lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Member of the two-component regulatory system YvcQ/YvcP. Probably activates YvcP by phosphorylation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMMYIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALWTKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSFPTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIKRRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETRLSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESKEGAGTVMTIVFSSDTLVNVTAL
The following text describes a protein:
Function:
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, dendrite. Membrane; Multi-pass membrane protein. Note=In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree.
Sequence:
METFSHRVNSYIDSWMGPRDLRVTGWFLLDDYIPTFIFTVMYLLIVWMGPKYMKNRQAYSCRALLVPYNLCLTLLSLYMFYELVMSVYQGGYNFFCQNTHSGGDADNRMMNVLWWYYFSKLIEFMDTFFFILRKNNHQITFLHVYHHATMLNIWWFVMNWVPCGHSYFGATFNSFIHVLMYSYYGLSAVPALRPYLWWKKYITQGQLVQFVLTMFQTSCAVVWPCGFPMGWLYFQISYMVTLILLFSNFYIQTYKKRSGSRKSDYPNGSVNGHTNGVMSSEKIKHRKARAD
The following text describes a protein:
Function:
Promotes the splicing of group II introns in chloroplasts. Required for the splicing of intron 2 of plastid ycf3 transcripts, a factor required for the assembly of photosystem I (PSI). Involved in the splicing of atpF, ndhA, petB and rps16 chloroplastic transcripts. Required for the assembly of PSI.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MATTSPCAAPSPSLRCPLALSHPFASPPPPPALRLAGPKLLPGRLAVSPPPGIPAVASALESLILDLDDDEEDEDEETEFGLFQGEAWAAADEREAVRSPELVVPELEELPEQWRRSRIAWLCKELPAYKHSTFTRILNAQRKWITQDDATYVAVHCLRIRNNDAAFRVYSWMVRQHWFRFNFALATRVADCLGRDGKVEKCREVFEAMVKQGRVPAESTFHILIVAYLSVPKGRCLEEACTIYNQMIQMGGYKPRLSLHNSLFRALVSKTGGTAKYNLKQAEFVYHNVVTTNLDVHKDVYAGLIWLHSYQDVIDRERIIALRKEMKQAGFDEGIDVLVSVMRAFSKEGNVAETEATWHNILQSGSDLPVQAYVCRMEAYARTGEPMKSLDMFKEMKDKNIPPNVASYHKIIEIMTKALEVDIVEQLMNEFIESDMKHLMPAFLDLMYMYMDLDMHEKLELTFLKCIARCRPNRILYTIYLESLVKVGNIEKAEEVFGEMHNNGMIGTNTKSCNIMLRGYLSAEDYQKAEKVYDMMSKKKYDVQADSLEKLQSGLLLNKKVIKPKTVSMKLDQEQREILIGLLLGGTRMESYAQRGVHIVHFQFQEDSNAHSVLRVHIHERFFEWLSSASRSFDDGSKIPYQFSTIPHQHFSFFVDQFFLKGQPVLPKLIHRWLTPRVLAYWFMFGGSKLPSGDIVLKLSGGNSEGVERIVNSLHTQSLTSKVKRKGRFFWIGFQGSNAESFWRIIEPHVLNNFASLVTQEGSSIGSDGTQDTDTDSDDDMQMSDTERDE
The following text describes a protein:
Function:
Flavin-dependent monooxygenase (FMO) that catalyzes the decarboxylative hydroxylation of 6-hydroxynicotinic acid (6-HNA) to 2,5-dihydroxypyridine (2,5-DHP) with concomitant oxidation of NADH, a step in the aerobic nicotinate degradation pathway.
Sequence:
MRGRQKIAIVGAGLGGAAAATLLQQAGFDVEVFEQAPAFTRLGAGIHIGPNVMKIFRRMGLEQKLELMGSHPDFWFSRDGNTGDYLSRIPLGEFARREYGAAYITIHRGDLHALQIEAIQPGTVHFGKRLEKIVDEGDQVRLDFADGTHTVADIVIGADGIHSKIREELLGAEAPIYSGWVAHRALIRGVNLAQHADVFEPCVKWWSEDRHMMVYYTTGKRDEYYFVTGVPHEAWDFQGAFVDSSQEEMRAAFEGYHPTVQKLIDATESITKWPLRNRNPLPLWSRGRLVLLGDACHPMKPHMAQGACMAIEDAAMLTRCLQETGLSDHRTAFALYEANRKERASQVQSVSNANTWLYSQEDPAWVYGYDLYGQQLESGEAA
The following text describes a protein:
Function:
The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein. It acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization. The carboxylated form binds strongly to apatite and calcium (By similarity); The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development.
