lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the uptake or utilization of cholesterol (By similarity). Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKQLLIFCLLFGSIFHHGDAGCIMRGLCQKHTENAYGPCVTNDTNVEPTAFDKTHPAYEKMVEFCPHLLTGDNKLCCTPSQAEGLTKQIAQARHILGRCPSCFDNFAKLWCEFTCSPNQQDFVSISEMKPIEKKEGFTPEYQPAEAYVNTVEYRLSTDFAEGMFSSCKDVTFGGQPALRVMCTSTPCTLTNWLEFIGTQNLDLNIPIHTKFLLYDPIKTPPSDRSTYMNVNFTGCDKSARVGWPACSTSECNKEEYANLIDLDDGKTSGQTCNVHGIACLNIFVMLAFIGSLAVLLCVGFVFTSYDEDYTNLRQTQSGEESPKRNRIKRTGAWIHNFMENNARDIGMMAGRNPKSHFFIGCAVLIFCLPGMIYHKESTNVVDMWSSPRSRARQEEMVFNANFGRPQRYQQIMLLSHRDFQSSGKLYGPVFHKDIFEELFDILNAIKNISTQDSDGRTITLDDVCYRPMGPGYDCLIMSPTNYFQGNKEHLDMKSNKEETVSEDDDAFDYFSSEATTDEWMNHMAACIDQPMSQKTKSGLSCMGTYGGPSAPNMVFGKNSTNHQAANSIMMTILVTQRTEPEIQKAELWEKEFLKFCKEYREKSPKVIFSFMAERSITDEIENDAKDEIVTVVIALAFLIGYVTFSLGRYFVCENQLWSILVHSRICLGMLSVIINLLSSFCSWGIFSMFGIHPVKNALVVQFFVVTLLGVCRTFMVVKYYAQQRVSMPYMSPDQCPEIVGMVMAGTMPAMFSSSLGCAFSFFIGGFTDLPAIRTFCLYAGLAVLIDVVLHCTIFLALFVWDTQRELNGKPEFFFPYQIKDLLGAYLIGRQRATDTFMTQFFHFQVAPFLMHRMTRIITGIIFIASFITTVILSSKISVGFDQSMAFTEKSYISTHFRYLDKFFDVGPPVFFTVDGELDWHRPDVQNKFCTFPGCSDTSFGNIMNYAVGHTEQTYLSGEMYNWIDNYLEWISRKSPCCKVYVHDPNTFCSTNRNKSALDDKACRTCMDFDYVANSYPKSSIMYHRPSIEVFYRHLRHFLEDTPNSECVFGGRASFKDAISFTSRGRIQASQFMTFHKKLSISNSSDFIKAMDTARMVSRRLERSIDDTAHVFAYSKIFPFYEQYSTIMPILTTQLFITVVGVFGIICVTLGIDVKGAACAVICQVSNYFHIVAFMYIFNIPVNALSATNLVMSSGILIEFSVNVLKGYACSLRQRAKDRAESTVGSIGPIILSGPVVTMAGSTMFLSGAHLQIITVYFFKLFLITIVSSAVHALIILPILLAFGGSRGHGSSETSTNDNDEQHDACVLSPTAESHISNVEEGILNRPSLLDASHILDPLLKAEGGIDKAIDIITIDRSYPSTPSSLPCTSRMPRAHIEPDLRSL
The following text describes a protein:
Function:
Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
Subcellular Localization:
Early endosome. Recycling endosome. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network membrane. Membrane; Peripheral membrane protein.
