lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MDGVVFSIPTNRADLLNESERKYTVKNVVVSSEILKKLEEARTGLLEEGPYFILDNFDTYYSILHQENKLSIDVIQKGFNSLLKAVKQLNDTILFLVEDPASLSEESKSKMANVLKMLTYIFVQFVLYLEEKNKRSGDLLSKGKKEKKHDNFGVNKSEVVKALNNIIQRPINVFWQPPIVEHEYIELLSELCFGLLQNPSIKQEKVVIMDIFGVFGKLVKSYDFGETFVARMIRNVCMYEHVVHCVPEGIKMMVEQFSCQNLVHHLIIEATEWQATETVQDVQGTRCCSIFLTELAKTVPNLVFPEVTDLSLYLAHQSVPLRTAVLNVITEIILHVLTRHDLNQEEKDSRATCFDILTEHILEYSPIIRAKVIQNLNRLQKENAIPLVIQNDVLSKVVRHLSDKSATVRKCAVSCVTTFLECNPFGAKLQLSEAEEQLAQKIELLRKMEAAYQEQLVAKVQELEAGWLTIENDLLVVVTEELKTDEDEDEDERESVESEQFAEQIQSLLHEKKYAEAFRMCRRFTNNIPESRNVANEDQAKFYMNILRSFYINTVKFLTEMRTTAGMSQEDVEKIKALEGVIKYFEDMVKFLRTIHSVVEPMKMVLLSDTMSDTHEAIKFFVSAYHFKIDNANEGIIEMLKMMRTNHEERKSAVTEALRTIYLVTDTKSMEEHTTTILNRLFALLRNLTYDRLEDFQDVVSEWTAKGILDNAVINRCWQYYTQHEHVSAEDARAAAVLLRMAAMGRKTIITKNLNVVATMAFSQQYKSDMLFLANSFRLLSVAGLDKIDVQSEETPFRIKKTEDLFHQLSDNLIENFFNDLPYYSEAMQACTDFTFRMCSKPMEIIENIIKEIDERFRQRPQTIVLSIRFLEMLGCIALKFLEYLDNGVHREMKRRTYLRQEREKAKANKKNKRKSKRQSVLDTSNASDVSLSGSIVLGAEAEDVDTEYIIEALENDVVSKKGVLGQYAPFVLKFCQRPDIYSDVLLQTAAVTTLSRYMLISSKFCAENIRLLFTILAKTSHPDIRSTISMHCVDLLTRFPNIIDPWSPRLSEMLKDSVAEVRKNAFFSLSNLILRDMIRASSRISEMAVCLIDPDPEVSQLCRSFFTKIAQKDNNNIVSLIPDIFSYLVKQEEITEADLRYVIKFLFDLIDVPKRPENLVDRLCHKYTPDENVRLNRNITYCLSLINYNDKALQKLRDMFPLYRHNVTDEEVYSTFKQILNECGKAKVGRVDLKPIVTEIENCIASVFEIHEGGPPVKPPTVAKSGRTGRKKKGPAKRARKVQSDSEEEDSGEDALPKSTPSRNKTSRNRRNS
The following text describes a protein:
Function:
Regulatory protein of the TOL plasmid xyl operons. XylS activates the xylXYZLTEGFJQKIH operon required for the degradation of toluene, m-xylene and p-xylene.
Subcellular Localization:
Cytoplasm.
Sequence:
MPGVVFFVKDERARYVLVNRTLARRCGVKDKAELLGRSADEVFPSSLGPLYAEQDRRVLRGGATLENQLELHLYPGRQPGWCLTHKQALRDADGAIIGMAGISHDLPAAQSAHPAYGRLAAVDAHIREHYDQPLSLADLTAIAGLSVAQLERHCKRIFQLTPRQMIHKARLGAASQLLAGDAPITEIALRCGYTDHSAFSRQFKALTGLSPSQYRETHRQPRKA
The following text describes a protein:
Function:
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
Subcellular Localization:
Chromosome, telomere. Nucleus.