Subcellular Localization:
Secreted.
Sequence:
YLAPGLGAPAPYPDPLEPKREICELNPDCDELADHIGFQDAYRRFYGTV
The following text describes a protein:
Function:
In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7. Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal. PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5; Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome matrix.
Sequence:
MSLRDLVEAQCGAPNALVKLTGHVSQDRALQQVRDFHVLRACFGMVLNTRMTLEGRVCNLAQLVDEFLAERHGPGLRQRMAPQTFHMAALLQEMQDIEKVYQGMPQPVAGDLGTSKEWAREFLPPSEAPKPAHPVAATAADWSQEYAANRGTIGVSSVKWAEEYLVESEDLAGIGFPVLMCLFRAWTEAAEGNKSLSEVAGELLKGVNDDVMMETEFMQFVKELSQGSAGLDEPVSAQAEDFTREFVEAQQQRRQQQQAQVKKRREALRCQAGCRKRVGSDADFWENLQKEWDHMARETPSSHPWLSEYENLSEPYREYKFAEDNPLEDVENPFEEGLKKLQENDIPSAVLLFEAAVQKNPQHVEAWQYLGTTQAENEQDPAAIAALRKSLELNPQNLPALMAVAVSYTNESLQTQACDSLLQWLKNHPRYQALVAEGAGAASEPTAFPLSSIMSNEQHGRTRDLFIAAARLSPSDPDPDVQSGLGVLFNLSGEYDKAADCFRAALTVRPNDSLLWNRLGATLANGSRSEEAVDAYRQALQLSPGFIRSRFNLGISCINLGSYREAAEHFLTALNMQSAGRGPLGRQQPNTSVSENIWSTLRMVFTLLNRPDLYKVADRRDLPFLNREFRMES
The following text describes a protein:
Function:
2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex (OGDHC), which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation.
Sequence:
MFHLRTCAAKSVHKSWDIFFRNTNAGAPPGTAYQSPLSLSRLGFYGLHESDLDKSTRFEEFLQRGRLNVLANVIRYHLGMYHRRSSPYPTDVARICEEAFTRRQILLPFRKPLIVFTPKSLLRHPEARTSFDEMLPGTHFQRVYYDLTRAKPVWYAGRKTHLTELQRFLDTAFDLDAFKK
The following text describes a protein:
Function:
Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54.
Sequence:
MFARANTRKHKKWEGDGFLTIHANGETELTEECGREIARSTFTSKKRAELSDGHILMVGGYEVEIQEEVDALPVSAPVQPPTPKKIPSPVAAQAAAIGRFKSAPSFKRTFATASACASPAAKRRFEDQQQPAAPAAPAATAVLSPMAKPRPFSASSLIKSASSGSAKPFCSPLVGNRQQEKVAPMVINEREVERGATPILLEGWLAAHLREHQKQGVAFLVDKLKSRGGGAILADDMGLGKSIQTIATCWTLLKRKTPKVEDGVRKVLVVVPSSLLHNWRAEFAKWFRATRTPAMLVRKVSDIGLFASAHKITPFLVVSYDMALRYAPALSSCQFDLLVCDEGHRLKNASGKLREALCSLSIPRRLLLTGTPVQNDLDEFHSLLDFVLPGNFGTPAEFRSLCREGGEEEGGGGEGDDSETSPELARLHAAIGECMLRRTSEVNVSHLPDKHEYVLFCAASKLQIKIFEAIADHVTGEPLVLIDQMRKASNHPAILYKHLQKGNADSENTRVSYSSILSMFPRDFGSRTASVKDSGKLSVLVDMLVSFREHGECTVIVSQYTKTLDMIAILCSTLQFRIYRLDGSTPVADRQKLVNDFNQSRDSTNIFLLSSKAGGVGLNLIGASRLVLFDLDWNPASDLQAMARIWRDGQPRACHIYRLVTTGTIDEKILQRQIKKTGLAAIVNVVESLNGQTDTLSFRDEDLKDIFTFKETASNTHDLLECACGGDGLLPLEREEEEEVERAERDDIDEDEIAASVVRAGGVETTTVSIDDGEDTVGEGEEEEDTAELPTEPASMAELFRWRHYAPNNDVPWQHLKAQAGLGKMGLEEVTFALHYCNNF
The following text describes a protein:
Function:
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Subcellular Localization:
Secreted.