Sequence:
MLAAAVSGHQAHCAEARGAGKFLSQTAYFQQSSKRLPQRVIAFPLTPSALGLEGETSLRGGRMPLPPARVPAAQGRPRHVHRRSLAPTCSRTWSRCWPGSRRSARSAGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHATDNTRMELIIPGEQHFYMKAVNAAERQRWLVALGSAKACLADTRTKKEKEISETNESLKTKMSELRLYCDLLMQQVHTIQEFVHHDETCSPPSIENMNEASSLLSATCNTFITTLEECVKIANAKFKPEMFQLPHPDPLVSPVSPSPVQMMKRSISHPGPCYSERDNHSVKEPVSSLHRLSQQRRRTYSDTESYSDTPLEDSQRSAHCPRNAVNGDLVSSTIPEENRSISNERSELEGSLSSFSS
The following text describes a protein:
Function:
May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNVPVAKKRRFKSESCKCKSDHFSSLSSSSNNSKVDLIRRAGPYLIGPMLGPSPVSTIIHCLARKEGTTEFYNLKILTLKNSLMHETPEDRQGKTLLHTEHSLLSLLKDQEGVVKHHGLFQDLAREERSSLLQPNTLEYTGRTYKRLILVLDCLVAHDFDVRTCDSMNLQHYVIKEKKLSEKEALYIFADISRIIENLHQKNIIHRDLKLGNMVINTKSRRITITNFCLGRHLIGENDLMRDQRGSPAYISPDVLSGRPYRGKPSDMWALGVLLYTMLFGQFPFFDNTPQELFRKIRTVDYTIPGDGRVSQSTIHLINGLLKADASSRLTASQVVDSLKTILAFWRNITAEHLQLVPDVDDKQTNDDNNKTNFINNISSDSNINDFNNNDGAKEEKKTNLKNPKKLSLTINTNTTSDGKNNINNAASDGNNFSNSRTAVVESESEFERKLRKVREFPDESGLASSGIFLSRPLKFGYNENGKFAKRAMQYMTTSLFASTLESLSLQQSQQSSSSSFLLHKQGSLSLSSLPSSSSSPSSFTMVRTRSVSSDETSIINNNINNYKNYNNNDNNDCKNGNQLNGDNDCSNSSKKKIIFNISFNIAIDGSKNQNSSSNNNVNNNNNVNNSRSSTYIRNLHGNIFTTPITRLYPGADDDAGGNNNSSSNNIGGHGLTVDDLQIVNNWLSASRTLSS
The following text describes a protein:
Function:
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Sequence:
MQRLVKNFSKMALPARYLPPVHRGITQLDKSVFTRSIPLVVVSFPDPRNISVFSKRFKDEILRVPRVPHVVRLVDSPARVDGLPPLKKQMVANDNHVAKGVLLKDSVHRVEDVKQQLSADAQAFLDECGAAVRDYNYTLDYEFYHADEILRSVLPEEFLDEVPSGFTATGHVAHVNLRTELKPYGSLIGQVILDKNRQIETVVDKVDAIASQFRTFQMNVLAGRPDLVVSQRESNCTFTFDFSKVYWNSRLHTEHERLVRLFEPGQLVADVFAGVGPFAIPAAKKEVLVLANDLNPESFRYLRDNIAANKVDGFVRPKNLDGREFIRSSPALLRDWTAQTGGSVTVAPARRRRGAPPAPPRIVTLPRYFHHYVMNLPDSALSFLNEFAGLYSRHGISEDAAADPAFVLPYIHCHCFEKYSPDEPEPAPADLHARIHRRVLEIMHTSADILPMTALSFHLVRKVAPTKPMFCVTFQLPQSIAFSPLATTT
The following text describes a protein:
Function:
Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (By similarity). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity).
Miscellaneous:
MISCELLANEOUS: Binds phosphatidylserine (PS) in a calcium-independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Membrane, caveola. Note=Localizes in the caveolae in a caveolin-dependent manner.
Domain:
The leucine-zipper domain is essential for its localization in the caveolae.
Sequence:
MGEDAAQAEKFQHPNTDMLQEKPSSPSPMPSSTPSPSLNLGSTEEAIRDNSQVNAVTVHTLLDKLVNMLDAVRENQHNMEQRQINLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVRERLERQCVQVKRLENNHAQLLRRNHFKVLIFQEESEIPASVFVKEPVPSAAEGKEELADENKSLEETLHNVDLSSDDELPRDEEALEDSAEEKMEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTPNHQKASSGKSSPFKVSPLSFGRKKVREGESSVENETKLEDQMQEDREEGSFTEGLSEASLPSGLMEGSAEDAEKSARRGNNSAVGSNADLTIEEDEEEEPVALQQAQQVRYESGYMLNSEEMEEPSEKQVQPAVLHVDQTA
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MEALRSTLEATIDFEGQKLSNLAKTRLLVLGAILSTITGFALGDVMIIWFMFAFVAGITMLLVVPPWPFFTQHPVQWQTPAY
The following text describes a protein:
Function:
Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of threonine and methionine from aspartate.
