lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor. Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling. Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits. Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes.
Subcellular Localization:
Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, stereocilium. Cytoplasm. Membrane, clathrin-coated pit.
Sequence:
MQPPPRKVKVTQELKNTQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGIQKLASQYLKRDWPGIKADDRIDYRSMYPVWKSFLEGTMQVAQSRINICENYKNFISEPARTVRSIKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLETSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSRQLESETGTTEVLDDLECHGVAVSEQSRAELEQKIDEARENIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENERWARLPAVTNNDTLHSLNADPEREEGEEFEDNMDVFDDSSSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFSGRIGVFPSVLVEELSASENGDTPWMREIQISPSSKPPGSLPPLPLYDQPPSSPYPSPDKRSSQYFPRSPSANENSFLAESPGFSQAPRHTPETSYGKLRPVRAAPPPPTQNHRRPAEKIEDVEITLV
The following text describes a protein:
Function:
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway; The FZ domain is involved in binding with Wnt ligands.
Sequence:
MRHNRLKVLILGLVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACDGLLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLGAPDRTGANQALIKQRPPIPHPYAGSGMGMPVGSAAGSLLATPYTQAGGASVASTSHHHLHHHVLKQPAASHV
The following text describes a protein:
Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MSLTMVTLRWSCFHRCPCPSSIFAAMNRQAAQLSYHYKSFCGDYERVETALERLEASGYYWSTLSGTEAKNLLSDQPVGSFLIRDSSDHHHLFTLSLRTSAGITNLRIKLEGPSFYLETVAGAETPHTFPCVVKLVEHYMRLTATGESDSNLCYIEGNDQPVPLMLTQPMNCKVVSLQYLCKRTVVANMPSEASSSGENMEELPVSKMLRNAFRN
The following text describes a protein:
Function:
Odorant receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKISNNSLGFLPTTFILVGIPGLESEHLWISVPFSLIYIIIFLGNGIILHVIRTDIALHQPMYLFLAMLALAEVRVSASTLPTVLGIFLFGNTEISLEACLFPDVLHPFFIHDGASCAAGHVFGPLYSHLQPTELHSYPDTAQGLWHRSYYRTEKHYAHGSVAHSLMASALLWPQCPLTFLLSAPQSYLSCGNISVNNIYGIFIVTSTFGLDSLLIVISYGLILHTVLGIATGEGRKKALNTCGSHVCAVLAYYVPMIGLSIVHRLGHRVSPLLQAMMANAYLFFPPVVNPIVYSIKTKEIHGAIVRMLLEKRRRV
The following text describes a protein:
Function:
[GLV10p]: Signaling peptide (root growth factor) that maintains the postembryonic root stem cell niche. Regulates the pattern of root growth and lateral root development by modulating the length and the number of cortical cells in the root apical meristem (RAM), and the anticlinal asymmetric cell divisions in lateral root initiation cells.
Miscellaneous:
MISCELLANEOUS: 'Golven' means irregular waves in Dutch.
Subcellular Localization:
[GLV10p]: Secreted; Endoplasmic reticulum. Note=The precursor is detected in the endoplasmic reticulum probably during its processing.
