lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist. Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation. Inhibits pre-mRNA splicing. Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1.
Subcellular Localization:
Nucleus, nucleoplasm. Nucleus speckle. Nucleus envelope. Note=Colocalizes with BMLF1 in the nucleus. Localized in the nucleoplasm with a granular staining pattern and excluded from the nucleoli.
Sequence:
MKRQSERDSSPSGRGSSSSAKRPREREREAEAGGRRAAHKASGGTKHPVPARARDKPRGSGGGGGHRDGRAAGDANHRASGGRSSGAPGGGGRTGKASGDPGAGGASPRASPLPPPPPPPGAEPAGPGSTAAPEYKTLLISSLSPALPAEHLEDRLFHQFKRFGEISLRLSHTPELGRVAYVNFRHPQDAREARQHALARQLLLYDRPLKVEPVYLRGGGSSRRSSSSSAAASTPPPGPPAPADPLGYLPLHGGYQYKQRSLSPVAAPPLREPRARHAAAAFALDAAAAAAVGLSRERALDYYGLYDDRGRPYGYQAVCEEDLMPEDDQRATRNLFIGNLDHSVSEVELRRAFEKYGIIEEVVIKRPARGQGGAYAFLKFQNLDMAHRAKVAMSGRVIGRNPIKIGYGKANPTTRLWVGGLGPNTSLAALAREFDRFGSIRTIDHVKGDSFAYIQYESLDAAQAACAKMRGFPLGGPDRRLRVDFAKAEETRYPQQYQPSPLPVHYELLTDGYTRHRNLDADLRVRDRTPPHLLYSDRDRTFLEGDWTSLSKSSDRRNSLEGYSRSVRSRSGERWGGDGDRSIAKPWEERRKRRSLSSDRGRTTHSPYEERSRTKGGGQQSERGSDRTPERSRKENHSSEGTKESGSNSLSNSRHGAEERSHHHHHHEAPDSSHGKKTRESERNHRTTEAEPKTLEEPKHETKKLKTLSEYAQTLQLGWNGLLVLKNSCFPTSMHILEGDQGVISGLLKDHPSGSKLTQLKIAQRLRLDQPKLDEVTRRIKQGSPNGYAVLLAIQSTPSGPGAEGMPVVEPGLQRRLLRNLVSYLKQKQAAGVISLPVGGSKGRDNTGMLYAFPPCDFSQQYLQSALRTLGKLEEEHMVIVIVRDTA
The following text describes a protein:
Function:
Together CLIP-190 and jar may coordinate the interaction between the actin and microtubule cytoskeleton. May link endocytic vesicles to microtubules. May play a role in formation of furrows during cellularization.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, perinuclear region. Note=Microtubule-associated. Lva-CLIP-190 complexes are found at the Golgi. In the fat body, localizes to a perinuclear non-centrosomal microtubule-organizing centers (ncMTOCs).
Sequence:
MSDDTSASGGTSAPFPSPVTADPEPGATASKLPGPIRSNIPTPATSGTGIPQPSKMKAPSSFGSTGSVSKIGRPCCNHTTPKSGPPPREATSMSRESDDNLSSINSAYTDNSSAVLTANTEQFIIGQRVWLGGTRPGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSRLTRLTTYPLAGAQTPTSPLAKSSPDRSRTVSPTASIRSSMLRSPGIGGKNGMAVGDRVIVSSGFGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKVSLSPSSKKTRLSRTGSRESLTSIGTMNSIATTATSRMRMNAQQRKSSTPVKPILATPKSQFSMQDLLREKQQHVEKLMVERDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIHDLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLAKINFLNSIIADMQQKNDALKAKVQTLETLPMDFTKPHAFDALTKRKPAPRLFCDICDEFDQHDTEDCPIQGSEDQDYSTPSSESNNNEKERKLPAPRKYCDSCEVFGHDTSECADDETY
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the degradation of the iron exporter ferroportin/SLC40A1 and thus regulates iron homeostasis.
Subcellular Localization:
Cytoplasm. Membrane; Single-pass membrane protein.