Sequence:
MAVNIAILGFGTVGTGLPTLLSENKEKLAKILDEEIVISKVLMRDNKAIEKARSQGFNYDFVLNLDDILADSEISIVVELMGRIEPAKTYITQAIEAGKNVVTANKDLLAVHGVELRSLAQKHHVALYYEAAVAGGIPILRTLANSFSSDKITHLLGILNGTSNFMMTKMSEEGWTYDESLAKAQELGYAESDPTNDVDGIDASYKLAILSEFAFGMTLAPDDIAKSGLRSIQKTDVEIAQQFGYVLKLTGEINEVDSGIFAEVSPTFLPKSHPLASVNGVMNAVFIESEGIGDSVFYGAGAGQKPTATSVLADIVRIVKRVKDGTIGKSFNEYARSTSLANPHDIENKYYFSVETPDSTGQLLLLVELFTSENVSFEQVLQQKGNGKRAVVVIISHKINRVQLSAIQDKLNQEKDFKLLNRFKVLGD
The following text describes a protein:
Function:
Transcription factor involved in epidermis differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MSLMKERKPKKPHYIPRPPGKPFKYKCFQCPFTCNEKSHLFNHMKYGLCKNSITVVTDQDRIIKNPKVNSMDQNQTSNEPFAKSSVPAINSSLESKMLHSVAREEAKENLDLKNEPKSHAEKTTVSKEFTLSPPVAISQINKPPSLDGVMRPSAFIPVGEHRVKKGAENRTIPELTSISAEPAKGVHSIKSAFHSLPTPWKSGLVSPDFSQKSSIPRYIRPMISEYPPQFYSEAGLPAVFSPYLFPQTECENPMLSIYSTPDQRPYLPHPLQPSGLPLPKPINAPFEHYRLLQQFQQNPQLHYGFYRPTEHPYFSYGLKVPPAPGLSKEHTSQSMDSPTFIYPSSHPSRLYPLEGFQKLFEIQKETPPVLAKNLDSKSDSESVKMSPRAGSAATGSPERPSPTNFTQSSQGHEGIFDLSTKSISTSDKIGKDFTSGKAMRKSTDSQTIISRENSPSFGNDGVQSHSEGITVTDDAVHDDTIAPLNLSKKSEVESRDIVDTVNNSDFTNERVGFMEMQDLPLNLSVKDSGSNHNTLCADERVLLPRQSTSPPVYQAIQTTDNRAPTTTGIHSLGIIENCDEQKQSAAVALCQLATSSPGVPPRGTEDEFPEKETVVPEQVQPRSPAAQETETDVGARGQKRTNSKELGKSQSSTKKQKAVDSGRMFTLRKRPRVS
The following text describes a protein:
Function:
Regulates planar ovule integument development.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEPSPSSPPSSPPEILDLDSIKALKILGKGATGTVFLAHDVVSTSSSSSPFAVKLVPKSSASSLRRARWEIEVLRRLSVDSNQNPFLPRLLASFESPEYFAWAVPYCSGGDLNVLLHRQNDGVFSSSVIRFYVAEIVCALEHLHTMGIAYRDLKPENILIQQSGHVTLTDFDLSRSLKKPLRPHFYQPDPELIIDRKKSRSFSRLISPTAEKNKTGLKKTRSARVNPINRRKTSFSSGERSNSFVGTDEYVSPEVIRGDGHDFAVDWWALGVLTYEMMYGETPFKGKSKKETFRNVLMKEPEFAGKPNDLTDLIRRLLVKDPNRRLGCHRGAAEIKELAFFAGVRWDLLTEVLRPPFIPLRDDGELTVGGFDIREHFEKLRTTPSSAPPSPLRSPPHVCRKNDPFIEF
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MATHERKTIDLEQGWEFMQKGITKLKNILEGKPEPQFSSEDYMMLYTTIYNMCTQKPPHDYSQQLYEKYRESFEEYITSMVLPSLREKHDEFMLRELVKRWSNHKVMVRWLSRFFHYLDRYFISRRSLPQLSEVGLSCFRDLVYQEIKGKVKSAVISLIDQEREGEQIDRALLKNVLDIFVEIGLTSMDYYENDFEDFLLKDTADYYSIKAQTWILEDSCPDYMLKAEECLKREKERVAHYLHSSSEQKLLEKVQHELLTQYASQLLEKEHSGCHALLRDDKVDDLSRMYRLFSRITRGLEPVSQIFKQHVTNEGTALVKQAEDAASNKKPEKKEIVGLQEQVFVRKIIELHDKYVAYVTDCFQGHTLFHKALKEAFEVFCNKGVSGSSSAELLATFCDNILKKGGSEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKKLARRLLFDKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDLTVARDHQAKFEEFISTHSELNPGIALAVTVLTTGFWPSYKSFDINLPAEMVKCVEVFKEFYQTRTKHRKLTWIYSLGTCNINAKFEAKTIELIVTTYQAALLLLFNGVDRLSYSEIVTQLNLSDDDVVRLLHSLSCAKYKILSKEPNNRSISPNDVFEFNSKFTDKLRRLKIPLPPVDEKKKVVEDVDKDRRYAIDASIVRIMKSRKVLGHQQLVMECVEQLGRMFKPDFKAIKKRIEDLITRDYLERDKDNPNVYRYLA
The following text describes a protein:
Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Miscellaneous:
MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
Subcellular Localization:
Mitochondrion.