Sequence:
MTNLLLRESWTFDMRTDLLYYSMLCTSLSLYLLIMLTRQIKSQSVCSRESVEMVKQIAAKLNNVENDCMMYTPTQANYKQNCSKSTITCFAFEVSVLSVEIQVESLAFRQLQRILNRVTKRLQDEMEMKCPVCELYKEESTKTFLNTLQHILEQMNAERICAP
The following text describes a protein:
Function:
Adhesion molecule that binds to leukocyte adhesion LFA-1 protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins (By similarity). Isoform 2 may modulate binding of membrane-associated ICAM4.
Subcellular Localization:
[Isoform 1]: Cell membrane; Single-pass type I membrane protein; [Isoform 2]: Secreted.
Sequence:
MESALLLPSLLLVAAYPRGGSPQQEWMQSPPAPSVTSAPFWVRLNPELEAVPPGGSAWLNCSHNCPLPVHSSLRTQLRQGKIVNGSGWVSYQLLDVRAWNSKVRCVVTCAGETREATARITAYKRPRSVILEPPVLVGHKYTLRCYVTHVFPVGFLVVSLRRGGRVIYHESLERFTGSDLANVTLTYVMRAGLNDLWQPLTCHARLNLDGLVVRSSSAPVMLTVLALSPASIALASTSIATLVGILLAVGAVYVRKYLAVQT
The following text describes a protein:
Function:
Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.
Subcellular Localization:
Nucleus.
Sequence:
MSYGRPPPDVEGMTSLKVDNLTYRTSPDTLRRVFEKYGRVGDVYIPRDRYTKESRGFAFVRFHDKRDAEDAMDAMDGAVLDGRELRVQMARYGRPPDSHHSRRGPPPRSRSRSRSRSRSRSRSRYSRSKS
The following text describes a protein:
Function:
AMP deaminase plays a critical role in energy metabolism.
Sequence:
MNQKHLLRFIKKSYQVDADRVVYSTK
The following text describes a protein:
Function:
SOSEKI proteins (SOK1-5) locally interpret global polarity cues and can influence cell division orientation to coordinate cell polarization relative to body axes, probably by guiding ANGUSTIFOLIA (AN) polarized localization.
Miscellaneous:
MISCELLANEOUS: 'Soseki' means cornerstone in Japanese.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=SOSEKI proteins integrate apical-basal and radial organismal axes to localize to polar cell edges.
Domain:
The DIX-like oligomerization domain is required for polymerization, edge localization and biological activity.
Sequence:
MEARMKKYSREVSPERAKVWTEKSPKYHQKIKKVQIVYYLSKNRQLEHPHFMEVLISSPNGLYLRDVIERLNVLRGRGMASMYSWSSKRSYRNGFVWHDLSEDDLILPANGNEYVLKGSELFDESNSDHFSPIVNLATQNMKQIVVEPPSSRSMDDSSSSSSMNNGKGTNKHSHEDDELSPPALRSVSSSGVSPDSRDAKNSSSWCLAEYKVYKSEGLADASTQTDETVSGRSKTPIETFSRGVSTDEDVSSEPETSENNLVSEASCAGKERESAEISRNSVSPPFSNSASSLGGKTDTLESLIRADVSKMNSFRILEQEDVRMPAIPRLRASNMLMQLISCGSISVKDNNFGLVPTYKPKFGHSKFPSPFFSSSFMMGDLDRLSETPSLMGLRMEEKEYFSGSLVETKLQKKDAADSNASLKRSSSYNGDRASNQMGVAENGDSKPDSSKNNPSSRKASSILGKQQPLVSEKRRDSSEDTTKNIPCTTKTHDACSKRITESLRKPDSFREDEERVIKIDERLASGARVRIESKVPSEEP
The following text describes a protein:
Function:
Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54.