Sequence:
MAARTGRRRTEPVSGRRILRRLTSFLGEGRAAAKAEVMAGGSGDGRASGRRPSKSIGRSRRARQEPALRGEVGRGADEARLEEAVNRWVLKFYFHEALRAFRSGRYGDFRQIRDIMQALLVRPLGKEHTVSRLLRIMQCLSRIDEGENLDCSFDMEAELTPLESAIVVLETIKTEFPLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPSTQKLRNDLLNIIRERNWAHPVIQNFSYETFQQKMLRFLESHTDDAEPFLLTTAKKVLKSQSAAEGTVTEDKHLAPEPVEKPSKEPFRQLPESPATFGISALKGAFKTLSTFQDPDAAFTKLDQKDILIPEQTSPSAALKNKRQRRTESPSSEPTDSTELQHKNKRLTISRLVLEQDSQISSEPSESPDSSQESVVSSASKPMVLKLHNQPLSGEKSRKSHKGKWNSSNGVEEKDTWIEEDDLFQVQAGPDGEANNSAVGTKKQKWTVQESEWVRAGVMKYGEGNWVVISKNFPFVNRTSVMIKDRWRTMKKLGMN
The following text describes a protein:
Function:
Extracellular metalloprotease that contributes to pathogenicity.
Sequence:
MGISHLLGFTCVAVVLYQFGAHGKPHGGKVRYDNFRVIRMVPKSQEELECLNDFIASRHDLDVWKEPSKVGHHVDIMIPPRPADLEDVVIMATYAGIQRSIMIDDVQQLIENESLSQNLPSRSLTEFDKFDYTIYHTFEEIDAWIDDVADQYSNLVSVEAVSSTHEGKRVRGLKIGKPSENPKPIAYIQGGIHAREWVSPATVMFMTYKLLKAYGEDATVTEMFDKLDWYIVPVLNVDGYIYTWTNDRNWRKNRRMAPGNLCVGTDLNRNYDYKWGGQGASPLSCSIKYRGTGPASEIEVVGITDFLTKKNQTADIHLSLDFHSYGQLWLYPWGYTDDTTVLQPNRERQRALGLKAIEAITATHGKTYFVGEVGPYLYPASGGSVDWLYGELGIKYTYAIELRDEDKYGFFLPEKEIQPTTEEIYAAILVVGQQLISEL
The following text describes a protein:
Function:
Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKVITCEIAWHNKEPVYSLDFQHGTAGRIHRLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEAEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYIIQKKRVAFNVSKMLSGVGAEGEARSYRMFHDDSMKSFFRRLSFTPDGSLLLTPAGCVESGENVMNTTYVFSRKNLKRPIAHLPCPGKATLAVRCCPVYFELRPVVETGVELMSLPYRLVFAVASEDSVLLYDTQQSFPFGYVSNIHYHTLSDISWSSDGAFLAISSTDGYCSFVTFEKDELGIPLKEKPVLSMRTPDTAKKTKSQTHRGSSPGPRPVEGTPASRTQDPSSPGTTPPQARQAPAPTVIRDPPSITPAVKSPLPGPSEEKTLQPSSQNTKAHPSRRVTLNTLQAWSKTTPRRINLTPLKTDTPPSSVPTSVISTPSTEEIQSETPGDAQGSPPELKRPRLDENKGGTESLDP
The following text describes a protein:
Function:
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
Subcellular Localization:
Nucleus.
Sequence:
MGIKQLLPFVSSIIHKSSIDKFKNKKAAIDGYALLHRIATRNPRQIVLNNDYSFIVNGMLEYLKFFNTHKIIPIFVFDGATLPSKKGVEEERLNRRKSAYSNALKYEKEGKQIEALVCWKQAIDITPFHASKVINAFHKRGVQCIVAPYEADAQMAYLSRTGYVDVVICEDSDMIPYGCSVVLFKLNVVSNTCDVYQAQDLPKTPFGINITLFQLQITCILSGCDYFQGVNGIGLKKALKIVGSCKTIKQVILSLKKNYNKPLPNNLEEQLNDALFTFNHQYIYDIEEKTIIPLTDFEGNETTELIERTLGKKLDQGSVIQIAEGKIDPNTLEPFKNNEIDIFDLEPIPEIKQFQTSQKSPKWCVDDILKKVHPQNEENEDSNELVSGEEESKLDSQPISEIKIEEPQSTVQRKDDFHEETEIKSNIIDNDPFEPENSFTFIQEDLTSLKRVRYEENNDDELTELSTFSNKTPSDIEQPLSKRKFE
The following text describes a protein:
Function:
Structural component of the short non-contractile tail. The tail comprises six fibers made of gp17 trimers, 2 nm in diameter and 32 nm in length. May attach to host lipopolysaccharides (LPS) to mediate primary attachment to the host cell.