Sequence:
MEDDSPVARACTMPRFISGYDDARKKLSRNLPTETSFRDVKVKRQVRSSSVRVSRSSSRLCLDEDDGDPEERSRREVKDTEGNNNNNCNGVGRARRRASAVEIPRRNLGDFKQRPALLGAHSRMQRDAEQGSAKTDITAESGAENEECKNSDGETRQPGSKNEQTSSDLTSIVRRVESVTAECQHACDSGSNAVTSSGEPFKAKEHVYCTVYCIENDRHQARAESTDRRGDATQIDLETGQVASPSPEPELYSLDDLVDPFEDISQWLYREQVEAGTLMQNCRVCLEEKSIASLPCCGKAVCDACLKLYVSSQVRLGKHLISCPIPECSGTLEEKLVLSHLTTEDVAKYQYFLELSQLDSSTKPCPQCSKFTSLKTHNPNRSESKFKIQCSNCQFVWCFKCHAPWHDGIKCRDYRKGDKLLRSWASVIEHGQRNAQKCPRCKIHIQRTEGCDHMTCAQCNTNFCYRCGERYRHLRFFGNHASNLSVFGCKYRYLPDKPHLRRLIRGSVCATKVLIAPVVILLVIVVGALALVIGLVAFPVYYVCKRKKKQRTRGSVRWI
The following text describes a protein:
Function:
RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches.
Sequence:
MNNTVNSRNSLSSQSLQAAAQAAAQINAQLAAEGKIQPQQNLQASNNGAQKKDKKLKTGRKDLFNAEVEINNLPPRVRNLLTKGYIQEQIQWKSKAALCTKGRYVSQREKLTANDERPLYICIQAVDKHAVDEAIHHIQDFIAEHTGSSPTPPVISPTLVPNHPPPQVTLIRDKVYINLDHAPETFKIVERVLGPSGDNVNYIQTETGVSVSLQGQGISSSNASDEPHHLLLEHIEPSAVQNARSLALSLVGTLQQDFIQWQREQQALQQQQLVYTFSQPYYSGSSTASGNFTYPAVAMVYGMDNGLTQTAAVREPQSVQSHQHTRGLPGKRPSRFDYQQSTGVFPVRETARTSFHPHRMTADFLDIQRT
The following text describes a protein:
Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.
Sequence:
MAHGIDYRDKLILAPMVRVGTLPFRMLAAGYGADLTYGEEIVDHKMLKCSRVVNDVLGSIDFVENGTNDVVFRTCKAERDHVVFQMGTSDPYRALTVAQLLCRDIAAVDINMGCPKPFSVTGGMGSALLSQPELVSEILTTLRRNLDIPVTCKIRLLKSTQETVELARRIEKTGVSAIAVHGRRIPDRPKDRAKWDGIADVVSALSIPVIANGDVFEPPDIPRIKAATGASSVMVARGALWNASIFRPEGKLDWEECIVWENDIKFTKYTVNNMIIRNSSLESPEGRAVHKCQSLLHLA
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MSNSEVPTGFIILEFHQNCALYGSQSDSFESVERIQARELKKLDWLRLKDQRFCKKDRQLDILVEKKLLEKFSTYFRALNSFREADCERIIVDWDVALFCILLEMFHSGHLDILASKVAALLETSVFFGVDEAIIRINAWMTLTFSSKDPREILSVLKSLPVIWDASHRFGHSSLLNFCVEFLAVNFMEARSMSSFNDIPHGLLSACVDHIQLTVHSEKDLFDSLRCWCEGQDWVDEAEEIISERKTSIMNKIRTSLVPLSVLLAYYPSKNCLDCNNRTIRITNYLEYLDLSGCHEVDDDMLFQSSSSAPLPAHCPSVPPGDIPQMLMQMQIIESPFPAFRYTEPVRNSKWPVIPKFENLKILNLSYCNKISEDALLLWLREACPQLTEFYAKNCPQIGFTFLPHLAKECPNLETVDISLDIFNLEDRNVHRILTEDENECRLIRRNYLLWGVSPMFLLSSLSVRGRSEVRDSVFNIIAANFRGVDLDVSNCRMLTDNGFSEGLKRLPQGLRSLKAQRTCFGPEACKVLSSPPVTGGVRNDLTILDLESCHGLTPEAIASILKTETTLSTLNLGDTTLDDIGLYLFKGHRLRKLCVRDTKVSAKALNFVLRNNPGLVSLDVKGCKSACIDEYEILLSGVDDIESQKSPNSISSIFRELESLHLLEDFEVGWRFSQLALEAMKPSTKRVRRLVVGVGGGICNMGLQKLSNYWPSLERLSLSFQIIDDDGIIQIVDRLRSLQILEIQNTISHVTPKGVAALVNRCPPKLVRLKLDRVVTGITDGDLLQLSKKCKKLASFSLVGCTQLTASSLVAISQNMRALTELKLEECDGLTSSGAQCLLDSCKALECLTLRHNGKGLEDSFVMKAKDELPYLWFLSLDMCDSLSSSFETPEMARRESPLNTALLSRCSSPETGVFPTASTSRNGRPQKRIPRDTIVLRWTRDLTLAYSTKTRI
The following text describes a protein:
Function:
DNA-binding adapter subunit of the SEU-LUG transcriptional corepressor of the C class floral homeotic gene AGAMOUS during the early stages of floral meristem development. Is part of the A class cadastral complex that define the boundaries between the A and C class homeotic genes expression and function. Interacts together with APETALA2 and LEUNIG to repress AGAMOUS expression. In association with LUG, regulates petal shape through AGAMOUS-independent mechanisms. Controls cell division during petal development and enable the proper patterning of petal blade vasculature. Required for the proper elaboration of petal polarity along the adaxial/abaxial axis. May act through direct or indirect regulation of PHABULOSA and YAB1 and thus regulate cellular proliferation within the developing petal blade. In association with AINTEGUMENTA (ANT), coordinates patterning cues and cellular proliferation along the three positional axes of the developing gynoecium. Required for the development of the medial ridge and subsequent ovule initiation.
Subcellular Localization:
Nucleus, nucleoplasm. Note=Does not localize in the nucleolus.
Domain:
Contains a dimerization domain which shares similarity with the LIM-binding domain of animal transcription coregulators.
Sequence:
MVPSEPPNPVGGGENVPPSILGGQGGAPLPSQPAFPSLVSPRTQFGNNMSMSMLGNAPNISSLLNNQSFVNGIPGSMISMDTSGAESDPMSNVGFSGLSSFNASSMVSPRSSGQVQGQQFSNVSANQLLAEQQRNKKMETQSFQHGQQQSMQQQFSTVRGGGLAGVGPVKMEPGQVSNDQQHGQVQQQQQKMLRNLGSVKLEPQQIQAMRNLAQVKMEPQHSEQSLFLQQQQRQQQQQQQQQFLQMPGQSPQAQMNIFQQQRLMQLQQQQLLKSMPQQRPQLPQQFQQQNLPLRPPLKPVYEPGMGAQRLTQYMYRQQHRPEDNNIEFWRKFVAEYFAPNAKKRWCVSMYGSGRQTTGVFPQDVWHCEICNRKPGRGFEATAEVLPRLFKIKYESGTLEELLYVDMPRESQNSSGQIVLEYAKATQESVFEHLRVVRDGQLRIVFSPDLKIFSWEFCARRHEELIPRRLLIPQVSQLGSAAQKYQQAAQNATTDSALPELQNNCNMFVASARQLAKALEVPLVNDLGYTKRYVRCLQISEVVNSMKDLIDYSRETRTGPIESLAKFPRRTGPSSALPGPSPQQASDQLRQQQQQQQQQQQQQQQQQQQQQQQQTVSQNTNSDQSSRQVALMQGNPSNGVNYAFNAASASTSTSSIAGLIHQNSMKGRHQNAAYNPPNSPYGGNSVQMQSPSSSGTMVPSSSQQQHNLPTFQSPTSSSNNNNPSQNGIPSVNHMGSTNSPAMQQAGEVDGNESSSVQKILNEILMNNQAHNNSSGGSMVGHGSFGNDGKGQANVNSSGVLLMNGQVNNNNNTNIGGAGGFGGGIGQSMAANGINNINGNNSLMNGRVGMMVRDPNGQQDLGNQLLGAVNGFNNFDWNA
The following text describes a protein:
Function:
Putative Notch ligand involved in the mediation of Notch signaling.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MSLTRSPAHRSAARALQLVLLSACFQVSPASGHFELRILSVQNKNGQLQNGACCDGSSSVLNGRCTGGQCDTYFRVCLKEYQLKVSPVGPCSFGTASTPVLGGNIFSFVNFKNSKARILLPFSFAWPRSYTLILEALDFNNDSLSGSVGGALIEKAIHSGMITPSPQWQKLEHNGPVAQFHFQVRLRCDEHYFGFGCNKFCRPRDDFFGHHMCDHNGNKTCLEGWSGPNCNAAICKQGCSTEHGFCKVPGECKCLYGWQGQHCDQCIPHPGCVNGSCVEPWQCLCDTNYGGQLCDKDLNTCGTRQPCLNGGTCSNTGPDKYHCSCPKGFSGVNCQIAEHACLSGPCLNGGSCTENSRGFECLCAPGWTGPLCSINVDECLENPCSHGGTCQDLVSGFRCICPPQWTGKTCLIDANECDDNPCVNAKSCRNLIGGYFCQCLPGWRGQSCSININDCHGQCQNGATCKDLVNGYKCECAPGFGGEHCERDLDDCASGPCLNGGSCHDRVNDFHCLCPPGFSGRRCQLDIDFCLDSPCLNGGQCFNSVDDYICECPEDYEGKNCSRLRDHCLTASCKVIDSCTVAVASNSTPSGVRLITSSVCRPHGQCQSHANGQFSCRCEEGFSGTYCHENINDCEIAPCLNGGTCIDEVSRYRCICPKGWEGPTCENNIDDCSSAPCQNRGVCQDLTNDFYCKCGDGWKGKTCSSRESQCDDVTCNNGGTCYDEGDAFKCLCPAGWEGSTCNIAKNSSCLPNPCENGGTCVVDGDSFRCICREGLEGPTCTQNANDCQPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGSTCVDEIDGYRCVCPAGRTGPLCQEAADRPCVHGGVKALHGSRWNEDCNSCRCLNGRVTCTKLWCGPKPCSLHSQNLAADCPAGQSCIAVRDEHCFVKPCVGQGQCWGHTHRATPPSGCHSESSCANVTFTFNKDIMAKGVTVEQVCHELRSLYAIKNLSSDSSVSVACEPSLRANNEIQVTIITDDQRRGLTLIKEVTDRVTDVVSKRSTNSTILQAITEVRIQRRPSQDPSGYLMPLLVSMVILVWALAVGSVLLWCLKRRKPGGHTGVITQAPSPSGPAAEDNNALHNSVSAAREQLNHIKNPIEKKPPNHHHHHHLLHHHLCEDKNSVNFKTCKFESSGSQSDEDEVEKKLQKRRFPLAPPAYSPRHVRSKPPHWTNKQDNRQLQSQSVNRAELVA
The following text describes a protein:
Function:
GTPase-activating protein.
Sequence:
MSYEYYYQQQQQQQQQQQQQQQQPTFDYASYYDNQQQQHPQPQYPVYDHTAQSNDSQQQHYGSSYVDPTYATTSTTQQQQQQPSIYDYNTGGNRNSGQYDQYNTTNTTTPNTTQNYDYSNTSGNRNSGQYDQYTTTNTTSANTYGYDNSKTHSPTPSSYDYSTNSYYSQQQQQQPTPTVAATNNTTNTSTNYDSYYQPPAQRNSYDYSQTQQQHSPTSSYDYSQVTNNTATNYDSYYQQPTTPTSTSSSSSTTTTTTTDNQSKFEKSQSLKNMDHFIKGTPSNTPSATINSWDYNQQQPQPQQPQSVYNNPSSSTTNTTYNNPSTTTTTSSPTNTNTTYNNPSSATNTNYNNRNSWGYDQSTYNNSSYNNNTDTYSNQTQQQEYQVLYDKKYQEEEEKRRKEYEESWRVYYEQQAAYEKEQERIRNEEMEKIRIKHEEESNRLKNELEKQRDEIQKMKDQLVQQQNASKKKGEEDLKQMEQAKQAALQWQQEEMKRQLIEVQKERDLSRKHEEQVRLALLEEQRVIKEKLDEKQQQLISQQQAFQSKLHQDECSRKVEEEKKCEEMKKREFELLERNKELDALKSKLQSDLTTSLKSKEDLENQRKALEETTLREKKEIQIYKQSIDEETKRKKLEIEQARQQEEKKLKEQQDHINRQKEMVDCQQRELLVQINQSKQATIDSLQPMRNMLSTLNINNKNSPASNIALKNKDDQNINDNLPQQKPVIPSRNSSHLPKLSPTIQQPQPQQEQPPQQQQQQQQQQQQQQQQQQPVKIVKTYTQKELDQIVDGNYRFGDIIRVQRVSRKWLARKKFKDLVKMKLLSNDPETENMRNRFKSVNELYSTELSYLNSLLILRDFYFIPMEVEARVTKLFKSEEINKVFSNLKSILQISTEITHLLEERLSVSPVKIGDIFVKFAPIFKIYVEYVNNFDKVAPQLKAMTENPQSKKFFSEQRNKSRVATDINSLLIMPVQRCPRYELLLREILKHTQEDHVEFKNIKSAYESIKDINKYINDRKRNVDNRAKLLELQKEIKNAPELIESHRYFVRESQCNISANKKSESGGFYLFFFNDMVLVTKKSSLFSNYKYVYTIPLKNADIKDISSNDSMIRIIVGSLESIDVLIYTISLPSKKDKESWLQDLSVELKPKGIEIGQYSSSQLLESQVQFSNSKTK
The following text describes a protein:
Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB12 may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy.
