lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Sequence:
MVKRSCPSCGLEAGSEKKERGNPISVQLFPPELVEHIVSFLPVKDLVALGQTCHYFHEVCDAEGVWRRICRRLSPRIRDQSSGARPWKRAAILNYTKGLYFQAFGGRRRCLSKSVAPMLAHGYRRFLPTKDHVFILDYVGTLFFLKNALVSSTLGQIQWKRACRYVVLCRGAKDFASDPRCDTVYRKYLYVLATREQPAVVGTTGSRACDCVEVYLQSSGQRVFKMTFHHSMSFKQIVLVGQETQRALLLLTEEGKIYSLVVNETQLDQPRSYTVQLALRKVSRCLPHLRVTCMASNQSSTLYITGGTLIPRKQVPKAAELRAPDPPDQGGVYFEVHTPGVYRDLFGTLQAFDPLDHQMPLALSLPAKVLFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVHYLQRPIALWCGLNHSLVLSQTSDFSKELLGCGCGAGGRLPGWPKGSASFVKLHIKVPLCACSLCSTRECLYMLSSHDIEQCPVYRDLPASRVGGSPEPSQGAGAPQDPGGTAQACEEYLSQIHSCPTLQDRMEKMKEIVGWMPLMAAQKDFFWEALDMLQRAAGGAGPDTSTPES
The following text describes a protein:
Function:
Forms chloride channels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane.
Sequence:
MSIFAVAMTISYQTGFFHLIFRWYGSIWRSIYKELTVYLVLFFSIRLFHTLAIPWLDGDGEKNMKVRFEAICRQFDNYTKLIPLTFLLGFYVSNVVSRWWRQFECLNWPEDLLSLLCVCVKDKDGTDDRAHRVRHRIARYLNAKEECPYTRWMTPLHWVQQIMANEVANHDMQVTYLTNFMSELKNFRASFRRLFCHDWVCVPLVYTQVAAIATYGFFFFALFGRQNINQNDVDTIFPIFTVVQFLFFVGWYKVGLDLMRPFGLDDDDIELAYILERNINVSFAIVGKLQKQPPPPYEEDKFLNSDVRIELHSLTSDKTNQKFRGPKLNTYDQLVDLEQSMEEGYEENGRGQKEKMGSFMDVAEKVIKEERRARVTHGLNKWLPTWKEDIPKEKKMFYW
The following text describes a protein:
Function:
NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.
Subcellular Localization:
Mitochondrion outer membrane.
Sequence:
MARQTLLSTPLHGVFIPAFLIVFGAYIIKREWVGYAFILAVSLGFLKFWRGRTRKVLSNEYRSFELSDKAVLNHNTAIYRFRLPRPNDVLGLPVGQHITIAVDVDGREYSRAYTPLTSDSERGYFDLLVKSYPNGKVSKRFAELKIGDTIRVRGPKGQMSYKCGMVKHFGMIAGGTGITPMLQIIRAVLSNPDDKTELTLLYANVCEDDILLREEIERLCKRDSRLKVHHILNDPPKDWEGSVGFVTKELIKHHFPEPSPDTKVLICGPKPMVDAMREATLALGYEKSRAISKMADQVFVF
The following text describes a protein:
Function:
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.
Subcellular Localization:
Nucleus. Mitochondrion.