Subcellular Localization:
Virion.
Sequence:
MANVIKTVLTYQLDGSNRDFNIPFEYLARKFVVVTLIGVDRKVLTINTDYRFATRTTISLTKAWGPADGYTTIELRRVTSTTDRLVDFTDGSILRAYDLNVAQIQTMHVAEEARDLTTDTIGVNNDGHLDARGRRIVNLANAVDDRDAVPFGQLKTMNQNSWQARNEALQFRNEAETFRNQAEGFKNESSTNATNTKQWRDETKGFRDEAKRFKNTAGQYATSAGNSASAAHQSEVNAENSATASANSAHLAEQQADRAEREADKLENYNGLAGAIDKVDGTNVYWKGNIHANGRLYMTTNGFDCGQYQQFFGGVTNRYSVMEWGDENGWLMYVQRREWTTAIGGNIQLVVNGQIITQGGAMTGQLKLQNGHVLQLESASDKAHYILSKDGNRNNWYIGRGSDNNNDCTFHSYVHGTTLTLKQDYAVVNKHFHVGQAVVATDGNIQGTKWGGKWLDAYLRDSFVAKSKAWTQVWSGSAGGGVSVTVSQDLRFRNIWIKCANNSWNFFRTGPDGIYFIASDGGWLRFQIHSNGLGFKNIADSRSVPNAIMVENE
The following text describes a protein:
Function:
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MMKSVIIASLACSAAAFAPASNGRAATSLEASAKSKALPWLPNPSNLDGRIGANGFDPLGISEYFPVDYLVESEIKHGRVCMMAWAGYVAVDLGARIYPLPESMQGVTSATAHDPAVAFGSMGNMFIWIALFEMVGWIGLSQTLQGSGREPGDFGWGKQFMGKTQAEIDTMKLKELTNGRAAMLAFAGVVTQSVLYDKGFPYF
The following text describes a protein:
Function:
Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters (By similarity). May also potentiate the activation of RAF1.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
Interacts with RAF-1 via its C-terminal ankyrin repeat domain. The same domain also mediates its homodimerization. The third ankyrin repeat is required for association with the two other RFX subunits; RFX5 and RFXAP. The three central ANK repeats mediate binding to the PxLPxI/L motif of RFX5 (By similarity).
Sequence:
MEPTQVAENLVPNQQPPVPDLEDPEDTRDESPENSDTVVLSLFPCTPDAVNPEADASASSLQGSFLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELSQLKDHLRKGACPACTCLSGNNLINKPDERGFTPLIWASAFGEIETVRFLLDWGADPHILAKERESALSLASMGGYTDIVRLLLDRDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVMESHILRLFQSTLGPVDPE
The following text describes a protein:
Function:
Transcription regulator that acts as a central regulatory node for the integration of external bacterial signals leading to the regulation of secondary metabolite gene clusters such as orsellinic, lecanoric acid, cichorine, 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (dba), emericellamide or microperfuranone clusters.
Subcellular Localization:
Nucleus.