Sequence:
MSSIHVASMILLLFLFLHHSDSRHLDNVHITASRFSLVKDQNVVSSSTSKEPVKVSRFVPGPLKHHHRRPPLLFADYPKPSTRPPRHN
The following text describes a protein:
Function:
Part of a type III secretion system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAQQVNEWLIALAVAFIRPLSLSLLLPLLKSGSLGAALLRNGVLMSLTFPILPIIYQQKIMMHIGKDYSWLGLVTGEVIIGFSIGFCAAVPFWAVDMAGFLLDTLRGATMGTIFNSTIEAETSLFGLLFSQFLCVIFFISGGMEFILNILYESYQYLPPGRTLLFDQQFLKYIQAEWRTLYQLCISFSLPAIICMVLADLALGLLNRSAQQLNVFFFSMPLKSILVLLTLLISFPYALHHYLVESDKFYIYLKDWFPSV
The following text describes a protein:
Function:
Component of a heterodimeric G-protein coupled receptor for GABA, formed by gbb-1 and gbb-2 (By similarity). Within the heterodimeric GABA receptor, only gbb-1 seems to bind agonists, while gbb-2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (By similarity). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (By similarity). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (By similarity). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (By similarity). Along with gbb-2, may couple to the G(o)-alpha G-protein goa-1 to negatively regulate cholinergic receptor activity in the presence of high levels of acetylcholine in ventral cord motor neurons. As acetylcholine depolarizes body wall muscles, modulation of acetylcholine levels most likely results in the control of locomotory behavior. Acts in neurons to regulate lifespan, and this may be through G-protein-egl-8/PLC-beta signaling to the transcription factor daf-16/FOXO.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Alpha-helical parts of the C-terminal intracellular region may mediate heterodimeric interaction with gbb-2.
Sequence:
MFVRSSWLLLWGTIVWASAEPVTLHIGGTFPMESGSGGWAGGEACLPAVEMALKDVNSRLDILPGYVLNMTNHNSQCQPGLAMQQLYDFLYKPPTKLMLLTGCSPVTTVIAEAAPVWKLVVLSYGGSSPALSNRNRFPTLFRTHPSANMQNPTRIHIMEKFKWKRFTILMSVEEVFVTTAKDLEAIARKKGIKVDRQSFYGDPTDAMKTLQRQDARIIVGLFYVTEARKVLCQAYHHGLYGRRYVWFFIGWYADTWYIPPPEEHLNCTAEQMTEAAEYHFTTESVMLSRDNIPAISEMTGMQFQQRLTQYFQKDTANVGGFPEAPLAYDAVWALALAFNCTRNNLPSHIRLENFTYDNKVIADTLFQCVKNTSFRGVSGKVMFSDSGDRIARTQIEQMQGGKYKIMGYYDTTSGDLEWYNKEQWLNGKGPPPDSTVIKKHAMTVSNEFYYPTILFAVLGIAACVFIYLFTQKHHERLIIFQSQPECNNILLIGCSLCLFSLFLIGLPSDDISISESLFPLLCHARVTILLFGFTFAYGSMFAKVWIVHRMGATENQQLASRQKDEEENTPWEGIRTLISTMVGRQALMRKSSGQAYGALLEKRNTVLNQPISSSKFYVIVAALTAVDVFVCFVWVLIDPLHLTEQKFPLFTPADSEEDEMIMPVLQQCQSNQQEVWIGIIMGFKCLLLVFGTFLSYETRNLKLRFINDSRFVGLAIYNVAVMTLVTAPVVTLLIHGKVDANFAFISLTVLICTYISVGLIYGPKIRHIIKVPPSADEIQLNGNVGPGVMSKVDQKRYDMLKKENETLQIQIEEKERKIHECKERLEELTKNSETEDMNAQLLCENDKQIADENLTYSTATTLTTTIPLIDLQNGNHPGQIYENDNDDDGSSTSSDEILL
The following text describes a protein:
Function:
Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions. TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation. At the 8-cell stage, during morula development, controls expression of cell-polarity genes. Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2. Binds to both closed and open chromatin with other transcription factors.
Subcellular Localization:
Nucleus.
Domain:
The PPxY motif mediates interaction with WWOX.