Sequence:
MVEIGNEFYVYEGIEKKLYAYQREGLLWMWGLYLKKRGGVLGDDMGLGKTVQVIAFLSGMFDADLIKSVLLIMPVSLIPNWKKEFQAWAPGIRVFDYHSSTKKEKERSLARVQNRGGVLLTSYGMVQTSAEILSAQGGRKFVWCYLILDEGHKIKNPTKTTKAVYELPAKHRLVLTGTAIQNNLRELWALYNFAHQGTLLGSLATFKSQYETHINRSREKDATAGERLLGIEISKNLMEKISPFFLRRTKAEVLENKENTEQETDSLRPKLCFTAKKNDLVVWVYLSEVQKKIYREFLESEEVANILMTKKSPLVQLTILKKICDHPRLLSKRACVQMGMYDDMTQDQIEEFLDKEEGNSMTISDVPDDTLLAESGKMTFVLELLLNLKSEGHRTLFFSQSRKILDIIQRILLNRGFRVTRLDGTITKLCERDRLVTQFQTRSLADIFLLTTQVGGVGLTLTSADRVVIYDPSWNPATDAQAVDRAYRIGQSKNVVVYRLVTCSTVEEKIYRRQIFKDSIIKQTTGKQRDPVRYFTKQELRELFTLEDPSHSATQVQLAEMHSHHKRTDHGLDVHIEFIERRNVFGVSHHDLMFSEETAVDGPEEYVDGEKEHVRMRVEIAHRMVTSEADFVMGEIQNKESYTVPLNITVKTRQPVPYQPTPNLFPIVVPDEDSADTKGVGNVTIDLDELDEPIDIDSLHSINKSLANLTVHSSNQSASILVEESDEELFPEENVQSDSIVIDSDDEELDAKPCTVDYSEIKGIKADIKVEQKLACGTATAWKSEPEDEKNVRSPLRMSVLKMKEEQESSGRTAADCKIASKGGSFFSPLRNAMESRKGDSEVKTPRLLLKTDLSFIDHSSNSAGLVPKKEFFSSANSSLDNTSFVSLTPSSAKGVKQESPTESNTSGQAMADNVRRHLFFGEDQKKDSAVKCTFNALPSVEEKRQLKKRLRDSPVFSPVPSGPKHLLLSPSAEQASPSSKQSSWSPKFKSSPLVSTPLSLKLPVECQNQVVFPGSSPSTTPSKRITPLLLGSPRRQRRSSMLKQTASPFQKALAQSRELSPVESPKKVSQNRRSSALHSQSVHEISSSDEEETGIGGGPLDAPYSKLLERSVHALSSSDEGESGGSVDEGLEEEKSSLVSEDGVAAVRNRCRANRILSDDESMSHGATSSKPAALDDTDDELITDDEDKGWGSISCSLSPQKDQSDTSDPESSES
The following text describes a protein:
Function:
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MEQTYEYAWIIPFIPLPVPMLIGAGLIIFPTATKSFRRMWAFQSVLLLSIVMIFSIYLSIQQINSSSFSQYVWSWIINNDFSLDFGYLIDPLTSIMLILITTVGIMVLIYSDNYMAHDQGYLRFFAYMSFFSTSMLGLVTSSNLIQIYIFWELVGLCSYLLIGFWFTRPVAANACQKAFVTNRVGDFGLLLGILGFYWITGSFEFRDLFEIFNNLIYNNEVNFLFVTLCAVLLFVGAVAKSAQFPLHVWLPDAMEGPTPISALIHAATMVAAGIFLVARLLPLFRVIPYIMYLISIIGIITVLLGATLALAQKDIKRGLAYSTMSQLGYMMLALGMGSYRSALFHLITHAYSKALLFLGSGSIIHSMETIVGYSPAKSQNMGLMGGLRKHVPITKITFLLGTLSLCGIPPLACFWSKDEILNDSWLYSPIFAIIAWATAGLTAFYMFRIYLLTFEGHLNVHFQNYGGKHKTPFYSISLWGKNGIKKNSCLLTMNNNESTYFFSKTKYPIDKNERKMTRPFMTIAHFEHKAVYSYPYESDNTMLFPIFVLGLFTLFVGSIGIPFNQDGVNLDILSKWLAPSINLLHQKSNNSMDWNEFLKDAVLSVSIAYFGIFIASFLYKPIYSSLKNLELINFFVKKGPKRILWDKIINGIYDWSYNRAYIDAFYTRFLVGGIRGLAEFTHFFDQRVIDGMTNGVGVISFIVGEGIKYIGGGRISSYLFLYLAYVSVFLLVYYLLFSTF
The following text describes a protein:
Function:
Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Note=Located at the septum.
Domain:
Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains form the DNA pump, and the gamma subdomain is a regulatory subdomain (By similarity).