Sequence:
MTEPRRRWTAAEDALLWDLYQVQEKAPTGKCQKINWNEIARHIPGRTNKDCRKRYYNRFTGGLRKGSWTQEEDERLFRLVERYQYRWATIAQKMETRNADQCSKRWHHCLNPELERSPWTVDENMLLLSAVNTHGSSWKDIQKCHFPTRSANNIKNQYTILSRKNISLAPAHLHPCCDSPSPSKSSRRPPSTPTSTPQVPGSRQGSSYDPYDYGSLSSTPQLSATDYLPATPEAPAVNFDMAMGAFGDSCGYMPQYQPSPSFYANSPDGSELMMPETMGMRMRYDFRDGLEQEGVRYPGQETFGY
The following text describes a protein:
Function:
Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MSHGTYYECEPRGGQQPLEFSGGRAGPGELGDMCEHEASIDLSAYIESGEEQLLSDLFAVKPAPEARGLKGPGTPAFPHYLPPDPRPFAYPPHTFGPDRKALGPGIYSSPGSYDPRAVAVKEEPRGPEGSRAASRGSYNPLQYQVAHCGQTAMHLPPTLAAPGQPLRVLKAPLATAAPPCSPLLKAPSPAGPLHKGKKAVNKDSLEYRLRRERNNIAVRKSRDKAKRRILETQQKVLEYMAENERLRSRVEQLTQELDTLRNLFRQIPEAANLIKGVGGCS
The following text describes a protein:
Function:
Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events.
Subcellular Localization:
Nucleus.
Sequence:
MSMSHLYGRREEEEEGVEIESFEVTDWDLANEFNPERRRFRQTKEQATYGIWADKDSDEDERPSFGGKRSKDYSTPVNFVSAGLRKTAAEEKQQDKEEGSDDSEEDAPAVPPPTRGISQRFAGGIQSGQGIGTWEKHTKGIGQKLLQKMGYQPGKGLGKNAQGIVNPIEAKVRKGKGAVGAYGNERTQQSLQDFPVVDSEEEEEKEFQKELGQWRKDPAGSAVKKKPKYSYRTADELRAKGKMVSRNMAASAGELAQVKVIDMTVREPKVYYSYSQIANKHSVPDETPPAMSTRDQKGSGFALPELEHNLQLLIDLTEQDILQSARRLQHEKDVVVSLSHESRALQSRLEAEQDAIQKMEAVLALVERFPSGETPPGEGPTLQECAQIFETLQTDYYEEYKMMGLADLAVAVVHPLLKEKLHSWEPLKVCLKYSLLHVNVHILIFNCMCLSLLRLLWEVWIPVMRMCVSGWQPRMVGPMVDCVTLWAPLLPQWILDHLLEQLILPRLQREVDNWNPLTDTVPIHSWIHPWLPLLQSRLEPLYPPIRSKLANALQRWHPSDASARLILQPWKNVFTAGAWEAFMVKNIIPKLALCLEELVINPHQQQMEPFHWVMDWEGMLSPSSLVSLFDKNFFPKWLQVLCSWLSNSPNYEEITKWYLGWKGLFSDILLTQPLIKEKFNEALDIMNRAVSSGMGGYMQPGARENIAYLTQTERRKDFQYEALQERRDAESVAQRGIGSGVPTNFKDLIQAKAEENNIVFMPIVAKRHEGKQLYTFGRIVIYIDRGVVFVQGEKTWVPTSLQSLIDMAK
The following text describes a protein:
Function:
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.
Sequence:
MRGRAKNCIRVARERVEKALQHSYRDRKEKKREMRGLWIQRINAGTRQHGMKYSDFVHGLSTQNVQLNRKVLSELAMHEPYSFKSLVEVAKKPNEIRHHSQL
The following text describes a protein:
Function:
Functions in the intrinsic apoptotic signaling pathway and may have an interferon-induced antiviral activity.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MKRKFVGAAIGGALAVAGAPVALSAVGFTGAGIAAGSIAAKMMSAAAIANGGGIAAGGLVATLQSVGVLGLSTITNIILVAVGTATGARAEGSMGASREQESGPQDPPQELQEPQEPPSCKKQDLNLGKFVGAAIGGALAVAGAPIALSAVGFTGAGIAAGSIAAKMMSAAAIANGGGIAAGGLVATLQSVGILGLSTSTNIILGAVGAATGATAAGAMGACREQEPGLQDLQQEPKEPQEPQELQKQQEPQEPQELQKQQETQETQETQELQKTQEPPSYEK
The following text describes a protein:
Function:
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Subcellular Localization:
Nucleus.