Subcellular Localization:
Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Lysosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane. Cytoplasmic vesicle, autophagosome.
Domain:
Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drives interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.
Sequence:
MDPSAALHRRPAGGSLGAVSPALSGGQARRRKQPPRPADFKLQVIIIGSRGVGKTSLMERFTDDTFCEACKSTVGVDFKIKTVELRGKKIRLQIWDTAGQERFNSITSAYYRSAKGIILVYDITKKETFDDLPKWMKMIDKYASEDAELLLVGNKLDCETDREISRQQGEKFAQQITGMRFCEASAKDNFNVDEIFLKLVDDILKKMPLDVLRNELSNSILSLQPEPEIPPELPPPRPHVRCC
The following text describes a protein:
Function:
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA (By similarity). The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product (By similarity). Likely functions in some aspects of cellular RNA processing (By similarity). Function plays an important role in a RNA repair and splicing pathway which controls axon regeneration in response to peripheral (PNS) and central nervous system (CNS) injury. In response to axotomy, negatively regulates splicing of Xbp1 which in turn activates downstream effectors which inhibit axon regeneration, including down-regulating the microtubule regulators ringer and futsch.
Subcellular Localization:
Nucleus, nucleoplasm. Nucleus.
Sequence:
MDAEKMLEIDGSYLEGGGQALRNALSLSCILGKPVRVVKIRASRPSPGLSHQHLHGLNLLRDITNADVVGNYLLSSTVEFTPRTILDNTYRVETHTAASITLIYQMALPVLLFAGRPSRLIVSGGTNVDFAPPVEYMQEVLLPNLKHFGVSFDLKVQRYGFYPRGQGRCQLDVQPVTKLNSGKLVAFGRIKSVSGVAYCAGRLPVNIAIDMQQTAQREIHRLWPSQQCSIEPIKHSRQKAFHNGAGILMTVNTTSDVVLGASALGKKRIDGHVLGSEASCQLGDYMRKQVCVDDYMQDQLIIYMALAVGRSTMRTGKLTNHTRTAINVAEQMTGVKFDVAMEPGGQMLVSCKGLGHVNKLI
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.
Subcellular Localization:
Mitochondrion.
Sequence:
MYFSCDDTAVAVVTSDRVILSSERITERAIQRKQGGINPSVCAQQHRQNLPILIEKCLEDAGTSPKDLDAVAVTVTPGLVIALKEGIAAAISFARKHKLPLIPVHHMRAHALSILLVDDSVQFPFSTLLLSGGHALIAVAENAENFKLYGQSVGGSPGECIDKVARHLGDLESEFDGVHAGVAVETLASRSSEFGHQRYPISFPSVGKADMNFDQIKGSYLNLLDKLRRTEKEKVNVSDFCASLQNTVTRHIASKLHVFFDTLDSEKRLPKQLVVGGGVAANEYIFNAVSKLSSAYGVSTVKTPLTLCTDNAEMIAYTGILMHLNRSESIYWRSEDIPDTIYAHARTPIGPDASSEILNFPRRELVNSTIHGSGPIRFRNYDNFRKVTLCRNS
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil.