Sequence:
MPKPGFYAVRFGRRPGVYITWAECQQQVHMFPGAVFKKFGTYDEASLWASLRPQTPPPPETSETDRKDGLKESDKGKRISDSADPSAQHGPRSSSKASPSHPLHLPYQQDCKRERSEDTDDTESPGRKAKAGKHDRNEDKNGYDGFTAMDDYISVLPPDDEAGQSSSTQVDGNITTAELPAVGGEPELSSQQSEILAKIMNGENFFFTGSAGTGKSVLLRAIIKAFKEKEGEREQREATRSFRSWQGYRGAQKAEKEEVVKWSLAVTASTGMAGVNIGGTTIHSWAGIGLGVDNAEKLANKVRANALSRKRWRTTAALVIDEISMIDAPLLDKLDHIGRIVRNDDRPFGGIQLILTGDFFQLPPVTKGQIPQFAFEAKCWPKLFSHKNIKTLTRVFRQRDDRFINMLEAMRRGTITPDDTVLLQSLNRPIEYPDNIEPVALYPQKRDVEFVNSARLDALPGAVTLYDCHDEPGFTAGGFPISRTEATIKLNKNTIWPQHLSLKEGAQVMLVTNMGDGVLVNGSTGTVVDFLTIPDAIKRGIHLPEAAIKGQTSMDLEFPVVAFAQSKFARKKVPERVIIPSMSVDMLNALGQPEATRYQIPLILAWALTIHKSQGQTLERVKIDLAKIFVEGQTYVAISRAVSLDSLEVLNFRPHSVKAHSKVIDWARPYEEEQAAEEEWNNLEDNIGILY
The following text describes a protein:
Function:
GTPase that plays an essential role in the late steps of ribosome biogenesis.
Sequence:
MALPTIAIVGRPNVGKSTLFNRIAGERISIVEDVEGVTRDRIYATGEWLNRSFSMIDTGGIDDVDAPFMEQIKHQAEIAMEEADVIVFVVSGKEGITDADEYVARKLYKTHKPVILAVNKVDNPEMRNDIYDFYALGLGEPLPISSVHGIGTGDVLDAIVENLPNEYEEENPDVIKFSLIGRPNVGKSSLINAILGEDRVIASPVAGTTRDAIDTHFTDTDGQEFTMIDTAGMRKSGKVYENTEKYSVMRAMRAIDRSDVVLMVINAEEGIREYDKRIAGFAHEAGKGMIIVVNKWDTLEKDNHTMKNWEEDIREQFQYLPYAPIIFVSALTKQRLHKLPEMIKQISESQNTRIPSAVLNDVIMDAIAINPTPTDKGKRLKIFYATQVATKPPTFVIFVNEEELMHFSYLRFLENQIRKAFVFEGTPIHLIARKRK
The following text describes a protein:
Function:
Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.
Subcellular Localization:
Nucleus.
Sequence:
MEKTRGVEETPSSEPMEEEEEEEDDLELFGGYDSFRSYNSSAGSESSSYLEESSEAENEDREAGELPTSPLHLLSPGTPRSLDGSGSEPAVCEMCGIVGTREAFFSKTKRFCSVSCSRSYSSNSKKASILARLQGKPPTKKAKVLHKAAWSAKIGAFLHSQGTGQLADGTPTGQDALVLGFDWGKFLKDHSYKAAPVSCFKHVPLYDQWEDVMKGMKVEVLNSDAVLPSRVYWIASVIQAAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTDWKGYLMKRLVGSRTLPVDFHIKMVESMKYPFRQGMRLEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIKLSERRSDMAHHPTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLEAIDPLNLGNICVATICKVLLDGYLMICVDGGPSTDGSDWFCYHASSHAIFPATFCQKNDIELTPPKGYESHTFSWDTYLEKTKSKAAPSRLFNMDCPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQPPVAAEPTTPLKAKEATKKKKKQFGKKRKRIPPTKTRPLRQGSRKPLLEDDLQATEKSSSDPVPEESKSLPGGVKTGPACSSAQRRPASFPTWAQKRRVKCEGTLPGTKQSSLDHWAWRASQTPAPNSERSRASPAGPSPSLLPAPRGEGATPTSPPRPEGPRS
The following text describes a protein:
Function:
Probable methyltransferase.
Sequence:
MNLLQLGKLHENVLDAGCEPNRNARYLASLGYKVVGIDISERAISKAIDKTSSEKSNVNFNQRDFSRLNEFKGHFDTVIDIGCFHSILNSDHEPYTASLSHICHSDSSVFLRAFSETNKSRYRRWQGHKRYSLALKRNNVKKLSL
The following text describes a protein:
Function:
Non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. The channel pore can dilate to provide permeability to larger cations. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasm. Lysosome.