Sequence:
MSDNESNPAGEVRGRSAMMAVADFPKMWDCLTTENVDFDRKEHLSHEEVAKELGVDPGIAKELADVCSIDTLHTSVTGVHSMTRHCHDNIMEGVLPEAGEQLQTLRSRVTTAAKYGRSGPPSQKSFSHYSYSKDTPGTITEPVVLLTVTMTVSNKVPIYSRMVKHDRELMVHANQPLSALKDKLLCPMDLVYLCGECSENPDTADDTRAQDLYKSSFIFIEDTFYSDMRDPKSRDITGKNYYLKTIMGCSYCFVSPVILFNPDRPLRQWIAQGKSVIISGEMKQAKMEETTFNDLSIRLGFPYLYVHQGDCEHNITFTDIRFMDENDCQDLEEFPLLCNQSAFYRNSCIGCKTLTAKWMTQEDSLSPTDPCFFCDVCYYKFHYDTKGNKLGNFKAYRHIDPSIFR
The following text describes a protein:
Function:
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MSAEAKANEYLAQGEKALKKTSFFSFGSSSQRNEDASDLFEKAGNQFKIAKNWQKAAEAFEKCARCQSRMNENSRAAQFYQHAAEALAKVNPMDAMVHYKTAISMLCDAGRFSNAAKLQKQIGEIYEQQDSKEEALEAYRQAADYFSGENQSSSANNMLLKVAQFSAELEKYDAALEIYESIAKSSMESNLLKFNAKNHLLNAGICALATKDMVLVQMKWDEFQDIDYTFADSREGKFLQAMNQSYEAFNADAFADAVFQFDNISKIEPWKITLLLRIKEGIIGEVDVAQDLT
The following text describes a protein:
Function:
Component of the DSC E3 ubiquitin ligase complexes that tag proteins present in Golgi, endosome and vacuole membranes and function in protein homeostasis under non-stress conditions and support a role in protein quality control. Involved in endocytic protein trafficking.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSAEPLLPTHNGSQGGEVRSPDQKFIVIRFSDVSVRDLQLNISNVPFSNINTHWLRRMCRELRPQQTQKRRLKFIRNGSILNTHSKIAEELTHYFDTANNSNVATGTSVAPEQNNYYIHCIIGTEELTQAELANEDLKDDATPSNDSMTTQAIGFDRLRSVGFTEQEIELLRQQFRATYGDLEEEEERLAQNGNRDDEGHDIRQLEEQWMESGSGTAQGNGAGGGNEDRFNSVPIANIKHNKDLLLGICVGFFFGVFGILLMKFDGLFNRRQKMAIFAGVIVNVMFCLVRGF
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MYVFDPTTEAGLRLEMAFPQHGFMFQQLHEDNSQDQLPSCPPHLFNGGGNYMMNRSMSLMNVQEDHNQTLDEENLSDDGAHTMLGEKKKRLQLEQVKALEKSFELGNKLEPERKIQLAKALGMQPRQIAIWFQNRRARWKTRQLERDYDSLKKQFESLKSDNASLLAYNKKLLAEVMALKNKECNEGNIVKREAEASWSNNGSTENSSDINLEMPRETITTHVNTIKDLFPSSIRSSAHDDDHHQNHEIVQEESLCNMFNGIDETTPAGYWAWSDPNHNHHHHQFN
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MIGAPTGCYKCGRTGHWSRDCTFDPKPGLPPPPPPPISSVPPPKSGRRRKRKLTPELLFSNEGLGYVLEHIPHRFPIKGRGHEGRDLHNLLRAYRHWHSNFFPSLSFKRFAREVAKVGRLRRVKKRLKECRTKFFKGVDDPKDCLKEDLPEPDIPSQEAPVQDNQNYTPIPISNPVSKDDPDYGQKMARMEANRLKALERARARIAAAAAAAAAATKTTQTNEQADNGIAS
The following text describes a protein:
Function:
Catalyzes the reversible hydration of carbon dioxide. Can hydrate cyanamide to urea.