Sequence:
MQCGWSGARVSSQLVPFTHSSLDALPPEFRRIPPYFYTFNCYAKGRWHGRTILDVFTNEFQAETPEYYRHAITEGLITVNSERVPLDFIIDNNHIILNKVHRHEPPVTNDPLSIVGETPDLLAIDKPASIPVHPCGRYRHNTVQAILGHEHDRWRVYPCHRLDRLTSGLLIFCKNPAMAKQFEQWITQHQVEKQYICRVQGRVEQSVLFCDAPLKICDQRLGLCCVHPEGKASLTRFRVIRRDKDTTVLHCFPKTGRMHQIRVHVQYLGHPIVNDPVYNSELWGPERGRGGALTRSSKIRILARVYRVSGTSVMSLVAGSIHPISPRLRMRMLSELVPAHAGLTPCERSWQIDRQDPAPEAMRIYLHAFRYRGPTFDFQTAMPWWSGEDWPQQLAKRQETY
The following text describes a protein:
Function:
Responsible for guiding the germ cells early in the process of migration from the lumen of the developing gut towards the overlying mesoderm, where the germ cells enter the gonads. May be involved in lipid metabolism.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPAVKIIMSTETSASETTPLRRSENETPDHKELAQSNSNSRQTTVNSNNNNYSNSVQVRLQEQDRDSDSEQQQHTATITMDTNKRILCRVGLDVLILLCAGFPILLFFLLGEPYKRGFFCDDESLKHPFHDSTVRNWMLYFIGAVIPVGVIFIVEVIISQNKAKQDNGNATSRRYVFMNYELPDWMIECYKKIGIYAFGAVLSQLTTDIAKYSIGRLRPHFIAVCQPQMADGSTCDDAINAGKYIQEFTCKGVGSSARMLKEMRLSFPSGHSSFTFFAMVYLALYLQARMTWRGSKLLRHLLQFLFIMVAWYTALSRVSDYKHHWSDVLAGSLIGSISALVVANYVSDLFQKPNTKPYLARTVQDMNASPAQAITITTN
The following text describes a protein:
Function:
May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.
Sequence:
MEDVAPVLAGPSQPTFSRPSERRNRKSGTANIFQGVNLRQLRRLFQVAGDPDAEQRARMVWGRRRAAGGAEDGADAEQDEDSGAAEVETGLAQALVGLRVRARNRSGLRVEQHKDTSGQRWVRAFGHLRINEGSLNPTTEGTPAEDEEVNEEEEESSAAGGQSSFESSSHDQGDFPSTEEETQGPGPRWSWNAVQEKDPERYLHRIRH
The following text describes a protein:
Function:
Involved in control of cell division. Regulates probably the availability of alpha-tubulin for dimerization of alpha-/beta-tubulin, which is required for proper microtubule biogenesis. Decreased expression of TFCB results in enlarged mesophyll cells and leaf epidermal cells with bulged nuclei, increased ploidy and increased numbers of spindles and phragmoplasts.
Subcellular Localization:
Cytoplasm. Note=Not associated with microtubular arrays.
Sequence:
MATSRLQLEGDDSVHLHITHANLKSFSADARFSPQMSVEAVKEKLWKKCGTSVNSMALELYDDSGSKVAVLSDDSRPLGFFSPFDGFRLHIIDLDPSSVTTGGWLEDTSLVEKYNISEEDYAKRTDSFRKFKEKRVSQNPVAAEAKTKENYMEDLCANIKVGDRCQVEPGEKRGMVKYVGRAESLGPGYWVGIQYDEPLGKHDGMVKGTRFFECPRLQGGMVRPDKVKVGDYPERDPFEEDEI
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MDSPASRLLPTETPNVGGNEFGDLDDLFDYDAGDTNDPFSENYVVPGSKDKEKGKESASNKKTGAGLGIDEEIEVTKKPRVPRVKLDEHKLLSSAGIPKLRKKAADHLKFKGKGHEYSDAARLLAFYQLWLDDLFPKAKFSDALAMVEKLGHKKMIQSARMDWINEGKPKYSEHEESLFDEPGLPPRSDNERGRTASRIAPIFENAVPTRPRTPVLNQDPDFDDMYDATPRILRQQPVAQSASVFGGGDNSLLGPQKVTATEEDAPPDDDLEALLAEAEQEGGNEEMLDDDLEALLAVENDMNAPARLAKHHTEKSAQADVDDMDAIEAMADMDFDMDMDGGW
The following text describes a protein:
Function:
Acts as a negative regulator of hedgehog signaling probably by promoting internalization and subsequent degradation of smoothened protein (SMO) present in the ciliary membrane. Plays a role in sonic hedgehog (SHH)-induced spinal neural progenitor cells differentiation.