Sequence:
MKAHPKEMVPLMGKRVAAPSGNPAVLPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTSPPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNISPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAAVLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIREKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAVPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFVQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFEEIEEFPETSV
The following text describes a protein:
Function:
Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.
Sequence:
MQETSRDRTSRSDGRAFLPAGMGGLWRPGLRPVVFCGWRWSHPGSPTRVAERVEPCLRPGRSGTGGAETGLRRLGTWKRPSLAGELTVQPPRRPKSTNPYTRAQEEDWRRRNKTVLTYVAAAAVGMLGASYAAVPLYRLYCQINYPKTRILATSSIRRMMTLETTGLGGSAVAGHASDQIANMVPVKDRIIKVTFNADVHASLQWNFRPQQTEIYVVPGETALAFYKAKNPTDKPVIGISTYNVVPFEAGQYFNKIQCFCFEEQRLNPQEEVDMPVFFYIDPEFAEDPRMVNVDLITLSYTFFEAKEGYKLPVPGYN
The following text describes a protein:
Function:
Acts in signal transduction. Activates CDC42, RHO1 and RHO2. Negatively regulates 1,3-beta-glucan synthesis. May be responsible for the down-regulation of CDC42 during mating.
Miscellaneous:
MISCELLANEOUS: Present with 468 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Bud. Bud neck. Note=Localized to the bud site during bud formation and at the bud neck during cytokinesis.
Sequence:
MIQNSAGYRSLNTASPMTVQVKNQKKICARCNKLVIPDSQRTKTTLKALGKYYHESCFTCQDCQKPLKPKYFPYQVDKTSESILLCQYDYFRRHNLLCHVCDTPLRGLYYTAFGYRYDEEHFSCTICATPCGVKKCFMYGNQLYCKYHFLKYFSKRCKGCEFPISDQYIEFPKGEEIHCWHPECYGIHKYWHVNLAAETVGLQYLPKLEYNPNSGDKDINPTAYELDKQMQAFNFILSKTWSVLYRFEEEAASCISDMFQYLTSNDQLKGIESTGLLVLKIDCLFRGLDTLNLSTNKSMPVNSDQECIENNAMAASKYSKFPKNLSTKIMIYLQLLRKLGTENKNETITISSFMSVITGLAHFLKLLTRFGLYTALENNKLTHSVNPLLRFLREVEKNELFENNPFQYIKTPVNATDSCAGCNKYIQEECIQFYEHRWHIACFTCSSCHKNINPRSLTDPTFNKEKKKILCSHCSIDDPASVPGFKFVTKLAQLIFLLKIALVKSRTVMLKSKASNKVGRNSLQSTMLKEQTYIRTLNDIKRLRSRRESVRVTHNKQQARKSVILETAETDLNDPTKQGDSKNLVIQTDDPSSSQQVSTRENVFSNTKTLTLDDISRIVAAEQARELRPNAFAHFKKLKETDDETSNVVPKKSGVYYSELSTMELSMIRAISLSLLAGKQLISKTDPNYTSLVSMVFSNEKQVTGSFWNRMKIMMSMEPKKPITKTVFGAPLDVLCEKWGVDSDLGVGPVKIRIPIIIDELISSLRQMDMSVEGIFRKNGNIRRLRELTANIDSNPTEAPDFSKENAIQLSALLKKFIRELPQPILSTDLYELWIKAAKIDLEDEKQRVILLIYSLLPTYNRNLLEALLSFLHWTSSFSYIENEMGSKMDIHNLSTVITPNILYLRHKEISNDNVPDEPESGLVDSFAQNKGENYFLAIEIVDYLITHNEEMAMVPKFLMNLLKDVQLQKLDNYESINHFISTVMQSKTIDYSECDIKTPVTVKDSTTTVIQGEINK
The following text describes a protein:
Function:
Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity.
Subcellular Localization:
Cell projection, ruffle membrane. Cytoplasm.