Sequence:
MLWKITDNVKYEEDCEDRHDSSSNGNPRIPHLSSPGQHLYSPAPPLSHTGVAEYQPPPYFPPPYQQLAYSQSADHYSHLGEAYAAAMNPLHQPAATGSQQQAWPGRQSQEGSSLASHHSRSASLIPHISGLEGGSVSARREVYRRSDLLLPHAHALEAGLAENLGLHEMAHPIEEVQNVDDAHLLLHDQTVIRKGPISMTKNPLGLPCQKDLVGVVMNPSEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAAHVTLLTSLVEGEAVHLARDFAYVCEAEFPSKAVADYLTRPHLGGRNEMATRKSMLLAAQQVCKEFTDLLHQDRTPNGNNRPAQVLEPNIQNCLSHFSLITHGFGSQAICAAVSAVQNYIKEALIAIDKSYMNPGDQSPADSSKTMEKMEKHRK
The following text describes a protein:
Function:
N-acetylglucosaminyltransferase involved in the Golgi-specific modification of N-linked glycans.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein. Vacuole membrane; Single-pass type II membrane protein.
Sequence:
MGNKKATLLPYRRDSASSEADFFDIPDEPCLAIAKRQLRRIRTWIFFAVFIILILWFRREAPSPAPVSHIDYNKVDWSRYAYSQYATSSAYLCNAVMVFEALERLGSRADRVLFYPEDWDLFVADDHDRDSQLLVLAKEKYKALLVPISAEMIKAGGGSGESWDKSIAKLLAFGETEYDRVIHIDSDVTVLQSMDELFFLPPAKVAMPRAYWALPDTKTLSSLLIVIEPSYREFKALMESAQPALHGQVEVDSNETQRYDMELLNNRYADSALVLPHRQYGLVTGEFRKKDHRSFFGNDYETWDPDKVLAEAKLVHFSDWPLPKPWVLSNQKLLAEILPKCDFKPGTMQERGCRDREVWKSLYEDFRRRRKVCPKIRTIHTEYG
The following text describes a protein:
Function:
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MASTAFQIIAFVLTFLGLMLLHAATVSNYWKYSTSAKNIITSSWISEGLWRSCVATSFGSVQCKTFSSLLSLETYLQVCRALMIISLISGMCGILLSLLGMKCTQLGSTSENTKIKISITGGVIFILGGLSSMIAVSWYAAQVTTQFFDSLYGGIKYELGTALFVGWAGSLLSILGGIFLTCSGCKEKHRSQKYDYAVAQRTNKSRIYIKKSEKVVPVQDYV
The following text describes a protein:
Function:
Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MKEIYRLVDVSYKYPNGSIALDNVNLNIYKNEVVAILGPNGAGKTTLLKILDGLVFPDKGEVYFEGKKLTDEILRDKELMKEFRRKVGFVFQNPDVMLFNPTVWDEVAFSPLHLYSKEKAIEVTDKTLKDMKIYHLKDRHPYNLSGGEKKKVSISCILSVEPEVILMDEPTSALDPKSRAEIMNLIKSFKECGKTVVLVTHDLNLACLADRCYVLNKKVIFEGKVKDLFSLNLDELNLDVPEISKLFIKLKNMGYNINEIPVTLDEAVNIISKLFQKY
The following text describes a protein:
Function:
Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence. Involved in megakaryocyte differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MGEKKPEPLDFVKDFQEYLTQQTHHVNMISGSVSGDKEAEALQGAGTDGDQNGLDHPSVEVSLDENSGMLVDGFERTFDGKLKCRYCNYASKGTARLIEHIRIHTGEKPHRCHLCPFASAYERHLEAHMRSHTGEKPYKCELCSFRCSDRSNLSHHRRRKHKMVPIKGTRSSLSSKKMWGVLQKKTSNLGYSRRALINLSPPSMVVQKPDYLNDFTHEIPNIQTDTYESMGKTTQTSGLPRDPQELMVDNPLNQLSTLAGQLSSLPPENQNPASPDVVPCSDEKPFMIQQPTTPAVISAVSTSMPQSSSPTSPEPRPSHSQRNYSPVAGPSSERSAHTSTPSISNSQPSTPTPVLPVQDPQLLHHCQHCDMYFADNILYTIHMGCHGFENPFQCNICGCKCKNKYDFACHFARGQHNQH
The following text describes a protein:
Function:
May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MATSKAKVMAKATAPSRIHQYTPITATTPIIPQQIPVNNNPDLRPFFSRMTATLRESFAQRRPWFEIIDRSNFSRPETFSEAVSRVRKNLSYFRVNYSAILAVFVALSLLSHPISLFFFVGVVWAWLYLYLFRSPDQPVVLFEHNFSDRQALGILILSTILIVFLTGLGSLIMYSSLIGLGMLCIHGAFRIPQEVFVEDQQPDIAAGFLSFLTVTAAAAVAAAPPMPRAQPMPRV
The following text describes a protein:
Function:
Plays an important role in the physiology of adrenergic neurons.