Subcellular Localization:
Cytoplasm.
Sequence:
GPDTWWVYYPSASGGNQSPIDIQTEDVHTNHELTAHPLQINYQTSGAGNKDGGTSGGTAGSGSSSSITGGPLKEYNYVLSRIELHWGESDNNGSEHLVNSRPFSAEVQLIHWNEDLYDSYDEACKRDDGIAIIAVFAKLSDNEGNKTLQTWSKIIEDVEYRGKCMHVKEEFDVKALLPGLYFYDTAKYWCYRGSYTTPPCYETVTWVVMSQTINITSNILKQFRGLRSYYDTDVRPDDEYDGLIQKNCRPVQPLGTRKI
The following text describes a protein:
Function:
Acts as a negative regulator of autophagy.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLEIMAEHQDTLLKCKSEPLPPERRKRTVEDFNKFCSFVLAYAGYIPSTKEEPSWSPASSSSPNSSSGVSGEGVGVEGWPHAASDLHTIQTFVRKARASKGKSLRRLHSDSTLLDKMRLKDSLFEGQRSAGPKAERKKDKKLKKLSLGGREEKRARIKRSKNPKPTKGLKKLKSSSAHSETDSETGPAQEEGHSPAEEPTEPRKANQSGGEGLVEMLGGESTREAELSSSEGETWIADEDIMVESGDDSWHLITCYCGKPFAGRPMIECNQCGVWVHLSCAKIKKSNVPDIFYCHKCRDSRQDRRSGHKKDP
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSPSSRRSGGLLEGLYKVVMRRTSVYATFVIVGALVGERAVDYGVRKLWEKNNVGKRYEDISVLGQRTSE
The following text describes a protein:
Function:
Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin (By similarity). Involved in archaeosine (G(+)) and folate biosynthesis.
Sequence:
MSHQLPDVQASQPDVTVGLSQVGVTGVEKLVKIARDGKRPLVLMAEFEVFVDLPGGRKGIDMSRNMQVIDEVLEAAVSEPAYRVEDMCGDAAERLLAKHEYTTTAEVSMTAELVVREDTPASGLSTQSTAEIIASATATDEGTREEIGAEVVGMTVCPCSQGMSASRARDVLQDLAVDDDTIEEFLDKVPQPGHSQRGHATLTVETQGSPEVDLMDLIDIARDSMSARIYNLAKRPDEDHMTYHAHANAKFVEDCVRSMAELSLEALDHLGDDAVVHMKQSNDESIHQHNAHAEREVTLGQLRDELDA
The following text describes a protein:
Function:
Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B (By similarity).
Sequence:
MWSGQPQQDEGLPVGLSAIPVPWKNLGPSKSNRESSGGLVEASTSWEEAQGEEHPAPAPLDVSRLRSSSMEIREKGSEFLKEELYKAQKELKLKDEECERLCKVRAQLEQELEELTASLFEEAHKMVREANMKQATSEKQLKEAWGKIDMLQAEVTALKTLVITSTPASPNRELHPQLLSPTKAGPRKGHSRQKSTSSSLCPVVCPTAGHIPTPDKEGKEVDTTLFAEFQAWRASPTLDKSCPFLERVYREDVGPCLDFTVQELSALVRTAVEDNTLTIEPVASQTLPAVKVPTVECNNTNTCALSGLARTCHHRIRLGDSDSHYYISPSSRARITAVCNFFTYIRYIQQGLVRQDAEPMFWEIMRLRKGMSLAKLGFFPQEA
The following text describes a protein:
Function:
[Polymeric immunoglobulin receptor]: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment; [Secretory component]: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens. On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells.
Subcellular Localization:
[Polymeric immunoglobulin receptor]: Cell membrane; Single-pass type I membrane protein; [Secretory component]: Secreted.
Domain:
The Ig-like V-type 1/D1 domain contains three complementarity determining region-like loops CDR1-3, which mediate interaction with IgA and IgM.