Sequence:
MFSRKKRELMKTPSISKKNRAGSPSPQPSGELPRKDGADAVFPGPSLEPPAGSSGIKATGTLKRPTSLSRHASAAGFPLSGAASWTLGRSHRSPLTAASPGELSTEGAGPDVVEDISHLLADVARFAEGLEKLKECVLRDDLLEARRPRAHECLGEALRVMHQIISKYPLLNTVETLTAAGTLIAKVKAFHYESNNDLEKQEFEKALETIAVAFSSTVSEFLMGEVDSSTLLAVPPGDSSQSMESLYGPGSEGTPPSLDDCDAGCLPAEEVDVLLQRCEGGVDAALLYAKNMAKYMKDLISYLEKRTTLEMEFAKGLQKIAHNCRQSVMQEPHMPLLSIYSLALEQDLEFGHGMVQAVGTLQTQTFMQPLTLRRLEHEKRRKEIKEAWHRAQRKLQEAESNLRKAKQGYTQRCEDHDKARFLVAKAEEEQAGTALGAGSTATKTLDKRRRLEEEAKNKAEEAMATYRTCVADAKTQKQELEDTKVTALRQIQEVIRQSDQTIKSATISYYQMMHMQTAPLPVHFQMLCESSKLYDPGQQYASHVRQLQRDQEPDVHYDFEPHVSANAWSPVMRARKSSFNVSDVARPEAAGSPPEEGGCTEGTPAKDHRAGRGHQVHKSWPLSISDSDSGLDPGPGAGDFKKFERTSSSGTMSSTEELVDPDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCLETLAIQCGHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVAMAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAEDGCRESRVVSNDSDSDLEEASELLSSSEASALRRLSFLEQQQSEASLEAASGSHSGSEEQLEATAREDGDRDEDGPAQQLSGFNTNQSNNVLQTPLPPVRLRGGRMTLGSCRQRQPEFV
The following text describes a protein:
Function:
Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAVCGKEYTSGWKYPTILLCLFGFFADMRAVDPFTAQYFTGSYHNLTVEQVKNSVLPVWTYSYIALLIPVFLLTDYLRYKPIIVLQALGLSISMLLMLITRGEAAMQGMEFAYAIFSSCDVAYYSYIYSMVDIVYYQRVTSYCRSITLVAATLGALLQQILMSFAGVSYFYLNILTLTSALVSLVCSMFLPVPSRSMFFHKKMPGDTILSKQARSPKMETTEDTNMLKGCEAERASNTNFFNVIWLLCKEVKECYWSRKILYWSLWWAFATPIYNLLVNYSQLLWVYVEPSGKINAYNSAVDAASTFLGAILSMGAGFVKVDCELFGEAALTCLSIIDAGVLLFMGFSRTVWISYAGYLIFKSSYMLLITIATFNIAVNLSMERYALLFGFNTLVALFIQTLLTVVVDHRRLGLDLITQFLVYGSYFSVVAVMFMLWTTYLLMSHYCKSPGSDLHSTITAMSQGYGLNSPTAGSGASHKVSDEPSVGQ
The following text describes a protein:
Function:
Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
Subcellular Localization:
Cytoplasm.