Sequence:
MSFGRWAASIGLEIHLQLATVKKLFSPAKVNPLAQPNTCVAYFDVSLPGSMPILNPEALKFAVKGALALNCEVANVCKFDRKHYFYPDLPAGYQITQKEIPIGRNGFIPLSAGLDNVPDTQIPIQHIQLEQDTAKSTSAKNPSRILLDYNRAGTPLLEIVTKPCFHDVNTVSAFLFKLQSIVRFAGISEALMENGGMRCDVNVSIAPVISSENLNELHFKNNGVISVEKSISHFPQLGTQLARVELKNLSNVRNVVNSIRHEVDRQVSLANMGVSWPSETRGFDDITGKTFPLRNKTTSDDYLFLPETDIPPIILSRSYVNSVLKSLPALPDELFQKLTTGSHAISHKEARTLLSVKEYYHYYRNAYHHIDSISHVNQSLKEDALRTLPYWITVELVGKVREIDPSPNINIVPPLQLADIVLLVSKKKLTAASAKLFLRSLIKSPSSKPISTLIQEKNFGTIGDSEKIKACVESVLSKHSKQFEELKNGKTSLIKWFVGLTMRELRGQASPKDIEMEVQSSLRREK
The following text describes a protein:
Function:
May catalyze the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDERHEAAGETSEKPKVLFLLNSYYGPFYDDGDNTGVNVVDLYEAFKVFEENGFDIVIASDTGDYGFDDKSFRDPAIVDETQSIFSNPDCSLMKKLKNIARLDRLNPSDYVIVYIPGGYGCSFDFPHAKVVQDFLYRFYETKGIICAVAQANIALAYTTNSDGQALCTNRRVTGCTWKDEVQNGVLNVMNRLNFYSFGHIAENIGAIFESPPVYVEDPFIVEDGQLFTGSNTNSAKGVAMEAVRAVLNYDG
The following text describes a protein:
Function:
Probable chloride channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MATKNYTVPTLAKWFNSFPHYNLQFLQINNTFSPEESDYQEALGFWAAVPAAWLTVTLFFFLVYFCARCCSNGTARKHPAYCLRWTIGILSLIALTGVAIGLYGNVEANQGVHDFATATESANKTITGVETQVNVMNSGLTDMMSPLDRLRDLVTEIPGAEKIINDTIAEVKKLVSELGTIPFDQEGVNLQLIADDTRFYEYYRFMGTVLLLVLEIVVGLVALCGVGRGSRCLLIFMTCLAFLCLFVCFGGGAVYLAAGVGAGDFCVSPSAYIKDQVKDEVIPKAVLEYYINCHPTSVNPFSQTISRGRDGVSQAKDFLREVEGLTTNLPGAKEIITEIGGKLNTTESSFDELVALVRCQKLNEEYVDALNAVCYDALEGVAYMLVSSLAVGLLFTVSMVLASLAWQRLGRRKQYIEIDEEDPFLPPSGMTPTMNRTSQGPLTLQADIQRGRWDHYLRGGDRGEREPLMRDNRTPPPSYTYAVRDNRDRMQDNQQNPTVEKRQW
The following text describes a protein:
Function:
Probable cell adhesion protein involved in patterning of the nervous system, playing a role in ALM and PLM touch receptor axon growth and VNC axon navigation. By associating with the transmembrane protein sax-7, mediates axonal interactions to establish synaptic connections between the AVG interneuron and the two PHC sensory neurons. Also required for non-neuronal cell migration in the excretory canal, regulating excretory canal elongation and excretory cell morphogenesis. Plays a role in regulating male mating behavior.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Perikaryon. Cell projection, axon. Synapse. Cytoplasm.