Subcellular Localization:
Cytoplasm, perinuclear region. Cell projection, axon. Note=Expressed in dopaminergic axons and axon terminals.
Sequence:
MMAVAAAQKNREMFAIKKSYSIENGYPSRRRSLVDDARFETLVVKQTKQTVLEEARSKANDDSLEDCIVQAQEHIPSEQDVELQDEHANLENLPLEEYVPVEEDVEFESVEQEQSESQSQEPEGNQQPTKNDYGLTEDEILLANAASESSDAEAAMQSAALVVRLKEGISSLGRILKAIETFHGTVQHVESRQSRVEGVDHDVLIKLDMTRGNLLQLIRSLRQSGSFSSMNLMADNNLNVKAPWFPKHASELDNCNHLMTKYEPDLDMNHPGFADKVYRQRRKEIAEIAFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKHACAEYRAAFQKLQDEQIFVETRLPQLQEMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQSTQYVRHVNSPYHTPEPDSIHELLGHMPLLADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGLCKEHGQIKAYGAGLLSSYGELLHAISDKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDAKDKFRRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLVHQMNTEILHLTNAISKLRRPF
The following text describes a protein:
Function:
Part of the ABC transporter complex CntABCDF (Opp1) involved in the uptake of metal in complex with the metallophore staphylopine (StP). Involved in the import of divalent metals ions such as nickel, cobalt and zinc. Probably responsible for energy coupling to the transport system. Plays a major role in nickel/cobalt import in zinc-depleted conditions. Contributes to virulence. Required for full urease activity in vitro.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MTLLTVKHLTITDTWTDQPLVSDVNFTLTKGETLGVIGESGSGKSITCKSIIGLNPERLGVTGEIIFDGTSMLSLSESQLKKYRGKDIAMVMQQGSRAFDPSTTVGKQMFETMKVHTSMSTQEIEKTLIEYMDYLSLKDPKRILKSYPYMLSGGMLQRLMIALALALKPKLIIADEPTTALDTITQYDVLEAFIDIKKHFDCAMIFISHDLTVINKIADRVVVMKNGQLIEQGTRESVLHHPEHVYTKYLLSTKKKINDHFKHVMRGDVHD
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MLGIRKNIRISVNFLQRRTITVKQKLGKNRPLPGWDPNSEYFRPGPTMLNRLQEHLHDTILPDVLAASYRHDIDTALSTDEHTQKDRLPRWIGDNPYYKNRPPQKMRGNKPLLPVKESVNPKNLPSISKVVVSTMHKEALVDKTQLLSTMMAFRSITGLQPEIVYARKDVSPWKLRSGVPVGVKVTLTGESMYTFLSILSELVLPQLHDFKGLSPTSGDQTGNISFGLPSEVMPLFPQIEAVYEMYPHSLPGFNVNITTNSKDTRLARFFVSSLIPFTDGNKEGYVG
The following text describes a protein:
Function:
Functions probably in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with other importin subunits (Probable). Involved in the regulation of the abscisic acid (ABA)-mediated pathway in response to cold or salt stress. Involved in UV-B responses by regulating accumulation of UV-absorbing pigments through mediation of MYB4 nuclear transport. Involved in trichome initiation by controlling GL1, GL2, GL3 and TTG1 transcription and may affect an upstream regulator of GL3 and disrupt complex function. Acts as a negative regulator miRNA activity by regulating miRNA loading into AGO1 complexes.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDLHSLALILRTAALSPIPDERKVSEQQLNQLEHTPQHLVRLLQIAVDGNCDMAVRQIASIQFKNLIAKNWSPEDCGPAVRQQQIFESDKELVRDNILVYVTQVPTLLRSQLGESLKTIIYADYPEQWPRLLDWVKYNLQNQQIYGALFVLRILSRKYEFKSDEERTPVSRIVEETFPQLLTIFNGLIQIPNPSLEIAELMKLICKIFWSSIYLELPRQLFDLNVFNAWMVLFLSVSERPVPVEGQPMDPELRKSWGWWKVKKWTVHILNRLYSRFGDPKLQSPENKPFAQMFQKNYAGRILEGHLNFLNTIRVGGYLPDRVINLLLQYLSNSISKNSMYKLLLPRLDVLLFEIVFPLMCFNDNDQKLWEEDPHEYVRKGYNIIEDLYSPRTASMDFVNELVRKRGKENLPKFVKFVVEIFLSYEKATVEEKPYRQKDGAMLAVGALCDKLKQTDPYKSQLELMLVQHIFPDFNSPVGHLRAKAAWVAGQYAHINFSDQNNFRKALHSVVSGLRDPDLPVRVDSVFALRSFVEACKDLNEIRPILPQLLDEFFKLMNEVENEDLVFTLETIVDKFGEEMAPFAFGLCQNLAAAFWRCLNTSEANDDSDDMGALAAVGCLRAISTILESVSSLPQLFVEIEPTILPIMQKMLTTDGQEVFEEVLEIASYMTFYSPSISLDIWSLWPLMVEALVDWGIDFFPNILVPMDNFISRGTAHFLTCKEPDYQQSLYNVLSTLMTDRNIEDSEIESAPKLIEVVFQNCKGQVDQWVEPYLRLTVDRLQRAETSYVKSLLIQVVANMLYYNPGLTLGVLHNTGLASKVFDLWFQMLQQKRKSGLPANFKREHDKKVCCLGLTSLLALPGGQFPDEALQRVFRATLDLLVAYKNQLAEAAKETEVDYEEEMNGLQSSDDDYDDDGSDGEMDDTEEGDEAQSVKLQKLAAQAKAFHYDDDDDDDSDDDFSDEDEFQSPIDEVDAFVFFVDAIRVMQASDAQRFQNLNQSLDFTYQAIANGIAQHAELRRVEIEKEKQKKLAAASTPVTAL
The following text describes a protein:
Function:
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (By similarity).
Subcellular Localization:
Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Sequence:
MEEFNTTVRISGFVLSSLMFHHLNSDADVEGLILGESVGEENCRITDSQIDHIQFEHTLNIQKHIPCHKLHSFYSNVGDVSEQKIRQILSDYKEENVIGWYRQRRNTRQQMTFMEQVIHRNMRKILSNQELVFMLLTPSQGTASGSTHRLEFSAFIWHSSQYINIPISVSNLGNLEQQDYWRVSSTCPSLGQSQAVNQHRAKFFCSGDDLREVRNVSDMNDALLAEMQKVCVEVEKSERTVEKLQEDIAQLKEAIGKQKTHPEEHETPISACPEEPKENTLLCSALRTLFPSVPSLRTQTLTVHGFPVLQLCCNTDHNIDISTKLPQILENQHSRRKVTAPRLRKKCLVASFPQRLKRKRKTREVSESASESGSDTEIEMNGQSGSNSPVF
The following text describes a protein:
Function:
Required for intron-independent turnover and processing of mitochondrial RNA. It is a key control element in nuclear-mitochondrial interactions.