Sequence:
MAEVSEEIRNLAARHQELQRQAEALRQEMGMIQTSISSCDQTIVTINELKAASEAGKPAETMVPVGFGSYVYAEVKNPDRIIVNLGAEFSAEETAEEAIETLNRRKEQLTKILEQMNASLTRLTQGMQTLEAEAAKLQPGQA
The following text describes a protein:
Function:
Involved in spliceosome maturation and the first step of pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSNKNRFSRSFGGRSDDESEDEETRQPQFITGFGEEGIEYKDEEFQRKEREKAKPKVIPVPSSSHWLQERIQKRDEGREGNERIEGKNNGNDKSNASPKPPSVKYGLNLPSASTTHVVIKQTTLKQQTTLTQKDIPETSTGVAETVSQETTTTTRVEESTRQQQQQQQQQQQQLPAEVRLVLEETKRENDPLARSDSGKVISVASTKSPSPEDSAAALFKKQMGELPSASQVEEYAEMPVEEFGAAMLRGMGWNNEYSAKDAFDVNRRPTFLGMGAKPLEEEIPELGSWGKKNPRKQMYIPLRKRPSEMGRTQTEEDGRRRGESSRERNHDRSRSGSYERERERNREHDERDRHSYRRSHRSHRSHRSYREENREERHSSYHSRRIR
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MPSLSNKWKIKEPTEGVPVPIPKCPPIMIHRRTEIHEEILHLTLEIIYWLTGEDCTVVQTPNGVSPAHRPLGLERLTLINNQSAPVDKEELILKLANRIICLLTREVPVRYEDTSVHFSEEEWEYVERHKELYRTVTLHSPHSGASPDLDTTTPIEYETCATSPDSINKSGSTKSKEISYLAPDKPENSSIQDEGISILSVDCKSVGPSDFLQDKSESSSIKYEVEADLVLDRPINSNGAYEVVSDMAQDKPGGSSITSEGAPKEKLEISTPPNDKVSKLNKRVKRLSQCAVETADKVTLCQGGNLMHSDSYTFTTPAQSAPLPFYPVLYVINKGIAVPTPVGSEIPLSCPECQACFATSTDLGEHQCIHKQDELTCADCGKCFVNRSRFVRHQRYHKPEKFIICVECGKSFWHKSNLTAHQRIHTGEKPFTCSDCGKSFATNSQVLRHRRIHTGERPFACLECGKCFTTSSNLVDHQTIHTGVKPFACSECGKYFRSKRYLYRHLQAHTVKAGVV
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEQQQPQQQNDGQQQQQQQQQHQQQQQQQQQQQQQQQQSEQERIYNKKQEHLPLLQTVEELVEELRRSLIVVEEFQTPSQQLLFDKLNKIINLYEKIESNRHIVNDVEIPLEIFRVIDQSKNPDLYVKETLQNCLSANEKTKGKIESIKNFKKELESHISESFASEYAEYKLLTQKKETQEQQNDDQIKVDDSNNNNNNNNNNNYNNNNNNNNNNINNN
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MTTVEENLFFMQLQAAELRLWTNEWDDDELAFQLQIEEALRFSMETWIGSTSKASVHKCCTTGVLSETGFISQAGVPDDHKTAFLEQKLEVESLQQVVDDEAEALREQARLEELRAICDHDAKFVRHLSSPSIPDTRKDHLENPFTFHSDGLKGTLDEAWGLEVIMASMNLTHATDVATSSQEAGSEVDDDDRTCKICQTTTMNLSNSCRVTPKCGHRFCAACLRSHGTATVKNGRFQIPCLDYMCGEMWPTKLCELLLSPDDVSTLHQREVEAALPELDRVYCPFKDCSALNLKPDVGEPSSSWQAANTGAECVTCHRYFCFTCQVPWHSEQTCEEYQRTPVDERSGSDIALLKALAKQKKWQTCVCGHVVELAYGCNHITCRCGKHFCYICGEDFRHGHVCQEDSRR
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MSKKSENQPCMVCGEISYSIRFGAVSCRACAEFFRRKIVSKARIPKRCNGACDLGKYHRKTCQSCRFQKCLKIGMLEKVVASRTPVNRRSENNQTILSGLEKAYDKLENSRDNVFDRKNKIPKYCNHQELDDMFEIDIKLISTHFIQFFESKSSLENNQNKVLSTHFIIRFSLLEVAFRAFGKPTYILPNNDIIDVSKLDKVYQHLETGEDERGKNSQVILQRFWQMNEKTMKTEVFPVNLDQSEFLFLCALIYWDFGIENQSEKCLEECQRMRTQVLKELTEYEKSNYPENELRVAQVIGILQALQKTLDVIQHSGYISNVYNLKGKQCPLYEATNE
The following text describes a protein:
Function:
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity).