Sequence:
MLLFVLTCLLAVFPAISTKSPIFGPEEVNSVEGNSVSITCYYPPTSVNRHTRKYWCRQGARGGCITLISSEGYVSSKYAGRANLTNFPENGTFVVNIAQLSQDDSGRYKCGLGINSRGLSFDVSLEVSQGPGLLNDTKVYTVDLGRTVTINCPFKTENAQKRKSLYKQIGLYPVLVIDSSGYVNPNYTGRIRLDIQGTGQLLFSVVINQLRLSDAGQYLCQAGDDSNSNKKNADLQVLKPEPELVYEDLRGSVTFHCALGPEVANVAKFLCRQSSGENCDVVVNTLGKRAPAFEGRILLNPQDKDGSFSVVITGLRKEDAGRYLCGAHSDGQLQEGSPIQAWQLFVNEESTIPRSPTVVKGVAGGSVAVLCPYNRKESKSIKYWCLWEGAQNGRCPLLVDSEGWVKAQYEGRLSLLEEPGNGTFTVILNQLTSRDAGFYWCLTNGDTLWRTTVEIKIIEGEPNLKVPGNVTAVLGETLKVPCHFPCKFSSYEKYWCKWNNTGCQALPSQDEGPSKAFVNCDENSRLVSLTLNLVTRADEGWYWCGVKQGHFYGETAAVYVAVEERKAAGSRDVSLAKADAAPDEKVLDSGFREIENKAIQDPRLFAEEKAVADTRDQADGSRASVDSGSSEEQGGSSRALVSTLVPLGLVLAVGAVAVGVARARHRKNVDRVSIRSYRTDISMSDFENSREFGANDNMGASSITQETSLGGKEEFVATTESTTETKEPKKAKRSSKEEAEMAYKDFLLQSSTVAAEAQDGPQEA
The following text describes a protein:
Function:
Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MISTCITVAGSDCSGGAGVQADLKVFTAHSVYGMSAVTAITSQNTIGVNGVHLIPASYVEQQISACLLDVHCEVMKTGMLFNQQILKVIVESIDRFKIKKVVVDPLIATRKGALLVMPDYLELFVKELIPRAEVLIPNIAEALIILKHMTNEFVEIHHLEDVKAVGKKLIKAGCKNVVIRCDDIPFASDFFCSRETNMPPTWYLYVLCTSEGEVLLPQKWLASKTARGTSCALSSAVASNLAIGLDLVTATQNAVSYTQRALEMSFHLGRGANSLDYASALTRLPYEKGEFINFVRYHPSITPKWLSIVNHPFVEQLKAGTLSRLPFQKYLVLKYHMLINNAQAAGMMAFSSSSISAIEHSAKIIQAIKEENVTHLRICEQYGLSASQITKSKPEIVKSHSLFIHDTAQQDGLRGIQIAMLPFVFMIQEVVSQISASDGYPYVAWVEHCKDKSATSHIETLLESLETNSQIISLSKVQHLLGILEKSLDFERLVLDTSSSNESSVF
The following text describes a protein:
Function:
This transcription activator controls cholera toxin, pilus colonization factor and outer membrane protein expression in V.cholerae. It binds to the 5'-TTTTGAT-3' tandemly repeated DNA sequence in the cholera toxin promoter region. ToxS interacts with the C-terminal periplasmic domain of ToxR, stimulating its activity. It activates transcription at the promoters for tcpI and tcpA and this is presumably via ToxT.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MFGLGHNSKEISMSHIGTKFILAEKFTFDPLSNTLIDKEDSEEIIRLGSNESRILWLLAQRPNEVISRNDLHDFVWREQGFEVDDSSLTQAISTLRKMLKDSTKSPQYVKTVPKRGYQLIARVETVEEEMARESEAAHDISQPESVNEYAESSSVPSSATVVNTPQPANVVTNKSAPNLGNRLLILIAVLLPLAVLLLTNPSQTSFKPLTVVDGVAVNMPNNHPDLSNWLPSIELCVKKYNEKHTGGLKPIEVIATGGQNNQLTLNYIHSPEVSGENITLRIVANPNDAIKVCE
The following text describes a protein:
Function:
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Probably carries the active site for 5'-splice site cleavage (By similarity).