Sequence:
MGKERKKASVSLSPQTVFAVKTCVYLALACFSGLSLWSFQHNQPYTQNWIGLLGWSLSSFLLYNFGVAAFLIPLNFGWLSFLNMKRTPAPLAFRKAAAFGAIPVCCAVLLSMISPAQNLPQFLATRVPMVVMDLQPPKAYLGGIPFYLLYDGNSFSLKLLIGAVGTGLIFLAILLCAIFYLIPKSFVLKKKALLDDLLKFLKNKFYACWNACKKLLKNLVNNKSYVPKPSLRVPSSPSVAKKEMLKLPTPVISLPLENKDLHDDSSVNRTIFLTPPHPTKRTLSPQKRTDLPNLLPKDSALAPAQTSYKPLPTPSPFVLAGDAPDLPQYHLLSKRNVHRPESLLEELKKKAAILQQTLASFGIEAAIGNICSGPTLAAFEVLPNTGVKVQKIKALENDIALNLQASSIRIIAPIPGKAAVGIEIPNPDPQPVNFRDLLEDYQKGTQRLQVPLLLGKKANGDNFWTDLATMPHLIIAGTTGSGKSVCINTIVMSLIMTSPPTDIKLVIVDPKKVELTGYSQLPHMLTPVITESKEAHSALIWLVREMELRYEILRFLGLRNIQSFNSRTRNVDIEASYDKEISEKMPFIVGIIDELSDLLLSSSHDIETPIVRLAQMARAVGIHLILATQRPSRDVITGLIKANFPSRIAFKVANKVNSQIIIDEPGAENLMGNGDMLVVSPGSFAPVRVQGAYICDDDINKVIKDLCSRFPCKYVIPSFNTYDDPGSMDPEDLDPLFNQAKTLVLQTGNASTTFLQRKLKIGYARAASIIDQLEEARIVGPSEGAKPRQILVQLSNQDD
The following text describes a protein:
Function:
Mediates sodium-dependent uptake of acetylcholine at neuromuscular junctions during periods of increased synaptic activity, may also prevent spillover to adjacent synaptic sites. Not involved in the uptake of other neurotransmitters (GABA, glycine, proline and glutamate) and there was also no inhibition of uptake by adding an excess of other candidate substrates (GABA, glycine, taurine, creatine, proline, alanine, carnitine, glutamate and betaine). Required for muscle integrity; altered transport of acetylcholine due to loss of dystrophin-glycoprotein complex (DGC) function results in muscle degeneration.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Note=The DGC is not necessary to establish snf-6 at the postsynaptic membrane, but it is required for maintenance or stabilization.
Sequence:
MSVSSNDPEQRNGRGMASGNNVDMSLYPPFIKQLDAKLPDYTREGDIEYPFEEITGVGDENRIRGNWSNKSDYLLAVIGFTAGVGSFWKFPFLVFQHGGAAFLVPYLCMLCLASLPMFFMEMVLGQFSSSAAISVWKVVPLFKGIGFAQVTISGFFAVFFNIISAWTLFYLINSFSFSIPWSNCANSWSGENCTLGTRIQCKEMNGTLLVNGSCIVEHASSNETTVIPLHDLGSIPSLKYFHNDVLMLSKGVDDFGTLNWYLGLCVLACWIAVFLCLFQGVKSSGKVVYVAVIVPFIILTVLLTRLLTLDGSLAAVFYFLTPKWEILMDLHVWGEAAVQAFYSVSCCSGGLFTIASYSRFHNNIYKDIWLVLIVDVIVSLVGCLLTFSAIGFTCYEFAISLDKFHIRDGFHLVFVFLAEALAGVSVAPLYAGLFFIMILLVVHATQMFVVETIVSSICDEYPERLRRNRRHVLTTVCALFILLSIPFCLSSGLFWMELLTQFVLTWPLVVIAFLECMAINWVYGVDNMLDNAKWIVGYWPPCYIFWKILFKFICPMVYLAILCFLWLDWNSIQYESYQFPYWSILTAWCIASFPLILIPIVGIWQFCIAKGTITQKWWRVLYPDDAWGPAMAIHRAEKFPLQIPEARRLLLPPEVEIASSRGVLQEEMPMSYDYNTSSAADVRSNRSTGHGATDVRSVAATNNTIPKFERETAI
The following text describes a protein:
Function:
Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
Subcellular Localization:
Mitochondrion inner membrane. Mitochondrion intermembrane space.