Sequence:
MMMLIRCISIFLLFGFVNALIDEASCPIGWQIASDQCVRIVIAPANLKHSKKYCHHEGGELMDTSVTLLLEDVMDLLKNLHENGLSEPTFHVGGMGQALNRTEDGNYKIITINPSSHFPFICSLNKMARRSLLFQQKLLPVGAPQISLTGQSEIYFHPRHDADYIALPCTVQGNPKPTVAWYKNDVEVLSPSMSNVSYLLSGGNLLVPASSTLAYSSFHCTARNSLGEVRSPPILLKPSFIDPFRPHRLDVYSLATGGAKLDCDAPAHQPKSLTYSWLYGSSTDRILSQNERKFISLDGTLFFSYVTAEDEDSYACSLSVYSTQSGHYGPFFRLISSTPKLVNSTFPPKLDSTQPQIFPEDPKVGDSIYLECFAYASPLPQYKWSRVDGKPIPARSHISNYGRVLKIEKVNYGDAGKYKCVAMNAFGSAAGEVHVKLRAPPSILQGLHDRLVPTESNVSFECLLSNADSYSSVEWFKDAKPIVPLLLPAEKRKRLKIDHNVLHLKFADETDSGVYQCVASNDVGSSSSSALLTVKDSAPVFPPNAMSRKVFAAFGSTVSIPCIFEASPRFHGKWADAGGSKLPQKGRIRDEEGVISIEKVLHEDAGLFFCTAHNKLGKAHAQVQLIVVNKPSIKTNFLDEETVNMSCEVELTCENSAECPEALFEWKINDRPAKEYPSLKSKVHEKKSGHKGRHLKQKVDLEVPKSLAGSRQIGRFACSSLYGGSSEFVTKPQLPSPIALTVEQMDEDGKKKKMFRLRWRLPPQHRDTRDHSPKVEGYLVELRTRKNRKWRAAERQLVGNMEKDSITVENLLPNTEYQFRVRSVESAAIGEPSIPSDWVKTAPGAPSETIDNLKWRSLDSQTLLVEWQPIEIGQESSGDNLRYRVSWSEATVGKNATDDMKLSNQDDDFENHLDSDQPQAILKLNTTEGCRMVVLAVRPVNDQGNGSVGTDTIAFLNSHGELKKVSLHNVKPINASHVNISWTWDNTSDCDTKHAVQITCINLSGSEISATVASDRIFWMLGGLEAETAYDCDLKAIDNHGSFGPASKKFRIHTKQHPPSETPLIGKLMMKQMKDTYTTILEWSSIELQKPNRTENGCGYKIFIYISETATEAIELDMPLQRLSDRRNPSARLDGLKLMYMYTIKVAGYNPGGIGPISEPRSIRLGSPGTMDYTTGSSDVPIPSLLLLLLLLLWRL
The following text describes a protein:
Function:
May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Midbody.
Sequence:
MADGSLTGGGLEAAAMAPERTGWAVEQELASLEKGLFQDEDSCSDCSYRDKPGSSLQSFMPEGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFTAEFLEKVLEPSGWRAVWHTNVFKVLVEVTDVDFAALKAVVRLAEPYLCDSQVSTFTMECMKELLDLKEHRLPLQELWVVFDDSGVYDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVPSGLIVDYRNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLKLIENPLLRYVFGYQKNSNIQAKGVRSSGQKITHVVSSTMMAGLLRSLLTDRLCQEPGEEEREIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKGDTFVDCTGADIKISGIKFVQHDAVEGILIVHRGKTTLENCVLQCETTGVTVRTSAEFLMKNSDLYGAKGAGIEIYPGSQCTLSDNGIHHCKEGILIKDFLDEHYDIPKISMVNNIIHNNEGYGVVLVKPTIFSDLQENAEDGTEENKALKIQTSGEPDVAERVDLEELIECATGKMELCARIDPSEQVEGNCEIVNELIAASTQKGQIKKKRLSELGITQADDNLMSQEMFVGIVGNQFKWNGKGSFGTFLF
The following text describes a protein:
Function:
Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol. Shows a very weak activity towards 13-cis-retinol. Has no activity towards steroids.
Miscellaneous:
MISCELLANEOUS: Shows clear specificity for the pro-S hydrogen on C4 of NADPH and the pro-R hydrogen on C15 of retinols.
Sequence:
MAVASVAAALLAALGGALWLAARRFSGPRNQRQQGGGDPGLMHGKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRQELCQAGGAGPDGTDGQLVVKELDLASLRSVRAFCQELLQEEPRLDVLINNAGVFHCPYTKTEDGFEMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGEINFEDLNSEQSYNKSFCYSRSKLANILFTRELARRLEGTNVTVNVLHPGIVRTNLGRHIHIPLLARPLFNLVSWAFFKTPLEGAQTSIYLACSPDVEGVSGRYFGDCKEEELLPKAMDESVARKLWDISEVMVGILK
The following text describes a protein:
Function:
Pore-forming protein that induces lysis of T.cruzi trypomastigotes, bacteria E.coli and human red blood cells. The parasite lysis is much more important than the hemolysis, probably due to difference in membrane composition. Its action on protozoan parasites and bacteria may indicate a role in the control of microorganism growth in the salivary glands.
Miscellaneous:
MISCELLANEOUS: Has an amphipathic alpha-helical structure with positive charges on one side and hydrophobic amino acids on the opposite side.
Subcellular Localization:
Secreted. Target cell membrane.