Sequence:
ISGCLFLAANIFAIASITNPDWLNTRESVGALTVGLMGQRQTMHGRDGMCIPLQLPLEWVTTLFFIIMGIISLTVKFPLDRRREATKYVRWIAFTGMMLFCMAAIIFPIGFYINEVRGQPYKLPNNTVVGSSYVPFVLSISLQ
The following text describes a protein:
Function:
Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MKLKKQVTVCGAAIFCVAVFSLYLMLDRVQHDPARHQNGGNFPRSQISVLQNRIEQLEQLLEENHEIISHIKDSVLELTANVEGPPALLPYYVANGSWVVPPEPRPSFFSISPQDCQFALGGRGPKPELQMLTISEELPFDNVDGGVWKQGFDISYSPHDWDSEDLQVFVVPHSHNDPGWLKTFDKYYTEQTQHILNNMVSKLQEDPRRRFIWAEVSFFAKWWDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLEKNLGATPRSGWAVDPFGYSPTMPYLLRRANLTSMLIQRVHYAIKKHFAASHSLEFMWRQTWDSDASTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRISCPWKVPPRAITEANVAERAGLLLDQYRKKSRLFRSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFLNSKPDLHVQAQFGTLSDYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKNLDRVLEAHLRGAEILYSLAVAHARRAGLASQFPLSNFALLTDARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVSLKQVIMNAAHYLVLGDKKTYHFDPEVPFLQMDDTRLNHDALPERTVIQLESSPRYVVLFNPLEQERLSVVSLLVSVPVRLPALGLGVLQLQQGLDGPRTLPSSVRVYLHGRPLSVSRNEAFPLRVIDSGTSDFALSNRYMQVWFSGLTGLLKSVRRVDEEQEQRVDMEFLVYGTRSSKDKSGAYLFLPDGEAKPYVPRDPPVLRVTEGPFFSEVVACYEHVHQVVRLYNLPGVEGLSLDVSSLVDIRDYVNKELALRIRTDINSQGIFFTDLNGFQVQPRRYLKKLPLQANFYPMPVMAYLQDAQNRLTLHTAQALGVSSLHDGQLEVILDRRLMQDDNRGLGQGLKDNKRTCNHFRLLLERRTPGREVREAASASFPSLLSHLTSMYLNTPVLALPVARRQAPGPALRSFHPLASSLPCDFHLLNLRTLQAEEDGLPSAETALLLHRKGFDCGLEAKNLGFNCTTSQGKVALGSLFHGLDVVFLQPTSLTLLYPLASPSNSTDVYVEPMEITTFRLRLG
The following text describes a protein:
Function:
Required for vacuolar assembly. Acts as a component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion (By similarity).
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein.
Sequence:
MHRAFSLYRVLELSKARVECVFELGGLVYVSNSNGDLDSYKIYNNEEEEAADFVMEHVDVYPNFTKKPITKVVSCATQDIFYALSDSQVYVYQISTFKKLFSFGAHCQNMCLYGDELIVLSSKKNLEIYEIQKNSKPNLTKTISLNDRPRSLAWVSPTMILVSLSNDFCAVNTETSRISSLNLAWQQSSSLGLGISYIGMSIKSNKLHITRISDDEVLLSKDSQGLLVNLKSLQVSRNPLRWPTVPQAVIYNSPYIITLHNQYIYIWNKETYAMIQQIGISNIYSTFSCHKNTFFTSNSYVWILTPEDFSNQIEALLNTENLNEAISVLSQITVSQFPKRDYYLRITKREKALRSFSSGDYDLAMRLFSEISESPSTVLGLFPGLLDNNYSDAISILSMAPSQNESIESNVLFPGNHSNSQTDLRNGDAVSTVANNKRLRSLSTYLTDSRRKANRFLSYDEEHYFLQKKNLFLNADGTLVAKEKLEKIAVQIDTTLFLIYMISSPALVGSLLRLPNRCETSVVETNLLSAKMYRELVEYYYGKSLHEAALDLLTKLCDEPTDTLSLKGKSNTTSKYEPILSYLEKLSPELDHLIFKYSRVPLSEDPQNSIVIFIDENSEASTISKGVVLKYLETISYKVSIIYLEKLLLDNKFNDTVFPTRLALLYLKRILELEETTDFKNQEVFKQTIEKLEDYLTNSKQYDANVVLQEINSQDEFLSTVSIILYRRLSRHQDALDVYLKILNDWEGALSYCNSVYSIDGETEPYYMLLAEISKNYKSGSLNILDFITKYSSRLDLNRVFPLLPKNISMKSYHSLFSSQFRQLFEELSNKETQSKLYQKRLEDLNEELTKVRSEKVVITREKTCLFCHKRLGKSVISIFPDGSVVHYGCAKKYVSSNHLPYEAY
The following text describes a protein:
Function:
Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MPDATGVIARNPFEEAPSRLNQYTPEEAAALQARLEKKLGPEYISSRPGAAGLKVHYLAADKCINLANEVFGFNGWSSSIQNIQIDFVDESPNTGKVSLGLSVIVRVTLKDGAYHEDLGYGHIENCKGKAAAFEKAKKEATTDALKRALRNFGNVLGNCIYDKDYISKVSKLKTVPSKLDVGDLHRHPDFAPIKKEPMRVKPSLEDDDLPPNPSIAGRNTSTNSAADMDAEFGSDVFDEADFNVGEGEYPDGIVAEDTQKRHQPPTPVGRPNAHLNLPKHALGAQASGNQHVVTPSKPERPMNLAPAGRQIPNQALNNRPFPPPAQNQYTNQRQSVPLPGSNGGLQNGRSIPLGQRASNGMATGSDAGAQVPIKQEHGAKQPNPAPQNTAVPATPGINGQGPPVVGFLSARGADMLRENPHSAATVAPAFNPHAESPSIRKTAGVDHTKSIPISKPMLAGSASPLSNQTRDFINPSAEMHRKIGAPSGSVVGGPMNRGPSVSSYRPLTRPNVDPKAAAQNNTAAANRMAPNMNGKRPPLNDVTNETLPGGNGCTPAPGLNDPKRAKYDESMSAQQHQQQHQH
The following text describes a protein:
Function:
E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
Sequence:
MDSDFARHVHSSDIDWIESLFERFEKHEPMDSSWKYFFEGYQVGKTEGSPTESSHDQVFTSLQEKKAHSLLMIYRYYGYLQGQVSPISSSEESSLVTEKVRNFDPQEEIPSLGLLPQSYVRIADFIQVLKEKYCRSIAVETLNCSPEIQEYIWKLMEGEKPSLTKEVLLARYRDVKRAVAFEEFLQVKFTGQKRFSLEGGESLVPMLEHLIACGVKQGINRYVMGMPHRGRLNVLANIFGKPYRQIFMEFEDAPQIRGLETVGDVKYHKGYVANRPEQNVMMALLPNPSHLESVDPVVEGAVAAIQHQGEAGKEQACLAVLMHGDAALAGQGVVYETFQLSGIPGYSTEGTVHIVVNNQMGFTAQPRESRSTPYCTDIAKMMGIPVFRVNGEDILACLQVMEYAIHIRERFHCDVIIDLCCYRKYGHNESDDPFVTAPFLYEEIKKKKQGSELFKEILLHHPEWNISSDELERIDTEIAHVLNQEYASLKDPGVERLDKKECMHCTRMAAGELLVDNVDTSLDKEALFDLSAKLCDIPEHFSPHAKIRSLLNKRMSMADGEIGYDWGMAEEVAFASLLQEGFSLRLSGQDSIRGTFSQRQLVWTDVQTGDTFSPLYHLSPSQGSVELYNSPLSEYAVLGFEYGYAQQAEKTLVIWEAQFGDFSNGAQIIFDQYISSGIQKWDLHSDVVVLLPHGYEGQGPEHSSARIERYLQLASDWNFQVVLPSTPVQYFRILREHTKRDLSLPLIIFSPKMLLRHPQCVSSIAEFGMKGGFKPFLEDENPNYHAKVLVLCSGKIYYDYRASLPKDLEYRFACIRVESLYPLYLEDLLVLISKYTEVHHYVWLQEEPQNMGAFSYFALATDEIFPSKLQCVCRPRSSSTATGSASLSQKELSTLMETLFSIGRE