNSSKYVLNFHPSMKEGVHKFTIRFDKKRICRVYIYCERAKEDAGDAAPTVPAPSTAPAGSPTPAPAPNTRNPAGMTAVSAVVSAAAPATAPATVHTTPPSPPPPPPGLHDPVPNFIQDGPQFRTQLANWESILFLFRSHLKSLYERSTKLKELLQMTSKEFNLLSNDFNELHCILKDQPVSSVFRHLLLSSSSVCVSQARLMMKKATASQEDLASAIQQYLNTIDLKAVSSSKKQYHDQAKDFYSYVGKNLSQKSDSKLLPRRIQFELQRFDYFHSLLQYVVGCNARDFAVSLARFQSSIDPNNKNTNMHLVKKYRSHFLPFNKIKSQQRIRLSKVSNYSDLNDFYQLASATSEPNKPLKEGLLWSYRNNGWHKQWVVLQGSQLSEYSDWKTKAKVLSRPAINLTFVCVKRSEKKPNGFDIITTDGEARSFQAESEDEMKQWLYALHSAVGIIAIEETDENKDPLSIVRNADPSNSACCDCRSDKQVEWISLNILCVVCINCSGVHRSLGAHVSKMRSLTLDSFSSPESLQLLKCVSNQNVNSLYESEDLPPIFPENSIDQRKSYITDKYVSKKYVNRTEDISKLHISLIKAIHLESIYLLQKCFAEGVSLCEDYWLQNDGNDSLFQYSLKHWEGTKENPVFTVTEFLVLNGLHVDDLPTSHEHRALWSPGQLSYWSSKYKNHNCLHNRVGAKKLPEVPTSAAISLHTRNPRHTTDFTDSICSPDIPSSAEGSSKNDGQSAPGPATTRSRRWSVGMGQHMAGTTSHHFTSPILGKSRHLKFPKIQK
The following text describes a protein:
Function:
Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).
Miscellaneous:
MISCELLANEOUS: Unlike the enzymes in the radical SAM superfamily, Dph2 does not form the canonical 5'-deoxyadenosyl radical. Instead, it breaks the C(gamma)-S bond of SAM and generates a 3-amino-3-carboxypropyl radical intermediate.
Sequence:
MLFKTIFYQKLQKKVTTLFNLETERVIREIENLNKNNPKVIFQAPEGLKLKVEKEIEKIKQYFKQKNINIEIYLWGNTCFGACDLIDNHVKNLNVDLIIHYGHEKLSYANPEIKTLFIPAYHIFNKDEEEKILNDIKNFIEKHKSGGKKVAIATTIQYKKLLKDFNPSIILGCRGEVKEGDVILFVGTGRFHPLMIAYKYQKEVFIYNPLSKCFDKISEEEINKFIKKRILAISKLLLNKPKKVGVVLSTKKGQCRKRVFDEIIKLLEENDVNYLPILVDNISPDILFYDVDCYIIVACPRIVLDDYILYKKPIYTPEEFKLFLKNSFKYKFDEIKEDDF