Sequence:
MRIKRLPESLVRKIAAGEVIHNPSFVLKELVENSLDAQADRIVVEIENGGKNMVRVSDNGIGMTREEALLAIEPYTTSKIESEEDLHRIRTYGFRGEALASIVQVSRAKIVTKTEKDALATQLMIAGGKVEEISETHRDTGTTVEVRDLFFNLPVRRKSLKSSAIELRMCREMFERFVLVRNDVDFVFTSDGKIVHSFPRTQNIFERALLILEDLRKGYITFEEELSGLRIKGIVSSREVTRSSRTGEYFYVNGRFVVSEELHEVLMKVYDLPKRSYPVAVLFIEVNPEELDVNIHPSKIVVKFLNEEKVKKSLEETLKRNLARKWYRSVAYEEISSRALSVAEAPSHRWFLVKGKYAVVEVEDGLLFVDLHALHERTIYEEILSKKSWGKRRVKRNITVVLSREEKQKLEEYGFSFQGEEGALKVIEIPEFLTEDVVEEFFRDFPVDEKLKERIALAACKLATKSGEFDEEIASKLLDVFFKKRFERCPHGRPISFKISYEDMDRFFER
The following text describes a protein:
Function:
May function as a co-chaperone.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAVKKQKSLLIAYILLIFGGIIGLHHFYLGRDRHAFLYWSTLGGLFGLGCLRDLWRLPTYVRDANEDDFDKPSKPSNRKKKEVKGSASNRKQNEVKGPPFVFVRLVAQVSVAYVYGLITSMIVPLDNQFHYYVSFLFLAIGEAIAIFTVANVGRHKLAIKPALYISILAVFFNVICFGHENHSQIIFLTALIASPAASMCTTYKTPNEFKCHRGVFRRWLILALAGTLYITAISISIYHHGEVTSEDGERIKVKDAVDHFFSSPLWLEFKEVLYAIYQEGKQNGWWHVWIELNKALDPEGESNALKVLGLSMQATDAEIRRQYKKLILKWHPDKNPNNLRESEQKSIEINKAYEILSKVRNRRKLKANSSAS
The following text describes a protein:
Function:
Meiosis-specific cyclin. Required for normal homolog synapsis and recombination in early to mid-prophase 1.
Sequence:
MPPTMLASVPTRPRSHPFRRRRGAAAAAPPLLPDQIAAAAAAAAKRPAESSTSASSCFHSEVISATSTTCPTSLAAAQRPEKRPRYQDVDEEQPAASECSEIIGGARPRAAEVEVSESSCLASVLESYLACPEQLANDAETTAYSSAREDLTLSETEEEEEEEEVRSGPCICTDCSFSPLHESSSSSDDDNAVPSPTFSLFLALAEQFVPFTHPKTPTATDVALQAGEGKRFEDLDNEVSYERFRRRERRGVVARDYIEVYSSMLGSYGRAVVEQRVVMVNWIMEHSQAMKLQPETVFMGIGLMDRFLTRGYVKGSRNLQLLGIACTTLATRIEENQPYNCILQKAFKVGINTYSRSEVVAMEWLVQEVLDFQCFVTTTHHFLWFYLKAANADDRVEDLAKYLALLSLLDHKHLSFWPSTVAAAVVALACLATNNESSCHLVMETHMRTKNDDLPECLMSLEWLTNYAS
The following text describes a protein:
Function:
Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MNTLLSRANSLFAFTLSVMAALTLGCILTTAFKDRSAPVRLHVSRILLKKVEDFTGPRKKSDLGFITFHISADLEKTFDWNVKQLFLYLSAEYSTKSNAVNQVVLWDKILLRGENPKLNLKDVKSKYFFFDDGHGLKGNRNVTLTLSWQVIPIAGILPLVTGSGRVSVPFPDSYEIATTF
The following text describes a protein:
Function:
Essential for the assembly of the distal half of centrioles, required for centriole elongation. Acts as a negative regulator of centriole elongation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MSSDEGERNSPDLPRDSDRGSSVSSALQDEYEELLRYAVVTPKNDPSLPSQLLNTTQLTKNPQHTPKRDTAAQLLADNEGQLNIRATPTPLLEESRPPSRMSEAEIMSARSVLSEERSARVQTGSDRSQQSSPDALITTTTEIFISEDNLNRMENILDTWSTTLKSNVMMELRKWKLAFVEQHRLELKKEREKHAAQMTAVNAEMDSLKDLLNTYQISNQRKDEVIVNLSRAVDRQRQKLELMRSFTQWRMRQSAAREETQGSRLAEQHYHMQLKRKVWSGWHSLIQNRWRERVERACCARAEDVCMQLSTDYEAKMAQHVEELQKAQAEIHRLHMERERYEDSMKKAFMRGVCALNIEALSMFNTGEATRLDRDGPPQRDEPSTSSTTNLPPRNASSARLSPIVMESPILGPSHSNPEDVEPEQFFSQPSSSTGPRVETLVSTTVVNSTGPPGGSIHPFRQANSRIVTAGKQKASKTVTARLTGRVEHRTSRPPAAMHVMGVAPPMSSVVVERHHPVTQLTVGQATAAKFPRPAPQSQTVSSSKSSSSQTRGTSSSFHLHSIKVVD
The following text describes a protein:
Function:
Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.