Sequence:
MTSSETTTDHPRTGKCPIDHSKFARSNEANPDAYINGIKKDQQSSSWWNSLWSRNTDVASEPDVAMLHKKPSTVDTHDHPLANPPPGCPMHKASNENSTGFFSNLFGREKQNSEATPAVQPPATCPMSNSNQKPAGVSEVLTGVDSKQQSYVPEGCPVATPKRGWFNWFGNNDDQKQEAYEVDKSNMMYKNIPQTAVDDQVVGLETTRTTSSIPKVDGKNWEYPSPQQMYNAMWRKGYRDSGENVPIMVQVHNFLNEGAWSEIKAWEREAGENTEPKLLRFEGNANKRTPRALWYMMLGRINPNRWGSGEGPFDRHDWYVQRKDNSIVRYVIDYYEAPDSADGKPVFSLDVRPAVDSFESVALRWKHWRAMRQMQQQ
The following text describes a protein:
Function:
May be involved in the regulation of cell differentiation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVQCSNNLLGILNFFTFLLSIPILSAGIWLGKNAATECERFLDKPMVVLGIFLMFVSIAGLVGACCRVSCLLWLYLFAMFLLILLGFCFTIFAFAVTNRGAGEVISDRGYKEYHVADYSNWLQKRVNNAKNWERIRSCLMYSDVCSTYRTRYASINVEDFYKSNLNALQSGCCKPSNDCNFTYVNPTTWTKTPGPYKNEDCNVWDNKPGTLCYDCEACKAGLLDNIKNSWKKVAKVNIVFLIFLIIVYSVGCCAFRNNRKRSW
The following text describes a protein:
Function:
Probable protease. Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation. Binds only double strand DNA (dsDNA) in a sequence-independent manner.
Sequence:
MASEPSSPADNDSCEGDDLEDVDSAGEETEGAGSGSARKRVSARTVLTGRGVTMAMLLSDGILEPGDACLSIDYLGQKFVGDLLPNGKIKWQGSNRVFNSPSAWAIHCKKMVNPSKKSGCGWASVKYKGKKLDIYKTIWFRKQRGVNAPDGLQASMAFACDWLLICVVIGDWLQSPANTDESMEDEEEEEEEENGDGKKEEADKPEEAKEPAKAKGNGSQPAGSERPDNRPRRPVSEVTGGLKTTTGAVSLSLSLSGSFRVKQDVKERPSVKHTSLGSRDPDQDPNTLVEYSHFSALGKMQPFTMSITTNCLLLMDFHCHLTTSEVVGYLGGKWDPASQHLSILQAFPCRCRLGDKENAIMVEEEIRQGMMLRGLSLVGWYHSHPHCQADPSLRDVDCQMEYQVAMKGLGATYQPCVGFIVAPFHLTEPIVESTIQAFWVMPPPEHKPHEYGMPMSMNFTAIQDSYLTQDVVNEMKWVSDYYSGAPDFLFFKEPWHQDKTFLEKVKGSLAKKLPKDQVSGQLLDFVQSLLMTQQGQEKQTSR
The following text describes a protein:
Function:
Protein disulfide-isomerase probably involved upon formation of a complex with HHL1 in maintaining photosystem II (PSII) activity under high light by regulating repair and reassembly of PSII complexes.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein. Note=More abundant in stroma-exposed thylakoids.
Domain:
Its sequence is related to the DnaJ family but lacks the J domain. The CR-type-like region is similar to CR-type zinc-fingers and was shown to bind zinc.
Sequence:
MPVSAPSPPRLHSPFIHCPINFTPSSFSARNLRSPSTSYPRIKAELDPNTVVAISVGVASVALGIGIPVFYETQIDNAAKRENTQPCFPCNGTGAQKCRLCVGSGNVTVELGGGEKEVSNCINCDGAGSLTCTTCQGSGVQPRYLDRREFKDDD
The following text describes a protein:
Function:
Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAMASATATLSFKTPSLSLSPPSTRCSAAQGISLTHFNKQLKSTLNLSSSSSISSSKVQPIVLKNKRISTVDSSVSTSSPSFTVFAAKGYKMKTHKASAKRFRVTGKGKIVRRRAGKQHLLAKKNTKRKNRLSKLIQVDRSDYDNVIGALPYLKVNRKV