Sequence:
MSKFWLLLLLVAAFQFAHSYPAAEYELDETTNDEVRQFIGDGYFEDEGDDGDEERFKIKPGKVLDKFGKIVGKVLKQLKKVSAVAKVAMKKGAALLKKMGVKISPLKCEEKTCKSCVIFKIPTENSFCLTIRFMKTNIATYLVVAGEINRKSKFEEKLKLGNMPRCVNVEGFIGKVCMKGIEGHAKSSSGQANVNFCLGLVAEKFGVGAKLCGIYANKKVRVKISPQLFPGATSLDGDIVKLDDNGEDATTLDVDEVEID
The following text describes a protein:
Function:
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MVSHLLGPTKFSEYDDDDEGETSPHTFQRCIVQPLLGGCYIDLPVTIILPNSFCKQLCQTTITSGVIPSSRLPSWSIDDTTKKSVDGGCQGVKATLLRDHTQLVPYPLTSSQLATNTNKYTIMSVEIKPKAGYLATSPFVLPAHRCKYYRTRYSLQQELMEKGHVQKGWNRKNRNILSGSKYCPLDLFSGNLIRTIQAVTEMSLNMQNNFRVWCNGSLMFEEYETPTDQSCQKILNNLFGNNTGMADAKSILLRVIVDIVAKVLINEPVLNNLQQMQMRDVIDGDGATLVYERLVQLCGGSQADAERLLDEARWDLLLQSPPYITSECPYLQQLMNEIQQFQSHLRNTLQAKRVVDEHVADDSHSKCIEYVSQLSKEACIYLLHNWLLSLAMCDVSFFVTFRVLTEAEVNELSHIDGIRESCQTVDTGGIAVCPLEPDLSTKMVVHYEVKCVDCDPKPAKKLHRDGAFKASLLSPPPSKKKAAYSKYEMAIFGMGRNPSKRCA
The following text describes a protein:
Function:
Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Silenced copy of ALPHA2 at HML.
Miscellaneous:
MISCELLANEOUS: There are three genetic loci for mating type genes in S.cerevisiae. MAT is the expression locus that determines the mating type of the cell, whereas HML (containing HMLALPHA1 and HMLALPHA2) and HMR (containing HMRA1 and HMRA2) represent silenced repositories of mating type information. The mating type is determined by the MAT locus, which contains either a copy of HML or of HMR. Diploid cells are usually heterozygous for the MAT locus.
Subcellular Localization:
Nucleus.
Sequence:
MNKIPIKDLLNPQITDEFKSSILDINKKLFSICCNLPKLPESVTTEEEVELRDILGFLSRANKNRKISDEEKKLLQTTSQLTTTITVLLKEMRSIENDRSNYQLTQKNKSADGLVFNVVTQDMINKSTKPYRGHRFTKENVRILESWFAKNIENPYLDTKGLENLMKNTSLSRIQIKNWVSNRRRKEKTITIAPELADLLSGEPLAKKKE
The following text describes a protein:
Function:
Prolyl cis/trans isomerase with specificity for phospho-Ser-Pro bonds.
Sequence:
MRVPQYQFPRVSDNCISRKNPQILCNSQLIPSSISTTKSAKIDSDKKRKKTSISSADRPSDKHKKKSKMSSSSSRSSSGGEKVRASHILIKHQGSRRKASWKDPEGHVISNTTKDAAVSQLKSLREDIVSGKAKFEDVAATHSDCSSAKRGGDLGPFGKGQMQKPFEEATYALKVGEISDIVETDSGVHIIKRTA
The following text describes a protein:
Function:
Required for organization of sarcomeres in body wall muscles and for maintaining normal mitochondrial position in myocytes.
Subcellular Localization:
Cell junction, adherens junction. Cell membrane. Cell junction, focal adhesion. Note=Localizes to adhesion plaques and dense bodies between myocytes. Co-localizes with deb-1 and atn-1 at dense bodies. Predominantly localizes to the membrane-proximal region of dense bodies.
Domain:
SH3 domains 1 and 2 are required for its localization to the cell membrane of dense bodies.