Subcellular Localization:
Lysosome.
Sequence:
MLTPRSLAFVAVIQLIPLHHGDGRLHVLRTETDDTNRTADPSVEAAFEQYVKRYNKTYASGSAEYSKRLNAFRDALIRIEDRNRHGNHSNGALYGLTPYSDLTPDEFRALLATFAPAENTRTEANEVEHDDLQLALPGATSPRYPPKFDWRTRGVVTAVRNQRDCGACWAFSTVETVETMHALAAGTLTGFSVQQMIDCSNNSNHGCNGGDTCAALKWLKVNRIKLVRDSVYPFKAVTGSCQHPASDVTAEVSDYTCDRLVGNEERMIDMLANVGPLVVAVDATTWQDYLGGVIQFHCDAGRNHAVQIVGYDLTGDVPYYIVRNSWGKQFGNDGYLYIAVGKNLCGIAEEVSTVRVKNPAGGI
The following text describes a protein:
Function:
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTSTRQAGEATEASVRWRAVLLAAVAACAACGLVYELALLTLAASLNGGGIVATSLIVAGYIAALGAGALLIKPLLAHAAIAFIAVEAVLGIIGGLSAAALYAAFAFLDELDGSTLVLAVGTALIGGLVGAEVPLLMTLLQRGRVAGAADAGRTLANLNAADYLGALVGGLAWPFLLLPQLGMIRGAAVTGIVNLAAAGVVSIFLLRHVVSGRQLVTALCALAAALGLIATLLVHSHDIETTGRQQLYADPIIAYRHSAYQEIVVTRRGDDLRLYLDGGLQFCTRDEYRYTESLVYPAVSDGARSVLVLGGGDGLAARELLRQPGIEQIVQVELDPAVIELARTTLRDVNAGSLDNPRVHVVIDDAMSWLRGAAVPPAGFDAVIVDLRDPDTPVLGRLYSTEFYALAARALAPGGLMVVQAGSPYSTPTAFWRIISTIRSAGYAVTPYHVHVPTFGDWGFALARLTDIAPTPAVPSTAPALRFLDQQVLEAATVFSGDIRPRTLDPSTLDNPHIVEDMRHGWD
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSKDFVHLHLHTQFSLLDGAIKIDELVKKAKEYGYKAVGMSDHGNLFGSYKFYKALKAEGIKPIIGMEAYFTTGSRFDRKTKTSEDNITDKYNHHLILIAKDDKGLKNLMKLSTLAYKEGFYYKPRIDYELLEKYGEGLIALTACLKGVPTYYASINEVKKAEEWVKKFKDIFGDDLYLELQANNIPEQEVANRNLIEIAKKYDVKLIATQDAHYLNPEDRYAHTVLMALQMKKTIHELSSGNFKCSNEDLHFAPPEYMWKKFEGKFEGWEKALLNTLEVMEKTADSFEIFENSTYLLPKYDVPPDKTLEEYLRELAYKGLRQRIERGQAKDTKEYWERLEYELEVINKMGFAGYFLIVQDFINWAKKNDIPVGPGRGSAGGSLVAYAIGITDVDPIKHGFLFERFLNPERVSMPDIDVDFCQDNREKVIEYVRNKYGHDNVAQIITYNVMKAKQTLRDVARAMGLPYSTADKLAKLIPQGDVQGTWLSLEEMYKTPVEELLQKYGEHRTDIEDNVKKFRQICEESPEIKQLVETALKLEGLTRHTSLHAAGVVIAPKPLSELVPLYYDKEGEVATQYDMVQLEELGLLKMDFLGLKTLTELKLMKELIKERHGVDINFLELPLDDPKVYKLLQEGKTTGVFQLESRGMKELLKKLKPDSFDDIVAVLALYRPGPLKSGLVDTYIKRKHGKEPVEYPFPELEPVLKETYGVIVYQEQVMKMSQILSGFTPGEADTLRKAIGKKKADLMAQMKDKFIQGAVERGYPEEKIRKLWEDIEKFASYSFNKSHSVAYGYISYWTAYVKAHYPAEFFAVKLTTEKNDNKFLNLIKDAKLFGFEILPPDINKSDVGFTIEGENRIRFGLARIKGVGEETAKIIVEARKKYKQFKGLADFINKTKNRKINKKVVEALVKAGAFDFTKKKRKELLAKVANSEKALMATQNSLFGAPKEEVEELDPLKLEKEVLGFYISGHPLDNYEKLLKNRYTPIEDLEEWDKESEAVLTGVITELKVKKTKNGDYMAVFNLVDKTGLIECVVFPGVYEEAKELIEEDRVVVVKGFLDEDLETENVKFVVKEVFSPEEFAKEMRNTLYIFLKREQALNGVAEKLKGIIENNRTEDGYNLVLTVDLGDYFVDLALPQDMKLKADRKVVEEIEKLGVKVII
The following text describes a protein:
Function:
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway. Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
Subcellular Localization:
Virion. Host nucleus.
Sequence:
MASQGTKRSYEQMETGGERQDATEIRASVGRMIGGIGRFYIQMCTELKLSDYEGRLIQNSITIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYRRIDGKWMRELTLYDKEEIRRVWRQANNGEDATAGLTHIMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTIAMELIRMIKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLAVASGHDFEREGYSLVGIDPFKLLQNSQVFSLIRPNENPAHKSQLVWMACHSAAFEDLRVSGFIRGKKVVPRGKLSTRGVQIASNENVEAMDSSTLELRSRYWAIRTRSGGNTNQQKASAGQISVQPTFSVQRNLPFERATVMAAFIGNNEGRTSDMRTEIIRMMESAKPEDLSFQGRGVFELSDEKATNPIVPSFDMNNEGSYFFGDNAEEYDN
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSDEKDKDGLINPRVNRENYKRRQELEEARKLGAIPALVDEEGRDINPHIPQYITNVPFFYGNTGPTLKHQRQQDDRVPQHDDIHRQVKRGVKKGSGSTRYKKGACENCGSTTHKKQDCVERPRRVGARFNNKNIAADEYIPTELNHSFEGKRDRWQDYDPAEHLEVVREFEKIEAEKRKLKLQELKQRAAEARERAAAGEEDVSAEKRVDPKAEEASDDSDDDDDDDKDKADDLRYAESANMAGAKIDTKNRISVRNLRIREDTAKYLLNLDVNSAHYDPKTRAMRADPLRGTNKKATKAFAGENFVRHTGEVPHIADRQLFAWDAADKGVYRALVLIPAGPRCSHGKHCALILLLLVVVVSPLRLSSCPLLVSRFENAHRLSIAYIDQGASHSRPPLLGVMAGVDVHLQADPTKAEMLHKAFEQKKQQFGEQQRQSILEKYGGAEHLKAPPKELLMAQTEHYVEYSQSGRVIKGNEKAKVQSKYEEDVYPGNHTSVWGSYWSRGRWGYACCHATEKQSYCTGAEGRAARAADPTQLLKLRGQAAEQAQGEGEEAADGKPVETLLEQHRKSNKGKRSKDEAAAEDDDDEAREKRIKEYMEKHRKQEREADRLMSMDERSRPFNSMKESEHKMSEEEMEAYHRTRVHADDPMAAFMK