Miscellaneous:
MISCELLANEOUS: Present with 1440 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MALVKYSTVFFPLRSLRLFVSIKKAYYHSEPHSIDLFHDKDWIVKRPKFLNLPKNEHSKLDIFQFNFNKSESNNVYLQDSSFKDNLDKAMQFIYNDKLSSLDAKQVPIKNLAWLKLRDYIYQQLKDPKLQAKTYVPSVSEIIHPSSPGNLISLLINCNKISNLVWKSVLKYSLSNNITTLDKFIHVLQQTFDHVYEQEILPMMTNTDDTDGAHNVDITNPAEWFPEARKIRRHIIMHIGPTNSGKTYRALQKLKSVDRGYYAGPLRLLAREVYDRFHAEKIRCNLLTGEEVIRDLDDRGNSAGLTSGTVEMVPINQKFDVVVLDEIQMMSDGDRGWAWTNALLGVVSKEVHLCGEKSVLPLVKSIVKMTGDKLTINEYERLGKLSVEEKPIKDGIKGLRKGDCVVAFSKKKILDLKLKIEKDTNLKVAVIYGSLPPETRVQQAALFNNGEYDIMVASDAIGMGLNLSIDRVVFTTNMKYNGEELMEMTSSQIKQIGGRAGRFKSRSASGGVPQGFITSFESKVLKSVRKAIEAPVEYLKTAVTWPTDEICAQLMTQFPPGTPTSVLLQTISDELEKSSDNLFTLSDLKSKLKVIGLFEHMEDIPFFDKLKLSNAPVKDMPMVTKAFTKFCETIAKRHTRGLLSYRLPFNLLDYNCIPNESYSLEVYESLYNIITLYFWLSNRYPNYFIDMESAKDLKYFCEMIIFEKLDRLKKNPYAHKPFGSTRGHLSSSRRRLRT
The following text describes a protein:
Function:
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
Sequence:
MNELGFPVFSADVLSKITVKAVPVVAPTDPHNETAIYRSVLSPNELLVTIPNMRTMHEVFEESVKRHPNLPALGTRYASVHPSTGAVTWGPYVFETYAQVAKKRDHLAYGIQHIYTNVIKESAEKWNLGIFSSNRAEWVIADLAAQAFSVAVVALYDTLGADTSEYILNHADVSVVVASIDKVPLLLSLAHKTKLKAIIALDSIPSVSTLGSVTNPFQFAKIWAKEKGIELYSFNEVMDLGIKHPIPFRLPSEEDVFCLCYTSGTTGNPKGAVLSHKNMIAVLRGNFTQFSIDATDVHISYLPLAHIFERCVVSTMLAGAGSIGFYRGDVTLLMEDIGVLHPTIFPSVPRLLNRIYDRITDQALHSGSALKTALFQRALDAKLENIRNDKVLTHFFWDSVVFSKLKALLGGRVRLIVSASAPINGDVLEFLRVAFSCQVLEAYGQTECTGLFTTTWPNDFSKDNVGPVAVTSELKLVSVPEMNYHAKDLKGEIWIRGPSVFKGYHKDVAKTKEALTDDGWLLTGDIGMLDSKGRLSIVDRKKNIFKLSQGEYIAPEKLESTFLKSSFVAQIYVHGDSLQNELVAIVVPNPETAVKWGISNGVLPTDTSTDVARQPGQPSHPATIQVCKSLALRNVILEDLIAVGKLDKLRGFEFVRAIYIEPDMFSAESGLLTPTFKLKRNEAAIKYRPELDQLYQERATATKSTQAKL
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MVRAVKKKVAGMQAAGPVVGNVLEQFREALQITWRAYSRDLKSDQRLLLIDTLCGGLVTIGLVQVLFIAVIRDTFPFNAFLAGFISCVGQFVLLISLRLQLREQFAGISSQRAFGEFVLASLVLHFICLHFIN
The following text describes a protein:
Function:
Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis.