Sequence:
MMHHPHPFGSNLANSSEPQQPSGQYLNPAADAYNFDTFEDSDKFSPKGNVAALRNVIHGQLDMKTPTGNSSRYQKPAPPPVDSTPSWAKNVKVYEPNGYVDPHLNKHNMGRVLDGPVNPNKYFQGVPPASYSQVKHNESKPPVPPSTKPPHSAAQALQAQVLQSSKAPSQPQQSQKTSYRIPYDVALDPRHHLGEFDIDDSASIISSCISTFGESSEIAGFSAAAEQRHLYEQYRKKLMEEKNELKEGSETPCVSLSEKVMTSSTENLKNGNNQQNQQPEPQPPSSSIFNSELTPFGHVAPVAKQFEPTNFPPFSPEKESEIKRSIDLESSQLLVKSKSPAPYSTSSTDHYGTIRRKHKPVAIDLSKSSPNLASQSPSNLFFGASFEEKQNRSPMTSTPSYKEQGFKNDSLNDSLNQAFEIASSIETTKNAYEAPPTPKSASHDRSISDTYPVSSSTTSTWPSHTTTPTTTTAAAPIAAVAPQTYTEQQPMSTSMSSSVMSTNMDEPIVVGSHQQIPQQSPDSSPERNEDMSQWYRKMFKQMHRKGEDGSNEGKEQHFINPSNVTDGIGRTTPTASNLGRSRENLSFNQHRPDHPSSYFDSLEHGPNDQYNNQERVKQSNEEELLRLKAEKLAEELRKEKERKHSFIPSSAPSLQNNMDRLNSLLYDFSSDIQEPAHRDYTPQPVMTATAVYKFEPRSARELPLNRGDIIRIIREVDGYWMEGERNGRSGIFPTSYVQINTGNQGDSQKMRAIYPFTARSDTELSLKRGEIITRRRQIDSNWLEGSNQIGIVGIFPASYVEPIEQVEQHIPTIVPNRPKTPKIEDQVYNQVYKPNETVIMQSNQGYYDKAAVVPNNKVRFDLPSGSDSNLQMSLNPHQNQFPPTHTQTSTQQPSNYGMKKIEYEREKVVEEVPPMHMDQYRKLNDEPKNPKKDTNILMNAASLIPKGSEMYRAVYPYQPQKEDELQLYTNDIIFVVEKCDDGWFIGTSLRTGDFGIFPGNYVKRH
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTSLDRQLKSIKEKIHYVDVTKKRASLLFNEVEAANIDLDAVLAMGQEGLEELINIDVRFKCFQLTLFADTSKTFNRVLEVKEENDKIDIEINKFLELQSNYFLSNSAHKALEWLIRRYRINEFNIDSVLSSIIPYHESNIFAKFLSILQFEFNKKWEFLTNVQENKVYIPREYFIKITGSHPFFLDFILSTVETYDRNNLVTKPLVSFFTAFLIELLTVKTTPHLKETLACLLKCLKSNNTDLLLGTLYDFNSAFTFLMVLFQKQKFDSLSNSTLELLVSIPALFEILFDFHSQEKSLDRLLLILFKYLSSNIVESAECYTLLSQLITDLPNTQQYHSIIFNKIISTYILKNKQEKEESDESIISIARLLNNQIVQEEIEKLIKQQNNNKDKLVNFQKLIFEQKTISTSQQNTIFLKLESTIPSERKDGLQLFKQLYSEESDKSTLISTLSSSFSDTIYSRLVDSDHSVAKDAWALPKLYQIVVSKDLIKASNQFFKNSSFTNDDKLVEIVLLNLLNVVKQQQSTTSDILAVLFSQLFNESVSSLIISKFNKELNPIFNNVTTNKNKIETVIKSISNNINSEQSLSLLVSVSKSTYSTFNSDLFLLLLIQSVKQQYQQQSFKLAIEVTQRYINNDSSKETQMNQFNNIQDIYTAIKGSSAVTKPIQIGSISHVLCLIIENLQTIQAESLIKELSSNAAITSTVTTANASSIVQLIQSLCKLIFNSKVSNIDSVLKVIIKKFFSNQLVFFKFLSNFWQQPVTDFNSVYQSLCLSGFLVNSKAFSRYILSNQTIIVPFISLLKSNESSIRSTSLESIQEIYNQIKTTTASASKNSKSDSSIQFYAGENKPTIDLELLSKFLLKLTQYKKEFSMDKEFLDSYFSKVLFNPSNTIAADEDDEDEDSSDEETNKAGTNNTDKFTLDEVKTIGKFLVSSSLNIESIESKLSFISSLQSVDDVAFVETTSEYLQALLEKAKNKTLVQTESKILDILLKKLGSSAVLNSSKLKKSHNVFSLFLSALSISNDIEFTNTKTKYSPLRVAIASITKNLLLTIPIKEQINIVEIVLSYFFSENQQVKDVAKNALLSVLVDGTVILPMLLPEKETKSSTPAASLPIPRYNSLFELIRLNSSKIGNVSVLINPIQLILKKLDVNTVATGEVTVDAIEYCKQLAMASLGSICEQSTSAKDIKSIEGLYDISIIIKCVESTKSLQTCNSALLLLSNLASKFPQKLFKFMDSIIGMIKFVLENGDDNFSFMILQKFLSQLLPSLVKQGISLASIFKLFLESFATIPKSFRLQLFNSVCQSVSYSQFHILLCLILIKKIQDLRIITKKLKPLDKDTIMSSDDQIKEEVDYDQFNDFVSVFCDQVPVLEMSTSLANLCLLLNQLSIETGSCIEPLSEEEEIVYRLLSNNNSKDNRLLQVNTLDFICERLSSKVYLDSFSVSSAQERQTIENQYLLAFENLLVLLKKTTEYSEKTIVSTNQIKLNGSNNSIINQVGKDKFIKKILSSINLCMDRLSQLLSVPGFISTITQLLEHSDSNVRRRSLVIFNEKITLIKEDIEQEQVDQFLCLIDSFARILESSTETEANKQTALLSFEILARNFSSSNPTVFLSQIPIIIKSMGHSSHQVVSSSLICIATLCSELQAKTIPYIPQFFPVLLNTLTGSYKTNHLQEENETRTLLQISCISSLEMMLNTISKFLSPYLPQLLNALLHPRLTSNSLLSGKLLAQIKRLLSLLTKNVEFRLLLPAMFTAYEFAVQSENDQSLICLFDFVGEISLNLGPKDIALHHKSIFKFYLQCFEFRKKYKDRVKNADKIEDHIISSFMTLVMKLNENLFKPLFIKVLDWALTPQQQQQNGNHHDEESEEDDNSDSEEEQVSNKKKKVMNGKSKPVQQQEKSKDNLLFFYKIVNSLSSNLKTIFVPYFGYFLDDSIRQLQSIFNNTPLKNNNNIIVNETNNINKRKLLNNNNNINNNINNINNNNIEESILCFVISALEKCFMYDTDGFLDKQKFEQVLPALANQLENQMGTIESYNNRVKHYLAPCITQLAVAINQDLLWKHLNHTILMKTRSPYSIVRYSAMVVINSLHRRMGEQLLILLPETIPFISELLEDSVPDVERITQETIKEIEKHLGSDESIKSYL
The following text describes a protein:
Function:
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Sequence:
MYFAVIGAHVRGKSASPAMHTASFKALGINAVYIAVDVPKEELGCFAQIARLNFRGFNVTIPHKEEVVKFLDALSAEARAIGAVNTVLVERNLMVGYNTDAHAVYKLAGGHMEGAEVLILGAGGAARAALFAAIKAGAKKIYVKNRTAERAEALAREFREKFERPIEAIPWSGAVKADVVINATPIHDAVIADLTGASLYVEFVYTPTPRTKMVEEAERLGVKVVDGVDLLVEQGAQAEKIWLGVEPDRAVMKKAVLEFLGL
The following text describes a protein:
Function:
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity).
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm.
Sequence:
MVAMLFYVDTLPDTGAVAVVDGDEGFHAATVRRIRPGEQLVLGDGVGRLARCVVEQAGRGGLRARVLRRWSVPPVRPPVTVVQALPKSERSELAIELATEAGADAFLAWQAARCVANWDGARVDKGLRRWRAVVRSAARQSRRARIPPVDGVLSTPMLVQRVREEVAAGAAVLVLHEEATERIVDIAAAQAGSLMLVVGPEGGIAPDELAALTDAGAVAVRLGPTVLRTSTAAAVALGAVGVLTSRWDASASDCEYCDVTRR
The following text describes a protein:
Function:
Plays a role in the inhibition of host innate immune response. Within the host nucleus, inhibits activation of interferon-beta promoter by inhibiting IRF3 activation.
Subcellular Localization:
Host nucleus.
Sequence:
MTSSAMDNNEPKVLEMVYDATILPEGSSMDPNIMDCINRHINMCIQRTYSSSIIAILDRFLMMNKDELNNTQCHIIKEFMTYEQMAIDHYGGYVNAILYQIRKRPNQHHTIDLFKRIKRTRYDTFKVDPVEFVKKVIGFVSILNKYKPVYSYVLYENVLYDEFKCFINYVETKYF
The following text describes a protein:
Function:
Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and is required for the proper accumulation of rpa1/nuc1 at rDNAs. Required for nucleolar localization of condensin.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MNDSEEELEQQGSQEDISSSQDTSDEKEMRKQDALYAQLIEYREIVSELRRSEMKNLCIQLYCSYKAGITRRNELQSDLDGYERRIPPRLRAVWPTIHSIPDESFFDGTSASRFRQEAAYLAVRLASKKLHKLGRMASSEELPNPDGLRYLVERLQIKLERLFDSVDTFRQEQGSKSMQSRVKPMDWKILYGLARVTNGSFSSSQKADVLALGNGTRACQSLFKEMSLQPSIDIEKVSHSNPEISIEFED