Subcellular Localization:
Nucleus. Membrane; Single-pass membrane protein.
Sequence:
MDLPGPRWKKGKDGKDFASLAAANPMSAIVSELKASFISSKPVAILSGPGGSAVLGVGPEQAVILNRAAFGHAIENATAQKHWFQLSPEEVFYLCHALNCIRVDSLDNKQMSEIELWDYFRSGSESFPEMYKAYAHLRLKNWVVRSGLQYGADFVAYRHHPALVHSEFAVVVVPEGAEFGNRCGRLEVWSDLLCALRASGSVAKTLLVLTISSSSKCELSSPDCLEQLVVHERTITRWILQQCREQRCEPSRDEVNREELIIEKESVVFNHWGVILGFTVLSGLLVYRLKFRQ
The following text describes a protein:
Function:
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
Sequence:
MLSPQDRQDKLVRATDLDALSCKYSINRNLYLNPPDEFVKDLVESYQRYLQYCVGYTGLSSSRALKGLFQEKKMPIINRGSYLRTRAIDQVVNKFIGEFKDRCQIVSLGSGSDTRAFQIFKSHANVIYHEIDFPESAKVKKLAILQNPVIRELVGTNETSPLINNKEQFESYSSELHTEKYHLHGIDLRTLKKPDSQIKGFQPEVPTLVISECVLCYLSPDEYQRTMNYWTEIADQNYMGFLIYEPMSLNDQFGETMTLNLQSRGLNLQTFSKYPDLISRKKFLEESCHLKNLRLTDMSYIGGYKVRQDGREWIDHKEMGRINKLEMIDEIEEIRLLLEHYCLIYGEYTEEKTLNFKGIDTWSWILS
The following text describes a protein:
Function:
Snake venom endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. In venom, it is not toxic by itself, but increases the diffusion of other venom proteins by degrading the extracellular matrix. In addition, it displays antiedematogenic activity.
Sequence:
MIVNRVIWICLTFCFGATQHLQEHNWEQTTARPIVQHEPFVVVWNFPTVRCQERFGITLPLGAYGIVENKDNVFRGQNMTIFYKNQFGLYPYISEEGEWHNGGIPQNVPLKEHLERSSKEIAELLNHGFQGLAVVDWEEWRPLWRQNWGPKKVYREASEQWALGRFPDLSPQEQSYFAEVEFERAARALMETTLNTGKELRPQGFWGFYRFPECFNDNWEKEENYTGHCNPKEVQWNDQLMWLWKVSSALYPSIYLPPKLPPSYHQSYIHHRLREALRVAQFGPKQPLPVIAYSRVSYRHSSRYLAEADLLYTLGESAALGASGVVLWGDLSYSQSAESCRSLQHYITSTLGPYVINVTTAARLCSRQLCHGNGRCVRRHPSDLGAFLHLDPVISDGDIDFQHQEGLSWESFRCHCYPEWTDVWCQKPQWTEPIKGPEYNTNSQYYNIYDAAHDSNVIMKSNICPPPI
The following text describes a protein:
Function:
Probably binds to the DNA sequence 5'-TGAC-3'.
Subcellular Localization:
Nucleus.
Sequence:
ELKYQLLKKYSGYLSSLRQEFSKKKKKGKLPKEARQKLLHWWELHYKWPYPSETEKIALAEATGLDQKQINNWFINQRKRHWKPS
The following text describes a protein:
Function:
Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex.
Sequence:
MSGVLPEDNTLSSFTFDCLEIINTVEFSPFKRSSSLIAYGGDKRLAIAVCQFGEDTQEFQFEHVTDFHHGTRVQGIAWSPVTSVTHLPATVQLCSIGGDKQLRIFTTSGKADTSVSVMTGHTGYINACCYEPLRGEQIASVSDDYTCRLWDVETSATKACIPLSSPGMAVKWNPNEPNKLMVAEKKGIIRFYDLVSQQPIMSISTTQAPLMDADWALTDALRVGAVALMTGIYGTCLNQVSCALRVGGGLSWHSHLAICAAGGDKKVHIWAVEV