Subcellular Localization:
Nucleus.
Sequence:
MSTGSSPFVDHKSNNSTISINNNSSILNESSISKAYVSKLEFQLDTIKTENRILQQEKDQITSDYRKIIDEKNQELENLKLNFKYVYDEKNQLESKLTNQEQVSTNNINQLSDEIQTYKRENLKLTKDYNSLLDKFNKLNRKNQQIMHDLNKEIEVNDKLHQELKIKEKTNQELQKASDTAINELEQYSKILDKKNGSDNLLYKNLTTKSNNLQNINHQLQNKIDQLLQNKTSNELLKQQNQSLLHKLQNLENIESKYLQLEIEKLQLETKYNDLFKALDTAIASSNEYKDNENTDDTIHTSKVKSFIEYCNNLQAKNLTLQEKYDSKIIQVKELTKELEDHAREIETDFLPTITDLESKLKVYADQNTKLERTKSLREKEITFLRNSLKQMEQIHANQQHKQQEQEKEENTENKSISQYMTNLEKLVDEYKTKIDELEKKNLEYNKSSIITNEKTPSNKRQRLESNYTFKTQAIELEKENIEISSKLKQAESTIEQLKFKISELDKVETRKEQYRILQLKNNLISQDQFIKQTTLIALRKENEELINKYIKNLPIEEQIPKGVFQRQEDDKQRLQAQIDHLTKRSTRLREVFTKKSKDIITVIAKYFGFIIEFLPNPINPTDLFSRIKLRSRYIPSEEDCYLIIDVENRGLKAHGNFQFKQICEELAQYWVNENNQFPCLLSAVNLKLYEIYASK
The following text describes a protein:
Function:
Specifically required in males for proper segregation of autosomal bivalents at meiosis I. Expression is required in the male germ line prior to spermatocyte stage S4. May have a role as a bridging molecule maintaining adhesion to hold autosome bivalents together via heterochromatic connections (By similarity).
Miscellaneous:
MISCELLANEOUS: Drosophilid specific gene duplication generates rgr and tef. Teflon has a function unique to Drosophilids.
Subcellular Localization:
Nucleus. Chromosome. Note=Male meiotic chromosomes.
Sequence:
MSSFLDILGDGHVNFEKCGDVVVSPKDNMVAMFCHFCKDIFTHLPEFMRHLQWSHSDVLQFTKEQNVYRVEELMSLETSEDDVQSQANSCSSGDSGLAGEMEDADGEPGSSECLANNLEIMNALAAFDVDVDGLNNVSHEQSYSKTPPDSRTEGFRCARKPGRVEKPPSICDLKSYNITRHSRKREAIKQRLSSVKKRIMRSLENDVISPRLNKLRSKLNNSLSSNISGPPKQSKMPSLLENSSVNELPAVLESTNPPNFDSEQPYVVSTTIKPSIRPCPSRTAVKTDRNISHQPVARRSTVNIERVDILPPINIKQKMKMSAKDIPFWESIIISSVASQQPSELNTTNNAVDQPPKRPERRSSLTVISSSPIQAMKPMRRSSMTRENTSPESSGILRSGEVESPAKANKRTKDSFEETSSSNEKGNAKRSKLEQNRCSMNFSLSASVTEYIRSDLKTSKLDLDSILRLAEPLESDYFKNTIVEDQVKNATKMGSPQKEFTKLQIGVKPEMEALKEDLRLLKTVGLLVLKDSCFEDKLPFEQSESFRKTAAKFSKIYHTYDTIWSYRKTKTIGVHQRLTEQLNSFTEEVNREIDCHLTTNEIKRILNLINSWYAYQIDQRFFRKATLSYSVEHYMFLFHFLPKINPTVYFCECCEEIFPNEARYKKHVQSVHAVHAFTCSECGKSFKRLYFYEKHLKTVHLKP